AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and Equipment
AlloxanNinhydrinDiabetes Mellitus, ExperimentalTrigonellaIslets of LangerhansBlood GlucoseGlycosuriaStreptozocin
Alloxan
Ninhydrin
2,2-Dihydroxy-1H-indene-1,3-(2H)-dione. Reagent toxic to skin and mucus membranes. It is used in chemical assay for peptide bonds, i.e., protein determinations and has radiosensitizing properties.
Diabetes Mellitus, Experimental
Diabetes mellitus induced experimentally by administration of various diabetogenic agents or by PANCREATECTOMY.
Trigonella
A plant genus of the family FABACEAE.
Islets of Langerhans
Irregular microscopic structures consisting of cords of endocrine cells that are scattered throughout the PANCREAS among the exocrine acini. Each islet is surrounded by connective tissue fibers and penetrated by a network of capillaries. There are four major cell types. The most abundant beta cells (50-80%) secrete INSULIN. Alpha cells (5-20%) secrete GLUCAGON. PP cells (10-35%) secrete PANCREATIC POLYPEPTIDE. Delta cells (~5%) secrete SOMATOSTATIN.
Blood Glucose
Glucose in blood.
Glycosuria
The appearance of an abnormally large amount of GLUCOSE in the urine, such as more than 500 mg/day in adults. It can be due to HYPERGLYCEMIA or genetic defects in renal reabsorption (RENAL GLYCOSURIA).
Streptozocin
An antibiotic that is produced by Stretomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.

Accelerated intimal hyperplasia and increased endogenous inhibitors for NO synthesis in rabbits with alloxan-induced hyperglycaemia. (1/243)

1. We examined whether endogenous inhibitors of NO synthesis are involved in the augmentation of intimal hyperplasia in rabbits with hyperglycaemia induced by alloxan. 2. Four weeks after the endothelial denudation of carotid artery which had been performed 12 weeks after alloxan, the intimal hyperplasia was greatly augmented with hyperglycaemia. The degree of hyperplasia was assessed using three different parameters of histopathological findings as well as changes in luminal area and intima: media ratio. 3. There were positive and significant correlations between intima:media ratio, plasma glucose, and concentrations of N(G)-monomethyl-L-arginine (L-NMMA) and N(G), N(G)-dimethyl-L-arginine (ADMA) in endothelial cells, that is, the intima:media ratio became greater as plasma glucose and endothelial L-NMMA and ADMA were increased. Furthermore, endothelial L-NMMA and ADMA were increased in proportion to the increase in plasma glucose. 4. In contrast, there were inverse and significant correlations between cyclic GMP production by carotid artery strips with endothelium and plasma glucose, between cyclic GMP production and endothelial L-NMMA and ADMA, and between the intima:media ratio and cyclic GMP production. 5. Exogenously applied L-NMMA and ADMA inhibited cyclic GMP production in a concentration-dependent manner. IC50 values were determined to be 12.1 microM for the former and 26.2 microM for the latter. The cyclic GMP production was abolished after the deliberate removal of endothelium from the artery strips. 6. These results suggest that the augmentation of intimal hyperplasia with hyperglycaemia is closely related to increased accumulation of L-NMMA and ADMA with hyperglycaemia, which would result in an accelerated reduction in NO production/release by endothelial cells.  (+info)

Alloxan in vivo does not only exert deleterious effects on pancreatic B cells. (2/243)

The aim of the experiment was to investigate the mechanism of harmful alloxan action in vivo. 75 mg/kg b.w. of this diabetogenic agent were administered to fasting rats. Two minutes later the animals were decapitated. It was observed that alloxan caused a distinct rise in blood insulin and glucose levels with a concomitant drop of free fatty acids. The amount of sulfhydryl groups in the liver of alloxan-treated rats was decreased and glutathione peroxidase activity was substantially higher. These results indicate that some changes observed in alloxan-induced diabetes can not only be the consequence of B cells damage by alloxan but may also be the result of its direct influence on other tissues. It was also observed that glucose given 20 min before alloxan injection only partially protected against the deleterious effects of alloxan.  (+info)

Intercalated duct cells in the chicken pancreatic islet with special reference to the alloxan administration. (3/243)

The intercalated duct cells were observed in the A and B islets of the chicken pancreas. These cells adhered with each other by intercellular junctional complexes at the apical side. They had many microvilli projecting into the lumen. Abluminally, they displayed extended slender cytoplasmic processes between islet endocrine cells. Administration of alloxan resulted to denser cytoplasm and a more prominent thickening of cytoplasmic processes of the intercalated duct cells, although the blood glucose levels did not show appreciable changes by the treatment. The intercalated duct epithelial cells appeared clearly as stellate cells. The lysosomes increased in size and number with passage of time after alloxan administration. The present findings may suggest that intercalated ducts are not only anatomically important as a structure passing through the islet but also play physiologically by protecting the islet endocrine cells.  (+info)

Reduced coronary NO production in conscious dogs after the development of alloxan-induced diabetes. (4/243)

The role of nitric oxide (NO) in the control of coronary blood flow (CBF) during the development of diabetes is unknown. To study this, mongrel dogs were chronically instrumented using sterile techniques for measurements of systemic hemodynamics and CBF. With heart rate controlled (150 beats/min), veratrine (1-10 micrograms/kg) caused dose-dependent increases in CBF; e.g., 5 mirograms/kg of veratrine increased CBF by 57 +/- 7% from 41 +/- 1.3 ml/min (P < 0.05). The dogs developed diabetes 4-5 wk after injection of alloxan (40-60 mg/kg iv, blood glucose levels were 384 +/- 18 mg/dl). After diabetes the same doses of veratrine caused smaller increases in CBF; i.e., 5 micrograms/kg of veratrine increased CBF by 32 +/- 2% (P < 0.05 compared with control) from 28 +/- 4 ml/min. ACh- and adenosine-induced coronary vasodilation were reduced after diabetes as well. In anesthetized dogs after diabetes, vagal stimulation caused smaller increases in CBF. ACh and bradykinin caused smaller increases in NO(-)(2) production in coronary microvessels from diabetic dogs. Furthermore, despite the fact that mRNA for endothelial cell NO synthase from the aorta was increased twofold with the use of Northern blotting, the protein for aortic endothelial constitutive NO synthase was reduced by 66% after diabetes, as determined by Western blotting. Our results indicate that the NO-dependent coronary vasodilation by the Bezold-Jarisch reflex is impaired in conscious dogs after diabetes. The mechanism responsible for the impaired endothelium-dependent coronary vasodilation is most likely the decreased release of NO from the endothelium.  (+info)

Supplementation of N-acetylcysteine inhibits NFkappaB activation and protects against alloxan-induced diabetes in CD-1 mice. (5/243)

Reactive oxygen species (ROS) are involved in the destruction of pancreatic beta cells and the development of insulin-dependent diabetes mellitus (IDDM). However, the cellular mechanism responsible for beta cell death is still unclear. We hypothesize that activation of NFkappaB by ROS is the key cellular signal in initiating a cascade of events leading to beta cell death. Thus, enhancement of pancreatic GSH, a known antioxidant and key regulator of NF-kappaB, should protect against IDDM. Weanling CD1 mice (n=5) were injected with alloxan (50 mg/kg i.v.) to induce IDDM. Using EPR spin trapping techniques, we demonstrated that alloxan generated ROS in the pancreas 15 min after administration. Activation of NFkappaB in pancreatic nuclear extracts was observed 30 min after alloxan injection, as assessed by an electrophoretic mobility shift assay. Fasting blood glucose levels were monitored for 14 days. Supplementation with N-acetylcysteine (NAC, 500 mg/kg), a GSH precursor, inhibited alloxan-induced NFkappaB activation and reduced hyperglycemia. Thus, NFkappaB activation by ROS may initiate a sequence of events leading to IDDM. Inhibition of NF-kappaB activation by NAC attenuated the severity of IDDM. This research will contribute to the understanding of the etiology of IDDM and may lead to the development of better strategies for disease prevention.  (+info)

Lipolysis induced by alloxan in rat adipocytes is not inhibited by insulin. (6/243)

Isolated rat adipocytes were incubated with adrenaline, adrenaline plus insulin, alloxan or alloxan plus insulin. Glycerol release was taken as a measure of lipolysis. It was observed that alloxan in the concentration of 3, 10 and 20 mmol/l intensifies lipolysis in adipocytes in the absence of adrenaline. Insulin (10(-6) mol/l) treatment of cells did not inhibit lipolysis caused by this compound, but significantly restricted lipolysis induced by adrenaline (10(-6) mol/l). It was also shown that alloxan in the concentration of 3 and 10 mmol/l intensified lipolysis stimulated by adrenaline (10(-6) mol/l). Addition of 20 mmol/l of alloxan strongly inhibited glycerol release in the presence of adrenaline. The results presented here clearly indicate that the action of alloxan concerns cells of the white adipose tissue.  (+info)

Resistance of ALR/Lt islets to free radical-mediated diabetogenic stress is inherited as a dominant trait. (7/243)

ALS/Lt and ALR/Lt are inbred mouse strains selected for susceptibility and resistance to alloxan (AL)-induced diabetes. Within 24-h after AL administration in vivo, ALS/Lt islets were distinguished from ALR/Lt islets by more extensive necrotic changes. Within 7 days post-AL, ALS/Lt mice exhibited hyperglycemia and hypoinsulinemia, whereas ALR/Lt mice maintained normal plasma insulin and glucose levels. We have recently shown that resistance in ALR/Lt correlated with constitutively elevated systemic (and pancreatic) free radical defense status. In the present report, we examined whether ability to detoxify free radical stress extended to the level of ALR/Lt pancreatic islets. Cultured ALS/Lt islets exposed for 5 min to increasing (0-3 mmol/l) AL concentrations in vitro exhibited an 80% decline in numbers of intact islets after a subsequent 6-day culture period, as well as a 75% reduction in islet insulin content and a 94% decrease in glucose-stimulated insulin secretory capacity. In contrast, ALR/Lt islets remained viable and retained glucose-stimulated insulin secretory capacity as well as normal insulin content. This ALR/Lt islet resistance extended to hydrogen peroxide, a free radical generator whose entry into beta-cells is not dependent on glucose transporters. The elevated antioxidant defenses previously found in ALR/Lt pancreas were extended to isolated islets, which exhibited significantly higher glutathione and Cu-Zn superoxide dismutase 1 levels compared with ALS/Lt islets. A dominant genetic trait from ALR/Lt controlling this unusual AL resistance was indicated by the finding that reciprocal F1 mice of both sexes were resistant to AL administration in vivo. A backcross to ALS/Lt showed 1:1 segregation for susceptibility/resistance, indicative of a single gene controlling the phenotype. In conclusion, the ALR/Lt mouse may provide important insight into genetic mechanisms capable of rendering islets strongly resistant to free radical-mediated damage.  (+info)

Protective mechanism of glucose against alloxan-induced beta-cell damage: pivotal role of ATP. (8/243)

Glucose prevents the development of diabetes induced by alloxan. In the present study, the protective mechanism of glucose against alloxan-induced beta-cell damage was investigated using HIT-T 15 cell, a Syrian hamster transformed beta-cell line. Alloxan caused beta-cell damages with DNA fragmentation, inhibition of glucose-stimulated insulin release, and decrease of cellular ATP level, but all of these beta-cell damages by alloxan were prevented by the presence of 20 mM glucose. Oligomycin, a specific inhibitor of ATP synthase, completely abolished the protective effects of glucose against alloxan-induced cell damage. Furthermore, treatment of nuclei isolated from HIT-T15 cells with ATP significantly prevented the DNA fragmentation induced by Ca2+. The results indicate that ATP produced during glucose metabolism plays a pivotal role in the protection of glucose against alloxan-induced beta-cell damage.  (+info)

