Cross Reactions: Serological reactions in which an antiserum against one antigen reacts with a non-identical but closely related antigen.Immunoglobulin E: An immunoglobulin associated with MAST CELLS. Overexpression has been associated with allergic hypersensitivity (HYPERSENSITIVITY, IMMEDIATE).Drug Hypersensitivity: Immunologically mediated adverse reactions to medicinal substances used legally or illegally.Hypersensitivity, Delayed: An increased reactivity to specific antigens mediated not by antibodies but by cells.Immune Sera: Serum that contains antibodies. It is obtained from an animal that has been immunized either by ANTIGEN injection or infection with microorganisms containing the antigen.Enzyme-Linked Immunosorbent Assay: An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.Fluorescent Antibody Technique: Test for tissue antigen using either a direct method, by conjugation of antibody with fluorescent dye (FLUORESCENT ANTIBODY TECHNIQUE, DIRECT) or an indirect method, by formation of antigen-antibody complex which is then labeled with fluorescein-conjugated anti-immunoglobulin antibody (FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT). The tissue is then examined by fluorescence microscopy.Hypersensitivity, Immediate: Hypersensitivity reactions which occur within minutes of exposure to challenging antigen due to the release of histamine which follows the antigen-antibody reaction and causes smooth muscle contraction and increased vascular permeability.Skin Tests: Epicutaneous or intradermal application of a sensitizer for demonstration of either delayed or immediate hypersensitivity. Used in diagnosis of hypersensitivity or as a test for cellular immunity.Hypersensitivity: Altered reactivity to an antigen, which can result in pathologic reactions upon subsequent exposure to that particular antigen.Anaphylaxis: An acute hypersensitivity reaction due to exposure to a previously encountered ANTIGEN. The reaction may include rapidly progressing URTICARIA, respiratory distress, vascular collapse, systemic SHOCK, and death.Dermatitis, Contact: A type of acute or chronic skin reaction in which sensitivity is manifested by reactivity to materials or substances coming in contact with the skin. It may involve allergic or non-allergic mechanisms.Drug Eruptions: Adverse cutaneous reactions caused by ingestion, parenteral use, or local application of a drug. These may assume various morphologic patterns and produce various types of lesions.Diphenhydramine: A histamine H1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a hypnotic, an antiparkinson, and as an ingredient in common cold preparations. It has some undesired antimuscarinic and sedative effects.Passive Cutaneous Anaphylaxis: An evanescent cutaneous reaction occurring when antibody is injected into a local area on the skin and antigen is subsequently injected intravenously along with a dye. The dye makes the rapidly occurring capillary dilatation and increased vascular permeability readily visible by leakage into the reaction site. PCA is a sensitive reaction for detecting very small quantities of antibodies and is also a method for studying the mechanisms of immediate hypersensitivity.Dinitrofluorobenzene: Irritants and reagents for labeling terminal amino acid groups.Arthus Reaction: A dermal inflammatory reaction produced under conditions of antibody excess, when a second injection of antigen produces intravascular antigen-antibody complexes which bind complement, causing cell clumping, endothelial damage, and vascular necrosis.Picryl Chloride: A hapten that generates suppressor cells capable of down-regulating the efferent phase of trinitrophenol-specific contact hypersensitivity. (Arthritis Rheum 1991 Feb;34(2):180).Intradermal Tests: Skin tests in which the sensitizer is injected.Dermatitis, Allergic Contact: A contact dermatitis due to allergic sensitization to various substances. These substances subsequently produce inflammatory reactions in the skin of those who have acquired hypersensitivity to them as a result of prior exposure.Haptens: Small antigenic determinants capable of eliciting an immune response only when coupled to a carrier. Haptens bind to antibodies but by themselves cannot elicit an antibody response.Skin: The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.Oxazolone: Immunologic adjuvant and sensitizing agent.Dideoxynucleosides: Nucleosides that have two hydroxy groups removed from the sugar moiety. The majority of these compounds have broad-spectrum antiretroviral activity due to their action as antimetabolites. The nucleosides are phosphorylated intracellularly to their 5'-triphosphates and act as chain-terminating inhibitors of viral reverse transcription.Stevens-Johnson Syndrome: Rare cutaneous eruption characterized by extensive KERATINOCYTE apoptosis resulting in skin detachment with mucosal involvement. It is often provoked by the use of drugs (e.g., antibiotics and anticonvulsants) or associated with PNEUMONIA, MYCOPLASMA. It is considered a continuum of Toxic Epidermal Necrolysis.Immunity, Cellular: Manifestations of the immune response which are mediated by antigen-sensitized T-lymphocytes via lymphokines or direct cytotoxicity. This takes place in the absence of circulating antibody or where antibody plays a subordinate role.Alveolitis, Extrinsic Allergic: A common interstitial lung disease caused by hypersensitivity reactions of PULMONARY ALVEOLI after inhalation of and sensitization to environmental antigens of microbial, animal, or chemical sources. The disease is characterized by lymphocytic alveolitis and granulomatous pneumonitis.Food Hypersensitivity: Gastrointestinal disturbances, skin eruptions, or shock due to allergic reactions to allergens in food.Desensitization, Immunologic: Immunosuppression by the administration of increasing doses of antigen. Though the exact mechanism is not clear, the therapy results in an increase in serum levels of allergen-specific IMMUNOGLOBULIN G, suppression of specific IgE, and an increase in suppressor T-cell activity.Guinea Pigs: A common name used for the genus Cavia. The most common species is Cavia porcellus which is the domesticated guinea pig used for pets and biomedical research.Latex Hypersensitivity: Allergic reaction to products containing processed natural rubber latex such as rubber gloves, condoms, catheters, dental dams, balloons, and sporting equipment. Both T-cell mediated (HYPERSENSITIVITY, DELAYED) and IgE antibody-mediated (HYPERSENSITIVITY, IMMEDIATE) allergic responses are possible. Delayed hypersensitivity results from exposure to antioxidants present in the rubber; immediate hypersensitivity results from exposure to a latex protein.Tuberculin: A protein extracted from boiled culture of tubercle bacilli (MYCOBACTERIUM TUBERCULOSIS). It is used in the tuberculin skin test (TUBERCULIN TEST) for the diagnosis of tuberculosis infection in asymptomatic persons.Patch Tests: Skin tests in which the sensitizer is applied to a patch of cotton cloth or gauze held in place for approximately 48-72 hours. It is used for the elicitation of a contact hypersensitivity reaction.Antigens: Substances that are recognized by the immune system and induce an immune reaction.Dinitrochlorobenzene: A skin irritant that may cause dermatitis of both primary and allergic types. Contact sensitization with DNCB has been used as a measure of cellular immunity. DNCB is also used as a reagent for the detection and determination of pyridine compounds.Exanthema: Diseases in which skin eruptions or rashes are a prominent manifestation. Classically, six such diseases were described with similar rashes; they were numbered in the order in which they were reported. Only the fourth (Duke's disease), fifth (ERYTHEMA INFECTIOSUM), and sixth (EXANTHEMA SUBITUM) numeric designations survive as occasional synonyms in current terminology.Histamine H1 Antagonists: Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood.Urticaria: A vascular reaction of the skin characterized by erythema and wheal formation due to localized increase of vascular permeability. The causative mechanism may be allergy, infection, or stress.Erythema: Redness of the skin produced by congestion of the capillaries. This condition may result from a variety of causes.Basophils: Granular leukocytes characterized by a relatively pale-staining, lobate nucleus and cytoplasm containing coarse dark-staining granules of variable size and stainable by basic dyes.Dentin SensitivityAllergens: Antigen-type substances that produce immediate hypersensitivity (HYPERSENSITIVITY, IMMEDIATE).Mast Cells: Granulated cells that are found in almost all tissues, most abundantly in the skin and the gastrointestinal tract. Like the BASOPHILS, mast cells contain large amounts of HISTAMINE and HEPARIN. Unlike basophils, mast cells normally remain in the tissues and do not circulate in the blood. Mast cells, derived from the bone marrow stem cells, are regulated by the STEM CELL FACTOR.Paclitaxel: A cyclodecane isolated from the bark of the Pacific yew tree, TAXUS BREVIFOLIA. It stabilizes MICROTUBULES in their polymerized form leading to cell death.Carbamazepine: An anticonvulsant used to control grand mal and psychomotor or focal seizures. Its mode of action is not fully understood, but some of its actions resemble those of PHENYTOIN; although there is little chemical resemblance between the two compounds, their three-dimensional structure is similar.Sulfamethoxazole: A bacteriostatic antibacterial agent that interferes with folic acid synthesis in susceptible bacteria. Its broad spectrum of activity has been limited by the development of resistance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p208)Mice, Inbred BALB CImmunization: Deliberate stimulation of the host's immune response. ACTIVE IMMUNIZATION involves administration of ANTIGENS or IMMUNOLOGIC ADJUVANTS. PASSIVE IMMUNIZATION involves administration of IMMUNE SERA or LYMPHOCYTES or their extracts (e.g., transfer factor, immune RNA) or transplantation of immunocompetent cell producing tissue (thymus or bone marrow).T-Lymphocytes: Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.Ovalbumin: An albumin obtained from the white of eggs. It is a member of the serpin superfamily.Premedication: Preliminary administration of a drug preceding a diagnostic, therapeutic, or surgical procedure. The commonest types of premedication are antibiotics (ANTIBIOTIC PROPHYLAXIS) and anti-anxiety agents. It does not include PREANESTHETIC MEDICATION.Conjunctivitis, Allergic: Conjunctivitis due to hypersensitivity to