Allylamine
Amines
Naphthalenes
Squalene Monooxygenase
The second enzyme in the committed pathway for CHOLESTEROL biosynthesis, this enzyme catalyzes the first oxygenation step in the biosynthesis of STEROLS and is thought to be a rate limiting enzyme in this pathway. Specifically, this enzyme catalyzes the conversion of SQUALENE to (S)-squalene-2,3-epoxide.
Ketoconazole
Indolequinones
Systematic review of topical treatments for fungal infections of the skin and nails of the feet. (1/66)
OBJECTIVE: To identify and synthesise the evidence for efficacy and cost effectiveness of topical treatments for superficial fungal infections of the skin and nails of the feet. DESIGN: Systematic review. INTERVENTIONS: Topical treatments for superficial fungal infections. MAIN OUTCOME MEASURES: Cure confirmed by culture and microscopy for skin and by culture for nails in patients with clinically diagnosed fungal infections. RESULTS: Of 126 trials identified in 121 papers, 72 (57.1%) met the inclusion criteria. Placebo controlled trials yielded pooled relative risks of failure to cure skin infections: allylamines (0.30, 95% confidence interval 0.24 to 0.38); azoles (0.54, 0.42 to 0.68); undecenoic acid (0.28, 0. 11 to 0.74); and tolnaftate (0.46, 0.17 to 1.22). Although meta-analysis of 11 trials comparing allylamines and azoles showed a relative risk of failure to cure of 0.88 (0.78 to 0.99) in favour of allylamines, there was evidence of language bias. Seven reports in English favoured allylamines (0.79, 0.69 to 0.91), but four reports in foreign languages showed no difference between the two drugs (1. 01, 0.90 to 1.13). Neither trial of nail infections showed significant differences between alternative topical treatments. CONCLUSIONS: Allylamines, azoles, and undecenoic acid were efficacious in placebo controlled trials. There are sufficient comparative trials to judge relative efficacy only between allylamines and azoles. Allylamines cure slightly more infections than azoles but are much more expensive than azoles. The most cost effective strategy is first to treat with azoles or undecenoic acid and to use allylamines only if that fails. (+info)Opposite effects of GABA(A) and GABA(C) receptor antagonists on the b-wave of ERG recorded from the isolated rat retina. (2/66)
The largest component in the fully dark-adapted ERG is a corneal-positive response, known as the b-wave, and believed to originate from depolarizing (ON-type) bipolar cells. The two types of GABA receptors, GABA(A) and GABA(C) have been reported to exist on bipolar cells in rat retina. The goal of these experiments was to find whether these GABA receptors participate in the generation of the b-wave of electroretinogram (ERG). ERGs were recorded from the isolated rat retinas. The P(2)(t) component, obtained by subtracting the ERGs measured before the application of 50 micrograms APB from those measured after the application of 50 micrograms APB, was used as an indicator of depolarizing bipolar cell activity. Photovoltages, the fast P(3)(t) component of ERG, were registered between the two microelectrodes across the rod outer segments. Bicuculline and 3-aminopropylphosphonic acid (3-APA) were used as selective antagonists of GABA(A) and GABA(C) receptors, respectively. It was found that the GABA(A) and GABA(C) receptors antagonists have opposite effects on the b-wave: bicuculline increased the b-wave amplitude, while 3-APA reduced the amplitude of the b-wave. Neither bicuculline nor 3-APA affect photoreceptors. (+info)New therapies on the horizon. (3/66)
Statins have proved to be potent drugs for reducing low-density lipoprotein cholesterol (LDL-C) levels. However, because the response to current statin therapy regimens is not always sufficient to reach defined goal levels, additional drugs to lower LDL-C are needed. New drugs may soon be available to lower LDL-C levels by mechanisms that differ from those of the statins. Among these new agents are a bile acid binding resin, inhibitors of bile acid transport, inhibitors of cholesterol transport, inhibitors of cholesterol esterification, and triglyceride-lowering agents. (+info)The development of an in-vitro perfusion system for studies on cultured cells. (4/66)
