Possesses an unusual and selective cytotoxicity for VASCULAR SMOOTH MUSCLE cells in dogs and rats. Useful for experiments dealing with arterial injury, myocardial fibrosis or cardiac decompensation.
A group of compounds derived from ammonia by substituting organic radicals for the hydrogens. (From Grant & Hackh's Chemical Dictionary, 5th ed)
Two-ring crystalline hydrocarbons isolated from coal tar. They are used as intermediates in chemical synthesis, as insect repellents, fungicides, lubricants, preservatives, and, formerly, as topical antiseptics.
The second enzyme in the committed pathway for CHOLESTEROL biosynthesis, this enzyme catalyzes the first oxygenation step in the biosynthesis of STEROLS and is thought to be a rate limiting enzyme in this pathway. Specifically, this enzyme catalyzes the conversion of SQUALENE to (S)-squalene-2,3-epoxide.
Broad spectrum antifungal agent used for long periods at high doses, especially in immunosuppressed patients.
INDOLES which have two keto groups forming QUINONES like structures of the indole aromatic ring.
Polyamines are organic compounds with more than one amino group, involved in various biological processes such as cell growth, differentiation, and apoptosis, and found to be increased in certain diseases including cancer.

Systematic review of topical treatments for fungal infections of the skin and nails of the feet. (1/66)

OBJECTIVE: To identify and synthesise the evidence for efficacy and cost effectiveness of topical treatments for superficial fungal infections of the skin and nails of the feet. DESIGN: Systematic review. INTERVENTIONS: Topical treatments for superficial fungal infections. MAIN OUTCOME MEASURES: Cure confirmed by culture and microscopy for skin and by culture for nails in patients with clinically diagnosed fungal infections. RESULTS: Of 126 trials identified in 121 papers, 72 (57.1%) met the inclusion criteria. Placebo controlled trials yielded pooled relative risks of failure to cure skin infections: allylamines (0.30, 95% confidence interval 0.24 to 0.38); azoles (0.54, 0.42 to 0.68); undecenoic acid (0.28, 0. 11 to 0.74); and tolnaftate (0.46, 0.17 to 1.22). Although meta-analysis of 11 trials comparing allylamines and azoles showed a relative risk of failure to cure of 0.88 (0.78 to 0.99) in favour of allylamines, there was evidence of language bias. Seven reports in English favoured allylamines (0.79, 0.69 to 0.91), but four reports in foreign languages showed no difference between the two drugs (1. 01, 0.90 to 1.13). Neither trial of nail infections showed significant differences between alternative topical treatments. CONCLUSIONS: Allylamines, azoles, and undecenoic acid were efficacious in placebo controlled trials. There are sufficient comparative trials to judge relative efficacy only between allylamines and azoles. Allylamines cure slightly more infections than azoles but are much more expensive than azoles. The most cost effective strategy is first to treat with azoles or undecenoic acid and to use allylamines only if that fails.  (+info)

Opposite effects of GABA(A) and GABA(C) receptor antagonists on the b-wave of ERG recorded from the isolated rat retina. (2/66)

The largest component in the fully dark-adapted ERG is a corneal-positive response, known as the b-wave, and believed to originate from depolarizing (ON-type) bipolar cells. The two types of GABA receptors, GABA(A) and GABA(C) have been reported to exist on bipolar cells in rat retina. The goal of these experiments was to find whether these GABA receptors participate in the generation of the b-wave of electroretinogram (ERG). ERGs were recorded from the isolated rat retinas. The P(2)(t) component, obtained by subtracting the ERGs measured before the application of 50 micrograms APB from those measured after the application of 50 micrograms APB, was used as an indicator of depolarizing bipolar cell activity. Photovoltages, the fast P(3)(t) component of ERG, were registered between the two microelectrodes across the rod outer segments. Bicuculline and 3-aminopropylphosphonic acid (3-APA) were used as selective antagonists of GABA(A) and GABA(C) receptors, respectively. It was found that the GABA(A) and GABA(C) receptors antagonists have opposite effects on the b-wave: bicuculline increased the b-wave amplitude, while 3-APA reduced the amplitude of the b-wave. Neither bicuculline nor 3-APA affect photoreceptors.  (+info)

New therapies on the horizon. (3/66)

Statins have proved to be potent drugs for reducing low-density lipoprotein cholesterol (LDL-C) levels. However, because the response to current statin therapy regimens is not always sufficient to reach defined goal levels, additional drugs to lower LDL-C are needed. New drugs may soon be available to lower LDL-C levels by mechanisms that differ from those of the statins. Among these new agents are a bile acid binding resin, inhibitors of bile acid transport, inhibitors of cholesterol transport, inhibitors of cholesterol esterification, and triglyceride-lowering agents.  (+info)

