Alloxan is a chemical compound, specifically an organic compound, that is used in scientific research to induce diabetes in laboratory animals by destroying their insulin-producing cells in the pancreas.
2,2-Dihydroxy-1H-indene-1,3-(2H)-dione. Reagent toxic to skin and mucus membranes. It is used in chemical assay for peptide bonds, i.e., protein determinations and has radiosensitizing properties.
Diabetes mellitus induced experimentally by administration of various diabetogenic agents or by PANCREATECTOMY.
A plant genus of the family FABACEAE.
Irregular microscopic structures consisting of cords of endocrine cells that are scattered throughout the PANCREAS among the exocrine acini. Each islet is surrounded by connective tissue fibers and penetrated by a network of capillaries. There are four major cell types. The most abundant beta cells (50-80%) secrete INSULIN. Alpha cells (5-20%) secrete GLUCAGON. PP cells (10-35%) secrete PANCREATIC POLYPEPTIDE. Delta cells (~5%) secrete SOMATOSTATIN.
Glucose in blood.
The appearance of an abnormally large amount of GLUCOSE in the urine, such as more than 500 mg/day in adults. It can be due to HYPERGLYCEMIA or genetic defects in renal reabsorption (RENAL GLYCOSURIA).
An antibiotic that is produced by Stretomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.

Accelerated intimal hyperplasia and increased endogenous inhibitors for NO synthesis in rabbits with alloxan-induced hyperglycaemia. (1/243)

1. We examined whether endogenous inhibitors of NO synthesis are involved in the augmentation of intimal hyperplasia in rabbits with hyperglycaemia induced by alloxan. 2. Four weeks after the endothelial denudation of carotid artery which had been performed 12 weeks after alloxan, the intimal hyperplasia was greatly augmented with hyperglycaemia. The degree of hyperplasia was assessed using three different parameters of histopathological findings as well as changes in luminal area and intima: media ratio. 3. There were positive and significant correlations between intima:media ratio, plasma glucose, and concentrations of N(G)-monomethyl-L-arginine (L-NMMA) and N(G), N(G)-dimethyl-L-arginine (ADMA) in endothelial cells, that is, the intima:media ratio became greater as plasma glucose and endothelial L-NMMA and ADMA were increased. Furthermore, endothelial L-NMMA and ADMA were increased in proportion to the increase in plasma glucose. 4. In contrast, there were inverse and significant correlations between cyclic GMP production by carotid artery strips with endothelium and plasma glucose, between cyclic GMP production and endothelial L-NMMA and ADMA, and between the intima:media ratio and cyclic GMP production. 5. Exogenously applied L-NMMA and ADMA inhibited cyclic GMP production in a concentration-dependent manner. IC50 values were determined to be 12.1 microM for the former and 26.2 microM for the latter. The cyclic GMP production was abolished after the deliberate removal of endothelium from the artery strips. 6. These results suggest that the augmentation of intimal hyperplasia with hyperglycaemia is closely related to increased accumulation of L-NMMA and ADMA with hyperglycaemia, which would result in an accelerated reduction in NO production/release by endothelial cells.  (+info)

Alloxan in vivo does not only exert deleterious effects on pancreatic B cells. (2/243)

The aim of the experiment was to investigate the mechanism of harmful alloxan action in vivo. 75 mg/kg b.w. of this diabetogenic agent were administered to fasting rats. Two minutes later the animals were decapitated. It was observed that alloxan caused a distinct rise in blood insulin and glucose levels with a concomitant drop of free fatty acids. The amount of sulfhydryl groups in the liver of alloxan-treated rats was decreased and glutathione peroxidase activity was substantially higher. These results indicate that some changes observed in alloxan-induced diabetes can not only be the consequence of B cells damage by alloxan but may also be the result of its direct influence on other tissues. It was also observed that glucose given 20 min before alloxan injection only partially protected against the deleterious effects of alloxan.  (+info)

Intercalated duct cells in the chicken pancreatic islet with special reference to the alloxan administration. (3/243)

The intercalated duct cells were observed in the A and B islets of the chicken pancreas. These cells adhered with each other by intercellular junctional complexes at the apical side. They had many microvilli projecting into the lumen. Abluminally, they displayed extended slender cytoplasmic processes between islet endocrine cells. Administration of alloxan resulted to denser cytoplasm and a more prominent thickening of cytoplasmic processes of the intercalated duct cells, although the blood glucose levels did not show appreciable changes by the treatment. The intercalated duct epithelial cells appeared clearly as stellate cells. The lysosomes increased in size and number with passage of time after alloxan administration. The present findings may suggest that intercalated ducts are not only anatomically important as a structure passing through the islet but also play physiologically by protecting the islet endocrine cells.  (+info)

Reduced coronary NO production in conscious dogs after the development of alloxan-induced diabetes. (4/243)

