Accelerated intimal hyperplasia and increased endogenous inhibitors for NO synthesis in rabbits with alloxan-induced hyperglycaemia. (1/243)

1. We examined whether endogenous inhibitors of NO synthesis are involved in the augmentation of intimal hyperplasia in rabbits with hyperglycaemia induced by alloxan. 2. Four weeks after the endothelial denudation of carotid artery which had been performed 12 weeks after alloxan, the intimal hyperplasia was greatly augmented with hyperglycaemia. The degree of hyperplasia was assessed using three different parameters of histopathological findings as well as changes in luminal area and intima: media ratio. 3. There were positive and significant correlations between intima:media ratio, plasma glucose, and concentrations of N(G)-monomethyl-L-arginine (L-NMMA) and N(G), N(G)-dimethyl-L-arginine (ADMA) in endothelial cells, that is, the intima:media ratio became greater as plasma glucose and endothelial L-NMMA and ADMA were increased. Furthermore, endothelial L-NMMA and ADMA were increased in proportion to the increase in plasma glucose. 4. In contrast, there were inverse and significant correlations between cyclic GMP production by carotid artery strips with endothelium and plasma glucose, between cyclic GMP production and endothelial L-NMMA and ADMA, and between the intima:media ratio and cyclic GMP production. 5. Exogenously applied L-NMMA and ADMA inhibited cyclic GMP production in a concentration-dependent manner. IC50 values were determined to be 12.1 microM for the former and 26.2 microM for the latter. The cyclic GMP production was abolished after the deliberate removal of endothelium from the artery strips. 6. These results suggest that the augmentation of intimal hyperplasia with hyperglycaemia is closely related to increased accumulation of L-NMMA and ADMA with hyperglycaemia, which would result in an accelerated reduction in NO production/release by endothelial cells.  (+info)

Alloxan in vivo does not only exert deleterious effects on pancreatic B cells. (2/243)

The aim of the experiment was to investigate the mechanism of harmful alloxan action in vivo. 75 mg/kg b.w. of this diabetogenic agent were administered to fasting rats. Two minutes later the animals were decapitated. It was observed that alloxan caused a distinct rise in blood insulin and glucose levels with a concomitant drop of free fatty acids. The amount of sulfhydryl groups in the liver of alloxan-treated rats was decreased and glutathione peroxidase activity was substantially higher. These results indicate that some changes observed in alloxan-induced diabetes can not only be the consequence of B cells damage by alloxan but may also be the result of its direct influence on other tissues. It was also observed that glucose given 20 min before alloxan injection only partially protected against the deleterious effects of alloxan.  (+info)

Intercalated duct cells in the chicken pancreatic islet with special reference to the alloxan administration. (3/243)

The intercalated duct cells were observed in the A and B islets of the chicken pancreas. These cells adhered with each other by intercellular junctional complexes at the apical side. They had many microvilli projecting into the lumen. Abluminally, they displayed extended slender cytoplasmic processes between islet endocrine cells. Administration of alloxan resulted to denser cytoplasm and a more prominent thickening of cytoplasmic processes of the intercalated duct cells, although the blood glucose levels did not show appreciable changes by the treatment. The intercalated duct epithelial cells appeared clearly as stellate cells. The lysosomes increased in size and number with passage of time after alloxan administration. The present findings may suggest that intercalated ducts are not only anatomically important as a structure passing through the islet but also play physiologically by protecting the islet endocrine cells.  (+info)

Reduced coronary NO production in conscious dogs after the development of alloxan-induced diabetes. (4/243)

The role of nitric oxide (NO) in the control of coronary blood flow (CBF) during the development of diabetes is unknown. To study this, mongrel dogs were chronically instrumented using sterile techniques for measurements of systemic hemodynamics and CBF. With heart rate controlled (150 beats/min), veratrine (1-10 micrograms/kg) caused dose-dependent increases in CBF; e.g., 5 mirograms/kg of veratrine increased CBF by 57 +/- 7% from 41 +/- 1.3 ml/min (P < 0.05). The dogs developed diabetes 4-5 wk after injection of alloxan (40-60 mg/kg iv, blood glucose levels were 384 +/- 18 mg/dl). After diabetes the same doses of veratrine caused smaller increases in CBF; i.e., 5 micrograms/kg of veratrine increased CBF by 32 +/- 2% (P < 0.05 compared with control) from 28 +/- 4 ml/min. ACh- and adenosine-induced coronary vasodilation were reduced after diabetes as well. In anesthetized dogs after diabetes, vagal stimulation caused smaller increases in CBF. ACh and bradykinin caused smaller increases in NO(-)(2) production in coronary microvessels from diabetic dogs. Furthermore, despite the fact that mRNA for endothelial cell NO synthase from the aorta was increased twofold with the use of Northern blotting, the protein for aortic endothelial constitutive NO synthase was reduced by 66% after diabetes, as determined by Western blotting. Our results indicate that the NO-dependent coronary vasodilation by the Bezold-Jarisch reflex is impaired in conscious dogs after diabetes. The mechanism responsible for the impaired endothelium-dependent coronary vasodilation is most likely the decreased release of NO from the endothelium.  (+info)

Supplementation of N-acetylcysteine inhibits NFkappaB activation and protects against alloxan-induced diabetes in CD-1 mice. (5/243)

Reactive oxygen species (ROS) are involved in the destruction of pancreatic beta cells and the development of insulin-dependent diabetes mellitus (IDDM). However, the cellular mechanism responsible for beta cell death is still unclear. We hypothesize that activation of NFkappaB by ROS is the key cellular signal in initiating a cascade of events leading to beta cell death. Thus, enhancement of pancreatic GSH, a known antioxidant and key regulator of NF-kappaB, should protect against IDDM. Weanling CD1 mice (n=5) were injected with alloxan (50 mg/kg i.v.) to induce IDDM. Using EPR spin trapping techniques, we demonstrated that alloxan generated ROS in the pancreas 15 min after administration. Activation of NFkappaB in pancreatic nuclear extracts was observed 30 min after alloxan injection, as assessed by an electrophoretic mobility shift assay. Fasting blood glucose levels were monitored for 14 days. Supplementation with N-acetylcysteine (NAC, 500 mg/kg), a GSH precursor, inhibited alloxan-induced NFkappaB activation and reduced hyperglycemia. Thus, NFkappaB activation by ROS may initiate a sequence of events leading to IDDM. Inhibition of NF-kappaB activation by NAC attenuated the severity of IDDM. This research will contribute to the understanding of the etiology of IDDM and may lead to the development of better strategies for disease prevention.  (+info)

Lipolysis induced by alloxan in rat adipocytes is not inhibited by insulin. (6/243)

Isolated rat adipocytes were incubated with adrenaline, adrenaline plus insulin, alloxan or alloxan plus insulin. Glycerol release was taken as a measure of lipolysis. It was observed that alloxan in the concentration of 3, 10 and 20 mmol/l intensifies lipolysis in adipocytes in the absence of adrenaline. Insulin (10(-6) mol/l) treatment of cells did not inhibit lipolysis caused by this compound, but significantly restricted lipolysis induced by adrenaline (10(-6) mol/l). It was also shown that alloxan in the concentration of 3 and 10 mmol/l intensified lipolysis stimulated by adrenaline (10(-6) mol/l). Addition of 20 mmol/l of alloxan strongly inhibited glycerol release in the presence of adrenaline. The results presented here clearly indicate that the action of alloxan concerns cells of the white adipose tissue.  (+info)

Resistance of ALR/Lt islets to free radical-mediated diabetogenic stress is inherited as a dominant trait. (7/243)

ALS/Lt and ALR/Lt are inbred mouse strains selected for susceptibility and resistance to alloxan (AL)-induced diabetes. Within 24-h after AL administration in vivo, ALS/Lt islets were distinguished from ALR/Lt islets by more extensive necrotic changes. Within 7 days post-AL, ALS/Lt mice exhibited hyperglycemia and hypoinsulinemia, whereas ALR/Lt mice maintained normal plasma insulin and glucose levels. We have recently shown that resistance in ALR/Lt correlated with constitutively elevated systemic (and pancreatic) free radical defense status. In the present report, we examined whether ability to detoxify free radical stress extended to the level of ALR/Lt pancreatic islets. Cultured ALS/Lt islets exposed for 5 min to increasing (0-3 mmol/l) AL concentrations in vitro exhibited an 80% decline in numbers of intact islets after a subsequent 6-day culture period, as well as a 75% reduction in islet insulin content and a 94% decrease in glucose-stimulated insulin secretory capacity. In contrast, ALR/Lt islets remained viable and retained glucose-stimulated insulin secretory capacity as well as normal insulin content. This ALR/Lt islet resistance extended to hydrogen peroxide, a free radical generator whose entry into beta-cells is not dependent on glucose transporters. The elevated antioxidant defenses previously found in ALR/Lt pancreas were extended to isolated islets, which exhibited significantly higher glutathione and Cu-Zn superoxide dismutase 1 levels compared with ALS/Lt islets. A dominant genetic trait from ALR/Lt controlling this unusual AL resistance was indicated by the finding that reciprocal F1 mice of both sexes were resistant to AL administration in vivo. A backcross to ALS/Lt showed 1:1 segregation for susceptibility/resistance, indicative of a single gene controlling the phenotype. In conclusion, the ALR/Lt mouse may provide important insight into genetic mechanisms capable of rendering islets strongly resistant to free radical-mediated damage.  (+info)

Protective mechanism of glucose against alloxan-induced beta-cell damage: pivotal role of ATP. (8/243)

Glucose prevents the development of diabetes induced by alloxan. In the present study, the protective mechanism of glucose against alloxan-induced beta-cell damage was investigated using HIT-T 15 cell, a Syrian hamster transformed beta-cell line. Alloxan caused beta-cell damages with DNA fragmentation, inhibition of glucose-stimulated insulin release, and decrease of cellular ATP level, but all of these beta-cell damages by alloxan were prevented by the presence of 20 mM glucose. Oligomycin, a specific inhibitor of ATP synthase, completely abolished the protective effects of glucose against alloxan-induced cell damage. Furthermore, treatment of nuclei isolated from HIT-T15 cells with ATP significantly prevented the DNA fragmentation induced by Ca2+. The results indicate that ATP produced during glucose metabolism plays a pivotal role in the protection of glucose against alloxan-induced beta-cell damage.  (+info)

*Alloxan

... , sometimes referred to as alloxan hydrate, refers to the organic compound with the formula OC(N(H)CO)2C(OH)2. It is ... The name "Alloxan" emerged from an amalgamation of the words "allantoin" and "Oxalsäure" (oxalic acid). The alloxan model of ... Studies suggests that alloxan does not cause diabetes in humans. Others found a significant difference in alloxan plasma levels ... A dimeric derivative alloxantin can be prepared by partial reduction of alloxan with hydrogen sulfide. Alloxan is a toxic ...

*Stevia rebaudiana

Bertoni) on alloxan-induced diabetic rats". J Pharm Bioallied Sci. 3 (2): 242-8. doi:10.4103/0975-7406.80779. PMC 3103919 . ...

