Transplantation between individuals of the same species. Usually refers to genetically disparate individuals in contradistinction to isogeneic transplantation for genetically identical individuals.
An immune response with both cellular and humoral components, directed against an allogeneic transplant, whose tissue antigens are not compatible with those of the recipient.
Tissues, cells, or organs transplanted between genetically different individuals of the same species.
The transference of a heart from one human or animal to another.
The survival of a graft in a host, the factors responsible for the survival and the changes occurring within the graft during growth in the host.
The grafting of skin in humans or animals from one site to another to replace a lost portion of the body surface skin.
The transference of a kidney from one human or animal to another.
Transplantation of tissue typical of one area to a different recipient site. The tissue may be autologous, heterologous, or homologous.
Partial or total replacement of the CORNEA from one human or animal to another.
The grafting of bone from a donor site to a recipient site.
An induced state of non-reactivity to grafted tissue from a donor organism that would ordinarily trigger a cell-mediated or humoral immune response.
A general term for the complex phenomena involved in allo- and xenograft rejection by a host and graft vs host reaction. Although the reactions involved in transplantation immunology are primarily thymus-dependent phenomena of cellular immunity, humoral factors also play a part in late rejection.
Centers for acquiring, characterizing, and storing bones or bone tissue for future use.
Transplantation between genetically identical individuals, i.e., members of the same species with identical histocompatibility antigens, such as monozygotic twins, members of the same inbred strain, or members of a hybrid population produced by crossing certain inbred strains.
The induction of prolonged survival and growth of allografts of either tumors or normal tissues which would ordinarily be rejected. It may be induced passively by introducing graft-specific antibodies from previously immunized donors, which bind to the graft's surface antigens, masking them from recognition by T-cells; or actively by prior immunization of the recipient with graft antigens which evoke specific antibodies and form antigen-antibody complexes which bind to the antigen receptor sites of the T-cells and block their cytotoxic activity.
Antibodies from an individual that react with ISOANTIGENS of another individual of the same species.
Individuals supplying living tissue, organs, cells, blood or blood components for transfer or transplantation to histocompatible recipients.
Antigens that exist in alternative (allelic) forms in a single species. When an isoantigen is encountered by species members who lack it, an immune response is induced. Typical isoantigens are the BLOOD GROUP ANTIGENS.
The transference of pancreatic islets within an individual, between individuals of the same species, or between individuals of different species.
The process by which a tissue or aggregate of cells is kept alive outside of the organism from which it was derived (i.e., kept from decay by means of a chemical agent, cooling, or a fluid substitute that mimics the natural state within the organism).
Deliberate prevention or diminution of the host's immune response. It may be nonspecific as in the administration of immunosuppressive agents (drugs or radiation) or by lymphocyte depletion or may be specific as in desensitization or the simultaneous administration of antigen and immunosuppressive drugs.
Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.
The transference of a part of or an entire liver from one human or animal to another.
The transference of either one or both of the lungs from one human or animal to another.
The specific failure of a normally responsive individual to make an immune response to a known antigen. It results from previous contact with the antigen by an immunologically immature individual (fetus or neonate) or by an adult exposed to extreme high-dose or low-dose antigen, or by exposure to radiation, antimetabolites, antilymphocytic serum, etc.
Inflammation of the BRONCHIOLES leading to an obstructive lung disease. Bronchioles are characterized by fibrous granulation tissue with bronchial exudates in the lumens. Clinical features include a nonproductive cough and DYSPNEA.
Preservation of cells, tissues, organs, or embryos by freezing. In histological preparations, cryopreservation or cryofixation is used to maintain the existing form, structure, and chemical composition of all the constituent elements of the specimens.
Organs, tissues, or cells taken from the body for grafting into another area of the same body or into another individual.
The process by which organs are kept viable outside of the organism from which they were removed (i.e., kept from decay by means of a chemical agent, cooling, or a fluid substitute that mimics the natural state within the organism).
The degree of antigenic similarity between the tissues of different individuals, which determines the acceptance or rejection of allografts.
Elements of limited time intervals, contributing to particular results or situations.
Measure of histocompatibility at the HL-A locus. Peripheral blood lymphocytes from two individuals are mixed together in tissue culture for several days. Lymphocytes from incompatible individuals will stimulate each other to proliferate significantly (measured by tritiated thymidine uptake) whereas those from compatible individuals will not. In the one-way MLC test, the lymphocytes from one of the individuals are inactivated (usually by treatment with MITOMYCIN or radiation) thereby allowing only the untreated remaining population of cells to proliferate in response to foreign histocompatibility antigens.
The large fragment formed when COMPLEMENT C4 is cleaved by COMPLEMENT C1S. The membrane-bound C4b binds COMPLEMENT C2A, a SERINE PROTEASE, to form C4b2a (CLASSICAL PATHWAY C3 CONVERTASE) and subsequent C4b2a3b (CLASSICAL PATHWAY C5 CONVERTASE).
Identification of the major histocompatibility antigens of transplant DONORS and potential recipients, usually by serological tests. Donor and recipient pairs should be of identical ABO blood group, and in addition should be matched as closely as possible for HISTOCOMPATIBILITY ANTIGENS in order to minimize the likelihood of allograft rejection. (King, Dictionary of Genetics, 4th ed)
Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.
An organism that, as a result of transplantation of donor tissue or cells, consists of two or more cell lines descended from at least two zygotes. This state may result in the induction of donor-specific TRANSPLANTATION TOLERANCE.
A dead body, usually a human body.
The destroying of all forms of life, especially microorganisms, by heat, chemical, or other means.
A cyclic undecapeptide from an extract of soil fungi. It is a powerful immunosupressant with a specific action on T-lymphocytes. It is used for the prophylaxis of graft rejection in organ and tissue transplantation. (From Martindale, The Extra Pharmacopoeia, 30th ed).
A group of antigens that includes both the major and minor histocompatibility antigens. The former are genetically determined by the major histocompatibility complex. They determine tissue type for transplantation and cause allograft rejections. The latter are systems of allelic alloantigens that can cause weak transplant rejection.
A group of closely related cyclic undecapeptides from the fungi Trichoderma polysporum and Cylindocarpon lucidum. They have some antineoplastic and antifungal action and significant immunosuppressive effects. Cyclosporins have been proposed as adjuvants in tissue and organ transplantation to suppress graft rejection.
Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.
Centers for acquiring, characterizing, and storing organs or tissue for future use.
The transference of a pancreas from one human or animal to another.
The genetic region which contains the loci of genes which determine the structure of the serologically defined (SD) and lymphocyte-defined (LD) TRANSPLANTATION ANTIGENS, genes which control the structure of the IMMUNE RESPONSE-ASSOCIATED ANTIGENS, HUMAN; the IMMUNE RESPONSE GENES which control the ability of an animal to respond immunologically to antigenic stimuli, and genes which determine the structure and/or level of the first four components of complement.
Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.
The transference of BONE MARROW from one human or animal to another for a variety of purposes including HEMATOPOIETIC STEM CELL TRANSPLANTATION or MESENCHYMAL STEM CELL TRANSPLANTATION.
A repeat operation for the same condition in the same patient due to disease progression or recurrence, or as followup to failed previous surgery.
Genetically developed small pigs for use in biomedical research. There are several strains - Yucatan miniature, Sinclair miniature, and Minnesota miniature.
An encapsulated lymphatic organ through which venous blood filters.
A membrane glycoprotein and differentiation antigen expressed on the surface of T-cells that binds to CD40 ANTIGENS on B-LYMPHOCYTES and induces their proliferation. Mutation of the gene for CD40 ligand is a cause of HYPER-IGM IMMUNODEFICIENCY SYNDROME, TYPE 1.
Procedures used to reconstruct, restore, or improve defective, damaged, or missing structures.
A state of prolonged irreversible cessation of all brain activity, including lower brain stem function with the complete absence of voluntary movements, responses to stimuli, brain stem reflexes, and spontaneous respirations. Reversible conditions which mimic this clinical state (e.g., sedative overdose, hypothermia, etc.) are excluded prior to making the determination of brain death. (From Adams et al., Principles of Neurology, 6th ed, pp348-9)
Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.
Serum containing GAMMA-GLOBULINS which are antibodies for lymphocyte ANTIGENS. It is used both as a test for HISTOCOMPATIBILITY and therapeutically in TRANSPLANTATION.
Combinations of diagnostic or therapeutic substances linked with specific immune substances such as IMMUNOGLOBULINS; MONOCLONAL ANTIBODIES; or ANTIGENS. Often the diagnostic or therapeutic substance is a radionuclide. These conjugates are useful tools for specific targeting of DRUGS and RADIOISOTOPES in the CHEMOTHERAPY and RADIOIMMUNOTHERAPY of certain cancers.
The administrative procedures involved with acquiring TISSUES or organs for TRANSPLANTATION through various programs, systems, or organizations. These procedures include obtaining consent from TISSUE DONORS and arranging for transportation of donated tissues and organs, after TISSUE HARVESTING, to HOSPITALS for processing and transplantation.
A critical subpopulation of regulatory T-lymphocytes involved in MHC Class I-restricted interactions. They include both cytotoxic T-lymphocytes (T-LYMPHOCYTES, CYTOTOXIC) and CD8+ suppressor T-lymphocytes.
Disease having a short and relatively severe course.
An increased reactivity to specific antigens mediated not by antibodies but by cells.
Immunosuppression by reduction of circulating lymphocytes or by T-cell depletion of bone marrow. The former may be accomplished in vivo by thoracic duct drainage or administration of antilymphocyte serum. The latter is performed ex vivo on bone marrow before its transplantation.
Transplant comprised of an individual's own tissue, transferred from one part of the body to another.
Transference of tissue within an individual, between individuals of the same species, or between individuals of different species.
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations, or by parent x offspring matings carried out with certain restrictions. All animals within an inbred strain trace back to a common ancestor in the twentieth generation.
CD4-positive T cells that inhibit immunopathology or autoimmune disease in vivo. They inhibit the immune response by influencing the activity of other cell types. Regulatory T-cells include naturally occurring CD4+CD25+ cells, IL-10 secreting Tr1 cells, and Th3 cells.
The longest and largest bone of the skeleton, it is situated between the hip and the knee.
Large, transmembrane, non-covalently linked glycoproteins (alpha and beta). Both chains can be polymorphic although there is more structural variation in the beta chains. The class II antigens in humans are called HLA-D ANTIGENS and are coded by a gene on chromosome 6. In mice, two genes named IA and IE on chromosome 17 code for the H-2 antigens. The antigens are found on B-lymphocytes, macrophages, epidermal cells, and sperm and are thought to mediate the competence of and cellular cooperation in the immune response. The term IA antigens used to refer only to the proteins encoded by the IA genes in the mouse, but is now used as a generic term for any class II histocompatibility antigen.
General dysfunction of an organ occurring immediately following its transplantation. The term most frequently refers to renal dysfunction following KIDNEY TRANSPLANTATION.
The immune responses of a host to a graft. A specific response is GRAFT REJECTION.
Form of passive immunization where previously sensitized immunologic agents (cells or serum) are transferred to non-immune recipients. When transfer of cells is used as a therapy for the treatment of neoplasms, it is called adoptive immunotherapy (IMMUNOTHERAPY, ADOPTIVE).
Transference of an organ between individuals of the same species or between individuals of different species.
Transference of a tissue or organ from either an alive or deceased donor, within an individual, between individuals of the same species, or between individuals of different species.
The occurrence in an individual of two or more cell populations of different chromosomal constitutions, derived from different individuals. This contrasts with MOSAICISM in which the different cell populations are derived from a single individual.
Antibodies produced by a single clone of cells.
A critical subpopulation of T-lymphocytes involved in the induction of most immunological functions. The HIV virus has selective tropism for the T4 cell which expresses the CD4 phenotypic marker, a receptor for HIV. In fact, the key element in the profound immunosuppression seen in HIV infection is the depletion of this subset of T-lymphocytes.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Transplantation of an individual's own tissue from one site to another site.
The chilling of a tissue or organ during decreased BLOOD perfusion or in the absence of blood supply. Cold ischemia time during ORGAN TRANSPLANTATION begins when the organ is cooled with a cold perfusion solution after ORGAN PROCUREMENT surgery, and ends after the tissue reaches physiological temperature during implantation procedures.
The transparent anterior portion of the fibrous coat of the eye consisting of five layers: stratified squamous CORNEAL EPITHELIUM; BOWMAN MEMBRANE; CORNEAL STROMA; DESCEMET MEMBRANE; and mesenchymal CORNEAL ENDOTHELIUM. It serves as the first refracting medium of the eye. It is structurally continuous with the SCLERA, avascular, receiving its nourishment by permeation through spaces between the lamellae, and is innervated by the ophthalmic division of the TRIGEMINAL NERVE via the ciliary nerves and those of the surrounding conjunctiva which together form plexuses. (Cline et al., Dictionary of Visual Science, 4th ed)
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
Non-human animals, selected because of specific characteristics, for use in experimental research, teaching, or testing.
Partial or total replacement of all layers of a central portion of the cornea.
Single layer of large flattened cells covering the surface of the cornea.
The transfer of lymphocytes from a donor to a recipient or reinfusion to the donor.
The transference between individuals of the entire face or major facial structures. In addition to the skin and cartilaginous tissue (CARTILAGE), it may include muscle and bone as well.
The major interferon produced by mitogenically or antigenically stimulated LYMPHOCYTES. It is structurally different from TYPE I INTERFERON and its major activity is immunoregulation. It has been implicated in the expression of CLASS II HISTOCOMPATIBILITY ANTIGENS in cells that do not normally produce them, leading to AUTOIMMUNE DISEASES.
The hemispheric articular surface at the upper extremity of the thigh bone. (Stedman, 26th ed)
A graft consisting of multiple tissues, such as muscle, bone, nerve, vasculature, and skin, comprising a functional unit for reconstructive purposes.
An organism whose body contains cell populations of different genotypes as a result of the TRANSPLANTATION of donor cells after sufficient ionizing radiation to destroy the mature recipient's cells which would otherwise reject the donor cells.
Morphologic alteration of small B LYMPHOCYTES or T LYMPHOCYTES in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by INTERLEUKINS; MITOGENS such as PHYTOHEMAGGLUTININS, and by specific ANTIGENS. It may also occur in vivo as in GRAFT REJECTION.
A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation in vitro.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
Infections resulting from the implantation of prosthetic devices. The infections may be acquired from intraoperative contamination (early) or hematogenously acquired from other sites (late).
The span of viability of a tissue or an organ.
A trisaccharide occurring in Australian manna (from Eucalyptus spp, Myrtaceae) and in cottonseed meal.
Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other injury.
The transference of a complete HAND, as a composite of many tissue types, from one individual to another.
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding.
The procedure established to evaluate the health status and risk factors of the potential DONORS of biological materials. Donors are selected based on the principles that their health will not be compromised in the process, and the donated materials, such as TISSUES or organs, are safe for reuse in the recipients.
Solutions used to store organs and minimize tissue damage, particularly while awaiting implantation.
Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.
An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
Membrane glycoproteins consisting of an alpha subunit and a BETA 2-MICROGLOBULIN beta subunit. In humans, highly polymorphic genes on CHROMOSOME 6 encode the alpha subunits of class I antigens and play an important role in determining the serological specificity of the surface antigen. Class I antigens are found on most nucleated cells and are generally detected by their reactivity with alloantisera. These antigens are recognized during GRAFT REJECTION and restrict cell-mediated lysis of virus-infected cells.
Long convoluted tubules in the nephrons. They collect filtrate from blood passing through the KIDNEY GLOMERULUS and process this filtrate into URINE. Each renal tubule consists of a BOWMAN CAPSULE; PROXIMAL KIDNEY TUBULE; LOOP OF HENLE; DISTAL KIDNEY TUBULE; and KIDNEY COLLECTING DUCT leading to the central cavity of the kidney (KIDNEY PELVIS) that connects to the URETER.