The role of nitric oxide (NO) in the control of coronary blood flow (CBF) during the development of diabetes is unknown. To study this, mongrel dogs were chronically instrumented using sterile techniques for measurements of systemic hemodynamics and CBF. With heart rate controlled (150 beats/min), veratrine (1-10 micrograms/kg) caused dose-dependent increases in CBF; e.g., 5 mirograms/kg of veratrine increased CBF by 57 +/- 7% from 41 +/- 1.3 ml/min (P < 0.05). The dogs developed diabetes 4-5 wk after injection of alloxan (40-60 mg/kg iv, blood glucose levels were 384 +/- 18 mg/dl). After diabetes the same doses of veratrine caused smaller increases in CBF; i.e., 5 micrograms/kg of veratrine increased CBF by 32 +/- 2% (P < 0.05 compared with control) from 28 +/- 4 ml/min. ACh- and adenosine-induced coronary vasodilation were reduced after diabetes as well. In anesthetized dogs after diabetes, vagal stimulation caused smaller increases in CBF. ACh and bradykinin caused smaller increases in NO(-)(2) production in coronary microvessels from diabetic dogs. Furthermore, despite the fact that mRNA for endothelial cell NO synthase from the aorta was increased twofold with the use of Northern blotting, the protein for aortic endothelial constitutive NO synthase was reduced by 66% after diabetes, as determined by Western blotting. Our results indicate that the NO-dependent coronary vasodilation by the Bezold-Jarisch reflex is impaired in conscious dogs after diabetes. The mechanism responsible for the impaired endothelium-dependent coronary vasodilation is most likely the decreased release of NO from the endothelium.  (+info)

Supplementation of N-acetylcysteine inhibits NFkappaB activation and protects against alloxan-induced diabetes in CD-1 mice. (5/243)

Reactive oxygen species (ROS) are involved in the destruction of pancreatic beta cells and the development of insulin-dependent diabetes mellitus (IDDM). However, the cellular mechanism responsible for beta cell death is still unclear. We hypothesize that activation of NFkappaB by ROS is the key cellular signal in initiating a cascade of events leading to beta cell death. Thus, enhancement of pancreatic GSH, a known antioxidant and key regulator of NF-kappaB, should protect against IDDM. Weanling CD1 mice (n=5) were injected with alloxan (50 mg/kg i.v.) to induce IDDM. Using EPR spin trapping techniques, we demonstrated that alloxan generated ROS in the pancreas 15 min after administration. Activation of NFkappaB in pancreatic nuclear extracts was observed 30 min after alloxan injection, as assessed by an electrophoretic mobility shift assay. Fasting blood glucose levels were monitored for 14 days. Supplementation with N-acetylcysteine (NAC, 500 mg/kg), a GSH precursor, inhibited alloxan-induced NFkappaB activation and reduced hyperglycemia. Thus, NFkappaB activation by ROS may initiate a sequence of events leading to IDDM. Inhibition of NF-kappaB activation by NAC attenuated the severity of IDDM. This research will contribute to the understanding of the etiology of IDDM and may lead to the development of better strategies for disease prevention.  (+info)

Lipolysis induced by alloxan in rat adipocytes is not inhibited by insulin. (6/243)

Isolated rat adipocytes were incubated with adrenaline, adrenaline plus insulin, alloxan or alloxan plus insulin. Glycerol release was taken as a measure of lipolysis. It was observed that alloxan in the concentration of 3, 10 and 20 mmol/l intensifies lipolysis in adipocytes in the absence of adrenaline. Insulin (10(-6) mol/l) treatment of cells did not inhibit lipolysis caused by this compound, but significantly restricted lipolysis induced by adrenaline (10(-6) mol/l). It was also shown that alloxan in the concentration of 3 and 10 mmol/l intensified lipolysis stimulated by adrenaline (10(-6) mol/l). Addition of 20 mmol/l of alloxan strongly inhibited glycerol release in the presence of adrenaline. The results presented here clearly indicate that the action of alloxan concerns cells of the white adipose tissue.  (+info)

Resistance of ALR/Lt islets to free radical-mediated diabetogenic stress is inherited as a dominant trait. (7/243)

ALS/Lt and ALR/Lt are inbred mouse strains selected for susceptibility and resistance to alloxan (AL)-induced diabetes. Within 24-h after AL administration in vivo, ALS/Lt islets were distinguished from ALR/Lt islets by more extensive necrotic changes. Within 7 days post-AL, ALS/Lt mice exhibited hyperglycemia and hypoinsulinemia, whereas ALR/Lt mice maintained normal plasma insulin and glucose levels. We have recently shown that resistance in ALR/Lt correlated with constitutively elevated systemic (and pancreatic) free radical defense status. In the present report, we examined whether ability to detoxify free radical stress extended to the level of ALR/Lt pancreatic islets. Cultured ALS/Lt islets exposed for 5 min to increasing (0-3 mmol/l) AL concentrations in vitro exhibited an 80% decline in numbers of intact islets after a subsequent 6-day culture period, as well as a 75% reduction in islet insulin content and a 94% decrease in glucose-stimulated insulin secretory capacity. In contrast, ALR/Lt islets remained viable and retained glucose-stimulated insulin secretory capacity as well as normal insulin content. This ALR/Lt islet resistance extended to hydrogen peroxide, a free radical generator whose entry into beta-cells is not dependent on glucose transporters. The elevated antioxidant defenses previously found in ALR/Lt pancreas were extended to isolated islets, which exhibited significantly higher glutathione and Cu-Zn superoxide dismutase 1 levels compared with ALS/Lt islets. A dominant genetic trait from ALR/Lt controlling this unusual AL resistance was indicated by the finding that reciprocal F1 mice of both sexes were resistant to AL administration in vivo. A backcross to ALS/Lt showed 1:1 segregation for susceptibility/resistance, indicative of a single gene controlling the phenotype. In conclusion, the ALR/Lt mouse may provide important insight into genetic mechanisms capable of rendering islets strongly resistant to free radical-mediated damage.  (+info)

