AlloxanNinhydrin: 2,2-Dihydroxy-1H-indene-1,3-(2H)-dione. Reagent toxic to skin and mucus membranes. It is used in chemical assay for peptide bonds, i.e., protein determinations and has radiosensitizing properties.Diabetes Mellitus, Experimental: Diabetes mellitus induced experimentally by administration of various diabetogenic agents or by PANCREATECTOMY.Trigonella: A plant genus of the family FABACEAE.Islets of Langerhans: Irregular microscopic structures consisting of cords of endocrine cells that are scattered throughout the PANCREAS among the exocrine acini. Each islet is surrounded by connective tissue fibers and penetrated by a network of capillaries. There are four major cell types. The most abundant beta cells (50-80%) secrete INSULIN. Alpha cells (5-20%) secrete GLUCAGON. PP cells (10-35%) secrete PANCREATIC POLYPEPTIDE. Delta cells (~5%) secrete SOMATOSTATIN.Blood Glucose: Glucose in blood.Glycosuria: The appearance of an abnormally large amount of GLUCOSE in the urine, such as more than 500 mg/day in adults. It can be due to HYPERGLYCEMIA or genetic defects in renal reabsorption (RENAL GLYCOSURIA).Streptozocin: An antibiotic that is produced by Stretomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.Pancreas: A nodular organ in the ABDOMEN that contains a mixture of ENDOCRINE GLANDS and EXOCRINE GLANDS. The small endocrine portion consists of the ISLETS OF LANGERHANS secreting a number of hormones into the blood stream. The large exocrine portion (EXOCRINE PANCREAS) is a compound acinar gland that secretes several digestive enzymes into the pancreatic ductal system that empties into the DUODENUM.Diabetes Mellitus, Type 1: A subtype of DIABETES MELLITUS that is characterized by INSULIN deficiency. It is manifested by the sudden onset of severe HYPERGLYCEMIA, rapid progression to DIABETIC KETOACIDOSIS, and DEATH unless treated with insulin. The disease may occur at any age, but is most common in childhood or adolescence.Endocrinology: A subspecialty of internal medicine concerned with the metabolism, physiology, and disorders of the ENDOCRINE SYSTEM.Diabetes Mellitus, Type 2: A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.Diabetes Mellitus: A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.Allium: A genus of the plant family Liliaceae (sometimes classified as Alliaceae) in the order Liliales. Many produce pungent, often bacteriostatic and physiologically active compounds and are used as VEGETABLES; CONDIMENTS; and medicament, the latter in traditional medicine.Onions: Herbaceous biennial plants and their edible bulbs, belonging to the Liliaceae.Plant Extracts: Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is evaporated away, and adjusting the residue to a prescribed standard.Hypoglycemic Agents: Substances which lower blood glucose levels.Superoxide Dismutase: An oxidoreductase that catalyzes the reaction between superoxide anions and hydrogen to yield molecular oxygen and hydrogen peroxide. The enzyme protects the cell against dangerous levels of superoxide. EC 1.15.1.1.Superoxides: Highly reactive compounds produced when oxygen is reduced by a single electron. In biological systems, they may be generated during the normal catalytic function of a number of enzymes and during the oxidation of hemoglobin to METHEMOGLOBIN. In living organisms, SUPEROXIDE DISMUTASE protects the cell from the deleterious effects of superoxides.Cytochrome c Group: A group of cytochromes with covalent thioether linkages between either or both of the vinyl side chains of protoheme and the protein. (Enzyme Nomenclature, 1992, p539)Cytochromes c: Cytochromes of the c type that are found in eukaryotic MITOCHONDRIA. They serve as redox intermediates that accept electrons from MITOCHONDRIAL ELECTRON TRANSPORT COMPLEX III and transfer them to MITOCHONDRIAL ELECTRON TRANSPORT COMPLEX IV.Xanthine Oxidase: An iron-molybdenum flavoprotein containing FLAVIN-ADENINE DINUCLEOTIDE that oxidizes hypoxanthine, some other purines and pterins, and aldehydes. Deficiency of the enzyme, an autosomal recessive trait, causes xanthinuria.Free Radicals: Highly reactive molecules with an unsatisfied electron valence pair. Free radicals are produced in both normal and pathological processes. They are proven or suspected agents of tissue damage in a wide variety of circumstances including radiation, damage from environment chemicals, and aging. Natural and pharmacological prevention of free radical damage is being actively investigated.Ficus: A plant genus of the family MORACEAE. It is the source of the familiar fig fruit and the latex from this tree contains FICAIN.Rabbits: The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.Lipids: A generic term for fats and lipoids, the alcohol-ether-soluble constituents of protoplasm, which are insoluble in water. They comprise the fats, fatty oils, essential oils, waxes, phospholipids, glycolipids, sulfolipids, aminolipids, chromolipids (lipochromes), and fatty acids. (Grant & Hackh's Chemical Dictionary, 5th ed)Insulin: A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1).Lycium: A plant genus of the family SOLANACEAE. Members contain CEREBROSIDES and SCOPOLETIN.Shallots: Mildly aromatic herb in the Allium genus used in SPICES.Tradescantia: A plant genus of the family COMMELINACEAE that is used in genotoxic bioassays.Electronic Mail: Messages between computer users via COMPUTER COMMUNICATION NETWORKS. This feature duplicates most of the features of paper mail, such as forwarding, multiple copies, and attachments of images and other file types, but with a speed advantage. The term also refers to an individual message sent in this way.Ketone Bodies: The metabolic substances ACETONE; 3-HYDROXYBUTYRIC ACID; and acetoacetic acid (ACETOACETATES). They are produced in the liver and kidney during FATTY ACIDS oxidation and used as a source of energy by the heart, muscle and brain.Starvation: Lengthy and continuous deprivation of food. (Stedman, 25th ed)Fatty Acids: Organic, monobasic acids derived from hydrocarbons by the equivalent of oxidation of a methyl group to an alcohol, aldehyde, and then acid. Fatty acids are saturated and unsaturated (FATTY ACIDS, UNSATURATED). (Grant & Hackh's Chemical Dictionary, 5th ed)KetonesPyruvatesGastrin-Releasing Peptide: Neuropeptide and gut hormone that helps regulate GASTRIC ACID secretion and motor function. Once released from nerves in the antrum of the STOMACH, the neuropeptide stimulates release of GASTRIN from the GASTRIN-SECRETING CELLS.Receptors, Bombesin: Cell surface proteins that bind bombesin or closely related peptides with high affinity and trigger intracellular changes influencing the behavior of cells. Gastrin- releasing peptide (GRP); GRP 18-27 (neuromedin C), and neuromedin B are endogenous ligands of bombesin receptors in mammals.Bombesin: A tetradecapeptide originally obtained from the skins of toads Bombina bombina and B. variegata. It is also an endogenous neurotransmitter in many animals including mammals. Bombesin affects vascular and other smooth muscle, gastric secretion, and renal circulation and function.Gastrointestinal Hormones: HORMONES secreted by the gastrointestinal mucosa that affect the timing or the quality of secretion of digestive enzymes, and regulate the motor activity of the digestive system organs.Peptides: Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.Carboxypeptidase H: A ZINC-containing exopeptidase primarily found in SECRETORY VESICLES of endocrine and neuroendocrine cells. It catalyzes the cleavage of C-terminal ARGININE or LYSINE residues from polypeptides and is active in processing precursors of PEPTIDE HORMONES and other bioactive peptides.Hyperglycemic Hyperosmolar Nonketotic Coma: A serious complication of TYPE 2 DIABETES MELLITUS. It is characterized by extreme HYPERGLYCEMIA; DEHYDRATION; serum hyperosmolarity; and depressed consciousness leading to COMA in the absence of KETOSIS and ACIDOSIS.Pinocytosis: The engulfing of liquids by cells by a process of invagination and closure of the cell membrane to form fluid-filled vacuoles.Microscopy, Electron: Microscopy using an electron beam, instead of light, to visualize the sample, thereby allowing much greater magnification. The interactions of ELECTRONS with specimens are used to provide information about the fine structure of that specimen. In TRANSMISSION ELECTRON MICROSCOPY the reactions of the electrons that are transmitted through the specimen are imaged. In SCANNING ELECTRON MICROSCOPY an electron beam falls at a non-normal angle on the specimen and the image is derived from the reactions occurring above the plane of the specimen.Glucose: A primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is used therapeutically in fluid and nutrient replacement.Anoxia: Relatively complete absence of oxygen in one or more tissues.Biological Science Disciplines: All of the divisions of the natural sciences dealing with the various aspects of the phenomena of life and vital processes. The concept includes anatomy and physiology, biochemistry and biophysics, and the biology of animals, plants, and microorganisms. It should be differentiated from BIOLOGY, one of its subdivisions, concerned specifically with the origin and life processes of living organisms.ArchivesRats, Wistar: A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.Journal Impact Factor: A quantitative measure of the frequency on average with which articles in a journal have been cited in a given period of time.ABO Blood-Group System: The major human blood type system which depends on the presence or absence of two antigens A and B. Type O occurs when neither A nor B is present and AB when both are present. A and B are genetic factors that determine the presence of enzymes for the synthesis of certain glycoproteins mainly in the red cell membrane.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.
