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AlkynesCyclizationRhodiumClick ChemistryAlkenesStereoisomerismMolecular StructureCatalysisPropanolsAzidesPalladiumCycloparaffinsAlkadienesRutheniumCycloaddition ReactionAminationIminesTrimeprazineVinyl CompoundsOrganometallic CompoundsSilanesOrganogold CompoundsOrganosilicon CompoundsHempaIsocyanatesDiynesCombinatorial Chemistry TechniquesKetonesHeterocyclic CompoundsCopperEncyclopedias as TopicChemistry, OrganicAcetyleneTerminology as TopicHistory, 19th CenturyHistory, 20th CenturyCarbon MonoxideHydrocarbonsSulfonium CompoundsNitrogen CompoundsAcids, HeterocyclicTextbooks as TopicAlkanesPolycyclic Hydrocarbons, AromaticSodium HydroxideTransition TemperatureAmmoniaMethylene BlueSodiumElectronsCommercePurchasing, HospitalLeasing, Property
Alkynes
Hydrocarbons with at least one triple bond in the linear portion, of the general formula Cn-H2n-2.
Cyclization
Changing an open-chain hydrocarbon to a closed ring. (McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
Rhodium
Rhodium. A hard and rare metal of the platinum group, atomic number 45, atomic weight 102.905, symbol Rh. (Dorland, 28th ed)
Click Chemistry
Organic chemistry methodology that mimics the modular nature of various biosynthetic processes. It uses highly reliable and selective reactions designed to "click" i.e., rapidly join small modular units together in high yield, without offensive byproducts. In combination with COMBINATORIAL CHEMISTRY TECHNIQUES, it is used for the synthesis of new compounds and combinatorial libraries.
Alkenes
Unsaturated hydrocarbons of the type Cn-H2n, indicated by the suffix -ene. (Grant & Hackh's Chemical Dictionary, 5th ed, p408)
Stereoisomerism
The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
Molecular Structure
The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.
Catalysis
The facilitation of a chemical reaction by material (catalyst) that is not consumed by the reaction.
Propanols
Isomeric forms and derivatives of PROPANOL (C3H7OH).
Azides
Organic or inorganic compounds that contain the -N3 group.
Palladium
A chemical element having an atomic weight of 106.4, atomic number of 46, and the symbol Pd. It is a white, ductile metal resembling platinum, and following it in abundance and importance of applications. It is used in dentistry in the form of gold, silver, and copper alloys.
Cycloparaffins
Alicyclic hydrocarbons in which three or more of the carbon atoms in each molecule are united in a ring structure and each of the ring carbon atoms is joined to two hydrogen atoms or alkyl groups. The simplest members are cyclopropane (C3H6), cyclobutane (C4H8), cyclohexane (C6H12), and derivatives of these such as methylcyclohexane (C6H11CH3). (From Sax, et al., Hawley's Condensed Chemical Dictionary, 11th ed)
Alkadienes
Acyclic branched or unbranched hydrocarbons having two carbon-carbon double bonds.
Ruthenium
A hard, brittle, grayish-white rare earth metal with an atomic symbol Ru, atomic number 44, and atomic weight 101.07. It is used as a catalyst and hardener for PLATINUM and PALLADIUM.
Cycloaddition Reaction
Synthetic organic reactions that use reactions between unsaturated molecules to form cyclical products.
Amination
The creation of an amine. It can be produced by the addition of an amino group to an organic compound or reduction of a nitro group.
Imines
Trimeprazine
A phenothiazine derivative that is used as an antipruritic.
Vinyl Compounds
Organometallic Compounds
A class of compounds of the type R-M, where a C atom is joined directly to any other element except H, C, N, O, F, Cl, Br, I, or At. (Grant & Hackh's Chemical Dictionary, 5th ed)
Silanes
Compounds similar to hydrocarbons in which a tetravalent silicon atom replaces the carbon atom. They are very reactive, ignite in air, and form useful derivatives.
Organogold Compounds
Organic compounds that contain GOLD as an integral part of the molecule. Some are used as ANTIRHEUMATIC AGENTS. The term chrysotherapy derives from an ancient Greek term for gold.
Organosilicon Compounds
Organic compounds that contain silicon as an integral part of the molecule.
Hempa
A chemosterilant agent that is anticipated to be a carcinogen.
Isocyanates
Organic compounds that contain the -NCO radical.
Diynes
Compounds with two triple bonds. Some of them are CYTOTOXINS.
Combinatorial Chemistry Techniques
A technology, in which sets of reactions for solution or solid-phase synthesis, is used to create molecular libraries for analysis of compounds on a large scale.
Ketones
Heterocyclic Compounds
Ring compounds having atoms other than carbon in their nuclei. (Grant & Hackh's Chemical Dictionary, 5th ed)
Copper
A heavy metal trace element with the atomic symbol Cu, atomic number 29, and atomic weight 63.55.
Encyclopedias as Topic
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
Chemistry, Organic
The study of the structure, preparation, properties, and reactions of carbon compounds. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
Acetylene
Terminology as Topic
The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.
History, 19th Century
Time period from 1801 through 1900 of the common era.
History, 20th Century
Time period from 1901 through 2000 of the common era.
Carbon Monoxide
Carbon monoxide (CO). A poisonous colorless, odorless, tasteless gas. It combines with hemoglobin to form carboxyhemoglobin, which has no oxygen carrying capacity. The resultant oxygen deprivation causes headache, dizziness, decreased pulse and respiratory rates, unconsciousness, and death. (From Merck Index, 11th ed)
Hydrocarbons
Sulfonium Compounds
Sulfur compounds in which the sulfur atom is attached to three organic radicals and an electronegative element or radical.
Nitrogen Compounds
Inorganic compounds that contain nitrogen as an integral part of the molecule.
Acids, Heterocyclic
A class of acids containing a ring structure in which at least one atom other than CARBON is incorporated.
Textbooks as Topic
Books used in the study of a subject that contain a systematic presentation of the principles and vocabulary of a subject.
Alkanes
The generic name for the group of aliphatic hydrocarbons Cn-H2n+2. They are denoted by the suffix -ane. (Grant & Hackh's Chemical Dictionary, 5th ed)
Polycyclic Hydrocarbons, Aromatic
A major group of unsaturated cyclic hydrocarbons containing two or more rings. The vast number of compounds of this important group, derived chiefly from petroleum and coal tar, are rather highly reactive and chemically versatile. The name is due to the strong and not unpleasant odor characteristic of most substances of this nature. (From Hawley's Condensed Chemical Dictionary, 12th ed, p96)
Sodium Hydroxide
A highly caustic substance that is used to neutralize acids and make sodium salts. (From Merck Index, 11th ed)
Transition Temperature
The temperature at which a substance changes from one state or conformation of matter to another.
Ammonia
A colorless alkaline gas. It is formed in the body during decomposition of organic materials during a large number of metabolically important reactions. Note that the aqueous form of ammonia is referred to as AMMONIUM HYDROXIDE.
Methylene Blue
A compound consisting of dark green crystals or crystalline powder, having a bronze-like luster. Solutions in water or alcohol have a deep blue color. Methylene blue is used as a bacteriologic stain and as an indicator. It inhibits GUANYLATE CYCLASE, and has been used to treat cyanide poisoning and to lower levels of METHEMOGLOBIN.
Sodium
A member of the alkali group of metals. It has the atomic symbol Na, atomic number 11, and atomic weight 23.
Electrons
Stable elementary particles having the smallest known negative charge, present in all elements; also called negatrons. Positively charged electrons are called positrons. The numbers, energies and arrangement of electrons around atomic nuclei determine the chemical identities of elements. Beams of electrons are called CATHODE RAYS.
Commerce
The interchange of goods or commodities, especially on a large scale, between different countries or between populations within the same country. It includes trade (the buying, selling, or exchanging of commodities, whether wholesale or retail) and business (the purchase and sale of goods to make a profit). (From Random House Unabridged Dictionary, 2d ed, p411, p2005 & p283)
Purchasing, Hospital
Hospital department responsible for the purchasing of supplies and equipment.
Leasing, Property
Contractual arrangement between the lessor (owner) and the lessee in which the use of equipment or facilities is granted to the lessee for a period of time and at a specified rate.

Smoothing of the thermal stability of DNA duplexes by using modified nucleosides and chaotropic agents. (1/688)

The effect of alkyltrimethylammonium ions on the thermostability of natural and modified DNA duplexes has been investigated. We have shown that the use of tetramethylammonium ions TMA+along with the chemical modification of duplexes allow the fine adjustment of T m and the possibility of obtaining several duplex systems with varied isostabilizedtemperatures, some of which show greater stability than those of natural DNA. This approach could be very useful for DNA sequencing by hybridization.  (+info)

Inhibition of glutathione synthesis with propargylglycine enhances N-acetylmethionine protection and methylation in bromobenzene-treated Syrian hamsters. (2/688)

The finding that liver necrosis caused by the environmental glutathione (GSH)-depleting chemical, bromobenzene (BB) is associated with marked impairment in O- and S-methylation of BB metabolites in Syrian hamsters raises questions concerning the role of methyl deficiency in BB toxicity. N-Acetylmethionine (NAM) has proven to be an effective antidote against BB toxicity when given after liver GSH has been depleted extensively. The mechanism of protection by NAM may occur via a replacement of methyl donor and/or via an increase of GSH synthesis. If replacement of the methyl donor is an important process, then blocking the resynthesis of GSH in the methyl-repleted hamsters should not decrease NAM protection. This hypothesis was examined in this study. Propargylglycine (PPG), an irreversible inhibitor of cystathionase, was used to inhibit the utilization of NAM for GSH resynthesis. Two groups of hamsters were pretreated with an intraperitoneal (ip) dose of PPG (30 mg/kg) or saline 24 h before BB administration (800 mg/kg, ip). At 5 h after BB treatment, an ip dose of NAM (1200 mg/kg) was given. Light microscopic examinations of liver sections obtained 24 h after BB treatment indicated that NAM provided better protection (P < 0.05) in the PPG + BB + NAM group than in the BB + NAM group. Liver GSH content, however, was lower in the PPG + BB + NAM group than in the BB + NAM group. The Syrian hamster has a limited capability to N-deacetylated NAM. The substitution of NAM with methionine (Met; 450 mg/kg) resulted in a higher level of GSH in the BB + Met group than in the BB + NAM group (P < 0.05). The enhanced protection by PPG in the PPG + BB + NAM group was accompanied by higher (P < 0.05) urinary excretions of specificO- and S-methylated bromothiocatechols than in the BB + NAM group. The results suggest that NAM protection occurs primarily via a replacement of the methyl donor and that methyl deficiency occurring in response to GSH repletion plays a potential role in BB toxicity.  (+info)

Inhibition of gene expression by anti-sense C-5 propyne oligonucleotides detected by a reporter enzyme. (3/688)

Using a reporter plasmid containing the luciferase gene under the control of the insulin-like growth factor 1 (IGF-1) promoter region [including its 5' untranslated region (UTR)], we demonstrate that a 17-mer oligophosphorothioate containing C-5 propyne pyrimidines is able to inhibit luciferase gene expression in the nanomolar concentration range when the anti-sense oligonucleotide is targeted either to a coding sequence in the luciferase gene or to the 5' UTR of the gene for IGF-1. Inhibition was obtained independently of whether the plasmid and the anti-sense oligonucleotide were co-transfected or transfected separately into hepatocarcinoma cells. However, the efficiency of inhibition by the anti-sense oligonucleotides was 10-fold greater in the first case. The unmodified oligophosphorothioate targeted to the 5' UTR of IGF-1 did not inhibit luciferase gene expression at a 100-fold higher concentration unless its length was increased from 17 to 21 nt, in which case an inhibition of gene expression was obtained and an IC50 of 200 nM was observed.  (+info)

Elevated expression of liver gamma-cystathionase is required for the maintenance of lactation in rats. (4/688)

Liver gamma-cystathionase activity increases in rats during lactation; its inhibition due to propargylglycine is followed by a significant decrease in lactation. This is reversible by N-acetylcysteine administration. To study the role of liver gamma-cystathionase and the intertissue flux of glutathione during lactation, we used lactating and virgin rats fed liquid diets. Virgin rats were divided into two groups as follows: one group was fed daily a diet containing the same amount of protein that was consumed the previous day by lactating rats (high protein diet-fed rats); the other virgin group was fed the normal liquid diet (control). The expression and activity of liver gamma-cystathionase were significantly greater in lactating rats and in high protein diet-fed virgin rats compared with control rats. The total glutathione [reduced glutathione (GSH) + oxidized glutathione (GSSG)] released per gram of liver did not differ in lactating rats or in high protein diet-fed rats, but it was significantly higher in these two groups than in control virgin rats. Liver size and the GSH + GSSG released by total liver were significantly higher in lactating rats than in high protein diet-fed virgin rats, and this difference was similar to the amount of glutathione taken up by the mammary gland (454.2 +/- 36.0 nmol/min). The uptake of total glutathione by the lactating mammary gland was much higher than the uptakes of free L-cysteine and L-cystine, which were negligible. These data suggest that the intertissue flux of glutathione is an important mechanism of L-cysteine delivery to the lactating mammary gland, which lacks gamma-cystathionase activity. This emphasizes the physiologic importance of the increased expression and activity of liver gamma-cystathionase during lactation.  (+info)

Guest exchange in an encapsulation complex: a supramolecular substitution reaction. (5/688)

Encapsulation complexes are reversibly formed assemblies in which small molecule guests are completely surrounded by large molecule hosts. The assemblies are held together by weak intermolecular forces and are dynamic: they form and dissipate on time scales ranging from milliseconds to days-long enough for many interactions, even reactions, to take place within them. Little information is available on the exchange process, how guests get in and out of these complexes. Here we report that these events can be slow enough for conventional kinetic studies, and reactive intermediates can be detected. Guest exchange has much in common with familiar chemical substitution reactions, but differs in some respects: no covalent bonds are made or broken, the substrate is an assembly rather than a single molecule, and at least four molecules are involved in multiple rate-determining steps.  (+info)

Effects of a lipoxygenase inhibitor, panaxynol, on vascular contraction induced by angiotensin II. (6/688)

We investigated whether a lipoxygenase inhibitor, panaxynol, affected the vascular contraction induced by angiotensin (Ang) II and the mean arterial pressure in spontaneously hypertensive rats (SHR). Panaxynol suppressed dose-dependently the contractile responses induced by 30 nM Ang II in isolated intact and endothelial cell-denuded aorta in the hamster. IC50 values in the intact and endothelial cell-denuded aorta were 23 and 20 microM, respectively. In SHR, the mean arterial pressure after injection of 30 and 60 mg/kg panaxynol was reduced, and the maximum hypotensive values were 23 and 48 mmHg, respectively. Thus, lipoxygenase products may affect the renin-angiotensin system.  (+info)

Similarity and dissimilarity in mode and mechanism of action between YT-146, a selective adenosine receptor A2 agonist, and adenosine in isolated canine hearts. (7/688)

To elucidate the differences in mode and mechanism of action between YT-146, a highly selective adenosine A2 receptor agonist, and adenosine, we compared their effects on coronary circulation and myocardium and modifications of these effects by glibenclamide, a blocker of ATP-sensitive potassium (K) channels, in three kinds of isolated, blood-perfused canine heart preparations. YT-146 and adenosine were injected i.a. In all preparations both YT-146 and adenosine increased coronary blood flow and in this respect YT-146 was about 5 times as potent as adenosine. The increase in blood flow caused by adenosine was transient, whereas that produced by YT-146 was biphasic; the transient increase was followed by a sustained one. In isolated, blood-perfused sinoatrial (SA) node preparations, YT-146 failed to affect sinus rate, whereas adenosine reduced sinus rate by about 38% at its maximum effect. In isolated, blood-perfused atrioventricular (AV) node preparations, when injected into the artery supplying the AV node, YT-146 exerted no effect on AV conduction time, whereas adenosine prolonged AV conduction time by about 17% at the maximum effect. In isolated, blood-perfused papillary muscle preparations, the force of contraction was affected by neither YT-146 nor adenosine. In the same preparations the effect of YT-146 in increasing coronary blood flow was antagonized by glibenclamide in such a manner that the maximum increase was suppressed, but that of adenosine was not. Reactive hyperemia induced by ischemia for 30 seconds was not affected by glibenclamide. These results suggest that although both YT-146 and adenosine produce an increase in coronary blood flow via adenosine A2 receptors, the opening of ATP- or glibenclamide-sensitive K channels is involved in the action of the former, but scarcely in the action of the latter. The opening of ATP- or glibenclamide-sensitive K-channels is less likely involved in reactive hyperemia.  (+info)

