Ninhydrin
Diabetes Mellitus, Experimental
Islets of Langerhans
Irregular microscopic structures consisting of cords of endocrine cells that are scattered throughout the PANCREAS among the exocrine acini. Each islet is surrounded by connective tissue fibers and penetrated by a network of capillaries. There are four major cell types. The most abundant beta cells (50-80%) secrete INSULIN. Alpha cells (5-20%) secrete GLUCAGON. PP cells (10-35%) secrete PANCREATIC POLYPEPTIDE. Delta cells (~5%) secrete SOMATOSTATIN.
Glycosuria
Accelerated intimal hyperplasia and increased endogenous inhibitors for NO synthesis in rabbits with alloxan-induced hyperglycaemia. (1/243)
1. We examined whether endogenous inhibitors of NO synthesis are involved in the augmentation of intimal hyperplasia in rabbits with hyperglycaemia induced by alloxan. 2. Four weeks after the endothelial denudation of carotid artery which had been performed 12 weeks after alloxan, the intimal hyperplasia was greatly augmented with hyperglycaemia. The degree of hyperplasia was assessed using three different parameters of histopathological findings as well as changes in luminal area and intima: media ratio. 3. There were positive and significant correlations between intima:media ratio, plasma glucose, and concentrations of N(G)-monomethyl-L-arginine (L-NMMA) and N(G), N(G)-dimethyl-L-arginine (ADMA) in endothelial cells, that is, the intima:media ratio became greater as plasma glucose and endothelial L-NMMA and ADMA were increased. Furthermore, endothelial L-NMMA and ADMA were increased in proportion to the increase in plasma glucose. 4. In contrast, there were inverse and significant correlations between cyclic GMP production by carotid artery strips with endothelium and plasma glucose, between cyclic GMP production and endothelial L-NMMA and ADMA, and between the intima:media ratio and cyclic GMP production. 5. Exogenously applied L-NMMA and ADMA inhibited cyclic GMP production in a concentration-dependent manner. IC50 values were determined to be 12.1 microM for the former and 26.2 microM for the latter. The cyclic GMP production was abolished after the deliberate removal of endothelium from the artery strips. 6. These results suggest that the augmentation of intimal hyperplasia with hyperglycaemia is closely related to increased accumulation of L-NMMA and ADMA with hyperglycaemia, which would result in an accelerated reduction in NO production/release by endothelial cells. (+info)Alloxan in vivo does not only exert deleterious effects on pancreatic B cells. (2/243)
The aim of the experiment was to investigate the mechanism of harmful alloxan action in vivo. 75 mg/kg b.w. of this diabetogenic agent were administered to fasting rats. Two minutes later the animals were decapitated. It was observed that alloxan caused a distinct rise in blood insulin and glucose levels with a concomitant drop of free fatty acids. The amount of sulfhydryl groups in the liver of alloxan-treated rats was decreased and glutathione peroxidase activity was substantially higher. These results indicate that some changes observed in alloxan-induced diabetes can not only be the consequence of B cells damage by alloxan but may also be the result of its direct influence on other tissues. It was also observed that glucose given 20 min before alloxan injection only partially protected against the deleterious effects of alloxan. (+info)Intercalated duct cells in the chicken pancreatic islet with special reference to the alloxan administration. (3/243)
The intercalated duct cells were observed in the A and B islets of the chicken pancreas. These cells adhered with each other by intercellular junctional complexes at the apical side. They had many microvilli projecting into the lumen. Abluminally, they displayed extended slender cytoplasmic processes between islet endocrine cells. Administration of alloxan resulted to denser cytoplasm and a more prominent thickening of cytoplasmic processes of the intercalated duct cells, although the blood glucose levels did not show appreciable changes by the treatment. The intercalated duct epithelial cells appeared clearly as stellate cells. The lysosomes increased in size and number with passage of time after alloxan administration. The present findings may suggest that intercalated ducts are not only anatomically important as a structure passing through the islet but also play physiologically by protecting the islet endocrine cells. (+info)Reduced coronary NO production in conscious dogs after the development of alloxan-induced diabetes. (4/243)
The role of nitric oxide (NO) in the control of coronary blood flow (CBF) during the development of diabetes is unknown. To study this, mongrel dogs were chronically instrumented using sterile techniques for measurements of systemic hemodynamics and CBF. With heart rate controlled (150 beats/min), veratrine (1-10 micrograms/kg) caused dose-dependent increases in CBF; e.g., 5 mirograms/kg of veratrine increased CBF by 57 +/- 7% from 41 +/- 1.3 ml/min (P < 0.05). The dogs developed diabetes 4-5 wk after injection of alloxan (40-60 mg/kg iv, blood glucose levels were 384 +/- 18 mg/dl). After diabetes the same doses of veratrine caused smaller increases in CBF; i.e., 5 micrograms/kg of veratrine increased CBF by 32 +/- 2% (P < 0.05 compared with control) from 28 +/- 4 ml/min. ACh- and adenosine-induced coronary vasodilation were reduced after diabetes as well. In anesthetized dogs after diabetes, vagal stimulation caused smaller increases in CBF. ACh and bradykinin caused smaller increases in NO(-)(2) production in coronary microvessels from diabetic dogs. Furthermore, despite the fact that mRNA for endothelial cell NO synthase from the aorta was increased twofold with the use of Northern blotting, the protein for aortic endothelial constitutive NO synthase was reduced by 66% after diabetes, as determined by Western blotting. Our results indicate that the NO-dependent coronary vasodilation by the Bezold-Jarisch reflex is impaired in conscious dogs after diabetes. The mechanism responsible for the impaired endothelium-dependent coronary vasodilation is most likely the decreased release of NO from the endothelium. (+info)Supplementation of N-acetylcysteine inhibits NFkappaB activation and protects against alloxan-induced diabetes in CD-1 mice. (5/243)
