Possesses an unusual and selective cytotoxicity for VASCULAR SMOOTH MUSCLE cells in dogs and rats. Useful for experiments dealing with arterial injury, myocardial fibrosis or cardiac decompensation.
A group of compounds derived from ammonia by substituting organic radicals for the hydrogens. (From Grant & Hackh's Chemical Dictionary, 5th ed)
Naphthalene derivatives containing the -CH2CCO2H radical at the 1-position, the 2-position, or both. Compounds are used as plant growth regulators to delay sprouting, exert weed control, thin fruit, etc.
The second enzyme in the committed pathway for CHOLESTEROL biosynthesis, this enzyme catalyzes the first oxygenation step in the biosynthesis of STEROLS and is thought to be a rate limiting enzyme in this pathway. Specifically, this enzyme catalyzes the conversion of SQUALENE to (S)-squalene-2,3-epoxide.
Broad spectrum antifungal agent used for long periods at high doses, especially in immunosuppressed patients.
INDOLES which have two keto groups forming QUINONES like structures of the indole aromatic ring.
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
A nitrosourea compound with alkylating, carcinogenic, and mutagenic properties.
The milkweed plant family of the order Gentianales, subclass Asteridae, class Magnoliopsida. It includes many tropical herbs and shrubby climbers; most with milky juice. Flowers have five united petals. Fruits are podlike, usually with tufted seeds.
A subspecialty of internal medicine concerned with morphology, physiology, and pathology of the blood and blood-forming tissues.
Two-ring crystalline hydrocarbons isolated from coal tar. They are used as intermediates in chemical synthesis, as insect repellents, fungicides, lubricants, preservatives, and, formerly, as topical antiseptics.
Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.
A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.
The nonstriated involuntary muscle tissue of blood vessels.
Non-striated, elongated, spindle-shaped cells found lining the digestive tract, uterus, and blood vessels. They are derived from specialized myoblasts (MYOBLASTS, SMOOTH MUSCLE).
A plant genus of the family LILIACEAE. Members contain tuliposides and tulipalins and have been associated with allergic contact dermatitis in florists.
The branch of medicine concerned with the evaluation and initial treatment of urgent and emergent medical problems, such as those caused by accidents, trauma, sudden illness, poisoning, or disasters. Emergency medical care can be provided at the hospital or at sites outside the medical facility.
Five membered rings containing a NITROGEN atom.
Hydrocarbons with more than one double bond. They are a reduced form of POLYYNES.
Substances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues.
A genus of yeast-like mitosporic Saccharomycetales fungi characterized by producing yeast cells, mycelia, pseudomycelia, and blastophores. It is commonly part of the normal flora of the skin, mouth, intestinal tract, and vagina, but can cause a variety of infections, including CANDIDIASIS; ONYCHOMYCOSIS; vulvovaginal candidiasis (CANDIDIASIS, VULVOVAGINAL), and thrush (see CANDIDIASIS, ORAL). (From Dorland, 28th ed)
Infection with a fungus of the genus CANDIDA. It is usually a superficial infection of the moist areas of the body and is generally caused by CANDIDA ALBICANS. (Dorland, 27th ed)
Fungal infection of keratinized tissues such as hair, skin and nails. The main causative fungi include MICROSPORUM; TRICHOPHYTON; and EPIDERMOPHYTON.
Pyridine derivatives with one or more keto groups on the ring.
A genus comprised of spinner, spotted, and striped DOLPHINS, in the family Delphinidae. Schools of Stenella, that may number in the thousands, often associate with schools of TUNA, and are thus vulnerable to accidental harvesting.
Dermatological pruritic lesion in the feet, caused by Trichophyton rubrum, T. mentagrophytes, or Epidermophyton floccosum.
A mitosporic Loculoascomycetes fungal genus including some economically important plant parasites. Teleomorphs include Mycosphaerella and Venturia.
A normally saprophytic mitosporic Chaetothyriales fungal genus. Infections in humans include PHAEOHYPHOMYCOSIS; and PERITONITIS.. Exophiala jeanselmei (previously Phialophora jeanselmei) is an etiological agent of MYCETOMA.
Compounds possessing both a hydroxyl (-OH) and an amino group (-NH2).
The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
Synthetic organic reactions that use reactions between unsaturated molecules to form cyclical products.
Azoles with an OXYGEN and a NITROGEN next to each other at the 1,2 positions, in contrast to OXAZOLES that have nitrogens at the 1,3 positions.
Changing an open-chain hydrocarbon to a closed ring. (McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
Hydrocarbons with at least one triple bond in the linear portion, of the general formula Cn-H2n-2.
Works about lists of drugs or collections of recipes, formulas, and prescriptions for the compounding of medicinal preparations. Formularies differ from PHARMACOPOEIAS in that they are less complete, lacking full descriptions of the drugs, their formulations, analytic composition, chemical properties, etc. In hospitals, formularies list all drugs commonly stocked in the hospital pharmacy.
Economic aspects of the fields of pharmacy and pharmacology as they apply to the development and study of medical economics in rational drug therapy and the impact of pharmaceuticals on the cost of medical care. Pharmaceutical economics also includes the economic considerations of the pharmaceutical care delivery system and in drug prescribing, particularly of cost-benefit values. (From J Res Pharm Econ 1989;1(1); PharmacoEcon 1992;1(1))
That segment of commercial enterprise devoted to the design, development, and manufacture of chemical products for use in the diagnosis and treatment of disease, disability, or other dysfunction, or to improve function.
Organizations representing specialized fields which are accepted as authoritative; may be non-governmental, university or an independent research organization, e.g., National Academy of Sciences, Brookings Institution, etc.
Regulations to assure protection of property and equipment.
Laws and regulations concerned with industrial processing and marketing of foods.
Strongly cationic polymer that binds to certain proteins; used as a marker in immunology, to precipitate and purify enzymes and lipids. Synonyms: aziridine polymer; Epamine; Epomine; ethylenimine polymer; Montrek; PEI; Polymin(e).
Compounds based on a seven-membered ring fused to a five-membered ring. Heat can rearrange them to NAPHTHALENES which have two fused six-membered rings. They are similar to guaiazulenes which are SESQUITERPENES with a six-membered ring fused to a five-membered ring.
The study of CHEMICAL PHENOMENA and processes in terms of the underlying PHYSICAL PHENOMENA and processes.
The introduction of functional (usually cloned) GENES into cells. A variety of techniques and naturally occurring processes are used for the gene transfer such as cell hybridization, LIPOSOMES or microcell-mediated gene transfer, ELECTROPORATION, chromosome-mediated gene transfer, TRANSFECTION, and GENETIC TRANSDUCTION. Gene transfer may result in genetically transformed cells and individual organisms.
Derivatives of ammonium compounds, NH4+ Y-, in which all four of the hydrogens bonded to nitrogen have been replaced with hydrocarbyl groups. These are distinguished from IMINES which are RN=CR2.
Enzymes that catalyze the transfer of multiple ADP-RIBOSE groups from nicotinamide-adenine dinucleotide (NAD) onto protein targets, thus building up a linear or branched homopolymer of repeating ADP-ribose units i.e., POLY ADENOSINE DIPHOSPHATE RIBOSE.

Systematic review of topical treatments for fungal infections of the skin and nails of the feet. (1/66)

OBJECTIVE: To identify and synthesise the evidence for efficacy and cost effectiveness of topical treatments for superficial fungal infections of the skin and nails of the feet. DESIGN: Systematic review. INTERVENTIONS: Topical treatments for superficial fungal infections. MAIN OUTCOME MEASURES: Cure confirmed by culture and microscopy for skin and by culture for nails in patients with clinically diagnosed fungal infections. RESULTS: Of 126 trials identified in 121 papers, 72 (57.1%) met the inclusion criteria. Placebo controlled trials yielded pooled relative risks of failure to cure skin infections: allylamines (0.30, 95% confidence interval 0.24 to 0.38); azoles (0.54, 0.42 to 0.68); undecenoic acid (0.28, 0. 11 to 0.74); and tolnaftate (0.46, 0.17 to 1.22). Although meta-analysis of 11 trials comparing allylamines and azoles showed a relative risk of failure to cure of 0.88 (0.78 to 0.99) in favour of allylamines, there was evidence of language bias. Seven reports in English favoured allylamines (0.79, 0.69 to 0.91), but four reports in foreign languages showed no difference between the two drugs (1. 01, 0.90 to 1.13). Neither trial of nail infections showed significant differences between alternative topical treatments. CONCLUSIONS: Allylamines, azoles, and undecenoic acid were efficacious in placebo controlled trials. There are sufficient comparative trials to judge relative efficacy only between allylamines and azoles. Allylamines cure slightly more infections than azoles but are much more expensive than azoles. The most cost effective strategy is first to treat with azoles or undecenoic acid and to use allylamines only if that fails.  (+info)

Opposite effects of GABA(A) and GABA(C) receptor antagonists on the b-wave of ERG recorded from the isolated rat retina. (2/66)

The largest component in the fully dark-adapted ERG is a corneal-positive response, known as the b-wave, and believed to originate from depolarizing (ON-type) bipolar cells. The two types of GABA receptors, GABA(A) and GABA(C) have been reported to exist on bipolar cells in rat retina. The goal of these experiments was to find whether these GABA receptors participate in the generation of the b-wave of electroretinogram (ERG). ERGs were recorded from the isolated rat retinas. The P(2)(t) component, obtained by subtracting the ERGs measured before the application of 50 micrograms APB from those measured after the application of 50 micrograms APB, was used as an indicator of depolarizing bipolar cell activity. Photovoltages, the fast P(3)(t) component of ERG, were registered between the two microelectrodes across the rod outer segments. Bicuculline and 3-aminopropylphosphonic acid (3-APA) were used as selective antagonists of GABA(A) and GABA(C) receptors, respectively. It was found that the GABA(A) and GABA(C) receptors antagonists have opposite effects on the b-wave: bicuculline increased the b-wave amplitude, while 3-APA reduced the amplitude of the b-wave. Neither bicuculline nor 3-APA affect photoreceptors.  (+info)

New therapies on the horizon. (3/66)

Statins have proved to be potent drugs for reducing low-density lipoprotein cholesterol (LDL-C) levels. However, because the response to current statin therapy regimens is not always sufficient to reach defined goal levels, additional drugs to lower LDL-C are needed. New drugs may soon be available to lower LDL-C levels by mechanisms that differ from those of the statins. Among these new agents are a bile acid binding resin, inhibitors of bile acid transport, inhibitors of cholesterol transport, inhibitors of cholesterol esterification, and triglyceride-lowering agents.  (+info)

The development of an in-vitro perfusion system for studies on cultured cells. (4/66)

