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AlkynesCyclizationRhodiumClick ChemistryAlkenesStereoisomerismMolecular StructureCatalysisPropanolsAzidesPalladiumCycloparaffinsAlkadienesRutheniumCycloaddition ReactionAminationIminesIndolizidinesVinyl CompoundsOrganometallic CompoundsSilanesOrganogold CompoundsOrganosilicon CompoundsHempaIsocyanatesDiynesCombinatorial Chemistry TechniquesKetonesHeterocyclic CompoundsCopper
Alkynes
Hydrocarbons with at least one triple bond in the linear portion, of the general formula Cn-H2n-2.
Cyclization
Changing an open-chain hydrocarbon to a closed ring. (McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
Rhodium
Rhodium. A hard and rare metal of the platinum group, atomic number 45, atomic weight 102.905, symbol Rh. (Dorland, 28th ed)
Click Chemistry
Organic chemistry methodology that mimics the modular nature of various biosynthetic processes. It uses highly reliable and selective reactions designed to "click" i.e., rapidly join small modular units together in high yield, without offensive byproducts. In combination with COMBINATORIAL CHEMISTRY TECHNIQUES, it is used for the synthesis of new compounds and combinatorial libraries.
Alkenes
Unsaturated hydrocarbons of the type Cn-H2n, indicated by the suffix -ene. (Grant & Hackh's Chemical Dictionary, 5th ed, p408)
Stereoisomerism
The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
Molecular Structure
The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.
Catalysis
The facilitation of a chemical reaction by material (catalyst) that is not consumed by the reaction.
Propanols
Isomeric forms and derivatives of PROPANOL (C3H7OH).
Azides
Organic or inorganic compounds that contain the -N3 group.
Palladium
A chemical element having an atomic weight of 106.4, atomic number of 46, and the symbol Pd. It is a white, ductile metal resembling platinum, and following it in abundance and importance of applications. It is used in dentistry in the form of gold, silver, and copper alloys.
Cycloparaffins
Alicyclic hydrocarbons in which three or more of the carbon atoms in each molecule are united in a ring structure and each of the ring carbon atoms is joined to two hydrogen atoms or alkyl groups. The simplest members are cyclopropane (C3H6), cyclobutane (C4H8), cyclohexane (C6H12), and derivatives of these such as methylcyclohexane (C6H11CH3). (From Sax, et al., Hawley's Condensed Chemical Dictionary, 11th ed)
Alkadienes
Acyclic branched or unbranched hydrocarbons having two carbon-carbon double bonds.
Ruthenium
A hard, brittle, grayish-white rare earth metal with an atomic symbol Ru, atomic number 44, and atomic weight 101.07. It is used as a catalyst and hardener for PLATINUM and PALLADIUM.
Cycloaddition Reaction
Synthetic organic reactions that use reactions between unsaturated molecules to form cyclical products.
Amination
The creation of an amine. It can be produced by the addition of an amino group to an organic compound or reduction of a nitro group.
Imines
Indolizidines
Saturated indolizines that are fused six and five-membered rings with a nitrogen atom at the ring fusion. They are biosynthesized in PLANTS by cyclization of a LYSINE coupled to ACETYL COENZYME A. Many of them are naturally occurring ALKALOIDS.
Vinyl Compounds
Organometallic Compounds
A class of compounds of the type R-M, where a C atom is joined directly to any other element except H, C, N, O, F, Cl, Br, I, or At. (Grant & Hackh's Chemical Dictionary, 5th ed)
Silanes
Compounds similar to hydrocarbons in which a tetravalent silicon atom replaces the carbon atom. They are very reactive, ignite in air, and form useful derivatives.
Organogold Compounds
Organic compounds that contain GOLD as an integral part of the molecule. Some are used as ANTIRHEUMATIC AGENTS. The term chrysotherapy derives from an ancient Greek term for gold.
Organosilicon Compounds
Organic compounds that contain silicon as an integral part of the molecule.
Hempa
A chemosterilant agent that is anticipated to be a carcinogen.
Isocyanates
Organic compounds that contain the -NCO radical.
Diynes
Compounds with two triple bonds. Some of them are CYTOTOXINS.
Combinatorial Chemistry Techniques
A technology, in which sets of reactions for solution or solid-phase synthesis, is used to create molecular libraries for analysis of compounds on a large scale.
Ketones
Heterocyclic Compounds
Ring compounds having atoms other than carbon in their nuclei. (Grant & Hackh's Chemical Dictionary, 5th ed)
Copper
A heavy metal trace element with the atomic symbol Cu, atomic number 29, and atomic weight 63.55.

Smoothing of the thermal stability of DNA duplexes by using modified nucleosides and chaotropic agents. (1/688)

The effect of alkyltrimethylammonium ions on the thermostability of natural and modified DNA duplexes has been investigated. We have shown that the use of tetramethylammonium ions TMA+along with the chemical modification of duplexes allow the fine adjustment of T m and the possibility of obtaining several duplex systems with varied isostabilizedtemperatures, some of which show greater stability than those of natural DNA. This approach could be very useful for DNA sequencing by hybridization.  (+info)

Inhibition of glutathione synthesis with propargylglycine enhances N-acetylmethionine protection and methylation in bromobenzene-treated Syrian hamsters. (2/688)

The finding that liver necrosis caused by the environmental glutathione (GSH)-depleting chemical, bromobenzene (BB) is associated with marked impairment in O- and S-methylation of BB metabolites in Syrian hamsters raises questions concerning the role of methyl deficiency in BB toxicity. N-Acetylmethionine (NAM) has proven to be an effective antidote against BB toxicity when given after liver GSH has been depleted extensively. The mechanism of protection by NAM may occur via a replacement of methyl donor and/or via an increase of GSH synthesis. If replacement of the methyl donor is an important process, then blocking the resynthesis of GSH in the methyl-repleted hamsters should not decrease NAM protection. This hypothesis was examined in this study. Propargylglycine (PPG), an irreversible inhibitor of cystathionase, was used to inhibit the utilization of NAM for GSH resynthesis. Two groups of hamsters were pretreated with an intraperitoneal (ip) dose of PPG (30 mg/kg) or saline 24 h before BB administration (800 mg/kg, ip). At 5 h after BB treatment, an ip dose of NAM (1200 mg/kg) was given. Light microscopic examinations of liver sections obtained 24 h after BB treatment indicated that NAM provided better protection (P < 0.05) in the PPG + BB + NAM group than in the BB + NAM group. Liver GSH content, however, was lower in the PPG + BB + NAM group than in the BB + NAM group. The Syrian hamster has a limited capability to N-deacetylated NAM. The substitution of NAM with methionine (Met; 450 mg/kg) resulted in a higher level of GSH in the BB + Met group than in the BB + NAM group (P < 0.05). The enhanced protection by PPG in the PPG + BB + NAM group was accompanied by higher (P < 0.05) urinary excretions of specificO- and S-methylated bromothiocatechols than in the BB + NAM group. The results suggest that NAM protection occurs primarily via a replacement of the methyl donor and that methyl deficiency occurring in response to GSH repletion plays a potential role in BB toxicity.  (+info)

Inhibition of gene expression by anti-sense C-5 propyne oligonucleotides detected by a reporter enzyme. (3/688)

Using a reporter plasmid containing the luciferase gene under the control of the insulin-like growth factor 1 (IGF-1) promoter region [including its 5' untranslated region (UTR)], we demonstrate that a 17-mer oligophosphorothioate containing C-5 propyne pyrimidines is able to inhibit luciferase gene expression in the nanomolar concentration range when the anti-sense oligonucleotide is targeted either to a coding sequence in the luciferase gene or to the 5' UTR of the gene for IGF-1. Inhibition was obtained independently of whether the plasmid and the anti-sense oligonucleotide were co-transfected or transfected separately into hepatocarcinoma cells. However, the efficiency of inhibition by the anti-sense oligonucleotides was 10-fold greater in the first case. The unmodified oligophosphorothioate targeted to the 5' UTR of IGF-1 did not inhibit luciferase gene expression at a 100-fold higher concentration unless its length was increased from 17 to 21 nt, in which case an inhibition of gene expression was obtained and an IC50 of 200 nM was observed.  (+info)

Elevated expression of liver gamma-cystathionase is required for the maintenance of lactation in rats. (4/688)

Liver gamma-cystathionase activity increases in rats during lactation; its inhibition due to propargylglycine is followed by a significant decrease in lactation. This is reversible by N-acetylcysteine administration. To study the role of liver gamma-cystathionase and the intertissue flux of glutathione during lactation, we used lactating and virgin rats fed liquid diets. Virgin rats were divided into two groups as follows: one group was fed daily a diet containing the same amount of protein that was consumed the previous day by lactating rats (high protein diet-fed rats); the other virgin group was fed the normal liquid diet (control). The expression and activity of liver gamma-cystathionase were significantly greater in lactating rats and in high protein diet-fed virgin rats compared with control rats. The total glutathione [reduced glutathione (GSH) + oxidized glutathione (GSSG)] released per gram of liver did not differ in lactating rats or in high protein diet-fed rats, but it was significantly higher in these two groups than in control virgin rats. Liver size and the GSH + GSSG released by total liver were significantly higher in lactating rats than in high protein diet-fed virgin rats, and this difference was similar to the amount of glutathione taken up by the mammary gland (454.2 +/- 36.0 nmol/min). The uptake of total glutathione by the lactating mammary gland was much higher than the uptakes of free L-cysteine and L-cystine, which were negligible. These data suggest that the intertissue flux of glutathione is an important mechanism of L-cysteine delivery to the lactating mammary gland, which lacks gamma-cystathionase activity. This emphasizes the physiologic importance of the increased expression and activity of liver gamma-cystathionase during lactation.  (+info)

Guest exchange in an encapsulation complex: a supramolecular substitution reaction. (5/688)

Encapsulation complexes are reversibly formed assemblies in which small molecule guests are completely surrounded by large molecule hosts. The assemblies are held together by weak intermolecular forces and are dynamic: they form and dissipate on time scales ranging from milliseconds to days-long enough for many interactions, even reactions, to take place within them. Little information is available on the exchange process, how guests get in and out of these complexes. Here we report that these events can be slow enough for conventional kinetic studies, and reactive intermediates can be detected. Guest exchange has much in common with familiar chemical substitution reactions, but differs in some respects: no covalent bonds are made or broken, the substrate is an assembly rather than a single molecule, and at least four molecules are involved in multiple rate-determining steps.  (+info)

Effects of a lipoxygenase inhibitor, panaxynol, on vascular contraction induced by angiotensin II. (6/688)

We investigated whether a lipoxygenase inhibitor, panaxynol, affected the vascular contraction induced by angiotensin (Ang) II and the mean arterial pressure in spontaneously hypertensive rats (SHR). Panaxynol suppressed dose-dependently the contractile responses induced by 30 nM Ang II in isolated intact and endothelial cell-denuded aorta in the hamster. IC50 values in the intact and endothelial cell-denuded aorta were 23 and 20 microM, respectively. In SHR, the mean arterial pressure after injection of 30 and 60 mg/kg panaxynol was reduced, and the maximum hypotensive values were 23 and 48 mmHg, respectively. Thus, lipoxygenase products may affect the renin-angiotensin system.  (+info)

Similarity and dissimilarity in mode and mechanism of action between YT-146, a selective adenosine receptor A2 agonist, and adenosine in isolated canine hearts. (7/688)

To elucidate the differences in mode and mechanism of action between YT-146, a highly selective adenosine A2 receptor agonist, and adenosine, we compared their effects on coronary circulation and myocardium and modifications of these effects by glibenclamide, a blocker of ATP-sensitive potassium (K) channels, in three kinds of isolated, blood-perfused canine heart preparations. YT-146 and adenosine were injected i.a. In all preparations both YT-146 and adenosine increased coronary blood flow and in this respect YT-146 was about 5 times as potent as adenosine. The increase in blood flow caused by adenosine was transient, whereas that produced by YT-146 was biphasic; the transient increase was followed by a sustained one. In isolated, blood-perfused sinoatrial (SA) node preparations, YT-146 failed to affect sinus rate, whereas adenosine reduced sinus rate by about 38% at its maximum effect. In isolated, blood-perfused atrioventricular (AV) node preparations, when injected into the artery supplying the AV node, YT-146 exerted no effect on AV conduction time, whereas adenosine prolonged AV conduction time by about 17% at the maximum effect. In isolated, blood-perfused papillary muscle preparations, the force of contraction was affected by neither YT-146 nor adenosine. In the same preparations the effect of YT-146 in increasing coronary blood flow was antagonized by glibenclamide in such a manner that the maximum increase was suppressed, but that of adenosine was not. Reactive hyperemia induced by ischemia for 30 seconds was not affected by glibenclamide. These results suggest that although both YT-146 and adenosine produce an increase in coronary blood flow via adenosine A2 receptors, the opening of ATP- or glibenclamide-sensitive K channels is involved in the action of the former, but scarcely in the action of the latter. The opening of ATP- or glibenclamide-sensitive K-channels is less likely involved in reactive hyperemia.  (+info)

NAD(+)-dependent (S)-specific secondary alcohol dehydrogenase involved in stereoinversion of 3-pentyn-2-ol catalyzed by Nocardia fusca AKU 2123. (8/688)

An NAD(+)-dependent alcohol dehydrogenase was purified to homogeneity from Nocardia fusca AKU 2123. The enzyme catalyzed (S)-specific oxidation of 3-pentyn-2-ol (PYOH), i.e., part of the stereoinversion reaction for the production of (R)-PYOH, which is a valuable chiral building block for pharmaceuticals, from the racemate. The enzyme used a broad variety of secondary alcohols including alkyl alcohols, alkenyl alcohols, acetylenic alcohols, and aromatic alcohols as substrates. The oxidation was (S)-isomer specific in every case. The K(m) and Vmax for (S)-PYOH and (S)-2-hexanol oxidation were 1.6 mM and 53 mumol/min/mg, and 0.33 mM and 130 mumol/min/mg, respectively. The enzyme also catalyzed stereoselective reduction of carbonyl compounds. (S)-2-Hexanol and ethyl (R)-4-chloro-3-hydroxybutanoate in high optical purity were produced from 2-hexanone and ethyl 4-chloro-3-oxobutanoate by the purified enzyme, respectively. The K(m) and Vmax for 2-hexanone reduction were 2.5 mM and 260 mumol/min/mg. The enzyme has a relative molecular mass of 150,000 and consists of four identical subunits. The NH2-terminal amino acid sequence of the enzyme shows similarity with those of the carbonyl reductase from Rhodococcus erythropolis and phenylacetaldehyde reductase from Corynebacterium sp.  (+info)