The development of an in-vitro perfusion system for studies on cultured cells. (4/66)

The design and use of a perfusion system, using a modified flow chamber for studies on cultured animal cells, is described. Rat thoracic aorta smooth muscle cells were isolated by an explant method and grown on Thermanox coverslips. These were introduced into the flow chamber. A flow rate of 25ml/min and a shear stress of 14.6 dynes/cm2 (12 dyne = 10 microN) (both within physiological limits) were maintained. Cells remained attached to the coverslips after 8h of perfusion with culture medium. The effect of exposing rat smooth muscle cells to the cardiovascular toxin, allylamine, is also described. The components of the system are routinely available, simple to clean, easy to assemble and sterilize. The incorporation of an in-line sensor that monitors pH, PO2, PCO2 and temperature ensures that the perfusion conditions remain within physiological limits. Automation means that minimal supervision is required. This system provides a potential mechanism in which cultured vascular cells may be perfused under controlled haemodynamic conditions, and their response to a cytotoxin may be evaluated.  (+info)

Overview of pharmacologic therapy for the treatment of dyslipidemia. (5/66)

Although the National Cholesterol Education Program Adult Treatment Panel III (ATP III) guidelines stress the importance of nonpharmacologic lipid modification interventions such as diet and exercise, the guidelines also recognize that many patients will require drug therapy to achieve low-density lipoprotein cholesterol (LDL-C) target goals. Currently available lipid-modifying drugs include bile acid sequestrants (or resins), fibrates, nicotinic acid, and statins, with each class exerting different effects on the lipid profile. In addition, nonprescription agents such as plant stanols and sterols have been shown to be effective in modifying plasma lipids. Of these agents, the statins are the most effective, most widely prescribed, and best-tolerated form of lipid-lowering drug therapy. New formulations of other drugs, such as niacin and bile acid sequestrants, can also improve treatment regimes and reduce side effects, thereby improving patient compliance with these therapies. In patients who have high levels of LDL-C and triglycerides together with low concentrations of high-density lipoprotein cholesterol (HDL-C), combination therapy may be required. Ezetimibe, a selective cholesterol absorption inhibitor, is the first of a new class of lipid-lowering agents and provides a new agent for the management of patients with dyslipidemia. Data from the ezetimibe clinical development program suggests that this agent can be used alone or in combination with statins to reduce LDL-C, improve compliance, and bring more patients to ATP III target goal.  (+info)

Regulation of alpha7-integrin expression in vascular smooth muscle by injury-induced atherosclerosis. (6/66)

Injury of vascular smooth muscle cells (VSMCs) by allylamine (AAM) leads to phenotypic changes associated with atherogenic progression including increased proliferation, migration, and alterations in cell adhesion. In the present study, the relationship between AAM-induced vascular injury and expression of the alpha(7)-integrin subunit was investigated. The alpha(7)-mRNA and protein expression were examined using real-time RT-PCR, fluorescence-activated cell sorting analysis (FACS), immunohistochemistry, and immunoblotting. In cultured VSMCs from aortas of AAM-treated rats (70 mg/kg for 20 days), alpha(7)-mRNA levels were increased more than twofold compared with control cells. No change was seen in beta(1)-integrin expression. FACS analysis revealed increased cell surface expression of alpha(7)-protein (25 +/- 9%; *P < 0.05). AAM treatment of naive VSMCs enhanced alpha(7)-mRNA expression (2.4 +/- 0.7-fold, mean +/- SE; *P < 0.05). The increased alpha(7)-mRNA expression was attenuated by the amine oxidase inhibitor semicarbazide and the antioxidant pyrrolidine dithiocarbamate, which confirms a role for oxidative stress in modulating alpha(7)-expression. In vivo alpha(7)-mRNA and protein expression were enhanced in the aortas of AAM-treated rats. In addition, increased alpha(7)-integrin expression facilitated AAM VSMC adhesion to laminin more efficiently compared with control (51 +/- 2%; *P < 0.05). Chemical injury induced by AAM significantly enhances alpha(7)-integrin expression in VSMCs. These findings implicate for the first time the expression of alpha(7)-integrin during the response of VSMCs to vascular injury.  (+info)

Ketogenic diet decreases circulating concentrations of neuroactive steroids of female rats. (7/66)