Protective mechanism of glucose against alloxan-induced beta-cell damage: pivotal role of ATP. (8/243)

Glucose prevents the development of diabetes induced by alloxan. In the present study, the protective mechanism of glucose against alloxan-induced beta-cell damage was investigated using HIT-T 15 cell, a Syrian hamster transformed beta-cell line. Alloxan caused beta-cell damages with DNA fragmentation, inhibition of glucose-stimulated insulin release, and decrease of cellular ATP level, but all of these beta-cell damages by alloxan were prevented by the presence of 20 mM glucose. Oligomycin, a specific inhibitor of ATP synthase, completely abolished the protective effects of glucose against alloxan-induced cell damage. Furthermore, treatment of nuclei isolated from HIT-T15 cells with ATP significantly prevented the DNA fragmentation induced by Ca2+. The results indicate that ATP produced during glucose metabolism plays a pivotal role in the protection of glucose against alloxan-induced beta-cell damage.  (+info)

Alloxan is a chemical compound that is primarily used in laboratory research. Its medical definition is:

A toxic, crystalline substance, C6H4O6, derived from uric acid, and used experimentally to produce diabetes in animals by destroying their insulin-producing cells (beta cells) in the pancreas. Alloxan monohydrate is a white crystalline powder that is soluble in water and alcohol. It is used as a reagent in analytical chemistry and in photography.

In scientific research, alloxan is often used to induce diabetes in laboratory animals (like rats and mice) in order to study the disease and potential treatments. The compound is toxic to the insulin-producing beta cells in the pancreas, leading to a decrease in insulin production and an increase in blood glucose levels, similar to what occurs in type 1 diabetes in humans. However, it's important to note that alloxan-induced diabetes does not perfectly mimic the human form of the disease, and results from such studies may not always translate directly to human treatments.

Ninhydrin, also known as reagent Triketohydrindene hydrate or by its chemical name 2,2-Dihydroxyindane-1,3-dione, is not a medical term itself but a reagent used in various scientific fields including forensic science and biochemistry. In the medical field, it is primarily used as a colorimetric reagent to detect and quantify amino acids and other related compounds.

When ninhydrin comes into contact with certain amino acids or their derivatives, such as primary amines, it forms a purple-colored complex called a Ruhemann's purple. This reaction is specific to certain functional groups (α-amino acids) and can be used for the detection and quantification of these compounds in various samples, including biological fluids like urine or blood.

In summary, Ninhydrin is not a medical term itself but a reagent that has applications in detecting and quantifying specific compounds within the medical field.

I couldn't find a medical definition specifically for "Diabetes Mellitus, Experimental." However, I can provide you with information about experimental diabetes research and its relevance to understanding the disease.

Experimental diabetes models are used in biomedical research to study the pathophysiology of diabetes mellitus and to test potential therapies or treatments. These models can be broadly categorized into two types: chemically-induced and genetically modified.

1. Chemically-induced diabetes models: These involve administering chemicals, such as alloxan or streptozotocin, to animals (commonly mice or rats) to destroy their pancreatic β-cells, which produce insulin. This results in hyperglycemia and symptoms similar to those seen in type 1 diabetes in humans.
2. Genetically modified diabetes models: These involve altering the genes of animals (commonly mice) to create a diabetes phenotype. Examples include non-obese diabetic (NOD) mice, which develop an autoimmune form of diabetes similar to human type 1 diabetes, and various strains of obese mice with insulin resistance, such as ob/ob or db/db mice, which model aspects of type 2 diabetes.

These experimental models help researchers better understand the mechanisms behind diabetes development and progression, identify new therapeutic targets, and test potential treatments before moving on to human clinical trials. However, it's essential to recognize that these models may not fully replicate all aspects of human diabetes, so findings from animal studies should be interpreted with caution.

"Trigonella" is the genus name for a group of plants in the Fabaceae (legume) family, which includes many species such as fenugreek (Trigonella foenum-graecum). Fenugreek is an herb that has been used in traditional medicine and cooking for centuries. The seeds, leaves, and roots of fenugreek are used in various forms including powder, tea, or supplements for their potential health benefits. However, it's important to note that while some studies suggest possible advantages, more research is needed to confirm these effects and establish appropriate dosages and safety guidelines. As always, consult with a healthcare provider before starting any new supplement regimen.