*Momordica cymbalaria

Fruit powder in alloxan-diabetic rats". Journal of Ethnopharmacology. 67 (1): 103-109. doi:10.1016/S0378-8741(99)00004-5. PMID ...

*Streptozotocin

Szkudelski T (2001). "The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas". Physiol Res. 50 (6): ... Streptozotocin is now marketed by the generic drug company Sicor (Teva). Alloxan Brentjens R, Saltz L (2001). "Islet cell ... "Comparison of metabolic abnormalities in diabetes mellitus induced by streptozotocin or by alloxan". Lancet. 1 (7544): 670-1. ...

*Solanum anguivi

Fruit in alloxan-induced diabetic Rats". South African Journal of Botany. 88: 56-61. doi:10.1016/j.sajb.2013.04.010. ... Vivo antioxidant activities in alloxan-induced oxidative stress". Asian Journal of Pharmaceutical and Clinical Research. 6: 249 ...

*Pleurotus pulmonarius

with Glyburide in Alloxan Induced Diabetic Mice". Evidence-Based Complementary and Alternative Medicine. 5 (2): 159-164. doi: ... and reduced the mortality of alloxan induced diabetic mice by approximately 50%. It showed a synergistic effect with the ...

*Maud Menten

Menten, ML.; Janouch, M. (1946). "Changes in alkaline phosphatase of kidney following renal damage with alloxan". Proceedings ...

*Taurine

... antioxidative and nephroprotective effects of taurine in alloxan diabetic rabbits". Biochimie. 91 (2): 261-270. doi:10.1016/j. ...

*Artemisia pallens

On blood glucose levels in normal and alloxan-induced diabetic rats". Journal of Ethnopharmacology. 50 (1): 13-7. doi:10.1016/ ... fed hyperglycemic and alloxan-treated rabbits and rats. Davana oil is used in making perfumes of sweet and fruity fragrances. ...

*Helicteres isora

Venkatesh, S., Reddy, G. D., & Reddy, B. M. (2003). Antihyperglycemic activity of Helicteres isora roots in alloxan-induced ...

*Laboratory Syrian hamster

Streptozotocin or alloxan may be administered to induce chronic diabetes in hamsters. Atherosclerosis may be studied with ...

*Scoparia dulcis

"Antidiabetic and antioxidant effect of Scoparia dulcis in alloxan induced albino mice" (PDF). International Journal of ...

*Strecker degradation

Strecker, A (1862). "Notiz über eine eigenthümliche Oxydation durch Alloxan" [Notice of a curious oxidation by alloxan]. ... The original observation by Strecker involved the use of alloxan as the oxidant in the first step, followed by hydrolysis: The ...

*Mladen Vranic

"Importance of glucagon in the control of futile cycling as studied in alloxan-diabetic dogs". Diabetologia. 30: 175-182. doi: ... reduction in pancreatic glucagon with normalization of somatostatin and decrease in insulin in normoglycemic alloxan-diabetic ...

*Ocimum gratissimum

Anti‑hyperlipidemic effect of aqueous leaf extract of Ocimum gratissimum in alloxan induced diabetic rats. Int J Med Med Sci ... Aqueous leaf extract of Ocimum gratissimum improves hematological parameters in alloxan-induced diabetic rats via its ... Effect of aqueous leave extract of Ocimum gratissimum on alloxan induced diabetic rat. PHCOG MAG Vol 1, Issue 2, 62-64 Ayinla ...

*Murexide

It may also be prepared by digesting alloxan with alcoholic ammonia at about 78 °C; the purple solid so formed is easily ...

*Vitamin E

Later, in 1948, while conducting experiments on alloxan effects on rats, Gyorge and Rose noted rats receiving tocopherol ... "Effect of dietary factors on early mortality and hemoglobinuria in rats following administration of alloxan". Science. 108 ( ...

*Glucose-6-phosphate translocase

Omotade, OI (2009). "Glucose-6-phosphatase activity in selected rabbit tissues of normal and alloxan induced diabetic rabbit". ...

*Pomiferin

Bartosíková, L (2007). "Examination of the antioxidative and antidiabetic effect of pomiferin in alloxan-induced diabetes ...

*Pyrimidine

Although pyrimidine derivatives such as uric acid and alloxan were known in the early 19th century, a laboratory synthesis of a ... Grimaux, E. (1879). "Synthèse des dérivés uriques de la série de l'alloxane" [Synthesis of urea derivatives of the alloxan ... and alloxan. It is also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. ...

*Norbu (sweetener)

... blood lipid and antioxidation of hyperglycemic mice induced by Alloxan,"". Chinese Pharmacological Bulletin. pp. 237-240. ...

*Fenton's reagent

Brömme HJ, Mörke W, Peschke E (November 2002). "Transformation of barbituric acid into alloxan by hydroxyl radicals: ...

*Beta cell

Diabetes mellitus can be experimentally induced for research purposes by streptozotocin or alloxan, which are specifically ...

*Friedrich Wilhelm Hermann Delffs

... molybdate of ammonia and alloxan. In 1843, with mineralogist Johann Reinhard Blum, he proposed the name "leonhardite" for ...

