Allantois: An extra-embryonic membranous sac derived from the YOLK SAC of REPTILES; BIRDS; and MAMMALS. It lies between two other extra-embryonic membranes, the AMNION and the CHORION. The allantois serves to store urinary wastes and mediate exchange of gas and nutrients for the developing embryo.Yolk Sac: The first of four extra-embryonic membranes to form during EMBRYOGENESIS. In REPTILES and BIRDS, it arises from endoderm and mesoderm to incorporate the EGG YOLK into the DIGESTIVE TRACT for nourishing the embryo. In placental MAMMALS, its nutritional function is vestigial; however, it is the source of INTESTINAL MUCOSA; BLOOD CELLS; and GERM CELLS. It is sometimes called the vitelline sac, which should not be confused with the VITELLINE MEMBRANE of the egg.Extraembryonic Membranes: The thin layers of tissue that surround the developing embryo. There are four extra-embryonic membranes commonly found in VERTEBRATES, such as REPTILES; BIRDS; and MAMMALS. They are the YOLK SAC, the ALLANTOIS, the AMNION, and the CHORION. These membranes provide protection and means to transport nutrients and wastes.Chorion: The outermost extra-embryonic membrane surrounding the developing embryo. In REPTILES and BIRDS, it adheres to the shell and allows exchange of gases between the egg and its environment. In MAMMALS, the chorion evolves into the fetal contribution of the PLACENTA.Primitive Streak: A linear band of rapidly proliferating cells that begins near the posterior end of an embryo and grows cranially. Primitive streak is formed during GASTRULATION by the convergent migration of primary ectodermal cells (EPIBLAST). The knot at the tip of the streak is called HENSEN NODE.Mesoderm: The middle germ layer of an embryo derived from three paired mesenchymal aggregates along the neural tube.Blood Vessels: Any of the tubular vessels conveying the blood (arteries, arterioles, capillaries, venules, and veins).Embryo, Mammalian: The entity of a developing mammal (MAMMALS), generally from the cleavage of a ZYGOTE to the end of embryonic differentiation of basic structures. For the human embryo, this represents the first two months of intrauterine development preceding the stages of the FETUS.Germ Cells: The reproductive cells in multicellular organisms at various stages during GAMETOGENESIS.Embryonic and Fetal Development: Morphological and physiological development of EMBRYOS or FETUSES.Placenta: A highly vascularized mammalian fetal-maternal organ and major site of transport of oxygen, nutrients, and fetal waste products. It includes a fetal portion (CHORIONIC VILLI) derived from TROPHOBLASTS and a maternal portion (DECIDUA) derived from the uterine ENDOMETRIUM. The placenta produces an array of steroid, protein and peptide hormones (PLACENTAL HORMONES).T-Box Domain Proteins: Proteins containing a region of conserved sequence, about 200 amino acids long, which encodes a particular sequence specific DNA binding domain (the T-box domain). These proteins are transcription factors that control developmental pathways. The prototype of this family is the mouse Brachyury (or T) gene product.Amnion: The innermost membranous sac that surrounds and protects the developing embryo which is bathed in the AMNIOTIC FLUID. Amnion cells are secretory EPITHELIAL CELLS and contribute to the amniotic fluid.Coturnix: A genus of BIRDS in the family Phasianidae, order GALLIFORMES, containing the common European and other Old World QUAIL.Gene Expression Regulation, Developmental: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action during the developmental stages of an organism.In Situ Hybridization: A technique that localizes specific nucleic acid sequences within intact chromosomes, eukaryotic cells, or bacterial cells through the use of specific nucleic acid-labeled probes.Epithelium: One or more layers of EPITHELIAL CELLS, supported by the basal lamina, which covers the inner or outer surfaces of the body.Gastrula: The developmental stage that follows BLASTULA or BLASTOCYST. It is characterized by the morphogenetic cell movements including invagination, ingression, and involution. Gastrulation begins with the formation of the PRIMITIVE STREAK, and ends with the formation of three GERM LAYERS, the body plan of the mature organism.Embryonic Development: Morphological and physiological development of EMBRYOS.Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.Receptors, Growth Factor: Cell surface receptors that bind growth or trophic factors with high affinity, triggering intracellular responses which influence the growth, differentiation, or survival of cells.

Mrj encodes a DnaJ-related co-chaperone that is essential for murine placental development. (1/343)

We have identified a novel gene in a gene trap screen that encodes a protein related to the DnaJ co-chaperone in E. coli. The gene, named Mrj (mammalian relative of DnaJ) was expressed throughout development in both the embryo and placenta. Within the placenta, expression was particularly high in trophoblast giant cells but moderate levels were also observed in trophoblast cells of the chorion at embryonic day 8.5, and later in the labyrinth which arises from the attachment of the chorion to the allantois (a process called chorioallantoic fusion). Insertion of the ROSAbetageo gene trap vector into the Mrj gene created a null allele. Homozygous Mrj mutants died at mid-gestation due to a failure of chorioallantoic fusion at embryonic day 8.5, which precluded formation of the mature placenta. At embryonic day 8.5, the chorion in mutants was morphologically normal and expressed the cell adhesion molecule beta4 integrin that is known to be required for chorioallantoic fusion. However, expression of the chorionic trophoblast-specific transcription factor genes Err2 and Gcm1 was significantly reduced. The mutants showed no abnormal phenotypes in other trophoblast cell types or in the embryo proper. This study indicates a previously unsuspected role for chaperone proteins in placental development and represents the first genetic analysis of DnaJ-related protein function in higher eukaryotes. Based on a survey of EST databases representing different mouse tissues and embryonic stages, there are 40 or more DnaJ-related genes in mammals. In addition to Mrj, at least two of these genes are also expressed in the developing mouse placenta. The specificity of the developmental defect in Mrj mutants suggests that each of these genes may have unique tissue and cellular activities.  (+info)

Canine preprorelaxin: nucleic acid sequence and localization within the canine placenta. (2/343)

Employing uteroplacental tissue at Day 35 of gestation, we determined the nucleic acid sequence of canine preprorelaxin using reverse transcription- and rapid amplification of cDNA ends-polymerase chain reaction. Canine preprorelaxin cDNA consisted of 534 base pairs encoding a protein of 177 amino acids with a signal peptide of 25 amino acids (aa), a B domain of 35 aa, a C domain of 93 aa, and an A domain of 24 aa. The putative receptor binding region in the N'-terminal part of the canine relaxin B domain GRDYVR contained two substitutions from the classical motif (E-->D and L-->Y). Canine preprorelaxin shared highest homology with porcine and equine preprorelaxin. Northern analysis revealed a 1-kilobase transcript present in total RNA of canine uteroplacental tissue but not of kidney tissue. Uteroplacental tissue from two bitches each at Days 30 and 35 of gestation were studied by in situ hybridization to localize relaxin mRNA. Immunohistochemistry for relaxin, cytokeratin, vimentin, and von Willebrand factor was performed on uteroplacental tissue at Day 30 of gestation. The basal cell layer at the core of the chorionic villi was devoid of relaxin mRNA and immunoreactive relaxin or vimentin but was immunopositive for cytokeratin and identified as cytotrophoblast cells. The cell layer surrounding the chorionic villi displayed specific hybridization signals for relaxin mRNA and immunoreactivity for relaxin and cytokeratin but not for vimentin, and was identified as syncytiotrophoblast. Those areas of the chorioallantoic tissue with most intense relaxin immunoreactivity were highly vascularized as demonstrated by immunoreactive von Willebrand factor expressed on vascular endothelium. The uterine glands and nonplacental uterine areas of the canine zonary girdle placenta were devoid of relaxin mRNA and relaxin. We conclude that the syncytiotrophoblast is the source of relaxin in the canine placenta.  (+info)

Cortisol in fetal fluids and the fetal adrenal at parturition in the tammar wallaby (Macropus eugenii). (3/343)

Glucocorticoid hormones may play a critical role in initiating parturition in tammar wallabies. In this study, we investigated the concentration of cortisol in fetal fluids and cortisol production by fetal adrenals over the last 3 days of the 26-day pregnancy and within 24 h postpartum. The fetal adrenals almost doubled in size between Days 24 and 26 of pregnancy, and their cortisol content increased over 10-fold during this period, from 10 pg to over 100 pg per adrenal pair. After birth, neonatal adrenals continued to grow, but cortisol content fell dramatically to 20 pg. The prepartum increase in adrenal cortisol was reflected by a substantial rise in cortisol concentrations in yolk sac fluid, allantoic fluid, and fetal blood, which were below 10 ng/ml on Day 24 and rose to over 40 ng/ml by Day 26. Cortisol concentrations in neonatal blood decreased postpartum, mirroring decreased cortisol content in neonatal adrenals. Cortisol production by the fetal adrenal was stimulated in vitro by ACTH and prostaglandin E2, suggesting that the in vivo increase may be stimulated by release of ACTH from the fetal hypothalamic-pituitary axis and prostaglandin E2 from the placenta. These results indicate that increasing cortisol production by the fetal adrenal is a characteristic of late pregnancy in the tammar wallaby and support the suggestion that fetal cortisol may trigger the initiation of parturition in this marsupial species.  (+info)

Bmp4 is required for the generation of primordial germ cells in the mouse embryo. (4/343)

In many organisms the allocation of primordial germ cells (PGCs) is determined by the inheritance of maternal factors deposited in the egg. However, in mammals, inductive cell interactions are required around gastrulation to establish the germ line. Here, we show that Bmp4 homozygous null embryos contain no PGCs. They also lack an allantois, an extraembryonic mesodermal tissue derived, like the PGCs, from precursors in the proximal epiblast. Heterozygotes have fewer PGCs than normal, due to a reduction in the size of the founding population and not to an effect on its subsequent expansion. Analysis of beta-galactosidase activity in Bmp4(lacZneo) embryos reveals that prior to gastrulation, Bmp4 is expressed in the extraembryonic ectoderm. Later, Bmp4 is expressed in the extraembryonic mesoderm, but not in PGCs. Chimera analysis indicates that it is the Bmp4 expression in the extraembryonic ectoderm that regulates the formation of allantois and primordial germ cell precursors, and the size of the founding population of PGCs. The initiation of the germ line in the mouse therefore depends on a secreted signal from the previously segregated, extraembryonic, trophectoderm lineage.  (+info)

