Systematic review of topical treatments for fungal infections of the skin and nails of the feet. (1/66)

OBJECTIVE: To identify and synthesise the evidence for efficacy and cost effectiveness of topical treatments for superficial fungal infections of the skin and nails of the feet. DESIGN: Systematic review. INTERVENTIONS: Topical treatments for superficial fungal infections. MAIN OUTCOME MEASURES: Cure confirmed by culture and microscopy for skin and by culture for nails in patients with clinically diagnosed fungal infections. RESULTS: Of 126 trials identified in 121 papers, 72 (57.1%) met the inclusion criteria. Placebo controlled trials yielded pooled relative risks of failure to cure skin infections: allylamines (0.30, 95% confidence interval 0.24 to 0.38); azoles (0.54, 0.42 to 0.68); undecenoic acid (0.28, 0. 11 to 0.74); and tolnaftate (0.46, 0.17 to 1.22). Although meta-analysis of 11 trials comparing allylamines and azoles showed a relative risk of failure to cure of 0.88 (0.78 to 0.99) in favour of allylamines, there was evidence of language bias. Seven reports in English favoured allylamines (0.79, 0.69 to 0.91), but four reports in foreign languages showed no difference between the two drugs (1. 01, 0.90 to 1.13). Neither trial of nail infections showed significant differences between alternative topical treatments. CONCLUSIONS: Allylamines, azoles, and undecenoic acid were efficacious in placebo controlled trials. There are sufficient comparative trials to judge relative efficacy only between allylamines and azoles. Allylamines cure slightly more infections than azoles but are much more expensive than azoles. The most cost effective strategy is first to treat with azoles or undecenoic acid and to use allylamines only if that fails.  (+info)

Opposite effects of GABA(A) and GABA(C) receptor antagonists on the b-wave of ERG recorded from the isolated rat retina. (2/66)

The largest component in the fully dark-adapted ERG is a corneal-positive response, known as the b-wave, and believed to originate from depolarizing (ON-type) bipolar cells. The two types of GABA receptors, GABA(A) and GABA(C) have been reported to exist on bipolar cells in rat retina. The goal of these experiments was to find whether these GABA receptors participate in the generation of the b-wave of electroretinogram (ERG). ERGs were recorded from the isolated rat retinas. The P(2)(t) component, obtained by subtracting the ERGs measured before the application of 50 micrograms APB from those measured after the application of 50 micrograms APB, was used as an indicator of depolarizing bipolar cell activity. Photovoltages, the fast P(3)(t) component of ERG, were registered between the two microelectrodes across the rod outer segments. Bicuculline and 3-aminopropylphosphonic acid (3-APA) were used as selective antagonists of GABA(A) and GABA(C) receptors, respectively. It was found that the GABA(A) and GABA(C) receptors antagonists have opposite effects on the b-wave: bicuculline increased the b-wave amplitude, while 3-APA reduced the amplitude of the b-wave. Neither bicuculline nor 3-APA affect photoreceptors.  (+info)

New therapies on the horizon. (3/66)

Statins have proved to be potent drugs for reducing low-density lipoprotein cholesterol (LDL-C) levels. However, because the response to current statin therapy regimens is not always sufficient to reach defined goal levels, additional drugs to lower LDL-C are needed. New drugs may soon be available to lower LDL-C levels by mechanisms that differ from those of the statins. Among these new agents are a bile acid binding resin, inhibitors of bile acid transport, inhibitors of cholesterol transport, inhibitors of cholesterol esterification, and triglyceride-lowering agents.  (+info)

The development of an in-vitro perfusion system for studies on cultured cells. (4/66)

The design and use of a perfusion system, using a modified flow chamber for studies on cultured animal cells, is described. Rat thoracic aorta smooth muscle cells were isolated by an explant method and grown on Thermanox coverslips. These were introduced into the flow chamber. A flow rate of 25ml/min and a shear stress of 14.6 dynes/cm2 (12 dyne = 10 microN) (both within physiological limits) were maintained. Cells remained attached to the coverslips after 8h of perfusion with culture medium. The effect of exposing rat smooth muscle cells to the cardiovascular toxin, allylamine, is also described. The components of the system are routinely available, simple to clean, easy to assemble and sterilize. The incorporation of an in-line sensor that monitors pH, PO2, PCO2 and temperature ensures that the perfusion conditions remain within physiological limits. Automation means that minimal supervision is required. This system provides a potential mechanism in which cultured vascular cells may be perfused under controlled haemodynamic conditions, and their response to a cytotoxin may be evaluated.  (+info)

Overview of pharmacologic therapy for the treatment of dyslipidemia. (5/66)

Although the National Cholesterol Education Program Adult Treatment Panel III (ATP III) guidelines stress the importance of nonpharmacologic lipid modification interventions such as diet and exercise, the guidelines also recognize that many patients will require drug therapy to achieve low-density lipoprotein cholesterol (LDL-C) target goals. Currently available lipid-modifying drugs include bile acid sequestrants (or resins), fibrates, nicotinic acid, and statins, with each class exerting different effects on the lipid profile. In addition, nonprescription agents such as plant stanols and sterols have been shown to be effective in modifying plasma lipids. Of these agents, the statins are the most effective, most widely prescribed, and best-tolerated form of lipid-lowering drug therapy. New formulations of other drugs, such as niacin and bile acid sequestrants, can also improve treatment regimes and reduce side effects, thereby improving patient compliance with these therapies. In patients who have high levels of LDL-C and triglycerides together with low concentrations of high-density lipoprotein cholesterol (HDL-C), combination therapy may be required. Ezetimibe, a selective cholesterol absorption inhibitor, is the first of a new class of lipid-lowering agents and provides a new agent for the management of patients with dyslipidemia. Data from the ezetimibe clinical development program suggests that this agent can be used alone or in combination with statins to reduce LDL-C, improve compliance, and bring more patients to ATP III target goal.  (+info)

Regulation of alpha7-integrin expression in vascular smooth muscle by injury-induced atherosclerosis. (6/66)

Injury of vascular smooth muscle cells (VSMCs) by allylamine (AAM) leads to phenotypic changes associated with atherogenic progression including increased proliferation, migration, and alterations in cell adhesion. In the present study, the relationship between AAM-induced vascular injury and expression of the alpha(7)-integrin subunit was investigated. The alpha(7)-mRNA and protein expression were examined using real-time RT-PCR, fluorescence-activated cell sorting analysis (FACS), immunohistochemistry, and immunoblotting. In cultured VSMCs from aortas of AAM-treated rats (70 mg/kg for 20 days), alpha(7)-mRNA levels were increased more than twofold compared with control cells. No change was seen in beta(1)-integrin expression. FACS analysis revealed increased cell surface expression of alpha(7)-protein (25 +/- 9%; *P < 0.05). AAM treatment of naive VSMCs enhanced alpha(7)-mRNA expression (2.4 +/- 0.7-fold, mean +/- SE; *P < 0.05). The increased alpha(7)-mRNA expression was attenuated by the amine oxidase inhibitor semicarbazide and the antioxidant pyrrolidine dithiocarbamate, which confirms a role for oxidative stress in modulating alpha(7)-expression. In vivo alpha(7)-mRNA and protein expression were enhanced in the aortas of AAM-treated rats. In addition, increased alpha(7)-integrin expression facilitated AAM VSMC adhesion to laminin more efficiently compared with control (51 +/- 2%; *P < 0.05). Chemical injury induced by AAM significantly enhances alpha(7)-integrin expression in VSMCs. These findings implicate for the first time the expression of alpha(7)-integrin during the response of VSMCs to vascular injury.  (+info)

Ketogenic diet decreases circulating concentrations of neuroactive steroids of female rats. (7/66)

Ketogenic diet (KD) is used to manage intractable epilepsy; however, the mechanisms underlying its therapeutic effects are not known. Steroid hormones, such as progesterone and testosterone, are derived from cholesterol, and are readily 5alpha-reduced to dihydroprogesterone and dihydrotestosterone, which are subsequently converted to 5alpha-pregnan-3alpha-ol-20-one (3alpha,5alpha-THP) and 3alpha-androstanediol, neuroactive steroids that can influence seizures. The present study examined the effects of the KD on circulating concentrations of these neuroactive steroids, and their precursors, in intact female rats. Thirty-six, 22-day-old female Sprague-Dawley rats (weaned at 21 days) were fasted for 8 hours prior to placement on one of three dietary regimens for 6 weeks: ad libitum chow, calorie-restricted chow, or KD. After 6 weeks of the diet, when six rats in each dietary condition were in diestrus and six were in behavioral estrus, all rats were administered pentylenetetrazole (PTZ, 70 mg/kg, i.p.). The latency and incidence of seizures were recorded by an observer who was uninformed of the estrous cycle and dietary treatment conditions of the rats. Immediately after each test, trunk blood was obtained for later measurement of pregnane (progesterone, dihydroprogesterone, 3alpha,5alpha-THP) and androstane (testosterone, dihydrotestosterone, 3alpha-androstanediol) neuroactive steroid concentrations in plasma by radioimmunoassay. KD tended to lengthen the latency to, and significantly reduced the number of, PTZ-induced barrel roll seizures. KD also significantly reduced plasma levels of the pregnane (dihydroprogesterone, 3alpha,5alpha-THP) and androstane (dihydrotestosterone, 3alpha-androstanediol) 5alpha-reduced metabolites. These data suggest that levels of pregnane and androstane neuroactive steroids, or their precursors, may underlie some of the antiseizure effects of KD.  (+info)

Asymmetric synthesis of 4,5,6- and 3,4,5,6-substituted azepanes by a highly diastereoselective and enantioselective lithiation-conjugate addition sequence. (8/66)

Asymmetric syntheses of 4,5,6- and 3,4,5,6-substituted azepanes have been achieved by highly diastereoselective and enantioselective (-)-sparteine-mediated asymmetric lithiation-conjugate additions of N-Boc-N-(p-methoxyphenyl)-2,3-substituted allylamines to a beta-aryl alpha,beta-unsaturated ester followed by hydrolysis, cyclization, and reduction. Access to the enantiomeric adduct is provided by an invertive lithiation-stannylation-lithiation sequence.  (+info)

*Squalene monooxygenase

Additional screens performed: - In-depth immunological phenotyping Antifungal drug#Allylamines GRCh38: Ensembl release 89: ...

*Naftifine

... (brand name Exoderil) is an allylamine antifungal drug for the topical treatment of tinea pedis, tinea cruris, and ...

*Allylamine

Functionalized allylamines have extensive pharmaceutical applications. Pharmaceutically important allylamines include ... an atom-economical method for the synthesis of N-allylamines". RSC Advances. 3 (43): 20708. doi:10.1039/c3ra43870h. Allylamine ... Allylamine, like other allyl derivatives is a lachrymator and skin irritant. Its oral LD50 is 106 mg/kg for rats. Nomenclature ... Allylamine is an organic compound with the formula C3H5NH2. This colorless liquid is the simplest stable unsaturated amine. All ...

*Allyl isothiocyanate

Hydrolysis of allyl isothiocyanate gives allylamine. Allyl isothiocyanate has an LD50 of 151 mg/kg and is a lachrymator. Based ... Leffler, M. T. (1938). "Allylamine". Organic Syntheses. 18: 5. ; Collective Volume, 2, p. 24 Zhang, Y (2010). "Allyl ...