Superoxide dismutase-inhibitible reduction of cytochrome c by the alloxan radical. Implications for alloxan cytotoxicity |...Superoxide dismutase-inhibitible reduction of cytochrome c by the alloxan radical. Implications for alloxan cytotoxicity |...
Cytochrome c was reduced when superoxide was generated from xanthine oxidase in the presence of alloxan, and by the reaction of alloxan and with reduced glutathione. In each case, most of the reduction was inhibited by superoxide dismutase, but considerably more enzyme was required than with superoxide alone. This indicates that the superoxide dismutase-inhibitible cytochrome c reduction was mainly due to a direct reaction with the alloxan radical, and implies that other reactions that are inhibited by superoxide dismutase could be due to either alloxan radicals or superoxide.. ...
http://www.biochemj.org/content/207/3/609
Effects of Diabetes Mellitus Induced by Alloxan on the Pharmacokinetics of Metformin in Rats: Restoration of Pharmacokinetic...Effects of Diabetes Mellitus Induced by Alloxan on the Pharmacokinetics of Metformin in Rats: Restoration of Pharmacokinetic...
Effects of Diabetes Mellitus Induced by Alloxan on the Pharmacokinetics of Metformin in Rats: Restoration of Pharmacokinetic Parameters to the Control State by Insulin Treatment
https://journals.library.ualberta.ca/jpps/index.php/jpps/article/view/1608
Activation of a novel non-selective cation channel by alloxan and H2O2 in the rat insulin-secreting cell line CRI-G1<...
TY - JOUR. T1 - Activation of a novel non-selective cation channel by alloxan and H2O2 in the rat insulin-secreting cell line CRI-G1. AU - Herson, P. S.. AU - Ashford, M. L.. PY - 1997/5/15. Y1 - 1997/5/15. N2 - 1. Alloxan and its auto-oxidation product hydrogen peroxide (H2O2) irreversibly depolarize insulinoma cells by opening a non-selective cation channel. The channel opened is characterized by a linear current-voltage relation with a conductance of approximately 70 pS and very slow kinetics (of the order of seconds). 2. Cells are protected against the alloxan-induced channel opening and consequent cell depolarization by the presence of H2O2 and hydroxyl radical scavengers. 3. The free radical-activated non-selective cation channel is not operative in isolated patches but can be activated by the application of beta-NAD+ to the cytoplasmic aspect of the membrane.. AB - 1. Alloxan and its auto-oxidation product hydrogen peroxide (H2O2) irreversibly depolarize insulinoma cells by opening a ...
https://discovery.dundee.ac.uk/en/publications/activation-of-a-novel-non-selective-cation-channel-by-alloxan-and
THE EFFECT OF INSULIN, ALLOXAN DIABETES, AND ANOXIA ON THE ULTRASTRUCTURE OF THE RAT HEART | Journal of Cell Biology |...THE EFFECT OF INSULIN, ALLOXAN DIABETES, AND ANOXIA ON THE ULTRASTRUCTURE OF THE RAT HEART | Journal of Cell Biology |...
Hearts from normal and alloxan diabetic rats were perfused in vitro with a bicarbonate-buffered medium containing glucose. Transport of glucose through the cell membrane was stimulated with insulin or by induction of anaerobiosis. The organs were rapidly fixed and examined by electron microscopy. Transport stimulation was not associated with any increase in the number of sarcolemmal invaginations or subsarcolemmal cytoplasmic vesicles. It was concluded that glucose transport and the effects of insulin or anoxia do not involve pinocytosis. The relationship of pinocytosis to glucose transport is discussed. The appearance of numerous lipid inclusions at the Z line level of the sarcomeres in the diabetic and anoxic myocardia is described. ...
https://rupress.org/jcb/article/15/3/509/16166/THE-EFFECT-OF-INSULIN-ALLOXAN-DIABETES-AND-ANOXIA
Alloxan Monohydrate Manufacturers, Suppliers, Exporters, Dealers in Sangli, IndiaAlloxan Monohydrate Manufacturers, Suppliers, Exporters, Dealers in Sangli, India
Get Information of Alloxan Monohydrate Manufacturers, Suppliers, Dealers, Exporters, Traders, Producers, Wholesalers, Alloxan Monohydrate Companies in Sangli, India
http://www.sanglibusiness.com/Products/SearchResult?ProductName=alloxan-monohydrate
Postoperative changes in the lipid content of the liver, placenta and embryo of normal, alloxan diabetic and insulin-treated...Postoperative changes in the lipid content of the liver, placenta and embryo of normal, alloxan diabetic and insulin-treated...
Semantic Scholar extracted view of [Postoperative changes in the lipid content of the liver, placenta and embryo of normal, alloxan diabetic and insulin-treated rats]. by W Haude et al.
https://www.semanticscholar.org/paper/Postoperative-changes-in-the-lipid-content-of-the-Haude-Goetze/203712adc107927f867480a1f4e5b235b9b0286a
Fatty acid composition and lipid peroxidation in brain microsomes of albino rats with alloxan diabetesFatty acid composition and lipid peroxidation in brain microsomes of albino rats with alloxan diabetes
Abstract: Fatty acid composition and lipid peroxidation in rat brain microsomes were studied under conditions of alloxan diabetes. The data obtained indicate significant differences in the content of unsaturated fatty acids and also a slight activation of lipid peroxidation in the pathological state studied ...
http://pbmc.ibmc.msk.ru/index.php/en/article/PBMC-1985-31-3-86-en
Internet Scientific Publications
The present work has detected the antidiabetic effect of the MLE in alloxan-induced diabetic rats. Alloxan causes a massive reduction in insulin release, by the destruction of the beta cells of the islets of Langerhans and inducing hyperglycemia [17]. MLE lowered the blood glucose levels in normal rats within and in glucose loaded animals, in which the pancreatic cells are still fully intact. Hydroethanolic extract of the drug might be able to stimulate insulin secretion in normal rats, as did glibenclamide. Thus the results obtained show that oral administration of MLE produces a significant decrease in blood glucose levels in alloxan diabetic rats on both acute and long term administration. In contrast, the significant increase in plasma glucose levels of untreated diabetic rats may be due to progressive severity of untreated diabetes. The most common lipid abnormalities in diabetes are hypertriglyceridemia and hypercholesterolemia [18]. Hypertriglyceridemia is also associated in metabolic ...
http://ispub.com/IJPHARM/6/2/5614
IJPBS Article- DIFFERENTIAL EFFECTS OF ALLOXAN ON DIFFERENT BLOOD PARAMETERS IN DIABETEC INDUCED MALE WISTAR RATSIJPBS Article- DIFFERENTIAL EFFECTS OF ALLOXAN ON DIFFERENT BLOOD PARAMETERS IN DIABETEC INDUCED MALE WISTAR RATS
Archives issue of International Journal of Pharma and Bio Sciences which aims to cover the latest outstanding developments in the field of pharmaceutical and biological sciences
http://www.ijpbs.net/details.php?article=4112
Hypoglycemic Activity And Regeneration Of Pancreatic Beta-cells Produced By Allium Cepa In Alloxan-induced Diabetic RatsHypoglycemic Activity And Regeneration Of Pancreatic Beta-cells Produced By Allium Cepa In Alloxan-induced Diabetic Rats
Background: Diabetes mellitus is a chronic disease caused by inherited and/or acquired deficiency in production of insulin by the pancreas, or by ineffectivene...
https://www.omicsonline.org/proceedings/hypoglycemic-activity-and-regeneration-of-pancreatic-betacells-produced-by-allium-cepa-in-alloxaninduced-diabetic-rats-24957.html
The use of alloxan and streptozotocin in experimental diabetes models / Deneysel Diyabet Modellerinde Alloksan ve...The use of alloxan and streptozotocin in experimental diabetes models / Deneysel Diyabet Modellerinde Alloksan ve...
Free Online Library: The use of alloxan and streptozotocin in experimental diabetes models by Turkish Journal of Endocrinology and Metabolism; Health, general Diabetes Diabetes mellitus Pyrimidines Streptozocin
https://www.thefreelibrary.com/The+use+of+alloxan+and+streptozotocin+in+experimental+diabetes+models+...-a0349741337
The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas.The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas.
Abstract Alloxan and streptozotocin are widely used to induce experimental diabetes in animals. The mechanism of their action in B cells of the pancreas has been intensively invest..
https://www.omicsonline.org/references/the-mechanism-of-alloxan-and-streptozotocin-action-in-b-cells-of-the-rat-pancreas-1319105.html
Blog of Pure Puer Tea » Oral administration of puerh tea polysaccharides lowers blood glucose levels and enhances antioxidant...
J Food Sci. 2012 Nov;77(11):H246-52. doi: 10.1111/j.1750-3841.2012.02950.x. Epub 2012 Oct 11.. Oral administration of puerh tea polysaccharides lowers blood glucose levels and enhances antioxidant status in alloxan-induced diabetic mice.. By Xu P, Chen H, Wang Y, Hochstetter D, Zhou T, www.ncbi.nlm.nih.gov. Author information. Department of Tea Science, Zhejiang University, 866 Yuhangtang Rd., Hangzhou 310058, China.. Abstract. The polysaccharides, named puerh tea polysaccharides (PTPS), were isolated from puerh tea. Physicochemical characteristics, hypoglycemic and antioxidant effects of PTPS in alloxan-induced diabetic mice were investigated. PTPS was found to be a kind of acid heteropolysaccharides conjugate, but the physicochemical characteristics of which were different from the polysaccharides from other kinds of teas in literature. Meanwhile, daily administration of PTPS (40 mg/kg BW) could significantly lower the blood glucose levels, which was not different (P , 0.05) from the effects ...
https://purepuer.com/blog/?page_id=3977
Apitherapy News: Propolis May Protect Against Damage Caused by DiabetesApitherapy News: Propolis May Protect Against Damage Caused by Diabetes
Administration of propolis to diabetic mice resulted in a significant increase of body weight, haematological and immunological parameters of blood as well as 100% survival of diabetic mice. Alloxan-injected mice showed a marked increase in oxidative stress in liver and kidney homogenate, as determined by lipid peroxidation. Histopathological observation of the liver sections of alloxan-induced diabetic mice showed several lesions including cellular vacuolization, cytoplasmic eosinophilia and lymphocyte infiltrations, but with individual variability.Treatment of diabetic mice with propolis extracts results in decreased number of vacuolized cells and degree of vacuolization; propolis treatment improve the impairment of fatty acid metabolism in diabetes. Renal histology showed corpuscular, tubular and interstitial changes in alloxan-induced diabetic mice. Test components did not improve renal histopathology in diabetic mice ...
http://apitherapy.blogspot.com/2012/08/propolis-may-protect-against-damage.html
NEWBOULDIA LAEVIS LEAF FACILITATES INSULIN SECRETION, GLUCOSE UPTAKE AND PANCREATIC FUNCTION IN ALLOXAN-INDUCED HYPERGLYCAEMIA...NEWBOULDIA LAEVIS LEAF FACILITATES INSULIN SECRETION, GLUCOSE UPTAKE AND PANCREATIC FUNCTION IN ALLOXAN-INDUCED HYPERGLYCAEMIA...
Abstract The antihyperglycaemic activity of aqueous leaf extract of Newbouldia laevis (ALENL) was evaluated in rats. Twenty-five rats of both sexes (120 - 160 g) were divided into five groups (A-E) of 5 animals each. Group A (control) rats were administered 0.5 ml of distilled water (DW) orally while those in group B received 100 mg/kg body weight of ALENL. Animals in groups C, D and E which induced into hyperglycaemia (intraperitoneal administration of 150 mg/kg body weight of alloxan) were also administered DW, 100 and 200 mg/kg body weight of ALENL respectively, once daily for 14 days. Blood glucose levels (BGL) were determined at an interval of two days. Alloxan significantly (p,0.05) increased BGL in the DW treated hyper-glycaemic animals (DWTHA) from 48.00 ± 1.79 to 142.80 ± 2.35 mg/dl after 24 h. After two days, administration of the extract at 100 and 200 mg/kg body weight increased blood glucose level, but this increase was not statistically significant (p,0.05) when compared with the ...
