Alkynes
Cyclization
Rhodium
Click Chemistry
Organic chemistry methodology that mimics the modular nature of various biosynthetic processes. It uses highly reliable and selective reactions designed to "click" i.e., rapidly join small modular units together in high yield, without offensive byproducts. In combination with COMBINATORIAL CHEMISTRY TECHNIQUES, it is used for the synthesis of new compounds and combinatorial libraries.
Alkenes
Stereoisomerism
Molecular Structure
Catalysis
Palladium
Cycloparaffins
Alicyclic hydrocarbons in which three or more of the carbon atoms in each molecule are united in a ring structure and each of the ring carbon atoms is joined to two hydrogen atoms or alkyl groups. The simplest members are cyclopropane (C3H6), cyclobutane (C4H8), cyclohexane (C6H12), and derivatives of these such as methylcyclohexane (C6H11CH3). (From Sax, et al., Hawley's Condensed Chemical Dictionary, 11th ed)
Ruthenium
Cycloaddition Reaction
Amination
Indolizidines
Organometallic Compounds
Silanes
Organogold Compounds
Combinatorial Chemistry Techniques
Heterocyclic Compounds
Smoothing of the thermal stability of DNA duplexes by using modified nucleosides and chaotropic agents. (1/688)
The effect of alkyltrimethylammonium ions on the thermostability of natural and modified DNA duplexes has been investigated. We have shown that the use of tetramethylammonium ions TMA+along with the chemical modification of duplexes allow the fine adjustment of T m and the possibility of obtaining several duplex systems with varied isostabilizedtemperatures, some of which show greater stability than those of natural DNA. This approach could be very useful for DNA sequencing by hybridization. (+info)Inhibition of glutathione synthesis with propargylglycine enhances N-acetylmethionine protection and methylation in bromobenzene-treated Syrian hamsters. (2/688)
The finding that liver necrosis caused by the environmental glutathione (GSH)-depleting chemical, bromobenzene (BB) is associated with marked impairment in O- and S-methylation of BB metabolites in Syrian hamsters raises questions concerning the role of methyl deficiency in BB toxicity. N-Acetylmethionine (NAM) has proven to be an effective antidote against BB toxicity when given after liver GSH has been depleted extensively. The mechanism of protection by NAM may occur via a replacement of methyl donor and/or via an increase of GSH synthesis. If replacement of the methyl donor is an important process, then blocking the resynthesis of GSH in the methyl-repleted hamsters should not decrease NAM protection. This hypothesis was examined in this study. Propargylglycine (PPG), an irreversible inhibitor of cystathionase, was used to inhibit the utilization of NAM for GSH resynthesis. Two groups of hamsters were pretreated with an intraperitoneal (ip) dose of PPG (30 mg/kg) or saline 24 h before BB administration (800 mg/kg, ip). At 5 h after BB treatment, an ip dose of NAM (1200 mg/kg) was given. Light microscopic examinations of liver sections obtained 24 h after BB treatment indicated that NAM provided better protection (P < 0.05) in the PPG + BB + NAM group than in the BB + NAM group. Liver GSH content, however, was lower in the PPG + BB + NAM group than in the BB + NAM group. The Syrian hamster has a limited capability to N-deacetylated NAM. The substitution of NAM with methionine (Met; 450 mg/kg) resulted in a higher level of GSH in the BB + Met group than in the BB + NAM group (P < 0.05). The enhanced protection by PPG in the PPG + BB + NAM group was accompanied by higher (P < 0.05) urinary excretions of specificO- and S-methylated bromothiocatechols than in the BB + NAM group. The results suggest that NAM protection occurs primarily via a replacement of the methyl donor and that methyl deficiency occurring in response to GSH repletion plays a potential role in BB toxicity. (+info)Inhibition of gene expression by anti-sense C-5 propyne oligonucleotides detected by a reporter enzyme. (3/688)
Using a reporter plasmid containing the luciferase gene under the control of the insulin-like growth factor 1 (IGF-1) promoter region [including its 5' untranslated region (UTR)], we demonstrate that a 17-mer oligophosphorothioate containing C-5 propyne pyrimidines is able to inhibit luciferase gene expression in the nanomolar concentration range when the anti-sense oligonucleotide is targeted either to a coding sequence in the luciferase gene or to the 5' UTR of the gene for IGF-1. Inhibition was obtained independently of whether the plasmid and the anti-sense oligonucleotide were co-transfected or transfected separately into hepatocarcinoma cells. However, the efficiency of inhibition by the anti-sense oligonucleotides was 10-fold greater in the first case. The unmodified oligophosphorothioate targeted to the 5' UTR of IGF-1 did not inhibit luciferase gene expression at a 100-fold higher concentration unless its length was increased from 17 to 21 nt, in which case an inhibition of gene expression was obtained and an IC50 of 200 nM was observed. (+info)Elevated expression of liver gamma-cystathionase is required for the maintenance of lactation in rats. (4/688)
Liver gamma-cystathionase activity increases in rats during lactation; its inhibition due to propargylglycine is followed by a significant decrease in lactation. This is reversible by N-acetylcysteine administration. To study the role of liver gamma-cystathionase and the intertissue flux of glutathione during lactation, we used lactating and virgin rats fed liquid diets. Virgin rats were divided into two groups as follows: one group was fed daily a diet containing the same amount of protein that was consumed the previous day by lactating rats (high protein diet-fed rats); the other virgin group was fed the normal liquid diet (control). The expression and activity of liver gamma-cystathionase were significantly greater in lactating rats and in high protein diet-fed virgin rats compared with control rats. The total glutathione [reduced glutathione (GSH) + oxidized glutathione (GSSG)] released per gram of liver did not differ in lactating rats or in high protein diet-fed rats, but it was significantly higher in these two groups than in control virgin rats. Liver size and the GSH + GSSG released by total liver were significantly higher in lactating rats than in high protein diet-fed virgin rats, and this difference was similar to the amount of glutathione taken up by the mammary gland (454.2 +/- 36.0 nmol/min). The uptake of total glutathione by the lactating mammary gland was much higher than the uptakes of free L-cysteine and L-cystine, which were negligible. These data suggest that the intertissue flux of glutathione is an important mechanism of L-cysteine delivery to the lactating mammary gland, which lacks gamma-cystathionase activity. This emphasizes the physiologic importance of the increased expression and activity of liver gamma-cystathionase during lactation. (+info)Guest exchange in an encapsulation complex: a supramolecular substitution reaction. (5/688)