Ketogenic diet (KD) is used to manage intractable epilepsy; however, the mechanisms underlying its therapeutic effects are not known. Steroid hormones, such as progesterone and testosterone, are derived from cholesterol, and are readily 5alpha-reduced to dihydroprogesterone and dihydrotestosterone, which are subsequently converted to 5alpha-pregnan-3alpha-ol-20-one (3alpha,5alpha-THP) and 3alpha-androstanediol, neuroactive steroids that can influence seizures. The present study examined the effects of the KD on circulating concentrations of these neuroactive steroids, and their precursors, in intact female rats. Thirty-six, 22-day-old female Sprague-Dawley rats (weaned at 21 days) were fasted for 8 hours prior to placement on one of three dietary regimens for 6 weeks: ad libitum chow, calorie-restricted chow, or KD. After 6 weeks of the diet, when six rats in each dietary condition were in diestrus and six were in behavioral estrus, all rats were administered pentylenetetrazole (PTZ, 70 mg/kg, i.p.). The latency and incidence of seizures were recorded by an observer who was uninformed of the estrous cycle and dietary treatment conditions of the rats. Immediately after each test, trunk blood was obtained for later measurement of pregnane (progesterone, dihydroprogesterone, 3alpha,5alpha-THP) and androstane (testosterone, dihydrotestosterone, 3alpha-androstanediol) neuroactive steroid concentrations in plasma by radioimmunoassay. KD tended to lengthen the latency to, and significantly reduced the number of, PTZ-induced barrel roll seizures. KD also significantly reduced plasma levels of the pregnane (dihydroprogesterone, 3alpha,5alpha-THP) and androstane (dihydrotestosterone, 3alpha-androstanediol) 5alpha-reduced metabolites. These data suggest that levels of pregnane and androstane neuroactive steroids, or their precursors, may underlie some of the antiseizure effects of KD.  (+info)

Asymmetric synthesis of 4,5,6- and 3,4,5,6-substituted azepanes by a highly diastereoselective and enantioselective lithiation-conjugate addition sequence. (8/66)

Asymmetric syntheses of 4,5,6- and 3,4,5,6-substituted azepanes have been achieved by highly diastereoselective and enantioselective (-)-sparteine-mediated asymmetric lithiation-conjugate additions of N-Boc-N-(p-methoxyphenyl)-2,3-substituted allylamines to a beta-aryl alpha,beta-unsaturated ester followed by hydrolysis, cyclization, and reduction. Access to the enantiomeric adduct is provided by an invertive lithiation-stannylation-lithiation sequence.  (+info)

Allylamine is an organic compound with the formula CH2=CH-CH2-NH2. It is a colorless liquid that is soluble in water and polar organic solvents. Allylamine is used as a building block in the synthesis of various chemical compounds, including pharmaceuticals, agrochemicals, and polymers.

In the medical field, allylamine derivatives are used as antifungal agents. These drugs work by inhibiting the enzyme squalene epoxidase, which is necessary for the synthesis of ergosterol, a key component of fungal cell membranes. By blocking the production of ergosterol, allylamine derivatives disrupt the integrity of fungal cell membranes and prevent the growth of fungi. Examples of allylamine antifungal drugs include terbinafine and naftifine.

Amines are organic compounds that contain a basic nitrogen atom with a lone pair of electrons. They are derived from ammonia (NH3) by replacing one or more hydrogen atoms with alkyl or aryl groups. The nomenclature of amines follows the substitutive type, where the parent compound is named as an aliphatic or aromatic hydrocarbon, and the functional group "amine" is designated as a suffix or prefix.

Amines are classified into three types based on the number of carbon atoms attached to the nitrogen atom:

1. Primary (1°) amines: One alkyl or aryl group is attached to the nitrogen atom.
2. Secondary (2°) amines: Two alkyl or aryl groups are attached to the nitrogen atom.
3. Tertiary (3°) amines: Three alkyl or aryl groups are attached to the nitrogen atom.

Quaternary ammonium salts have four organic groups attached to the nitrogen atom and a positive charge, with anions balancing the charge.

Amines have a wide range of applications in the chemical industry, including pharmaceuticals, dyes, polymers, and solvents. They also play a significant role in biological systems as neurotransmitters, hormones, and cell membrane components.

Naphthalene is not typically referred to as a medical term, but it is a chemical compound with the formula C10H8. It is a white crystalline solid that is aromatic and volatile, and it is known for its distinctive mothball smell. In a medical context, naphthalene is primarily relevant as a potential toxin or irritant.