The Islets of Langerhans are clusters of specialized cells within the pancreas, an organ located behind the stomach. These islets are named after Paul Langerhans, who first identified them in 1869. They constitute around 1-2% of the total mass of the pancreas and are distributed throughout its substance.

The Islets of Langerhans contain several types of cells, including:

1. Alpha (α) cells: These produce and release glucagon, a hormone that helps to regulate blood sugar levels by promoting the conversion of glycogen to glucose in the liver when blood sugar levels are low.
2. Beta (β) cells: These produce and release insulin, a hormone that promotes the uptake and utilization of glucose by cells throughout the body, thereby lowering blood sugar levels.
3. Delta (δ) cells: These produce and release somatostatin, a hormone that inhibits the release of both insulin and glucagon and helps regulate their secretion in response to changing blood sugar levels.
4. PP cells (gamma or γ cells): These produce and release pancreatic polypeptide, which plays a role in regulating digestive enzyme secretion and gastrointestinal motility.

Dysfunction of the Islets of Langerhans can lead to various endocrine disorders, such as diabetes mellitus, where insulin-producing beta cells are damaged or destroyed, leading to impaired blood sugar regulation.

Blood glucose, also known as blood sugar, is the concentration of glucose in the blood. Glucose is a simple sugar that serves as the main source of energy for the body's cells. It is carried to each cell through the bloodstream and is absorbed into the cells with the help of insulin, a hormone produced by the pancreas.

The normal range for blood glucose levels in humans is typically between 70 and 130 milligrams per deciliter (mg/dL) when fasting, and less than 180 mg/dL after meals. Levels that are consistently higher than this may indicate diabetes or other metabolic disorders.

Blood glucose levels can be measured through a variety of methods, including fingerstick blood tests, continuous glucose monitoring systems, and laboratory tests. Regular monitoring of blood glucose levels is important for people with diabetes to help manage their condition and prevent complications.

Glycosuria is a medical term that refers to the presence of glucose in the urine. Under normal circumstances, the kidneys are able to reabsorb all of the filtered glucose back into the bloodstream. However, when the blood glucose levels become excessively high, such as in uncontrolled diabetes mellitus, the kidneys may not be able to reabsorb all of the glucose, and some of it will spill over into the urine.

Glycosuria can also occur in other conditions that affect glucose metabolism or renal function, such as impaired kidney function, certain medications, pregnancy, and rare genetic disorders. It is important to note that glycosuria alone does not necessarily indicate diabetes, but it may be a sign of an underlying medical condition that requires further evaluation by a healthcare professional.

Streptozocin is an antibiotic and antineoplastic agent, which is primarily used in the treatment of metastatic pancreatic islet cell carcinoma (a type of pancreatic cancer). It is a naturally occurring compound produced by the bacterium Streptomyces achromogenes.

Medically, streptozocin is classified as an alkylating agent due to its ability to interact with DNA and RNA, disrupting the growth and multiplication of malignant cells. However, it can also have adverse effects on non-cancerous cells, particularly in the kidneys and pancreas, leading to potential side effects such as nephrotoxicity (kidney damage) and hyperglycemia (high blood sugar).

It is essential that streptozocin be administered under the supervision of a healthcare professional, who can monitor its effectiveness and potential side effects. The drug is typically given through intravenous infusion, with the dosage and duration tailored to individual patient needs and treatment responses.