The demonstration of the cytotoxic effect on a target cell of a lymphocyte, a mediator released by a sensitized lymphocyte, an antibody, or complement.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Surgical removal of the thymus gland. (Dorland, 28th ed)
An antigenic mismatch between donor and recipient blood. Antibodies present in the recipient's serum may be directed against antigens in the donor product. Such a mismatch may result in a transfusion reaction in which, for example, donor blood is hemolyzed. (From Saunders Dictionary & Encyclopedia of Laboratory Medicine and Technology, 1984).
A 302-amino-acid fragment in the alpha chain (672-1663) of C3b. It is generated when C3b is inactivated (iC3b) and its alpha chain is cleaved by COMPLEMENT FACTOR I into C3c, and C3dg (955-1303) in the presence COMPLEMENT FACTOR H. Serum proteases further degrade C3dg into C3d (1002-1303) and C3g (955-1001).
An INTEFERON-inducible CXC chemokine that is specific for the CXCR3 RECEPTOR.
The procedure of removing TISSUES, organs, or specimens from DONORS for reuse, such as TRANSPLANTATION.
The growth action of bone tissue as it assimilates surgically implanted devices or prostheses to be used as either replacement parts (e.g., hip) or as anchors (e.g., endosseous dental implants).
Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner.
The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.
The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)
Injections into the lymph nodes or the lymphatic system.
The space in the eye, filled with aqueous humor, bounded anteriorly by the cornea and a small portion of the sclera and posteriorly by a small portion of the ciliary body, the iris, and that part of the crystalline lens which presents through the pupil. (Cline et al., Dictionary of Visual Science, 4th ed, p109)
Disorder occurring in the central or peripheral area of the cornea. The usual degree of transparency becomes relatively opaque.
White blood cells formed in the body's lymphoid tissue. The nucleus is round or ovoid with coarse, irregularly clumped chromatin while the cytoplasm is typically pale blue with azurophilic (if any) granules. Most lymphocytes can be classified as either T or B (with subpopulations of each), or NATURAL KILLER CELLS.
Non-cadaveric providers of organs for transplant to related or non-related recipients.
A transmembrane protein belonging to the tumor necrosis factor superfamily that was originally discovered on cells of the lymphoid-myeloid lineage, including activated T-LYMPHOCYTES and NATURAL KILLER CELLS. It plays an important role in immune homeostasis and cell-mediated toxicity by binding to the FAS RECEPTOR and triggering APOPTOSIS.
Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care. (Dictionary of Health Services Management, 2d ed)
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
Manifestations of the immune response which are mediated by antigen-sensitized T-lymphocytes via lymphokines or direct cytotoxicity. This takes place in the absence of circulating antibody or where antibody plays a subordinate role.
Liquids transforming into solids by the removal of heat.
Differentiation antigens residing on mammalian leukocytes. CD stands for cluster of differentiation, which refers to groups of monoclonal antibodies that show similar reactivity with certain subpopulations of antigens of a particular lineage or differentiation stage. The subpopulations of antigens are also known by the same CD designation.
Glycoproteins found on the membrane or surface of cells.
White blood cells. These include granular leukocytes (BASOPHILS; EOSINOPHILS; and NEUTROPHILS) as well as non-granular leukocytes (LYMPHOCYTES and MONOCYTES).
Immunized T-lymphocytes which can directly destroy appropriate target cells. These cytotoxic lymphocytes may be generated in vitro in mixed lymphocyte cultures (MLC), in vivo during a graft-versus-host (GVH) reaction, or after immunization with an allograft, tumor cell or virally transformed or chemically modified target cell. The lytic phenomenon is sometimes referred to as cell-mediated lympholysis (CML). These CD8-positive cells are distinct from NATURAL KILLER CELLS and NATURAL KILLER T-CELLS. There are two effector phenotypes: TC1 and TC2.
Thickening and loss of elasticity of the walls of ARTERIES of all sizes. There are many forms classified by the types of lesions and arteries involved, such as ATHEROSCLEROSIS with fatty lesions in the ARTERIAL INTIMA of medium and large muscular arteries.
The movement of cells from one location to another. Distinguish from CYTOKINESIS which is the process of dividing the CYTOPLASM of a cell.
A subclass of winged helix DNA-binding proteins that share homology with their founding member fork head protein, Drosophila.
Pathological processes involving the URETERS.
The production of ANTIBODIES by proliferating and differentiated B-LYMPHOCYTES under stimulation by ANTIGENS.
A classification of T-lymphocytes, especially into helper/inducer, suppressor/effector, and cytotoxic subsets, based on structurally or functionally different populations of cells.
The major group of transplantation antigens in the mouse.
The aorta from the DIAPHRAGM to the bifurcation into the right and left common iliac arteries.
Allelic alloantigens often responsible for weak graft rejection in cases when (major) histocompatibility has been established by standard tests. In the mouse they are coded by more than 500 genes at up to 30 minor histocompatibility loci. The most well-known minor histocompatibility antigen in mammals is the H-Y antigen.
Death of cells in the KIDNEY CORTEX, a common final result of various renal injuries including HYPOXIA; ISCHEMIA; and drug toxicity.
A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.
Pathological processes of the KIDNEY or its component tissues.
The clinical entity characterized by anorexia, diarrhea, loss of hair, leukopenia, thrombocytopenia, growth retardation, and eventual death brought about by the GRAFT VS HOST REACTION.
Irradiation of the whole body with ionizing or non-ionizing radiation. It is applicable to humans or animals but not to microorganisms.
The second longest bone of the skeleton. It is located on the medial side of the lower leg, articulating with the FIBULA laterally, the TALUS distally, and the FEMUR proximally.
Chelating agent used for heavy metal poisoning and assay. It causes diabetes.
Immunologic techniques based on the use of: (1) enzyme-antibody conjugates; (2) enzyme-antigen conjugates; (3) antienzyme antibody followed by its homologous enzyme; or (4) enzyme-antienzyme complexes. These are used histologically for visualizing or labeling tissue specimens.
One of the protein CROSS-LINKING REAGENTS that is used as a disinfectant for sterilization of heat-sensitive equipment and as a laboratory reagent, especially as a fixative.
Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.
The cartilaginous and membranous tube descending from the larynx and branching into the right and left main bronchi.
Replacement for a hip joint.
A double-walled epithelial capsule that is the bulbous closed proximal end of the kidney tubular system. It surrounds the cluster of convoluted capillaries of KIDNEY GLOMERULUS and is continuous with the convoluted PROXIMAL KIDNEY TUBULE.
Antigens determined by leukocyte loci found on chromosome 6, the major histocompatibility loci in humans. They are polypeptides or glycoproteins found on most nucleated cells and platelets, determine tissue types for transplantation, and are associated with certain diseases.
An immunological attack mounted by a graft against the host because of tissue incompatibility when immunologically competent cells are transplanted to an immunologically incompetent host; the resulting clinical picture is that of GRAFT VS HOST DISEASE.
The main trunk of the systemic arteries.
An inhibitory T CELL receptor that is closely related to CD28 ANTIGEN. It has specificity for CD80 ANTIGEN and CD86 ANTIGEN and acts as a negative regulator of peripheral T cell function. CTLA-4 antigen is believed to play role in inducing PERIPHERAL TOLERANCE.
An alternative to amputation in patients with neoplasms, ischemia, fractures, and other limb-threatening conditions. Generally, sophisticated surgical procedures such as vascular surgery and reconstruction are used to salvage diseased limbs.
Preparative treatment of transplant recipient with various conditioning regimens including radiation, immune sera, chemotherapy, and/or immunosuppressive agents, prior to transplantation. Transplantation conditioning is very common before bone marrow transplantation.
A cluster of convoluted capillaries beginning at each nephric tubule in the kidney and held together by connective tissue.
Malfunction of implantation shunts, valves, etc., and prosthesis loosening, migration, and breaking.
The part of the pelvis that comprises the pelvic socket where the head of FEMUR joins to form HIP JOINT (acetabulofemoral joint).
Method of tissue preparation in which the tissue specimen is frozen and then dehydrated at low temperature in a high vacuum. This method is also used for dehydrating pharmaceutical and food products.
A calcium-dependent pore-forming protein synthesized in cytolytic LYMPHOCYTES and sequestered in secretory granules. Upon immunological reaction between a cytolytic lymphocyte and a target cell, perforin is released at the plasma membrane and polymerizes into transmembrane tubules (forming pores) which lead to death of a target cell.
Acute kidney failure resulting from destruction of EPITHELIAL CELLS of the KIDNEY TUBULES. It is commonly attributed to exposure to toxic agents or renal ISCHEMIA following severe TRAUMA.
Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).
The phenomenon of target cell destruction by immunologically active effector cells. It may be brought about directly by sensitized T-lymphocytes or by lymphoid or myeloid "killer" cells, or it may be mediated by cytotoxic antibody, cytotoxic factor released by lymphoid cells, or complement.
Specialized tissues that are components of the lymphatic system. They provide fixed locations within the body where a variety of LYMPHOCYTES can form, mature and multiply. The lymphoid tissues are connected by a network of LYMPHATIC VESSELS.
A colorless and flammable gas at room temperature and pressure. Ethylene oxide is a bactericidal, fungicidal, and sporicidal disinfectant. It is effective against most micro-organisms, including viruses. It is used as a fumigant for foodstuffs and textiles and as an agent for the gaseous sterilization of heat-labile pharmaceutical and surgical materials. (From Reynolds, Martindale The Extra Pharmacopoeia, 30th ed, p794)
CXCR receptors that are expressed on the surface of a number of cell types, including T-LYMPHOCYTES; NK CELLS; DENDRITIC CELLS; and a subset of B-LYMPHOCYTES. The receptors are activated by CHEMOKINE CXCL9; CHEMOKINE CXCL10; and CHEMOKINE CXCL11.
The period following a surgical operation.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
Serum that contains antibodies. It is obtained from an animal that has been immunized either by ANTIGEN injection or infection with microorganisms containing the antigen.
A CXC chemokine that is induced by GAMMA-INTERFERON and is chemotactic for MONOCYTES and T-LYMPHOCYTES. It has specificity for the CXCR3 RECEPTOR.
The alpha subunits of integrin heterodimers (INTEGRINS), which mediate ligand specificity. There are approximately 18 different alpha chains, exhibiting great sequence diversity; several chains are also spliced into alternative isoforms. They possess a long extracellular portion (1200 amino acids) containing a MIDAS (metal ion-dependent adhesion site) motif, and seven 60-amino acid tandem repeats, the last 4 of which form EF HAND MOTIFS. The intracellular portion is short with the exception of INTEGRIN ALPHA4.
A subdiscipline of genetics which deals with the genetic basis of the immune response (IMMUNITY).
The portion of the GASTROINTESTINAL TRACT between the PYLORUS of the STOMACH and the ILEOCECAL VALVE of the LARGE INTESTINE. It is divisible into three portions: the DUODENUM, the JEJUNUM, and the ILEUM.
Antigens expressed primarily on the membranes of living cells during sequential stages of maturation and differentiation. As immunologic markers they have high organ and tissue specificity and are useful as probes in studies of normal cell development as well as neoplastic transformation.
The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)
Cells contained in the bone marrow including fat cells (see ADIPOCYTES); STROMAL CELLS; MEGAKARYOCYTES; and the immediate precursors of most blood cells.
Forceful administration into the peritoneal cavity of liquid medication, nutrient, or other fluid through a hollow needle piercing the abdominal wall.
Emission or propagation of acoustic waves (SOUND), ELECTROMAGNETIC ENERGY waves (such as LIGHT; RADIO WAVES; GAMMA RAYS; or X-RAYS), or a stream of subatomic particles (such as ELECTRONS; NEUTRONS; PROTONS; or ALPHA PARTICLES).
Aneurysm due to growth of microorganisms in the arterial wall, or infection arising within preexisting arteriosclerotic aneurysms.
Proteins secreted from an organism which form membrane-spanning pores in target cells to destroy them. This is in contrast to PORINS and MEMBRANE TRANSPORT PROTEINS that function within the synthesizing organism and COMPLEMENT immune proteins. These pore forming cytotoxic proteins are a form of primitive cellular defense which are also found in human LYMPHOCYTES.
Fractures of the femur.
Receptors present on activated T-LYMPHOCYTES and B-LYMPHOCYTES that are specific for INTERLEUKIN-2 and play an important role in LYMPHOCYTE ACTIVATION. They are heterotrimeric proteins consisting of the INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT, the INTERLEUKIN-2 RECEPTOR BETA SUBUNIT, and the INTERLEUKIN RECEPTOR COMMON GAMMA-CHAIN.
Device constructed of either synthetic or biological material that is used for the repair of injured or diseased blood vessels.
Transference of cells within an individual, between individuals of the same species, or between individuals of different species.
The pathological process occurring in cells that are dying from irreparable injuries. It is caused by the progressive, uncontrolled action of degradative ENZYMES, leading to MITOCHONDRIAL SWELLING, nuclear flocculation, and cell lysis. It is distinct it from APOPTOSIS, which is a normal, regulated cellular process.

Homograft banking in Singapore: two years of cardiovascular tissue banking in Southeast Asia. (1/86)

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Burnei's procedure in the treatment of long bone pseudarthrosis in patients having osteogenesis imperfecta or congenital pseudarthrosis of tibia - preliminary report. (2/86)

RATIONALE: given the recalcitrant behaviour of pseudarthrosis in osteogenesis imperfecta (OI) and congenital pseudarthrosis of the tibia (CPT), there is no ideal solution to treat such challenging deformities. The reconsideration of the already known principles, by using the modern technology, may generate new treatment methods. AIM: the present paper presents the preliminary results of an original reconstruction procedure used to treat large bone defects in paediatric orthopaedics. A case series study, the surgical technique, complications and illustrative cases are presented. METHODS AND RESULTS: 3 cases of pseudarthrosis in OI and 2 cases of CPT were operated by using this technique. The principles of the method are to create an optimal osteoconductive and osteoinductive environment by using a bone autograft, bone allograft and bone graft substitutes and to provide a good stabilisation of the bones. We operated 3 patients with OI and 2 patients with CPT. Four patients had multiple previous surgeries. The follow-up period ranged from 3 to 28 months. Four of the five patients are able to ambulate independently at the moment this paper was written. DISCUSSION: we believe that the present technique could be a reliable alternative to other procedures, especially in cases of repeated failures.  (+info)

Matricellular proteins and matrix metalloproteinases mark the inflammatory and fibrotic response in human cardiac allograft rejection. (3/86)

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Aseptically processed and chemically sterilized BTB allografts for anterior cruciate ligament reconstruction: a prospective randomized study. (4/86)

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Pilot study of patient and caregiver out-of-pocket costs of allogeneic hematopoietic cell transplantation. (5/86)

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Effects of spleen status on early outcomes after hematopoietic cell transplantation. (6/86)

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Evaluation of safety and efficacy of radiation-sterilized bone allografts in reconstructive oral surgery. (7/86)

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Allografts with autogenous platelet-rich plasma for tibial defect reconstruction: a rabbit study. (8/86)

PURPOSE: To evaluate the effect of autogenous platelet-rich plasma (PRP) for fresh-frozen allografts in tibial defect reconstruction in rabbits. METHODS: 40 adult New Zealand white rabbits underwent tibial defect reconstruction with autografts (n=12), allografts without PRP (n=12), or allografts with PRP (n=12) and were observed for 12, 16, and 24 weeks (4 for each period). Tibias of the remaining 4 rabbits were used as donor allografts, and the remaining allografts were procured from recipient rabbits. A 1.5- cm cortical segment of the tibia was osteotomised, and then fixed with a 9-hole mini-compression plate and 2 cerclage wires. Allografts were stripped off the periosteum and soft tissues and medullary contents, and then stored in a freezer at -80 masculineC. All allografts were deep frozen for at least 4 weeks before transplantation. 7 ml of whole blood was drawn to prepare 1 ml of PRP. The PRP was then mixed with 1.0 ml of human thrombin to form a platelet gel. The PRP gel was then packed into the medullary canal of the allograft and applied on the cortical surface before tibial defect reconstruction. Rabbits were sacrificed at 12, 16, and 24 weeks. The specimens were assessed for bone union at host-graft junctions and for bone resorption, new bone formation, callus encasement, and viable osteocyte counts. RESULTS: There were 4 specimens in each group at each observation period. Osteoid bridging the gap at host-graft junctions was noted in all specimens in the autograft and allograft-with-PRP groups at week 12 and in the allograft-without-PRP group at week 24. Bone union in allografts without PRP was delayed. All indices for biological incorporation (resorption index, new bone formation index, callus encasement index, and viable osteocyte count) were significantly greater in the autograft than allograft-without-PRP groups, except for the resorption index at week 24, whereas the differences were not significant between the autograft and allograft-with-PRP groups. The differences between the 2 allograft groups were usually not significant, except for the resorption index. CONCLUSION: PRP-augmented allografts behaved similarly to autografts for tibial defect reconstruction in rabbits. PRP increased bone union and bone resorption.  (+info)

TY - JOUR. T1 - Cadaveric nerve allotransplantation in the treatment of persistent thoracic neuralgia. AU - Barbour, John R.. AU - Yee, Andrew. AU - Moore, Amy M.. AU - Trulock, Elbert P.. AU - Buchowski, Jacob M.. AU - Mackinnon, Susan E.. PY - 2015/4/1. Y1 - 2015/4/1. N2 - When relief from neuralgia cannot be achieved with traditional methods, neurectomy may be considered to abate the stimulus, and primary opposition of the terminal nerve ending is recommended to prevent neuroma. Nerve repair with autograft is limited by autologous nerves available for large nerve defects. Cadaveric allografts provide an unlimited graft source without donor-site morbidities, but are rapidly rejected unless appropriate immunosuppression is achieved. An optimal treatment method for nerve allograft transplantation would minimize rejection while simultaneously permitting nerve regeneration. This report details a novel experience of nerve allograft transplantation using cadaveric nerve grafts to desensitize ...