Identification of endothelial cell binding sites on the laminin gamma 1 chain. (5/343)

The laminins belong to a family of trimeric basement membrane glycoproteins with multiple domains, structures, and functions. Endothelial cells bind laminin-1 and form capillary-like structures when plated on a laminin-1-rich basement membrane matrix, Matrigel. Laminin-1 is composed of 3 chains, alpha1, beta1, and gamma1. Because laminin-1 is known to contain multiple biologically active sites, we have screened 156 synthetic overlapping peptides spanning the entire laminin gamma1 chain for potential angiogenic sequences. Only 7 of these peptides, designated as C16, C25, C30, C38, C64, C75, and C102, disrupted the formation of capillary-like structures by human umbilical vein endothelial cells on Matrigel. Dose-response experiments in the presence of 50 to 200 microg/mL showed that tube formation was prevented by most peptides at 150 and 200 microg/mL, except for C16, which showed strong activity at all concentrations. Active peptides promoted vessel sprouting from aorta rings and angiogenesis in the chick chorioallantoic membrane assay. In addition, the active peptides also promoted endothelial cell adhesion to dishes coated with 0.1 microg of peptide and inhibited attachment to laminin-1 but not to plastic or fibronectin. Four of the active peptides, C25, C38, C75, and C102, may have cell-type specificity with endothelial cells, since they did not promote PC12 neurite outgrowth or adhesion of B16-F10 melanoma and human submandibular gland cells. These results suggest that specific laminin gamma1-chain peptides have angiogenic activity with potential therapeutic applications.  (+info)

Human erythropoietin induces a pro-angiogenic phenotype in cultured endothelial cells and stimulates neovascularization in vivo. (6/343)

Hematopoietic and endothelial cell lineages share common progenitors. Accordingly, cytokines formerly thought to be specific for the hematopoietic system have been shown to affect several functions in endothelial cells, including angiogenesis. In this study, we investigated the angiogenic potential of erythropoietin (Epo), the main hormone regulating proliferation, differentiation, and survival of erythroid cells. Epo receptors (EpoRs) have been identified in the human EA.hy926 endothelial cell line by Western blot analysis. Also, recombinant human Epo (rHuEpo) stimulates Janus Kinase-2 (JAK-2) phosphorylation, cell proliferation, and matrix metalloproteinase-2 (MMP-2) production in EA.hy926 cells and significantly enhances their differentiation into vascular structures when seeded on Matrigel. In vivo, rHuEpo induces a potent angiogenic response in the chick embryo chorioallantoic membrane (CAM). Accordingly, endothelial cells of the CAM vasculature express EpoRs, as shown by immunostaining with an anti-EpoR antibody. The angiogenic response of CAM blood vessels to rHuEpo was comparable to that elicited by the prototypic angiogenic cytokine basic fibroblast growth factor (FGF2), it occurred in the absence of a significant mononuclear cell infiltrate, and it was not mimicked by endothelin-1 (ET-1) treatment. Taken together, these data demonstrate the ability of Epo to interact directly with endothelial cells and to elicit an angiogenic response in vitro and in vivo and thus act as a bona fide direct angiogenic factor.  (+info)

Purine analogue 6-methylmercaptopurine riboside inhibits early and late phases of the angiogenesis process. (7/343)

Angiogenesis has been identified as an important target for antineoplastic therapy. The use of purine analogue antimetabolites in combination chemotherapy of solid tumors has been proposed. To assess the possibility that selected purine analogues may affect tumor neovascularization, 6-methylmercaptopurine riboside (6-MMPR), 6-methylmercaptopurine, 2-aminopurine, and adenosine were evaluated for the capacity to inhibit angiogenesis in vitro and in vivo. 6-MMPR inhibited fibroblast growth factor-2 (FGF2)-induced proliferation and delayed the repair of mechanically wounded monolayer in endothelial GM 7373 cell cultures. 6-MMPR also inhibited the formation of solid sprouts within fibrin gel by FGF2-treated murine brain microvascular endothelial cells and the formation of capillary-like structures on Matrigel by murine aortic endothelial cells transfected with FGF2 cDNA. 6-MMPR affected FGF2-induced intracellular signaling in murine aortic endothelial cells by inhibiting the phosphorylation of extracellular signal-regulated kinase-2. The other molecules were ineffective in all of the assays. In vivo, 6-MMPR inhibited vascularization in the chick embryo chorioallantoic membrane and prevented blood vessel formation induced by human endometrial adenocarcinoma specimens grafted onto the chorioallantoic membrane. Also, topical administration of 6-MMPR caused the regression of newly formed blood vessels in the rabbit cornea. Thus, 6-MMPR specifically inhibits both the early and the late phases of the angiogenesis process in vitro and exerts a potent anti-angiogenic activity in vivo. These results provide a new rationale for the use of selected purine analogues in combination therapy of solid cancer.  (+info)

Functional involvement of carbonic anhydrase in calcium transport of the chick chorioallantoic membrane. (8/343)

Carbonic anhydrase activity was demonstrated in the chick-embryonic chorioallantoic membrane and was correlated with the Ca2+-transport activity of the membrane. It is inhibited by sulphonamides and is expressed in the chorioallantoic membrane in an age-dependent fashion during embryonic development. Ca2+ uptake by the chorioallantoic membrane in vivo also increases in a similar age-dependent manner. The temporal increase in these activities is coincident with calcium deposition in the embryonic skeleton. Incubation of the chorioallantoic membrane in ovo with sulphonamides specifically inhibits both the carbonic anhydrase and the Ca2+ uptake activities of the membrane in vivo. Enzyme histochemistry revealed the carbonic anhydrase activity is localized in the Ca2+-transporting ectodermal cells of the chorioallantoic membrane. These results, taken together, indicate that carbonic anhydrase may be functionally important in the Ca2+-transport activity of the chorioallantoic membrane.  (+info)

*Allantois

The allantois (/əˈlæntɔɪs/; plural allantoides or allantoises) is a hollow sac-like structure filled with clear fluid that ... Also, most marsupial allantoises do not fuse with the chorion. An exception is the allantois of the bandicoot, which has a ... "Allantois". dictionary.com. Downs, K.M. 1998. "The Murine Allantois". Current Topics in Developmental Biology vol. 39, pp 1-33 ... Oxygen is absorbed by the allantois through the egg shell. In most marsupials, the allantois is avascular, having no blood ...

*Amniotic sac

On the outer side, the amniotic sac is connected to the yolk sac, the allantois and, via the umbilical cord, to the placenta. ...

*Wilhelm Krause

Ueber die Allantois des Menschen, 1875. Handbuch der menschlichen Anatomie. (Third edition of his father's work) 3 volumes; ...

*Reptiliomorpha

A very small allantois is found in modern amphibians. Later came the amnion surrounding the fetus proper, and the chorion, ... The first to evolve was probably the allantois, a sack that develops from the gut/yolk-sack. This sack contains the embryo's ... encompassing the amnion, allantois, and yolk-sack. Exactly where the border between reptile-like amphibians (non-amniote ...

*Reptile

The allantois (8) is a sac that collects the metabolic waste produced by the embryo. The amniotic sac (10) contains amniotic ... An amnion, chorion, and allantois are present during embryonic life. The eggshell (1) protects the crocodile embryo (11) and ...

*Development of the urinary system

In other words, the allantois takes no share in its formation. After the separation of the rectum from the dorsal part of the ... The vesico-urethral portion is the deepest, continuous with the allantois. It absorbs the ends of the Wolffian ducts and the ...

*Chorion

To compensate for this, the chorion and the allantois fuse together to form the chorioallantoic membrane. Together these form a ... Diagram illustrating early formation of allantois and differentiation of body-stalk. Diagram showing later stage of allantoic ...

*Development of the reproductive system

The vesico-urethral portion is the deepest portion, continuous with the allantois. It absorbs the ends of the mesonephric ducts ...

*Urachal cyst

A urachal cyst is a sinus remaining from the allantois during embryogenesis. It is a cyst which occurs in the remnants between ...

*Fetal membrane

The other fetal membranes are the allantois and the secondary umbilical vesicle. UpToDate Patient Preview > Fetal membranes: ...

*Development of the gonads

Germ cells migrate from near the allantois and colonize the primordial gonads. In the female, the germ cells colonise the ...

*Umbilical cord

The umbilical cord develops from and contains remnants of the yolk sac and allantois. It forms by the fifth week of development ...

*TBX4

... has been shown to be expressed in the allantois, hindlimb, lung and proctodeum. Expression of Tbx4 is required for ... Additionally, embryos with the Tbx4-mutant gene were observed to have allantoises that were apoptotic, stunted, and displayed ... "Loss of Tbx4 Blocks Hindlimb Development and Affects Vascularization and Fusion of the Allantois."Development. The Company of ... "Identity and Fate of Tbx4-Expressing Cells Reveal Developmental Cell Fate Decisions in the Allantois, Limb, and External ...

*Placenta

... l mammals, such as humans, have a chorioallantoic placenta that forms from the chorion and allantois. In humans, the ...

*Callophrys xami

In Mexico, Echevelia gibbiflora and Sedum allantoides are the most common host plants. The role of host plants is integral to ...

*Embryo drawing

Haeckel speculates that the allantois is formed in a similar way in both humans and other mammals. His, on the other hand, ... Although Haeckel is proven right about the allantois, the utilization of Krause's embryo as justification turns out to be ...

*Urinary bladder

The human urinary bladder derives from the urogenital sinus, and it is initially continuous with the allantois. The upper and ...

*Cloaca (embryology)

The hind-gut is at first prolonged backward into the body-stalk as the tube of the allantois; but, with the growth and flexure ... and consequently a bend is formed at the junction of the hind-gut and allantois. This bend becomes dilated into a pouch, which ... constitutes the endodermal cloaca; into its dorsal part the hind-gut opens, and from its ventral part the allantois passes ...

*Blood islands

... arise external to the developing embryo on the umbilical vesicle, allantois, connecting stalk and chorion. They ... They develop from undifferentiated hemangioblasts in blood vessels in the walls of the umbilical vesicle, allantois and chorion ...