... , sometimes referred to as alloxan hydrate, is the name of the organic compound with the formula OC(N(H)CO)2C(OH)2. It ... The name "Alloxan" emerged from an amalgamation of the words "allantoin" and "Oxalsäure" (oxalic acid). The alloxan model of ... Studies suggests that alloxan does not cause diabetes in humans. Others found a significant difference in alloxan plasma levels ... A dimeric derivative alloxantin can be prepared by partial reduction of alloxan with hydrogen sulfide. Alloxan is a toxic ...
in alloxan-induced diabetic mice". World Journal of Pharmacy and Pharmaceutical Sciences. 4: 1571-1586 - via Research Gate.{{ ...
Bertoni) on alloxan-induced diabetic rats". J Pharm Bioallied Sci. 3 (2): 242-8. doi:10.4103/0975-7406.80779. PMC 3103919. PMID ...
Bertoni) on alloxan-induced diabetic rats". Journal of Pharmacy and Bioallied Sciences. 3 (2): 242-248. doi:10.4103/0975- ...
Fruit powder in alloxan-diabetic rats". Journal of Ethnopharmacology. 67 (1): 103-109. doi:10.1016/S0378-8741(99)00004-5. PMID ...
Fruit in alloxan-induced diabetic Rats". South African Journal of Botany. 88: 56-61. doi:10.1016/j.sajb.2013.04.010. ...
Bertoni) on alloxan-induced diabetic rats". J Pharm Bioallied Sci. 3 (2): 242-248. doi:10.4103/0975-7406.80779. PMC 3103919. ...
with Glyburide in Alloxan Induced Diabetic Mice". Evidence-Based Complementary and Alternative Medicine. 5 (2): 159-164. doi: ... and reduced the mortality of alloxan induced diabetic mice by approximately 50%. It showed a synergistic effect with the ...
Steiner, Donald F.; Rauda, Vija; Williams, Robert H. (1961). "Severe Ketoacidosis in the Alloxan Diabetic Rat". Endocrinology. ...
Alloxan Brentjens R, Saltz L (June 2001). "Islet cell tumors of the pancreas: the medical oncologist's perspective". The ... Szkudelski T (2001). "The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas". Physiological ... "Comparison of metabolic abnormalities in diabetes mellitus induced by streptozotocin or by alloxan". Lancet. 1 (7544): 670-671 ...
Menten, ML.; Janouch, M. (1946). "Changes in alkaline phosphatase of kidney following renal damage with alloxan". Proceedings ...
It may also be prepared by digesting alloxan with alcoholic ammonia. Justus von Liebig and Friedrich Wöhler in Giessen, Germany ...
It can also be produced by condensation of alloxan with hydroxylamine. as typical for forming the oxime of other carbonyl ...
"Hypoglycemic Effects ofAnnona stenophyllaandMorus albaPlant Extracts in Alloxan-induced Diabetic Mice". Journal of Biologically ...
On blood glucose levels in normal and alloxan-induced diabetic rats". Journal of Ethnopharmacology. 50 (1): 13-7. doi:10.1016/ ... fed hyperglycemic and alloxan-treated rabbits and rats. Davana oil is used in making perfumes of sweet and fruity fragrances. ...
Streptozotocin or alloxan may be administered to induce chronic diabetes in hamsters. Atherosclerosis may be studied with ...
He completed his MD with a thesis on diabetes caused by alloxan. After graduating from the University of Zurich, Renold was ...
Strecker, A (1862). "Notiz über eine eigenthümliche Oxydation durch Alloxan" [Notice of a curious oxidation by alloxan]. ... The original observation by Strecker involved the use of alloxan as the oxidant in the first step, followed by hydrolysis: The ...
"Antidiabetic effect of a black mangrove species Aegiceras corniculatum in alloxan-induced diabetic rats". J. Adv. Pharm. ...
"Importance of glucagon in the control of futile cycling as studied in alloxan-diabetic dogs". Diabetologia. 30 (3): 175-182. ... reduction in pancreatic glucagon with normalization of somatostatin and decrease in insulin in normoglycemic alloxan-diabetic ...
"Antihyperglycemic and Antihyperlipidemic Effects of Aqueous Extracts of Lannea edulis in Alloxan-Induced Diabetic Rats". ...
Bartosíková, L (2007). "Examination of the antioxidative and antidiabetic effect of pomiferin in alloxan-induced diabetes ...
"Absence of antidiabetic and hypolipidemic effect of Gymnema sylvestre in non-diabetic and alloxan-diabetic rats". Braz. Arch. ...
Although pyrimidine derivatives such as alloxan were known in the early 19th century, a laboratory synthesis of a pyrimidine ... Grimaux, E. (1879). "Synthèse des dérivés uriques de la série de l'alloxane" [Synthesis of urea derivatives of the alloxan ... and alloxan. It is also found in many synthetic compounds such as barbiturates and the HIV drug zidovudine. ...
... is a nitrogenous acid related to barbituric acid that yields alloxan and uramil upon hydrolysis. It is noteworthy ...
Brömme, H. J.; Mörke, W.; Peschke, E. (November 2002). "Transformation of barbituric acid into alloxan by hydroxyl radicals: ... free radical substitution Conversion of benzene into phenol by using Fenton's reagent Oxidation of barbituric acid into alloxan ...
"Antihyperglycemic and hypolipidemic effects of Helicteres isora roots in alloxan-induced diabetic rats: a possible mechanism of ...
... a study in alloxan-induced diabetic rats". Cell Biochemistry and Function. 26 (8): 859-865. doi:10.1002/cbf.1517. ISSN 1099- ...