organic chemistry - Correct definition of terminal alkynes? - Chemistry Stack Exchangeorganic chemistry - Correct definition of terminal alkynes? - Chemistry Stack Exchange
Youre right; the definition in your book is simplistic. A terminal alkyne would be better defined as an alkyne with the formula $\ce{RC_2H}$, differentiating from an internal alkyne, which would have the formula $\ce{RC_2R}$ and the added stipulation that neither R nor R can be a hydrogen. Equivalently stated as in Wikipedia, an internal alkyne has carbon substitutents on all acetylenic carbons, and a terminal alkyne is therefore not an internal alkyne because at least one acetylenic carbon has a hydrogen bonded to it.. The example formula you cite is vinylacetylene, systematic name butenyne or 1-buten-3-yne (heres your IUPAC nomenclature rules favoring double bonds at work; otherwise itd be ethynylbutene or similar). It is indeed an example of a terminal alkyne, having the exploded formula (C2H3)C2H.. ...
https://chemistry.stackexchange.com/questions/4854/correct-definition-of-terminal-alkynes
Evaluation of biofilm formation on novel copper-catalyzed azide-alkyne cycloaddition (CuAAC)-based resins for dental...Evaluation of biofilm formation on novel copper-catalyzed azide-alkyne cycloaddition (CuAAC)-based resins for dental...
Evaluation of biofilm formation on novel copper-catalyzed azide-alkyne cycloaddition (CuAAC)-based resins for dental restoratives Journal Article ...
https://experts.colorado.edu/display/pubid_233880
Hydrosilylation of alkynes catalysed by platinum on titania<...
TY - JOUR. T1 - Hydrosilylation of alkynes catalysed by platinum on titania. AU - Alonso, Francisco. AU - Buitrago, Robison. AU - Moglie, Yanina. AU - Ruiz-Martínez, Javier. AU - Sepúlveda-Escribano, Antonio. AU - Yus, Miguel. N1 - Generated from Scopus record by KAUST IRTS on 2019-08-08. PY - 2011/1/1. Y1 - 2011/1/1. N2 - The heterogeneous hydrosilylation of alkynes catalysed by platinum on titania is reported. A variety of hydrosilanes react with both terminal and internal alkynes to furnish the corresponding vinyl silanes in high yields and short reaction times as well as in a regio- and stereoselective manner. The catalyst can be easily recovered and reused in several consecutive cycles. © 2010 Elsevier B.V. All rights reserved.. AB - The heterogeneous hydrosilylation of alkynes catalysed by platinum on titania is reported. A variety of hydrosilanes react with both terminal and internal alkynes to furnish the corresponding vinyl silanes in high yields and short reaction times as well as ...
https://research.kaust.edu.sa/en/publications/hydrosilylation-of-alkynes-catalysed-by-platinum-on-titania
Rhodium-catalyzed oxidative cycloaddition of benzamides and alkynes via C-H/N-H activation<...Rhodium-catalyzed oxidative cycloaddition of benzamides and alkynes via C-H/N-H activation<...
TY - JOUR. T1 - Rhodium-catalyzed oxidative cycloaddition of benzamides and alkynes via C-H/N-H activation. AU - Hyster, Todd K.. AU - Rovis, Tomislav. PY - 2010/8/4. Y1 - 2010/8/4. N2 - The oxidative cycloaddition of benzamides and alkynes has been developed. The reaction utilizes Rh(III) catalysts in the presence of Cu(II) oxidants, and is proposed to proceed by N-H metalation of the amide followed by ortho C-H activation. The resultant rhodacycle undergoes alkyne insertion to form isoquinolones in good yield. The reaction is tolerant of extensive substitution on the amide, alkyne, and arene, including halides, silyl ethers, and unprotected aldehydes as substituents. Unsymmetrical alkynes proceed with excellent regioselectivity, and heteroaryl carboxamides are tolerated leading to intriguing scaffolds for medicinal chemistry. A series of competition experiments shed further light on the mechanism of the transformation and reasons for selectivity.. AB - The oxidative cycloaddition of benzamides ...
https://collaborate.princeton.edu/en/publications/rhodium-catalyzed-oxidative-cycloaddition-of-benzamides-and-alkyn
Rhodium(III)-Catalyzed Annulation of 4-Phenylquinazolines with internal Alkynes via Dual C−H Bond Functionalization - raiithRhodium(III)-Catalyzed Annulation of 4-Phenylquinazolines with internal Alkynes via Dual C−H Bond Functionalization - raiith
Rh(III)-catalyzed C−H bond annulation with alkynes has excogitated into a potent method for the preparation of highly substituted polycyclic aromatic and heteroaromatic compounds. Here Rh(III)-catalyzed annulation of 4-phenyl quinazolines with internal alkynes via dual C−H bond activation has been explored. The synthetic procedure has the advantages of high efficiency and functional group tolerance, excellent regioselectivity and broad substrate scope under mild conditions and some of the resulting products exhibit intense fluorescence in the solution state. Such structural motifs may important precursors for further transformations into biologically active compounds & π-conjugated functional materials such as organic semiconductors and luminescent materials which have broad prospect in future life.. ...
http://raiith.iith.ac.in/5714/
Ruthenium-Catalyzed Cross Coupling Reactions of Alkynes and Alkenes by Yuzhong ChenRuthenium-Catalyzed Cross Coupling Reactions of Alkynes and Alkenes by Yuzhong Chen
Transition-metal-mediated cross coupling reaction of alkynes and alkenes has recently gained increasing significance in organic chemistry because it represents an efficient method for the formation of new carbon-carbon bond. In recent years, two types of the coupling reactions have been developed: intramolecular couplings of enynes and intermolecular couplings of alkynes and alkenes. These results were classified into two mechanistic pathways, one not involving carbon-carbon bond cleavage, insertion mechanism, and the other involving carbon-carbon bond cleavage, metathesis mechanism. While the coupling reactions of alkynes with substituted alkenes have been well developed, there are very few reports on the coupling of alkynes with the simplest alkene, ethylene documented in the literature. Our research goal is to develop a new rutheniumbased system to study the coupling reactions of alkynes with ethylene, and extend its scope to enyne and substituted alkenes.
https://epublications.marquette.edu/theses/2433/
Well-defined (co)polypeptides bearing pendant alkyne groups<...
TY - JOUR. T1 - Well-defined (co)polypeptides bearing pendant alkyne groups. AU - Zhao, Wei. AU - Gnanou, Yves. AU - Hadjichristidis, Nikos. N1 - KAUST Repository Item: Exported on 2020-10-01 Acknowledgements: The research reported in this publication was supported by funding from King Abdullah University of Science and Technology (KAUST).. PY - 2016. Y1 - 2016. N2 - A novel metal-free strategy, using hydrogen-bonding catalytic ring opening polymerization of acetylene-functionalized N-carboxy anhydrites of α-amino acids, was developed for the synthesis of well-defined polypeptides bearing pendant alkyne groups. This method provides an efficient way to synthesize novel alkyne-functionalized homopolypeptides (A) and copolypeptides, such as AB diblock (B: non-functionalized), ABA triblock and star-AB diblock, as well as linear and star random copolypeptides, precursors of a plethora complex macromolecular architectures by click chemistry.. AB - A novel metal-free strategy, using hydrogen-bonding ...
https://research.kaust.edu.sa/en/publications/well-defined-copolypeptides-bearing-pendant-alkyne-groups
Synthesis of Isoquinolines from α-Aryl Vinyl Azides and Internal Alkynes by Rh-Cu Bimetallic Cooperation - Wang - 2011 -...Synthesis of Isoquinolines from α-Aryl Vinyl Azides and Internal Alkynes by Rh-Cu Bimetallic Cooperation - Wang - 2011 -...
Wang, Y.-F., Toh, K. K., Lee, J.-Y. and Chiba, S. (2011), Synthesis of Isoquinolines from α-Aryl Vinyl Azides and Internal Alkynes by Rh-Cu Bimetallic Cooperation. Angew. Chem., 123: 6049-6053. doi: 10.1002/ange.201101009 ...
http://onlinelibrary.wiley.com/doi/10.1002/ange.201101009/suppinfo
Alkyne synonyms, alkyne antonyms - FreeThesaurus.comAlkyne synonyms, alkyne antonyms - FreeThesaurus.com
Synonyms for alkyne in Free Thesaurus. Antonyms for alkyne. 2 synonyms for alkyne: acetylene, ethyne. What are synonyms for alkyne?
https://www.freethesaurus.com/alkyne
C1-Symmetric RhPhebox-Catalyzed Asymmetric Alkynylation of -Ketoesters.C1-Symmetric RhPhebox-Catalyzed Asymmetric Alkynylation of -Ketoesters.
Communications DOI: 10.1002/anie.201100252 Asymmetric Catalysis C1-Symmetric Rh/Phebox-Catalyzed Asymmetric Alkynylation of a-Ketoesters** Takashi Ohshima,* Takahito Kawabata, Yosuke Takeuchi, Takahiro Kakinuma, Takanori Iwasaki, Takayuki Yonezawa, Hajime Murakami, Hisao Nishiyama, and Kazushi Mashima* Catalytic asymmetric alkynylation of carbonyl compounds is one of the most efficient routes for the synthesis of optically active propargylic alcohols, which are useful and versatile building blocks for a variety of functionalized molecules, such as biologically active natural products.[1] In the initial stages of development of this transformation, stoichiometric amounts of metal reagents such as organolithium, organomagnesium, and diorganozinc compounds were used to increase the nucleophilicity of the alkyne and to prevent an undesired retro reaction.[1, 2] In terms of atom economy,[3] however, the direct in situ generation of a metal alkynylide species from terminal alkynes using a catalytic ...
https://www.docme.ru/doc/1911590/c1-symmetric-rhphebox-catalyzed-asymmetric-alkynylation-o..
Zinc-Catalysed Hydroboration of Terminal and Internal Alkynes ePrints@IIScZinc-Catalysed Hydroboration of Terminal and Internal Alkynes [email protected]
A regioselective hydroboration of alkynes has been developed by using commercially available zinc triflate as a catalyst, in the presence of catalytic amount of NaBHEt3. The reaction tolerates a wide range of terminal alkynes having several synthetically useful functional groups and proceeds regioselectively to furnish hydroborated products in moderate to excellent yields. This system shows moderate chemoselectivity towards terminal C equivalent to C bond over terminal and internal C=C bond and internal C equivalent to C bond.. ...
http://eprints.iisc.ac.in/63524/
Diversified polyoxovanadate derivatives obtained by copper(i)-catalysed azide-alkyne cycloaddition reaction: their synthesis...Diversified polyoxovanadate derivatives obtained by copper(i)-catalysed azide-alkyne cycloaddition reaction: their synthesis...
In this work, we confirmed that the copper-catalysed azide-alkyne cycloaddition (CuAAC) reaction is an effective method for the organic-functionalization of polyoxometalates (POMs). Herein, for the first time, four novel 1,2,3-triazole functionalized polyoxovanadate (POV) organic-inorganic hybrids, (Bu4N)2[V6O13{(O
http://pubs.rsc.org/en/content/articlelanding/2017/dt/c7dt03822d
A new sinthetic application of (dichloroiodo)benzene in reactions with alkenes and alkynes<...
TY - GEN. T1 - A new sinthetic application of (dichloroiodo)benzene in reactions with alkenes and alkynes. AU - Yusubova, R. J.. AU - Filimonov, V. D.. AU - Yusubov, M. S.. AU - Chi, Ki Whan. PY - 2004. Y1 - 2004. N2 - A convenient synthesis of vicinal methoxychlorides, methoxyiodides from alkenes and alkynes using PhICl2/CH3OH, I 2/PhICl2/CH3OH is described.. AB - A convenient synthesis of vicinal methoxychlorides, methoxyiodides from alkenes and alkynes using PhICl2/CH3OH, I 2/PhICl2/CH3OH is described.. KW - (dichloroiodo)Benzene. KW - Alkenes. KW - Alkynes. KW - Chloromethoxylation. KW - Iodomethoxylation. UR - http://www.scopus.com/inward/record.url?scp=29144459782&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=29144459782&partnerID=8YFLogxK. M3 - Conference contribution. AN - SCOPUS:29144459782. SN - 0780383834. SN - 9780780383838. VL - 2. SP - 97. EP - 98. BT - 8th Korea-Russia International Symposium on Science and Technology - Proceedings: KORUS 2004. ER - ...
https://tpu.pure.elsevier.com/ru/publications/a-new-sinthetic-application-of-dichloroiodobenzene-in-reactions-w
New oxidative transformations of alkenes and alkynes under the action of diacetoxyiodobenzene<...
TY - JOUR. T1 - New oxidative transformations of alkenes and alkynes under the action of diacetoxyiodobenzene. AU - Yusubov, M. S.. AU - Zholobova, G. A.. AU - Filimonova, I. L.. AU - Chi, Ki Whan. PY - 2004/8/1. Y1 - 2004/8/1. N2 - Treatment of alkenes and alkynes with diacetoxyiodobenzene activated by mineral and organic acids predominantly results in oxidative rearrangement. 1,4-Diphenylbutadiene in MeOH gives 3,4-dimethoxy-1,4-diphenylbut-1-ene.. AB - Treatment of alkenes and alkynes with diacetoxyiodobenzene activated by mineral and organic acids predominantly results in oxidative rearrangement. 1,4-Diphenylbutadiene in MeOH gives 3,4-dimethoxy-1,4-diphenylbut-1-ene.. KW - Alkenes. KW - Alkynes. KW - Diacetoxyiodobenzene. KW - Oxidative rearrangement. KW - Polyvalent iodine compounds. UR - http://www.scopus.com/inward/record.url?scp=14944340734&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=14944340734&partnerID=8YFLogxK. U2 - 10.1007/s11172-005-0027-8. DO - ...
https://tpu.pure.elsevier.com/en/publications/new-oxidative-transformations-of-alkenes-and-alkynes-under-the-ac
Chemical Properties Of The Alkynes | Alkyne Assignment Help | Alkyne Homework Help | Homework For AlkyneChemical Properties Of The Alkynes | Alkyne Assignment Help | Alkyne Homework Help | Homework For Alkyne
Best Chemical Properties Of The Alkynes Online Homework Help, Assignment Help providers on internet. 24 X 7 live online tutoring at Assignmenthelp.net.
http://www.assignmenthelp.net/assignment_help/chemical-properties-of-the-alkynes
Synthesis of Strained 1,3-Diene Macrocycles via Copper-Mediated Castro-Stephens Coupling/Alkyne Reduction Tandem Reactions<...
TY - JOUR. T1 - Synthesis of Strained 1,3-Diene Macrocycles via Copper-Mediated Castro-Stephens Coupling/Alkyne Reduction Tandem Reactions. AU - Li, Wei. AU - Schneider, Christopher M.. AU - Georg, Gunda I.. PY - 2015/8/7. Y1 - 2015/8/7. N2 - A copper-mediated macrocyclization involving the reaction of a vinyl iodide and a terminal alkyne followed by an in situ reduction of the enyne intermediate is reported. The reaction generates a conjugated Z-double bond within a strained medium-size lactone, lactam, or ether macrocycle. A variety of macrocyclic compounds bearing different ring sizes and functionalities were synthesized. A complementary stepwise procedure was also developed for less strained ring systems.. AB - A copper-mediated macrocyclization involving the reaction of a vinyl iodide and a terminal alkyne followed by an in situ reduction of the enyne intermediate is reported. The reaction generates a conjugated Z-double bond within a strained medium-size lactone, lactam, or ether ...
https://minnesota-staging.pure.elsevier.com/en/publications/synthesis-of-strained-13-diene-macrocycles-via-copper-mediated-ca
Guanidine) copper complex-catalyzed enantioselective dynamic kinetic allylic alkynylation under biphasic condition | DR-NTUGuanidine) copper complex-catalyzed enantioselective dynamic kinetic allylic alkynylation under biphasic condition | DR-NTU
Highly enantioselective allylic alkynylation of racemic bromides under biphasic condition is furnished in this report. This approach employs functionalized terminal alkynes as pro-nucleophiles and provides 6- and 7-membered cyclic 1,4-enynes with high yields and excellent enantioselectivities (up to 96% ee) under mild conditions. Enantioretentive derivatizations highlight the synthetic utility of this transformation. Cold-spray ionization mass spectrometry (CSI-MS) and X-ray crystallography were used to identify some catalytic intermediates, which include guanidinium cuprate ion pairs and a copper-alkynide complex. A linear correlation between the enantiopurity of the catalyst and reaction product indicates the presence of a copper complex bearing a single guanidine ligand at the enantio-determining step. Further experimental and computational studies supported that the alkynylation of allylic bromide underwent an anti-SN2 pathway catalyzed by nucleophilic cuprate species. Moreover, ...
https://dr.ntu.edu.sg/handle/10356/137033
Bismuth(III)-Catalyzed hydration of terminal alkynes: Sustainable synthesis of methyl ketones in batch and flow<...
TY - JOUR. T1 - Bismuth(III)-Catalyzed hydration of terminal alkynes. T2 - Sustainable synthesis of methyl ketones in batch and flow. AU - Ötvös, Sándor B.. AU - Szécsényi, Zsanett. AU - Fülöp, F.. PY - 2019/8/5. Y1 - 2019/8/5. N2 - Environmentally benign synthesis of methyl ketones is demonstrated via unprecedented bismuth(III)-catalyzed activation and Markovnikov-type hydration of terminal acetylenes. Besides a batch process operating under reasonably mild conditions, a chemically intensified high-temperature continuous-flow methodology has also been developed using a coil reactor. The preparative capabilities of the flow process were demonstrated with multigram-scale alkyne hydrations. The methods presented rely on readily available bismuth(III) salts as green catalysts and exhibit less environmental concerns than earlier methods.. AB - Environmentally benign synthesis of methyl ketones is demonstrated via unprecedented bismuth(III)-catalyzed activation and Markovnikov-type hydration ...
https://hungary.pure.elsevier.com/hu/publications/bismuthiii-catalyzed-hydration-of-terminal-alkynes-sustainable-sy
Alkynes Are A Blank CanvasAlkynes Are A Blank Canvas