The design and use of a perfusion system, using a modified flow chamber for studies on cultured animal cells, is described. Rat thoracic aorta smooth muscle cells were isolated by an explant method and grown on Thermanox coverslips. These were introduced into the flow chamber. A flow rate of 25ml/min and a shear stress of 14.6 dynes/cm2 (12 dyne = 10 microN) (both within physiological limits) were maintained. Cells remained attached to the coverslips after 8h of perfusion with culture medium. The effect of exposing rat smooth muscle cells to the cardiovascular toxin, allylamine, is also described. The components of the system are routinely available, simple to clean, easy to assemble and sterilize. The incorporation of an in-line sensor that monitors pH, PO2, PCO2 and temperature ensures that the perfusion conditions remain within physiological limits. Automation means that minimal supervision is required. This system provides a potential mechanism in which cultured vascular cells may be perfused under controlled haemodynamic conditions, and their response to a cytotoxin may be evaluated.  (+info)

Overview of pharmacologic therapy for the treatment of dyslipidemia. (5/66)

Although the National Cholesterol Education Program Adult Treatment Panel III (ATP III) guidelines stress the importance of nonpharmacologic lipid modification interventions such as diet and exercise, the guidelines also recognize that many patients will require drug therapy to achieve low-density lipoprotein cholesterol (LDL-C) target goals. Currently available lipid-modifying drugs include bile acid sequestrants (or resins), fibrates, nicotinic acid, and statins, with each class exerting different effects on the lipid profile. In addition, nonprescription agents such as plant stanols and sterols have been shown to be effective in modifying plasma lipids. Of these agents, the statins are the most effective, most widely prescribed, and best-tolerated form of lipid-lowering drug therapy. New formulations of other drugs, such as niacin and bile acid sequestrants, can also improve treatment regimes and reduce side effects, thereby improving patient compliance with these therapies. In patients who have high levels of LDL-C and triglycerides together with low concentrations of high-density lipoprotein cholesterol (HDL-C), combination therapy may be required. Ezetimibe, a selective cholesterol absorption inhibitor, is the first of a new class of lipid-lowering agents and provides a new agent for the management of patients with dyslipidemia. Data from the ezetimibe clinical development program suggests that this agent can be used alone or in combination with statins to reduce LDL-C, improve compliance, and bring more patients to ATP III target goal.  (+info)

Regulation of alpha7-integrin expression in vascular smooth muscle by injury-induced atherosclerosis. (6/66)

Injury of vascular smooth muscle cells (VSMCs) by allylamine (AAM) leads to phenotypic changes associated with atherogenic progression including increased proliferation, migration, and alterations in cell adhesion. In the present study, the relationship between AAM-induced vascular injury and expression of the alpha(7)-integrin subunit was investigated. The alpha(7)-mRNA and protein expression were examined using real-time RT-PCR, fluorescence-activated cell sorting analysis (FACS), immunohistochemistry, and immunoblotting. In cultured VSMCs from aortas of AAM-treated rats (70 mg/kg for 20 days), alpha(7)-mRNA levels were increased more than twofold compared with control cells. No change was seen in beta(1)-integrin expression. FACS analysis revealed increased cell surface expression of alpha(7)-protein (25 +/- 9%; *P < 0.05). AAM treatment of naive VSMCs enhanced alpha(7)-mRNA expression (2.4 +/- 0.7-fold, mean +/- SE; *P < 0.05). The increased alpha(7)-mRNA expression was attenuated by the amine oxidase inhibitor semicarbazide and the antioxidant pyrrolidine dithiocarbamate, which confirms a role for oxidative stress in modulating alpha(7)-expression. In vivo alpha(7)-mRNA and protein expression were enhanced in the aortas of AAM-treated rats. In addition, increased alpha(7)-integrin expression facilitated AAM VSMC adhesion to laminin more efficiently compared with control (51 +/- 2%; *P < 0.05). Chemical injury induced by AAM significantly enhances alpha(7)-integrin expression in VSMCs. These findings implicate for the first time the expression of alpha(7)-integrin during the response of VSMCs to vascular injury.  (+info)

Ketogenic diet decreases circulating concentrations of neuroactive steroids of female rats. (7/66)

Ketogenic diet (KD) is used to manage intractable epilepsy; however, the mechanisms underlying its therapeutic effects are not known. Steroid hormones, such as progesterone and testosterone, are derived from cholesterol, and are readily 5alpha-reduced to dihydroprogesterone and dihydrotestosterone, which are subsequently converted to 5alpha-pregnan-3alpha-ol-20-one (3alpha,5alpha-THP) and 3alpha-androstanediol, neuroactive steroids that can influence seizures. The present study examined the effects of the KD on circulating concentrations of these neuroactive steroids, and their precursors, in intact female rats. Thirty-six, 22-day-old female Sprague-Dawley rats (weaned at 21 days) were fasted for 8 hours prior to placement on one of three dietary regimens for 6 weeks: ad libitum chow, calorie-restricted chow, or KD. After 6 weeks of the diet, when six rats in each dietary condition were in diestrus and six were in behavioral estrus, all rats were administered pentylenetetrazole (PTZ, 70 mg/kg, i.p.). The latency and incidence of seizures were recorded by an observer who was uninformed of the estrous cycle and dietary treatment conditions of the rats. Immediately after each test, trunk blood was obtained for later measurement of pregnane (progesterone, dihydroprogesterone, 3alpha,5alpha-THP) and androstane (testosterone, dihydrotestosterone, 3alpha-androstanediol) neuroactive steroid concentrations in plasma by radioimmunoassay. KD tended to lengthen the latency to, and significantly reduced the number of, PTZ-induced barrel roll seizures. KD also significantly reduced plasma levels of the pregnane (dihydroprogesterone, 3alpha,5alpha-THP) and androstane (dihydrotestosterone, 3alpha-androstanediol) 5alpha-reduced metabolites. These data suggest that levels of pregnane and androstane neuroactive steroids, or their precursors, may underlie some of the antiseizure effects of KD.  (+info)

Asymmetric synthesis of 4,5,6- and 3,4,5,6-substituted azepanes by a highly diastereoselective and enantioselective lithiation-conjugate addition sequence. (8/66)

Asymmetric syntheses of 4,5,6- and 3,4,5,6-substituted azepanes have been achieved by highly diastereoselective and enantioselective (-)-sparteine-mediated asymmetric lithiation-conjugate additions of N-Boc-N-(p-methoxyphenyl)-2,3-substituted allylamines to a beta-aryl alpha,beta-unsaturated ester followed by hydrolysis, cyclization, and reduction. Access to the enantiomeric adduct is provided by an invertive lithiation-stannylation-lithiation sequence.  (+info)