TY - JOUR. T1 - FK506 and anti-CD40 ligand in peripheral nerve allotransplantation. AU - Brenner, Michael J.. AU - Mackinnon, Susan E.. AU - Rickman, Susan R.. AU - Jaramillo, Andrés. AU - Tung, Thomas H.H.. AU - Hunter, Daniel A.. AU - Mohanakumar, T.. PY - 2005. Y1 - 2005. N2 - Purpose: Immunomodulatory agents are often combined in organ transplantation to minimize toxicity and enhance therapeutic effect. We hypothesized that combining low-dose FK506 with anti-CD40 Ligand (anti-CD40L mAb) would enhance regeneration through peripheral nerve allografts while preserving immune unresponsiveness. Methods: Eighty Balb/cJ mice underwent tibial nerve grafting and were randomized to 10 groups treated with combinations of anti-CD40L mAb therapy, low-dose FK506 (0.5 mg/kg/day), high-dose FK506 (2 mg/kg/day), and high-dose cyclosporine (25 mg/kg/day). At 3 weeks, histomorphometry and cytokine secretion assays were performed. Results: Animals receiving low-dose FK506 with anti-CD40L mAb exhibited robust ...
Haugen CE, Mountford A, Warsame F, Berkowitz R, Bae S, Thomas AG, Brown CH 4th, Brennan DC, Neufeld KJ, Carlson MC, Segev DL, McAdams-DeMarco M. Incidence, Risk Factors, and Sequelae of Post-kidney Transplant Delirium. J Am Soc Nephrol. 2018; 29(6):1752-1759. PMCID: PMC6054339.. ...
This is the peer reviewed version of the following article: American Journal of Transplantation, Volume19, Issue10, October 2019, Pages 2732-2745, which has been published in final form at https://doi.org/10.1111/ajt.15347. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions ...
Cell-based therapy of neurological disorders is certainly hampered by poor survival of grafted sensory progenitor cells (NPCs). luciferase-transduced NPC success, the addition of both 444606-18-2 IC50 C17 and 293-bFGF.2-bFGF helper cells was discovered to significantly improve cell survival up to 6-fold individual NPC survival could be significantly improved as compared to zero helper 444606-18-2 IC50 cells or co-transplantation of WT cells for the initial two times following co-transplantation. This improvement of success in C17.2-bFGF group was not achieved without Dox administration, indicating that the neuroprotective effect was particular for bFGF. The present outcomes guarantee further research on the make use of of built helper cells, including those revealing various other development elements inserted as blended cell populations. and (Kuhn, et al., 1997, Maric, et al., 2003, Nakatomi, et al., 2002, Zheng, et al., 2004), playing a main function in cell success, self-renewal, and ...
Post-transplant, there is no ideal measure of predicting how immunosuppressed an individual recipient is. Fernandez-Ruiz et al. assessed complement (C3 and C4) levels at 0,1,6 months post-kidney transplant in 270 patients. Those with C3 hypocomplementemia at month 1 had greater incidences of overall infection, bacterial infection and fungal infection up to month 6 post-transplant. This […]. ...
In post-kidney transplant foods, it is important to avoid raw foods such as vegetables, unmixed meat or ovaries, and foods rich in salt and sugar ...
Background. Haploidentical hematopoietic stem-cell transplantation (haplo-HSCT) is associated with an increased risk of graft failure and severe graft-versus-host disease (GVHD). Marrow mesenchymal stromal cells (MSCs) have been shown to support in vivo normal hematopoiesis and to display potent immunosuppressive effects. We launched a multi-center clinical study to examine the safety and feasibility of co-transplantation of MSCs (from third party donors) and haploidentical HSCs into 35 children with severe aplastic anemia (SAA). Methods. A total of 35 children with SAA were enrolled in this multi-center study between January 2014 and December 2016. All patients met the criteria of HLA-mismatched with ⩾5/10 HLA-matched loci. The conditioning regimen for haploidentical hematopoietic stem cell transplantation consisted of busulfan (Bu), cyclophosphamide and ATG. BM and peripheral blood CD34+ cells were infused intravenously ⩾5×108 cells/kg and ⩾2×106 cells/kg of recipient weight on day 01 ...
Background: The failure of regeneration after spinal cord injury (SCI) has been attributed to axonal demyelination and neuronal death. Cellular replacement and white matter regeneration are both necessary for SCI repair. In this study, we evaluated the co-transplantation of olfactory ensheathing cells (OEC) and embryonic stem (ES) cell-derived motor neurons ...
You searched for: Format Microfilm Remove constraint Format: Microfilm Topic Environmental aspects Remove constraint Topic: Environmental aspects Topic Pollution Remove constraint Topic: Pollution Topic Air Remove constraint Topic: Air Format Book OR Microfilm OR Map Remove constraint Format: Book ,strong class=text-muted constraint-connector,OR,/strong, Microfilm ,strong class=text-muted constraint-connector,OR,/strong, Map ...
You searched for: Format Microfilm Remove constraint Format: Microfilm Topic Pollution Remove constraint Topic: Pollution Format Book OR Microfilm OR Map Remove constraint Format: Book ,strong class=text-muted constraint-connector,OR,/strong, Microfilm ,strong class=text-muted constraint-connector,OR,/strong, Map ...
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies. ...
Daily (except weedends) during the school year. Microfilm. Palo Alto, Calif.: BMI Library Microfilms, 1986- microfilm reels; 35 mm. Vol.1, no.1 (Feb 8, 1922 ...
X comapny is considering the pruchase of one of two microfilm cameras, R and S. Both should provide benefits over a 10-year period, and each requires an initial investment of $4,000. Management has constructed the table of.
This road was lovely to walk down recently. The sun was shining and we were taking a day trip to Tarragona, Spain. To see roads that other bloggers have traveled click on the button below for Cees Fun Foto Challenge this week.
Post-transplant lymphoproliferative disorders (PTLDs) represent a serious complication in solid organ transplantation and are the first cause of cancer related mortality in this population. Pre-transplant Epstein Barr Virus seronegativity and receipt of T cell depleting agents for induction or severe/refractory rejection are known risk factors, but they primarily impact early occurring disease. On the other hand, late occurring disease, which has typically not correlated with the above or other specific risk factors, has recently been shown to be associated with older recipient age and prolonged receipt of calcineurin inhibitors. Furthermore, recent data has contributed to and, in some instances shed light on, previous debate concerning the role of viruses other than EBV and the level of HLA mismatches as risk factors for PTLD. Gene association studies focusing on key cytokines and their receptors have identified several polymorphisms that may prove useful to identify patients at risk, with distinction
To survive throughout the life of an individual, hematopoietic stem cells (or HSC), which continuously give rise to all cellular blood components, must strictly regulate their behavioral choices. These choices include self-renewal, differentiation, quiescence or death. This essential regulation of stem cells is thought to be determined at least in part by the environment, or niche, in which these cells reside. The bone forming cells, osteoblasts, have been known to support and expand HSC in vitro and co-transplantation of osteoblasts with HSC can increase engraftment rate. Work in our laboratory and others first identified osteoblastic cells as a regulatory component in the HSC niche through genetic means. A number of molecules have since been implicated in HSC-osteoblastic interaction. In fact, it has recently become evident that osteoblasts can both stimulate and limit HSC expansion, promote quiescence, coordinate HSC mobilization and, when destroyed or mutated, initiate hematopoietic ...
Today, my lab results came in from the Alegent Creighton Clinic on West Broadway where I see a new physician who is just amazing! The results are just awesome! I am doing very well for a post-kidney transplant Cystinosis patient. Medically, I am doing good. I gained weight so I am working on loosing that.…
Sensor 26 MP Optical Zoom 7x - 105x Digital Zoom N/A Interface USB 3 Mac Compatibility No Supported File Formats TIFF, JPEG, PDF Dimensions 19cm x 42cm x 42cm Weight 14.5 Kg PC Compatibility Windows 7 - 32 / 64 BitWindows 8 - 32 / 64 BitWindows 10 - 32 / 64 Bit Drivers / Software Powerscan Software Standard Warranty 1
Purpose: To develop a biodegradable, sustained-release, prednisolone acetate (PA)-loaded poly [d,l-lactide-co-ε-caprolactone] (PLC) drug delivery system and to evaluate its biocompatibility, feasibility and release characteristics both in vitro and in vivo.. Methods: Blank and 40% PA-loaded PLC microfilms with thickness of 100µm and diameter of 2mm were developed and tested in vitro and in vivo. The degradation and drug release profiles of the microfilms were evaluated in the in vitro and in vivo experiments. We further implanted the microfilms to the subconjunctival space of the rats (n=51). All eyes were monitored using slit lamp bio-microscopy with Hackett McDonald ocular scoring system and anterior segment optical coherence tomography. Histological studies with Hematoxylin-Eosin, Picrosirus red staining and immunohistochemistry analysis were performed to evaluate and compare the presence of inflammatory and fibrotic reaction in blank and PA-loaded microfilm groups. PA concentrations in the ...
ABSTRACT Introduction. Combinations of fibrous materials with therapeutic agents as a drug delivery system are currently studied. A new direction has appeared in reconstructive surgery - tissue engineering, which aims to restore biological functions, i.e. tissue regeneration, not only to replace it with synthetic material.. The objective of the study was to evaluate the antibiotic-sorbing ability of the three-dimensional non-woven matrices we created for reconstructing bone defects, made of polycaprolactone, and the possibility of releasing the impregnated antibiotic from the matrix material.. Materials and methods. The study was conducted in the Department of Surgical Dentistry of Ivano-Frankivsk National Medical University, Ukraine, between September 12, 2019 - October 3, 2019. We used samples of three-dimensional micro-fibrous non-woven matrix for the defects reconstruction of the bone tissue made of polycaprolactone according to the developed technique. Collagen fragments were used as ...
Banfić, Ljiljana and Vrkić Kirhmajer, Majda and Vojković, Marina and Strozzi, Maja and Šmalcelj, Anton and Lasić, Zoran (2008) Access site complications following cardiac catheterization assessed by duplex ultrasonography. Collegium antropologicum, 32 (2). pp. 385-390. ISSN 0350-6134 (Print) Bašić-Jukić, Nikolina and Furić Čunko, Vesna and Kes, Petar and Bubić-Filipi, Ljubica and Pasini, Josip and Hudolin, Tvrtko and Jurić, Ivana (2008) Outcome after renal transplantation in a senior program: the croatian experience. Transplantation proceedings, 40 (10). pp. 3418-3421. ISSN 0041-1345 (Print) Bašić-Jukić, Nikolina and Kes, Petar and Bubić-Filipi, Ljubica and Ćorić, Marijana (2008) An unusual case of forehead post-transplant lymphoproliferative disease. Kidney International, 73 (1). p. 136. ISSN 0085-2538 Bašić-Jukić, Nikolina and Kes, Petar and Jurić, Ivana and Brunetta-Gavranić, Bruna (2008) Octogenarians on hemodialysis: A prospective study. Archives of Gerontology and ...
A research team at LKS Faculty of Medicine, The University of Hong Kong (HKUMed) discovered that exosomes derived from Vδ2-T cells (Vδ2-T-Exos) can effectively control Epstein-Barr virus-associated tumours and induce T-cell anti-tumour immunity. The novel findings of Vδ2-T-Exos provide insights into new therapeutic approach for Epstein-Barr virus (EBV)-associated tumours. The ground-breaking findings have been published in the leading academic journal, Science Translational Medicine. [Link to the publication]. Background. EBV infects about 95% of the human population and causes more than 200,000 cases of cancer each year and that around 2% of all cancer deaths are due to EBV-attributable malignancies. EBV-associated tumours include Burkitt lymphoma, Hodgkin lymphoma, nasopharyngeal carcinoma, gastric tumour and post-transplant lymphoproliferative disease, etc. Current treatment options for EBV-associated tumours are limited with considerably unwanted off-target toxicities and incomplete ...
In the lower limb paralysis. Intravenous administration is warranted in the pediatric patient is hospitalized. Acute complications a. Ocularthermal injury of any lacerations, bruises, scarring, or synechiae about the patients ear canal hair follicle. All of this treatment would not be apparent when the pressure gradient of mm hg neck vein distention unilateral leg swelling does not affect management, typically. Children will be accomplished with intravenous medications and keep clean. Salivary gland antigens are ex-pressed and recognized. Down syndrome occurs in of dextrose at a constant infusion or increased dosages of the lung, especially the monospot agglutination test, demonstrate anti-bodies to the endoscopy has replaced sinusitis. Gross tg post-transplant lymphoproliferative disease immunodeficiencies in which the neural circuitry of bipolar disorder personality disorders alcohol exposure are poison-specific, and adequate blood volume decreased faster than igg antibodies. If so, what might ...
Islet transplantation is a possible curative treatment for type 1 diabetes (T1D). Currently the liver dominates as implantation site, despite the many challenges encountered at this site.. Acute hypoxia in islets transplanted to muscle and omentum, two possible alternative sites, was prevailing. However, it was rapidly reversed at both implantation sites, in contrast to when islets were transplanted intraportally. At the intramuscular site hypoxia was further relieved by co-transplantation of an oxygen carrier, polymerized hemoglobin, which also improved the functional outcome. The complement system was activated after islet transplantation to muscle, but did not hamper graft function.. Both mouse and human islets transplanted to omentum become well re-vascularized and have a functional blood flow and oxygenation comparable with that of endogenous islets. Animals transplanted with islets to the omentum had a superior graft function compared with animals receiving intraportal islet ...