Reactive oxygen species (ROS) are involved in the destruction of pancreatic beta cells and the development of insulin-dependent diabetes mellitus (IDDM). However, the cellular mechanism responsible for beta cell death is still unclear. We hypothesize that activation of NFkappaB by ROS is the key cellular signal in initiating a cascade of events leading to beta cell death. Thus, enhancement of pancreatic GSH, a known antioxidant and key regulator of NF-kappaB, should protect against IDDM. Weanling CD1 mice (n=5) were injected with alloxan (50 mg/kg i.v.) to induce IDDM. Using EPR spin trapping techniques, we demonstrated that alloxan generated ROS in the pancreas 15 min after administration. Activation of NFkappaB in pancreatic nuclear extracts was observed 30 min after alloxan injection, as assessed by an electrophoretic mobility shift assay. Fasting blood glucose levels were monitored for 14 days. Supplementation with N-acetylcysteine (NAC, 500 mg/kg), a GSH precursor, inhibited alloxan-induced NFkappaB activation and reduced hyperglycemia. Thus, NFkappaB activation by ROS may initiate a sequence of events leading to IDDM. Inhibition of NF-kappaB activation by NAC attenuated the severity of IDDM. This research will contribute to the understanding of the etiology of IDDM and may lead to the development of better strategies for disease prevention. (+info)Lipolysis induced by alloxan in rat adipocytes is not inhibited by insulin. (6/243)
Isolated rat adipocytes were incubated with adrenaline, adrenaline plus insulin, alloxan or alloxan plus insulin. Glycerol release was taken as a measure of lipolysis. It was observed that alloxan in the concentration of 3, 10 and 20 mmol/l intensifies lipolysis in adipocytes in the absence of adrenaline. Insulin (10(-6) mol/l) treatment of cells did not inhibit lipolysis caused by this compound, but significantly restricted lipolysis induced by adrenaline (10(-6) mol/l). It was also shown that alloxan in the concentration of 3 and 10 mmol/l intensified lipolysis stimulated by adrenaline (10(-6) mol/l). Addition of 20 mmol/l of alloxan strongly inhibited glycerol release in the presence of adrenaline. The results presented here clearly indicate that the action of alloxan concerns cells of the white adipose tissue. (+info)Resistance of ALR/Lt islets to free radical-mediated diabetogenic stress is inherited as a dominant trait. (7/243)
ALS/Lt and ALR/Lt are inbred mouse strains selected for susceptibility and resistance to alloxan (AL)-induced diabetes. Within 24-h after AL administration in vivo, ALS/Lt islets were distinguished from ALR/Lt islets by more extensive necrotic changes. Within 7 days post-AL, ALS/Lt mice exhibited hyperglycemia and hypoinsulinemia, whereas ALR/Lt mice maintained normal plasma insulin and glucose levels. We have recently shown that resistance in ALR/Lt correlated with constitutively elevated systemic (and pancreatic) free radical defense status. In the present report, we examined whether ability to detoxify free radical stress extended to the level of ALR/Lt pancreatic islets. Cultured ALS/Lt islets exposed for 5 min to increasing (0-3 mmol/l) AL concentrations in vitro exhibited an 80% decline in numbers of intact islets after a subsequent 6-day culture period, as well as a 75% reduction in islet insulin content and a 94% decrease in glucose-stimulated insulin secretory capacity. In contrast, ALR/Lt islets remained viable and retained glucose-stimulated insulin secretory capacity as well as normal insulin content. This ALR/Lt islet resistance extended to hydrogen peroxide, a free radical generator whose entry into beta-cells is not dependent on glucose transporters. The elevated antioxidant defenses previously found in ALR/Lt pancreas were extended to isolated islets, which exhibited significantly higher glutathione and Cu-Zn superoxide dismutase 1 levels compared with ALS/Lt islets. A dominant genetic trait from ALR/Lt controlling this unusual AL resistance was indicated by the finding that reciprocal F1 mice of both sexes were resistant to AL administration in vivo. A backcross to ALS/Lt showed 1:1 segregation for susceptibility/resistance, indicative of a single gene controlling the phenotype. In conclusion, the ALR/Lt mouse may provide important insight into genetic mechanisms capable of rendering islets strongly resistant to free radical-mediated damage. (+info)Protective mechanism of glucose against alloxan-induced beta-cell damage: pivotal role of ATP. (8/243)
Glucose prevents the development of diabetes induced by alloxan. In the present study, the protective mechanism of glucose against alloxan-induced beta-cell damage was investigated using HIT-T 15 cell, a Syrian hamster transformed beta-cell line. Alloxan caused beta-cell damages with DNA fragmentation, inhibition of glucose-stimulated insulin release, and decrease of cellular ATP level, but all of these beta-cell damages by alloxan were prevented by the presence of 20 mM glucose. Oligomycin, a specific inhibitor of ATP synthase, completely abolished the protective effects of glucose against alloxan-induced cell damage. Furthermore, treatment of nuclei isolated from HIT-T15 cells with ATP significantly prevented the DNA fragmentation induced by Ca2+. The results indicate that ATP produced during glucose metabolism plays a pivotal role in the protection of glucose against alloxan-induced beta-cell damage. (+info)
Superoxide dismutase-inhibitible reduction of cytochrome c by the alloxan radical. Implications for alloxan cytotoxicity |...
