Hydrocarbons with at least one triple bond in the linear portion, of the general formula Cn-H2n-2.
Changing an open-chain hydrocarbon to a closed ring. (McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
Rhodium. A hard and rare metal of the platinum group, atomic number 45, atomic weight 102.905, symbol Rh. (Dorland, 28th ed)
Organic chemistry methodology that mimics the modular nature of various biosynthetic processes. It uses highly reliable and selective reactions designed to "click" i.e., rapidly join small modular units together in high yield, without offensive byproducts. In combination with COMBINATORIAL CHEMISTRY TECHNIQUES, it is used for the synthesis of new compounds and combinatorial libraries.
Unsaturated hydrocarbons of the type Cn-H2n, indicated by the suffix -ene. (Grant & Hackh's Chemical Dictionary, 5th ed, p408)
The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.
The facilitation of a chemical reaction by material (catalyst) that is not consumed by the reaction.
Isomeric forms and derivatives of PROPANOL (C3H7OH).
Organic or inorganic compounds that contain the -N3 group.
A chemical element having an atomic weight of 106.4, atomic number of 46, and the symbol Pd. It is a white, ductile metal resembling platinum, and following it in abundance and importance of applications. It is used in dentistry in the form of gold, silver, and copper alloys.
Alicyclic hydrocarbons in which three or more of the carbon atoms in each molecule are united in a ring structure and each of the ring carbon atoms is joined to two hydrogen atoms or alkyl groups. The simplest members are cyclopropane (C3H6), cyclobutane (C4H8), cyclohexane (C6H12), and derivatives of these such as methylcyclohexane (C6H11CH3). (From Sax, et al., Hawley's Condensed Chemical Dictionary, 11th ed)
Acyclic branched or unbranched hydrocarbons having two carbon-carbon double bonds.
A hard, brittle, grayish-white rare earth metal with an atomic symbol Ru, atomic number 44, and atomic weight 101.07. It is used as a catalyst and hardener for PLATINUM and PALLADIUM.
Synthetic organic reactions that use reactions between unsaturated molecules to form cyclical products.
The creation of an amine. It can be produced by the addition of an amino group to an organic compound or reduction of a nitro group.
Saturated indolizines that are fused six and five-membered rings with a nitrogen atom at the ring fusion. They are biosynthesized in PLANTS by cyclization of a LYSINE coupled to ACETYL COENZYME A. Many of them are naturally occurring ALKALOIDS.
A class of compounds of the type R-M, where a C atom is joined directly to any other element except H, C, N, O, F, Cl, Br, I, or At. (Grant & Hackh's Chemical Dictionary, 5th ed)
Compounds similar to hydrocarbons in which a tetravalent silicon atom replaces the carbon atom. They are very reactive, ignite in air, and form useful derivatives.
Organic compounds that contain GOLD as an integral part of the molecule. Some are used as ANTIRHEUMATIC AGENTS. The term chrysotherapy derives from an ancient Greek term for gold.
Organic compounds that contain silicon as an integral part of the molecule.
A chemosterilant agent that is anticipated to be a carcinogen.
Organic compounds that contain the -NCO radical.
Compounds with two triple bonds. Some of them are CYTOTOXINS.
A technology, in which sets of reactions for solution or solid-phase synthesis, is used to create molecular libraries for analysis of compounds on a large scale.
Ring compounds having atoms other than carbon in their nuclei. (Grant & Hackh's Chemical Dictionary, 5th ed)
A heavy metal trace element with the atomic symbol Cu, atomic number 29, and atomic weight 63.55.

Smoothing of the thermal stability of DNA duplexes by using modified nucleosides and chaotropic agents. (1/688)

The effect of alkyltrimethylammonium ions on the thermostability of natural and modified DNA duplexes has been investigated. We have shown that the use of tetramethylammonium ions TMA+along with the chemical modification of duplexes allow the fine adjustment of T m and the possibility of obtaining several duplex systems with varied isostabilizedtemperatures, some of which show greater stability than those of natural DNA. This approach could be very useful for DNA sequencing by hybridization.  (+info)

Inhibition of glutathione synthesis with propargylglycine enhances N-acetylmethionine protection and methylation in bromobenzene-treated Syrian hamsters. (2/688)

The finding that liver necrosis caused by the environmental glutathione (GSH)-depleting chemical, bromobenzene (BB) is associated with marked impairment in O- and S-methylation of BB metabolites in Syrian hamsters raises questions concerning the role of methyl deficiency in BB toxicity. N-Acetylmethionine (NAM) has proven to be an effective antidote against BB toxicity when given after liver GSH has been depleted extensively. The mechanism of protection by NAM may occur via a replacement of methyl donor and/or via an increase of GSH synthesis. If replacement of the methyl donor is an important process, then blocking the resynthesis of GSH in the methyl-repleted hamsters should not decrease NAM protection. This hypothesis was examined in this study. Propargylglycine (PPG), an irreversible inhibitor of cystathionase, was used to inhibit the utilization of NAM for GSH resynthesis. Two groups of hamsters were pretreated with an intraperitoneal (ip) dose of PPG (30 mg/kg) or saline 24 h before BB administration (800 mg/kg, ip). At 5 h after BB treatment, an ip dose of NAM (1200 mg/kg) was given. Light microscopic examinations of liver sections obtained 24 h after BB treatment indicated that NAM provided better protection (P < 0.05) in the PPG + BB + NAM group than in the BB + NAM group. Liver GSH content, however, was lower in the PPG + BB + NAM group than in the BB + NAM group. The Syrian hamster has a limited capability to N-deacetylated NAM. The substitution of NAM with methionine (Met; 450 mg/kg) resulted in a higher level of GSH in the BB + Met group than in the BB + NAM group (P < 0.05). The enhanced protection by PPG in the PPG + BB + NAM group was accompanied by higher (P < 0.05) urinary excretions of specificO- and S-methylated bromothiocatechols than in the BB + NAM group. The results suggest that NAM protection occurs primarily via a replacement of the methyl donor and that methyl deficiency occurring in response to GSH repletion plays a potential role in BB toxicity.  (+info)

Inhibition of gene expression by anti-sense C-5 propyne oligonucleotides detected by a reporter enzyme. (3/688)

Using a reporter plasmid containing the luciferase gene under the control of the insulin-like growth factor 1 (IGF-1) promoter region [including its 5' untranslated region (UTR)], we demonstrate that a 17-mer oligophosphorothioate containing C-5 propyne pyrimidines is able to inhibit luciferase gene expression in the nanomolar concentration range when the anti-sense oligonucleotide is targeted either to a coding sequence in the luciferase gene or to the 5' UTR of the gene for IGF-1. Inhibition was obtained independently of whether the plasmid and the anti-sense oligonucleotide were co-transfected or transfected separately into hepatocarcinoma cells. However, the efficiency of inhibition by the anti-sense oligonucleotides was 10-fold greater in the first case. The unmodified oligophosphorothioate targeted to the 5' UTR of IGF-1 did not inhibit luciferase gene expression at a 100-fold higher concentration unless its length was increased from 17 to 21 nt, in which case an inhibition of gene expression was obtained and an IC50 of 200 nM was observed.  (+info)

Elevated expression of liver gamma-cystathionase is required for the maintenance of lactation in rats. (4/688)

Liver gamma-cystathionase activity increases in rats during lactation; its inhibition due to propargylglycine is followed by a significant decrease in lactation. This is reversible by N-acetylcysteine administration. To study the role of liver gamma-cystathionase and the intertissue flux of glutathione during lactation, we used lactating and virgin rats fed liquid diets. Virgin rats were divided into two groups as follows: one group was fed daily a diet containing the same amount of protein that was consumed the previous day by lactating rats (high protein diet-fed rats); the other virgin group was fed the normal liquid diet (control). The expression and activity of liver gamma-cystathionase were significantly greater in lactating rats and in high protein diet-fed virgin rats compared with control rats. The total glutathione [reduced glutathione (GSH) + oxidized glutathione (GSSG)] released per gram of liver did not differ in lactating rats or in high protein diet-fed rats, but it was significantly higher in these two groups than in control virgin rats. Liver size and the GSH + GSSG released by total liver were significantly higher in lactating rats than in high protein diet-fed virgin rats, and this difference was similar to the amount of glutathione taken up by the mammary gland (454.2 +/- 36.0 nmol/min). The uptake of total glutathione by the lactating mammary gland was much higher than the uptakes of free L-cysteine and L-cystine, which were negligible. These data suggest that the intertissue flux of glutathione is an important mechanism of L-cysteine delivery to the lactating mammary gland, which lacks gamma-cystathionase activity. This emphasizes the physiologic importance of the increased expression and activity of liver gamma-cystathionase during lactation.  (+info)

Guest exchange in an encapsulation complex: a supramolecular substitution reaction. (5/688)

Encapsulation complexes are reversibly formed assemblies in which small molecule guests are completely surrounded by large molecule hosts. The assemblies are held together by weak intermolecular forces and are dynamic: they form and dissipate on time scales ranging from milliseconds to days-long enough for many interactions, even reactions, to take place within them. Little information is available on the exchange process, how guests get in and out of these complexes. Here we report that these events can be slow enough for conventional kinetic studies, and reactive intermediates can be detected. Guest exchange has much in common with familiar chemical substitution reactions, but differs in some respects: no covalent bonds are made or broken, the substrate is an assembly rather than a single molecule, and at least four molecules are involved in multiple rate-determining steps.  (+info)

Effects of a lipoxygenase inhibitor, panaxynol, on vascular contraction induced by angiotensin II. (6/688)

We investigated whether a lipoxygenase inhibitor, panaxynol, affected the vascular contraction induced by angiotensin (Ang) II and the mean arterial pressure in spontaneously hypertensive rats (SHR). Panaxynol suppressed dose-dependently the contractile responses induced by 30 nM Ang II in isolated intact and endothelial cell-denuded aorta in the hamster. IC50 values in the intact and endothelial cell-denuded aorta were 23 and 20 microM, respectively. In SHR, the mean arterial pressure after injection of 30 and 60 mg/kg panaxynol was reduced, and the maximum hypotensive values were 23 and 48 mmHg, respectively. Thus, lipoxygenase products may affect the renin-angiotensin system.  (+info)

Similarity and dissimilarity in mode and mechanism of action between YT-146, a selective adenosine receptor A2 agonist, and adenosine in isolated canine hearts. (7/688)

To elucidate the differences in mode and mechanism of action between YT-146, a highly selective adenosine A2 receptor agonist, and adenosine, we compared their effects on coronary circulation and myocardium and modifications of these effects by glibenclamide, a blocker of ATP-sensitive potassium (K) channels, in three kinds of isolated, blood-perfused canine heart preparations. YT-146 and adenosine were injected i.a. In all preparations both YT-146 and adenosine increased coronary blood flow and in this respect YT-146 was about 5 times as potent as adenosine. The increase in blood flow caused by adenosine was transient, whereas that produced by YT-146 was biphasic; the transient increase was followed by a sustained one. In isolated, blood-perfused sinoatrial (SA) node preparations, YT-146 failed to affect sinus rate, whereas adenosine reduced sinus rate by about 38% at its maximum effect. In isolated, blood-perfused atrioventricular (AV) node preparations, when injected into the artery supplying the AV node, YT-146 exerted no effect on AV conduction time, whereas adenosine prolonged AV conduction time by about 17% at the maximum effect. In isolated, blood-perfused papillary muscle preparations, the force of contraction was affected by neither YT-146 nor adenosine. In the same preparations the effect of YT-146 in increasing coronary blood flow was antagonized by glibenclamide in such a manner that the maximum increase was suppressed, but that of adenosine was not. Reactive hyperemia induced by ischemia for 30 seconds was not affected by glibenclamide. These results suggest that although both YT-146 and adenosine produce an increase in coronary blood flow via adenosine A2 receptors, the opening of ATP- or glibenclamide-sensitive K channels is involved in the action of the former, but scarcely in the action of the latter. The opening of ATP- or glibenclamide-sensitive K-channels is less likely involved in reactive hyperemia.  (+info)

NAD(+)-dependent (S)-specific secondary alcohol dehydrogenase involved in stereoinversion of 3-pentyn-2-ol catalyzed by Nocardia fusca AKU 2123. (8/688)