*Excretory system

Embryologically, the bladder is derived from the urogenital sinus, and it is initially continuous with the allantois. In human ...

*Retinol-binding protein

RBP mRNA was localized to epithelial cells of the chorion, allantois, and amnion at day 45 of pregnancy. Lastly, RBP mRNA was ...

*Hematopoietic stem cell niche

Mice have also shown hematopoietic activity in the umbilical arteries and the allantois, in which HSCs and endothelial cells ... Inman KE, Downs KM (2007). "The murine allantois: emerging paradigms in development of the mammalian umbilical cord and its ...

*2009 flu pandemic vaccine

The virus replicates within the allantois of the embryo, which is the equivalent of the placenta in mammals. The fluid in this ...

*Yolk sac

1 Placental villi 2 Yolk-sac 3 Umbilical cord 4 Allantois 5 Heart 6 Digestive tube 7 Embryo 8 Amniotic cavity The yolk sac can ... 1 Heart 2 Amniotic cavity 3 Embryo 4 Body-stalk 5 Placental villi 6 Allantois 7 Yolk-sac 8 Chorion Diagram illustrating a later ... 1 Amniotic cavity 2 Body-stalk 3 Allantois 4 Yolk-sac 5 Chorion Diagram showing later stage of allantoic development with ... 1 - Amniotic cavity 2 - Yolk-sac 3 - Chorion Diagram illustrating early formation of allantois and differentiation of body- ...