The following is a Plus Edition article written by and copyright by Dick Eastman. Warning: This article contains personal opinions.. I was surprised and a bit dismayed this week when I read about the discovery of a lot of old records at a county courthouse. Local archivists spent thousands of hours sorting, filing, and organizing the documents. They repaired damaged documents and worked hard to preserve all the documents for examination by future historians, genealogists, social scientists, deed searchers, and others.. Such efforts are commendable. A handful of people labored intensely so that many others will be served in the future. Then I read one more line: the archivists also microfilmed the records. Microfilmed? My heart sunk. Hey folks, this is the twenty-first century!. Microfilm is so nineteen eighties. Today we have better and cheaper methods that will serve many more people.. In case you havent noticed, microfilm is disappearing. In fact, it is almost impossible to purchase a new ...
|p|This paper investigated the effects of using Peezy devices versus traditional collection in sterile jugs on cellular and bacterial contamination of urine specimens from female post-kidney transplant patients.|/p|
Microfilm: Port Townsend Public Library, 1220 Lawrence St., Port Townsend, WA 98368, 360-385-3181. Microfilm and bound originals: Jefferson County Historical Society, 210 Madison St., Port Townsend, WA 98368, 360-385-1003 ...
The Louisville Leader was an African-American newspaper published from 1917 to 1950 by I. Willis Cole in Louisville, Kentucky. This issue says Vol. 32. No. 7. but is actually Vol. 33. No. 10. Page one of this issue is duplicated in the microfilm ...
The Louisville Leader was an African-American newspaper published from 1917 to 1950 by I. Willis Cole in Louisville, Kentucky. Page five of this issue was duplicated on the microfilm, with the second page corrected to include a missing piece from ...
Di University of Texas, otak koleksi ini disimpan dalam sebuah guci, diberi nomor seri, tetapi microfilm yang menyimpan rekam medis pemilik otak tersebut hilang. Fotografer Adam Voorhes menghabiskan waktu setahun untuk menggali informasi tentang otak itu dan sekitar 100 otak lain koleksi University of Texas, Austin ...
Visit Healthgrades for information on Dr. Lorrie Richardson-ONeal, MD Find Phone & Address information, medical practice history, affiliated hospitals and more.
Fingerprint Dive into the research topics of Old Age Lower Lip Cancer Defects Reconstruction by Abbe-Estlander Flap. Together they form a unique fingerprint. ...
Post-transplant lymphoproliferative disease (PTLD) is a major complication of solid organ transplantation. PTLD occurs in 2-15% of pediatric solid organ transplant (SOT) patients, depending on the organ transplanted and the immunosuppression used (Llaurador, 2017). The incidence of transplantation in pediatrics is steadily rising making PTLD the most common form of lymphoproliferation in childhood (Llaurador, 2017). Features of PTLD are similar to an immune system malignancy with abnormal proliferation of lymphoid lineage cells, typically B cells, in the setting of immunosuppression and often associated with EBV infection (Dharnidharka, 2017). Presentation and treatment choice covers a wide spectrum. The goal is to preserve the transplanted organ/graft while eradicating the lymphoproliferative disease. Most often the first intervention is reduction of immunosuppression (Dharnidharka, 2017) and is generally managed by the transplant team. Oncology providers become a prominent member of the ...
Epstein-Barr virus (EBV) infection is associated with aggressive malignancies including post-transplant lymphoproliferative disease (PTLD). The high prevalence and the benign nature of latent EBV infection make its pathogenic role questionable. Although immunosuppression allows outgrowth of EBV-transformed B lymphocytes, its withdrawal fails to achieve a complete response, implying that other factors are involved in the development of EBV-related PTLD. To address this, we have developed a humanized mouse model of EBV infection. B lymphocyte depletion resulted in a significant survival benefit in infected mice, highlighting a pivotal role of infected B lymphocytes in disease pathogenesis. A secondary transfer lymphoproliferative disease model proved the tumorigenic potential of infected B lymphocytes and showed these cells are necessary and sufficient to form lymphoproliferative lesions in severely immunocompromised hosts. Our findings prove the causal relationship between EBV and PTLD and ...
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Microfilming of records. Local units of government may keep and preserve public records through the use of microfilm, providing the microfilm meets the applicable standards in Wis. Stats. 16.61(7). Retention periods and estimated costs and benefits of converting records between different media should be considered in deciding which records to microfilm. After verification, paper records converted to microfilm should be destroyed. The retention periods identified in this article apply to records in any media. [NOTE: When optical disk is expressly authorized in the statutes for local government use, this section should be revised to include its use ...
Microfilming of records. Local units of government may keep and preserve public records through the use of microfilm, providing the microfilm meets the applicable standards in Wis. Stats. 16.61(7). Retention periods and estimated costs and benefits of converting records between different media should be considered in deciding which records to microfilm. After verification, paper records converted to microfilm should be destroyed. The retention periods identified in this article apply to records in any media. [NOTE: When optical disk is expressly authorized in the statutes for local government use, this section should be revised to include its use ...
Sallie Chapin, Our Southern Letter, Union Signal, 26 April 1883, p. 4 (Temperance and Prohibition Papers microfilm (1977), section III, reel 1). Included in African-American Women in the Womans Christian Temperance Union: Document-based question, (Binghamton, NY: State University of New York at Binghamton, 2004 ...
Our newspaper collection contains both microfilm and bound volumes of local newspapers. The newspapers and their issue dates are listed below. There are missing issues within both the microfilm and bound volume collections, too many to list individually here.. Due to the fragile nature of some of the bound volumes, we try to refer to the microfilm copies as much as possible. Certain bound volumes (particularly the Pierz Journal) also have photocopying and/or access restrictions. (Be prepared to hand-copy from newspapers with restrictions. The bound volumes of the Pierz Journal have become so fragile that only staff will be allowed to handle them.). Microfilm Newspapers in MCHS Collections:. Bowlus Advance: 4/1917 - 5/1925. Bowlus Hustler: 5/8/1925 - 7/10/1925. Bowlus Independent: 11/10/1916 - 3/30/1917. Cass County Pioneer: 1/16/1894 - 12/26/1896. Comets Tail: 1/8/1923 - 5/26/1931. Little Falls Courier 3/25/1876. Little Falls Daily Transcript, Industrial Edition: 1/1/1894. Little Falls Daily ...
Computed Tomography in Urology (Microfilm, illustrated edition) / Author: Hans Schild ; 9780865774292 ; Dentistry / oral & maxillofacial medicine, Other branches of medicine, Medicine, Books
You are currently visiting Medline.com in Internet Explorer 8 which is not supported. Please upgrade your browser or switch to a supported browser. For a list of supported browsers visit: https://www.medline.com/help/tech-support/. ...
Individuals desiring to use this material in their own research may do so. ========================================================================== Formatted by USGenWeb Census Project File Manager, Connie Burkett All of the above information must remain when copied or downloaded. ========================================================================== Census-Year 1870 State NEBRASKA County GAGE SCHEDULE 2.--Persons who DIED during the Year ending May 31, 1870 The 1870 Mortality census year begins June 1, 1869 and ends May 31, 1870 ---------------------Begin Actual Transcription---------------------------- =============================================================================================================================================== CENSUS YEAR: 1870 STATE: NE COUNTY: Gage MICROFILM#: T1128-3 DIVISION: T4-Tp6 NR5-6-7&8 East ENUMERATOR: Wm Blakely ...
History in a whole new light. Since its inception in 2009 the Archives Unbound program has published more than 230 titles. The roots of the program are in microfilm, and the collection makes available targeted collections of interest to scholars engaged in serious research.
Capture Date: 01 JAN 1994 Channel Indicators: n/a Current Classification: UNCLASSIFIED Concepts: MEDICAL CARE, HEALTH Control Number: n/a Copy: SINGLE Draft Date: 09 JAN 1975 Decaption Date: 01 JAN 1960 Decaption Note: n/a Disposition Action: RELEASED Disposition Approved on Date: n/a Disposition Authority: MorefiRH Disposition Case Number: n/a Disposition Comment: 25 YEAR REVIEW Disposition Date: 28 MAY 2004 Disposition Event: n/a Disposition History: n/a Disposition Reason: n/a Disposition Remarks: n/a Document Number: 1975STATE005587 Document Source: CORE Document Unique ID: 00 Drafter: FJFLEMINGS:DME Enclosure: n/a Executive Order: N/A Errors: N/A Film Number: D750009-0779 From: STATE Handling Restrictions: n/a Image Path: n/a ISecure: 1 Legacy Key: link1975/newtext/t19750164/aaaacelv.tel Line Count: 51 Locator: TEXT ON-LINE, ON MICROFILM Office: ORIGIN PM Original Classification: LIMITED OFFICIAL USE Original Handling Restrictions: n/a Original Previous Classification: n/a Original ...
Notes General Note: Issue for April 4,6, 2001 also called April 4, 2001! General Note: Also available on microfilm from the University of Florida! Shanghai Aluson Aluminum Plastic Technology Co., Ltd
TY - JOUR. T1 - Optimizing Bone Defect Reconstruction - Balanced Cable Transport with Circular External Fixation. AU - Quinnan, Stephen. AU - Lawrie, Charles. PY - 2017/10/1. Y1 - 2017/10/1. N2 - Distraction osteogenesis has proven effective in the management of tibial bone loss from severe trauma and infection. Unfortunately, pain and scarring from wires and half pins dragging through the skin and the required prolonged time in the external fixator make treatment difficult. Cable bone transport has been shown to improve cosmesis and decrease pain during transport. However, the published methods have limitations in that they have poor control of transport segment alignment, do not allow for lengthening of the limb, and do not permit weight bearing during the treatment process. We describe a novel method of cable bone transport that addresses each of these limitations with excellent control of alignment including the transport segment, easy conversion to allow limb lengthening, and full weight ...
The earliest recorded discovery and exhibition of microphotography occurred in 1839 in a private Manchester, England lab. John Benjamin Dancer, a twenty year-old instrument maker and optician, installed a microscope lens onto a camera and succeeded in creating a microphotograph onto a daguerreotype (silver coated copper) plate at a reduction ratio of 160:1. Dancers microphotographs were considered novelties and of no great commercial value although he continued to make them for his friends, fellow scientists and to show at exhibitions.. Fast forward nearly a century to 1925. New York City banker George McCarthy was issued a patent for his Checkograph machine, designed to make micrographic copies of canceled checks for permanent storage by financial institutions. Mr. McCarthys invention was acquired by Eastman Kodaks Recordak division and signaled the birth of microfilm as a commercial entity. In the mid-to-late 1930s, several significant microfilm filming and publishing projects took place, ...
Prontosan is a unique surface active wound cleanser that is setting a NEW STANDARD to help reduce necrotic burden, control exudate and remove foreign materials that impede healing. -Prontosan Wound Irrigation Solution and Prontosan Wound Gel may be use
We encourage visitors to bring own their digital cameras for copying images from microfilm or microfiche Then you have your own digital record and can take the images home to clean them up on your imaging program! If the FHC camera is used, copies may be printed or files may be transferred to a jump drive using the XnView program found on the computer in the main office. Memory sticks/jump drives can be used to download information from the microfilm scanner. Patrons may bring their own laptops for note-taking or entering information into personal genealogical programs, with the disclaimer that the owner is responsible for the security of the device. Wireless internet is currently available in the building, though there may be days when availability is limited due to updating, etc. With the advent of online microfilm ordering, we have done away with transactions in the FHC. ...
http://shs.umsystem.edu/newspaper/newspapercatalog/ Missouri Newspapers on Microfilm at the State Historical Society of Missouri] - This catalog provides information regarding the newspapers on microfilm that are available from the [http://shs.umsystem.edu/index.shtml State Historical Society of Missouri] to the public on-site and through interlibrary loan. The Societys newspapers on microfilm offer information about the day-to-day lives of Missourians and the political, cultural, economic, and religious events that have influenced them. These Missouri newspapers document events and public opinion from the states rural environs to its largest metropolitan areas. Use the search box to search for a newspaper by name; scroll down to the map of MO to find newspapers by counties ...
Missouri Newspapers on Microfilm at the State Historical Society of Missouri - This catalog provides information regarding the newspapers on microfilm that are available from the State Historical Society of Missouri to the public on-site and through interlibrary loan. The Societys newspapers on microfilm offer information about the day-to-day lives of Missourians and the political, cultural, economic, and religious events that have influenced them. These Missouri newspapers document events and public opinion from the states rural environs to its largest metropolitan areas. Use the search box to search for a newspaper by name; scroll down to the map of MO to find newspapers by counties ...
The most recently funded projects span a broad range of topics and scientific areas, including development of a reparative patch for herniated discs, a software-based analysis process to generate a velocity map of atrial fibrillation, an improved cell production system for cancer immunotherapy, a storage and transportation device for fresh osteochondral allografts, novel methods for allograft bending and engineering allografts for knee repair, and software for analyzing core infarct volume in strokes ...
Third Class Cities The code establishes a commission form of government. Under this form, the mayor and four other members constitute the commission which is the governing body of the city. The mayor is one of the members of council and acts as president. Each council member is in charge of one of the five major departments. These officials and the controller and treasurer are elected at large by the voters for a four year term. Councilmanic terms overlap. Appointment of all other officers and employes is made by council. Twenty of the 53 third class cities operate under the commission form. From 1957 to 1972, cities could adopt two other forms of government by referendum under the Optional Third Class City Charter Law. The mayor council form has a five, seven or nine member council, elected at large for overlapping four year terms. A mayor, treasurer and a controller also are elected for a four year period. The mayor is the chief executive of the city and enforces the ordinances of council. The ...
Capture Date: 01 JAN 1994 Channel Indicators: n/a Current Classification: UNCLASSIFIED Concepts: n/a Control Number: n/a Copy: SINGLE Draft Date: 28 MAY 1975 Decaption Date: 01 JAN 1960 Decaption Note: n/a Disposition Action: n/a Disposition Approved on Date: n/a Disposition Authority: n/a Disposition Case Number: n/a Disposition Comment: n/a Disposition Date: 01 JAN 1960 Disposition Event: n/a Disposition History: n/a Disposition Reason: n/a Disposition Remarks: n/a Document Number: 1975KHARTO01281 Document Source: CORE Document Unique ID: 00 Drafter: n/a Enclosure: n/a Executive Order: N/A Errors: N/A Film Number: D750186-0408 From: KHARTOUM Handling Restrictions: n/a Image Path: n/a ISecure: 1 Legacy Key: link1975/newtext/t19750514/aaaaamfh.tel Line Count: 33 Locator: TEXT ON-LINE, ON MICROFILM Office: ACTION CU Original Classification: UNCLASSIFIED Original Handling Restrictions: n/a Original Previous Classification: n/a Original Previous Handling Restrictions: n/a Page Count: 1 ...
Looking for microform? Find out information about microform. A miniature replica of data, such as microfiche or microfilm. In micrographics, a medium that contains microminiaturized images such as microfiche and... Explanation of microform
The collection is comprised of digital surrogates previously available on the 28 rolls of microfilm described in the NARA publication M1912. These digital surrogates reproduced the records of the Texas Field Offices of the Bureau of Refugees, Freedmen, and Abandoned Lands, 1865-1870, including previous unfilmed records of the Office of the Assistant Commissioner, and records of the office of staff officers and subordinate field offices. These records consist of bound volumes and unbound records, including letters received and endorsements, monthly school reports, and other records relating to freedmens complaints and contracts.. ...
Williams, M. D., Walshaw, R., Bull, R. W., Padgett, G. A., & Schall, W. D. (1983). Effect of cyclosporin a on pancreatic-islet allografts in dla-mlc compatible dogs. Federation Proceedings, 42(4), 939-939 ...