Effects of Diabetes Mellitus Induced by Alloxan on the Pharmacokinetics of Metformin in Rats: Restoration of Pharmacokinetic...
Activation of a novel non-selective cation channel by alloxan and H2O2 in the rat insulin-secreting cell line CRI-G1<...
THE EFFECT OF INSULIN, ALLOXAN DIABETES, AND ANOXIA ON THE ULTRASTRUCTURE OF THE RAT HEART | Journal of Cell Biology |...
Alloxan Monohydrate Manufacturers, Suppliers, Exporters, Dealers in Sangli, India
Postoperative changes in the lipid content of the liver, placenta and embryo of normal, alloxan diabetic and insulin-treated...
Fatty acid composition and lipid peroxidation in brain microsomes of albino rats with alloxan diabetes
Internet Scientific Publications
IJPBS Article- DIFFERENTIAL EFFECTS OF ALLOXAN ON DIFFERENT BLOOD PARAMETERS IN DIABETEC INDUCED MALE WISTAR RATS
Hypoglycemic Activity And Regeneration Of Pancreatic Beta-cells Produced By Allium Cepa In Alloxan-induced Diabetic Rats
The use of alloxan and streptozotocin in experimental diabetes models / Deneysel Diyabet Modellerinde Alloksan ve...
The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas.
Blog of Pure Puer Tea » Oral administration of puerh tea polysaccharides lowers blood glucose levels and enhances antioxidant...
Apitherapy News: Propolis May Protect Against Damage Caused by Diabetes
NEWBOULDIA LAEVIS LEAF FACILITATES INSULIN SECRETION, GLUCOSE UPTAKE AND PANCREATIC FUNCTION IN ALLOXAN-INDUCED HYPERGLYCAEMIA...
Effects of long-term diabetes on the structure and cell proliferation of the myometrium in the early pregnancy of mice. -...
Health Arena: Beware of White Processed Foods
Serum Lipase and Alloxan Diabetes in Rats | Science
Journal of Biosciences | Indian Academy of Sciences
Nonenzymatic Glucosylation of Serum Proteins and Hemoglobin: Response by J W. Baynes
Pre-diabetic Clinical Changes Induced by Low Doses of Alloxan-Streptozotocin Cocktail in Rabbits
HYPOLIPIDEMIC AND ANTIOXIDANT CAPACITY OF METHANOL LEAF EXTRACT OF KIGELIA AFRICANA IN ALLOXAN INDUCED DIABETIC ALBINO RATS
Coach Kevin Dineen: 10-Pack of Nutrition and Fitness Facts
Nigerian Propolis May Help Treat Diabetes
Suppression of aging process (part 2) - Suppressing the incidence of diabetic symptoms
Browsing by Subject Azadirachta indica J, antihyperglycaemic, alloxan, ethanol extract
Effect of ficus relegiosa on blood glucose and total lipid levels of normal and alloxan diabetic rabbits. | CureHunter
Hypoglycemic effect of Nyctanthes arbor-tristis leaf extract on Alloxan induced Diabetic rabbits
The effect of alloxan-induced diabetes on anti-nociception and on the development of morphine tolerance and dependence in rats
Histomorphometric evaluation of bone regeneration using autogenous bone and beta-tricalcium phosphate in diabetic rabbits
Hypoglycemic and antilipidemic properties of kombucha tea in alloxan-induced diabetic rats | BMC Complementary and Alternative...
Guarana (Paullinia cupana) consumption improves hepatic and renal parameters in alloxan-induced diabetic rats
Improvement of Dissolution Rate of Gliclazide Using Solid Dispersions with Aerosil 380 and Its Effect on Alloxan Induced...
Plus it
Anti-diabetic Activity Of Polyherbal Formulation Containing Some Bitter Plant Constituents In Alloxan Induced Diabetic Rats
RJPT - Anti-Diabetic Activity of Aqueous Extract of Leaves of Pavonia zeylanica in Rats
Dokument bez názvu
ALLOXAN IN THE TREATMENT OF A CASE OF ISLET CELL CARCINOMA OF THE PANCREAS WITH LIVER METASTASES* | Annals of Internal Medicine...
Clinical use and time relationship of changes in affinity measurement of glycosylated albumin and glycosylated hemoglobin<...