Naphthalene can be found in some chemical products, such as mothballs and toilet deodorant blocks. Exposure to high levels of naphthalene can cause symptoms such as nausea, vomiting, diarrhea, and headaches. Long-term exposure has been linked to anemia and damage to the liver and nervous system.

In addition, naphthalene is a known environmental pollutant that can be found in air, water, and soil. It is produced by the combustion of fossil fuels and is also released from some industrial processes. Naphthalene has been shown to have toxic effects on aquatic life and may pose a risk to human health if exposure levels are high enough.

Squalene monooxygenase is an enzyme involved in the biosynthesis of cholesterol and other sterols. This enzyme catalyzes the conversion of squalene to squalene 2,3-epoxide, which is a key step in the biosynthetic pathway leading to the formation of cholesterol. The reaction catalyzed by squalene monooxygenase involves the incorporation of molecular oxygen and the reduction of NADPH to NADP+.

The gene that encodes squalene monooxygenase is called SQLE, which is located on human chromosome 8 (8p21.3). Mutations in this gene have been associated with several genetic disorders, including Smith-Lemli-Opitz syndrome and desmosterolosis, which are characterized by abnormal cholesterol metabolism.

Squalene monooxygenase is an important enzyme in the regulation of cholesterol biosynthesis, and its activity is regulated by several factors, including sterol regulatory element-binding proteins (SREBPs) and insulin-induced gene 1 (INSIG1). Inhibition of squalene monooxygenase has been explored as a potential therapeutic strategy for the treatment of hypercholesterolemia and related cardiovascular diseases.

Ketoconazole is an antifungal medication that is primarily used to treat various fungal infections, including those caused by dermatophytes, Candida, and pityrosporum. It works by inhibiting the synthesis of ergosterol, a crucial component of fungal cell membranes, which leads to increased permeability and ultimately results in fungal cell death.

Ketoconazole is available as an oral tablet for systemic use and as a topical cream or shampoo for localized applications. The oral formulation is used to treat severe or invasive fungal infections, while the topical preparations are primarily indicated for skin and scalp infections, such as athlete's foot, ringworm, jock itch, candidiasis, and seborrheic dermatitis.

Common side effects of oral ketoconazole include nausea, vomiting, headache, and altered liver function tests. Rare but serious adverse reactions may include hepatotoxicity, adrenal insufficiency, and interactions with other medications that can affect the metabolism and elimination of drugs. Topical ketoconazole is generally well-tolerated, with local irritation being the most common side effect.

It's important to note that due to its potential for serious liver toxicity and drug-drug interactions, oral ketoconazole has been largely replaced by other antifungal agents, such as fluconazole and itraconazole, which have more favorable safety profiles. Topical ketoconazole remains a valuable option for treating localized fungal infections due to its effectiveness and lower risk of systemic side effects.

Indolequinones are a type of chemical compound that consist of an indole ring, which is a heterocyclic aromatic organic compound, fused to a quinone ring. They can be found in some natural sources, including certain types of bacteria and fungi, as well as in synthetic forms.

Indolequinones have been studied for their potential use in medical treatments, particularly in the area of cancer research. Some indolequinones have been shown to have antitumor properties and are being investigated as possible chemotherapeutic agents. However, they can also be toxic and may have side effects, so further research is needed to determine their safety and effectiveness for medical use.

Polyamines are organic compounds with more than one amino group (-NH2) and at least one carbon atom bonded to two or more amino groups. They are found in various tissues and fluids of living organisms and play important roles in many biological processes, such as cell growth, differentiation, and apoptosis (programmed cell death). Polyamines are also involved in the regulation of ion channels and transporters, DNA replication and gene expression. The most common polyamines found in mammalian cells are putrescine, spermidine, and spermine. They are derived from the decarboxylation of amino acids such as ornithine and methionine. Abnormal levels of polyamines have been associated with various pathological conditions, including cancer and neurodegenerative diseases.