Encapsulation complexes are reversibly formed assemblies in which small molecule guests are completely surrounded by large molecule hosts. The assemblies are held together by weak intermolecular forces and are dynamic: they form and dissipate on time scales ranging from milliseconds to days-long enough for many interactions, even reactions, to take place within them. Little information is available on the exchange process, how guests get in and out of these complexes. Here we report that these events can be slow enough for conventional kinetic studies, and reactive intermediates can be detected. Guest exchange has much in common with familiar chemical substitution reactions, but differs in some respects: no covalent bonds are made or broken, the substrate is an assembly rather than a single molecule, and at least four molecules are involved in multiple rate-determining steps. (+info)Effects of a lipoxygenase inhibitor, panaxynol, on vascular contraction induced by angiotensin II. (6/688)
We investigated whether a lipoxygenase inhibitor, panaxynol, affected the vascular contraction induced by angiotensin (Ang) II and the mean arterial pressure in spontaneously hypertensive rats (SHR). Panaxynol suppressed dose-dependently the contractile responses induced by 30 nM Ang II in isolated intact and endothelial cell-denuded aorta in the hamster. IC50 values in the intact and endothelial cell-denuded aorta were 23 and 20 microM, respectively. In SHR, the mean arterial pressure after injection of 30 and 60 mg/kg panaxynol was reduced, and the maximum hypotensive values were 23 and 48 mmHg, respectively. Thus, lipoxygenase products may affect the renin-angiotensin system. (+info)Similarity and dissimilarity in mode and mechanism of action between YT-146, a selective adenosine receptor A2 agonist, and adenosine in isolated canine hearts. (7/688)
To elucidate the differences in mode and mechanism of action between YT-146, a highly selective adenosine A2 receptor agonist, and adenosine, we compared their effects on coronary circulation and myocardium and modifications of these effects by glibenclamide, a blocker of ATP-sensitive potassium (K) channels, in three kinds of isolated, blood-perfused canine heart preparations. YT-146 and adenosine were injected i.a. In all preparations both YT-146 and adenosine increased coronary blood flow and in this respect YT-146 was about 5 times as potent as adenosine. The increase in blood flow caused by adenosine was transient, whereas that produced by YT-146 was biphasic; the transient increase was followed by a sustained one. In isolated, blood-perfused sinoatrial (SA) node preparations, YT-146 failed to affect sinus rate, whereas adenosine reduced sinus rate by about 38% at its maximum effect. In isolated, blood-perfused atrioventricular (AV) node preparations, when injected into the artery supplying the AV node, YT-146 exerted no effect on AV conduction time, whereas adenosine prolonged AV conduction time by about 17% at the maximum effect. In isolated, blood-perfused papillary muscle preparations, the force of contraction was affected by neither YT-146 nor adenosine. In the same preparations the effect of YT-146 in increasing coronary blood flow was antagonized by glibenclamide in such a manner that the maximum increase was suppressed, but that of adenosine was not. Reactive hyperemia induced by ischemia for 30 seconds was not affected by glibenclamide. These results suggest that although both YT-146 and adenosine produce an increase in coronary blood flow via adenosine A2 receptors, the opening of ATP- or glibenclamide-sensitive K channels is involved in the action of the former, but scarcely in the action of the latter. The opening of ATP- or glibenclamide-sensitive K-channels is less likely involved in reactive hyperemia. (+info)NAD(+)-dependent (S)-specific secondary alcohol dehydrogenase involved in stereoinversion of 3-pentyn-2-ol catalyzed by Nocardia fusca AKU 2123. (8/688)
An NAD(+)-dependent alcohol dehydrogenase was purified to homogeneity from Nocardia fusca AKU 2123. The enzyme catalyzed (S)-specific oxidation of 3-pentyn-2-ol (PYOH), i.e., part of the stereoinversion reaction for the production of (R)-PYOH, which is a valuable chiral building block for pharmaceuticals, from the racemate. The enzyme used a broad variety of secondary alcohols including alkyl alcohols, alkenyl alcohols, acetylenic alcohols, and aromatic alcohols as substrates. The oxidation was (S)-isomer specific in every case. The K(m) and Vmax for (S)-PYOH and (S)-2-hexanol oxidation were 1.6 mM and 53 mumol/min/mg, and 0.33 mM and 130 mumol/min/mg, respectively. The enzyme also catalyzed stereoselective reduction of carbonyl compounds. (S)-2-Hexanol and ethyl (R)-4-chloro-3-hydroxybutanoate in high optical purity were produced from 2-hexanone and ethyl 4-chloro-3-oxobutanoate by the purified enzyme, respectively. The K(m) and Vmax for 2-hexanone reduction were 2.5 mM and 260 mumol/min/mg. The enzyme has a relative molecular mass of 150,000 and consists of four identical subunits. The NH2-terminal amino acid sequence of the enzyme shows similarity with those of the carbonyl reductase from Rhodococcus erythropolis and phenylacetaldehyde reductase from Corynebacterium sp. (+info)
organic chemistry - Correct definition of terminal alkynes? - Chemistry Stack Exchange
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the type of hybridization in alkynes is
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Sonogashira coupling
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Alkyne
Alkynes form complexes with transition metals. Such complexes occur also in metal catalyzed reactions of alkynes such as alkyne ... Look up alkyne in Wiktionary, the free dictionary. Wikiquote has quotations related to Alkyne. -yne cycloalkyne Alkyne. ... Cycloaddition processes involving alkynes are often catalyzed by metals, e.g. enyne metathesis and alkyne metathesis, which ... Electrophilic alkynes are especially effective dienophiles. The "cycloadduct" derived from the addition of alkynes to 2-pyrone ...