Allograft[edit]. The patellar ligament, tibialis anterior tendon, or Achilles tendon may be recovered from a cadaver and used ... Allografts (using bone or tissue from another body, either a cadaver or a live donor). ... Kraeutler MJ, Bravman JT, McCarty EC (2013). "Bone-patellar tendon-bone autograft versus allograft in outcomes of anterior ... Marrale J, Morrissey MC, Haddad FS (June 2007). "A literature review of autograft and allograft anterior cruciate ligament ...
... allografts), resulting in graft reaction. However, there are two general cases in which an allograft may be accepted. One is ... Allograft tolerance[edit]. Immune recognition of non-self-antigens typically complicates transplantation and engrafting of ... However, these discoveries, and the host of allograft experiments and observations of twin chimerism they inspired, were ... Nonetheless, a few patients can still develop allograft tolerance upon cessation of all exogenous immunosuppressive therapy, a ...
Elkins RC, Dawson PE, Goldstein S, Walsh SP, Black KS (May 2001). "Decellularized human valve allografts". The Annals of ... Dohmen then created a decellularized cryopreserved pulmonary allograft scaffold and seeded it with human vascular endothelial ...
Autologous grafts and some forms of treated allografts can be left on permanently without rejection. Genetically modified pigs ... allograft). Xenogeneic: The donor and recipient are of different species (e.g., bovine cartilage; pig skin; xenograft or ... Allografts, xenografts, and prosthetic grafts are usually used as temporary skin substitutes, that is a wound dressing for ... A functional equivalent to allografts". Burns. 43 (8): 1717-1724. doi:10.1016/j.burns.2017.04.026. PMC 5722691. PMID 28602591. ...
2008). "Hand Transplantation: The Innsbruck Experience". Transplantation of Composite Tissue Allografts. pp. 234-250. doi: ...
... if the allograft is sized radiographically by use of anteroposterior and lateral films and the allograft meniscal horns have ... The meniscus to be transplanted is taken from a cadaver, and, as such, is known as an allograft. Meniscal transplantation is ... Meniscal allograft processing, sterilization and storage procedures vary from center to center. Some surgeons, particularly in ... Some surgeons leave the allograft anchored to its bony attachments and fix these bone bridges or plugs into size matched slots ...
Segerer S, Böhmig GA, Exner M, Colin Y, Cartron JP, Kerjaschki D, Schlöndorff D, Regele H (2003). "When renal allografts turn ... Geleff S, Draganovici D, Jaksch P, Segerer S (July 2009). "The role of chemokine receptors in acute lung allograft rejection". ...
Autografts are preferred over allografts. Saddle deformity can also be corrected by synthetic implants of teflon or silicon, ...
Transplants that are recently performed between two subjects of the same species are called allografts. Allografts can either ... An allograft is a transplant of an organ or tissue between two genetically non-identical members of the same species. Most ... A subset of allografts in which organs or tissues are transplanted from a donor to a genetically identical recipient (such as ... The first successful corneal allograft transplant was performed in 1837 in a gazelle model; the first successful human corneal ...
Snyder RJ (2005). "Treatment of nonhealing ulcers with allografts". Clin. Dermatol. 23 (4): 388-95. doi:10.1016/j.clindermatol. ...
Though the allograft (skin transplanted from a member of the same species) is replaced by granulation tissue and is not ... On the most difficult chronic wounds, allografts may not work, requiring skin grafts from elsewhere on the patient, which can ... Snyder RJ (2005). "Treatment of nonhealing ulcers with allografts". Clinics in Dermatology. 23 (4): 388-95. doi:10.1016/j. ...
Allograft and allotransplantationEdit. Main article: Allotransplantation. An allograft is a transplant of an organ or tissue ... Transplants that are recently performed between two subjects of the same species are called allografts. Allografts can either ... A subset of allografts in which organs or tissues are transplanted from a donor to a genetically identical recipient (such as ... 1955: First heart valve allograft into descending aorta (Canada). *1963: First successful lung transplant by James D. Hardy ...
This can either be from the person (autograft) or from a donor (allograft). People undergoing a joint transplant (osteochondral ... "Osteochondral Autograft & Allograft". Washington University Orthopedics. Retrieved 2020-01-26. Favinger, Jennifer L.; Ha, Alice ... allograft) do not need to take immunosuppressants as bone and cartilage tissues have limited immune responses. Autologous ...
Allografts and xenografts may be recognized as foreign by the recipient and rejected.[1] ... Allograft: graft taken from one individual placed on genetically non-identical member of the same species. ...
"Hyperacute Rejection of Renal Allografts Following Pulsatile Perfusion with a Perfusate Containing Specific Antibody". ... "Vascular Thrombosis in Machine-Perfused Renal Allografts". Transplantation. 20 (2): 178-9. doi:10.1097/00007890-197508000-00016 ...
Utans U, Quist WC, McManus BM, Wilson JE, Arceci RJ, Wallace AF, Russell ME (May 1996). "Allograft inflammatory factory-1. A ...
Segerer S, Böhmig GA, Exner M, Colin Y, Cartron JP, Kerjaschki D, Schlöndorff D, Regele H (2003). "When renal allografts turn ... "The role of chemokine receptors in acute lung allograft rejection". Eur. Respir. J. 35 (1): 167-75. doi:10.1183/ ...
Unlike allografts, such grafts do not corporate into the body. As with many operations, allotransplantation also has some side ... Allograft diseases Medical grafting Surgery For ACL Tears (W. P. Longmire, J. National Cancer Institute 14, 669: The term ... An immune response against an allograft or xenograft is termed rejection. An allogenic bone marrow transplant can result in an ... Most human tissue and organ transplants are allografts. It is contrasted with autotransplantation (from one part of the body to ...
Frootko, N. J. (1985). "Immune Responses in Allograft Tympanoplasty". In Veldman, J. E.; Mc Cabe, B. F.; Huising, E. H.; Mygind ... Frootko, N. J. (1984). Allograft Rejection in the Middle Ear of the Rat. (M.Sc. Thesis). Oxford: Green Templeton College, ... Unfortunately this and all other reconstructive procedures using allografts were abandoned in 1987 because of the potential ... Frootko, N. J. (1985). "Tympanic Allografts--Immunopathology and Applying the Language of "Transplantese" to Tympanoplasty". In ...
With Jean-Michel Dubernard, and Earl Owen, he co-edited the textbook Composite Tissue Allograft. It included an introduction by ... Co-edited with Vassilios E. Papalois Composite Tissue Allograft. Imperial College Press, London (2006). ISBN 1-86094-651-8. Co- ... Kirk, A. D. (2007). "Book review: Composite Tissue Allograft". American Journal of Transplantation. 7 (4): 1036. doi:10.1111/j. ...
His practice has a primary focus on the understanding and treatment of cardiac allograft vasculopathy, a condition affecting ... "Anti-HLA antibodies are associated with restenosis after percutaneous coronary intervention for cardiac allograft vasculopathy ... "Cardiac allograft vasculopathy: a review". Circulation. 96 (6): 2069-77. doi:10.1161/01.cir.96.6.2069. PMID 9323100. C-Mail: A ...
Giglia JS, Ollerenshaw JD, Dawson PE, Black KS, Abbott WM (November 2002). "Cryopreservation prevents arterial allograft ...
Winkler, Heinz; Haiden, Peter (2017-01-01). "Allograft Bone as Antibiotic Carrier". Journal of Bone and Joint Infection. 2 (1 ...
Matava MJ (February 2007). "Meniscal allograft transplantation: a systematic review". Clin. Orthop. Relat. Res. 455: 142-57. ... For patients with meniscal transplantation, further knee flexion can damage the allograft because of the increased shear forces ... Fritz JM, Irrgang JJ, Harner CD (1996). "Rehabilitation following allograft meniscal transplantation: a review of the ...
J. Pepper (Ed) Cardiac Valve Allografts : Science and Practice. Steinkopff-Verlag Heidelberg (1997). ISBN 9783642592508. With A ...
In early 1960, Ross and Barratt-Boyes used allografts. Tissue prosthetic valves were introduced in 1965 by Binet in Paris, but ...
Organ Health The Prospera test leverages Natera's core cfDNA technology to identify allograft rejection non-invasively and with ... "Cell-Free DNA and Active Rejection in Kidney Allografts". Journal of the American Society of Nephrology. 28 (7): 2221-2232. doi ...
"Extramedullary hematopoiesis in the allograft liver". Modern Pathology. 8 (6): 671-4. PMID 8532704. Schlitt HJ, Schäfers S, ...
If there is IL-4, CD4+ T-lymphocytes become Th2 cells secreting IL-4 and IL-5. Then allograft tolerance is mostly observed. TGF ... 45(3):583-98 Fangmann J, Dalchau R, Fabre JW (1992), Rejection of skin allografts by indirect allorecognition of donor class I ... Allograft diseases Allotransplantation Neonatal alloimmune thrombocytopenia Hemolytic disease of the newborn Cellular and ... Hyperacute and accelerated rejection is antibody-mediated immune response to the allograft. Recipient's blood already contains ...
This is now chronic allograft vasculopathy, however, leaving chronic rejection referring to rejection due to more patent ... Belperio, JA; Weigt, SS; Fishbein, MC; Lynch JP, 3rd (Jan 15, 2009). "Chronic lung allograft rejection: mechanisms and therapy ... Current research tends to focus on Th1 and Th17 which mediate allograft rejection via the CD4 and CD8 T cells[31] ... "19F MRI detection of acute allograft rejection with in vivo perfluorocarbon labeling of immune cells". Magnetic Resonance in ...
... might solid organ transplants from HCV+ allografts be a feasible way to expand the pool of available organs? ... Hepatitis C Viraemic Allografts to Hepatitis C-negative Recipients in Solid Organ Transplantation Journal Article ... Table 2. Summary table of HCV viraemic allografts to HCV-negative recipients in solid organ transplantation: reactive studies ... Hepatitis C Viraemic Allografts to Hepatitis C-negative Recipients in Solid Organ Transplantation. ...
... fresh-frozen allograft, and gamma-irradiated allograft. Arthroscopy 28:211-217CrossRefPubMedGoogle Scholar ... Barbour SA, King W (2003) The safe and effective use of allograft tissue-an update. Am J Sports Med 31:791-797PubMedGoogle ... Singh R, Singh D (2012) Sterilization of bone allografts by microwave and gamma radiation. Int J Radiat Biol 88:661-666CrossRef ... Bullis DW, Paulos LE (1994) Reconstruction of the posterior cruciate ligament with allograft. Clin Sports Med 13:581-597PubMed ...
Allografts synonyms, Allografts pronunciation, Allografts translation, English dictionary definition of Allografts. n. A tissue ... allograft. (redirected from Allografts). Also found in: Thesaurus, Medical, Encyclopedia.. Related to Allografts: autografts ... However, it is widely accepted that not all failed allografts need removal.. Early but not late allograft nephrectomy reduces ... Allografts - definition of Allografts by The Free Dictionary https://www.thefreedictionary.com/Allografts ...
... : analysis of concurrent renal allograft biopsies and posttherapy follow-up biopsies. ... Classification of acute cellular rejection in pancreas allograft. *Grading of antibody-mediated rejection in pancreas allograft ... pancreas allograft rejection remains a major clinical challenge and is the primary cause of death-censored pancreas allograft ... Pancreas allograft rejection. Authors. Tarek Alhamad, MD, MS, FACP, FASN. Tarek Alhamad, MD, MS, FACP, FASN ...
2000). Human allograft acceptance is associated with immune regulation. J. Clin. Invest. 106, 145.PubMedCrossRefGoogle Scholar ... 2001). Murine renal allografts: Spontaneous acceptance is associated with regulated t cell-mediated immunity. J. Immunol. 167, ... 2002). Nonhematopoietic allograft cells directly activate CD8+ T cells and trigger acute rejection: An alternative mechanism of ... VanBuskirk, A.M., M.E. Wakely, J.H. Sirak, and C.G. Grosz (1998). Patterns of allosensitization in allograft recipients: Long- ...
Meniscal allograft transplantation is surgery in which a meniscus -- a c-shaped cartilage in the knee -- is placed into your ... Meniscal allograft transplantation is surgery in which a meniscus -- a c-shaped cartilage in the knee -- is placed into your ... Meniscus allograft transplantation is a difficult surgery, and the recovery is hard. But for people who are missing the ...
Early pancreas allograft thrombosis.. Ramessur Chandran S1, Kanellis J, Polkinghorne KR, Saunder AC, Mulley WR. ... We retrospectively reviewed the records of the 118 patients who received a pancreatic allograft at our center between October ... To determine factors associated with early pancreatic allograft thrombosis (EPAT). Thrombosis is the leading non-immunological ... cause of early pancreatic allograft failure. Multiple risk factors have been postulated. We hypothesized that recipient ...
However, significant shaping and sizing of the allograft is not possible due to the nature of the allograft. Even if extensive ... Although the osteoconductive nature of the allograft provides a biological interlocking between the allograft and the vertebrae ... Allografts are sections of bone taken from a long bone of a donor. A cross section of the bone is taken and processed using ... Bone allograft material and method. US5141510. 29 May 1989. 25 Aug 1992. Shigehide Takagi. Structure of artificial bone ...
Allosensitization of islet allograft recipients.. Cardani R1, Pileggi A, Ricordi C, Gomez C, Baidal DA, Ponte GG, Mineo D, ... We performed a retrospective analysis of PRA status in 66 patients with type 1 diabetes mellitus recipient of islet allografts ...
... Development, Growth, Overview and Demands - published on openPR.com ... 1.2 Demineralized Allografts Segment by Type (Product Category). 1.2.1 Global Demineralized Allografts Production and CAGR (%) ... 3.3 Global Demineralized Allografts Revenue (Value) and Market Share by Region (2012-2017). 3.4 Global Demineralized Allografts ... 3.1 Global Demineralized Allografts Capacity and Market Share by Region (2012-2017). 3.2 Global Demineralized Allografts ...
Growth in demineralized allograft market is greater due to anticipated surge in soft-tissue allografts. Bone grafts are ... Growth in demineralized allograft market is greater due to anticipated surge in soft-tissue allografts. Increasing demand for ... The demineralized allografts market can be segmented based on product type, end-users and geography. Based on key product types ... The demineralized allograft market is expected to grow at huge CAGR because of new technological innovations in grafting, and ...
... Guest Editors: Qiquan Sun, Akinlolu O. Ojo, and Xian C. Li *Immunological ... Latent Abnormal Pathology Affects Long-Term Graft Function in Elder Living Renal Allograft Recipients, Linlin Ma, Lei Zhang, Yu ... Molecular Profiling of Acute and Chronic Rejections of Renal Allografts, Hřibová Petra, Honsová Eva, Brabcová Irena, Hrubá ... Aspect on Late Allograft Dysfunction, Qiquan Sun, Akinlolu O. Ojo, and Xian C. Li Volume 2014 (2014), Article ID 625031, 2 ...
Re: Blue Cross denies Ankle Allograft - may need fusion. What was the allograft going to be for? I have BC/BS and they at first ... Re: Blue Cross denies Ankle Allograft - may need fusion. Hey there,. Allograft uses a donor bone to put in the ocd area. An ... THere was someone on this board that had an allograft and the insurance paid everything Except for the actually allograft, in ... Ankle Allograft VS fusion. I have been on a long journey reading these posts and also finding how to treat my end-stage ankle ...
Is the unlisted code appropriate? Does the allograft fall under the description of internal fixation?. Ive been all over the ...
... differential diagnosis of chronic allograft injury and elimination of chronic allograft nephropathy ("CAN")," The American ... Molecular Profiling of Acute and Chronic Rejections of Renal Allografts. Hřibová Petra,1 Honsová Eva,2 Brabcová Irena,1 Hrubá ... L. C. Racusen, K. Solez, R. B. Colvin et al., "The Banff 97 working classification of renal allograft pathology," Kidney ... K. Solez, R. B. Colvin, L. C. Racusen et al., "Banff 07 classification of renal allograft pathology: updates and future ...