"Synthesis of allylamine in ethanol". ResearchGate. Retrieved 2020-06-30. M. T. Leffler (1938). "Allylamine". Organic Syntheses ... Functionalized allylamines have pharmaceutical applications. Pharmaceutically important allylamines include flunarizine and ... Allylamine, like other allyl derivatives is a lachrymator and skin irritant. Its oral LD50 is 106 mg/kg for rats. Nomenclature ... Allylamine is an organic compound with the formula C3H5NH2. This colorless liquid is the simplest stable unsaturated amine. All ...
Hydrolysis of allyl isothiocyanate gives allylamine. Allyl isothiocyanate has an LD50 of 151 mg/kg and is a lachrymator ( ... Leffler, M. T. (1938). "Allylamine". Organic Syntheses. 18: 5.; Collective Volume, vol. 2, p. 24 Zhang, Y (2010). "Allyl ...
Allylamines have particularly weak α-CH bonds, being near 80 kcal/mol. Allylamine Diallylamine "Triallylamine". pubchem.ncbi. ...
Allylamine Triallylamine "Diallylamine". pubchem.ncbi.nlm.nih.gov. Retrieved 2 March 2022. Eller, Karsten; Henkes, Erhard; ...
... hydrochloride (brand names include Exoderil and Naftin) is an allylamine antifungal drug for the topical treatment of ... It was the first successful antifungal medication of the allylamine class. Naftifine has triple action: antifungal, ... Mühlbacher JM (1991). "Naftifine: a topical allylamine antifungal agent". Clinics in Dermatology. 9 (4): 479-85. doi:10.1016/ ...
Poly(allylamine hydrochloride) has many biomedical applications. The most prominent use of this polyelectrolyte is in the field ... 71550-12-4) is a cationic polyelectrolyte prepared by the polymerization of allylamine. It can be used in combination with an ...
An LbL formation of PEM (PSS-PAH (poly(allylamine) hydrochloride)) on a gold substrate can be seen in the Figure. The formation ... "Metal Complexes of Amphoteric Cryogels Based on Allylamine and Methacrylic Acid". Macromolecular Symposia. 317-318: 18-27. doi: ...
... is in the allylamines family of medications. It works by decreasing the ability of fungi to synthesize sterols. It ... Like other allylamines, terbinafine inhibits ergosterol synthesis by inhibiting squalene epoxidase, an enzyme that catalyzes ...
Both systems produced the desired allyl amines in high yield, which contain an alkene that can be further functionalized ... The isolation and characterization of the rarer and more synthetically valuable kinetic allyl amine product was reported when ... Functionalized allylamines, which can be produced through hydroamination, have extensive pharmaceutical application, although ... Hydroamination has been utilized to synthesize the allylamine Cinnarizine in quantitative yield. Cinnarizine treats both ...
Its formation can be associated with a reaction with an allylamine and various reagents via heck coupling are able to remove ... Aminoallyl nucleotide is a nucleotide with a modified base containing an allylamine. They are used in post-labeling of nucleic ... the halogen group from the base and add the allylamine to become the aminoallyl nucleoside shown on the right. The product on ...
... allylamine) thin films". Langmuir. 23 (13): 7018-23. doi:10.1021/la7004997. PMID 17506587. Ainslie, Kristy; Sharma, Gurav; Dyer ...
Nubbemeyer, U. (1995). "1,2-Asymmetric Induction in the Zwitterionic Claisen Rearrangement of Allylamines". J. Org. Chem. 60 ( ...
Studies suggest that allylamines (naftifine and terbinafine) are a quicker but more expensive form of treatment compared to ... Tinea cruris is treated by applying antifungal medications of the allylamine or azole type to the groin region. ...
In particular, Si quantum dots with poly (acrylic acid) and allylamine shells have been used in cell labeling. Other in vitro ...
In comparison to other methods of generating allyl amines, the Petasis reaction tolerates a multifunctional scaffold, with a ... Vinyl boronic acids react with the adducts of secondary amines and paraformaldehyde to give tertiary allylamines. The geometry ... the corresponding allylamine is formed as a single diastereomer. Furthermore, enantiomeric purity can be achieved by ... A new method for the synthesis of geometrically pure allylamines". Tetrahedron Lett. 34 (4): 583-586. doi:10.1016/S0040-4039(00 ...
... they have found that vinyl boronic acids can participate as nucleophiles to give geometrically pure allylamines. This modified ... A new method for the synthesis of geometrically pure allylamines". Tetrahedron Letters. 34 (4): 583-586. doi:10.1016/S0040-4039 ...
... azole and allylamine agents have not been found to be as effective in treating tinea imbricata. However, griseofulvin has not ...