NAD(+)-dependent (S)-specific secondary alcohol dehydrogenase involved in stereoinversion of 3-pentyn-2-ol catalyzed by Nocardia fusca AKU 2123. (8/688)

An NAD(+)-dependent alcohol dehydrogenase was purified to homogeneity from Nocardia fusca AKU 2123. The enzyme catalyzed (S)-specific oxidation of 3-pentyn-2-ol (PYOH), i.e., part of the stereoinversion reaction for the production of (R)-PYOH, which is a valuable chiral building block for pharmaceuticals, from the racemate. The enzyme used a broad variety of secondary alcohols including alkyl alcohols, alkenyl alcohols, acetylenic alcohols, and aromatic alcohols as substrates. The oxidation was (S)-isomer specific in every case. The K(m) and Vmax for (S)-PYOH and (S)-2-hexanol oxidation were 1.6 mM and 53 mumol/min/mg, and 0.33 mM and 130 mumol/min/mg, respectively. The enzyme also catalyzed stereoselective reduction of carbonyl compounds. (S)-2-Hexanol and ethyl (R)-4-chloro-3-hydroxybutanoate in high optical purity were produced from 2-hexanone and ethyl 4-chloro-3-oxobutanoate by the purified enzyme, respectively. The K(m) and Vmax for 2-hexanone reduction were 2.5 mM and 260 mumol/min/mg. The enzyme has a relative molecular mass of 150,000 and consists of four identical subunits. The NH2-terminal amino acid sequence of the enzyme shows similarity with those of the carbonyl reductase from Rhodococcus erythropolis and phenylacetaldehyde reductase from Corynebacterium sp.  (+info)