Alloxan - Everything2.com
Increase in T cell surface thiol levels are linked with activation and diabetogenicity | The Journal of Immunology
Fast exocytosis with few Ca(2+) channels in insulin-secreting mouse pancreatic B cells. - Radcliffe Department of Medicine
Pancreatic B Cell Function in Motor Neurone Disease | Clinical Science | Portland Press
PHARMACEUTICAL COMPOSITIONS BASED ON A MICROEMULSION - Patent application
This therapeutic approach is relatively simple in regard o - joketree icu
DI-fusion Protective effect of schisanhenol against alloxan-induced...
EFFECT OF DEHYDROASCORBIC ACID ON THE ISLETS OF LANGERHANS OF THE RAT PANCREAS | JCB
think loud: sound scientific reason to avoid pizzas and parathas
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Alloxan
... , sometimes referred to as alloxan hydrate, is the name of the organic compound with the formula OC(N(H)CO)2C(OH)2. It ... The name "Alloxan" emerged from an amalgamation of the words "allantoin" and "Oxalsäure" (oxalic acid). The alloxan model of ... Studies suggests that alloxan does not cause diabetes in humans. Others found a significant difference in alloxan plasma levels ... A dimeric derivative alloxantin can be prepared by partial reduction of alloxan with hydrogen sulfide. Alloxan is a toxic ...
Passiflora glandulosa
in alloxan-induced diabetic mice". World Journal of Pharmacy and Pharmaceutical Sciences. 4: 1571-1586 - via Research Gate.{{ ...
Stevia rebaudiana
Bertoni) on alloxan-induced diabetic rats". J Pharm Bioallied Sci. 3 (2): 242-8. doi:10.4103/0975-7406.80779. PMC 3103919. PMID ...
Stevia (genus)
Bertoni) on alloxan-induced diabetic rats". Journal of Pharmacy and Bioallied Sciences. 3 (2): 242-248. doi:10.4103/0975- ...
Momordica cymbalaria
Fruit powder in alloxan-diabetic rats". Journal of Ethnopharmacology. 67 (1): 103-109. doi:10.1016/S0378-8741(99)00004-5. PMID ...
Streptozotocin
Alloxan Brentjens R, Saltz L (2001). "Islet cell tumors of the pancreas: the medical oncologist's perspective". Surg Clin North ... Szkudelski T (2001). "The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas". Physiol Res. 50 (6): ... "Comparison of metabolic abnormalities in diabetes mellitus induced by streptozotocin or by alloxan". Lancet. 1 (7544): 670-1. ...
Solanum anguivi
Fruit in alloxan-induced diabetic Rats". South African Journal of Botany. 88: 56-61. doi:10.1016/j.sajb.2013.04.010. ...
Stevia
Bertoni) on alloxan-induced diabetic rats". J Pharm Bioallied Sci. 3 (2): 242-248. doi:10.4103/0975-7406.80779. PMC 3103919. ...
Pleurotus pulmonarius
with Glyburide in Alloxan Induced Diabetic Mice". Evidence-Based Complementary and Alternative Medicine. 5 (2): 159-164. doi: ... and reduced the mortality of alloxan induced diabetic mice by approximately 50%. It showed a synergistic effect with the ...
Robert Hardin Williams
Steiner, Donald F.; Rauda, Vija; Williams, Robert H. (1961). "Severe Ketoacidosis in the Alloxan Diabetic Rat". Endocrinology. ...
Maud Menten
Menten, ML.; Janouch, M. (1946). "Changes in alkaline phosphatase of kidney following renal damage with alloxan". Proceedings ...
Murexide
It may also be prepared by digesting alloxan with alcoholic ammonia. Justus von Liebig and Friedrich Wöhler in Giessen, Germany ...
Violuric acid
It can also be produced by condensation of alloxan with hydroxylamine. as typical for forming the oxime of other carbonyl ...
Annona stenophylla
"Hypoglycemic Effects ofAnnona stenophyllaandMorus albaPlant Extracts in Alloxan-induced Diabetic Mice". Journal of Biologically ...
Taurine
... antioxidative and nephroprotective effects of taurine in alloxan diabetic rabbits". Biochimie. 91 (2): 261-270. doi:10.1016/j. ...
Artemisia pallens
On blood glucose levels in normal and alloxan-induced diabetic rats". Journal of Ethnopharmacology. 50 (1): 13-7. doi:10.1016/ ... fed hyperglycemic and alloxan-treated rabbits and rats. Davana oil is used in making perfumes of sweet and fruity fragrances. ...
Laboratory Syrian hamster
Streptozotocin or alloxan may be administered to induce chronic diabetes in hamsters. Atherosclerosis may be studied with ...
Albert Renold
He completed his MD with a thesis on diabetes caused by alloxan. After graduating from the University of Zurich, Renold was ...
Strecker degradation
Strecker, A (1862). "Notiz über eine eigenthümliche Oxydation durch Alloxan" [Notice of a curious oxidation by alloxan]. ... The original observation by Strecker involved the use of alloxan as the oxidant in the first step, followed by hydrolysis: The ...
Aegiceras corniculatum
"Antidiabetic effect of a black mangrove species Aegiceras corniculatum in alloxan-induced diabetic rats". J. Adv. Pharm. ...