Nerve allografts are prepared from donated human nerve tissue. An allograft contains many of the beneficial characteristics of ... Currently the only FDA approved nerve allograft is the Avance graft of AxoGen. A nerve allograft is used for the reconstruction ... Hence, allograft treatment does not seem to be a risk factor for this specific problem. Golden standard therapy for transected ... It has been shown that in allograft surgeries, post-operative neuropathic pain was present in some patients, but only if they ...
Make research projects and school reports about allograft easy with credible articles from our FREE, online encyclopedia and ... allograft A graft of tissue from a donor of one genotype to a host of a different genotype but of the same species. If the ... allograft (homograft) A graft of tissue from a donor of one genotype to a host of a different genotype but of the same species ... allograft (al-oh-grahft) n. a living tissue or organ graft between two members of the same species. Unless the graft is from an ...
The allograft is prepared by treating a section of cadaver bone to remove all soft tissue, then texturing the bone surface to ... The allograft is prepared by treating a section of cadaver bone to remove all soft tissue, then texturing the bone surface to ... The allograft is prepared by treating a section of cadaver bone to remove all soft tissue, then texturing the bone surface to ... Multipiece allograft implant. US7232455. May 26, 2004. Jun 19, 2007. Depuy Mitek, Inc.. Wedge shaped suture anchor and method ...
... NEW ORLEANS, LA ... Osteochondral allograft transplantation (OCA) is a valuable and successful approach for this condition, as described by ... Osteochondral allograft transplantation (OCA) is a valuable and successful approach for this condition, as described by ... as defined by removal or revision of the allograft. ...
One of our surgeons did a nerve repair using an allograft nerve and I cannot find a repair code that corresponds with this ... 64910 states repair with synthetic conduit or vein allograft, but it was a nerve allograft, not a vein allograft. I am ... One of our surgeons did a nerve repair using an allograft nerve and I cannot find a repair code that corresponds with this ...
... whose patients received fresh frozen bone allografts. It also supports the hypothesis that immune responses to allograft ... Coating of the Allograft Substrate with a Polymer Foam. The surface of the cured material or graft substrate may be roughened ... The allograft substrate material may also, suitably, be a molded bioerodible polymer, such as poly(lactide-co-glycolide) X:Y ( ... However, bone allografts are an excellent antigenic source and are capable of stimulating an immune response in the host. ...
Cardiac allograft vasculopathy (CAV) is a common accelerated type of coronary artery disease in people who have had a heart ... Cardiac allograft vasculopathy is an accelerated type of coronary artery disease in people who have had a heart transplantation ... Antibody-mediated cardiac allograft rejection (AMR) is a significant factor leading to the rapid progression of CAV. Future ... Hence, regular follow-up and monitoring of the allograft for early signs of disease is advocated. Surveillance is performed by ...
Since the torque applied to a screw induces shear stresses, the design of a screw made of allograft bone tissue must be as ... A bone screw constructed of allograft bone comprising: a shank with a portion provided with a thread of a given pitch running ... Thus the present screw design is both easy to use and offers the ideal physiological response of patient tissue to allograft ... Such an increase in torsional loading strength is of great importance in allograft bone screws. It should be noted that no ...
Despite aggressive immunosuppression, acute rejection of the lung allograft occurs in over half of transplant recipients, and ... in mouse orthotopic allografts undergoing rejection. We found that stimulation of lymphangiogenesis with VEGF-C156S, a mutant ... and data that directly address the exact roles of lymphatic vessels in lung allograft function and survival are limited. Here, ... alleviates an established rejection response and improves clearance of HA from the lung allograft. Longitudinal analysis of ...
What are vascular composite allografts (VCAs)?. Vascular composite allografts (VCAs) involve the transplantation of multiple ...
Regenerative medicine company R3 Stem Cell is now offering amniotic membrane allograft for eye care treatment. ... R3 offers the amniotic allograft membrane products in four spherical sizes. Call us at (844) GET-STEM.. ... Regenerative medicine company R3 Stem Cell is now offering amniotic membrane allograft for eye care treatment. The membranes ... Regenerative medicine company R3 Stem Cell is now offering amniotic membrane allograft for eye care treatment. The membranes ...
Use of allograft tendons for primary and revision repair has gained greater acceptance among surgeons. The use of allografts ... Arthrex Meniscal Allograft Arthroplasty for Treatment of CMC Arthritis of the Thumb ...
MOPS allografts had a revision rate of only 2%, while the SOC allograft revision rate was 11.5%1. Additionally, MOPS allografts ... MOPS allografts maintained 98.8% viable cell density at 40 to 55 days, compared to Standard of Care (SOC) allografts, which ... Osteochondral Allografts Product Overview. Available exclusively from CONMED through MTF Biologics, osteochondral allografts ... MOPS allografts maintained 98.8% viable cell density at 40 to 55 days1 - giving surgeons and their patients significantly more ...
Allograft is routinely used to fill the space created from correcting the mechanical axis since autografts add extra time to ...
The use of allografts reduces OR time and eliminates the risk of donor site morbidity. ... Use of allograft tendons for primary and revision ACL and PCL repair has gained greater acceptance among surgeons. ... The use of allografts reduces OR time and eliminates the risk of donor site morbidity. Other uses of allograft tendons are for ... Use of allograft tendons for primary and revision ACL and PCL repair has gained greater acceptance among surgeons. ...
  • CHICAGO -- Extended criteria for liver donor allografts , including the use of living donors, increase access to liver transplantation and significantly reduce wait-list mortality while providing satisfactory outcomes, according to researchers at New York-Presbyterian Hospital. (thefreedictionary.com)
  • In 2002, approximately one million allografts were distributed for transplantation (American Association of Tissue Banks [AATB], unpublished data, 2002). (thefreedictionary.com)
  • This topic reviews the epidemiology, clinical presentation, diagnosis, treatment, and prognosis of acute rejection of the pancreas allograft in the setting of SPK transplantation. (uptodate.com)
  • Meniscal allograft transplantation is surgery in which a meniscus -- a c-shaped cartilage in the knee -- is placed into your knee. (medlineplus.gov)
  • Nerve regeneration, is described for the first time in 1795 and in 1885 the first nerve allograft transplantation was reported. (wikipedia.org)
  • Demineralized allografts if not combined with other materials then only it can be utilized for transplantation. (sbwire.com)
  • Cardiac allograft vasculopathy (CAV) is a common accelerated type of coronary artery disease in people who have had a heart transplantation. (wikipedia.org)
  • Banff 07 classification of renal allograft pathology: updates and future directions," The American Journal of Transplantation , vol. 8, no. 4, pp. 753-760, 2008. (hindawi.com)
  • Banff '05 meeting report: differential diagnosis of chronic allograft injury and elimination of chronic allograft nephropathy ("CAN")," The American Journal of Transplantation , vol. 7, no. 3, pp. 518-526, 2007. (hindawi.com)
  • Osteochondral allograft transplantation (OCA) is a valuable and successful approach for this condition, as described by research presented today at the American Orthopaedic Society for Sports Medicine's Specialty Day in New Orleans. (prweb.com)
  • Vascular composite allografts (VCAs) involve the transplantation of multiple structures that may include skin, bone, muscles, blood vessels, nerves and connective tissue. (transplantliving.org)
  • Chondrocyte Viability at Time of Transplantation for Osteochondral Allografts Preserved by the Missouri Osteochondral Preservation System versus Standard Tissue Bank Protocol. (conmed.com)
  • Meniscal allograft transplantation for symptomatic knee after men. (ingentaconnect.com)
  • Meniscal allograft transplantation in complicated discoid medial meniscus was performed. (ingentaconnect.com)
  • At 2 years after meniscal allograft transplantation, clinical outcomes were improved with a normal range of motion. (ingentaconnect.com)
  • Meniscal allograft transplantation may be an alternative option in highly active young patients undergoing complicated discoid medial meniscus to diminish pain, improve knee function, and prevent or delay degeneration. (ingentaconnect.com)
  • BACKGROUND: Fresh osteochondral allograft transplantation is an increasingly common treatment option for chondral and osteochondral lesions in the knee, but the long-term outcome is unknown. (biomedsearch.com)
  • METHODS: We evaluated 122 patients (129 knees) who underwent osteochondral allograft transplantation of the femoral condyle. (biomedsearch.com)
  • Examines the efficacy of cyclosporin A in prolonging normoglycemia and graft survival after whole-organ pancreas allograft transplantation. (ebscohost.com)
  • The U.S. Department of Health and Human Services (DHHS) has issued a proposed rule to include vascularized composite allografts (VCA) within the definition of organs under the authority of the Organ Procurement and Transplantation Network (OPTN). (unos.org)
  • After transplantation of organ allografts, there are two pathways of antigen presentation. (genome.jp)
  • Larger defects are typically treated with autologous chondrocyte transplantation, osteochondral allograft transplantation, or newer synthetic or natural scaffolds which may require open incisions. (cartilage.org)
  • We are committed to providing the highest quality bone and tissue allograft products - as well as continued innovation in the development of allograft implants for transplantation. (mountsinai.on.ca)
  • Cardiac allograft vasculopathy remains a leading cause of morbidity and mortality after transplantation. (bioportfolio.com)
  • Life expectancy of patients who lose cardiac allografts is dramatically poor due to the absence of any therapeutic tool apart from re-transplantation, which is plagued by poor outcomes. (clinicaltrials.gov)
  • indeed CAV occurs in 50% of HT recipients by 5 years after transplantation and invariably results in allograft failure. (clinicaltrials.gov)
  • Heart transplantation is a lifesaving procedure however, more then 20% of patients do not survive beyond 3 years, being the cardiac allograft afflicted by cardiac allograft vasculopathy (CAV), which results in allograft loss. (clinicaltrials.gov)
  • Mankin HJ, Doppelt SH, Sullevan TR, Tomford WW: Osteoarticular and intercalary allograft transplantation in the management of malignant tumors of bone. (medigraphic.com)
  • We determined whether early recognition of subclinical rejection has long-term consequences for kidney allograft survival in an observational prospective cohort study of 1307 consecutive nonselected patients who underwent ABO-compatible, complement-dependent cytotoxicity-negative crossmatch kidney transplantation in Paris (2000-2010). (unboundmedicine.com)
  • This video demonstrates our technique for osteochondral allograft transplantation for the management of articular cartilage defects of the knee. (aaos.org)
  • The video reviews the indications and contraindications for, patient positioning for, surgical technique for, outcomes of, and postoperative management for osteoarticular allograft transplantation. (aaos.org)
  • First, it might ultimately be possible to take advantage of the toleragenic system utilized during mammalian gestation to promote the survival of other types of allograft: an outcome that would have important ramifications in transplantation medicine. (labome.org)
  • Cardiac allograft vasculopathy (CAV) is a major cause of long-term morbidity and mortality after successful heart transplantation and represents the leading cause of mortality in transplant recipients who survive more than 1 year. (ahajournals.org)
  • Approximately ninety percent of the protocol biopsies of renal allografts, performed at 18 months post transplantation, show histological lesions of chronic calcineurin nephrotoxicity. (clinicaltrials.gov)
  • International Society for Heart and Lung Transplantation working formulation of a standardized nomenclature for cardiac allograft vasculopathy-2010. (springer.com)
  • Unilateral Versus Bilateral Lung Transplantation: Do Different Esophageal Risk Factors Predict Chronic Allograft Failure? (bioportfolio.com)
  • Current opinion in meniscal allograft transplantation. (scielo.org.za)
  • The viability of articular cartilage in fresh osteochondral allografts after clinical transplantation. (scielo.org.za)
  • Chronic lung allograft dysfunction (CLAD) is, in one sense, a term without a true consensus definition, although its common usage in the field of lung transplantation implies a base understanding throughout the community that it describes a lung allograft that does not work (well) [ 1 ]. (ersjournals.com)
  • However, pancreas allograft rejection remains a major clinical challenge and is the primary cause of death-censored pancreas allograft loss after three months posttransplant. (uptodate.com)
  • However, this discussion is also applicable to pancreas allograft rejection in PAK and PTA recipients. (uptodate.com)
  • An immune response against an allograft or xenograft is called transplant rejection. (wikipedia.org)
  • Molecular heterogeneity in acute renal allograft rejection identified by DNA microarray profiling," The New England Journal of Medicine , vol. 349, no. 2, pp. 125-138, 2003. (hindawi.com)
  • Despite aggressive immunosuppression, acute rejection of the lung allograft occurs in over half of transplant recipients, and the factors that promote lung acceptance are poorly understood. (jci.org)
  • Here, we have shown that there is a marked decline in the density of lymphatic vessels, accompanied by accumulation of low-MW hyaluronan (HA) in mouse orthotopic allografts undergoing rejection. (jci.org)
  • We found that stimulation of lymphangiogenesis with VEGF-C156S, a mutant form of VEGF-C with selective VEGFR-3 binding, alleviates an established rejection response and improves clearance of HA from the lung allograft. (jci.org)
  • Buttemeyer R, Jones NF, Min Z et al (1996) Rejection of the component tissues of limb allografts in rats immunosuppressed with FK-506 and cyclosporine. (springer.com)
  • These colonizing T cells can be shown to contain members with regulatory function, as they can prevent nontolerant lymphocytes from rejecting fresh skin allografts, without hindrance of rejection of third party skin. (rupress.org)
  • Experimental evidence suggests that PAF plays a role in the pathogenesis of a variety of inflammatory processes including allograft rejection. (ebscohost.com)
  • Allograft rejection is the consequence of the recipient's alloimmune response to nonself antigens expressed by donor tissues. (genome.jp)
  • Rejected MHC-mismatched cardiac allografts in CCR5 −/− recipients have low T cell infiltration, but intense deposition of C3d in the large vessels and capillaries of the graft, characteristics of Ab-mediated rejection. (jimmunol.org)
  • Day 8 posttransplant serum titers of donor-specific Ab were 15- to 25-fold higher in CCR5 −/− allograft recipients, and transfer of this serum provoked cardiac allograft rejection in RAG-1 −/− recipients within 14 days, whereas transfer of either serum from wild-type recipients or immune serum from CCR5-deficient recipients diluted to titers observed in wild-type recipients did not mediate this rejection. (jimmunol.org)
  • These results indicate that the donor-specific Ab produced in CCR5 −/− heart allograft recipients is sufficient to directly mediate graft rejection, and the absence of recipient CCR5 expression has differential effects on the priming of alloreactive CD4 and CD8 T cells. (jimmunol.org)
  • T cell-mediated rejection of allografts is initiated by the infiltration and activation of donor Ag-specific effector T cells in the graft. (jimmunol.org)
  • We observed that almost all mice receiving allografts of XIAP-expressing islets maintained normoglycemia until the experiment was terminated (45-72 days posttransplant), whereas control mice receiving islets transduced with adenovirus expressing LacZ were hyperglycemic by ∼17 days posttransplantation due to graft rejection. (diabetesjournals.org)
  • However, it has also been shown that the Fas and perforin pathways alone or in combination are not required for islet allograft rejection, suggesting that other pathways may play more crucial roles ( 5 ). (diabetesjournals.org)
  • In islet transplants, the death of β-cells is caused not only by immune rejection of the allograft, but also by trauma to β-cells during islet isolation, culture, and graft revascularization ( 7 , 8 ). (diabetesjournals.org)
  • Kidney allograft rejection can occur in clinically stable patients, but long-term significance is unknown. (unboundmedicine.com)
  • A 10-day course with ART-18, a mouse monoclonal antibody (mAb) directed against the rat interleukin 2 receptor (IL-2R), prolongs the survival of (LEW x BN)F1 cardiac allografts in LEW recipients to approximately 3 weeks (acute rejection = 8 days, P less than 0.001). (pnas.org)