http://ijpsr.com/bft-article/newbouldia-laevis-leaf-facilitates-insulin-secretion-glucose-uptake-and-pancreatic-function-in-alloxan-induced-hyperglycaemia-in-wistar-rats/
Effects of long-term diabetes on the structure and cell proliferation of the myometrium in the early pregnancy of mice. -...Effects of long-term diabetes on the structure and cell proliferation of the myometrium in the early pregnancy of mice. -...
It is known that the development of diabetic complications in human pregnancy is directly related to the severity and the duration of this pathology. In this study, we developed a model of long-term type 1 diabetes to investigate its effects on the cytoarchitecture, extracellular matrix and cell proliferation during the first adaptation phase of the myometrium for pregnancy. A single dose of alloxan was used to induce diabetes in mice prior to pregnancy. To identify the temporal effects of diabetes the mice were divided into two groups: Group D1 (females that became pregnant 90-100 days after alloxan); Group D2 (females that became pregnant 100-110 days after alloxan). Uterine samples were collected after 168 h of pregnancy and processed for light and electron microscopy. In both groups the histomorphometric evaluation showed that diabetes promoted narrowing of the myometrial muscle layers which was correlated with decreased cell proliferation demonstrated by PCNA immunodetection. In D1, diabetes
https://www.semanticscholar.org/paper/Effects-of-long-term-diabetes-on-the-structure-and-F%C3%A1varo-Salgado/9a80972f61855dc23e02b458482706843e423e2b
Health Arena: Beware of White Processed FoodsHealth Arena: Beware of White Processed Foods
The starchy flour is then given a chlorine gas bath in order to bleach it and make it white. Chlorine gas is a flour bleaching and oxidising agent that is a powerful irritant that is dangerous to inhale. The chlorine gas reacts with the flour to oxidise it and make it white. But it also converts a dough additive called xanthine into a toxic substance called alloxan. The latter is a toxin which destroys pancreatic islet cells resulting in diabetes. Alloxan has been used in lab tests to deliberately induce diabetes in rats. Trace elements of alloxan are left in the end product. ...
http://health-arena.blogspot.com/2012/02/beware-of-white-processed-foods.html
Serum Lipase and Alloxan Diabetes in Rats | ScienceSerum Lipase and Alloxan Diabetes in Rats | Science
Thank you for your interest in spreading the word about Science.. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.. ...
https://science.sciencemag.org/content/110/2850/168
Journal of Biosciences | Indian Academy of SciencesJournal of Biosciences | Indian Academy of Sciences
The reticulocytes and the ageing red blood cells (RBCs) namely young (Y), middle-aged (M) and old RBCs (O) of female Wistar rats from different groups such as control animals (C), controls treated with vanadate (C + V), alloxan-induced diabetic (D), diabetic-treated with insulin (D + I) and vanadate (D + V), were fractionated on a percoll/BSA gradient. The following enzymes were measured-hexokinase (HK), glutathione peroxidase (GSH-Px), glutathione reductase (GSSG-R), glutathione-s-transferase (GST), alanine aminotransferase ΜlaAT), aspartate aminotransferase ΜsAT) and arginase in the hemolysates of all the RBCs fractions. Decreases in the activity of HK and AsAT by about 70%, arginase and GSH-Px by 30% in old RBCs were observed in comparison to reticulocytes of control animals. Increases in the activity of GSSG-R by 86%, AlaAT by more than 400% and GST by 70% were observed in old RBCs in comparison to reticulocytes of control animals.. Alloxan diabetic animals showed a further decrease in the ...
https://www.ias.ac.in/listing/articles/jbsc/029/01
Nonenzymatic Glucosylation of Serum Proteins and Hemoglobin: Response by J W. BaynesNonenzymatic Glucosylation of Serum Proteins and Hemoglobin: Response by J W. Baynes
The relationship between concentrations of blood glucose and nonenzymatically glucosylated serum proteins was studied in rats with alloxan-induced diabetes of varying severity. Fasting serum glucose correlated strongly with both glucosylated albumin (r = 0.91, P less than 0.001) and glucosylated serum protein (r = 0.93, P less than 0.001). The relative rates of response of serum protein and hemoglobin glycosylation to changes in blood glucose were also compared. Following withdrawal of insulin from diabetic rats, the half-times to reach new steady state levels of blood glucose, glucosylated serum proteins, and glycohemoglobins were about 2, 3, and 8 days, respectively. Similarly, on reinstitution of insulin therapy, the half-times for these same indices to return to baseline values were 2, 3.5, and 15 days, respectively. Changes in glucosylated albumin were more sensitive than glycohemoglobins to changes in serum glucose, consistent with the observation that albumin was glucosylated at about 10 times
https://scholarcommons.sc.edu/biol_facpub/164/
Pre-diabetic Clinical Changes Induced by Low Doses of Alloxan-Streptozotocin Cocktail in RabbitsPre-diabetic Clinical Changes Induced by Low Doses of Alloxan-Streptozotocin Cocktail in Rabbits
Background & Objectives: Alloxan & streptozotocin are used for inducing diabetic models. Their combination has been used to reduce the individual chemical dosage and minimize the side effects. Present investigation was aimed at studying pre-diabetic clinical changes induced by low doses of Alloxan-STZ cocktail in rabbits. Methods: New Zealand White rabbits, 1-1.5 kg body weight, were administered alloxan (@50 mg/kg b.w.) and STZ (@ 35mg/kg b.w.) cocktail, as single intravenous dose. Blood glucose levels were monitored (0 h, 20 min, 1 h, and then hourly up to 9 h) and clinical signs noted. Rabbits surviving up to 9 hours were given glucose therapy. Results: The cocktail caused immediate transient hypoglycaemia, followed by hyperglycaemia, and then progressively severe hypoglycaemia. Hypoglycaemia caused characteristic behavioural alterations from lethargy, through aesthesia, muscular weakness to recumbency. Severely affected rabbits revealed intermittent convulsions and died in coma. Conclusion: Low
http://ijp.iranpath.org/article_7703.html
HYPOLIPIDEMIC AND ANTIOXIDANT CAPACITY OF METHANOL LEAF EXTRACT OF KIGELIA AFRICANA IN ALLOXAN INDUCED DIABETIC ALBINO RATSHYPOLIPIDEMIC AND ANTIOXIDANT CAPACITY OF METHANOL LEAF EXTRACT OF KIGELIA AFRICANA IN ALLOXAN INDUCED DIABETIC ALBINO RATS
free project topics, download complete project material, hire a writer, research topics in nigeria, kenya, ghana, south africa, undergraduate, postgraduate, final year students, free research project, business administration topics, mass communication, accounting, computer science, economics, statistics, education
https://www.projectreserve.com/2020/01/hypolipidemic-and-antioxidant-capacity-of-methanol-leaf-extract-of-kigelia-africana-in-alloxan-induced-diabetic-albino-rats.html
Coach Kevin Dineen: 10-Pack of Nutrition and Fitness FactsCoach Kevin Dineen: 10-Pack of Nutrition and Fitness Facts
2. Chlorine dioxide, one of the chemicals used to bleach flour, combines with residual protein in most of these foods to form alloxan. In the lab, researchers use alloxan to induce diabetes in rats. Enriched or white anything, is dangerous, period ...
http://coachkevdineen.blogspot.com/2011/01/10-pack-of-nutrition-and-fitness-facts.html
Nigerian Propolis May Help Treat DiabetesNigerian Propolis May Help Treat Diabetes
According to our previous studies, propolis of Nigerian origin showed some evidence of hypoglycemic and hypolipidemic activities in addition to its ability to ameliorate oxidative-stress-induced organ dysfunction. This study was carried out to determine whether an ethanolic extract of Nigerian propolis (EENP) improves glycated hemoglobin A1c (HbA1c), fasting plasma glucose, very low-density lipoprotein (VLDL), and high-density lipoprotein (HDL) concentrations in rats that have alloxan diabetes ...
http://apitherapy.blogspot.com/2016/07/nigerian-propolis-may-help-treat.html
Suppression of aging process (part 2) - Suppressing the incidence of diabetic symptomsSuppression of aging process (part 2) - Suppressing the incidence of diabetic symptoms
In the experiment, we used a technique for administering special material (alloxan) and causing diabetes in healthy mice and, by analyzing and comparing the blood glucose level of mice that been irradiated by a low dose of radiation and mice that were not irradiated, we examined whether low dose irradiation controlled the incidence of diabetes ...
http://criepi.denken.or.jp/en/rsc/contents/Research_Results/Research_Results_5.html
Browsing by Subject Azadirachta indica J, antihyperglycaemic, alloxan, ethanol extractBrowsing by Subject Azadirachta indica J, antihyperglycaemic, alloxan, ethanol extract
This study was aimed to determine antihyperglycaemic effect of Azadirachta indica J extract on alloxan-induced diabetic rat, active compound indentification, and tablet formulation This study used 18 mice Spraque Dawley ...
https://repository.ipb.ac.id/browse?type=subject&value=Azadirachta+indica+J%2C+antihyperglycaemic%2C+alloxan%2C+ethanol+extract
Effect of ficus relegiosa on blood glucose and total lipid levels of normal and alloxan diabetic rabbits. | CureHunterEffect of ficus relegiosa on blood glucose and total lipid levels of normal and alloxan diabetic rabbits. | CureHunter
Effect of ficus relegiosa on blood glucose and total lipid levels of normal and alloxan diabetic rabbits. - Noreen Wadood, Abdul Wadood, Mohammed Nisar
http://www.curehunter.com/public/pubmed15067832.do
Hypoglycemic effect of Nyctanthes arbor-tristis leaf extract on Alloxan induced Diabetic rabbitsHypoglycemic effect of Nyctanthes arbor-tristis leaf extract on Alloxan induced Diabetic rabbits
ABSTRACT. Currently available drugs for diabetes mellitus pose considerable side effects. This necessitates the development of new products, particularly herbal preparations which are known to have lesser side effects. Several herbal products are used to treat diabetes; but their hypoglycemic effects are complex and few anti-diabetic plants have received proper scientific validation. The present study was undertaken to validate the use of the leaves of Nyctanthes arbor-tristis plant as anti-diabetic agent. This study was conducted on thirty healthy albino rabbits of either sex; the effect of the Nyctanthes arbor-tristis leaf extract (NALE) at doses 200mg/kg body weight and 400mg/kg body weight was evaluated for a period of 14 days on alloxan induced diabetic rabbits. The hypoglycemic effect of the leaf extract was compared with the standard Glibenclamide at dose 2.5mg/kg body weight. Results revealed that the hypoglycemic effect of the Nyctanthes arbor-tristis leaf extract at 200mg/kg body ...
http://www.ajptr.com/archive/volume-2/december-2012-issue-6/article-467.html
The effect of alloxan-induced diabetes on anti-nociception and on the development of morphine tolerance and dependence in ratsThe effect of alloxan-induced diabetes on anti-nociception and on the development of morphine tolerance and dependence in rats