The design and use of a perfusion system, using a modified flow chamber for studies on cultured animal cells, is described. Rat thoracic aorta smooth muscle cells were isolated by an explant method and grown on Thermanox coverslips. These were introduced into the flow chamber. A flow rate of 25ml/min and a shear stress of 14.6 dynes/cm2 (12 dyne = 10 microN) (both within physiological limits) were maintained. Cells remained attached to the coverslips after 8h of perfusion with culture medium. The effect of exposing rat smooth muscle cells to the cardiovascular toxin, allylamine, is also described. The components of the system are routinely available, simple to clean, easy to assemble and sterilize. The incorporation of an in-line sensor that monitors pH, PO2, PCO2 and temperature ensures that the perfusion conditions remain within physiological limits. Automation means that minimal supervision is required. This system provides a potential mechanism in which cultured vascular cells may be perfused under controlled haemodynamic conditions, and their response to a cytotoxin may be evaluated. (+info)Overview of pharmacologic therapy for the treatment of dyslipidemia. (5/66)
Although the National Cholesterol Education Program Adult Treatment Panel III (ATP III) guidelines stress the importance of nonpharmacologic lipid modification interventions such as diet and exercise, the guidelines also recognize that many patients will require drug therapy to achieve low-density lipoprotein cholesterol (LDL-C) target goals. Currently available lipid-modifying drugs include bile acid sequestrants (or resins), fibrates, nicotinic acid, and statins, with each class exerting different effects on the lipid profile. In addition, nonprescription agents such as plant stanols and sterols have been shown to be effective in modifying plasma lipids. Of these agents, the statins are the most effective, most widely prescribed, and best-tolerated form of lipid-lowering drug therapy. New formulations of other drugs, such as niacin and bile acid sequestrants, can also improve treatment regimes and reduce side effects, thereby improving patient compliance with these therapies. In patients who have high levels of LDL-C and triglycerides together with low concentrations of high-density lipoprotein cholesterol (HDL-C), combination therapy may be required. Ezetimibe, a selective cholesterol absorption inhibitor, is the first of a new class of lipid-lowering agents and provides a new agent for the management of patients with dyslipidemia. Data from the ezetimibe clinical development program suggests that this agent can be used alone or in combination with statins to reduce LDL-C, improve compliance, and bring more patients to ATP III target goal. (+info)Regulation of alpha7-integrin expression in vascular smooth muscle by injury-induced atherosclerosis. (6/66)
Injury of vascular smooth muscle cells (VSMCs) by allylamine (AAM) leads to phenotypic changes associated with atherogenic progression including increased proliferation, migration, and alterations in cell adhesion. In the present study, the relationship between AAM-induced vascular injury and expression of the alpha(7)-integrin subunit was investigated. The alpha(7)-mRNA and protein expression were examined using real-time RT-PCR, fluorescence-activated cell sorting analysis (FACS), immunohistochemistry, and immunoblotting. In cultured VSMCs from aortas of AAM-treated rats (70 mg/kg for 20 days), alpha(7)-mRNA levels were increased more than twofold compared with control cells. No change was seen in beta(1)-integrin expression. FACS analysis revealed increased cell surface expression of alpha(7)-protein (25 +/- 9%; *P < 0.05). AAM treatment of naive VSMCs enhanced alpha(7)-mRNA expression (2.4 +/- 0.7-fold, mean +/- SE; *P < 0.05). The increased alpha(7)-mRNA expression was attenuated by the amine oxidase inhibitor semicarbazide and the antioxidant pyrrolidine dithiocarbamate, which confirms a role for oxidative stress in modulating alpha(7)-expression. In vivo alpha(7)-mRNA and protein expression were enhanced in the aortas of AAM-treated rats. In addition, increased alpha(7)-integrin expression facilitated AAM VSMC adhesion to laminin more efficiently compared with control (51 +/- 2%; *P < 0.05). Chemical injury induced by AAM significantly enhances alpha(7)-integrin expression in VSMCs. These findings implicate for the first time the expression of alpha(7)-integrin during the response of VSMCs to vascular injury. (+info)Ketogenic diet decreases circulating concentrations of neuroactive steroids of female rats. (7/66)