An NAD(+)-dependent alcohol dehydrogenase was purified to homogeneity from Nocardia fusca AKU 2123. The enzyme catalyzed (S)-specific oxidation of 3-pentyn-2-ol (PYOH), i.e., part of the stereoinversion reaction for the production of (R)-PYOH, which is a valuable chiral building block for pharmaceuticals, from the racemate. The enzyme used a broad variety of secondary alcohols including alkyl alcohols, alkenyl alcohols, acetylenic alcohols, and aromatic alcohols as substrates. The oxidation was (S)-isomer specific in every case. The K(m) and Vmax for (S)-PYOH and (S)-2-hexanol oxidation were 1.6 mM and 53 mumol/min/mg, and 0.33 mM and 130 mumol/min/mg, respectively. The enzyme also catalyzed stereoselective reduction of carbonyl compounds. (S)-2-Hexanol and ethyl (R)-4-chloro-3-hydroxybutanoate in high optical purity were produced from 2-hexanone and ethyl 4-chloro-3-oxobutanoate by the purified enzyme, respectively. The K(m) and Vmax for 2-hexanone reduction were 2.5 mM and 260 mumol/min/mg. The enzyme has a relative molecular mass of 150,000 and consists of four identical subunits. The NH2-terminal amino acid sequence of the enzyme shows similarity with those of the carbonyl reductase from Rhodococcus erythropolis and phenylacetaldehyde reductase from Corynebacterium sp.  (+info)