Alkyne trimerisation
Alkyne trimerization is of no practical value, although the reaction was highly influential. The cotrimerization of alkynes and ... In organic chemistry, an alkyne trimerisation is a [2+2+2] cycloaddition reaction in which three alkyne units (C≡C) react to ... In terms of mechanism, the reactions begin with the formation of metal-alkyne complexes. The combination of two alkynes within ... Many variations have been developed, including cyclisation of mixtures of alkynes and alkenes as well as alkynes and nitriles. ...
Alkyne metathesis
... can be used in ring-closing operations and RCAM stands for ring closing alkyne metathesis. The olfactory ... Alkyne metathesis is an organic reaction that entails the redistribution of alkyne chemical bonds. The reaction requires metal ... Catalysts for alkyne metathesis "canopy catalysts" Air stable low-valent d2 rhenium alkylidyne various Schrock-based alkyne ... Ritter, S. (March 26, 2007). "Nitrile-Alkyne Cross-Metathesis". Chemical & Engineering News. Alkyne Metathesis in Organic ...
Alkyne zipper reaction
The alkyne zipper reaction is an organic reaction that involves isomerization of a non terminal alkyne into a terminal alkyne. ... essentially moving the alkyne along the alkane chain until a terminal alkyne is achieved. Once a terminal alkyne is achieved, ... 8, p. 146 "Alkyne Zipper Reaction". SynArchive. 2017. Archived from the original on 2011. Retrieved December 19, 2017. ( ... The conversion provides a useful approach for remote functionalization in long-chain alkynes. The reaction requires a strong ...
Transition metal alkyne complex
... es are often formed by the displacement of labile ligands by the alkyne. For example, a variety ... This kind of bonding was first implicated in complexes of the type W(CO)(R2C2)3. Because alkynes have two π bonds, alkynes can ... Metal alkyne complexes are intermediates in the semihydrogenation of alkynes to alkenes: C2R2 + H2 → cis-C2R2H2 This ... In organometallic chemistry, a transition metal alkyne complex is a coordination compound containing one or more alkyne ligands ...
Azide-alkyne Huisgen cycloaddition
The azide-alkyne Huisgen cycloaddition is a 1,3-dipolar cycloaddition between an azide and a terminal or internal alkyne to ... Unlike CuAAC in which only terminal alkynes reacted, in RuAAC both terminal and internal alkynes can participate in the ... While the copper(I)-catalyzed variant gives rise to a triazole from a terminal alkyne and an azide, formally it is not a 1,3- ... The copper (I) species generated in situ forms a pi complex with the triple bond of a terminal alkyne. In the presence of a ...
Marcey Waters
"Mechanistic Studies on the Reaction of Fischer Carbene Complex with Alkynes: Does the Alkyne Insertion Intermediate Form ... and alkynes. Walters graduated from Chicago in 1997 with a PhD in chemistry. She was an NIH postdoctoral fellow in Prof. Ronald ...
Unsaturated hydrocarbon
"Hydration of Alkynes". Chem LibreTexts. May 2, 2019. Retrieved May 6, 2019. "Reactions of Alkynes - Addition of HX and X2". ... Alkynes, under metal catalysts, for example cobalt, can also go under cycloaddition reaction called alkyne trimerization. Three ... The DCD model can also describe the alkyne ligand structure. Metal complex can also be intermediate of trimerization of alkynes ... The hydrohalogenation of alkyne is much slower than the alkene. The reaction equation of HBr addition to ethene is: H2C=CH2 + ...
Cis-trans isomerism
Ouellette, Robert J.; Rawn, J. David (2015). "Alkenes and Alkynes". Principles of Organic Chemistry. pp. 95-132. doi:10.1016/ ... being the only isomer that can reduce alkenes and alkynes to alkanes, but for a different reason: the trans isomer cannot line ...
Thiol-yne reaction
The thiol-yne reaction (also known as alkyne hydrothiolation) is an organic reaction between a thiol and an alkyne. The ... Diphenyl disulfide reacts with alkynes to a 1,2-bis(phenylthio)ethylene. Reported alkynes are ynamides. A photoredox thiol-yne ... Yadav, J. S.; Reddy, B. V. Subba; Raju, A.; Ravindar, K.; Baishya, Gakul (2007). "Hydrothiolation of Unactivated Alkynes ... Weiss, Charles J.; Wobser, Stephen D.; Marks, Tobin J. (2009). "Organoactinide-Mediated Hydrothiolation of Terminal Alkynes ...
Ethynyl
Also sometimes designed as ethinyl in compounds (ethinylestradiol, ethisterone (ethinyltestosterone)). See main page alkynes. ...
Favorskii reaction
This reaction is used to protect alkynes: the alkyne is either converted with acetone to a 2-hydroxyprop-2-yl-alkyne or a ... A metal acetylide is formed in situ when an alkyne is treated with a strong bases such as a hydroxide or an alkoxide: HC≡CH + ... 3.0.CO;2-R. Wuts, Peter G. M.; Greene, Theodora W. (2007). "Chapter 8. Protection for the Alkynes". Greene's Protective Groups ... The Favorskii reaction is an organic chemistry reaction between an alkyne and a carbonyl group, under basic conditions. The ...