Ketogenic diet (KD) is used to manage intractable epilepsy; however, the mechanisms underlying its therapeutic effects are not known. Steroid hormones, such as progesterone and testosterone, are derived from cholesterol, and are readily 5alpha-reduced to dihydroprogesterone and dihydrotestosterone, which are subsequently converted to 5alpha-pregnan-3alpha-ol-20-one (3alpha,5alpha-THP) and 3alpha-androstanediol, neuroactive steroids that can influence seizures. The present study examined the effects of the KD on circulating concentrations of these neuroactive steroids, and their precursors, in intact female rats. Thirty-six, 22-day-old female Sprague-Dawley rats (weaned at 21 days) were fasted for 8 hours prior to placement on one of three dietary regimens for 6 weeks: ad libitum chow, calorie-restricted chow, or KD. After 6 weeks of the diet, when six rats in each dietary condition were in diestrus and six were in behavioral estrus, all rats were administered pentylenetetrazole (PTZ, 70 mg/kg, i.p.). The latency and incidence of seizures were recorded by an observer who was uninformed of the estrous cycle and dietary treatment conditions of the rats. Immediately after each test, trunk blood was obtained for later measurement of pregnane (progesterone, dihydroprogesterone, 3alpha,5alpha-THP) and androstane (testosterone, dihydrotestosterone, 3alpha-androstanediol) neuroactive steroid concentrations in plasma by radioimmunoassay. KD tended to lengthen the latency to, and significantly reduced the number of, PTZ-induced barrel roll seizures. KD also significantly reduced plasma levels of the pregnane (dihydroprogesterone, 3alpha,5alpha-THP) and androstane (dihydrotestosterone, 3alpha-androstanediol) 5alpha-reduced metabolites. These data suggest that levels of pregnane and androstane neuroactive steroids, or their precursors, may underlie some of the antiseizure effects of KD. (+info)Asymmetric synthesis of 4,5,6- and 3,4,5,6-substituted azepanes by a highly diastereoselective and enantioselective lithiation-conjugate addition sequence. (8/66)
Asymmetric syntheses of 4,5,6- and 3,4,5,6-substituted azepanes have been achieved by highly diastereoselective and enantioselective (-)-sparteine-mediated asymmetric lithiation-conjugate additions of N-Boc-N-(p-methoxyphenyl)-2,3-substituted allylamines to a beta-aryl alpha,beta-unsaturated ester followed by hydrolysis, cyclization, and reduction. Access to the enantiomeric adduct is provided by an invertive lithiation-stannylation-lithiation sequence. (+info)
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polypyrrole coated iron oxide nanoparticles modified with poly(allylamine hydrochloride)
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Allylamine
"Synthesis of allylamine in ethanol". ResearchGate. Retrieved 2020-06-30. M. T. Leffler (1938). "Allylamine". Organic Syntheses ... Functionalized allylamines have pharmaceutical applications. Pharmaceutically important allylamines include flunarizine and ... Allylamine, like other allyl derivatives is a lachrymator and skin irritant. Its oral LD50 is 106 mg/kg for rats. Nomenclature ... Allylamine is an organic compound with the formula C3H5NH2. This colorless liquid is the simplest stable unsaturated amine. All ...
Allyl isothiocyanate
Hydrolysis of allyl isothiocyanate gives allylamine. Allyl isothiocyanate has an LD50 of 151 mg/kg and is a lachrymator ( ... Leffler, M. T. (1938). "Allylamine". Organic Syntheses. 18: 5.; Collective Volume, vol. 2, p. 24 Zhang, Y (2010). "Allyl ...
Topical antifungal drugs
"Figure 1. Structures of antifungal allylamines". ResearchGate. Retrieved 2022-04-23. "Allylamine - an overview , ScienceDirect ... Mechanism of action Allylamines are a new type of antifungal drug that is highly selective for the fungal enzyme but has a ... Allylamines allow the active ingredients in the medication to accumulate well within the stratum corneum of the skin and nails ... Similar to azoles, allylamines disrupt the fungal cell wall synthesis through inhibition of the squalene epoxidase enzyme that ...
Triallylamine
Allylamines have particularly weak α-CH bonds, being near 80 kcal/mol. Allylamine Diallylamine "Triallylamine". pubchem.ncbi. ...
Diallylamine
Allylamine Triallylamine "Diallylamine". pubchem.ncbi.nlm.nih.gov. Retrieved 2 March 2022. Eller, Karsten; Henkes, Erhard; ...
Naftifine
... hydrochloride (brand names include Exoderil and Naftin) is an allylamine antifungal drug for the topical treatment of ... It was the first successful antifungal medication of the allylamine class. Naftifine has triple action: antifungal, ... Mühlbacher JM (1991). "Naftifine: a topical allylamine antifungal agent". Clinics in Dermatology. 9 (4): 479-85. doi:10.1016/ ...
Maleimide
Lin, K.-F.; Lin, J.-S.; Cheng, C.-H. (1996). "High temperature resins based on allylamine/bismaleimides". Polymer. 37 (21): ...
Polyallylamine hydrochloride
Poly(allylamine hydrochloride) has many biomedical applications. The most prominent use of this polyelectrolyte is in the field ... 71550-12-4) is a cationic polyelectrolyte prepared by the polymerization of allylamine. It can be used in combination with an ...