Acetylene is the ultimate carbon building block (on paper, anyway!). It bears two relatively acidic C-H bonds (pKa 25) and can therefore be alkylated (i.e. deprotonated to give its conjugate base, then treated with an alkyl halide) on either end giving either a mono-substituted (also known as a terminal alkyne) or di-substituted (internal) alkyne as desired. This is important because in first semester organic chemistry, this reaction represents an important means of extending the carbon chain. You dont learn that many reactions that form C-C. This reaction comes up a lot ...
https://staging.masterorganicchemistry.com/2013/06/24/alkynes-are-a-blank-canvas/
PPT - Alkynes Chapters 7,8 PowerPoint Presentation - ID:171874PPT - Alkynes Chapters 7,8 PowerPoint Presentation - ID:171874
Outline1. Bonding in alkynes. sp-Hybridization2. Physical properties and nomenclature of alkynes 3. Preparation and use of alkynes4. Addition to triple bonds. Hydrohalogenation5. Addition to triple bonds. Hydration6. Addition to triple bonds. Hydroboration-oxidation7. Addition to triple bonds....
https://www.slideserve.com/omer/alkynes-chapters-7-8
9. Alkynes: An Introduction to Organic Synthesis - ppt video online download9. Alkynes: An Introduction to Organic Synthesis - ppt video online download
Alkynes Hydrocarbons that contain carbon-carbon triple bonds C≡C Acetylene, the simplest alkyne is produced industrially from methane and steam at high temperature Our study of alkynes provides an introduction to organic synthesis, the preparation of organic molecules from simpler organic molecules
http://slideplayer.com/slide/4335432/
Hydrofluoroarylation of alkynes with fluoroarenes<...
TY - JOUR. T1 - Hydrofluoroarylation of alkynes with fluoroarenes. AU - Kanyiva, Stephen Kyalo. AU - Kashihara, Natsuko. AU - Nakao, Yoshiaki. AU - Hiyama, Tamejiro. AU - Ohashi, Masato. AU - Ogoshi, Sensuke. PY - 2010/11/21. Y1 - 2010/11/21. N2 - A combination of Ni(cod)2 and PCyp3 is found to be an effective catalyst for chemoselective activation of the C-H bond of fluoroarenes over C-F bonds followed by insertion of alkynes to allow direct alkenylation of the electron-deficient arenes. The characteristics of the reactions are: a C-H bond ortho to a fluorine substituent is selectively activated; the reactivity of fluorobenzenes is roughly proportional to the number of fluorine atoms. The reaction conditions tolerate a broad range of both alkynes and fluoroarenes containing both electron-withdrawing and -donating groups, thus allowing efficient synthesis of a variety of substituted ethenes containing a fluoroaryl motif in high regio- and stereoselective manners. Mechanistic studies including ...
https://waseda.pure.elsevier.com/en/publications/hydrofluoroarylation-of-alkynes-with-fluoroarenes
A strategy for conditional orthogonal sequential CuAAC reactions using a protected aromatic ynamine<...A strategy for conditional orthogonal sequential CuAAC reactions using a protected aromatic ynamine<...
TY - JOUR. T1 - A strategy for conditional orthogonal sequential CuAAC reactions using a protected aromatic ynamine. AU - Hatit, Marine Z. C.. AU - Seath, Ciaran P.. AU - Watson, Allan J. B.. AU - Burley, Glenn A.. N1 - This document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal of Organic Chemistry, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.joc.7b00545.. PY - 2017/4/28. Y1 - 2017/4/28. N2 - A method for conditional control of orthogonal sequential Cu-catalyzed azide alkyne cycloaddition (CuAAC) reactions is reported. The inherent reactivity of an aromatic ynamine is controlled by a silyl protecting group that allows the selective CuAAC reaction of less reactive alkynes. Alternatively, the same protected ynamine undergoes selective CuAAC reaction via silyl deprotection in situ to give theynamine click products. This ...
https://pureportal.strath.ac.uk/en/publications/a-strategy-for-conditional-orthogonal-sequential-cuaac-reactions-
the type of hybridization in alkynes is
This has some implications in the properties and chemical reactivity of sigma and pi bonds. Ethyne or acetylene, HC=CH, is the simplest alkyne example. The process for understanding the sp hybridization process for carbon is basically an extension of the other two types (sp 3 and sp 2). Thus, in acetylene (ethyne), there are two unhybridized orbitals, which, by convention are and (see figure below): Figure: Illustrating the sp orbitals. The triple bonded carbon atoms of acetylene aresp hybridized. The sigma bond is short and strong. E)An alkyne reacts as an electrophile,and is therefore electron poor. Type of â ¦ You should try to work out this scheme on your own and see if your predictions agree with those presented in the textbook. is related to Unsaturated Hydrocarbons Quiz. The Structure of Ethyne (Acetylene): sp Hybridization ** Hydrocarbons in which two carbon atoms share three pairs of electrons between them, and are thus bonded by a triple bond, are called alkynes. Correspondingly, ...
http://worthytravel.com/xke1mp2/the-type-of-hybridization-in-alkynes-is-2fbe38
Highly Chemo- and Stereoselective Transfer Semihydrogenation of Alkynes Catalyzed by a Stable, Well-Defined Manganese(II)...
Herein we report unprecedented manganese-catalyzed semihydrogenation of internal alkynes to (Z)-alkenes using ammonia borane as a hydrogen donor. The reaction is catalyzed by a pincer complex of the earth-abundant manganese(II) salt in the absence of any additives, base, or superhydride. The ammonia borane smoothly reduces the manganese precatalyst [Mn(II)-PNP][Cl]2 to the catalytically active species [Mn(I)-PNP]-hydride in the triplet spin state. This manganese hydride is highly stabilized by complexation with the alkyne substrate. Computational density functional theory (DFT) analysis studies of the reaction mechanism rationalize the origin of stereoselectivity toward formation of (Z)-alkenes ...
https://accedacris.ulpgc.es/handle/10553/74774
Buy Alkyne functionalized | Alkyne functionalized Online : MKNano.comBuy Alkyne functionalized | Alkyne functionalized Online : MKNano.com
Alkyne functionalized Single layer graphene Flake size: 0.5-5 microns. Thickness: Single atomic layer >80% Purity: Carbon contents over 80% Alkyne functionalized online from Mknano.com.
http://mknano.com/Graphene-Fullerenes/Graphene/Functionalized-Single-Layer-Graphene-in-Aqueous-Solution/Alkyne-functionalized
Alkynes and Their Reactions - PDFAlkynes and Their Reactions - PDF
Alkynes and Their Reactions Naming Alkynes Alkynes are named in the same general way that alkenes are named. In the IUPAC system, change the ane ending of the parent alkane name to the suffix yne. Choose
http://docplayer.net/22407690-Alkynes-and-their-reactions.html
PPT - ALKYnes sem 1: 2011/2012 PowerPoint Presentation - ID:2192169PPT - ALKYnes sem 1: 2011/2012 PowerPoint Presentation - ID:2192169
ALKYnes sem 1: 2011/2012. Khadijah Hanim bt Abdul Rahman School of Bioprocess Engineering, UniMAP Week 5: 13/10/2011 [email protected] Learning outcomes. Structure, nomenclature and naming alkynes DEFINE and ILLUSTRATE the principle in naming alkynes on few examples...
https://www.slideserve.com/lucian/alkynes-sem-1-2011-2012
Completely regioselective insertion of unsymmetrical alkynes into electron-deficient alkenes for the synthesis of new...Completely regioselective insertion of unsymmetrical alkynes into electron-deficient alkenes for the synthesis of new...
A Lewis acid-catalyzed insertion of unsymmetrical alkynes into electron-deficient alkenes was developed for the first time, and used to produce 34 hitherto unreported pentacyclic benzo[5,6]chromeno[2,3-b]indoles with generally good yields and complete stereoselectivity. A Yb(OTf)3-catalyzed reaction between
https://pubs.rsc.org/en/content/articlelanding/2019/cc/c9cc08762a/unauth
Learning CHEMISTRY for IIT JEE: JEE 2008 Organic Chemistry SyllabusLearning CHEMISTRY for IIT JEE: JEE 2008 Organic Chemistry Syllabus
Preparation, properties and reactions of alkenes and alkynes: Physical properties of alkenes and alkynes (boiling points, density and dipole moments); Acidity of alkynes; Acid catalysed hydration of alkenes and alkynes (excluding the stereochemistry of addition and elimination); Reactions of alkenes with KMnO4 and ozone; Reduction of alkenes and alkynes; Preparation of alkenes and alkynes by elimination reactions; Electrophilic addition reactions of alkenes with X2, HX, HOX and H2O (X=halogen); Addition reactions of alkynes; Metal acetylides ...
http://iit-jee-chemistry.blogspot.com/2007/12/jee-2008-organic-chemistry-syllabus.html
JAIRO | Rhodium-Catalyzed Intermolecular Alkyne Cyclotrimerization Route to a Functionalized Cycloparaphenylene
Rhodium-Catalyzed Intermolecular Alkyne Cyclotrimerization Route to a Functionalized CycloparaphenyleneRhodium-Catalyzed Intermolecular Alkyne Cyclotrimerization Route to a Functionalized Cycloparaphenylene ...
http://jairo.nii.ac.jp/0083/00229021/en
中国科学院上海有机化学研究所机构知识库(SIOC OpenIR): Metal-Free Oxidative Trifluoromethylthiolation of Terminal Alkynes with CF3SiMe3 and...
A metal-free oxidative trifluoromethyl-thiolation of terminal alkynes using readily available CF3SiMe3 and elemental sulfur at room temperature has been developed. This reaction provides an efficient and convenient method for the preparation of alkynyl trifluoromethyl sulfides bearing a wide range of functional groups. Preliminary investigation revealed that elemental sulfur instead of air acted as the oxidant ...
http://ir.sioc.ac.cn/handle/331003/28325
Dual Inhibition of Mycobacterial Fatty Acid Biosynthesis and Degradation by 2-Alkynoic Acids<...Dual Inhibition of Mycobacterial Fatty Acid Biosynthesis and Degradation by 2-Alkynoic Acids<...
TY - JOUR. T1 - Dual Inhibition of Mycobacterial Fatty Acid Biosynthesis and Degradation by 2-Alkynoic Acids. AU - Morbidoni, Hector R.. AU - Vilchèze, Catherine. AU - Kremer, Laurent. AU - Bittman, Robert. AU - Sacchettini, James C.. AU - Jacobs, William R.. N1 - Funding Information: H.R.M. is a Career Investigator of Consejo de Investigaciones de la Universidad Nacional de Rosario (CIURN), Argentina. This work was supported by National Institutes of Health grant AI43268. L.K. is supported by a grant from the Centre National de la Recherche Scientifique (Actions Thématiques et Incitatives sur Programmes Microbiologie Fondamentale).. PY - 2006/3. Y1 - 2006/3. N2 - 2-Hexadecynoic acid and 2-octadecynoic acid have cidal activity against Mycobacterium smegmatis and Mycobacterium bovis BCG. At subinhibitory concentrations, M. smegmatis rapidly transformed [1-14C]-2-hexadecynoic acid into endogenous fatty acids and elongated them into mycolic acids. Toxic concentrations of 2-hexadecynoic acid ...
https://einstein.pure.elsevier.com/en/publications/dual-inhibition-of-mycobacterial-fatty-acid-biosynthesis-and-degr
Catalytic Enantioselective Addition of Terminal Alkynes to Aldehydes: Preparation of (S)-(-)-1,3-Diphenyl-2-Propyn-1-ol and (S)...
TY - JOUR. T1 - Catalytic Enantioselective Addition of Terminal Alkynes to Aldehydes: Preparation of (S)-(-)-1,3-Diphenyl-2-Propyn-1-ol and (S)-(-)-4-Methyl-1-Phenyl-2-Pentyn-1,4-Diol. AU - Takita, Ryo. AU - Harada, Shinji. AU - Ohshima, Takashi. AU - Matsunaga, Shigeki. AU - Shibasaki, Masakatsu. PY - 2008. Y1 - 2008. U2 - 10.1002/0471264229.os085.13. DO - 10.1002/0471264229.os085.13. M3 - Article. VL - 85. JO - Organic Syntheses. JF - Organic Syntheses. SN - 0078-6209. ER - ...
https://kyushu-u.pure.elsevier.com/en/publications/catalytic-enantioselective-addition-of-terminal-alkynes-to-aldehy-2
Development of Acid, Silver, and Solvent-Free Gold-Catalyzed Hydroelem by Daniel Vincent FraccicaDevelopment of Acid, Silver, and Solvent-Free Gold-Catalyzed Hydroelem by Daniel Vincent Fraccica
ABSTRACT FOR PART I: HYDROPHENOXYLATION REACTIONS CATALYZED BY ARYLGOLD(I) COMPOUNDS Both carbine and phosphine ligated arylgold(I) compounds have been synthesized and investigated as single-component catalysts for the hydrophenoxylation of unactivated internal alkynes to yield vinyl ethers. Catalysts containing either JohnPhos or IPr/SIPr were found to be the most efficient catalysts during the screening process. Electron-withdrawing and electron-donating groups on the phenols were tolerated using these catalysts. No silver salts, acids, or solvents were needed for the catalysis, and either microwave or conventional heating afforded moderate to excellent yields of the vinyl ethers. ABSTRACT FOR PART II: ARYLGOLD(I) COMPOUNDS TO PROMOTE THE ADDITION OF DIPHENYLPHOSPHINIC ACID TO TERMINAL ALKYNES Arylgold compounds were investigated as single component catalysts for the addition of diphenylphosphinic acid to terminal alkynes using a microwave reactor. Both carbene and phosphine ligated compounds were
https://digitalcommons.bucknell.edu/masters_theses/133/
hydration of alkyneshydration of alkynes
A mild strategy for highly regioselective hydration of the alkynes (internal and terminal) has been developed employing intramolecular ketone as the directing group under Ag(I) catalysis. were using acid to catalyze this transition. For terminal alkynes the addition of water follows the Markovnikov rule, as in the second example below, and the final product ia a methyl ketone ( except for acetylene, shown in the first example ). And then we have H2O and H2SO4 are If youre seeing this message, it means were having trouble loading external resources on our website. So this is my enol form. see a very similar reaction where we do a base-catalyzed mechanism for this arrangement in a few minutes here. Now the equilibrium is actually In contrast, the indirect hydration by the reaction sequence of hydroboration, oxidation and hydrolysis results in the anti-Markovnikov product. acid-catalyzed tautomerization. The first step is an acid/base reaction where the π electrons of the triple bond acts as a ...
https://diobeth.org/.tmb/forum/hwb0oig.php?e0ffba=hydration-of-alkynes
Phosphoramidate-Assisted Alkyne Activation: Probing the Mechanism of Proton Shuttling in a N,O-Chelated Cp*Ir(III) Complex |...Phosphoramidate-Assisted Alkyne Activation: Probing the Mechanism of Proton Shuttling in a N,O-Chelated Cp*Ir(III) Complex |...
Ligand lability offers a unique opportunity for access to metal-ligand cooperativity (MLC), helping to direct new organometallic and catalytic reactions. In recent years, ligand-assisted C-H bond activation and, more generally, proton migration have been of particular interest. This paper describes a detailed computational study into the mechanism, as well as the region and stereoselectivity, observed in a recently reported transformation where MLC in a 16-electron iridium(III) phosphoramidate complex plays a critical role in directing the activation of terminal alkynes toward the generation of novel five-membered (E)-vinyloxyirida(III)cycles. Five possible pathways for the formation of such products were investigated. Based on our findings, it is proposed that the reaction proceeds via a ligand-assisted proton shuttle (LAPS) mechanism, where the phosphoramidate phosphoryl (P=O) group assists in both alkyne C-H bond activation and C-H bond formation to form a vinylidene intermediate. Next, C-O ...
https://www.chem.ubc.ca/phosphoramidate-assisted-alkyne-activation-probing-mechanism-proton-shuttling-no-chelated-cpiriii
Grafting of poly(ethylene glycol) on click chemistry modified Si(100) surfacesGrafting of poly(ethylene glycol) on click chemistry modified Si(100) surfaces
Poly(ethylene glycol) (PEG) is one of the most extensively studied antifouling coatings due to its ability to reduce protein adsorption and improve biocompatibility. Although the use of PEG for antifouling coatings is well established, the stability and density of PEG layers are often inadequate to provide optimum antifouling properties. To improve on these shortcomings, we employed the stepwise construction of PEG layers onto a silicon surface. Acetylene-terminated alkyl monolayers were attached to nonoxidized crystalline silicon surfaces via a one-step hydrosilylation procedure with 1,8-nonadiyne. The acetylene-terminated surfaces were functionalized via a copper-catalyzed azide-alkyne cycloaddition (CuAAC) reaction of the surface-bound alkynes with an azide to produce an amine terminated layer. The amine terminated layer was then further conjugated with PEG to produce an antifouling surface. The antifouling surface properties were investigated by testing adsorption of human serum albumin ...
https://espace.curtin.edu.au/handle/20.500.11937/36024
Alkyne - WikipediaAlkyne - Wikipedia
In systematic chemical nomenclature, alkynes are named with the Greek prefix system without any additional letters. Examples include ethyne or octyne. In parent chains with four or more carbons, it is necessary to say where the triple bond is located. For octyne, one can either write 3-octyne or oct-3-yne when the bond starts at the third carbon. The lowest number possible is given to the triple bond. When no superior functional groups are present, the parent chain must include the triple bond even if it is not the longest possible carbon chain in the molecule. Ethyne is commonly called by its trivial name acetylene.. In chemistry, the suffix -yne is used to denote the presence of a triple bond. In organic chemistry, the suffix often follows IUPAC nomenclature. However, inorganic compounds featuring unsaturation in the form of triple bonds may be denoted by substitutive nomenclature with the same methods used with alkynes (i.e. the name of the corresponding saturated compound is modified by ...