Diabetes is one of the most common diseases in all societies including Iran. One of its important complications is the neuropathic pain, which can be relieved by opioid drugs such as morphine. Opioid therapy is restricted due to development of tolerance and physical or mental dependence. In this study, the effect of diabetes on morphine analgesia and development of morphine tolerance and dependence was investigated. Experimental diabetes was induced by alloxan (120 mg/kg, s.c.) in rats. Morphine sulfate (7 mg/kg, i.p.) application for 5 days developed tolerance in animals. On 5th day, 30 min after the injection of morphine, the acute and chronic pain was evaluated in diabetic and non-diabetic animals using hot plate and formalin test. In addition, withdrawal signs (jumping, chewing, urine and feces) were recorded for ten minutes using naloxone (2 mg/kg, s.c.). The results showed that the anti-nociceptive effect of morphine for acute pain markedly reduced, but slightly enhanced for chronic pain model.
http://ijpr.sbmu.ac.ir/article_155.html
Histomorphometric evaluation of bone regeneration using autogenous bone and beta-tricalcium phosphate in diabetic rabbitsHistomorphometric evaluation of bone regeneration using autogenous bone and beta-tricalcium phosphate in diabetic rabbits
Background/Aim. The mechanism of impaired bone healing in diabetes mellitus includes different tissue and cellular level activities due to micro- and macrovascular changes. As a chronic metabolic disease with vascular complications, diabetes affects a process of bone regeneration as well. The therapeutic approach in bone regeneration is based on the use of osteoinductive autogenous grafts as well as osteoconductive synthetic material, like a β-tricalcium phosphate. The aim of the study was to determine the quality and quantity of new bone formation after the use of autogenous bone and β-tricalcium phosphate in the model of calvarial critical-sized defect in rabbits with induced diabetes mellitus type I. Methods. The study included eight 4-month-old Chincilla rabbits with alloxan-induced diabetes mellitus type I. In all animals, there were surgically created two calvarial bilateral defects (diameter 12 mm), which were grafted with autogenous bone and β-tricalcium phosphate (n = 4) or served as ...
http://ibiss-r.rcub.bg.ac.rs/handle/123456789/2502
Hypoglycemic and antilipidemic properties of kombucha tea in alloxan-induced diabetic rats | BMC Complementary and Alternative...Hypoglycemic and antilipidemic properties of kombucha tea in alloxan-induced diabetic rats | BMC Complementary and Alternative...
Diabetes has become a serious health problem and a major risk factor associated with troublesome health complications, such as metabolism disorders and liver-kidney dysfunctions. The inadequacies associated with conventional medicines have led to a determined search for alternative natural therapeutic agents. The present study aimed to investigate and compare the hypoglycemic and antilipidemic effects of kombucha and black tea, two natural drinks commonly consumed around the world, in surviving diabetic rats. Alloxan diabetic rats were orally supplied with kombucha and black tea at a dose of 5 mL/kg body weight per day for 30 days, fasted overnight, and sacrificed on the 31st day of the experiment. Their bloods were collected and submitted to various biochemical measurements, including blood glucose, cholesterol, triglcerides, urea, creatinine, transaminases, transpeptidase, lipase, and amylase activities. Their pancreases were isolated and processed to measure lipase and α-amylase activities and to
https://bmccomplementalternmed.biomedcentral.com/articles/10.1186/1472-6882-12-63
Guarana (Paullinia cupana) consumption improves hepatic and renal parameters in alloxan-induced diabetic ratsGuarana (Paullinia cupana) consumption improves hepatic and renal parameters in alloxan-induced diabetic rats
Results:. LDL (CG: 24.64 ± 2,59; GG: 38.93 ± 7.19; DG: 14.9 ± 3.96; DGG: 20.8 ± 4.04 mg/dL); HDL (CG: 14.8 ± 4.86; GG: 13 ± 1.41; DG: 22.5 ± 7.81; DGG: 30.66 ± 9.02 mg/dL); ALT (CG: 31.8 ± 4.81; GG: 22.16 ± 1.83; DG: 38 ± 1.4; DGG: 26.83 ± 2.13 U/L); AST (CG: 101.8 ± 5.07; GG: 117.5 ± 9.73; DG: 183.6 ± 4.21; DGG: 116.16 ± 12 U/L); urea (CG: 51.4 ± 5.03; GG: 42.5 ± 8.24; DG: 129.16 ± 31.72; DGG: 150.5 ± 36.02 mg/dL); creatinine (CG: 0.6 ± 0.12; GG: 0.53 ± 0.05; DG: 0.78 ± 0.11; DGG: 0.61 ± 0.07 mg/dL). ...
http://scielo.isciii.es/scielo.php?script=sci_abstract&pid=S0212-16112020000300017&lng=es&nrm=iso&tlng=en
Improvement of Dissolution Rate of Gliclazide Using Solid Dispersions with Aerosil 380 and Its Effect on Alloxan Induced...Improvement of Dissolution Rate of Gliclazide Using Solid Dispersions with Aerosil 380 and Its Effect on Alloxan Induced...
The main objective of this research is to conduct a comprehensive study for enhancing the aqueous solubility of poorly water soluble gliclazide using hydrophilic fumed silica particles (Aerosil® 380) and evaluating the influence of silica on drug release profile and pharmacological activity on alloxan induced diabetic rats. Solid dispersions (SDs) of gliclazide were prepared using solvent evaporation method. The dissolution profiles and solid state characterization of the SDs prepared were all evaluated. The dissolution rate of gliclazide in the SDs with fumed silica (weight ratio, 1:1) was approximately 38%, which is about 10 fold higher than that of the pure drug after 30 min. After forming the SDs, gliclazide changed into an amorphous state, which can infer from differential scanning calorimetry (DSC) and powder X-ray diffraction (PXRD). Fourier transform infrared spectroscopy (FTIR) also revealed the formation of weak hydrogen bonding through the interactions between the secondary
https://www.scirp.org/journal/paperinformation.aspx?paperid=94508
Plus itPlus it
Using calcium imaging as a marker of neuronal excitability, we detected glucose-excited, glucose-inhibited, and nonresponsive neurons in primary hypothalamic cell cultures, in proportions similar to those described previously (1,23). Thus, ∼30% of neurons were excited by raising the glucose concentration from 3 to 15 mmol/l, ∼6% were inhibited, and the remainder were nonresponsive over the same concentration range. The mechanism of glucose sensing in the glucose-excited neurons could not be attributed solely to KATP channel closure because tolbutamide only increased intracellular Ca2+ in ∼10% of glucose-excited neurons in the presence of 3 mmol/l glucose. Furthermore, the nonmetabolizable sugars αMDG and 3-O-MDG mimicked the action of glucose in glucose-excited neurons, indicating that metabolic generation of ATP is not a prerequisite for the sensing of glucose analogs. The sensitivity of the glucose-sensing machinery to αMDG, its dependence on extracellular Na+, and its inhibition by ...
http://diabetes.diabetesjournals.org/content/55/12/3381
Anti-diabetic Activity Of Polyherbal Formulation Containing Some Bitter Plant Constituents In Alloxan Induced Diabetic RatsAnti-diabetic Activity Of Polyherbal Formulation Containing Some Bitter Plant Constituents In Alloxan Induced Diabetic Rats
The present study was aimed to evaluate the anti diabetic activity of polyherbal formulation containing some bitter plant constituents like neem, methi, karela fruit, amla , jamun seeds, kavat fruit in
http://www.journalijar.com/article/1012/anti-diabetic-activity-of-polyherbal-formulation-containing-some-bitter-plant-constituents-in-alloxan-induced-diabetic-rats/
RJPT - Anti-Diabetic Activity of Aqueous Extract of Leaves of Pavonia zeylanica in Rats
The hypoglycemic effect of aqueous extract of leaves of Pavonia zeylanica (AEPZ) was evaluated in normal, glucose fed and alloxan-induced diabetic rats. Oral administration of extract (200 and 400mg/kg body wt) for 7 days resulted in a significant reduction in blood glucose level. The effect was compared with 0.5gm/kg (.P) glibenclamide.
https://rjptonline.org/AbstractView.aspx?PID=2009-2-4-99
Dokument bez názvuDokument bez názvu
Mushrooms are a low calorie food with very little fat and are highly suitable for obese persons. The objective of the present investigation was to study the interaction of aqueous extract of P. pulmonarius (called PP-aqu) with acarbose on serum glucose levels, and on the oral glucose tolerance test (OGTT) in alloxan induced diabetic mice. PP-aqu (500 mg/kg), acarbose (50 mg/kg) and their combination were administered orally in alloxan (70 mg/kg i.v.) induced diabetic mice. In the acute study, the serum glucose level was estimated at 0, 2, 4, 6 and 24 h after drug administration. The subacute study involved repeated administration of the drugs for 28 days, a serum glucose level estimation at 7, 14, 21 and 28 days and recording of the body weights of the mice. In the OGTT, D-glucose (2.5 g/kg) was administered in diabetic mice half an hour after pre-treatment with PP-aqu (500 mg/kg), acarbose (50 mg/kg) and their combination. Serum glucose levels were estimated 30 min prior to glucose ...
http://jab.zsf.jcu.cz/5_3/badole.htm
ALLOXAN IN THE TREATMENT OF A CASE OF ISLET CELL CARCINOMA OF THE PANCREAS WITH LIVER METASTASES* | Annals of Internal Medicine...ALLOXAN IN THE TREATMENT OF A CASE OF ISLET CELL CARCINOMA OF THE PANCREAS WITH LIVER METASTASES* | Annals of Internal Medicine...
Organic hyperinsulinism has been recognized with increasing frequency in the last few years. It is most commonly due to adenomata of the islands of Langerhans. More and more case reports appear of successful surgical removal of these tumors with consequent alleviation of symptoms. At times there seems to be a general hypersecretion of insulin by the islet cells without discernible tumor in which resection of varying amounts of pancreatic tissue has been found effective. Carcinoma of islet cells occurs much less frequently. In these cases the tumor is often slow to grow and slow to metastasize. In a few instances ...
http://annals.org/aim/article/673604/alloxan-treatment-case-islet-cell-carcinoma-pancreas-liver-metastases
Clinical use and time relationship of changes in affinity measurement of glycosylated albumin and glycosylated hemoglobin<...
TY - JOUR. T1 - Clinical use and time relationship of changes in affinity measurement of glycosylated albumin and glycosylated hemoglobin. AU - Rendell, M.. AU - Paulsen, R.. AU - Eastberg, S.. AU - Stephen, P. M.. AU - Valentine, J. L.. AU - Smith, C. H.. AU - Nierenberg, J.. AU - Rasbold, K.. AU - Klenk, D.. AU - Smith, P. K.. PY - 1986/1/1. Y1 - 1986/1/1. N2 - Simple techniques for measurement of glycosylated hemoglobin and glycosylated albumin by affinity chromatographyy on m-aminophenylboronic acid agarose columns have recently been developed. This study explored the time course of changes in glycoalbumin versus those of glycohemoglobin in response to rapid changes in ambient glucose concentration. One would predict that glycoalbumin levels would change more rapidly than glycohemoglobin levels due to the shorter half-life of albumin than hemoglobin. This was found to be the case in a group of rabbits rendered diabetic with alloxan. Glycoalbumin levels plateaued 4 weeks after alloxan ...
https://creighton.pure.elsevier.com/en/publications/clinical-use-and-time-relationship-of-changes-in-affinity-measure
Alloxan - Everything2.comAlloxan - Everything2.com
Al*loxan (#), n. [Allantoin + oxalic, as containing the elements of allantion and oxalic acid.] Chemistry|Chem. An oxidation produ...
https://everything2.com/title/Alloxan
Increase in T cell surface thiol levels are linked with activation and diabetogenicity | The Journal of ImmunologyIncrease in T cell surface thiol levels are linked with activation and diabetogenicity | The Journal of Immunology