Polyelectrolyte
An LbL formation of PEM (PSS-PAH (poly(allylamine) hydrochloride)) on a gold substrate can be seen in the Figure. The formation ... "Metal Complexes of Amphoteric Cryogels Based on Allylamine and Methacrylic Acid". Macromolecular Symposia. 317-318: 18-27. doi: ...
Butenafine
Like the allylamine antifungals, butenafine works by inhibiting the synthesis of ergosterol by inhibiting squalene epoxidase, ... It is structurally related to synthetic allylamine antifungals such as terbinafine. Butenafine is indicated for the topical ...
Terbinafine
... is in the allylamines family of medications. It works by decreasing the ability of fungi to synthesize sterols. It ... Like other allylamines, terbinafine inhibits ergosterol synthesis by inhibiting squalene epoxidase, an enzyme that catalyzes ...
Hydroamination
Both systems produced the desired allyl amines in high yield, which contain an alkene that can be further functionalized ... The isolation and characterization of the rarer and more synthetically valuable kinetic allyl amine product was reported when ... Functionalized allylamines, which can be produced through hydroamination, have extensive pharmaceutical application, although ... Hydroamination has been utilized to synthesize the allylamine Cinnarizine in quantitative yield. Cinnarizine treats both ...
Aminoallyl nucleotide
Its formation can be associated with a reaction with an allylamine and various reagents via heck coupling are able to remove ... Aminoallyl nucleotide is a nucleotide with a modified base containing an allylamine. They are used in post-labeling of nucleic ... the halogen group from the base and add the allylamine to become the aminoallyl nucleoside shown on the right. The product on ...
Almitrine
Reaction with Allylamine [107-11-9] (4) completes the synthesis of Almitrine (5). Flunarizine Diphenylmethylpiperazine Servier ...
Kristy M. Ainslie
... allylamine) thin films". Langmuir. 23 (13): 7018-23. doi:10.1021/la7004997. PMID 17506587. Ainslie, Kristy; Sharma, Gurav; Dyer ...
Claisen rearrangement
Nubbemeyer, U. (1995). "1,2-Asymmetric Induction in the Zwitterionic Claisen Rearrangement of Allylamines". J. Org. Chem. 60 ( ...
Cyclopropene
CH2=CHCH2Cl + NaNH2 → C3H4 (cyclopropene) + NaCl + NH3 The major byproduct of the reaction is allylamine. Adding allyl chloride ...
Penicillium sclerotigenum
... allylamine hydrochloride) composite". Journal of Colloid and Interface Science. 396: 258-263. doi:10.1016/j.jcis.2013.01.023. ...
Tinea cruris
Studies suggest that allylamines (naftifine and terbinafine) are a quicker but more expensive form of treatment compared to ... Tinea cruris is treated by applying antifungal medications of the allylamine or azole type to the groin region. ...
Core-shell semiconductor nanocrystal
In particular, Si quantum dots with poly (acrylic acid) and allylamine shells have been used in cell labeling. Other in vitro ...
Petasis reaction
In comparison to other methods of generating allyl amines, the Petasis reaction tolerates a multifunctional scaffold, with a ... Vinyl boronic acids react with the adducts of secondary amines and paraformaldehyde to give tertiary allylamines. The geometry ... the corresponding allylamine is formed as a single diastereomer. Furthermore, enantiomeric purity can be achieved by ... A new method for the synthesis of geometrically pure allylamines". Tetrahedron Lett. 34 (4): 583-586. doi:10.1016/S0040-4039(00 ...
Borylation
... they have found that vinyl boronic acids can participate as nucleophiles to give geometrically pure allylamines. This modified ... A new method for the synthesis of geometrically pure allylamines". Tetrahedron Letters. 34 (4): 583-586. doi:10.1016/S0040-4039 ...
Trichophyton concentricum
... azole and allylamine agents have not been found to be as effective in treating tinea imbricata. However, griseofulvin has not ...
Trimethylsilyldiazomethane
The compound is a reagent in the Doyle-Kirmse reaction with allyl sulfides and allyl amines. Trimethylsilyldiazomethane is ...
Antifungal
"Research and Markets: Global Antifungal Therapeutics (Polyenes, Azoles, Echinocandins, Allylamines) Market:Trends and ... similar mechanism to allylamines like terbinafine)[medical citation needed] Triacetin - hydrolysed to acetic acid by fungal ... Fluconazole Isavuconazole Itraconazole Posaconazole Propiconazole Ravuconazole Terconazole Voriconazole Abafungin Allylamines ...