Ketone
By hydration of alkynes. Such processes occur via enols and require the presence of an acid and mercury(II) sulfate (HgSO4). ... This equilibrium allows ketones to be prepared via the hydration of alkynes. C−H bonds adjacent to the carbonyl in ketones are ... Ketones containing alkene and alkyne units are often called unsaturated ketones. The most widely used member of this class of ... This reaction always produces a ketone, even with a terminal alkyne, the only exception being the hydration of acetylene, which ...
Glossary of engineering: A-L
Alkyne Is an unsaturated hydrocarbon containing at least one carbon-carbon triple bond. The simplest acyclic alkynes with only ... ISBN 978-1-4058-5345-3. Alkyne. Encyclopædia Britannica Callister, W. D. "Materials Science and Engineering: An Introduction" ...
Glossary of civil engineering
alkyne In organic chemistry, an unsaturated hydrocarbon containing at least one carbon-carbon triple bond. alloy A combination ... ISBN 978-1-4058-5345-3. Alkyne. Encyclopædia Britannica Callister, W. D. "Materials Science and Engineering: An Introduction" ...
Organozirconium chemistry
Substrates for hydrozirconation are alkenes and alkynes. Terminal alkynes give vinyl complexes. Secondary reactions are ...
Carbometalation
Trimethyl Silyl (TMS) protected alkynes, trimethyl germanium alkynes, and terminal alkynes can produce anti-carboalumination ... This zirconium cation can coordinate an alkene or alkyne where migratory insertion of a methyl then takes place. The resultant ... Carbometalations can be performed on alkynes and alkenes to form products with high geometric purity or enantioselectivity, ... Novel syntheses of .alpha.,.beta.-unsaturated cyclopentenones via allylzincation of alkynes". Journal of the American Chemical ...
Organogold chemistry
In 1991, Utimoto reacted gold(III) (NaAuCl4) with alkynes and water. Teles identified a major drawback of this method as Au(III ... Norman, R. O. C.; Parr, W. J. E.; Thomas, C. B. (1976). "The reactions of alkynes, cyclopropanes, and benzene derivatives with ... Cationic gold(I) forms π-complexes with alkene or alkyne bonds, following the Dewar-Chatt-Duncanson model. Gold is certainly ... For instance, Hashmi reported an AuCl3-catalyzed alkyne / furan Diels-Alder reaction - a type of cycloaddition that does not ...
Organophosphine
Similar reactions occur involving alkynes. Base is not required for electron-deficient alkenes (e.g., derivatives of ... "Nucleophilic and free-radical additions of phosphines and phosphine chalcogenides to alkenes and alkynes". Arkivoc. v (5): 12- ... acrylonitrile) and alkynes. Secondary (2°) phosphines, with the formula R2PH, are prepared analogously to the primary ...
Seyferth-Gilbert homologation
The generation of nitrogen gas gives a vinyl carbene G, which via a 1,2-migration forms the desired alkyne H. The dimethyl ( ... A facile synthesis of alkynes". J. Org. Chem. 47 (10): 1837-1845. doi:10.1021/jo00349a007. D. G. Brown; E. J. Velthuisen; J. R ... S. Müller; B. Liepold; G. Roth & H. J. Bestmann (1996). "An Improved One-pot Procedure for the Synthesis of Alkynes from ... Reaction of Bestmann's reagent with aldehydes gives terminal alkynes often in very high yield and fewer steps than the Corey- ...
Hydroamination
The four main categories are (1) nucleophilic attack on an alkene alkyne, or allyl ligand and (2) insertion of the alkene into ... Pohlki, F.; Doye, S. (2003). "The catalytic hydroamination of alkynes". Chem. Soc. Rev. 32: 104-114. doi:10.1039/b200386b. PMID ... Alonso, F.; Beletskaya, I.P.; Yus, M. (2004). "Transition-Metal-Catalyzed Addition of Heteroatom−Hydrogen Bonds to Alkynes". ... The unsaturated substrates that have been investigated include alkenes, dienes, alkynes, and allenes. For intramolecular ...
Diphosphorus tetrafluoride
Other kinds of alkynes produced polymers with this treatment. With alkenes, similarly bis(difluorophosphino) is added across ... Under ultraviolet light diphosphorus tetrafluoride reacts with alkynes connected to trifluoromethyl groups to add ... "Photoreactions of tetrafluorodiphosphine with alkynes". Journal of Fluorine Chemistry. 40 (1): 41-49. doi:10.1016/S0022-1139(00 ...
Chloroplatinic acid
Lewis, L. N.; Sy, K. G.; Bryant, G. L.; Donahue, P. E. (1991). "Platinum-catalyzed hydrosilylation of alkynes". Organometallics ...
Sonogashira coupling
Various aromatic alkynes can be employed to yield desired disubstituted products with satisfactorily yields. Aliphatic alkynes ... It is suggested that the presence of a base results in the formation of a π-alkyne complex E. This increases the acidity of the ... It employs a palladium catalyst as well as copper co-catalyst to form a carbon-carbon bond between a terminal alkyne and an ... Copper(I) salts, such as CuI, react with the terminal alkyne and produce a copper(I) acetylide, which acts as an activated ...
Hydrostannylation
The typical Pd-based catalyst is tetrakis(triphenylphosphine)palladium(0). The typical unsaturated substrates are alkynes. The ...
Zinc triflate
R. J. Rahaim & J. T. Shaw (2008). "Zinc-Catalyzed Silylation of Terminal Alkynes". J. Org. Chem. 73 (7): 2912-2915. doi:10.1021 ... "Silylation of 1-alkynes with chlorosilanes promoted by Zn(OTf)2: an efficient way to the preparation of alkynylsilanes". ...