organic chemistry - Correct definition of terminal alkynes? - Chemistry Stack Exchangeorganic chemistry - Correct definition of terminal alkynes? - Chemistry Stack Exchange
Youre right; the definition in your book is simplistic. A terminal alkyne would be better defined as an alkyne with the formula $\ce{RC_2H}$, differentiating from an internal alkyne, which would have the formula $\ce{RC_2R}$ and the added stipulation that neither R nor R can be a hydrogen. Equivalently stated as in Wikipedia, an internal alkyne has carbon substitutents on all acetylenic carbons, and a terminal alkyne is therefore not an internal alkyne because at least one acetylenic carbon has a hydrogen bonded to it.. The example formula you cite is vinylacetylene, systematic name butenyne or 1-buten-3-yne (heres your IUPAC nomenclature rules favoring double bonds at work; otherwise itd be ethynylbutene or similar). It is indeed an example of a terminal alkyne, having the exploded formula (C2H3)C2H.. ...
https://chemistry.stackexchange.com/questions/4854/correct-definition-of-terminal-alkynes
Evaluation of biofilm formation on novel copper-catalyzed azide-alkyne cycloaddition (CuAAC)-based resins for dental...Evaluation of biofilm formation on novel copper-catalyzed azide-alkyne cycloaddition (CuAAC)-based resins for dental...
Evaluation of biofilm formation on novel copper-catalyzed azide-alkyne cycloaddition (CuAAC)-based resins for dental restoratives Journal Article ...
https://experts.colorado.edu/display/pubid_233880
Hydrosilylation of alkynes catalysed by platinum on titania<...Hydrosilylation of alkynes catalysed by platinum on titania<...
TY - JOUR. T1 - Hydrosilylation of alkynes catalysed by platinum on titania. AU - Alonso, Francisco. AU - Buitrago, Robison. AU - Moglie, Yanina. AU - Ruiz-Martínez, Javier. AU - Sepúlveda-Escribano, Antonio. AU - Yus, Miguel. N1 - Generated from Scopus record by KAUST IRTS on 2019-08-08. PY - 2011/1/1. Y1 - 2011/1/1. N2 - The heterogeneous hydrosilylation of alkynes catalysed by platinum on titania is reported. A variety of hydrosilanes react with both terminal and internal alkynes to furnish the corresponding vinyl silanes in high yields and short reaction times as well as in a regio- and stereoselective manner. The catalyst can be easily recovered and reused in several consecutive cycles. © 2010 Elsevier B.V. All rights reserved.. AB - The heterogeneous hydrosilylation of alkynes catalysed by platinum on titania is reported. A variety of hydrosilanes react with both terminal and internal alkynes to furnish the corresponding vinyl silanes in high yields and short reaction times as well as ...
https://research.kaust.edu.sa/en/publications/hydrosilylation-of-alkynes-catalysed-by-platinum-on-titania
Rhodium-catalyzed oxidative cycloaddition of benzamides and alkynes via C-H/N-H activation<...Rhodium-catalyzed oxidative cycloaddition of benzamides and alkynes via C-H/N-H activation<...
TY - JOUR. T1 - Rhodium-catalyzed oxidative cycloaddition of benzamides and alkynes via C-H/N-H activation. AU - Hyster, Todd K.. AU - Rovis, Tomislav. PY - 2010/8/4. Y1 - 2010/8/4. N2 - The oxidative cycloaddition of benzamides and alkynes has been developed. The reaction utilizes Rh(III) catalysts in the presence of Cu(II) oxidants, and is proposed to proceed by N-H metalation of the amide followed by ortho C-H activation. The resultant rhodacycle undergoes alkyne insertion to form isoquinolones in good yield. The reaction is tolerant of extensive substitution on the amide, alkyne, and arene, including halides, silyl ethers, and unprotected aldehydes as substituents. Unsymmetrical alkynes proceed with excellent regioselectivity, and heteroaryl carboxamides are tolerated leading to intriguing scaffolds for medicinal chemistry. A series of competition experiments shed further light on the mechanism of the transformation and reasons for selectivity.. AB - The oxidative cycloaddition of benzamides ...
https://collaborate.princeton.edu/en/publications/rhodium-catalyzed-oxidative-cycloaddition-of-benzamides-and-alkyn
Rhodium(III)-Catalyzed Annulation of 4-Phenylquinazolines with internal Alkynes via Dual C−H Bond Functionalization - raiithRhodium(III)-Catalyzed Annulation of 4-Phenylquinazolines with internal Alkynes via Dual C−H Bond Functionalization - raiith
Rh(III)-catalyzed C−H bond annulation with alkynes has excogitated into a potent method for the preparation of highly substituted polycyclic aromatic and heteroaromatic compounds. Here Rh(III)-catalyzed annulation of 4-phenyl quinazolines with internal alkynes via dual C−H bond activation has been explored. The synthetic procedure has the advantages of high efficiency and functional group tolerance, excellent regioselectivity and broad substrate scope under mild conditions and some of the resulting products exhibit intense fluorescence in the solution state. Such structural motifs may important precursors for further transformations into biologically active compounds & π-conjugated functional materials such as organic semiconductors and luminescent materials which have broad prospect in future life.. ...
http://raiith.iith.ac.in/5714/
Ruthenium-Catalyzed Cross Coupling Reactions of Alkynes and Alkenes by Yuzhong ChenRuthenium-Catalyzed Cross Coupling Reactions of Alkynes and Alkenes by Yuzhong Chen
Transition-metal-mediated cross coupling reaction of alkynes and alkenes has recently gained increasing significance in organic chemistry because it represents an efficient method for the formation of new carbon-carbon bond. In recent years, two types of the coupling reactions have been developed: intramolecular couplings of enynes and intermolecular couplings of alkynes and alkenes. These results were classified into two mechanistic pathways, one not involving carbon-carbon bond cleavage, insertion mechanism, and the other involving carbon-carbon bond cleavage, metathesis mechanism. While the coupling reactions of alkynes with substituted alkenes have been well developed, there are very few reports on the coupling of alkynes with the simplest alkene, ethylene documented in the literature. Our research goal is to develop a new rutheniumbased system to study the coupling reactions of alkynes with ethylene, and extend its scope to enyne and substituted alkenes.
https://epublications.marquette.edu/theses/2433/
Well-defined (co)polypeptides bearing pendant alkyne groups<...Well-defined (co)polypeptides bearing pendant alkyne groups<...
TY - JOUR. T1 - Well-defined (co)polypeptides bearing pendant alkyne groups. AU - Zhao, Wei. AU - Gnanou, Yves. AU - Hadjichristidis, Nikos. N1 - KAUST Repository Item: Exported on 2020-10-01 Acknowledgements: The research reported in this publication was supported by funding from King Abdullah University of Science and Technology (KAUST).. PY - 2016. Y1 - 2016. N2 - A novel metal-free strategy, using hydrogen-bonding catalytic ring opening polymerization of acetylene-functionalized N-carboxy anhydrites of α-amino acids, was developed for the synthesis of well-defined polypeptides bearing pendant alkyne groups. This method provides an efficient way to synthesize novel alkyne-functionalized homopolypeptides (A) and copolypeptides, such as AB diblock (B: non-functionalized), ABA triblock and star-AB diblock, as well as linear and star random copolypeptides, precursors of a plethora complex macromolecular architectures by click chemistry.. AB - A novel metal-free strategy, using hydrogen-bonding ...
https://research.kaust.edu.sa/en/publications/well-defined-copolypeptides-bearing-pendant-alkyne-groups
Synthesis of Isoquinolines from α-Aryl Vinyl Azides and Internal Alkynes by Rh-Cu Bimetallic Cooperation - Wang - 2011 -...Synthesis of Isoquinolines from α-Aryl Vinyl Azides and Internal Alkynes by Rh-Cu Bimetallic Cooperation - Wang - 2011 -...
Wang, Y.-F., Toh, K. K., Lee, J.-Y. and Chiba, S. (2011), Synthesis of Isoquinolines from α-Aryl Vinyl Azides and Internal Alkynes by Rh-Cu Bimetallic Cooperation. Angew. Chem., 123: 6049-6053. doi: 10.1002/ange.201101009 ...
http://onlinelibrary.wiley.com/doi/10.1002/ange.201101009/suppinfo
Alkyne synonyms, alkyne antonyms - FreeThesaurus.comAlkyne synonyms, alkyne antonyms - FreeThesaurus.com
Synonyms for alkyne in Free Thesaurus. Antonyms for alkyne. 2 synonyms for alkyne: acetylene, ethyne. What are synonyms for alkyne?
https://www.freethesaurus.com/alkyne
C1-Symmetric RhPhebox-Catalyzed Asymmetric Alkynylation of -Ketoesters.C1-Symmetric RhPhebox-Catalyzed Asymmetric Alkynylation of -Ketoesters.
Communications DOI: 10.1002/anie.201100252 Asymmetric Catalysis C1-Symmetric Rh/Phebox-Catalyzed Asymmetric Alkynylation of a-Ketoesters** Takashi Ohshima,* Takahito Kawabata, Yosuke Takeuchi, Takahiro Kakinuma, Takanori Iwasaki, Takayuki Yonezawa, Hajime Murakami, Hisao Nishiyama, and Kazushi Mashima* Catalytic asymmetric alkynylation of carbonyl compounds is one of the most efficient routes for the synthesis of optically active propargylic alcohols, which are useful and versatile building blocks for a variety of functionalized molecules, such as biologically active natural products.[1] In the initial stages of development of this transformation, stoichiometric amounts of metal reagents such as organolithium, organomagnesium, and diorganozinc compounds were used to increase the nucleophilicity of the alkyne and to prevent an undesired retro reaction.[1, 2] In terms of atom economy,[3] however, the direct in situ generation of a metal alkynylide species from terminal alkynes using a catalytic ...
https://www.docme.ru/doc/1911590/c1-symmetric-rhphebox-catalyzed-asymmetric-alkynylation-o..
Zinc-Catalysed Hydroboration of Terminal and Internal Alkynes ePrints@IIScZinc-Catalysed Hydroboration of Terminal and Internal Alkynes [email protected]
A regioselective hydroboration of alkynes has been developed by using commercially available zinc triflate as a catalyst, in the presence of catalytic amount of NaBHEt3. The reaction tolerates a wide range of terminal alkynes having several synthetically useful functional groups and proceeds regioselectively to furnish hydroborated products in moderate to excellent yields. This system shows moderate chemoselectivity towards terminal C equivalent to C bond over terminal and internal C=C bond and internal C equivalent to C bond.. ...
http://eprints.iisc.ac.in/63524/
Diversified polyoxovanadate derivatives obtained by copper(i)-catalysed azide-alkyne cycloaddition reaction: their synthesis...Diversified polyoxovanadate derivatives obtained by copper(i)-catalysed azide-alkyne cycloaddition reaction: their synthesis...
In this work, we confirmed that the copper-catalysed azide-alkyne cycloaddition (CuAAC) reaction is an effective method for the organic-functionalization of polyoxometalates (POMs). Herein, for the first time, four novel 1,2,3-triazole functionalized polyoxovanadate (POV) organic-inorganic hybrids, (Bu4N)2[V6O13{(O
http://pubs.rsc.org/en/content/articlelanding/2017/dt/c7dt03822d
A new sinthetic application of (dichloroiodo)benzene in reactions with alkenes and alkynes<...A new sinthetic application of (dichloroiodo)benzene in reactions with alkenes and alkynes<...
TY - GEN. T1 - A new sinthetic application of (dichloroiodo)benzene in reactions with alkenes and alkynes. AU - Yusubova, R. J.. AU - Filimonov, V. D.. AU - Yusubov, M. S.. AU - Chi, Ki Whan. PY - 2004. Y1 - 2004. N2 - A convenient synthesis of vicinal methoxychlorides, methoxyiodides from alkenes and alkynes using PhICl2/CH3OH, I 2/PhICl2/CH3OH is described.. AB - A convenient synthesis of vicinal methoxychlorides, methoxyiodides from alkenes and alkynes using PhICl2/CH3OH, I 2/PhICl2/CH3OH is described.. KW - (dichloroiodo)Benzene. KW - Alkenes. KW - Alkynes. KW - Chloromethoxylation. KW - Iodomethoxylation. UR - http://www.scopus.com/inward/record.url?scp=29144459782&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=29144459782&partnerID=8YFLogxK. M3 - Conference contribution. AN - SCOPUS:29144459782. SN - 0780383834. SN - 9780780383838. VL - 2. SP - 97. EP - 98. BT - 8th Korea-Russia International Symposium on Science and Technology - Proceedings: KORUS 2004. ER - ...
https://tpu.pure.elsevier.com/ru/publications/a-new-sinthetic-application-of-dichloroiodobenzene-in-reactions-w
New oxidative transformations of alkenes and alkynes under the action of diacetoxyiodobenzene<...New oxidative transformations of alkenes and alkynes under the action of diacetoxyiodobenzene<...
TY - JOUR. T1 - New oxidative transformations of alkenes and alkynes under the action of diacetoxyiodobenzene. AU - Yusubov, M. S.. AU - Zholobova, G. A.. AU - Filimonova, I. L.. AU - Chi, Ki Whan. PY - 2004/8/1. Y1 - 2004/8/1. N2 - Treatment of alkenes and alkynes with diacetoxyiodobenzene activated by mineral and organic acids predominantly results in oxidative rearrangement. 1,4-Diphenylbutadiene in MeOH gives 3,4-dimethoxy-1,4-diphenylbut-1-ene.. AB - Treatment of alkenes and alkynes with diacetoxyiodobenzene activated by mineral and organic acids predominantly results in oxidative rearrangement. 1,4-Diphenylbutadiene in MeOH gives 3,4-dimethoxy-1,4-diphenylbut-1-ene.. KW - Alkenes. KW - Alkynes. KW - Diacetoxyiodobenzene. KW - Oxidative rearrangement. KW - Polyvalent iodine compounds. UR - http://www.scopus.com/inward/record.url?scp=14944340734&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=14944340734&partnerID=8YFLogxK. U2 - 10.1007/s11172-005-0027-8. DO - ...
https://tpu.pure.elsevier.com/en/publications/new-oxidative-transformations-of-alkenes-and-alkynes-under-the-ac
Chemical Properties Of The Alkynes | Alkyne Assignment Help | Alkyne Homework Help | Homework For AlkyneChemical Properties Of The Alkynes | Alkyne Assignment Help | Alkyne Homework Help | Homework For Alkyne
Best Chemical Properties Of The Alkynes Online Homework Help, Assignment Help providers on internet. 24 X 7 live online tutoring at Assignmenthelp.net.
http://www.assignmenthelp.net/assignment_help/chemical-properties-of-the-alkynes
Synthesis of Strained 1,3-Diene Macrocycles via Copper-Mediated Castro-Stephens Coupling/Alkyne Reduction Tandem Reactions<...Synthesis of Strained 1,3-Diene Macrocycles via Copper-Mediated Castro-Stephens Coupling/Alkyne Reduction Tandem Reactions<...
TY - JOUR. T1 - Synthesis of Strained 1,3-Diene Macrocycles via Copper-Mediated Castro-Stephens Coupling/Alkyne Reduction Tandem Reactions. AU - Li, Wei. AU - Schneider, Christopher M.. AU - Georg, Gunda I.. PY - 2015/8/7. Y1 - 2015/8/7. N2 - A copper-mediated macrocyclization involving the reaction of a vinyl iodide and a terminal alkyne followed by an in situ reduction of the enyne intermediate is reported. The reaction generates a conjugated Z-double bond within a strained medium-size lactone, lactam, or ether macrocycle. A variety of macrocyclic compounds bearing different ring sizes and functionalities were synthesized. A complementary stepwise procedure was also developed for less strained ring systems.. AB - A copper-mediated macrocyclization involving the reaction of a vinyl iodide and a terminal alkyne followed by an in situ reduction of the enyne intermediate is reported. The reaction generates a conjugated Z-double bond within a strained medium-size lactone, lactam, or ether ...
https://minnesota-staging.pure.elsevier.com/en/publications/synthesis-of-strained-13-diene-macrocycles-via-copper-mediated-ca
Guanidine) copper complex-catalyzed enantioselective dynamic kinetic allylic alkynylation under biphasic condition | DR-NTUGuanidine) copper complex-catalyzed enantioselective dynamic kinetic allylic alkynylation under biphasic condition | DR-NTU
Highly enantioselective allylic alkynylation of racemic bromides under biphasic condition is furnished in this report. This approach employs functionalized terminal alkynes as pro-nucleophiles and provides 6- and 7-membered cyclic 1,4-enynes with high yields and excellent enantioselectivities (up to 96% ee) under mild conditions. Enantioretentive derivatizations highlight the synthetic utility of this transformation. Cold-spray ionization mass spectrometry (CSI-MS) and X-ray crystallography were used to identify some catalytic intermediates, which include guanidinium cuprate ion pairs and a copper-alkynide complex. A linear correlation between the enantiopurity of the catalyst and reaction product indicates the presence of a copper complex bearing a single guanidine ligand at the enantio-determining step. Further experimental and computational studies supported that the alkynylation of allylic bromide underwent an anti-SN2 pathway catalyzed by nucleophilic cuprate species. Moreover, ...
https://dr.ntu.edu.sg/handle/10356/137033
Bismuth(III)-Catalyzed hydration of terminal alkynes: Sustainable synthesis of methyl ketones in batch and flow<...Bismuth(III)-Catalyzed hydration of terminal alkynes: Sustainable synthesis of methyl ketones in batch and flow<...
TY - JOUR. T1 - Bismuth(III)-Catalyzed hydration of terminal alkynes. T2 - Sustainable synthesis of methyl ketones in batch and flow. AU - Ötvös, Sándor B.. AU - Szécsényi, Zsanett. AU - Fülöp, F.. PY - 2019/8/5. Y1 - 2019/8/5. N2 - Environmentally benign synthesis of methyl ketones is demonstrated via unprecedented bismuth(III)-catalyzed activation and Markovnikov-type hydration of terminal acetylenes. Besides a batch process operating under reasonably mild conditions, a chemically intensified high-temperature continuous-flow methodology has also been developed using a coil reactor. The preparative capabilities of the flow process were demonstrated with multigram-scale alkyne hydrations. The methods presented rely on readily available bismuth(III) salts as green catalysts and exhibit less environmental concerns than earlier methods.. AB - Environmentally benign synthesis of methyl ketones is demonstrated via unprecedented bismuth(III)-catalyzed activation and Markovnikov-type hydration ...