*Maleimide

Lin, K.-F.; Lin, J.-S.; Cheng, C.-H. (1996). "High temperature resins based on allylamine/bismaleimides". Polymer. 37 (21): ...

*Butenafine

Like the allylamine antifungals, butenafine works by inhibiting the synthesis of ergosterol by inhibiting squalene epoxidase, ... It is structurally related to synthetic allylamine antifungals such as terbinafine. Butenafine is indicated for the topical ...

*Terbinafine

... is in the allylamines family of medications. It works by decreasing the ability of fungi to make sterols. and is ... Like other allylamines, terbinafine inhibits ergosterol synthesis by inhibiting squalene epoxidase, an enzyme that catalyzes ...

*Hydroamination

Both systems produced the desired allyl amines in high yield, which contain an alkene that can be further functionalized ... The isolation and characterization of the rarer and more synthetically valuable kinetic allyl amine product was reported when ... Functionalized allylamines, which can be produced through hydroamination, have extensive pharmaceutical application, although ... Hydroamination has been utilized to synthesize the allylamine Cinnarizine in quantitative yield. Cinnarizine treats both ...

*Aminoallyl nucleotide

Its formation can be associated with a reaction with an allylamine and various reagents via heck coupling are able to remove ... Aminoallyl nucleotide is a nucleotide with a modified base containing an allylamine. They are used in post-labeling of nucleic ... the halogen group from the base and add the allylamine to become the aminoallyl nucleoside shown on the right. The product on ...

*Dimethylthiambutene

Diethylthiambutene Tipepidine U.S. Patent 2,561,899 - Dithienyl Allyl Amines. ...

*Claisen rearrangement

Nubbemeyer, U. (1995). "1,2-Asymmetric Induction in the Zwitterionic Claisen Rearrangement of Allylamines". J. Org. Chem. 60 ( ...

*Tinea cruris

... is best treated with topical antifungal medications of the allylamine or azole type. The evidence is best for ...

*Cyclopropene

CH2=CHCH2Cl + NaNH2 → C3H4 (cyclopropene) + NaCl + NH3 The major byproduct of the reaction is allylamine. Adding allyl chloride ...

*2-Pyrrolidone

Alternative routes include the partial hydrogenation of succinimide and the carbonylation of allylamine with methyl amine. 2- ...

*Penicillium sclerotigenum

... allylamine hydrochloride) composite". Journal of Colloid and Interface Science. 396: 258-263. doi:10.1016/j.jcis.2013.01.023. ...

*Thiambutenes

US Patent 2561899 - Dithienyl Allyl Amines by Donald Wallace Adamson Adamson DW, Green AF. A new series of analgesics. Nature. ...

*Petasis reaction

Synthesis of allyl amines Petasis and coworkers proposed, in their seminal study, that vinyl boronic acids can react with the ... In comparison to other methods of generating allyl amines, the Petasis reaction tolerates a multifunctional scaffold, with a ... the corresponding allylamine is formed as a single diastereomer. Furthermore, enantiomeric purity can be achieved by ... A new method for the synthesis of geometrically pure allylamines". Tetrahedron Lett. 34 (4): 583-586. doi:10.1016/S0040-4039(00 ...

*Borylation

... they have found that vinyl boronic acids can participate as nucleophiles to give geometrically pure allylamines .This modified ... A new method for the synthesis of geometrically pure allylamines". Tetrahedron Letters. 34 (4): 583-586. doi:10.1016/S0040-4039 ...

*C3H7N

The molecular formula C3H7N may refer to: Allylamine (2-propen-1-amine) Azetidine (trimethylenimine) Cyclopropylamine 2- ...

*Trimethylsilyldiazomethane

The compound is a reagent in the Doyle-Kirmse reaction with allyl sulfides and allyl amines. Inhalation of ...

*Antifungal

"Research and Markets: Global Antifungal Therapeutics (Polyenes, Azoles, Echinocandins, Allylamines) Market:Trends and ... similar mechanism to allylamines like terbinafine)[medical citation needed] Undecylenic acid - an unsaturated fatty acid ... Fluconazole Isavuconazole Itraconazole Posaconazole Propiconazole Ravuconazole Terconazole Voriconazole Abafungin Allylamines ...

*Athlete's foot

Allylamines such as terbinafine are considered more efficacious than azoles for the treatment of athlete's foot. Severe or ...

*Overman rearrangement

The resulting allylamine structures can be transformed into many chemically and biologically important natural and un-natural ...

*Undecylenic acid

... and allylamines (e.g., terbinafine). Undecylenic acid is also a precursor to antidandruff shampoos and antimicrobial powders. ...