various allergens.Antineoplastic Agents, Phytogenic: Agents obtained from higher plants that have demonstrable cytostatic or antineoplastic activity.Antibody Formation: The production of ANTIBODIES by proliferating and differentiated B-LYMPHOCYTES under stimulation by ANTIGENS.Dapsone: A sulfone active against a wide range of bacteria but mainly employed for its actions against MYCOBACTERIUM LEPRAE. Its mechanism of action is probably similar to that of the SULFONAMIDES which involves inhibition of folic acid synthesis in susceptible organisms. It is also used with PYRIMETHAMINE in the treatment of malaria. (From Martindale, The Extra Pharmacopoeia, 30th ed, p157-8)Carbazilquinone: An alkylating agent structurally similar to MITOMYCIN and found to be effective in the treatment of leukemia and various other neoplasms in mice. It causes leukemia and thrombocytopenia in almost all human patients.Castor Oil: Oil obtained from seeds of Ricinus communis that is used as a cathartic and as a plasticizer.Irritants: Drugs that act locally on cutaneous or mucosal surfaces to produce inflammation; those that cause redness due to hyperemia are rubefacients; those that raise blisters are vesicants and those that penetrate sebaceous glands and cause abscesses are pustulants; tear gases and mustard gases are also irritants.Cell Migration Inhibition: Phenomenon of cell-mediated immunity measured by in vitro inhibition of the migration or phagocytosis of antigen-stimulated LEUKOCYTES or MACROPHAGES. Specific CELL MIGRATION ASSAYS have been developed to estimate levels of migration inhibitory factors, immune reactivity against tumor-associated antigens, and immunosuppressive effects of infectious microorganisms.Immunization, Passive: Transfer of immunity from immunized to non-immune host by administration of serum antibodies, or transplantation of lymphocytes (ADOPTIVE TRANSFER).Histamine Release: The secretion of histamine from mast cell and basophil granules by exocytosis. This can be initiated by a number of factors, all of which involve binding of IgE, cross-linked by antigen, to the mast cell or basophil's Fc receptors. Once released, histamine binds to a number of different target cell receptors and exerts a wide variety of effects.Anti-Allergic Agents: Agents that are used to treat allergic reactions. Most of these drugs act by preventing the release of inflammatory mediators or inhibiting the actions of released mediators on their target cells. (From AMA Drug Evaluations Annual, 1994, p475)Mice, Inbred C57BLAntivenins: Antisera used to counteract poisoning by animal VENOMS, especially SNAKE VENOMS.Organoplatinum Compounds: Organic compounds which contain platinum as an integral part of the molecule.Genital Neoplasms, Female: Tumor or cancer of the female reproductive tract (GENITALIA, FEMALE).Spleen: An encapsulated lymphatic organ through which venous blood filters.Bronchial Spasm: Spasmodic contraction of the smooth muscle of the bronchi.Respiratory Hypersensitivity: A form of hypersensitivity affecting the respiratory tract. It includes ASTHMA and RHINITIS, ALLERGIC, SEASONAL.HLA-B Antigens: Class I human histocompatibility (HLA) surface antigens encoded by more than 30 detectable alleles on locus B of the HLA complex, the most polymorphic of all the HLA specificities. Several of these antigens (e.g., HLA-B27, -B7, -B8) are strongly associated with predisposition to rheumatoid and other autoimmune disorders. Like other class I HLA determinants, they are involved in the cellular immune reactivity of cytolytic T lymphocytes.Infusions, Intravenous: The long-term (minutes to hours) administration of a fluid into the vein through venipuncture, either by letting the fluid flow by gravity or by pumping it.BCG Vaccine: An active immunizing agent and a viable avirulent attenuated strain of Mycobacterium tuberculosis, var. bovis, which confers immunity to mycobacterial infections. It is used also in immunotherapy of neoplasms due to its stimulation of antibodies and non-specific immunity.Petrolatum: A colloidal system of semisolid hydrocarbons obtained from PETROLEUM. It is used as an ointment base, topical protectant, and lubricant.Lymph Nodes: They are oval or bean shaped bodies (1 - 30 mm in diameter) located along the lymphatic system.Lymphocyte Activation: Morphologic alteration of small B LYMPHOCYTES or T LYMPHOCYTES in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by INTERLEUKINS; MITOGENS such as PHYTOHEMAGGLUTININS, and by specific ANTIGENS. It may also occur in vivo as in GRAFT REJECTION.Hyperalgesia: An increased sensation of pain or discomfort produced by mimimally noxious stimuli due to damage to soft tissue containing NOCICEPTORS or injury to a peripheral nerve.
These hypersensitivity reactions to tetrazepam share no cross-reactivity with other benzodiazepines. Tetrazepam is used ... Allergic reactions to tetrazepam occasionally occur involving the skin. Allergic reactions can develop to tetrazepam and it is ... Delayed type 4 allergic hypersensitivity reactions including maculopapular exanthema, erythematous rash, urticarial eruption, ... Kämpgen, E; Bürger, T; Bröcker, EB; Klein, CE (November 1995). "Cross-reactive type IV hypersensitivity reactions to ...
The most common adverse reactions associated with benznidazole are allergic dermatitis and peripheral neuropathy. It is ... Studies in animals have shown that benznidazole can cross the placenta. Due to its potential for teratogenicity, use of ... In rare instances, skin hypersensitivity can result in exfoliative skin eruptions, edema, and fever. Peripheral neuropathy may ... Other adverse reactions include anorexia, weight loss, nausea, vomiting, insomnia, and dysguesia, and bone marrow suppression. ...
Side effects of penicillin
Many people have indicated that they have a side effect related to an allergic reaction to penicillin. It has been proposed ... Common adverse drug reactions (≥ 1% of people) associated with use of the penicillins include diarrhoea, hypersensitivity, ... Those medications that may cause a cross sensitivity reaction are: carbapenems, ampicillin, cefazolin, cephalosporins and ... Some of these reactions are visible and some occur in the body's organs or blood. Penicillins are a widely used group of ...
In type I hypersensitivity allergic reactions, an allergen (a type of antigen) interacts with and cross-links surface IgE ... These indications may include: Allergic rhinitis Allergic conjunctivitis Allergic dermatological conditions (contact dermatitis ... helping to relieve from allergic reactions. Agents where the main therapeutic effect is mediated by negative modulation of ... This is due to their relative lack of selectivity for the H1-receptor and their ability to cross the blood-brain barrier. The ...
If an allergic reaction to ceftaroline occurs, the drug should be discontinued. Serious acute hypersensitivity reactions ... If this product is to be given to penicillin- or other beta-lactam-allergic patients, caution should be exercised because cross ... Serious hypersensitivity (anaphylactic) reactions and serious skin reactions have been reported with beta-lactam antibiotics, ... Before therapy with ceftaroline is instituted, careful inquiry about previous hypersensitivity reactions to other ...
Some allergic reactions are not to the latex itself, but from residues of chemicals used to accelerate the cross-linking ... typically taking the form of Type IV hypersensitivity in the presence of traces of specific processing chemicals. ... Allergic reactions. Main article: Latex allergy. Some people have a serious latex allergy, and exposure to natural latex ... Latex from non-Hevea sources, such as Guayule, can be used without allergic reaction by persons with an allergy to Hevea latex. ...
Rare side effects (occurring in fewer than 1% of users) include allergic reactions, skin rash, fever, headaches, tremor, nausea ... Amikacin should be avoided in those who are sensitive to any aminoglycoside, as they are cross-allergenic (that is, an allergy ... to one aminoglycoside also confers hypersensitivity to other aminoglycosides). It should also be avoided in those sensitive to ... Side effects in animals include nephrotoxicity, ototoxicity, and allergic reactions at IM injection sites. Cats tend to be more ...
Some of these cross-react to allergens from house dust mites. Immediate antibody-mediated allergic reactions (wheals) have been ... immediate hypersensitivity of this type is thought to explain the observed far more rapid allergic skin response to reinfection ... The symptoms of scabies are due to an allergic reaction to the mites. Often, only between 10 and 15 mites are involved in an ... The allergic reaction is both of the delayed (cell-mediated) and immediate (antibody-mediated) type, and involves IgE ( ...
Cross-allergic reactions occur among the β-lactam antibiotics. To determine whether treatment with a β-lactam is safe when an ... The major antigenic determinant of penicillin hypersensitivity is its metabolite, penicilloic acid, which reacts with proteins ... Approximately five percent of patients have some kind of reaction, ranging from maculopapular rash (the most common rash seen ... Hypersensitivity is the most important adverse effect of the penicillins. ...
This is more likely if the patient is allergic to a certain cephalosporin known as ceftazidime. Azetreonam exhibits cross- ... However, like other beta lactams, there is a risk of very serious allergic reactions, including anaphylaxis. The aztreonam ... and it may be safe to administer aztreonam to many patients with hypersensitivity (allergies) to penicillins and nearly all ... Serious side effects include Clostridium difficile infection and allergic reactions including anaphylaxis. Those who are ...
... cytokines are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, ... The 2 types of cells also cross-regulate the functions of the other. T-cell exhaustion is mediated by several inhibitory ... whereas Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic ...
Allergic contact dermatitis
As it involves a cell-mediated allergic response, ACD is termed a Type IV delayed hypersensitivity reaction, making it an ... have the physico-chemical properties that allow them to cross the stratum corneum of the skin. They can only cause their ... By its allergic nature, this form of contact dermatitis is a hypersensitive reaction that is atypical within the population. ... exception in the usage of the designation "allergic," which otherwise usually refers to type I hypersensitivity reactions. ...