*Artemisia herba-alba

An aqueous extract of aerial parts of the plant has shown a hypoglycemic effect in alloxan-induced diabetic rabbits and mice. ...
Cytochrome c was reduced when superoxide was generated from xanthine oxidase in the presence of alloxan, and by the reaction of alloxan and with reduced glutathione. In each case, most of the reduction was inhibited by superoxide dismutase, but considerably more enzyme was required than with superoxide alone. This indicates that the superoxide dismutase-inhibitible cytochrome c reduction was mainly due to a direct reaction with the alloxan radical, and implies that other reactions that are inhibited by superoxide dismutase could be due to either alloxan radicals or superoxide.. ...
Diabetes mellitus is gradually becoming a global health burden leading to an increase in the search for herbal hypoglycemic agents as alternatives to synthetic ones. Asystasia gangetica is one of the herbs used in folklore system of medicine for managing hypoglycaemia associated with diabetes. Materials and Methods: The influence of the juice of A. gangetica leaf on alloxan-induced diabetic rats was assessed by treating diabetic rats with 25%, 50% and 75% fresh juice and glibenclamide for 5 weeks. Afterwards, the plasma concentrations of glucose, triacylglycerols, total cholesterol, high-density lipoprotein (HDL) cholesterol, thiobarbituric acid reactive substances and bicarbonate were assayed spectrophotometrically. Results: Treatment of the diabetic rats with the juice significantly (P , 0.05) reduced the elevated plasma levels of glucose to a level not significantly (P , 0.05) different from that of glibenclamide. The juice also significantly (P , 0.05) reduced the plasma lipid peroxidation ...
Effects of Diabetes Mellitus Induced by Alloxan on the Pharmacokinetics of Metformin in Rats: Restoration of Pharmacokinetic Parameters to the Control State by Insulin Treatment
The report generally describes alloxan, examines its uses, production methods, patents. Alloxan market situation is overviewed; alloxan manufacturers
BioAssay record AID 296187 submitted by ChEMBL: Reduction in plasma triglyceride level in alloxan-induced diabetic mouse, po after 15 days.
Abstract: Activation of lipid peroxidation was observed in development of alloxan diabetes in young (5-6 months old) and old rats (24-26 months old). Slight inhibition of lipid peroxidation was detected within 10 days of the development of diabetes. The compensatory-adaptation reactions, particularly activation of Zn, Cu-superoxide dismutase, were apparently responsible for the inhibition of lipid peroxidation observed ...
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Semantic Scholar extracted view of [Postoperative changes in the lipid content of the liver, placenta and embryo of normal, alloxan diabetic and insulin-treated rats]. by W Haude et al.
Abstract: Fatty acid composition and lipid peroxidation in rat brain microsomes were studied under conditions of alloxan diabetes. The data obtained indicate significant differences in the content of unsaturated fatty acids and also a slight activation of lipid peroxidation in the pathological state studied ...
Archives issue of International Journal of Pharma and Bio Sciences which aims to cover the latest outstanding developments in the field of pharmaceutical and biological sciences
Free Online Library: The use of alloxan and streptozotocin in experimental diabetes models by Turkish Journal of Endocrinology and Metabolism; Health, general Diabetes Diabetes mellitus Pyrimidines Streptozocin
Abstract Alloxan and streptozotocin are widely used to induce experimental diabetes in animals. The mechanism of their action in B cells of the pancreas has been intensively invest..
Alloxan monohydrate,98.5 % min,white crystalline powder/ACM2241113 can be provided in Alfa Chemistry. We are dedicated to provide our customers the best products and services.
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Administration of propolis to diabetic mice resulted in a significant increase of body weight, haematological and immunological parameters of blood as well as 100% survival of diabetic mice. Alloxan-injected mice showed a marked increase in oxidative stress in liver and kidney homogenate, as determined by lipid peroxidation. Histopathological observation of the liver sections of alloxan-induced diabetic mice showed several lesions including cellular vacuolization, cytoplasmic eosinophilia and lymphocyte infiltrations, but with individual variability.Treatment of diabetic mice with propolis extracts results in decreased number of vacuolized cells and degree of vacuolization; propolis treatment improve the impairment of fatty acid metabolism in diabetes. Renal histology showed corpuscular, tubular and interstitial changes in alloxan-induced diabetic mice. Test components did not improve renal histopathology in diabetic mice ...
It is known that the development of diabetic complications in human pregnancy is directly related to the severity and the duration of this pathology. In this study, we developed a model of long-term type 1 diabetes to investigate its effects on the cytoarchitecture, extracellular matrix and cell proliferation during the first adaptation phase of the myometrium for pregnancy. A single dose of alloxan was used to induce diabetes in mice prior to pregnancy. To identify the temporal effects of diabetes the mice were divided into two groups: Group D1 (females that became pregnant 90-100 days after alloxan); Group D2 (females that became pregnant 100-110 days after alloxan). Uterine samples were collected after 168 h of pregnancy and processed for light and electron microscopy. In both groups the histomorphometric evaluation showed that diabetes promoted narrowing of the myometrial muscle layers which was correlated with decreased cell proliferation demonstrated by PCNA immunodetection. In D1, diabetes
The starchy flour is then given a chlorine gas bath in order to bleach it and make it white. Chlorine gas is a flour bleaching and oxidising agent that is a powerful irritant that is dangerous to inhale. The chlorine gas reacts with the flour to oxidise it and make it white. But it also converts a dough additive called xanthine into a toxic substance called alloxan. The latter is a toxin which destroys pancreatic islet cells resulting in diabetes. Alloxan has been used in lab tests to deliberately induce diabetes in rats. Trace elements of alloxan are left in the end product. ...
The reticulocytes and the ageing red blood cells (RBCs) namely young (Y), middle-aged (M) and old RBCs (O) of female Wistar rats from different groups such as control animals (C), controls treated with vanadate (C + V), alloxan-induced diabetic (D), diabetic-treated with insulin (D + I) and vanadate (D + V), were fractionated on a percoll/BSA gradient. The following enzymes were measured-hexokinase (HK), glutathione peroxidase (GSH-Px), glutathione reductase (GSSG-R), glutathione-s-transferase (GST), alanine aminotransferase ΜlaAT), aspartate aminotransferase ΜsAT) and arginase in the hemolysates of all the RBCs fractions. Decreases in the activity of HK and AsAT by about 70%, arginase and GSH-Px by 30% in old RBCs were observed in comparison to reticulocytes of control animals. Increases in the activity of GSSG-R by 86%, AlaAT by more than 400% and GST by 70% were observed in old RBCs in comparison to reticulocytes of control animals.. Alloxan diabetic animals showed a further decrease in the ...
The relationship between concentrations of blood glucose and nonenzymatically glucosylated serum proteins was studied in rats with alloxan-induced diabetes of varying severity. Fasting serum glucose correlated strongly with both glucosylated albumin (r = 0.91, P less than 0.001) and glucosylated serum protein (r = 0.93, P less than 0.001). The relative rates of response of serum protein and hemoglobin glycosylation to changes in blood glucose were also compared. Following withdrawal of insulin from diabetic rats, the half-times to reach new steady state levels of blood glucose, glucosylated serum proteins, and glycohemoglobins were about 2, 3, and 8 days, respectively. Similarly, on reinstitution of insulin therapy, the half-times for these same indices to return to baseline values were 2, 3.5, and 15 days, respectively. Changes in glucosylated albumin were more sensitive than glycohemoglobins to changes in serum glucose, consistent with the observation that albumin was glucosylated at about 10 times
Materials and Methods: Alloxan diabetic rats treated orally with ethanolic extract of ISWF (0-400mg/kg) for 28 days. To evaluate its anti-diabetic activity, the animals fasting blood glucose were determined on the first, 14th and 29th days. Moreover, oral glucose tolerance test (OGTT) was performed in diabetic rats at the last day of the study. After 24h of last administration, the blood samples were collected, and the Plasma lipids and liver enzymes levels were measured in fasting overnight rats ...
Background & Objectives: Alloxan & streptozotocin are used for inducing diabetic models. Their combination has been used to reduce the individual chemical dosage and minimize the side effects. Present investigation was aimed at studying pre-diabetic clinical changes induced by low doses of Alloxan-STZ cocktail in rabbits. Methods: New Zealand White rabbits, 1-1.5 kg body weight, were administered alloxan (@50 mg/kg b.w.) and STZ (@ 35mg/kg b.w.) cocktail, as single intravenous dose. Blood glucose levels were monitored (0 h, 20 min, 1 h, and then hourly up to 9 h) and clinical signs noted. Rabbits surviving up to 9 hours were given glucose therapy. Results: The cocktail caused immediate transient hypoglycaemia, followed by hyperglycaemia, and then progressively severe hypoglycaemia. Hypoglycaemia caused characteristic behavioural alterations from lethargy, through aesthesia, muscular weakness to recumbency. Severely affected rabbits revealed intermittent convulsions and died in coma. Conclusion: Low
2. Chlorine dioxide, one of the chemicals used to bleach flour, combines with residual protein in most of these foods to form alloxan. In the lab, researchers use alloxan to induce diabetes in rats. Enriched or white anything, is dangerous, period ...
Madras High Court has directed Food Safety and Standard Authority to look into the alleged mixing of a harmful chemical in refined flour and take action if
The murine model for disseminated infection by C. albicans has been well characterized [28-30]. When fungal cells are intravenously inoculated by lateral tail vein, the fungus spreads rapidly, mimicking the infection that occurs when fungal cells enter the blood stream through the gastrointestinal tract, or an intravenous catheter. In our infected-mice, as previously described in non-progressive Candida hematogenous infection, the infection is controlled in the majority of the tissues, including the liver, spleen, heart and lungs but advances in the kidney and brain [30, 31]. Here, we have amplified these findings using HH mice induced by alloxan. The choice of alloxan-induced HH mice has two rationales. The first one is due to DM represent an important import underlying disease in episodes of candidemia (13-21%) [1-3], and the second is because this condition interferes in the animal defense mechanisms, therefore making possible the study of the immunological alterations involved in the ...
According to our previous studies, propolis of Nigerian origin showed some evidence of hypoglycemic and hypolipidemic activities in addition to its ability to ameliorate oxidative-stress-induced organ dysfunction. This study was carried out to determine whether an ethanolic extract of Nigerian propolis (EENP) improves glycated hemoglobin A1c (HbA1c), fasting plasma glucose, very low-density lipoprotein (VLDL), and high-density lipoprotein (HDL) concentrations in rats that have alloxan diabetes ...
In the experiment, we used a technique for administering special material (alloxan) and causing diabetes in healthy mice and, by analyzing and comparing the blood glucose level of mice that been irradiated by a low dose of radiation and mice that were not irradiated, we examined whether low dose irradiation controlled the incidence of diabetes ...
Alhagi graecorum is used in the folk medicine and might be beneficial in certain medical conditions. Experiment was thus designed to evaluate the poss..
Looking for online definition of alloxan diabetes in the Medical Dictionary? alloxan diabetes explanation free. What is alloxan diabetes? Meaning of alloxan diabetes medical term. What does alloxan diabetes mean?
Abstract: Background and Objective: Nauclea latifolia root-bark extracts are used traditionally to treat various diseases. The study investigated phytochemical compositions and effects of methanol extract of Nauclea latifolia root-bark on liver and kidney function parameters of alloxan induced diabetic male wistar rats to understand possible effect it could have on those who use the extract to manage diabetes. Materials and Methods: The acute toxicity study was carried out using 18 male mice while 30 male Wistar albino rats were used to study the effects of the extract on the liver and kidney function parameters using standard analytical methods. The rats were divided into six groups of five rats each with group 1 as normal control, group 2 as the negative that was alloxan induced but not treated, group 3 rats were alloxan induced but treated with 2.5 mg kg 1 body weight glibenclamide . Group 4-6 rats were alloxan induced but treated with 100, 200 and 400 mg kg 1 body weight of the methanol ...