Mladen Vranic
"Importance of glucagon in the control of futile cycling as studied in alloxan-diabetic dogs". Diabetologia. 30 (3): 175-182. ... reduction in pancreatic glucagon with normalization of somatostatin and decrease in insulin in normoglycemic alloxan-diabetic ...
Lannea edulis
"Antihyperglycemic and Antihyperlipidemic Effects of Aqueous Extracts of Lannea edulis in Alloxan-Induced Diabetic Rats". ...
Pomiferin
Bartosíková, L (2007). "Examination of the antioxidative and antidiabetic effect of pomiferin in alloxan-induced diabetes ...
Gymnema sylvestre
"Absence of antidiabetic and hypolipidemic effect of Gymnema sylvestre in non-diabetic and alloxan-diabetic rats". Braz. Arch. ...
Pyrimidine
Although pyrimidine derivatives such as alloxan were known in the early 19th century, a laboratory synthesis of a pyrimidine ... Grimaux, E. (1879). "Synthèse des dérivés uriques de la série de l'alloxane" [Synthesis of urea derivatives of the alloxan ... and alloxan. It is also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. ...
Purpuric acid
... is a nitrogenous acid related to barbituric acid that yields alloxan and uramil upon hydrolysis. It is noteworthy ...
Fenton's reagent
Brömme, H. J.; Mörke, W.; Peschke, E. (November 2002). "Transformation of barbituric acid into alloxan by hydroxyl radicals: ... free radical substitution Conversion of benzene into phenol by using Fenton's reagent Oxidation of barbituric acid into alloxan ...
Helicteres isora
"Antihyperglycemic and hypolipidemic effects of Helicteres isora roots in alloxan-induced diabetic rats: a possible mechanism of ...
Phosphatidylserine
... a study in alloxan-induced diabetic rats". Cell Biochemistry and Function. 26 (8): 859-865. doi:10.1002/cbf.1517. ISSN 1099- ...
Friedrich Wilhelm Hermann Delffs
... molybdate of ammonia and alloxan. In 1843, with mineralogist Johann Reinhard Blum, he proposed the name "leonhardite" for ...
Protective mechanism of reduced water against alloxan-induced
These results suggest that RW protects pancreatic beta-cells from alloxan-induced cell damage by preventing alloxan-derived ROS ... HIT-T15 from alloxan-induced cell damage. Alloxan, a diabetogenic compound, is used to induce type 1 diabetes mellitus in ... Alloxan-treated HIT-T15 cells exhibited lowered viability, increased intracellular ROS levels, elevated cytosolic free Ca(2+) ... RW completely prevented the generation of alloxan-induced ROS, increase of cytosolic Ca(2+) concentration, decrease of ...
Antidiabetic effect of flax and pumpkin seed mixture powder: effect on hyperlipidemia and antioxidant status in alloxan...
This study aims to examine the effects of flax and pumpkin powder seed mixture on alloxan induced diabetes in Wistar rats. ... This study aims to examine the effects of flax and pumpkin powder seed mixture on alloxan induced diabetes in Wistar rats. ... Antidiabetic effect of flax and pumpkin seed mixture powder: effect on hyperlipidemia and antioxidant status in alloxan ...
Biochemical and Haematological Effects of the Leaf Extract of Newbouldia laevis in Alloxan-Induced Diabetic Rats
The effects of the extract on the haematological and some biochemical parameters of alloxan-induced diabetic rats were ... Overall, administration of DME has significant ameliorative effect on alloxan-induced anaemia and other haematological ... was used to prevent the initial hypoglycemia caused by alloxan monohydrate [29] . After 3 days of alloxan treatment blood ... Alloxan monohydrate (Sigma, St. Louis, MO, USA) was used to induce diabetes in adult Wistar rats of both sexes. A freshly ...
Pasuchaca (Geranium ruizii Hieron.): A Medicinal Plant of the Geraniaceae Family with Hypoglycemic Effect on Alloxan-Induced...
IMSEAR at SEARO: Experimental diabetes in guineapigs by alloxan.
ANTIDIABETIC POTENTIAL OF MATOA BARK EXTRACT (Pometia pinnata) IN ALLOXAN-INDUCED DIABETIC MALE RAT STRAIN WISTAR (Rattus...
View of Age Susceptibility of Wistar Rats to Alloxan-Induced Diabetes: A Paradox
Action of Capparis decidua against alloxan-induced oxidative stress and diabetes in rat tissues [email protected]
Alloxan-induced diabetic rats were treated with insulin (i.p.) or with Capparis decidua powder as a hypoglycaemic agent mixed ... Yadav, P and Sarkar, S and Bhatnagar, D (1997) Action of Capparis decidua against alloxan-induced oxidative stress and diabetes ... Action of Capparis decidua against alloxan-induced oxidative stress and diabetes in rat tissues ...
Hypoglycemic activity on Putranjiva roxburghii bark. in alloxan induced diabetic rats
PDF] Aphrodisiac Property of the Elephant Creeper Argyreia nervosa | Semantic Scholar
Hypoglycemic and antihyperglycemic effect of Witheringia solanacea in normal and alloxan-induced hyperglycemic rats
Dose of 500 mg/kg of the extract significantly reduced (p , 0.05) blood glucose levels in alloxan induced hyperglycemic rats at ... Hypoglycemic and antihyperglycemic effect of Witheringia solanacea in normal and alloxan-induced hyperglycemic rats. dc. ... Hypoglycemic and antihyperglycemic effect of Witheringia solanacea in normal and alloxan-induced hyperglycemic rats. es_ES. ... los niveles de glucosa en sangre en ratas hiperglucémicas inducidas por alloxan a las 4 y 5 h. En conclusión, en el presente ...