The previous percentage of 10% cross reactivity rates are often overestimated. Allergic reactions may present as, for example, ... Cefaclor should be avoided if there is a history of immediate hypersensitivity reaction); renal impairment (no dose adjustment ... The principal side effect of the cephalosporins is hypersensitivity. Penicillin-sensitive patients will also be allergic to the ... Cefaclor has also been reported to cause a serum sickness-like reaction in children. Cefaclor is contraindicated in case of ...
Hypoallergenic dog breed
Bathing a dog at least twice a week will minimize or even eliminate the reaction of an allergic person to a dog. Frequent ... Individuals with dog allergy may also be at increased risk for human protein hypersensitivity with cross-reactivity of dog ... While "allergy shots" can reduce many individuals' dog-allergic reactions, the most common approach remains avoidance.[citation ... Small hairless dogs may be less likely to cause allergic reactions "because it's so easy to bathe them and the dander falls off ...
... and hypersensitivity reactions. When used in large doses, they may cause a strong allergic reaction. Two of the most serious ... available evidence suggests that patients who are allergic to arylamine sulfonamides do not cross-react to sulfonamides that ... The first is the N1 heterocyclic ring, which causes a type I hypersensitivity reaction. The second is the N4 amino nitrogen ... Of note is the observation that patients with HIV have a much higher prevalence, at about 60%. Hypersensitivity reactions are ...
Lockey, SD (September-October 1959). "Allergic reactions due to F D and C Yellow No. 5, tartrazine, an aniline dye used as a ... Since the 1940s, researchers worldwide had discussed cross-reactions of aspirin (a common salicylate) and tartrazine (FD&C ... 1977). "Hypersensitivity to tartrazine (FD&C Yellow No. 5) and other dyes and additives present in foods and pharmaceutical ... diets not only eliminated allergic-type reactions such as asthma, eczema and hives, but also induced behavioral changes in some ...
Of these, histamine appears the most important in the initial phase of reaction. The allergic reaction develops at the site ... A hypersensitivity reaction to specific allergens (protein molecules causing an extreme immune response in sensitised ... These allergens appear to be cross-reactive across many species of Culicoides - i.e. many different varieties of midges produce ... Culicoides Hypersensitivity. Sweet Itch is a medical condition in equines caused by an allergic response to the bites of ...
One study has shown the allergic reaction rate to be about 3.0% over 359 courses of therapy. Of the allergic reactions, skin ... Therefore, the liver and kidney are the determining factors of these other hypersensitivity reactions; alterations in kidney or ... Wulf, Matuszewski (2013). "Sulfonamide cross-reactivity: Is there evidence to support broad cross-allergenicity?". Clinical ... Allergic reactions to Sulfonamides have been shown to include the entire Gel-Coombs spectrum of hyperactivity reactions. Type 1 ...
Rather, they are allergic hypersensitivity reactions caused by the non-toxic allergenic proteins contained in the mosquito's ... The top of the mouth, the labrum, has developed into a channeled blade the length of the proboscis, with a cross-section like ... There are both immediate hypersensitivity reactions (types I and III) and delayed hypersensitivity reactions (type IV) to ... life-threatening allergic reactions. These include ordinary wheal and flare reactions and mosquito bite allergies (MBA). The ...
Allergic reactions to anaesthesia
The incidence of life-threatening hypersensitivity reactions occurring during surgery and anaesthesia is around one in 10,000 ... Skin testing is often useful to identify potentially cross-reactive compounds and appropriate therapeutic alternatives. This is ... Serious allergic reactions to anesthetic medications are rare and a usually attributable to factors other than the anesthetic. ... Anaesthetists are trained to recognise if an allergic reaction is occurring. The identification of a complication is made by ...
... of patients with allergic hypersensitivity to penicillins and/or carbapenems also having cross-reactivity with cephalosporins ... Hence, it was commonly stated that they are contraindicated in patients with a history of severe, immediate allergic reactions ... Only the frequency of these reactions vary, based on the structure. Recent papers have shown that a major feature in ... Overall, the research shows that all beta lactams have the intrinsic hazard of very serious hazardous reactions in susceptible ...
... should not be confused with delayed hypersensitivity Type IV allergic reaction (which takes 48-72 hours to develop and is ... by mast cells following the cross-linking of allergen specific IgE molecules bound to mast cell FcεRI receptors. These ... Allergic reactions may generally be divided into two components; the early phase reaction, and the late phase reaction. While ... allergen exposure and is also commonly referred to as the immediate allergic reaction or as a Type I allergic reaction. The ...
Allergic reactions or infections with Clostridium difficile, a cause of diarrhea, are also possible. Use during pregnancy or ... Hypersensitivity reactions include skin rashes, urticaria, fever, and anaphylaxis. Pseudomembranous colitis and Clostridium ... Caution must be exercised when administering cephalosporin antibiotics to penicillin-sensitive patients, because cross ... Signs and symptoms of an allergic reaction include rash, itching, swelling, trouble breathing, or red, blistered, swollen, or ...
Bet v I allergen
Allergies are hypersensitivity reactions of the immune system to specific substances called allergens (such as pollen, stings, ... First contact with these allergens results in sensitisation; subsequent contact produces a cross-linking reaction of IgE on ... The inevitable symptoms of an allergic reaction ensue. A nomenclature system has been established for antigens (allergens) that ...
... reactions in this syndrome are hypersensitivity reactions to NSAIDs rather than the typically described true allergic reactions ... reported a multi-center prospective randomized cross-over trial with 30 patients following a low-salicylate diet for 6 weeks. ... The NSAID-induced reactions do not appear to involve the common mediators of true allergic reactions, immunoglobulin E or T ... EAACI/WHO classifies the syndrome as one of 5 types of NSAID hypersensitivity or NSAID hypersensitivity reactions. The various ...
However, allergic reactions can rarely occur. Clinically significant adverse events result from systemic absorption of ... Bupivacaine is contraindicated in patients with known hypersensitivity reactions to bupivacaine or amino-amide anesthetics. It ... Bupivacaine crosses the placenta and is a pregnancy category C drug. However, it is approved for use at term in obstetrical ... As a result, the amino-amide anesthetics are more stable and less likely to cause allergic reactions. Unlike lidocaine, the ...
... and/or allergic disorders have an increased risk of a hypersensitivity reaction to gadobutrol. Hypersensitivity reactions can ... However, other GBCAs have been shown to cross the placenta in humans and result in fetal exposure, but do not show adverse ... These reactions can include but are not limited to the following: Headache Nausea and/or vomiting Injection site reactions ( ... The most severe reaction to gadobutrol is nephrogenic system fibrosis (NSF) among patients with impaired elimination of the ...
IgG are also involved in the regulation of allergic reactions. According to Finkelman, there are two pathways of systemic ... IgG is also associated with type II and type III hypersensitivity reactions. IgG antibodies are generated following class ... which then cross-link macrophage receptor FcγRIII and stimulates only PAF release. IgG antibodies can prevent IgE mediated ... anaphylaxis: antigens can cause systemic anaphylaxis in mice through classic pathway by cross-linking IgE bound to the mast ...
It is relatively toxic to humans, and many people have allergic reactions to it. See: Hypersensitivity. Physicians sometimes ... "G418/neomycin-cross resistance?". Retrieved 2008-10-19. Mehta, Roopal; Champney, W. Scott (2003). "Neomycin and Paromomycin ... Heidary, Noushin; Cohen, David E. (2005). "Hypersensitivity reactions to vaccine components". Dermatitis. 16 (3): 115-20. doi: ... It is a basic compound that is most active with an alkaline reaction. It is also a thermostable compound that is soluble in ...
NIOSHTIC-2 Publications Search - 20037735 - Allergic contact dermatitis to synthetic rubber gloves: changing trends in patch...
Observations: We describe 23 patients with allergic contact dermatitis due to rubber accelerators in rubber gloves, some with ... Rubber gloves are one of the most frequent causes of occupational allergic contact dermatitis, especially in health care ... Chemical-hypersensitivity; Author Keywords: Health-Care Workers; Cross-Sectional Data; IV Allergy; Protective Gloves; Latex ... Dermatitis; Allergic-dermatitis; Allergic-reactions; Allergies; Skin-exposure; Skin-sensitivity; Health-care-personnel; Gloves ...
Antibody-mediated hypersensitivity reaction - definition of antibody-mediated hypersensitivity reaction by The Free Dictionary
antibody-mediated hypersensitivity reaction synonyms, antibody-mediated hypersensitivity reaction pronunciation, antibody- ... mediated hypersensitivity reaction translation, English dictionary definition of antibody-mediated hypersensitivity reaction. n ... reaction. n reacción f; adverse - reacción adversa; allergic - reacción alérgica; conversion - trastorno de conversión; cross - ... Antibody-mediated hypersensitivity reaction - definition of antibody-mediated hypersensitivity reaction by The Free Dictionary ...
Scilex Announces New Medicaid Agreements with CA & FL
Hypersensitivity cross-reactions may be possible for patients allergic to PABA derivatives. Manage hypersensitivity reactions ... Adverse Reactions. Side effects of ZTlido include application site reactions such as, irritation, erythema, and pruritus. These ... These reactions are generally mild and transient, resolving spontaneously within a few minutes to hours. Inform patients of ... Application site reactions can occur during or immediately after treatment with ZTlido. This may include development of ...
Compositions containing both sedative and non-sedative antihistamines and sleep aids - Collegium Pharmaceutical, Inc.