Accelerated intimal hyperplasia and increased endogenous inhibitors for NO synthesis in rabbits with alloxan-induced hyperglycaemia. (1/243)
1. We examined whether endogenous inhibitors of NO synthesis are involved in the augmentation of intimal hyperplasia in rabbits with hyperglycaemia induced by alloxan. 2. Four weeks after the endothelial denudation of carotid artery which had been performed 12 weeks after alloxan, the intimal hyperplasia was greatly augmented with hyperglycaemia. The degree of hyperplasia was assessed using three different parameters of histopathological findings as well as changes in luminal area and intima: media ratio. 3. There were positive and significant correlations between intima:media ratio, plasma glucose, and concentrations of N(G)-monomethyl-L-arginine (L-NMMA) and N(G), N(G)-dimethyl-L-arginine (ADMA) in endothelial cells, that is, the intima:media ratio became greater as plasma glucose and endothelial L-NMMA and ADMA were increased. Furthermore, endothelial L-NMMA and ADMA were increased in proportion to the increase in plasma glucose. 4. In contrast, there were inverse and significant correlations between cyclic GMP production by carotid artery strips with endothelium and plasma glucose, between cyclic GMP production and endothelial L-NMMA and ADMA, and between the intima:media ratio and cyclic GMP production. 5. Exogenously applied L-NMMA and ADMA inhibited cyclic GMP production in a concentration-dependent manner. IC50 values were determined to be 12.1 microM for the former and 26.2 microM for the latter. The cyclic GMP production was abolished after the deliberate removal of endothelium from the artery strips. 6. These results suggest that the augmentation of intimal hyperplasia with hyperglycaemia is closely related to increased accumulation of L-NMMA and ADMA with hyperglycaemia, which would result in an accelerated reduction in NO production/release by endothelial cells. (+info)Alloxan in vivo does not only exert deleterious effects on pancreatic B cells. (2/243)
The aim of the experiment was to investigate the mechanism of harmful alloxan action in vivo. 75 mg/kg b.w. of this diabetogenic agent were administered to fasting rats. Two minutes later the animals were decapitated. It was observed that alloxan caused a distinct rise in blood insulin and glucose levels with a concomitant drop of free fatty acids. The amount of sulfhydryl groups in the liver of alloxan-treated rats was decreased and glutathione peroxidase activity was substantially higher. These results indicate that some changes observed in alloxan-induced diabetes can not only be the consequence of B cells damage by alloxan but may also be the result of its direct influence on other tissues. It was also observed that glucose given 20 min before alloxan injection only partially protected against the deleterious effects of alloxan. (+info)Intercalated duct cells in the chicken pancreatic islet with special reference to the alloxan administration. (3/243)
The intercalated duct cells were observed in the A and B islets of the chicken pancreas. These cells adhered with each other by intercellular junctional complexes at the apical side. They had many microvilli projecting into the lumen. Abluminally, they displayed extended slender cytoplasmic processes between islet endocrine cells. Administration of alloxan resulted to denser cytoplasm and a more prominent thickening of cytoplasmic processes of the intercalated duct cells, although the blood glucose levels did not show appreciable changes by the treatment. The intercalated duct epithelial cells appeared clearly as stellate cells. The lysosomes increased in size and number with passage of time after alloxan administration. The present findings may suggest that intercalated ducts are not only anatomically important as a structure passing through the islet but also play physiologically by protecting the islet endocrine cells. (+info)Reduced coronary NO production in conscious dogs after the development of alloxan-induced diabetes. (4/243)
The role of nitric oxide (NO) in the control of coronary blood flow (CBF) during the development of diabetes is unknown. To study this, mongrel dogs were chronically instrumented using sterile techniques for measurements of systemic hemodynamics and CBF. With heart rate controlled (150 beats/min), veratrine (1-10 micrograms/kg) caused dose-dependent increases in CBF; e.g., 5 mirograms/kg of veratrine increased CBF by 57 +/- 7% from 41 +/- 1.3 ml/min (P < 0.05). The dogs developed diabetes 4-5 wk after injection of alloxan (40-60 mg/kg iv, blood glucose levels were 384 +/- 18 mg/dl). After diabetes the same doses of veratrine caused smaller increases in CBF; i.e., 5 micrograms/kg of veratrine increased CBF by 32 +/- 2% (P < 0.05 compared with control) from 28 +/- 4 ml/min. ACh- and adenosine-induced coronary vasodilation were reduced after diabetes as well. In anesthetized dogs after diabetes, vagal stimulation caused smaller increases in CBF. ACh and bradykinin caused smaller increases in NO(-)(2) production in coronary microvessels from diabetic dogs. Furthermore, despite the fact that mRNA for endothelial cell NO synthase from the aorta was increased twofold with the use of Northern blotting, the protein for aortic endothelial constitutive NO synthase was reduced by 66% after diabetes, as determined by Western blotting. Our results indicate that the NO-dependent coronary vasodilation by the Bezold-Jarisch reflex is impaired in conscious dogs after diabetes. The mechanism responsible for the impaired endothelium-dependent coronary vasodilation is most likely the decreased release of NO from the endothelium. (+info)Supplementation of N-acetylcysteine inhibits NFkappaB activation and protects against alloxan-induced diabetes in CD-1 mice. (5/243)
Reactive oxygen species (ROS) are involved in the destruction of pancreatic beta cells and the development of insulin-dependent diabetes mellitus (IDDM). However, the cellular mechanism responsible for beta cell death is still unclear. We hypothesize that activation of NFkappaB by ROS is the key cellular signal in initiating a cascade of events leading to beta cell death. Thus, enhancement of pancreatic GSH, a known antioxidant and key regulator of NF-kappaB, should protect against IDDM. Weanling CD1 mice (n=5) were injected with alloxan (50 mg/kg i.v.) to induce IDDM. Using EPR spin trapping techniques, we demonstrated that alloxan generated ROS in the pancreas 15 min after administration. Activation of NFkappaB in pancreatic nuclear extracts was observed 30 min after alloxan injection, as assessed by an electrophoretic mobility shift assay. Fasting blood glucose levels were monitored for 14 days. Supplementation with N-acetylcysteine (NAC, 500 mg/kg), a GSH precursor, inhibited alloxan-induced NFkappaB activation and reduced hyperglycemia. Thus, NFkappaB activation by ROS may initiate a sequence of events leading to IDDM. Inhibition of NF-kappaB activation by NAC attenuated the severity of IDDM. This research will contribute to the understanding of the etiology of IDDM and may lead to the development of better strategies for disease prevention. (+info)Lipolysis induced by alloxan in rat adipocytes is not inhibited by insulin. (6/243)
Isolated rat adipocytes were incubated with adrenaline, adrenaline plus insulin, alloxan or alloxan plus insulin. Glycerol release was taken as a measure of lipolysis. It was observed that alloxan in the concentration of 3, 10 and 20 mmol/l intensifies lipolysis in adipocytes in the absence of adrenaline. Insulin (10(-6) mol/l) treatment of cells did not inhibit lipolysis caused by this compound, but significantly restricted lipolysis induced by adrenaline (10(-6) mol/l). It was also shown that alloxan in the concentration of 3 and 10 mmol/l intensified lipolysis stimulated by adrenaline (10(-6) mol/l). Addition of 20 mmol/l of alloxan strongly inhibited glycerol release in the presence of adrenaline. The results presented here clearly indicate that the action of alloxan concerns cells of the white adipose tissue. (+info)Resistance of ALR/Lt islets to free radical-mediated diabetogenic stress is inherited as a dominant trait. (7/243)
ALS/Lt and ALR/Lt are inbred mouse strains selected for susceptibility and resistance to alloxan (AL)-induced diabetes. Within 24-h after AL administration in vivo, ALS/Lt islets were distinguished from ALR/Lt islets by more extensive necrotic changes. Within 7 days post-AL, ALS/Lt mice exhibited hyperglycemia and hypoinsulinemia, whereas ALR/Lt mice maintained normal plasma insulin and glucose levels. We have recently shown that resistance in ALR/Lt correlated with constitutively elevated systemic (and pancreatic) free radical defense status. In the present report, we examined whether ability to detoxify free radical stress extended to the level of ALR/Lt pancreatic islets. Cultured ALS/Lt islets exposed for 5 min to increasing (0-3 mmol/l) AL concentrations in vitro exhibited an 80% decline in numbers of intact islets after a subsequent 6-day culture period, as well as a 75% reduction in islet insulin content and a 94% decrease in glucose-stimulated insulin secretory capacity. In contrast, ALR/Lt islets remained viable and retained glucose-stimulated insulin secretory capacity as well as normal insulin content. This ALR/Lt islet resistance extended to hydrogen peroxide, a free radical generator whose entry into beta-cells is not dependent on glucose transporters. The elevated antioxidant defenses previously found in ALR/Lt pancreas were extended to isolated islets, which exhibited significantly higher glutathione and Cu-Zn superoxide dismutase 1 levels compared with ALS/Lt islets. A dominant genetic trait from ALR/Lt controlling this unusual AL resistance was indicated by the finding that reciprocal F1 mice of both sexes were resistant to AL administration in vivo. A backcross to ALS/Lt showed 1:1 segregation for susceptibility/resistance, indicative of a single gene controlling the phenotype. In conclusion, the ALR/Lt mouse may provide important insight into genetic mechanisms capable of rendering islets strongly resistant to free radical-mediated damage. (+info)Protective mechanism of glucose against alloxan-induced beta-cell damage: pivotal role of ATP. (8/243)
Glucose prevents the development of diabetes induced by alloxan. In the present study, the protective mechanism of glucose against alloxan-induced beta-cell damage was investigated using HIT-T 15 cell, a Syrian hamster transformed beta-cell line. Alloxan caused beta-cell damages with DNA fragmentation, inhibition of glucose-stimulated insulin release, and decrease of cellular ATP level, but all of these beta-cell damages by alloxan were prevented by the presence of 20 mM glucose. Oligomycin, a specific inhibitor of ATP synthase, completely abolished the protective effects of glucose against alloxan-induced cell damage. Furthermore, treatment of nuclei isolated from HIT-T15 cells with ATP significantly prevented the DNA fragmentation induced by Ca2+. The results indicate that ATP produced during glucose metabolism plays a pivotal role in the protection of glucose against alloxan-induced beta-cell damage. (+info)Bertoni) on alloxan-induced diabetic rats". J Pharm Bioallied Sci. 3 (2): 242-8. doi:10.4103/0975-7406.80779. PMC 3103919 . ...