1-Decyne
It is a terminal alkyne. A colorless liquid, 1-decyne is used as a model substrate when evaluating methodology in organic ... Ishiyama, Tatsuo; Matsuda, Nobuo; Miyaura, Norio; Suzuki, Akira (1993). "Platinum(0)-Catalyzed Diboration of Alkynes". Journal ... of Azides and Terminal Alkynes". Angewandte Chemie International Edition. 41 (14): 2596-2599. doi:10.1002/1521-3773(20020715)41 ...
Borole
The reaction with the electron-poor alkyne (C6F5)CC(C6F5) required rather harsh reaction conditions (110 °C, 7 days) and the ... In that study, 2 was reacted with three differently substituted alkynes that greatly differed in their electronic properties, ... towards alkynes in great detail. Of particular relevance was the question of whether the enhanced Lewis acidity of 2 compared 1 ... The potent Lewis acidity of 12 revealed a novel reaction pathway whereby the alkyne first adds to the borole nucleophilically, ...
Iminoborane
Like alkynes, iminoboranes bind transition metals. Paetzold, Peter; Plotho, Christoph Von; Schmid, Günter; Boese, Roland; ...
Bicyclononyne
September 2011). "Bioconjugation with strained alkenes and alkynes". Acc Chem Res. 44 (9): 805-15. doi:10.1021/ar200059z. PMID ...
Gold(I)-Catalyzed Addition of Carboxylic Acids to Alkynes
Molecules | Free Full-Text | Structural Determinants of Alkyne Reactivity in Copper-Catalyzed Azide-Alkyne Cycloadditions
This work represents our initial effort in identifying azide/alkyne pairs for optimal reactivity in copper-catalyzed azide- ... alkyne cycloaddition (CuAAC) reactions. In previous works, we have identified chelating azides, in particular 2-picolyl azide, ... Choice of Alkynes. The tested alkynes are separated in three categories: (a) electron-withdrawing group-bearing alkynes (Figure ... Alkynes 20 and 21 were reexamined with the rest of alkynes at the original substrate concentrations (10 mM each for alkyne and ...
Intramolecular Coupling of Terminal Alkynes by Atom Manipulation
... Author:. Albrecht, Florian. Rey Vieites, Dulce María. Fatayer ... We used voltage pulses from the tip to trigger a Glaser‐like coupling between terminal alkyne carbons within a custom‐ ... Glaser‐like coupling of terminal alkynes by thermal activation is extensively used in on‐surface chemistry. Here we demonstrate ...
Tide Fluor™ 3 alkyne [TF3 alkyne] | SCBT - Santa Cruz Biotechnology
Sulfo-Cy5-Alkyne, Alkyne-containing Fluorescent Dyes - Jena Bioscience
Click Reagents by Chemistry Alkyne Reagents Fluorescent Dyes ... Sulfo-Cy5-Alkyne. Abs/Em = 647/663 nm. bis(Triethylammonium) ... You are here: Click Chemistry , Click Reagents by Chemistry , Alkyne Reagents , Fluorescent Dyes , Sulfo-Cy5-Alkyne ... Gutman et al. (2016) Biocompatible Azide-Alkyne "Click" Reactions for Surface Decoration of Glyco-Engineered Cells. Chembiochem ...
Fluorination as tool to improve bioanalytical sensitivity and COX-2-selective antitumor activity of cobalt alkyne complexes -...
The cobalt alkyne complex [(prop-2-ynyl)-2-acetoxybenzoate]dicobalthexacarbonyl (Co-ASS) is an auspicious lead, which exhibits ... Fluorination as tool to improve bioanalytical sensitivity and COX-2-selective antitumor activity of cobalt alkyne complexes† ... The cobalt alkyne complex [(prop-2-ynyl)-2-acetoxybenzoate]dicobalthexacarbonyl (Co-ASS) is an auspicious lead, which exhibits ... Fluorination as tool to improve bioanalytical sensitivity and COX-2-selective antitumor activity of cobalt alkyne complexes D. ...
What are the physical properties of Alkynes?
Lower alkynes upto four carbon atoms are gases, those containing five to thirteen carbon atoms are liquids while higher alkynes ... Alkynes have physical properties similar to alkanes and alkenes. ... 3. Alkynes are sparingly soluble in polar solvents such as ... Lower alkynes upto four carbon atoms are gases, those containing five to thirteen carbon atoms are liquids while higher alkynes ... 1. Alkynes have physical properties similar to alkanes and alkenes. ...
Palladium nanoparticle catalysts in ionic liquids: synthesis, characterisation and selective partial hydrogenation of alkynes...
Reactions of the mixed-metal alkyne-bridged complexes [(η<sup>5</sup>-C<sub>5</sub>H<sub>5</sub>)(OC)<sub>2</sub>M{μ-C <sub>2<...
Reactions of the mixed-metal alkyne-bridged complexes [(η5-C5H5)(OC)2M{μ-C 2(CO2Me)2}Co(CO)3] (M=Mo or W) with Ph2PCCtBu1. In: ... Reactions of the mixed-metal alkyne-bridged complexes [(η5-C5H5)(OC)2M{μ-C 2(CO2Me)2}Co(CO)3] (M=Mo or W) with Ph2PCCtBu1. / ... Reactions of the mixed-metal alkyne-bridged complexes [(η5-C5H5)(OC)2M{μ-C 2(CO2Me)2}Co(CO)3] (M=Mo or W) with Ph2PCCtBu1. ... Reactions of the mixed-metal alkyne-bridged complexes [(η5-C5H5)(OC)2M{μ-C 2(CO2Me)2}Co(CO)3] (M=Mo or W) with Ph2PCCtBu1. ...