Hypersensitivity usually causes tissue damage. Typical hypersensitivity reactions are allergic rhinitis, allergic ... CROSS-REFERENCE TO RELATED APPLICATIONS This application is a continuation-in-part of U.S. Ser. No. 10/012,202, filed Dec. 5, ... The method of inhibiting the release of histamine defined in claim 19 wherein the patient suffers from allergic reaction, ... and various other allergic or rhinitis-stimulating reactions. Examples of the antitussives that may be employed include ...
Tazicef Side Effects in Detail - Drugs.com
Cross reactions may occur in penicillin-allergic or aztreonam-allergic patients. Rarely, angioedema and anaphylactic reactions ... Hypersensitivity. Mild hypersensitivity reactions, such as rash, pruritus, and fever, have been reported and may necessitate ... Allergic reactions including cardiopulmonary arrest have been reported during postmarketing experience. Cephalosporin class ... Hypersensitivity reactions including rash, pruritus, and fever have been reported (2%). ...
Ceftaroline Fosamil (Professional Patient Advice) - Drugs.com
Includes: pharmacology, pharmacokinetics, contraindications, interactions, adverse reactions and more. ... Hypersensitivity: Serious hypersensitivity (anaphylactic) and skin reactions have occurred with ceftaroline. Use with caution ... Maintain clinical supervision if given to penicillin or beta-lactam allergic patients; cross sensitivity among beta-lactam ... Adverse Reactions. The following reactions occurred in all indicated populations unless otherwise specified. ...
DailyMed - CEFTRIAXONE AND DEXTROSE- ceftriaxone injection, solution
Cross-hypersensitivity may occur in up to 10% of patients with a history of penicillin allergy. If an allergic reaction occurs ... Patients should be advised that allergic reactions, including serious allergic reactions could occur and that serious reactions ... Adverse Reactions: Allergic reactions, drug fever, serum sickness-like reaction, renal dysfunction, toxic nephropathy, ... 5.5 Hypersensitivity to Dextrose Products. Hypersensitivity reactions, including anaphylaxis, have been reported with ...
Allergic, Autoimmune, and Other Hypersensitivity Disorders - Merck Manuals Professional Edition
... and other hypersensitivity disorders are inappropriate or exaggerated immune reactions to foreign antigens. Inappropriate ... immune reactions include those that are misdirected against intrinsic body components, leading to . ... Cross-reaction with antibodies to a foreign antigen Am I Correct?. Latest News. ... Overview of Allergic and Atopic Disorders. *Classification of Hypersensitivity Reactions *Type I ...
Use of cephalosporins in patients with immediate penicillin hypersensitivity: cross-reactivity revisited | HKMJ
Allergic reactions to betalactams: studies in a group of patients allergic to penicillin and evaluation of cross-reactivity ... Allergic reactions are common side-effects of BL antibiotics. Studies in the 1960s and 1970s frequently estimated 10% cross- ... Lack of allergic cross-reactivity to cephalosporins among patients allergic to penicillins. Clin Exp Allergy 2001;31:438-43. ... Eleven (13.3%) patients with penicillin hypersensitivity also reported hypersensitivity reaction to other drugs such as non-BL ...
Clopidogrel (Plavix): Side Effects, Dosages, Treatment, Interactions, Warnings
Allergic cross-reactivity including rash, angioedema, or hematologic reaction among thienopyridines (e.g., ticlopidine, ... Immune system disorders: Hypersensitivity reactions, anaphylactoid reactions, serum sickness. *Musculoskeletal, connective ... Use caution or avoid in patients with hypersensitivity or hematologic reactions to previous thienopyridine use, including ... Patients allergic to aspirin who are undergoing percutaneous coronary intervention (PCI); see American Heart Association (AHA)/ ...
Tetrazepam - Wikipedia
These hypersensitivity reactions to tetrazepam share no cross-reactivity with other benzodiazepines. Tetrazepam is used ... Allergic reactions to tetrazepam occasionally occur involving the skin. Allergic reactions can develop to tetrazepam and it is ... Delayed type 4 allergic hypersensitivity reactions including maculopapular exanthema, erythematous rash, urticarial eruption, ... Kämpgen, E; Bürger, T; Bröcker, EB; Klein, CE (November 1995). "Cross-reactive type IV hypersensitivity reactions to ...
Search of: Recruiting, Not yet recruiting, Available Studies | 'Drug Hypersensitivity' - List Results - ClinicalTrials.gov
Allergic Hypersensitivity Drug Reaction Versus Non-allergic Hypersensitivity Drug Reaction Cross Reaction ... Allergic Versus Non Allergic Hypersensitivity Drug Reaction. *- To determine the proportion of drugs involved in in allergic ... Allergic Versus Non Allergic Hypersensitivity Drug Reaction (BdDAllergo). * ... hypersensitivity drug reaction for each pharmacotherapeutic class. *immediate allergic hypersensitivity and delayed allergic ...
Hematology/Oncology Flashcards by Andrew Rivera | Brainscape
Mediates allergic reaction in local tissues. Mast cells contain basophilic granules and originate from the same precursor as ... Involved in type 1 hypersensitivity reactions.. Cromolyn sodium prevents mast cell degranulation (used for asthma prophylaxis) ... Cross BBB into CNS. Cross link DNA. Use: Brain tumors (including glioblastoma multiforme). Toxicity:. CNS toxicity (convulsions ... Mediates allergic reaction. Densely basophilic granules contain heparin (anticoagulant) and histamine (vasodilator). ...
ASCIA Clinical Update Antibiotic Allergy - Australasian Society of Clinical Immunology and Allergy (ASCIA)
... of all adverse drug reactions are immune mediated, it is common for a patient to give a history of being allergic to an ... If penicillin is administered to a highly allergic patient, fatal anaphylaxis can occur. ... Delayed reactions. 3. Diagnosis of antibiotic hypersensitivity. 3.1. Clinical History. 3.2. Skin and blood testing. 3.3. Cross ... 2. Types of antibiotic hypersensitivity. 2.1. IgE-mediated immediate hypersensitivity. 2.2. IgE-independent reactions. 2.3. ...
Drug Hypersensitivity syndrome - ONA
Avoidance of drug exposure in known allergic patients is key.. Medication cross-reaction is very important as well. For ... anticonvulsant hypersensitivity syndrome, dilantin hypersensitivity syndrome, and dapsone hypersensitivity syndrome. ... The more severe form of medication reaction is termed drug hypersensitivity syndrome (DHS) and is associated with systemic ... IVIG can be associated with severe allergic reaction, headache, volume overload, stroke, and other conditions. ...
Pfizer-BioNTech COVID-19 Vaccine Information | CDC
Immediate allergic reaction of any severity to polysorbate (due to potential cross-reactive hypersensitivity with the vaccine ... For the purpose of this guidance, an immediate allergic reaction is defined as any hypersensitivity-related signs or symptoms, ... Severe allergic reaction (e.g., anaphylaxis) to a previous dose or component of either mRNA COVID-19 vaccine. See Appendix B: ... Immediate allergic reaction* of any severity to a previous dose or component of an mRNA COVID-19 vaccine (including ...
Beechams Max Strength All in One Capsules, hard - Summary of Product Characteristics (SmPC) - (emc)
Allergic reactions (e.g. rash, urticaria, allergic dermatitis).. Hypersensitivity reactions - including that cross-sensitivity ... Adverse reactions identified during post-marketing use are listed below. The frequency of these reactions is unknown but likely ... but post-marketing experience indicates that adverse reactions to paracetamol are rare and serious reactions are very rare. ... Phenylephrine overdosage is likely to result in effects similar to those listed under adverse reactions. Additional symptoms ...
NIOSHTIC-2 Search Results - Full View
Dermatitis; Allergic-dermatitis; Allergic-reactions; Allergies; Skin-exposure; Skin-sensitivity; Health-care-personnel; Gloves ... Chemical-hypersensitivity; Author Keywords: Health-Care Workers; Cross-Sectional Data; IV Allergy; Protective Gloves; Latex ... Allergic contact dermatitis to synthetic rubber gloves: changing trends in patch test reactions to accelerators. ... Conclusions: Allergic contact dermatitis due to synthetic rubber gloves occurs even with the use of latex-safe products. More ...
Management of Nonsteroidal Anti-inflammatory Drug-Induced Hypersensitivity Reactions
Allergic NSAID-Induced. Hypersensitivity Reactions. Allergic NHRs are non-cross-reactive reactions, immunologically mediated ... Nonallergic NSAID-Induced Hypersensitivity Reactions. Nonallergic NSAID reactions are allergy-like reactions that are not ... nonallergic or cross-reactive reactions) versus those that are immunologically mediated (allergic or selective reactions). They ... Nonallergic NSAID reactions are known to be cross-reactive, and therefore, patients who experience them can have a reaction to ...
Analysis of Immunological Reactions to Foods in Birch Pollen-Allergic Patients - Full Text View - ClinicalTrials.gov
A high number of birch pollen-allergic individuals develop hypersensitivity reactions to certain foods, e.g. apples. This food ... Data obtained in this study will help to clarify the immunological and clinical role of cross-reactivity between pollen and ... Hypersensitivity. Rhinitis, Allergic. Food Hypersensitivity. Nose Diseases. Respiratory Tract Diseases. Respiratory Tract ... Analysis of Immunological Reactions to Foods in Birch Pollen-Allergic Patients. The safety and scientific validity of this ...
Microbiology Flashcards by Sukhpreet Dubb | Brainscape
Hypersensitivity reactions are usually manifested by an urticarial rash, although anaphylaxis may occur. Cross-sensitivity ... About 10% of patients who are allergic to penicillin are also allergic to cephalosporins. Rashes and fever may occur. In ... In patients allergic to peni- cillin, erythromycin is the drug of choice, but some strains are resistant. ... It is usually used as a second-line drug in patients allergic to penicillin. It is active against streptococci, staphylo- cocci ...