https://hungary.pure.elsevier.com/hu/publications/bismuthiii-catalyzed-hydration-of-terminal-alkynes-sustainable-sy
Alkynes Are A Blank CanvasAlkynes Are A Blank Canvas
Acetylene is the ultimate carbon building block (on paper, anyway!). It bears two relatively acidic C-H bonds (pKa 25) and can therefore be alkylated (i.e. deprotonated to give its conjugate base, then treated with an alkyl halide) on either end giving either a mono-substituted (also known as a terminal alkyne) or di-substituted (internal) alkyne as desired. This is important because in first semester organic chemistry, this reaction represents an important means of extending the carbon chain. You dont learn that many reactions that form C-C. This reaction comes up a lot ...
https://staging.masterorganicchemistry.com/2013/06/24/alkynes-are-a-blank-canvas/
PPT - Alkynes Chapters 7,8 PowerPoint Presentation - ID:171874PPT - Alkynes Chapters 7,8 PowerPoint Presentation - ID:171874
Outline1. Bonding in alkynes. sp-Hybridization2. Physical properties and nomenclature of alkynes 3. Preparation and use of alkynes4. Addition to triple bonds. Hydrohalogenation5. Addition to triple bonds. Hydration6. Addition to triple bonds. Hydroboration-oxidation7. Addition to triple bonds....
https://www.slideserve.com/omer/alkynes-chapters-7-8
9. Alkynes: An Introduction to Organic Synthesis - ppt video online download9. Alkynes: An Introduction to Organic Synthesis - ppt video online download
Alkynes Hydrocarbons that contain carbon-carbon triple bonds C≡C Acetylene, the simplest alkyne is produced industrially from methane and steam at high temperature Our study of alkynes provides an introduction to organic synthesis, the preparation of organic molecules from simpler organic molecules
http://slideplayer.com/slide/4335432/
Hydrofluoroarylation of alkynes with fluoroarenes<...Hydrofluoroarylation of alkynes with fluoroarenes<...
TY - JOUR. T1 - Hydrofluoroarylation of alkynes with fluoroarenes. AU - Kanyiva, Stephen Kyalo. AU - Kashihara, Natsuko. AU - Nakao, Yoshiaki. AU - Hiyama, Tamejiro. AU - Ohashi, Masato. AU - Ogoshi, Sensuke. PY - 2010/11/21. Y1 - 2010/11/21. N2 - A combination of Ni(cod)2 and PCyp3 is found to be an effective catalyst for chemoselective activation of the C-H bond of fluoroarenes over C-F bonds followed by insertion of alkynes to allow direct alkenylation of the electron-deficient arenes. The characteristics of the reactions are: a C-H bond ortho to a fluorine substituent is selectively activated; the reactivity of fluorobenzenes is roughly proportional to the number of fluorine atoms. The reaction conditions tolerate a broad range of both alkynes and fluoroarenes containing both electron-withdrawing and -donating groups, thus allowing efficient synthesis of a variety of substituted ethenes containing a fluoroaryl motif in high regio- and stereoselective manners. Mechanistic studies including ...
https://waseda.pure.elsevier.com/en/publications/hydrofluoroarylation-of-alkynes-with-fluoroarenes
A strategy for conditional orthogonal sequential CuAAC reactions using a protected aromatic ynamine<...A strategy for conditional orthogonal sequential CuAAC reactions using a protected aromatic ynamine<...
TY - JOUR. T1 - A strategy for conditional orthogonal sequential CuAAC reactions using a protected aromatic ynamine. AU - Hatit, Marine Z. C.. AU - Seath, Ciaran P.. AU - Watson, Allan J. B.. AU - Burley, Glenn A.. N1 - This document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal of Organic Chemistry, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.joc.7b00545.. PY - 2017/4/28. Y1 - 2017/4/28. N2 - A method for conditional control of orthogonal sequential Cu-catalyzed azide alkyne cycloaddition (CuAAC) reactions is reported. The inherent reactivity of an aromatic ynamine is controlled by a silyl protecting group that allows the selective CuAAC reaction of less reactive alkynes. Alternatively, the same protected ynamine undergoes selective CuAAC reaction via silyl deprotection in situ to give theynamine click products. This ...
https://pureportal.strath.ac.uk/en/publications/a-strategy-for-conditional-orthogonal-sequential-cuaac-reactions-
the type of hybridization in alkynes isthe type of hybridization in alkynes is
This has some implications in the properties and chemical reactivity of sigma and pi bonds. Ethyne or acetylene, HC=CH, is the simplest alkyne example. The process for understanding the sp hybridization process for carbon is basically an extension of the other two types (sp 3 and sp 2). Thus, in acetylene (ethyne), there are two unhybridized orbitals, which, by convention are and (see figure below): Figure: Illustrating the sp orbitals. The triple bonded carbon atoms of acetylene aresp hybridized. The sigma bond is short and strong. E)An alkyne reacts as an electrophile,and is therefore electron poor. Type of â ¦ You should try to work out this scheme on your own and see if your predictions agree with those presented in the textbook. is related to Unsaturated Hydrocarbons Quiz. The Structure of Ethyne (Acetylene): sp Hybridization ** Hydrocarbons in which two carbon atoms share three pairs of electrons between them, and are thus bonded by a triple bond, are called alkynes. Correspondingly, ...
http://worthytravel.com/xke1mp2/the-type-of-hybridization-in-alkynes-is-2fbe38
Highly Chemo- and Stereoselective Transfer Semihydrogenation of Alkynes Catalyzed by a Stable, Well-Defined Manganese(II)...Highly Chemo- and Stereoselective Transfer Semihydrogenation of Alkynes Catalyzed by a Stable, Well-Defined Manganese(II)...
Herein we report unprecedented manganese-catalyzed semihydrogenation of internal alkynes to (Z)-alkenes using ammonia borane as a hydrogen donor. The reaction is catalyzed by a pincer complex of the earth-abundant manganese(II) salt in the absence of any additives, base, or superhydride. The ammonia borane smoothly reduces the manganese precatalyst [Mn(II)-PNP][Cl]2 to the catalytically active species [Mn(I)-PNP]-hydride in the triplet spin state. This manganese hydride is highly stabilized by complexation with the alkyne substrate. Computational density functional theory (DFT) analysis studies of the reaction mechanism rationalize the origin of stereoselectivity toward formation of (Z)-alkenes ...
https://accedacris.ulpgc.es/handle/10553/74774
Buy Alkyne functionalized | Alkyne functionalized Online : MKNano.comBuy Alkyne functionalized | Alkyne functionalized Online : MKNano.com
Alkyne functionalized Single layer graphene Flake size: 0.5-5 microns. Thickness: Single atomic layer >80% Purity: Carbon contents over 80% Alkyne functionalized online from Mknano.com.
http://mknano.com/Graphene-Fullerenes/Graphene/Functionalized-Single-Layer-Graphene-in-Aqueous-Solution/Alkyne-functionalized
Alkynes and Their Reactions - PDFAlkynes and Their Reactions - PDF
Alkynes and Their Reactions Naming Alkynes Alkynes are named in the same general way that alkenes are named. In the IUPAC system, change the ane ending of the parent alkane name to the suffix yne. Choose
http://docplayer.net/22407690-Alkynes-and-their-reactions.html
PPT - ALKYnes sem 1: 2011/2012 PowerPoint Presentation - ID:2192169PPT - ALKYnes sem 1: 2011/2012 PowerPoint Presentation - ID:2192169
ALKYnes sem 1: 2011/2012. Khadijah Hanim bt Abdul Rahman School of Bioprocess Engineering, UniMAP Week 5: 13/10/2011 [email protected] Learning outcomes. Structure, nomenclature and naming alkynes DEFINE and ILLUSTRATE the principle in naming alkynes on few examples...
https://www.slideserve.com/lucian/alkynes-sem-1-2011-2012
Completely regioselective insertion of unsymmetrical alkynes into electron-deficient alkenes for the synthesis of new...Completely regioselective insertion of unsymmetrical alkynes into electron-deficient alkenes for the synthesis of new...
A Lewis acid-catalyzed insertion of unsymmetrical alkynes into electron-deficient alkenes was developed for the first time, and used to produce 34 hitherto unreported pentacyclic benzo[5,6]chromeno[2,3-b]indoles with generally good yields and complete stereoselectivity. A Yb(OTf)3-catalyzed reaction between
https://pubs.rsc.org/en/content/articlelanding/2019/cc/c9cc08762a/unauth
Learning CHEMISTRY for IIT JEE: JEE 2008 Organic Chemistry SyllabusLearning CHEMISTRY for IIT JEE: JEE 2008 Organic Chemistry Syllabus
Preparation, properties and reactions of alkenes and alkynes: Physical properties of alkenes and alkynes (boiling points, density and dipole moments); Acidity of alkynes; Acid catalysed hydration of alkenes and alkynes (excluding the stereochemistry of addition and elimination); Reactions of alkenes with KMnO4 and ozone; Reduction of alkenes and alkynes; Preparation of alkenes and alkynes by elimination reactions; Electrophilic addition reactions of alkenes with X2, HX, HOX and H2O (X=halogen); Addition reactions of alkynes; Metal acetylides ...
http://iit-jee-chemistry.blogspot.com/2007/12/jee-2008-organic-chemistry-syllabus.html
JAIRO | Rhodium-Catalyzed Intermolecular Alkyne Cyclotrimerization Route to a Functionalized CycloparaphenyleneJAIRO | Rhodium-Catalyzed Intermolecular Alkyne Cyclotrimerization Route to a Functionalized Cycloparaphenylene
Rhodium-Catalyzed Intermolecular Alkyne Cyclotrimerization Route to a Functionalized CycloparaphenyleneRhodium-Catalyzed Intermolecular Alkyne Cyclotrimerization Route to a Functionalized Cycloparaphenylene ...
http://jairo.nii.ac.jp/0083/00229021/en
中国科学院上海有机化学研究所机构知识库(SIOC OpenIR): Metal-Free Oxidative Trifluoromethylthiolation of Terminal Alkynes with CF3SiMe3 and...中国科学院上海有机化学研究所机构知识库(SIOC OpenIR): Metal-Free Oxidative Trifluoromethylthiolation of Terminal Alkynes with CF3SiMe3 and...
A metal-free oxidative trifluoromethyl-thiolation of terminal alkynes using readily available CF3SiMe3 and elemental sulfur at room temperature has been developed. This reaction provides an efficient and convenient method for the preparation of alkynyl trifluoromethyl sulfides bearing a wide range of functional groups. Preliminary investigation revealed that elemental sulfur instead of air acted as the oxidant ...
http://ir.sioc.ac.cn/handle/331003/28325
Dual Inhibition of Mycobacterial Fatty Acid Biosynthesis and Degradation by 2-Alkynoic Acids<...Dual Inhibition of Mycobacterial Fatty Acid Biosynthesis and Degradation by 2-Alkynoic Acids<...
TY - JOUR. T1 - Dual Inhibition of Mycobacterial Fatty Acid Biosynthesis and Degradation by 2-Alkynoic Acids. AU - Morbidoni, Hector R.. AU - Vilchèze, Catherine. AU - Kremer, Laurent. AU - Bittman, Robert. AU - Sacchettini, James C.. AU - Jacobs, William R.. N1 - Funding Information: H.R.M. is a Career Investigator of Consejo de Investigaciones de la Universidad Nacional de Rosario (CIURN), Argentina. This work was supported by National Institutes of Health grant AI43268. L.K. is supported by a grant from the Centre National de la Recherche Scientifique (Actions Thématiques et Incitatives sur Programmes Microbiologie Fondamentale).. PY - 2006/3. Y1 - 2006/3. N2 - 2-Hexadecynoic acid and 2-octadecynoic acid have cidal activity against Mycobacterium smegmatis and Mycobacterium bovis BCG. At subinhibitory concentrations, M. smegmatis rapidly transformed [1-14C]-2-hexadecynoic acid into endogenous fatty acids and elongated them into mycolic acids. Toxic concentrations of 2-hexadecynoic acid ...
https://einstein.pure.elsevier.com/en/publications/dual-inhibition-of-mycobacterial-fatty-acid-biosynthesis-and-degr
Catalytic Enantioselective Addition of Terminal Alkynes to Aldehydes: Preparation of (S)-(-)-1,3-Diphenyl-2-Propyn-1-ol and (S)...Catalytic Enantioselective Addition of Terminal Alkynes to Aldehydes: Preparation of (S)-(-)-1,3-Diphenyl-2-Propyn-1-ol and (S)...
TY - JOUR. T1 - Catalytic Enantioselective Addition of Terminal Alkynes to Aldehydes: Preparation of (S)-(-)-1,3-Diphenyl-2-Propyn-1-ol and (S)-(-)-4-Methyl-1-Phenyl-2-Pentyn-1,4-Diol. AU - Takita, Ryo. AU - Harada, Shinji. AU - Ohshima, Takashi. AU - Matsunaga, Shigeki. AU - Shibasaki, Masakatsu. PY - 2008. Y1 - 2008. U2 - 10.1002/0471264229.os085.13. DO - 10.1002/0471264229.os085.13. M3 - Article. VL - 85. JO - Organic Syntheses. JF - Organic Syntheses. SN - 0078-6209. ER - ...
https://kyushu-u.pure.elsevier.com/en/publications/catalytic-enantioselective-addition-of-terminal-alkynes-to-aldehy-2
Development of Acid, Silver, and Solvent-Free Gold-Catalyzed Hydroelem by Daniel Vincent FraccicaDevelopment of Acid, Silver, and Solvent-Free Gold-Catalyzed Hydroelem by Daniel Vincent Fraccica
ABSTRACT FOR PART I: HYDROPHENOXYLATION REACTIONS CATALYZED BY ARYLGOLD(I) COMPOUNDS Both carbine and phosphine ligated arylgold(I) compounds have been synthesized and investigated as single-component catalysts for the hydrophenoxylation of unactivated internal alkynes to yield vinyl ethers. Catalysts containing either JohnPhos or IPr/SIPr were found to be the most efficient catalysts during the screening process. Electron-withdrawing and electron-donating groups on the phenols were tolerated using these catalysts. No silver salts, acids, or solvents were needed for the catalysis, and either microwave or conventional heating afforded moderate to excellent yields of the vinyl ethers. ABSTRACT FOR PART II: ARYLGOLD(I) COMPOUNDS TO PROMOTE THE ADDITION OF DIPHENYLPHOSPHINIC ACID TO TERMINAL ALKYNES Arylgold compounds were investigated as single component catalysts for the addition of diphenylphosphinic acid to terminal alkynes using a microwave reactor. Both carbene and phosphine ligated compounds were
https://digitalcommons.bucknell.edu/masters_theses/133/
hydration of alkyneshydration of alkynes
A mild strategy for highly regioselective hydration of the alkynes (internal and terminal) has been developed employing intramolecular ketone as the directing group under Ag(I) catalysis. were using acid to catalyze this transition. For terminal alkynes the addition of water follows the Markovnikov rule, as in the second example below, and the final product ia a methyl ketone ( except for acetylene, shown in the first example ). And then we have H2O and H2SO4 are If youre seeing this message, it means were having trouble loading external resources on our website. So this is my enol form. see a very similar reaction where we do a base-catalyzed mechanism for this arrangement in a few minutes here. Now the equilibrium is actually In contrast, the indirect hydration by the reaction sequence of hydroboration, oxidation and hydrolysis results in the anti-Markovnikov product. acid-catalyzed tautomerization. The first step is an acid/base reaction where the π electrons of the triple bond acts as a ...
https://diobeth.org/.tmb/forum/hwb0oig.php?e0ffba=hydration-of-alkynes
Phosphoramidate-Assisted Alkyne Activation: Probing the Mechanism of Proton Shuttling in a N,O-Chelated Cp*Ir(III) Complex |...Phosphoramidate-Assisted Alkyne Activation: Probing the Mechanism of Proton Shuttling in a N,O-Chelated Cp*Ir(III) Complex |...
Ligand lability offers a unique opportunity for access to metal-ligand cooperativity (MLC), helping to direct new organometallic and catalytic reactions. In recent years, ligand-assisted C-H bond activation and, more generally, proton migration have been of particular interest. This paper describes a detailed computational study into the mechanism, as well as the region and stereoselectivity, observed in a recently reported transformation where MLC in a 16-electron iridium(III) phosphoramidate complex plays a critical role in directing the activation of terminal alkynes toward the generation of novel five-membered (E)-vinyloxyirida(III)cycles. Five possible pathways for the formation of such products were investigated. Based on our findings, it is proposed that the reaction proceeds via a ligand-assisted proton shuttle (LAPS) mechanism, where the phosphoramidate phosphoryl (P=O) group assists in both alkyne C-H bond activation and C-H bond formation to form a vinylidene intermediate. Next, C-O ...
https://www.chem.ubc.ca/phosphoramidate-assisted-alkyne-activation-probing-mechanism-proton-shuttling-no-chelated-cpiriii
Grafting of poly(ethylene glycol) on click chemistry modified Si(100) surfacesGrafting of poly(ethylene glycol) on click chemistry modified Si(100) surfaces
Poly(ethylene glycol) (PEG) is one of the most extensively studied antifouling coatings due to its ability to reduce protein adsorption and improve biocompatibility. Although the use of PEG for antifouling coatings is well established, the stability and density of PEG layers are often inadequate to provide optimum antifouling properties. To improve on these shortcomings, we employed the stepwise construction of PEG layers onto a silicon surface. Acetylene-terminated alkyl monolayers were attached to nonoxidized crystalline silicon surfaces via a one-step hydrosilylation procedure with 1,8-nonadiyne. The acetylene-terminated surfaces were functionalized via a copper-catalyzed azide-alkyne cycloaddition (CuAAC) reaction of the surface-bound alkynes with an azide to produce an amine terminated layer. The amine terminated layer was then further conjugated with PEG to produce an antifouling surface. The antifouling surface properties were investigated by testing adsorption of human serum albumin ...