The synthesis of heteroaromatic prostacyclin analogues via keto alkyne cyclisation
4-Arm PEG-Alkyne/NHS - Creative PEGWorks
Bifunctional 4-Arm PEG-Alkyne/NHS reagents have two functional groups Alkyne and NHS ester at specific ratios of 1:3, 2:2, 3:1 ... Bifunctional 4-Arm PEG-Alkyne/NHS reagents have two functional groups Alkyne and NHS ester at specific ratios of 1:3, 2:2, 3:1 ... The alkyne and NHS ester functionality are quantitated using spectroscopic techniques and colorimetric assays. The NHS ester is ...
One-Pot Synthesis of CF<sub>3</sub>-Substituted Pyrazolines/Pyrazoles from Electron-Deficient Alkenes/Alkynes and CF<sub>3</sub...
One-Pot Synthesis of CF3-Substituted Pyrazolines/Pyrazoles from Electron-Deficient Alkenes/Alkynes and CF3CHN2 Generated in ... One-Pot Synthesis of CF3-Substituted Pyrazolines/Pyrazoles from Electron-Deficient Alkenes/Alkynes and CF3CHN2 Generated in ... The [3+2] cycloaddition of CF3CHN2, generated in situ, with electron-deficient alkenes/alkynes affords CF3-substituted ...
Alkyne-PEG9-N3 | Biopharma PEG
Alkynes - Reagents for Click-Conjugation - PEGylation - DRUG DELIVERY - Products
Thank you very much for your interest in our products. All prices listed on our website are ex-works, Germany, and may attract customs duties when imported.. You may/will be contacted by the shipping company for additional documentation that may be required by the US Customs for clearance.. We offer you the convenience of buying though a local partner, Peptide Solutions LLC who can import the shipment as well as prepay the customs duties and brokerage on your behalf and provide the convenience of a domestic sale.. Continue to Iris Biotech GmbHSend request to US distributor ...
Copper-catalyzed fluoroalkylation of alkynes, and alkynyl & viny
Copper-catalyzed fluoroalkylation of alkynes and alkynyl carboxylic acids has been achieved with high functional-group ... Copper-catalyzed fluoroalkylation of alkynes, and alkynyl & vinyl carboxylic acids with fluoroalkyl halides. Jing-Jing Ma, Wen- ... Copper-catalyzed fluoroalkylation of alkynes and alkynyl carboxylic acids has been achieved with high functional-group ...
How will you distinguish between alkanes, alkenes and alkynes?
our alkenes alkynes are those which have at least one double bond at least one double bond have like it was a single point ... carbon atoms c2h -2 that is c2h means the general Formula for alkynes and it is also a type of unsaturated hydrocarbon hydro ... hydrocarbon and saturated a dose of the double bond and triple let us discuss alkine sunao water alkenes alkynes are those ... hi everyone lets take a questionnaire the question is how will you distinguish between alkanes alkenes and alkynes have to ...
Internal Plasticization of Poly(Vinyl Chloride) using Thermal Azide-Alkyne Huisgen Cycloaddition and Copper-Mediated Atom...
Whereas the azide-alkyne approach may be suffered from the potential danger in handling azides on large scale, the ATRP graft ... In the first strategy, thermal azide-alkyne Huisgen cycloaddition was utilized to attach electron-poor acetylenediamides using ... Internal Plasticization of Poly(Vinyl Chloride) using Thermal Azide-Alkyne Huisgen Cycloaddition and Copper-Mediated Atom ...
"Utilizing Copper(I) Catalyzed Azide-Alkyne Huisgen 1,3-Dipolar Cycload" by Parul Rungta
Rungta, Parul, "Utilizing Copper(I) Catalyzed Azide-Alkyne Huisgen 1,3-Dipolar Cycloaddition for the Surface Modification of ... Utilizing Copper(I) Catalyzed Azide-Alkyne Huisgen 1,3-Dipolar Cycloaddition for the Surface Modification of Colloidal ... catalyzed azide-alkyne cycloaddition. (CuAAC) (i.e., "click" transformation) to produce fluoroprobes with a large Stokes shift ...
Pin-point chemical modification of RNA with diverse molecules through the functionality transfer reaction and the copper...
... modification of RNA with diverse molecules through the functionality transfer reaction and the copper-catalyzed azide-alkyne ... modification of RNA with diverse molecules through the functionality transfer reaction and the copper-catalyzed azide-alkyne ... modification of RNA with diverse molecules through the functionality transfer reaction and the copper-catalyzed azide-alkyne ... modification of RNA with diverse molecules through the functionality transfer reaction and the copper-catalyzed azide-alkyne ...
Modular Medical Imaging Agents Based on Azide-Alkyne Huisgen Cycloadditions: Synthesis and Pre-Clinical Evaluation of(18)F...
Ruthenium-catalyzed aerobic oxidative cyclization of aromatic and heteroaromatic nitriles with alkynes: A new route to...
title = "Ruthenium-catalyzed aerobic oxidative cyclization of aromatic and heteroaromatic nitriles with alkynes: A new route to ... Ruthenium-catalyzed aerobic oxidative cyclization of aromatic and heteroaromatic nitriles with alkynes: A new route to ... Ruthenium-catalyzed aerobic oxidative cyclization of aromatic and heteroaromatic nitriles with alkynes : A new route to ... Ruthenium-catalyzed aerobic oxidative cyclization of aromatic and heteroaromatic nitriles with alkynes : A new route to ...