Excenel | Excenel RTU | Excenel Injection | Excenel Antibiotic
Amoxinsol | Amoxinsol Sachet | Amoxinsol 50 | Amoxinsol 100 | Amoxinsol | Amoxin
Hypersensitivity to penicillins may lead to cross reactions to cephalosporins and vice versa. Allergic reactions to these ... Hypersensitivity to penicillins may lead to cross reactions to cephalosporins and vice versa. Allergic reactions to these ... Penicillins and cephalosporins may cause hypersensitivity (allergy) following injection, inhalation, ingestion or skin contact ... Penicillins and cephalosporins may cause hypersensitivity (allergy) following injection, inhalation, ingestion and skin contact ...
DailyMed - VICOPROFEN- hydrocodone bitartrate and ibuprofen tablet, coated
... or allergic-type reactions after taking aspirin or other NSAIDs. Severe, rarely fatal, anaphylactic-like reactions to NSAIDs ... Since cross-reactivity between aspirin and other NSAIDs has been reported in such aspirin-sensitive patients, VICOPROFEN should ... VICOPROFEN is contraindicated in patients with known hypersensitivity to hydrocodone or ibuprofen. Patients known to be ... if you had an asthma attack, hives, or other allergic reaction with aspirin or any other NSAID medicine ...
Types of Hypersensitivity Reactions | Immunological and Inflammatory Aspects of Periodontal Disease | Continuing Education...
Types of Hypersensitivity Reactions Immunological and Inflammatory Aspects of Periodontal Disease Continuing Education Course ... as in allergic dermatitis (e.g., hives, wheal and erythema reactions). The reaction is the result of an antigen cross-linking ... Types of Hypersensitivity Reactions The response of the host to the presence of foreign substances can trigger four types of ... Evidence suggests that hypersensitivity reactions, particularly Type III and IV, may be involved in the pathogenesis of ...
FDA Approves Updated Label for Avycaz
Caution should be exercised if using this drug in patients allergic to penicillin or other β-lactams because cross-sensitivity ... Ceftazidime-avibactam should be discontinued if the patient develops an allergic reaction. ... It should not be used in patients who have a known serious hypersensitivity to either component, avibactam-containing products ... The most commonly reported adverse reactions in patients with cIAI (incidence of ≥ 5% when used with metronidazole) were ...
Anisakiasis and Gastroallergic Reactions Associated with Anisakis pegreffii Infection, Italy - Volume 19, Number 3-March 2013 -...
... especially in some European countries where allergic symptoms and hypersensitivity associated with the parasite have been ... The high level of IgE-As observed in the remaining serum specimens was likely related to cross-reactive antibodies against ... Western blot reaction of serum samples from patients HuC1 and HuC2 from Italy showing allergic reaction against Anisakis ... Western blot reaction of serum samples from patients HuC1 and HuC2 from Italy showing allergic reaction against Anisakis ...
Health Guide: Food Allergies
Most food allergies in rats are often of a delayed hypersensitivity response. In delayed hypersensitivity the allergic response ... Reactions takes place after the food is digested, and the allergens cross the gastrointestinal lining to enter the bloodstream ... A hypersensitivity or adverse reaction of body tissue to a food substance. Clinical Signs. Signs same as for dermatitis: * ... In general, IgE mediated reactions typically show with rapid development of symptoms, where as, in food hypersensitivity non- ...
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Hypersensitivity usually causes tissue damage. Typical hypersensitivity reactions are allergic rhinitis, allergic ... CROSS-REFERENCE TO RELATED APPLICATIONS. This application is a continuation-in-part of U.S. Ser. No. 10/012,202, filed Dec. 5, ... wherein the patient suffers from allergic reaction, allergic rhinitis, cold or flu. ... and various other allergic or rhinitis-stimulating reactions.. Examples of the antitussives that may be employed include ...
CephalosporinsDrug hypersensitivityAllergyAdverse reactionsContraindicationsDiagnosisAllergenAngioedemaNonsteroidal anti-CephalosporinAnaphylactoid reactionsContact dermatitisImmunologicalDisordersTypes of hypersensitivityReactivitySystemic reactionsAnticonvulsant hypersensitivity syndromeAntibodiesAllergiesSyndromeExposureCell-MediatedOccursMediatorsClinicallyImmune mediatedAcuteAntibodySerumAntibioticCutaneousProteinsSeverityResponsible for allergic reactionsClinicalSkin reactionsCause allergic reactionsDiseasesMast cells and basophilsInfectionsImmunologyAtopyMechanismAnaphylactic reactionsPatients who are allergicSensitizationDermatitisFatal
- A 10% cross-reactivity rate is commonly cited between penicillins and cephalosporins. (hkmj.org)
- Newer generations of cephalosporins possess side-chains that are dissimilar to those of penicillins, leading to low cross-reactivity. (hkmj.org)
- In the assessment of cross-reactivity between penicillins and cephalosporins, one has to take into account the background beta-lactam hypersensitivity, which occurs in up to 10% of patients. (hkmj.org)
- Use of cephalosporins in patients with penicillin hypersensitivity begins with detailed history and physical examination. (hkmj.org)
- Studies in the 1960s and 1970s frequently estimated 10% cross-reactivity between penicillins and cephalosporins. (hkmj.org)
- 3 4 Notably, cross-reactivity is higher between penicillins and first- and second-generation cephalosporins compared with third- and fourth-generation cephalosporins. (hkmj.org)
- In the following discussion, the author will review the use of cephalosporins in patients with immediate hypersensitivity to penicillins. (hkmj.org)
- Public hospitals often suggest avoiding all cephalosporins indiscriminately for patients with penicillin hypersensitivity, as exemplified by a recent antibiotic guideline. (hkmj.org)
- It should not be used in patients who have a known serious hypersensitivity to either component, avibactam-containing products, or other cephalosporins. (medscape.com)
- The immunological cross-reaction between penicillins and cephalosporins. (springer.com)
- Cross-reactivity between penicillins and cephalosporins: clinical and immunologic studies. (springer.com)
- Diagnosis and management of immediate hypersensitivity reactions to cephalosporins. (springer.com)
- Use of the product deviating from the instructions given in the S.P.C. may increase the prevalence of bacteria resistant to Cefalexin and may decrease the effectiveness of treatment with other cephalosporins and penicillins, due to the potential for cross-resistance. (vetuk.co.uk)
- Penicillins and cephalosporins may cause hypersensitivity (allergy) following injection, inhalation, ingestion or skin contact. (vetuk.co.uk)
- Those medications that may cause a cross sensitivity reaction are: carbapenems, ampicillin, cefazolin, cephalosporins and cloxacillin. (wikipedia.org)
- Do not use in animals with a known hypersensitivity to cephalosporins, other other ß-lactam antibiotics or to any of the excipients. (hyperdrug.co.uk)
- Hypersensitivity to penicillins may lead to cross reactions to cephalosporins and vice versa. (hyperdrug.co.uk)
- 3 If a patient's penicillin allergy is determined by reaction severity or allergy testing to represent a true allergy, then the clinician is faced with the challenge of determining and interpreting the rate of allergic cross-reactivity from the penicillin class to the other beta-lactam classes (ie, cephalosporins, carbapenems, and mono-bactams). (pharmacytimes.com)
- For cephalosporins, the rate of cross-reactivity with penicillins is lower than previously believed. (pharmacytimes.com)
- It appears that cross-reactivity between penicillins and cephalosporins is more likely associated with structurally similar side chains rather than the beta-lactam ring itself. (pharmacytimes.com)
- Cephalosporins mimic the structure of the D-Ala-D-Ala link and bind to the active site of PBPs, disrupting the cross-linking process. (emedexpert.com)
- Because the cephalosporins are structurally similar to the penicillins, some patients allergic to penicillins may be allergic to a cephalosporin antibiotic. (emedexpert.com)
- The overall cross-reactivity rate is about 1% when using first-generation cephalosporins or cephalosporins with similar R1 side chains. (emedexpert.com)
- Penicillins and cephalosporins cross-react to some extent, especially when the side-chains are identical (4). (phadia.com)
- Immediate allergic reactions to cephalosporins: Evaluation of cross-reactivity with a panel of penicillins and cephalosporins. (phadia.com)
- In addition, it is used to treat serious Gram-positive infections among patients who are allergic to semi-synthetic penicillins or cephalosporins ( 3 ). (frontiersin.org)
- Hypersensitivity to penicillins or to cephalosporins. (intekom.com)
- Cross-sensitivity between penicillins and cephalosporins is well documented. (intekom.com)
- Before initiating therapy with Amoxicap 250, careful enquiry should be made concerning previous hypersensitivity reactions to penicillins, cephalosporins or other allergens. (intekom.com)
- There have been reports of individuals with a history of penicillin hypersensitivity, who have experienced severe reactions when treated with cephalosporins. (intekom.com)
- Drug provocation test by experienced personnel remains the best way to exclude or confirm the diagnosis of drug hypersensitivity and to find a safe alternative for future use. (hkmj.org)
- Are you sure your patient has drug hypersensitivity syndrome? (oncologynurseadvisor.com)
- The more severe form of medication reaction is termed drug hypersensitivity syndrome (DHS) and is associated with systemic symptoms of fever, fatigue, and feeling ill and can involve multiple organs, especially the liver. (oncologynurseadvisor.com)
- General considerations on rapid desensitization for drug hypersensitivity - a consensus statement. (springer.com)
- This group of drug reactions includes drug hypersensitivity syndrome (DHS), acute generalized exanthematous pustulosis (AGEP), anticoagulant-induced skin necrosis, small-vessel vasculitis (SVV), propylthiouracil hypersensitivity vasculitis and serum sickness disease. (scielo.br)