Fruit powder in alloxan-diabetic rats". Journal of Ethnopharmacology. 67 (1): 103-109. doi:10.1016/S0378-8741(99)00004-5. PMID ...
Szkudelski T (2001). "The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas". Physiol Res. 50 (6): ... Streptozotocin is now marketed by the generic drug company Sicor (Teva). Alloxan Brentjens R, Saltz L (2001). "Islet cell ... "Comparison of metabolic abnormalities in diabetes mellitus induced by streptozotocin or by alloxan". Lancet. 1 (7544): 670-1. ...
Fruit in alloxan-induced diabetic Rats". South African Journal of Botany. 88: 56-61. doi:10.1016/j.sajb.2013.04.010. ... Vivo antioxidant activities in alloxan-induced oxidative stress". Asian Journal of Pharmaceutical and Clinical Research. 6: 249 ...
with Glyburide in Alloxan Induced Diabetic Mice". Evidence-Based Complementary and Alternative Medicine. 5 (2): 159-164. doi: ... and reduced the mortality of alloxan induced diabetic mice by approximately 50%. It showed a synergistic effect with the ...
Menten, ML.; Janouch, M. (1946). "Changes in alkaline phosphatase of kidney following renal damage with alloxan". Proceedings ...
... antioxidative and nephroprotective effects of taurine in alloxan diabetic rabbits". Biochimie. 91 (2): 261-270. doi:10.1016/j. ...
On blood glucose levels in normal and alloxan-induced diabetic rats". Journal of Ethnopharmacology. 50 (1): 13-7. doi:10.1016/ ... fed hyperglycemic and alloxan-treated rabbits and rats. Davana oil is used in making perfumes of sweet and fruity fragrances. ...
Venkatesh, S., Reddy, G. D., & Reddy, B. M. (2003). Antihyperglycemic activity of Helicteres isora roots in alloxan-induced ...
Streptozotocin or alloxan may be administered to induce chronic diabetes in hamsters. Atherosclerosis may be studied with ...
"Antidiabetic and antioxidant effect of Scoparia dulcis in alloxan induced albino mice" (PDF). International Journal of ...
Strecker, A (1862). "Notiz über eine eigenthümliche Oxydation durch Alloxan" [Notice of a curious oxidation by alloxan]. ... The original observation by Strecker involved the use of alloxan as the oxidant in the first step, followed by hydrolysis: The ...
"Importance of glucagon in the control of futile cycling as studied in alloxan-diabetic dogs". Diabetologia. 30: 175-182. doi: ... reduction in pancreatic glucagon with normalization of somatostatin and decrease in insulin in normoglycemic alloxan-diabetic ...
Anti‑hyperlipidemic effect of aqueous leaf extract of Ocimum gratissimum in alloxan induced diabetic rats. Int J Med Med Sci ... Aqueous leaf extract of Ocimum gratissimum improves hematological parameters in alloxan-induced diabetic rats via its ... Effect of aqueous leave extract of Ocimum gratissimum on alloxan induced diabetic rat. PHCOG MAG Vol 1, Issue 2, 62-64 Ayinla ...
It may also be prepared by digesting alloxan with alcoholic ammonia at about 78 °C; the purple solid so formed is easily ...
Later, in 1948, while conducting experiments on alloxan effects on rats, Gyorge and Rose noted rats receiving tocopherol ... "Effect of dietary factors on early mortality and hemoglobinuria in rats following administration of alloxan". Science. 108 ( ...
Omotade, OI (2009). "Glucose-6-phosphatase activity in selected rabbit tissues of normal and alloxan induced diabetic rabbit". ...
Bartosíková, L (2007). "Examination of the antioxidative and antidiabetic effect of pomiferin in alloxan-induced diabetes ...
Although pyrimidine derivatives such as uric acid and alloxan were known in the early 19th century, a laboratory synthesis of a ... Grimaux, E. (1879). "Synthèse des dérivés uriques de la série de l'alloxane" [Synthesis of urea derivatives of the alloxan ... and alloxan. It is also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. ...
... blood lipid and antioxidation of hyperglycemic mice induced by Alloxan,"". Chinese Pharmacological Bulletin. pp. 237-240. ...
Brömme HJ, Mörke W, Peschke E (November 2002). "Transformation of barbituric acid into alloxan by hydroxyl radicals: ...
Diabetes mellitus can be experimentally induced for research purposes by streptozotocin or alloxan, which are specifically ...
... molybdate of ammonia and alloxan. In 1843, with mineralogist Johann Reinhard Blum, he proposed the name "leonhardite" for ...
... cando estaban facendo experimentos sobre os efectos do alloxan en ratas, Gyorge e Rose notaron que as ratas que recibían ... "Effect of dietary factors on early mortality and hemoglobinuria in rats following administration of alloxan". Science 108 (2817 ...
An aqueous extract of aerial parts of the plant has shown a hypoglycemic effect in alloxan-induced diabetic rabbits and mice. ...
Alloxan, sometimes referred to as alloxan hydrate, refers to the organic compound with the formula OC(N(H)CO)2C(OH)2. It is ... The name "Alloxan" emerged from an amalgamation of the words "allantoin" and "Oxalsäure" (oxalic acid). The alloxan model of ... Studies suggests that alloxan does not cause diabetes in humans. Others found a significant difference in alloxan plasma levels ... A dimeric derivative alloxantin can be prepared by partial reduction of alloxan with hydrogen sulfide. Alloxan is a toxic ...
5TG 14d post-Alloxan) after 3v alloxan. Data are means ± SEM. *P ≤ 0.05 vs. 5TG responses prior to 3v alloxan injection. ... 7-day post-3v alloxan-treated (B), and 14-day post-3v alloxan-treated (C) rats. Seven days following 3v alloxan injection, GFAP ... Experiment 2: 4v alloxan: feeding and blood glucose responses.. There were no effects of 4v alloxan on systemic 2DG-induced ... alloxan: 436 ± 8 g) nor body weight gain (saline: 101 ± 6 vs. alloxan: 95 ± 9 g) differed at the termination of the experiment ...
... suggesting that alloxan indeed was inhibiting (OGT). In order to show definitively that alloxan was inhibiting OGT activity, ... Alloxan is an inhibitor of the enzyme O-linked N-acetylglucosamine transferase.. Konrad RJ1, Zhang F, Hale JE, Knierman MD, ... Alloxan, another beta-cell toxin is a uracil analog. Since the O-GlcNAc transferase (OGT) uses UDP-GlcNAc as a substrate, we ... Together, these data demonstrate that alloxan is an inhibitor of OGT, and as such, is the first OGT inhibitor described. ...