Athlete's foot
Allylamines such as terbinafine are considered more efficacious than azoles for the treatment of athlete's foot. Severe or ...
Fiona Meldrum
Allylamine Hydrochloride) and Magnesium Ions". Chemistry of Materials. 25 (24): 4994-5003. doi:10.1021/cm403497g. ISSN 0897- ...
Overman rearrangement
The resulting allylamine structures can be transformed into many chemically and biologically important natural and un-natural ...
Digambara Patra
... allyl amine) hydrochloride based nanocapsules: Piperine in nanocapsules accelerates encapsulation and release of curcumin and ...
Primary-amine oxidase
2008). "Anti-inflammatory effects of LJP 1586 [Z-3-fluoro-2-(4-methoxybenzyl)allylamine hydrochloride], an amine-based ...
Tinea Pedis Medication: Topical imidazoles, Topical pyridones, Topical allylamines, Topical benzylamines, Oral antimycotics,...
Topical allylamines. Class Summary. Topical allylamines are effective in treating all forms of tinea pedis. In vitro, these ... Topical benzylamines are sometimes classified as a subset of allylamines. They are useful for treating patients with refractory ... Naftifine is a broad-spectrum antifungal agent and synthetic allylamine derivative. Naftifine interferes with sterol ...
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Registration Dossier - ECHA
Although conducted using a method equivalent to OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test), no analytical monitoring of test concentrations was conducted and there are deficiencies in the reporting compared to requirements of the modern OECD 203 Guideline. However, for the purpose of assessment of aquatic toxicity, this study will be used in a weight-of-evidence approach in conjunction with data on fish, aquatic invertebrates and aquatic algae for the puspoe of PNEC determination ...
Synthetic sulfonated derivatives of poly(allylamine hydrochloride) as inhibitors of human metapneumovirus. | PLoS One;14(3):...
Synthetic sulfonated derivatives of poly(allylamine hydrochloride) as inhibitors of human Synthetic sulfonated derivatives of ... Previously, we reported that N-sulfonated derivatives of poly(allylamine hydrochloride) (NSPAHs) efficiently inhibit ... poly(allylamine hydrochloride) as inhibitors of human metapneumovirus. Ciejka, Justyna; Botwina, Pawel; Nowakowska, Maria; ...
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Adsorption of Anti-C-Reactive Protein Monoclonal Antibody and F(ab') Fragment on Plasma-Polymerized Styrene, Allylamine and...
Adsorption of Anti-C-Reactive Protein Monoclonal Antibody and F(ab) Fragment on Plasma-Polymerized Styrene, Allylamine and ... Adsorption of Anti-C-Reactive Protein Monoclonal Antibody and F(ab) Fragment on Plasma-Polymerized Styrene, Allylamine and ... Adsorption of Anti-C-Reactive Protein Monoclonal Antibody and F(ab) Fragment on Plasma-Polymerized Styrene, Allylamine and ... Adsorption of Anti-C-Reactive Protein Monoclonal Antibody and F(ab) Fragment on Plasma-Polymerized Styrene, Allylamine and ...
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van Os, M. T.; Menges, B.; Förch, R.; Knoll, W.; Timmons, R. B.; Vancso, G. J.: Thin film plasma deposition of allylamine; ... van Os, M. T.; Menges, B.; Foerch, R.; Vancso, G. J.; Knoll, W.: Characterization of Plasma-Polymerized Allylamine Using ... Variations in the Film Chemistry of Pulsed RF Plasma Deposited Allylamine. In: 13th International Symposium on Plasma Chemistry ...
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US Patent for Filter medium for selectively removing leucocytes Patent (Patent # 4,936,998 issued June 26, 1990) - Justia...
Examples of monomers containing nitrogen-containing basic functional groups include allylamine; (meth)acrylic acid derivatives ... having a nitrogen-containing basic functional group is selected from vinyl compounds of the group consisting of allylamine, ( ... having a nitrogen-containing basic functional group is selected from vinyl compounds of the group consisting of allylamine, ( ...
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The main types of drugs in antifungals are echinocandins, azoles, polyenes, and allylamines. Echinocandins are a new type of ... The global antifungals market is segmented - 1) By Drug Type: Echinocandins, Azoles, Polyenes, Allylamines 2) End users: ... Antifungals Global Market Report 2022 - By Drug Type (Echinocandins, Azoles, Polyenes, Allylamines), By End users (Hospitals & ... Antifungals Global Market Report 2022 - By Drug Type (Echinocandins, Azoles, Polyenes, Allylamines), By End users (Hospitals & ...