- This article considers the following reactions: drug hypersensitivity syndrome (DHS), acute generalized exanthematous pustulosis (AGEP), anticoagulant-induced skin necrosis, small-vessel vasculitis, propylthiouracil hypersensitivity vasculitis and serum sickness disease type reactions. (scielo.br)
- all other reactions should be referred to as nonallergic drug hypersensitivity. (ingentaconnect.com)
- This volume contains articles by researchers and clinicians belonging to the European Network for Drug Allergy (the European Academy of Allergology and Clinical Immunology's interest group on drug hypersensitivity). (ingentaconnect.com)
- Cross-hypersensitivity may occur in up to 10% of patients with a history of penicillin allergy. (nih.gov)
- Most patients who report a penicillin allergy have a vague history and are not allergic at all. (allergy.org.au)
- This food allergy is due to immunological cross-reactivity. (clinicaltrials.gov)
- Nonallergic NSAID reactions are allergy-like reactions that are not immunologically mediated. (uspharmacist.com)
- 1. A Food Allergy or Hypersensitivity where the reaction may be immediate or delayed. (ratguide.com)
- and (5) penicillin allergy cross-reactivity with other beta-lactam antibiotics. (springer.com)
- In addition, a "latex fruit syndrome" has been described implying that, because of alleged allergen cross reactions, NRL allergic patients frequently show allergy to various fruits, such as banana, avocado, chestnut, and kiwi. (bmj.com)
- In addition to immediate type I allergy symptoms, NRL allergy can manifest on the hands of glove users as protein contact dermatitis or allergic contact dermatitis. (bmj.com)
- Local hypersensitivity reactions at mucosal surfaces play an important role in the pathophysiology of allergic diseases, including food allergy, atopic asthma, and rhinitis. (jimmunol.org)
- Sulfa allergy strictly refers to those patients who have a history of hypersensitivity to sulfonamide antibiotics. (scielo.org.za)
- Here, we aim to deliver an overview of the current state of specific inhibitors used in the treatment of allergy, with a particular focus on asthma and atopic dermatitis, and provide insights into the roles of these molecules in immunological mechanisms of allergic disease. (jci.org)
- Identifying an allergy to penicillin requires a hypersensitivity skin test which diagnoses IgE-mediated immune responses caused by penicillin. (wikipedia.org)
- With increasing need to prevent serious food allergy reactions, Korean food allergen labeling regulation has been revised repeat edly. (kstudy.com)
- The initial working differential diagnoses were septicaemia, a drug reaction, or possible food allergy (the patient was allergic to salmon and she had consumed some one day prior to admission). (bmj.com)
- bacterial allergy specific hypersensitivity to a particular bacterial antigen. (thefreedictionary.com)
- cold allergy a condition manifested by local and systemic reactions, mediated by histamine, which is released from mast cells and basophils as a result of exposure to cold. (thefreedictionary.com)
- drug allergy an allergic reaction occurring as the result of unusual sensitivity to a drug. (thefreedictionary.com)
- food allergy , gastrointestinal allergy allergy produced by ingested antigens in food, usually manifested by a skin reaction. (thefreedictionary.com)
- See also allergic reaction , allergy testing . (thefreedictionary.com)
- Additional factors which make mustard allergy relevant to the Canadian scenario include the potential cross reactivity between mustard and rape seed and the facts that, Canada is a major producer of both of these crops and sensitization to mustard can be acquired through dermal and respiratory exposure. (canada.ca)
- It is important to ascertain a patient's reported reaction and reaction timing with regard to administration to help indicate whether the allergy represents an immunoglobin (IgE)-mediated reaction, a delayed-onset reaction, an adverse effect, or simply an intolerance. (pharmacytimes.com)
- A common myth is that about 10% of patients with a penicillin allergy history will experience an allergic reaction if administered a cephalosporin. (pharmacytimes.com)
- therefore, the primary structural similarity that may confer allergic cross-sensitivity to those with a true penicillin allergy is the molecule's bicyclic core. (pharmacytimes.com)
- 2 The first study that attempted to evaluate the possible cross-reactivity rate from penicillin allergy to carbapenems evaluated the possible cross-reactivity to imipenem. (pharmacytimes.com)
- Antigenic specificities of allergic wheal-and-flare skin responses in patients with histories of penicillin allergy. (phadia.com)
- Although the exact mechanism isn't yet understood, allergy sufferers sometimes find that once they have become sensitized to certain allergens, they also exhibit allergic symptoms when exposed to related substances. (howstuffworks.com)
- In a systemic reaction, the release of allergy mediators (chief among them being histamine) causes capillaries all over the body to dilate. (howstuffworks.com)
- as demonstrated by a Spanish study, where fish allergy occurred in 22% of all patients with a diagnosis of food hypersensitivity. (phadia.com)
- Foods most frequently associated with food hypersensitivity and probable food allergy amongst 1992 late adolescents. (elsevier.es)
- Peanut allergy is an IgE-mediated hypersensitivity. (phys.org)
- Many foods can lead to allergic reactions and this situation is further complicated by so-called cross-reactions, whereby an allergy to one particular food can trigger allergic reactions to another food. (phys.org)
- Allergy is an immunological reaction (IgE-mediated hypersensitivity) to a medicine. (bpac.org.nz)
- A specific consideration with regard to the management of TN allergy is the decision to avoid all TNs or only the TNs to which a patient is clinically allergic. (dovepress.com)
- 8 For the purpose of this review, we will focus on the nine most common TNs that cause allergic reactions, and we do not extensively discuss peanut allergy (a legume). (dovepress.com)
- Initial and accidental reactions are managed inadequately in children with sesame allergy. (allallergy.net)
- IgE cross-reactivity of peanut with walnut and soybean in children with food allergy. (allallergy.net)
- These are not all of the adverse reactions that may occur. (globenewswire.com)
- The most common adverse reactions occurring in greater than 2% of patients receiving ceftriaxone include diarrhea, eosinophilia, thrombocytosis, leukopenia, and elevations of SGOT and SGPT. (nih.gov)
- Common adverse reactions include arthralgia and nausea . (wikidoc.org)
- Of the responses, 22% requested that mustard and/or mustard seeds be added to the list of priority allergens in the regulatory amendments based on observations or personal experiences of adverse reactions associated with the consumption of mustard and/or food products containing mustard and/or mustard seeds. (canada.ca)
- The most common adverse reactions associated with benznidazole are allergic dermatitis and peripheral neuropathy. (wikipedia.org)
- Adverse reactions: Hypersensitivity reaction may precipitate allergic reactions. (yogachicago.com)
- No adverse reactions known. (tabers.com)
- Common adverse reactions include bone pain . (wikidoc.org)
- Salsalate, like all nonsteroidal anti-inflammatory drugs (NSAIDs), may exacerbate hypertension and congestive heart failure (see Adverse Reactions) and may cause an increased risk of serious cardiovascular thrombotic events, myocardial infarction, and stroke, which can be fatal. (pdr.net)
- Closely monitor all patients for potential GI ulceration and bleeding (see Adverse Reactions). (pdr.net)
- Complete blood count with differential, liver function tests, coagulation studies, erythrocyte sedimentation rate, kidney function tests, urinalysis with microscopy, human herpesvirus-6 serologic assay or polymerase chain reaction are important to help in the diagnosis. (oncologynurseadvisor.com)
- Progesterone hypersensitivity is a clinical diagnosis. (verywellhealth.com)
- 2. That branch of medicine concerned with the study, diagnosis, and treatment of allergic manifestations. (thefreedictionary.com)
- The authors also provide data on IgE-mediated reactions, such as anaphylactic shock, urticaria and angioedema, and highlight the usefulness of the sepharose radioimmunoassay of serum-specific IgE against quinolones in the diagnosis of such reactions. (ingentaconnect.com)
- IgE-associated allergic disorders: Recent advances in etiology, diagnosis and treatment. (allallergy.net)
- Allergic reactions can develop to tetrazepam and it is considered to be a potential allergen. (wikipedia.org)
- Subsequent exposure to the culprit allergen can trigger IgE-mediated FcεRI cross-linking on mast cells and basophils, leading to a type I hypersensitivity reaction. (jci.org)
- Hypersensitivity caused by exposure to a particular antigen (allergen) resulting in a marked increase in reactivity to that antigen on subsequent exposure, sometimes resulting in harmful immunologic consequences. (thefreedictionary.com)
- 1. A state of hypersensitivity induced by exposure to a particular antigen/allergen, resulting in adverse immune reactions on subsequent re-exposure to the allergen. (thefreedictionary.com)
- Hypersensitivity to body contact with a foreign substance (an ALLERGEN ), especially grass or tree pollens, foods, dust, mites or certain metals such as nickel. (thefreedictionary.com)
- In satisfying all of the criteria, it has been recommended that mustard be added to the Canadian list of food allergens and that the Food Allergen Labelling Regulations, which require enhanced labelling for priority allergens in pre-packaged foods be updated accordingly in order to ensure that mustard allergic consumers in Canada are duly protected. (canada.ca)
- ImmunoCAP Allergen c6, Amoxicilloyl, is used for detection of IgE sensitization to the major allergenic determinant of amoxicillin, with potential cross-reactivity to other penicillins. (phadia.com)
- Then, if the allergen comes along again, it triggers a destructive domino effect within the system called the allergic cascade . (howstuffworks.com)
- In allergic reactions an allergen interacts with and cross-links surface IgE antibodies on mast cells and basophils. (drugbank.ca)