Effect of ficus relegiosa on blood glucose and total lipid levels of normal and alloxan diabetic rabbits. - Noreen Wadood, Abdul Wadood, Mohammed Nisar
ABSTRACT. Currently available drugs for diabetes mellitus pose considerable side effects. This necessitates the development of new products, particularly herbal preparations which are known to have lesser side effects. Several herbal products are used to treat diabetes; but their hypoglycemic effects are complex and few anti-diabetic plants have received proper scientific validation. The present study was undertaken to validate the use of the leaves of Nyctanthes arbor-tristis plant as anti-diabetic agent. This study was conducted on thirty healthy albino rabbits of either sex; the effect of the Nyctanthes arbor-tristis leaf extract (NALE) at doses 200mg/kg body weight and 400mg/kg body weight was evaluated for a period of 14 days on alloxan induced diabetic rabbits. The hypoglycemic effect of the leaf extract was compared with the standard Glibenclamide at dose 2.5mg/kg body weight. Results revealed that the hypoglycemic effect of the Nyctanthes arbor-tristis leaf extract at 200mg/kg body ...
Diabetes is one of the most common diseases in all societies including Iran. One of its important complications is the neuropathic pain, which can be relieved by opioid drugs such as morphine. Opioid therapy is restricted due to development of tolerance and physical or mental dependence. In this study, the effect of diabetes on morphine analgesia and development of morphine tolerance and dependence was investigated. Experimental diabetes was induced by alloxan (120 mg/kg, s.c.) in rats. Morphine sulfate (7 mg/kg, i.p.) application for 5 days developed tolerance in animals. On 5th day, 30 min after the injection of morphine, the acute and chronic pain was evaluated in diabetic and non-diabetic animals using hot plate and formalin test. In addition, withdrawal signs (jumping, chewing, urine and feces) were recorded for ten minutes using naloxone (2 mg/kg, s.c.). The results showed that the anti-nociceptive effect of morphine for acute pain markedly reduced, but slightly enhanced for chronic pain model.
Background/Aim. The mechanism of impaired bone healing in diabetes mellitus includes different tissue and cellular level activities due to micro- and macrovascular changes. As a chronic metabolic disease with vascular complications, diabetes affects a process of bone regeneration as well. The therapeutic approach in bone regeneration is based on the use of osteoinductive autogenous grafts as well as osteoconductive synthetic material, like a β-tricalcium phosphate. The aim of the study was to determine the quality and quantity of new bone formation after the use of autogenous bone and β-tricalcium phosphate in the model of calvarial critical-sized defect in rabbits with induced diabetes mellitus type I. Methods. The study included eight 4-month-old Chincilla rabbits with alloxan-induced diabetes mellitus type I. In all animals, there were surgically created two calvarial bilateral defects (diameter 12 mm), which were grafted with autogenous bone and β-tricalcium phosphate (n = 4) or served as ...
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Diabetes has become a serious health problem and a major risk factor associated with troublesome health complications, such as metabolism disorders and liver-kidney dysfunctions. The inadequacies associated with conventional medicines have led to a determined search for alternative natural therapeutic agents. The present study aimed to investigate and compare the hypoglycemic and antilipidemic effects of kombucha and black tea, two natural drinks commonly consumed around the world, in surviving diabetic rats. Alloxan diabetic rats were orally supplied with kombucha and black tea at a dose of 5 mL/kg body weight per day for 30 days, fasted overnight, and sacrificed on the 31st day of the experiment. Their bloods were collected and submitted to various biochemical measurements, including blood glucose, cholesterol, triglcerides, urea, creatinine, transaminases, transpeptidase, lipase, and amylase activities. Their pancreases were isolated and processed to measure lipase and α-amylase activities and to
Using calcium imaging as a marker of neuronal excitability, we detected glucose-excited, glucose-inhibited, and nonresponsive neurons in primary hypothalamic cell cultures, in proportions similar to those described previously (1,23). Thus, ∼30% of neurons were excited by raising the glucose concentration from 3 to 15 mmol/l, ∼6% were inhibited, and the remainder were nonresponsive over the same concentration range. The mechanism of glucose sensing in the glucose-excited neurons could not be attributed solely to KATP channel closure because tolbutamide only increased intracellular Ca2+ in ∼10% of glucose-excited neurons in the presence of 3 mmol/l glucose. Furthermore, the nonmetabolizable sugars αMDG and 3-O-MDG mimicked the action of glucose in glucose-excited neurons, indicating that metabolic generation of ATP is not a prerequisite for the sensing of glucose analogs. The sensitivity of the glucose-sensing machinery to αMDG, its dependence on extracellular Na+, and its inhibition by ...
The present study was aimed to evaluate the anti diabetic activity of polyherbal formulation containing some bitter plant constituents like neem, methi, karela fruit, amla , jamun seeds, kavat fruit in
The administration of diabetogenic doses of alloxan prior to or after the intraperitoneal implantation of the Novikoff hepatoma or of the Walker 256 carcinoma in the female Wistar rat resulted in a reduction in the size and incidence of tumors, the rate of growth bearing an inverse relationship to the severity of the diabetes.. The effect of alloxan-diabetes on the growth of subcutaneous transplants of these tumors was, in general, less pronounced, with no effect on tumor incidence.. Conversely, tumors implanted intraperitoneally before or after the administration of alloxan exerted a reciprocal effect either in mitigating its diabetogenic action or in ameliorating the diabetes. Histological study suggested a protective or stimulatory effect of these intraperitoneal tumor transplants on the beta-cells of the pancreatic islets.. ...
Mushrooms are a low calorie food with very little fat and are highly suitable for obese persons. The objective of the present investigation was to study the interaction of aqueous extract of P. pulmonarius (called PP-aqu) with acarbose on serum glucose levels, and on the oral glucose tolerance test (OGTT) in alloxan induced diabetic mice. PP-aqu (500 mg/kg), acarbose (50 mg/kg) and their combination were administered orally in alloxan (70 mg/kg i.v.) induced diabetic mice. In the acute study, the serum glucose level was estimated at 0, 2, 4, 6 and 24 h after drug administration. The subacute study involved repeated administration of the drugs for 28 days, a serum glucose level estimation at 7, 14, 21 and 28 days and recording of the body weights of the mice. In the OGTT, D-glucose (2.5 g/kg) was administered in diabetic mice half an hour after pre-treatment with PP-aqu (500 mg/kg), acarbose (50 mg/kg) and their combination. Serum glucose levels were estimated 30 min prior to glucose ...
To determine whether treatment with ginseng oligopeptides (GOPs) could modulate hyperglycemia related to type 2 diabetes mellitus (T2DM) in rats induced by high-fat diet and low doses of alloxan, type 2 diabetes was induced in male Sprague-Dawley (SD) rats by injecting them once with 105 mg/kg alloxan and feeding them high-carbohydrate/high-fat diet with or without GOP administration (0.125, 0.5, and 2.0 g/kg Body Weight) for 7, 24, and 52 weeks. Oral glucose test tolerance (OGTT), plasma glucose, serum insulin, level of antioxidant, and beta cell function were measured. Morphological observation and immunohistochemistry study of insulin of islets was performed by light microscopy. The insulin level and the expression of NF-κB and Bcl-2 family in pancreatic islets were also detected by Western blot analysis. In addition, survival time and survival rate were observed. After the treatment, the abnormal OGTT were partially reversed by GOPs treatment in diabetic rats. The efficacy of GOPs was manifested in
Organic hyperinsulinism has been recognized with increasing frequency in the last few years. It is most commonly due to adenomata of the islands of Langerhans. More and more case reports appear of successful surgical removal of these tumors with consequent alleviation of symptoms. At times there seems to be a general hypersecretion of insulin by the islet cells without discernible tumor in which resection of varying amounts of pancreatic tissue has been found effective. Carcinoma of islet cells occurs much less frequently. In these cases the tumor is often slow to grow and slow to metastasize. In a few instances ...
Al*loxan (#), n. [Allantoin + oxalic, as containing the elements of allantion and oxalic acid.] Chemistry|Chem. An oxidation produ...
Free radicals contribute to Type 1 diabetes (T1D) autoimmune responses. We recently demonstrated that superoxide-deficient CD4 T cells exhibited increased effector responses and diabetogenicity, but the redox-dependent mechanism(s) mediating T cell activation were unclear. We hypothesized that during T1D progression, CD4 T cells with a reduced cell surface state would exhibit a concomitant increase in pro-inflammatory cytokine and chemokine responses. To test this, alexa fluor 647-conjugated maleimide (ALM)-labeling of cell surface reduced thiols on diabetogenic mouse and human CD4 T cells was performed. We observed an increase in ALM percentage and gMFI from peripheral Non-obese diabetic (NOD) mouse CD4 T cells during progression to overt diabetes. Cognate autoantigen stimulation elicited a 2- and 20-fold increase in CD4 ALM T cell percentage and gMFI, respectively. In addition to serving as a T cell activation marker, ALM gMFI of reduced CD4 T cell surface thiols was enhanced (1.2-fold) with ...
The association of L-type Ca(2+) channels to the secretory granules and its functional significance to secretion was investigated in mouse pancreatic B cells. Nonstationary fluctuation analysis showed that the B cell is equipped with |500 alpha1(C) L-type Ca(2+) channels, corresponding to a Ca(2+) channel density of 0.9 channels per microm(2). Analysis of the kinetics of exocytosis during voltage-clamp depolarizations revealed an early component that reached a peak rate of 1.1 pFs(-1) (approximately 650 granules/s) 25 ms after onset of the pulse and is completed within approximately 100 ms. This component represents a subset of approximately 60 granules situated in the immediate vicinity of the L-type Ca(2+) channels, corresponding to approximately 10% of the readily releasable pool of granules. Experiments involving photorelease of caged Ca(2+) revealed that the rate of exocytosis was half-maximal at a cytoplasmic Ca(2+) concentration of 17 microM, and concentrations |25 microM are required to attain
AJ Krentz, PM Clark, CN Hales, AC Williams, M Nattrass; Pancreatic B Cell Function in Motor Neurone Disease. Clin Sci (Lond) 1 July 1992; 83 (s27): 5P. doi: https://doi.org/10.1042/cs083005P. Download citation file:. ...
TABLE-US-00003 TABLE 2 Pharmacokinetic parameters of insulin after IV, SC and IN administration to diabetic rabbits IV* SC IN IV* SC IN PK parameter 0.5 IU/kg 0.5 IU/kg 1 IU/kg 0.5 IU/kg 0.5 IU/kg 1 IU/kg Diabetic Rabbit #1 Diabetic Rabbit #2 Cmax (mIU/L) 253.7 148.4 106.5 183.1 71.6 167.3 tmax (min) 2 15 15 5 30 15 ?z (min-1) .0113 0.0263 0.0189 0.03 0.0047 0.0026 Elimination t1/2 61.1 26.3 36.7 23.1 149.0 271.1 (min) AUC0-∞ 6638.6 12192.7 5473.1 6145.1 16772.0 8675.1 (mIU min L-1) AUC0-∞/dose 13277.2 24385.5 5473.1 12290.2 33544.1 8675.1 (mIU min L-1 D-1) FRa (%) 100 100 22.4 100 100 25.9 FAb (%) 100 100 41.2 100 100 70.6 Diabetic Rabbit #3 Diabetic Rabbit #4 Cmax (mIU/L) 268.3 121.5 79.5 267.2 72.5 89.8 tmax (min) 15 15 15 5 45 15 ?z (min-1) 0.0097 0.0164 0.0235 0.0148 0.0119 0.0218 Elimination t1/2 71.7 42.3 29.4 46.8 58.4 31.9 (min) AUC0-∞ 6628.2 12798.8 3644.5 5816.2 9130.1 3845.4 (mIU min L-1) AUC0-∞/dose 13256.4 25597.7 3644.5 11632.4 18260.2 3845.4 (mIU min L-1 D-1) FRa (%) 100 ...
Compartmentalization of PDGF on extracellular binding sites dependent on exon-6-encoded sequences. Inclusion of methionine-S35 into liver slices of rats with alloxan diabetes in a medium containing glucose generic cialis or fructose Hence, fluopyram has a harmful effect on overall soil microbial activity, and tadalafil 20 mg rezeptfrei bestellen changed soil microbial community structure and function. Six males with type 2 diabetes mellitus and eight healthy controls were included.. Long sleep duration: a nonconventional indicator of arterial stiffness in Japanese at high risk of cardiovascular disease: side effects of cialis the J-HOP study. How does the number of susceptible cells influence the growth potential of the virus?. The presence of an osseous spur on the dorsoproximal aspect of MtIII in the absence of other radiological abnormalities may be an incidental finding. AfsR recruits tadalafil 5mg RNA polymerase to the afsS promoter: a model for transcriptional activation by SARPs. The ...
DI-fusion, le Dépôt institutionnel numérique de lULB, est loutil de référencementde la production scientifique de lULB.Linterface de recherche DI-fusion permet de consulter les publications des chercheurs de lULB et les thèses qui y ont été défendues.