Diabetes was induced in rats by administration of alloxan monohydrate. Root extract of,i, Z. chalybeum ,/i,was administered to ... Induction of diabetes with alloxan resulted in severe damage to the β-cells of the islets of Langerhans (Figure 2(a)). A month ... The induction of diabetes using alloxan resulted in severe damage of β-cells of the islets of Langerhans (Figure 2(b)). However ... Since alloxan caused fatal hypoglycemia due to massive insulin release by the pancreas, the rats were in addition orally given ...
... ethanol extract on alloxan-induced diabetic rats. Forty-eight albino rats (300 g) were used in this experiment... ... Alloxan Diabetes A. absinthium Blood glucose Antihyperglycemic effect Biochemical markers This is a preview of subscription ... Lenzen S (2008) The mechanisms of alloxan and streptozotocin induced diabetes. Diabetologica 51:216-226CrossRefGoogle Scholar ... The aim of our study was to evaluate the effect of Artemisia absinthium (A. absinthium) ethanol extract on alloxan-induced ...
Alloxan is most commonly used to induce diabetes in animals.. Alloxan is a β-cytotoxin and induces diabetes mellitusby damaging ... alloxan 150 mg/kg body weight i.p.); Group III: diabetic control (B) (alloxan 150 mg/kg body weight i.p.) + C (Momordica ... In this study significant hyperglycemia was achieved after alloxan (150 mg/kg body weight) injection. Alloxan induced diabetic ... In alloxan treated diabetic group, the mean value was mg/dL with individual level variations ranging from 1.11 to 1.55 mg/dL, ...
As expected in alloxan treated rats, there was significant increase in blood glucose, CHL and TGL levels. Oral treatment with ... Alloxan, antidiabetic activity, Clerodendron phlomoidis, ethanol extract. Diabetes has been known to medical sciences longer ... Effect of Vinca rosea extracts in treatment of alloxan diabetic rats in male albino rats Indian J Exp Biol 2001;39:748. ... The extract was screened for hypoglycemic activity in alloxan-induced diabetic rats (120 mg/kg, i.p.) at two dose levels, viz ...
... Public Deposited ...
Therapeutic effect of vitamin B3 on hyperglycemia, oxidative stress and DNA damage in alloxan induced diabetic rat model.. ... This study reports the effects of niacin supplementation in alloxan induced diabetic rats divided into five groups. Diabetes ...
Abstract Alloxan and streptozotocin are widely used to induce experimental diabetes in animals. The mechanism of their action ... the source of their generation is different in the case of alloxan and streptozotocin. Alloxan and the product of its reduction ... Abstract Alloxan and streptozotocin are widely used to induce experimental diabetes in animals. The mechanism of their action ... The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas.. ...
... http ... Alloxan-induced Pancreatic Damage This section is compiled by Frank M. Painter, D.C.. Send all comments or additions to: Frankp ... METHODS: Alloxan-induced diabetic male Sprague-Dawley rats were randomly divided into 5 groups (10 rats per group) and treated ... In addition, rat islets were isolated, cultured, and exposed to alloxan in the presence or absence of genistein. The survival ...
Results Treatment of alloxan-induced diabetic rats with S. lehmbachii stem bark extract showed significant (p<0.01) reduction ... lehmbachii ethanol stem bark extract was evaluated in alloxan-induced diabetic rats at a dose of 100 mg/kg, 200 mg/kg, and 400 ... Treatment of alloxan-induced diabetic rats with S. lehmbachii stem bark extract showed significant (p,0.01) reduction in blood ... Liu Z, Li J, Zeng Z, Liu M, Wang M. The antidiabetic effects of cysteinyl metformin, a newly synthesized agent, in alloxan- and ...
The use of alloxan and streptozotocin in experimental diabetes models by Turkish Journal of Endocrinology and Metabolism; ... Selective uptake of alloxan by pancreatic B-cells. Biochem J 1982;208:513-5. (11.) Lenzen S, Mirzaie-Petri M. Inhibition of ... Role of Ca2+ in alloxan-induced pancreatic beta-cell damage. Biochim Biophys Acta 1994;1227:87-91. (15.) Golfman L, Dixon IM, ... The use of alloxan and streptozotocin in experimental diabetes models / Deneysel Diyabet Modellerinde Alloksan ve ...
Reversal of D- and A-Cell Insensitivity to Glucose in Alloxan-diabetic Dogs by Treatment with the Artificial Beta Cell ( ... In contrast, treatment of alloxan-diabetic dogs (N = 3) by a GCIIS for 24 h revived some responsiveness of the glucagon, ... Reversal of D- and A-Cell Insensitivity to Glucose in Alloxan-diabetic Dogs by Treatment with the Artificial Beta Cell ( ... Reversal of D- and A-Cell Insensitivity to Glucose in Alloxan-diabetic Dogs by Treatment with the Artificial Beta Cell ( ...
2) Alloxan diabetic rats (DB rats);. 3) Alloxan diabetics rats in which silica granulomatous inflammation was induced 8 days ... Adrenocortical system activity in alloxan-resistant and alloxan-susceptible Wistar rats. Journal of Diabetes Mellitus, 2, 165- ... Seven days after alloxan injection, daily urine was collected individually from each animal with special urine collectors, its ... As a result, the daily excretion of glucose in the group of alloxan diabetic rats selected for further study was 4.8 ± 0.5 g/ ...
Post-Heparin Lipolytic Activity and Tissue Lipoprotein Lipase Activity in the Alloxan-Diabetic Rat. R. S. Elkeles, E. Williams ... 1. Alloxan-diabetic rats showed raised plasma triglyceride levels and low adipose tissue lipoprotein lipase activity compared ... Post-Heparin Lipolytic Activity and Tissue Lipoprotein Lipase Activity in the Alloxan-Diabetic Rat ... Post-Heparin Lipolytic Activity and Tissue Lipoprotein Lipase Activity in the Alloxan-Diabetic Rat ...
Methods: Alloxan-induced diabetic rats? model was conducted to demonstrate the effects of the oral administration of Allium ... Furthermore, it?s clinical improvement and/or increased survival rates in alloxan-induced diabetic rats were evident and it was ... Hypoglycemic activity and regeneration of pancreatic beta-cells produced by Allium cepa in alloxan-induced diabetic rats. ...
Hypoglycemic activity in alloxan-induced diabetic Mus musculus (mouse) assessed as blood glucose level at 10 mg/kg, qd for 14 ...
Antidiabetic activity in alloxan-induced diabetic Rattus norvegicus albino Wistar (rat) model assessed as reduction in HDL ...
Alloxan cytotoxicity in vitro . Inhibition of rubidium ion pumping in pancreatic β -cells Biochem J (January, 1977) ... Contrasting effects of alloxan on islets and single mouse pancreatic β-cells Biochem J (November, 2000) ... Alloxan-induced luminol luminescence as a tool for investigating mechanisms of radical-mediated diabetogenicity Biochem J ( ... Except for the protection by NADH and NADPH, which may be due to a direct reaction with alloxan in the medium, the results ...
Administration of ethanol (95%) extract (45 mg/kg body wt/day for 28 days) of garlic (A.sativum) to alloxan induced diabetic ( ... Reduced nociceptive responses in mice with alloxan induced hyperglycemia after garlic (Allium sativum Linn.) treatment. ...
Corneal Lymphatics in Alloxan Vascularized Rabbit Eyes You will receive an email whenever this article is corrected, updated, ... Alloxan monohydrate was injected into the anterior chamber of normal rabbit eyes and resulted in extensive vascularization of ... H. BARRY COLLIN; Corneal Lymphatics in Alloxan Vascularized Rabbit Eyes. Invest. Ophthalmol. Vis. Sci. 1966;5(1):1-13. ...
alloxan induced diabetic rats. Am. J. Drug Discov. Dev., 2: 135-142.. CrossRef , Direct Link , Kim, J.S., J.B. Ju, C.W. Choi ... leaf extracts in alloxan-induced diabetic rats. Iran. J. Pharmacol. Ther., 4: 36-39.. Direct Link , Ahmida, M., 2011. ... Then after 5 days, 100 mg kg-1 of Alloxan monohydrate (Sigma®) was injected (IV). A week later, the second IVGTT was done and ... Alloxan monohydrate with 100 mg kg-1 in was injected intravenously for experimental group. After weighting, the blood samples ...
Superoxide dismutase-inhibitible reduction of cytochrome c by the alloxan radical. Implications for alloxan cytotoxicity. C C ... Superoxide dismutase-inhibitible reduction of cytochrome c by the alloxan radical. Implications for alloxan cytotoxicity ... Superoxide dismutase-inhibitible reduction of cytochrome c by the alloxan radical. Implications for alloxan cytotoxicity ... Superoxide dismutase-inhibitible reduction of cytochrome c by the alloxan radical. Implications for alloxan cytotoxicity ...