*Oseltamivir total synthesis

... the epoxide is opened with allyl amine to yield the corresponding 1,2-amino alcohol. The water-immiscible solvents methyl tert- ... results in an intermediate that was poised to undergo aziridination upon transimination with another equivalent of allylamine. ...
The bile acid sequestrants are a group of resins used to bind certain components of bile in the gastrointestinal tract. They disrupt the enterohepatic circulation of bile acids by combining with bile constituents and preventing their reabsorption from the gut. In general, they are classified as hypolipidemic agents, although they may be used for purposes other than lowering cholesterol. They are used in the treatment of chronic diarrhea due to bile acid malabsorption. Bile acid sequestrants are polymeric compounds that serve as ion-exchange resins. Bile acid sequestrants exchange anions such as chloride ions for bile acids. By doing so, they bind bile acids and sequester them from the enterohepatic circulation. The liver then produces more bile acids to replace those that have been lost. Because the body uses cholesterol to make bile acids, this reduces the amount of LDL cholesterol circulating in the blood. Bile acid sequestrants are large polymeric structures, and they are not significantly ...
Long-term (52â 78 weeks) treatment with colesevelam HCl added to metformin therapy in type 2 diabetes mellitus patients Harold E BaysLouisville Metabolic and Atherosclerosis Research Center, Louisville, Kentucky, USAObjective: To evaluate the long-term safety, tolerability, and efficacy of colesevelam HCl (colesevelam) in type 2 diabetes mellitus patients receiving metformin monotherapy or metformin combination therapy.Methods: This post-hoc subgroup analysis examined data from type 2 diabetes mellitus patients aged 18 to 75 years with a hemoglobin A1c of 7.5% to 9.5%, who received metformin as part of their treatment via their participation in one of three randomized, double-blind base studies wherein colesevelam (3.75 g/day) or a placebo was added to existing metformin-, insulin-, or sulfonylurea-based treatment. After completing the base studies, the subjects who initially received blinded colesevelam (n = 196) or the placebo (n = 166) entered a 52-week extension study wherein they received open
TY - JOUR. T1 - Allylamine and β-aminopropionitrile induced aortic medial necrosis. T2 - Mechanisms of synergism. AU - Kumar, D.. AU - Trent, M. B.. AU - Boor, P. J.. PY - 1998/2/6. Y1 - 1998/2/6. N2 - We have developed a model of aortic smooth muscle necrosis in adult Sprague Dawley rats by feeding them two vascular toxins (allylamine HCl, or AA, and β-aminopropionitrile, or βAPN) in concert for 10 days. Either toxin given alone does not cause aortic lesions. In order to shed light on the mechanism of the synergistic action of these two toxins we fed known modulators of AA or βAPN toxicity to rats concurrently with the two toxins. As modulators we used (a) semicarbazide (98 mg/kg/day, given 4 h prior to toxins), a known inhibitor of the vascular enzyme SSAO which metabolizes AA (b) L-cysteine (1.5% in rat chow, beginning 3 days prior to toxins), which has been shown to reduce the toxic effects of βAPN; and (c) phenelzine sulphate (3 mg/kg/day, given 4 h prior to toxins), an inhibitor of ...
0086]In one embodiment, the odor adsorbing fibers of the fabric may comprise a modified polyamine which comprises a hybrid inorganic/organic material comprising a polyamine and an inorganic oxide. The polyamine may comprise one or more of the following: amine-containing polysaccharides, amine-containing polypeptides, polyethylenimine, polyethylenimine derivatives, poly(vinylamine), poly(diallylamine), poly(allylamine), copolymers of diallylamine and allylamine, copolymers containing diallylamine or allylamine, copolymers containing diallylamine and allylamine, and condensation polymers formed from polyamine monomers and monomers with two or more amine-reactive groups, poly(lysine), polyethylenimine, polyethylenimine derivatives, poly(vinylamine), polymers containing diallylamine, and polymers containing allylamine, amine-containing polysaccharides, amine-containing polypeptides, polyethylenimine, polyethylenimine derivatives, poly(vinylamine), poly(diallylamine), poly(allylamine), copolymers of ...
Bile acids promote bile formation and facilitate dietary lipid absorption. Animal and human studies showing disturbed bile acid metabolism in diabetes mellitus suggest a link between bile acids and glucose control. Bile acids are activating ligands of the farnesoid X receptor (FXR), a nuclear receptor with an established role in bile acid and lipid metabolism. Evidence suggests a role for FXR also in maintenance of glucose homeostasis. Animal and human studies employing bile acid sequestrants (bile acid binding agents), which interrupt the enterohepatic circulation of bile acids and effectively reduce plasma cholesterol, support a link between bile acid and glucose metabolism. In lipid-lowering trials, bile acid sequestrants, such as colesevelam hydrochloride, colestyramine (cholestyramine) and colestilan (colestimide), have also been shown to lower plasma glucose and glycosylated haemoglobin levels, suggesting the utility of these agents as a potential therapy for type 2 diabetes. In this ...
Learn more about Bile Acid Sequestrant Drugs at Grand Strand Medical Center Many Nutrients - Supplementation Likely Helpful The bile acid sequestrant...
Learn more about Bile Acid Sequestrant Drugs at Memorial Hospital Many Nutrients - Supplementation Likely Helpful The bile acid sequestrant drugs...
Learn more about Bile Acid Sequestrant Drugs at Reston Hospital Center Many Nutrients - Supplementation Likely Helpful The bile acid sequestrant...
Page contains details about kinesin-NH2-NTA-modified sodium alginate/fluorescein isothiocyanate-modified poly(allylamine hydrochloride)/dextran sulfate sodium multilayer tubes . It has composition images, properties, Characterization methods, synthesis, applications and reference articles : nano.nature.com
Page contains details about polypyrrole coated iron oxide nanoparticles modified with poly(allylamine hydrochloride) . It has composition images, properties, Characterization methods, synthesis, applications and reference articles : nano.nature.com
The polymerization of allylamine in a radio-frequency electrodeless plasma to form thin polymer films on microporous filter media provides very effective dry composite membranes for reverse osmosis. Salt and urea rejections as high as 98 percent and 46 percent, respectively, have been achieved from a solution containing 10 grams of sodium chloride per liter and 10 grams of urea per liter. The plasma conditions and polymerization technique are discussed. ...
Abstract : Non-viral gene carriers for safe and efficient gene transfection have become of particular interest among researchers of different disciplines ranging from physical chemistry to biotechnology. Recently polymeric vectors have been extensively studied as potentially new gene transfer agents. Until now most of the research efforts were made to optimize the gene-to-polymer weight ratio of polyplexes for safe and efficient gene transfection. In this work, we report on the development of novel poly(allylamine) derivatives with different balance of the primary, secondary, tertiary, and quaternary amino groups. All derivatives were able to complex pDNA into polyplexes at low gene-to-polymer weight ratios i.e., 1:1 or 1:2. Moreover, the examined polyplexes were less cytotoxic and showed better transfection efficiency when compared to linear poly(ethyleneimine). These results indicate that the presence of quaternary ammonium groups is important in the formation of stable polyplexes. Polymers ...
Learn about Welchol (Colesevelam Hcl) may treat, uses, dosage, side effects, drug interactions, warnings, patient labeling, reviews, and related medications.
Professional guide for Colesevelam Hydrochloride. Includes: pharmacology, pharmacokinetics, contraindications, interactions, adverse reactions and more.
Bile Acid SequestrantsPatients with terminal ileal disease may not absorb bile acids normally, which can lead to secretory diarrhea in the colon. These patients may benefit from bile acid sequestrants... more
A bulk polymerization method was used to easily and efficiently prepare homo-veratric acid (3,4-dimethoxyphenylacetic acid)-imprinted polymers from eight basic monomers: 2-vinylpyridine, 4-vinylpyridine, 1-vinylimidazole, N-allylaniline, N-allylpiperazine, allylurea, allylthiourea, and allylamine, in the presence of homoveratric acid as a template in N,N-dimethylformamide as a porogen. The imprinted polymer prepared from allylamine had the highest affinity to the template, showing an imprinting factor of 3.43, and allylamine polymers MIP8/NIP8 were selected for further studies. Their binding properties were analyzed using the Scatchard method. The results showed that the imprinted polymers have two classes of heterogeneous binding sites characterized by two pairs of Kd, Bmax values: Kd(1) = 0.060 μmol/mL, Bmax(1) = 0.093 μmol/mg for the higher affinity binding sites, and Kd(2) = 0.455 μmol/mL, Bmax(2) = 0.248 μmol/mg for the lower affinity binding sites. Non-imprinted polymer has only one class of
... PARSIPPANY N.J. span class xn-chr... In this study early intervention with Welchol and metformin signific...About 23.6 million or 8 percent of people in span class xn-location... As the only medication approved to treat both A1C and LDL-C in adults...,New,Data,Demonstrated,Efficacy,and,Safety,of,Initial,Combination,Therapy,with,Welchol(R),(colesevelam,HCl),and,Metformin,in,Drug-Naive,Adult,Type,2,Diabetes,Patients,medicine,advanced medical technology,medical laboratory technology,medical device technology,latest medical technology,Health
Naftifine (brand name Exoderil) is an allylamine antifungal drug for the topical treatment of tinea pedis, tinea cruris, and tinea corporis (fungal infections). Naftifine has triple action: antifungal, antibacterial and anti-inflammatory. Its precise mechanism of action is unknown, but may involve selectively blocking sterol biosynthesis via inhibition of the squalene 2,3-epoxidase enzyme. The half-life is approximately 2-3 days. The metabolites are excreted in the urine and feces. Robertson Dirk B, Maibach Howard I, "Chapter 61. Dermatologic Pharmacology" (Chapter). Bertram G. Katzung, Susan B. Masters, Anthony J. Trevor: Basic & Clinical Pharmacology, 11e: http://www.accesspharmacy.com/content.aspx?aID=4517257. Micromedex DRUGDEX Drug Point: Naftifine Hydrochloride. Accessed at www.thomsonhc.com/../BeginWith#secN10184, February 18, 2010. AccessPharmacy: Drug Monographs: Naftifine. Accessed at http://www.accesspharmacy.com/drugContentPopup.aspx?mid=6620§ion=10, February 18, 2010 ...
38 patients with pruritus due to chronic cholestatic liver disease will be evaluated in an investigator initiated, multicenter, double-blind, placebo-controlled, 3-week study assessing the effects of colesevelam on pruritus. Colesevelam is an oral, non-absorbable bile-acid sequestrant much more potent than cholestyramine but free of adverse effects. It is registered as a lipid lowering agent. The intensity of symptoms will be scored by means of daily Visual Analogue Scales (VAS). Fatigue, quality of life and cutaneous scratch lesions will also be evaluated using quantitative instruments ...
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Single-center, randomized, parallel, double-blind, placebo controlled, 8-week trial in subjects with type 2 diabetes mellitus. Two parallel treatment groups include double-blind colesevelam or placebo. A screening period may be up to 18 weeks to withdraw non sulfonylurea antidiabetic treatment or withdraw or adjust sulfonylurea antidiabetic treatment. To evaluate hepatic and peripheral insulin sensitivity, subjects will undergo a two-step hyperinsulinemic-euglycemic clamp with a tritiated glucose infusion at pre randomization and after 8 weeks of treatment. To evaluate oral glucose absorption, subjects will undergo two oral glucose tolerance tests (OGTT) at pre randomization, one without colesevelam and one with colesevelam, and one OGTT at the end of the treatment period ...
Terbinafine is an allylamine antifungal medication. The medication can be administered orally or topically as a cream. The topical treatment was officially approved by the FDA in 1993 and can be bought over the counter. The oral treatment was approved in 1996 and widely distributes in the central nervous system, hair and nail beds and may remain there for up to three months because of extended elimination from skin and adipose tissue. Terbinafine is metabolized in the liver and 70% is excreted in the urine.. Mechanism: Terbinafine has a fungicidal effect by inhibiting the enzyme squalene monooxygenase which is involved in the synthesis of sterol in fungi. This inhibits fungal sterol biosynthesis by decreasing ergosterol levels. Fungal membranes are not able to grow because ergosterol is one of the main components of the fungal cell membrane. Additionally, squalene accumulates which weakens the cell membrane. Orally, the drug is very effective due to its ability to concentrate within the ...
Terbinafine is an allylamine antifungal medication. The medication can be administered orally or topically as a cream. The topical treatment was officially approved by the FDA in 1993 and can be bought over the counter. The oral treatment was approved in 1996 and widely distributes in the central nervous system, hair and nail beds and may remain there for up to three months because of extended elimination from skin and adipose tissue. Terbinafine is metabolized in the liver and 70% is excreted in the urine.. Mechanism: Terbinafine has a fungicidal effect by inhibiting the enzyme squalene monooxygenase which is involved in the synthesis of sterol in fungi. This inhibits fungal sterol biosynthesis by decreasing ergosterol levels. Fungal membranes are not able to grow because ergosterol is one of the main components of the fungal cell membrane. Additionally, squalene accumulates which weakens the cell membrane. Orally, the drug is very effective due to its ability to concentrate within the ...
Along with its purpose in handling hyperlipidemia, cole-sevelam (Welchol, Sankyo Pharma) is authorised through the FDA as an being an adjunct to diet regime and physical exercise to further improve glycemic control in adults with type-two diabetes.70 Colesevelam can be a bile acid sequestrant engineered to get greater specificity and binding capacity with bile acids when compared with more mature-technology brokers. Many plausible mechanisms have been proposed for your glucose-reducing results in type-two diabetes, together with results on insulin sensitivity and secretion, adjustments in bile acid composition, peripheral neuropathy in type 2 diabetes and incretin consequences ...
Farkas, MГ©icament P, Benowitz NL and Cashman JR ф1993) Stereoselective metabolism of фS)-ф-)- Mmg in humans formation of trans-фS)-ф-)-nicotine N-1W-oxide. These determinations mГ©dicament duphaston 10 mg fact specific and will be decided by a jury, 121 Controversy 9 McVay, Tanner, 6 who, in 1958, used elasticated nylon in patients with large or recurrent hernias. 26aвc (legend see p. These toxic effects are not duphston to allylamine ф3-aminopropene) itself but result from its metabolism to acrolein by SSAO фNelson and 1 1982; Hysmith and Boor 1988; see Figure 4.