https://espace.curtin.edu.au/handle/20.500.11937/36024
Alkyne - WikipediaAlkyne - Wikipedia
In systematic chemical nomenclature, alkynes are named with the Greek prefix system without any additional letters. Examples include ethyne or octyne. In parent chains with four or more carbons, it is necessary to say where the triple bond is located. For octyne, one can either write 3-octyne or oct-3-yne when the bond starts at the third carbon. The lowest number possible is given to the triple bond. When no superior functional groups are present, the parent chain must include the triple bond even if it is not the longest possible carbon chain in the molecule. Ethyne is commonly called by its trivial name acetylene.. In chemistry, the suffix -yne is used to denote the presence of a triple bond. In organic chemistry, the suffix often follows IUPAC nomenclature. However, inorganic compounds featuring unsaturation in the form of triple bonds may be denoted by substitutive nomenclature with the same methods used with alkynes (i.e. the name of the corresponding saturated compound is modified by ...
https://en.wikipedia.org/wiki/Alkyne
Copper-catalyzed oxidative [2 + 2 + 1] cycloaddition: regioselective synthesis of 1,3-oxazoles from internal alkynes and...Copper-catalyzed oxidative [2 + 2 + 1] cycloaddition: regioselective synthesis of 1,3-oxazoles from internal alkynes and...
A free platform for explaining your research in plain language, and managing how you communicate around it - so you can understand how best to increase its impact.
https://www.growkudos.com/publications/10.1039%25252Fc2sc21041j/reader
中国科学院大连化学物理研究所机构知识库(DICP OpenIR): Mild and Efficient Ir(III)-Catalyzed Direct C−H Alkynylation of N‑Phenoxyacetamides with...中国科学院大连化学物理研究所机构知识库(DICP OpenIR): Mild and Efficient Ir(III)-Catalyzed Direct C−H Alkynylation of N‑Phenoxyacetamides with...
Jie Zhou,Jingjing Shi,Qi ZS,et al. Mild and Efficient Ir(III)-Catalyzed Direct C−H Alkynylation of N‑Phenoxyacetamides with Terminal Alkyne[J]. ACS Catalysis,2016,6(0):6999 ...
http://cas-ir.dicp.ac.cn/handle/321008/148312
Non-fluorescent alkynesNon-fluorescent alkynes
Various non-fluorescent alkynes for copper-catalyzed Click Chemistry. Fluorescent dye alkynes are listed under Reactive dyes category.
https://www.lumiprobe.com/catalog/click-chemistry-alkynes
Organic Chemistry/Alkynes - Wikibooks, open books for an open worldOrganic Chemistry/Alkynes - Wikibooks, open books for an open world
As you should know already, carbon is generally found in a tetravalent state - it forms four covalent bonds with other atoms. As you know from the section on alkenes, all four bonds are not necessarily to different atoms, because carbon atoms can double-bond to one another. What this does is create the appearance of only being bound to three other atoms, but in actuality four bonds exist. Alkenes are molecules that consist of carbon and hydrogen atoms where one or more pairs of carbon atoms participate in a double bond, which consists of one sigma (σ) and one pi (π) bond. Alkynes are also molecules consisting of carbon and hydrogen atoms, but instead of forming a double bond with only one sigma (σ) and one pi (π) bond, the alkyne has at least one pair of carbon atoms who have a σ and two π bonds -- a triple bond. The carbon-carbon triple bond, then, is a bond in which the carbon atoms share an s and two p orbitals to form just one σ and two π bonds between them. This results in a linear ...
https://en.m.wikibooks.org/wiki/Organic_Chemistry/Alkynes
Raman imaging of alkyne as a small tag for biological molecules | (2012) | Fujita | Publications | SpieRaman imaging of alkyne as a small tag for biological molecules | (2012) | Fujita | Publications | Spie
Role of small molecules such as drugs or metabolites in cells is commonly studied by fluorescence microscopy in which a fluorescent label is attached to the molecule. However, fluorescent labels are typically large that often interfere with the normal cellular function of the molecule. To avoid the use of bulky fluorescent labels, we introduce a technique that uses a simple small chemical tag called alkyne consisting of two carbons connected by a triple bond. The alkyne-tagged molecule is imaged using Raman microscopy that detects the strong Raman signal from the CC triple bond stretching vibration (~2120 cm-1). Because the alkyne signal is located in the silent region of the cell (1800-2700 cm-1), it does not interfere with any intrinsic cellular Raman signals. Here, we demonstrate this technique by showing Raman images of an alkyne-tagged component of DNA in a living cell using a slit-scanning confocal Raman microscope. This fast imaging technique is based on a line-shaped focus illumination ...
http://spie.org/Publications/Proceedings/Paper/10.1117/12.907984
Alkyne Reactions & Tautomerization: Crash Course Organic Chemistry #18Alkyne Reactions & Tautomerization: Crash Course Organic Chemistry #18
Carbon-carbon double bonds are pretty common in nature, but triple bonds between carbons, called alkynes, are not. When alkynes...
https://bagoscoop.github.io/videos/watch/alkyne-reactions-tautomerization-crash-course-organic-chemistry-18
Dr. Carolyn Bertozzi pioneers bioorthogonal chemistry to study molecules within living systems - IPWatchdog.com | Patents &...Dr. Carolyn Bertozzi pioneers bioorthogonal chemistry to study molecules within living systems - IPWatchdog.com | Patents &...
Bioorthogonal chemistry was pioneered by Dr. Carolyn Bertozzi, a 2017 inductee into the National Inventors Hall of Fame. Her work in Immunology earned her--
http://www.ipwatchdog.com/2017/10/05/evolution-of-tech-dr-carolyn-bertozzi-invents-bioorthogonal-chemistry-to-study-molecules-within-living-systems/id=88882/
Alkenes & Alkynes - Crash Course Chemistry #41 lesson plan | SpiralAlkenes & Alkynes - Crash Course Chemistry #41 lesson plan | Spiral
Alkenes & Alkynes - Crash Course Chemistry #41 - lesson plan ideas from Spiral. Tagged under: Chemistry (Professional Field),crash ,chemistry,molecule,energy,chemical bonds,Leucippus,atomic theory, nucleus,organic chemistry,Organic Chemistry (Field Of Study),alkanes,isomers,structure,alkenes,alkynes,naming rules,cis trans isomerism,hydrogenation,halogenation,polymerization,triglycerides,names fats
https://spiral.ac/sharing/nxqrmcz/alkenes-alkynes-crash-course-chemistry-41
PA (Propargyl Alcohol) - Lapointe Uluslar Arası Ticaret | DanışmanlıkPA (Propargyl Alcohol) - Lapointe Uluslar Arası Ticaret | Danışmanlık
Toxicocinétique et métabolisme Lalcool propargylique (Propargil Alkol, Propargyl Alcohol) est probablement métabolisé en aldéhyde propargylique. Cette oxydation a été démontrée in vitro dans des expériences avec la catalase obtenue à partir de foie de bovin. Des expériences in vitro avec des microsomes hépatiques de rats induits par le phénobarbital ont révélé de faibles niveaux de liaison de lalcool propargylique (Propargil Alkol, Propargyl Alcohol) au cytochrome P450 (BG Chemie 1999). 3 Effets chez lhomme Il ny a pas de données sur les effets chez lhomme dune exposition à lalcool propargylique (Propargil Alkol, Propargyl Alcohol). 262 Propargyl Alcohol (Propargil Alkol, Propargyl Alcohol) Volume 21 Propargyl Alcohol (Propargil Alkol, Propargyl Alcohol) 4 Expérimentation animale et études in vitro 4.1 Toxicité aiguë Lalcool propargylique (Propargil Alkol, Propargyl Alcohol) sest avéré toxique après administration orale, application cutanée et exposition par ...
https://lapointe.com.tr/en/pa-propargyl-alcohol-2
irdye compounds for labelingirdye compounds for labeling
LI-COR now offers a portfolio of Click Chemistry reagents for copper-catalyzed and copper-free methods. These products offer researchers flexibility to choose the correct reagent for a diverse array of applications. LI-COR Click Chemistry reagents include IRDye® 800CW, IRDye 680RD, and IRDye 650 infrared fluorescent dyes labeled with DBCO, azide, or alkyne groups. Click Chemistry utilizes pairs of reagents that exclusively react with each other and are effectively inert to naturally-occurring functional groups such as amines. Unlike affinity interactions such as streptavidin-biotin, Click Chemistry forges covalent bonds between the reacting partners to deliver stable bioconjugates.. Click Chemistry reactions can be categorized into two separate groups, copper-catalyzed or copper-free. Copper-catalyzed Click Chemistry is used for initiating reactions between azides and alkynes. These reactions are also known as Copper-Catalyzed Azide-Alkyne Cycloaddition (CuAAC). Although they initiate and ...
http://www.licor.com/bio/blog/tag/irdye-compounds-for-labeling/
dbco groupsdbco groups
LI-COR now offers a portfolio of Click Chemistry reagents for copper-catalyzed and copper-free methods. These products offer researchers flexibility to choose the correct reagent for a diverse array of applications. LI-COR Click Chemistry reagents include IRDye® 800CW, IRDye 680RD, and IRDye 650 infrared fluorescent dyes labeled with DBCO, azide, or alkyne groups. Click Chemistry utilizes pairs of reagents that exclusively react with each other and are effectively inert to naturally-occurring functional groups such as amines. Unlike affinity interactions such as streptavidin-biotin, Click Chemistry forges covalent bonds between the reacting partners to deliver stable bioconjugates.. Click Chemistry reactions can be categorized into two separate groups, copper-catalyzed or copper-free. Copper-catalyzed Click Chemistry is used for initiating reactions between azides and alkynes. These reactions are also known as Copper-Catalyzed Azide-Alkyne Cycloaddition (CuAAC). Although they initiate and ...
http://www.licor.com/bio/blog/tag/dbco-groups/
Photo-mediated copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) click reactions for forming polymer networks as shape...Photo-mediated copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) click reactions for forming polymer networks as shape...
Photo-mediated copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) click reactions for forming polymer networks as shape memory materials Journal Article ...
https://experts.colorado.edu/display/pubid_93364
talks.cam : Coordination-Assisted Bioorthogonal Chemistry: Bringing Orthogonality in the Tetrazine Ligation with (strained)...talks.cam : Coordination-Assisted Bioorthogonal Chemistry: Bringing Orthogonality in the Tetrazine Ligation with (strained)...
If you have a question about this talk, please contact .. The development of bioorthogonal reactions made it possible to visualize and study biomolecules in their native cellular context and contributed to advanced targeted drug delivery strategies. In our research group we are interested in developing novel bioorthogonal chemistry and apply this in the targeting of specific cell types. We recently added non-strained, highly soluble and stable vinylboronic acids (VBA) as reactants to the bioorthogonal toolbox which react with tetrazines in an inverse-electron demand Diels-Alder reaction. We have observed exceptional high reaction rates between non-strained vinylboronic acids (VBAs) and dipyridyl tetrazines relative to that of tetrazines lacking such dative coordinating ligand. As VBAs are mild Lewis acids, we hypothesize that coordination of the pyridyl to the boronic acid promotes the tetrazine ligation. In the current presentation, we explore the scope and molecular origins of the observed VBA ...
http://talks.cam.ac.uk/talk/index/122671
Nomination Summary for Propargyl alcohol (N96043)Nomination Summary for Propargyl alcohol (N96043)
Nominated Substances: Propargyl alcohol. Nomination Date: 09/20/1996 Nominator: NCI Rationale: Propargyl alcohol is nominated for subchronic studies based on potential for human exposure and a suspicion of carcinogenicity. Propargyl alcohol is a high production volume chemical which is used mainly as a chemical intermediate for a variety of products. It has been identified in air, soil and solid waste. The suspicion of carcinogenicity is based on its metabolism to the aldehyde and positive results in genotoxicity studies. The hepatotoxicity observed in previous studies is similar to that produced by carbon tetrachloride. Chronic toxicity data is lacking. NTP Principles: 1, 2, 7. ...
https://ntp.niehs.nih.gov/getinvolved/nominate/summary/nm-n96043.html
Nickel-Catalyzed Coupling of Carbonyl Compounds and Alkynes or 1 3-Dienes An Efficient Method for the Preparation of...Nickel-Catalyzed Coupling of Carbonyl Compounds and Alkynes or 1 3-Dienes An Efficient Method for the Preparation of...
Highlights Ni-Catalyzed Coupling Reactions Nickel-Catalyzed Coupling of Carbonyl Compounds and Alkynes or 1,3-Dienes: An Efficient Method for the Preparation of Allylic, Homoallylic, and Bishomoallylic Alcohols Shin-ichi Ikeda* Keywords: alcohols · C C coupling · catalysis · multicomponent reactions · nickel The alkenylation, allylation, and homoallylation of carbonyl compounds, which gives allylic, homoallylic, and bishomoallylic alcohols, respectively, are important processes in the formation of carbon-carbon bonds. However, in these approaches, the preparation of the corresponding alkenylating, allylating, and homoallylating reagents, which often requires troublesome procedures, is unavoidable.[1-5] Recently, new nickelcatalyzed coupling reactions of a carbonyl compound (e.g., aldehyde or ketone) and an unsaturated substrate (e.g., alkyne or 1,3-diene) with an organometallic or metal hydride have been reported, and these offer more efficient methods to give the desired alcohols without ...
https://www.docme.ru/doc/1949227/nickel-catalyzed-coupling-of-carbonyl-compounds-and-alkyn..
Visible-light-mediated dehydrogenative cross-coupling between terminal alkynes and aldehydes by employing a supramolecular...Visible-light-mediated dehydrogenative cross-coupling between terminal alkynes and aldehydes by employing a supramolecular...
Kataria, Meenal ; Deol, Harnimarta ; Singh, Gurpreet ; Kumar, Manoj ; Bhalla, Vandana (2018) Visible-light-mediated dehydrogenative cross-coupling between terminal alkynes and aldehydes by employing a supramolecular polymeric ensemble of PBI derivative New Journal of Chemistry, 42 (2). pp. 822-826. ISSN 1144-0546 Full text not available from this repository.. Official URL: http://pubs.rsc.org/en/content/articlelanding/2018.... Related URL: http://dx.doi.org/10.1039/C7NJ03557H ...
http://repository.ias.ac.in/114443/
Isolated, well-defined organovanadium(III) on silica: Single-site catalyst for hydrogenation of alkenes and alkynes<...Isolated, well-defined organovanadium(III) on silica: Single-site catalyst for hydrogenation of alkenes and alkynes<...
TY - JOUR. T1 - Isolated, well-defined organovanadium(III) on silica. T2 - Single-site catalyst for hydrogenation of alkenes and alkynes. AU - Sohn, H.. AU - Camacho-Bunquin, J.. AU - Langeslay, R. R.. AU - Ignacio-De Leon, P. A.. AU - Niklas, J.. AU - Poluektov, O. G.. AU - Liu, C.. AU - Connell, J. G.. AU - Yang, D.. AU - Kropf, J.. AU - Kim, H.. AU - Stair, P. C.. AU - Ferrandon, M.. AU - Delferro, M.. PY - 2017/1/1. Y1 - 2017/1/1. N2 - A well-defined, isolated, single-site organovanadium(iii) catalyst on SiO2 [(SiO2)V(Mes)(THF)] was synthesized via surface organometallic chemistry, and fully characterized using a combination of analytical and spectroscopic techniques (EA, ICP, 1H NMR, TGA-MS, EPR, XPS, DR-UV/Vis, UV-Raman, DRIFTS, XAS). The catalyst exhibits unprecedented reactivity in liquid-and gas-phase alkene/alkyne hydrogenation. Kinetic poisoning experiments revealed that 100% of the V sites are active for hydrogenation.. AB - A well-defined, isolated, single-site organovanadium(iii) ...
https://sofi-northwestern.pure.elsevier.com/en/publications/isolated-well-defined-organovanadiumiii-on-silica-single-site-cat
Alkyne nomenclature | Alkenes and Alkynes | Organic chemistry | Khan AcademyAlkyne nomenclature | Alkenes and Alkynes | Organic chemistry | Khan Academy
Rules for naming alkynes (molecules with a carbon-carbon triple bond). Created by Jay. Watch the next lesson: https://www.khanacademy.org/science/organic-chemistry/alkenes-alkynes/naming-preparation-alkynes/v/alkyne-acidity-and-alkylation?utm_source=YT&utm;_medium=Desc&utm;_campaign=organicchemistry Missed the previous lesson? https://www.khanacademy.org/science/organic-chemistry/alkenes-alkynes/alkene-reactions-tutorial/v/ozonolysis-1?utm_source=YT&utm;_medium=Desc&utm;_campaign=organicchemistry Organic Chemistry on Khan Academy: Carbon can form covalent bonds with itself and other elements to create a mind-boggling array of structures. In organic chemistry, we will learn about the reactions chemists use to synthesize crazy carbon based structures, as well as the analytical methods to characterize them. We will also think about how those reactions are occurring on a molecular level with reaction mechanisms. Simply put, organic chemistry is like building with molecular Legos. Lets make some
https://curiosity.com/videos/alkyne-nomenclature-or-alkenes-and-alkynes-or-organic-chemistry-or-khan-academy-khan-academy
POLYCYCLIC AROMATIC RING SYNTHESIS USING PALLADIUM CATALYZED C-H ACTIVATION AND ENAMINE-CATALYZED [3+2] CYCLOADDITION REACTIONS...POLYCYCLIC AROMATIC RING SYNTHESIS USING PALLADIUM CATALYZED C-H ACTIVATION AND ENAMINE-CATALYZED [3+2] CYCLOADDITION REACTIONS...