*Urethra

The first of these is the cranial portion which is continuous with the allantois and forms the bladder proper. In the male the ...
Synonyms for allantois adenomatous dysplasia in Free Thesaurus. Antonyms for allantois adenomatous dysplasia. 3 words related to allantois: mammal, mammalian, fetal membrane. What are synonyms for allantois adenomatous dysplasia?
The allantois (/əˈlæntɔɪs/; plural allantoides or allantoises) is a hollow sac-like structure filled with clear fluid that forms part of a developing amniotes conceptus (which consists of all embryonic and extra-embryonic tissues). It helps the embryo exchange gases and handle liquid waste. The allantois, along with the amnion and chorion (other extraembryonic membranes), identify humans and other mammals as well as reptiles, dinosaurs, and birds as amniotes. Of the vertebrates, only the anamniotes (fish and amphibians) lack this structure. This sac-like structure, whose name is the New Latin equivalent of "sausage" (in reference to its shape when first formed) is primarily involved in nutrition and excretion, and is webbed with blood vessels. The function of the allantois is to collect liquid waste from the embryo, as well as to exchange gases used by the embryo. The structure first evolved in reptiles and birds as a reservoir for nitrogenous waste, and also as a means for oxygenation of ...
Acetylcholinesterase Inhibitors Promote Angiogenesis in Chick Chorioallantoic Membrane and Inhibit Apoptosis of Endothelial Cells. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
Allantois definition, a vascular, extraembryonic membrane of birds, reptiles, and certain mammals that develops as a sac or diverticulum from the ventral wall of the hindgut. See more.
(R,R)ZX-5 is a NO regulatory compound, which could significantly increase choroidal blood flow in New Zealand rabbit. The aim of this paper is to investigate the molecular mechanism of (R,R)ZX-5 promoting NO production. Besides this, we also investigated the antiangiogenic activity of (R,R)ZX-5. Analysis of Western blot showed that (R,R)ZX-5 up-regulated the expression of Akt, p-Akt (Thr473), eNOS and p-eNOS (Ser1177), down-regulated the expression of Cyclin D1 in human retinal endothelial cells and escalated the intracellular free Ca2+ concentration. Additionally, (R,R)ZX-5 inhibited the growth of blood vessels in the chick chorioallantoic membrane model. It is concluded that (R,R)ZX-5 promotes choroidal blood flow through PI3K/Akt-eNOS and Akt-Ca2+-eNOS pathways. Additionally, (R,R)ZX-5 can inhibit angiogenesis.
Transcription factor NRF2 is an important modifier of cellular responses to oxidative stress. Although its cytoprotective effects are firmly established, recent evidence suggesting important roles in cancer pathobiology has yet to be mechanistically developed. In the current study, we investigated the role of NRF2 in colon tumor angiogenesis. Stable RNAi-mediated knockdown of NRF2 in human colon cancer cells suppressed tumor growth in mouse xenograft settings with a concomitant reduction in blood vessel formation and VEGF expression. Similar anti-angiogenic effects of NRF2 knockdown were documented in chick chorioallantoic membrane assays and endothelial tube formation assays. Notably, NRF2-inhibited cancer cells failed to accumulate HIF-1αprotein under hypoxic conditions, limiting expression of VEGF and other HIF-1α target genes. In these cells, HIF-1α was hydroxylated but pharmacological inhibition of PHD domain-containing prolyl hydroxylases was sufficient to restore hypoxia-induced ...
Explaination: Explanation: Placenta and chorion compose the fetal-maternal junction. The former is a trophoblast derivative and the latter is a derivative of both trophoblast and extraembryonic mesoderm. The other extraembryonic tissues such as the amnion, the yolk sac and the allantois are derived from the inner cell mass. Among them, the yolk sac and the allantois are endodermal derivatives whereas the amnion is an ectodermal derivative ...
Therapeutic regulation of tissue vascularization has appeared as an attractive approach to treat a number of human diseases. In vivo neovascularization assays that reflect physiological and pathological formation of neovessels are important in this effort. In this report we present an assay where the effects of activators and inhibitors of angiogenesis can be quantitatively and qualitatively measured. A provisional matrix composed of collagen I and fibrin was formed in a plastic cylinder and implanted onto the chick chorioallantoic membrane. A nylon mesh separated the implanted matrix from the underlying tissue to distinguish new from pre-existing vessels. Vascularization of the matrix in response to fibroblast growth factor-2 or platelet-derived growth factor-BB was scored in a double-blinded manner, or vessel density was measured using a semi-automated image analysis procedure. Thalidomide, fumagillin, U0126 and TGFβ inhibited neovessel growth while hydrocortisone exerted a negative and ...
J:31267 Spindle A, Sturm KS, Flannery M, Meneses JJ, Wu K, Pedersen RA, Defective chorioallantoic fusion in mid-gestation lethality of parthenogenone
Term: eclampsia Origin: Anc Greek εκ /ec(=forth)+ λάμπω /lampo(=to shine) Literally meaning: shine forth Coined: In 1619 in treat ...
Term: tryptophan (Trp W) Literally meaning: "to be broken and to appear" Origin: Anc Greek τρίβω / trivo (=to rub, to powder, to gr ...
When few membranes are produced by mother, it should take more care for their survival. If the number are more, care will be less. In amniotes when the developing embryo is enveloped, by extra embryonic membranes, which will give scope, for developing embryo, the extra em-bryonic membranes are chorion, amnion, yolk sac, allantois. ...
Define allantois: a vascular fetal membrane of reptiles, birds, and mammals that is formed as a pouch from the hindgut and that in placental mammals …
BioAssay record AID 52868 submitted by ChEMBL: Compound was tested for antiangiogenic activity in chick embryo chorioallantoic membrane (CAM) assay system at 10 ug/egg dose; No of CAM avascular/total=4/16(25%).
Angiogenesis is the process of formation of new blood vessels from pre-existing vessels or endothelial cell progenitors. It plays a crucial role in tumor growth and metastasis. Tumor angiogenesis have been widely studied as an important target for suppressing tumor growth and metastasis. Here, we describe an in vivo chick embryo chorioallantoic membrane (CAM) model. The chick embryo chorioallantoic membrane is an extraembryonic and is rich of blood vessels. After exposing the vascular zone of the CAM, a sterilized filter-paper disk is employed, which is used as a carrier for being loaded with various chemicals, drugs or virus. Finally, the CAM was fixed and spread on glass slide, and the blood vessels were quantified by counting the number of blood vessel branch points. Compared with the matrigel plug angiogenesis assay, in which tumor cells are mixed with the matrigel gel (expensive) and injected into the mice, subsequently using immunohistochemistry (IHC) staining (time consuming) with the endothelial
Looking for online definition of allantois adenomatous dysplasia in the Medical Dictionary? allantois adenomatous dysplasia explanation free. What is allantois adenomatous dysplasia? Meaning of allantois adenomatous dysplasia medical term. What does allantois adenomatous dysplasia mean?
The chorioallantoic membrane - also called the chorioallantois or abbreviated to CAM - is a vascular membrane found in eggs of some amniotes, such as birds and reptiles. It is formed by the fusion of the mesodermal layers of two developmental structures: the allantois and the chorion.[1] In mammals, this structure forms the placenta. Three different layers compose the chorioallantoic membrane; these are called the chorionic epithelium, the mesenchyme and the allantoic epithelium. Blood capillaries and sinuses are found between epithelial cells of the chorionic layer, allowing close contact (within 0.2 μm) with air found in pores of the shell membrane of the egg.[2] As a result, the chorioallantoic membrane allows exchange of gases, such as oxygen, to developing embryos.[1] During embryonic development of birds, the chorioallantoic membrane also plays an essential role in bone formation by transporting calcium into the embryo from the eggshell.[1] Chorioallantoic membranes from developing ...
The majority of ovarian cancer patients present with advanced disease and despite aggressive treatment, prognosis remains poor. Significant improvement in ovarian cancer survival will require the development of more effective molecularly targeted therapeutics. Commonly, mouse models are used for the in vivo assessment of potential new therapeutic targets in ovarian cancer. However, animal models are costly and time consuming. Other models, such as the chick embryo chorioallantoic membrane (CAM) assay, are therefore an attractive alternative. CAM assays have been widely used to study angiogenesis and tumor invasion of colorectal, prostate and brain cancers. However, there have been limited studies that have used CAM assays to assess ovarian cancer invasion and metastasis. We have therefore developed a CAM assay protocol to monitor the metastatic properties of ovarian cancer cells (OVCAR-3, SKOV-3 and OV-90) and to study the effect of potential therapeutic molecules in vivo. The results from the CAM assay
Angiogenic potential of the cerebrospinal fluid (CSF) of patients with high-grade gliomas measured with the chick embryo chorioallantoic membrane assay (CAM) ...
Rigorous and systematic pre-clinical studies are necessary and essential to establish the efficacy and safety of Oriental herbs and formulas in order to transform traditional herbal practices into evidence-based medicine. Here we evaluated the anti-cancer activities of the ethanol extract of Ka-mi-kae-kyuk-tang (KMKKT), a formula of ten Oriental herbs, with a battery of in vitro and in vivo mechanism-based biomarkers involving angiogenesis, apoptosis and metastasis. The results show that KMKKT suppressed the vascular endothelial responses by inhibiting basic fibroblast growth factor (bFGF)-induced ERK1/2 phosphorylation, cell migration as well as tube formation in the human umbilical vein endothelial cell model, and decreased the hypoxia-induced HIF1α and vascular epithelial growth factor (VEGF) expression in the mouse Lewis lung carcinoma (LLC) cells in vitro, and inhibited the bFGF-induced angiogenesis in chick chorioallantoic membrane model, and in the Matrigel plugs in mice. Intraperitoneal ...
The aims of this work are to study the antitumor effect of the adeno-associated virus on the xenografted tumors of chick embryo chorioallantoic membrane and predict potential genes and biological pathways which are associated with renal cell carcinoma. The adeno-associated virus NT4-TAT-6 × His-VHLbeta was constructed and identified. Then, chick embryos with xenografted tumor were divided into three groups and respectively inoculated with rAAV/NT4-TAT-6 × His-VHLbeta (group A), empty virus (group B), and phosphate-buffered saline (group C, the control subject). Antitumor effect in each group was investigated by means of immunofluorescence observation. Genes interacted with von Hippel-Lindau were screened by Search Tool for the Retrieval of Interacting Genes/Proteins database, while pathway analysis were performed based on Kyoto Encyclopedia of Genes and Genomes. The growth of xenografted tumors inoculated with recombinant adeno-associated virus was slower than the control subjects. The tumor ...
The overall objectives of this thesis were to develop a short-term culture system and to examine the effects of vitrification and short-term culture on the viability of fresh and vitrified bovine ovarian tissue and the follicles within. The first objective was to compare the health and development of preantral follicles in bovine ovarian tissue, as well as the neovascularization of these tissues, subjected to avian chorioallantoic membrane (CAM) culture with the traditional in vitro culture system. We hypothesized that the chorioallantoic membrane (CAM) of the chicken embryo is a more suitable culture system than traditional in vitro culture. Bovine ovaries were retrieved from a local abattoir and cortical pieces (1-2mm3) were randomly assigned to one of the following groups; control (fixed immediately), CAM or in in vitro culture. Ovarian tissue fragments from both groups were removed on D1, D3 and D5 of culture, fixed, sectioned (5μm) and stained with H&E. The numbers of healthy and ...
We have previously shown that angiotensinogen, like other members of the serine protease inhibitor (serpins) family has anti-angiogenic properties in vitro on cultured endothelial cells and in ovo in the chick chorioallantoic membrane assay. By staining blood vessels of histological sections of the chick-chorioallantoic membrane with an endothelial-specific cell marker lectin we quantified vessel density in angiotensinogen treated areas and control areas: 48 hours after angiotensinogen was locally applied on the chick-chorioallantoic membrane we observed a 70% decrease in mesodermic vessel density in comparison to the control sections. Human angiotensinogen transfected chinese-hamster-ovary-cells grafted onto the surface of the chick-chorioallantoic membrane for 48 hours and constantly producing and secreting human angiotensinogen are leading to a similar decrease in vessel density of mesodermal blood vessels in comparison to non-transfected cells. As human angiotensinogen does not interact ...
When a suspension of living adult chick leucocytes is placed in contact with the chorioallantoic membrane (CAM) of a developing chick embryo, a variable number of white focal lesions appear a few days later. The number of foci is positively correlated with the number of cells in the inoculum. The phenomenon is known to be an expression of an immunological reaction of the grafted cells against the host. F. M. Burnet and his colleagues have suggested that each focus results from the immunological activity of one and only one cell. If this presumption were confirmed the CAM system would gain in usefulness, in particular for the isolation of clones of immunologically competent cells. In the present work this single-hit hypothesis has been subjected to a specific test of its biometrical consequences. On the single-hit model the response should be proportional to the dose. Equivalently, on the logarithmic scale of measurement adopted in these experiments, the fitted dose-response line should show a ...
The authors studied the specific tumor antigen in Crockers sarcoma of mice and M-1 sarcoma of rats as well as in heterotransplants of these tumors on the chorioallantoic membrane of the developing...
Our results indicate that TSC progenitors are distributed widely in the ExE, and then the ChE, prior to fusion with the EPC, on the basis of the non-local distribution of TSC colonies and lines in vitro (Table 1 and Table 2), and mitoses in vivo (Fig. 6A and Table 5). These findings are supported by the pattern of ExE cell division that revealed that labelled sister cells were frequently not immediately adjacent to each other (Fig. 2 and Table 3), indicating that considerable cell mixing and dispersal occurs during growth of the ExE/ChE.. The apparent non-coherence of ExE growth invites the suggestion that TSC progenitors originate in the proximal third adjacent to the epiblast, and become displaced distally upon division. However, this is unlikely as the ExE third abutting the epiblast, a region intensely expressing the diploid markers: Cdx2 (Beck et al., 1995), Err2 (Pettersson et al., 1996) and Eomes (Ciruna and Rossant, 1999) did not produce a significantly higher percentage of TSC colonies ...
537 The expression of matrix metalloproteinases (MMPs) plays crucial roles in cancer progression and metastasis. This study is to clarify whether MMP associates with radiation-accelerated pulmonary metastasis of Lewis lung carcinoma (LLC-LM) in C57BL/6 mouse model. By using in vitro matrigel-coated Boyden chamber invasion assay, non-cytotoxic dose of radiation (7.5 Gy) significantly enhanced LLC-LM cell invasiveness. Irradiated LLC-LM cells showed the increased intravasation capability in the chicken chorioallantoic membrane assay. To test MMP family protein gene expression in irradiated LLC-LM cells, MMP-9 gene expression was significantly enhanced in both transcriptional and translational levels, so was the enzyme activity in the culture supernatant. The use of anti-sense MMP-9 oligonucleotides significantly inhibited the in vitro radiation-enhanced invasiveness. With 1 x 106 MMP-9 RNAi stably transfected LLC-LM cells injected subcutaneously in the right thighs of C57BL/6 mice and irradiated ...
Definition of chorioallantoic placenta. Provided by Stedmans medical dictionary and Drugs.com. Includes medical terms and definitions.
A swept source based Fourier domain optical Doppler tomography (FDODT) system was developed. The technique is based on a phase-resolved method where phase information was retrieved from the reconstructed complex fringe signals. The aliasing effects and artifacts caused by lateral scanning and sample movement were removed with a signal processing technique. The standard deviation of the phase shift of the system was reduced from 49 to 1.8 degrees with the signal processing method employed. Structural, Doppler and Doppler variance images of fluid flow through glass channels were quantified, and blood flow through vessels of chick chorioallantoic membrane (CAM) was demonstrated in vivo.. ©2005 Optical Society of America. Full Article , PDF Article ...