Sorbitol Pathway in the Ciliary Body in Relation to Accumulation of Amino Acids in the Aqueous Humor of Alloxan-Diabetic ... Sorbitol Pathway in the Ciliary Body in Relation to Accumulation of Amino Acids in the Aqueous Humor of Alloxan-Diabetic ... Corneal hydration control in normal and alloxan-induced diabetic rabbits.. Transport of Amino Acids into Intraocular Fluids and ... The Influence of Alloxan-Induced Diabetes on Müller Cell Contraction-Promoting Activities in Vitreous ...
MonohydrateHyperglycemiaExtractRabbitsGlucoseSingle injection of alloxanWISTAR RATSFruit in alloxan induced diabetic ratsActivities in alloxan induced diabeticGlibenclamideInjectionMice with alloxan induced0.05Toxic action of alloxanHypoglycemicMETHODSDiabetes in ratsDosesToxicity of alloxanReaction of alloxanEthanolSprague-DawleyStreptozotocinDoseAntihyperlipidemicInsulinPancreatic betaSigma AldrichInduceAqueousGlutathioneLiverExperimentalIntraperitoneallyRats were randomlyEffectVitroSuperoxide dismutaseExtractsManagement of diabetesBloodLipid Peroxidation
- Diabetes was induced in rats by administration of alloxan monohydrate. (hindawi.com)
- Alloxan monohydrate was injected into the anterior chamber of normal rabbit eyes and resulted in extensive vascularization of the corneae. (arvojournals.org)
- Alloxan monohydrate with 100 mg kg -1 in was injected intravenously for experimental group. (scialert.net)
- Buy Alloxan monohydrate (CAS ), a water soluble pyrimidine derivative & glucose analog. (ipicture.mobi)
- Join researchers using high quality Alloxan monohydrate. (ipicture.mobi)
- Diabetes mellitus was induced in 15 adult male rabbits, using 200 mg kg -1 of alloxan monohydrate as a single intraperitoneal injection. (scialert.net)
- A single injection of alloxan monohydrate (120 mg/kg, i.p.) prepared in normal saline was administered to produce diabetes in rats, after overnight fasting. (biomedcentral.com)
- For the experimental modeling of hyperglycemia, we used alloxan monohydrate, pre-dissolved in 0.9% solution of sodium chloride, which was then injected intraperitoneally once at a dose of 20 mg/100 g on an empty stomach. (rjdnmd.org)
- Hyperglycemia was induced by the injection of 150 mg/kg (i.p.) of alloxan monohydrate freshly dissolved in physiological saline. (tpcj.org)
- Diabetes was induced by injecting alloxan monohydrate 2% solution intra peritoneally in a dose of 150mg/kg body weight. (ijbcp.com)
- Therapeutic effect of vitamin B3 on hyperglycemia, oxidative stress and DNA damage in alloxan induced diabetic rat model. (nih.gov)
- In vivo high-dose (30 mg/kg per day) but not low-dose genistein significantly decreases weight loss, hyperglycemia, and islet cell loss in alloxan-induced diabetic rats, while increasing blood insulin levels and glucose tolerance. (chiro.org)
- NOPR: Reduced nociceptive responses in mice with alloxan induced hyperglycemia after garlic (Allium sativum Linn. (niscair.res.in)
- Administration of ethanol (95%) extract (45 mg/kg body wt/day for 28 days) of garlic ( A.sativum ) to alloxan induced diabetic (ALX-D) mice significantly lowered the serum glucose levels, nociceptive response in tail-flick, hotplate, allodynia, formalin test and relative thickness, weight of hind paw in formalin induced Paw oedema test, over 28 days, thus, showing the reversal trend in hyperglycemia and hyperalgesia compared to ALX-D mice. (niscair.res.in)
- In conclusion, chronic liraglutide treatment improves hyperglycemia by ameliorating beta cell mass and function in alloxan-induced diabetic mice. (nih.gov)
- Incidence of hyperglycemia in alloxan-untreated acatalasemic mice was as low as that in the normal mice. (elsevier.com)
- Rats with marked hyperglycemia were selected after a fortnight by administering alloxan (150 mg/kg) intraperitoneally. (ispub.com)
- The study aimed to investigate the lungs of pre-reproductive age rats under the influence of alloxan-induced hyperglycemia. (rjdnmd.org)
- Alloxan-induced hyperglycemia leads to the development of emphysematous changes in combination with restriction. (rjdnmd.org)
- The present study was carried out to investigate the effectiveness of three plant parts methanol extracts (orange peel extract, OPE, red onion skin powder, ROSE, and prickly pear extract, PPE) mixed with beef meatballs in modulating hyperglycemia using alloxan induced diabetic rats model. (sciencepublishinggroup.com)
- The aim of our study was to evaluate the effect of Artemisia absinthium ( A. absinthium ) ethanol extract on alloxan-induced diabetic rats. (springer.com)
- Diabetes was induced in the Swiss albino mice by injecting alloxan at the dose of 150 mg/kg body weight and aqueous extract of Momordica charantia fruits at doses of 100 mg/kg body weight and 250 mg/kg body weight was administered orally for three weeks. (hindawi.com)
- The extract was screened for hypoglycemic activity in alloxan-induced diabetic rats (120 mg/kg, i.p.) at two dose levels, viz. (ijpsonline.com)
- In this study, the antidiabetic and antihyperlipidemic potential of S. lehmbachii ethanol stem bark extract was evaluated in alloxan-induced diabetic rats at a dose of 100 mg/kg, 200 mg/kg, and 400 mg/kg p.o. daily for 21 days. (degruyter.com)
- The present study aimed to evaluate the protective effect of the ethanol leaves extract of C. scolymus in alloxan induced stress oxidant, hepatic-kidney dysfunction and histological changes in liver, kidney and pancreas of different experimental groups of rats. (biomedcentral.com)
- The anti-diabetic, antioxidant and anti-lipidemic activity of Salvadora persica leaf aqueous extract was tested in alloxan induced diabetic male rats. (alliedacademies.org)
- S. persica leaf aqueous extract has hypoglycaemic, antioxidant and hypolipidemic activity in alloxan induced diabetic male rats. (alliedacademies.org)
- Groups 2 - 5 were made diabetic using alloxan (150 mg/kg b.w in distil H 2 O). Except for groups 1 and 2, animals were gavaged at doses of 500 mg/kg b.w for the single dose of extract and 250 mg/kg for the combine extract treatment. (scirp.org)
- The methanolic extract of leaves of Turnera ulmifolia L was evaluated for its effect on blood glucose in alloxan-induced diabetic and euglycemic rats. (ac.ir)
- Extract at 400 mg/kg and glibenclamide significantly reduced blood glucose level in normal and alloxan-induced diabetic rats and raised the liver glycogen content significantly. (ac.ir)
- This study investigated the anti-diabetic effect of ethanolic bark extract of Khaya senegalensis in Alloxan-induced diabetic albino Wistar rats. (ijcmas.com)
- In conclusion, data generated from this study show that ethanolic bark extract of Khaya senegalensis possesses antihyperglycaemic activities in alloxan induced diabetic rats. (ijcmas.com)
- Bredleharm H. W. (2010) Effect of an Anti-diabetic extract of catharanthos on enzyme activities in Alloxan induced diabetic rats. (animalvetsci.org)
- the effect of the Nyctanthes arbor-tristis leaf extract (NALE) at doses 200mg/kg body weight and 400mg/kg body weight was evaluated for a period of 14 days on alloxan induced diabetic rabbits. (ajptr.com)
- This study investigated the effect of the ethanolic extract of Chrysophyllum albidum stem bark (EECA) on alloxan-induced diabetic rats. (notulaebiologicae.ro)
- The oral treatment with the aqueous extract of Momordica cymbalaria fruit (MC) (0.5 g/kg) for 6 weeks showed a significant antihyperglycemic as well as antihyperlipidemic effects in the alloxan-induced diabetic rats. (qxmd.com)
- The hydroethanolic extract of the leaves of Madhuca longifolia was administered orally to alloxan-induced diabetic rats and investigated for its antidiabetic properties. (ispub.com)
- The current investigation focuses on the serum insulin augmentation, anti-hyperglycemic and anti-hyperlipidemic property of aqueous fruit extract of Momordica Charantia on alloxan induced diabetes in male albino rats. (ijprs.com)
- To better understand the mechanisms associated with potential protective effect of P. oleracea extract against diabetes, alloxan-induced diabetic rats were used in this study. (biomedcentral.com)
- gavaged with P. oleracea extract daily [at 250 mg/kg] for 4 weeks and then daily IP injection of alloxan [at 75 mg/kg] for 5 days). (biomedcentral.com)
- The present study was undertaken to investigate the anti-diabetic capacity of a standardized hydromethanolic extract of Nerium oleander in alloxan induced diabetes in mice. (qxmd.com)