Youre right; the definition in your book is simplistic. A terminal alkyne would be better defined as an alkyne with the formula $\ce{RC_2H}$, differentiating from an internal alkyne, which would have the formula $\ce{RC_2R}$ and the added stipulation that neither R nor R can be a hydrogen. Equivalently stated as in Wikipedia, an internal alkyne has carbon substitutents on all acetylenic carbons, and a terminal alkyne is therefore not an internal alkyne because at least one acetylenic carbon has a hydrogen bonded to it.. The example formula you cite is vinylacetylene, systematic name butenyne or 1-buten-3-yne (heres your IUPAC nomenclature rules favoring double bonds at work; otherwise itd be ethynylbutene or similar). It is indeed an example of a terminal alkyne, having the exploded formula (C2H3)C2H.. ...
Evaluation of biofilm formation on novel copper-catalyzed azide-alkyne cycloaddition (CuAAC)-based resins for dental restoratives Journal Article ...
TY - JOUR. T1 - Hydrosilylation of alkynes catalysed by platinum on titania. AU - Alonso, Francisco. AU - Buitrago, Robison. AU - Moglie, Yanina. AU - Ruiz-Martínez, Javier. AU - Sepúlveda-Escribano, Antonio. AU - Yus, Miguel. N1 - Generated from Scopus record by KAUST IRTS on 2019-08-08. PY - 2011/1/1. Y1 - 2011/1/1. N2 - The heterogeneous hydrosilylation of alkynes catalysed by platinum on titania is reported. A variety of hydrosilanes react with both terminal and internal alkynes to furnish the corresponding vinyl silanes in high yields and short reaction times as well as in a regio- and stereoselective manner. The catalyst can be easily recovered and reused in several consecutive cycles. © 2010 Elsevier B.V. All rights reserved.. AB - The heterogeneous hydrosilylation of alkynes catalysed by platinum on titania is reported. A variety of hydrosilanes react with both terminal and internal alkynes to furnish the corresponding vinyl silanes in high yields and short reaction times as well as ...
TY - JOUR. T1 - Rhodium-catalyzed oxidative cycloaddition of benzamides and alkynes via C-H/N-H activation. AU - Hyster, Todd K.. AU - Rovis, Tomislav. PY - 2010/8/4. Y1 - 2010/8/4. N2 - The oxidative cycloaddition of benzamides and alkynes has been developed. The reaction utilizes Rh(III) catalysts in the presence of Cu(II) oxidants, and is proposed to proceed by N-H metalation of the amide followed by ortho C-H activation. The resultant rhodacycle undergoes alkyne insertion to form isoquinolones in good yield. The reaction is tolerant of extensive substitution on the amide, alkyne, and arene, including halides, silyl ethers, and unprotected aldehydes as substituents. Unsymmetrical alkynes proceed with excellent regioselectivity, and heteroaryl carboxamides are tolerated leading to intriguing scaffolds for medicinal chemistry. A series of competition experiments shed further light on the mechanism of the transformation and reasons for selectivity.. AB - The oxidative cycloaddition of benzamides ...
Rh(III)-catalyzed C−H bond annulation with alkynes has excogitated into a potent method for the preparation of highly substituted polycyclic aromatic and heteroaromatic compounds. Here Rh(III)-catalyzed annulation of 4-phenyl quinazolines with internal alkynes via dual C−H bond activation has been explored. The synthetic procedure has the advantages of high efficiency and functional group tolerance, excellent regioselectivity and broad substrate scope under mild conditions and some of the resulting products exhibit intense fluorescence in the solution state. Such structural motifs may important precursors for further transformations into biologically active compounds & π-conjugated functional materials such as organic semiconductors and luminescent materials which have broad prospect in future life.. ...
Transition-metal-mediated cross coupling reaction of alkynes and alkenes has recently gained increasing significance in organic chemistry because it represents an efficient method for the formation of new carbon-carbon bond. In recent years, two types of the coupling reactions have been developed: intramolecular couplings of enynes and intermolecular couplings of alkynes and alkenes. These results were classified into two mechanistic pathways, one not involving carbon-carbon bond cleavage, insertion mechanism, and the other involving carbon-carbon bond cleavage, metathesis mechanism. While the coupling reactions of alkynes with substituted alkenes have been well developed, there are very few reports on the coupling of alkynes with the simplest alkene, ethylene documented in the literature. Our research goal is to develop a new rutheniumbased system to study the coupling reactions of alkynes with ethylene, and extend its scope to enyne and substituted alkenes.
TY - JOUR. T1 - Well-defined (co)polypeptides bearing pendant alkyne groups. AU - Zhao, Wei. AU - Gnanou, Yves. AU - Hadjichristidis, Nikos. N1 - KAUST Repository Item: Exported on 2020-10-01 Acknowledgements: The research reported in this publication was supported by funding from King Abdullah University of Science and Technology (KAUST).. PY - 2016. Y1 - 2016. N2 - A novel metal-free strategy, using hydrogen-bonding catalytic ring opening polymerization of acetylene-functionalized N-carboxy anhydrites of α-amino acids, was developed for the synthesis of well-defined polypeptides bearing pendant alkyne groups. This method provides an efficient way to synthesize novel alkyne-functionalized homopolypeptides (A) and copolypeptides, such as AB diblock (B: non-functionalized), ABA triblock and star-AB diblock, as well as linear and star random copolypeptides, precursors of a plethora complex macromolecular architectures by click chemistry.. AB - A novel metal-free strategy, using hydrogen-bonding ...
Wang, Y.-F., Toh, K. K., Lee, J.-Y. and Chiba, S. (2011), Synthesis of Isoquinolines from α-Aryl Vinyl Azides and Internal Alkynes by Rh-Cu Bimetallic Cooperation. Angew. Chem., 123: 6049-6053. doi: 10.1002/ange.201101009 ...
Synonyms for alkyne in Free Thesaurus. Antonyms for alkyne. 2 synonyms for alkyne: acetylene, ethyne. What are synonyms for alkyne?
Communications DOI: 10.1002/anie.201100252 Asymmetric Catalysis C1-Symmetric Rh/Phebox-Catalyzed Asymmetric Alkynylation of a-Ketoesters** Takashi Ohshima,* Takahito Kawabata, Yosuke Takeuchi, Takahiro Kakinuma, Takanori Iwasaki, Takayuki Yonezawa, Hajime Murakami, Hisao Nishiyama, and Kazushi Mashima* Catalytic asymmetric alkynylation of carbonyl compounds is one of the most efficient routes for the synthesis of optically active propargylic alcohols, which are useful and versatile building blocks for a variety of functionalized molecules, such as biologically active natural products.[1] In the initial stages of development of this transformation, stoichiometric amounts of metal reagents such as organolithium, organomagnesium, and diorganozinc compounds were used to increase the nucleophilicity of the alkyne and to prevent an undesired retro reaction.[1, 2] In terms of atom economy,[3] however, the direct in situ generation of a metal alkynylide species from terminal alkynes using a catalytic ...
A regioselective hydroboration of alkynes has been developed by using commercially available zinc triflate as a catalyst, in the presence of catalytic amount of NaBHEt3. The reaction tolerates a wide range of terminal alkynes having several synthetically useful functional groups and proceeds regioselectively to furnish hydroborated products in moderate to excellent yields. This system shows moderate chemoselectivity towards terminal C equivalent to C bond over terminal and internal C=C bond and internal C equivalent to C bond.. ...
In this work, we confirmed that the copper-catalysed azide-alkyne cycloaddition (CuAAC) reaction is an effective method for the organic-functionalization of polyoxometalates (POMs). Herein, for the first time, four novel 1,2,3-triazole functionalized polyoxovanadate (POV) organic-inorganic hybrids, (Bu4N)2[V6O13{(O
TY - GEN. T1 - A new sinthetic application of (dichloroiodo)benzene in reactions with alkenes and alkynes. AU - Yusubova, R. J.. AU - Filimonov, V. D.. AU - Yusubov, M. S.. AU - Chi, Ki Whan. PY - 2004. Y1 - 2004. N2 - A convenient synthesis of vicinal methoxychlorides, methoxyiodides from alkenes and alkynes using PhICl2/CH3OH, I 2/PhICl2/CH3OH is described.. AB - A convenient synthesis of vicinal methoxychlorides, methoxyiodides from alkenes and alkynes using PhICl2/CH3OH, I 2/PhICl2/CH3OH is described.. KW - (dichloroiodo)Benzene. KW - Alkenes. KW - Alkynes. KW - Chloromethoxylation. KW - Iodomethoxylation. UR - http://www.scopus.com/inward/record.url?scp=29144459782&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=29144459782&partnerID=8YFLogxK. M3 - Conference contribution. AN - SCOPUS:29144459782. SN - 0780383834. SN - 9780780383838. VL - 2. SP - 97. EP - 98. BT - 8th Korea-Russia International Symposium on Science and Technology - Proceedings: KORUS 2004. ER - ...
TY - JOUR. T1 - New oxidative transformations of alkenes and alkynes under the action of diacetoxyiodobenzene. AU - Yusubov, M. S.. AU - Zholobova, G. A.. AU - Filimonova, I. L.. AU - Chi, Ki Whan. PY - 2004/8/1. Y1 - 2004/8/1. N2 - Treatment of alkenes and alkynes with diacetoxyiodobenzene activated by mineral and organic acids predominantly results in oxidative rearrangement. 1,4-Diphenylbutadiene in MeOH gives 3,4-dimethoxy-1,4-diphenylbut-1-ene.. AB - Treatment of alkenes and alkynes with diacetoxyiodobenzene activated by mineral and organic acids predominantly results in oxidative rearrangement. 1,4-Diphenylbutadiene in MeOH gives 3,4-dimethoxy-1,4-diphenylbut-1-ene.. KW - Alkenes. KW - Alkynes. KW - Diacetoxyiodobenzene. KW - Oxidative rearrangement. KW - Polyvalent iodine compounds. UR - http://www.scopus.com/inward/record.url?scp=14944340734&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=14944340734&partnerID=8YFLogxK. U2 - 10.1007/s11172-005-0027-8. DO - ...
Best Chemical Properties Of The Alkynes Online Homework Help, Assignment Help providers on internet. 24 X 7 live online tutoring at Assignmenthelp.net.
TY - JOUR. T1 - Synthesis of Strained 1,3-Diene Macrocycles via Copper-Mediated Castro-Stephens Coupling/Alkyne Reduction Tandem Reactions. AU - Li, Wei. AU - Schneider, Christopher M.. AU - Georg, Gunda I.. PY - 2015/8/7. Y1 - 2015/8/7. N2 - A copper-mediated macrocyclization involving the reaction of a vinyl iodide and a terminal alkyne followed by an in situ reduction of the enyne intermediate is reported. The reaction generates a conjugated Z-double bond within a strained medium-size lactone, lactam, or ether macrocycle. A variety of macrocyclic compounds bearing different ring sizes and functionalities were synthesized. A complementary stepwise procedure was also developed for less strained ring systems.. AB - A copper-mediated macrocyclization involving the reaction of a vinyl iodide and a terminal alkyne followed by an in situ reduction of the enyne intermediate is reported. The reaction generates a conjugated Z-double bond within a strained medium-size lactone, lactam, or ether ...
Highly enantioselective allylic alkynylation of racemic bromides under biphasic condition is furnished in this report. This approach employs functionalized terminal alkynes as pro-nucleophiles and provides 6- and 7-membered cyclic 1,4-enynes with high yields and excellent enantioselectivities (up to 96% ee) under mild conditions. Enantioretentive derivatizations highlight the synthetic utility of this transformation. Cold-spray ionization mass spectrometry (CSI-MS) and X-ray crystallography were used to identify some catalytic intermediates, which include guanidinium cuprate ion pairs and a copper-alkynide complex. A linear correlation between the enantiopurity of the catalyst and reaction product indicates the presence of a copper complex bearing a single guanidine ligand at the enantio-determining step. Further experimental and computational studies supported that the alkynylation of allylic bromide underwent an anti-SN2 pathway catalyzed by nucleophilic cuprate species. Moreover, ...
TY - JOUR. T1 - Bismuth(III)-Catalyzed hydration of terminal alkynes. T2 - Sustainable synthesis of methyl ketones in batch and flow. AU - Ötvös, Sándor B.. AU - Szécsényi, Zsanett. AU - Fülöp, F.. PY - 2019/8/5. Y1 - 2019/8/5. N2 - Environmentally benign synthesis of methyl ketones is demonstrated via unprecedented bismuth(III)-catalyzed activation and Markovnikov-type hydration of terminal acetylenes. Besides a batch process operating under reasonably mild conditions, a chemically intensified high-temperature continuous-flow methodology has also been developed using a coil reactor. The preparative capabilities of the flow process were demonstrated with multigram-scale alkyne hydrations. The methods presented rely on readily available bismuth(III) salts as green catalysts and exhibit less environmental concerns than earlier methods.. AB - Environmentally benign synthesis of methyl ketones is demonstrated via unprecedented bismuth(III)-catalyzed activation and Markovnikov-type hydration ...
Acetylene is the ultimate carbon building block (on paper, anyway!). It bears two relatively acidic C-H bonds (pKa 25) and can therefore be alkylated (i.e. deprotonated to give its conjugate base, then treated with an alkyl halide) on either end giving either a mono-substituted (also known as a terminal alkyne) or di-substituted (internal) alkyne as desired. This is important because in first semester organic chemistry, this reaction represents an important means of extending the carbon chain. You dont learn that many reactions that form C-C. This reaction comes up a lot ...
Outline1. Bonding in alkynes. sp-Hybridization2. Physical properties and nomenclature of alkynes 3. Preparation and use of alkynes4. Addition to triple bonds. Hydrohalogenation5. Addition to triple bonds. Hydration6. Addition to triple bonds. Hydroboration-oxidation7. Addition to triple bonds....
Alkynes Hydrocarbons that contain carbon-carbon triple bonds C≡C Acetylene, the simplest alkyne is produced industrially from methane and steam at high temperature Our study of alkynes provides an introduction to organic synthesis, the preparation of organic molecules from simpler organic molecules