https://en.wikipedia.org/wiki/Alkyne
Copper-catalyzed oxidative [2 + 2 + 1] cycloaddition: regioselective synthesis of 1,3-oxazoles from internal alkynes and...Copper-catalyzed oxidative [2 + 2 + 1] cycloaddition: regioselective synthesis of 1,3-oxazoles from internal alkynes and...
A free platform for explaining your research in plain language, and managing how you communicate around it - so you can understand how best to increase its impact.
https://www.growkudos.com/publications/10.1039%25252Fc2sc21041j/reader
中国科学院大连化学物理研究所机构知识库(DICP OpenIR): Mild and Efficient Ir(III)-Catalyzed Direct C−H Alkynylation of N‑Phenoxyacetamides with...
Jie Zhou,Jingjing Shi,Qi ZS,et al. Mild and Efficient Ir(III)-Catalyzed Direct C−H Alkynylation of N‑Phenoxyacetamides with Terminal Alkyne[J]. ACS Catalysis,2016,6(0):6999 ...
http://cas-ir.dicp.ac.cn/handle/321008/148312
Non-fluorescent alkynesNon-fluorescent alkynes
Various non-fluorescent alkynes for copper-catalyzed Click Chemistry. Fluorescent dye alkynes are listed under Reactive dyes category.
https://www.lumiprobe.com/catalog/click-chemistry-alkynes
Organic Chemistry/Alkynes - Wikibooks, open books for an open worldOrganic Chemistry/Alkynes - Wikibooks, open books for an open world
As you should know already, carbon is generally found in a tetravalent state - it forms four covalent bonds with other atoms. As you know from the section on alkenes, all four bonds are not necessarily to different atoms, because carbon atoms can double-bond to one another. What this does is create the appearance of only being bound to three other atoms, but in actuality four bonds exist. Alkenes are molecules that consist of carbon and hydrogen atoms where one or more pairs of carbon atoms participate in a double bond, which consists of one sigma (σ) and one pi (π) bond. Alkynes are also molecules consisting of carbon and hydrogen atoms, but instead of forming a double bond with only one sigma (σ) and one pi (π) bond, the alkyne has at least one pair of carbon atoms who have a σ and two π bonds -- a triple bond. The carbon-carbon triple bond, then, is a bond in which the carbon atoms share an s and two p orbitals to form just one σ and two π bonds between them. This results in a linear ...
https://en.m.wikibooks.org/wiki/Organic_Chemistry/Alkynes
Raman imaging of alkyne as a small tag for biological molecules | (2012) | Fujita | Publications | SpieRaman imaging of alkyne as a small tag for biological molecules | (2012) | Fujita | Publications | Spie
Role of small molecules such as drugs or metabolites in cells is commonly studied by fluorescence microscopy in which a fluorescent label is attached to the molecule. However, fluorescent labels are typically large that often interfere with the normal cellular function of the molecule. To avoid the use of bulky fluorescent labels, we introduce a technique that uses a simple small chemical tag called alkyne consisting of two carbons connected by a triple bond. The alkyne-tagged molecule is imaged using Raman microscopy that detects the strong Raman signal from the CC triple bond stretching vibration (~2120 cm-1). Because the alkyne signal is located in the silent region of the cell (1800-2700 cm-1), it does not interfere with any intrinsic cellular Raman signals. Here, we demonstrate this technique by showing Raman images of an alkyne-tagged component of DNA in a living cell using a slit-scanning confocal Raman microscope. This fast imaging technique is based on a line-shaped focus illumination ...
http://spie.org/Publications/Proceedings/Paper/10.1117/12.907984
Alkyne Reactions & Tautomerization: Crash Course Organic Chemistry #18
Carbon-carbon double bonds are pretty common in nature, but triple bonds between carbons, called alkynes, are not. When alkynes...
https://bagoscoop.github.io/videos/watch/alkyne-reactions-tautomerization-crash-course-organic-chemistry-18
Dr. Carolyn Bertozzi pioneers bioorthogonal chemistry to study molecules within living systems - IPWatchdog.com | Patents &...Dr. Carolyn Bertozzi pioneers bioorthogonal chemistry to study molecules within living systems - IPWatchdog.com | Patents &...
Bioorthogonal chemistry was pioneered by Dr. Carolyn Bertozzi, a 2017 inductee into the National Inventors Hall of Fame. Her work in Immunology earned her--
http://www.ipwatchdog.com/2017/10/05/evolution-of-tech-dr-carolyn-bertozzi-invents-bioorthogonal-chemistry-to-study-molecules-within-living-systems/id=88882/
Alkenes & Alkynes - Crash Course Chemistry #41 lesson plan | SpiralAlkenes & Alkynes - Crash Course Chemistry #41 lesson plan | Spiral
Alkenes & Alkynes - Crash Course Chemistry #41 - lesson plan ideas from Spiral. Tagged under: Chemistry (Professional Field),crash ,chemistry,molecule,energy,chemical bonds,Leucippus,atomic theory, nucleus,organic chemistry,Organic Chemistry (Field Of Study),alkanes,isomers,structure,alkenes,alkynes,naming rules,cis trans isomerism,hydrogenation,halogenation,polymerization,triglycerides,names fats
https://spiral.ac/sharing/3gcd8rj/alkenes-alkynes-crash-course-chemistry-41
PA (Propargyl Alcohol) - Lapointe Uluslar Arası Ticaret | Danışmanlık
Toxicocinétique et métabolisme Lalcool propargylique (Propargil Alkol, Propargyl Alcohol) est probablement métabolisé en aldéhyde propargylique. Cette oxydation a été démontrée in vitro dans des expériences avec la catalase obtenue à partir de foie de bovin. Des expériences in vitro avec des microsomes hépatiques de rats induits par le phénobarbital ont révélé de faibles niveaux de liaison de lalcool propargylique (Propargil Alkol, Propargyl Alcohol) au cytochrome P450 (BG Chemie 1999). 3 Effets chez lhomme Il ny a pas de données sur les effets chez lhomme dune exposition à lalcool propargylique (Propargil Alkol, Propargyl Alcohol). 262 Propargyl Alcohol (Propargil Alkol, Propargyl Alcohol) Volume 21 Propargyl Alcohol (Propargil Alkol, Propargyl Alcohol) 4 Expérimentation animale et études in vitro 4.1 Toxicité aiguë Lalcool propargylique (Propargil Alkol, Propargyl Alcohol) sest avéré toxique après administration orale, application cutanée et exposition par ...
https://lapointe.com.tr/en/pa-propargyl-alcohol-2
irdye compounds for labelingirdye compounds for labeling
LI-COR now offers a portfolio of Click Chemistry reagents for copper-catalyzed and copper-free methods. These products offer researchers flexibility to choose the correct reagent for a diverse array of applications. LI-COR Click Chemistry reagents include IRDye® 800CW, IRDye 680RD, and IRDye 650 infrared fluorescent dyes labeled with DBCO, azide, or alkyne groups. Click Chemistry utilizes pairs of reagents that exclusively react with each other and are effectively inert to naturally-occurring functional groups such as amines. Unlike affinity interactions such as streptavidin-biotin, Click Chemistry forges covalent bonds between the reacting partners to deliver stable bioconjugates.. Click Chemistry reactions can be categorized into two separate groups, copper-catalyzed or copper-free. Copper-catalyzed Click Chemistry is used for initiating reactions between azides and alkynes. These reactions are also known as Copper-Catalyzed Azide-Alkyne Cycloaddition (CuAAC). Although they initiate and ...
http://www.licor.com/bio/blog/tag/irdye-compounds-for-labeling/
dbco groupsdbco groups
LI-COR now offers a portfolio of Click Chemistry reagents for copper-catalyzed and copper-free methods. These products offer researchers flexibility to choose the correct reagent for a diverse array of applications. LI-COR Click Chemistry reagents include IRDye® 800CW, IRDye 680RD, and IRDye 650 infrared fluorescent dyes labeled with DBCO, azide, or alkyne groups. Click Chemistry utilizes pairs of reagents that exclusively react with each other and are effectively inert to naturally-occurring functional groups such as amines. Unlike affinity interactions such as streptavidin-biotin, Click Chemistry forges covalent bonds between the reacting partners to deliver stable bioconjugates.. Click Chemistry reactions can be categorized into two separate groups, copper-catalyzed or copper-free. Copper-catalyzed Click Chemistry is used for initiating reactions between azides and alkynes. These reactions are also known as Copper-Catalyzed Azide-Alkyne Cycloaddition (CuAAC). Although they initiate and ...
http://www.licor.com/bio/blog/tag/dbco-groups/
Photo-mediated copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) click reactions for forming polymer networks as shape...Photo-mediated copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) click reactions for forming polymer networks as shape...
Photo-mediated copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) click reactions for forming polymer networks as shape memory materials Journal Article ...
https://experts.colorado.edu/display/pubid_93364
talks.cam : Coordination-Assisted Bioorthogonal Chemistry: Bringing Orthogonality in the Tetrazine Ligation with (strained)...talks.cam : Coordination-Assisted Bioorthogonal Chemistry: Bringing Orthogonality in the Tetrazine Ligation with (strained)...
If you have a question about this talk, please contact .. The development of bioorthogonal reactions made it possible to visualize and study biomolecules in their native cellular context and contributed to advanced targeted drug delivery strategies. In our research group we are interested in developing novel bioorthogonal chemistry and apply this in the targeting of specific cell types. We recently added non-strained, highly soluble and stable vinylboronic acids (VBA) as reactants to the bioorthogonal toolbox which react with tetrazines in an inverse-electron demand Diels-Alder reaction. We have observed exceptional high reaction rates between non-strained vinylboronic acids (VBAs) and dipyridyl tetrazines relative to that of tetrazines lacking such dative coordinating ligand. As VBAs are mild Lewis acids, we hypothesize that coordination of the pyridyl to the boronic acid promotes the tetrazine ligation. In the current presentation, we explore the scope and molecular origins of the observed VBA ...
http://talks.cam.ac.uk/talk/index/122671
Nomination Summary for Propargyl alcohol (N96043)Nomination Summary for Propargyl alcohol (N96043)
Nominated Substances: Propargyl alcohol. Nomination Date: 09/20/1996 Nominator: NCI Rationale: Propargyl alcohol is nominated for subchronic studies based on potential for human exposure and a suspicion of carcinogenicity. Propargyl alcohol is a high production volume chemical which is used mainly as a chemical intermediate for a variety of products. It has been identified in air, soil and solid waste. The suspicion of carcinogenicity is based on its metabolism to the aldehyde and positive results in genotoxicity studies. The hepatotoxicity observed in previous studies is similar to that produced by carbon tetrachloride. Chronic toxicity data is lacking. NTP Principles: 1, 2, 7. ...
https://ntp.niehs.nih.gov/getinvolved/nominate/summary/nm-n96043.html
Nickel-Catalyzed Coupling of Carbonyl Compounds and Alkynes or 1 3-Dienes An Efficient Method for the Preparation of...Nickel-Catalyzed Coupling of Carbonyl Compounds and Alkynes or 1 3-Dienes An Efficient Method for the Preparation of...
Highlights Ni-Catalyzed Coupling Reactions Nickel-Catalyzed Coupling of Carbonyl Compounds and Alkynes or 1,3-Dienes: An Efficient Method for the Preparation of Allylic, Homoallylic, and Bishomoallylic Alcohols Shin-ichi Ikeda* Keywords: alcohols · C C coupling · catalysis · multicomponent reactions · nickel The alkenylation, allylation, and homoallylation of carbonyl compounds, which gives allylic, homoallylic, and bishomoallylic alcohols, respectively, are important processes in the formation of carbon-carbon bonds. However, in these approaches, the preparation of the corresponding alkenylating, allylating, and homoallylating reagents, which often requires troublesome procedures, is unavoidable.[1-5] Recently, new nickelcatalyzed coupling reactions of a carbonyl compound (e.g., aldehyde or ketone) and an unsaturated substrate (e.g., alkyne or 1,3-diene) with an organometallic or metal hydride have been reported, and these offer more efficient methods to give the desired alcohols without ...
https://www.docme.ru/doc/1949227/nickel-catalyzed-coupling-of-carbonyl-compounds-and-alkyn..
Visible-light-mediated dehydrogenative cross-coupling between terminal alkynes and aldehydes by employing a supramolecular...Visible-light-mediated dehydrogenative cross-coupling between terminal alkynes and aldehydes by employing a supramolecular...
Kataria, Meenal ; Deol, Harnimarta ; Singh, Gurpreet ; Kumar, Manoj ; Bhalla, Vandana (2018) Visible-light-mediated dehydrogenative cross-coupling between terminal alkynes and aldehydes by employing a supramolecular polymeric ensemble of PBI derivative New Journal of Chemistry, 42 (2). pp. 822-826. ISSN 1144-0546 Full text not available from this repository.. Official URL: http://pubs.rsc.org/en/content/articlelanding/2018.... Related URL: http://dx.doi.org/10.1039/C7NJ03557H ...
http://repository.ias.ac.in/114443/
Isolated, well-defined organovanadium(III) on silica: Single-site catalyst for hydrogenation of alkenes and alkynes<...
TY - JOUR. T1 - Isolated, well-defined organovanadium(III) on silica. T2 - Single-site catalyst for hydrogenation of alkenes and alkynes. AU - Sohn, H.. AU - Camacho-Bunquin, J.. AU - Langeslay, R. R.. AU - Ignacio-De Leon, P. A.. AU - Niklas, J.. AU - Poluektov, O. G.. AU - Liu, C.. AU - Connell, J. G.. AU - Yang, D.. AU - Kropf, J.. AU - Kim, H.. AU - Stair, P. C.. AU - Ferrandon, M.. AU - Delferro, M.. PY - 2017/1/1. Y1 - 2017/1/1. N2 - A well-defined, isolated, single-site organovanadium(iii) catalyst on SiO2 [(SiO2)V(Mes)(THF)] was synthesized via surface organometallic chemistry, and fully characterized using a combination of analytical and spectroscopic techniques (EA, ICP, 1H NMR, TGA-MS, EPR, XPS, DR-UV/Vis, UV-Raman, DRIFTS, XAS). The catalyst exhibits unprecedented reactivity in liquid-and gas-phase alkene/alkyne hydrogenation. Kinetic poisoning experiments revealed that 100% of the V sites are active for hydrogenation.. AB - A well-defined, isolated, single-site organovanadium(iii) ...
https://sofi-northwestern.pure.elsevier.com/en/publications/isolated-well-defined-organovanadiumiii-on-silica-single-site-cat
Alkyne nomenclature | Alkenes and Alkynes | Organic chemistry | Khan Academy
Rules for naming alkynes (molecules with a carbon-carbon triple bond). Created by Jay. Watch the next lesson: https://www.khanacademy.org/science/organic-chemistry/alkenes-alkynes/naming-preparation-alkynes/v/alkyne-acidity-and-alkylation?utm_source=YT&utm;_medium=Desc&utm;_campaign=organicchemistry Missed the previous lesson? https://www.khanacademy.org/science/organic-chemistry/alkenes-alkynes/alkene-reactions-tutorial/v/ozonolysis-1?utm_source=YT&utm;_medium=Desc&utm;_campaign=organicchemistry Organic Chemistry on Khan Academy: Carbon can form covalent bonds with itself and other elements to create a mind-boggling array of structures. In organic chemistry, we will learn about the reactions chemists use to synthesize crazy carbon based structures, as well as the analytical methods to characterize them. We will also think about how those reactions are occurring on a molecular level with reaction mechanisms. Simply put, organic chemistry is like building with molecular Legos. Lets make some
https://curiosity.com/videos/alkyne-nomenclature-or-alkenes-and-alkynes-or-organic-chemistry-or-khan-academy-khan-academy
POLYCYCLIC AROMATIC RING SYNTHESIS USING PALLADIUM CATALYZED C-H ACTIVATION AND ENAMINE-CATALYZED [3+2] CYCLOADDITION REACTIONS...POLYCYCLIC AROMATIC RING SYNTHESIS USING PALLADIUM CATALYZED C-H ACTIVATION AND ENAMINE-CATALYZED [3+2] CYCLOADDITION REACTIONS...
Huge advances have been made in the field of palladium catalyzed C-H activation in the past decade. The application of palladium catalyzed C-H activation to form complex, multifunctional substrates, especially directly C-H alkynylation are positively exploring. We have recently successfully elucidated a series of palladium catalyzed C-H alkynylation from commercial available material. These transformations included synthesis of highly substituted cyclopentadiene fused chromones from cascade reactions of coumarins with alkynes and C¿H/N¿H dual activation to synthesize benzazepines from isatin and alkynes; Recent years have witnessed an explosive growth in the field of iminium and enamine catalysis. Primary and secondary amines as catalysis in the cycloaddition transformation of biological and pharmaceutical compounds via the iminmium activation model have been greatly explored. We have successfully explored a series of enamine catalyzed [3+2] cycloaddition. These pioneering works consisted by ...
http://scholarbank.nus.edu.sg/handle/10635/38751
Sonogashira coupling - WikipediaSonogashira coupling - Wikipedia
The Sonogashira reaction is a cross-coupling reaction used in organic synthesis to form carbon-carbon bonds. It employs a palladium catalyst to form a carbon-carbon bond between a terminal alkyne and an aryl or vinyl halide. R − ≡ − H + R ′ − X → base, rt Pd cat., Cu cat. R − ≡ − R ′ {\displaystyle {\begin{matrix}{}\\{\ce {R-\!{\equiv }\!-H}}+{\color {Red}{\ce {R}}}\!-\!{\ce {X->[{\text{Pd cat., Cu cat.}}][{\text{base, rt}}]R-\!{\equiv }\!}}{\color {Red}{\ce {-R}}}\end{matrix}}} R: Aryl or Vinyl X: I, Br, Cl or OTf The Sonogashira cross-coupling reaction has been employed in a wide variety of areas, due to its usefulness in the formation of carbon-carbon bonds. The reaction can be carried out under mild conditions, such as at room temperature, in aqueous media, and with a mild base, which has allowed for the use of the Sonogashira cross-coupling reaction in the synthesis of complex molecules. Its applications include pharmaceuticals, natural products, organic materials, ...