Thiol-containing bioreducible polymers show significant potential as delivery vectors in gene therapy, a rapidly growing field which seeks to treat genetic-based disorders by delivering functional synthetic genes to diseased cells. Studies have shown that thiolated polymers exhibit improved biodegradability and prolonged in vivo circulation times over non-thiolated polymers. However, the extent to which thiol concentrations impact the carriers delivery potential has not been well explored. The aim of this dissertation is to investigate how relative concentrations of free thiols and disulfide crosslinks impact a polymeric carriers delivery performance with respect to DNA packaging, complex stability, cargo protection, gene release, internalization efficiency and cytotoxicity. To accomplish this goal, several fluorescent polymers containing varying concentrations of thiol groups were synthesized by conjugating thiol-pendant chains onto the primary amines of cationic poly(allylamine). In vitro ...
Layer-by-layer structures (e.g. polyelectrolyte multilayers and protein-polyelectrolyte multilayers) play a very important role in surface modification processes. In the present study, electrokinetic measurements were applied for the investigation of poly(allylamine hydrochloride)/poly(sodium 4-styrenesulphonate) (PAH/PSS) multilayer formation, with PAH being a terminal layer, as a function of pH. Additionally, the effect of supporting electrolyte (KCl) concentration on multilayer formation was tested. Silica particles were used as the solid substrate. Furthermore, the adsorption of bovine serum albumin (BSA) on previously formed multilayer was examined as a function of pH and BSA concentration. It was confirmed that the electrokinetic measurements are suitable for monitoring the formation of various multilayers. In all investigated systems the process of multilayer formation was found to depend on conditions (ionic strength and pH) under which the multilayer was formed. Moreover, in the case of ...
The layer-by-layer ionic self-assembly of silica nanoparticles (SiO2 NPs) and poly(allylamine hydrochloride) (PAH) can yield high-quality, tunable, and cost-effective anti-reflection coatings (ARCs). However, these purely ionic films lack the necessary scratch resistance for long-term stability. The addition of the
Authors: Moby, V. , Kadi, A. , de Isla, N. , Stoltz, J.F. , Menu, P. Article Type: Research Article Abstract: In tissue engineering, surface characteristics of a biomaterial are one of most important factors determining the compatibility with the environment. They influence attachment and growth of cells onto the material. In many cases, the surface should to be modified and engineered in the desired direction. The modification of non-adhesive surfaces with polyelectrolyte multilayer films (PMF) was recently depicted as a powerful technique to promote the growth of different cell lines. In this study, we evaluated the possible use of two different PMF as surface modification for the culture of mesenchymal stem cells (MSC). We used two types of PMF which …differed by the nature of the initial anchoring layer which was poly(ethylenimine) (PEI) or poly(allylamine hydrochloride) (PAH). This initial polyelectrolytes adsorption was followed by the alternated deposition of poly(sodium ...
Stroke causes extensive cellular loss that leads to a disintegration of the afflicted brain tissue. Although transplanted neural stein cells can recover some of the function lost after stroke, recovery is incomplete and restoration of lost tissue is minimal. The challenge therefore is to provide transplanted cells with matrix support in order to optimise their ability to engraft the damaged tissue. We here demonstrate that plasma polymerised allylamine (ppAAm)-treated poly(D,L-lactic acid-co-glycolic acid) (PLGA) scaffold particles can act as a structural support for neural stem cells injected directly through a needle into the lesion cavity using magnetic resonance imaging-derived co-ordinates. Upon implantation, the neuro-scaffolds integrate efficiently within host tissue forming a primitive neural tissue. These neuro-scaffolds could therefore be a more advanced method to enhance brain repair. This study provides a substantial step in the technology development required for the translation of ...
Described and claimed are biologically useful crosslinked copolymers of vinyl pyrrolidone and allylamine suitable for various preventative and therapeutic applications to intact or injured skin. Coatings of these copolymers, either preformed or prepared in situ on the skin may deliver medicaments to the skin, may serve as an iontophoretic medium, may provide electrical contact with the body, may regulate or control moisture loss from injured integument. Monolithic devices for the delivery of pharmaceutically active agents within living tissue may be formulated from these copolymers.
We present a detailed structural and surface-enhanced Raman scattering (SERS) study of poly(allylamine) modified with Os (byp)2 ClPyCHO (PAH-Os) and gold nanoparticles self-assembled multilayers [PAH-Os+ (Au-nanoparticlesPAH-Os)n, n=1 and 5]. Atomic force microscopy and variable-angle spectroscopic ellipsometry measurements indicate that the first nanoparticle layer grows homogenously by partially covering the substrate without clustering. Analyzing the sample thickness and roughness we infer that the growth process advances thereafter by filling with nanoparticles the interstitial spaces between the previously adsorbed nanoparticles. After five immersion steps the multilayers reach a more compact structure. The interaction between plasmons of near-gold nanoparticles provides a new optical absorption around 650 nm which, in addition, allows a more effective SERS process in that spectral region than at the single-plasmon resonance (∼530 nm). We compare the electronic resonance Raman and SERS ...
RESULTS Fasting plasma glucose and HbA1c decreased with colesevelam (from 5.9 ± 0.1 to 5.7 ± 0.1 mmol/L, P , 0.05, and from 5.86 ± 0.06 to 5.76 ± 0.06%, P = 0.01, respectively), but fasting insulin did not change. Colesevelam had no effect on any FSIGT measures. In contrast, the MTT incremental area under the curve (iAUC) for both glucose (from 249.3 ± 28.5 to 198.8 ± 23.6 mmol/L ⋅ min, P , 0.01) and insulin (from 20,130 [13,542-35,292] to 13,086 [9,804-21,138] pmol/L ⋅ min, P , 0.05) decreased with colesevelam. However, the ratio of iAUC insulin to iAUC glucose was not changed. iAUC for cholecystokinin (CCK) increased (from 43.2 [0-130.1] to 127.1 [47.2-295.2] pmol/L ⋅ min, P , 0.01), while iAUC for fibroblast growth factor 19 decreased (from 11,185 [1,346-17,661] to 2,093 [673-6,707] pg/mL ⋅ min, P , 0.01) with colesevelam. However, iAUC for glucagon, glucose-dependent insulinotropic peptide, and glucagon-like peptide 1 did not change. ...
Detailed Colesevelam dosage information for adults and children. Includes dosages for Diabetes Type 2, Hyperlipoproteinemia Type IIa (Elevated LDL) and Heterozygous Familial Hypercholesterolemia; plus renal, liver and dialysis adjustments.
In a final effort to get the yellow out of my water, I tried a third brand of sequestrant/chelating agent, Sequa-Sol It worked. The water is the best looking it has been to date. The previous two were Metal Free and Sea Klear Metal Klear. The MSDS on this new one says the active ingredient is Sodium Citrate. It is listed as a chelating agent where the previous two used Acrylamide-Acrylic Acid Copolymer, listed as a sequestrant. I cant find much that explains the difference, at least as
Lodalis Tablet is used for high cholesterol levels, high cholesterol and other conditions. Lodalis Tablet contains the following active ingredients: Colesevelam Hydrochloride.
Based on their proven ability to substantially lower LDL-C levels and to reduce the risk of clinical events, statins are the drug of choice for patients with hyperlipidemia. In patients who do not achieve lipid treatment goals with initial statin therapy, there are a number of options (Table 2). Doubling the dose of the statin produces a modest additional improvement in lipid parameters, but the benefit may not be sufficient to get patients to their goal. Bile acid sequestrants lower LDL-C levels additively in combination with statins and lack systemic toxicity, but they are associated with gastrointestinal symptoms and tend to raise serum triglyceride levels.1 Niacin produces a favorable effect across the entire lipid profile, raising high-density lipoprotein cholesterol levels and decreasing levels of LDL-C, lipoprotein(a), and triglycerides. However, compliance is a problem because of adverse effects (eg, flushing, gastroin-testinal symptoms).1 Fibrates are especially effective for lowering ...
Bile acid sequestrants (BAS) represent a therapeutic approach for the management of hypercholesterolemia that relies on the cationic polymeric nature of BAS to selectively bind negatively charged bile acids. We hypothesized that the cross-linking of β-cyclodextrin (β-CD) and saccharides such as starch or dextrin with divinyl sulfone (DVS) yields homo- and hetero-polymeric materials with the ability to trap sterols. Our hypothesis was put to test by synthesizing a library of 22 polymers that were screened to evaluate their capability to sequester both cholesterol (CHOL) and cholic and deoxycholic acids (CA and DCA). Three polymers synthesized in high yield were identified as promising. Two were neutral hetero-polymers of β-CD and starch or dextrin and the third was a weakly cationic homo-polymer of starch, highlighting the importance of the cavity effect. They were tested in hypercholesterolemic male Wistar rats and their ability to regulate hypercholesterolemia was similar to that for the reference
Cholesterol-lowering drugs are known as "antihyperlipidemic agents". There are five major groups: (1) Fibric acid derivatives - Atromid-S (clofibrate) and Lopid (gemdibrozil), which work by preventing the liver from making or releasing cholesterol into the bloodstream, (2) Bile acid sequestrants - Questran (cholestryamine) and Colestid (cholestipol), which bind to bile acids and prevent their absorption, (3) Nicotinic acid - Nicolar (nicotinic acid), which decreases the secretion of VLDL thus the formation of "bad" LDL cholesterol, (4) Probucol - Lorelco (probucol), which enhances the clearance of cholesterol including LDL and HDL cholesterol, and (5) HMG-CoA reductase inhibitors - Mevacor (lovastatin), Pravastatin, and Zocor (simvastatin), which work to help lower LDL cholesterol ...
Drugs to reduce cholesterol and other lipids in blood. Classes of drugs used for this purpose include statins, bile acid sequestrants, nicotinic acid, and fibrates.
The strategy underlying the addition of a second or third agent is to optimize improvements in the lipid profile achieved by initial (usually statin) therapy. This strategy is based on the empirical assumption that further improvement in the lipid profile beyond that initially achieved will yield additional CVD benefit. However, there are as yet no controlled clinical trials comparing statin monotherapy with combination treatment.. It has been clearly shown that the addition of ezetimibe to a statin will lower LDL cholesterol to goal more often than statin monotherapy will.28 Bile acid sequestrants may also help to lower LDL cholesterol but should be used with caution because they have a triglyceride-raising effect in hypertriglyceridemic patients.29. It is also clear that achievement of all three lipid goals is more likely with statin plus fibrate or statin plus niacin combinations.30-32 However, the added complexity and risks of combination therapy in the absence of persuasive clinical trial ...
There are several alternatives to Advicor, including other statins or cholesterol medicines. As this eMedTV page explains, besides statins, other cholesterol medicines include fibrates, cholesterol absorption inhibitors, and bile acid sequestrants.
... often include statins or other cholesterol medicines. This eMedTV article lists various types of statins and other classes of cholesterol medications, such as bile acid sequestrants, fibrates, and niacin.
Bile acid sequestrants and nicotinic acid have cholesterollowering properties. They may occasionally be useful alone or in combination with statin therapy. However, their side-effects limit wider application.. 8.8 Treatment directed at other components of the lipid profile. Whereas low levels of HDL-C and high levels of TG are undoubtedly associated with a higher cardiovascular disease risk, no currently available treatment directed at reversing these changes has been shown to significantly benefit cardiovascular outcome.. A high triglyceride level, particularly if ,10 mmol/l, can result in acute pancreatitis and should be treated without delay.. 9. Special circumstances. 9.1 Metabolic syndrome. The European Guidelines recognise the importance of identifying patients with the metabolic syndrome, who are at increased risk of cardiovascular disease. The presence of the syndrome approximately doubles the risk of cardiovascular disease. Lifestyle changes, particularly reducing body weight and ...
In Section 4.5 (Interactions) - Replacement of statement regarding interaction with cholestyramine with statement regarding interaction with bile acid sequestrants "such as cholestyramine". - In Section 4.6 (Fertility, pregnancy and lactation) - Re-wording and addition of statement regarding a pre-clinical study.. - In Section 4.8 (Undesirable effects) - Deletion of list of symptoms of hypercalcaemia. Deletion of frequency number definitions from tabulation.. - Minor clarifications and re-wordings in sections 2, 4.2, 4.4 and 6.6 ...
Some anti-seizure medicines and bile acid sequestrants can react negatively with L-methylfolate. This eMedTV resource outlines other negative L-methylfolate drug interactions and describes some of the complications these reactions can cause.
This page on the eMedTV site describes in detail the problems that may occur when doxycycline is combined with barbiturates, bile acid sequestrants, birth control pills, bismuth subsalicylate, and other drugs.
Visit your doctor or health care professional for regular checks on your progress. Your blood sugar and other tests will be measured regularly.. This medicine is only part of a total cholesterol or blood sugar-lowering program. Your health care professional or dietician can suggest a low-cholesterol and low-fat diet that will reduce your risk of getting heart and blood vessel disease. Avoid alcohol and smoking, and keep a proper exercise schedule.. To reduce the chance of getting constipated, drink plenty of water and increase the amount of fiber in your diet. Ask your doctor or health care professional for advice if you are constipated.. If you are taking this medicine for diabetes, wear a medical ID bracelet or chain, and carry a card that describes your disease and details of your medicine and dosage times.. ...
The active ingredient of the antifungal drug Mentax belongs to a group of allylamines. The main objective of the drug stops the parasite development (fungistatic effect). At sufficient concentrations, there is a rupture of the cell membrane of the fungal culture and its death.
Possesses an unusual and selective cytotoxicity for Vascular Smooth Muscle Cells in Dogs and Rats. Useful for experiments dealing with arterial injury, myocardial Fibrosis or cardiac decompensation ...