TY - JOUR. T1 - Hydrofluoroarylation of alkynes with fluoroarenes. AU - Kanyiva, Stephen Kyalo. AU - Kashihara, Natsuko. AU - Nakao, Yoshiaki. AU - Hiyama, Tamejiro. AU - Ohashi, Masato. AU - Ogoshi, Sensuke. PY - 2010/11/21. Y1 - 2010/11/21. N2 - A combination of Ni(cod)2 and PCyp3 is found to be an effective catalyst for chemoselective activation of the C-H bond of fluoroarenes over C-F bonds followed by insertion of alkynes to allow direct alkenylation of the electron-deficient arenes. The characteristics of the reactions are: a C-H bond ortho to a fluorine substituent is selectively activated; the reactivity of fluorobenzenes is roughly proportional to the number of fluorine atoms. The reaction conditions tolerate a broad range of both alkynes and fluoroarenes containing both electron-withdrawing and -donating groups, thus allowing efficient synthesis of a variety of substituted ethenes containing a fluoroaryl motif in high regio- and stereoselective manners. Mechanistic studies including ...
TY - JOUR. T1 - A strategy for conditional orthogonal sequential CuAAC reactions using a protected aromatic ynamine. AU - Hatit, Marine Z. C.. AU - Seath, Ciaran P.. AU - Watson, Allan J. B.. AU - Burley, Glenn A.. N1 - This document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal of Organic Chemistry, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.joc.7b00545.. PY - 2017/4/28. Y1 - 2017/4/28. N2 - A method for conditional control of orthogonal sequential Cu-catalyzed azide alkyne cycloaddition (CuAAC) reactions is reported. The inherent reactivity of an aromatic ynamine is controlled by a silyl protecting group that allows the selective CuAAC reaction of less reactive alkynes. Alternatively, the same protected ynamine undergoes selective CuAAC reaction via silyl deprotection in situ to give theynamine click products. This ...
This has some implications in the properties and chemical reactivity of sigma and pi bonds. Ethyne or acetylene, HC=CH, is the simplest alkyne example. The process for understanding the sp hybridization process for carbon is basically an extension of the other two types (sp 3 and sp 2). Thus, in acetylene (ethyne), there are two unhybridized orbitals, which, by convention are and (see figure below): Figure: Illustrating the sp orbitals. The triple bonded carbon atoms of acetylene aresp hybridized. The sigma bond is short and strong. E)An alkyne reacts as an electrophile,and is therefore electron poor. Type of â ¦ You should try to work out this scheme on your own and see if your predictions agree with those presented in the textbook. is related to Unsaturated Hydrocarbons Quiz. The Structure of Ethyne (Acetylene): sp Hybridization ** Hydrocarbons in which two carbon atoms share three pairs of electrons between them, and are thus bonded by a triple bond, are called alkynes. Correspondingly, ...
Herein we report unprecedented manganese-catalyzed semihydrogenation of internal alkynes to (Z)-alkenes using ammonia borane as a hydrogen donor. The reaction is catalyzed by a pincer complex of the earth-abundant manganese(II) salt in the absence of any additives, base, or superhydride. The ammonia borane smoothly reduces the manganese precatalyst [Mn(II)-PNP][Cl]2 to the catalytically active species [Mn(I)-PNP]-hydride in the triplet spin state. This manganese hydride is highly stabilized by complexation with the alkyne substrate. Computational density functional theory (DFT) analysis studies of the reaction mechanism rationalize the origin of stereoselectivity toward formation of (Z)-alkenes ...
Alkyne functionalized Single layer graphene Flake size: 0.5-5 microns. Thickness: Single atomic layer >80% Purity: Carbon contents over 80% Alkyne functionalized online from Mknano.com.
Alkynes and Their Reactions Naming Alkynes Alkynes are named in the same general way that alkenes are named. In the IUPAC system, change the ane ending of the parent alkane name to the suffix yne. Choose
ALKYnes sem 1: 2011/2012. Khadijah Hanim bt Abdul Rahman School of Bioprocess Engineering, UniMAP Week 5: 13/10/2011 [email protected] Learning outcomes. Structure, nomenclature and naming alkynes DEFINE and ILLUSTRATE the principle in naming alkynes on few examples...
A Lewis acid-catalyzed insertion of unsymmetrical alkynes into electron-deficient alkenes was developed for the first time, and used to produce 34 hitherto unreported pentacyclic benzo[5,6]chromeno[2,3-b]indoles with generally good yields and complete stereoselectivity. A Yb(OTf)3-catalyzed reaction between
Preparation, properties and reactions of alkenes and alkynes: Physical properties of alkenes and alkynes (boiling points, density and dipole moments); Acidity of alkynes; Acid catalysed hydration of alkenes and alkynes (excluding the stereochemistry of addition and elimination); Reactions of alkenes with KMnO4 and ozone; Reduction of alkenes and alkynes; Preparation of alkenes and alkynes by elimination reactions; Electrophilic addition reactions of alkenes with X2, HX, HOX and H2O (X=halogen); Addition reactions of alkynes; Metal acetylides ...
Rhodium-Catalyzed Intermolecular Alkyne Cyclotrimerization Route to a Functionalized CycloparaphenyleneRhodium-Catalyzed Intermolecular Alkyne Cyclotrimerization Route to a Functionalized Cycloparaphenylene ...
A metal-free oxidative trifluoromethyl-thiolation of terminal alkynes using readily available CF3SiMe3 and elemental sulfur at room temperature has been developed. This reaction provides an efficient and convenient method for the preparation of alkynyl trifluoromethyl sulfides bearing a wide range of functional groups. Preliminary investigation revealed that elemental sulfur instead of air acted as the oxidant ...
TY - JOUR. T1 - Dual Inhibition of Mycobacterial Fatty Acid Biosynthesis and Degradation by 2-Alkynoic Acids. AU - Morbidoni, Hector R.. AU - Vilchèze, Catherine. AU - Kremer, Laurent. AU - Bittman, Robert. AU - Sacchettini, James C.. AU - Jacobs, William R.. N1 - Funding Information: H.R.M. is a Career Investigator of Consejo de Investigaciones de la Universidad Nacional de Rosario (CIURN), Argentina. This work was supported by National Institutes of Health grant AI43268. L.K. is supported by a grant from the Centre National de la Recherche Scientifique (Actions Thématiques et Incitatives sur Programmes Microbiologie Fondamentale).. PY - 2006/3. Y1 - 2006/3. N2 - 2-Hexadecynoic acid and 2-octadecynoic acid have cidal activity against Mycobacterium smegmatis and Mycobacterium bovis BCG. At subinhibitory concentrations, M. smegmatis rapidly transformed [1-14C]-2-hexadecynoic acid into endogenous fatty acids and elongated them into mycolic acids. Toxic concentrations of 2-hexadecynoic acid ...
TY - JOUR. T1 - Catalytic Enantioselective Addition of Terminal Alkynes to Aldehydes: Preparation of (S)-(-)-1,3-Diphenyl-2-Propyn-1-ol and (S)-(-)-4-Methyl-1-Phenyl-2-Pentyn-1,4-Diol. AU - Takita, Ryo. AU - Harada, Shinji. AU - Ohshima, Takashi. AU - Matsunaga, Shigeki. AU - Shibasaki, Masakatsu. PY - 2008. Y1 - 2008. U2 - 10.1002/0471264229.os085.13. DO - 10.1002/0471264229.os085.13. M3 - Article. VL - 85. JO - Organic Syntheses. JF - Organic Syntheses. SN - 0078-6209. ER - ...
ABSTRACT FOR PART I: HYDROPHENOXYLATION REACTIONS CATALYZED BY ARYLGOLD(I) COMPOUNDS Both carbine and phosphine ligated arylgold(I) compounds have been synthesized and investigated as single-component catalysts for the hydrophenoxylation of unactivated internal alkynes to yield vinyl ethers. Catalysts containing either JohnPhos or IPr/SIPr were found to be the most efficient catalysts during the screening process. Electron-withdrawing and electron-donating groups on the phenols were tolerated using these catalysts. No silver salts, acids, or solvents were needed for the catalysis, and either microwave or conventional heating afforded moderate to excellent yields of the vinyl ethers. ABSTRACT FOR PART II: ARYLGOLD(I) COMPOUNDS TO PROMOTE THE ADDITION OF DIPHENYLPHOSPHINIC ACID TO TERMINAL ALKYNES Arylgold compounds were investigated as single component catalysts for the addition of diphenylphosphinic acid to terminal alkynes using a microwave reactor. Both carbene and phosphine ligated compounds were
A mild strategy for highly regioselective hydration of the alkynes (internal and terminal) has been developed employing intramolecular ketone as the directing group under Ag(I) catalysis. were using acid to catalyze this transition. For terminal alkynes the addition of water follows the Markovnikov rule, as in the second example below, and the final product ia a methyl ketone ( except for acetylene, shown in the first example ). And then we have H2O and H2SO4 are If youre seeing this message, it means were having trouble loading external resources on our website. So this is my enol form. see a very similar reaction where we do a base-catalyzed mechanism for this arrangement in a few minutes here. Now the equilibrium is actually In contrast, the indirect hydration by the reaction sequence of hydroboration, oxidation and hydrolysis results in the anti-Markovnikov product. acid-catalyzed tautomerization. The first step is an acid/base reaction where the π electrons of the triple bond acts as a ...
Ligand lability offers a unique opportunity for access to metal-ligand cooperativity (MLC), helping to direct new organometallic and catalytic reactions. In recent years, ligand-assisted C-H bond activation and, more generally, proton migration have been of particular interest. This paper describes a detailed computational study into the mechanism, as well as the region and stereoselectivity, observed in a recently reported transformation where MLC in a 16-electron iridium(III) phosphoramidate complex plays a critical role in directing the activation of terminal alkynes toward the generation of novel five-membered (E)-vinyloxyirida(III)cycles. Five possible pathways for the formation of such products were investigated. Based on our findings, it is proposed that the reaction proceeds via a ligand-assisted proton shuttle (LAPS) mechanism, where the phosphoramidate phosphoryl (P=O) group assists in both alkyne C-H bond activation and C-H bond formation to form a vinylidene intermediate. Next, C-O ...
Poly(ethylene glycol) (PEG) is one of the most extensively studied antifouling coatings due to its ability to reduce protein adsorption and improve biocompatibility. Although the use of PEG for antifouling coatings is well established, the stability and density of PEG layers are often inadequate to provide optimum antifouling properties. To improve on these shortcomings, we employed the stepwise construction of PEG layers onto a silicon surface. Acetylene-terminated alkyl monolayers were attached to nonoxidized crystalline silicon surfaces via a one-step hydrosilylation procedure with 1,8-nonadiyne. The acetylene-terminated surfaces were functionalized via a copper-catalyzed azide-alkyne cycloaddition (CuAAC) reaction of the surface-bound alkynes with an azide to produce an amine terminated layer. The amine terminated layer was then further conjugated with PEG to produce an antifouling surface. The antifouling surface properties were investigated by testing adsorption of human serum albumin ...
In systematic chemical nomenclature, alkynes are named with the Greek prefix system without any additional letters. Examples include ethyne or octyne. In parent chains with four or more carbons, it is necessary to say where the triple bond is located. For octyne, one can either write 3-octyne or oct-3-yne when the bond starts at the third carbon. The lowest number possible is given to the triple bond. When no superior functional groups are present, the parent chain must include the triple bond even if it is not the longest possible carbon chain in the molecule. Ethyne is commonly called by its trivial name acetylene.. In chemistry, the suffix -yne is used to denote the presence of a triple bond. In organic chemistry, the suffix often follows IUPAC nomenclature. However, inorganic compounds featuring unsaturation in the form of triple bonds may be denoted by substitutive nomenclature with the same methods used with alkynes (i.e. the name of the corresponding saturated compound is modified by ...
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Jie Zhou,Jingjing Shi,Qi ZS,et al. Mild and Efficient Ir(III)-Catalyzed Direct C−H Alkynylation of N‑Phenoxyacetamides with Terminal Alkyne[J]. ACS Catalysis,2016,6(0):6999 ...
Various non-fluorescent alkynes for copper-catalyzed Click Chemistry. Fluorescent dye alkynes are listed under Reactive dyes category.
As you should know already, carbon is generally found in a tetravalent state - it forms four covalent bonds with other atoms. As you know from the section on alkenes, all four bonds are not necessarily to different atoms, because carbon atoms can double-bond to one another. What this does is create the appearance of only being bound to three other atoms, but in actuality four bonds exist. Alkenes are molecules that consist of carbon and hydrogen atoms where one or more pairs of carbon atoms participate in a double bond, which consists of one sigma (σ) and one pi (π) bond. Alkynes are also molecules consisting of carbon and hydrogen atoms, but instead of forming a double bond with only one sigma (σ) and one pi (π) bond, the alkyne has at least one pair of carbon atoms who have a σ and two π bonds -- a triple bond. The carbon-carbon triple bond, then, is a bond in which the carbon atoms share an s and two p orbitals to form just one σ and two π bonds between them. This results in a linear ...
Role of small molecules such as drugs or metabolites in cells is commonly studied by fluorescence microscopy in which a fluorescent label is attached to the molecule. However, fluorescent labels are typically large that often interfere with the normal cellular function of the molecule. To avoid the use of bulky fluorescent labels, we introduce a technique that uses a simple small chemical tag called alkyne consisting of two carbons connected by a triple bond. The alkyne-tagged molecule is imaged using Raman microscopy that detects the strong Raman signal from the CC triple bond stretching vibration (~2120 cm-1). Because the alkyne signal is located in the silent region of the cell (1800-2700 cm-1), it does not interfere with any intrinsic cellular Raman signals. Here, we demonstrate this technique by showing Raman images of an alkyne-tagged component of DNA in a living cell using a slit-scanning confocal Raman microscope. This fast imaging technique is based on a line-shaped focus illumination ...
Carbon-carbon double bonds are pretty common in nature, but triple bonds between carbons, called alkynes, are not. When alkynes...