https://en.wikipedia.org/wiki/Sonogashira_coupling
Sonogashira coupling
The Sonogashira reaction is a cross-coupling reaction used in organic synthesis to form carbon-carbon bonds . It employs a palladium catalyst to form a carbon-carbon bond between a terminal alkyne and an aryl or vinyl halide . The Sonogashira cross-coupling reaction has been employed in a wide variety of areas, due to its usefulness in the formation of carbon-carbon bonds. The reaction can be carried out under mild conditions, such as at room temperature, in aqueous media, and with a mild base, which has allowed for the use of the Sonogashira cross-coupling reaction in the synthesis of complex molecules. Its applications include pharmaceuticals, natural products, organic materials, and nanomaterials. Specific examples include its use in the synthesis of tazarotene , which is a treatment for psoriasis and acne , and in the preparation of SIB-1508Y, also known as Altinicline , which is a potential treatment for Parkinson's disease , Alzheimer's disease , Tourette syndrome , schizophrenia ,
https://www.revolvy.com/topic/Sonogashira+coupling
中国科学院上海有机化学研究所机构知识库(SIOC OpenIR): Ruthenium-catalyzed 1,3-dipolar cycloaddition of trifluoromethylated propargylic alcohols...
The 1,3-dipolar cycloaddition of trifluoromethylated propargylic alcohols 1 with azides in the presence of catalytic [Cp*RuCl2], afforded exclusively 4-trifluoroniethyl-1,4,5-trisubstituted-1,2,3-triazoles 2 in high yields. (c) 2008 Elsevier Ltd. All rights reserved ...
http://ir.sioc.ac.cn/handle/331003/17641
Ligand-Promoted, Copper Nanoparticles Catalyzed Oxidation of Propargylic Alcohols with TBHP or Air as OxidantLigand-Promoted, Copper Nanoparticles Catalyzed Oxidation of Propargylic Alcohols with TBHP or Air as Oxidant
see article for more reactions. Abstract. A highly efficient oxidation of propargylic alcohols to ynones is catalyzed by copper nanoparticles (Cu Nps) with TBHP or air as oxidants. With bipyridine as the ligand, the reaction was accelerated significantly and led in good to excellent yields to a variety of propargylic alcohols.. ...
http://www.organic-chemistry.org/abstracts/lit3/413.shtm
中国科学院大连化学物理研究所机构知识库(DICP OpenIR): Iridium- and Rhodium-Catalyzed C-H Activation and Formyl Alkynylation of Benzaldehydes under...
Mild and efficient synthesis of ynones via Ir(III)- and Rh(III)-catalyzed, chelation-assisted formyl C-H alkynylation of benzaldehydes has been achieved using hypervalent iodine-alkyne reagents. Rhodium and iridium catalysis exhibited complementary substrate scope ...
http://cas-ir.dicp.ac.cn/handle/321008/146044
Synthesis of Imidazole-Derived Ionic Liquids from Monoterpenes by Means of the Sonogashira Reaction | Marcelo Speziali
Speziali MG, Monteiro AL. Synthesis of Imidazole-Derived Ionic Liquids from Monoterpenes by Means of the Sonogashira Reaction. Synthesis-StuttgartSynthesis-StuttgartSynthesis-Stuttgart. 2012;44:3505-3511.
http://professor.ufop.br/marcelo/publications/synthesis-imidazole-derived-ionic-liquids-monoterpenes-means-sonogashira
New digold catalysts yield enantiopure cyclobutenesNew digold catalysts yield enantiopure cyclobutenes
Prof. Echavarrens group presents the first general enantioselective synthesis of cyclobutenes by intermolecular [2+2] cycloadditions. Digold complexes catalyse the reaction between terminal alkynes and alkenes leading to chiral cyclobutenes, useful in organic chemistry because they can be hydrogenated into functionalised cyclobutanes, which are motifs present in a variety of natural products and pharmaceuticals.. Previous attempts to achieve this transformation required activated alkynes or strained alkenes. The new strategy developed at ICIQ works for an enormous variety of terminal alkynes and a myriad of both disubstituted and trisubstituted alkenes. In total, this gold-catalysed reaction was used to synthesize a scope of over 40 different products, all with good yields and excellent enantiomeric ratios.. Due to the linear geometry of gold(I) complexes, chiral ligands are usually far away from the reaction centre. Hence, finding the gold catalysts that yield enantioselective transformations ...
http://www.iciq.org/new-digold-catalysts-yield-enantiopure-cyclobutenes/
Publications 2007
M. Konkol, H. Schmidt, D. Steinborn, J. Mol. Catal. A: Chemical 2007, 261, 301 - 305. „Iridium-catalyzed addition of methanol to internal alkynes. ___________________________________________________________. M. Konkol, H. Schmidt, D. Steinborn, J. Mol. Catal. A: Chemical 2007, 269, 119 - 124. „Iridium-catalyzed addition of methanol to terminal alkynes ___________________________________________________________. M. Vavra, I. Potočň k, M. Dušek, K. Fejfarov , C. Wagner, D. Steinborn, Achievements in Coordination, Bioinorganic and Applied Inorganic Chemistry (Eds. M. Melnik, J. ima, M. Tatarko), STU Press, Bratislava, 2007, 333 - 344 ...
http://www.chemie.uni-halle.de/bereiche_der_chemie/anorganische_chemie/ak_steinborn/1788187_1788214/1788214_1788993/?lang=en
A minireview of hydroamination catalysis: alkene and alkyne substrate selective, metal complex design | BMC Chemistry | Full...A minireview of hydroamination catalysis: alkene and alkyne substrate selective, metal complex design | BMC Chemistry | Full...
Organic compounds that contain nitrogen are very important intermediates in pharmaceutical and chemical industry. Hydroamination is the reaction that can form C-N bond with high atom economy. The research progress in metals catalyzed hydroamination of alkenes and alkynes from the perspective of reaction mechanism is categorized and summarized.
https://bmcchem.biomedcentral.com/articles/10.1186/s13065-019-0606-7/schemes/19
Synthesis of Natural Product-like Polyheterocycles via One-Pot Cascade Oximation, C-H Activation, and Alkyne Annulation - ...Synthesis of Natural Product-like Polyheterocycles via One-Pot Cascade Oximation, C-H Activation, and Alkyne Annulation - ...
Mentioning: 12 - An efficient protocol for the direct transformation of chroman-4-ones to tricyclic fused pyridines with the skeleton of cassiarins, a family of alkaloids with antimalarial activity, was developed. Also, a general strategy for modular construction of polyheterocycles with diverse natural product-like skeletons was developed by using ketone-alkyne bifunctional substrates. These reactions involved a one-pot cascade oximation of ketones, rhodium-catalyzed C-H activation, and intermolecular/intramolecular alkyne annulations under mild conditions with high atom, step, and redox economy.
https://scite.ai/reports/synthesis-of-natural-product-like-polyheterocycles-Ozp114
Alkyl Bromides as Mild Hydride Sources in Ni-Catalyzed Hydroamidation of Alkynes with IsocyanatesAlkyl Bromides as Mild Hydride Sources in Ni-Catalyzed Hydroamidation of Alkynes with Isocyanates
A catalytic hydroamidation of alkynes with isocyanates using alkyl bromides as hydride sources has been developed. The method turns parasitic β-hydride elimination into a strategic advantage, rapidly affording acrylamides with excellent chemo- and regioselectivity.. ...
http://www.iciq.org/research/publication/alkyl-bromides-as-mild-hydride-sources-in-ni-catalyzed-hydroamidation-of-alkynes-with-isocyanates/
Amidate complexes of titanium and zirconium: a new class of tunable precatalysts for the hydroamination of alkynes | UBC...Amidate complexes of titanium and zirconium: a new class of tunable precatalysts for the hydroamination of alkynes | UBC...
A series of bis(amidate)group 4-bis(amido) complexes have been prepared, characterized and have been shown to be highly tunable precatalysts for both the intra- and intermolecular hydroamination of alkynes.. ...
https://chem.ubc.ca/amidate-complexes-titanium-and-zirconium-new-class-tunable-precatalysts-hydroamination-alkynes
Naphthoquinones from alkynes and chromium-carbene complexes-control of regioselectivity through intramolecular reaction<...Naphthoquinones from alkynes and chromium-carbene complexes-control of regioselectivity through intramolecular reaction<...
TY - JOUR. T1 - Naphthoquinones from alkynes and chromium-carbene complexes-control of regioselectivity through intramolecular reaction. AU - Semmelhack, Martin F.. AU - Bozell, Joseph J.. PY - 1982/1/1. Y1 - 1982/1/1. N2 - A series of carbene-chromium complexes bearing a phenyl substituent and an alkoxy-alkyne substituent have been prepared by acetoxy replacement. Intramolecular cycloaddition with carbon monoxide insertion occurs to provide naphthohydroquinones in good yield.. AB - A series of carbene-chromium complexes bearing a phenyl substituent and an alkoxy-alkyne substituent have been prepared by acetoxy replacement. Intramolecular cycloaddition with carbon monoxide insertion occurs to provide naphthohydroquinones in good yield.. UR - http://www.scopus.com/inward/record.url?scp=0000695788&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0000695788&partnerID=8YFLogxK. U2 - 10.1016/S0040-4039(00)87497-3. DO - 10.1016/S0040-4039(00)87497-3. M3 - Article. AN - ...
https://collaborate.princeton.edu/en/publications/naphthoquinones-from-alkynes-and-chromium-carbene-complexes-contr
Post Modification of Acetylene Functional Poly(oxindole biphenylylene) by Photoinduced CuAAC - KAUST RepositoryPost Modification of Acetylene Functional Poly(oxindole biphenylylene) by Photoinduced CuAAC - KAUST Repository
A novel strategy to obtain side chain modified poly(oxindole biphenylylene) (POXI) by photoinduced copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) click reaction is described. In the first step, an alkyne-functionalized poly(oxindolebiphenylylene) (POXI-alkyne) is synthesized by superacid-catalyzed condensation of isatin with aromatic hydrocarbons. Subsequently, poly(ethylene glycol) methyl ether (Me-PEG), 1-pyrenemethanol (Py-OH) and 1,3-dibromopropane (DBP) are functionalized by azide groups via simple nucleophilic substitution reaction. Visible-light-induced CuAAC reaction between POXI-alkyne and the corresponding azide functionalized click components employing dibenzoyldiethylgermane (DBDEG) as photoactivator resulted in the formation of POXI-PEG, POXI-Py and insoluble network, respectively. Successful modification of POXI was confirmed by the spectral, (1H NMR, FT-IR, Fluorescence), chromatographic (GPC) and thermal (DSC) investigations ...
http://repository.kaust.edu.sa/kaust/handle/10754/627125
On-Surface Azide-Alkyne Cycloaddition on Cu(111): Does It Click in Ultrahigh Vacuum? - Danish National Research Database-Den...On-Surface Azide-Alkyne Cycloaddition on Cu(111): Does It Click in Ultrahigh Vacuum? - Danish National Research Database-Den...
Interdisciplinary Nanoscience Center - INANO-Fysik, iNANO-huset, Interdisciplinary Nanoscience Center, Science and Technology, Aarhus ...
http://www.forskningsdatabasen.dk/catalog/236149213
Precise grafting of macrocyclics and dendrons to a linear polymer chain<...
TY - JOUR. T1 - Precise grafting of macrocyclics and dendrons to a linear polymer chain. AU - Amir, Faheem. AU - Hossain, Md D.. AU - Jia, Zhongfan. AU - Monteiro, Michael J.. PY - 2016/8/31. Y1 - 2016/8/31. N2 - Sequential growth of multifunctional telechelic polymer chains was used here to produce three, four or seven HO-functionalities equally spaced along the polymer backbone. The telechelic building block consisted of a halide group on one end and both a hydroxyl and alkyne group on the other end. The key was to maintain the halide end-group on the telechelic polymer chain during the CuAAC coupling reaction after each sequential growth. This was accomplished by using the combination of the PMDETA ligand and toluene as a solvent to produce significantly faster rates of CuAAC coupling reaction over halide abstraction. The HO-functionalities were then converted to azide groups allowing further CuAAC reactions with either alkyne polymeric dendrons or cyclics to produce equally spaced grafts ...
https://researchnow.flinders.edu.au/en/publications/precise-grafting-of-macrocyclics-and-dendrons-to-a-linear-polymer
Notes and Important Points on Alkanes, Alkenes and Alkynes - Chemistry - KCET EngineeringNotes and Important Points on Alkanes, Alkenes and Alkynes - Chemistry - KCET Engineering
Free Notes on Alkanes, Alkenes and Alkynes - KCET Engineering. Read all the Important points and Chapterwise Notes on KCET Engineering
https://www.simplylearnt.com/notes/Alkanes--Alkenes-and-Alkynes-7
Effect of heteroatom on tandem cycloaddition-Cycloreversion of 2-pyrone and 1,4-oxazinone with hetero alkynes: A DFT explorationEffect of heteroatom on tandem cycloaddition-Cycloreversion of 2-pyrone and 1,4-oxazinone with hetero alkynes: A DFT exploration
Reactions of 2-pyrone (2P) and 1,4-oxazinone (OXZ) with hetero alkynes viz., phosphines (HA1) and silanes (HA2) have been scanned at B3LYP/6-31G(d) level.
http://www.chemistryjournal.in/archives/2018/vol2/issue5/2-6-15
H CC 9.5 Acidity of Acetylene and Terminal Alkynes. - ppt downloadH CC 9.5 Acidity of Acetylene and Terminal Alkynes. - ppt download
Acetylene is a weak acid, but not nearly as weak as alkanes or alkenes. CompoundpK a HF3.2 H 2 O16 NH CH 4 60 H2CH2CH2CH2C CH 2 HCCH 26 Acetylene
http://slideplayer.com/slide/4385380/
dPEG® Compounds from Quanta Biodesign - PEGylation | Sigma-AldrichdPEG® Compounds from Quanta Biodesign - PEGylation | Sigma-Aldrich
These are dPEG® compounds from Quanta Biodesign that contain discrete length PEGs. This can improve reproducibility in experiments when compared to using PEGs of variable length. PEGS have high aqueous solubility and a substances aqueous solubility can be improved by attaching a PEG. Some of these compounds contain a single reactive end for attachment to proteins such as through amines or sulfhydryls. This list includes branched PEGs which are more compact than long linear PEGs. There are also compounds with two reactive ends for crosslinking. Some of the compounds have azide groups which can be attached to alkynes using copper click chemistry or to strained alkynes through copper-free click chemistry. Some of the compounds have a biotin on one end for capture by avidins. Overall the many options offered by these dPEG® products can enable a variety of biconjugation applications.
https://www.sigmaaldrich.com/chemistry/chemistry-products.html?TablePage=122064803
New Synthetic routes towards constrained cyclic peptides inspired by vancomycinNew Synthetic routes towards constrained cyclic peptides inspired by vancomycin
Vancomycin is the last resort antibiotic against MRSA. Vancomycin causes the bacteria to die by physically blocking a recognition site within the cell wall. This recognition site binds to the inner cavity of vancomycin, which consists of a rigid bicyclic structure. The objective of my research was to mimic this ... read more bicyclic structure using synthetic alkene and alkyne bridges, and to see if a similar cavity was obtained. The alkene bridges were introduced using a (tandem) ring-closing metathesis reaction and the alkyne bridges were introduced by a Sonogashira reaction. show less ...
https://dspace.library.uu.nl/handle/1874/19143
Ionic Liquid Iodinating Reagent for Mild and Efficient Iodination of Aromatic and Heteroaromatic Amines and Terminal AlkynesIonic Liquid Iodinating Reagent for Mild and Efficient Iodination of Aromatic and Heteroaromatic Amines and Terminal Alkynes
A free platform for explaining your research in plain language, and managing how you communicate around it - so you can understand how best to increase its impact.
https://www.growkudos.com/publications/10.1080%25252F00397911.2012.749991/reader
Molecules | Free Full-Text | Peptide Conjugation via CuAAC Click ChemistryMolecules | Free Full-Text | Peptide Conjugation via CuAAC Click Chemistry
The copper (I)-catalyzed alkyne azide 1,3-dipolar cycloaddition (CuAAC) or click reaction, is a highly versatile reaction that can be performed under a variety of reaction conditions including various solvents, a wide pH and temperature range, and using different copper sources, with or without additional ligands or reducing agents. This reaction is highly selective and can be performed in the presence of other functional moieties. The flexibility and selectivity has resulted in growing interest in the application of CuAAC in various fields. In this review, we briefly describe the importance of the structural folding of peptides and proteins and how the 1,4-disubstituted triazole product of the CuAAC reaction is a suitable isoster for an amide bond. However the major focus of the review is the application of this reaction to produce peptide conjugates for tagging and targeting purpose, linkers for multifunctional biomacromolecules, and reporter ions for peptide and protein analysis.
http://mdpi.com/1420-3049/18/11/13148
Multiarm Star Block Copolymers via Diels-Alder Click Reaction | AVESİSMultiarm Star Block Copolymers via Diels-Alder Click Reaction | AVESİS