The compound is a reagent in the Doyle-Kirmse reaction with allyl sulfides and allyl amines. Trimethylsilyldiazomethane is ...
Allylamines such as terbinafine are considered more efficacious than azoles for the treatment of athlete's foot. Severe or ... In the 1990's research supported the use of itraconazole and the Allylamine known as terbinafine as drugs effective at ...
The resulting allylamine structures can be transformed into many chemically and biologically important natural and un-natural ...
... allyl amine) hydrochloride based nanocapsules: Piperine in nanocapsules accelerates encapsulation and release of curcumin and ...
2008). "Anti-inflammatory effects of LJP 1586 [Z-3-fluoro-2-(4-methoxybenzyl)allylamine hydrochloride], an amine-based ...
... and allylamines (e.g., terbinafine). Undecylenic acid is also a precursor to antidandruff shampoos and antimicrobial powders. ...
... the epoxide is opened with allyl amine to yield the corresponding 1,2-amino alcohol. The water-immiscible solvents methyl tert- ... results in an intermediate that was poised to undergo aziridination upon transimination with another equivalent of allylamine. ...
US granted 2561899, Donald Wallace Adamson, "Dithienyl Allyl Amines", issued 24 July 1951, assigned to Burroughs Wellcome Co ...
... allylamine which converts in 1-allylpiperidin-4-one by acid hydrolysis and decarboxylation. Then a Mannich reaction occurs, in ... particular a condensation of a 4-piperidone derivative with paraformaldehyde and allylamine in presence of acetic acid forms N, ...
The molecular formula C3H7N may refer to: Acetone imine Allylamine (2-propen-1-amine) Azetidine (trimethylenimine) ...
... allylamine MeSH D02.455.326.271.122.260 - allylglycine MeSH D02.455.326.271.122.272 - allylisopropylacetamide MeSH D02.455. ...
The major byproduct of the reaction is allylamine. Adding allyl chloride to sodium bis(trimethylsilyl)amide in boiling toluene ...
... the carbonylation of allylamine, the hydrogenation of succinonitrile under hydrolytic conditions and the reaction of maleic or ...
"Synthesis of allylamine in ethanol". ResearchGate. Retrieved 2020-06-30. M. T. Leffler (1938). "Allylamine". Organic Syntheses ... Functionalized allylamines have pharmaceutical applications. Pharmaceutically important allylamines include flunarizine and ... Allylamine, like other allyl derivatives is a lachrymator and skin irritant. Its oral LD50 is 106 mg/kg for rats. Nomenclature ... Allylamine is an organic compound with the formula C3H5NH2. This colorless liquid is the simplest stable unsaturated amine. All ...
Topical allylamines. Naftifine 1% cream or gel (Naftin). *View full drug information ... Terbinafine has fungicidal activity; it is a synthetic allylamine derivative that inhibits squalene epoxidase, a key enzyme in ... Terbinafine topical has fungicidal activity; it is a synthetic allylamine derivative that inhibits squalene epoxidase, a key ...
Poly(allylamine) magnetomicelles for image guided drug delivery. Christopher M. Barnett, Martin R. Lees, Anthony D.M. Curtis, ... Barnett, C. M., Lees, M. R., Curtis, A. D. M., Lin, P. K. T., Cheng, W. P., & Hoskins, C. (2013). Poly(allylamine) ... Poly(allylamine) magnetomicelles for image guided drug delivery. In: Pharmaceutical Nanotechnology. 2013 ; Vol. 1, No. 3. pp. ... Poly(allylamine) magnetomicelles for image guided drug delivery. / Barnett, Christopher M.; Lees, Martin R.; Curtis, Anthony D. ...
pulp and paper industry, mineral washing industry, textile printing and dyeing industry, fine chemicals, water treatment industry
Allylamines. Allylamines work by inhibiting an enzyme that the membrane of the cell requires to operate correctly. Without this ... An example of an allylamine is terbinafine, which treats fungal skin infections. ...
... allylamine)-g-poly(N-isopropylacrylamide) copolymers: Salt-tuned phase separation, particle formation and their applicability ... Thermosensitive poly(allylamine)-g-poly(N-isopropylacrylamide) copolymers: Salt-tuned phase separation, particle formation and ... Gao, C. Y., Chen, B., & Möhwald, H. (2006). Thermosensitive poly(allylamine)-g-poly(N-isopropylacrylamide) copolymers: Salt- ...
Allylamines:. Allylamines are antifungal drugs that work by inhibiting an enzyme called squalene epoxidase, which is essential ... Common examples of allylamines include terbinafine and naftifine.. Echinocandins:. Echinocandins are a relatively newer class ... Other types of drugs, such as polyenes and allylamines, work by disrupting the integrity of the fungal cell membrane. The ... Other types of drugs, such as polyenes and allylamines, disrupt the integrity of the fungal cell membrane. This classification ...