... molybdate of ammonia and alloxan. In 1843, with mineralogist Johann Reinhard Blum, he proposed the name "leonhardite" for ...
Biochemical Physiology 121 (4): 323 - 332, (1998) Alloxan - Induced cataract and leakage of lens crystallins in the serum of ...
Alloxan, sometimes referred to as alloxan hydrate, is the name of the organic compound with the formula OC(N(H)CO)2C(OH)2. It ... The name "Alloxan" emerged from an amalgamation of the words "allantoin" and "Oxalsäure" (oxalic acid). The alloxan model of ... Studies suggests that alloxan does not cause diabetes in humans. Others found a significant difference in alloxan plasma levels ... A dimeric derivative alloxantin can be prepared by partial reduction of alloxan with hydrogen sulfide. Alloxan is a toxic ...
alloxan diabetes. experimental diabetes mellitus produced in animals by the administration of alloxan, which damages the ...
... -INDUCED DIABETIC WISTAR R... ... effect of caffeine on blood glucose and lipid profile in alloxan- - ... A Research proposal for effect of caffeine on blood glucose and lipid profile in alloxan-induced diabetic wistar rats:. Reviews ... EFFECT OF CAFFEINE ON BLOOD GLUCOSE AND LIPID PROFILE IN ALLOXAN-INDUCED DIABETIC WISTAR RATS. Download Complete Material ...
Wistar rats were used and divided into six groups: sedentary alloxan (SA), sedentary control (SC), continuous trained alloxan ( ... CA), intermittent trained alloxan (IA), continuous trained control (CC) and intermittent trained control (IC). Alloxan (250 mg/ ... At 28 days, the alloxan animals displayed higher glycemia after glucose overload than the control animals. No differences in ... Compared to the other groups, DNA concentrations were higher in the alloxan animals that were subjected to continuous training ...
Thus, this study is aimed at determining quail eggs dietary effect on the blood sugar and lipid profile of alloxan induced ... EFFECTS OF QUAIL (COTURNIX JAPONICA)EGGDIET ON BLOOD SUGAR AND LIPID PROFILELEVELS OF ALLOXAN INDUCED DIABETIC ALBINO RATS. ... Sixty (60) processed quail eggs and shells, using the cooked-dry method, were administered to thirty six (36) alloxan induced ... EVALUATION OF THE ANTIDIABETIC EFFECTS OF WATER AND METHANOLIC EXTRACTS OF AVOCADO (PERSEA AMERICANA) SEED ON ALLOXAN INDUCED ...
... , Journal of Diabetes and its ... Duration-dependent changes in calcium responsiveness in the alloxan-diabetic rat intestine. ...
... against alloxan induced hyperglycemia in albino rats of Wister strain. Upon alloxan (150mg/kg body weight) induction, the ... The results suggest that the strawberry extract has effective hypoglycemic activity against alloxan diabetes. The poly phenolic ...
Histopathological studies of alloxan induced diabetic rats of the active fraction of Stereospermum tetragonum DC. ... Histopathological studies of alloxan induced diabetic rats of the active fraction of Stereospermum tetragonum DC. ... Kingsley, Bino, Saminathan, Marylin, Aravinth, Pemaiah Brindha, Appian Subramoniam (2013) Histopathological studies of alloxan ...
reduces blood glucose in normal and alloxan diabetic rabbits.," BMC Complementary and Alternative Medicine, vol. 3, no. 1, p. 4 ... S. Ghosh and S. A. Suryawanshi, "Effect of Vinca rosea extracts in treatment of alloxan diabetes in male albino rats," Indian ...
Bassler, K.H.; Dreiss, G. Antiketogenic effect of xylitol in alloxan-diabetic rats. Klin. Wochenschr. 1963, 41, 593-595. [ ...
Antidiabetic effect of Equisetum giganteum L. extract on alloxan-diabetic rabbit. J Ethnopharmacol. 2020;260:112898. View ...
Globularia alypum Extracts Attenuate Hyperglycemia and Protect against Various Organ Toxicities in Alloxan-Induced Experimental ...
2024 Royal College of Physicians of Edinburgh, 9 Queen Street, Edinburgh EH2 ...
The activity of the extracted enzyme is partially inhibited upon incubation with the diabetogenic drugs alloxan, streptozotocin ...
Saba, A.B., Oyagbemi, A.A. and Azeez, O.I. (2010) Antidiabetic and Haematinic Effects of Parquetina nigrescens on Alloxan ... Szkudelski, T. (2001) The Mechanism of Alloxan and Streptozotocin Action in β-Cells of the Rat Pancreas. Physiological Research ... and Some Haematological Effects of Ethylacetate and N-Butanol Fractions of Ganoderma lucidum Aqueous Extract in Alloxan-Induced ...
This was concluded after a study was performed on rats, giving them a certain amount of alloxan each day which mimicked the ... It used alloxan-induced rat models to study the anti-diabetes properties of the plant. ... Rats were inoculated with alloxan which mimics the effects of diabetes and then were treated with ethanol extracts containing ... it showed that it was much less damaged than those who were not exposed to the alloxan. ...
fruit peels on alloxan induced diabetic rats. / Mishra MK, Barik BB. / Indian DrugsIndian Drugs [Internet]. 2009;46(10):66 - 69 ... Anti-Diabetic / Fruit and Peels: Study evaluated various extracts of peels for hypoglycemic activity in alloxan induced ... hispida for hypoglycemic effect in alloxan-induced diabetic rabbits. The results showed significant dose-dependent reduction in ...