Rat pancreatic islets have been studied following successive daily administration of dehydroascrobic acid (DHA) and during the recovery phase following 3 daily injections. One injection of DHA produces degranulation of B cells seen in the light microscope as a loss of aldehyde fuchsin positivity. In the electron microscope the B cells appear to have secretory granules accumulated subjacent to the plasma membranes. Following 2 and 3 daily injections, B cells evidence alterations in the organization of the granular endoplasmic reticulum and mitochondria, and secretory granules are scant but when present are subjacent to the plasma membrane. After 5 to 7 days recovery few secretory granules remain in B cell cytoplasm, but the cells have prominent granular ER and a Golgi apparatus with numerous prosecretory granules. The primary effect of DHA is an exaggerated secretory response of B cells, which is intensified with subsequent injections. Necrosis of B cells as produced by alloxan is not ...
Maida is made from wheat flour after removing the fiber rich bran. Then it is bleached with the chemical alloxan to make it white and fine. This chemical is toxic to Pancreas in our body. Pancreas is responsible for regulation of glucose and sugar in our body and blood. Pancreas is producing insulin in our body. Actually Insulin is responsible for the control of blood sugar. Once Pancreas is damaged, one will become diabetic. Pancreas can be damaged in many ways. Our genes and heredity also have a role in making Pancreas susceptible to injury by noxious agents. Maida or white wheat flour is used in many food stuffs world wide. The big corporate lobby world wide has succeeded in hiding the harmful effect of Maida and disseminating the information. The food industry was able to prevent any research to rule out the causation of DIABETES by Maida. The incidence of diabetes mellitus is increasing worldwide and India and Kerala is going to get the number one place in this regard. May be our food ...
In vivo antidiabetic efficacy of red algae Portieria hornemannii and Spyridia fusiformis methanol extract on alloxan stimulated hyperglycemic activity in Wistar albino rats ...
Advanced Glycation End Products, Alloxan, Antigen, Apoptosis, Behavior, Cell, Cell Number, Cell Numbers, Cells, Family, Fluorescence, Fructosamine, Histamine, Histamine Release, Injection, Intravenous Injection, Mast Cell, Mast Cells, Plasma, Pleural Cavity
Affiliation:Gifu University School of Medicine,Second Department of Internal Medicine,Assistant Professor of Medicine,医学部・附属病院,講師, Research Field:循環器内科学, Keywords:対側肺傷害,アラキドン酸代謝産物,Intravenous injection,Intratracheal instillation,二重指示薬希釈法,Alloxan-induced lung injury,アロキサン肺水腫,血管外肺水分量,成人呼吸窮迫症候群,Antiprotease, # of Research Projects:1, # of Research Products:0
Polysaccharide isolated from Hovenia dulcis Thunb.(HDP) was tested on mice to evaluate its antidiabetic activity. Diabetic mice were ig given different dosages of HDP(50, 100 and 200 mg·kg-1)once daily for 6 weeks. The results showed that the activities were related to the dose of HDP. The fasting blood glucose level of the diabetic mice was decreased by 47.46% in 200 mg·kg-1 group compared with that of before giving HDP. Compared with that of diabetic control group, in 200 mg·kg-1 group fasting blood glucose level (decreased by 64.50%), liver and kidney coefficients(decreased by 18.12% and 30.36% respectively), the content of malondialdehyde(MDA) in liver, kidney(decreased by 44.00% and 51.27% respectively), the content of triglyceride(TG), total cholesterol(TC), low density lipoprotein cholesterol(LDL-C)in serum(decreased by 26.32%, 26.53% and 35.71% respectively) were significantly decreased; Weight(increased by 16.73%), the content of blood insulin, high density lipoprotein ...
The aim of study is to analyze the biochemical and histopathological changes of oral administration of various formulations of Morinda tinctoria leaves on alloxan induced diabetic rats. Ethanol and Ethyl acetate extracts of leaves of M.tinctoria. on serum glucose, haemoglobin, glycosylated haemoglobin (HbA1c), plasma insulin, C-peptide and urea levels were assessed and the histological changes in the liver, pancreas and kidney tissues of control and experimental groups were examined. Oral administration of ethanol and ethyl acetate extracts of Mt. for 35 days significantly reduced the levels of serum glucose, HbA1c and urea while it increases the levels of plasma insulin, haemoglobin and C-peptides. Supplementation of ethyl acetate extract of M.tinctoria extract improves histopathological alterations in the liver, pancreas and kidney. Therefore, it could be used as a natural source for prevention or early treatment of diabetes mellitus.. ...
The juice of M. charantia fruit, administered orally in different doses produced hypoglycaemia in normal and alloxan-induced diabetic rabbits. When th
The juice of M. charantia fruit, administered orally in different doses produced hypoglycaemia in normal and alloxan-induced diabetic rabbits. When th
Author for correspondence: Email: [email protected] Shubashini K. Sripathi, Poongothai G./ Bioassay- Guided Fractionation… Table 1 Anti-fungal screening result (Zone of inhibition in mm)Sample Concentrated pet-etherresidueConcentrated Table 2 Anti-fungal screening result for column fractions and for isolated compounds against Monascus purpureus Table 2 shows anti-fungal screening result for column Alloxan-induced diabetic rats. International journal fractions against Monascus purpureus and column of Applied Research in natural products. 2009; fractions 4, 5,6,7,8 and 11 showed a higher zone of inhibition than the standard Clotrimazole. The Minimum Radha R, Arokiyaraj S, Agastian P, Balaraju K, Inhibitory Concentration (MIC) values of these column Mohan Kumar R, Bula P. Phytochemical analysis fractions were also shown in Table 2. This study also and anti-inflammatory activity of Pisonia grandis revealed the potentially active fractions from which the R.Br. Journal of Biomedical and Pharmacology ...
The current studies confirm prior ones supporting the hypothesis that glucokinase is a critical regulator of neuronal activity in VMH glucosensing neurons. Prior studies demonstrated the presence of glucokinase activity (37,38), mRNA (6-8,39,40), and immunoreactive protein (41) in selective brain areas and in specific glucosensing neurons. Furthermore, pharmacological inhibition of glucokinase activity reduces [Ca2+]i oscillations in glucose-excited neurons and increases them in glucose-inhibited neurons (6,7,42), and it decreases the firing rate of glucose-excited neurons (43). On the other hand, glucokinase is probably not the only regulator of glucosensing because it is not found in all glucosensing neurons, and inhibition of glucokinase does not alter the response to glucose in all glucosensing neurons (7).. The current studies were undertaken to provide a more thorough understanding of the physiological properties of VMH glucosensing neurons and the role that glucokinase plays as a ...
Diabetes induced cardiac dysfunction and lesions are nowadays confirmed. In fact, Diabetes is a chronic metabolic disease, which is associated with oxidative stress and hyperglycaemia which have direct toxic effects on cardio-myocytes. Olive leaves extract compounds, such as Oleuropein, have been used in many therapeutic and preventive cases. The present study is designed to evaluate the effect of Oleuropein as antioxidant on the heart histological and oxidative features in diabetic rats. Diabetes was induced by alloxan at 180 mg/kg b.w by intra-peritoneal method once. Four weeks Oleuropein rich olive leaves administration restore significantly the heart histological alteration established by diabetes and enhanced the cardiac antioxidant potential.
Isolated islets of Langerhans were transplanted through the portal vein in the liver of 8 diabetic dogs; In 4 dogs a homologous transplantation was performed and another group of four dogs received isolated islets from their sisters or brothers. In both groups, there was an immediate effect on the blood glucose level. After pancreatectomy and injection of Alloxan the blood glucose rose to between 350 and 420 mg per 100 ml and after islet implantation the blood glucose decreased between 80 to 160 mg per 100 ml. The iv GTTS were after islet implantation clear better than in the diabetic control animals. These results could maintained in the recipients with homologues islets over a period of 6 to 8 weeks and in the other group of dogs over a period of 6 to 12 months. We were able to show, that the islet implantation in the liver of diabetic dogs did not disturb the microscopic architecture of the liver. No signs of portal hypertension, hepatic congestion and embolism were found. ...
Background: Anthocyanins are phytochemicals with a multitude of pharmacological actions including anti-diabetic and anti-hyperlipidemic effects. This study was undertaken to evaluate the anti-hyperglycemic and antihyperlipidemic effects of cornelian cherry (Cornus mas L., CM) fruits - that are rich in anthocyanins and known to have medicinal properties- in alloxan-induced diabetic rats. Methods: Twenty-eight adult male rats were randomly assigned to four groups of seven animals each: non-diabetic control, diabetic control, glibenclamide-treated (0.6 mg/kg/day; 4 weeks) and CM fruit-treated (2 g/day; 4 weeks) group. Diabetes was induced by a single injection of alloxan (120 mg/kg). Fasting serum levels of glucose, total cholesterol (TC), low- (LDL-C) and high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), aspartate (AST) and alanine aminotransferase (ALT) and alkaline phosphatase (ALP) were measured at the end of study period. Results: Diabetic rats had significantly elevated levels ...
Omotosho, Omolola E. and Rotimi , S.O and Rotimi, OA Persistence of acidosis in alloxan-induced diabetic rats treated with the juice of Asystasia gangetica leaves. Pharmacognosy Magazine, 7 (25). 0973-1296. ISSN 0973-1296 Omotosho, , Elizabeth Omolola and Rotimi, Solomon O. Chrysophylum albidum fruit juice reverses erythrocytes ethylene glycol-induced toxicity in male Wistar rats. Annals of Biological Research , 4 (2). 247-252 . Abdelaal, , M and Zawawi,, T.H. and al Sobhi,, E. and Jeje, O. and Gilpin, C. and Kinsara, A. and Osoba, A. and Oni, G.A. (1998) Epidemiology of hepatitis E virus in male blood donors in Jeddah, Saudi Arabia. Irish Journal of Medical Science, 167 (2). pp. 94-96. Abebe, E. F. and Akpabio, C. J. and Maduagwu, E. N. (2013) N-nitrosation of N-methylaniline and nitrosamine toxicology in the wistar rats. European Journal of Experimental Biology, 3 (3). pp. 362-369. ISSN 2248 -9215 Abodunrin, T.J and Boyo, A. O. and Usikalu, M.R. and Obafemi, L and Oladapo, O and Kotsedi, L and ...
Garlic (Allium sativum L., Alliaceae), Persian shallot (Allium ascalonicum L., Alliaceae ) and Sage (Salvia officinalis L., Lamiaceae) are believed to have hypoglycemic properties and have been used traditionally as antidiabetic herbal medicines in Iran. In this study, diabetes was induced by subcutaneous injection of alloxan monohydrate (100 mg kg−1) to male Wistar rats. Antidiabetic effects of methanolic extracts of the above mentioned three plants on alloxan-diabetic rats was investigated in comparison with the effects of antidiabetic drugs such as acarbose, glibenclamide and metformin by measuring postprandial blood glucose (PBG), oral glucose tolerance test (OGTT), inhibition of rat intestinal α-glucosidase enzymes activities and pancreatic Insulin and cardiac Glut-4 mRNAs expression. In short term period, hypoglycemic effects of A. sativum and A. ascalonicum showed significant reduction of PBG similar to glibenclamide (5 mg kg−1 bw) while S. officinalis significantly reduced PBG similar
A partially purified secretory granule fraction, isolated from rat islets of Langerhans by differential centrifugation, was used for investigating the stability of the beta granules during incubation in various conditions. Effects of pH, temperature, and time were studied; the granules possessed optimal stability at 4° and pH 6.0, and could be solubilized at pH 4.0 or 8.5, or in the presence of sodium deoxycholate, but not by phospholipase c, ouabain, or alloxan. Incubation with glucose or some of its metabolites, or with tolbutamide, ATP, or cyclic 3,5-AMP did not alter the stability of the beta granules Exogenous insulin-131I was not bound by the isolated granules under the conditions used; no specific insulin-degrading activity could be detected in subcellular fractions of the islets. These findings indicate that intracellular solubilization of the granules with subsequent diffusion of the insulin into the extracellular space is not a likely mode of insulin secretion in vivo, and suggest ...
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The association of L-type Ca(2+) channels to the secretory granules and its functional significance to secretion was investigated in mouse pancreatic B cells. Nonstationary fluctuation analysis showed that the B cell is equipped with ,500 alpha1(C) L-type Ca(2+) channels, corresponding to a Ca(2+) channel density of 0.9 channels per microm(2). Analysis of the kinetics of exocytosis during voltage-clamp depolarizations revealed an early component that reached a peak rate of 1.1 pFs(-1) (approximately 650 granules/s) 25 ms after onset of the pulse and is completed within approximately 100 ms. This component represents a subset of approximately 60 granules situated in the immediate vicinity of the L-type Ca(2+) channels, corresponding to approximately 10% of the readily releasable pool of granules. Experiments involving photorelease of caged Ca(2+) revealed that the rate of exocytosis was half-maximal at a cytoplasmic Ca(2+) concentration of 17 microM, and concentrations ,25 microM are required to ...