- In mast cells, cross-linking of FcεRI with allergen-specific IgE leads to release of inflammatory mediators such as histamine and serotonin, which are responsible for various allergic conditions including contact dermatitis and hypersensitivity ( 1 ). (jimmunol.org)
- Allergen cross-linking with specific immunoglobulin E (IgE) bound to FcεRI triggers mast cell activation, inducing the rapid secretion of preformed allergic mediators and de novo synthesized mediators, such as histamine, cytokines, proteases and derivatives of arachidonic acid ( 3 ). (spandidos-publications.com)
- The aim of this study was to generate antibody probes specific for important Alternaria allergens and to use them to study allergen expression, depending on different culture conditions, as well as to search for cross-reactive allergens in other mould species. (allallergy.net)
- ABSTRACT: Although nonsteroidal anti-inflammatory drugs (NSAIDs) are one of the most commonly prescribed and consumed drug classes, they are associated with a wide range of adverse effects, including NSAID-induced hypersensitivity reactions (NHRs). (uspharmacist.com)
- Non-allergic reactions may involve different pathogenic mechanisms, such as the capability of iodinated contrast media (ICM) of releasing mediators through a non-immunologic mechanism and the inhibitory effect on cyclooxygenase-1 of nonsteroidal anti-inflammatory drugs (NSAIDs). (ingentaconnect.com)
- Skin test for penicillin is not predictive of cephalosporin hypersensitivity, while cephalosporin skin test is not sensitive. (hkmj.org)
- Allergic reactions to betalactams: studies in a group of patients allergic to penicillin and evaluation of cross-reactivity with cephalosporin. (springer.com)
- Hypersensitivity to penicillin may lead to cross sensitivity to cephalosporin and vice versa. (vetuk.co.uk)
- Allergic contact dermatitis to synthetic rubber gloves: changing trends in patch test reactions to accelerators. (cdc.gov)
- Background: Rubber gloves are one of the most frequent causes of occupational allergic contact dermatitis, especially in health care workers. (cdc.gov)
- Observations: We describe 23 patients with allergic contact dermatitis due to rubber accelerators in rubber gloves, some with disseminated dermatitis, treated during a 2-year period. (cdc.gov)
- Conclusions: Allergic contact dermatitis due to synthetic rubber gloves occurs even with the use of latex-safe products. (cdc.gov)
- More knowledge about chemicals present in these gloves, to which the skin is exposed during use, is necessary to prevent and treat allergic contact dermatitis. (cdc.gov)
- Corinne Savides Happel, MD, is a board-certified allergist and immunologist with a focus on allergic skin disorders, asthma, and other immune disorders. (verywellhealth.com)
- 2. The medical specialty dedicated to diagnosing and managing allergic disorders. (thefreedictionary.com)
- In developed countries, the prevalence and risk of allergic disorders have both steadily increased for decades ( 2 ). (spandidos-publications.com)
Types of hypersensitivity2
- Mechanisms, to the extent that they are currently understood, of other types of "hypersensitivity" reactions or intolerances, some mediated by antibodies other than IgE, and others by cells, are also discussed. (springer.com)
- however, other types of hypersensitivity also seem to be implicated. (hindawi.com)
- A patient with sensitization to aztreonam showed cross-reactivity to ceftazidime. (drugs.com)
- Cross-reactivity based on skin testing or in-vitro test occurs in up to 50% and 69% of cases, respectively. (hkmj.org)
- Recent international guidelines are in keeping with a low cross-reactivity rate. (hkmj.org)
- A personalised approach to cross-reactivity is advocated. (hkmj.org)
- 1 2 However, at least two recent reviews showed much lower cross-reactivity. (hkmj.org)
- 6 The 10% cross-reactivity rate has recently been questioned as a medical myth. (hkmj.org)
- 10 In order to minimise unnecessary exposure to expensive broad-spectrum antibiotics with higher toxicities and to preserve patients' right to receive commonly prescribed antibiotics, a better understanding of BL cross-reactivity is needed. (hkmj.org)
- Mechanism and epidemiology of cross-reactivity will be discussed, followed by a suggestion for a pragmatic approach. (hkmj.org)
- 11 Hence, antigenic similarity forms the basis of cross-reactivity. (hkmj.org)
- These hypersensitivity reactions to tetrazepam share no cross-reactivity with other benzodiazepines. (wikipedia.org)
- The lack of cross-reactivity with other benzodiazepines is believed to be due to the molecular structure of tetrazepam. (wikipedia.org)
- We describe the various types of glycopeptide hypersensitivity reactions associated with glycopeptides and lipoglycopeptides, including IgE-mediated reactions, RMS, and linear immunoglobulin A bullous dermatosis, as well as describe cross-reactivity with other glycopeptides. (mdpi.com)
- Other theories posit that women may develop progesterone hypersensitivity as a result of cross-reactivity with corticosteroids, which have similar molecular structures to hormones. (verywellhealth.com)
- Apparent cross-reactivity responses to sulfonamide-containing drugs likely represent multiple concurrent, rather than linked, drug hypersensitivities. (scielo.org.za)
- Although many references suggest that there is cross-reactivity between various sulfonamide medications, this has not been substantiated in the literature either from a structural framework (e.g. metabolism, chemical structure) or from a clinical standpoint. (scielo.org.za)
- Understanding the possible cross-reactivity will help a provider assess the risk to the patient and ultimately decide whether a nonpenicillin beta-lactam should be used. (pharmacytimes.com)
- In vitro data, skin tests, and patient challenge studies found no risk of cross-reactivity to other beta-lactam allergies. (pharmacytimes.com)
- therefore, the risk of cross-reactivity between these 2 agents exists and should be avoided. (pharmacytimes.com)
- They also stress that cross-reactivity among quinolones at both the IgE- and T-cell level is clinically well documented. (ingentaconnect.com)
- Extensive cross-reactivity exists between different penicillins. (phadia.com)
- Lacidipine should only be used with great care in patients with a previous allergic reaction to another dihydropyridine because there is a theoretical risk of cross-reactivity. (medicines.org.uk)
- But due to its high reactivity, orally ingested TODI will undergo spontaneous hydrolysis upon reaching the stomach as degradation products that are insoluble in water and thus TODI is not likely to cross gastrointestinal-tract membranes. (europa.eu)
- Various aspects of this syndrome, such as its clinical features, the cell types and mediators involved, the role of underlying chronic inflammatory processes, the patterns of cross-reactivity between NSAIDs, the major role of sulfidoleukotrienes (LTC4) and of some other mediators such as prostaglandin E2 (PGE2) and C5a are briefly reviewed. (cun.es)
- Relevance of allergenic sensitization to Cynodon dactylon and Phragmites communis: Cross-reactivity with Pooideae grasses. (allallergy.net)
Anticonvulsant hypersensitivity syndrome2
- 1,2 This syndrome was renamed anticonvulsant hypersensitivity syndrome in 1988, after observation of its occurrence with other anticonvulsants. (scielo.br)
- The original description of anticonvulsant hypersensitivity syndrome included occurrence of fever, cutaneous eruptions, leukocytosis and eosinophilia. (scielo.br)
- In this chapter, emphasis has been placed on the core mechanisms underlying the broad categories of hypersensitivity responses distinguished on the basis of the Gell and Coombs classification and based on differences in the immune reactants (antibodies or cells), the form of the presented antigen, and the effector mechanisms involved. (springer.com)
- The B-cells of an allergic person -- 'misinformed' at the genetic level -- cause the production of large quantities of IgE antibodies that attach themselves to mast cells and basophils throughout the body. (howstuffworks.com)
- Classic anaphylactic hypersensitivity is associated with the production of IgE antibodies synthesized by Beta cells upon exposure to appropriate antigen. (vetstream.com)
- Most food allergies in rats are often of a delayed hypersensitivity response. (ratguide.com)
- The revised nomenclature for allergies , which is based on the mechanisms that initiate and mediate hypersensitivity reactions, classifies such reactions to drugs as either allergic or non-allergic. (ingentaconnect.com)
- With these allergies, the reaction can involve the entire body. (howstuffworks.com)
- Examples of cytotoxic reaction are the Rh incompatibility of a newborn, blood transfusion reactions, and autoimmune diseases like Pemphigus Vulgaris, Bullous Pemphigoid, autoimmune hemolytic anemia and Goodpasture's syndrome to name a few. (dentalcare.com)
- The phenytoin (hydantoin) hypersensitivity syndrome is rare but potentially fatal. (bmj.com)
- Dose-dependent side-effects (neurological impairment, gingival hyperplasia and megaloblastic anaemia) soon became apparent but an idiosyncratic hypersensitivity syndrome to phenytoin (and other hydantoins) was first described in 1959. (bmj.com)
- We report a case of unrecognised, fatal, phenytoin hypersensitivity syndrome with characteristic pathological changes in the heart, liver, skin and lymph nodes at autopsy. (bmj.com)
- While vancomycin is relatively a safe agent adverse events include the "red man" syndrome, allergic reactions, and various bone marrow effects as well as nephrotoxicity. (frontiersin.org)
- Kounis syndrome has been established as a hypersensitivity coronary disorder induced by various conditions, drugs, environmental exposures, foods and coronary stents. (degruyter.com)
- Vasospastic allergic angina, allergic myocardial infarction and stent thrombosis with occluding thrombus infiltrated by eosinophils and/or mast cells constitute are the three reported, so far, variants of this syndrome. (degruyter.com)
- Kounis syndrome seems to be not a rare disease but an infrequently diagnosed clinical entity which has revealed that the same mediators released from the same inflammatory cells are also present and in acute coronary events of non allergic etiology. (degruyter.com)