Assessment of the antidiabetic potential of extract and novel phytoniosomes formulation of Tradescantia pallida leaves in the...
Antihyperlipidemic Effects of Ginger Extracts in Alloxan-induced Diabetes and Propylthiouracil-induced Hypothyroidism in (rats)...
Al-Noory AS, Amreen A-, Hymoor S. Antihyperlipidemic Effects of Ginger Extracts in Alloxan-induced Diabetes and ... Home / Pharmacognosy Research, Vol 5, Issue 3, Jul-Sep, 2013 / Antihyperlipidemic Effects of Ginger Extracts in Alloxan-induced ... Antihyperlipidemic Effects of Ginger Extracts in Alloxan-induced Diabetes and Propylthiouracil-induced Hypothyroidism in (rats) ... on serum lipid profile and on blood glucose in alloxan-induced diabetes and propylthiouracil-induced hypothyroidism in rats. ...
Promising anitidiabetic potential of Cuscuta reflexa leaves methanol extract in alloxan-induced diabetic rats | Clinical...
Diabetic model was developed by i.p. administration of alloxan monohydrate (120 mg/kg). Ingestion of CRME (100, 200, and 400 mg ... The antidiabetic activity of C. reflexa leaves methanol extract (CRME) was evaluated using alloxan-induced diabetes in Wistar ... The present investigation focuses on the antidiabetic potential of C. reflexa leaves methanol extract in alloxan-induced ... Furthermore, CRME notably reversed the histopathological changes that observed in alloxan-induced diabetes. Our research ...
Effect of turmeric on alloxan induced diabetes mellitus in albino rats | Padhye | International Journal of Basic & Clinical...
Hypoglycemic, Antioxidant and Hepatoprotective Activities of Ethanolic Root Bark Extract of Chrysophyllum albidum in Alloxan...
Antioxidant and Hepatoprotective Activities of Ethanolic Root Bark Extract of Chrysophyllum albidum in Alloxan-Induced Diabetic ... hypoglycemic_antioxidant_and_hepatoprotective_activities_of_ethanolic_root_bark_extract_of_chrysophyllum_albidum_in_alloxan- ... injection of 140mg/kg of Alloxan after an overnight fast. Group A served as the normal control while. Group B served as the ... HYPOGLYCEMIC, ANTIOXIDANT AND HEPATOPROTECTIVE ACTIVITIES OF ETHANOLIC ROOT BARK EXTRACT OF CHRYSOPHYLLUM ALBIDUM IN ALLOXAN- ...
Horsetail: MedlinePlus Supplements
Hypoglycemic and Hypolipidemic Activities of Terminalia arjuna Stem Bark in Alloxan Induced Diabetic Rats | Ragavan | Journal...
Hypoglycemic and Hypolipidemic Activities of Terminalia arjuna Stem Bark in Alloxan Induced Diabetic Rats ... Results: Significant reduction in glucose and lipid profile in serum and tissues of alloxan induced diabetic rats was noticed, ... Oral administration of the Terminalia arjuna stem bark extract daily at a dose of 250 and 500 mg/kg body weight to alloxan ... liver and adipose tissue in alloxan induced diabetic rats. Methods: ...
SciELO - Brazil - Syzygium cumini and the regeneration of insulin positive cells from the pancreatic duct Syzygium cumini and...
MATHEUS, C. E.; LEITER, E. H. Constitutive differences in antioxidant defense status distinguish alloxan-resistant and alloxan- ... Contrasting effect of alloxan on islets and single mouse pancreatic beta-cells. Biochemical Journal, v. 1, n. 352, p. 398-397, ... Alloxan can specifically destroy the beta (b) cells of the pancreatic islets, inducing loss of the cell turgor, nuclear ... After a 24 hours fasting period the animals received 150mg/kg of alloxan (Sigma-Aldrich Inc, St Louis, MO, USA, in a 2% ...
Proceedings - Section A | Indian Academy of Sciences
HYPOLIPIDEMIC AND ANTIOXIDANT CAPACITY OF METHANOL LEAF EXTRACT OF KIGELIA AFRICANA IN ALLOXAN INDUCED DIABETIC ALBINO RATS |...
Alloxan was induced into 15 male wister albino rats and 5 male wister albino rats were used for the normal control group. They ... 7. THE EFFECT OF METHANOLIC EXTRACT OF UNRIPE Carica papaya ON ELECTROLYTE PROFILE OF ALLOXAN INDUCED DIABETIC RAT1 OBINNA ... 8. THE EFFECT OF METHANOLIC EXTRACT OF UNRIPE Carica papaya ON ELECTROLYTE PROFILE OF ALLOXAN INDUCED DIABETIC RAT1 OBINNA ... 4. EFFECT OF Solanum macrocarpon AND ANTI-DIABETIC DRUG GLIBENCLIMIDE ON SOME BLOOD PARAMETERS OF ALLOXAN INDUCED DIABETIC RATS ...