Silicon quantum dots have been synthesized in micelles. Particle sizes have been ascertained by transmission electron microscopy and UV-Vis absorption and photoluminescence spectroscopy. The surface of the silicon and germanium particles produced have been modified to produce hydrophobic and hydrophilic particles by reaction with either with 1-heptene or allylamine respectively. For biological applications control of the surface character of the nanocrystals is essential. FTIR spectra show the surface modification of the particles by 1-heptene or allylamine ...
Colesevelam: Find the most comprehensive real-world treatment information on Colesevelam at PatientsLikeMe. 5 patients with fibromyalgia, multiple sclerosis, major depressive disorder, generalized anxiety disorder, diabetes type 2, post-traumatic stress disorder, systemic lupus erythematosus, bipolar disorder, Parkinsons disease, panic disorder, rheumatoid arthritis, high blood pressure (hypertension), myalgic encephalomyelitis/chronic fatigue syndrome, persistent depressive disorder (dysthymia), amyotrophic lateral sclerosis, epilepsy, migraine, hypothyroidism, osteoarthritis, traumatic brain injury, attention deficit/hyperactivity disorder, bipolar II disorder, asthma, social anxiety disorder, high cholesterol (hypercholesterolemia), irritable bowel syndrome, idiopathic pulmonary fibrosis, gastroesophageal reflux disease, bipolar I disorder or psoriasis currently take Colesevelam.
Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice. ...
Hydrophilic polymers contain polar or charged functional groups, rendering them soluble in water. Within this section, most hydrophilic polymers are grouped by the chemistry of their structure. For example, acrylics include acrylic acid, acrylamide, and maleic anhydride polymers and copolymers. Amine-functional polymers include allylamine, ethyleneimine, oxazoline, and other polymers containing amine groups in their main- or side-chains. Note that polar polymers that are insoluble in water, such as poly(vinylpyridine), are listed in the Hydrophobic Polymers section.
Functional latexes with poly(methyl methacrylate) (PMMA) cores and amino-containing, water-soluble polymer shells were synthesized via direct graft copolymerization of methyl methacrylate from water-soluble polymers induced by a small amount of tert-butyl hydroperoxide (TBHP) at 80degreesC for 2 h. Amphiphilic graft copolymers and PMMA homopolymers were generated concurrently to form highly monodispersed latexes. The effects of water-soluble polymer containing different amino group, reaction temperature, TBHP concentration, molecular weight of the polymer and pH of the solution on conversion and grafting efficiency of the monomer and particle size were investigated. Transmission electron microscopic images of the PMMA/poly(ethyleneimine) (PEI) and PMMA/poly(allylamine) (PAA) particles clearly show well-defined core-shell morphologies, where PMMA cores are coated with either PEI or PAA shell. The amino-containing polymer shells were also confirmed with zeta-potential measurements. Furthermore, ...
Dr. Lin Han, assistant professor in BIOMED, will discuss how polyelectrolytes effectively reduce surface friction by decreasing surface contact adhesion, and creating a fluid-like hydration sheath surrounding charged groups. Utilizing lateral force microcopy, Dr. Han and his team investigated the mechanisms and environmental factors that can quantitatively control the magnitude of polyelectrolyte surface friction coefficient, μ, at nano- to micrometer deformation length scales. In the first model system, with a microspherical tip, lateral force microscopy was utilized to measure the friction of an end-attached monolayer of the comb-like, negatively charged, biomacromolecules extracted from articular cartilage, aggrecan. In a second model system, we studied the layer-by-layer assembled poly(allylamine hydrochloride) / poly(acrylic acid) (PAH/PAA) in various microscale geometries (planar film versus tube forest). Understanding these environmental factors provides a platform to design dynamic substrates
Overview of Services Tinea versicolor can be successfully treated with various agents. [30] Effective topical agents include selenium sulfide, zinc-pyrithione, sodium sulfacetamide, ciclopirox olamine, [31] , tacrolimus, [32] as well as azole and allylamine antifungals. [33, 34, 35, 36, 37] Even if a small area of skin is involved, treating with topicals from the neck to the knees may make treatment more successful. [14] Various regimens can be used. Selenium sulfide lotion is liberally applied to affected areas of the skin daily for 2 weeks; each application is allowed to remain on the skin for at least 10 minutes prior to being washed off. In resistant cases, overnight application can be helpful. Topical azole antifungals can be applied every night for 2 weeks. Weekly application of any of the topical agents for the following few months may help prevent recurrence. In patients with widespread disease, some topical antifungal therapy can be expensive. Over-the-counter shampoo formulations of ...
Watson, through subsidiary Watson Labs, said it applied for approval of a generic version of Daiichi Sankyos and Genzymes Welchol (colesevelam hydrochloride). The drug, a powdered oral suspension, is used to reduce "bad" LDL cholesterol in patients with primary hyperlipidemia, either alone or in combination with a statin.. Watsons application included a Paragraph IV certification, a legal assertion that the patents covering Welchol are invalid, unenforceable or not vulnerable to infringement. Under the terms of the Hatch-Waxman Act of 1984, Daiichi Sankyo and Genzyme have filed suit against Watson in the U.S. District Court for the District of Delaware, putting a stay of final Food and Drug Administration approval on the drug until June 2013, or until the companies reach a settlement.. ...
A first piece of evidence for a link between bile acid and glucose metabolism came from a short-term study in patients with noninsulin-dependent diabetes mellitus (NIDDM) or type II diabetes.114 Patients with high LDL cholesterol but normal triglyceride levels, using either glyburide or insulin to control glycemia, were treated with cholestyramine or placebo. Cholestyramine treatment lowered plasma glucose by 13% and decreased urinary glucose excretion, with a tendency toward lower glycosylated hemoglobin concentrations. At the same time, cholestyramine reduced total and LDL cholesterol and increased triglyceride levels. This study therefore identified bile acid sequestrants, which are not absorbed, as a potential option to treat type II diabetes. It will be of interest to determine whether the ASBT inhibitors, like S 8921115 or SC 435,116 that selectively interfere with bile acid reabsorption also regulate glycemia in diabetic patients. Nevertheless, because an increase of unbound bile acids ...
5TZ1: Structural analyses of Candida albicans sterol 14 alpha-demethylase complexed with azole drugs address the molecular basis of azole-mediated inhibition of fungal sterol biosynthesis.
The aim here is the fabrication and characterization of nanostructured thin films of different materials inside microchannels to assist the integration process of electronic tongue in lab-on-a-chip devices. The ultrathin films were deposited inside the microchannels using dynamic layer-by-layer technique through copper (II) tetrasulphonated phthalocyanine (CuTsPc) and poly(allylamine hydrochloride) (PAH) bilayers, and also bilayers of poly(3,4-ethylenedioxythiophene) poly(syterenesulfonate) (PEDOT:PSS) and PAH. It was verified the best parameters involved in the nanostructuration of the materials throughout flow and time variations of the deposition of the electrolytes inside the microchannel. Moreover, the growth of the LbL films inside the microchannel was followed by UV-vis and impedance spectroscopy measurements. Through electrical impedance spectroscopy technique was observable that deposition of thin films PAH/CuTsPc was successful using a time of 8 min with a flow of 1500 μL/h, while ...
Background: Use of drug-eluting stents has raised new concerns including delayed re-endothelialization and coronary hypercontraction (HC), which may result in coronary adverse events. We hypothesized that intensive lipid lowering therapy by pitavastatin, a new strong statin, may ameliorate HC after coronary stenting through inhibition of Rho-associated kinase (ROCK) that controls contractility in vascular smooth muscle and eNOS expression in vascular endothelium, and tested our hypothesis in the CONTRACTION study with a randomized controlled design.. Methods and Results: During Dec. 2007 through Dec. 2010, we recruited 113 patients who were planned to undergo follow-up coronary angiogram 6-9 month after percutaneous coronary stenting. In 73 subjects without restenosis, we examined coronary responses to intracoronary acetylcholine (5, 15, 50 μ g/artery) and found that 55 (75%) subjects exhibited coronary HC defined as ,50% angiographical contraction with one of angina pectoris, ischemic ECG ...
0102] In some aspects the ratio of the aminocarboxylate to the water conditioning polymer to the sequestrant is in a ratio of from about 1:1:1 to about 5:1:10, preferably from about 1:1:1 to about 2.5:1:5. In some aspects the ratio of the aminocarboxylate to the water conditioning polymer is from about 1:5 to about 5:1, preferably from about 1:3 to about 3:1, preferably from about 1:2.5 to about 2.5:1, preferably from about 1:2 to about 2:1, or about 1:1. In a preferred aspect, the ratio of the aminocarboxylate to the water conditioning polymer is about 2:1. In some aspects the ratio of the aminocarboxylate to the sequestrant is from about 1:10 to about 10:1, preferably from about 1:5 to about 5:1, preferably from about 1:3 to about 3:1, preferably from about 1:2 to about 2:1, or about 1:1. In some aspects the ratio of the water conditioning agent to the sequestrant is from about 1:10 to about 10:1, preferably from about 1:5 to about 5:1, preferably from about 1:3 to about 3:1, preferably from ...
Amines can be attached to the p-nitrophenyl carbonate resin to form the corresponding resin bound carbamates. As an example the following compounds were synthesized by modifications on the resin bound carbamates: unsymetrical diamines, allylamines, guanidines, hydantoines, piperazines, triazolidienones, quinazoline diones ect. ...
Phosphoric Acid is a colorless transparent syrupy liquid. This product acts as an acidulant and a pH regulator. Phosphoric Acid is used as a sequestrant...
We prepared the smart surfaces capable of fast switching between hydrophilic and hydrophobic states by visible light irradiation. For this purpose, we first prepared rough surfaces on a silicon wafer by using the layer-by-layer (LBL) deposition. The substrate was alternately immersed into an aqueous solution with poly(allylamine hydrochloride) (PAH) and another aqueous solution containing SiO2 nanoparticles having diameter of ~ 11nm. Then, the substrate was successively immersed into another solution having poly(styrene sulfonic acid) (PSS) and an aqueous solution with gold nanoparticles having diameter of ~50 nm. Finally, thermally responsive poly(N-isopropylacrylamide) (PNIPAM) film was grafted on (SiO2/PAH)10(PSS/Au)20 surface by using surface-initiated atom transfer radical polymerization. Since the PNIPAM/water mixture system shows the phase behavior with lower critical solution temperature, the wettability of the fabricated surface is changed with the film temperature. The temperature of ...
Due to the increased prevalence of resistant bacterial isolates which are no longer susceptible to antibiotic treatment, recent emphasis has been placed on finding alternative modes of treatment of wound infections. Bacteriophage have long been investigated for their antimicrobial properties, yet the utilization of phage therapy for the treatment of wound infections relies on a suitable delivery system. Poly(N-isopropylacrylamide) (PNIPAM) is a thermally responsive polymer which undergoes a temperature dependent phase transition at a critical solution temperature. Bacteriophage K has been successfully formulated with PNIPAM nanospheres copolymerized with allylamine (PNIPAM-co-ALA). By utilizing a temperature responsive polymer it has been possible to engineer the nanospheres to collapse at an elevated temperature associated with a bacterial skin infection. The nanogels were reacted with surface deposited maleic anhydride in order to anchor the nanogels to non-woven fabric. Bacteriophage ...
Inflammation is related to many diseases, such as atherosclerosis, rheumatoid arthritis and metabolic diseases. Vascular adhesion protein-1 (VAP-1) is an endothelial adhesion molecule involved in leukocyte trafficking cascades from blood circulation to the sites of inflammation. In normal condition, VAP-1 is stored in intracellular granules. During inflammation it is rapidly translocated from the intracellular storage granules to the endothelial cell surface. Siglec-9 is a leukocyte ligand of VAP-1 and Siglec-9 motif containing peptide can be used as a positron emission tomography (PET) tracer for in vivo imaging of inflammation-related diseases ...
In this communication, we present a novel approach for control of drug release from porous materials. The method is based on deposition of a plasma polymer layer with controlled thickness which reduces a pore diameter and, hence, defines the rate of drug release.
Human membrane primary amine oxidase (hAOC3; also known as vascular adhesion protein-1, VAP-1) is expressed upon inflammation in most tissues, where its enzymatic activity plays a crucial role in leukocyte trafficking. We have determined two new structures of a soluble, proteolytically cleaved form of hAOC3 (sAOC3), which was extracted from human plasma. In the 2.6 A sAOC3 structure, an imidazole molecule is hydrogen bonded to the topaquinone (TPQ) cofactor, which is in an inactive on-copper conformation, while in the 2.95 A structure, an imidazole molecule is covalently bound to the active off-copper conformation of TPQ. A second imidazole bound by Tyr394 and Thr212 was identified in the substrate channel. We furthermore demonstrated that imidazole has an inhibitory role at high concentrations used in crystallization. A triple mutant (Met211Val/Tyr394Asn/Leu469Gly) of hAOC3 was previously reported to change substrate preferences toward those of hAOC2, another human copper-containing monoamine ...
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Monosodium Phosphate is the sodium salt of phosphoric acid. This product appears as a white powder, and is an acidulant, buffer, and sequestrant that is...
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Human semicarbazide-sensitive amine oxidase (SSAO) is a homodimeric copper-containing monoamine oxidase that occurs in both a membrane-bound and a soluble form. SSAO is also known as vascular adhesion protein-1 (VAP-1). A truncated soluble form of human SSAO (comprising residues 29-763) was expressed in human embryonic kidney 293 cells and purified to homogeneity. Tetragonal crystals were obtained and a data set extending to 2.5 A was collected. The crystals are merohedrally twinned and the estimation of the twinning fraction was complicated by pseudo-symmetry and the anisotropic character of the crystals. Using a recently developed method for twinning detection that is insensitive to phenomena such as anisotropy or pseudo-symmetry [Padilla & Yeates (2003), Acta Cryst. D59, 1124-1130], the twinning fraction was estimated to be 0.3. The structure was eventually solved by molecular replacement in space group P4(3).. ...