Huge advances have been made in the field of palladium catalyzed C-H activation in the past decade. The application of palladium catalyzed C-H activation to form complex, multifunctional substrates, especially directly C-H alkynylation are positively exploring. We have recently successfully elucidated a series of palladium catalyzed C-H alkynylation from commercial available material. These transformations included synthesis of highly substituted cyclopentadiene fused chromones from cascade reactions of coumarins with alkynes and C¿H/N¿H dual activation to synthesize benzazepines from isatin and alkynes; Recent years have witnessed an explosive growth in the field of iminium and enamine catalysis. Primary and secondary amines as catalysis in the cycloaddition transformation of biological and pharmaceutical compounds via the iminmium activation model have been greatly explored. We have successfully explored a series of enamine catalyzed [3+2] cycloaddition. These pioneering works consisted by ...
http://scholarbank.nus.edu.sg/handle/10635/38751
Sonogashira coupling - WikipediaSonogashira coupling - Wikipedia
The Sonogashira reaction is a cross-coupling reaction used in organic synthesis to form carbon-carbon bonds. It employs a palladium catalyst to form a carbon-carbon bond between a terminal alkyne and an aryl or vinyl halide. R − ≡ − H + R ′ − X → base, rt Pd cat., Cu cat. R − ≡ − R ′ {\displaystyle {\begin{matrix}{}\\{\ce {R-\!{\equiv }\!-H}}+{\color {Red}{\ce {R}}}\!-\!{\ce {X->[{\text{Pd cat., Cu cat.}}][{\text{base, rt}}]R-\!{\equiv }\!}}{\color {Red}{\ce {-R}}}\end{matrix}}} R: Aryl or Vinyl X: I, Br, Cl or OTf The Sonogashira cross-coupling reaction has been employed in a wide variety of areas, due to its usefulness in the formation of carbon-carbon bonds. The reaction can be carried out under mild conditions, such as at room temperature, in aqueous media, and with a mild base, which has allowed for the use of the Sonogashira cross-coupling reaction in the synthesis of complex molecules. Its applications include pharmaceuticals, natural products, organic materials, ...
https://en.wikipedia.org/wiki/Sonogashira_coupling
Sonogashira couplingSonogashira coupling
The Sonogashira reaction is a cross-coupling reaction used in organic synthesis to form carbon-carbon bonds . It employs a palladium catalyst to form a carbon-carbon bond between a terminal alkyne and an aryl or vinyl halide . The Sonogashira cross-coupling reaction has been employed in a wide variety of areas, due to its usefulness in the formation of carbon-carbon bonds. The reaction can be carried out under mild conditions, such as at room temperature, in aqueous media, and with a mild base, which has allowed for the use of the Sonogashira cross-coupling reaction in the synthesis of complex molecules. Its applications include pharmaceuticals, natural products, organic materials, and nanomaterials. Specific examples include its use in the synthesis of tazarotene , which is a treatment for psoriasis and acne , and in the preparation of SIB-1508Y, also known as Altinicline , which is a potential treatment for Parkinson's disease , Alzheimer's disease , Tourette syndrome , schizophrenia ,
https://www.revolvy.com/topic/Sonogashira+coupling
中国科学院上海有机化学研究所机构知识库(SIOC OpenIR): Ruthenium-catalyzed 1,3-dipolar cycloaddition of trifluoromethylated propargylic alcohols...中国科学院上海有机化学研究所机构知识库(SIOC OpenIR): Ruthenium-catalyzed 1,3-dipolar cycloaddition of trifluoromethylated propargylic alcohols...
The 1,3-dipolar cycloaddition of trifluoromethylated propargylic alcohols 1 with azides in the presence of catalytic [Cp*RuCl2], afforded exclusively 4-trifluoroniethyl-1,4,5-trisubstituted-1,2,3-triazoles 2 in high yields. (c) 2008 Elsevier Ltd. All rights reserved ...
http://ir.sioc.ac.cn/handle/331003/17641
Ligand-Promoted, Copper Nanoparticles Catalyzed Oxidation of Propargylic Alcohols with TBHP or Air as OxidantLigand-Promoted, Copper Nanoparticles Catalyzed Oxidation of Propargylic Alcohols with TBHP or Air as Oxidant
see article for more reactions. Abstract. A highly efficient oxidation of propargylic alcohols to ynones is catalyzed by copper nanoparticles (Cu Nps) with TBHP or air as oxidants. With bipyridine as the ligand, the reaction was accelerated significantly and led in good to excellent yields to a variety of propargylic alcohols.. ...
http://www.organic-chemistry.org/abstracts/lit3/413.shtm
中国科学院大连化学物理研究所机构知识库(DICP OpenIR): Iridium- and Rhodium-Catalyzed C-H Activation and Formyl Alkynylation of Benzaldehydes under...中国科学院大连化学物理研究所机构知识库(DICP OpenIR): Iridium- and Rhodium-Catalyzed C-H Activation and Formyl Alkynylation of Benzaldehydes under...
Mild and efficient synthesis of ynones via Ir(III)- and Rh(III)-catalyzed, chelation-assisted formyl C-H alkynylation of benzaldehydes has been achieved using hypervalent iodine-alkyne reagents. Rhodium and iridium catalysis exhibited complementary substrate scope ...
http://cas-ir.dicp.ac.cn/handle/321008/146044
Synthesis of Imidazole-Derived Ionic Liquids from Monoterpenes by Means of the Sonogashira Reaction | Marcelo SpezialiSynthesis of Imidazole-Derived Ionic Liquids from Monoterpenes by Means of the Sonogashira Reaction | Marcelo Speziali
Speziali MG, Monteiro AL. Synthesis of Imidazole-Derived Ionic Liquids from Monoterpenes by Means of the Sonogashira Reaction. Synthesis-StuttgartSynthesis-StuttgartSynthesis-Stuttgart. 2012;44:3505-3511.
http://professor.ufop.br/marcelo/publications/synthesis-imidazole-derived-ionic-liquids-monoterpenes-means-sonogashira
New digold catalysts yield enantiopure cyclobutenesNew digold catalysts yield enantiopure cyclobutenes
Prof. Echavarrens group presents the first general enantioselective synthesis of cyclobutenes by intermolecular [2+2] cycloadditions. Digold complexes catalyse the reaction between terminal alkynes and alkenes leading to chiral cyclobutenes, useful in organic chemistry because they can be hydrogenated into functionalised cyclobutanes, which are motifs present in a variety of natural products and pharmaceuticals.. Previous attempts to achieve this transformation required activated alkynes or strained alkenes. The new strategy developed at ICIQ works for an enormous variety of terminal alkynes and a myriad of both disubstituted and trisubstituted alkenes. In total, this gold-catalysed reaction was used to synthesize a scope of over 40 different products, all with good yields and excellent enantiomeric ratios.. Due to the linear geometry of gold(I) complexes, chiral ligands are usually far away from the reaction centre. Hence, finding the gold catalysts that yield enantioselective transformations ...
http://www.iciq.org/new-digold-catalysts-yield-enantiopure-cyclobutenes/
Publications 2007Publications 2007
M. Konkol, H. Schmidt, D. Steinborn, J. Mol. Catal. A: Chemical 2007, 261, 301 - 305. „Iridium-catalyzed addition of methanol to internal alkynes. ___________________________________________________________. M. Konkol, H. Schmidt, D. Steinborn, J. Mol. Catal. A: Chemical 2007, 269, 119 - 124. „Iridium-catalyzed addition of methanol to terminal alkynes ___________________________________________________________. M. Vavra, I. Potočň k, M. Dušek, K. Fejfarov , C. Wagner, D. Steinborn, Achievements in Coordination, Bioinorganic and Applied Inorganic Chemistry (Eds. M. Melnik, J. ima, M. Tatarko), STU Press, Bratislava, 2007, 333 - 344 ...
http://www.chemie.uni-halle.de/bereiche_der_chemie/anorganische_chemie/ak_steinborn/1788187_1788214/1788214_1788993/?lang=en
A minireview of hydroamination catalysis: alkene and alkyne substrate selective, metal complex design | BMC Chemistry | Full...A minireview of hydroamination catalysis: alkene and alkyne substrate selective, metal complex design | BMC Chemistry | Full...
Organic compounds that contain nitrogen are very important intermediates in pharmaceutical and chemical industry. Hydroamination is the reaction that can form C-N bond with high atom economy. The research progress in metals catalyzed hydroamination of alkenes and alkynes from the perspective of reaction mechanism is categorized and summarized.
https://bmcchem.biomedcentral.com/articles/10.1186/s13065-019-0606-7/schemes/19
Synthesis of Natural Product-like Polyheterocycles via One-Pot Cascade Oximation, C-H Activation, and Alkyne Annulation - ...Synthesis of Natural Product-like Polyheterocycles via One-Pot Cascade Oximation, C-H Activation, and Alkyne Annulation - ...
Mentioning: 12 - An efficient protocol for the direct transformation of chroman-4-ones to tricyclic fused pyridines with the skeleton of cassiarins, a family of alkaloids with antimalarial activity, was developed. Also, a general strategy for modular construction of polyheterocycles with diverse natural product-like skeletons was developed by using ketone-alkyne bifunctional substrates. These reactions involved a one-pot cascade oximation of ketones, rhodium-catalyzed C-H activation, and intermolecular/intramolecular alkyne annulations under mild conditions with high atom, step, and redox economy.
https://scite.ai/reports/synthesis-of-natural-product-like-polyheterocycles-Ozp114
Alkyl Bromides as Mild Hydride Sources in Ni-Catalyzed Hydroamidation of Alkynes with IsocyanatesAlkyl Bromides as Mild Hydride Sources in Ni-Catalyzed Hydroamidation of Alkynes with Isocyanates
A catalytic hydroamidation of alkynes with isocyanates using alkyl bromides as hydride sources has been developed. The method turns parasitic β-hydride elimination into a strategic advantage, rapidly affording acrylamides with excellent chemo- and regioselectivity.. ...
http://www.iciq.org/research/publication/alkyl-bromides-as-mild-hydride-sources-in-ni-catalyzed-hydroamidation-of-alkynes-with-isocyanates/
Amidate complexes of titanium and zirconium: a new class of tunable precatalysts for the hydroamination of alkynes | UBC...Amidate complexes of titanium and zirconium: a new class of tunable precatalysts for the hydroamination of alkynes | UBC...
A series of bis(amidate)group 4-bis(amido) complexes have been prepared, characterized and have been shown to be highly tunable precatalysts for both the intra- and intermolecular hydroamination of alkynes.. ...
https://chem.ubc.ca/amidate-complexes-titanium-and-zirconium-new-class-tunable-precatalysts-hydroamination-alkynes
Naphthoquinones from alkynes and chromium-carbene complexes-control of regioselectivity through intramolecular reaction<...Naphthoquinones from alkynes and chromium-carbene complexes-control of regioselectivity through intramolecular reaction<...
TY - JOUR. T1 - Naphthoquinones from alkynes and chromium-carbene complexes-control of regioselectivity through intramolecular reaction. AU - Semmelhack, Martin F.. AU - Bozell, Joseph J.. PY - 1982/1/1. Y1 - 1982/1/1. N2 - A series of carbene-chromium complexes bearing a phenyl substituent and an alkoxy-alkyne substituent have been prepared by acetoxy replacement. Intramolecular cycloaddition with carbon monoxide insertion occurs to provide naphthohydroquinones in good yield.. AB - A series of carbene-chromium complexes bearing a phenyl substituent and an alkoxy-alkyne substituent have been prepared by acetoxy replacement. Intramolecular cycloaddition with carbon monoxide insertion occurs to provide naphthohydroquinones in good yield.. UR - http://www.scopus.com/inward/record.url?scp=0000695788&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0000695788&partnerID=8YFLogxK. U2 - 10.1016/S0040-4039(00)87497-3. DO - 10.1016/S0040-4039(00)87497-3. M3 - Article. AN - ...
https://collaborate.princeton.edu/en/publications/naphthoquinones-from-alkynes-and-chromium-carbene-complexes-contr
Post Modification of Acetylene Functional Poly(oxindole biphenylylene) by Photoinduced CuAAC - KAUST RepositoryPost Modification of Acetylene Functional Poly(oxindole biphenylylene) by Photoinduced CuAAC - KAUST Repository
A novel strategy to obtain side chain modified poly(oxindole biphenylylene) (POXI) by photoinduced copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) click reaction is described. In the first step, an alkyne-functionalized poly(oxindolebiphenylylene) (POXI-alkyne) is synthesized by superacid-catalyzed condensation of isatin with aromatic hydrocarbons. Subsequently, poly(ethylene glycol) methyl ether (Me-PEG), 1-pyrenemethanol (Py-OH) and 1,3-dibromopropane (DBP) are functionalized by azide groups via simple nucleophilic substitution reaction. Visible-light-induced CuAAC reaction between POXI-alkyne and the corresponding azide functionalized click components employing dibenzoyldiethylgermane (DBDEG) as photoactivator resulted in the formation of POXI-PEG, POXI-Py and insoluble network, respectively. Successful modification of POXI was confirmed by the spectral, (1H NMR, FT-IR, Fluorescence), chromatographic (GPC) and thermal (DSC) investigations ...
http://repository.kaust.edu.sa/kaust/handle/10754/627125
On-Surface Azide-Alkyne Cycloaddition on Cu(111): Does It Click in Ultrahigh Vacuum? - Danish National Research Database-Den...On-Surface Azide-Alkyne Cycloaddition on Cu(111): Does It Click in Ultrahigh Vacuum? - Danish National Research Database-Den...
Interdisciplinary Nanoscience Center - INANO-Fysik, iNANO-huset, Interdisciplinary Nanoscience Center, Science and Technology, Aarhus ...
http://www.forskningsdatabasen.dk/catalog/236149213
Precise grafting of macrocyclics and dendrons to a linear polymer chain<...Precise grafting of macrocyclics and dendrons to a linear polymer chain<...
TY - JOUR. T1 - Precise grafting of macrocyclics and dendrons to a linear polymer chain. AU - Amir, Faheem. AU - Hossain, Md D.. AU - Jia, Zhongfan. AU - Monteiro, Michael J.. PY - 2016/8/31. Y1 - 2016/8/31. N2 - Sequential growth of multifunctional telechelic polymer chains was used here to produce three, four or seven HO-functionalities equally spaced along the polymer backbone. The telechelic building block consisted of a halide group on one end and both a hydroxyl and alkyne group on the other end. The key was to maintain the halide end-group on the telechelic polymer chain during the CuAAC coupling reaction after each sequential growth. This was accomplished by using the combination of the PMDETA ligand and toluene as a solvent to produce significantly faster rates of CuAAC coupling reaction over halide abstraction. The HO-functionalities were then converted to azide groups allowing further CuAAC reactions with either alkyne polymeric dendrons or cyclics to produce equally spaced grafts ...
https://researchnow.flinders.edu.au/en/publications/precise-grafting-of-macrocyclics-and-dendrons-to-a-linear-polymer
Notes and Important Points on Alkanes, Alkenes and Alkynes - Chemistry - KCET EngineeringNotes and Important Points on Alkanes, Alkenes and Alkynes - Chemistry - KCET Engineering
Free Notes on Alkanes, Alkenes and Alkynes - KCET Engineering. Read all the Important points and Chapterwise Notes on KCET Engineering
https://www.simplylearnt.com/notes/Alkanes--Alkenes-and-Alkynes-7
Effect of heteroatom on tandem cycloaddition-Cycloreversion of 2-pyrone and 1,4-oxazinone with hetero alkynes: A DFT explorationEffect of heteroatom on tandem cycloaddition-Cycloreversion of 2-pyrone and 1,4-oxazinone with hetero alkynes: A DFT exploration
Reactions of 2-pyrone (2P) and 1,4-oxazinone (OXZ) with hetero alkynes viz., phosphines (HA1) and silanes (HA2) have been scanned at B3LYP/6-31G(d) level.
http://www.chemistryjournal.in/archives/2018/vol2/issue5/2-6-15
H CC 9.5 Acidity of Acetylene and Terminal Alkynes. - ppt downloadH CC 9.5 Acidity of Acetylene and Terminal Alkynes. - ppt download
Acetylene is a weak acid, but not nearly as weak as alkanes or alkenes. CompoundpK a HF3.2 H 2 O16 NH CH 4 60 H2CH2CH2CH2C CH 2 HCCH 26 Acetylene
http://slideplayer.com/slide/4385380/
dPEG® Compounds from Quanta Biodesign - PEGylation | Sigma-AldrichdPEG® Compounds from Quanta Biodesign - PEGylation | Sigma-Aldrich
These are dPEG® compounds from Quanta Biodesign that contain discrete length PEGs. This can improve reproducibility in experiments when compared to using PEGs of variable length. PEGS have high aqueous solubility and a substances aqueous solubility can be improved by attaching a PEG. Some of these compounds contain a single reactive end for attachment to proteins such as through amines or sulfhydryls. This list includes branched PEGs which are more compact than long linear PEGs. There are also compounds with two reactive ends for crosslinking. Some of the compounds have azide groups which can be attached to alkynes using copper click chemistry or to strained alkynes through copper-free click chemistry. Some of the compounds have a biotin on one end for capture by avidins. Overall the many options offered by these dPEG® products can enable a variety of biconjugation applications.
https://www.sigmaaldrich.com/chemistry/chemistry-products.html?TablePage=122064803
New Synthetic routes towards constrained cyclic peptides inspired by vancomycinNew Synthetic routes towards constrained cyclic peptides inspired by vancomycin
Vancomycin is the last resort antibiotic against MRSA. Vancomycin causes the bacteria to die by physically blocking a recognition site within the cell wall. This recognition site binds to the inner cavity of vancomycin, which consists of a rigid bicyclic structure. The objective of my research was to mimic this ... read more bicyclic structure using synthetic alkene and alkyne bridges, and to see if a similar cavity was obtained. The alkene bridges were introduced using a (tandem) ring-closing metathesis reaction and the alkyne bridges were introduced by a Sonogashira reaction. show less ...