The bile acid sequestrants are a group of resins used to bind certain components of bile in the gastrointestinal tract. They disrupt the enterohepatic circulation of bile acids by combining with bile constituents and preventing their reabsorption from the gut. In general, they are classified as hypolipidemic agents, although they may be used for purposes other than lowering cholesterol. They are used in the treatment of chronic diarrhea due to bile acid malabsorption. Bile acid sequestrants are polymeric compounds that serve as ion-exchange resins. Bile acid sequestrants exchange anions such as chloride ions for bile acids. By doing so, they bind bile acids and sequester them from the enterohepatic circulation. The liver then produces more bile acids to replace those that have been lost. Because the body uses cholesterol to make bile acids, this reduces the amount of LDL cholesterol circulating in the blood. Bile acid sequestrants are large polymeric structures, and they are not significantly ...
Long-term (52â 78 weeks) treatment with colesevelam HCl added to metformin therapy in type 2 diabetes mellitus patients Harold E BaysLouisville Metabolic and Atherosclerosis Research Center, Louisville, Kentucky, USAObjective: To evaluate the long-term safety, tolerability, and efficacy of colesevelam HCl (colesevelam) in type 2 diabetes mellitus patients receiving metformin monotherapy or metformin combination therapy.Methods: This post-hoc subgroup analysis examined data from type 2 diabetes mellitus patients aged 18 to 75 years with a hemoglobin A1c of 7.5% to 9.5%, who received metformin as part of their treatment via their participation in one of three randomized, double-blind base studies wherein colesevelam (3.75 g/day) or a placebo was added to existing metformin-, insulin-, or sulfonylurea-based treatment. After completing the base studies, the subjects who initially received blinded colesevelam (n = 196) or the placebo (n = 166) entered a 52-week extension study wherein they received open
TY - JOUR. T1 - Allylamine and β-aminopropionitrile induced aortic medial necrosis. T2 - Mechanisms of synergism. AU - Kumar, D.. AU - Trent, M. B.. AU - Boor, P. J.. PY - 1998/2/6. Y1 - 1998/2/6. N2 - We have developed a model of aortic smooth muscle necrosis in adult Sprague Dawley rats by feeding them two vascular toxins (allylamine HCl, or AA, and β-aminopropionitrile, or βAPN) in concert for 10 days. Either toxin given alone does not cause aortic lesions. In order to shed light on the mechanism of the synergistic action of these two toxins we fed known modulators of AA or βAPN toxicity to rats concurrently with the two toxins. As modulators we used (a) semicarbazide (98 mg/kg/day, given 4 h prior to toxins), a known inhibitor of the vascular enzyme SSAO which metabolizes AA (b) L-cysteine (1.5% in rat chow, beginning 3 days prior to toxins), which has been shown to reduce the toxic effects of βAPN; and (c) phenelzine sulphate (3 mg/kg/day, given 4 h prior to toxins), an inhibitor of ...
0086]In one embodiment, the odor adsorbing fibers of the fabric may comprise a modified polyamine which comprises a hybrid inorganic/organic material comprising a polyamine and an inorganic oxide. The polyamine may comprise one or more of the following: amine-containing polysaccharides, amine-containing polypeptides, polyethylenimine, polyethylenimine derivatives, poly(vinylamine), poly(diallylamine), poly(allylamine), copolymers of diallylamine and allylamine, copolymers containing diallylamine or allylamine, copolymers containing diallylamine and allylamine, and condensation polymers formed from polyamine monomers and monomers with two or more amine-reactive groups, poly(lysine), polyethylenimine, polyethylenimine derivatives, poly(vinylamine), polymers containing diallylamine, and polymers containing allylamine, amine-containing polysaccharides, amine-containing polypeptides, polyethylenimine, polyethylenimine derivatives, poly(vinylamine), poly(diallylamine), poly(allylamine), copolymers of ...
The systemic toxic potential of Allylamine was assessed when administered to Sprague Dawley rats by snout-only inhalation administration for 4 weeks. Recovery from any effects was evaluated during a 2 week recovery period. Three groups, each comprising 5 male and 5 female Sprague Dawley rats, received Allylamine at target exposures of 5, 10 or 20 ppm. A similarly constituted control group received air only, at the same operating conditions as the high dose group. A further five male and five female rats were assigned to each of the control and high dose groups. These animals were treated for 4 weeks, followed by a 2 week period without treatment to assess the potential for any treatment-related change to recover. During the study, clinical condition, detailed physical and arena observations, sensory reactivity, grip strength, motor activity, bodyweight, food consumption, haematology (peripheral blood), haematology (bone marrow), blood chemistry, organ weights, macropathology and histopathology ...
Bile acids promote bile formation and facilitate dietary lipid absorption. Animal and human studies showing disturbed bile acid metabolism in diabetes mellitus suggest a link between bile acids and glucose control. Bile acids are activating ligands of the farnesoid X receptor (FXR), a nuclear receptor with an established role in bile acid and lipid metabolism. Evidence suggests a role for FXR also in maintenance of glucose homeostasis. Animal and human studies employing bile acid sequestrants (bile acid binding agents), which interrupt the enterohepatic circulation of bile acids and effectively reduce plasma cholesterol, support a link between bile acid and glucose metabolism. In lipid-lowering trials, bile acid sequestrants, such as colesevelam hydrochloride, colestyramine (cholestyramine) and colestilan (colestimide), have also been shown to lower plasma glucose and glycosylated haemoglobin levels, suggesting the utility of these agents as a potential therapy for type 2 diabetes. In this ...
Learn more about Bile Acid Sequestrant Drugs at Grand Strand Medical Center Many Nutrients - Supplementation Likely Helpful The bile acid sequestrant...
Page contains details about polypyrrole coated iron oxide nanoparticles modified with poly(allylamine hydrochloride) . It has composition images, properties, Characterization methods, synthesis, applications and reference articles : nano.nature.com
Page contains details about kinesin-NH2-NTA-modified sodium alginate/fluorescein isothiocyanate-modified poly(allylamine hydrochloride)/dextran sulfate sodium multilayer tubes . It has composition images, properties, Characterization methods, synthesis, applications and reference articles : nano.nature.com
Abstract : Non-viral gene carriers for safe and efficient gene transfection have become of particular interest among researchers of different disciplines ranging from physical chemistry to biotechnology. Recently polymeric vectors have been extensively studied as potentially new gene transfer agents. Until now most of the research efforts were made to optimize the gene-to-polymer weight ratio of polyplexes for safe and efficient gene transfection. In this work, we report on the development of novel poly(allylamine) derivatives with different balance of the primary, secondary, tertiary, and quaternary amino groups. All derivatives were able to complex pDNA into polyplexes at low gene-to-polymer weight ratios i.e., 1:1 or 1:2. Moreover, the examined polyplexes were less cytotoxic and showed better transfection efficiency when compared to linear poly(ethyleneimine). These results indicate that the presence of quaternary ammonium groups is important in the formation of stable polyplexes. Polymers ...
Learn about Welchol (Colesevelam Hcl) may treat, uses, dosage, side effects, drug interactions, warnings, patient labeling, reviews, and related medications.
Professional guide for Colesevelam Hydrochloride. Includes: pharmacology, pharmacokinetics, contraindications, interactions, adverse reactions and more.
Bile Acid SequestrantsPatients with terminal ileal disease may not absorb bile acids normally, which can lead to secretory diarrhea in the colon. These patients may benefit from bile acid sequestrants... more
Davidson DJ, Wilkinson MJ, Davidson MH. Combination therapy for dyslipidemia. In: Ballantyne CM, ed. Clinical Lipidology: A Companion to Braunwalds Heart Disease. 2nd ed. Philadelphia, PA: Elsevier Saunders; 2015:chap 27.. Genest J, Libby P. Lipoprotein disorders and cardiovascular disease. In: Zipes DP, Libby P, Bonow RO, Mann DL, Tomaselli GF, Braunwald E, eds. Braunwalds Heart Disease: A Textbook of Cardiovascular Medicine. 11th ed. Philadelphia, PA: Elsevier; 2019:chap 48.. Goldberg AC. Bile acid sequestrants. In: Ballantyne CM, ed. Clinical Lipidology: A Companion to Braunwalds Heart Disease. 2nd ed. Philadelphia, PA: Elsevier Saunders; 2015:chap 22.. Grundy SM, Stone NJ, Bailey AL, et al. 2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ ADA/AGS/APhA/ASPC/NLA/PCNA guideline on the management of blood cholesterol: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. J Am Coll Cardiol. 2019;73(24):e285-e350. PMID: 30423393 ...
A bulk polymerization method was used to easily and efficiently prepare homo-veratric acid (3,4-dimethoxyphenylacetic acid)-imprinted polymers from eight basic monomers: 2-vinylpyridine, 4-vinylpyridine, 1-vinylimidazole, N-allylaniline, N-allylpiperazine, allylurea, allylthiourea, and allylamine, in the presence of homoveratric acid as a template in N,N-dimethylformamide as a porogen. The imprinted polymer prepared from allylamine had the highest affinity to the template, showing an imprinting factor of 3.43, and allylamine polymers MIP8/NIP8 were selected for further studies. Their binding properties were analyzed using the Scatchard method. The results showed that the imprinted polymers have two classes of heterogeneous binding sites characterized by two pairs of Kd, Bmax values: Kd(1) = 0.060 μmol/mL, Bmax(1) = 0.093 μmol/mg for the higher affinity binding sites, and Kd(2) = 0.455 μmol/mL, Bmax(2) = 0.248 μmol/mg for the lower affinity binding sites. Non-imprinted polymer has only one class of
Naftifine (brand name Exoderil) is an allylamine antifungal drug for the topical treatment of tinea pedis, tinea cruris, and tinea corporis (fungal infections). Naftifine has triple action: antifungal, antibacterial and anti-inflammatory. Its precise mechanism of action is unknown, but may involve selectively blocking sterol biosynthesis via inhibition of the squalene 2,3-epoxidase enzyme. The half-life is approximately 2-3 days. The metabolites are excreted in the urine and feces. Robertson Dirk B, Maibach Howard I, Chapter 61. Dermatologic Pharmacology (Chapter). Bertram G. Katzung, Susan B. Masters, Anthony J. Trevor: Basic & Clinical Pharmacology, 11e: http://www.accesspharmacy.com/content.aspx?aID=4517257. Micromedex DRUGDEX Drug Point: Naftifine Hydrochloride. Accessed at www.thomsonhc.com/../BeginWith#secN10184, February 18, 2010. AccessPharmacy: Drug Monographs: Naftifine. Accessed at http://www.accesspharmacy.com/drugContentPopup.aspx?mid=6620§ion=10, February 18, 2010 ...
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice ...
Single-center, randomized, parallel, double-blind, placebo controlled, 8-week trial in subjects with type 2 diabetes mellitus. Two parallel treatment groups include double-blind colesevelam or placebo. A screening period may be up to 18 weeks to withdraw non sulfonylurea antidiabetic treatment or withdraw or adjust sulfonylurea antidiabetic treatment. To evaluate hepatic and peripheral insulin sensitivity, subjects will undergo a two-step hyperinsulinemic-euglycemic clamp with a tritiated glucose infusion at pre randomization and after 8 weeks of treatment. To evaluate oral glucose absorption, subjects will undergo two oral glucose tolerance tests (OGTT) at pre randomization, one without colesevelam and one with colesevelam, and one OGTT at the end of the treatment period ...
Colesevelam - Get up-to-date information on Colesevelam side effects, uses, dosage, overdose, pregnancy, alcohol and more. Learn more about Colesevelam
The only disclosure restriction on the PI is that the sponsor can review results communications prior to public release and can embargo communications regarding trial results for a period that is more than 60 days but less than or equal to 180 days. The sponsor cannot require changes to the communication and cannot extend the embargo ...