Free radicals contribute to Type 1 diabetes (T1D) autoimmune responses. We recently demonstrated that superoxide-deficient CD4 T cells exhibited increased effector responses and diabetogenicity, but the redox-dependent mechanism(s) mediating T cell activation were unclear. We hypothesized that during T1D progression, CD4 T cells with a reduced cell surface state would exhibit a concomitant increase in pro-inflammatory cytokine and chemokine responses. To test this, alexa fluor 647-conjugated maleimide (ALM)-labeling of cell surface reduced thiols on diabetogenic mouse and human CD4 T cells was performed. We observed an increase in ALM percentage and gMFI from peripheral Non-obese diabetic (NOD) mouse CD4 T cells during progression to overt diabetes. Cognate autoantigen stimulation elicited a 2- and 20-fold increase in CD4 ALM T cell percentage and gMFI, respectively. In addition to serving as a T cell activation marker, ALM gMFI of reduced CD4 T cell surface thiols was enhanced (1.2-fold) with ...
http://www.jimmunol.org/content/198/1_Supplement/58.10
Fast exocytosis with few Ca(2+) channels in insulin-secreting mouse pancreatic B cells. - Radcliffe Department of MedicineFast exocytosis with few Ca(2+) channels in insulin-secreting mouse pancreatic B cells. - Radcliffe Department of Medicine
The association of L-type Ca(2+) channels to the secretory granules and its functional significance to secretion was investigated in mouse pancreatic B cells. Nonstationary fluctuation analysis showed that the B cell is equipped with |500 alpha1(C) L-type Ca(2+) channels, corresponding to a Ca(2+) channel density of 0.9 channels per microm(2). Analysis of the kinetics of exocytosis during voltage-clamp depolarizations revealed an early component that reached a peak rate of 1.1 pFs(-1) (approximately 650 granules/s) 25 ms after onset of the pulse and is completed within approximately 100 ms. This component represents a subset of approximately 60 granules situated in the immediate vicinity of the L-type Ca(2+) channels, corresponding to approximately 10% of the readily releasable pool of granules. Experiments involving photorelease of caged Ca(2+) revealed that the rate of exocytosis was half-maximal at a cytoplasmic Ca(2+) concentration of 17 microM, and concentrations |25 microM are required to attain
https://www.rdm.ox.ac.uk/publications/9662
Pancreatic B Cell Function in Motor Neurone Disease | Clinical Science | Portland PressPancreatic B Cell Function in Motor Neurone Disease | Clinical Science | Portland Press
AJ Krentz, PM Clark, CN Hales, AC Williams, M Nattrass; Pancreatic B Cell Function in Motor Neurone Disease. Clin Sci (Lond) 1 July 1992; 83 (s27): 5P. doi: https://doi.org/10.1042/cs083005P. Download citation file:. ...
https://portlandpress.com/clinsci/article-abstract/83/s27/5P/103758/Pancreatic-B-Cell-Function-in-Motor-Neurone
PHARMACEUTICAL COMPOSITIONS BASED ON A MICROEMULSION - Patent applicationPHARMACEUTICAL COMPOSITIONS BASED ON A MICROEMULSION - Patent application
TABLE-US-00003 TABLE 2 Pharmacokinetic parameters of insulin after IV, SC and IN administration to diabetic rabbits IV* SC IN IV* SC IN PK parameter 0.5 IU/kg 0.5 IU/kg 1 IU/kg 0.5 IU/kg 0.5 IU/kg 1 IU/kg Diabetic Rabbit #1 Diabetic Rabbit #2 Cmax (mIU/L) 253.7 148.4 106.5 183.1 71.6 167.3 tmax (min) 2 15 15 5 30 15 ?z (min-1) .0113 0.0263 0.0189 0.03 0.0047 0.0026 Elimination t1/2 61.1 26.3 36.7 23.1 149.0 271.1 (min) AUC0-∞ 6638.6 12192.7 5473.1 6145.1 16772.0 8675.1 (mIU min L-1) AUC0-∞/dose 13277.2 24385.5 5473.1 12290.2 33544.1 8675.1 (mIU min L-1 D-1) FRa (%) 100 100 22.4 100 100 25.9 FAb (%) 100 100 41.2 100 100 70.6 Diabetic Rabbit #3 Diabetic Rabbit #4 Cmax (mIU/L) 268.3 121.5 79.5 267.2 72.5 89.8 tmax (min) 15 15 15 5 45 15 ?z (min-1) 0.0097 0.0164 0.0235 0.0148 0.0119 0.0218 Elimination t1/2 71.7 42.3 29.4 46.8 58.4 31.9 (min) AUC0-∞ 6628.2 12798.8 3644.5 5816.2 9130.1 3845.4 (mIU min L-1) AUC0-∞/dose 13256.4 25597.7 3644.5 11632.4 18260.2 3845.4 (mIU min L-1 D-1) FRa (%) 100 ...
http://www.patentsencyclopedia.com/app/20100034880
This therapeutic approach is relatively simple in regard o - joketree icu
Compartmentalization of PDGF on extracellular binding sites dependent on exon-6-encoded sequences. Inclusion of methionine-S35 into liver slices of rats with alloxan diabetes in a medium containing glucose generic cialis or fructose Hence, fluopyram has a harmful effect on overall soil microbial activity, and tadalafil 20 mg rezeptfrei bestellen changed soil microbial community structure and function. Six males with type 2 diabetes mellitus and eight healthy controls were included.. Long sleep duration: a nonconventional indicator of arterial stiffness in Japanese at high risk of cardiovascular disease: side effects of cialis the J-HOP study. How does the number of susceptible cells influence the growth potential of the virus?. The presence of an osseous spur on the dorsoproximal aspect of MtIII in the absence of other radiological abnormalities may be an incidental finding. AfsR recruits tadalafil 5mg RNA polymerase to the afsS promoter: a model for transcriptional activation by SARPs. The ...
http://joketree.icu/this-therapeutic-approach-is-relatively-simple-in-regard-o/
DI-fusion Protective effect of schisanhenol against alloxan-induced...
DI-fusion, le Dépôt institutionnel numérique de lULB, est loutil de référencementde la production scientifique de lULB.Linterface de recherche DI-fusion permet de consulter les publications des chercheurs de lULB et les thèses qui y ont été défendues.
http://difusion.ulb.ac.be/vufind/Record/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/78705/Details
EFFECT OF DEHYDROASCORBIC ACID ON THE ISLETS OF LANGERHANS OF THE RAT PANCREAS | JCBEFFECT OF DEHYDROASCORBIC ACID ON THE ISLETS OF LANGERHANS OF THE RAT PANCREAS | JCB
Rat pancreatic islets have been studied following successive daily administration of dehydroascrobic acid (DHA) and during the recovery phase following 3 daily injections. One injection of DHA produces degranulation of B cells seen in the light microscope as a loss of aldehyde fuchsin positivity. In the electron microscope the B cells appear to have secretory granules accumulated subjacent to the plasma membranes. Following 2 and 3 daily injections, B cells evidence alterations in the organization of the granular endoplasmic reticulum and mitochondria, and secretory granules are scant but when present are subjacent to the plasma membrane. After 5 to 7 days recovery few secretory granules remain in B cell cytoplasm, but the cells have prominent granular ER and a Golgi apparatus with numerous prosecretory granules. The primary effect of DHA is an exaggerated secretory response of B cells, which is intensified with subsequent injections. Necrosis of B cells as produced by alloxan is not ...
http://jcb.rupress.org/content/26/1/245
think loud: sound scientific reason to avoid pizzas and parathasthink loud: sound scientific reason to avoid pizzas and parathas
Maida is made from wheat flour after removing the fiber rich bran. Then it is bleached with the chemical alloxan to make it white and fine. This chemical is toxic to Pancreas in our body. Pancreas is responsible for regulation of glucose and sugar in our body and blood. Pancreas is producing insulin in our body. Actually Insulin is responsible for the control of blood sugar. Once Pancreas is damaged, one will become diabetic. Pancreas can be damaged in many ways. Our genes and heredity also have a role in making Pancreas susceptible to injury by noxious agents. Maida or white wheat flour is used in many food stuffs world wide. The big corporate lobby world wide has succeeded in hiding the harmful effect of Maida and disseminating the information. The food industry was able to prevent any research to rule out the causation of DIABETES by Maida. The incidence of diabetes mellitus is increasing worldwide and India and Kerala is going to get the number one place in this regard. May be our food ...
http://arvindsdad.blogspot.com/2012/01/sound-scientific-reason-to-avoid-pizzas.html
Zucchini | GreenMedInfo | Substance | Natural Medicine | AlternativeZucchini | GreenMedInfo | Substance | Natural Medicine | Alternative
This topic has 3 study abstracts on Zucchini indicating that it may have therapeutic value in the treatment of Alloxan toxicity, Diabetes Mellitus: Type 1, and Aspirin-Induced Toxicity
https://video.greenmedinfo.com/substance/zucchini
SJMPS 2(10) - Scholars Middle East PublishersSJMPS 2(10) - Scholars Middle East Publishers
In vivo antidiabetic efficacy of red algae Portieria hornemannii and Spyridia fusiformis methanol extract on alloxan stimulated hyperglycemic activity in Wistar albino rats ...
http://scholarsmepub.com/sjmps-210/
JoVE Author Search: E Silva PM
Advanced Glycation End Products, Alloxan, Antigen, Apoptosis, Behavior, Cell, Cell Number, Cell Numbers, Cells, Family, Fluorescence, Fructosamine, Histamine, Histamine Release, Injection, Intravenous Injection, Mast Cell, Mast Cells, Plasma, Pleural Cavity
http://labindex.jove.com/author/E-Silva-PM
No Species FoundNo Species Found
No species in the database contian data from the requested reference: Stiehler, R.D.; Huffman, H.M., Thermal data: V the heat capacities, entropies and free energies of adenine, hypoxanthine, guanine, xanthine, uric acid, allantoin and alloxan, J. Am. Chem. Soc., 1935, 57, 1741-3. ...
https://webbook.nist.gov/cgi/cbook.cgi?Source=1935STI%2FHUF1741-3&Units=SI&Mask=FFFF
KAKEN - Researchers | ARAKAWA Michio (60092912)KAKEN - Researchers | ARAKAWA Michio (60092912)
Affiliation：Gifu University School of Medicine,Second Department of Internal Medicine,Assistant Professor of Medicine,医学部・附属病院,講師, Research Field：循環器内科学, Keywords：対側肺傷害,アラキドン酸代謝産物,Intravenous injection,Intratracheal instillation,二重指示薬希釈法,Alloxan-induced lung injury,アロキサン肺水腫,血管外肺水分量,成人呼吸窮迫症候群,Antiprotease, # of Research Projects：1, # of Research Products：0
https://nrid.nii.ac.jp/nrid/1000060092912/
December | 2013 | akt inhibitor
Later on while in the program from the disease there exists enhanced expression of your transforming growth element b, which may perhaps result, in aspect, in the elevated production of MCP 1. Each the MCP 1 and also the TGF b1 genes have CpG situated from the vicinity of transcription begin website. The OVE26 mice on FVB background overexpress cal modulin gene in pancreatic b cells, leading to hyper glycemia and early onset of kind 1 diabetes and diabetic nephropathy. The leptin deficient insulin resis tant C57BL/6J ob/ob mice are mildly hyperglycemic and do not build kidney lesions resembling human dia betes. We utilized chromatin through the kidneys of those strains and their respective controls inside the com bined ChIP MeDIP assay. Blood glucose levels in these strains had been as follows C57BL/6J 65 4, C57BL/6 ob/ob 112 13, FVB 197 15, and FVB OVE26 649 22. Matrix ChIP MeDIP analysis uncovered reduced 5mC ranges in the MCP 1 gene in the diabetic OVE26 mice when compared with the usual FVB ...
https://aktinhibitor.com/2013/12
C-Peptide | Lab Tests | 5MinuteConsultC-Peptide | Lab Tests | 5MinuteConsult
Human C-peptide is a 31-amino-acid chain with a molecular mass of approximately 3,020 Da. Metabolically inert, it originates in the pancreatic B cells as a by-product of the enzymatic clea... ...
https://5minuteconsult.com/collectioncontent/2-152261/lab-tests/c-peptide
AlloxanAlloxan
... , sometimes referred to as alloxan hydrate, is the name of the organic compound with the formula OC(N(H)CO)2C(OH)2. It ... The name "Alloxan" emerged from an amalgamation of the words "allantoin" and "Oxalsäure" (oxalic acid). The alloxan model of ... Studies suggests that alloxan does not cause diabetes in humans. Others found a significant difference in alloxan plasma levels ... A dimeric derivative alloxantin can be prepared by partial reduction of alloxan with hydrogen sulfide. Alloxan is a toxic ...
https://en.wikipedia.org/wiki/Alloxan
Passiflora glandulosaPassiflora glandulosa
in alloxan-induced diabetic mice". World Journal of Pharmacy and Pharmaceutical Sciences. 4: 1571-1586 - via Research Gate.{{ ...
https://en.wikipedia.org/wiki/Passiflora_glandulosa
Stevia rebaudianaStevia rebaudiana