The artificial incubation of hens eggs involves four factors-temperature, humidity, air supply, and at intervals a rotation or turning of the eggs. This last factor is perhaps the most curious and unexpected of the four, yet there is no doubt that it is necessary for development as shown by good hatchability, and in the natural state it is carried out by the sitting hen. Eycleshymer (1906), Chattock (1925), and Olsen (1930) have all concluded from observations on the hens nest that the hen frequently rotates the eggs during the incubation period; Olsen considers it occurs as often as 96 times in 24 hours.. Various abnormalities have been recorded in eggs incubated without turning. Dareste (1891) stated that absence of turning causes the allantois to adhere to the yolk sac; Eycleshymer (1906) confirmed this, and added that during the first week of incubation, absence of turning may also cause the embryo to adhere to the shell membranes.. ...
This animation shows folding of the embryonic disc beginning week 3 of development. Embryonic disc (midline section) shown to the left and early placenta to the right. The embryonic disc dorsal (ectoderm) top and ventral (endoderm) bottom. Cranial end of disc to the left and caudal end of disc to the right. Note also the early cardiac region shown at the cranial end of disc and the allantois at the caudal end of disc extending into the connecting stalk. Folding of the embryonic disc ...
J:83256 Naiche LA, Papaioannou VE, Loss of Tbx4 blocks hindlimb development and affects vascularization and fusion of the allantois. Development. 2003 Jun;130(12):2681-93 ...
BioAssay record AID 52143 submitted by ChEMBL: Antiangiogenic activity in chicken embryo chorioallantoic membrane assay, at 100 ug/CAM was determined.
Preferred Name: Opioid Growth Factor Definition: An endogenous pentapeptide with potential antineoplastic and antiangiogenic activities. Opioid growth factor (OGF) binds to and activates the OGF receptor, present on some tumor cells and vascular cells, thereby inhibiting tumor cell proliferation and angiogenesis. (NCI05) NCI-GLOSS Definition: A substance that relieves pain and is being studied in the treatment of some types of cancer. Opioid growth factors bind to cells in the body, including tumor cells, which have opioid growth factor receptors on the surface. This may help stop the growth of the tumor cells. It may also prevent the growth of blood vessels that tumors need to grow. An opioid growth factor is a type of biological response modifier and a type of antiangiogenesis agent. Label: Opioid Growth Factor NCI Thesaurus Code: C48413 (Search for linked caDSR metadata) (search value sets) NCI Metathesaurus Link: C1541553 (see NCI Metathesaurus info) Synonyms & Abbreviations: (see Synonym ...
Introduction: The membrane-bound metalloproteinase aminopeptidase N (APN) is involved in several different cellular processes associated with the malignant phenotype. Furthermore APN has also been reported to have a functional role in tumor angiogenesis and there appear to be a strong correlation between the expression of APN and the invasive capacity of a numerous tumor cell types. The melphalan-derived prodrug melphalan-flufenamide (previously designated J1) can be activated by APN suggesting possible anti-angiogenic properties.. Experimental: A series of experiments were performed to evaluate the effects of melphalan-flufenamide on angiogenesis; cytotoxicity on bovine endothelial cells, the TCS Cellworks AngioKit model with human endothelial cells co-cultured with fibroblasts, the chicken embryo chorioallantoic membrane assay, and finally in vivo in mice using the Cultrex DIVAA angio-reactor assay.. Results: Melphalan-flufenamide displayed high cytotoxic activity against endothelial cells, ...
embryology - Extraembryonic Membranes - Most reptiles and all birds enclose their eggs in a shell. Within the shell, extraembryonic membranes take form. Two saclike membranes-the inner amnion and the outer chorion-are produced by the mesoderm of the embryo. From the end of the embryos digestive tract the allantois, an endodermal sac, grows between the amnion and the chorion.The amnion encloses a fluid-filled chamber within which the embryo grows. The allantois serves as a receptacle for embryonic wastes. Its…
In vivo heart rates of 5-day-old chick embryos were recorded from electrodes placed in close proximity to the heart. L-epinephrine (4X10(-10) mole), 1-norepinephrine (1X10(-9)mole) and 1-isoproterenol (1.6X10(-10)mole) in 5 microliter of isotonic sal
The long‐term survival and successful integration of implants for tissue replacement and regeneration highly depends upon the fast ingrowth of blood vessels from the surrounding tissues
In these animals the developing embryo shows small allantois. It will never come in contact with chorion. Their yolk sac was large. It comes in contact with chorin. This part will gain blood vessels. This part will come in contact with endometrium of uterus. This is only a contact, but not fusion. Through this contact the embryo will absorb nourishment from mother. This is called chorio vitelline placenta or Yolk sac placenta ...
A proper canine neonatal assistance, required to reduce the high perinatal loss rate, imply a full knowledge about the fetal-to-neonatal physiology. Because fetal fluids play an important role throughout mammals pregnancy, influencing fetal growth and development, fetal well being, and contributing to guarantee the most suitable environment for the fetus, the knowledge about fetal fluids biochemical composition is of major importance. At first, the biochemical composition of fetal fluids collected by normal developed, healthy and viable newborns, is necessary to depict the normal features, and represent the first step for the further detection of abnormalities associated to fetal/neonatal distress and useful for the early identification of newborns needing special attention, immediately after birth ...
We have analysed the function of transforming growth factor beta (TGF-beta) in yolk sac development in mice by generating somatic chimaeras in which the extraembryonic mesoderm, which gives rise to the endothelial and haematopoietic cells of the yolk sac vasculature, is derived from embryonic stem (ES) cells. The ES cells were stably transfected and express either the full-length type II binding receptor or a kinase-deficient mutant of this receptor. Examination of yolk sacs from chimaeras between E8.5 and 9.5, and analysis of marker expression in embryoid bodies from these mutant ES cell lines in prolonged suspension culture demonstrated that (1) a major function of TGF-beta in yolk sac mesoderm is to regulate production and deposition of fibronectin in the extracellular matrix that maintains yolk sac integrity, (2) TGF-beta signalling is not required for differentiation of extraembryonic mesoderm into endothelial cells but is necessary for their subsequent organisation into robust vessels, and ...
In chick chorioallantoic membrane (CAM) assays, injection of cilengitide into CAM vasculature prevented the growth of implanted U87MG glioma and DAOY medulloblastoma tumor fragments compared to the inactive peptide EMD135981. The inhibition of tumor growth was attributed to the anti-angiogenic activity of cilengitide as membrane vascularity surrounding the tumor graft was greatly decreased by cilengitide treatment as compared to the inactive control peptide [130]. In animal models, cilengitide, as a single agent effectively inhibited the growth and proliferation of orthotopically implanted malignant glioma and medulloblastoma cell lines in nude mice. Daily treatment of established xenografts with 100-200 µg cilengitide significantly delayed tumor growth and prolonged survival compared to controls. The delayed tumor growth was accompanied by increases in CD31 and tumor doubling times, elevated apoptotic index and decreases in proliferative index and tumor vessel number and density [130]. ...
4 Incidence Most common congenital malformation of the umbilical cord 5-10 in 1000 births (35-70 in 1000 twin births) Left artery tends to be absent more often than the right More common in Caucasian women ...
One of the major problems in assessing neovascularization in mammalian experimental animal models is the immunologic response of the host to stimuli from nonautologous species. Hence, crude bovine vitreous and retinal extracts may produce a complex immune reaction when tested in the rabbit. To circumvent this problem, the chicken chorioallantoic membrane (CAM) assay is most appropriate. In this study the CAM assay for angiogenesis has been modified to study antiangiogenic substances. The modified assay is described in detail and used to demonstrate for the first time the inhibition by adult bovine vitreous of neovascularization induced by extracts of adult bovine retina. In addition to vitreous, three common glycosaminoglycans (keratan sulfate, chondroitin sulfate C, and hyaluronic acid) were assayed for antiangiogenic activity. The results indicate that vitreous inhibition of retinal extract-induced neovascularization is dose dependent, while the sulfated glycosaminoglycans tested had no ...
Angiogenesis is an intrinsic component to chronic inflammatory process by promoting recruitment of inflammatory cells, producing cytokines, matrix-degrading enzymes, chemokines, and supplying nutrients (27, 32, 45). Very recently, pathological angiogenesis has been implicated in IBD including CD and UC (14). A notable feature in IBD tissues is the presence of aberrant vasculature and increased vessel density in the inflamed mucosa (58, 61). Additionally, IBD vessels showed impaired NO-dependent vasodilation, suggesting their contribution to reduced perfusion, poor wound healing, and persistent inflammation (26). Mucosal extracts from IBD patients induced migration of HIMECs in an IL-8-dependent manner and increased angiogenic responses in a cornea pocket assay and a chorioallantoic membrane assay (12). Moreover, clinical studies have shown elevated local concentrations of vascular endothelial growth factor (23) and increases in serum levels of basic fibroblast growth factor (b-FGF) and ...
action, Adramyttion, aegikranion, aeolodion, aigikranion, akroterion, Albion, allantoamnion, allantochorion, Amfion, Amfitrion, amfitrion, amnion, anion, antemion, anthemion, antybarion, Arion, arion, Asuncion, audion, avion, Awinion, barion, bastion, batalion, betabion, bierwion, bilion, brulion, bruLion, brzemion, bukranion, buleuterion, bulion, caccion, cebion, centurion, centylion, champion, Champollion, chondrion, chorion, ciemion, cohabitation, czempion, daimonion, dajmonion, decylion, dekurion, dikarion, dikasterion, dinokarion, Dion, duodecylion, edition, ektropion, embaterion, embolion, embrion, enchirydion, Endymion, enkomion, entropion, epeisodion, epejsodion, epicedion, epilenion, epilimnion, epinikion, epitafion, epitrachelion, epylion, epyllion, ergasterion, euroregion, fermion, fiction, fusion, galion, ganglion, generation, glutation, grafion, Gurion, gymnasion, gynaikeion, helion, hellertion, heterokarion, himation, hiparion, hipolimnion, hipparion, histrion, Hyperion, ...
action, Adramyttion, aegikranion, aeolodion, aigikranion, akroterion, Albion, allantoamnion, allantochorion, Amfion, Amfitrion, amfitrion, amnion, anion, antemion, anthemion, antybarion, Arion, arion, Asuncion, audion, avion, Awinion, barion, bastion, batalion, betabion, bierwion, bilion, brulion, bruLion, brzemion, bukranion, buleuterion, bulion, caccion, cebion, centurion, centylion, champion, Champollion, chondrion, chorion, ciemion, cohabitation, czempion, daimonion, dajmonion, decylion, dekurion, dikarion, dikasterion, dinokarion, Dion, duodecylion, edition, ektropion, embaterion, embolion, embrion, enchirydion, Endymion, enkomion, entropion, epeisodion, epejsodion, epicedion, epilenion, epilimnion, epinikion, epitafion, epitrachelion, epylion, epyllion, ergasterion, euroregion, fermion, fiction, fusion, galion, ganglion, generation, glutation, grafion, Gurion, gymnasion, gynaikeion, helion, hellertion, heterokarion, himation, hiparion, hipolimnion, hipparion, histrion, Hyperion, ...
ABSTRACT: 15 K is 1,2, 3-triazolyl ester of ketorolac, an old pain-killer, that blocks PAK1 by its R-form and inhibits COX-2 by its S-form. Mainly due to a robust increase in cell-permeability, 15K is over 500 times more potent than ketorolac in both anti-cancer and anti-PAK1 activities in cell culture with IC50 around 24 nM. However, 15K has no anti-AKT activity. Angiogenesis requires at least the kinase PAK1, and perhaps the kinase AKT as well, and is essential for a robust growth of solid tumors. Thus, in this study, we examined the potential antiangiogenic activity of 15K both in ovo and cell culture, prior to its in vivo (xenograft) anti-cancer activity test. The IC50 of 15K against the embryonic angiogenesis in ovo in CAM (chorioallantoic membrane) assay is around 1 nmol/egg. Surprizingly, however, 15K failed to inhibit the tube formation of HUVECs (human umbilical vein endothelial cells) in cell culture even at high as 150 μM. In an attempt to solve this mystery, we tested both in ovo as ...
How is Uteroferrin Associated Basic Protein abbreviated? UABP stands for Uteroferrin Associated Basic Protein. UABP is defined as Uteroferrin Associated Basic Protein rarely.
Hepatocellular cancer, one of the worlds most deadly tumors, is associated with chronic liver injury and cirrhosis. With the increasing occurrence of viral hepatitis, the incidence of this cancer in the United States continues to rise. Surgical resection offers the only hope for cure; but sadly, few patients are candidates for surgery due to their liver disease. Liver transplant can be an effective treatment, but due to a scarcity of organs, most patients do not qualify for this therapy either. Patients who are not candidates for these procedures have very few therapeutic options as chemotherapy and radiation have little efficacy. New therapies are desperately needed.. Opioid Growth Factor (OGF) inhibits the growth of a number of cancer lines in vitro by a receptor-mediated mechanism. In pancreatic cancer this phenomenon has been well defined not only in vitro but in animal models. Based upon these findings, a phase I trial has been conducted demonstrating that OGF can be administered safely to ...
Authors: Riordan NH, Meng X, Riordan HD.. ABSTRACT: Recruitment of new blood vessels plays a crucial role in tumor survival and growth. Several agents that act as angiogenesis inhibitors are currently being investigated as anti-tumor agents. Proteoglycan extract (PGM) was tested for anti-angiogenic, immunostimulatory, and anti-neoplastic activity. PGM is a non-toxic extract of the ubiquitous plant, Convolvulus arvensis. In the chicken egg chorioallantoic membrane assay PGM inhibited new blood vessel growth in a dose-dependent manner. Results were 18, 55, and 73% inhibition at concentrations of 50, 100, and 200 mcg, respectively. PGM significantly inhibited tumor growth in the mouse fibrosarcoma (S-180 Kun Ming 3-4 wk old mixed male/female, 10 animals per group, 250-1000 mcg daily doses for 14 days), and mouse Lewis lung carcinoma (C57, 6 wk old mixed male/female, 10 animals per group, 250-1000 mcg daily doses for 14 days) models. Inhibition (54-77% inhibition by weight compared to controls, up ...
The story of immunization for prevention of upper respiratory illnesses began during the second World War with influenza virus vaccines (1). Additions to the antigenic components and refinements in preparation and inactivation of the viruses derived from growth in the allantoic sac of the embryonated egg followed. Except for the prophylactic application of antibiotics for streptococcal pharyngitis little was added to the measures used for prevention of upper respiratory illnesses prior to isolation of the adenoviruses and development of vaccines from viruses propagated in tissue culture (2). Only types 3, 4, and 7 have been included because these adenoviruses have ...
This animation shows the early development of endoderm forming the gastrointestinal tract, yolk sac and allantois. The movie starts approximately week 3 and continues through week 4. Yellow shows the general lining of the yolk sac (bottom), continuous with the endoderm of the trilaminar embryonic disc (top) during week 3. As the trilaminar disc folds in this week, the foregut and hindgut regions become separated from the external yolk sac. The midgut region remains open to the yolk sac and will separate later. Foregut - Begins at the buccopharyngeal membrane, the foregut region in the head is now called the pharynx. At the lower end of the pharynx a ventral bud forms, that will later form the respiratory tract. Beneath this region the tube grows rapidly forming a dilation of the tube, that will later form the stomach. Beneath this region is the boundary of the foregut and ventrally lies the transverse septum. Midgut - Broadly open to the external yolk sac then with continued folding narrows to a ...
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MT Pinto joined Ipatimup as an Investigator Ciência 2008 (2009) of the Cancer Genetics Group and was mainly dedicated to the study of cancer related features using the CAM model. After setting up the lab and implementing several CAM assays, she established the "In vivo CAM assays service" at Ipatimup (2012) and founded the spin-off "Expertus, CAM assays" (2013-2015). MT Pinto graduated in Biochemistry (FCUP; 1999) and both MSc (FMUL; 2001) and PhD (FMUP; 2008) theses concerned the study of the endogenous pain control system in acute and chronic pain states and involved extensive use of animal models. MT Pinto has published 26 papers in international peer reviewed journals (Q1) with an H index of 12 (ResearcherID: J-2519-2013). She is co-author of two patents. ...