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Terbinafine4
- Terbinafine is an allylamine which has a broad spectrum of antifungal activity. (netmeds.com)
- The allylamine antifungal compound can be terbinafine or naftifine. (epo.org)
- Terbinafine is a member of the allylamine family, fungicidal agents that inhibit ergosterol synthesis by means of squalene epoxidase. (medscape.com)
- The allylamine terbinafine, which selectively inhibits squalene epoxidase Erg1 within the ergosterol biosynthetic pathway, is mainly used to treat dermatomycoses, whereas its effectiveness in other fungal infections is limited. (fecyt.es)
Poly4
- Molecular-level interactions are found to bind iron tetrasulfonated phthalocyanine (FeTsPc) and the polyelectrolyte poly(allylamine hydrochloride) (PAH) in electroactive layer-by-layer (LBL) films. (unesp.br)
- Synthetic sulfonated derivatives of poly(allylamine hydrochloride) as inhibitors of human metapneumovirus. (bvsalud.org)
- Previously, we reported that N-sulfonated derivatives of poly( allylamine hydrochloride) (NSPAHs) efficiently inhibit replication of the influenza virus in vitro and ex vivo. (bvsalud.org)
- Nanoporous thin films formed by salt-induced structural changes in multilayers of poly(acrylic acid) and poly(allylamine). (mpg.de)
Azoles1
- The 2 classes of antifungal medication most commonly used to treat tinea faciei in practice are azoles and allylamines. (medscape.com)
Topical1
- Treatments available with the indication of Malassezia overgrowth include both systemic treatment with azole derivatives or allylamine and a wide variety of agents for topical treatment. (slu.se)
Antifungal drugs1
- The drug is an outstanding representative of allylamine subgroup of antifungal drugs. (zenidol.at)
Synthetic1
- Naftin Cream is a synthetic allylamine derivative while Ketoconazole is an imidazole antifungal agent. (prescriptionpoint.com)
Benzylamines1
- Allylamines and benzylamines. (naftin.com)
Tinea1
- NAFTIN GEL 2% is an allylamine antifungal indicated for the treatment of interdigital tinea pedis caused by the organisms Trichophyton rubrum , Trichophyton mentagrophytes , and Epidermophyton floccosum in patients 12 years of age and older. (naftin.com)
Effective1
- The approach from the allylamine subgroup is effective against mold and yeast microorganisms. (zenidol.at)
Agents1
- 10 But NAFTIN GEL 2% is an allylamine, which means it is chemically distinct from azole-based antifungal agents. (naftin.com)
Poly18
- Poly (Allylamine Hydrochloride)" is the name of one of the most useful polymers. (chemistrylearner.com)
- However, the most important use of Poly (Allylamine Hydrochloride) is in Cell Encapsulation. (chemistrylearner.com)
- Poly(allylamine hydrochloride) was also grafted with phenyl azido groups and used as photoreactive polycations for LbL assembly. (phys.org)
- 6. Black phosphorus nanosheets/poly(allylamine hydrochloride) based electrochemical immunosensor for the selective detection of human epididymis protein 4. (nih.gov)
- Nanoporous thin films formed by salt-induced structural changes in multilayers of poly(acrylic acid) and poly(allylamine). (mpg.de)
- The effect of salt on the behaviour of bovine serum albumin (BSA) in solution and on the interactions between BSA and the weakly charged polyelectrolytes poly(allylamine hydrochloride) and poly(dimethylaminoethylmethacrylate) was investigated by potentiometric titrations. (srce.hr)
- The interaction of DNA with 5,10,15,20-tetrakis(4-N-methylpyridiniumyl)porphyrin (TMPyP) in polyelectrolyte core-shells obtained via layer by layer adsorption of poly(sodium 4-styrenesulfonate), PSS, and poly(allylamine hydrochloride), PAH, polyelectrolytes was followed by steady state, time resolved spectroscopy and by Fluorescence Lifetime Imaging Microscopy (FLIM). (jascoinc.com)
- An evanescent-wave optical fibre sensor modified with tetrakis(4-sulfophenyl)porphine (TSPP) and poly(allylamine hydrochloride) (PAH) bilayers using an layer-by-layer (LbL) approach was tested to measure the gas emitted from human skin. (spie.org)
- To address this problem, single-walled carbon nanotubes modified with poly (allylamine hydrochloride) (PAH/Ox-SWCNT) composite were synthesized and applied as an adsorbent for arsenic removal from aqueous solution in this study. (wwjournal.ir)