Bertoni) on alloxan-induced diabetic rats". J Pharm Bioallied Sci. 3 (2): 242-8. doi:10.4103/0975-7406.80779. PMC 3103919. PMID ...
https://en.wikipedia.org/wiki/Stevia_rebaudiana
Stevia (genus)Stevia (genus)
Bertoni) on alloxan-induced diabetic rats". Journal of Pharmacy and Bioallied Sciences. 3 (2): 242-248. doi:10.4103/0975- ...
https://en.wikipedia.org/wiki/Stevia_(genus)
Momordica cymbalariaMomordica cymbalaria
Fruit powder in alloxan-diabetic rats". Journal of Ethnopharmacology. 67 (1): 103-109. doi:10.1016/S0378-8741(99)00004-5. PMID ...
https://en.wikipedia.org/wiki/Momordica_cymbalaria
StreptozotocinStreptozotocin
Alloxan Brentjens R, Saltz L (2001). "Islet cell tumors of the pancreas: the medical oncologist's perspective". Surg Clin North ... Szkudelski T (2001). "The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas". Physiol Res. 50 (6): ... "Comparison of metabolic abnormalities in diabetes mellitus induced by streptozotocin or by alloxan". Lancet. 1 (7544): 670-1. ...
https://en.wikipedia.org/wiki/Streptozotocin
Solanum anguiviSolanum anguivi
Fruit in alloxan-induced diabetic Rats". South African Journal of Botany. 88: 56-61. doi:10.1016/j.sajb.2013.04.010. ...
https://en.wikipedia.org/wiki/Solanum_anguivi
SteviaStevia
Bertoni) on alloxan-induced diabetic rats". J Pharm Bioallied Sci. 3 (2): 242-248. doi:10.4103/0975-7406.80779. PMC 3103919. ...
https://en.wikipedia.org/wiki/Stevia
Pleurotus pulmonariusPleurotus pulmonarius
with Glyburide in Alloxan Induced Diabetic Mice". Evidence-Based Complementary and Alternative Medicine. 5 (2): 159-164. doi: ... and reduced the mortality of alloxan induced diabetic mice by approximately 50%. It showed a synergistic effect with the ...
https://en.wikipedia.org/wiki/Pleurotus_pulmonarius
Robert Hardin WilliamsRobert Hardin Williams
Steiner, Donald F.; Rauda, Vija; Williams, Robert H. (1961). "Severe Ketoacidosis in the Alloxan Diabetic Rat". Endocrinology. ...
https://en.wikipedia.org/wiki/Robert_Hardin_Williams
Maud MentenMaud Menten
Menten, ML.; Janouch, M. (1946). "Changes in alkaline phosphatase of kidney following renal damage with alloxan". Proceedings ...
https://en.wikipedia.org/wiki/Maud_Menten
MurexideMurexide
It may also be prepared by digesting alloxan with alcoholic ammonia. Justus von Liebig and Friedrich Wöhler in Giessen, Germany ...
https://en.wikipedia.org/wiki/Murexide
Violuric acidVioluric acid
It can also be produced by condensation of alloxan with hydroxylamine. as typical for forming the oxime of other carbonyl ...
https://en.wikipedia.org/wiki/Violuric_acid
Annona stenophyllaAnnona stenophylla
"Hypoglycemic Effects ofAnnona stenophyllaandMorus albaPlant Extracts in Alloxan-induced Diabetic Mice". Journal of Biologically ...
https://en.wikipedia.org/wiki/Annona_stenophylla
TaurineTaurine
... antioxidative and nephroprotective effects of taurine in alloxan diabetic rabbits". Biochimie. 91 (2): 261-270. doi:10.1016/j. ...
https://en.wikipedia.org/wiki/Taurine
Artemisia pallensArtemisia pallens
On blood glucose levels in normal and alloxan-induced diabetic rats". Journal of Ethnopharmacology. 50 (1): 13-7. doi:10.1016/ ... fed hyperglycemic and alloxan-treated rabbits and rats. Davana oil is used in making perfumes of sweet and fruity fragrances. ...
https://en.wikipedia.org/wiki/Artemisia_pallens
Laboratory Syrian hamsterLaboratory Syrian hamster
Streptozotocin or alloxan may be administered to induce chronic diabetes in hamsters. Atherosclerosis may be studied with ...
https://en.wikipedia.org/wiki/Laboratory_Syrian_hamster
Albert RenoldAlbert Renold
He completed his MD with a thesis on diabetes caused by alloxan. After graduating from the University of Zurich, Renold was ...
https://en.wikipedia.org/wiki/Albert_Renold
Strecker degradationStrecker degradation
Strecker, A (1862). "Notiz über eine eigenthümliche Oxydation durch Alloxan" [Notice of a curious oxidation by alloxan]. ... The original observation by Strecker involved the use of alloxan as the oxidant in the first step, followed by hydrolysis: The ...
https://en.wikipedia.org/wiki/Strecker_degradation
Aegiceras corniculatumAegiceras corniculatum
"Antidiabetic effect of a black mangrove species Aegiceras corniculatum in alloxan-induced diabetic rats". J. Adv. Pharm. ...
https://en.wikipedia.org/wiki/Aegiceras_corniculatum
Mladen VranicMladen Vranic
"Importance of glucagon in the control of futile cycling as studied in alloxan-diabetic dogs". Diabetologia. 30 (3): 175-182. ... reduction in pancreatic glucagon with normalization of somatostatin and decrease in insulin in normoglycemic alloxan-diabetic ...
https://en.wikipedia.org/wiki/Mladen_Vranic
Lannea edulisLannea edulis
"Antihyperglycemic and Antihyperlipidemic Effects of Aqueous Extracts of Lannea edulis in Alloxan-Induced Diabetic Rats". ...
https://en.wikipedia.org/wiki/Lannea_edulis
PomiferinPomiferin
Bartosíková, L (2007). "Examination of the antioxidative and antidiabetic effect of pomiferin in alloxan-induced diabetes ...
https://en.wikipedia.org/wiki/Pomiferin
Gymnema sylvestreGymnema sylvestre
"Absence of antidiabetic and hypolipidemic effect of Gymnema sylvestre in non-diabetic and alloxan-diabetic rats". Braz. Arch. ...
https://en.wikipedia.org/wiki/Gymnema_sylvestre
PyrimidinePyrimidine
Although pyrimidine derivatives such as alloxan were known in the early 19th century, a laboratory synthesis of a pyrimidine ... Grimaux, E. (1879). "Synthèse des dérivés uriques de la série de l'alloxane" [Synthesis of urea derivatives of the alloxan ... and alloxan. It is also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. ...
https://en.wikipedia.org/wiki/Pyrimidine
Purpuric acidPurpuric acid
... is a nitrogenous acid related to barbituric acid that yields alloxan and uramil upon hydrolysis. It is noteworthy ...
https://en.wikipedia.org/wiki/Purpuric_acid
Fentons reagentFenton's reagent
Brömme, H. J.; Mörke, W.; Peschke, E. (November 2002). "Transformation of barbituric acid into alloxan by hydroxyl radicals: ... free radical substitution Conversion of benzene into phenol by using Fenton's reagent Oxidation of barbituric acid into alloxan ...
https://en.wikipedia.org/wiki/Fenton's_reagent
Helicteres isoraHelicteres isora
"Antihyperglycemic and hypolipidemic effects of Helicteres isora roots in alloxan-induced diabetic rats: a possible mechanism of ...
https://en.wikipedia.org/wiki/Helicteres_isora
PhosphatidylserinePhosphatidylserine
... a study in alloxan-induced diabetic rats". Cell Biochemistry and Function. 26 (8): 859-865. doi:10.1002/cbf.1517. ISSN 1099- ...
https://en.wikipedia.org/wiki/Phosphatidylserine
Friedrich Wilhelm Hermann DelffsFriedrich Wilhelm Hermann Delffs
... molybdate of ammonia and alloxan. In 1843, with mineralogist Johann Reinhard Blum, he proposed the name "leonhardite" for ...
https://en.wikipedia.org/wiki/Friedrich_Wilhelm_Hermann_Delffs
Protective mechanism of reduced water against alloxan-inducedProtective mechanism of reduced water against alloxan-induced
These results suggest that RW protects pancreatic beta-cells from alloxan-induced cell damage by preventing alloxan-derived ROS ... HIT-T15 from alloxan-induced cell damage. Alloxan, a diabetogenic compound, is used to induce type 1 diabetes mellitus in ... Alloxan-treated HIT-T15 cells exhibited lowered viability, increased intracellular ROS levels, elevated cytosolic free Ca(2+) ... RW completely prevented the generation of alloxan-induced ROS, increase of cytosolic Ca(2+) concentration, decrease of ...
https://greenmedinfo.com/article/electrolyzed-reduced-water-ie-structured-water-protects-against-pancreatic-cel
Antidiabetic effect of flax and pumpkin seed mixture powder: effect on hyperlipidemia and antioxidant status in alloxan...Antidiabetic effect of flax and pumpkin seed mixture powder: effect on hyperlipidemia and antioxidant status in alloxan...
This study aims to examine the effects of flax and pumpkin powder seed mixture on alloxan induced diabetes in Wistar rats. ... This study aims to examine the effects of flax and pumpkin powder seed mixture on alloxan induced diabetes in Wistar rats. ... Antidiabetic effect of flax and pumpkin seed mixture powder: effect on hyperlipidemia and antioxidant status in alloxan ...
https://pubmed.ncbi.nlm.nih.gov/21106396/
Biochemical and Haematological Effects of the Leaf Extract of Newbouldia laevis in Alloxan-Induced Diabetic RatsBiochemical and Haematological Effects of the Leaf Extract of Newbouldia laevis in Alloxan-Induced Diabetic Rats
The effects of the extract on the haematological and some biochemical parameters of alloxan-induced diabetic rats were ... Overall, administration of DME has significant ameliorative effect on alloxan-induced anaemia and other haematological ... was used to prevent the initial hypoglycemia caused by alloxan monohydrate [29] . After 3 days of alloxan treatment blood ... Alloxan monohydrate (Sigma, St. Louis, MO, USA) was used to induce diabetes in adult Wistar rats of both sexes. A freshly ...
https://www.scirp.org/journal/paperinformation.aspx?paperid=77221
Pasuchaca (Geranium ruizii Hieron.): A Medicinal Plant of the Geraniaceae Family with Hypoglycemic Effect on Alloxan-Induced...
Pasuchaca (Geranium ruizii Hieron.): A Medicinal Plant of the Geraniaceae Family with Hypoglycemic Effect on Alloxan-Induced ... A Medicinal Plant of the Geraniaceae Family with Hypoglycemic Effect on Alloxan-Induced Hyperglycemia in Mice. Together they ...
https://cris.unica.edu.pe/en/publications/pasuchaca-geranium-ruizii-hieron-a-medicinal-plant-of-the-gerania/fingerprints/
IMSEAR at SEARO: Experimental diabetes in guineapigs by alloxan.
Experimental diabetes in guineapigs by alloxan. Indian Journal of Physiology and Pharmacology. 1961 Jul; 5(): 151-7. ...
https://imsear.searo.who.int/handle/123456789/106442?locale=ar
Alloxan Monohydrate About HighFineAlloxan Monohydrate About HighFine
Alloxan Monohydrate-About HighFine
https://en.highfine.com/product/3193.html
ANTIDIABETIC POTENTIAL OF MATOA BARK EXTRACT (Pometia pinnata) IN ALLOXAN-INDUCED DIABETIC MALE RAT STRAIN WISTAR (Rattus...
ANTIDIABETIC POTENTIAL OF MATOA BARK EXTRACT (Pometia pinnata) IN ALLOXAN-INDUCED DIABETIC MALE RAT STRAIN WISTAR (Rattus ...
https://www.sysrevpharm.org/abstract/antidiabetic-potential-of-matoa-bark-extract-pometia-pinnata-in-alloxaninduced-diabetic-male-rat-strain-wistar-rattus-no-65093.html
View of Age Susceptibility of Wistar Rats to Alloxan-Induced Diabetes: A ParadoxView of Age Susceptibility of Wistar Rats to Alloxan-Induced Diabetes: A Paradox
Return to Article Details Age Susceptibility of Wistar Rats to Alloxan-Induced Diabetes: A Paradox Download Download PDF ...
https://www.notulaebiologicae.ro/index.php/nsb/article/view/10438/9191
Action of Capparis decidua against alloxan-induced oxidative stress and diabetes in rat tissues ePrints@IIScAction of Capparis decidua against alloxan-induced oxidative stress and diabetes in rat tissues [email protected]
Alloxan-induced diabetic rats were treated with insulin (i.p.) or with Capparis decidua powder as a hypoglycaemic agent mixed ... Yadav, P and Sarkar, S and Bhatnagar, D (1997) Action of Capparis decidua against alloxan-induced oxidative stress and diabetes ... Action of Capparis decidua against alloxan-induced oxidative stress and diabetes in rat tissues ...
https://eprints.iisc.ac.in/18030/
Hypoglycemic activity on Putranjiva roxburghii bark. in alloxan induced diabetic ratsHypoglycemic activity on Putranjiva roxburghii bark. in alloxan induced diabetic rats
in alloxan induced diabetic rats. International Journal of Pharmacognosy and Clinical Research, Volume 3, Issue 1, 2021, Pages ... I present diabetes study was induced in albino rat models with the alloxan monohydrate. Putranjiva roxburghii bark. has been ...