- However, the detailed description of the "allergic angina syndrome" as coronary spasm, which represents a manifestation of endothelial dysfunction or microvascular angina and progresses to allergic acute myocardial infarction, was not described until 1991 [ 7 ]. (degruyter.com)
- This is the first case of Kounis syndrome with optical coherence tomography imaging and proven IgE wasp venom hypersensitivity. (bmj.com)
- Mild hypersensitivity reactions, such as rash, pruritus , and fever, have been reported and may necessitate discontinuation of ceftazidime (the active ingredient contained in Tazicef) A case of asthma induced by occupational exposure to ceftazidime has been reported. (drugs.com)
- In delayed hypersensitivity the allergic response occurs only after there has been repeated exposure to a food, or product, or antigen, that has been previously encountered. (ratguide.com)
- Allergic disease is caused by exposure to normally innocuous substances that activate mast cells. (spandidos-publications.com)
- depending on site of exposure, subsequent reactions can manifest as severe systemic disease or local skin reactions. (vetstream.com)
- History of prior exposure and reaction to an antigen. (vetstream.com)
- Cell-mediated reactions are initiated by T-lymphocytes and mediated by effector T-cells and macrophages. (dentalcare.com)
- In cell-mediated allergic reactions, CD4+ and CD8+ T cells recognize drugs through their αβ receptors. (ingentaconnect.com)
- The review by Schmid and coworkers analyzes the different pathogenic mechanisms involved in hypersensitivity reactions to quinolones, with special attention to T cell-mediated ones. (ingentaconnect.com)
- Our results thus indicate that AEPC inhibits mast cell‑mediated allergic inflammation by suppressing mast cell degranulation and the expression of pro-inflammatory cytokines caused by reduced intracellular calcium levels and the activation of NF-κB and p38 MAPK. (spandidos-publications.com)
- If an allergic reaction occurs, discontinue the drug. (nih.gov)
- Progesterone hypersensitivity occurs as a result of an allergic reaction to a woman's own progesterone and can also be caused by others sources of progestogen. (verywellhealth.com)
- If an allergic reaction occurs, Amoxicap 250 should be discontinued and the appropriate therapy instituted. (intekom.com)
- With IgE mediated reactions inflammatory mediators are released when a food antigen binds to a specific IgE antibody. (ratguide.com)
- In IgE-mediated reactions, the drug or drug metabolite reacts with IgE bound to the surface of mast cells and leads to the activation, degranulation, and release of mast-cell vasoactive mediators like histamine and tryptase. (ingentaconnect.com)
- Upon peanut consumption by an allergic individual, epitopes on peanut proteins bind and cross-link peanut-specific IgE on mast cell and basophil surfaces triggering the cells to release inflammatory mediators responsible for allergic reactions. (phys.org)
- Histamine, one of the major allergic mediators, plays a key role in various physiological and pathological responses, particularly allergic reactions ( 4 ). (spandidos-publications.com)
- other endogenous mediators are also generated at higher than normal levels during anaphylactic reactions, including the prostaglandins in interleukins. (vetstream.com)
- 2) An abnormal pharmacogenetic reaction to NSAIDs resulting in a hyperproduction of LTC4 and other mediators by activated mast cells, basophils and eosinophils. (cun.es)
- While less than 20% of all adverse drug reactions are immune mediated, it is common for a patient to give a history of being 'allergic' to an antimicrobial, usually penicillin. (allergy.org.au)
- Although hypersensitivity to glycopeptides is rare, both immune-mediated and delayed reactions have been reported in the literature. (mdpi.com)
- Acute allergic reactions have been reported. (intekom.com)
- examined specimens of coronary arteries from 20 patients who did not suffer from any kind of allergic disease but they had died of acute myocardial infarction and found that the degree of mast cell degranulation was much higher (200:1) at the sites of plaque erosion or rupture than in adjacent areas or in the more distant unaffected areas [ 8 ]. (degruyter.com)
- Drugs provide good examples of types II (immune hemolytic anemia, drug-induced thrombocytopenia) and III (serum sickness-like) hypersensitivities. (springer.com)
- Diagnostic work-ups for such reactions include skin tests, serum-specific IgE assays, flow cytometric basophil activation tests and, in case of negative responses to these in vivo and in vitro tests, controlled administrations of suspect antibiotics. (ingentaconnect.com)
- NSAID-induced hypersensitivity reactions (NHRs) have been reported in about 0.3% to 6% of the general population and are thought to account for 20% to 30% of all drug-related reactions, placing them second behind antibiotic-associated hypersensitivity reactions. (uspharmacist.com)
- There are many concerns about cross-allergenicity between sulfonamide antibiotics and non-antibiotic sulfonamide-containing drugs including the sulfones, and these concerns continue to complicate drug therapy. (scielo.org.za)
- 3 Patients will usually not experience the reaction again if re-exposed to the antibiotic when well. (bpac.org.nz)
- This can further lead to the induction or exacerbation of respiratory and/or cutaneous reactions. (uspharmacist.com)
- Drug-induced delayed-type cutaneous hypersensitivity reactions are mediated by CD4+ and CD8+ CD3+ T cells in the dermis and epidermis. (springer.com)
- Severe cutaneous adverse drug reactions generally require hospitalization, sometimes in intensive care or burns units, for observation of the vital signs and the visceral function. (scielo.br)
- We can define severe cutaneous adverse drug reactions (SCADR) as those that usually require hospitalization, often in intensive care or burns units, for meticulous observation of the vital signs and the function of internal organs. (scielo.br)
- Drug-specific T cells generate inflammatory reactions, mainly cutaneous, through the release of various cytokines (e.g., interleukin-5, interferon) and chemokines (e.g., interleukin-8). (ingentaconnect.com)
- There are about 20 proteins in this family of proteins, at least nine of which are involved in the allergic-response mechanism. (howstuffworks.com)
- Some allergic people become sensitized to proteins in such things as ragweed pollen, latex, certain foods, and drugs like penicillin. (howstuffworks.com)
- Here, we show that cross-linking Fc epsilon R1 on RBL-2H3 cells causes the tyrosine phosphorylation of at least 12 cellular proteins, including PLC gamma 1 (PLC gamma 1) and the receptor beta and gamma subunits. (asm.org)
- Hypersensitivity to quail egg proteins: what about hen egg? (allallergy.net)
Responsible for allergic reactions1
- Classification of allergic reactions responsible for clinical hypersensitivity and disease. (springer.com)
- Clinical presentation and time course in hypersensitivity reactions to β-lactams. (phadia.com)
- The clinical information available to FDA included significant numbers of reports of allergic and photoallergic skin reactions to PABA, with rates of PABA-induced skin reactions potentially 8 percent or higher. (cosmeticsinfo.org)
Cause allergic reactions2
- Mary Ann Lila and colleagues note that of the 170 foods that cause allergic reactions, peanuts can be the most dangerous. (phys.org)
- 7 A report from the National Academies of Sciences recommends that these nuts be removed from this list since there are little data on them and they uncommonly cause allergic reactions. (dovepress.com)
- Information for the community about allergic diseases, immunodeficiencies and other immune diseases. (allergy.org.au)
- Tissue damage present in autoimmune diseases (e.g., systemic lupus erythematosus), and chronic infectious diseases (e.g., leprosy) can be attributed, in part, to immune complex reactions. (dentalcare.com)
- Many chronic infectious diseases, including tuberculosis and fungal infections, exhibit delayed hypersensitivity. (dentalcare.com)
- Development of allergic diseases starts with a sensitization phase ( Figure 1 ). (jci.org)
- There are also studies concerning single nucleotide polymorphisms, which may be involved in multifactorial and multigenic diseases, and aimed at enabling patients at risk for hypersensitivity reactions to be identified. (ingentaconnect.com)
Mast cells and basophils1
- The introduction of penicillin for treatment of bacterial infections in the 1940s was immediately followed by reports of allergic reactions. (phadia.com)
- Accordingly, a broad range of health effects has been attributed to mold and dampness in indoor environments like systemic infections, allergic and hypersensitivity reactions, and irritant or toxic reactions contributing to respiratory, immune, and neurological effects ( 7 ). (frontiersin.org)
- Leukocyte degranulation is an important mechanism of host defense against invading microorganisms and a major contributing factor for allergic reaction. (jimmunol.org)
- An understanding of the regulatory mechanism of degranulation will help to promote innate immunity and reduce unwanted allergic reactions. (jimmunol.org)
- In mast cells, a mechanism of degranulation induced by FcεRI cross-linking involves recruitment and activation of the tyrosine kinases Lyn and Syk, phosphorylation of several tyrosine residues in FcεRI, activation of phospholipase Cγ (PLCγ), and generation of the second messengers diacylglycerol and inositol trisphosphate ( 1 , 15 ). (jimmunol.org)
- The exact mechanism for this reaction is unknown. (bpac.org.nz)
Patients who are allergic1
- Pregnancy can also result in sensitization to progesterone, and pregnancy can have significant effects on the immune system and can dramatically affect a variety of allergic conditions. (verywellhealth.com)
- Allergic sensitization and type I and IV hypersensitivity reactions. (jci.org)
- These processes form the basis of allergic sensitization. (jci.org)
- Key cellular and molecular players in allergic sensitization. (jci.org)
- In fact, hypersensitivity reactions to β-lactams may not be detected by tests performed only with penicillin determinants in cases where side-chain determinants play an important role in sensitization. (ingentaconnect.com)
- Cross-sectional study on allergic sensitization of Austrian adolescents using molecule-based IgE profiling. (allallergy.net)