Constipation: Colesevelam may cause or worsen constipation. Fecal impaction (a large mass of stool that may be lodged in the colon) and worsening of hemorrhoids may occur. Talk to your doctor as soon as possible if any of these side effects become bothersome.. Drug interactions: Colesevelam can interact with other medications, such as birth control pills, cyclosporine, and warfarin (see What medications can interact with colesevelam? for more medications). If you take any of these medications, you should wait at least 4 hours before taking colesevelam. Your doctor will monitor you and the other medications you are taking while you are taking colesevelam. In general, if a drug interaction cannot be ruled out, you should take colesevelam at least 4 hours after your other medications in order to lessen the risk of the other medications not being fully absorbed into the body. Gastrointestinal: The safety and efficacy of colesevelam have not been established for people with swallowing problems, ...
Terbinafine is an allylamine antifungal medication. The medication can be administered orally or topically as a cream. The topical treatment was officially approved by the FDA in 1993 and can be bought over the counter. The oral treatment was approved in 1996 and widely distributes in the central nervous system, hair and nail beds and may remain there for up to three months because of extended elimination from skin and adipose tissue. Terbinafine is metabolized in the liver and 70% is excreted in the urine.. Mechanism: Terbinafine has a fungicidal effect by inhibiting the enzyme squalene monooxygenase which is involved in the synthesis of sterol in fungi. This inhibits fungal sterol biosynthesis by decreasing ergosterol levels. Fungal membranes are not able to grow because ergosterol is one of the main components of the fungal cell membrane. Additionally, squalene accumulates which weakens the cell membrane. Orally, the drug is very effective due to its ability to concentrate within the ...
Compare Simvastatin vs Atorvastatin vs Lipitor vs Colesevelam head-to-head with other drugs for uses, ratings, cost, side effects, interactions and more. Simvastatin rated 5.1/10 vs Atorvastatin rated 4.4/10 vs Lipitor rated 4.7/10 vs Colesevelam rated 8.3/10 in overall patient satisfaction.
Introduction Bile acid sequestrants (BAS) were the first class of lipid-lowering drug to be developed for reducing blood cholesterol levels.1 Now, after their introduction 30 years ago, BAS still continue to command a position in the treatment of hyperlipidaemia.2 How do BAS work? BAS bind to negatively charged b ...
Monday - 13th March 2017 - off to see my GP to get a prescription for Colesevelam, a bile acid sequestrant. He greeted me with bloody hell, you look well! I didnt understand the reason for his comment until later. We agreed on the new drug and he also reviewed my existing medications. So far so good.. He had been reading my medical record, the last entry of which was a trip to A&E with jaundice. He had assumed that I was back to see him with a recurrence of the problem, hence his comment. He asked me what the plan was following discharge back at the beginning of February. As far as I was concerned I had undergone a follow-up ultrasound scan and it was now matter closed. Clearly he thought there should have been some follow-up. He was rather miffed that I had heard nothing and said that he would chase it up.. We then had a fairly lengthy discussion on gallstones and surgery to have my gallbladder removed. That was a bit of a shock. I had gone in to get a prescription and come away with a ...
TY - JOUR. T1 - Terbinafine inhibits endothelial cell migration through suppression of the Rho-mediated pathway. AU - Ho, Pei Yin. AU - Zhong, Wen-Bin. AU - Ho, Yan Soon. AU - Lee, Wen Sen. PY - 2006/12. Y1 - 2006/12. N2 - We showed previously that terbinafine, an allylamine with fungicidal activity, could inhibit angiogenesis by suppressing the endothelial cell proliferation. In the present study, we further showed that terbinafine (0-120 μmol/L) dose dependently inhibited the adhesion and migration of human umbilical vascular endothelial cells (HUVEC). Western blot analysis showed that terbinafine decreased the levels of Ras protein and membrane-bound RhoA protein. Moreover, the terbinafine-induced migration inhibition in HUVEC was prevented by pretreatment with farnesol or geranylgeraniol. Pretreatment of HUVEC with Ras inhibitor peptide or a ROCK (a kinase associated with RhoA for transducing RhoA signaling) inhibitor, Y27632, abolished the farnesol- or geranylgeraniol-induced prevention ...
It is also important to look for any other co-existing infection that might need to be treated at the same time, such as secondary bacterial infection of a fungal rash or a fungal infection occurring elsewhere on the body.. Most fungal skin infections can be successfully treated with an appropriate topical antifungal such as, for example, an azole or allylamine.. Oral antifungal medication is generally only required if the infection is particularly extensive or severe, if it is resistant to topical antifungal therapy, or sometimes if it affects certain hair-bearing areas such as the scalp.. The choice of topical azole depends on both the characteristics of the rash and the likely pathogen, as well as the relative antibacterial and anti-inflammatory effects of the medication.. Click here to read more in the article published on Sep 2016 by Professor Rodney Sinclair.. ...
Layer-by-layer structures (e.g. polyelectrolyte multilayers and protein-polyelectrolyte multilayers) play a very important role in surface modification processes. In the present study, electrokinetic measurements were applied for the investigation of poly(allylamine hydrochloride)/poly(sodium 4-styrenesulphonate) (PAH/PSS) multilayer formation, with PAH being a terminal layer, as a function of pH. Additionally, the effect of supporting electrolyte (KCl) concentration on multilayer formation was tested. Silica particles were used as the solid substrate. Furthermore, the adsorption of bovine serum albumin (BSA) on previously formed multilayer was examined as a function of pH and BSA concentration. It was confirmed that the electrokinetic measurements are suitable for monitoring the formation of various multilayers. In all investigated systems the process of multilayer formation was found to depend on conditions (ionic strength and pH) under which the multilayer was formed. Moreover, in the case of ...
The layer-by-layer ionic self-assembly of silica nanoparticles (SiO2 NPs) and poly(allylamine hydrochloride) (PAH) can yield high-quality, tunable, and cost-effective anti-reflection coatings (ARCs). However, these purely ionic films lack the necessary scratch resistance for long-term stability. The addition of the
Stroke causes extensive cellular loss that leads to a disintegration of the afflicted brain tissue. Although transplanted neural stein cells can recover some of the function lost after stroke, recovery is incomplete and restoration of lost tissue is minimal. The challenge therefore is to provide transplanted cells with matrix support in order to optimise their ability to engraft the damaged tissue. We here demonstrate that plasma polymerised allylamine (ppAAm)-treated poly(D,L-lactic acid-co-glycolic acid) (PLGA) scaffold particles can act as a structural support for neural stem cells injected directly through a needle into the lesion cavity using magnetic resonance imaging-derived co-ordinates. Upon implantation, the neuro-scaffolds integrate efficiently within host tissue forming a primitive neural tissue. These neuro-scaffolds could therefore be a more advanced method to enhance brain repair. This study provides a substantial step in the technology development required for the translation of ...
Described and claimed are biologically useful crosslinked copolymers of vinyl pyrrolidone and allylamine suitable for various preventative and therapeutic applications to intact or injured skin. Coatings of these copolymers, either preformed or prepared in situ on the skin may deliver medicaments to the skin, may serve as an iontophoretic medium, may provide electrical contact with the body, may regulate or control moisture loss from injured integument. Monolithic devices for the delivery of pharmaceutically active agents within living tissue may be formulated from these copolymers.
TY - JOUR. T1 - Adult rat myocardial slices. T2 - A tool for studies of comparative cardiotoxicity. AU - Parrish, A. R.. AU - Dorr, Robert T. AU - Gandolfi, A Jay. AU - Brendel, K.. PY - 1994. Y1 - 1994. N2 - The applicability of myocardial slices in comparative cardiotoxicity studies was investigated using the known cardiotoxicants allylamine (AAM) and doxorubicin (DOX). Precision-cut adult rat myocardial slices are a recently developed in vitro system. Previously, it has been demonstrated that myocardial slices are viable for up to 24 hr in organ culture. Myocardial slices exhibited a concentration- and time-dependent loss of viability in response to exposure to AAM or DOX (10-7, 10-6 or 10-5 m) during 24 hr in culture, as assessed by biochemical parameters including protein synthesis, ATP content, lipid peroxidation and the loss of the cytosolic enzyme creatine kinase. Protein synthesis and ATP content were sensitive indicators of slice viability, while lipid peroxidation was affected only by ...
We present a detailed structural and surface-enhanced Raman scattering (SERS) study of poly(allylamine) modified with Os (byp)2 ClPyCHO (PAH-Os) and gold nanoparticles self-assembled multilayers [PAH-Os+ (Au-nanoparticlesPAH-Os)n, n=1 and 5]. Atomic force microscopy and variable-angle spectroscopic ellipsometry measurements indicate that the first nanoparticle layer grows homogenously by partially covering the substrate without clustering. Analyzing the sample thickness and roughness we infer that the growth process advances thereafter by filling with nanoparticles the interstitial spaces between the previously adsorbed nanoparticles. After five immersion steps the multilayers reach a more compact structure. The interaction between plasmons of near-gold nanoparticles provides a new optical absorption around 650 nm which, in addition, allows a more effective SERS process in that spectral region than at the single-plasmon resonance (∼530 nm). We compare the electronic resonance Raman and SERS ...
A novel route to cyclic imines based on 5-exo radical cyclization is explored. The radical precursors are imines prepared from allylamine and readily available alpha-phenylselenenyl ketones.. ...
RESULTS Fasting plasma glucose and HbA1c decreased with colesevelam (from 5.9 ± 0.1 to 5.7 ± 0.1 mmol/L, P , 0.05, and from 5.86 ± 0.06 to 5.76 ± 0.06%, P = 0.01, respectively), but fasting insulin did not change. Colesevelam had no effect on any FSIGT measures. In contrast, the MTT incremental area under the curve (iAUC) for both glucose (from 249.3 ± 28.5 to 198.8 ± 23.6 mmol/L ⋅ min, P , 0.01) and insulin (from 20,130 [13,542-35,292] to 13,086 [9,804-21,138] pmol/L ⋅ min, P , 0.05) decreased with colesevelam. However, the ratio of iAUC insulin to iAUC glucose was not changed. iAUC for cholecystokinin (CCK) increased (from 43.2 [0-130.1] to 127.1 [47.2-295.2] pmol/L ⋅ min, P , 0.01), while iAUC for fibroblast growth factor 19 decreased (from 11,185 [1,346-17,661] to 2,093 [673-6,707] pg/mL ⋅ min, P , 0.01) with colesevelam. However, iAUC for glucagon, glucose-dependent insulinotropic peptide, and glucagon-like peptide 1 did not change. ...
Find information on Colesevelam (Welchol) in Daviss Drug Guide including dosage, side effects, interactions, nursing implications, mechanism of action, half life, administration, and more. Davis Drug Guide PDF.
Medscape - Indication-specific dosing for WelChol (colesevelam), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information.
In a final effort to get the yellow out of my water, I tried a third brand of sequestrant/chelating agent, Sequa-Sol It worked. The water is the best looking it has been to date. The previous two were Metal Free and Sea Klear Metal Klear. The MSDS on this new one says the active ingredient is Sodium Citrate. It is listed as a chelating agent where the previous two used Acrylamide-Acrylic Acid Copolymer, listed as a sequestrant. I cant find much that explains the difference, at least as
Lodalis Tablet is used for high cholesterol levels, high cholesterol and other conditions. Lodalis Tablet contains the following active ingredients: Colesevelam Hydrochloride.