Bioorthogonal chemistry was pioneered by Dr. Carolyn Bertozzi, a 2017 inductee into the National Inventors Hall of Fame. Her work in Immunology earned her--
Alkenes & Alkynes - Crash Course Chemistry #41 - lesson plan ideas from Spiral. Tagged under: Chemistry (Professional Field),crash ,chemistry,molecule,energy,chemical bonds,Leucippus,atomic theory, nucleus,organic chemistry,Organic Chemistry (Field Of Study),alkanes,isomers,structure,alkenes,alkynes,naming rules,cis trans isomerism,hydrogenation,halogenation,polymerization,triglycerides,names fats
Toxicocinétique et métabolisme Lalcool propargylique (Propargil Alkol, Propargyl Alcohol) est probablement métabolisé en aldéhyde propargylique. Cette oxydation a été démontrée in vitro dans des expériences avec la catalase obtenue à partir de foie de bovin. Des expériences in vitro avec des microsomes hépatiques de rats induits par le phénobarbital ont révélé de faibles niveaux de liaison de lalcool propargylique (Propargil Alkol, Propargyl Alcohol) au cytochrome P450 (BG Chemie 1999). 3 Effets chez lhomme Il ny a pas de données sur les effets chez lhomme dune exposition à lalcool propargylique (Propargil Alkol, Propargyl Alcohol). 262 Propargyl Alcohol (Propargil Alkol, Propargyl Alcohol) Volume 21 Propargyl Alcohol (Propargil Alkol, Propargyl Alcohol) 4 Expérimentation animale et études in vitro 4.1 Toxicité aiguë Lalcool propargylique (Propargil Alkol, Propargyl Alcohol) sest avéré toxique après administration orale, application cutanée et exposition par ...
LI-COR now offers a portfolio of Click Chemistry reagents for copper-catalyzed and copper-free methods. These products offer researchers flexibility to choose the correct reagent for a diverse array of applications. LI-COR Click Chemistry reagents include IRDye® 800CW, IRDye 680RD, and IRDye 650 infrared fluorescent dyes labeled with DBCO, azide, or alkyne groups. Click Chemistry utilizes pairs of reagents that exclusively react with each other and are effectively inert to naturally-occurring functional groups such as amines. Unlike affinity interactions such as streptavidin-biotin, Click Chemistry forges covalent bonds between the reacting partners to deliver stable bioconjugates.. Click Chemistry reactions can be categorized into two separate groups, copper-catalyzed or copper-free. Copper-catalyzed Click Chemistry is used for initiating reactions between azides and alkynes. These reactions are also known as Copper-Catalyzed Azide-Alkyne Cycloaddition (CuAAC). Although they initiate and ...
LI-COR now offers a portfolio of Click Chemistry reagents for copper-catalyzed and copper-free methods. These products offer researchers flexibility to choose the correct reagent for a diverse array of applications. LI-COR Click Chemistry reagents include IRDye® 800CW, IRDye 680RD, and IRDye 650 infrared fluorescent dyes labeled with DBCO, azide, or alkyne groups. Click Chemistry utilizes pairs of reagents that exclusively react with each other and are effectively inert to naturally-occurring functional groups such as amines. Unlike affinity interactions such as streptavidin-biotin, Click Chemistry forges covalent bonds between the reacting partners to deliver stable bioconjugates.. Click Chemistry reactions can be categorized into two separate groups, copper-catalyzed or copper-free. Copper-catalyzed Click Chemistry is used for initiating reactions between azides and alkynes. These reactions are also known as Copper-Catalyzed Azide-Alkyne Cycloaddition (CuAAC). Although they initiate and ...
Photo-mediated copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) click reactions for forming polymer networks as shape memory materials Journal Article ...
If you have a question about this talk, please contact .. The development of bioorthogonal reactions made it possible to visualize and study biomolecules in their native cellular context and contributed to advanced targeted drug delivery strategies. In our research group we are interested in developing novel bioorthogonal chemistry and apply this in the targeting of specific cell types. We recently added non-strained, highly soluble and stable vinylboronic acids (VBA) as reactants to the bioorthogonal toolbox which react with tetrazines in an inverse-electron demand Diels-Alder reaction. We have observed exceptional high reaction rates between non-strained vinylboronic acids (VBAs) and dipyridyl tetrazines relative to that of tetrazines lacking such dative coordinating ligand. As VBAs are mild Lewis acids, we hypothesize that coordination of the pyridyl to the boronic acid promotes the tetrazine ligation. In the current presentation, we explore the scope and molecular origins of the observed VBA ...
Nominated Substances: Propargyl alcohol. Nomination Date: 09/20/1996 Nominator: NCI Rationale: Propargyl alcohol is nominated for subchronic studies based on potential for human exposure and a suspicion of carcinogenicity. Propargyl alcohol is a high production volume chemical which is used mainly as a chemical intermediate for a variety of products. It has been identified in air, soil and solid waste. The suspicion of carcinogenicity is based on its metabolism to the aldehyde and positive results in genotoxicity studies. The hepatotoxicity observed in previous studies is similar to that produced by carbon tetrachloride. Chronic toxicity data is lacking. NTP Principles: 1, 2, 7. ...
Highlights Ni-Catalyzed Coupling Reactions Nickel-Catalyzed Coupling of Carbonyl Compounds and Alkynes or 1,3-Dienes: An Efficient Method for the Preparation of Allylic, Homoallylic, and Bishomoallylic Alcohols Shin-ichi Ikeda* Keywords: alcohols · C C coupling · catalysis · multicomponent reactions · nickel The alkenylation, allylation, and homoallylation of carbonyl compounds, which gives allylic, homoallylic, and bishomoallylic alcohols, respectively, are important processes in the formation of carbon-carbon bonds. However, in these approaches, the preparation of the corresponding alkenylating, allylating, and homoallylating reagents, which often requires troublesome procedures, is unavoidable.[1-5] Recently, new nickelcatalyzed coupling reactions of a carbonyl compound (e.g., aldehyde or ketone) and an unsaturated substrate (e.g., alkyne or 1,3-diene) with an organometallic or metal hydride have been reported, and these offer more efficient methods to give the desired alcohols without ...
Kataria, Meenal ; Deol, Harnimarta ; Singh, Gurpreet ; Kumar, Manoj ; Bhalla, Vandana (2018) Visible-light-mediated dehydrogenative cross-coupling between terminal alkynes and aldehydes by employing a supramolecular polymeric ensemble of PBI derivative New Journal of Chemistry, 42 (2). pp. 822-826. ISSN 1144-0546 Full text not available from this repository.. Official URL: http://pubs.rsc.org/en/content/articlelanding/2018.... Related URL: http://dx.doi.org/10.1039/C7NJ03557H ...
TY - JOUR. T1 - Isolated, well-defined organovanadium(III) on silica. T2 - Single-site catalyst for hydrogenation of alkenes and alkynes. AU - Sohn, H.. AU - Camacho-Bunquin, J.. AU - Langeslay, R. R.. AU - Ignacio-De Leon, P. A.. AU - Niklas, J.. AU - Poluektov, O. G.. AU - Liu, C.. AU - Connell, J. G.. AU - Yang, D.. AU - Kropf, J.. AU - Kim, H.. AU - Stair, P. C.. AU - Ferrandon, M.. AU - Delferro, M.. PY - 2017/1/1. Y1 - 2017/1/1. N2 - A well-defined, isolated, single-site organovanadium(iii) catalyst on SiO2 [(SiO2)V(Mes)(THF)] was synthesized via surface organometallic chemistry, and fully characterized using a combination of analytical and spectroscopic techniques (EA, ICP, 1H NMR, TGA-MS, EPR, XPS, DR-UV/Vis, UV-Raman, DRIFTS, XAS). The catalyst exhibits unprecedented reactivity in liquid-and gas-phase alkene/alkyne hydrogenation. Kinetic poisoning experiments revealed that 100% of the V sites are active for hydrogenation.. AB - A well-defined, isolated, single-site organovanadium(iii) ...
Rules for naming alkynes (molecules with a carbon-carbon triple bond). Created by Jay. Watch the next lesson: https://www.khanacademy.org/science/organic-chemistry/alkenes-alkynes/naming-preparation-alkynes/v/alkyne-acidity-and-alkylation?utm_source=YT&utm;_medium=Desc&utm;_campaign=organicchemistry Missed the previous lesson? https://www.khanacademy.org/science/organic-chemistry/alkenes-alkynes/alkene-reactions-tutorial/v/ozonolysis-1?utm_source=YT&utm;_medium=Desc&utm;_campaign=organicchemistry Organic Chemistry on Khan Academy: Carbon can form covalent bonds with itself and other elements to create a mind-boggling array of structures. In organic chemistry, we will learn about the reactions chemists use to synthesize crazy carbon based structures, as well as the analytical methods to characterize them. We will also think about how those reactions are occurring on a molecular level with reaction mechanisms. Simply put, organic chemistry is like building with molecular Legos. Lets make some
Huge advances have been made in the field of palladium catalyzed C-H activation in the past decade. The application of palladium catalyzed C-H activation to form complex, multifunctional substrates, especially directly C-H alkynylation are positively exploring. We have recently successfully elucidated a series of palladium catalyzed C-H alkynylation from commercial available material. These transformations included synthesis of highly substituted cyclopentadiene fused chromones from cascade reactions of coumarins with alkynes and C¿H/N¿H dual activation to synthesize benzazepines from isatin and alkynes; Recent years have witnessed an explosive growth in the field of iminium and enamine catalysis. Primary and secondary amines as catalysis in the cycloaddition transformation of biological and pharmaceutical compounds via the iminmium activation model have been greatly explored. We have successfully explored a series of enamine catalyzed [3+2] cycloaddition. These pioneering works consisted by ...
The Sonogashira reaction is a cross-coupling reaction used in organic synthesis to form carbon-carbon bonds. It employs a palladium catalyst to form a carbon-carbon bond between a terminal alkyne and an aryl or vinyl halide. R − ≡ − H + R ′ − X → base, rt Pd cat., Cu cat. R − ≡ − R ′ {\displaystyle {\begin{matrix}{}\\{\ce {R-\!{\equiv }\!-H}}+{\color {Red}{\ce {R}}}\!-\!{\ce {X->[{\text{Pd cat., Cu cat.}}][{\text{base, rt}}]R-\!{\equiv }\!}}{\color {Red}{\ce {-R}}}\end{matrix}}} R: Aryl or Vinyl X: I, Br, Cl or OTf The Sonogashira cross-coupling reaction has been employed in a wide variety of areas, due to its usefulness in the formation of carbon-carbon bonds. The reaction can be carried out under mild conditions, such as at room temperature, in aqueous media, and with a mild base, which has allowed for the use of the Sonogashira cross-coupling reaction in the synthesis of complex molecules. Its applications include pharmaceuticals, natural products, organic materials, ...
The Sonogashira reaction is a cross-coupling reaction used in organic synthesis to form carbon-carbon bonds . It employs a palladium catalyst to form a carbon-carbon bond between a terminal alkyne and an aryl or vinyl halide . The Sonogashira cross-coupling reaction has been employed in a wide variety of areas, due to its usefulness in the formation of carbon-carbon bonds. The reaction can be carried out under mild conditions, such as at room temperature, in aqueous media, and with a mild base, which has allowed for the use of the Sonogashira cross-coupling reaction in the synthesis of complex molecules. Its applications include pharmaceuticals, natural products, organic materials, and nanomaterials. Specific examples include its use in the synthesis of tazarotene , which is a treatment for psoriasis and acne , and in the preparation of SIB-1508Y, also known as Altinicline , which is a potential treatment for Parkinson's disease , Alzheimer's disease , Tourette syndrome , schizophrenia ,
The 1,3-dipolar cycloaddition of trifluoromethylated propargylic alcohols 1 with azides in the presence of catalytic [Cp*RuCl2], afforded exclusively 4-trifluoroniethyl-1,4,5-trisubstituted-1,2,3-triazoles 2 in high yields. (c) 2008 Elsevier Ltd. All rights reserved ...
see article for more reactions. Abstract. A highly efficient oxidation of propargylic alcohols to ynones is catalyzed by copper nanoparticles (Cu Nps) with TBHP or air as oxidants. With bipyridine as the ligand, the reaction was accelerated significantly and led in good to excellent yields to a variety of propargylic alcohols.. ...
Mild and efficient synthesis of ynones via Ir(III)- and Rh(III)-catalyzed, chelation-assisted formyl C-H alkynylation of benzaldehydes has been achieved using hypervalent iodine-alkyne reagents. Rhodium and iridium catalysis exhibited complementary substrate scope ...
Speziali MG, Monteiro AL. Synthesis of Imidazole-Derived Ionic Liquids from Monoterpenes by Means of the Sonogashira Reaction. Synthesis-StuttgartSynthesis-StuttgartSynthesis-Stuttgart. 2012;44:3505-3511.
Prof. Echavarrens group presents the first general enantioselective synthesis of cyclobutenes by intermolecular [2+2] cycloadditions. Digold complexes catalyse the reaction between terminal alkynes and alkenes leading to chiral cyclobutenes, useful in organic chemistry because they can be hydrogenated into functionalised cyclobutanes, which are motifs present in a variety of natural products and pharmaceuticals.. Previous attempts to achieve this transformation required activated alkynes or strained alkenes. The new strategy developed at ICIQ works for an enormous variety of terminal alkynes and a myriad of both disubstituted and trisubstituted alkenes. In total, this gold-catalysed reaction was used to synthesize a scope of over 40 different products, all with good yields and excellent enantiomeric ratios.. Due to the linear geometry of gold(I) complexes, chiral ligands are usually far away from the reaction centre. Hence, finding the gold catalysts that yield enantioselective transformations ...
M. Konkol, H. Schmidt, D. Steinborn, J. Mol. Catal. A: Chemical 2007, 261, 301 - 305. „Iridium-catalyzed addition of methanol to internal alkynes. ___________________________________________________________. M. Konkol, H. Schmidt, D. Steinborn, J. Mol. Catal. A: Chemical 2007, 269, 119 - 124. „Iridium-catalyzed addition of methanol to terminal alkynes ___________________________________________________________. M. Vavra, I. Potočň k, M. Dušek, K. Fejfarov , C. Wagner, D. Steinborn, Achievements in Coordination, Bioinorganic and Applied Inorganic Chemistry (Eds. M. Melnik, J. ima, M. Tatarko), STU Press, Bratislava, 2007, 333 - 344 ...