Two types of multiarm star block copolymers: (polystyrene)(m)-poly(divinylbenzene)-poly(methyl methacrylate)(n), (PS)(m),-polyDVB-(PMMA)(n) and (polystyrene)(m)-poly(divinylbenzene)-poly(tert-butyl acrylate)(k), (PS)(m)-polyDVB-(PtBA)(k) were successfully prepared via a combination of cross-linking and Diels-Alder click reactions based on arm-first methodology. For this purpose, multiarm star polymer with anthracene functionality as reactive periphery groups was prepared by a cross-linking reaction of divinyl benzene using a-anthracene end functionalized polystyrene (PSAnth) as a macroinitiator. Thus, obtained multiarm star polymer was then reacted with furan protected maleimide-end functionalized polymers: PMMA-MI or PtBA-MI at reflux temperature of toluene for 48 h resulting in the corresponding multiarm, star block copolymers via Diels-Alder click reaction. The multiarm star and multiarm star block copolymers were characterized by using H-1 NMR, SEC, Viscotek triple detection SEC (TD-SEC) ...
https://avesis.bezmialem.edu.tr/yayin/ecca41c6-78f8-49a3-b502-a607d85ff0d7/multiarm-star-block-copolymers-via-diels-alder-click-reaction
Download Click reactions in organic synthesis by Srinivasan Chandrasekaran PDF - Choosing Exellence E-books
0)non-5-ene (DBN). 14). 14 Tertiary-amine-catalyzed thiol-isocyanate click reaction. 3 Thiol-Michael Addition Click Reactions Hydrothiolation of C==C double bond can be performed in the presence of mild bases or using nucleophilic catalysis. Unlike thiol-ene radical reaction (which can proceed with almost all olefins), thiol Michael addition reactions require activated carbon-carbon double bonds, which are in conjugation with an EWG. In the presence of trialkylamine bases such as NEt3 , the reaction proceeds smoothly to give the addition products in very high yields. This family includes 15 isoenzymes (I-XIV, V further subclassified as VA and VB) endowed with different molecular features, cellular localization, distribution in organs and tissues, and kinetic properties. It has been demonstrated that the dysfunction of these enzymes is related to different pathologies such as cancer (CAs VII, IX, XII), neurodegeneration (CA VIII), obesity (CAs VA and VB), and sterility (CA XIII) [36]. 3). 76) ...
http://choosingexcellence.org/library/click-reactions-in-organic-synthesis
Rearrangement of indene skeletons under mild conditions<...
TY - JOUR. T1 - Rearrangement of indene skeletons under mild conditions. AU - Kuninobu, Yoichiro. AU - Ueda, Hirokazu. AU - Kawata, Atsushi. AU - Takai, Kazuhiko. PY - 2007/8/31. Y1 - 2007/8/31. N2 - (Chemical Equation Presented) Isomerization between two isomers of 1,2-disubstituted 3-aminoindenes occurs via the rearrangement of indene frameworks. In contrast to previous rearrangements of indene derivatives, which occur under high-temperature conditions or the irradiation of light, this rearrangement proceeds at room temperature without UV light irradiation. An amino group at the 3-position plays an important role to accelerate the rearrangement under mild conditions.. AB - (Chemical Equation Presented) Isomerization between two isomers of 1,2-disubstituted 3-aminoindenes occurs via the rearrangement of indene frameworks. In contrast to previous rearrangements of indene derivatives, which occur under high-temperature conditions or the irradiation of light, this rearrangement proceeds at room ...
https://okayama.pure.elsevier.com/en/publications/rearrangement-of-indene-skeletons-under-mild-conditions
IJMS | Free Full-Text | A Versatile Chemo-Enzymatic Conjugation Approach Yields Homogeneous and Highly Potent Antibody-Drug...IJMS | Free Full-Text | A Versatile Chemo-Enzymatic Conjugation Approach Yields Homogeneous and Highly Potent Antibody-Drug...
The therapeutic efficacy of antibodies can be successfully improved through targeted delivery of potent cytotoxic drugs in the form of antibody-drug conjugates. However, conventional conjugation strategies lead to heterogeneous conjugates with undefined stoichiometry and sites, even with considerable batch-to-batch variability. In this study, we have developed a chemo-enzymatic strategy by equipping the C-terminus of anti-CD20 ofatumumab with a click handle using Sortase A, followed by ligation of the payload based on a strain-promoted azide-alkyne cycloaddition to produce homogeneous conjugates. The resulting antibody-drug conjugates fully retained their antigen binding capability and proved to be internalized and trafficked to the lysosome, which released the payload with a favorable efficacy in vitro and in vivo. Thus, this reported method is a versatile tool with maximum flexibility for development of antibody-drug conjugates and protein modification.
http://www.mdpi.com/1422-0067/18/11/2284
N-Myristoyl Transferase (NMT)-Catalyzed Labeling of Bacterial Proteins for Imaging in Fixed and Live Cells - CaltechAUTHORSN-Myristoyl Transferase (NMT)-Catalyzed Labeling of Bacterial Proteins for Imaging in Fixed and Live Cells - CaltechAUTHORS
Methods for selective protein imaging are critical for elucidating how cells orchestrate fundamental biological processes. We recently developed a chemoenzymatic method to modify bacterial proteins in situ for fluorescence imaging using N-myristoyl transferase (NMT). Target proteins outfitted with an N-terminal NMT recognition sequence are covalently modified with an azido fatty acid. Subsequent strain-promoted azide-alkyne cycloaddition allows for conjugation to cell-permeant fluorophores and imaging by fluorescence microscopy. Here we describe sample preparation and labeling protocols for imaging bacterial proteins in fixed and live cells. ...
https://authors.library.caltech.edu/96228/
SYNTHESIZING IDEAS: Click Chemistry for Pyrrole SynthesisSYNTHESIZING IDEAS: Click Chemistry for Pyrrole Synthesis
Prof. Aiwen Lei and coworkers, Wuhan University, Hubei, have developed a silver catalyst click reaction for the synthesis of pyrrole, by cycloaddition. This system benefits from readily-available starting materials, low catalyst loading (0.1 eq), short reaction times (2 h) and excellent chemo-selectivity. And, works for both internal and alkyl substituted terminal alkynes in the presence of many functional groups. The extremely mild conditions used, makes this reaction synthetically attractive ...
http://syntheticorganic.blogspot.com/2013/05/click-chemistry-for-pyrrole-synthesis.html
RADIOLABELLING METHODS - Patent applicationRADIOLABELLING METHODS - Patent application
0018] Compounds of formula (I) and (III) wherein the vector is a peptide or protein may be prepared by standard methods of peptide synthesis, for example, solid-phase peptide synthesis, for example, as described in Atherton, E. and Sheppard, R. C.; Solid Phase Synthesis; IRL Press: Oxford, 1989. Incorporation of the alkyne or azide group in a compound of formula (I) or (III) may be achieved by reaction of the N or C-terminus of the peptide or with some other functional group contained within the peptide sequence, modification of which does not affect the binding characteristics of the vector. The alkyne or azide groups are preferably introduced to a compound of formula (I) or (III) by formation of a stable amide bond, for example formed by reaction of a peptide amine function with an activated acid or alternatively reaction of a peptide acid function with an amine function and introduced either during or following the peptide synthesis. Methods for incorporation of the alkyne or azide group ...
http://www.patentsencyclopedia.com/app/20110236311
AlkyneAlkyne
Alkynes form complexes with transition metals. Such complexes occur also in metal catalyzed reactions of alkynes such as alkyne ... Look up alkyne in Wiktionary, the free dictionary. Wikiquote has quotations related to Alkyne. -yne cycloalkyne Alkyne. ... Cycloaddition processes involving alkynes are often catalyzed by metals, e.g. enyne metathesis and alkyne metathesis, which ... Electrophilic alkynes are especially effective dienophiles. The "cycloadduct" derived from the addition of alkynes to 2-pyrone ...
https://en.wikipedia.org/wiki/Alkyne
Alkyne trimerisationAlkyne trimerisation
Alkyne trimerization is of no practical value, although the reaction was highly influential. The cotrimerization of alkynes and ... In organic chemistry, an alkyne trimerisation is a [2+2+2] cycloaddition reaction in which three alkyne units (C≡C) react to ... In terms of mechanism, the reactions begin with the formation of metal-alkyne complexes. The combination of two alkynes within ... Many variations have been developed, including cyclisation of mixtures of alkynes and alkenes as well as alkynes and nitriles. ...
https://en.wikipedia.org/wiki/Alkyne_trimerisation
Alkyne metathesisAlkyne metathesis
... can be used in ring-closing operations and RCAM stands for ring closing alkyne metathesis. The olfactory ... Alkyne metathesis is an organic reaction that entails the redistribution of alkyne chemical bonds. The reaction requires metal ... Catalysts for alkyne metathesis "canopy catalysts" Air stable low-valent d2 rhenium alkylidyne various Schrock-based alkyne ... Ritter, S. (March 26, 2007). "Nitrile-Alkyne Cross-Metathesis". Chemical & Engineering News. Alkyne Metathesis in Organic ...
https://en.wikipedia.org/wiki/Alkyne_metathesis
Alkyne zipper reactionAlkyne zipper reaction
The alkyne zipper reaction is an organic reaction that involves isomerization of a non terminal alkyne into a terminal alkyne. ... essentially moving the alkyne along the alkane chain until a terminal alkyne is achieved. Once a terminal alkyne is achieved, ... 8, p. 146 "Alkyne Zipper Reaction". SynArchive. 2017. Archived from the original on 2011. Retrieved December 19, 2017. ( ... The conversion provides a useful approach for remote functionalization in long-chain alkynes. The reaction requires a strong ...
https://en.wikipedia.org/wiki/Alkyne_zipper_reaction
Transition metal alkyne complexTransition metal alkyne complex
... es are often formed by the displacement of labile ligands by the alkyne. For example, a variety ... This kind of bonding was first implicated in complexes of the type W(CO)(R2C2)3. Because alkynes have two π bonds, alkynes can ... Metal alkyne complexes are intermediates in the semihydrogenation of alkynes to alkenes: C2R2 + H2 → cis-C2R2H2 This ... In organometallic chemistry, a transition metal alkyne complex is a coordination compound containing one or more alkyne ligands ...
https://en.wikipedia.org/wiki/Transition_metal_alkyne_complex
Azide-alkyne Huisgen cycloadditionAzide-alkyne Huisgen cycloaddition
The azide-alkyne Huisgen cycloaddition is a 1,3-dipolar cycloaddition between an azide and a terminal or internal alkyne to ... Unlike CuAAC in which only terminal alkynes reacted, in RuAAC both terminal and internal alkynes can participate in the ... While the copper(I)-catalyzed variant gives rise to a triazole from a terminal alkyne and an azide, formally it is not a 1,3- ... The copper (I) species generated in situ forms a pi complex with the triple bond of a terminal alkyne. In the presence of a ...
https://en.wikipedia.org/wiki/Azide-alkyne_Huisgen_cycloaddition
Marcey WatersMarcey Waters
"Mechanistic Studies on the Reaction of Fischer Carbene Complex with Alkynes: Does the Alkyne Insertion Intermediate Form ... and alkynes. Walters graduated from Chicago in 1997 with a PhD in chemistry. She was an NIH postdoctoral fellow in Prof. Ronald ...
https://en.wikipedia.org/wiki/Marcey_Waters
Unsaturated hydrocarbonUnsaturated hydrocarbon
"Hydration of Alkynes". Chem LibreTexts. May 2, 2019. Retrieved May 6, 2019. "Reactions of Alkynes - Addition of HX and X2". ... Alkynes, under metal catalysts, for example cobalt, can also go under cycloaddition reaction called alkyne trimerization. Three ... The DCD model can also describe the alkyne ligand structure. Metal complex can also be intermediate of trimerization of alkynes ... The hydrohalogenation of alkyne is much slower than the alkene. The reaction equation of HBr addition to ethene is: H2C=CH2 + ...
https://en.wikipedia.org/wiki/Unsaturated_hydrocarbon
Cis-trans isomerismCis-trans isomerism
Ouellette, Robert J.; Rawn, J. David (2015). "Alkenes and Alkynes". Principles of Organic Chemistry. pp. 95-132. doi:10.1016/ ... being the only isomer that can reduce alkenes and alkynes to alkanes, but for a different reason: the trans isomer cannot line ...
https://en.wikipedia.org/wiki/Cis–trans_isomerism
Thiol-yne reactionThiol-yne reaction
The thiol-yne reaction (also known as alkyne hydrothiolation) is an organic reaction between a thiol and an alkyne. The ... Diphenyl disulfide reacts with alkynes to a 1,2-bis(phenylthio)ethylene. Reported alkynes are ynamides. A photoredox thiol-yne ... Yadav, J. S.; Reddy, B. V. Subba; Raju, A.; Ravindar, K.; Baishya, Gakul (2007). "Hydrothiolation of Unactivated Alkynes ... Weiss, Charles J.; Wobser, Stephen D.; Marks, Tobin J. (2009). "Organoactinide-Mediated Hydrothiolation of Terminal Alkynes ...
https://en.wikipedia.org/wiki/Thiol-yne_reaction
EthynylEthynyl
Also sometimes designed as ethinyl in compounds (ethinylestradiol, ethisterone (ethinyltestosterone)). See main page alkynes. ...
https://en.wikipedia.org/wiki/Ethynyl
Favorskii reactionFavorskii reaction
This reaction is used to protect alkynes: the alkyne is either converted with acetone to a 2-hydroxyprop-2-yl-alkyne or a ... A metal acetylide is formed in situ when an alkyne is treated with a strong bases such as a hydroxide or an alkoxide: HC≡CH + ... 3.0.CO;2-R. Wuts, Peter G. M.; Greene, Theodora W. (2007). "Chapter 8. Protection for the Alkynes". Greene's Protective Groups ... The Favorskii reaction is an organic chemistry reaction between an alkyne and a carbonyl group, under basic conditions. The ...
https://en.wikipedia.org/wiki/Favorskii_reaction
KetoneKetone
By hydration of alkynes. Such processes occur via enols and require the presence of an acid and mercury(II) sulfate (HgSO4). ... This equilibrium allows ketones to be prepared via the hydration of alkynes. C−H bonds adjacent to the carbonyl in ketones are ... Ketones containing alkene and alkyne units are often called unsaturated ketones. The most widely used member of this class of ... This reaction always produces a ketone, even with a terminal alkyne, the only exception being the hydration of acetylene, which ...
https://en.wikipedia.org/wiki/Ketone
Glossary of engineering: A-LGlossary of engineering: A-L
Alkyne Is an unsaturated hydrocarbon containing at least one carbon-carbon triple bond. The simplest acyclic alkynes with only ... ISBN 978-1-4058-5345-3. Alkyne. Encyclopædia Britannica Callister, W. D. "Materials Science and Engineering: An Introduction" ...
https://en.wikipedia.org/wiki/Glossary_of_engineering:_A–L
Glossary of civil engineeringGlossary of civil engineering
alkyne In organic chemistry, an unsaturated hydrocarbon containing at least one carbon-carbon triple bond. alloy A combination ... ISBN 978-1-4058-5345-3. Alkyne. Encyclopædia Britannica Callister, W. D. "Materials Science and Engineering: An Introduction" ...
https://en.wikipedia.org/wiki/Glossary_of_civil_engineering
Organozirconium chemistryOrganozirconium chemistry
Substrates for hydrozirconation are alkenes and alkynes. Terminal alkynes give vinyl complexes. Secondary reactions are ...
https://en.wikipedia.org/wiki/Organozirconium_chemistry
CarbometalationCarbometalation
Trimethyl Silyl (TMS) protected alkynes, trimethyl germanium alkynes, and terminal alkynes can produce anti-carboalumination ... This zirconium cation can coordinate an alkene or alkyne where migratory insertion of a methyl then takes place. The resultant ... Carbometalations can be performed on alkynes and alkenes to form products with high geometric purity or enantioselectivity, ... Novel syntheses of .alpha.,.beta.-unsaturated cyclopentenones via allylzincation of alkynes". Journal of the American Chemical ...
https://en.wikipedia.org/wiki/Carbometalation
Organogold chemistryOrganogold chemistry
In 1991, Utimoto reacted gold(III) (NaAuCl4) with alkynes and water. Teles identified a major drawback of this method as Au(III ... Norman, R. O. C.; Parr, W. J. E.; Thomas, C. B. (1976). "The reactions of alkynes, cyclopropanes, and benzene derivatives with ... Cationic gold(I) forms π-complexes with alkene or alkyne bonds, following the Dewar-Chatt-Duncanson model. Gold is certainly ... For instance, Hashmi reported an AuCl3-catalyzed alkyne / furan Diels-Alder reaction - a type of cycloaddition that does not ...
https://en.wikipedia.org/wiki/Organogold_chemistry
OrganophosphineOrganophosphine
Similar reactions occur involving alkynes. Base is not required for electron-deficient alkenes (e.g., derivatives of ... "Nucleophilic and free-radical additions of phosphines and phosphine chalcogenides to alkenes and alkynes". Arkivoc. v (5): 12- ... acrylonitrile) and alkynes. Secondary (2°) phosphines, with the formula R2PH, are prepared analogously to the primary ...
https://en.wikipedia.org/wiki/Organophosphine
Seyferth-Gilbert homologationSeyferth-Gilbert homologation
The generation of nitrogen gas gives a vinyl carbene G, which via a 1,2-migration forms the desired alkyne H. The dimethyl ( ... A facile synthesis of alkynes". J. Org. Chem. 47 (10): 1837-1845. doi:10.1021/jo00349a007. D. G. Brown; E. J. Velthuisen; J. R ... S. Müller; B. Liepold; G. Roth & H. J. Bestmann (1996). "An Improved One-pot Procedure for the Synthesis of Alkynes from ... Reaction of Bestmann's reagent with aldehydes gives terminal alkynes often in very high yield and fewer steps than the Corey- ...
https://en.wikipedia.org/wiki/Seyferth–Gilbert_homologation
HydroaminationHydroamination