Serum Biochemical Changes in Alloxan-induced Diabetic Rats and Ameliorative Effects of Moringa oleifera and Morinda lucida Leaf...
Serum Biochemical Changes in Alloxan-induced Diabetic Rats and Ameliorative Effects of Moringa oleifera and Morinda lucida Leaf ... Rats in groups 1-6 were made diabetic via a single injection of alloxan monohydrate (160 mg/kg i.p). Animals whose blood ... Abd El Latif, A., El Bialy Bel S., Mahboub, H.D., AbdEldaim, M.A. (2014). Moringaoleifera leaf extract ameliorates alloxan- ... Serum Biochemical Changes in Alloxan-induced Diabetic Rats and Ameliorative Effects of Moringa oleifera and Morinda lucida Leaf ...
Effect of Muntingia calabura L. Leaf Extract on Blood Glucose Levels and Body Weight of Alloxan-Induced Diabetic Mice |...
Effect of Muntingia calabura L. Leaf Extract on Blood Glucose Levels and Body Weight of Alloxan-Induced Diabetic Mice. Primary ... Objective: To evaluate the effect of Muntingia calabura L. leaf extract on the blood glucose level and weight of alloxan- ... Solikhah TI, Solikhah GP. Effect of Muntingia calabura L. Leaf Extract on Blood Glucose Levels and Body Weight of Alloxan- ... Effect of Muntingia calabura L. Leaf Extract on Blood Glucose Levels and Body Weight of Alloxan-Induced Diabetic Mice. * ...
Assessment of the Histopathological Changes Occurring in the Testis of the Mice Suffering from Experimental Diabetes Induced...
Keywords: Alloxan, diabetes, testis, Helichrysum plicatum DC, Tanacetum balsamita L., mouse, histopathology, TUNEL, ... on the histopathology of the testicles of the mice that had alloxan-induced type 1 diabetes or with imitated physiopathology of ... of the Histopathological Changes Occurring in the Testis of the Mice Suffering from Experimental Diabetes Induced Using Alloxan ...
Streptozocin a-anomer = 75 , = 98 HPLC, powder 18883-66-4
African Journal of Biochemistry Research - November, 2009 edition
Scientia Pharmaceutica | An Open Access Journal from MDPI
Mendel Friedman : USDA ARS
The effects of corn silk on glycaemic metabolism | Nutrition & Metabolism | Full Text
Also, the body weight of the alloxan-induced hyperglycemic mice was increased gradually. However, ascension of blood glucose ... The alloxan-damaged pancreatic β-cells of the mice were partly recovered gradually after the mice were administered with corn ... the blood glucose and the HbA1c were significantly decreased in alloxan-induced hyperglycemic mice (p < 0.05, p < 0.01, ... Although corn silk extract increased the level of hepatic glycogen in the alloxan-induced hyperglycemic mice, there was no ...
Rats18
- This study aims to examine the effects of flax and pumpkin powder seed mixture on alloxan induced diabetes in Wistar rats. (nih.gov)
- The effects of the extract on the haematological and some biochemical parameters of alloxan-induced diabetic rats were investigated. (scirp.org)
- Therefore, the present study was undertaken to provide information on the restorative effects of dichloromethane/methanol (1:1) extract of N. laevis leaves on alloxan-induced diabetic rats using biochemical indices of the liver and kidney functions as well as haematological parameters. (scirp.org)
- Alloxan-induced diabetic rats were treated with insulin (i.p.) or with Capparis decidua powder as a hypoglycaemic agent mixed with diet. (iisc.ac.in)
- A single oral dose of 250, 500 and 1000 mg/kg of the extract was evaluated for hypoglycemic activity in a glucose tolerance test in normal rats and for antihyperglycemic activity in alloxan-induced (140 mg/kg) diabetic rats. (una.ac.cr)
- 0.05) blood glucose levels in alloxan induced hyperglycemic rats at 4 and 5 h. (una.ac.cr)
- Zingebiraceae ) on serum lipid profile and on blood glucose in alloxan-induced diabetes and propylthiouracil-induced hypothyroidism in rats. (phcogres.com)
- Objective: To study the effect of 50% ethanolic extract of Terminalia arjuna bark on glucose and lipid profile in serum, kidney, liver and adipose tissue in alloxan induced diabetic rats. (i-scholar.in)
- Methods: Oral administration of the Terminalia arjuna stem bark extract daily at a dose of 250 and 500 mg/kg body weight to alloxan induced diabetic rats for a period of 30 days. (i-scholar.in)
- Results: Significant reduction in glucose and lipid profile in serum and tissues of alloxan induced diabetic rats was noticed, the extract even under high concentration (500 mg/kg body weight) showed no toxic effect in control rats. (i-scholar.in)
- Alloxan was induced into 15 male wister albino rats and 5 male wister albino rats were used for the normal control group. (grossarchive.com)
- This research project studied the effect of ethanolic leaf extract of Dialium guineense Willd (Fabaceae) on oral glucose tolerance in mice and alloxan-induced diabetic female rats. (grossarchive.com)
- This study investigated the effects of Eucalyptus globules on alloxan -induced diabetic rats. (grossarchive.com)