A multi-ion beam microanalysis approach for the characterization of plasma polymerized allylamine films. Apr 10, 2024 ... "A multi-ion beam microanalysis approach for the characterization of plasma polymerized allylamine films", The European Physical ... A multi-ion beam microanalysis approach for the characterization of plasma polymerized allylamine films}, volume = {56}, ...
27 Topical allylamines (e.g., terbinafine [Lamisil]) were better than azoles (e.g., ketoconazole) for sustained cures.28 Oral ...
Allylamines[edit]. Allylamines[12] inhibit squalene epoxidase, another enzyme required for ergosterol synthesis. Examples ... Tolnaftate - a thiocarbamate antifungal, which inhibits fungal squalene epoxidase (similar mechanism to allylamines like ... "Research and Markets: Global Antifungal Therapeutics (Polyenes, Azoles, Echinocandins, Allylamines) Market:Trends and ...
Although the allylamine terbinafine is not used for treatment of patients with invasive aspergillosis, the drug is highly ...
Inhibition of rat heart mitochondrial electron transport in vitro: implications for the cardiotoxic action of allylamine or its ... Both acrolein and allylamine inhibited State-III, State-IV, and uncoupler stimulated respiration in a concentration dependent ... Allylamine and acrolein also displayed concentration dependent effects on respiratory enzyme activities in mitochondria ... In contrast to the results obtained with GMM, with succinate as substrate no significant differences between allylamine and ...
... allylamines, and morpholines is useful for superficial cases, in pregnant or lactating women, or if significant oral drug ...
... allylamine)-branched ferrocene (PAA-Fc) and negatively charged gold nanoparticle. The concentration of the antigen can be ... allyl-amine)-branched ferrocene and gold nanoparticles. Microchimica Acta 2011; 174, 97-105.. ...
Schweizer烯丙胺合成 (Schweizer allyl amine synthesis). *Schweizer重排反应 (Schweizer rearrangement) ...
Allylamines:. *Allylamines are antifungal medicines that work by inhibiting an enzyme involved in the synthesis of ergosterol, ... Terbinafine is a common allylamine antifungal used to treat fungal infections such as athletes foot and ringworm. ...
allylamine antifungal drug + ammonium thiosulfate antibiotic antifungal drug + aspirin-triggered resolvin D1 ...
4. Allylamines. Allylamines are a class of antifungal drugs that inhibit an enzyme called squalene epoxidase, which is involved ... Allylamines. Terbinafine, naftifine. Inhibit the synthesis of ergosterol by inhibiting squalene epoxidase, an enzyme involved ... By blocking this enzyme, allylamines prevent the synthesis of ergosterol, ultimately leading to the death of the fungus. An ...
An unprecedented asymmetric aza-Claisen rearrangement between enantioenriched α-chiral allylamines and allenones provides - ...
Lipophilic azoles and allylamines may prove much more efficacious in the treatment of feline dermatophytosis, and certainly ...
108."Carbohydrates as Chiral Templates: Stereoselective Synthesis of Chiral Homo-allylamines and b-Amino Acids". S. Laschat, H ... 112."Carbohydrates as Chiral Templates: Stereoselective Synthesis of (R)-Homo-allylamines Using L-Fucose as the Auxiliary ...
Mutation in the squalene epoxidase gene of Trichophyton interdigitale and Trichophyton rubrum associated with allylamine ...
Allylamine Allylamine and its peer markets - Ester Solvents, Acetaldehyde, Upcoming Dimethylamine Dimethylamine and its peer ...
The single-dose suppository dissolves an...Allylamines. Antifungal medications in this group attack the membranes of fungal ... Single-dose oral fluconazole versus single-dose topical miconazole for the ...Allylamines. Antifungal medications in this group ...
90. ALLYLAMINE [ԱԼԻԼԱՄԻՆ] 41. ALDICARB [ԱԼԴԻԿԱՐԲ] 91. ALLYLESTRENOL [ԱԼԻԼԷՍՏՐԵՆՈԼ] 42. ALDOSE REDUCTASE [ԱԼԴՈԶՈՐԵԴՈՒԿՏԱԶ] 92. ...
A topical allylamine antifungalcream.. J.. A short tapered course ofprednisone.. Case 6: ...
Allylamines: Group of synthetic antifungal drugs that are used locally and systemically.. Imidazole derivates: Most of the ...
Alberta Health reserves the right to make changes, without notice, to the List through the Interactive DBL(iDBL), and any such changes to the Interactive DBL(iDBL) are effective the date of the change (unless otherwise stated) and regardless of the date of publication in the paper version or updates. ...