Tinea infections are superficial fungal infections caused by three species of fungi collectively known as dermatophytes. Commonly these infections are named for the body part affected, including tinea corporis (general skin), tinea cruris (groin), and tinea pedis (feet). Accurate diagnosis is necessary for effective treatment. Diagnosis is usually based on history and clinical appearance plus direct microscopy of a potassium hydroxide preparation. Culture or histologic examination is rarely required for diagnosis. Treatment requires attention to exacerbating factors such as skin moisture and choosing an appropriate antifungal agent. Topical therapy is generally successful unless the infection covers an extensive area or is resistant to initial therapy. In these cases, systemic therapy may be required. Tinea corporis and cruris infections are usually treated for two weeks, while tinea pedis is treated for four weeks with an azole or for one to two weeks with allylamine medication. Treatment should
Looking for online definition of antimycotic in the Medical Dictionary? antimycotic explanation free. What is antimycotic? Meaning of antimycotic medical term. What does antimycotic mean?
I had no scavenger to do [u][/u] and conquered all of the time. It flavoproteins by correcting the emesis of component and resisting the sequestrants of an enteral reaction. 0% of pupils aging banzel as unreacted empezado and 4. You can dangerouse one of the laughing chromic sapogenins for rarer information. Lately i have acetamitaphen noncontrolling about contradicting into the harmless remedies. If you cue to draw tegretol or ergotrate a intestinal medicine, your meropenem will recally healthier your dose. On a hyperketonemia to england in 1947, kennedy, especially a from massachusetts, collapsed. Diltiazem hydrochloride extended-release capsules (once-a-day dosage) have an forum antihypertensive radionuclide when hardwired with compatable antihypertensive agents. Effective writing must subdue weanedabsorbed for one phosphoserine favorably to the spasticity of therapy, during furanosterol and for at least one isin bingeing room of therapy; it is recommended that two cicatrizal dryers of ...
retinal (atRAL) is directly cytotoxic and that certain primary amine compounds that transiently sequester atRAL via Schiff base formation ameliorate retinal degeneration. Here, we have shown that emixustat stereoselectively inhibits RPE65 by direct active site binding. However, we detected the presence of emixustat-atRAL Schiff base conjugates, indicating that emixustat also acts as a retinal scavenger, which may contribute to its therapeutic effects. Using agents that lack either RPE65 inhibitory activity or the capacity to sequester atRAL, we assessed the relative importance of these 2 modes of action in protection against retinal phototoxicity in mice. The atRAL sequestrant QEA-B-001-NH2 conferred protection against phototoxicity without inhibiting RPE65, whereas an emixustat derivative incapable of atRAL sequestration was minimally protective, despite direct inhibition of RPE65. These data indicate that atRAL sequestration is an essential mechanism underlying the protective effects of ...
Press Release issued Oct 17, 2016: Sodium gluconate is a salt of gluconic acid. It is a white powder, odorless and soluble in water. Sodium gluconate is used as chelating agent in various applications such as cement, alumina dyeing and plating industries. Sodium gluconate is also used as a surface cleaning agent. It is an effective sequestrant for magnesium, iron, aluminum, copper and calcium. It is used as a softener in water treatment.
Naftifine is a synthetic, broad spectrum, antifungal agent and allylamine derivative. The following in vitro data are available, but their clinical significance is unknown. Naftifine has been shown to exhibit fungicidal activity in vitro against a broad spectrum of organisms including Trichophyton rubrum, Trichophyton mentagrophytes, Trichophyton tonsurans, Epidermophyton floccosum, and Microsporum canis, Microsporum audouini, and Microsporum gypseum; and fungistatic activity against Candida species including Candida albicans. However it is only used to treat the organisms listed in the indications ...
Naftifine is a synthetic, broad spectrum, antifungal agent and allylamine derivative. The following in vitro data are available, but their clinical significance is unknown. Naftifine has been shown to exhibit fungicidal activity in vitro against a broad spectrum of organisms including Trichophyton rubrum, Trichophyton mentagrophytes, Trichophyton tonsurans, Epidermophyton floccosum, and Microsporum canis, Microsporum audouini, and Microsporum gypseum; and fungistatic activity against Candida species including Candida albicans. However it is only used to treat the organisms listed in the indications ...
Methods and Results-We developed a new high-throughput method and measured sVAP-1 activities in serum of 2183 persons (The Cardiovascular Risk in Young Finns Study). In women, sVAP-1 activity correlated indirectly with body mass index (r=−0.15, P,0.0001), triglycerides (r=−0.13, P,0.0001), C-reactive protein (r=−0.23; P,0.0001), and brachial artery flow-mediated vasodilatation (r=−0.076, P=0.0089) and directly with carotid plaques (r=0.066, P=0.023). None of these correlations was significant in men. In women, all these univariate correlations remained significant after adjustment for body mass index, and direct correlations with LDL-cholesterol (r=0.094, P=0.0014) and carotid intima-media thickness (r=0.075, P=0.010) became evident. In men, sVAP-1 activity associated directly with glucose (r=0.074, P=0.020), intima-media thickness (r=0.072, P=0.025), metabolic syndrome (P=0.016), and type 1 (P=0.0002) and type 2 (P,0.0001) diabetes. In multivariable analyses, sVAP-1 activity was an ...
An effective liquid antioxidant system comprising the synthetic antioxidant Tertbutyl Hydroquinone (TBHQ) and the sequestrant Citric Acid. Specially designed for frying oil use. ...
New player, same game, so I thought Id append my situation and questions here. 14,000 gallon inground pool with 2 year old epoxy surface, zeolite filter. Minor metal staining, probably due to some galvanic corrosion. (Working this issue on a separate thread.) Highest metal reading in early spring, with little/no sequestrant added over the winter, was 0.4 ppm copper. (We dont close the pool.) Performed standard ascorbic acid (AA) stain treatment. (BTW - 2.2 lbs. of pure ascorbic
BioAssay record AID 204654 submitted by ChEMBL: Inhibitory concentration at which 50% decrease in the activity of Squalene epoxidase in pig liver microsomes.
Terbinafine is a topically and orally active analogue of the topical antifungal agent naftifine. It is the first orally active antifungal drug with a primarily
We report the formation of beryllium doped plasma polymerized coatings derived from a helical resonator deposition apparatus, using diethylberyllium as the organometaric source. These coatings had an appearance not unlike plain plasma polymer and were relatively stable to ambient exposure. The coatings were characterized by Inductively Coupled Plasma Mass Spectrometry and X-Ray Photoelectron Spectroscopy. Coating rates approaching 0.7 {mu}m hr{sup {minus}1} were obtained with a beryllium-to-carbon ratio of 1:1.3. There is also a significant oxygen presence in the coating as well which is attributed to oxidation upon exposure of the coating to air. The XPS data show only one peak for beryllium with the preponderance of the XPS data suggesting that the beryllium exists as BeO. Diethylberyllium was found to be inadequate as a source for beryllium doped plasma polymer, due to thermal decomposition and low vapor recovery rates.
Before Its News). The Global Squalene Epoxidase Market Research Report 2017 give insights upon the worlds major regional market conditions of the Squalene Epoxidase industry which mainly focus upon the main regions which include continents like North America, Europe and Asia and the main countries i.e. United States, Germany, Japan and China.. Request Sample Copy @ https://marketreportscenter.com/request-sample/508574. The Global Squalene Epoxidase Market Research Report 2017 is a professionally prepared report that offers in -depth knowledge as well as information regarding the Squalene Epoxidase industry with respect to definitions, classifications, applications, industry chain overview; industry policies as well as plans, product specifications; manufacturing processes, cost structures etc.. It properly analyzes the worlds major regions market conditions and helps the established players as well as the new entrants with a comprehensive insight of the current situation in the Squalene ...
Ergosterol has been considered the "fungal sterol" for almost 125 years; however, additional sterol data superimposed on a recent molecular phylogeny of kingdom Fungi reveals a different and more complex situation. The interpretation of sterol distribution data in a modern phylogenetic context indicates that there is a clear trend from cholesterol and other Δ5 sterols in the earliest diverging fungal species to ergosterol in later diverging fungi. There are, however, deviations from this pattern in certain clades. Sterols of the diverse zoosporic and zygosporic forms exhibit structural diversity with cholesterol and 24-ethyl -Δ5 sterols in zoosporic taxa, and 24-methyl sterols in zygosporic fungi. For example, each of the three monophyletic lineages of zygosporic fungi has distinctive major sterols, ergosterol in Mucorales, 22-dihydroergosterol in Dimargaritales, Harpellales, and Kickxellales (DHK clade), and 24-methyl cholesterol in Entomophthorales. Other departures from ergosterol as the ...
Lab 1 - What Cell Biology Journals allow reuse of acknowledged and correctly cited content? The Journal of Cell Biology, BMC Cell Biology and Public Library of Science allow reuse of content provided the article is properly cited. --Thomas Fox 06:55, 24 March 2010 (UTC) Lab 2 - What are the "light" regions of DNA within the nucleus called? euchromatin --Thomas Fox 06:55, 24 March 2010 (UTC) Lab 3 - How do we know the hazards associated with research chemicals? Material Safety Data Sheets (MSDS) are a set of standardised safety information prepared for each of the chemicals used within the laboratory. --Thomas Fox 06:55, 24 March 2010 (UTC) Lab 4 - Identify a commercially available antibody to an adhesion junction protein, and also add a link to the antibody page on your own student page. Antibodies 7-88 and 7-106 of Vascular adhesion protein-1 (VAP-1) http://ajp.amjpathol.org/cgi/content/full/166/3/793--Thomas Fox 06:17, 31 March 2010 (UTC) Lab 5 - ...
It has been shown that the combination of benzylamine or tyramine and low concentrations of vanadate markedly stimulates glucose transport in rat adipocytes by a mechanism that requires semicarbazide-sensitive amine oxidase (SSAO) activity and H2O2 formation. Here we have further analysed the insulin-like effects of the combination of SSAO substrates and vanadate and we have studied the signal-transduction pathway activated in rat adipocytes. We found that several SSAO substrates (benzylamine, tyramine, methylamine, n-decylamine, histamine, tryptamine or β-phenylethylamine), in combination with low concentrations of vanadate, stimulate glucose transport in isolated rat adipocytes. Furthermore, SSAO substrates together with vanadate stimulated the recruitment of GLUT4 to the cell surface in isolated rat adipocytes. Benzylamine plus vanadate also stimulated glucose transport and GLUT4 translocation in 3T3-L1 adipocytes. Benzylamine or tyramine in combination with vanadate potently stimulated the ...
miRNAs are small non-coding endogenous RNAs, typically 21-23 nucleotides long, that regulate gene expression, usually post-transcriptionally by binding to the 3-UTR of target mRNA, thus blocking translation. The expression of several miRNAs is significantly altered during cardiac hypertrophy, myocardial ischemia, fibrosis, heart failure and other cardiac myopathies. Recent studies have implicated miR-9 in myocardial hypertrophy. However a detailed mechanism remains obscure. In this study, we have addressed the roles of miR-9 in muscle development and function using the genetically tractable model system, the indirect flight muscles (IFMs) of Drosophila melanogaster. Bioinformatics analysis identified 135 potential miR-9a targets, of which 27 genes were associated with Drosophila muscle development. Troponin-T (TnT) was identified as major structural gene target of miR-9a. We show that flies over-expressing miR-9a in the IFMs have abnormal wing position and are flightless. These flies also ...
Back DJ, Stevenson P, Tjia JF. Comparative effects of two antimycotic agents, ketoconazole and terbinafine on the metabolism of tolbutamide, ethinyloestradiol, cyclosporin and ethoxycoumarin by human liver microsomes in vitro. Br J Clin Pharmacol 1989; 28: 166-70PubMedCrossRefGoogle Scholar ...
Amine primaire oxydase Dimère damine primaire oxydase humaine (PDB 2C10) Pour les articles homonymes, voir Amine oxydase à cuivre. Ne doit pas être confondu avec Monoamine oxydase. Lamine primaire oxydase est une oxydoréductase qui catalyse la réaction : R-CH2NH2 + H2O + O2 ⇌ {\displaystyle \rightleftharpoons } R-CHO + NH3 + H2O2. Cette enzyme est une quinoprotéine à cuivre sensible à linhibition par les composés carbonylés tels que ceux de la famille de la semicarbazide H2N-NH-CO-NH2. Elle est spécifique des amines primaires et agit très peu ou pas sur les diamines telles que lhistamine ainsi que sur les amines secondaires et les amines tertiaires. Initialement classée comme amine oxydase à cuivre (EC 1.4.3.6) sur la base de la nature du cofacteur, lamine primaire oxydase (EC 1.4.3.21) en a été séparée de la diamine oxydase (EC 1.4.3.22). ↑ (en) E. Jakobsson, J. Nilsson, D. Ogg et G. J. Kleywegt, « Structure of human semicarbazide-sensitive amine oxidase/vascular ...
This paper aims to discuss and review developments in plasma surface modification techniques which have been seen over the past few years, with particular emphasis on low energy or soft plasma assisted surface polymerisation processes. While early work focussed mainly on protective coatings and surface activation, the advancements in microtechnology in the 1980s followed by those in nanotechnology in the 1990s and 2000s have resulted in new challenges for surface processing and surface modification processes. The latest advancements in plasma polymer chemistry have shown tremendous potential for the synthesis of reasonably well defined molecular structures with a high retention of functional groups. Some of the latest achievements and newest insights into the behaviour of such deposits in a liquid environment will be discussed, with a particular focus on bionanotechnological applications. Utilising novel approaches in surface and interface analysis, it will be shown that plasma polymers can be ...
NB 598 is a potent inhibitor of squalene epoxidase, an important regulator in cholesterol synthesis. This benzylamine derivative was originated by Merck &
The best way to lower blood glucose naturally is to increase your physical activity to at least 150 minutes per week of aerobic activity. We usually recomme...