Organic compounds that contain nitrogen are very important intermediates in pharmaceutical and chemical industry. Hydroamination is the reaction that can form C-N bond with high atom economy. The research progress in metals catalyzed hydroamination of alkenes and alkynes from the perspective of reaction mechanism is categorized and summarized.
Mentioning: 12 - An efficient protocol for the direct transformation of chroman-4-ones to tricyclic fused pyridines with the skeleton of cassiarins, a family of alkaloids with antimalarial activity, was developed. Also, a general strategy for modular construction of polyheterocycles with diverse natural product-like skeletons was developed by using ketone-alkyne bifunctional substrates. These reactions involved a one-pot cascade oximation of ketones, rhodium-catalyzed C-H activation, and intermolecular/intramolecular alkyne annulations under mild conditions with high atom, step, and redox economy.
A catalytic hydroamidation of alkynes with isocyanates using alkyl bromides as hydride sources has been developed. The method turns parasitic β-hydride elimination into a strategic advantage, rapidly affording acrylamides with excellent chemo- and regioselectivity.. ...
A series of bis(amidate)group 4-bis(amido) complexes have been prepared, characterized and have been shown to be highly tunable precatalysts for both the intra- and intermolecular hydroamination of alkynes.. ...
TY - JOUR. T1 - Naphthoquinones from alkynes and chromium-carbene complexes-control of regioselectivity through intramolecular reaction. AU - Semmelhack, Martin F.. AU - Bozell, Joseph J.. PY - 1982/1/1. Y1 - 1982/1/1. N2 - A series of carbene-chromium complexes bearing a phenyl substituent and an alkoxy-alkyne substituent have been prepared by acetoxy replacement. Intramolecular cycloaddition with carbon monoxide insertion occurs to provide naphthohydroquinones in good yield.. AB - A series of carbene-chromium complexes bearing a phenyl substituent and an alkoxy-alkyne substituent have been prepared by acetoxy replacement. Intramolecular cycloaddition with carbon monoxide insertion occurs to provide naphthohydroquinones in good yield.. UR - http://www.scopus.com/inward/record.url?scp=0000695788&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0000695788&partnerID=8YFLogxK. U2 - 10.1016/S0040-4039(00)87497-3. DO - 10.1016/S0040-4039(00)87497-3. M3 - Article. AN - ...
A novel strategy to obtain side chain modified poly(oxindole biphenylylene) (POXI) by photoinduced copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) click reaction is described. In the first step, an alkyne-functionalized poly(oxindolebiphenylylene) (POXI-alkyne) is synthesized by superacid-catalyzed condensation of isatin with aromatic hydrocarbons. Subsequently, poly(ethylene glycol) methyl ether (Me-PEG), 1-pyrenemethanol (Py-OH) and 1,3-dibromopropane (DBP) are functionalized by azide groups via simple nucleophilic substitution reaction. Visible-light-induced CuAAC reaction between POXI-alkyne and the corresponding azide functionalized click components employing dibenzoyldiethylgermane (DBDEG) as photoactivator resulted in the formation of POXI-PEG, POXI-Py and insoluble network, respectively. Successful modification of POXI was confirmed by the spectral, (1H NMR, FT-IR, Fluorescence), chromatographic (GPC) and thermal (DSC) investigations ...
Interdisciplinary Nanoscience Center - INANO-Fysik, iNANO-huset, Interdisciplinary Nanoscience Center, Science and Technology, Aarhus ...
TY - JOUR. T1 - Precise grafting of macrocyclics and dendrons to a linear polymer chain. AU - Amir, Faheem. AU - Hossain, Md D.. AU - Jia, Zhongfan. AU - Monteiro, Michael J.. PY - 2016/8/31. Y1 - 2016/8/31. N2 - Sequential growth of multifunctional telechelic polymer chains was used here to produce three, four or seven HO-functionalities equally spaced along the polymer backbone. The telechelic building block consisted of a halide group on one end and both a hydroxyl and alkyne group on the other end. The key was to maintain the halide end-group on the telechelic polymer chain during the CuAAC coupling reaction after each sequential growth. This was accomplished by using the combination of the PMDETA ligand and toluene as a solvent to produce significantly faster rates of CuAAC coupling reaction over halide abstraction. The HO-functionalities were then converted to azide groups allowing further CuAAC reactions with either alkyne polymeric dendrons or cyclics to produce equally spaced grafts ...
Free Notes on Alkanes, Alkenes and Alkynes - KCET Engineering. Read all the Important points and Chapterwise Notes on KCET Engineering
Reactions of 2-pyrone (2P) and 1,4-oxazinone (OXZ) with hetero alkynes viz., phosphines (HA1) and silanes (HA2) have been scanned at B3LYP/6-31G(d) level.
Acetylene is a weak acid, but not nearly as weak as alkanes or alkenes. CompoundpK a HF3.2 H 2 O16 NH CH 4 60 H2CH2CH2CH2C CH 2 HCCH 26 Acetylene
These are dPEG® compounds from Quanta Biodesign that contain discrete length PEGs. This can improve reproducibility in experiments when compared to using PEGs of variable length. PEGS have high aqueous solubility and a substances aqueous solubility can be improved by attaching a PEG. Some of these compounds contain a single reactive end for attachment to proteins such as through amines or sulfhydryls. This list includes branched PEGs which are more compact than long linear PEGs. There are also compounds with two reactive ends for crosslinking. Some of the compounds have azide groups which can be attached to alkynes using copper click chemistry or to strained alkynes through copper-free click chemistry. Some of the compounds have a biotin on one end for capture by avidins. Overall the many options offered by these dPEG® products can enable a variety of biconjugation applications.
Vancomycin is the last resort antibiotic against MRSA. Vancomycin causes the bacteria to die by physically blocking a recognition site within the cell wall. This recognition site binds to the inner cavity of vancomycin, which consists of a rigid bicyclic structure. The objective of my research was to mimic this ... read more bicyclic structure using synthetic alkene and alkyne bridges, and to see if a similar cavity was obtained. The alkene bridges were introduced using a (tandem) ring-closing metathesis reaction and the alkyne bridges were introduced by a Sonogashira reaction. show less ...
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The copper (I)-catalyzed alkyne azide 1,3-dipolar cycloaddition (CuAAC) or click reaction, is a highly versatile reaction that can be performed under a variety of reaction conditions including various solvents, a wide pH and temperature range, and using different copper sources, with or without additional ligands or reducing agents. This reaction is highly selective and can be performed in the presence of other functional moieties. The flexibility and selectivity has resulted in growing interest in the application of CuAAC in various fields. In this review, we briefly describe the importance of the structural folding of peptides and proteins and how the 1,4-disubstituted triazole product of the CuAAC reaction is a suitable isoster for an amide bond. However the major focus of the review is the application of this reaction to produce peptide conjugates for tagging and targeting purpose, linkers for multifunctional biomacromolecules, and reporter ions for peptide and protein analysis.
Two types of multiarm star block copolymers: (polystyrene)(m)-poly(divinylbenzene)-poly(methyl methacrylate)(n), (PS)(m),-polyDVB-(PMMA)(n) and (polystyrene)(m)-poly(divinylbenzene)-poly(tert-butyl acrylate)(k), (PS)(m)-polyDVB-(PtBA)(k) were successfully prepared via a combination of cross-linking and Diels-Alder click reactions based on arm-first methodology. For this purpose, multiarm star polymer with anthracene functionality as reactive periphery groups was prepared by a cross-linking reaction of divinyl benzene using a-anthracene end functionalized polystyrene (PSAnth) as a macroinitiator. Thus, obtained multiarm star polymer was then reacted with furan protected maleimide-end functionalized polymers: PMMA-MI or PtBA-MI at reflux temperature of toluene for 48 h resulting in the corresponding multiarm, star block copolymers via Diels-Alder click reaction. The multiarm star and multiarm star block copolymers were characterized by using H-1 NMR, SEC, Viscotek triple detection SEC (TD-SEC) ...
0)non-5-ene (DBN). 14). 14 Tertiary-amine-catalyzed thiol-isocyanate click reaction. 3 Thiol-Michael Addition Click Reactions Hydrothiolation of C==C double bond can be performed in the presence of mild bases or using nucleophilic catalysis. Unlike thiol-ene radical reaction (which can proceed with almost all olefins), thiol Michael addition reactions require activated carbon-carbon double bonds, which are in conjugation with an EWG. In the presence of trialkylamine bases such as NEt3 , the reaction proceeds smoothly to give the addition products in very high yields. This family includes 15 isoenzymes (I-XIV, V further subclassified as VA and VB) endowed with different molecular features, cellular localization, distribution in organs and tissues, and kinetic properties. It has been demonstrated that the dysfunction of these enzymes is related to different pathologies such as cancer (CAs VII, IX, XII), neurodegeneration (CA VIII), obesity (CAs VA and VB), and sterility (CA XIII) [36]. 3). 76) ...
TY - JOUR. T1 - Rearrangement of indene skeletons under mild conditions. AU - Kuninobu, Yoichiro. AU - Ueda, Hirokazu. AU - Kawata, Atsushi. AU - Takai, Kazuhiko. PY - 2007/8/31. Y1 - 2007/8/31. N2 - (Chemical Equation Presented) Isomerization between two isomers of 1,2-disubstituted 3-aminoindenes occurs via the rearrangement of indene frameworks. In contrast to previous rearrangements of indene derivatives, which occur under high-temperature conditions or the irradiation of light, this rearrangement proceeds at room temperature without UV light irradiation. An amino group at the 3-position plays an important role to accelerate the rearrangement under mild conditions.. AB - (Chemical Equation Presented) Isomerization between two isomers of 1,2-disubstituted 3-aminoindenes occurs via the rearrangement of indene frameworks. In contrast to previous rearrangements of indene derivatives, which occur under high-temperature conditions or the irradiation of light, this rearrangement proceeds at room ...
The therapeutic efficacy of antibodies can be successfully improved through targeted delivery of potent cytotoxic drugs in the form of antibody-drug conjugates. However, conventional conjugation strategies lead to heterogeneous conjugates with undefined stoichiometry and sites, even with considerable batch-to-batch variability. In this study, we have developed a chemo-enzymatic strategy by equipping the C-terminus of anti-CD20 ofatumumab with a click handle using Sortase A, followed by ligation of the payload based on a strain-promoted azide-alkyne cycloaddition to produce homogeneous conjugates. The resulting antibody-drug conjugates fully retained their antigen binding capability and proved to be internalized and trafficked to the lysosome, which released the payload with a favorable efficacy in vitro and in vivo. Thus, this reported method is a versatile tool with maximum flexibility for development of antibody-drug conjugates and protein modification.
Methods for selective protein imaging are critical for elucidating how cells orchestrate fundamental biological processes. We recently developed a chemoenzymatic method to modify bacterial proteins in situ for fluorescence imaging using N-myristoyl transferase (NMT). Target proteins outfitted with an N-terminal NMT recognition sequence are covalently modified with an azido fatty acid. Subsequent strain-promoted azide-alkyne cycloaddition allows for conjugation to cell-permeant fluorophores and imaging by fluorescence microscopy. Here we describe sample preparation and labeling protocols for imaging bacterial proteins in fixed and live cells. ...
Prof. Aiwen Lei and coworkers, Wuhan University, Hubei, have developed a silver catalyst click reaction for the synthesis of pyrrole, by cycloaddition. This system benefits from readily-available starting materials, low catalyst loading (0.1 eq), short reaction times (2 h) and excellent chemo-selectivity. And, works for both internal and alkyl substituted terminal alkynes in the presence of many functional groups. The extremely mild conditions used, makes this reaction synthetically attractive ...
0018] Compounds of formula (I) and (III) wherein the vector is a peptide or protein may be prepared by standard methods of peptide synthesis, for example, solid-phase peptide synthesis, for example, as described in Atherton, E. and Sheppard, R. C.; Solid Phase Synthesis; IRL Press: Oxford, 1989. Incorporation of the alkyne or azide group in a compound of formula (I) or (III) may be achieved by reaction of the N or C-terminus of the peptide or with some other functional group contained within the peptide sequence, modification of which does not affect the binding characteristics of the vector. The alkyne or azide groups are preferably introduced to a compound of formula (I) or (III) by formation of a stable amide bond, for example formed by reaction of a peptide amine function with an activated acid or alternatively reaction of a peptide acid function with an amine function and introduced either during or following the peptide synthesis. Methods for incorporation of the alkyne or azide group ...
Alkynes form complexes with transition metals. Such complexes occur also in metal catalyzed reactions of alkynes such as alkyne ... Look up alkyne in Wiktionary, the free dictionary. Wikiquote has quotations related to Alkyne. -yne cycloalkyne Alkyne. ... Cycloaddition processes involving alkynes are often catalyzed by metals, e.g. enyne metathesis and alkyne metathesis, which ... Electrophilic alkynes are especially effective dienophiles. The "cycloadduct" derived from the addition of alkynes to 2-pyrone ...