The four main categories are (1) nucleophilic attack on an alkene alkyne, or allyl ligand and (2) insertion of the alkene into ... Pohlki, F.; Doye, S. (2003). "The catalytic hydroamination of alkynes". Chem. Soc. Rev. 32: 104-114. doi:10.1039/b200386b. PMID ... Alonso, F.; Beletskaya, I.P.; Yus, M. (2004). "Transition-Metal-Catalyzed Addition of Heteroatom−Hydrogen Bonds to Alkynes". ... The unsaturated substrates that have been investigated include alkenes, dienes, alkynes, and allenes. For intramolecular ...
https://en.wikipedia.org/wiki/Hydroamination
Diphosphorus tetrafluorideDiphosphorus tetrafluoride
Other kinds of alkynes produced polymers with this treatment. With alkenes, similarly bis(difluorophosphino) is added across ... Under ultraviolet light diphosphorus tetrafluoride reacts with alkynes connected to trifluoromethyl groups to add ... "Photoreactions of tetrafluorodiphosphine with alkynes". Journal of Fluorine Chemistry. 40 (1): 41-49. doi:10.1016/S0022-1139(00 ...
https://en.wikipedia.org/wiki/Diphosphorus_tetrafluoride
Chloroplatinic acidChloroplatinic acid
Lewis, L. N.; Sy, K. G.; Bryant, G. L.; Donahue, P. E. (1991). "Platinum-catalyzed hydrosilylation of alkynes". Organometallics ...
https://en.wikipedia.org/wiki/Chloroplatinic_acid
Sonogashira couplingSonogashira coupling
Various aromatic alkynes can be employed to yield desired disubstituted products with satisfactorily yields. Aliphatic alkynes ... It is suggested that the presence of a base results in the formation of a π-alkyne complex E. This increases the acidity of the ... It employs a palladium catalyst as well as copper co-catalyst to form a carbon-carbon bond between a terminal alkyne and an ... Copper(I) salts, such as CuI, react with the terminal alkyne and produce a copper(I) acetylide, which acts as an activated ...
https://en.wikipedia.org/wiki/Sonogashira_coupling
HydrostannylationHydrostannylation
The typical Pd-based catalyst is tetrakis(triphenylphosphine)palladium(0). The typical unsaturated substrates are alkynes. The ...
https://en.wikipedia.org/wiki/Hydrostannylation
Zinc triflateZinc triflate
R. J. Rahaim & J. T. Shaw (2008). "Zinc-Catalyzed Silylation of Terminal Alkynes". J. Org. Chem. 73 (7): 2912-2915. doi:10.1021 ... "Silylation of 1-alkynes with chlorosilanes promoted by Zn(OTf)2: an efficient way to the preparation of alkynylsilanes". ...
https://en.wikipedia.org/wiki/Zinc_triflate
1-Decyne1-Decyne
It is a terminal alkyne. A colorless liquid, 1-decyne is used as a model substrate when evaluating methodology in organic ... Ishiyama, Tatsuo; Matsuda, Nobuo; Miyaura, Norio; Suzuki, Akira (1993). "Platinum(0)-Catalyzed Diboration of Alkynes". Journal ... of Azides and Terminal Alkynes". Angewandte Chemie International Edition. 41 (14): 2596-2599. doi:10.1002/1521-3773(20020715)41 ...
https://en.wikipedia.org/wiki/1-Decyne
BoroleBorole
The reaction with the electron-poor alkyne (C6F5)CC(C6F5) required rather harsh reaction conditions (110 °C, 7 days) and the ... In that study, 2 was reacted with three differently substituted alkynes that greatly differed in their electronic properties, ... towards alkynes in great detail. Of particular relevance was the question of whether the enhanced Lewis acidity of 2 compared 1 ... The potent Lewis acidity of 12 revealed a novel reaction pathway whereby the alkyne first adds to the borole nucleophilically, ...
https://en.wikipedia.org/wiki/Borole
IminoboraneIminoborane
Like alkynes, iminoboranes bind transition metals. Paetzold, Peter; Plotho, Christoph Von; Schmid, Günter; Boese, Roland; ...
https://en.wikipedia.org/wiki/Iminoborane
BicyclononyneBicyclononyne
September 2011). "Bioconjugation with strained alkenes and alkynes". Acc Chem Res. 44 (9): 805-15. doi:10.1021/ar200059z. PMID ...
https://en.wikipedia.org/wiki/Bicyclononyne
Gold(I)-Catalyzed Addition of Carboxylic Acids to AlkynesGold(I)-Catalyzed Addition of Carboxylic Acids to Alkynes
... Bathoju Chandra Chary and Sunggak Kim*. *Division of Chemistry and ... PPh3AuCl/AgPF6-catalyzed hydroacyloxylation of alkynes with carboxylic acids affords the Markonikov addition products, whereas ...
https://www.organic-chemistry.org/abstracts/lit3/094.shtm
Molecules | Free Full-Text | Structural Determinants of Alkyne Reactivity in Copper-Catalyzed Azide-Alkyne CycloadditionsMolecules | Free Full-Text | Structural Determinants of Alkyne Reactivity in Copper-Catalyzed Azide-Alkyne Cycloadditions
This work represents our initial effort in identifying azide/alkyne pairs for optimal reactivity in copper-catalyzed azide- ... alkyne cycloaddition (CuAAC) reactions. In previous works, we have identified chelating azides, in particular 2-picolyl azide, ... Choice of Alkynes. The tested alkynes are separated in three categories: (a) electron-withdrawing group-bearing alkynes (Figure ... Alkynes 20 and 21 were reexamined with the rest of alkynes at the original substrate concentrations (10 mM each for alkyne and ...
https://www.mdpi.com/1420-3049/21/12/1697/htm
Synthonix, Inc | AlkynesSynthonix, Inc | Alkynes
Intramolecular Coupling of Terminal Alkynes by Atom ManipulationIntramolecular Coupling of Terminal Alkynes by Atom Manipulation
... Author:. Albrecht, Florian. Rey Vieites, Dulce María. Fatayer ... We used voltage pulses from the tip to trigger a Glaser‐like coupling between terminal alkyne carbons within a custom‐ ... Glaser‐like coupling of terminal alkynes by thermal activation is extensively used in on‐surface chemistry. Here we demonstrate ...
https://minerva.usc.es/xmlui/handle/10347/24208
Tide Fluor™ 3 alkyne [TF3 alkyne] | SCBT - Santa Cruz BiotechnologyTide Fluor™ 3 alkyne [TF3 alkyne] | SCBT - Santa Cruz Biotechnology
TF3 alkyne], a biochemical for proteomics research, from Santa Cruz Biotechnology. , Molecular Weight: 495.57 ... Tide Fluor™ 3 alkyne [TF3 alkyne] *bvseo_sdk, java_sdk, bvseo-3.2.0 ... Tide Fluor™ 3 alkyne [TF3 alkyne] is a strong fluorescent dye used for labeling peptides and nucleotides. ...
https://www.scbt.com/sv/p/tide-fluor-3-alkyne-tf3-alkyne
Sulfo-Cy5-Alkyne, Alkyne-containing Fluorescent Dyes - Jena BioscienceSulfo-Cy5-Alkyne, Alkyne-containing Fluorescent Dyes - Jena Bioscience
Click Reagents by Chemistry Alkyne Reagents Fluorescent Dyes ... Sulfo-Cy5-Alkyne. Abs/Em = 647/663 nm. bis(Triethylammonium) ... You are here: Click Chemistry , Click Reagents by Chemistry , Alkyne Reagents , Fluorescent Dyes , Sulfo-Cy5-Alkyne ... Gutman et al. (2016) Biocompatible Azide-Alkyne "Click" Reactions for Surface Decoration of Glyco-Engineered Cells. Chembiochem ...
https://www.jenabioscience.com/click-chemistry/click-reagents-by-chemistry/alkyne-reagents/fluorescent-dyes/clk-ta116-sulfo-cy5-alkyne
Fluorination as tool to improve bioanalytical sensitivity and COX-2-selective antitumor activity of cobalt alkyne complexes -...Fluorination as tool to improve bioanalytical sensitivity and COX-2-selective antitumor activity of cobalt alkyne complexes -...
The cobalt alkyne complex [(prop-2-ynyl)-2-acetoxybenzoate]dicobalthexacarbonyl (Co-ASS) is an auspicious lead, which exhibits ... Fluorination as tool to improve bioanalytical sensitivity and COX-2-selective antitumor activity of cobalt alkyne complexes† ... The cobalt alkyne complex [(prop-2-ynyl)-2-acetoxybenzoate]dicobalthexacarbonyl (Co-ASS) is an auspicious lead, which exhibits ... Fluorination as tool to improve bioanalytical sensitivity and COX-2-selective antitumor activity of cobalt alkyne complexes D. ...
https://pubs.rsc.org/en/content/articlelanding/2019/dt/c9dt03330k/unauth
What are the physical properties of Alkynes?
Lower alkynes upto four carbon atoms are gases, those containing five to thirteen carbon atoms are liquids while higher alkynes ... Alkynes have physical properties similar to alkanes and alkenes. ... 3. Alkynes are sparingly soluble in polar solvents such as ... Lower alkynes upto four carbon atoms are gases, those containing five to thirteen carbon atoms are liquids while higher alkynes ... 1. Alkynes have physical properties similar to alkanes and alkenes. ...
https://www.preservearticles.com/physics/physical-properties-of-alkynes/770
Palladium nanoparticle catalysts in ionic liquids: synthesis, characterisation and selective partial hydrogenation of alkynes...Palladium nanoparticle catalysts in ionic liquids: synthesis, characterisation and selective partial hydrogenation of alkynes...
Palladium nanoparticle catalysts in ionic liquids: synthesis, characterisation and selective partial hydrogenation of alkynes ... Palladium nanoparticle catalysts in ionic liquids: synthesis, characterisation and selective partial hydrogenation of alkynes ...
https://kups.ub.uni-koeln.de/7018/
Reactions of the mixed-metal alkyne-bridged complexes [(η<sup>5</sup>-C<sub>5</sub>H<sub>5</sub>)(OC)<sub>2</sub>M{μ-C <sub>2<...
Reactions of the mixed-metal alkyne-bridged complexes [(η5-C5H5)(OC)2M{μ-C 2(CO2Me)2}Co(CO)3] (M=Mo or W) with Ph2PCCtBu1. In: ... Reactions of the mixed-metal alkyne-bridged complexes [(η5-C5H5)(OC)2M{μ-C 2(CO2Me)2}Co(CO)3] (M=Mo or W) with Ph2PCCtBu1. / ... Reactions of the mixed-metal alkyne-bridged complexes [(η5-C5H5)(OC)2M{μ-C 2(CO2Me)2}Co(CO)3] (M=Mo or W) with Ph2PCCtBu1. ... Reactions of the mixed-metal alkyne-bridged complexes [(η5-C5H5)(OC)2M{μ-C 2(CO2Me)2}Co(CO)3] (M=Mo or W) with Ph2PCCtBu1. ...
https://researchportal.bath.ac.uk/en/publications/reactions-of-the-mixed-metal-alkyne-bridged-complexes-%CE%B7sup5sup-cs
The synthesis of heteroaromatic prostacyclin analogues via keto alkyne cyclisationThe synthesis of heteroaromatic prostacyclin analogues via keto alkyne cyclisation
... Stuart Cook, Douglas Henderson, Kevan A. ... The synthesis of heteroaromatic prostacyclin analogues via keto alkyne cyclisation. , Journal of the Chemical Society Perkin ...
https://www.growkudos.com/publications/10.1039%25252Fp19870001825/reader
4-Arm PEG-Alkyne/NHS - Creative PEGWorks4-Arm PEG-Alkyne/NHS - Creative PEGWorks
Bifunctional 4-Arm PEG-Alkyne/NHS reagents have two functional groups Alkyne and NHS ester at specific ratios of 1:3, 2:2, 3:1 ... Bifunctional 4-Arm PEG-Alkyne/NHS reagents have two functional groups Alkyne and NHS ester at specific ratios of 1:3, 2:2, 3:1 ... The alkyne and NHS ester functionality are quantitated using spectroscopic techniques and colorimetric assays. The NHS ester is ...
https://creativepegworks.com/group/4-arm-peg-alkyne-nhs
One-Pot Synthesis of CF<sub>3</sub>-Substituted Pyrazolines/Pyrazoles from Electron-Deficient Alkenes/Alkynes and CF<sub>3</sub...One-Pot Synthesis of CF<sub>3</sub>-Substituted Pyrazolines/Pyrazoles from Electron-Deficient Alkenes/Alkynes and CF<sub>3</sub...
One-Pot Synthesis of CF3-Substituted Pyrazolines/Pyrazoles from Electron-Deficient Alkenes/Alkynes and CF3CHN2 Generated in ... One-Pot Synthesis of CF3-Substituted Pyrazolines/Pyrazoles from Electron-Deficient Alkenes/Alkynes and CF3CHN2 Generated in ... The [3+2] cycloaddition of CF3CHN2, generated in situ, with electron-deficient alkenes/alkynes affords CF3-substituted ...
https://enamine.net/publications/463-one-pot-synthesis-of-cf3-substituted-pyrazolines-pyrazoles-from-electron-deficient-alkenes-alkynes-and-cf3chn2-generated-in-situ-optimized-synthesis-of-tris-trifluoromethyl-pyrazole
Alkyne-PEG9-N3 | Biopharma PEG
Applicated in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound. ...
https://www.biochempeg.com/product/Alkyne-PEG9-N3.html
Alkynes - Reagents for Click-Conjugation - PEGylation - DRUG DELIVERY - ProductsAlkynes - Reagents for Click-Conjugation - PEGylation - DRUG DELIVERY - Products
Thank you very much for your interest in our products. All prices listed on our website are ex-works, Germany, and may attract customs duties when imported.. You may/will be contacted by the shipping company for additional documentation that may be required by the US Customs for clearance.. We offer you the convenience of buying though a local partner, Peptide Solutions LLC who can import the shipment as well as prepay the customs duties and brokerage on your behalf and provide the convenience of a domestic sale.. Continue to Iris Biotech GmbHSend request to US distributor ...
https://www.iris-biotech.de/en/products/drug-delivery/pegylation/reagents-for-click-conjugation/alkynes.html
Copper-catalyzed fluoroalkylation of alkynes, and alkynyl & vinyCopper-catalyzed fluoroalkylation of alkynes, and alkynyl & viny
Copper-catalyzed fluoroalkylation of alkynes and alkynyl carboxylic acids has been achieved with high functional-group ... Copper-catalyzed fluoroalkylation of alkynes, and alkynyl & vinyl carboxylic acids with fluoroalkyl halides. Jing-Jing Ma, Wen- ... Copper-catalyzed fluoroalkylation of alkynes and alkynyl carboxylic acids has been achieved with high functional-group ...
https://www.researcher-app.com/paper/1650
How will you distinguish between alkanes, alkenes and alkynes?How will you distinguish between alkanes, alkenes and alkynes?
our alkenes alkynes are those which have at least one double bond at least one double bond have like it was a single point ... carbon atoms c2h -2 that is c2h means the general Formula for alkynes and it is also a type of unsaturated hydrocarbon hydro ... hydrocarbon and saturated a dose of the double bond and triple let us discuss alkine sunao water alkenes alkynes are those ... hi everyone lets take a questionnaire the question is how will you distinguish between alkanes alkenes and alkynes have to ...
https://www.doubtnut.com/question-answer-chemistry/how-will-you-distinguish-between-alkanes-alkenes-and-alkynes-643554553
Internal Plasticization of Poly(Vinyl Chloride) using Thermal Azide-Alkyne Huisgen Cycloaddition and Copper-Mediated Atom...Internal Plasticization of Poly(Vinyl Chloride) using Thermal Azide-Alkyne Huisgen Cycloaddition and Copper-Mediated Atom...
Whereas the azide-alkyne approach may be suffered from the potential danger in handling azides on large scale, the ATRP graft ... In the first strategy, thermal azide-alkyne Huisgen cycloaddition was utilized to attach electron-poor acetylenediamides using ... Internal Plasticization of Poly(Vinyl Chloride) using Thermal Azide-Alkyne Huisgen Cycloaddition and Copper-Mediated Atom ...
https://escholarship.org/uc/item/0331s6cr
Utilizing Copper(I) Catalyzed Azide-Alkyne Huisgen 1,3-Dipolar Cycload by Parul Rungta"Utilizing Copper(I) Catalyzed Azide-Alkyne Huisgen 1,3-Dipolar Cycload" by Parul Rungta
Rungta, Parul, "Utilizing Copper(I) Catalyzed Azide-Alkyne Huisgen 1,3-Dipolar Cycloaddition for the Surface Modification of ... Utilizing Copper(I) Catalyzed Azide-Alkyne Huisgen 1,3-Dipolar Cycloaddition for the Surface Modification of Colloidal ... catalyzed azide-alkyne cycloaddition. (CuAAC) (i.e., "click" transformation) to produce fluoroprobes with a large Stokes shift ...
https://tigerprints.clemson.edu/all_dissertations/660/
Pin-point chemical modification of RNA with diverse molecules through the functionality transfer reaction and the copper...
... modification of RNA with diverse molecules through the functionality transfer reaction and the copper-catalyzed azide-alkyne ... modification of RNA with diverse molecules through the functionality transfer reaction and the copper-catalyzed azide-alkyne ... modification of RNA with diverse molecules through the functionality transfer reaction and the copper-catalyzed azide-alkyne ... modification of RNA with diverse molecules through the functionality transfer reaction and the copper-catalyzed azide-alkyne ...
https://kyushu-u.pure.elsevier.com/en/publications/pin-point-chemical-modification-of-rna-with-diverse-molecules-thr
Modular Medical Imaging Agents Based on Azide-Alkyne Huisgen Cycloadditions: Synthesis and Pre-Clinical Evaluation of(18)F...Modular Medical Imaging Agents Based on Azide-Alkyne Huisgen Cycloadditions: Synthesis and Pre-Clinical Evaluation of(18)F...
Modular Medical Imaging Agents Based on Azide-Alkyne Huisgen Cycloadditions: Synthesis and Pre-Clinical Evaluation of(18)F- ... Corrigendum: Modular Medical Imaging Agents Based on Azide-Alkyne Huisgen Cycloadditions: Synthesis and Pre-Clinical Evaluation ...
https://research.rug.nl/nl/publications/modular-medical-imaging-agents-based-on-azide-alkyne-huisgen-cycl/publications/?type=%2Fdk%2Fatira%2Fpure%2Fresearchoutput%2Fresearchoutputtypes%2Fcontributiontojournal%2Ferratum
Ruthenium-catalyzed aerobic oxidative cyclization of aromatic and heteroaromatic nitriles with alkynes: A new route to...Ruthenium-catalyzed aerobic oxidative cyclization of aromatic and heteroaromatic nitriles with alkynes: A new route to...
title = "Ruthenium-catalyzed aerobic oxidative cyclization of aromatic and heteroaromatic nitriles with alkynes: A new route to ... Ruthenium-catalyzed aerobic oxidative cyclization of aromatic and heteroaromatic nitriles with alkynes: A new route to ... Ruthenium-catalyzed aerobic oxidative cyclization of aromatic and heteroaromatic nitriles with alkynes : A new route to ... Ruthenium-catalyzed aerobic oxidative cyclization of aromatic and heteroaromatic nitriles with alkynes : A new route to ...
https://cris.bgu.ac.il/en/publications/ruthenium-catalyzed-aerobic-oxidative-cyclization-of-aromatic-and
3 Alkenes & Alkynes - Organic Chemistry3 Alkenes & Alkynes - Organic Chemistry
Markovnikovs Rule and Addn of ...
http://organic.chemcrazy.com/3-alkenes-alkynes
Browsing 2018 by Subject "alkynes"
... and coordination reactions show that alkynes (RCCR) attain 1,2‐dicarbene nature during CCR angle ... ...
http://ir.niist.res.in:8080/xmlui/handle/123456789/2964/browse?type=subject&value=alkynes
Halogenation of Alkynes - Master Organic ChemistryHalogenation of Alkynes - Master Organic Chemistry