- The layer-by-layer method was used to coat 30mm of the central unclad section of a multimode polymeric optical fibre with 7 layers of a hydrophilic film consisting of bilayers of poly(allylamine hydrochloride) and SiO2 mesoporous nanoparticles. (nottingham.ac.uk)
- Modification with poly(acrylic acid) which has a similar structure to poly(acrylamide) also shows some enhancement in activity but is unstable, whereas poly(allylamine) completely suppresses CO2 reduction in favor of the hydrogen evolution reaction. (swan.ac.uk)
- Drastic enhancement of carbon dioxide adsorption in fluoroalkyl-modified poly(allylamine) by: Marco Taddei, et al. (swan.ac.uk)
- As cationic counterpart to form the anionic-cationic bilayer, different polyelectrolytes acting as the polymeric matrices embedding the sensing material have been studied: poly(diallyldimethylammonium chloride) (PDDA), polyethyleneimine (PEI) and poly(allylamine hydrochloride) (PAH). (uea.ac.uk)
- Sevelamer carbonate is known chemically as poly(allylamine-co-N,N'-diallyl-1,3 diamino-2-hydroxypropane) carbonate salt. (semperfidelishealthcare.com)
- We have fabricated polyelectrolyte multilayer films on gold, using poly(allylamine hydrochloride) (PAH) as the polycation and poly(acrylic acid) (PAA) as the polyanion. (elsevier.com)
- Poly(allylamine hydrochloride) was added to flip the surface charge of the particles from negative to positive as well as to serve as a stabilizing agent. (linfield.edu)
- Characterization data suggest that the particles are successfully coated with both poly(allylamine hydrochloride) and lipids and that monodispersity was maintained, as evidenced by the measured changes in size and optical properties. (linfield.edu)
- The large selection of basic polymers at Alfa Chemistry covers amine-functional polymers, such as allylamines, ethylenimines, oxazolines, as well as other amine polymers attached to the major or side chains, including poly(2-oxazoline), polyethyleneimine, and others. (rippeynews.org)
Terbinafine14
- Naftifine, the original member of the allylamine series, possesses only topical activity, whereas the naftifine analog terbinafine is active both topically and orally. (nih.gov)
- Effects of naftifine and terbinafine, two allylamine antifungal drugs, on selected functions of human polymorphonuclear leukocytes. (nih.gov)
- Terbinafine tablets are an allylamine antifungal indicated for the treatment of onychomycosis of the toenail or fingernail due to dermatophytes (tinea unguium). (nih.gov)
- LAMISIL® (terbinafine hydrochloride tablets) Tablets contain the synthetic allylamine antifungal compoundterbinafine hydrochloride. (druglib.com)
- Terbinafine is an allylamine that exhibits anticancer, antifungal, and anti-hyperlipidemic activities. (lktlabs.com)
- For the medical management of superficial and localized tinea corporis , topical azoles (eg, clotrimazole , ketoconazole ) and allylamines (eg, terbinafine , naftifine ) can be used to treat the affected area twice daily for 1-6 weeks on the basis of clinical response. (medscape.com)
- Terbinafine hydrochloride (Lamisil) is a synthetic allylamine antifungal. (herokuapp.com)
- Terbinafine/Lamisil is a synthetic allylamine derivative that inhibits squalene epoxidase, a key enzyme in sterol biosynthesis in fungi. (ubacare.com)
- Lamisil contains terbinafine, an allylamine which has a broad spectrum of antifungal activity. (dermatologyhandbook.co.uk)
- Terbinafine (Terbiface 500) 500 mg tablet is a synthetic allylamine antifungal used to treat various fungal infections of the fingernails, toenails and skin. (healingpharma.net)
- Terbinafine is an allylamine derivative that has a broad spectrum of antifungal activity against pathogens of the skin, hair, and nails. (healingpharma.net)
- Terbinafine is an Allylamine antifungal drug that produces its action by killing the fungi which are responsible for infections. (drugcarts.com)
- Terbinaforce Dusting Powder contains Terbinafine 1% w/w is an Allylamine antifungal drug that produces its action by inhibiting the growth of fungi by destroying the cell membrane this helps to treat skin infection. (drugcarts.com)
- Terbinafine is an allylamine antifungal indicated for the treatment of onychomycosis of the toenail or fingernail due to dermatophytes, ringworm infections (including tinea pedis, cruris and corporis) where oral therapy appropriate (due to site, severity or extent). (gafacom.website)
Synthetic3
- Allylamine derivatives: new class of synthetic antifungal agents inhibiting fungal squalene epoxidase. (nih.gov)