https://dspace.library.uu.nl/handle/1874/19143
Ionic Liquid Iodinating Reagent for Mild and Efficient Iodination of Aromatic and Heteroaromatic Amines and Terminal AlkynesIonic Liquid Iodinating Reagent for Mild and Efficient Iodination of Aromatic and Heteroaromatic Amines and Terminal Alkynes
A free platform for explaining your research in plain language, and managing how you communicate around it - so you can understand how best to increase its impact.
https://www.growkudos.com/publications/10.1080%25252F00397911.2012.749991/reader
Molecules | Free Full-Text | Peptide Conjugation via CuAAC Click ChemistryMolecules | Free Full-Text | Peptide Conjugation via CuAAC Click Chemistry
The copper (I)-catalyzed alkyne azide 1,3-dipolar cycloaddition (CuAAC) or click reaction, is a highly versatile reaction that can be performed under a variety of reaction conditions including various solvents, a wide pH and temperature range, and using different copper sources, with or without additional ligands or reducing agents. This reaction is highly selective and can be performed in the presence of other functional moieties. The flexibility and selectivity has resulted in growing interest in the application of CuAAC in various fields. In this review, we briefly describe the importance of the structural folding of peptides and proteins and how the 1,4-disubstituted triazole product of the CuAAC reaction is a suitable isoster for an amide bond. However the major focus of the review is the application of this reaction to produce peptide conjugates for tagging and targeting purpose, linkers for multifunctional biomacromolecules, and reporter ions for peptide and protein analysis.
http://mdpi.com/1420-3049/18/11/13148
Multiarm Star Block Copolymers via Diels-Alder Click Reaction | AVESİSMultiarm Star Block Copolymers via Diels-Alder Click Reaction | AVESİS
Two types of multiarm star block copolymers: (polystyrene)(m)-poly(divinylbenzene)-poly(methyl methacrylate)(n), (PS)(m),-polyDVB-(PMMA)(n) and (polystyrene)(m)-poly(divinylbenzene)-poly(tert-butyl acrylate)(k), (PS)(m)-polyDVB-(PtBA)(k) were successfully prepared via a combination of cross-linking and Diels-Alder click reactions based on arm-first methodology. For this purpose, multiarm star polymer with anthracene functionality as reactive periphery groups was prepared by a cross-linking reaction of divinyl benzene using a-anthracene end functionalized polystyrene (PSAnth) as a macroinitiator. Thus, obtained multiarm star polymer was then reacted with furan protected maleimide-end functionalized polymers: PMMA-MI or PtBA-MI at reflux temperature of toluene for 48 h resulting in the corresponding multiarm, star block copolymers via Diels-Alder click reaction. The multiarm star and multiarm star block copolymers were characterized by using H-1 NMR, SEC, Viscotek triple detection SEC (TD-SEC) ...
https://avesis.bezmialem.edu.tr/yayin/ecca41c6-78f8-49a3-b502-a607d85ff0d7/multiarm-star-block-copolymers-via-diels-alder-click-reaction
Download Click reactions in organic synthesis by Srinivasan Chandrasekaran PDF - Choosing Exellence E-booksDownload Click reactions in organic synthesis by Srinivasan Chandrasekaran PDF - Choosing Exellence E-books
0)non-5-ene (DBN). 14). 14 Tertiary-amine-catalyzed thiol-isocyanate click reaction. 3 Thiol-Michael Addition Click Reactions Hydrothiolation of C==C double bond can be performed in the presence of mild bases or using nucleophilic catalysis. Unlike thiol-ene radical reaction (which can proceed with almost all olefins), thiol Michael addition reactions require activated carbon-carbon double bonds, which are in conjugation with an EWG. In the presence of trialkylamine bases such as NEt3 , the reaction proceeds smoothly to give the addition products in very high yields. This family includes 15 isoenzymes (I-XIV, V further subclassified as VA and VB) endowed with different molecular features, cellular localization, distribution in organs and tissues, and kinetic properties. It has been demonstrated that the dysfunction of these enzymes is related to different pathologies such as cancer (CAs VII, IX, XII), neurodegeneration (CA VIII), obesity (CAs VA and VB), and sterility (CA XIII) [36]. 3). 76) ...
http://choosingexcellence.org/library/click-reactions-in-organic-synthesis
Rearrangement of indene skeletons under mild conditions<...Rearrangement of indene skeletons under mild conditions<...
TY - JOUR. T1 - Rearrangement of indene skeletons under mild conditions. AU - Kuninobu, Yoichiro. AU - Ueda, Hirokazu. AU - Kawata, Atsushi. AU - Takai, Kazuhiko. PY - 2007/8/31. Y1 - 2007/8/31. N2 - (Chemical Equation Presented) Isomerization between two isomers of 1,2-disubstituted 3-aminoindenes occurs via the rearrangement of indene frameworks. In contrast to previous rearrangements of indene derivatives, which occur under high-temperature conditions or the irradiation of light, this rearrangement proceeds at room temperature without UV light irradiation. An amino group at the 3-position plays an important role to accelerate the rearrangement under mild conditions.. AB - (Chemical Equation Presented) Isomerization between two isomers of 1,2-disubstituted 3-aminoindenes occurs via the rearrangement of indene frameworks. In contrast to previous rearrangements of indene derivatives, which occur under high-temperature conditions or the irradiation of light, this rearrangement proceeds at room ...
https://okayama.pure.elsevier.com/en/publications/rearrangement-of-indene-skeletons-under-mild-conditions
IJMS | Free Full-Text | A Versatile Chemo-Enzymatic Conjugation Approach Yields Homogeneous and Highly Potent Antibody-Drug...IJMS | Free Full-Text | A Versatile Chemo-Enzymatic Conjugation Approach Yields Homogeneous and Highly Potent Antibody-Drug...
The therapeutic efficacy of antibodies can be successfully improved through targeted delivery of potent cytotoxic drugs in the form of antibody-drug conjugates. However, conventional conjugation strategies lead to heterogeneous conjugates with undefined stoichiometry and sites, even with considerable batch-to-batch variability. In this study, we have developed a chemo-enzymatic strategy by equipping the C-terminus of anti-CD20 ofatumumab with a click handle using Sortase A, followed by ligation of the payload based on a strain-promoted azide-alkyne cycloaddition to produce homogeneous conjugates. The resulting antibody-drug conjugates fully retained their antigen binding capability and proved to be internalized and trafficked to the lysosome, which released the payload with a favorable efficacy in vitro and in vivo. Thus, this reported method is a versatile tool with maximum flexibility for development of antibody-drug conjugates and protein modification.
http://www.mdpi.com/1422-0067/18/11/2284
N-Myristoyl Transferase (NMT)-Catalyzed Labeling of Bacterial Proteins for Imaging in Fixed and Live Cells - CaltechAUTHORSN-Myristoyl Transferase (NMT)-Catalyzed Labeling of Bacterial Proteins for Imaging in Fixed and Live Cells - CaltechAUTHORS
Methods for selective protein imaging are critical for elucidating how cells orchestrate fundamental biological processes. We recently developed a chemoenzymatic method to modify bacterial proteins in situ for fluorescence imaging using N-myristoyl transferase (NMT). Target proteins outfitted with an N-terminal NMT recognition sequence are covalently modified with an azido fatty acid. Subsequent strain-promoted azide-alkyne cycloaddition allows for conjugation to cell-permeant fluorophores and imaging by fluorescence microscopy. Here we describe sample preparation and labeling protocols for imaging bacterial proteins in fixed and live cells. ...
https://authors.library.caltech.edu/96228/
SYNTHESIZING IDEAS: Click Chemistry for Pyrrole SynthesisSYNTHESIZING IDEAS: Click Chemistry for Pyrrole Synthesis
Prof. Aiwen Lei and coworkers, Wuhan University, Hubei, have developed a silver catalyst click reaction for the synthesis of pyrrole, by cycloaddition. This system benefits from readily-available starting materials, low catalyst loading (0.1 eq), short reaction times (2 h) and excellent chemo-selectivity. And, works for both internal and alkyl substituted terminal alkynes in the presence of many functional groups. The extremely mild conditions used, makes this reaction synthetically attractive ...
http://syntheticorganic.blogspot.com/2013/05/click-chemistry-for-pyrrole-synthesis.html
RADIOLABELLING METHODS - Patent applicationRADIOLABELLING METHODS - Patent application
0018] Compounds of formula (I) and (III) wherein the vector is a peptide or protein may be prepared by standard methods of peptide synthesis, for example, solid-phase peptide synthesis, for example, as described in Atherton, E. and Sheppard, R. C.; Solid Phase Synthesis; IRL Press: Oxford, 1989. Incorporation of the alkyne or azide group in a compound of formula (I) or (III) may be achieved by reaction of the N or C-terminus of the peptide or with some other functional group contained within the peptide sequence, modification of which does not affect the binding characteristics of the vector. The alkyne or azide groups are preferably introduced to a compound of formula (I) or (III) by formation of a stable amide bond, for example formed by reaction of a peptide amine function with an activated acid or alternatively reaction of a peptide acid function with an amine function and introduced either during or following the peptide synthesis. Methods for incorporation of the alkyne or azide group ...
http://www.patentsencyclopedia.com/app/20110236311
Mass spectral interpretationMass spectral interpretation
Alkynes[edit]. Similar to alkenes, alkynes often show strong molecular ion peak. Propargylic cleavage is a most significant ...
https://en.wikipedia.org/wiki/Mass_spectrum_analysis
Protecting groupProtecting group
Terminal alkyne protecting groups[edit]. *Propargyl alcohols in the Favorskii reaction,. *Silyl groups, especially in ...
https://en.wikipedia.org/wiki/Protecting_group
EsterEster
Addition of carboxylic acids to alkenes and alkynes[edit]. In the presence of palladium-based catalysts, ethylene, acetic acid ... Carboxylic acids also add across alkynes to give the same products. Silicotungstic acid is used to manufacture ethyl acetate by ...
https://en.wikipedia.org/wiki/Esters
Marcey WatersMarcey Waters
"Mechanistic Studies on the Reaction of Fischer Carbene Complex with Alkynes: Does the Alkyne Insertion Intermediate Form ... and alkynes. Walters graduated from Chicago in 1997 with a PhD in chemistry. She was an NIH postdoctoral fellow in Prof. Ronald ...
https://en.wikipedia.org/wiki/Marcey_Waters
Unsaturated hydrocarbonUnsaturated hydrocarbon
"Hydration of Alkynes". Chem LibreTexts. May 2, 2019. Retrieved May 6, 2019. "Reactions of Alkynes - Addition of HX and X2". ... Alkynes, under metal catalysts, for example cobalt, can also go under cycloaddition reaction called alkyne trimerization. Three ... The DCD model can also describe the alkyne ligand structure. Metal complex can also be intermediate of trimerization of alkynes ... The hydrohalogenation of alkyne is much slower than the alkene. The reaction equation of HBr addition to ethene is: H2C=CH2 + ...
https://en.wikipedia.org/wiki/Unsaturated_hydrocarbon
Thiol-yne reactionThiol-yne reaction
The thiol-yne reaction (also known as alkyne hydrothiolation) is an organic reaction between a thiol and an alkyne. The ... Diphenyl disulfide reacts with alkynes to a 1,2-bis(phenylthio)ethylene. Reported alkynes are ynamides. A photoredox thiol-yne ... Yadav, J. S.; Reddy, B. V. Subba; Raju, A.; Ravindar, K.; Baishya, Gakul (2007). "Hydrothiolation of Unactivated Alkynes ... Weiss, Charles J.; Wobser, Stephen D.; Marks, Tobin J. (2009). "Organoactinide-Mediated Hydrothiolation of Terminal Alkynes ...
https://en.wikipedia.org/wiki/Thiol-yne_reaction
EthynylEthynyl
Also sometimes designed as ethinyl in compounds (ethinylestradiol, ethisterone (ethinyltestosterone)). See main page alkynes. ...
https://en.wikipedia.org/wiki/Ethynyl
Favorskii reactionFavorskii reaction
This reaction is used to protect alkynes: the alkyne is either converted with acetone to a 2-hydroxyprop-2-yl-alkyne or a ... A metal acetylide is formed in situ when an alkyne is treated with a strong bases such as a hydroxide or an alkoxide: HC≡CH + ... The Favorskii reaction is an organic chemistry reaction between an alkyne and a carbonyl group, under a basic condition. The ... 3.0.CO;2-R. Wuts, Peter G. M.; Greene, Theodora W. (2007). "Chapter 8. Protection for the Alkynes". Greene's Protective Groups ...
https://en.wikipedia.org/wiki/Favorskii_reaction
KetoneKetone
By hydration of alkynes. Such processes occur via enols and require the presence of an acid and HgSO4. Subsequent enol-keto ... This equilibrium allows ketones to be prepared via the hydration of alkynes. C-H bonds adjacent to the carbonyl in ketones are ... Ketones containing alkene and alkyne units are often called unsaturated ketones. The most widely used member of this class of ... This reaction always produces a ketone, even with a terminal alkyne, the only exception being the hydration of acetylene, which ...
https://en.wikipedia.org/wiki/Ketone
Glossary of engineeringGlossary of engineering
Alkyne Is an unsaturated hydrocarbon containing at least one carbon-carbon triple bond. The simplest acyclic alkynes with only ... ISBN 978-1-4058-5345-3. Alkyne. Encyclopædia Britannica Callister, W. D. "Materials Science and Engineering: An Introduction" ...
https://en.wikipedia.org/wiki/Glossary_of_engineering
Glossary of civil engineeringGlossary of civil engineering
Alkyne - In organic chemistry, an alkyne is an unsaturated hydrocarbon containing at least one carbon-carbon triple bond. Alloy ... ISBN 978-1-4058-5345-3. Alkyne. Encyclopædia Britannica Callister, W. D. "Materials Science and Engineering: An Introduction" ...
https://en.wikipedia.org/wiki/Glossary_of_civil_engineering
Organozirconium chemistryOrganozirconium chemistry
Substrates for hydrozirconation are alkenes and alkynes. Terminal alkynes give vinyl complexes. Secondary reactions are ...
https://en.wikipedia.org/wiki/Organozirconium_chemistry
CarbometalationCarbometalation
Trimethyl Silyl (TMS) protected alkynes, trimethyl germanium alkynes, and terminal alkynes can produce anti-carboalumination ... This zirconium cation can coordinate an alkene or alkyne where migratory insertion of a methyl then takes place. The resultant ... Carbometalations can be performed on alkynes and alkenes to form products with high geometric purity or enantioselectivity, ... Novel syntheses of .alpha.,.beta.-unsaturated cyclopentenones via allylzincation of alkynes". Journal of the American Chemical ...
https://en.wikipedia.org/wiki/Carbometalation
Organogold chemistryOrganogold chemistry
In 1991, Utimoto reacted gold(III) (NaAuCl4) with alkynes and water. Teles identified a major drawback of this method as Au(III ... Norman, R. O. C.; Parr, W. J. E.; Thomas, C. B. (1976). "The reactions of alkynes, cyclopropanes, and benzene derivatives with ... Cationic gold(I) forms π-complexes with alkene or alkyne bonds, following the Dewar-Chatt-Duncanson model. Gold is certainly ... For instance, Hashmi reported an AuCl3-catalyzed alkyne / furan Diels-Alder reaction - a type of cycloaddition that does not ...
https://en.wikipedia.org/wiki/Organogold_chemistry
AlkaneAlkane
... alkynes, haloalkanes, alcohols, aldehydes and ketones and carboxylic acids. When alkenes and alkynes are subjected to ... Alkene Alkyne Cycloalkane Higher alkanes IUPAC, Compendium of Chemical Terminology, 2nd ed. (the "Gold Book") (1997). Online ... Arora, A. (2006). Hydrocarbons (Alkanes, Alkenes And Alkynes). Discovery Publishing House Pvt. Limited. ISBN 9788183561426. On- ... thereby leading to the addition of hydrogen on alkenes and alkynes. The reaction is exothermic because the product alkane is ...
https://en.wikipedia.org/wiki/Alkane
Seyferth-Gilbert homologationSeyferth-Gilbert homologation
The generation of nitrogen gas gives a vinyl carbene G, which via a 1,2-migration forms the desired alkyne H. The dimethyl ( ... A facile synthesis of alkynes". J. Org. Chem. 47 (10): 1837-1845. doi:10.1021/jo00349a007. D. G. Brown; E. J. Velthuisen; J. R ... S. Müller; B. Liepold; G. Roth & H. J. Bestmann (1996). "An Improved One-pot Procedure for the Synthesis of Alkynes from ... Reaction of Bestmann's reagent with aldehydes gives terminal alkynes often in very high yield and fewer steps than the Corey- ...
https://en.wikipedia.org/wiki/Seyferth–Gilbert_homologation
HydroaminationHydroamination
... is the addition of an N-H bond of an amine across a carbon-carbon multiple bond of an alkene, alkyne, diene, or ... The four main categories are (1) nucleophilic attack on an alkene alkyne, or allyl ligand and (2) insertion of the alkene into ... Müller, T. E. Beller, M. (1998). "Metal-Initiated Amination of Alkenes and Alkynes". Chemical Reviews. 98 (2): 675-704. doi: ... Pohlki, F., Doye, S. (2003). "The catalytic hydroamination of alkynes". Chemical Society Reviews. 32 (2): 104-114. doi:10.1039/ ...
https://en.wikipedia.org/wiki/Hydroamination
Diphosphorus tetrafluorideDiphosphorus tetrafluoride
Other kinds of alkynes produced polymers with this treatment. With alkenes, similarly bis(difluorophosphino) is added across ... Under ultraviolet light diphosphorus tetrafluoride reacts with alkynes connected to trifluoromethyl groups to add ... "Photoreactions of tetrafluorodiphosphine with alkynes". Journal of Fluorine Chemistry. 40 (1): 41-49. doi:10.1016/S0022-1139(00 ...