Anti-hyperglycemic drugs are commonly used in the treatment of diabetes. Could certain agents provide cardiovascular benefits as well?
Background and purpose: Diabetes mellitus is a metabolic disorder with several complications, such as delayed wound healing. The aim of this study was to evaluate the efficacy of oral administration and topical application of hydroalcoholic extract of Melissa officinalis on cutaneous wound healing and serum biochemical changes in alloxan-induced diabetic rats. Materials and methods: In this experimental study thirty-six Wistar rats were randomly divided into three groups of control, diabetic control, and diabetic treatment. After anesthesia, full-thickness pieces of skin (25×25 mm) were removed from upper dorsal part of the rats. Subsequently, 24 h after the operation, the wounds of the diabetic group were locally treated with topical application of 5% cream and oral administration of Melissa officinalis extract (2500 mg/kg) was performed by gavage, daily for three weeks. The control and diabetic control groups received no treatment. The wound surface areas were measured using linear and ...
Olive tree (Olea europeaea) leaves are well known for their effect on metabolism in particular as a traditional anti-diabetic and anti-hypertensive herbal drug. These properties are until now only attributed to oleuropein, the major secoiridoid of olive leaves. Here we describe the isolation and the identification of another constituent implicated in the anti-diabetic effect of this plant, i.e. oleanolic acid. We show that this triterpene is an agonist for TGR5, a member of G-protein coupled receptor activated by bile acids and which mediates some of their various cellular and physiological effect. Oleanolic acid lowers serum glucose and insulin levels in mice fed with a high fat diet and it enhances glucose tolerance. Our data suggest that both oleuropein and oleanolic acid are involved in the anti-diabetic effect of olive leaves and further emphasize the potential role of TGR5 agonists to improve metabolic disorders.. Keywords: Insulin Resistance. ...
Insulin has been demonstrated to produce many changes in metabolism in the normal and diabetic organism with such complex interrelationships that the fundamental site or sites of action of the hormone are not yet fully known. Evidence, however, from studies of isolated tissues as well as the intact animal have revealed specific stimulatory actions of insulin on glucose transport across certain cell membranes, intracellular glucose phosphorylation, glycogen synthetase, de novo synthesis of fatty acids from acetate, and mono-unsaturated fatty acid synthesis from saturated fatty acids. Since in most of these instances increased enzyme activity has followed the insulin administration, studies ...
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... - Ninhydrin (2,2-Dihydroxyindane-1,3-dione) is a chemical used to detect ammonia or primary and secondary amines. When reacting with these free amines, a deep blue or purple color known as Ruhemann
Brain insulin has had widespread metabolic, neurotrophic, and neuromodulatory functions and has been involved in the central regulation of food intake and body weight, learning and memory, neuronal development, and neuronal apoptosis. Purpose: The present study investigated the role of swimming training on cerebral metabolism on insulin concentrations in cerebellum and the body balance performance of diabetic rats. Methods: Forty Male Wistar rats were divided in four groups: sedentary control (SC), trained control (TC), sedentary diabetic (SD), and trained diabetic (TD). Diabetes was induced by alloxan (32 mg kg b.w.), single dose injection. The mean blood glucose of diabetic groups was 367 ± 40 mg/dl. Training program consisted in swimming 5 days/week, 1 h/day, 8 weeks, supporting a workload corresponding to 90% of maximal lactate steady state (MLSS). For the body balance testing rats were trained to traverse for 5 min daily for 5-7 days. All dependent variables were analyzed by one-way ...
The ninhydrin test is a test to detect proteins. According to Dr. Ian Hunt of the Department of Chemistry at the University of Calgary, it is based on the reaction between ninhydrin and amino acids...
We compared the development of sciatic nerve neuropathy in young diabetic rats with that in non-diabetic aged rats. Diabetes was induced in six-month old rats by injection with alloxan and was moderately controlled by single daily injections of insulin. Blood insulin levels in diabetic rats were significantly reduced compared to the aged animals, and glucose was significantly higher in diabetic rats. Sciatic nerve conduction velocities were measured monthly. Both motor and sensory conduction velocities decreased in the diabetic rats to a level that was similar to those in 36-month old rats. The decreases in conduction velocities in the diabetic rats were most dramatic during months 6 through 12 of diabetes. After 6 and 12 months of diabetes, sciatic nerves were examined by electron microscopy and compared to nerves from 24- and 36-month old rats respectively. Ultrastructural changes in the sciatic nerves of diabetic rats at 6 months included disruptions of myelin and dense axoplasm. In ...
Diabetes mellitus is a global metabolic epidemic affecting essential biochemical activities in almost every age group. Indian literatures like Ayurveda have already mentioned herbal remediation for a number of human ailments. Among Indian traditional medicinal plants several potential anti-diabetic plants and herbs are being used as part of our diet since prehistoric time. India has a long list of native medicinal plants with confirmed blood sugar lowering property. Some of these have proved remarkable for cure of diabetes and its complications. The current paper is aimed at providing a review on clinical and experimental studies carried out on the most effective and commonly used hypoglycemic plants and herbs species from traditional Indian flora. This write-up includes hypoglycemic and anti-hyperglycemic activities of plants, active hypoglycemic compounds and constituents along with their available toxicity status ...
BioAssay record AID 1079671 submitted by ChEMBL: Hypoglycemic activity in 18 hrs fasted Wistar albino rat assessed as reduction of blood glucose level at 10 mg/kg, po after 6 hrs (Rvb = 101.01 +/- 1.60 mg/dl).
Bera, Tushar Kanti, Kausik Chatterjee and Debidas Ghosh (2015) Remedial hypoglycemic activity of n-hexane fraction of hydro-methanol extract of seed of Swietenia mahagoni (L.) jacq. in streptozotocin-induced diabetic rat: A comparative evaluation. [Publication] Full text not available from this repository ...
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We reported that momordin Ic inhibited the gastric emptying in 10% glucose-loaded rats (Matsuda et al., 1998a), but its effects on the gastric emptying in mice after loading of nonnutrient meal, nutrient meal, and ethanol test meal and its mechanisms were unclarified. The present study demonstrated that momordin Ic (12.5-50 mg/kg) dose dependently inhibited gastric emptying in nonnutrient meal (1.5% CMC-Na test meal)-loaded mice, and also inhibited gastric emptying in animals given the nutrient meals (40% glucose test meal, milk test meal) and 60% ethanol test meal at the dose of 50 mg/kg. In addition, momordin Ic also significantly inhibited gastric emptying in mice with hyperglycemia induced by injection of glucose and with hypoglycemia induced by insulin, as well as in the alloxan- or STZ-induced diabetic mice. These results suggest that momordin Ic inhibits gastric emptying not only in normal mice but also in hyperglycemic (including diabetic) and hypoglycemic mice, and also not only in ...
Benzo[f]ninhydrin monohydrate 38627-57-5 NMR spectrum, Benzo[f]ninhydrin monohydrate H-NMR spectral analysis, Benzo[f]ninhydrin monohydrate C-NMR spectral analysis ect.
Principal Investigator:TERAKAWA Susumu, Project Period (FY):1996 - 1997, Research Category:Grant-in-Aid for Scientific Research (C), Section:一般, Research Field:General physiology
To examine the influence of preexistent diabetes mellitus on left ventricular performance and coronary blood flow responses to acute ischemia, mild normoglycemic diabetes was induced in nine mongrel dogs after three doses of alloxan, (20 mg/kg, iv), at monthly intervals. Hemodynamic measurements and coronary blood flow (85Kr clearance) were obtained before and after the onset of ischemia. This was produced by occlusion of the proximal left anterior descending coronary artery via a balloon-type catheter in nine intact anesthetized diabetic dogs and 10 nondiabetic dogs. During the 1st hour of ischemia in the diabetic group, the end-diastolic pressure rose from 7 +/- 1.1 (mean +/- SE) mm Hg to 23.8 +/- 2.3 without a significant increase of end-diastolic volume. In controls end-diastolic pressure rose from 8.6 +/- 1.1 mm Hg to 15.3 +/- 1.4, and end-diastolic volume was significantly increased, so that the ratio of end-diastolic pressure and volume was significantly higher in the diabetic group (P ...
The basis for the resistance of the female and the susceptibility of the male ICR Swiss mouse to the diabetogenicity of the D variant of encephalomyocarditis virus (EMCV-D) is unknown. This pattern of disease resistance and susceptibility can be reversed if females are treated with testosterone and males are treated with estrogen before virus infection. As a possible explanation for this sex difference in disease development, differences in early antiviral host responses were explored. Cellular antiviral resistance mechanisms operative early in virus infection were evaluated in ICR Swiss mice of both sexes after intraperitoneal infection with virus. No differences were seen in splenic natural killer (NK) cell responses of male and female mice during the 1st wk of infection, during which only the males became diabetic. Depletion of NK cell activity with rabbit anti-asialo GM1 serum did not render the infected ICR Swiss female susceptible to virus-induced diabetes. Treatment of ICR Swiss mice with type I
This multicenter, randomized, double-blind, placebo-controlled study will assess the efficacy, safety and tolerability of aleglitazar monotherapy compared with placebo in patients with type 2 diabetes mellitus who have not previously received anti-hyperglycemic therapy. Patients will be randomized to receive oral doses of 150 mcg aleglitazar once daily or placebo. The anticipated time on study treatment is 26 weeks ...
This multicenter, randomized, double-blind, placebo-controlled study will assess the efficacy, safety and tolerability of aleglitazar monotherapy compared with placebo in patients with type 2 diabetes mellitus who have not previously received anti-hyperglycemic therapy. Patients will be randomized to receive oral doses of 150 mcg aleglitazar once daily or placebo. The anticipated time on study treatment is 26 weeks ...
Vanadium compounds are potent in controlling elevated blood glucose levels in experimentally induced diabetes. However the toxicity associated with vanadium limits its role as therapeutic agent for diabetic treatment. A vanadium compound sodium orthovanadate (SOV) was given to alloxan-induced diabetic Wistar rats in lower doses in combination with Trigonella foenum graecum, a well-known hypoglycemic agent used in traditional Indian medicines. The effect of this combination was studied on lens morphology and glucose metabolism in diabetic rats. Lens, an insulin-independent tissue, was found severely affected in diabetes showing visual signs of cataract. Alterations in the activities of glucose metabolizing enzymes (hexokinase, aldose reductase, sorbitol dehydrogenase, glucose-6-phosphate dehydrogenase) and antioxidant enzymes (glutathione peroxidase, glutathione reductase) besides the levels of related metabolites, [sorbitol, fructose, glucose, thiobarbituric acid reactive species (TBARS) and ...
Compared with glucose, lactate + acetate stimulated ventricular protein synthesis in anterogradely perfused hearts from fed or 72 h-starved rats. Stimulation was greater on a percentage basis in starved rats. Atrial protein synthesis was not detectably stimulated by lactate + acetate. Insulin stimulated protein synthesis in atria and ventricles. The stimulation of protein synthesis by lactate + acetate and insulin was not additive, the percentage stimulation by insulin being less in the ventricles of lactate + acetate-perfused hearts than in glucose-perfused hearts. Perfusion of hearts from 72 h-starved or alloxan-diabetic rats with glucose + lactate + acetate + insulin did not increase protein-synthesis rates or efficiencies (protein synthesis expressed relative to total RNA) to values for fed rats, implying there is a decrease in translational activity in these hearts. In the perfused heart, inhibition of protein synthesis by starvation and its reversal by re-feeding followed a relatively ...
Evaluation of anti-hyperglycemic and anti-hyperlipidemic effects of Naravelia zeylanica in streptozotocin- induced diabetic rats
Preheat the barbecue to medium. To oven-broil: Preheat the oven to 400°F (200°C). Mix the oil with the paprika. Baste the chicken-vegetable brochettes with the flavoured oil. Grill the brochettes 4 minutes per side. The oven: put chicken brochettes on a plate, cook 12 to 15 minutes. In a frying pan, brown the shallots and peppers in the oil. Add the capers and simmer for 1 minute. Blend in the demi-glace and simmer for another 2 to 3 minutes. Adjust the seasoning. Serve the brochettes with the sauce. ...