Cholesterol-lowering drugs are known as antihyperlipidemic agents. There are five major groups: (1) Fibric acid derivatives - Atromid-S (clofibrate) and Lopid (gemdibrozil), which work by preventing the liver from making or releasing cholesterol into the bloodstream, (2) Bile acid sequestrants - Questran (cholestryamine) and Colestid (cholestipol), which bind to bile acids and prevent their absorption, (3) Nicotinic acid - Nicolar (nicotinic acid), which decreases the secretion of VLDL thus the formation of bad LDL cholesterol, (4) Probucol - Lorelco (probucol), which enhances the clearance of cholesterol including LDL and HDL cholesterol, and (5) HMG-CoA reductase inhibitors - Mevacor (lovastatin), Pravastatin, and Zocor (simvastatin), which work to help lower LDL cholesterol ...
We included five RCTs enrolling a total of 203 participants. Of these, four studies compared statins with no treatment or placebo, and one compared fibrates with placebo. We found no published studies comparing second-line agents such as ezetimibe, bile acid sequestrants, and nicotinic acid with placebo or no treatment. Our assessment of the risk of bias found that one study was judged overall to be at low risk of bias and the remaining four were judged to be at high risk of bias.. Most outcomes were supported by single study data. One study reported significantly increased high density lipoprotein (HDL) cholesterol among participants in the statin arm compared with the no treatment group (MD 5.40 mg/dL, 95% CI 2.31 to 8.49). Another study reported higher serum albumin in the statin group compared to those who received no treatment (MD 0.60 g/dL, 95% CI 0.14 to 1.06). No serious adverse events, such as rhabdomyolysis, were reported, however some minor events occurred. One study reported no ...
Drugs to reduce cholesterol and other lipids in blood. Classes of drugs used for this purpose include statins, bile acid sequestrants, nicotinic acid, and fibrates.
There is no known cure, but medication may slow the progression so that a normal lifespan and quality of life may be attainable. Ursodeoxycholic acid (Ursodiol) is one, which helps reduce the cholestasis. To relieve itching caused by bile acids in circulation, which would normally be removed by the liver, cholestyramine (a bile acid sequestrant) may be prescribed to absorb bile acids in the gut and be eliminated, rather than enter the blood stream. As in all liver diseases, alcoholic beverages are contraindicated. In advanced cases, a liver transplant, if successful, is said to have excellent prognosis. ...
The strategy underlying the addition of a second or third agent is to optimize improvements in the lipid profile achieved by initial (usually statin) therapy. This strategy is based on the empirical assumption that further improvement in the lipid profile beyond that initially achieved will yield additional CVD benefit. However, there are as yet no controlled clinical trials comparing statin monotherapy with combination treatment.. It has been clearly shown that the addition of ezetimibe to a statin will lower LDL cholesterol to goal more often than statin monotherapy will.28 Bile acid sequestrants may also help to lower LDL cholesterol but should be used with caution because they have a triglyceride-raising effect in hypertriglyceridemic patients.29. It is also clear that achievement of all three lipid goals is more likely with statin plus fibrate or statin plus niacin combinations.30-32 However, the added complexity and risks of combination therapy in the absence of persuasive clinical trial ...
There are several alternatives to Advicor, including other statins or cholesterol medicines. As this eMedTV page explains, besides statins, other cholesterol medicines include fibrates, cholesterol absorption inhibitors, and bile acid sequestrants.
Vytorin alternatives often include statins or other cholesterol medicines. This eMedTV article lists various types of statins and other classes of cholesterol medications, such as bile acid sequestrants, fibrates, and niacin.
Bile acid sequestrants and nicotinic acid have cholesterollowering properties. They may occasionally be useful alone or in combination with statin therapy. However, their side-effects limit wider application.. 8.8 Treatment directed at other components of the lipid profile. Whereas low levels of HDL-C and high levels of TG are undoubtedly associated with a higher cardiovascular disease risk, no currently available treatment directed at reversing these changes has been shown to significantly benefit cardiovascular outcome.. A high triglyceride level, particularly if ,10 mmol/l, can result in acute pancreatitis and should be treated without delay.. 9. Special circumstances. 9.1 Metabolic syndrome. The European Guidelines recognise the importance of identifying patients with the metabolic syndrome, who are at increased risk of cardiovascular disease. The presence of the syndrome approximately doubles the risk of cardiovascular disease. Lifestyle changes, particularly reducing body weight and ...
Possesses an unusual and selective cytotoxicity for Vascular Smooth Muscle Cells in Dogs and Rats. Useful for experiments dealing with arterial injury, myocardial Fibrosis or cardiac decompensation ...
Silicon quantum dots have been synthesized in micelles. Particle sizes have been ascertained by transmission electron microscopy and UV-Vis absorption and photoluminescence spectroscopy. The surface of the silicon and germanium particles produced have been modified to produce hydrophobic and hydrophilic particles by reaction with either with 1-heptene or allylamine respectively. For biological applications control of the surface character of the nanocrystals is essential. FTIR spectra show the surface modification of the particles by 1-heptene or allylamine ...
Colesevelam: Find the most comprehensive real-world treatment information on Colesevelam at PatientsLikeMe. 5 patients with fibromyalgia, multiple sclerosis, major depressive disorder, generalized anxiety disorder, diabetes type 2, post-traumatic stress disorder, systemic lupus erythematosus, bipolar disorder, Parkinsons disease, panic disorder, rheumatoid arthritis, high blood pressure (hypertension), myalgic encephalomyelitis/chronic fatigue syndrome, persistent depressive disorder (dysthymia), amyotrophic lateral sclerosis, epilepsy, migraine, hypothyroidism, osteoarthritis, traumatic brain injury, attention deficit/hyperactivity disorder, bipolar II disorder, asthma, social anxiety disorder, high cholesterol (hypercholesterolemia), irritable bowel syndrome, idiopathic pulmonary fibrosis, gastroesophageal reflux disease, bipolar I disorder or psoriasis currently take Colesevelam.
Saccharomyces cerevisiae squalene epoxidase contains two highly conserved motifs, 1 and 2, of unknown function. Amino acid substitutions in both regions reduce enzyme activity and/or alter allylamine sensitivity. In the homology model, these motifs flank the flavin adenine dinucleotide cofactor and form part of the interface between cofactor and substrate binding domains ...
TY - JOUR. T1 - Nanoscale control of layer thickness for EL devices by mass-controlled layer-by-layer sequential adsorption process. AU - Shiratori, Seimei. AU - Yamada, Masayoshi. AU - Ito, Takahiro. AU - Wang, Tom C.. AU - Rubner, Michael F.. PY - 2000/12/1. Y1 - 2000/12/1. N2 - A mass controlled layer-by-layer sequential adsorption process for polyelectrolytes was newly developed for the fabrication of functional devices using ultra-thin organic film formed by various polymers of different polarity of charge. In this study hydrophobic Ruthenium complex monomer (tris(bipyridyl) ruthenium(II) hexafluorophosphate) was micelle-wrapped with an anionic surfactant, sodium dodecylbenzenesulfonate, and was assembled with PAH (poly (allylamine hydrochloride)), which has the opposite charge, on ITO substrates. With this method, we succeeded in fabricating ultra-thin organic films even when the adsorption material is not polymer but monomer. Moreover it was found that the film thickness of the ...
Nanoparticles made from poly(dl-lactide-co-glycolide) (PLGA) are used to deliver a wide range of bioactive molecules, due to their biocompatibility and biodegradability. This study investigates the surface modification of PLGA nanoparticles via the layer-by-layer (LbL) deposition of polyelectrolytes, and the effects of these coatings on the release behavior, cytotoxicity, hemolytic activity, and cellular uptake efficiency. PLGA nanoparticles are modified via LbL adsorption of two polyelectrolyte pairs: 1) poly(allylamine hydrochloride) (PAH) and poly(styrene sulfonate) (PSS) and 2) poly(L-lysine hydrobromide) (PLL) and dextran sulfate (DES). It is demonstrated that both PAH/PSS and PLL/DES coatings suppress the burst release usually observed for unmodified PLGA nanoparticles and that the release behavior can be adjusted by changing the layer numbers, layer materials, or by crosslinking the layer constituents. Neither bare nor polyelectrolyte-modified PLGA nanoparticles show any signs of ...
Dr. Lin Han, assistant professor in BIOMED, will discuss how polyelectrolytes effectively reduce surface friction by decreasing surface contact adhesion, and creating a fluid-like hydration sheath surrounding charged groups. Utilizing lateral force microcopy, Dr. Han and his team investigated the mechanisms and environmental factors that can quantitatively control the magnitude of polyelectrolyte surface friction coefficient, μ, at nano- to micrometer deformation length scales. In the first model system, with a microspherical tip, lateral force microscopy was utilized to measure the friction of an end-attached monolayer of the comb-like, negatively charged, biomacromolecules extracted from articular cartilage, aggrecan. In a second model system, we studied the layer-by-layer assembled poly(allylamine hydrochloride) / poly(acrylic acid) (PAH/PAA) in various microscale geometries (planar film versus tube forest). Understanding these environmental factors provides a platform to design dynamic substrates
This work reports a novel deltamethrin (DM) sensor able to detect nano-molar concentrations in ethanol solutions. The sensing layer consists of a thin film, obtained via a layer-by-layer technique, from alternate adsorption of poly(allylamine chloride) (PAH) and poly[1-[4-(3-carboxy-4-hydroxyphenylazo)-benzenesulfonamide)-1,2-ethanediyl]sodium salt] (PAZO) onto a solid support with interdigitaded gold electrodes. The sensor response, obtained from impedance spectroscopy measurements, was revealed to be linear with respect to the real part of impedance, taken at 100 Hz, when plotted as a function of the logarithm of deltamethrin molar concentrations in the micro- to nano-molar range. Sensor sensitivity was of 41.1 ± 0.7 kΩ per decade of concentration for an immersion time above 2 min and the reproducibility is approximately 2% in a binary solution of ethanol and deltamethrin. The main insight of this work concerns to DM detection limits as the sensor revealed to be able to detect concentrations below
Overview of Services Tinea versicolor can be successfully treated with various agents. [30] Effective topical agents include selenium sulfide, zinc-pyrithione, sodium sulfacetamide, ciclopirox olamine, [31] , tacrolimus, [32] as well as azole and allylamine antifungals. [33, 34, 35, 36, 37] Even if a small area of skin is involved, treating with topicals from the neck to the knees may make treatment more successful. [14] Various regimens can be used. Selenium sulfide lotion is liberally applied to affected areas of the skin daily for 2 weeks; each application is allowed to remain on the skin for at least 10 minutes prior to being washed off. In resistant cases, overnight application can be helpful. Topical azole antifungals can be applied every night for 2 weeks. Weekly application of any of the topical agents for the following few months may help prevent recurrence. In patients with widespread disease, some topical antifungal therapy can be expensive. Over-the-counter shampoo formulations of ...
Triazole and allylamine antifungal drugs have mostly replaced griseofulvin and ketoconazole as first-line medications in the therapy of nail fungus. Making use
Watson, through subsidiary Watson Labs, said it applied for approval of a generic version of Daiichi Sankyos and Genzymes Welchol (colesevelam hydrochloride). The drug, a powdered oral suspension, is used to reduce bad LDL cholesterol in patients with primary hyperlipidemia, either alone or in combination with a statin.. Watsons application included a Paragraph IV certification, a legal assertion that the patents covering Welchol are invalid, unenforceable or not vulnerable to infringement. Under the terms of the Hatch-Waxman Act of 1984, Daiichi Sankyo and Genzyme have filed suit against Watson in the U.S. District Court for the District of Delaware, putting a stay of final Food and Drug Administration approval on the drug until June 2013, or until the companies reach a settlement.. ...