Alkyne trimerization is of no practical value, although the reaction was highly influential. The cotrimerization of alkynes and ... In organic chemistry, an alkyne trimerisation is a [2+2+2] cycloaddition reaction in which three alkyne units (C≡C) react to ... In terms of mechanism, the reactions begin with the formation of metal-alkyne complexes. The combination of two alkynes within ... Many variations have been developed, including cyclisation of mixtures of alkynes and alkenes as well as alkynes and nitriles. ...
... can be used in ring-closing operations and RCAM stands for ring closing alkyne metathesis. The olfactory ... Alkyne metathesis is an organic reaction that entails the redistribution of alkyne chemical bonds. The reaction requires metal ... Catalysts for alkyne metathesis "canopy catalysts" Air stable low-valent d2 rhenium alkylidyne various Schrock-based alkyne ... Ritter, S. (March 26, 2007). "Nitrile-Alkyne Cross-Metathesis". Chemical & Engineering News. Alkyne Metathesis in Organic ...
The alkyne zipper reaction is an organic reaction that involves isomerization of a non terminal alkyne into a terminal alkyne. ... essentially moving the alkyne along the alkane chain until a terminal alkyne is achieved. Once a terminal alkyne is achieved, ... 8, p. 146 "Alkyne Zipper Reaction". SynArchive. 2017. Archived from the original on 2011. Retrieved December 19, 2017. ( ... The conversion provides a useful approach for remote functionalization in long-chain alkynes. The reaction requires a strong ...
... es are often formed by the displacement of labile ligands by the alkyne. For example, a variety ... This kind of bonding was first implicated in complexes of the type W(CO)(R2C2)3. Because alkynes have two π bonds, alkynes can ... Metal alkyne complexes are intermediates in the semihydrogenation of alkynes to alkenes: C2R2 + H2 → cis-C2R2H2 This ... In organometallic chemistry, a transition metal alkyne complex is a coordination compound containing one or more alkyne ligands ...
The azide-alkyne Huisgen cycloaddition is a 1,3-dipolar cycloaddition between an azide and a terminal or internal alkyne to ... Unlike CuAAC in which only terminal alkynes reacted, in RuAAC both terminal and internal alkynes can participate in the ... While the copper(I)-catalyzed variant gives rise to a triazole from a terminal alkyne and an azide, formally it is not a 1,3- ... The copper (I) species generated in situ forms a pi complex with the triple bond of a terminal alkyne. In the presence of a ...
"Mechanistic Studies on the Reaction of Fischer Carbene Complex with Alkynes: Does the Alkyne Insertion Intermediate Form ... and alkynes. Walters graduated from Chicago in 1997 with a PhD in chemistry. She was an NIH postdoctoral fellow in Prof. Ronald ...
"Hydration of Alkynes". Chem LibreTexts. May 2, 2019. Retrieved May 6, 2019. "Reactions of Alkynes - Addition of HX and X2". ... Alkynes, under metal catalysts, for example cobalt, can also go under cycloaddition reaction called alkyne trimerization. Three ... The DCD model can also describe the alkyne ligand structure. Metal complex can also be intermediate of trimerization of alkynes ... The hydrohalogenation of alkyne is much slower than the alkene. The reaction equation of HBr addition to ethene is: H2C=CH2 + ...
Ouellette, Robert J.; Rawn, J. David (2015). "Alkenes and Alkynes". Principles of Organic Chemistry. pp. 95-132. doi:10.1016/ ... being the only isomer that can reduce alkenes and alkynes to alkanes, but for a different reason: the trans isomer cannot line ...
The thiol-yne reaction (also known as alkyne hydrothiolation) is an organic reaction between a thiol and an alkyne. The ... Diphenyl disulfide reacts with alkynes to a 1,2-bis(phenylthio)ethylene. Reported alkynes are ynamides. A photoredox thiol-yne ... Yadav, J. S.; Reddy, B. V. Subba; Raju, A.; Ravindar, K.; Baishya, Gakul (2007). "Hydrothiolation of Unactivated Alkynes ... Weiss, Charles J.; Wobser, Stephen D.; Marks, Tobin J. (2009). "Organoactinide-Mediated Hydrothiolation of Terminal Alkynes ...
Also sometimes designed as ethinyl in compounds (ethinylestradiol, ethisterone (ethinyltestosterone)). See main page alkynes. ...
This reaction is used to protect alkynes: the alkyne is either converted with acetone to a 2-hydroxyprop-2-yl-alkyne or a ... A metal acetylide is formed in situ when an alkyne is treated with a strong bases such as a hydroxide or an alkoxide: HC≡CH + ... 3.0.CO;2-R. Wuts, Peter G. M.; Greene, Theodora W. (2007). "Chapter 8. Protection for the Alkynes". Greene's Protective Groups ... The Favorskii reaction is an organic chemistry reaction between an alkyne and a carbonyl group, under basic conditions. The ...
By hydration of alkynes. Such processes occur via enols and require the presence of an acid and mercury(II) sulfate (HgSO4). ... This equilibrium allows ketones to be prepared via the hydration of alkynes. C−H bonds adjacent to the carbonyl in ketones are ... Ketones containing alkene and alkyne units are often called unsaturated ketones. The most widely used member of this class of ... This reaction always produces a ketone, even with a terminal alkyne, the only exception being the hydration of acetylene, which ...
Alkyne Is an unsaturated hydrocarbon containing at least one carbon-carbon triple bond. The simplest acyclic alkynes with only ... ISBN 978-1-4058-5345-3. Alkyne. Encyclopædia Britannica Callister, W. D. "Materials Science and Engineering: An Introduction" ...
alkyne In organic chemistry, an unsaturated hydrocarbon containing at least one carbon-carbon triple bond. alloy A combination ... ISBN 978-1-4058-5345-3. Alkyne. Encyclopædia Britannica Callister, W. D. "Materials Science and Engineering: An Introduction" ...
Substrates for hydrozirconation are alkenes and alkynes. Terminal alkynes give vinyl complexes. Secondary reactions are ...
Trimethyl Silyl (TMS) protected alkynes, trimethyl germanium alkynes, and terminal alkynes can produce anti-carboalumination ... This zirconium cation can coordinate an alkene or alkyne where migratory insertion of a methyl then takes place. The resultant ... Carbometalations can be performed on alkynes and alkenes to form products with high geometric purity or enantioselectivity, ... Novel syntheses of .alpha.,.beta.-unsaturated cyclopentenones via allylzincation of alkynes". Journal of the American Chemical ...
In 1991, Utimoto reacted gold(III) (NaAuCl4) with alkynes and water. Teles identified a major drawback of this method as Au(III ... Norman, R. O. C.; Parr, W. J. E.; Thomas, C. B. (1976). "The reactions of alkynes, cyclopropanes, and benzene derivatives with ... Cationic gold(I) forms π-complexes with alkene or alkyne bonds, following the Dewar-Chatt-Duncanson model. Gold is certainly ... For instance, Hashmi reported an AuCl3-catalyzed alkyne / furan Diels-Alder reaction - a type of cycloaddition that does not ...
Similar reactions occur involving alkynes. Base is not required for electron-deficient alkenes (e.g., derivatives of ... "Nucleophilic and free-radical additions of phosphines and phosphine chalcogenides to alkenes and alkynes". Arkivoc. v (5): 12- ... acrylonitrile) and alkynes. Secondary (2°) phosphines, with the formula R2PH, are prepared analogously to the primary ...
The generation of nitrogen gas gives a vinyl carbene G, which via a 1,2-migration forms the desired alkyne H. The dimethyl ( ... A facile synthesis of alkynes". J. Org. Chem. 47 (10): 1837-1845. doi:10.1021/jo00349a007. D. G. Brown; E. J. Velthuisen; J. R ... S. Müller; B. Liepold; G. Roth & H. J. Bestmann (1996). "An Improved One-pot Procedure for the Synthesis of Alkynes from ... Reaction of Bestmann's reagent with aldehydes gives terminal alkynes often in very high yield and fewer steps than the Corey- ...
The four main categories are (1) nucleophilic attack on an alkene alkyne, or allyl ligand and (2) insertion of the alkene into ... Pohlki, F.; Doye, S. (2003). "The catalytic hydroamination of alkynes". Chem. Soc. Rev. 32: 104-114. doi:10.1039/b200386b. PMID ... Alonso, F.; Beletskaya, I.P.; Yus, M. (2004). "Transition-Metal-Catalyzed Addition of Heteroatom−Hydrogen Bonds to Alkynes". ... The unsaturated substrates that have been investigated include alkenes, dienes, alkynes, and allenes. For intramolecular ...
Other kinds of alkynes produced polymers with this treatment. With alkenes, similarly bis(difluorophosphino) is added across ... Under ultraviolet light diphosphorus tetrafluoride reacts with alkynes connected to trifluoromethyl groups to add ... "Photoreactions of tetrafluorodiphosphine with alkynes". Journal of Fluorine Chemistry. 40 (1): 41-49. doi:10.1016/S0022-1139(00 ...
Lewis, L. N.; Sy, K. G.; Bryant, G. L.; Donahue, P. E. (1991). "Platinum-catalyzed hydrosilylation of alkynes". Organometallics ...
Various aromatic alkynes can be employed to yield desired disubstituted products with satisfactorily yields. Aliphatic alkynes ... It is suggested that the presence of a base results in the formation of a π-alkyne complex E. This increases the acidity of the ... It employs a palladium catalyst as well as copper co-catalyst to form a carbon-carbon bond between a terminal alkyne and an ... Copper(I) salts, such as CuI, react with the terminal alkyne and produce a copper(I) acetylide, which acts as an activated ...
The typical Pd-based catalyst is tetrakis(triphenylphosphine)palladium(0). The typical unsaturated substrates are alkynes. The ...
R. J. Rahaim & J. T. Shaw (2008). "Zinc-Catalyzed Silylation of Terminal Alkynes". J. Org. Chem. 73 (7): 2912-2915. doi:10.1021 ... "Silylation of 1-alkynes with chlorosilanes promoted by Zn(OTf)2: an efficient way to the preparation of alkynylsilanes". ...
It is a terminal alkyne. A colorless liquid, 1-decyne is used as a model substrate when evaluating methodology in organic ... Ishiyama, Tatsuo; Matsuda, Nobuo; Miyaura, Norio; Suzuki, Akira (1993). "Platinum(0)-Catalyzed Diboration of Alkynes". Journal ... of Azides and Terminal Alkynes". Angewandte Chemie International Edition. 41 (14): 2596-2599. doi:10.1002/1521-3773(20020715)41 ...
The reaction with the electron-poor alkyne (C6F5)CC(C6F5) required rather harsh reaction conditions (110 °C, 7 days) and the ... In that study, 2 was reacted with three differently substituted alkynes that greatly differed in their electronic properties, ... towards alkynes in great detail. Of particular relevance was the question of whether the enhanced Lewis acidity of 2 compared 1 ... The potent Lewis acidity of 12 revealed a novel reaction pathway whereby the alkyne first adds to the borole nucleophilically, ...
Like alkynes, iminoboranes bind transition metals. Paetzold, Peter; Plotho, Christoph Von; Schmid, Günter; Boese, Roland; ...
September 2011). "Bioconjugation with strained alkenes and alkynes". Acc Chem Res. 44 (9): 805-15. doi:10.1021/ar200059z. PMID ...
... Bathoju Chandra Chary and Sunggak Kim*. *Division of Chemistry and ... PPh3AuCl/AgPF6-catalyzed hydroacyloxylation of alkynes with carboxylic acids affords the Markonikov addition products, whereas ...
This work represents our initial effort in identifying azide/alkyne pairs for optimal reactivity in copper-catalyzed azide- ... alkyne cycloaddition (CuAAC) reactions. In previous works, we have identified chelating azides, in particular 2-picolyl azide, ... Choice of Alkynes. The tested alkynes are separated in three categories: (a) electron-withdrawing group-bearing alkynes (Figure ... Alkynes 20 and 21 were reexamined with the rest of alkynes at the original substrate concentrations (10 mM each for alkyne and ...
... Author:. Albrecht, Florian. Rey Vieites, Dulce María. Fatayer ... We used voltage pulses from the tip to trigger a Glaser‐like coupling between terminal alkyne carbons within a custom‐ ... Glaser‐like coupling of terminal alkynes by thermal activation is extensively used in on‐surface chemistry. Here we demonstrate ...
TF3 alkyne], a biochemical for proteomics research, from Santa Cruz Biotechnology. , Molecular Weight: 495.57 ... Tide Fluor™ 3 alkyne [TF3 alkyne] *bvseo_sdk, java_sdk, bvseo-3.2.0 ... Tide Fluor™ 3 alkyne [TF3 alkyne] is a strong fluorescent dye used for labeling peptides and nucleotides. ...
Click Reagents by Chemistry Alkyne Reagents Fluorescent Dyes ... Sulfo-Cy5-Alkyne. Abs/Em = 647/663 nm. bis(Triethylammonium) ... You are here: Click Chemistry , Click Reagents by Chemistry , Alkyne Reagents , Fluorescent Dyes , Sulfo-Cy5-Alkyne ... Gutman et al. (2016) Biocompatible Azide-Alkyne "Click" Reactions for Surface Decoration of Glyco-Engineered Cells. Chembiochem ...
The cobalt alkyne complex [(prop-2-ynyl)-2-acetoxybenzoate]dicobalthexacarbonyl (Co-ASS) is an auspicious lead, which exhibits ... Fluorination as tool to improve bioanalytical sensitivity and COX-2-selective antitumor activity of cobalt alkyne complexes† ... The cobalt alkyne complex [(prop-2-ynyl)-2-acetoxybenzoate]dicobalthexacarbonyl (Co-ASS) is an auspicious lead, which exhibits ... Fluorination as tool to improve bioanalytical sensitivity and COX-2-selective antitumor activity of cobalt alkyne complexes D. ...
Lower alkynes upto four carbon atoms are gases, those containing five to thirteen carbon atoms are liquids while higher alkynes ... Alkynes have physical properties similar to alkanes and alkenes. ... 3. Alkynes are sparingly soluble in polar solvents such as ... Lower alkynes upto four carbon atoms are gases, those containing five to thirteen carbon atoms are liquids while higher alkynes ... 1. Alkynes have physical properties similar to alkanes and alkenes. ...
Palladium nanoparticle catalysts in ionic liquids: synthesis, characterisation and selective partial hydrogenation of alkynes ... Palladium nanoparticle catalysts in ionic liquids: synthesis, characterisation and selective partial hydrogenation of alkynes ...
Reactions of the mixed-metal alkyne-bridged complexes [(η5-C5H5)(OC)2M{μ-C 2(CO2Me)2}Co(CO)3] (M=Mo or W) with Ph2PCCtBu1. In: ... Reactions of the mixed-metal alkyne-bridged complexes [(η5-C5H5)(OC)2M{μ-C 2(CO2Me)2}Co(CO)3] (M=Mo or W) with Ph2PCCtBu1. / ... Reactions of the mixed-metal alkyne-bridged complexes [(η5-C5H5)(OC)2M{μ-C 2(CO2Me)2}Co(CO)3] (M=Mo or W) with Ph2PCCtBu1. ... Reactions of the mixed-metal alkyne-bridged complexes [(η5-C5H5)(OC)2M{μ-C 2(CO2Me)2}Co(CO)3] (M=Mo or W) with Ph2PCCtBu1. ...
... Stuart Cook, Douglas Henderson, Kevan A. ... The synthesis of heteroaromatic prostacyclin analogues via keto alkyne cyclisation. , Journal of the Chemical Society Perkin ...