- Diabetes mellitus commonly known as diabetes is a group of metabolic disorder characterized by high blood sugar level over a prolonged period (WHO,2014) This research is aimed at investigating effect of solanum macrocapon and Anti-diabetic drug glibenclamide on some blood parameters of alloxan induced diabetic rats. (grossarchive.com)
- The effect of Gongronema latifolium on serum cardiac enzymes in alloxan induced diabetic rat models and normal control rats were determined using graded doses of 80% ethanol extract of G. latifolium leaf. (academicjournals.org)
- of artichoke on the changes of serum glucose, lipids and lipoproteins in ALLOXAN MONOHYDRATE -induced diabetic rats was investigated. (sid.ir)
- Screening and comparison of the antidiabetic properties of Phylanthus niruri in alloxan-induced rats. (iium.edu.my)
- Alloxan induced diabetic rats were post treated with plant extracts (150 mg/kg) and serum samples were colle. (researcherslinks.com)
Monohydrate4
- I present diabetes study was induced in albino rat models with the alloxan monohydrate. (pharmacognosyjournal.in)
- Second group (diabetic), received 120 mg/kgbw ALLOXAN MONOHYDRATE . (sid.ir)
- Fourth group (diabetic + Cynara scolymus) at first became diabetic by ALLOXAN MONOHYDRATE injection, then they received 300 mg/kgbw hydroalcoholic plant extract. (sid.ir)
- The objective of this work is to study the effect of Clerodendrum formicarum (100, 150 and 200 mg/kg body weight) on astrocytes and microglial cells in a model of diabetic neuropathic pain induced by alloxan monohydrate (150 mg/kg). (scirp.org)
Diabetes Mellitus2
- Alloxan, a diabetogenic compound, is used to induce type 1 diabetes mellitus in animals. (greenmedinfo.com)
- RW may be useful in preventing alloxan-induced type 1-diabetes mellitus. (greenmedinfo.com)
Extract4
- Assessment of the antidiabetic potential of extract and novel phytoniosomes formulation of Tradescantia pallida leaves in the alloxan-induced diabetic mouse model. (bvsalud.org)
- The leaves extract and phytoniosomes of T. pallida in doses of 15, 25 and 50 mg/kg were used to assess the oral glucose loaded, and alloxan -induced diabetic mice models. (bvsalud.org)
- To evaluate the effect of Muntingia calabura L. leaf extract on the blood glucose level and weight of alloxan-induced diabetic mice. (phcogj.com)
- M. calabura leaf extract had a significant antidiabetic effect that can normalize the weight of alloxan-induced diabetic mice. (phcogj.com)
Mice2
- The mice were injected using 150mg/kg of alloxan intraperitoneally to induce diabetes. (phcogj.com)
- In this study, we aimed to examine the effect of volatile oil extracts of Helichrysum plicatum DC (HP) and Tanacetum balsamita L. (TB) on the histopathology of the testicles of the mice that had alloxan-induced type 1 diabetes or with imitated physiopathology of type 2 diabetes. (yyu.edu.tr)
Insulin4
- Alloxan-treated HIT-T15 cells exhibited lowered viability, increased intracellular ROS levels, elevated cytosolic free Ca(2+) concentration, DNA fragmentation, decreased intracellular ATP levels and lowering of glucose-stimulated release of insulin. (greenmedinfo.com)
- RW completely prevented the generation of alloxan-induced ROS, increase of cytosolic Ca(2+) concentration, decrease of intracellular ATP level, and lowering of glucose-stimulated insulin release, and strongly blocked DNA fragmentation, partially suppressing the lowering of viability of alloxan-treated cells. (greenmedinfo.com)
- The insulin, glucose and cholesterol level and activity of lysosomal enzymes in the course of the model alloxan diabetes. (nel.edu)
- Witek B, Król T, Kołataj A, Ochwanowska E, Stanisławska I, Slewa A. The insulin, glucose and cholesterol level and activity of lysosomal enzymes in the course of the model alloxan diabetes. (nel.edu)
Effect2
- Protective mechanism of reduced water against alloxan-induced pancreatic beta-cell damage: Scavenging effect against reactive oxygen species. (greenmedinfo.com)
- Overall, administration of DME has significant ameliorative effect on alloxan-induced anaemia and other haematological alterations in diabetes and this may be of immense benefits in the management of diabetes and its associated haematological complications. (scirp.org)
Injection1
- Blood glucose level was tested before alloxan injection and 5 days after injection to confirm diabetes development. (phcogj.com)
Oral1
- Se evaluó la actividad hipoglucémica de una dosis oral única de 250, 500 y 1000 mg/kg del extracto en una prueba de tolerancia a la glucosa en ratas normales y la actividad antihiperglucémica en ratas diabéticas inducidas por aloxano (140 mg/kg). (una.ac.cr)
Experimental1
- IMSEAR at SEARO: Experimental diabetes in guineapigs by alloxan. (who.int)
Results1
- These results suggest that RW protects pancreatic beta-cells from alloxan-induced cell damage by preventing alloxan-derived ROS generation. (greenmedinfo.com)