Figure 6.8 Structure of villi at various stages of development. A. During the fourth week. The extraembryonic mesoderm penetrates the stem villi in the
Myriocin is a powerful serine palmitoyl transferase inhibitor, by inhibiting of sphingosine biosynthesis. Myriocin is also known to have immunosuppressive activity. Here, we demonstrate the anti-angiogenic effect of myriocin. Myriocin decreased vascular endothelial cell growth factor (VEGF)-induced angiogenic process, that include proliferation, migration, invasion, tube formation and cell adhesion in human umbilical vein endothelial cells (HUVECs). Myriocin down-regulated VEGF-induced VEGFR2, focal adhesion kinase, AKT kinase, rho-associated coiled-coil-containing protein kinase 1 (ROCK1) and matrix metalloproteinase-2 (MMP2) expression. Myriocin greatly reduced new vessel formation in chick chorioallantoic membrane and vessel sprouting in mouse aortic ring assay. Furthermore, VEGF-induced phalloidin expression was inhibited by miyriocin in HUVECs. Our result indicated that myriocin inhibited VEGF-induced proliferation, migration, invasion, tube formation and cell adhesion in vitro by ...
TY - JOUR. T1 - Hydrogen sulphide induces angiogenesis. AU - Pyriochou, Anastasia. AU - Marazioti, Antonia. AU - Szabo, Csaba. AU - Papapetropoulos, Andreas. PY - 2009. Y1 - 2009. N2 - Hydrogen sulphide (H2S) is emerging as an important signalling molecule in the cardiovascular and neuronal systems. Although H2S is known to relax vascular smooth muscle leading to a reduction in blood pressure, the role of this gaseous mediator in other aspects of the biology of vascular cells remains largely unexplored. In order to study the effects of H2S on neovascularisation, we have utilised an aqueous formulation of H2S. Incubation of endothelial cells (EC) with H2S enhanced their angiogenic potential as it promoted cell growth, migration and capillary morphogenesis on matrigel. In line with the in vitro observations, treatment of chicken chorioallantoic membranes (CAM) with H2S increased vascular length. Morever, exposure of EC to H2S resulted in increased phosphorylation of kinases linked to angiogenic ...
Glaucium flavum (G. flavum) is a plant from the Papaveraceae family native to Algeria where it is used in local traditional medicine to treat warts. G. flavum root crude alkaloid extract inhibited breast cancer cell proliferation and induced G2/M phase cycle arrest and apoptosis without affecting normal cells, which is a highly awaited feature of potential anti-cancer agents. G. flavum significantly reduced growth and vascularization of human glioma tumors on chicken chorioallantoic membrane (CAM) in vivo. The chromatographic profile of the dichloromethane extract of G. flavum root showed the presence of different constituents including the isoquinoline alkaloid protopine, as the major compound. We report for the first time that G. flavum extract may represent a new promising agent for cancer chemotherapy.
In the viviparous lizard Trachylepis ivensi (Scincidae) of central Africa, reproducing females ovulate tiny ~1 mm eggs and supply the nutrients for development by placental means. Histological study shows that this species has evolved an extraordinary placental pattern long thought to be confined to mammals, in which fetal tissues invade the uterine lining to contact maternal blood vessels. The vestigial shell membrane disappears very early in development, allowing the egg to absorb uterine secretions. The yolk is enveloped precocially by the trilaminar yolk sac and no isolated yolk mass or yolk cleft develops. Early placentas are formed from the chorion and choriovitelline membranes during the neurula through pharyngula stages. During implantation, cells of the chorionic ectoderm penetrate between uterine epithelial cells. The penetrating tissue undergoes hypertrophy and hyperplasia, giving rise to sheets of epithelial tissue that invade beneath the uterine epithelium, stripping it away. As a ...
Paclitaxel is used as a single agent, and in combination with other drugs, as a standard of care in the treatment of squamous cell carcinoma of the head and neck (SCCHN). However, the use of paclitaxe
Hydrops allantois was diagnosed in two Haflinger mares with severe abdominal distension. Both mares were seven months pregnant. Abortion was induced with two injections of prostaglandin six hours apart followed by further manual dilation of the cervix and administration of oxytocin the next day. There were 90 and 95 litres of fluid, respectively, in the allantoic cavities which resembled extracellular fluid with regard to concentrations of urea, creatinine, sodium, potassium, calcium, magnesium, phosphate and chloride, but not total protein. Both fetuses had severe brain abnormalities which were diagnosed as cerebellar and cerebral hypoplasia associated with bilateral hydrocephalus internus and hydranencephaly and cerebellar aplasia, respectively. Both mares were pregnant by the same stallion, but a clear hereditary link was not found.. ...
Marques, PX, O Donovan, J, Williams, EJ, Gutierrez, J, Worrall, S, McElroy, M, Proctor, A, Brady, C, Sammin, D, Bassett, H, Buxton, D, Maley, S, Markey, BK and Nally, JE (2012) Detection of Toxoplasma gondii antigens reactive with antibodies from serum, amniotic, and allantoic fluids from experimentally infected pregnant ewes ...
The Antiangiogenic Compound Aeroplysinin-1 Induces Apoptosis in Endothelial Cells by Activating the Mitochondrial Pathway. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
There is a growing body of evidence on the importance of hemodynamic forces (i.e. blood flow and pressure) in regulating endothelial cell behavior and blood vessel formation. I was part of a recent discovery published in Nature Cell Biology that identified a new type of membrane protrusion-called inverse blebbing-at the apical membrane of endothelial cells. These inverse blebs drive the expansion of the lumen, which is a structure that allows blood to flow through the vessels. This process is therefore important in the formation of functional blood vessels ...
Skychemical is a chemistry synthesis service provider located in the Zhangjiang Hi-Tech park, Pudong district, Shanghai, China. We focus on provide Heterocyclic Building Blocks...
Institutions: 1) Germline Development Group, Center for Animal Transgenesis and Germ Cell Research, The School of Veterinary Medicine, University of Pennsylvania, New Bolton Center, 2)Centre de Neurochimie, 3)Center for Research on Reproduction and Womens Health and 4)Female Germ Cell Biology Group. In the early mammalian embryo, the germline and soma are indistinguishable from each other. In the mouse, germ cell competence is induced at embryonic day 6.5 in proximal epiblast cells by signals emanating from the extra-embryonic ectoderm. Even during the specification period, precursor cells give rise to primordial germ cells and certain somatic cells, such as extra-embryonic mesoderm and allantois. The potential of embryonic stem (ES) cells to generate all lineages of the embryo in vivo has been widely reported in the literature, in striking contrast to the lack of data describing the derivation of germ cells from ES cells in vitro. We attributed the inability to demonstrate the derivation of ...
Reptiles generally reproduce sexually, though some are capable of asexual reproduction. All reproductive activity occurs through the cloaca, the single exit/entrance at the base of the tail where waste is also eliminated. Most reptiles have copulatory organs, which are usually retracted or inverted and stored inside the body. In turtles and crocodilians, the male has a single median penis, while squamates, including snakes and lizards, possess a pair of hemipenes, only one of which is typically used in each session. Tuatara, however, lack copulatory organs, and so the male and female simply press their cloacas together as the male discharges sperm.[106]. Most reptiles lay amniotic eggs covered with leathery or calcareous shells. An amnion, chorion, and allantois are present during embryonic life. The eggshell (1) protects the crocodile embryo (11) and keeps it from drying out, but it is flexible to allow gas exchange. The chorion (6) aids in gas exchange between the inside and outside of the ...
Citation: KIM, J.G., VALLET, J.L., NONNEMAN, D.J., ROHRER, G.A., CHRISTENSON, R.K. MOLECULAR CHARACTERIZATION AND ENDOMETRIAL EXPRESSION OF PORCINE SMAD1. JOURNAL OF ANIMAL SCIENCE SUPPLEMENT. 2003. v. 81(Suppl. 1). p. 243. Abstract No. T27. Interpretive Summary: Technical Abstract: Uterine capacity contributes to litter size in swine. Previous gene mapping analyses revealed a quantitative trait locus (QTL) for uterine capacity on chromosome 8. Comparison of porcine and human genetic maps suggests that the Smad1 gene is located near this region. Smad1 mediates signal transduction from TGF-beta family ligands, including TGF-beta and bone morphogenetic proteins. In addition, Smad1 mutation in mice causes defects in allantois formation. To further explore Smad1 as a candidate gene for the uterine capacity QTL, we 1) cloned and sequenced the full coding region for Smad1, 2) examined endometrial expression of Smad1 during the estrous cycle and early pregnancy, and 3) mapped the Smad1 gene. By ...
The urinary bladder is the organ that collects urine excreted by the kidneys before disposal by urination. The urinary bladder is a triangular, hollow and distensible (or elastic) organ that is located in the lower abdominal region. Urine enters the bladder via the ureters and exits via the urethra. Bladders occur throughout much of the animal kingdom, but they are very diverse in form and in some cases are not homologous with the urinary bladder in humans. The human urinary bladder is derived in embryo from the urogenital sinus and, it is initially continuous with the allantois. In males, the base of the bladder lies between the rectum and the pubic symphysis. It is superior to the prostate, and separated from the rectum by the rectovesical excavation. In females, the bladder sits inferior to the uterus and anterior to the vagina; thus, its maximum capacity is lower than in males. It is separated from the uterus by the vesicouterine excavation. In infants and young children, the urinary bladder ...
The urinary bladder is the organ that collects urine excreted by the kidneys before disposal by urination. The urinary bladder is a triangular, hollow and distensible (or elastic) organ that is located in the lower abdominal region. Urine enters the bladder via the ureters and exits via the urethra. Bladders occur throughout much of the animal kingdom, but they are very diverse in form and in some cases are not homologous with the urinary bladder in humans. The human urinary bladder is derived in embryo from the urogenital sinus and, it is initially continuous with the allantois. In males, the base of the bladder lies between the rectum and the pubic symphysis. It is superior to the prostate, and separated from the rectum by the rectovesical excavation. In females, the bladder sits inferior to the uterus and anterior to the vagina; thus, its maximum capacity is lower than in males. It is separated from the uterus by the vesicouterine excavation. In infants and young children, the urinary bladder ...
Anticancer Effect of COX-2 Inhibitor DuP-697 Alone and in Combination with Tyrosine Kinase Inhibitor (E7080) on Colon Cancer Cell Lines Colon cancer;DuP-697;COX-2 inhibition;tyrosine kinase inhibitor; Colorectal cancer remains one of the most common types of cancer and a leading cause of cancer death worldwide. In this study, we aimed to investigate effects of DuP-697, an irreversible selective inhibitor of COX-2 on colorectal cancer cells alone and in combination with a promising new multi-targeted kinase inhibitor E7080. The HT29 colorectal cancer cell line was used. Real time cell analysis (xCELLigence system) was conducted to determine effects on colorectal cell proliferation, angiogenesis was assessed with a chorioallantoic membrane model and apoptosis was determined with annexin V staining. We found that DuP-697 alone exerted antiproliferative, antiangiogenic and apoptotic effects on HT29 colorectal cancer cells. For the antiproliferative effect the half maximum inhibition concentration ($IC_{50
INTRODUCTION. The urinary bladder in humans develops from the anterior part of the endodermal cloaca that is situated at the terminal part of the gut tube [1]. The cloaca is cleaved into anterior and posterior segments by the urorectal septum. This septum develops in a coronal plane and extends caudally to divide the cloaca into an anterior bladder and posterior rectum. The apical part of the primitive bladder is connected to the umbilicus with the allantoenteric diverticulum or the urachus. The urachus represents the remnant of either the cloaca or the allantois [2]. This communication gradually obliterates by the fourth or fifth month of intrauterine life. It remains as a fibrous cord throughout life, representing the median obliterated ligament. Adults may contain a small, blind lumen within the urachus that is lined by transitional epithelium.. Urachal anomalies are well documented and may present in adulthood with a male preponderance [3,4,5]. Autopsy studies have reported a 1 in 5000 ...
Poster (2011, January 31). DNA methylation and histone deacetylation are two key epigenetic modifications that play central role in regulation of gene expression. Several studies have shown that histone deacetylases (HDAC) and DNA ... [more ▼]. DNA methylation and histone deacetylation are two key epigenetic modifications that play central role in regulation of gene expression. Several studies have shown that histone deacetylases (HDAC) and DNA methyltransferases (DNMT) inhibitors are potent anti-angiogenic compounds. Though combination of HDAC and DNMT inhibitors are now being examined in clinical trials of hematological malignancies, little work has been done to understand the effect of this combination on physiological and tumoral angiogenesis. We have designed and tested a family of twin drugs with intrinsic HDAC and DNMT inhibitory activities in relevant models of angiogenesis in vitro (Human Umbilical Vein Endothelial Cells - HUVEC and aortic ring) and in vivo (chick chorioallantoic ...
Poster (2011, January 31). DNA methylation and histone deacetylation are two key epigenetic modifications that play central role in regulation of gene expression. Several studies have shown that histone deacetylases (HDAC) and DNA ... [more ▼]. DNA methylation and histone deacetylation are two key epigenetic modifications that play central role in regulation of gene expression. Several studies have shown that histone deacetylases (HDAC) and DNA methyltransferases (DNMT) inhibitors are potent anti-angiogenic compounds. Though combination of HDAC and DNMT inhibitors are now being examined in clinical trials of hematological malignancies, little work has been done to understand the effect of this combination on physiological and tumoral angiogenesis. We have designed and tested a family of twin drugs with intrinsic HDAC and DNMT inhibitory activities in relevant models of angiogenesis in vitro (Human Umbilical Vein Endothelial Cells - HUVEC and aortic ring) and in vivo (chick chorioallantoic ...
pock definition: A pustule brought on by smallpox or a similar eruptive disease.; A mark or scar remaining within the epidermis by such a pustule; a pockmark.; To mark with pocks; pit.; A pus filled inflammation…
Transfer of foetal fluids- rubbing an orphan lamb in the foetal fluids of the new born lamb before the ewe licks her own lamb is the most successful fostering method. An idea drawn upon this theory is to place both the new born lamb and the foster lamb into a bag or small area in order for their odours and fluids to mix and increases chance of camouflaging the foster lamb. However, this may present problems in feeding intakes and also the ewe may choose to reject both ...
by Greg Mayer One of the points I stress to students in my evolution class is that development is epigenetic: organisms develop from a less differentiated state to a more differentiated state. In modern terms, genes, the intraembryonic environment, and the extraembryonic environment interact to produce the organism through a sequence of stages going from […]. ...
Exposure of the fetus to a sub-optimal in utero environment such as poor maternal nutrition, stress or hypoxia can alter its development, potentially in a sexually dimorphic manner [1]. Male fetuses are often reported to be at greater risk of preterm birth, neonatal complications and prenatal mortality [2, 3]. For this reason, it is commonly viewed that males are more susceptible to developmental perturbations than females [4]. Critical to normal growth and viability of the fetus is adequate development of the mature chorioallantoic placenta. Males often exhibit larger placental growth (weight) than females in uncomplicated human pregnancies at term [5]. This is thought to help facilitate the greater growth trajectory of the male fetus. Sexual dimorphism in placental development is most often examined following prenatal stressors [6, 7], but inherent differences have rarely been investigated. Study of the placenta is normally restricted to analysis at late gestation or term. Interestingly, ...
Need an overview of the following topics: - Extraembryonic membranes and placentation - Digestive system - Development of nervous.
An application of 2,5-dihydroxymethyl-3,6-dimethyl pyrazine and its derivatives in the preparation of drugs for the treatment of, prevention of, and/or protection from heart failure wherein the struc
TMB Blotting PLUS™ for colorimetric detection in membrane assays based on Horseradish Peroxidase conjugates. Reactions develop a stable, dark blue color.