Superoxide dismutase-inhibitible reduction of cytochrome c by the alloxan radical. Implications for alloxan cytotoxicity |...Superoxide dismutase-inhibitible reduction of cytochrome c by the alloxan radical. Implications for alloxan cytotoxicity |...

Superoxide dismutase-inhibitible reduction of cytochrome c by the alloxan radical. Implications for alloxan cytotoxicity. C C ... Superoxide dismutase-inhibitible reduction of cytochrome c by the alloxan radical. Implications for alloxan cytotoxicity ... Superoxide dismutase-inhibitible reduction of cytochrome c by the alloxan radical. Implications for alloxan cytotoxicity ... Superoxide dismutase-inhibitible reduction of cytochrome c by the alloxan radical. Implications for alloxan cytotoxicity ...
more infohttp://www.biochemj.org/content/207/3/609

Alloxan Monohydrate  Manufacturers, Suppliers, Exporters, Dealers in Sangli, IndiaAlloxan Monohydrate Manufacturers, Suppliers, Exporters, Dealers in Sangli, India

Get Information of Alloxan Monohydrate Manufacturers, Suppliers, Dealers, Exporters, Traders, Producers, Wholesalers, Alloxan ... Alloxan Monohydrate Alloxan Tetrahydrate Alprazolam Aluminium Chloride Hexahydrate Aluminium Hydroxide Gel Ambroxol ... Alloxan Monohydrate Manufacturers Suppliers Exporters About 0 results View other Companies making Related Products Did You Mean ...
more infohttp://www.sanglibusiness.com/Products/SearchResult?ProductName=alloxan-monohydrate

Fatty acid composition and lipid peroxidation in brain microsomes of albino rats with alloxan diabetesFatty acid composition and lipid peroxidation in brain microsomes of albino rats with alloxan diabetes

Abstract: Fatty acid composition and lipid peroxidation in rat brain microsomes were studied under conditions of alloxan ... Fatty acid composition and lipid peroxidation in brain microsomes of albino rats with alloxan diabetes. ... Fatty acid composition and lipid peroxidation in brain microsomes of albino rats with alloxan diabetes, Voprosy meditsinskoi ...
more infohttp://pbmc.ibmc.msk.ru/index.php/en/article/PBMC-1985-31-3-86-en

Effects of Diabetes Mellitus Induced by Alloxan on the Pharmacokinetics of Metformin in Rats: Restoration of Pharmacokinetic...Effects of Diabetes Mellitus Induced by Alloxan on the Pharmacokinetics of Metformin in Rats: Restoration of Pharmacokinetic...

Effects of Diabetes Mellitus Induced by Alloxan on the Pharmacokinetics of Metformin in Rats: Restoration of Pharmacokinetic ... To test the effect of insulin treatment on the pharmacokinetics of metformin in rats with diabetes mellitus induced by alloxan ... Effects of Diabetes Mellitus Induced by Alloxan on the Pharmacokinetics of Metformin in Rats: Restoration of Pharmacokinetic ...
more infohttps://journals.library.ualberta.ca/jpps/index.php/jpps/article/view/1608

Postoperative changes in the lipid content of the liver, placenta and embryo of normal, alloxan diabetic and insulin-treated...Postoperative changes in the lipid content of the liver, placenta and embryo of normal, alloxan diabetic and insulin-treated...

... alloxan diabetic and insulin-treated rats]. by W Haude et al. ... alloxan diabetic and insulin-treated rats].. *. W Haude. , ... alloxan diabetic and insulin-treated rats].}, author={W Haude and Eberhardt Goetze and Kurt Malberg}, journal={Acta biologica ...
more infohttps://www.semanticscholar.org/paper/Postoperative-changes-in-the-lipid-content-of-the-Haude-Goetze/203712adc107927f867480a1f4e5b235b9b0286a

Alloxan - WikipediaAlloxan - Wikipedia

Alloxan, sometimes referred to as alloxan hydrate, refers to the organic compound with the formula OC(N(H)CO)2C(OH)2. It is ... The name "Alloxan" emerged from an amalgamation of the words "allantoin" and "Oxalsäure" (oxalic acid). The alloxan model of ... Studies suggests that alloxan does not cause diabetes in humans. Others found a significant difference in alloxan plasma levels ... A dimeric derivative alloxantin can be prepared by partial reduction of alloxan with hydrogen sulfide. Alloxan is a toxic ...
more infohttps://en.wikipedia.org/wiki/Alloxan

Third Ventricular Alloxan Reversibly Impairs Glucose Counterregulatory Responses | DiabetesThird Ventricular Alloxan Reversibly Impairs Glucose Counterregulatory Responses | Diabetes

5TG 14d post-Alloxan) after 3v alloxan. Data are means ± SEM. *P ≤ 0.05 vs. 5TG responses prior to 3v alloxan injection. ... 7-day post-3v alloxan-treated (B), and 14-day post-3v alloxan-treated (C) rats. Seven days following 3v alloxan injection, GFAP ... Experiment 2: 4v alloxan: feeding and blood glucose responses.. There were no effects of 4v alloxan on systemic 2DG-induced ... alloxan: 436 ± 8 g) nor body weight gain (saline: 101 ± 6 vs. alloxan: 95 ± 9 g) differed at the termination of the experiment ...
more infohttp://diabetes.diabetesjournals.org/content/53/5/1230?ijkey=f5b7b31424849b2d5bd9f4c1dd9430c28a2c0fa3&keytype2=tf_ipsecsha

Alloxan is an inhibitor of the enzyme O-linked N-acetylglucosamine transferase.  - PubMed - NCBIAlloxan is an inhibitor of the enzyme O-linked N-acetylglucosamine transferase. - PubMed - NCBI

... suggesting that alloxan indeed was inhibiting (OGT). In order to show definitively that alloxan was inhibiting OGT activity, ... Alloxan is an inhibitor of the enzyme O-linked N-acetylglucosamine transferase.. Konrad RJ1, Zhang F, Hale JE, Knierman MD, ... Alloxan, another beta-cell toxin is a uracil analog. Since the O-GlcNAc transferase (OGT) uses UDP-GlcNAc as a substrate, we ... Together, these data demonstrate that alloxan is an inhibitor of OGT, and as such, is the first OGT inhibitor described. ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/12054585?dopt=Abstract

Antidiabetic effect of Artemisia absinthium extracts on alloxan-induced diabetic rats | SpringerLinkAntidiabetic effect of Artemisia absinthium extracts on alloxan-induced diabetic rats | SpringerLink

... ethanol extract on alloxan-induced diabetic rats. Forty-eight albino rats (300 g) were used in this experiment... ... Alloxan Diabetes A. absinthium Blood glucose Antihyperglycemic effect Biochemical markers This is a preview of subscription ... Lenzen S (2008) The mechanisms of alloxan and streptozotocin induced diabetes. Diabetologica 51:216-226CrossRefGoogle Scholar ... The aim of our study was to evaluate the effect of Artemisia absinthium (A. absinthium) ethanol extract on alloxan-induced ...
more infohttps://link.springer.com/article/10.1007%2Fs00580-014-1963-1

Rejuvenating of Kidney Tissues on Alloxan Induced Diabetic Mice under the Effect of Momordica charantiaRejuvenating of Kidney Tissues on Alloxan Induced Diabetic Mice under the Effect of Momordica charantia

Alloxan is most commonly used to induce diabetes in animals.. Alloxan is a β-cytotoxin and induces diabetes mellitusby damaging ... alloxan 150 mg/kg body weight i.p.); Group III: diabetic control (B) (alloxan 150 mg/kg body weight i.p.) + C (Momordica ... In this study significant hyperglycemia was achieved after alloxan (150 mg/kg body weight) injection. Alloxan induced diabetic ... In alloxan treated diabetic group, the mean value was mg/dL with individual level variations ranging from 1.11 to 1.55 mg/dL, ...
more infohttps://www.hindawi.com/journals/ap/2014/439158/

The Effect of Food Hardness on the Development of Dental Caries in Alloxan-Induced Diabetic RatsThe Effect of Food Hardness on the Development of Dental Caries in Alloxan-Induced Diabetic Rats

... Yutaka Nakahara,1 Tomoya Sano ... intact rats fed with a standard pelletized or powdered diet and alloxan-induced diabetic rats fed with a standard pelletized or ...
more infohttps://www.hindawi.com/journals/jdr/2013/787084/abs/

The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas.The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas.

Abstract Alloxan and streptozotocin are widely used to induce experimental diabetes in animals. The mechanism of their action ... the source of their generation is different in the case of alloxan and streptozotocin. Alloxan and the product of its reduction ... Abstract Alloxan and streptozotocin are widely used to induce experimental diabetes in animals. The mechanism of their action ... The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas.. ...
more infohttps://www.omicsonline.org/references/the-mechanism-of-alloxan-and-streptozotocin-action-in-b-cells-of-the-rat-pancreas-1319105.html

Corneal Lymphatics in Alloxan Vascularized Rabbit Eyes | IOVS | ARVO JournalsCorneal Lymphatics in Alloxan Vascularized Rabbit Eyes | IOVS | ARVO Journals

Corneal Lymphatics in Alloxan Vascularized Rabbit Eyes You will receive an email whenever this article is corrected, updated, ... Alloxan monohydrate was injected into the anterior chamber of normal rabbit eyes and resulted in extensive vascularization of ... H. BARRY COLLIN; Corneal Lymphatics in Alloxan Vascularized Rabbit Eyes. Invest. Ophthalmol. Vis. Sci. 1966;5(1):1-13. ...
more infohttps://iovs.arvojournals.org/article.aspx?articleid=2203594

Post-Heparin Lipolytic Activity and Tissue Lipoprotein Lipase Activity in the Alloxan-Diabetic Rat | Clinical SciencePost-Heparin Lipolytic Activity and Tissue Lipoprotein Lipase Activity in the Alloxan-Diabetic Rat | Clinical Science

Post-Heparin Lipolytic Activity and Tissue Lipoprotein Lipase Activity in the Alloxan-Diabetic Rat. R. S. Elkeles, E. Williams ... 1. Alloxan-diabetic rats showed raised plasma triglyceride levels and low adipose tissue lipoprotein lipase activity compared ... Post-Heparin Lipolytic Activity and Tissue Lipoprotein Lipase Activity in the Alloxan-Diabetic Rat ... Post-Heparin Lipolytic Activity and Tissue Lipoprotein Lipase Activity in the Alloxan-Diabetic Rat ...
more infohttp://www.clinsci.org/content/46/5/661

Therapeutic effect of vitamin B3 on hyperglycemia, oxidative stress and DNA damage in alloxan induced diabetic rat model.  -...Therapeutic effect of vitamin B3 on hyperglycemia, oxidative stress and DNA damage in alloxan induced diabetic rat model. -...