https://www.pharmacognosyjournal.in/archives/2021.v3.i1.21
PDF] Aphrodisiac Property of the Elephant Creeper Argyreia nervosa | Semantic ScholarPDF] Aphrodisiac Property of the Elephant Creeper Argyreia nervosa | Semantic Scholar
Hypoglycemic and antihyperglycemic effect of Witheringia solanacea in normal and alloxan-induced hyperglycemic ratsHypoglycemic and antihyperglycemic effect of Witheringia solanacea in normal and alloxan-induced hyperglycemic rats
Dose of 500 mg/kg of the extract significantly reduced (p , 0.05) blood glucose levels in alloxan induced hyperglycemic rats at ... Hypoglycemic and antihyperglycemic effect of Witheringia solanacea in normal and alloxan-induced hyperglycemic rats. dc. ... Hypoglycemic and antihyperglycemic effect of Witheringia solanacea in normal and alloxan-induced hyperglycemic rats. es_ES. ... los niveles de glucosa en sangre en ratas hiperglucémicas inducidas por alloxan a las 4 y 5 h. En conclusión, en el presente ...
https://repositorio.una.ac.cr/handle/11056/23598?show=full
Assessment of the antidiabetic potential of extract and novel phytoniosomes formulation of Tradescantia pallida leaves in the...Assessment of the antidiabetic potential of extract and novel phytoniosomes formulation of Tradescantia pallida leaves in the...
... and alloxan-induced diabetic mice models. The biological parameters evaluated were; change in body weight, blood biochemistry, ... of the antidiabetic potential of extract and novel phytoniosomes formulation of Tradescantia pallida leaves in the alloxan- ...
https://pesquisa.bvsalud.org/brasil/resource/pt/mdl-36856606
Antihyperlipidemic Effects of Ginger Extracts in Alloxan-induced Diabetes and Propylthiouracil-induced Hypothyroidism in (rats)...Antihyperlipidemic Effects of Ginger Extracts in Alloxan-induced Diabetes and Propylthiouracil-induced Hypothyroidism in (rats)...
Al-Noory AS, Amreen A-, Hymoor S. Antihyperlipidemic Effects of Ginger Extracts in Alloxan-induced Diabetes and ... Home / Pharmacognosy Research, Vol 5, Issue 3, Jul-Sep, 2013 / Antihyperlipidemic Effects of Ginger Extracts in Alloxan-induced ... Antihyperlipidemic Effects of Ginger Extracts in Alloxan-induced Diabetes and Propylthiouracil-induced Hypothyroidism in (rats) ... on serum lipid profile and on blood glucose in alloxan-induced diabetes and propylthiouracil-induced hypothyroidism in rats. ...
https://phcogres.com/article/2013/5/3/1041030974-8490112419
Promising anitidiabetic potential of Cuscuta reflexa leaves methanol extract in alloxan-induced diabetic rats | Clinical...Promising anitidiabetic potential of Cuscuta reflexa leaves methanol extract in alloxan-induced diabetic rats | Clinical...
Diabetic model was developed by i.p. administration of alloxan monohydrate (120 mg/kg). Ingestion of CRME (100, 200, and 400 mg ... The antidiabetic activity of C. reflexa leaves methanol extract (CRME) was evaluated using alloxan-induced diabetes in Wistar ... The present investigation focuses on the antidiabetic potential of C. reflexa leaves methanol extract in alloxan-induced ... Furthermore, CRME notably reversed the histopathological changes that observed in alloxan-induced diabetes. Our research ...
https://clinphytoscience.springeropen.com/articles/10.1186/s40816-020-00169-w/figures/1
Effect of turmeric on alloxan induced diabetes mellitus in albino rats | Padhye | International Journal of Basic & Clinical...Effect of turmeric on alloxan induced diabetes mellitus in albino rats | Padhye | International Journal of Basic & Clinical...
Effect of turmeric on alloxan induced diabetes mellitus in albino rats ...
https://www.ijbcp.com/index.php/ijbcp/article/view/3051/2251
Hypoglycemic, Antioxidant and Hepatoprotective Activities of Ethanolic Root Bark Extract of Chrysophyllum albidum in Alloxan...Hypoglycemic, Antioxidant and Hepatoprotective Activities of Ethanolic Root Bark Extract of Chrysophyllum albidum in Alloxan...
Antioxidant and Hepatoprotective Activities of Ethanolic Root Bark Extract of Chrysophyllum albidum in Alloxan-Induced Diabetic ... hypoglycemic_antioxidant_and_hepatoprotective_activities_of_ethanolic_root_bark_extract_of_chrysophyllum_albidum_in_alloxan- ... injection of 140mg/kg of Alloxan after an overnight fast. Group A served as the normal control while. Group B served as the ... HYPOGLYCEMIC, ANTIOXIDANT AND HEPATOPROTECTIVE ACTIVITIES OF ETHANOLIC ROOT BARK EXTRACT OF CHRYSOPHYLLUM ALBIDUM IN ALLOXAN- ...
https://www.edouniversity.edu.ng/oer/journal/hypoglycemic_antioxidant_and_hepatoprotective_activities_of_ethanolic_root_bark_extract_of_chrysophyllum_albidum_in_alloxan-induced_diabetic_rats
Horsetail: MedlinePlus SupplementsHorsetail: MedlinePlus Supplements
Antidiabetic effect of Equisetum giganteum L. extract on alloxan-diabetic rabbit. J Ethnopharmacol. 2020;260:112898. View ...
https://medlineplus.gov/druginfo/natural/843.html
Hypoglycemic and Hypolipidemic Activities of Terminalia arjuna Stem Bark in Alloxan Induced Diabetic Rats | Ragavan | Journal...Hypoglycemic and Hypolipidemic Activities of Terminalia arjuna Stem Bark in Alloxan Induced Diabetic Rats | Ragavan | Journal...
Hypoglycemic and Hypolipidemic Activities of Terminalia arjuna Stem Bark in Alloxan Induced Diabetic Rats ... Results: Significant reduction in glucose and lipid profile in serum and tissues of alloxan induced diabetic rats was noticed, ... Oral administration of the Terminalia arjuna stem bark extract daily at a dose of 250 and 500 mg/kg body weight to alloxan ... liver and adipose tissue in alloxan induced diabetic rats. Methods: ...
https://www.i-scholar.in/index.php/jnr/article/view/28219/24455
SciELO - Brazil - Syzygium cumini and the regeneration of insulin positive cells from the pancreatic duct Syzygium cumini and...SciELO - Brazil - Syzygium cumini and the regeneration of insulin positive cells from the pancreatic duct Syzygium cumini and...
MATHEUS, C. E.; LEITER, E. H. Constitutive differences in antioxidant defense status distinguish alloxan-resistant and alloxan- ... Contrasting effect of alloxan on islets and single mouse pancreatic beta-cells. Biochemical Journal, v. 1, n. 352, p. 398-397, ... Alloxan can specifically destroy the beta (b) cells of the pancreatic islets, inducing loss of the cell turgor, nuclear ... After a 24 hours fasting period the animals received 150mg/kg of alloxan (Sigma-Aldrich Inc, St Louis, MO, USA, in a 2% ...
https://www.scielo.br/j/bjvras/a/BR7nntHCPQvD9hN99qRNGqJ/?lang=en
Proceedings - Section A | Indian Academy of SciencesProceedings - Section A | Indian Academy of Sciences
Alloxan. ; First Order Reaction. ; Nitric Acid Solution. * Abstract. The decomposition of murexide in acidic solutions was ...
https://www.ias.ac.in/describe/article/seca/044/01/0046-0052
HYPOLIPIDEMIC AND ANTIOXIDANT CAPACITY OF METHANOL LEAF EXTRACT OF KIGELIA AFRICANA IN ALLOXAN INDUCED DIABETIC ALBINO RATS |...HYPOLIPIDEMIC AND ANTIOXIDANT CAPACITY OF METHANOL LEAF EXTRACT OF KIGELIA AFRICANA IN ALLOXAN INDUCED DIABETIC ALBINO RATS |...
Alloxan was induced into 15 male wister albino rats and 5 male wister albino rats were used for the normal control group. They ... 7. THE EFFECT OF METHANOLIC EXTRACT OF UNRIPE Carica papaya ON ELECTROLYTE PROFILE OF ALLOXAN INDUCED DIABETIC RAT1 OBINNA ... 8. THE EFFECT OF METHANOLIC EXTRACT OF UNRIPE Carica papaya ON ELECTROLYTE PROFILE OF ALLOXAN INDUCED DIABETIC RAT1 OBINNA ... 4. EFFECT OF Solanum macrocarpon AND ANTI-DIABETIC DRUG GLIBENCLIMIDE ON SOME BLOOD PARAMETERS OF ALLOXAN INDUCED DIABETIC RATS ...
https://www.grossarchive.com/project/bio-chemistry/18737-hypolipidemic-and-antioxidant-capacity-of-methanol-leaf-extract-of-kigelia-africana-in-alloxan-induced-diabetic-albino-rats
Serum Biochemical Changes in Alloxan-induced Diabetic Rats and Ameliorative Effects of Moringa oleifera and Morinda lucida Leaf...
Serum Biochemical Changes in Alloxan-induced Diabetic Rats and Ameliorative Effects of Moringa oleifera and Morinda lucida Leaf ... Rats in groups 1-6 were made diabetic via a single injection of alloxan monohydrate (160 mg/kg i.p). Animals whose blood ... Abd El Latif, A., El Bialy Bel S., Mahboub, H.D., AbdEldaim, M.A. (2014). Moringaoleifera leaf extract ameliorates alloxan- ... Serum Biochemical Changes in Alloxan-induced Diabetic Rats and Ameliorative Effects of Moringa oleifera and Morinda lucida Leaf ...
https://jurnal.ugm.ac.id/TradMedJ/article/view/69945
Effect of Muntingia calabura L. Leaf Extract on Blood Glucose Levels and Body Weight of Alloxan-Induced Diabetic Mice |...Effect of Muntingia calabura L. Leaf Extract on Blood Glucose Levels and Body Weight of Alloxan-Induced Diabetic Mice |...
Effect of Muntingia calabura L. Leaf Extract on Blood Glucose Levels and Body Weight of Alloxan-Induced Diabetic Mice. Primary ... Objective: To evaluate the effect of Muntingia calabura L. leaf extract on the blood glucose level and weight of alloxan- ... Solikhah TI, Solikhah GP. Effect of Muntingia calabura L. Leaf Extract on Blood Glucose Levels and Body Weight of Alloxan- ... Effect of Muntingia calabura L. Leaf Extract on Blood Glucose Levels and Body Weight of Alloxan-Induced Diabetic Mice. * ...
https://www.phcogj.com/article/1686
Assessment of the Histopathological Changes Occurring in the Testis of the Mice Suffering from Experimental Diabetes Induced...Assessment of the Histopathological Changes Occurring in the Testis of the Mice Suffering from Experimental Diabetes Induced...
Keywords: Alloxan, diabetes, testis, Helichrysum plicatum DC, Tanacetum balsamita L., mouse, histopathology, TUNEL, ... on the histopathology of the testicles of the mice that had alloxan-induced type 1 diabetes or with imitated physiopathology of ... of the Histopathological Changes Occurring in the Testis of the Mice Suffering from Experimental Diabetes Induced Using Alloxan ...
https://avesis.yyu.edu.tr/yayin/833f7712-4575-474e-9ab9-386d6ddaddec/assessment-of-the-histopathological-changes-occurring-in-the-testis-of-the-mice-suffering-from-experimental-diabetes-induced-using-alloxan
Streptozocin a-anomer = 75 , = 98 HPLC, powder 18883-66-4Streptozocin a-anomer = 75 , = 98 HPLC, powder 18883-66-4
Streptozocin (N-(Methylnitrosocarbamoyl)-α-D-glucosamine ); α-anomer |= 75%, |= 98% HPLC, powder; Streptozocin or streptozotocin is used to induce type 1 diabetes for medical research; Streptozocin or streptozotocin, is obtained from Streptomyces achromogenes; An N-nitroso-containing c
https://www.sigmaaldrich.com/GB/en/product/sigma/s0130
African Journal of Biochemistry Research - November, 2009 editionAfrican Journal of Biochemistry Research - November, 2009 edition
The effect of Gongronema latifolium on serum cardiac enzymes in alloxan induced diabetic rat models and normal control rats ... Effect of Gongronema latifolium crude leaf extract on some cardiac enzymes of alloxan-induced diabetic rats ...
https://academicjournals.org/journal/AJBR/edition/November,_2009
Scientia Pharmaceutica | An Open Access Journal from MDPIScientia Pharmaceutica | An Open Access Journal from MDPI
Forty alloxan-induced diabetic Wistar rats were divided into eight groups. The different groups were administered daily with ... Orally Administered Prosochit®-Based Nanoparticles of Insulin Ameliorates Alloxan-Induced Diabetes in Rats by Emmanuel O. ...
https://www.mdpi.com/journal/scipharm?id=1403
Mendel Friedman : USDA ARSMendel Friedman : USDA ARS
Anti-diabetic effects of rice hull smoke extract in alloxan-induced diabetic mice - (Peer Reviewed Journal) ... Anti-diabetic effects of rice hull smoke extract in alloxan-induced diabetic mice. Journal of Agricultural and Food Chemistry. ...
https://www.ars.usda.gov/people-locations/person/?person-id=1853
The effects of corn silk on glycaemic metabolism | Nutrition & Metabolism | Full TextThe effects of corn silk on glycaemic metabolism | Nutrition & Metabolism | Full Text