Browsing 2018 by Subject "alkynes"
Halogenation of Alkynes - Master Organic Chemistry
Online Alkynes and Alcohols Chemistry Assignment Help
Homework Assignment Help is most useful online help portal for the students that providing all Online Alkynes and Alcohols ... Online Alkynes and Alcohols Chemistry Assignment Help. Alkynes include the class of organic compounds when at least one or more ... Uses of Alkyne. *Acetylene is used in the form of oxy-acetylene flame in welding and cutting tools . ... Methods of Preparation of Alkynes. Industrial method : It is prepared by the hydrolysis of calcium carbide ...
Alkenes and Alkynes - Chemistry Video | Clutch Prep
Video explaining Alkenes and Alkynes for Chemistry. This is one of many videos provided by Clutch Prep to prepare you to ... Under a Hydrohalogenation reaction an alkene or alkyne reacts with HCl or HBr to add a hydrogen and halogen to the pi bond. ... Under Hydrogenation an alkene or alkyne reacts with hydrogen gas (H2) over a metal catalyst in order to remove pi bonds. ... Here were going to say that alkenes and alkynes undergo addition reactions, so were adding to them, in which elements add ...
Cy3-Alkyne - DC Biosciences
The orange-fluorescent Cy®3 Alkyne can be reacted with azides via a copper-catalysed click reaction (CuAAC). Cy®3 is a water- ... This sulfonated dye is also known as sulfo-Cyanine3 Alkyne. Cy® Dye is a trademark of GE Healthcare. ... The orange-fluorescent Cy®3 Alkyne can be reacted with azides via a copper-catalysed click reaction (CuAAC). Cy®3 is a water- ... This sulfonated dye is also known as sulfo-Cyanine3 Alkyne. Cy® Dye is a trademark of GE Healthcare. ...
Alkenes and alkynesAzide-alkyne cycloadditionCycloadditionAcetyleneAlkene and alkyneSynthesisAliphaticAlkanesReagentsTerminalAzides viaCarboxylic acidsReactionOrange-fluorescentHeteroaromaticCuAACNucleophilicCobaltSolubleOrganic compoundsChemistryFluorescentQuantitativeBondsFunctionalityClickHigherGeneralLower
Alkenes and alkynes6
- How will you distinguish between alkanes, alkenes and alkynes? (doubtnut.com)
- The presence of pi bonds in both alkenes and alkynes allows them to undergo Addition Reactions . (clutchprep.com)
- Here we're going to say that alkenes and alkynes undergo addition reactions, so we're adding to them, in which elements add across their pi bonds to create new sigma bonds. (clutchprep.com)
- Alkenes and alkynes can be transformed into almost any other functional group you can name! (leslutinsduphoenix.com)
- We will review their nomenclature, and also learn about the vast possibility of reactions using alkenes and alkynes as starting materials. (leslutinsduphoenix.com)
- You can treat alkenes and alkynes as functional groups. (rsc.org)
Azide-alkyne cycloaddition1
- This work represents our initial effort in identifying azide/alkyne pairs for optimal reactivity in copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions. (mdpi.com)
Cycloaddition3
- The [3+2] cycloaddition of CF 3 CHN 2 , generated in situ, with electron-deficient alkenes/alkynes affords CF 3 -substituted pyrazolines/pyrazoles in quantitative yields. (enamine.net)
- In the first strategy, thermal azide-alkyne Huisgen cycloaddition was utilized to attach electron-poor acetylenediamides using a branched glutamic acid linker to azidized PVC, incorporating four plasticizing moieties per attachment point. (escholarship.org)
- A versatile route for the synthesis of highly functionalized, polyanionic macromolecules based on dendritic polyglycerol was applied by means of the Huisgen-Sharpless-Meldal 1,3-dipolar cycloaddition ("click-reaction") of polyglycerolazide precursors and alkyne-functionalized anions such as sulfonates, carboxylates, phosphonates, and bisphosphonates. (fu-berlin.de)
Acetylene2
- As an alkyne , acetylene is bonded together in a triple bond. (hindlish.com)
- Under ambient conditions, [email protected] showed remarkable adsorption of alkynes and efficient separations of acetylene/ethylene, propyne/propylene, and butyne/1,3-butadiene mixtures, with unprecedented dynamic separation selectivities of 100, 92, and 83, respectively. (nankai.edu.cn)
Alkene and alkyne1
- Based on reductive ozonolysis reaction, how do you distinguish between an alkene and alkyne? (doubtnut.com)
Synthesis1
- Reduction of alkynes is a useful method for the stereoselective synthesis of disubstituted alkenes. (leslutinsduphoenix.com)
Aliphatic1
- The homodimerisation of terminal alkynes is found to proceed with high gem selectivity when employing aliphatic alkynes, whereas the reaction resulted in high Z-selectivity with aromatic alkynes, showing that the selectivity is dependent on the nature of the alkyne used. (hacettepe.edu.tr)
Alkanes1
- 1. Alkynes have physical properties similar to alkanes and alkenes. (preservearticles.com)
Reagents1
- Bifunctional 4-Arm PEG-Alkyne/NHS reagents have two functional groups Alkyne and NHS ester at specific ratios of 1:3, 2:2, 3:1. (creativepegworks.com)
Terminal9
- Glaser‐like coupling of terminal alkynes by thermal activation is extensively used in on‐surface chemistry. (usc.es)
- We used voltage pulses from the tip to trigger a Glaser‐like coupling between terminal alkyne carbons within a custom‐synthesized precursor molecule adsorbed on bilayer NaCl on Cu(111). (usc.es)
- How will you distinguish between terminal alkyne and nonteminal alkyne. (doubtnut.com)
- The carbanions generated by deprotonation of terminal alkynes are called acetylides. (hindlish.com)
- Vinyl silyl can be made from terminal alkyne or other methods. (hindlish.com)