  • Other types of drugs, such as polyenes and allylamines, work by disrupting the integrity of the fungal cell membrane. (securingpharma.com)
  • it is a synthetic allylamine derivative that inhibits squalene epoxidase, a key enzyme in sterol biosynthesis of fungi, resulting in a deficiency in ergosterol that causes fungal cell death. (medscape.com)
  • Allylamines [12] inhibit squalene epoxidase , another enzyme required for ergosterol synthesis. (wikizero.com)
  • An example of an allylamine is terbinafine, which treats fungal skin infections. (medicalnewstoday.com)
  • en] OBJECTIVES: Terbinafine resistance is increasingly reported in Trichophyton, rendering susceptibility testing particularly important in non-responding cases. (uliege.be)
  • Pharmaceutically important allylamines include flunarizine and naftifine. (wikipedia.org)
  • Allylamines work by inhibiting an enzyme that the membrane of the cell requires to operate correctly. (medicalnewstoday.com)
  • Allylamine and acrolein also displayed concentration dependent effects on respiratory enzyme activities in mitochondria actively respiring on succinate as substrate. (cdc.gov)
  • Henk de Koning, W. Nico Speckamp "Allylamine" in Encyclopedia of Reagents for Organic Synthesis, 2001, John Wiley & Sons, Weinheim. (wikipedia.org)
  • Here we report the synthesis and evaluation of a new class of poly(allylamine) (PAA) polymer grafted with hydrophobic oxadiazole (Ox) pendant group in a 5% molar monomer: pendant ratio. (strath.ac.uk)
  • While the concentration dependent inhibitory effect was statistically greater for acrolein than allylamine for State-III and uncoupler stimulated oxygen uptake, the concentrations necessary to produce these effects were in the millimolar range for both compounds. (cdc.gov)
  • Inhibition of rat heart mitochondrial electron transport in vitro: implications for the cardiotoxic action of allylamine or its primary metabolite, acrolein. (cdc.gov)
  • Allylamine, like other allyl derivatives is a lachrymator and skin irritant. (wikipedia.org)
  • Naftifine, the original member of the allylamine series, possesses only topical activity, whereas the naftifine analog terbinafine is active both topically and orally. (nih.gov)
  • Effects of naftifine and terbinafine, two allylamine antifungal drugs, on selected functions of human polymorphonuclear leukocytes. (nih.gov)
  • Terbinafine tablets are an allylamine antifungal indicated for the treatment of onychomycosis of the toenail or fingernail due to dermatophytes (tinea unguium). (nih.gov)
  • For the medical management of superficial and localized tinea corporis , topical azoles (eg, clotrimazole , ketoconazole ) and allylamines (eg, terbinafine , naftifine ) can be used to treat the affected area twice daily for 1-6 weeks on the basis of clinical response. (medscape.com)
  • Terbinafine active substance Thermicon, is an allylamine and has a broad spectrum of antifungal action. (bestpharmbuy.com)
  • Allylamine derivatives: new class of synthetic antifungal agents inhibiting fungal squalene epoxidase. (nih.gov)
  • Other authors showed that the strength of bleached softwood pulps can be increased by building polyelectrolyte multilayers (up to 8 layers) of two synthetic weak polyelectrolytes, poly(allylamine hydrochloride) (PAH) and poly(acrylic acid) (PAA), (Wågberg et al. (ncsu.edu)
  • The effects of a double polyelectrolyte adsorption of poly(allylamine hydrochloride) (PAH) and xylan (Xyl) on a recycled unbleached softwood kraft pulp were studied. (ncsu.edu)
  • We hypothesized that allylamine (AA) induces subendocardial necrosis in mammals via coronary artery (CA) vasospasm. (nih.gov)
  • 1972. Myocardial fibrosis and smooth muscle cell hyperplasia in coronary arteries of allylamine-fed rats. (nih.gov)
  • abstract = "In this work, polyelectrolyte complexes (PECs) were formed by adding polyacrylic acid (PAA) or 4-O-methylglucuronoxylan (Xyl) on poly(allylamine hydrochloride) (PAH) solutions, at different ionic strength and neutral pH. (vtt.fi)
  • abstract = "An evanescent-wave optical fibre sensor modified with tetrakis-(4-sulfophenyl) porphine (TSPP) and poly(allylamine hydrochloride) (PAH) bilayers using layer-by-layer (LbL) electrostatic self-assembly was tested to measure the gas emitted from human skin. (elsevierpure.com)
  • The allylamines are a new class of antifungal drugs that inhibit ergosterol synthesis at the level of squalene epoxidase. (nih.gov)
  • This in vitro profile is reflected by the clinical effectiveness of this allylamine in the treatment of dermatophyte infections. (nih.gov)