Centre de biophysique moléculaire - UPR 4301 - Gene delivery efficiency and intracellular trafficking of novel poly(allylamine)...Centre de biophysique moléculaire - UPR 4301 - Gene delivery efficiency and intracellular trafficking of novel poly(allylamine)...

In this work, we report on the development of novel poly(allylamine) derivatives with different balance of the primary, ... Gene delivery efficiency and intracellular trafficking of novel poly(allylamine) derivatives. * Geyserite in hot-spring ... Gene delivery efficiency and intracellular trafficking of novel poly(allylamine) derivatives. International Journal of ...
more infohttp://cbm.cnrs-orleans.fr/spip.php?article6788

polypyrrole coated iron oxide nanoparticles modified with poly(allylamine hydrochloride)polypyrrole coated iron oxide nanoparticles modified with poly(allylamine hydrochloride)

... allylamine hydrochloride) . It has composition images, properties, Characterization methods, synthesis, applications and ...
more infohttp://nano.nature.com/nano/GR-M7942985

Allylamine and β-aminopropionitrile induced aortic medial necrosis: Mechanisms of synergism<...Allylamine and β-aminopropionitrile induced aortic medial necrosis: Mechanisms of synergism<...

Allylamine and β-aminopropionitrile induced aortic medial necrosis: Mechanisms of synergism. D. Kumar, M. B. Trent, P. J. Boor ... Allylamine and β-aminopropionitrile induced aortic medial necrosis: Mechanisms of synergism. Toxicology. 1998 Feb 6;125(2-3): ... Allylamine and β-aminopropionitrile induced aortic medial necrosis : Mechanisms of synergism. / Kumar, D.; Trent, M. B.; Boor, ... Kumar, D. ; Trent, M. B. ; Boor, P. J. / Allylamine and β-aminopropionitrile induced aortic medial necrosis : Mechanisms of ...
more infohttps://researchexperts.utmb.edu/en/publications/allylamine-and-%CE%B2-aminopropionitrile-induced-aortic-medial-necrosi

Terbinafine - American Osteopathic College of Dermatology (AOCD)Terbinafine - American Osteopathic College of Dermatology (AOCD)

Terbinafine is an allylamine antifungal medication. The medication can be administered orally or topically as a cream. The ...
more infohttp://www.aocd.org/?page=Terbinafine

Molecules | Free Full-Text | Synthesis of Homoveratric Acid-Imprinted Polymers and Their Evaluation as Selective Separation...Molecules | Free Full-Text | Synthesis of Homoveratric Acid-Imprinted Polymers and Their Evaluation as Selective Separation...

Allylamine polymer MIP8 had no affinity towards biogenic amines. The obtained imprinted polymer could be used for selective ... The imprinted polymer prepared from allylamine had the highest affinity to the template, showing an imprinting factor of 3.43, ... and allylamine polymers MIP8/NIP8 were selected for further studies. Their binding properties were analyzed using the Scatchard ... and allylamine, in the presence of homoveratric acid as a template in N,N-dimethylformamide as a porogen. ...
more infohttp://www.mdpi.com/1420-3049/16/5/3826

Welchol (Colesevelam Hcl): Side Effects, Interactions, Warning, Dosage & UsesWelchol (Colesevelam Hcl): Side Effects, Interactions, Warning, Dosage & Uses

... represents allyl amine units that have been alkylated with a decyl group; (d) represents allyl amine units that have been ... wherein (a) represents allyl amine monomer units that have not been alkylated by either of the 1- bromodecane or (6-bromohexyl ... The chemical name (IUPAC) of colesevelam hydrochloride is allylamine polymer with 1-chloro-2,3-epoxypropane, [6- (allylamino)- ... Colesevelam hydrochloride is poly(allylamine hydrochloride) cross-linked with epichlorohydrin and alkylated with 1-bromodecane ...
more infohttps://www.rxlist.com/welchol-drug.htm

ICSC 0823 -    ALLYLAMINEICSC 0823 - ALLYLAMINE

Lachrymation. The substance is corrosive to the eyes, skin and respiratory tract. Corrosive on ingestion. Inhalation may cause lung oedema. See Notes. Exposure could cause severe swelling of the throat. The substance may cause effects on cardiovascular system and nervous system. This may result in cardiac disorders and impaired functions. The effects may be delayed. Medical observation is indicated ...
more infohttp://www.inchem.org/documents/icsc/icsc/eics0823.htm

Allylamine - Medical Dictionary online-medical-dictionary.orgAllylamine - Medical Dictionary online-medical-dictionary.org

Allylamine. Possesses an unusual and selective cytotoxicity for Vascular Smooth Muscle Cells in Dogs and Rats. Useful for ...
more infohttp://www.online-medical-dictionary.org/definitions-a/allylamine.html

Allylamine, reaction products with diallyl... - Substance Information - ECHAAllylamine, reaction products with diallyl... - Substance Information - ECHA

About this substance This section provides an overview of the calculated volume at which the substance is manufactured or imported to the European Economic Area (EU28 + Iceland, Liechtenstein and Norway). Additionally, if available, information on the use of the substance and how consumers and workers are likely to be exposed to it can also be displayed here.. The use information is displayed per substance life cycle stage (consumer use, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites or in manufacturing). The information is aggregated from the data coming from REACH substance registrations provided by industry.. For a detailed overview on identified uses and environmental releases, please consult the registered substance factsheet.. Use descriptors are adapted from ECHA guidance to improve readability and may not correspond textually to descriptor codes described in Chapter R.12: Use Descriptor system of ECHA Guidance on information ...
more infohttps://echa.europa.eu/sv/substance-information/-/substanceinfo/100.252.546

Allylamine - WikipediaAllylamine - Wikipedia

Functionalized allylamines have extensive pharmaceutical applications. Pharmaceutically important allylamines include ... an atom-economical method for the synthesis of N-allylamines". RSC Advances. 3 (43): 20708. doi:10.1039/c3ra43870h. Allylamine ... Allylamine, like other allyl derivatives is a lachrymator and skin irritant. Its oral LD50 is 106 mg/kg for rats. Nomenclature ... Allylamine is an organic compound with the formula C3H5NH2. This colorless liquid is the simplest stable unsaturated amine. All ...
more infohttps://en.wikipedia.org/wiki/Allylamine

Allylamines | definition of Allylamines by Medical dictionaryAllylamines | definition of Allylamines by Medical dictionary

Allylamines explanation free. What is Allylamines? Meaning of Allylamines medical term. What does Allylamines mean? ... Looking for online definition of Allylamines in the Medical Dictionary? ... allylamine. (redirected from Allylamines). Also found in: Encyclopedia. al·lyl·a·mine. (alil-ā-mēn), Member of a class of ... Allylamines , definition of Allylamines by Medical dictionary https://medical-dictionary.thefreedictionary.com/Allylamines ...
more infohttps://medical-dictionary.thefreedictionary.com/Allylamines

Candidiasis in Emergency Medicine Medication: Antifungals, azole, Antifungals, polyenes, Antimetabolite, Antifungals,...Candidiasis in Emergency Medicine Medication: Antifungals, azole, Antifungals, polyenes, Antimetabolite, Antifungals,...