The efficacy studies were carried out in Alloxan induced Diabetic Wistar rats. The study revealed that Trigomoaza was effective ...
Indeed, in the alloxan model of diabetes, PUFAs increase the diabetogenic effect of alloxan and saturated fat protects.. I ... The alloxan diabetes issue is an aside. I assume you are talking about the Rodriguez paper (http://www.ncbi.nlm.nih.gov/pubmed/ ...
Action of Capparis deciduas against alloxan-induced oxidative stress and diabetic in rat tissues. Pharmacol. Res., 36: 221-228. ... Combined vitamins (C and E) and insulin improve oxidative stress and pancreatic and hepatic injury in alloxan diabetic rats. ...
Effect of shilajit on blood glucose and lipid profile in alloxan-induced diabetic rats. Indian Journal of Pharmacology. 2004: ...
Antidiabetic Activity of Durian (Durio Zibethinus Murr.) and Rambutan (Nephelium Lappaceum L.) Fruit Peels in Alloxan Diabetic ...
alone and in combination with a lipid lowering agent (fenofibrate) in alloxan-induced diabetic rats. Diabetes was induced in ... Potentiates the Hypolipidemic and Hepatoprotective Activity of Fenofibrate in Alloxan-Induced Diabetic Rats ... male Wister albino rats by the administration of single intra-peritoneal injection of alloxan monohydrate (120 mg/kg b.w.). Two ... that of monotherapy in controlling diabetes mellitus associated with cardiovascular diseases and hepatic dysfunction in alloxan ...
reduces blood glucose in normal and alloxan diabetic rabbits The leaf juice or water decoction of Catharanthus roseus L. ( ...
26) Study of aqueous extracts of A. cepa showed significant dose dependent hypoglycemic and hypolipidemic effects in alloxan ... Anti-diabetic effects of Allium cepa (onions) aqueous extracts on alloxan-induced diabetic Rattus novergicus / Ozougwu, Jevas C ...
Alloxan Hydrate. ₹100.00. Select options. * Acidum Picricum. ₹100.00. Select options. Ferrum Metallicum Ferrum Picricum ...
... of the antioxidant efficacy of Terpenes isolated from the Zingiber officinale Roscoe in treating experimentally alloxan-induced ...
Evaluation of Antihyperglycemic Effect of Extract of Moringa stenopetala (Baker f.) Aqueous Leaves on Alloxan-Induced Diabetic ...
Stem from Indonesia in Wistar Rat Induced by Alloxan ...
... and insulin in alloxan-diabetic Wistar male rats were compared with those in healthy and untreated diabetic controls after a ... ALLOXAN; ZINC-OXIDE NANOPARTICLES; SILVER NANOPARTICLES; GREEN SYNTHESIS; LEAF EXTRACT; ANTIBACTERIAL ACTIVITY; SILYMARIN; ... INSULIN; ANTIOXIDANT; MECHANISM; ALLOXAN; Bio-metal interface; Hyperglycemia; Hyperlipidemia; Silymarin; Type 1 diabetes. ISSN ...
  • Thus, this study is aimed at determining quail egg's dietary effect on the blood sugar and lipid profile of alloxan induced diabetic rats. (schoolprojecttopics.com)
  • Sixty (60) processed quail eggs and shells, using the cooked-dry method, were administered to thirty six (36) alloxan induced diabetic rats which were grouped into nine (9) different groups of four (4) rats each, at varied doses per group for a duration of seven (7), fourteen (14) and twenty one (21) days. (schoolprojecttopics.com)
  • Histopathological studies of alloxan induced diabetic rats of the active fraction of Stereospermum tetragonum DC. (rug.nl)
  • Globularia alypum Extracts Attenuate Hyperglycemia and Protect against Various Organ Toxicities in Alloxan-Induced Experimental Diabetic Rats. (nih.gov)
  • alone and in combination with a lipid lowering agent (fenofibrate) in alloxan-induced diabetic rats. (sciencepublishinggroup.com)
  • The current study demonstrates that combination therapy of EEAR and fenofibrate was more effective than that of monotherapy in controlling diabetes mellitus associated with cardiovascular diseases and hepatic dysfunction in alloxan-induced diabetic rats. (sciencepublishinggroup.com)
  • Aqueous Leaves on Alloxan-Induced Diabetic Rats. (bvsalud.org)
  • This study aimed to examine the effects of intermittent and continuous swimming training on muscle protein metabolism in neonatal alloxan-administered rats. (biomedcentral.com)
  • Wistar rats were used and divided into six groups: sedentary alloxan (SA), sedentary control (SC), continuous trained alloxan (CA), intermittent trained alloxan (IA), continuous trained control (CC) and intermittent trained control (IC). (biomedcentral.com)
  • Alloxan (250 mg/kg body weight) was injected into newborn rats at 6 days of age. (biomedcentral.com)
  • The present research study was designed to analyze the effect of strawberry fruit extracts (water and methanol) against alloxan induced hyperglycemia in albino rats of Wister strain. (jatstech.org)
  • The efficacy studies were carried out in Alloxan induced Diabetic Wistar rats. (hum-molgen.org)
  • Diabetes was induced in male Wister albino rats by the administration of single intra-peritoneal injection of alloxan monohydrate (120 mg/kg b.w. (sciencepublishinggroup.com)