- The ethanolic leaf extract of Polyalthia suberosa (EEPS) was tested for its anti-diabetic activity by normoglycaemic plus glucose fed hyperglycaemic rats (NG-OGTT) method, and sub acute treatment methods in alloxan-induced diabetic rats. (pharmaresearchlibrary.com)
- In the present study the antidiabetic potential of methanol extract of cooked, dried and pulverized Stigma Maydis was assessed in alloxan-induced diabetic albino mice. (tpcj.org)
- Treatment of the alloxan-induced diabetic mice with the methanol extract of Stigma Maydis decreased the raised blood glucose levels in a dose-dependent manner. (tpcj.org)
- Test Pharmacological Effect of Ethanolic Extract of Eugenia polyantha Leaves as for Decreasing Glucose Level Activity on Mice Induced by Alloxan. (umy.ac.id)
- The study evaluated the ameliorative effects of Helianthus annuus leaf extract on nephrotoxicity, cardiac, and haematologic disorders in alloxan-induced hyperglycaemic rats. (sciendo.com)
- The extract and glibenclamide also ameliorated haematological disorders and kidney and cardiac damage induced by alloxan. (sciendo.com)
- The present study was designed to evaluate the ameliorative effects of hydromethanol leaf extract of H. annuus on nephrotoxicity, cardiac and haematologic disorders induced by alloxan in rats. (sciendo.com)
- Aim was to evaluate the ameliorative effect of Tithonia diversifolia leaves extract (TDE) in alloxan-induced diabetic mice. (cmu.ac.th)
- Akpovwehwee Akporhuarho Anigboro, Oghenetega Jonathan Avwioroko, Nyerhovwo John Tonukari, Brillantasia patula Aqueous Leaf Extract Averts Hyperglycermia, Lipid Peroxidation, and Alterations in Hematological Parameters in Alloxan-Induced Diabetic Rats, International Journal of Biomedical Science and Engineering . (ijbse.org)
- Adoum, O. A., Micheal, B. O., Mohammad, I. S. Phytochemicals and hypoglycaemic effect of methanol stem-bark extract of Ficus sycomorus Linn (Moraceae) on alloxan induced diabetic Wistar albino rats. (ijbse.org)
- Anigboro, A. A, Avwioroko, O. J., Ohwokevwo, O. A., Nzor, J. N. Phytochemical constituents, antidiabetic and ameliorative effects of Polyalthia longifiola leaf extract against alterations in hepatic and renal functions in alloxan-induced diabetic rats. (ijbse.org)
- The alloxan model of diabetes was first described in rabbits by Dunn, Sheehan and McLetchie in 1943. (wikipedia.org)
- Effect of ficus relegiosa on blood glucose and total lipid levels of normal and alloxan diabetic rabbits. (curehunter.com)
- 0.05) in alloxan treated rabbits. (curehunter.com)
- 0.05) on total lipid levels in normal as well as in alloxan -treated diabetic rabbits. (curehunter.com)
- Antidepressant-like effects of Brassica juncea L. We used alloxan to induce diabetes in rats and rabbits for screening the antidiabetic activity of test compounds. (ipicture.mobi)
- Effect of rate of injection of alloxan on development of diabetes in rabbits. (ipicture.mobi)
- In the present study, the hypoglycemic, antioxidant and hepatoprotective effects of Allium cepa (A.cepa) aqueous extracts on alloxan-induced diabetic rabbits was investigated. (scialert.net)
- There were also five rabbits which received neither alloxan nor A. cepa ( the negative control group). (scialert.net)
- The study was carried out to evaluate the effect of alloxan-induced diabetes on some oxidative stress markers in rabbits. (animalvetsci.org)
- Diabetes was induced in one of the groups, by intraperitonial administration of alloxan at a dosage of 150mg/kg body weight and the control rabbits were administered normal saline (0.9% NaCl). (animalvetsci.org)
- The results showed a significant decrease in mean body weight of the alloxan-induced diabetic and control rabbits pre and 14days post alloxan-induction. (animalvetsci.org)
- Enefe Ndidi Glory, Ebuehi Osaretin Albert, Antioxidant Enzymes and Lipid Peroxidation in Alloxan-Induced Diabetic Rabbits, Animal and Veterinary Sciences . (animalvetsci.org)
- Pre-diabetic Clinical Changes Induced by Low Doses of Alloxan-Streptozotocin Cocktail in Rabbits', Iranian Journal of Pathology , 9(2), pp. 197-112. (iranpath.org)
- Present investigation was aimed at studying pre-diabetic clinical changes induced by low doses of Alloxan-STZ cocktail in rabbits. (iranpath.org)
- Methods: New Zealand White rabbits, 1-1.5 kg body weight, were administered alloxan (@50 mg/kg b.w.) and STZ (@ 35mg/kg b.w.) cocktail, as single intravenous dose. (iranpath.org)
- Conclusion: Low dose Alloxan-STZ cocktail induced triphasic immediate response in rabbits. (iranpath.org)
- Mir SH, Darzi MM, Mir MS. Efficacy of Abroma augusta on biochemical and histomorphological features of Alloxan-induced diabetic rabbits. (iranpath.org)
- Clinical and pathomorphological effects of alloxan induced acute hypoglycaemia in rabbits. (iranpath.org)
- Alloxan is a toxic glucose analogue, which selectively destroys insulin-producing cells in the pancreas (that is beta cells) when administered to rodents and many other animal species. (wikipedia.org)
- Alloxan is selectively toxic to insulin-producing pancreatic beta cells because it preferentially accumulates in beta cells through uptake via the GLUT2 glucose transporter. (wikipedia.org)
- Furthermore, alloxan inhibits glucokinase, a SH-containing protein essential for insulin secretion induced by glucose. (wikipedia.org)
- Most studies have shown that alloxan is not toxic to the human beta-cell, even in very high doses, probably because of differing glucose uptake mechanisms in humans and rodents. (wikipedia.org)
- Four and 6 days after 3v, but not 4v, alloxan injection, alloxan-treated rats ate only 30% and their blood glucose area under the curve was only 28% of saline controls' after systemic 2-deoxy- d -glucose. (diabetesjournals.org)
- Because there have been conflicting studies implicating the hypothalamus ( 28 - 31 ) or hindbrain ( 18 , 32 , 33 ) as primary mediators of the CRR to glucose deficit, we also compared the effects of toxic doses of alloxan administered into the third ventricle (3v) versus the fourth ventricle (4v) on glucoprivic CRRs. (diabetesjournals.org)
- Using the isolated, perfused pancreas of dogs with moderate, untreated alloxan diabetes of 4 days duration, we found that 5 mM arginine (N = 4) and 5 mM calcium (N = 4) stimulated D- and A-cell secretion, whereas an increment in glucose from 1.3 to 11 mM (N = 4) had no effect on islet hormone secretion. (diabetesjournals.org)
- In the pancreas from untreated alloxan-diabetic dogs, acute infusion of large amounts of insulin (25 mU/ml) in vitro simultaneously with an elevation of perfusate glucose from 1.3 to 11 mM failed to restore the glucose sensitivity. (diabetesjournals.org)
- In contrast, treatment of alloxan-diabetic dogs (N = 3) by a GCIIS for 24 h revived some responsiveness of the glucagon, insulin, and somatostatin to glucose (1.3-11 mM) of the subsequently perfused pancreas. (diabetesjournals.org)
- We conclude that one of the possible mechanisms of the influence on silica granulomatous inflammation on the course of alloxan diabetes can be 1) a reduced LPO activity in liver cells at the lates stages of granulomagenesis process induced by a single dose of a suspension of silica microparticles and 2) a combined decrease in glucose production in the liver of alloxan diabetics rats. (scirp.org)
- The rats that were nondiabetic after initial dose of alloxan showed no impairments in oral glucose tolerance test and remained resistant to two subsequent doses of alloxan injected monohydratf 1 week interval. (ipicture.mobi)
- Alloxan-induced hyperglycemic mice were used to study the effects of P. eryngii on blood glucose, glycohemoglobin, insulin secretion, damaged pancreatic β-cells, total antioxidant status (TAOS), and hepatic glycogen in hyperglycemic mice. (begellhouse.com)
- We found that chronic liraglutide treatment improved glucose tolerance and insulin response to oral glucose load.Thirty-day treatment with liraglutide resulted in a 2-fold higher mass of pancreatic beta cells than that in vehicle group.Liraglutide reduced oxidative stress in pancreatic islet cells of alloxan-induced diabetic mice. (nih.gov)
- Hearts from normal and alloxan diabetic rats were perfused in vitro with a bicarbonate-buffered medium containing glucose. (rupress.org)
- The present work aimed to study the role of L- carnitine supplementation on glucose and lipid metabolism as well as to study its antioxidant effect in alloxan -induced diabetic rats . (bvsalud.org)
- Importance of the GLUT2 glucose transporter for pancreatic beta cell toxicity of alloxan. (notulaebiologicae.ro)
- Elsner M, Tiedge M, Guldbakke B, Munday R, Lenzen S. Importance of the GLUT2 glucose transporter for pancreatic beta cell toxicity of alloxan. (iranpath.org)