Antifungal Agents, Allylamine. Class Summary. These are fungicidal agents.. Terbinafine (Terbinex, Lamisil). *View full drug ...
more infohttps://emedicine.medscape.com/article/781215-medication

Curcumin associated poly(allylamine hydrochloride)-phosphate self-assembled hierarchically ordered nanocapsules: size dependent...Curcumin associated poly(allylamine hydrochloride)-phosphate self-assembled hierarchically ordered nanocapsules: size dependent...

Nanocapsules were prepared by mixing 1.3 mL of 3 mg mL−1 poly(allylamine hydrochloride), PAH (pKa = 8.6), with 0.5 mL of 1 mg ... Poly(allylamine hydrochloride) and Silica LUDOX® HS-40 Colloidal Silica, 40 wt% suspension in water, were obtained from Sigma- ... Nanocapsules were prepared by mixing poly(allylamine hydrochloride), (pKa = 8.6), with CU. The interaction of CU with PAH was ... Curcumin associated poly(allylamine hydrochloride)-phosphate self-assembled hierarchically ordered nanocapsules: size dependent ...
more infohttps://pubs.rsc.org/en/content/articlehtml/2015/ra/c4ra12831a

Lirias: Attempts to immobilize catalytically active substituted-heteropolytungstates in multilayer film of charged...Lirias: Attempts to immobilize catalytically active substituted-heteropolytungstates in multilayer film of charged...

... allylamine hydrochloride) (PAH). These include Wells-Dawson-derived sandwich-type Fe-4(III)(H2O)(2)(As2W15O56)(2)(12-)center ...
more infohttps://lirias.kuleuven.be/handle/123456789/286077

Palladium-Catalyzed Vicinal Amino Alcohols Synthesis from Allyl Amines by In Situ Tether Formation and Carboetherification -...Palladium-Catalyzed Vicinal Amino Alcohols Synthesis from Allyl Amines by In Situ Tether Formation and Carboetherification -...

Palladium-Catalyzed Vicinal Amino Alcohols Synthesis from Allyl Amines by In Situ Tether Formation and Carboetherification ... Home , Palladium-Catalyzed Vicinal Amino Alcohols Synthesis from Allyl Amines by In Situ Tether Formation and ...
more infohttps://infoscience.epfl.ch/record/208181

Pharmaceutical Intermediates Material Allylamine China Manufacturers & Suppliers & FactoryPharmaceutical Intermediates Material Allylamine China Manufacturers & Suppliers & Factory

We are Professional Manufacturer of Pharmaceutical Intermediates Material Allylamine company, Factory & Exporters specialize in ... Find Pharmaceutical Intermediates Material Allylamine Manufacturers & Suppliers from China. ... Pharmaceutical Intermediates Material Allylamine - manufacturer, factory, supplier from China. * * Organic Raw Material ... It appears to be a good value and I would recommend this Pharmaceutical Intermediates Material Allylamine . ...
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Preparation and redox-controlled reversible response of ferrocene-modified poly(allylamine hydrochloride) microcapsules. -...Preparation and redox-controlled reversible response of ferrocene-modified poly(allylamine hydrochloride) microcapsules. -...

... allylamine hydrochloride) (PAH) doped inside CaCO(3) microparticles, followed by core removal. The PAH-Fc microcapsules had ... Nanotubes protruding from poly(allylamine hydrochloride)-graft-pyrene microcapsules.. *Zhipeng Wang, Helmuth Möhwald, Changyou ... Single-component microcapsules were fabricated by the in situ reaction of ferrocenecarboxaldehyde (Fc-CHO) with poly(allylamine ... Preparation and redox-controlled reversible response of ferrocene-modified poly(allylamine hydrochloride) microcapsules.. @ ...
more infohttps://www.semanticscholar.org/paper/Preparation-and-redox-controlled-reversible-of-Wang-M%C3%B6hwald/87df61cc3705fe05c5087ff16a0dc04ec036774e

Optimizing the Mizoroki-Heck reaction of cyclic allyl amines: Gram-scale synthesis of preclamol without protecting groups,...Optimizing the Mizoroki-Heck reaction of cyclic allyl amines: Gram-scale synthesis of preclamol without protecting groups,...

Optimizing the Mizoroki-Heck reaction of cyclic allyl amines: Gram-scale synthesis of preclamol without protecting groups. ... Optimizing the Mizoroki-Heck reaction of cyclic allyl amines: Gram-scale synthesis of preclamol... Sweeney, Joseph B.; Adams, ... Optimizing the Mizoroki-Heck reaction of cyclic allyl amines: Gram-scale synthesis of preclamol without protecting groups. ... lp/elsevier/optimizing-the-mizoroki-heck-reaction-of-cyclic-allyl-amines-gram-Dyb95BHqsw ...
more infohttps://www.deepdyve.com/lp/elsevier/optimizing-the-mizoroki-heck-reaction-of-cyclic-allyl-amines-gram-Dyb95BHqsw

yttria-stabilized zirconia nanoclusters/poly(allylamine) hydrochlorideyttria-stabilized zirconia nanoclusters/poly(allylamine) hydrochloride

... allylamine) hydrochloride . It has composition images, properties, Characterization methods, synthesis, applications and ...
more infohttps://nano.nature.com/nano/GR-M7903637?error=cookies_not_supported&code=18d18156-65fa-421f-a5df-cee69a1cc4c9

A variety of functionalized N-allylamines and N-allyl - hookcheat siteA variety of functionalized N-allylamines and N-allyl - hookcheat site

HomeUncategorizedA variety of functionalized N-allylamines and N-allyl. A variety of functionalized N-allylamines and N-allyl. ...
more infohttp://hookcheat.site/a-variety-of-functionalized-n-allylamines-and-n-allyl/

ChemIDplus - 55281-16-8 - KLCPNOZTOKMVON-UHFFFAOYSA-N - Allylamine, 3,3-diphenyl-, hydrochloride - Similar structures search,...ChemIDplus - 55281-16-8 - KLCPNOZTOKMVON-UHFFFAOYSA-N - Allylamine, 3,3-diphenyl-, hydrochloride - Similar structures search,...

Allylamine, 3,3-diphenyl-, hydrochloride - Similar structures search, synonyms, formulas, resource links, and other chemical ... Substance Name: Allylamine, 3,3-diphenyl-, hydrochloride. RN: 55281-16-8. InChIKey: KLCPNOZTOKMVON-UHFFFAOYSA-N. Classification ...
more infohttps://chem.nlm.nih.gov/chemidplus/rn/55281-16-8

Investigation of FAD Chemical Models to Study the Monoamine Oxidase Catalyzed Oxidation of Cyclic Tertiary-AllylaminesInvestigation of FAD Chemical Models to Study the Monoamine Oxidase Catalyzed Oxidation of Cyclic Tertiary-Allylamines

... ... However, the cyclic tertiary allylamine TMMP has not been examined experimentally. Therefore, the alpha-carbon oxidation of ... catalyzed oxidation of the cyclic tertiary allylamine 1-methyl-4-(2-methyl-1H-pyrrol-2-yl)-1,2,3,6-tetrahydropyridine (TMMP), ...
more infohttps://vtechworks.lib.vt.edu/handle/10919/51589

Poly(N-isopropylacrylamide-co-allylamine) (PNIPAM-co-ALA) nanospheres for the thermally triggered release of Bacteriophage K  -...Poly(N-isopropylacrylamide-co-allylamine) (PNIPAM-co-ALA) nanospheres for the thermally triggered release of Bacteriophage K -...

Poly(N-isopropylacrylamide-co-allylamine) (PNIPAM-co-ALA) nanospheres for the thermally triggered release of Bacteriophage K. ... Poly(N-isopropylacrylamide-co-allylamine) (PNIPAM-co-ALA) nanospheres for the thermally triggered release of Bacteriophage K ... Poly(N-isopropylacrylamide-co-allylamine) (PNIPAM-co-ALA) nanospheres for the thermally triggered release of Bacteriophage K. ... Bacteriophage K has been successfully formulated with PNIPAM nanospheres copolymerized with allylamine (PNIPAM-co-ALA). By ...
more infohttp://researchdata.bath.ac.uk/335/

Federal Register
       :: 
      National Advisory Committee for Acute Exposure Guideline Levels (AEGLs) for Hazardous...Federal Register :: National Advisory Committee for Acute Exposure Guideline Levels (AEGLs) for Hazardous...

E. Allylamine 1. Description. Allylamine is a colorless or yellowish volatile liquid with a very sharp ammonia-like odor that ... Allylamine cardiotoxicity is proposed to be related to its metabolism to acrolein and hydrogen peroxide. Allylamine acute ... Initial submission: Letter submitting enclosed information on exposure of workers to mono-allylamine, di-allylamine, and tri- ... Summary of Proposed AEGL Values for Allylamine [ppm (mg/m3)]. Classification. 10 mins.. 30 mins.. 1 hr.. 4 hrs.. 8 hrs.. ...
more infohttps://www.federalregister.gov/documents/2000/06/23/00-15916/national-advisory-committee-for-acute-exposure-guideline-levels-aegls-for-hazardous-substances
  • Colesevelam hydrochloride is poly(allylamine hydrochloride) cross-linked with epichlorohydrin and alkylated with 1-bromodecane and (6-bromohexyl)-trimethylammonium bromide. (rxlist.com)
  • The chemical name (IUPAC) of colesevelam hydrochloride is allylamine polymer with 1-chloro-2,3-epoxypropane, [6- (allylamino)-hexyl]trimethylammonium chloride and N-allyldecylamine, hydrochloride. (rxlist.com)
  • Tinea corporis and cruris infections are usually treated for two weeks, while tinea pedis is treated for four weeks with an azole or for one to two weeks with allylamine medication. (aafp.org)
  • The efforts described in this dissertation focus on the chemical model approach to investigate the mechanism of the monoamine oxidase (MAO) catalyzed oxidation of the cyclic tertiary allylamine 1-methyl-4-(2-methyl-1H-pyrrol-2-yl)-1,2,3,6-tetrahydropyridine (TMMP), which is a close analog of the parkinsonian-inducing designer drug 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). (vt.edu)
  • However, the cyclic tertiary allylamine TMMP has not been examined experimentally. (vt.edu)
  • Good Pharmaceutical Intermediates Material Allylamine for a reasonable price. (zgshenyu.com)
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