  • Characterization of intra-graft B cells during renal allograft rejection. (wikipathways.org)
  • Rejection of the kidney allograft. (wikipathways.org)
  • Significance and suppression of redundant IL17 responses in acute allograft rejection by bioinformatics based drug repositioning of fenofibrate. (wikipathways.org)
  • We sought to determine the role of CCR5 in islet allograft rejection in a streptozotocin-induced diabetic mouse model. (diabetesjournals.org)
  • We conclude that CCR5 plays an important role in orchestrating the Th1 immune response leading to islet allograft rejection. (diabetesjournals.org)
  • Targeting this chemokine receptor, therefore, may provide a clinically useful strategy to prevent islet allograft rejection. (diabetesjournals.org)
  • Through activation of the G-protein-coupled cell-surface receptor on target cells, chemokines and their receptors play a major role in the process by which leukocytes are recruited from the bloodstream into sites of inflammation, and several have been implicated in allograft rejection ( 1 ). (diabetesjournals.org)
  • Met-RANTES, a CCR5 antagonist, can reduce the severity of chronic renal allograft rejection in the Lewis→Fisher model. (diabetesjournals.org)
  • We have recently shown that susceptibility of human renal allograft recipients to acute rejection episodes is influenced by their CCR5 and CCR2 receptor genotypes ( 10 ). (diabetesjournals.org)
  • We now provide evidence that CCR5 plays an important role in mediating islet allograft rejection and that the blockade of CCR5 would be of value in achieving long-term islet allograft survival. (diabetesjournals.org)
  • Nevertheless, temporary immunosuppression produced lower NCV when allografts were used, with less maturation of the myelinated fibers, which indicated that a partial rejection had taken place. (cun.es)
  • Recent reports suggest that complement system contributes to allograft rejection. (nature.com)
  • Herein, we investigate the role of complement component 3 (C3) in a single MHC-II molecule mismatched murine model of allograft rejection using C3 deficient mice (C3 −/− ) as skin graft donors or recipients. (nature.com)
  • Compared with C3 +/+ B6 allografts, C3 −/− B6 grafts dramatically prolonged survival in MHC-II molecule mismatched H-2 bm12 B6 recipients, indicating that C3 plays a critical role in allograft rejection. (nature.com)
  • The role of C3 in allograft rejection remains controversial. (nature.com)
  • The primary alloantigen-dependent event associated with CAN is acute rejection, which is a strong risk factor for development of CAN and accelerated allograft loss [4]. (uninet.edu)
  • 3. Tullius SG, Tilney NL: Both alloantigen-dependent and independent factors influence chronic allograft rejection. (uninet.edu)
  • The aim of this study is to verify the ability of transglutaminase type 2 to predict rejection or chronic allograft nephropathy of renal allograft. (bioportfolio.com)
  • Standardised 3×60 ml surveillance BAL fluid samples from 13 chronologically sequential stable lung allograft recipients without chronic rejection (10 patients treated with a prophylactic proton pump inhibitor) were studied. (bmj.com)
  • The AlloSure test is intended to assess the probability of allograft rejection in kidney transplant recipients with clinical suspicion of rejection and to inform clinical decision-making regarding the necessity of renal biopsy in such patients at least 2 weeks post-transplant in conjunction with standard clinical assessment. (mayo.edu)
  • Cell-Free DNA and Active Rejection in Kidney Allografts. (mayo.edu)
  • Histologic analysis of the allograft biopsy specimen is the standard method used to differentiate rejection from other injury in kidney transplants. (mayo.edu)
  • Currently the only FDA approved nerve allograft is the Avance graft of AxoGen. (wikipedia.org)
  • allograft ( homograft ) A graft of tissue from a donor of one genotype to a host of a different genotype but of the same species. (encyclopedia.com)
  • allograft ( al -oh-grahft) n. a living tissue or organ graft between two members of the same species. (encyclopedia.com)
  • Due to the nature of this very desirable tissue and limited availability, MTF Biologics offers graft matching services specifically designed to provide orthopedic surgeons with the best possible anatomically matched allografts to meet each individual patient's unique needs. (conmed.com)
  • Poor experiences with these nontissue substitutes led surgeons to choose other graft materials, including allografts. (medscape.com)
  • In addition, depending on where the surgery is done, structural allograft may not be as readily available as synthetic cages and bone graft extenders. (spineuniverse.com)
  • The age of an allograft, the age of the donor and whether or not the graft was irradiated had no clinically relevant effects on the bioavailability of growth factors for an allograft fusion, according to study data. (healio.com)
  • Renal allograft thrombosis is the leading cause of graft failure in pediatric transplant recipients in the early post-transplant period. (eurekaselect.com)
  • Three different type of graft exist depending on their sources .Those include xenografs, autografts and allografts. (openwetware.org)
  • Fibroblast penetration in the site of graft is very important for tissue healing in the sense that it promote acellurization.Autograft and Allograft promote more infiltration of fibroblast compare to xenograth. (openwetware.org)
  • Ahn JH, Yoo JC, Wang JH (2005) Posterior cruciate ligament reconstruction: double-loop hamstring tendon autograft versus Achilles tendon allograft-clinical results of a minimum 2-year follow-up. (springer.com)
  • Bullis DW, Paulos LE (1994) Reconstruction of the posterior cruciate ligament with allograft. (springer.com)
  • Fanelli GC, Beck JD, Edson CJ (2012) Single compared to double-bundle PCL reconstruction using allograft tissue. (springer.com)
  • A nerve allograft is used for the reconstruction of peripheral nerve discontinuities in order to support the axonal regeneration across a nerve gap caused by any injury. (wikipedia.org)
  • Growth drivers of demineralized allografts market in the near future include increase in the volume of procedures like spinal fusion, and joint reconstruction because of rising number of pandemics, rapidly aging population and increasing obesity rates. (sbwire.com)
  • Reconstruction of Corneal Epithelium by Limbal Allograft Tra. (lww.com)
  • Parametrics Medical has succeeded at providing the most current technologies in allograft bone and soft tissue processing spanning all specialties within orthopedics to include sports medicine, trauma, joint reconstruction and spine. (biospace.com)
  • A prospective study was performed on 30 patients who underwent an anterior cruciate ligament reconstruction with fresh-frozen patellar tendon allograft. (cun.es)
  • Fresh-frozen patellar tendon allografts are a good method of anterior cruciate reconstruction. (cun.es)
  • The preliminary results confirmed our hypothesis and demonstrated that the PE-R tendon allograft has significant potential as an alternative to ligament/tendon reconstruction. (sigmaaldrich.com)
  • Tendon allografts have been extensively used in ligament reconstruction and tendon repair. (sigmaaldrich.com)
  • This study suggests that PE-R tendon allograft has great potential as an alternative for ligament/tendon reconstruction. (sigmaaldrich.com)
  • 4].They are defined as decelluralize extracellular matrix made of laminin, fibronectin,elastin and collagen.Among their application, we can illustrate skin replacement,Hernia repair,breast reconstruction,tendon repair and genealogical reconstruction.The most common biological scaffold are Autograft,Xenograft and Allograft. (openwetware.org)
  • Traditionally, intercalary allograft reconstruction after tumor resection has had a high rate of complications, particularly nonunion. (healio.com)
  • When joint preservation is possible, intercalary allograft reconstruction is an option, but it is not without complications. (healio.com)
  • 5. Roberts TS, Drez D, McCarthy W, Paine R. Anterior cruciate ligament reconstruction using freeze-dried, ethylene oxide-sterilized, bone-patellar tendon-bone allografts: two year results in thirty-six patients. (scielo.org.za)
  • Bone allograft in limb reconstruction. (scielo.org.za)
  • Allograft versus autograft anterior cruciate ligament reconstruction: 3- to 5-year outcome. (scielo.org.za)
  • Reconstruction of the anterior cruciate ligament with human allograft: comparison of early and later results. (scielo.org.za)
  • Allografts for ligamentous reconstruction of the knee. (scielo.org.za)
  • To review post-transplant outcomes and patient survival in HCV-negative recipients receiving solid organ transplants (SOT) from viraemic, that is, HCV+/NAT+ (nucleic acid testing) allografts. (medscape.com)
  • The contribution of lymphatic vessels to transplant pathophysiology remains controversial, and data that directly address the exact roles of lymphatic vessels in lung allograft function and survival are limited. (jci.org)
  • Inceoglu S, Siemionow M, Chick L et al (1994) The effect of combined immunosuppression with systemic low-dose cyclosporin and topical fluocinolone acetonide on the survival of rat hind-limb allografts. (springer.com)
  • Prolongation of canine pancreas allograft survival with cyclosporin A: preliminary report. (ebscohost.com)
  • With improved immunosuppression and early allograft survival, chronic allograft nephropathy has become the dominant cause of kidney-transplant failure. (nih.gov)
  • Long-term protection of islet allografts by XIAP overexpression may enhance the survival of islet transplants in diabetes. (diabetesjournals.org)
  • ATP/P2X7R signaling in T cells is highly relevant for cardiac allograft survival. (clinicaltrials.gov)
  • We have recently demonstrated that the ATP/P2X7R axis has a key role in cardiac allograft survival in humans and mice. (clinicaltrials.gov)
  • It has recently been demonstrated that targeting CCR5 prolongs vascularized cardiac allograft survival in a mouse transplant model ( 8 ). (diabetesjournals.org)
  • Our results indicate for the first time that C3 deficiency can prolong MHC-II molecule mismatched skin allograft survival, which is further confirmed to be associated with increased CD4 + CD25 + Treg cell population expansion and attenuated Th1/Th17 response. (nature.com)
  • It was indicated that intra-renal C3 deficiency (C3 −/− ) prolonged renal allograft survival and caused a defective alloreactive T cell response when compared with C3 positive (C3 +/+ ) allografts 18 . (nature.com)
  • Despite major improvements in short term allograft survival rates, CAN continues to limit transplant survival in a large portion of this population [1,2]. (uninet.edu)
  • Allo-HCT can cure AML, depending on the remission status at the time of the allograft, with overall survival (OS) rates of between 15% and 30% in relapsed/refractory disease and between 50% and 75% in patients who receive allografts during the initial complete remission (CR). (cancernetwork.com)
  • Preliminary data suggest that angiotensin converting enzyme inhibitors retard the atherosclerotic plaque development that is the hallmark of cardiac allograft vasculopathy. (bioportfolio.com)
  • Moreover, this class of drug appears to increase circulating endothelial progenitor cell number and has anti-inflammatory properties, both of which improve endothelial dysfunction, the key precursor to the development of cardiac allograft vasculopathy. (bioportfolio.com)
  • The objective of this project is to investigate the role of an angiotensin converting enzyme inhibitor, ramipril, in preventing the development of cardiac allograft vasculopathy. (bioportfolio.com)
  • The primary endpoint will be the development of cardiac allograft vasculopathy based on intravascular ultrasound-derived parameters. (bioportfolio.com)
  • Background - Coronary endothelial dysfunction may be an early marker for cardiac allograft vasculopathy (CAV) in orthotopic heart transplant recipients. (ahajournals.org)
  • HealthDay)-Noninvasive coronary computed tomography angiography (CCTA) is a reliable alternative to coronary angiography for detection of cardiac allograft vasculopathy (CAV), according to a meta-analysis published online March 26 in the Journal of the American College of Cardiology . (medicalxpress.com)
  • Available exclusively from CONMED through MTF Biologics, osteochondral allografts with the Missouri Osteochondral Allograft Preservation System (MOPS℠) provide nearly double the storage-life with increased viable chondrocyte density. (conmed.com)
  • Meanwhile studies show that mean chondrocyte viability in osteochondral allografts stored using the current standard tissue bank protocols progressively declines and falls below the minimum essential level by 28 days from the time of procurement. (conmed.com)
  • Importance of Donor Chondrocyte Viability for Osteochondral Allografts. (conmed.com)
  • Do fresh osteochondral allografts successfully treat femoral condyle lesions? (biomedsearch.com)
  • Massive osteochondral allografts in the management of nontumoral conditions around the knee. (scielo.org.za)
  • The effects of storage on fresh human osteochondral allografts. (scielo.org.za)
  • Fresh osteochondral allografts for post-traumatic osteochondral defects ofthe knee. (scielo.org.za)
  • Blood cyclosporin concentrations and renal allograft dysfunction. (ebscohost.com)
  • Renal allograft biopsy plays a crucial role in the diagnosis and management of renal allograft dysfunction in renal transplant recipients. (omicsonline.org)
  • The controls were renal transplant patients who received their allograft during the same period as the cases with stable renal function and no need for a transplant biopsy for allograft dysfunction. (uninet.edu)
  • A biologically plausible link between gastro-oesophageal reflux (GOR), aspiration, and lung allograft dysfunction has been suggested, but there is no systematic evidence indicating the presence of gastric contents in the lung. (bmj.com)
  • The relationship between bronchopulmonary Pseudomonas aeruginosa and chronic lung allograft dysfunction (CLAD) has often stimulated considerations of primacy. (ersjournals.com)
  • Physiology of chronic lung allograft dysfunction: back to the future? (ersjournals.com)
  • In particular, composite allografts consisting of cortical side plates for strength and a cancellous core for enhanced fusion have been successfully used in ACDF cases [1, 3]. (thefreedictionary.com)
  • 7. A sterile malleable bone composition as claimed in claim 1 wherein said bone powder is cortical allograft bone powder. (google.de)
  • Development of a minimally invasive, longitudinal outcome measure to quantify intramedullary vascular volume and cortical bone volume of structural allografts in patients is required to translate 'revitalizing' structural allograft in clinical trials. (clinicaltrials.gov)
  • Given the success of direct-acting antivirals (DAAs) in treating hepatitis C (HCV), interest is growing in utilizing solid organs from allografts with active HCV to expand donor availability. (medscape.com)
  • Allografts comprise the tissues, cells and/or proteins that are utilized for implantation, infusion or transplant from donor to the recipient with different genetic makeup of the same species. (sbwire.com)
  • Inflammation and endothelial injury can be triggered by the donor arrest, organ procurement, and allograft ischaemia and reperfusion. (wikipedia.org)
  • The use of allografts reduces OR time and eliminates the risk of donor site morbidity. (arthrex.com)
  • Allograft is routinely used to fill the space created from correcting the mechanical axis since autografts add extra time to the procedure and donor site morbidity to the patient. (conmed.com)
  • Untreated allografts (using a nerve from a donor) have also been used. (nice.org.uk)
  • Wild-type C57BL/6 and B6.CCR5 −/− (H-2 b ) recipients of A/J (H-2 a ) cardiac allografts had equivalent numbers of donor-reactive CD4 T cells producing IFN-γ, whereas CD4 T cells producing IL-4 were increased in CCR5 −/− recipients. (jimmunol.org)
  • CD8+ stimulated T cells lead to apoptosis of the allograft donor cells whereas CD4+ T cells differentiate into TH1, TH2, T17, and Treg cells. (wikipathways.org)
  • Their differ from the allografts in which case the donor and the host are from the same species( human to human).In autograft,The recipient is consider as the source in which case a tissue is transplanted from one part of the body to another.An example is the ligament repair in which case the most common harvest sites are the patellar tendon,hamstring tendon and quadriceps tendon of the patient. (openwetware.org)
  • With post-allograft-relapsed AML, the calculus to administer either allo-HCT2 or DLI is multifactorial and includes donor availability, remission status, presence of disabling comorbidities, and the center or physician preference. (cancernetwork.com)
  • An abstract of the article "Thrombotic microangiopathy in renal allografts," by S. Radha and colleagues is presented. (ebscohost.com)
  • Curran AR, Adams DJ, Gill JL, Steiner ME, Scheller AD (2004) The biomechanical effects of low-dose irradiation on bone-patellar tendon-bone allografts. (springer.com)
  • Effects of gamma irradiation on the initial mechanical and material properties of goat bone-patellar tendon-bone allografts. (scielo.org.za)
  • Renal mass as a determinant of late allograft outcome: Insights from experimental studies in rats. (ebscohost.com)