- Alloxan (150mg/kg) was used to induce diabetes in rats and the blood glucose levels were estimated by using glucometer. (crimsonpublishers.com)
- The present investigation was undertaken to study the antihyperglycemic effect of 'herbamed', a herbal formulation, on changes in blood glucose, plasma lipid profile and hepatic function test in alloxan-induced diabetic rats. (crimsonpublishers.com)
- We measured the glucose level using the Accu-Chek Advantage (Boehringer, Germany) at2, 12, and 24 hours after alloxan injection, and then weekly. (rjdnmd.org)
- To evaluate the effect of tamsulosin on blood glucose levels in euglycaemic rats and to investigate the effect of glibenclamide, tamsulosin and their combination on alloxan induced diabetic rats. (ijbcp.com)
- This study aimed to assess whether the triethylenetetramine (TETA) is impressed the plasma level of homocysteine (Hcy), total sialic acid (TSA) and cardiac troponin I (cTnI) as cardiovascular diseases risk factors, cystatin c (Cys c) and glucose along with histopathologic changes in alloxan induced diabetes mellitus in rabbit. (ac.ir)
- This study was conducted to evaluate the metabolic effect of eight-week administration of Niger Delta honey on the blood glucose, haematological parameters, body weight and glycosylated haemoglobin in alloxan-induced diabetic rats. (journalijbcrr.com)
- 0.05) improved blood cells and indices, body weight but caused marked decrease in blood glucose levels as well as glycosylated haemoglobin in alloxan diabetic rats. (journalijbcrr.com)
- Additionally, honey and glibenclamide combined may offer additional beneficial effects in alloxan - induced diabetes by synergic mechanisms on glucose metabolism and by further improvement in the vascular integrity. (journalijbcrr.com)
- To evaluate the pharmacodynamic interaction present study has been taken to study the effect of Nicorandil, a potassium channel opener on blood glucose level of alloxan induced diabetic rats and its pharmacodynamics interaction with Glibenclamide. (ijbcp.com)
- The purpose of this study is to find out the effect administration of sambiloto to blood glucose level on alloxan-induced diabetic rats. (umy.ac.id)
- This study showed that administration of sambiloto a significantly could be used to decrease blood glucose level on alloxan-induced diabetic rats. (umy.ac.id)
- IMSEAR at SEARO: Effect of Peanut (Arachis Hypogaea L.) On Fasting Blood Glucose And Hba1c in Alloxan Induced Diabetic Male Rats. (who.int)
- Treatment of animals with alloxan caused a significant increase (p≤0.05) in serum glucose concentration (49.47%) compared to normal control group. (sciencepublishinggroup.com)
- Diabetes was induced by a single injection of alloxan (120 mg/kg). (ac.ir)
- 19 dogs were given diabetes by a single injection of alloxan to knock out their beta cells. (2keto.com)
- Forty male Wistar rats were induced to diabetes with a single dose intraperitoneal injection (i.p.) of alloxan (150 mg/kg body weight (b.w. (biomedcentral.com)
- This study aims to examine the effects of flax and pumpkin powder seed mixture on alloxan induced diabetes in Wistar rats. (nih.gov)
- Albino male wistar rats were randomly assigned into 6 groups (2 euglycaemic and 4 alloxan induced diabetic rats groups). (ijbcp.com)
- Diabetes was confirmed after 3 days of single subcutaneous injection of alloxan (120 mg/kg) in albino Wistar rats. (jnsciences.org)
- Kameswara RB, Renuka SP, Rajasekhar MD, Nagaraju N, Appa Rao CH. Hypoglycemic activity of Terminalia pallida fruit in alloxan induced diabetic rats. (degruyter.com)
- The present study was aimed to evaluate the anti diabetic activity of polyherbal formulation containing some bitter plant constituents like neem, methi, karela fruit, amla , jamun seeds, kavat fruit in alloxan induced diabetic rats. (journalijar.com)
- Thus, from this study we concluded that Momordica charantia exhibited significant antihyperglycemic and rejuvenating capacity of kidney tissues activities in alloxan induced diabetic mice. (hindawi.com)
- Furthermore, it?s clinical improvement and/or increased survival rates in alloxan-induced diabetic rats were evident and it was found superior to glibenclamide. (omicsonline.org)
- Sixty diabetic mice were divided equally into 5 groups: the alloxan (AX)-induced hyperglycemic group, the AX and glibenclamide (GLI)−treated group, the AX and P. eryngii extracts (PEEs) 50−treated group (PEE 50 mg/kg), the AX and PEE100−treated group (PEE 100 mg/kg), and the AX and PEE200−treated group (PEE 200 mg/kg). (begellhouse.com)
- Study of influence of nicorandil on hypoglycemic action of glibenclamide in alloxan induced diabetic rats. (ijbcp.com)
- Two weeks after alloxan injection, 3v tanycyte destruction was reversed along with restoration of feeding and hyperglycemic responses to both systemic and hindbrain glucoprivation. (diabetesjournals.org)
- Diabetes was induced in five rat groups by a single intraperitoneal injection of alloxan (150 mg/kg body weight). (springer.com)
- Ten days after the last injection of tamoxifen, alloxan (Sigma-Aldrich) was administered intraperitoneally to the mice at 60 mg/kg body weight. (nih.gov)
- After induction of diabetes in rats [by alloxan ], L-carnitine was administered by IM daily injection of 100 mg/Kg body weight for 3 weeks. (bvsalud.org)
- Diabetic rats obtained by subcutaneous injection of alloxan in a dose of 120 mg/kg body weight. (who.int)
- In the present study, we investigated the role of TLR2 during the development of experimental deep dermatophytosis in normal mice and mice with alloxan-induced diabetes mellitus, an experimental model of diabetes that exhibits a delay in the clearance of the dermatophyte, Trichophyton mentagrophytes (Tm). (frontiersin.org)
- 0.05) reduced when compared to the alloxan induced diabetic rats. (journalcra.com)
- 0.05) and reversed the increased liver function parameters that occurred in alloxan-induced albino diabetic untreated rats, comparable to the effects of insulin. (who.int)
- The beta cell toxic action of alloxan is initiated by free radicals formed in this redox reaction. (wikipedia.org)
- Hypoglycemic activity of different fractions of Chrysophyllum albidum root bark in normal and alloxan diabetic rats. (notulaebiologicae.ro)
- Methods: Alloxan-induced diabetic rats? (omicsonline.org)
- Alloxan-induced diabetes in rats and the effects of black caraway (Carum carvi L.) oil on their body weight. (notulaebiologicae.ro)
- The current study was performed to evaluate the anti-diabetic action of metformin and ginseng in alloxan-induced diabetes in rats. (bibliomed.org)
- In conclusion, OPE, ROSE and PPPE have ameliorated the effect of alloxan induced diabetes in rats. (sciencepublishinggroup.com)
- Alloxan is, however, toxic to the liver and the kidneys in high doses. (wikipedia.org)
- To do this, we used alloxan, which pharmacologically inhibits GK activity at low doses ( 19 , 20 ), but induces cell death at higher concentrations, presumably through the production of reactive oxygen radicals ( 21 , 22 ). (diabetesjournals.org)
- These were noted with both low and high doses of alloxan in rats. (ipicture.mobi)
- Quail eggs were administered to thirty six (36) alloxan induced diabetic rats, which were divided into nine (9) different groups of four (4) rats each per group at varied doses for a duration of seven (7), fourteen (14) and twenty one (21) days. (alliedacademies.org)
- The effects of different doses (200 mg/bw, and 300/bw) of both water and methanol extracts of P. americana seed on alloxan-induced diabetic albino rats were compared with those of a reference drug, insulin. (who.int)
- mediate the diabetogenic toxicity of alloxan. (portlandpress.com)
- Cytochrome c was reduced when superoxide was generated from xanthine oxidase in the presence of alloxan, and by the reaction of alloxan and with reduced glutathione. (biochemj.org)
- Results: Alloxan, which was a drug that caused diabetes mellitus, mostly generated hydrogen peroxide by the reaction of alloxan and reduced glutathione, in vitro. (elsevier.com)
- The anti-diabetic and biochemical effects of both the water and ethanol extracts of Persea americana (avocado pear) seed on alloxan-induced diabetic albino rats were investigated. (who.int)
- Alloxan-induced diabetic male Sprague-Dawley rats were randomly divided into 5 groups (10 rats per group) and treated with saline, vehicle, and 3 different dosages of genistein by daily gavage. (chiro.org)