A first piece of evidence for a link between bile acid and glucose metabolism came from a short-term study in patients with noninsulin-dependent diabetes mellitus (NIDDM) or type II diabetes.114 Patients with high LDL cholesterol but normal triglyceride levels, using either glyburide or insulin to control glycemia, were treated with cholestyramine or placebo. Cholestyramine treatment lowered plasma glucose by 13% and decreased urinary glucose excretion, with a tendency toward lower glycosylated hemoglobin concentrations. At the same time, cholestyramine reduced total and LDL cholesterol and increased triglyceride levels. This study therefore identified bile acid sequestrants, which are not absorbed, as a potential option to treat type II diabetes. It will be of interest to determine whether the ASBT inhibitors, like S 8921115 or SC 435,116 that selectively interfere with bile acid reabsorption also regulate glycemia in diabetic patients. Nevertheless, because an increase of unbound bile acids ...
FH is usually treated with statins.[7] Statins act by inhibiting the enzyme hydroxymethylglutaryl CoA reductase (HMG-CoA-reductase) in the liver. In response, the liver produces more LDL receptors, which remove circulating LDL from the blood. Statins effectively lower cholesterol and LDL levels, although sometimes add-on therapy with other drugs is required, such as bile acid sequestrants (cholestyramine or colestipol), nicotinic acid preparations or fibrates.[2] Control of other risk factors for cardiovascular disease is required, as risk remains somewhat elevated even when cholesterol levels are controlled. Professional guidelines recommend that the decision to treat a person with FH with statins should not be based on the usual risk prediction tools (such as those derived from the Framingham Heart Study), as they are likely to underestimate the risk of cardiovascular disease; unlike the rest of the population, FH have had high levels of cholesterol since birth, probably increasing their ...
Beta carotene, vitamin K, vitamin C, an calcium is rowth in kail. Kail is a soorce o twa carotenoids, lutein an zeaxanthin.[1] Kail, as wi broccoli an ither brassicas, conteens sulforaphane (parteecular whan its been chappit or minced), a chemical wi potent anti-cancer properties.[2] Bylin lawers the leevel o sulforaphane; housomeiver, steamin, microwavin, or stir fryin disna cause a important loss.[3] Lik ither brassica vegetables, kail is a soorce o indole-3-carbinol an aw, a chemical that forders DNA repair in cells an appears tae keep cancer cells fae growin.[4][5] Kail haes been foond tae conteen a group o resins cried bile acid sequestrants, that haes been shawn tae lawer cholesterol an lawer absorption o dietary fat. Steamin signeeficantly accresses thir bile acid bindin properties.[6] ...
5TZ1: Structural analyses of Candida albicans sterol 14 alpha-demethylase complexed with azole drugs address the molecular basis of azole-mediated inhibition of fungal sterol biosynthesis.
Fingerprint Dive into the research topics of In vitro and in vivo antidermatophyte activities of NND-502, a novel optically active imidazole antimycotic agent. Together they form a unique fingerprint. ...
With Dougs comments and revisiting all of the above, Im going to experiment again with putting the stretch-position exercise first in my bodypart routines. I say again because we tried that years ago. In fact, it worked so well we created a video titled Hypercontraction Training. Lots of trainees reported excellent mass gains-but it fell out of favor. Why? Because strength was sluggish on the big midrange exercises, which were performed after a few sets of a stretch-position exercise. We thought because strength wasnt increasing, it wasnt working well. Wrong… ...
Allylamines[edit]. Allylamines[3] inhibit squalene epoxidase, another enzyme required for ergosterol synthesis. Examples ... Tolnaftate - a thiocarbamate antifungal, which inhibits fungal squalene epoxidase (similar mechanism to allylamines like ... "Research and Markets: Global Antifungal Therapeutics (Polyenes, Azoles, Echinocandins, Allylamines) Market:Trends and ...
Hydrolysis of allyl isothiocyanate gives allylamine. Allyl isothiocyanate has an LD50 of 151 mg/kg and is a lachrymator ( ... Leffler, M. T. (1938). "Allylamine". Organic Syntheses. 18: 5.; Collective Volume, 2, p. 24 Zhang, Y (2010). "Allyl ...
... is an antimicrobial medication used to treat African trypanosomiasis, leishmaniasis, Balamuthia infections,[2] babesiosis, and to prevent and treat pneumocystis pneumonia (PCP) in people with poor immune function.[1] In African trypanosomiasis it is used for early disease before central nervous system involvement, as a second line option to suramin.[1] It is an option for both visceral leishmaniasis and cutaneous leishmaniasis.[1] Pentamidine can be given by injection into a vein or muscle or by inhalation.[1] Common side effects of the injectable form include low blood sugar, pain at the site of injection, nausea, vomiting, low blood pressure, and kidney problems.[1] Common side effects of the inhaled form include wheezing, cough, and nausea.[1] It is unclear if doses should be changed in those with kidney or liver problems.[1] Pentamidine is not recommended in early pregnancy but may be used in later pregnancy.[1] Its safety during breastfeeding is unclear.[3] Pentamidine is in the ...
The substance appears to have a slight toxicity in higher doses, with effects such as liver and intestinal disorders at high exposure in test animals (just below LD50 level).[citation needed] Some reproductive disorders and decreasing weaning weight have been observed, also at high exposure. Effects on humans from use as a drug include nausea, vomiting, loss of appetite, diarrhea, dizziness, drowsiness, or headache; very rarely also ringing in the ears, vision changes, stomach pain, yellowing eyes and skin, dark urine, fever, fatigue, increased thirst and change in the amount of urine occur.[citation needed] Carcinogenic effects have been shown at higher doses.[11] ...
It is commonly available without a prescription in various dosage forms, such as a topical cream, ointment, or vaginal suppository. It is also available as an oral troche or throat lozenge as a prescription only. Topically, clotrimazole is used for vulvovaginal candidiasis (yeast infection) or yeast infections of the skin. For vulvovaginal candidiasis (yeast infection), clotrimazole tablets and creams are inserted into the vagina. Topical clotrimazole is usually not effective in treatment of fungal infections of the scalp or nails.[citation needed] When using over-the-counter drug clotrimazole products, use should be discontinued if condition does not improve after treatment for 2 weeks for jock itch or after 4 weeks for athlete's foot or ringworm.[6] Throat lozenge preparations are used for oropharyngeal candidiasis (oral thrush) or prevention of oral thrush in people with neutropenia.[6] Clotrimazole is usually used 5 times daily for 14 days for oral thrush, twice daily for 2 to 8 weeks for ...
InChI=1S/C58H73N7O17/c1-5-6-7-24-82-40-22-18-35(19-23-40)33-10-8-32(9-11-33)34-12-14-37(15-13-34)51(74)59-41-26-43(70)54(77)63-56(79)47-48(71)29(2)27-65(47)58(81)45(31(4)67)61-55(78)46(50(73)49(72)36-16-20-38(68)21-17-36)62-53(76)42-25-39(69)28-64(42)57(80)44(30(3)66)60-52(41)75/h8-23,29-31,39,41-50,54,66-73,77H,5-7,24-28H2,1-4H3,(H,59,74)(H,60,75)(H,61,78)(H,62,76)(H,63,79)/t29-,30+,31+,39+,41-,42?,43+,44?,45?,46?,47?,48-,49+,50+,54+/m0/s1 ...
... , also known as selenium sulfide, is a medication used to treat pityriasis versicolor, seborrhoeic dermatitis, and dandruff.[1] It is applied to the affected area as a lotion or shampoo.[2] Dandruff frequently returns if treatment is stopped.[3] Side effects include hair loss, irritation of the skin, weakness, and feeling tired.[1] Use is not recommended in children less than 2-5 years old.[3][1] Use in pregnancy or breastfeeding has not been studied.[4] Selenium disulfide is an inorganic compound with the chemical formula SeS2.[5] Selenium disulfide was approved for medical use in the United States at least as early as 1951.[3] It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system.[6] Selenium disulfide is available as a generic medication and over the counter.[2] In the United States a month of treatment costs less than 25 USD.[2] In the United Kingdom 100 ml of 2.5% shampoo costs the NHS about ...
... (trade names Oxistat in the US, Oxizole in Canada) is an antifungal medication typically administered in a cream or lotion to treat skin infections, such as athlete's foot, jock itch and ringworm. It can also be prescribed to treat the skin rash known as tinea versicolor, caused by systemic yeast overgrowth (Candida spp.). ...
... has been used for decades in the food industry as a hurdle to fungal outgrowth in dairy products and other foods. Potential advantages for the usage of natamycin might include the replacement of traditional chemical preservatives, a neutral flavor impact, and less dependence on pH for efficacy, as is common with chemical preservatives. It can be applied in a variety of ways: as an aqueous suspension (such as mixed into a brine) sprayed on the product or into which the product is dipped, or in powdered form (along with an anticaking agent such as cellulose) sprinkled on or mixed into the product. While not currently approved for use on meats in the United States, some countries allow natamycin to be applied to the surface of dry and fermented sausages to prevent mold growth on the casing. Also, natamycin is approved for various dairy applications in the United States. More specifically, natamycin is commonly used in products such as cream cheeses, cottage cheese, sour cream, yogurt, ...
Lin, K.-F.; Lin, J.-S.; Cheng, C.-H. (1996). "High temperature resins based on allylamine/bismaleimides". Polymer. 37 (21): ...
Poly(allylamine hydrochloride) has many biomedical applications. The most prominent use of this polyelectrolyte is in the field ... 71550-12-4) is a cationic polyelectrolyte prepared by the polymerization of allylamine. It can be used in combination with an ...
An LbL formation of PEM (PSS-PAH (poly(allylamine) hydrochloride)) on a gold substrate can be seen in the Figure. The formation ... "Metal Complexes of Amphoteric Cryogels Based on Allylamine and Methacrylic Acid". Macromolecular Symposia. 317-318: 18-27. doi: ...
Like the allylamine antifungals, butenafine works by inhibiting the synthesis of ergosterol by inhibiting squalene epoxidase, ... It is structurally related to synthetic allylamine antifungals such as terbinafine. Butenafine is indicated for the topical ...
... is in the allylamines family of medications. It works by decreasing the ability of fungi to make sterols. It ... Like other allylamines, terbinafine inhibits ergosterol synthesis by inhibiting squalene epoxidase, an enzyme that catalyzes ...
Both systems produced the desired allyl amines in high yield, which contain an alkene that can be further functionalized ... The isolation and characterization of the rarer and more synthetically valuable kinetic allyl amine product was reported when ... Functionalized allylamines, which can be produced through hydroamination, have extensive pharmaceutical application, although ... Hydroamination has been utilized to synthesize the allylamine Cinnarizine in quantitative yield. Cinnarizine treats both ...
Its formation can be associated with a reaction with an allylamine and various reagents via heck coupling are able to remove ... Aminoallyl nucleotide is a nucleotide with a modified base containing an allylamine. They are used in post-labeling of nucleic ... the halogen group from the base and add the allylamine to become the aminoallyl nucleoside shown on the right. The product on ...
Nubbemeyer, U. (1995). "1,2-Asymmetric Induction in the Zwitterionic Claisen Rearrangement of Allylamines". J. Org. Chem. 60 ( ...
CH2=CHCH2Cl + NaNH2 → C3H4 (cyclopropene) + NaCl + NH3 The major byproduct of the reaction is allylamine. Adding allyl chloride ...
Diethylthiambutene Tipepidine U.S. Patent 2,561,899 - Dithienyl Allyl Amines v t e. ...
... allylamine hydrochloride) composite". Journal of Colloid and Interface Science. 396: 258-263. doi:10.1016/j.jcis.2013.01.023. ...