Allantois - WikipediaAllantois - Wikipedia

The allantois (/əˈlæntɔɪs/; plural allantoides or allantoises) is a hollow sac-like structure filled with clear fluid that ... Also, most marsupial allantoises do not fuse with the chorion. An exception is the allantois of the bandicoot, which has a ... "Allantois". dictionary.com. Downs, K.M. 1998. "The Murine Allantois". Current Topics in Developmental Biology vol. 39, pp 1-33 ... Oxygen is absorbed by the allantois through the egg shell. In most marsupials, the allantois is avascular, having no blood ...
more infohttps://en.wikipedia.org/wiki/Allantois

allantois - definition and meaningallantois - definition and meaning

allantois: A membranous sac that develops from the posterior part of the digestive tract in the embryos of mammals, birds, and ... reesetee commented on the word allantois No, I didnt--or if I did, Ive forgotten. But I think I have just the list for it ... chained_bear commented on the word allantois Reesetee, did you know this name? I didnt. (I thought it was just membrane or ... Covering the external face of the amnion and lining the inner face of the chorion is a double membrane, _the allantois_. ...
more infohttps://www.wordnik.com/words/allantois

Allantois adenomatous dysplasia | definition of allantois adenomatous dysplasia by Medical dictionaryAllantois adenomatous dysplasia | definition of allantois adenomatous dysplasia by Medical dictionary