- Naftifine Hydrochloride is a synthetic allylamine derivative. (nih.gov)
- To study the complex interaction between oxidative injury and the pathogenesis of vascular disease, vascular gene expression was examined in male Sprague-Dawley rats given 35 or 70:mg/kg allylamine, a synthetic amine converted to acrolein and hydrogen peroxide within the vascular wall. (houstonmethodist.org)
Antifungal Agents1
- Clinical cure of an uncomplicated tinea cruris infection usually can be achieved using topical antifungal agents of the imidazole or allylamine family. (medscape.com)
Polymers2
- Homopolymers and Co-polymers can be prepared by Polymerization of Allylamine. (chemistrylearner.com)
- A new strategy to modulate the electrocatalytic activity of copper towards CO2 reduction involving adsorption of acrylamide, acrylic acid and allylamine polymers is presented. (swan.ac.uk)
Vascular smooth muscl1
- Williams, ES, Wilson, E & Ramos, KS 2012, ' NF-κB and matrix-dependent regulation of osteopontin promoter activity in allylamine-activated vascular smooth muscle cells ', Oxidative Medicine and Cellular Longevity . (elsevier.com)
Plasma-polymerized1
- The surfaces of plasma-polymerized (pp-) films from styrene, allylamine and acrylic acid were characterized by means of contact angle measurement. (elsevier.com)
Acrylic acid3
- Styrene, allylamine and acrylic acid were polymerized by plasma polymerization technique under the ninth polymerization condition from 100 W and 50 Pa to 200 W and 150 Pa. (elsevier.com)
- The values of contact angle of pp-styrene, pp-allylamine and pp-acrylic acid were widely scattered under the initial stage of nine polymerization conditions. (elsevier.com)
- However, these values after 40 days storage under vacuum condition always converged into 87° for pp-styrene, 67° for pp-allylamine and 28° for pp-acrylic acid, respectively. (elsevier.com)
Squalene1
- The allylamines are a new class of antifungal drugs that inhibit ergosterol synthesis at the level of squalene epoxidase. (nih.gov)
Antimycotics1
- Enantiomer with the allylamine antimycotics. (themauimiracle.org)
Toxin2
Vivo1
- Repeated cycles of oxidative injury by allylamine in vivo induce a proliferative rat vascular (aortic) smooth muscle cell (vSMC) phenotype characterized by matrix-dependent enhancement of mitogenic sensitivity, changes in cell surface integrin expression, and osteopontin (opn) overexpression. (elsevier.com)
Vitro1
- This in vitro profile is reflected by the clinical effectiveness of this allylamine in the treatment of dermatophyte infections. (nih.gov)
Rats1
- Urine samples from allylamine treated rats contained fairly constant amounts of OHPrMCA, 43.8 to 48.2 percent of the dose being excreted during the first 24 hours and 3 percent during the second 24 hour period. (cdc.gov)
Aortic1
- To evaluate mechanisms of gene dysregulation, cultured aortic smooth muscle cells were challenged with allylamine or its metabolites and processed for molecular analysis. (houstonmethodist.org)
Glutathione1
- Vascular lesions and extensive vascular remodeling, coupled to increased production of 8-epi-PGF2α, nuclear localization of NFκB, and alterations in glutathione homeostasis, were observed in animals treated with allylamine for up to 20:days. (houstonmethodist.org)
Treatment1
- Allylamine is used as antifungal medicine for the treatment of skin and scull ringworm. (chemistrylearner.com)
Protein1
- Matrix-specific changes in cellular Rel protein expression were observed in allylamine vSMCs. (elsevier.com)
Activity3
- Here, we show that constitutive and mitogen-stimulated NF-κB DNA binding activity is enhanced in allylamine vSMCs. (elsevier.com)
- The NF-κB DNA binding element located at -1943 in the 5()-UTR strongly inhibited opn promoter activity in allylamine vSMCs, and this response was regulated by the extracellular matrix. (elsevier.com)
- Constitutive increases in opn promoter activity were only seen when allylamine cells were seeded on a fibronectin substrate, and this response was independent of the NF-B DNA binding sequence within the regulatory region. (elsevier.com)
PRODUCTS1
- IP, network article, les products devices site nuestras bonds 8-bromo-9-butenylpurines attention tips techniques, la value et allylamine de sure profile et la de propulsion approach. (tonkel.de)
Water1
- Allylamine has high solubility in water. (chemistrylearner.com)