- Result showed decreased immunoreactivity to GRP in the sub mucosal neurons of the stomach and small intestine in alloxan-diabetic Sprague Dawley rats. (thescipub.com)
- The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas. (omicsonline.org)
- Abstract Alloxan and streptozotocin are widely used to induce experimental diabetes in animals. (omicsonline.org)
- The cytotoxic action of both these diabetogenic agents is mediated by reactive oxygen species, however, the source of their generation is different in the case of alloxan and streptozotocin. (omicsonline.org)
- The use of alloxan and streptozotocin in experimental diabetes models / Deneysel Diyabet Modellerinde Alloksan ve Streptozotosin Kullanimi. (thefreelibrary.com)
- Background & Objectives: Alloxan & streptozotocin are used for inducing diabetic models. (iranpath.org)
- Lenzen S. The mechanisms of alloxan- and streptozotocin-induced diabetes. (iranpath.org)
- Induction of alloxan/streptozotocin diabetes in dogs: A revised experimental technique. (iranpath.org)
- Hyperglycaemia was induced by administration of a single dose (150 mg/kg i.p) of alloxan. (projecttopics.org)
- This study was undertaken to evaluate the anti-hyperglycemic and antihyperlipidemic effects of cornelian cherry (Cornus mas L., CM) fruits - that are rich in anthocyanins and known to have medicinal properties- in alloxan-induced diabetic rats. (ac.ir)
- The aim of this study was to investigate the antidiabetic, antihyperlipidemic and antioxidant activities of fenugreek in alloxan induced diabetic rats. (jnsciences.org)
- This causes an insulin-dependent diabetes mellitus (called "alloxan diabetes") in these animals, with characteristics similar to type 1 diabetes in humans. (wikipedia.org)
- Because it selectively kills the insulin-producing beta-cells found in the pancreas, alloxan is used to induce diabetes in laboratory animals. (wikipedia.org)
- In vitro experiments reveal that genistein improves islet cell survival and proliferation and facilitates insulin production after alloxan injury. (chiro.org)
- To test the effect of insulin treatment on the pharmacokinetics of metformin in rats with diabetes mellitus induced by alloxan (DMIA rats). (ualberta.ca)
- Postoperative changes in the lipid content of the liver, placenta and embryo of normal, alloxan diabetic and insulin-treated rats]. (semanticscholar.org)
- Liraglutide improves pancreatic Beta cell mass and function in alloxan-induced diabetic mice. (nih.gov)
- Here we clarify the effects of the human GLP-1 analog liraglutide on beta cell fate and function by using an inducible Cre/loxP-based pancreatic beta cell tracing system and alloxan-induced diabetic mice. (nih.gov)
- Drugs and chemicals used such as Alloxan, metformin, Tris-HCl buffer and sodium chloride were obtained from Sigma-Aldrich (St. Louis, MO, USA. (crimsonpublishers.com)
- Forty male albino rats were used in this work, ten rats were left without any treatment and kept as a control, the remaining thirty rats were injected with alloxan to induce diabetes and then divided into three equal groups, the first group was kept without any treatment during period of the experiment, the second one treated with metformin (300 mg/kg B.Wt. (bibliomed.org)
- This study was, therefore, designed to evaluate the anti-diabetic potential of aqueous leaf extracts of Rhoicissus tridentata in alloxan induced diabetic mice. (ac.ke)
- In addition, alloxan has a high affinity to SH-containing cellular compounds and, as a result, reduces glutathione content. (wikipedia.org)
- The purpose of the present work was to investigate the activity of lipid peroxidation processes in the liver of rats with silica-induced granulomatous inflammation, alloxan diabetes and their combination. (scirp.org)
- This study evaluated the effects of alloxan on the kinetics properties of the δ-aminolevulinate dehydratase (δ-ALA-D) using mouse liver homogenates. (springer.com)
- Rusina I.M., Makarchikov A.F., Makar E.A., Kubyshin V.L., Nucleoside-5'-triphosphate hydrolysis in the liver and kidney of rats with chronic alloxan diabetes, Biomeditsinskaya khimiya, 2006, vol: 52(4), 364-369. (msk.ru)
- It also showed a beneficial effect on the lipid profile and liver function test in alloxan induced diabetic rats. (crimsonpublishers.com)
- Despite the known effects of alloxan in models of experimental diabetes, there are no data in the literature demonstrating the effects of alloxan on the kinetics properties of the δ-ALA-D. The results showed that alloxan (1.25-20 μM) caused a concentration-dependent inhibition of hepatic δ-ALA-D activity. (springer.com)
- Experimental diabetes was induced by alloxan (120 mg/kg, s.c.) in rats. (ac.ir)
- In addition to basal diet, animals of DC-A received alloxan intraperitoneally only on the first day of the study. (who.int)
- Normal and alloxan-induced diabetic rats were randomly divided into groups and treated with 100-200 mg/kg EECA for 7, 14 and 28 days respectively. (notulaebiologicae.ro)
- Also, in combination verapamil interfere with the hypoglycaemic effect of the beforementioned oral hypoglycaemic drugs in normal fasted and alloxan diabetic rats. (who.int)
- There is no report available in the literature for the anti-diabetic effect of 'herbamed' in alloxan-induced diabetic rats. (crimsonpublishers.com)
- The effect of alloxan-induced diabetes on anti-nociception and on the development of morphine tolerance and dependence in rats', Iranian Journal of Pharmaceutical Research , Volume 3(Supplement 1), pp. 51-51. (ac.ir)
- These results were confirmed by the histopathological assessments which showed marked improvement of the destructive effect on pancreatic islet cells induced by alloxan. (biomedcentral.com)
- The anti-diabetic effect and antioxidant activity of ethyl acetate (EtOAc) of Phaleria macrocarpa (PM) was investigated in alloxan-induced diabetic rats. (uii.ac.id)
- The result of the present study concluded that the diabetic effect of EtOAc fraction of PM against alloxan-induced diabetic rats is mediated either by preventing the decline of hepatic antioxidant status or due to its indirect radical scavenging capacity. (uii.ac.id)
- Yousif Elhassaneen, Samia Goarge, Ryeaan Sayed, Mayada Younis, Onion, Orange and Prickly Pear Peel Extracts Mixed with Beef Meatballs Ameliorate the Effect of Alloxan Induced Diabetic Rats, American Journal of Pharmacology and Phytotherapy . (sciencepublishinggroup.com)
- Therefore, this work showed that the inhibition of hepatic δ-ALA-D activity can be obtained in vitro at low micromolar levels of alloxan, and can also be prevented by reducing agents. (springer.com)
- Superoxide dismutase-inhibitible reduction of cytochrome c by the alloxan radical. (biochemj.org)
- This indicates that the superoxide dismutase-inhibitible cytochrome c reduction was mainly due to a direct reaction with the alloxan radical, and implies that other reactions that are inhibited by superoxide dismutase could be due to either alloxan radicals or superoxide. (biochemj.org)
- AlarconA FJ, Roman RR, Flores S JL, Aguirre GF (2002) Investigation on the hypoglycaemic effects of extracts of four Mexican medicinal plants in normal and alloxan-diabetic mice. (springer.com)
- Okra Peel „OP‟ and Okra Seed „OS‟) of Ex-maradi Okra fruit variety in the management of diabetes mellitus in alloxan induced diabetic rats. (ajol.info)
- The objective of this study was to ascertain the scientific basis for the use of the plant in the management of diabetes using alloxan -induced diabetic rats. (ispub.com)
- This study was aimed at determining the dietary effects of quail eggs on blood sugar and lipid profile of alloxan induced diabetic rats. (alliedacademies.org)
- Conclusion: These results indicate that low catalase activity in the blood is associated with the diabetes mellitus caused by alloxan administration. (elsevier.com)
- Verapamil alone, increased blood sugar level in normal fasted and alloxan diabetic rats. (who.int)
- Culminating a depletion of SOD activity, the altered activity of plasma (or brain) catalase and increased lipid peroxidation is due to the oxidative stress induced by the diabetic condition, hence the present study indicate that alloxan - induced diabetic potentiated oxidative stress in a short term duration. (animalvetsci.org)
- Fatty acid composition and lipid peroxidation in rat brain microsomes were studied under conditions of alloxan diabetes. (msk.ru)
- Martikian A.R., Vartanian G.S., Karagezian K.G., Fatty acid composition and lipid peroxidation in brain microsomes of albino rats with alloxan diabetes, Voprosy meditsinskoi khimii, 1985, vol: 31(3), 86-87. (msk.ru)