In particular, Si quantum dots with poly (acrylic acid) and allylamine shells have been used in cell labeling. Other in vitro ...
Synthesis of allyl amines Petasis and coworkers proposed, in their seminal study, that vinyl boronic acids can react with the ... In comparison to other methods of generating allyl amines, the Petasis reaction tolerates a multifunctional scaffold, with a ... the corresponding allylamine is formed as a single diastereomer. Furthermore, enantiomeric purity can be achieved by ... A new method for the synthesis of geometrically pure allylamines". Tetrahedron Lett. 34 (4): 583-586. doi:10.1016/S0040-4039(00 ...
... they have found that vinyl boronic acids can participate as nucleophiles to give geometrically pure allylamines. This modified ... A new method for the synthesis of geometrically pure allylamines". Tetrahedron Letters. 34 (4): 583-586. doi:10.1016/S0040-4039 ...
Studies suggest that allylamines (naftifine and terbinafine) are a quicker but more expensive form of treatment compared to ... Tinea cruris is treated with by applying antifungal medications of the allylamine or azole type to the groin region. ...
The compound is a reagent in the Doyle-Kirmse reaction with allyl sulfides and allyl amines. Trimethylsilyldiazomethane is ...
"Research and Markets: Global Antifungal Therapeutics (Polyenes, Azoles, Echinocandins, Allylamines) Market:Trends and ... similar mechanism to allylamines like terbinafine)[medical citation needed] Undecylenic acid - an unsaturated fatty acid ... Fluconazole Isavuconazole Itraconazole Posaconazole Propiconazole Ravuconazole Terconazole Voriconazole Abafungin Allylamines ...
Allylamines such as terbinafine are considered more efficacious than azoles for the treatment of athlete's foot. Severe or ...
Allylamine Hydrochloride) and Magnesium Ions". Chemistry of Materials. 25 (24): 4994-5003. doi:10.1021/cm403497g. ISSN 0897- ...
The resulting allylamine structures can be transformed into many chemically and biologically important natural and un-natural ...
... (brand name Exoderil) is an allylamine antifungal drug for the topical treatment of tinea pedis, tinea cruris, and ...
"Synthesis of allylamine in ethanol". ResearchGate. Retrieved 2020-06-30. M. T. Leffler (1943). "Allylamine". Organic Syntheses ... Functionalized allylamines have extensive pharmaceutical applications. Pharmaceutically important allylamines include ... Allylamine, like other allyl derivatives is a lachrymator and skin irritant. Its oral LD50 is 106 mg/kg for rats. Nomenclature ... Allylamine is an organic compound with the formula C3H5NH2. This colorless liquid is the simplest stable unsaturated amine. All ...
Lachrymation. The substance is corrosive to the eyes, skin and respiratory tract. Corrosive on ingestion. Inhalation may cause lung oedema. See Notes. Exposure could cause severe swelling of the throat. The substance may cause effects on cardiovascular system and nervous system. This may result in cardiac disorders and impaired functions. The effects may be delayed. Medical observation is indicated ...
... constant met the requirements of the OECD principles for validity and falls within the applicability domain of allylamine. The ...
Allylamine. Regulatory process names 11 Translated names 26 CAS names 1 IUPAC names 9 Other identifiers 4 ...
Exposure of Sprague-Dawley rats to Allylamine, using a snout-only inhalation exposure system, for 6 hours a day for 7 ... Exposure of Sprague-Dawley rats to Allylamine, using a snout-only inhalation exposure system, for 6 hours a day for 7 ... Exposure of Sprague-Dawley rats to Allylamine, using a snout-only inhalation exposure system, for 6 hours a day for 7 ... Three groups, each comprising 5 male and 5 female Sprague Dawley rats, received Allylamine at target exposures of 5, 10 or 20 ...
Allylamine. Possesses an unusual and selective cytotoxicity for Vascular Smooth Muscle Cells in Dogs and Rats. Useful for ...
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice ...
Allylamines explanation free. What is Allylamines? Meaning of Allylamines medical term. What does Allylamines mean? ... Looking for online definition of Allylamines in the Medical Dictionary? ... allylamine. (redirected from Allylamines). Also found in: Encyclopedia. al·lyl·a·mine. (alil-ā-mēn), Member of a class of ... Allylamines , definition of Allylamines by Medical dictionary https://medical-dictionary.thefreedictionary.com/Allylamines ...
Antifungal Agents, Allylamine. Class Summary. These are fungicidal agents.. Terbinafine (Terbinex, Lamisil). *View full drug ...
Topical allylamines. Class Summary. These drugs are effective in treating a variety of fungal infections. Because they have ... Terbinafine is an allylamine derivative that inhibits squalene epoxidase, a key enzyme in sterol biosynthesis in fungi. This ...
Nanocapsules were prepared by mixing 1.3 mL of 3 mg mL−1 poly(allylamine hydrochloride), PAH (pKa = 8.6), with 0.5 mL of 1 mg ... Poly(allylamine hydrochloride) and Silica LUDOX® HS-40 Colloidal Silica, 40 wt% suspension in water, were obtained from Sigma- ... Nanocapsules were prepared by mixing poly(allylamine hydrochloride), (pKa = 8.6), with CU. The interaction of CU with PAH was ... Curcumin associated poly(allylamine hydrochloride)-phosphate self-assembled hierarchically ordered nanocapsules: size dependent ...
... allylamine hydrochloride) (PSS/PAH) and poly(acrylic acid)/poly(allylamine hydrochloride) (PAA/PAH). In both the systems, the ... 574d) Molecular Dynamics Simulations of Complex Formation Between Poly(styrene sulfonate) and Poly(allylamine hydrochloride), ... and Poly(acrylic acid) and Poly(allylamine hydrochloride). *Conference: AIChE Annual Meeting ...
The Role of ions in the plasma polymerization of allylamine.. Journal of Physical Chemistry B, 105(24) pp. 5730-5736. ... The objective of this study was to unravel the mechanism(s) by which allylamine plasma polymers form. The results are compared ... The radio-frequency-induced plasma polymerization of allylamine has been investigated in the plasma-gas phase by mass ... In the plasma-gas phase, evidence is provided for reactions between cations and intact neutral monomers (allylamine). These ...
Salinity Gradient Energy from Expansion and Contraction of Poly(allylamine hydrochloride) Hydrogels. Bui, Tri Quang; Cao, Vinh ... Poly(allylamine hydrochloride) hydrogels were cross-linked with glutaraldehyde to produce hydrogels with excellent expansion ...
Enantioenriched Homoaldol Products, Beta-Substituted Ketones, Isoxazolines, and Beta-Lactams Through Elaboration of Allylamine ... Enantioenriched Homoaldol Products, Beta-Substituted Ketones, Isoxazolines, and Beta-Lactams Through Elaboration of Allylamine ... Enantioenriched Homoaldol Products, Beta-Substituted Ketones, Isoxazolines, and Beta-Lactams Through Elaboration of Allylamine ...
Majority of those isolates had cross-resistance to the other allylamine, naftifine. A T1189C transition in the open reading ... The MICs and other salient features of azole- and/or allylamine-resistant isolates are provided in Table 2. ... Mutation in the Squalene Epoxidase Gene of Trichophyton interdigitale and Trichophyton rubrum Associated with Allylamine ... Mutation in the Squalene Epoxidase Gene of Trichophyton interdigitale and Trichophyton rubrum Associated with Allylamine ...
PALLADIUM-CATALYZED SYNTHESIS OF 2,3-DISUBSTITUTED ALLYLAMINES BY REGIOSELECTIVE AMINOPHENYLATION OR AMINOALKENYLATION OF 1,2- ...
Palladium-Catalyzed Vicinal Amino Alcohols Synthesis from Allyl Amines by In Situ Tether Formation and Carboetherification ... Home , Palladium-Catalyzed Vicinal Amino Alcohols Synthesis from Allyl Amines by In Situ Tether Formation and ...
... allylamine hydrochloride) (PAH). These include Wells-Dawson-derived sandwich-type Fe-4(III)(H2O)(2)(As2W15O56)(2)(12-)center ...
Optimizing the Mizoroki-Heck reaction of cyclic allyl amines: Gram-scale synthesis of preclamol without protecting groups. ... Optimizing the Mizoroki-Heck reaction of cyclic allyl amines: Gram-scale synthesis of preclamol... Sweeney, Joseph B.; Adams, ... Optimizing the Mizoroki-Heck reaction of cyclic allyl amines: Gram-scale synthesis of preclamol without protecting groups. ... lp/elsevier/optimizing-the-mizoroki-heck-reaction-of-cyclic-allyl-amines-gram-Dyb95BHqsw ...
Using plasma polymerised allylamine to culture hepatocytes in in-vitro fluidic bioreactor ... The main coating techniques employed were collagen in two forms, adsorbed and gel, and plasma polymerised allylamine (ppAAm).. ... Dehili, Chafika (2008) Using plasma polymerised allylamine to culture hepatocytes in in-vitro fluidic bioreactor. PhD thesis, ...
... allylamine hydrochloride) (PAH) doped inside CaCO(3) microparticles, followed by core removal. The PAH-Fc microcapsules had ... Nanotubes protruding from poly(allylamine hydrochloride)-graft-pyrene microcapsules.. *Zhipeng Wang, Helmuth Möhwald, Changyou ... Single-component microcapsules were fabricated by the in situ reaction of ferrocenecarboxaldehyde (Fc-CHO) with poly(allylamine ... Preparation and redox-controlled reversible response of ferrocene-modified poly(allylamine hydrochloride) microcapsules.. @ ...
The 8 hour LC50 of allylamine was 177 (151-209) ppm. Executive summary:. Mortality of male rats after 8 hours exposure to ... other: At all concentrations, allylamine was irritating to the eye and upper respiratory tract as indicated by face-washing ...
In this work, we report on the development of novel poly(allylamine) derivatives with different balance of the primary, ... Gene delivery efficiency and intracellular trafficking of novel poly(allylamine) derivatives. * Geyserite in hot-spring ... Gene delivery efficiency and intracellular trafficking of novel poly(allylamine) derivatives. International Journal of ...
We are Professional Manufacturer of Pharmaceutical Intermediates Material Allylamine company, Factory & Exporters specialize in ... Find Pharmaceutical Intermediates Material Allylamine Manufacturers & Suppliers from China. ... Pharmaceutical Intermediates Material Allylamine - manufacturer, factory, supplier from China. * * Organic Raw Material ... It appears to be a good value and I would recommend this Pharmaceutical Intermediates Material Allylamine . ...
"Allylamine" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... This graph shows the total number of publications written about "Allylamine" by people in this website by year, and whether " ... Below are the most recent publications written about "Allylamine" by people in Profiles. ...
Three groups of 10 male and 10 female rats received Allylamine by whole body inhalation at target exposure levels of 4, 7.5 or ... Three groups of 10 male and 10 female rats received Allylamine by whole body inhalation at target exposure levels of 4, 7.5 or ... The objective of this study was the assessment of Allylamine (a raw material in polymer manufacture) on the general systemic ... The objective of this study was the assessment of Allylamine (a raw material in polymer manufacture) on the general systemic ...
Allylamines[edit]. Allylamines[3] inhibit squalene epoxidase, another enzyme required for ergosterol synthesis. Examples ... Tolnaftate - a thiocarbamate antifungal, which inhibits fungal squalene epoxidase (similar mechanism to allylamines like ... "Research and Markets: Global Antifungal Therapeutics (Polyenes, Azoles, Echinocandins, Allylamines) Market:Trends and ...
E. Allylamine 1. Description. Allylamine is a colorless or yellowish volatile liquid with a very sharp ammonia-like odor that ... Allylamine cardiotoxicity is proposed to be related to its metabolism to acrolein and hydrogen peroxide. Allylamine acute ... Initial submission: Letter submitting enclosed information on exposure of workers to mono-allylamine, di-allylamine, and tri- ... Summary of Proposed AEGL Values for Allylamine [ppm (mg/m3)]. Classification. 10 mins.. 30 mins.. 1 hr.. 4 hrs.. 8 hrs.. ...
  • This new EU patent comprises composition of matter claims directed to novel topical formulations of antifungal allylamines (including terbinafine), as well as claims directed to methods of treatment of onychomycosis using these novel formulations, which enable enhanced penetration of antifungal allylamines into and through the nail. (thefreedictionary.com)
  • 2,12) Currently, there are 4 classes of antifungal agents with activity against Aspergillus: 1) the polyenes such as amphotericin B, 2) the triazoles, including itraconazole and voriconazole, 3) the echinocandins, such as caspofungin and micofungin, and 4) the allylamines , such as terbinafine. (thefreedictionary.com)