Halogenation of Alkynes. Description: Treatment of alkynes with one equivalent of a halogen (Cl2, Br2, I2) results in an ...
https://www.masterorganicchemistry.com/reaction-guide/halogenation-of-alkynes/
Online Alkynes and Alcohols Chemistry Assignment HelpOnline Alkynes and Alcohols Chemistry Assignment Help
Homework Assignment Help is most useful online help portal for the students that providing all Online Alkynes and Alcohols ... Online Alkynes and Alcohols Chemistry Assignment Help. Alkynes include the class of organic compounds when at least one or more ... Uses of Alkyne. *Acetylene is used in the form of oxy-acetylene flame in welding and cutting tools . ... Methods of Preparation of Alkynes. Industrial method : It is prepared by the hydrolysis of calcium carbide ...
https://www.homeworkassignmenthelp.com/alkynes-and-alcohols-online.aspx
Alkenes and Alkynes - Chemistry Video | Clutch PrepAlkenes and Alkynes - Chemistry Video | Clutch Prep
Video explaining Alkenes and Alkynes for Chemistry. This is one of many videos provided by Clutch Prep to prepare you to ... Under a Hydrohalogenation reaction an alkene or alkyne reacts with HCl or HBr to add a hydrogen and halogen to the pi bond. ... Under Hydrogenation an alkene or alkyne reacts with hydrogen gas (H2) over a metal catalyst in order to remove pi bonds. ... Here were going to say that alkenes and alkynes undergo addition reactions, so were adding to them, in which elements add ...
https://www.clutchprep.com/chemistry/alkenes-and-alkynes/6845/learn/3995
Cy3-Alkyne - DC BiosciencesCy3-Alkyne - DC Biosciences
The orange-fluorescent Cy®3 Alkyne can be reacted with azides via a copper-catalysed click reaction (CuAAC). Cy®3 is a water- ... This sulfonated dye is also known as sulfo-Cyanine3 Alkyne. Cy® Dye is a trademark of GE Healthcare. ... The orange-fluorescent Cy®3 Alkyne can be reacted with azides via a copper-catalysed click reaction (CuAAC). Cy®3 is a water- ... This sulfonated dye is also known as sulfo-Cyanine3 Alkyne. Cy® Dye is a trademark of GE Healthcare. ...
https://dcbiosci.com/product/cy3-alkyne/
Cy3 Alkyne | ABP Biosciences Cy3 Alkyne | ABP Biosciences
The click reaction involves a copper-catalyzed triazole formation from an azide and an alkyne. The azide and alkyne moieties ... The Cy3 alkyne is reactive with azide via a copper-catalyzed click reaction that allows the subsequent visualization by ...
https://www.abpbio.com/product/cy3-alkyne/
Alkenes and alkynesAzide-alkyne cycloadditionCycloadditionAcetyleneAlkene and alkyneSynthesisAliphaticAlkanesReagentsTerminalAzides viaCarboxylic acidsReactionOrange-fluorescentHeteroaromaticCuAACNucleophilicCobaltSolubleOrganic compoundsChemistryFluorescentQuantitativeBondsFunctionalityClickHigherGeneralLower
Alkenes and alkynes6
  • How will you distinguish between alkanes, alkenes and alkynes? (doubtnut.com)
  • The presence of pi bonds in both alkenes and alkynes allows them to undergo Addition Reactions . (clutchprep.com)
  • Here we're going to say that alkenes and alkynes undergo addition reactions, so we're adding to them, in which elements add across their pi bonds to create new sigma bonds. (clutchprep.com)
  • Alkenes and alkynes can be transformed into almost any other functional group you can name! (leslutinsduphoenix.com)
  • We will review their nomenclature, and also learn about the vast possibility of reactions using alkenes and alkynes as starting materials. (leslutinsduphoenix.com)
  • You can treat alkenes and alkynes as functional groups. (rsc.org)
Azide-alkyne cycloaddition1
  • This work represents our initial effort in identifying azide/alkyne pairs for optimal reactivity in copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions. (mdpi.com)
Cycloaddition3
  • The [3+2] cycloaddition of CF 3 CHN 2 , generated in situ, with electron-deficient alkenes/alkynes affords CF 3 -substituted pyrazolines/pyrazoles in quantitative yields. (enamine.net)
  • In the first strategy, thermal azide-alkyne Huisgen cycloaddition was utilized to attach electron-poor acetylenediamides using a branched glutamic acid linker to azidized PVC, incorporating four plasticizing moieties per attachment point. (escholarship.org)
  • A versatile route for the synthesis of highly functionalized, polyanionic macromolecules based on dendritic polyglycerol was applied by means of the Huisgen-Sharpless-Meldal 1,3-dipolar cycloaddition ("click-reaction") of polyglycerolazide precursors and alkyne-functionalized anions such as sulfonates, carboxylates, phosphonates, and bisphosphonates. (fu-berlin.de)
Acetylene2
  • As an alkyne , acetylene is bonded together in a triple bond. (hindlish.com)
  • Under ambient conditions, [email protected] showed remarkable adsorption of alkynes and efficient separations of acetylene/ethylene, propyne/propylene, and butyne/1,3-butadiene mixtures, with unprecedented dynamic separation selectivities of 100, 92, and 83, respectively. (nankai.edu.cn)
Alkene and alkyne1
  • Based on reductive ozonolysis reaction, how do you distinguish between an alkene and alkyne? (doubtnut.com)
Synthesis1
  • Reduction of alkynes is a useful method for the stereoselective synthesis of disubstituted alkenes. (leslutinsduphoenix.com)
Aliphatic1
  • The homodimerisation of terminal alkynes is found to proceed with high gem selectivity when employing aliphatic alkynes, whereas the reaction resulted in high Z-selectivity with aromatic alkynes, showing that the selectivity is dependent on the nature of the alkyne used. (hacettepe.edu.tr)
Alkanes1
Reagents1
  • Bifunctional 4-Arm PEG-Alkyne/NHS reagents have two functional groups Alkyne and NHS ester at specific ratios of 1:3, 2:2, 3:1. (creativepegworks.com)
Terminal9
  • Glaser‐like coupling of terminal alkynes by thermal activation is extensively used in on‐surface chemistry. (usc.es)
  • We used voltage pulses from the tip to trigger a Glaser‐like coupling between terminal alkyne carbons within a custom‐synthesized precursor molecule adsorbed on bilayer NaCl on Cu(111). (usc.es)
  • How will you distinguish between terminal alkyne and nonteminal alkyne. (doubtnut.com)
  • The carbanions generated by deprotonation of terminal alkynes are called acetylides. (hindlish.com)
  • Vinyl silyl can be made from terminal alkyne or other methods. (hindlish.com)
  • Because trialkylsilyl groups are very commonly used to protect the terminal C-H of an alkyne, pro- tiodesilylation back to the parent alkyne is an important transformation. (gelest.com)
  • The same ruthenium complex was also shown to catalyse carboxylic acid (acetic acid, trichloroacetic acid, trans-2-octenoic acid, 4-cyclooctenoic acid) addition to terminal alkynes. (hacettepe.edu.tr)
  • The reactions of enoic acids, showed a high selectivity towards carboxylic acid addition to the triple bond of terminal alkynes, rather than triple bond addition to the double bond of the enoic acids. (hacettepe.edu.tr)
  • To evaluate the results obtained from the carboxylic acid addition reaction of terminal alkynes, the homodimerisation of terminal alkynes (phenylacetylene, 1-octyne, 1-heptyne) was also studied. (hacettepe.edu.tr)
Azides via2
  • The orange-fluorescent Cy®3 Alkyne can be reacted with azides via a copper-catalysed click reaction (CuAAC). (dcbiosci.com)
  • AZDye™ 546 Alkyne reacts with azides via a copper-catalyzed click reaction (CuAAC) to form a stable triazole linker. (clickchemistrytools.com)
Carboxylic acids2
  • PPh 3 AuCl/AgPF 6 -catalyzed hydroacyloxylation of alkynes with carboxylic acids affords the Markonikov addition products, whereas PPh 3 AuCl/AgOTf catalyst gives the more stable isomerized products via the Markonikov products. (organic-chemistry.org)
  • Copper-catalyzed fluoroalkylation of alkynes and alkynyl carboxylic acids has been achieved with high functional-group tolerance and excellent regio- and stereoselectivities. (researcher-app.com)
Reaction6
  • The click reaction involves a copper-catalyzed triazole formation from an azide and an alkyne. (abpbio.com)
  • The Cy3 alkyne is reactive with azide via a copper-catalyzed click reaction that allows the subsequent visualization by fluorescence spectroscopy. (abpbio.com)
  • We report on a novel reaction protocol for the coupling of arenes with alkynes (the Fujiwara reaction), yielding products of formal trans-hydroarylation of the triple bond. (unipd.it)
  • We discuss the applicability of this reaction protocol, which appears at present quite general with respect to the alkyne, albeit limited to electron-rich arenes. (unipd.it)
  • We report here on a chromium-catalyzed addition reaction of an arylmagnesium bromide to an unactivated internal alkyne to afford an ortho-alkenylarylmagnesium bromide. (elsevier.com)
  • This reaction likely proceeds via the insertion of an alkyne into an arylchromium species, alkenyl-to-aryl 1,4-chromium migration, and transmetalation between the resulting arylchromium species and the starting aryl Grignard reagent. (elsevier.com)
Orange-fluorescent1
  • AZDye™ 546 Alkyne is a bright, orange-fluorescent alkyne-activated probe routinely used for imaging of low abundance azide-containing biomolecules. (clickchemistrytools.com)
Heteroaromatic1
  • Reddy, MC, Manikandan, R & Jeganmohan, M 2013, ' Ruthenium-catalyzed aerobic oxidative cyclization of aromatic and heteroaromatic nitriles with alkynes: A new route to isoquinolones ', Chemical Communications , vol. 49, no. 54, pp. 6060-6062. (bgu.ac.il)
CuAAC1
  • In the current work, two types of alkynes are shown to undergo rapid CuAAC reactions under both copper(II)- (via an induction period) and copper(I)-catalyzed conditions. (mdpi.com)
Nucleophilic1
  • Angles for nucleophilic attack on alkynes were reviewed and redefined recently. (hindlish.com)
Cobalt1
  • The cobalt alkyne complex [(prop-2-ynyl)-2-acetoxybenzoate]dicobalthexacarbonyl (Co-ASS) is an auspicious lead, which exhibits its anticancer activity mainly by inhibition of both cyclooxygenases (COX-1 and COX-2). (rsc.org)
Soluble1
  • 3. Alkynes are sparingly soluble in polar solvents such as water but are readily soluble in organic solvents such as benzene, ether, acetone, etc. (preservearticles.com)
Organic compounds1
  • Alkynes include the class of organic compounds when at least one or more carbon-carbon triple bond is present. (homeworkassignmenthelp.com)
Chemistry1
  • Tobisu, M , Nakai, H & Chatani, N 2009, ' Platinum and ruthenium chloride-catalyzed cycloisomerization of 1-alkyl-2-ethynylbenzenes: Interception of π-activated alkynes with a benzylic C-H bond ', Journal of Organic Chemistry , vol. 74, no. 15, pp. 5471-5475. (elsevier.com)
Fluorescent1
  • Tide Fluor™ 3 alkyne [TF3 alkyne] is a strong fluorescent dye used for labeling peptides and nucleotides. (scbt.com)
Quantitative1
  • N-myristoylated proteins from VACV and the host were metabolically labelled with myristic acid alkyne during infection using quantitative chemical proteomics. (cdc.gov)
Bonds1
  • The first type of the alkynes bears relatively acidic ethynyl C-H bonds, while the second type contains an N -(triazolylmethyl)propargylic moiety that produces a self-accelerating effect. (mdpi.com)
Functionality1
  • The alkyne and NHS ester functionality are quantitated using spectroscopic techniques and colorimetric assays. (creativepegworks.com)
Click1
  • 2016) Biocompatible Azide-Alkyne "Click" Reactions for Surface Decoration of Glyco-Engineered Cells. (jenabioscience.com)
Higher1
  • Lower alkynes upto four carbon atoms are gases, those containing five to thirteen carbon atoms are liquids while higher alkynes are solids. (preservearticles.com)
General1
  • Hidrocarburos con al menos un triple enlace en la porción lineal, con fórmula general Cn-H2n-2. (bvsalud.org)
Lower1
  • The efficient removal of alkyne impurities for the production of polymer-grade lower olefins remains an important and challenging goal for many industries. (nankai.edu.cn)
Thomas POISSON | Institut national des sciences appliquées de Rouen
Thomas POISSON | Institut national des sciences appliquées de Rouen (insa-rouen.fr)
Gold(I)-Catalyzed Addition of Carboxylic Acids to Alkynes
Gold(I)-Catalyzed Addition of Carboxylic Acids to Alkynes (organic-chemistry.org)
Characterization Of Benzoporphyrin Derivative, A New Photosensitizer | Semantic Scholar
Characterization Of Benzoporphyrin Derivative, A New Photosensitizer | Semantic Scholar (semanticscholar.org)
Micrometre-long covalent organic fibres by photoinitiated chain-growth radical polymerization on an alkali-halide surface |...
Micrometre-long covalent organic fibres by photoinitiated chain-growth radical polymerization on an alkali-halide surface |... (nature.com)
Permalien vers Palladium-Catalyzed Regio- and Stereoselective Carbothiolation of Terminal Alkynes with Azolyl Sulfides
Permalien vers Palladium-Catalyzed Regio- and Stereoselective Carbothiolation of Terminal Alkynes with Azolyl Sulfides (research.pasteur.fr)
Synthese von fusionierten Naphthobenzofuranen - Thieme Chemistry - Georg Thieme Verlag KG
Synthese von fusionierten Naphthobenzofuranen - Thieme Chemistry - Georg Thieme Verlag KG (thieme.de)
General, Organic, and Biological Chemistry: Pearson New Internati
General, Organic, and Biological Chemistry: Pearson New Internati (pearson.fr)
Vauthey Research Group - Group Members
Vauthey Research Group - Group Members (unige.ch)
Etude de la réactivité (régiosélectivité et/ou stéréosélectivité) d'un acide dithiophosphorique sur des alcynes soufrés -...
Etude de la réactivité (régiosélectivité et/ou stéréosélectivité) d'un acide dithiophosphorique sur des alcynes soufrés -... (hal.univ-lorraine.fr)
Stereodivergent total synthesis of rocaglaol initiated by synergistic dual-metal-catalyzed asymmetric allylation of benzofuran...
Stereodivergent total synthesis of rocaglaol initiated by synergistic dual-metal-catalyzed asymmetric allylation of benzofuran... (cell.com)
Hydrogenation (video) | Alkene reactions | Khan Academy
Hydrogenation (video) | Alkene reactions | Khan Academy (khanacademy.org)
Publications - Concordia University
Publications - Concordia University (concordia.ca)
Atom-Economical Chemoselective Synthesis of 1,4-Diynes and Polysubstituted Furans/Pyrroles from Propargyl Alcohols and Terminal...
Atom-Economical Chemoselective Synthesis of 1,4-Diynes and Polysubstituted Furans/Pyrroles from Propargyl Alcohols and Terminal... (organic-chemistry.org)
Organic Chemistry Online Course] | Educator.com
Organic Chemistry Online Course] | Educator.com (educator.com)
Find Research outputs - Universidade NOVA de Lisboa
Find Research outputs - Universidade NOVA de Lisboa (novaresearch.unl.pt)
Ethane, with the molecular formula C2H6, has(a) 6 covalent bonds
Ethane, with the molecular formula C2H6, has(a) 6 covalent bonds (tutorialspoint.com)
Heat Transfer (Easy) - Engineering Entrance
Heat Transfer (Easy) - Engineering Entrance (tcyonline.com)
Density alkane alkene cycloalkane cycloalkene benzene alkylbenzene methylalkane carbon number methylalkene alcohol carboxylic...
Density alkane alkene cycloalkane cycloalkene benzene alkylbenzene methylalkane carbon number methylalkene alcohol carboxylic... (engineeringtoolbox.com)
IISER's tryst with click chemistry - The Hindu BusinessLine
IISER's tryst with click chemistry - The Hindu BusinessLine (thehindubusinessline.com)
Chemicals Catalog, China Chemicals Products Directory - Hisupplier.com
Chemicals Catalog, China Chemicals Products Directory - Hisupplier.com (hisupplier.com)
Transition-Metal-Free Cleavage of C-C Triple Bonds in Aromatic Alkynes with S8 and Amides Leading to Aryl Thioamides
Transition-Metal-Free Cleavage of C-C Triple Bonds in Aromatic Alkynes with S8 and Amides Leading to Aryl Thioamides (organic-chemistry.org)
Visible-Light-Driven Alkyne Hydro-/Carbocarboxylation Using CO2 via Iridium/Cobalt Dual Catalysis for Divergent Heterocycle...
Visible-Light-Driven Alkyne Hydro-/Carbocarboxylation Using CO2 via Iridium/Cobalt Dual Catalysis for Divergent Heterocycle... (organic-chemistry.org)
Publikationen | Max-Planck-Institut für Polymerforschung
Publikationen | Max-Planck-Institut für Polymerforschung (mpip-mainz.mpg.de)
Frontiers | Flash functional group-tolerant biaryl-synthesis based on integration of lithiation, zincation and negishi coupling...
Frontiers | Flash functional group-tolerant biaryl-synthesis based on integration of lithiation, zincation and negishi coupling... (frontiersin.org)
Find Research outputs - Heriot-Watt Research Portal
Find Research outputs - Heriot-Watt Research Portal (researchportal.hw.ac.uk)
Liposomes derivatized with multimeric copies of KCCYSL peptide as targ | IJN
Liposomes derivatized with multimeric copies of KCCYSL peptide as targ | IJN (dovepress.com)
YU-HUI HOU
YU-HUI HOU (ias.ac.in)
Label as you fold: methyltransferase-assisted functionalization of DNA nanostructures - Nanoscale (RSC Publishing) DOI:10...
Label as you fold: methyltransferase-assisted functionalization of DNA nanostructures - Nanoscale (RSC Publishing) DOI:10... (pubs.rsc.org)
Hydroamination of Alkenes and Alkynes with Group 2 Centred Catalysts - Research output - the University of Bath's research...
Hydroamination of Alkenes and Alkynes with Group 2 Centred Catalysts - Research output - the University of Bath's research... (researchportal.bath.ac.uk)
Vinyl iodide synthesis by iodination or substitution
Vinyl iodide synthesis by iodination or substitution (organic-chemistry.org)
Organic Functional Group Transformation
Organic Functional Group Transformation (organic-chemistry.org)