- Because trialkylsilyl groups are very commonly used to protect the terminal C-H of an alkyne, pro- tiodesilylation back to the parent alkyne is an important transformation. (gelest.com)
- The same ruthenium complex was also shown to catalyse carboxylic acid (acetic acid, trichloroacetic acid, trans-2-octenoic acid, 4-cyclooctenoic acid) addition to terminal alkynes. (hacettepe.edu.tr)
- The reactions of enoic acids, showed a high selectivity towards carboxylic acid addition to the triple bond of terminal alkynes, rather than triple bond addition to the double bond of the enoic acids. (hacettepe.edu.tr)
- To evaluate the results obtained from the carboxylic acid addition reaction of terminal alkynes, the homodimerisation of terminal alkynes (phenylacetylene, 1-octyne, 1-heptyne) was also studied. (hacettepe.edu.tr)
Azides via2
- The orange-fluorescent Cy®3 Alkyne can be reacted with azides via a copper-catalysed click reaction (CuAAC). (dcbiosci.com)
- AZDye™ 546 Alkyne reacts with azides via a copper-catalyzed click reaction (CuAAC) to form a stable triazole linker. (clickchemistrytools.com)
Carboxylic acids2
- PPh 3 AuCl/AgPF 6 -catalyzed hydroacyloxylation of alkynes with carboxylic acids affords the Markonikov addition products, whereas PPh 3 AuCl/AgOTf catalyst gives the more stable isomerized products via the Markonikov products. (organic-chemistry.org)
- Copper-catalyzed fluoroalkylation of alkynes and alkynyl carboxylic acids has been achieved with high functional-group tolerance and excellent regio- and stereoselectivities. (researcher-app.com)
Reaction6
- The click reaction involves a copper-catalyzed triazole formation from an azide and an alkyne. (abpbio.com)
- The Cy3 alkyne is reactive with azide via a copper-catalyzed click reaction that allows the subsequent visualization by fluorescence spectroscopy. (abpbio.com)
- We report on a novel reaction protocol for the coupling of arenes with alkynes (the Fujiwara reaction), yielding products of formal trans-hydroarylation of the triple bond. (unipd.it)
- We discuss the applicability of this reaction protocol, which appears at present quite general with respect to the alkyne, albeit limited to electron-rich arenes. (unipd.it)
- We report here on a chromium-catalyzed addition reaction of an arylmagnesium bromide to an unactivated internal alkyne to afford an ortho-alkenylarylmagnesium bromide. (elsevier.com)
- This reaction likely proceeds via the insertion of an alkyne into an arylchromium species, alkenyl-to-aryl 1,4-chromium migration, and transmetalation between the resulting arylchromium species and the starting aryl Grignard reagent. (elsevier.com)
Orange-fluorescent1
- AZDye™ 546 Alkyne is a bright, orange-fluorescent alkyne-activated probe routinely used for imaging of low abundance azide-containing biomolecules. (clickchemistrytools.com)
Heteroaromatic1
- Reddy, MC, Manikandan, R & Jeganmohan, M 2013, ' Ruthenium-catalyzed aerobic oxidative cyclization of aromatic and heteroaromatic nitriles with alkynes: A new route to isoquinolones ', Chemical Communications , vol. 49, no. 54, pp. 6060-6062. (bgu.ac.il)
CuAAC1
- In the current work, two types of alkynes are shown to undergo rapid CuAAC reactions under both copper(II)- (via an induction period) and copper(I)-catalyzed conditions. (mdpi.com)
Nucleophilic1
- Angles for nucleophilic attack on alkynes were reviewed and redefined recently. (hindlish.com)
Cobalt1
- The cobalt alkyne complex [(prop-2-ynyl)-2-acetoxybenzoate]dicobalthexacarbonyl (Co-ASS) is an auspicious lead, which exhibits its anticancer activity mainly by inhibition of both cyclooxygenases (COX-1 and COX-2). (rsc.org)
Soluble1
- 3. Alkynes are sparingly soluble in polar solvents such as water but are readily soluble in organic solvents such as benzene, ether, acetone, etc. (preservearticles.com)
Organic compounds1
- Alkynes include the class of organic compounds when at least one or more carbon-carbon triple bond is present. (homeworkassignmenthelp.com)
Chemistry1
- Tobisu, M , Nakai, H & Chatani, N 2009, ' Platinum and ruthenium chloride-catalyzed cycloisomerization of 1-alkyl-2-ethynylbenzenes: Interception of π-activated alkynes with a benzylic C-H bond ', Journal of Organic Chemistry , vol. 74, no. 15, pp. 5471-5475. (elsevier.com)
Fluorescent1
- Tide Fluor™ 3 alkyne [TF3 alkyne] is a strong fluorescent dye used for labeling peptides and nucleotides. (scbt.com)
Quantitative1
- N-myristoylated proteins from VACV and the host were metabolically labelled with myristic acid alkyne during infection using quantitative chemical proteomics. (cdc.gov)
Bonds1
- The first type of the alkynes bears relatively acidic ethynyl C-H bonds, while the second type contains an N -(triazolylmethyl)propargylic moiety that produces a self-accelerating effect. (mdpi.com)
Functionality1
- The alkyne and NHS ester functionality are quantitated using spectroscopic techniques and colorimetric assays. (creativepegworks.com)
Click1
- 2016) Biocompatible Azide-Alkyne "Click" Reactions for Surface Decoration of Glyco-Engineered Cells. (jenabioscience.com)
Higher1
- Lower alkynes upto four carbon atoms are gases, those containing five to thirteen carbon atoms are liquids while higher alkynes are solids. (preservearticles.com)
General1
- Hidrocarburos con al menos un triple enlace en la porción lineal, con fórmula general Cn-H2n-2. (bvsalud.org)
Lower1
- The efficient removal of alkyne impurities for the production of polymer-grade lower olefins remains an important and challenging goal for many industries. (nankai.edu.cn)