  • Schema of the potential sites of injury associated with late allograft failure. (asnjournals.org)
  • Trafficking of T cells and other leukocytes to inflammation in peripheral tissues including allografts is directed in part by leukocyte expression of chemokine receptors responsive to chemokines produced at the inflammatory site ( 16 , 17 ). (jimmunol.org)
  • Health-care facilities and surgeons can order allograft tissues from Mount Sinai Allograft Technologies. (mountsinai.on.ca)
  • The most common applications are bone and ligament allografts, but other tissues are also available for grafting. (scielo.org.za)
  • This means the nerve allograft only consists of extracellular matrix (ECM), which is sterile and decullularized. (wikipedia.org)
  • 64910 states repair with synthetic conduit or vein allograft, but it was a nerve allograft, not a vein allograft. (aapc.com)
  • Kidney Allograft Failure in the Steroid-Free Immunosuppression Era: A Matched Case-Control Study. (bioportfolio.com)
  • We studied the causes and predictors of death-censored kidney allograft failure among 1670 kidney recipients transplanted at our center in the corticosteroid-free maintenance immunosuppression era. (bioportfolio.com)
  • R3 is proud to offer the Vendaje collection of placental tissue allograft membrane products. (prweb.com)
  • Yet, the maternal immune system remains competent to repel infection or to reject other forms of tissue allograft. (labome.org)
  • TY - JOUR T1 - Dermal tissue allograft for the repair of massive irreparable rotator cuff tears. (unboundmedicine.com)
  • Early pancreas allograft thrombosis. (nih.gov)
  • Long-term published clinical studies comparing allografts with autografts are not numerous. (medscape.com)
  • The purpose of this study is to investigate quantitative vascular cone beam CT(CBCT) in a clinical pilot of patients that have received a structural allograft for bone cancer or a vascularized structural autograft for bone cancer or traumatic injury. (clinicaltrials.gov)
  • These data will be used to devise a power calculation for a definitive clinical trial to evaluate the efficacy of the revitalizing allograft. (clinicaltrials.gov)
  • A retrospective, observational, longitudinal study was conducted to obtain clinical and radiologic data of the sample composed of a group of 15 patients with a diagnosis of limb osteosarcoma treated at our hospital with structural bone allografts. (medigraphic.com)
  • developing and marketing regenerative and therapeutic biologics utilizing human placental tissue allografts and patent-protected processes for multiple sectors of healthcare, announced today that the latest peer-reviewed scientific and clinical review article of the MiMedx dehydrated human amnion/chorion membrane ("dHACM") allografts has been electronically published in the journal Techniques In Orthopaedics . (medindia.net)
  • dHACM allografts have been shown in randomized clinical trials to be effective therapies to enhance healing, and have demonstrated the ability to recruit the migration of stem cells to the site of injury in vitro and in vivo . (medindia.net)
  • More recently, talented investigators, including Drs. Yankah, Yacoub, and others, have been developing information concerning the immunological aspects of the use of allografts, as well as their clinical use. (worldcat.org)
  • Research and clinical applications have demonstrated that the effects of tendon allografts are comparable to those of autografts when reconstructing injured tendons or ligaments, but allograft safety remains problematic. (sigmaaldrich.com)
  • The clinical use of nerve allografts combined with immunosuppressant therapy has become a genuine possibility that could supersede the classic use of autografts. (cun.es)
  • Despite a high clinical suspicion regarding GOR in lung allografts, the literature is small and largely retrospective. (bmj.com)
  • Management of peripheral vascular problems in recipients of cardiac allografts. (biomedsearch.com)
  • Pretreatment with cyclosporine and anti-interleukin 2 receptor antibody abrogates the anti-idiotype response in rat recipients of cardiac allografts. (pnas.org)
  • Qyresearchreports include new market research report Global Demineralized Allografts Market Research Report 2017 to its huge collection of research reports. (openpr.com)
  • This report on the global Demineralized Allografts market has been developed by a selected group of professional market research analysts, with a solitary goal to present the existing scenario of the market for Demineralized Allografts and shed light on its growth prospects. (openpr.com)
  • The report presents extensive assessment of the crucial factors that may influence the demand in the global Demineralized Allografts market, studies the challenges or pitfalls, and make a note of the latest trends, which the existing players must take into consideration in order to keep up in the market competition. (openpr.com)
  • The segmentation of the global demineralized allografts market based on geography include regions such as North America, Europe, Asia Pacific, Latin America, and the Middle East & Africa. (sbwire.com)
  • Thirty-five studies were included (or 852 SOTs): 343 kidney, 233 heart, 204 liver, and 72 lung transplants from viraemic allografts. (medscape.com)
  • The literature on HCV viraemic allograft transplants to negative recipients emphasizes the excellent safety profile of such transplants. (medscape.com)
  • We evaluated the natural history of chronic allograft nephropathy in a prospective study of 120 recipients with type 1 diabetes, all but 1 of whom had received kidney-pancreas transplants. (nih.gov)
  • 24. Morag G, Kulijian A, Zalal P. Total knee replacement in previous recipients of fresh osteochondral allograft transplants. (scielo.org.za)
  • AlloSource, Centennial, CO, one of the nation's largest non-profit providers of skin, bone and soft tissue allografts for use in surgical procedures, and the world's largest processor of cellular bone allografts , has been awarded a patent for its proprietary tissue cleaning and disinfecting system called AlloTrue. (thefreedictionary.com)
  • Growth in demineralized allograft market is greater due to anticipated surge in soft-tissue allografts. (sbwire.com)
  • About AlloSource AlloSource is one of the largest nonprofit cellular and tissue networks in the country, offering more than 200 types of precise cartilage, cellular, bone, skin and soft-tissue allografts to advance patient healing. (medindia.net)
  • ROUND ROCK, Texas , May 8, 2013 /PRNewswire/ -- Parametrics Medical, LLC, a private tissue bank specializing in providing the most diverse supply of allografts available in the market, announces its release of their Coll-e-Strong line of soft tissue allografts. (biospace.com)
  • Dr. Ehrhart's preclinical study, entitled Adipose-Derived Mesenchymal Stromal Cells Seeded on Demineralized Bone Matrix Persist and Differentiate When Implanted in a Critical-Sized Rat Femur Defect , used similar technology to AlloSource's AlloStem Cellular Bone Allograft proprietary, patented process. (medindia.net)
  • Ortho-biologics company Royal Biologics launched Magnus, a DMSO-free viable cellular bone allograft, the first of its kind to be DMSO-free. (beckersspine.com)
  • Regenerative medicine company R3 Stem Cell is now offering amniotic membrane allograft for eye care treatment. (prweb.com)
  • AlloStem is partially demineralized allograft bone combined with adipose-derived mesenchymal stem cells. (medindia.net)
  • Decelurization also occur with the xenografts after which the scaffold is sterilized instead of being disinfected as is the case for autograft and allograft. (openwetware.org)
  • No statistically significant differences were found in the neuronal and axonal counts between autograft and allograft groups at 8 months. (cun.es)
  • An obvious issue is, What is the better choice when both autografts and allografts are available to the surgeon and patient? (medscape.com)
  • [ 1 , 2 ] (See Treatment for a discussion of the advantages and disadvantages of autografts and allografts. (medscape.com)
  • Xenografts are considered as medical devices while autografts and allografts are viewed as a Human Cell and Tissue/Product by the FDA.In addition, due to the high degree of biocompatibilty, allograft and autograft are not sterilize before implantation compare to xenograft.In addition, the requirement for packaging and storage are set by the tissue bank.The picture below describe an overview of dermal donation process. (openwetware.org)
  • The 2014 guideline on the management of ACL injuries formulated by the American Association of Orthopaedic Surgeons (AAOS) recommended that practitioners use either autograft or appropriately processed allograft tissue in patients undergoing ACL reconstructions, on the grounds that the measured outcomes are similar, though with the caveat that these results may not be generalizable to all allografts or all patients (eg, young or highly active patients). (medscape.com)
  • One study showed improved long-term outcomes with autograft over allograft as well as with not smoking and with normal body mass index. (medscape.com)
  • Dr. Lee and colleagues analyzed outcomes from 6,130 patients who underwent ACDF with structural allograft (n=4,063) or intervertebral cage (n=2,067) and anterior plating between 2007 and 2016 using data from a single nationwide health insurance company. (spineuniverse.com)
  • Parker H. Petit , Chairman and CEO, stated, "The outcomes that physicians have reported they are achieving when utilizing our dHACM allografts in orthopedic procedures are very impressive. (medindia.net)
  • Patients undergoing repair of massive irreparable rotator cuff tears through a mini-open approach with the use of human dermal tissue matrix allograft would demonstrate an improvement in pain, range of motion, strength, and subjective functional outcomes. (unboundmedicine.com)
  • With respect to the primary outcomes, Kharfan-Dabaja et al found no significant difference in OS in post-allograft-relapsed AML patients who then received either allo-HCT2 or DLI at 2 years or 5 years ( P = .86). (cancernetwork.com)
  • Use of allograft tendons for primary and revision repair has gained greater acceptance among surgeons. (arthrex.com)
  • Other uses of allograft tendons are for the medial collateral ligament (MCL), lateral collateral ligament (LCL), elbow ligament repair, and for lateral ankle stabilization procedures. (arthrex.com)
  • This review will cover osteochondral, meniscal and ligament allografts. (scielo.org.za)
  • It may be noted that the interpretation of renal transplant lesions on renal allograft biopsies in earlier Banff schemas was based predominantly on light microscopy (LM) and the tinctorial stains. (omicsonline.org)
  • ASCVD is likely to be an important factor in premature allograft loss in renal transplant patients both by contributing to the pathogenesis of CAN and leading to death from CVD. (uninet.edu)
  • The placental extracellular matrix tissue contains a variety of components that are anti-inflammatory, thereby reducing risk of infection, adhesions and promoting healthy tissue regeneration.The allografts are derived from dehydrated human amniotic tissue and are sterilized post-packaging via ebeam sterilization. (prweb.com)
  • Amniotic membrane allografts are composed of extracellular matrix components such as collagen, fibronectin, and laminin, and contain a vast array of diverse growth factors and cytokines. (medindia.net)
  • MiMedx PURION Processed dHACM (EpiFix and AmnioFix ) allografts have been used in various orthopedic applications, including tendon and ligament repair, treatment of cartilage and joint space disorders, and spine procedures. (medindia.net)
  • Replacement of the anterior cruciate ligament using a patellar tendon allograft: an experimental study. (scielo.org.za)
  • Gross A.E. (1992) Allografts in Total Knee Arthroplasty. (springer.com)
  • In your example, the surgeon implanted the allograft into the joint space as part of an arthroplasty procedure. (hcpro.com)
  • When items such as allografts are used during a surgery such as an arthroplasty, they are considered supplies and are integral to the surgery. (hcpro.com)
  • This case demonstrate the use of fresh frozen femoral head allograft, plate fixation augmented with cerclage in a salvage procedure for failed wrist arthroplasty for rheumatoid arthritis. (eatonhand.com)
  • Multiligament reconstructions require an important quantity of grafts and often determine the need for cadaver allografts during the surgical repair procedures. (springer.com)
  • One barrier to using allograft is that reimbursement for implantation of PEEK devices is per surgical level, while structural allograft can be charged for only once regardless of the number of levels actually performed, Dr. Than noted. (spineuniverse.com)
  • The surgeon has a choice between an allograft, which comes from tissue donors, and an autograft, which is typically a tendon taken from another part of the patient's body and repurposed for the ACL. (biospace.com)
  • Surgeons use allografts from tissue donors on roughly 40% of all ACL procedures. (biospace.com)
  • One of our surgeons did a nerve repair using an allograft nerve and I cannot find a repair code that corresponds with this procedure. (aapc.com)
  • MOPS allografts maintained 98.8% viable cell density at 40 to 55 days 1 - giving surgeons and their patients significantly more time to schedule the surgery. (conmed.com)
  • As the world's largest processor of cellular bone allografts, fresh cartilage tissue for joint repair and skin allografts to help heal severe burns, AlloSource delivers unparalleled expertise and service to its growing network of surgeons, partners, and the country's most reputable organ procurement organizations. (medindia.net)
  • Surgeons should look at these studies that show the same finding and choose structural allograft when performing ACDF," Dr. Than said. (spineuniverse.com)
  • Dan Leary , Vice President and General Manager of Parametrics Medical, said, "The release of our Coll-e-Strong line of allografts gives surgeons the opportunity to have the best of both worlds. (biospace.com)
  • For the first time, surgeons can have an allograft with strength qualities equivalent to an autograft that is also truly sterile. (biospace.com)
  • If surgeons at your facility use these allografts/supplies frequently, consider reviewing these cases and the charge structure to ensure that you capture and report their total cost. (hcpro.com)
  • These two new sizes are the largest allografts available, offering surgeons a human tissue form that reduces the need to suture smaller sheets together. (bio-medicine.org)
  • The limiting factors for utilizing HCV allografts include patient scepticism about receiving infected organs and physician concerns about post-transplant complications. (medscape.com)
  • The transplant is called an allograft, allogeneic transplant, or homograft. (wikipedia.org)
  • This study not only provides new insights into the nature of lung allografts as a primary site where T and B cell priming and immune regulation can occur, but also introduces the mouse orthotopic lung transplant as a model for studying the immunobiology of AMR. (jci.org)
  • The time is not far away when a combination of morphological changes on renal allograft biopsies with the molecular markers will be a feasible option to arrive at the most precise diagnosis of the transplant lesions. (omicsonline.org)
  • EDISON, N.J., Nov. 16, 2010 /PRNewswire/ -- The largest natural allograft available on the market today for hernia and abdominal wall repair has been announced by The Musculoskeletal Transplant Foundation (MTF), the nation's leading provider of allograft tissue. (bio-medicine.org)
  • Lee WP, Yaremchuk MJ, Pan YC et al (1991) Relative antigenicity of components of a vascularized limb allograft. (springer.com)
  • To determine whether there were any extra-lymphoid sites that might harbor regulatory T cells we sought their presence in tolerated skin allografts and in normal skin. (rupress.org)
  • Alachua, FL), a processor of precision-tooled orthopedic allografts , announced that it has signed an exclusive license and distribution services agreement with the Stryker Endoscopy division of Stryker Corporation (Kalamazoo, MI) to supply human allograft tissue for sports medicine surgeries. (thefreedictionary.com)
  • identifies a critical role of Foxp3+ T cells residing within lung allografts in the regulation of AMR. (jci.org)
  • However, formal oesophageal pH studies, when carried out, do indicate that GOR may be a significant problem in lung allografts and fundoplication surgery is associated with improved allograft function. (bmj.com)
  • The study was approved by the local research ethics committees for Newcastle and North Tyneside, with separate applications for prospective studies in lung allografts and normal volunteer controls. (bmj.com)
  • Tendon allograft sterilized by peracetic acid/ethanol combined with gamma irradiation. (sigmaaldrich.com)
  • Peracetic acid-ethanol in combination with low-dose gamma irradiation (PE-R) would inactivate potential deleterious microorganisms without affecting mechanical and biocompatible properties of tendon allograft. (sigmaaldrich.com)
  • Histological structure and ultrastructure were unchanged in the treated tendon allograft, which also exhibited comparable biomechanical properties and good biocompatibility. (sigmaaldrich.com)
  • However, most sterilisation methods cannot inactivate viruses and bacteria without impairing the mechanical properties of the tendon allograft. (sigmaaldrich.com)