  • Terbinafine is an allylamine derivative that inhibits squalene epoxidase, a key enzyme in sterol biosynthesis in fungi. (medscape.com)
  • Terbinafine is an allylamine antifungal agent and acts by inhibiting squalene epoxidase, thus blocking the biosynthesis of ergosterol, an essential component of fungal cell membranes. (pharmacycode.com)
  • Panda, SS 2014, ' Stereoselective methodology for the synthesis of an antifungal allylamine: Terbinafine ', Letters in Organic Chemistry , vol. 11, no. 2, pp. 141-144. (elsevier.com)
  • Terbinafine hydrochloride is a synthetic allylamine antifungal. (sigmaaldrich.com)
  • Terbinafine hydrochloride is a synthetic allylamine derivative. (centerwatch.com)
  • Lamisil Tablets contain the synthetic allylamine antifungal compound terbinafine hydrochloride. (rxlist.com)
  • Terbinafine is an allylamine antifungal medication. (aocd.org)
  • All the agents--the azoles, allylamines , benzylamines, and ciclopirox--are going to work fairly well if you make a good choice for what you're trying to treat. (thefreedictionary.com)
  • The market is dominated by generics classes such as azoles, allylamines and benzylamines, which offer good safety and tolerability profiles, thereby creating strong competition among these products. (thefreedictionary.com)
  • com/research/c26efd/antifungals_market) has announced the addition of the "Antifungals Market to 2017 - Generic Erosion of Major Polyenes, Azoles, Allylamines and Echinocandins to Slow Value Growth" report to their offering. (thefreedictionary.com)
  • Though a significant progress has been made in the discovery of antifungal agents in the form of polyenes, azoles and allylamines yet the antifungal therapy poses severe challenge because of the side effects, narrow spectrum of activity and recently development resistance among patients against the present antifungals. (springer.com)
  • Here we report curcumin associated poly(allylamine hydrochloride) crosslinks with dipotassium phosphate and subsequently congregates with silica nanoparticles to form hierarchically ordered nanocapsule structures. (rsc.org)
  • Explicit- and implicit-solvent molecular dynamics simulations are performed to study complexation in two polyelectrolyte systems: poly(styrene sulfonate)/poly(allylamine hydrochloride) (PSS/PAH) and poly(acrylic acid)/poly(allylamine hydrochloride) (PAA/PAH). (aiche.org)
  • Poly(allylamine hydrochloride) hydrogels were cross-linked with glutaraldehyde to produce hydrogels with excellent expansion and contraction properties. (uib.no)
  • A series of transition metal substituted polyoxometalates (POMs) have been attached to carbon electrodes in multilayer films of poly(allylamine hydrochloride) (PAH). (kuleuven.be)
  • Preparation and redox-controlled reversible response of ferrocene-modified poly(allylamine hydrochloride) microcapsules. (semanticscholar.org)
  • article{Wang2011PreparationAR, title={Preparation and redox-controlled reversible response of ferrocene-modified poly(allylamine hydrochloride) microcapsules. (semanticscholar.org)
  • Single-component microcapsules were fabricated by the in situ reaction of ferrocenecarboxaldehyde (Fc-CHO) with poly(allylamine hydrochloride) (PAH) doped inside CaCO(3) microparticles, followed by core removal. (semanticscholar.org)
  • Nanotubes protruding from poly(allylamine hydrochloride)-graft-pyrene microcapsules. (semanticscholar.org)
  • In this work, we report on the development of novel poly(allylamine) derivatives with different balance of the primary, secondary, tertiary, and quaternary amino groups. (cnrs-orleans.fr)
  • The optimized structures by the PM3 and AM1 methods were compared with crystallographic data in order to analyze the reliability of the data and its use in the calculations of the structures of the compounds obtained from poly (allylamine) with Zn(II) acetate and Cu(II) acetate. (scielo.cl)
  • The aim of this paper is to report the synthesis of polymer-metal chelates of poly (allylamine) and Zn(II) acetate dihy drate and Cu(II) acetate monohydrate, and to study the influence of the polymeric ligand on the coordination type of the acetate groups. (scielo.cl)
  • This was done to analyze the certainty of the data obtained with these methods and then use them to calculate the structures of the compounds obtained from Zn(II) acetate dihydrate and Cu(II) acetate monohydrate with poly (allylamine). (scielo.cl)
  • Poly (allylamine) hydrochloride Mw = 60.000, Polysciences. (scielo.cl)
  • Poly(allylamine) solution average Mw ~15,000, 20 wt. (sigmaaldrich.com)
  • Allylamine antifungals are used to kill fungi to treat athlete's foot, jock itch, ringworm, and nail fungus. (goodrx.com)
  • Allylamines [3] inhibit squalene epoxidase , another enzyme required for ergosterol synthesis. (wikipedia.org)
  • Tinea corporis and cruris infections are usually treated for two weeks, while tinea pedis is treated for four weeks with an azole or for one to two weeks with allylamine medication. (aafp.org)
  • The allylamine derivatives, like the benzylamines, act at an earlier step in the ergosterol biosynthesis pathway than the azole class of antifungal drugs. (centerwatch.com)
  • Studies were conducted to evaluate the mechanisms involved in the deregulation of proliferative control induced by allylamine (AAM) in rat aortic smooth muscle cells (SMCs). (houstonmethodist.org)
  • Bowes, RC & Ramos, KS 1993, ' Allylamine enhances c-Ha-ras protooncogene expression in rat aortic smooth muscle cells ', Toxicology Letters , vol. 66, no. 3, pp. 263-272. (houstonmethodist.org)
  • We have developed a model of aortic smooth muscle necrosis in adult Sprague Dawley rats by feeding them two vascular toxins (allylamine HCl, or AA, and β-aminopropionitrile, or βAPN) in concert for 10 days. (utmb.edu)
  • Vascular (aortic) smooth muscle cells harvested from allylamine-treated animals (i.e., allylamine cells) acquire a proliferative advantage relative to control counterparts that is associated with differential secretion and extracellular matrix sequestration of several proteins. (houstonmethodist.org)
  • Additional layers may be applied, including amine-providing groups such as N-trimethylsilyl-allylamine, polyoxyalkylene tethers, and bioactive compounds. (google.co.uk)
  • A facile strategy to synthesis GO-ECH-DETA nanocomposite by the reaction of graphite oxide (GO) with epichlorohydrin (ECH) as a coupling agent and allylamine hydrochloride (AAH) as a cationic ligand (GO-ECH-AAH), were prepared and employed for endotoxin accumulation and removal from aqueous solution. (scitcentral.com)
  • Bacteriophage K has been successfully formulated with PNIPAM nanospheres copolymerized with allylamine (PNIPAM-co-ALA). By utilizing a temperature responsive polymer it has been possible to engineer the nanospheres to collapse at an elevated temperature associated with a bacterial skin infection. (bath.ac.uk)
  • The imprinted polymer prepared from allylamine had the highest affinity to the template, showing an imprinting factor of 3.43, and allylamine polymers MIP8/NIP8 were selected for further studies. (mdpi.com)
  • Allylamine polymer MIP8 had no affinity towards biogenic amines. (mdpi.com)
  • Exposure of Sprague-Dawley rats to Allylamine, using a snout-only inhalation exposure system, for 6 hours a day for 7 consecutive days at achieved aerosol concentrations of 11.9, 24.5 and 47.4 mg/m 3 was well tolerated and did not result in any histopathological changes. (europa.eu)
  • Urine samples from allylamine treated rats contained fairly constant amounts of OHPrMCA, 43.8 to 48.2 percent of the dose being excreted during the first 24 hours and 3 percent during the second 24 hour period. (cdc.gov)
  • Allylamines are a class of medication used in topical creams to cure ringworm. (emedicinehealth.com)
  • The macro pKa is the pH at which 50% of total 2-propen-1-amine is in the non-ionised form (Species 1), which is 9.70 for allylamine. (europa.eu)
  • All three allylamines, mono-, di-, and triallylamine, are produced by the treating allyl chloride with ammonia followed by distillation. (wikipedia.org)
  • Allylamine, like other allyl derivatives is a lachrymator and skin irritant. (wikipedia.org)
  • Hydrolysis of allyl isothiocyanate gives allylamine. (wikipedia.org)
  • Extensive contraction band necrosis and an apparently dose-dependent loss of CK were evident in allylamine-perfused hearts, whereas acrolein perfusion resulted in no morphologic lesions or CK loss. (utmb.edu)
  • In hemodynamic preparations of rat hearts perfused with 10 mm allylamine, contraction band necrosis and extensive mitochondrial changes were seen by electron microscopy. (utmb.edu)
  • The objective of this study was to unravel the mechanism(s) by which allylamine plasma polymers form. (open.ac.uk)
  • We assessed the in vitro toxicity of the cardiovascular toxicant allylamine, and its presumed in vivo metabolite, acrolein. (utmb.edu)
  • In dose-response experiments, rat hearts perfused with allylamine (10-30 mm) or acrolein (0.01-3.0 mm) for 2 hr were assessed by standard histopathology and assay of creatine kinase (CK) in effluent. (utmb.edu)
  • Allylamine-perfused hearts showed no grossly apparent functional abnormality except at 30 mm, but acrolein-perfused hearts beat irregularly and stopped rapidly (within 15 min at 0.01-0.3 mm, and by 5 min at 3.0 mm). (utmb.edu)
  • Parrish, AR & Ramos, KS 1997, ' Differential processing of osteopontin characterizes the proliferative vascular smooth muscle cell phenotype induced by allylamine ', Journal of Cellular Biochemistry , vol. 65, no. 2, pp. 267-275. (houstonmethodist.org)
  • The efforts described in this dissertation focus on the chemical model approach to investigate the mechanism of the monoamine oxidase (MAO) catalyzed oxidation of the cyclic tertiary allylamine 1-methyl-4-(2-methyl-1H-pyrrol-2-yl)-1,2,3,6-tetrahydropyridine (TMMP), which is a close analog of the parkinsonian-inducing designer drug 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). (vt.edu)
  • However, the cyclic tertiary allylamine TMMP has not been examined experimentally. (vt.edu)
  • In the plasma-gas phase, evidence is provided for reactions between cations and intact neutral monomers (allylamine). (open.ac.uk)
  • At all concentrations, allylamine was irritating to the eye and upper respiratory tract as indicated by face-washing motions. (europa.eu)
  • Slight reductions in bodyweight gain when compared with control were evident for males from all allylamine exposed groups. (europa.eu)
  • The radio-frequency-induced plasma polymerization of allylamine has been investigated in the plasma-gas phase by mass spectrometry and at the plasma-solid interface by means of an ion flux probe and a quartz mass balance. (open.ac.uk)
  • The main coating techniques employed were collagen in two forms, adsorbed and gel, and plasma polymerised allylamine (ppAAm). (nottingham.ac.uk)
  • Coronary flow was similar in control and allylamine-perfused hearts for 1 hr, but then declined slowly. (utmb.edu)
  • Repeated cycles of vascular injury by allylamine induce vascular lesions similar to those seen in atherosclerotic vessels, or following ballroon catheterization. (houstonmethodist.org)
  • Allylamine cells, however, produced increased amounts of a 36 kDa protein recognized by the OP-199 antibody. (houstonmethodist.org)
  • Pharmaceutically important allylamines include flunarizine and naftifine. (wikipedia.org)
  • Below are the most recent publications written about "Allylamine" by people in Profiles. (uchicago.edu)
  • OPN mRNA expression was enhanced during early G 1 cell cycle progression in allylamine cells relative to control counterparts. (houstonmethodist.org)
  • An antibody to the α(v) subunit, but not α 4 , nullified the proliferative advantage of allylamine cells relative to control counterparts, suggesting that integrinmediated signaling is a key feature of the proliferative phenotype of allylamine cells. (houstonmethodist.org)
  • Allylamine is an organic compound with the formula C3H5NH2. (wikipedia.org)
  • To determine if OPN and/or the 36 kDa fragment played a central role in the proliferative capacity of allylamine cells, the effect of an antibody to an α(v) integin subunit was examined. (houstonmethodist.org)
  • RT-PCR analysis demonstrated expression of a 1.2 kb OPN band in both cell types consistent with the predicted size of OPN mRNA, suggesting that the 36 kDa fragment recognized by OP-199 in allylamine cells was likely not due to altered splicing of the OPN transcript. (houstonmethodist.org)