Also, the body weight of the alloxan-induced hyperglycemic mice was increased gradually. However, ascension of blood glucose ... The alloxan-damaged pancreatic β-cells of the mice were partly recovered gradually after the mice were administered with corn ... the blood glucose and the HbA1c were significantly decreased in alloxan-induced hyperglycemic mice (p < 0.05, p < 0.01, ... Although corn silk extract increased the level of hepatic glycogen in the alloxan-induced hyperglycemic mice, there was no ...
https://nutritionandmetabolism.biomedcentral.com/articles/10.1186/1743-7075-6-47/tables/3
RatsMonohydrateDiabetes MellitusExtractMiceInsulinEffectInjectionOralExperimentalResults
Rats18
  • This study aims to examine the effects of flax and pumpkin powder seed mixture on alloxan induced diabetes in Wistar rats. (nih.gov)
  • The effects of the extract on the haematological and some biochemical parameters of alloxan-induced diabetic rats were investigated. (scirp.org)
  • Therefore, the present study was undertaken to provide information on the restorative effects of dichloromethane/methanol (1:1) extract of N. laevis leaves on alloxan-induced diabetic rats using biochemical indices of the liver and kidney functions as well as haematological parameters. (scirp.org)
  • Alloxan-induced diabetic rats were treated with insulin (i.p.) or with Capparis decidua powder as a hypoglycaemic agent mixed with diet. (iisc.ac.in)
  • A single oral dose of 250, 500 and 1000 mg/kg of the extract was evaluated for hypoglycemic activity in a glucose tolerance test in normal rats and for antihyperglycemic activity in alloxan-induced (140 mg/kg) diabetic rats. (una.ac.cr)
  • 0.05) blood glucose levels in alloxan induced hyperglycemic rats at 4 and 5 h. (una.ac.cr)
  • Zingebiraceae ) on serum lipid profile and on blood glucose in alloxan-induced diabetes and propylthiouracil-induced hypothyroidism in rats. (phcogres.com)
  • Objective: To study the effect of 50% ethanolic extract of Terminalia arjuna bark on glucose and lipid profile in serum, kidney, liver and adipose tissue in alloxan induced diabetic rats. (i-scholar.in)
  • Methods: Oral administration of the Terminalia arjuna stem bark extract daily at a dose of 250 and 500 mg/kg body weight to alloxan induced diabetic rats for a period of 30 days. (i-scholar.in)
  • Results: Significant reduction in glucose and lipid profile in serum and tissues of alloxan induced diabetic rats was noticed, the extract even under high concentration (500 mg/kg body weight) showed no toxic effect in control rats. (i-scholar.in)
  • Alloxan was induced into 15 male wister albino rats and 5 male wister albino rats were used for the normal control group. (grossarchive.com)
  • This research project studied the effect of ethanolic leaf extract of Dialium guineense Willd (Fabaceae) on oral glucose tolerance in mice and alloxan-induced diabetic female rats. (grossarchive.com)
  • This study investigated the effects of Eucalyptus globules on alloxan -induced diabetic rats. (grossarchive.com)
  • Diabetes mellitus commonly known as diabetes is a group of metabolic disorder characterized by high blood sugar level over a prolonged period (WHO,2014) This research is aimed at investigating effect of solanum macrocapon and Anti-diabetic drug glibenclamide on some blood parameters of alloxan induced diabetic rats. (grossarchive.com)
  • The effect of Gongronema latifolium on serum cardiac enzymes in alloxan induced diabetic rat models and normal control rats were determined using graded doses of 80% ethanol extract of G. latifolium leaf. (academicjournals.org)
  • of artichoke on the changes of serum glucose, lipids and lipoproteins in ALLOXAN MONOHYDRATE -induced diabetic rats was investigated. (sid.ir)
  • Screening and comparison of the antidiabetic properties of Phylanthus niruri in alloxan-induced rats. (iium.edu.my)
  • Alloxan induced diabetic rats were post treated with plant extracts (150 mg/kg) and serum samples were colle. (researcherslinks.com)
Monohydrate4
  • I present diabetes study was induced in albino rat models with the alloxan monohydrate. (pharmacognosyjournal.in)
  • Second group (diabetic), received 120 mg/kgbw ALLOXAN MONOHYDRATE . (sid.ir)
  • Fourth group (diabetic + Cynara scolymus) at first became diabetic by ALLOXAN MONOHYDRATE injection, then they received 300 mg/kgbw hydroalcoholic plant extract. (sid.ir)
  • The objective of this work is to study the effect of Clerodendrum formicarum (100, 150 and 200 mg/kg body weight) on astrocytes and microglial cells in a model of diabetic neuropathic pain induced by alloxan monohydrate (150 mg/kg). (scirp.org)
Diabetes Mellitus2
  • Alloxan, a diabetogenic compound, is used to induce type 1 diabetes mellitus in animals. (greenmedinfo.com)
  • RW may be useful in preventing alloxan-induced type 1-diabetes mellitus. (greenmedinfo.com)
Extract4
  • Assessment of the antidiabetic potential of extract and novel phytoniosomes formulation of Tradescantia pallida leaves in the alloxan-induced diabetic mouse model. (bvsalud.org)
  • The leaves extract and phytoniosomes of T. pallida in doses of 15, 25 and 50 mg/kg were used to assess the oral glucose loaded, and alloxan -induced diabetic mice models. (bvsalud.org)
  • To evaluate the effect of Muntingia calabura L. leaf extract on the blood glucose level and weight of alloxan-induced diabetic mice. (phcogj.com)
  • M. calabura leaf extract had a significant antidiabetic effect that can normalize the weight of alloxan-induced diabetic mice. (phcogj.com)
Mice2
  • The mice were injected using 150mg/kg of alloxan intraperitoneally to induce diabetes. (phcogj.com)
  • In this study, we aimed to examine the effect of volatile oil extracts of Helichrysum plicatum DC (HP) and Tanacetum balsamita L. (TB) on the histopathology of the testicles of the mice that had alloxan-induced type 1 diabetes or with imitated physiopathology of type 2 diabetes. (yyu.edu.tr)
Insulin4
  • Alloxan-treated HIT-T15 cells exhibited lowered viability, increased intracellular ROS levels, elevated cytosolic free Ca(2+) concentration, DNA fragmentation, decreased intracellular ATP levels and lowering of glucose-stimulated release of insulin. (greenmedinfo.com)
  • RW completely prevented the generation of alloxan-induced ROS, increase of cytosolic Ca(2+) concentration, decrease of intracellular ATP level, and lowering of glucose-stimulated insulin release, and strongly blocked DNA fragmentation, partially suppressing the lowering of viability of alloxan-treated cells. (greenmedinfo.com)
  • The insulin, glucose and cholesterol level and activity of lysosomal enzymes in the course of the model alloxan diabetes. (nel.edu)
  • Witek B, Król T, Kołataj A, Ochwanowska E, Stanisławska I, Slewa A. The insulin, glucose and cholesterol level and activity of lysosomal enzymes in the course of the model alloxan diabetes. (nel.edu)
Effect2
  • Protective mechanism of reduced water against alloxan-induced pancreatic beta-cell damage: Scavenging effect against reactive oxygen species. (greenmedinfo.com)
  • Overall, administration of DME has significant ameliorative effect on alloxan-induced anaemia and other haematological alterations in diabetes and this may be of immense benefits in the management of diabetes and its associated haematological complications. (scirp.org)
Injection1
  • Blood glucose level was tested before alloxan injection and 5 days after injection to confirm diabetes development. (phcogj.com)
Oral1
  • Se evaluó la actividad hipoglucémica de una dosis oral única de 250, 500 y 1000 mg/kg del extracto en una prueba de tolerancia a la glucosa en ratas normales y la actividad antihiperglucémica en ratas diabéticas inducidas por aloxano (140 mg/kg). (una.ac.cr)
Experimental1
  • IMSEAR at SEARO: Experimental diabetes in guineapigs by alloxan. (who.int)
Results1
  • These results suggest that RW protects pancreatic beta-cells from alloxan-induced cell damage by preventing alloxan-derived ROS generation. (greenmedinfo.com)
Alloxan Monohydrate_About HighFine
Alloxan Monohydrate_About HighFine (en.highfine.com)
PDF] Aphrodisiac Property of the Elephant Creeper Argyreia nervosa | Semantic Scholar
PDF] Aphrodisiac Property of the Elephant Creeper Argyreia nervosa | Semantic Scholar (semanticscholar.org)
Cola de Caballo: MedlinePlus suplementos
Cola de Caballo: MedlinePlus suplementos (medlineplus.gov)
Diabetes Mellitus: Type 2: Prevention | GreenMedInfo | Disease
Diabetes Mellitus: Type 2: Prevention | GreenMedInfo | Disease (greenmedinfo.com)
Trpm7 (transient receptor potential cation channel, subfamily M, member 7) - Rat Genome Database
Trpm7 (transient receptor potential cation channel, subfamily M, member 7) - Rat Genome Database (rgd.mcw.edu)
Scientia Pharmaceutica | An Open Access Journal from MDPI
Scientia Pharmaceutica | An Open Access Journal from MDPI (mdpi.com)
Beneficial effects of L-arginine nitric oxide-producing pathway in
Beneficial effects of L-arginine nitric oxide-producing pathway in (greenmedinfo.com)
The effects of corn silk on glycaemic metabolism | Nutrition & Metabolism | Full Text
The effects of corn silk on glycaemic metabolism | Nutrition & Metabolism | Full Text (nutritionandmetabolism.biomedcentral.com)
FARMACIA Y BIOQUIMICA - Research output - San Luis Gonzaga National University of Ica
FARMACIA Y BIOQUIMICA - Research output - San Luis Gonzaga National University of Ica (cris.unica.edu.pe)
Begriffe mit A | Medizin-Lexikon | gesundheit.de
Begriffe mit A | Medizin-Lexikon | gesundheit.de (gesundheit.de)
Burdock root: Benefits, side effects, and uses
Burdock root: Benefits, side effects, and uses (medicalnewstoday.com)
(sid.ir)
Frontiers | Effects of Nigella sativa, Camellia sinensis, and Allium sativum as Food Additives on Metabolic Disorders, a...
Frontiers | Effects of Nigella sativa, Camellia sinensis, and Allium sativum as Food Additives on Metabolic Disorders, a... (frontiersin.org)
Molecules | Free Full-Text | Intracellular Hydrolysis of Small-Molecule O-Linked N-Acetylglucosamine Transferase Inhibitors...
Molecules | Free Full-Text | Intracellular Hydrolysis of Small-Molecule O-Linked N-Acetylglucosamine Transferase Inhibitors... (mdpi.com)
Essential Oils and Their Constituents as Anticancer Agents: A Mechanistic View
Essential Oils and Their Constituents as Anticancer Agents: A Mechanistic View (hindawi.com)
Molecules | Free Full-Text | Interactive Effects of Light and Melatonin on Biosynthesis of Silymarin and Anti-Inflammatory...
Molecules | Free Full-Text | Interactive Effects of Light and Melatonin on Biosynthesis of Silymarin and Anti-Inflammatory... (mdpi.com)
Therapeutic Injections for Pain Management: Types of Therapeutic Injections, Guidelines for Therapeutic Application, Technical...
Therapeutic Injections for Pain Management: Types of Therapeutic Injections, Guidelines for Therapeutic Application, Technical... (medscape.com)
Diabetes | Fucoidan | Antioxidant Enzymes | Free Radicals | Superoxide Dismutase | Catalase | Glutathione Peroxidase |...
Diabetes | Fucoidan | Antioxidant Enzymes | Free Radicals | Superoxide Dismutase | Catalase | Glutathione Peroxidase |... (ijpsonline.com)
Vol. 2 No. 1 (2010) | Journal of Scientific Research
Vol. 2 No. 1 (2010) | Journal of Scientific Research (banglajol.info)
WHO EMRO | Diabetes knowledge, beliefs and practices among people with diabetes attending a university hospital in Karachi,...
WHO EMRO | Diabetes knowledge, beliefs and practices among people with diabetes attending a university hospital in Karachi,... (emro.who.int)
Rutgers Cancer Institute of New Jersey - Health Library
Rutgers Cancer Institute of New Jersey - Health Library (healthlibrary.epnet.com)