What is allantois adenomatous dysplasia? Meaning of allantois adenomatous dysplasia medical term. What does allantois ... Looking for online definition of allantois adenomatous dysplasia in the Medical Dictionary? allantois adenomatous dysplasia ... allantois. (redirected from allantois adenomatous dysplasia). Also found in: Dictionary, Thesaurus, Encyclopedia. allantois. [ ... allantois. (ə-lăn′tō-ĭs). n. pl. allantoides (ăl′ən-tō′ĭ-dēz′) A membranous sac that develops from the posterior part of the ...
more infohttps://medical-dictionary.thefreedictionary.com/allantois+adenomatous+dysplasia

Allantois | Article about allantois by The Free DictionaryAllantois | Article about allantois by The Free Dictionary

Find out information about allantois. A fluid-filled sac- or sausagelike, extraembryonic membrane lying between the outer ... chorion and the inner amnion and yolk sac of the embryos of reptiles,... Explanation of allantois ... allantois. Also found in: Dictionary, Thesaurus, Medical, Wikipedia.. Related to allantois: yolk sac, urachus, Vitelline duct ... In the latter two groups the allantois assists in the absorption of albumin. In some mammals, including humans, the allantois ...
more infohttp://encyclopedia2.thefreedictionary.com/allantois

Notes on Yolk-sac, Amnion and Chorion and AllantoisNotes on Yolk-sac, Amnion and Chorion and Allantois

... !. 1. Yolk-sac:. It is the first structure to appear during the development ... 3. Allantois:. After 60 hours of incubation, a cloacal diverticulum of endoderm grows out from the hind gut of the embryo just ... The allantois grows rapidly and within ten days completely surrounds the embryo and yolk sac and fills the extra-embryonic ... The allantois is highly vascular and serves for respiratory exchanges. The oxygen diffusing inwards through the porous shell ...
more infohttp://www.yourarticlelibrary.com/notes/notes-on-yolk-sac-amnion-and-chorion-and-allantois/23139

BIOETYMOLOGY : ORIGIN IN BIOMEDICAL TERMS: allantoisBIOETYMOLOGY : ORIGIN IN BIOMEDICAL TERMS: allantois

Term: allantois. Origin: Anc Greek αλλάs/allas(=saugage), genitive άλλαντος/allantos because allantois resembles to sausage.. , ...
more infohttp://bioetymology.blogspot.com/2011/04/allantois.html

Allantoides | Article about allantoides by The Free DictionaryAllantoides | Article about allantoides by The Free Dictionary

Find out information about allantoides. A fluid-filled sac- or sausagelike, extraembryonic membrane lying between the outer ... chorion and the inner amnion and yolk sac of the embryos of reptiles,... Explanation of allantoides ... allantois. (redirected from allantoides). Also found in: Dictionary, Thesaurus, Medical. Allantois. A fluid-filled sac- or ... In the latter two groups the allantois assists in the absorption of albumin. In some mammals, including humans, the allantois ...
more infohttps://encyclopedia2.thefreedictionary.com/allantoides

Prenatal development | physiology | Britannica.comPrenatal development | physiology | Britannica.com

Allantois. The allantois, a tube of endoderm (the innermost germ layer), grows out of the early yolk sac in a region that soon ... As the ventral body wall closes in, the yolk stalk and allantois are brought together, along with their mesodermal sheaths and ...
more infohttps://www.britannica.com/science/prenatal-development

Epiblast-specific Snai1 deletion results in embryonic lethality due to multiple vascular defects | BMC Research Notes | Full...Epiblast-specific Snai1 deletion results in embryonic lethality due to multiple vascular defects | BMC Research Notes | Full...

Similar vascular defects were observed in the mutant allantois explants. These studies demonstrate that lethality in the Snai1- ... we analyzed vascular remodeling in cultured allantois explants from the mutant embryos. ... Allantois culture. The allantois was dissected from E8.5 mouse embryos using tungsten needles, and was placed individually on ... c, d) PECAM-1 immunostained allantois explants derived from E8.5 control (c) and Snai1-cko (d) allantoises, grown on collagen. ...
more infohttps://bmcresnotes.biomedcentral.com/articles/10.1186/1756-0500-2-22

embryology and histology Flashcards - Part 1 Boards Spinal | Brainscapeembryology and histology Flashcards - Part 1 Boards Spinal | Brainscape

branchial arches, PNS, schwann cells pia arachnoid meninges, sacral parasymps, spinal and autonomic ganglia, mesencephalic nucleus of V, melanocytes, bones CT of head, DRG, CN V, VII, IX, X ganglia, adrenal gland medulla ...
more infohttps://www.brainscape.com/flashcards/embryology-and-histology-3489266/packs/5391635

Inhibition of trophoblast stem cell potential in chorionic ectoderm coincides with occlusion of the ectoplacental cavity in the...Inhibition of trophoblast stem cell potential in chorionic ectoderm coincides with occlusion of the ectoplacental cavity in the...

Preparation of allantoises. Whole 4 somite pair (s.p.) and 8 s.p. allantoises were removed intact as described earlier (Downs ... In series 3, whole 4 s.p. and 8 s.p. allantoises as well as 4 s.p. allantois distal tips were isolated from conceptuses ... 5). Altogether, four cultures were established from whole 4 s.p. allantoises, six cultures from whole 8 s.p. allantoises and ... In series 1, allantoises that had not yet made physical contact with the ChE were removed from conceptuses by aspiration at the ...
more infohttp://dev.biologists.org/content/129/16/3913

The Cdx4 mutation affects axial development and reveals an essential role of Cdx genes in the ontogenesis of the placental...The Cdx4 mutation affects axial development and reveals an essential role of Cdx genes in the ontogenesis of the placental...

E7.5 and E8.25 allantoises were dissected from 0- to 3- and 5- to 7-somite embryos, respectively. The isolated allantois was ... The allantois appears to end as a massive ball of cells (arrow). (D) Histological analysis of the allantois shown in C. Several ... 0 mutant allantois (E). The allantois of the wild type was slightly smaller than that of the compound mutant, explaining the ... The allantoises in Cdx2+/-, Cdx2+/-/Cdx4+/- and Cdx2+/-/Cdx4-/0 mutants reach a normal size. But these three genotypes exhibit ...
more infohttp://dev.biologists.org/content/133/3/419

Transcriptional pathways in second heart field development.  - PubMed - NCBITranscriptional pathways in second heart field development. - PubMed - NCBI

al, allantois; LA, left atrium; RA, right atrium.. Transcriptional pathways in second heart field development ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/17276708?dopt=Abstract

Chorion | embryology | Britannica.comChorion | embryology | Britannica.com

accomplished by two membranes (allantois, chorion) applied closely to the shell. The allantois also receives some wastes. ... In reptiles and birds it fuses with the allantois. In direct contact with the eggshell of reptiles and birds, this ...
more infohttps://www.britannica.com/science/chorion

Early detection and staging of spontaneous embryo resorption by ultrasound biomicroscopy in murine pregnancy.  - PubMed - NCBIEarly detection and staging of spontaneous embryo resorption by ultrasound biomicroscopy in murine pregnancy. - PubMed - NCBI

E) Day 8. Embryo with amnion and allantois. (F) Day 9. The hyperechogenic decidua capsularis is stretched out at the ... Al - Allantois; Am - Amnion; DC - Decidua capsularis; EC - Embryonic cavity; Em - Embryo; GT - Giant trophoblasts; MH - ... Embryonic erythrocytes are absent in the allantois but maternal lyomphocytes, neutrophils and erythrocytes are present. (H) ... AA - Aortic arches; Al - Allantois; Am - Amnion; DB - Decidua basalis; DC - Decidua capsularis; Dec - Decidua; EC - Embryonic ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/24886361?dopt=Abstract

Anatomy: The AbdomenAnatomy: The Abdomen

Allantois: Posterior part of the yolk sac. It will become the Urogenital Sinus and primitive urogenital system. ...
more infohttps://www.kumc.edu/AMA-MSS/Study/abdomen.htm

Copy of AP Bio- Regulation 2:  Development by Amy Fansler on PreziCopy of AP Bio- Regulation 2: Development by Amy Fansler on Prezi

Allantois. : Waste Storage. Yolk. : Food Source. Fertilization events in sea urchins. Sperm releases enzymes from acrosome at ...
more infohttps://prezi.com/thzvuxzcma0g/copy-of-ap-bio-regulation-2-development/?utm_campaign=share&utm_medium=copy

Extraembryonic MembranesExtraembryonic Membranes

6. Why can the allantois be considered an adaptation to terrestrial life?. The allantois is an adaptation to dry land because ... The chorion is the membrane that covers the amnion, the yolk sac and the allantois. The space delimited by the chorion and the ... Allantois. 5. Which extraembryonic membrane has the function of storing the nitrogen wastes of the embryo? Is this function ... In reptiles and birds, in addition to the yolk sac, the amnion, the chorion and the allantois are also present. In placental ...
more infohttps://www.biology-questions-and-answers.com/extraembryonic-membranes.html

Genesis of Species/III - Wikisource, the free online libraryGenesis of Species/III - Wikisource, the free online library

the allantois. Upper Figure-Antechinus minutissimus (implacental). Lower Figure-Mus delicatulus (placental). ...
more infohttps://en.wikisource.org/wiki/Genesis_of_Species/III

Animal Development by Christopher Himmelheber on PreziAnimal Development by Christopher Himmelheber on Prezi

Allantois: Waste Storage. Yolk: Food Source Fertilization events in sea urchins Sperm releases enzymes from acrosome at tip to ...
more infohttps://prezi.com/pu4vrql2ajaj/animal-development/
  • The function of the allantois is to collect liquid waste from the embryo, as well as to exchange gases used by the embryo. (wikipedia.org)
  • The allantois is vestigial and may regress, yet the homologous blood vessels persist as the umbilical arteries and veins connecting the embryo with the placenta. (wikipedia.org)
  • The mouse allantois consists of mesodermal tissue, which undergoes vasculogenesis to form the mature umbilical artery and vein. (wikipedia.org)
  • In most marsupials, the allantois is avascular, having no blood vessels, but still serves the purpose of storing nitrogenous (NH3) waste. (wikipedia.org)
  • During the third week of development, the allantois protrudes into the area of the urogenital sinus. (wikipedia.org)
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