  • The alloxan model of diabetes was first described in rabbits by Dunn, Sheehan and McLetchie in 1943. (wikipedia.org)
  • This causes an insulin-dependent diabetes mellitus (called "alloxan diabetes") in these animals, with characteristics similar to type 1 diabetes in humans. (wikipedia.org)
  • Studies suggests that alloxan does not cause diabetes in humans. (wikipedia.org)
  • Others found a significant difference in alloxan plasma levels in children with and without diabetes Type 1. (wikipedia.org)
  • Because it selectively kills the insulin-producing beta-cells found in the pancreas, alloxan is used to induce diabetes in laboratory animals. (wikipedia.org)
  • The results suggest that the strawberry extract has effective hypoglycemic activity against alloxan diabetes. (jatstech.org)
  • The beta cell toxic action of alloxan is initiated by free radicals formed in this redox reaction. (wikipedia.org)
  • Alloxan is a toxic glucose analogue, which selectively destroys insulin-producing cells in the pancreas (that is, beta cells) when administered to rodents and many other animal species. (wikipedia.org)
  • Alloxan is selectively toxic to insulin-producing pancreatic beta cells because it preferentially accumulates in beta cells through uptake via the GLUT2 glucose transporter. (wikipedia.org)
  • Furthermore, alloxan inhibits glucokinase, a SH-containing protein essential for insulin secretion induced by glucose. (wikipedia.org)
  • Most studies have shown that alloxan is not toxic to the human beta-cell, even in very high doses, probably because of differing glucose uptake mechanisms in humans and rodents. (wikipedia.org)
  • At 28 days, the alloxan animals displayed higher glycemia after glucose overload than the control animals. (biomedcentral.com)
  • Upon alloxan (150mg/kg body weight) induction, the diabetic animals showed marked increase in the values of plasma glucose, urea, uric acid, creatinine and concomitant decrease in body weight and plasma insulin level. (jatstech.org)
  • Compared to the other groups, DNA concentrations were higher in the alloxan animals that were subjected to continuous training, whereas the DNA/protein ratio was higher in the alloxan animals that were subjected to intermittent training. (biomedcentral.com)
  • It was concluded that continuous and intermittent training sessions were effective in altering muscle growth by hyperplasia and hypertrophy, respectively, in alloxan-administered animals. (biomedcentral.com)
  • In addition, alloxan has a high affinity to SH-containing cellular compounds and, as a result, reduces glutathione content. (wikipedia.org)
  • Wagenitz in alloxan induced diabetic mice / Análise fitoquímica e potencial hipoglicemiante de Filago hurdwarica (Wall. (bvsalud.org)
  • Hydromethanolic plant extract and fractions of F. hurdwarica were screened for antidiabetic activity and given to the alloxan -induced diabetic mice at a concentration of 150-250 mg/kg of body weight in different groups of 6 diabetic mice each orally once a day for 15 days. (bvsalud.org)
  • 13. Antidiabetic and antioxidant potential of ethanolic extract of Butea monosperma leaves in alloxan-induced diabetic mice. (nih.gov)
  • 4. Evaluation of the effect of piperine per se on blood glucose level in alloxan-induced diabetic mice. (nih.gov)
  • An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to Alloxan monohydrate (3237-50-1). (nih.gov)
  • Genetic Toxicity Evaluation of Alloxan Monohydrate in Salmonella/E.coli Mutagenicity Test or Ames Test. (nih.gov)
  • Following the time of acclimatization, the animals had an overnight fast of 18 hours before being prepped for alloxan monohydrate-induced diabetes. (ijmhr.org)
  • In this study, we evaluated the antidiabetic effects of these extracts using an alloxan-induced diabetic animal model. (jptcp.com)
  • Group 3: Alloxan-induced and aqueous extract-treated animals and Group 4 was only given a 40 g/L dose of the aqueous extract of avocado. (ijmhr.org)
  • [ 10 ] Without exerting intrinsic effects on survival, [ 10 ] alloxan limits endogenous insulin release and thus minimizes interindividual differences in insulin levels upon glucose load. (medscape.com)
  • This study suggests that thioltransferase (glutaredoxin) plays a significant role in the cytotoxicity of alloxan in vulnerable tissues. (nih.gov)
  • Afterward, the animals had free access to regular rabbit chow and drinking water enriched with glucose to face alloxan-induced acute hypoglycemia. (medscape.com)
  • In our animal model, critical illness was induced by the combination of placing intravascular catheters, selectively destroying pancreatic β-cells by alloxan, followed by burn injury, which has previously shown to reveal the dynamic endocrine and metabolic changes characteristic of critical illness, including hyperglycemia and endogenous insulin deficiency. (medscape.com)
  • Swiss Albino mice were made diabetic by a single dose of alloxan (150 mg/kg). (bvsalud.org)