Therapeutic effect of vitamin B3 on hyperglycemia, oxidative stress and DNA damage in alloxan induced diabetic rat model.. ... This study reports the effects of niacin supplementation in alloxan induced diabetic rats divided into five groups. Diabetes ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/30021358

Genistein Reduces Hyperglycemia and Islet Cell Loss in a High-dosage Manner in Rats with Alloxan-induced Pancreatic DamageGenistein Reduces Hyperglycemia and Islet Cell Loss in a High-dosage Manner in Rats with Alloxan-induced Pancreatic Damage

... http ... Alloxan-induced Pancreatic Damage This section is compiled by Frank M. Painter, D.C.. Send all comments or additions to: Frankp ... METHODS: Alloxan-induced diabetic male Sprague-Dawley rats were randomly divided into 5 groups (10 rats per group) and treated ... In addition, rat islets were isolated, cultured, and exposed to alloxan in the presence or absence of genistein. The survival ...
more infohttp://www.chiro.org/nutrition/ABSTRACTS/Genistein_Reduces_Hyperglycemia.shtml

Hypoglycemic Activity And Regeneration Of Pancreatic Beta-cells Produced By Allium Cepa In Alloxan-induced Diabetic RatsHypoglycemic Activity And Regeneration Of Pancreatic Beta-cells Produced By Allium Cepa In Alloxan-induced Diabetic Rats

Methods: Alloxan-induced diabetic rats? model was conducted to demonstrate the effects of the oral administration of Allium ... Furthermore, it?s clinical improvement and/or increased survival rates in alloxan-induced diabetic rats were evident and it was ... Hypoglycemic activity and regeneration of pancreatic beta-cells produced by Allium cepa in alloxan-induced diabetic rats. ...
more infohttps://www.omicsonline.org/proceedings/hypoglycemic-activity-and-regeneration-of-pancreatic-betacells-produced-by-allium-cepa-in-alloxaninduced-diabetic-rats-24957.html

The use of alloxan and streptozotocin in experimental diabetes models / Deneysel Diyabet Modellerinde Alloksan ve...The use of alloxan and streptozotocin in experimental diabetes models / Deneysel Diyabet Modellerinde Alloksan ve...

The use of alloxan and streptozotocin in experimental diabetes models by Turkish Journal of Endocrinology and Metabolism; ... Selective uptake of alloxan by pancreatic B-cells. Biochem J 1982;208:513-5. (11.) Lenzen S, Mirzaie-Petri M. Inhibition of ... Role of Ca2+ in alloxan-induced pancreatic beta-cell damage. Biochim Biophys Acta 1994;1227:87-91. (15.) Golfman L, Dixon IM, ... The use of alloxan and streptozotocin in experimental diabetes models / Deneysel Diyabet Modellerinde Alloksan ve ...
more infohttps://www.thefreelibrary.com/The+use+of+alloxan+and+streptozotocin+in+experimental+diabetes+models+...-a0349741337

Silica inflammation modulates lipoperoxide and thi-obarbituric acid reactive substances levels in liver and glucose...Silica inflammation modulates lipoperoxide and thi-obarbituric acid reactive substances levels in liver and glucose...

2) Alloxan diabetic rats (DB rats);. 3) Alloxan diabetics rats in which silica granulomatous inflammation was induced 8 days ... Adrenocortical system activity in alloxan-resistant and alloxan-susceptible Wistar rats. Journal of Diabetes Mellitus, 2, 165- ... Seven days after alloxan injection, daily urine was collected individually from each animal with special urine collectors, its ... As a result, the daily excretion of glucose in the group of alloxan diabetic rats selected for further study was 4.8 ± 0.5 g/ ...
more infohttps://www.scirp.org/html/1-2640007_24882.htm

Antidiabetic and antihyperlipidemic potential of ethanol extract of Salacia lehmbachii stem bark in alloxan-induced diabetic...Antidiabetic and antihyperlipidemic potential of ethanol extract of Salacia lehmbachii stem bark in alloxan-induced diabetic...

Results Treatment of alloxan-induced diabetic rats with S. lehmbachii stem bark extract showed significant (p<0.01) reduction ... lehmbachii ethanol stem bark extract was evaluated in alloxan-induced diabetic rats at a dose of 100 mg/kg, 200 mg/kg, and 400 ... Treatment of alloxan-induced diabetic rats with S. lehmbachii stem bark extract showed significant (p,0.01) reduction in blood ... Liu Z, Li J, Zeng Z, Liu M, Wang M. The antidiabetic effects of cysteinyl metformin, a newly synthesized agent, in alloxan- and ...
more infohttps://www.degruyter.com/view/j/jbcpp.ahead-of-print/jbcpp-2018-0059/jbcpp-2018-0059.xml

Reversal of D- and A-Cell Insensitivity to Glucose in Alloxan-diabetic Dogs by Treatment with the Artificial Beta Cell ...Reversal of D- and A-Cell Insensitivity to Glucose in Alloxan-diabetic Dogs by Treatment with the Artificial Beta Cell ...

Reversal of D- and A-Cell Insensitivity to Glucose in Alloxan-diabetic Dogs by Treatment with the Artificial Beta Cell ( ... In contrast, treatment of alloxan-diabetic dogs (N = 3) by a GCIIS for 24 h revived some responsiveness of the glucagon, ... Reversal of D- and A-Cell Insensitivity to Glucose in Alloxan-diabetic Dogs by Treatment with the Artificial Beta Cell ( ... Reversal of D- and A-Cell Insensitivity to Glucose in Alloxan-diabetic Dogs by Treatment with the Artificial Beta Cell ( ...
more infohttp://diabetes.diabetesjournals.org/content/34/3/260

NOPR: Reduced nociceptive responses in mice with alloxan induced hyperglycemia after garlic (Allium sativum Linn.) treatmentNOPR: Reduced nociceptive responses in mice with alloxan induced hyperglycemia after garlic (Allium sativum Linn.) treatment

Administration of ethanol (95%) extract (45 mg/kg body wt/day for 28 days) of garlic (A.sativum) to alloxan induced diabetic ( ... Reduced nociceptive responses in mice with alloxan induced hyperglycemia after garlic (Allium sativum Linn.) treatment. ...
more infohttp://nopr.niscair.res.in/handle/123456789/19100

Changes in Body Weight and Serum Biochemical Measures of German Shepherd Dogs following Alloxan Induced Diabetes MellitusChanges in Body Weight and Serum Biochemical Measures of German Shepherd Dogs following Alloxan Induced Diabetes Mellitus

alloxan induced diabetic rats. Am. J. Drug Discov. Dev., 2: 135-142.. CrossRef , Direct Link , Kim, J.S., J.B. Ju, C.W. Choi ... leaf extracts in alloxan-induced diabetic rats. Iran. J. Pharmacol. Ther., 4: 36-39.. Direct Link , Ahmida, M., 2011. ... Then after 5 days, 100 mg kg-1 of Alloxan monohydrate (Sigma®) was injected (IV). A week later, the second IVGTT was done and ... Alloxan monohydrate with 100 mg kg-1 in was injected intravenously for experimental group. After weighting, the blood samples ...
more infohttps://scialert.net/fulltext/?doi=ajb.2012.232.236&org=10
  • AlarconA FJ, Roman RR, Flores S JL, Aguirre GF (2002) Investigation on the hypoglycaemic effects of extracts of four Mexican medicinal plants in normal and alloxan-diabetic mice. (springer.com)
  • Diabetes was induced in the Swiss albino mice by injecting alloxan at the dose of 150 mg/kg body weight and aqueous extract of Momordica charantia fruits at doses of 100 mg/kg body weight and 250 mg/kg body weight was administered orally for three weeks. (hindawi.com)
  • Thus, from this study we concluded that Momordica charantia exhibited significant antihyperglycemic and rejuvenating capacity of kidney tissues activities in alloxan induced diabetic mice. (hindawi.com)
  • Liraglutide improves pancreatic Beta cell mass and function in alloxan-induced diabetic mice. (nih.gov)
  • Here we clarify the effects of the human GLP-1 analog liraglutide on beta cell fate and function by using an inducible Cre/loxP-based pancreatic beta cell tracing system and alloxan-induced diabetic mice. (nih.gov)
  • Metabolic parameters in alloxan-diabetic mice treated with vehicle or liraglutide for 30 days. (nih.gov)
  • Ten days after the last injection of tamoxifen, alloxan (Sigma-Aldrich) was administered intraperitoneally to the mice at 60 mg/kg body weight. (nih.gov)
  • DETAPAC, an Fe-chelating agent, given to male Swiss-Webster mice prior to alloxan, was able to protect the mice from the diabetogenic actions of alloxan. (eurekamag.com)
  • To understand the role of GK in glucoprivic counterregulatory responses, we injected alloxan, a GK inhibitor and toxin, into the third ventricle (3v) to target nearby GK-expressing neurons. (diabetesjournals.org)
  • Alloxan is an inhibitor of the enzyme O-linked N-acetylglucosamine transferase. (nih.gov)
  • Together, these data demonstrate that alloxan is an inhibitor of OGT, and as such, is the first OGT inhibitor described. (nih.gov)
  • Alloxan, another beta-cell toxin is a uracil analog. (nih.gov)
  • Most studies have shown that alloxan is not toxic to the human beta-cell, even in very high doses, probably because of differing glucose uptake mechanisms in humans and rodents. (wikipedia.org)
  • Alloxan is, however, toxic to the liver and the kidneys in high doses. (wikipedia.org)
  • Because there have been conflicting studies implicating the hypothalamus ( 28 - 31 ) or hindbrain ( 18 , 32 , 33 ) as primary mediators of the CRR to glucose deficit, we also compared the effects of toxic doses of alloxan administered into the third ventricle (3v) versus the fourth ventricle (4v) on glucoprivic CRRs. (diabetesjournals.org)
  • Under these conditions, OGT activity was completely inhibited by 1 mM alloxan with half-maximal inhibition achieved at a concentration of 0.1 mM alloxan. (nih.gov)
  • The inhibition constant ( K i ) for alloxan-induced inhibition on δ-ALA-D was 3.64 μM. (springer.com)
  • The alloxan (5 μM) caused a decrease in V max (65.8%) and in K m (53.1%), which is suggestive of an uncompetitive inhibition of enzyme. (springer.com)
  • In addition, dithiothreitol (700 and 1,000 μM) completely prevented the δ-ALA-D activity inhibition induced by 10 and 20 μM alloxan. (springer.com)
  • Therefore, this work showed that the inhibition of hepatic δ-ALA-D activity can be obtained in vitro at low micromolar levels of alloxan, and can also be prevented by reducing agents. (springer.com)
  • Thus, neural substrates near and around the 3v affected by alloxan may be critically involved in the expression of these glucoprivic responses. (diabetesjournals.org)
  • This study evaluated the effects of alloxan on the kinetics properties of the δ-aminolevulinate dehydratase (δ-ALA-D) using mouse liver homogenates. (springer.com)
  • Others found a significant difference in alloxan plasma levels in children with and without diabetes Type 1. (wikipedia.org)
  • Since the O-GlcNAc transferase (OGT) uses UDP-GlcNAc as a substrate, we investigated whether alloxan might interfere with the process of protein O-glycosylation by blocking OGT, a very abundant enzyme in beta-cells. (nih.gov)
  • In isolated pancreatic islets, alloxan almost completely blocked both glucosamine-induced and STZ-induced protein O-GlcNAcylation, suggesting that alloxan indeed was inhibiting (OGT). (nih.gov)
  • In addition, rat islets were isolated, cultured, and exposed to alloxan in the presence or absence of genistein. (chiro.org)
  • Alloxan was used in the production of the purple dye murexide, discovered by Carl Wilhelm Scheele in 1776. (wikipedia.org)