Bifunctional 4-Arm PEG-Alkyne/NHS reagents have two functional groups Alkyne and NHS ester at specific ratios of 1:3, 2:2, 3:1 ... Bifunctional 4-Arm PEG-Alkyne/NHS reagents have two functional groups Alkyne and NHS ester at specific ratios of 1:3, 2:2, 3:1 ... The alkyne and NHS ester functionality are quantitated using spectroscopic techniques and colorimetric assays. The NHS ester is ...
One-Pot Synthesis of CF3-Substituted Pyrazolines/Pyrazoles from Electron-Deficient Alkenes/Alkynes and CF3CHN2 Generated in ... One-Pot Synthesis of CF3-Substituted Pyrazolines/Pyrazoles from Electron-Deficient Alkenes/Alkynes and CF3CHN2 Generated in ... The [3+2] cycloaddition of CF3CHN2, generated in situ, with electron-deficient alkenes/alkynes affords CF3-substituted ...
Applicated in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound. ...
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Copper-catalyzed fluoroalkylation of alkynes and alkynyl carboxylic acids has been achieved with high functional-group ... Copper-catalyzed fluoroalkylation of alkynes, and alkynyl & vinyl carboxylic acids with fluoroalkyl halides. Jing-Jing Ma, Wen- ... Copper-catalyzed fluoroalkylation of alkynes and alkynyl carboxylic acids has been achieved with high functional-group ...
our alkenes alkynes are those which have at least one double bond at least one double bond have like it was a single point ... carbon atoms c2h -2 that is c2h means the general Formula for alkynes and it is also a type of unsaturated hydrocarbon hydro ... hydrocarbon and saturated a dose of the double bond and triple let us discuss alkine sunao water alkenes alkynes are those ... hi everyone lets take a questionnaire the question is how will you distinguish between alkanes alkenes and alkynes have to ...
Whereas the azide-alkyne approach may be suffered from the potential danger in handling azides on large scale, the ATRP graft ... In the first strategy, thermal azide-alkyne Huisgen cycloaddition was utilized to attach electron-poor acetylenediamides using ... Internal Plasticization of Poly(Vinyl Chloride) using Thermal Azide-Alkyne Huisgen Cycloaddition and Copper-Mediated Atom ...
Rungta, Parul, "Utilizing Copper(I) Catalyzed Azide-Alkyne Huisgen 1,3-Dipolar Cycloaddition for the Surface Modification of ... Utilizing Copper(I) Catalyzed Azide-Alkyne Huisgen 1,3-Dipolar Cycloaddition for the Surface Modification of Colloidal ... catalyzed azide-alkyne cycloaddition. (CuAAC) (i.e., "click" transformation) to produce fluoroprobes with a large Stokes shift ...
... modification of RNA with diverse molecules through the functionality transfer reaction and the copper-catalyzed azide-alkyne ... modification of RNA with diverse molecules through the functionality transfer reaction and the copper-catalyzed azide-alkyne ... modification of RNA with diverse molecules through the functionality transfer reaction and the copper-catalyzed azide-alkyne ... modification of RNA with diverse molecules through the functionality transfer reaction and the copper-catalyzed azide-alkyne ...
Modular Medical Imaging Agents Based on Azide-Alkyne Huisgen Cycloadditions: Synthesis and Pre-Clinical Evaluation of(18)F- ... Corrigendum: Modular Medical Imaging Agents Based on Azide-Alkyne Huisgen Cycloadditions: Synthesis and Pre-Clinical Evaluation ...
title = "Ruthenium-catalyzed aerobic oxidative cyclization of aromatic and heteroaromatic nitriles with alkynes: A new route to ... Ruthenium-catalyzed aerobic oxidative cyclization of aromatic and heteroaromatic nitriles with alkynes: A new route to ... Ruthenium-catalyzed aerobic oxidative cyclization of aromatic and heteroaromatic nitriles with alkynes : A new route to ... Ruthenium-catalyzed aerobic oxidative cyclization of aromatic and heteroaromatic nitriles with alkynes : A new route to ...
Markovnikovs Rule and Addn of ...
... and coordination reactions show that alkynes (RCCR) attain 1,2‐dicarbene nature during CCR angle ... ...
Halogenation of Alkynes. Description: Treatment of alkynes with one equivalent of a halogen (Cl2, Br2, I2) results in an ...
Homework Assignment Help is most useful online help portal for the students that providing all Online Alkynes and Alcohols ... Online Alkynes and Alcohols Chemistry Assignment Help. Alkynes include the class of organic compounds when at least one or more ... Uses of Alkyne. *Acetylene is used in the form of oxy-acetylene flame in welding and cutting tools . ... Methods of Preparation of Alkynes. Industrial method : It is prepared by the hydrolysis of calcium carbide ...
Video explaining Alkenes and Alkynes for Chemistry. This is one of many videos provided by Clutch Prep to prepare you to ... Under a Hydrohalogenation reaction an alkene or alkyne reacts with HCl or HBr to add a hydrogen and halogen to the pi bond. ... Under Hydrogenation an alkene or alkyne reacts with hydrogen gas (H2) over a metal catalyst in order to remove pi bonds. ... Here were going to say that alkenes and alkynes undergo addition reactions, so were adding to them, in which elements add ...
The orange-fluorescent Cy®3 Alkyne can be reacted with azides via a copper-catalysed click reaction (CuAAC). Cy®3 is a water- ... This sulfonated dye is also known as sulfo-Cyanine3 Alkyne. Cy® Dye is a trademark of GE Healthcare. ... The orange-fluorescent Cy®3 Alkyne can be reacted with azides via a copper-catalysed click reaction (CuAAC). Cy®3 is a water- ... This sulfonated dye is also known as sulfo-Cyanine3 Alkyne. Cy® Dye is a trademark of GE Healthcare. ...
The click reaction involves a copper-catalyzed triazole formation from an azide and an alkyne. The azide and alkyne moieties ... The Cy3 alkyne is reactive with azide via a copper-catalyzed click reaction that allows the subsequent visualization by ...
  • How will you distinguish between alkanes, alkenes and alkynes? (doubtnut.com)
  • The presence of pi bonds in both alkenes and alkynes allows them to undergo Addition Reactions . (clutchprep.com)
  • Here we're going to say that alkenes and alkynes undergo addition reactions, so we're adding to them, in which elements add across their pi bonds to create new sigma bonds. (clutchprep.com)
  • Alkenes and alkynes can be transformed into almost any other functional group you can name! (leslutinsduphoenix.com)
  • We will review their nomenclature, and also learn about the vast possibility of reactions using alkenes and alkynes as starting materials. (leslutinsduphoenix.com)
  • You can treat alkenes and alkynes as functional groups. (rsc.org)
  • This work represents our initial effort in identifying azide/alkyne pairs for optimal reactivity in copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions. (mdpi.com)
  • The [3+2] cycloaddition of CF 3 CHN 2 , generated in situ, with electron-deficient alkenes/alkynes affords CF 3 -substituted pyrazolines/pyrazoles in quantitative yields. (enamine.net)
  • In the first strategy, thermal azide-alkyne Huisgen cycloaddition was utilized to attach electron-poor acetylenediamides using a branched glutamic acid linker to azidized PVC, incorporating four plasticizing moieties per attachment point. (escholarship.org)
  • A versatile route for the synthesis of highly functionalized, polyanionic macromolecules based on dendritic polyglycerol was applied by means of the Huisgen-Sharpless-Meldal 1,3-dipolar cycloaddition ("click-reaction") of polyglycerolazide precursors and alkyne-functionalized anions such as sulfonates, carboxylates, phosphonates, and bisphosphonates. (fu-berlin.de)
  • As an alkyne , acetylene is bonded together in a triple bond. (hindlish.com)
  • Under ambient conditions, [email protected] showed remarkable adsorption of alkynes and efficient separations of acetylene/ethylene, propyne/propylene, and butyne/1,3-butadiene mixtures, with unprecedented dynamic separation selectivities of 100, 92, and 83, respectively. (nankai.edu.cn)
  • Based on reductive ozonolysis reaction, how do you distinguish between an alkene and alkyne? (doubtnut.com)
  • Reduction of alkynes is a useful method for the stereoselective synthesis of disubstituted alkenes. (leslutinsduphoenix.com)
  • The homodimerisation of terminal alkynes is found to proceed with high gem selectivity when employing aliphatic alkynes, whereas the reaction resulted in high Z-selectivity with aromatic alkynes, showing that the selectivity is dependent on the nature of the alkyne used. (hacettepe.edu.tr)
  • Bifunctional 4-Arm PEG-Alkyne/NHS reagents have two functional groups Alkyne and NHS ester at specific ratios of 1:3, 2:2, 3:1. (creativepegworks.com)
  • Glaser‐like coupling of terminal alkynes by thermal activation is extensively used in on‐surface chemistry. (usc.es)
  • We used voltage pulses from the tip to trigger a Glaser‐like coupling between terminal alkyne carbons within a custom‐synthesized precursor molecule adsorbed on bilayer NaCl on Cu(111). (usc.es)
  • How will you distinguish between terminal alkyne and nonteminal alkyne. (doubtnut.com)
  • The carbanions generated by deprotonation of terminal alkynes are called acetylides. (hindlish.com)
  • Vinyl silyl can be made from terminal alkyne or other methods. (hindlish.com)
  • Because trialkylsilyl groups are very commonly used to protect the terminal C-H of an alkyne, pro- tiodesilylation back to the parent alkyne is an important transformation. (gelest.com)
  • The same ruthenium complex was also shown to catalyse carboxylic acid (acetic acid, trichloroacetic acid, trans-2-octenoic acid, 4-cyclooctenoic acid) addition to terminal alkynes. (hacettepe.edu.tr)
  • The reactions of enoic acids, showed a high selectivity towards carboxylic acid addition to the triple bond of terminal alkynes, rather than triple bond addition to the double bond of the enoic acids. (hacettepe.edu.tr)
  • To evaluate the results obtained from the carboxylic acid addition reaction of terminal alkynes, the homodimerisation of terminal alkynes (phenylacetylene, 1-octyne, 1-heptyne) was also studied. (hacettepe.edu.tr)
  • The orange-fluorescent Cy®3 Alkyne can be reacted with azides via a copper-catalysed click reaction (CuAAC). (dcbiosci.com)
  • AZDye™ 546 Alkyne reacts with azides via a copper-catalyzed click reaction (CuAAC) to form a stable triazole linker. (clickchemistrytools.com)
  • PPh 3 AuCl/AgPF 6 -catalyzed hydroacyloxylation of alkynes with carboxylic acids affords the Markonikov addition products, whereas PPh 3 AuCl/AgOTf catalyst gives the more stable isomerized products via the Markonikov products. (organic-chemistry.org)
  • Copper-catalyzed fluoroalkylation of alkynes and alkynyl carboxylic acids has been achieved with high functional-group tolerance and excellent regio- and stereoselectivities. (researcher-app.com)
  • The click reaction involves a copper-catalyzed triazole formation from an azide and an alkyne. (abpbio.com)
  • The Cy3 alkyne is reactive with azide via a copper-catalyzed click reaction that allows the subsequent visualization by fluorescence spectroscopy. (abpbio.com)
  • We report on a novel reaction protocol for the coupling of arenes with alkynes (the Fujiwara reaction), yielding products of formal trans-hydroarylation of the triple bond. (unipd.it)
  • We discuss the applicability of this reaction protocol, which appears at present quite general with respect to the alkyne, albeit limited to electron-rich arenes. (unipd.it)
  • We report here on a chromium-catalyzed addition reaction of an arylmagnesium bromide to an unactivated internal alkyne to afford an ortho-alkenylarylmagnesium bromide. (elsevier.com)
  • This reaction likely proceeds via the insertion of an alkyne into an arylchromium species, alkenyl-to-aryl 1,4-chromium migration, and transmetalation between the resulting arylchromium species and the starting aryl Grignard reagent. (elsevier.com)
  • AZDye™ 546 Alkyne is a bright, orange-fluorescent alkyne-activated probe routinely used for imaging of low abundance azide-containing biomolecules. (clickchemistrytools.com)
  • Reddy, MC, Manikandan, R & Jeganmohan, M 2013, ' Ruthenium-catalyzed aerobic oxidative cyclization of aromatic and heteroaromatic nitriles with alkynes: A new route to isoquinolones ', Chemical Communications , vol. 49, no. 54, pp. 6060-6062. (bgu.ac.il)
  • In the current work, two types of alkynes are shown to undergo rapid CuAAC reactions under both copper(II)- (via an induction period) and copper(I)-catalyzed conditions. (mdpi.com)
  • Angles for nucleophilic attack on alkynes were reviewed and redefined recently. (hindlish.com)
  • The cobalt alkyne complex [(prop-2-ynyl)-2-acetoxybenzoate]dicobalthexacarbonyl (Co-ASS) is an auspicious lead, which exhibits its anticancer activity mainly by inhibition of both cyclooxygenases (COX-1 and COX-2). (rsc.org)
  • 3. Alkynes are sparingly soluble in polar solvents such as water but are readily soluble in organic solvents such as benzene, ether, acetone, etc. (preservearticles.com)
  • Alkynes include the class of organic compounds when at least one or more carbon-carbon triple bond is present. (homeworkassignmenthelp.com)
  • Tobisu, M , Nakai, H & Chatani, N 2009, ' Platinum and ruthenium chloride-catalyzed cycloisomerization of 1-alkyl-2-ethynylbenzenes: Interception of π-activated alkynes with a benzylic C-H bond ', Journal of Organic Chemistry , vol. 74, no. 15, pp. 5471-5475. (elsevier.com)
  • Tide Fluor™ 3 alkyne [TF3 alkyne] is a strong fluorescent dye used for labeling peptides and nucleotides. (scbt.com)
  • N-myristoylated proteins from VACV and the host were metabolically labelled with myristic acid alkyne during infection using quantitative chemical proteomics. (cdc.gov)
  • The first type of the alkynes bears relatively acidic ethynyl C-H bonds, while the second type contains an N -(triazolylmethyl)propargylic moiety that produces a self-accelerating effect. (mdpi.com)
  • The alkyne and NHS ester functionality are quantitated using spectroscopic techniques and colorimetric assays. (creativepegworks.com)
  • 2016) Biocompatible Azide-Alkyne "Click" Reactions for Surface Decoration of Glyco-Engineered Cells. (jenabioscience.com)
  • Lower alkynes upto four carbon atoms are gases, those containing five to thirteen carbon atoms are liquids while higher alkynes are solids. (preservearticles.com)
  • Hidrocarburos con al menos un triple enlace en la porción lineal, con fórmula general Cn-H2n-2. (bvsalud.org)
  • The efficient removal of alkyne impurities for the production of polymer-grade lower olefins remains an important and challenging goal for many industries. (nankai.edu.cn)