https://en.wikipedia.org/wiki/Diphosphorus_tetrafluoride
Chloroplatinic acidChloroplatinic acid
Lewis, L. N.; Sy, K. G.; Bryant, G. L.; Donahue, P. E. (1991). "Platinum-catalyzed hydrosilylation of alkynes". Organometallics ...
https://en.wikipedia.org/wiki/Chloroplatinic_acid
Organophosphorus compoundOrganophosphorus compound
Base is not required for electron-deficient alkenes (e.g., derivatives of acrylonitrile) and alkynes. Under free-radical ... "Nucleophilic and free-radical additions of phosphines and phosphine chalcogenides to alkenes and alkynes". Arkivoc. v (5): 12- ...
https://en.wikipedia.org/wiki/Organophosphorus_compound
2-Octyne2-Octyne
... , also known as methylpentylethin and oct-2-yne,[1] is a type of alkyne with a triple bond at its second carbon (the '2 ...
https://en.wikipedia.org/wiki/2-Octyne
Polycyclic aromatic hydrocarbonPolycyclic aromatic hydrocarbon
Alkynes. CnH2n − 2. Linear alkynes. *Ethyne. *Propyne. *Butyne ...
https://en.wikipedia.org/wiki/Polycyclic_aromatic_hydrocarbon
1-Methylcyclopropene1-Methylcyclopropene
Alkynes. CnH2n − 2. Linear alkynes. *Ethyne. *Propyne. *Butyne ...
https://en.wikipedia.org/wiki/1-Methylcyclopropene
Sonogashira couplingSonogashira coupling
Various aromatic alkynes can be employed to yield desired disubstituted products with satisfactorily yields. Aliphatic alkynes ... It is suggested that the presence of a base results in the formation of a π-alkyne complex E. This increases the acidity of the ... It employs a palladium catalyst as well as copper co-catalyst to form a carbon-carbon bond between a terminal alkyne and an ... Copper(I) salts, such as CuI, react with the terminal alkyne and produce a copper(I) acetylide, which acts as an activated ...
https://en.wikipedia.org/wiki/Sonogashira_coupling
HydrostannylationHydrostannylation
The typical Pd-based catalyst is tetrakis(triphenylphosphine)palladium(0). The typical unsaturated substrates are alkynes. The ...
https://en.wikipedia.org/wiki/Hydrostannylation
Zinc triflateZinc triflate
R. J. Rahaim & J. T. Shaw (2008). "Zinc-Catalyzed Silylation of Terminal Alkynes". J. Org. Chem. 73 (7): 2912-2915. doi:10.1021 ... "Silylation of 1-alkynes with chlorosilanes promoted by Zn(OTf)2: an efficient way to the preparation of alkynylsilanes". ...
https://en.wikipedia.org/wiki/Zinc_triflate
BoroleBorole
The reaction with the electron-poor alkyne (C 6F 5)CC(C 6F 5) required rather harsh reaction conditions (110 °C, 7 days) and ... In that study, 2 was reacted with three differently substituted alkynes that greatly differed in their electronic properties, ... towards alkynes in great detail. Of particular relevance was the question of whether the enhanced Lewis acidity of 2 compared 1 ... The potent Lewis acidity of 12 revealed a novel reaction pathway whereby the alkyne first adds to the borole nucleophilically, ...
https://en.wikipedia.org/wiki/Borole
IminoboraneIminoborane
Like alkynes, iminoboranes bind transition metals. Paetzold, Peter; Plotho, Christoph Von; Schmid, Günter; Boese, Roland; ...
https://en.wikipedia.org/wiki/Iminoborane
1,2-Dibromoethylene1,2-Dibromoethylene
"Chapter 9: Addition Reactions of Alkynes". Organic Chemistry 4e Carey. McGraw-Hill. Archived from the original on April 12, ...
https://en.wikipedia.org/wiki/1,2-Dibromoethylene
Copper hydrideCopper hydride
Uehling, Mycah R.; Rucker, Richard P.; Lalic, Gojko (2014-06-18). "Catalytic Anti-Markovnikov Hydrobromination of Alkynes". ... and alkynes has only recently been recognized and has served as the basis for several copper-catalyzed formal ...
https://en.wikipedia.org/wiki/Copper_hydride
Alkyne - WikipediaAlkyne - Wikipedia
In the alkyne zipper reaction, alkynes are generated from other alkynes by treatment with a strong base. ... Naming alkynes[edit]. In systematic chemical nomenclature, alkynes are named with the Greek prefix system without any ... Terminal and internal alkynes[edit]. Internal alkynes feature carbon substituents on each acetylenic carbon. Symmetrical ... Cycloaddition processes involving alkynes are often catalyzed by metals, e.g. enyne metathesis and alkyne metathesis, which ...
https://en.wikipedia.org/wiki/Alkyne
Organic Chemistry 51B. Lecture 11. Alkynes, Part 3.Organic Chemistry 51B. Lecture 11. Alkynes, Part 3.
Alkynes, Part 3. Organic Chemistry (Chem 51B) is part of OpenChem: http://ocw.uci.edu/openchem/.html; This video is part of a ...
http://www.merlot.org/merlot/viewMaterial.htm?id=783304
Organometallic compound - Alkene and alkyne ligands | BritannicaOrganometallic compound - Alkene and alkyne ligands | Britannica
Alkene and alkyne ligands: An alkene ligand contains a π bond between carbon atoms, C=C, which can serve as an electron pair ... Alkene and alkyne ligands. An alkene ligand contains a π bond between carbon atoms, C=C, which can serve as an electron pair ...
https://www.britannica.com/science/organometallic-compound/Alkene-and-alkyne-ligands
Alkyne trimerisation - WikipediaAlkyne trimerisation - Wikipedia
An alkyne trimerisation reaction is a [2+2+2] cycloaddition reaction in which three alkyne units react to form a benzene ring. ... In terms of mechanism, the reactions begin with the formation of metal-alkyne complexes. The combination of two alkynes within ... Many variations have been developed including cyclisation of mixtures of alkynes and alkenes as well as alkynes and nitriles. ... benzannulation of enynes with alkynes, and Lewis-acid-mediated [4+2] cycloaddition of enynes with alkynes. Cyclization of ...
https://en.wikipedia.org/wiki/Alkyne_trimerisation
Alkenes and alkynes | Organic chemistry | Science | Khan AcademyAlkenes and alkynes | Organic chemistry | Science | Khan Academy
... and also learn about the vast possibility of reactions using alkenes and alkynes as starting materials. ... Alkenes and alkynes can be transformed into almost any other functional group you can name! We will review their nomenclature, ... Alkenes and alkynes can be transformed into almost any other functional group you can name! We will review their nomenclature, ... and also learn about the vast possibility of reactions using alkenes and alkynes as starting materials. ...
https://www.khanacademy.org/science/organic-chemistry/alkenes-alkynes/alkene-reactions/v/introduction-to-reaction-mechanisms?modal=1
Cyanine3 alkyne | AbcamCyanine3 alkyne | Abcam
... a yellow emitting fluorescent alkyne dye. Join researchers using high quality Cy3 alkyne from Abcam and achieve your mission, ... Yellow emitting fluorescent alkyne dye for click chemistry reactions. Analog of Cy3® alkyne. Can be attached to nearly any ... Size-matched alkyne-conjugated cyanine fluorophores to identify differences in protein glycosylation.. Electrophoresis 35:2621- ...
https://www.abcam.com/cyanine3-alkyne-ab146444.html
FSc Chemistry Book2, CH 8, LEC 25: Oxidation Reactions of Alkynes - Video DailymotionFSc Chemistry Book2, CH 8, LEC 25: Oxidation Reactions of Alkynes - Video Dailymotion
FSc Chemistry Book2, CH 8, LEC 25: Oxidation Reactions of Alkynes. 4 years ago2.7K. views ...
https://www.dailymotion.com/video/x1wudth
Synthesis of Alkynyl(aryl)iodonium salts from TMS-alkynesSynthesis of Alkynyl(aryl)iodonium salts from TMS-alkynes
Alkynes: NomenclatureAlkynes: Nomenclature
Although some common alkyne names, such as acetylene, are still found in many textbooks, the International Union of Pure and ... The rules for alkynes in this system are identical with those for alkenes, except for the ending. The following rules summarize ... Although some common alkyne names, such as acetylene, are still found in many textbooks, the International Union of Pure and ... The parent name of the alkyne comes from the IUPAC name for the alkane of the same number of carbon atoms, except the ‐ ane ...
https://www.cliffsnotes.com/study-guides/chemistry/organic-chemistry-i/alkynes/alkynes-nomenclature
Stereoselective cobalt-catalyzed halofluoroalkylation of alkynes - Chemical Science (RSC Publishing)Stereoselective cobalt-catalyzed halofluoroalkylation of alkynes - Chemical Science (RSC Publishing)
We report efficient cobalt-catalyzed (E)-halofluoroalkylations of alkynes/alkenes that enable the ... Stereoselective cobalt-catalyzed halofluoroalkylation of alkynes G. Wu and A. Jacobi von Wangelin, Chem. Sci., 2018, 9, 1795 ... We report efficient cobalt-catalyzed (E)-halofluoroalkylations of alkynes/alkenes that enable the construction of densely ...
https://pubs.rsc.org/en/content/articlelanding/2018/SC/C7SC04916A
Rhodium-catalyzed intramolecular alkynylsilylation of alkynes - Chemical Communications (RSC Publishing)Rhodium-catalyzed intramolecular alkynylsilylation of alkynes - Chemical Communications (RSC Publishing)
... representing the first alkynylsilylation of alkynes via the cleavage of a C(sp)-Si bond by transition-metal catalysis. A highly ... Rhodium-catalyzed intramolecular alkynylsilylation of alkynes is described. The reaction proceeds through syn-insertion by a ... Rhodium-catalyzed intramolecular alkynylsilylation of alkynes R. Shintani, H. Kurata and K. Nozaki, Chem. Commun., 2015, 51, ... Rhodium-catalyzed intramolecular alkynylsilylation of alkynes is described. The reaction proceeds through syn-insertion by a ...
https://pubs.rsc.org/en/content/articlelanding/2015/CC/c5cc04172d
Alkynes: Physical PropertiesAlkynes: Physical Properties
Alkynes are generally nonpolar molecules with little solubility in polar solvents, ... The physical properties of alkynes are very similar to those of the alkenes. ... The physical properties of alkynes are very similar to those of the alkenes. Alkynes are generally nonpolar molecules with ... Substituted alkynes have small dipole moments due to differences in electronegativity between the triple‐bonded carbon atoms, ...
https://www.cliffsnotes.com/study-guides/chemistry/organic-chemistry-i/alkynes/alkynes-physical-properties
hydration of alkyneshydration of alkynes
... Posted on November 19, 2020. A mild strategy for highly regioselective hydration of the alkynes (internal ... sulfate to our alkyne. Which form would you expect to be the most stable? that took a bond away from that carbon. In the second ... going to move and form a bond with this The H plus, add it over here on one side of our alkyne. here, and then the methyl group ... For terminal alkynes the addition of water follows the Markovnikov rule, as in the second example below, and the final product ...
https://diobeth.org/.tmb/forum/hwb0oig.php?e0ffba=hydration-of-alkynes
S,R,S)-AHPC-PEG5-Alkyne | Sigma-AldrichS,R,S)-AHPC-PEG5-Alkyne | Sigma-Aldrich
S,R,S)-AHPC-PEG5-Alkyne; Synonym: (2S,4R)-1-((S)-2-(tert-Butyl)-4-oxo-7,10,13,16,19-pentaoxa-3-azadocos-21-ynoyl)-4-hydroxy-N-( ... S,R,S)-AHPC-PEG5-Alkyne Synonym: (2S,4R)-1-((S)-2-(tert-Butyl). -. 4-. oxo-. 7,10,13,16,19-. pentaoxa-. 3-. azadocos-. 21- ... Protein degrader builiding block (S,R,S)-AHPC-PEG5-Alkyne enables the synthesis of molecules for targeted protein degradation ... S,R,S)-AHPC-C6-PEG3-butyl alkyne, ≥95% pricing ... other protein degrader building blocks with a pendant alkyne ...
https://www.sigmaaldrich.com/catalog/product/aldrich/901855?lang=en®ion=US
Nickel-loaded zeolite snags small alkynes from mixtures with olefinsNickel-loaded zeolite snags small alkynes from mixtures with olefins
... which forms complexes with alkynes when a gaseous olefin-alkyne mix passes through it. Using this material, the scientists were ... To eliminate alkynes, polymer makers typically partially hydrogenate them using palladium catalysts. But this method is ... When making polymers from lower olefins like ethylene, propylene, and 1,3-butadiene, its important to ensure no alkynes are in ... Nickel-loaded zeolite snags small alkynes from mixtures with olefins Inexpensive material could purify olefins for polymer ...
https://cen.acs.org/analytical-chemistry/separations/Nickel-loaded-zeolite-snags-small/98/i21
Why are alkenes and alkynes called unsaturated hydrocarbons? Why are alkanes called saturated hydrocarbons? | bartlebyWhy are alkenes and alkynes called unsaturated hydrocarbons? Why are alkanes called saturated hydrocarbons? | bartleby
6 - Name each alkyne:Ch. 6 - Name each alkyne: a.CH3CHCHCH2CH2CH3Ch. 6 - Name each alkyne:Ch. 6 - Name each alkyne: a. ... 6 - Why are alkenes and alkynes called unsaturated...Ch. 6 - What are the main properties of alkanes?Ch. 6 - If water is ... ChemistryChemistry In FocusWhy are alkenes and alkynes called unsaturated hydrocarbons? Why are alkanes called saturated ... Why are alkenes and alkynes called unsaturated hydrocarbons? Why are alkanes called saturated hydrocarbons? ...
https://www.bartleby.com/solution-answer/chapter-6-problem-12e-chemistry-in-focus-7th-edition/9781337399692/why-are-alkenes-and-alkynes-called-unsaturated-hydrocarbons-why-are-alkanes-called-saturated/17fb06c6-90e6-11e9-8385-02ee952b546e
Alkyne ReactivityAlkyne Reactivity
3. Hydration of Alkynes and Tautomerism. As with alkenes, the addition of water to alkynes requires a strong acid, usually ... The following problems review the chemistry of alkynes. The first question requires you to select one of two starting alkynes ... Addition Reactions of Alkynes. A carbon-carbon triple bond may be located at any unbranched site within a carbon chain or at ... For terminal alkynes the addition of water follows the Markovnikov rule, as in the second example below, and the final product ...
https://www2.chemistry.msu.edu/faculty/reusch/virttxtjml/addyne1.htm
27-alkyne cholesterol 27-alkyne cholesterol, powder | 1527467-07-727-alkyne cholesterol 27-alkyne cholesterol, powder | 1527467-07-7
27-alkyne cholesterol 27-alkyne cholesterol, powder; CAS Number: 1527467-07-7; find Avanti-700143P MSDS, related peer-reviewed ... This reagent is a modified lipid containing an omega-terminal alkyne. The terminal alkyne group can be used in a highly ... 27-alkyne cholesterol acts similar to natural sterols such as, ergosterol and cholesterol. ... Alkyne cholesterol is used to trace cholesterol metabolism and localization.. ...
https://www.sigmaaldrich.com/HK/zh/product/avanti/700143p
cy3 alkyne | edocrcy3 alkyne | edocr
Cyanine3 alkyne Catelog Number: R02-0021 Category: Alkynes ; Cyanine Home  Fluorescent Probes  Reactive Group  Alkynes ... Boc Sciences offers Cyanine3 alkyne in bulk, please inquire us to get a quote for Cyanine3 alkyne. ... Online Inquiry Name: Name Phone: Phone * Email: Email * Products or Services Interested: (R02-0021)Cyanine3 alkyne Resources ... Cyanine3 alkyne is a fluorophore ready for the use in Click Chemistry reaction.With this reagent, bright and photostable ...
https://www.edocr.com/v/bm71yln5/bocsci22/cy3-alkyne
Nomenclature for Alkyl Halides, Alcohols, Alkenes, and Alkynes | UniversalClassNomenclature for Alkyl Halides, Alcohols, Alkenes, and Alkynes | UniversalClass
For alkyne nomenclature, the -ene (or -ane) suffix is replaced by -yne. The simplest alkyne, C2H2, goes by the name ethyne or ... Alkynes: Nomenclature Alkynes are similar to alkenes, except they involve a triple bond between two carbons rather than a ... The same rules of alkene nomenclature apply to alkynes. If a double bond and triple bond both appear in the same molecule, the ... Below are two illustrative examples of alkyne nomenclature. Note in the molecule on the right, the double bond wins in the case ...
https://www.universalclass.com/articles/science/organic-chemistry/nomenclature-for-alkyl-halides-alcohols-alkenes-and-alkynes.htm
708d) Optimized Mie Potentials for Phase Equilibria: Application to Noble Gases, Alkanes, Alkynes and Their Mixtures | AIChE708d) Optimized Mie Potentials for Phase Equilibria: Application to Noble Gases, Alkanes, Alkynes and Their Mixtures | AIChE
708d) Optimized Mie Potentials for Phase Equilibria: Application to Noble Gases, Alkanes, Alkynes and Their Mixtures. ... For alkynes, experimental saturated liquid densities are reproduced to within 2% average absolute deviation (AAD), except for 1 ... Transferable united-atom force fields, based on n-6 Mie potentials are presented for noble gases, branched alkanes, and alkynes ... Alkynes, Ethers, and Alcohols. Industrial & Engineering Chemistry Research, 2004. 43(7): p. 1788-1793. ...
https://www.aiche.org/conferences/aiche-annual-meeting/2017/proceeding/paper/708d-optimized-mie-potentials-phase-equilibria-application-noble-gases-alkanes-alkynes-and-their
alkyl halide to alkynealkyl halide to alkyne
Deprotonation of a terminal alkyne, followed by reaction with an alkyl halide, to give an internal alkyne product. Also Known ... alkyl halide to alkyne. Posted on November 19, 2020. Draw the mechanism of this reactions as well. The alkylation of acetylide ... Solution for The product of the addition of HCl to an alkene is called a(n) a. alkane b. alkyne c. alkyl halide d. halo-alkene ... When there is the presence of a C-C triple bond in an unsaturated hydrocarbon, then such a compound is called alkynes. The ...
https://diobeth.org/.tmb/forum/hwb0oig.php?e0ffba=alkyl-halide-to-alkyne
Difference Between Alkanes, Alkenes and Alkynes | Difference BetweenDifference Between Alkanes, Alkenes and Alkynes | Difference Between
... alkenes and alkynes are all hydrocarbons with different structures and thus different physical and chemical properties. ... Alkynes. Alkynes are also unsaturated hydrocarbons; they have one or more triple bonds between the carbon atoms. Their general ... Alkanes, Alkenes vs Alkynes. Alkanes, alkenes and alkynes are all hydrocarbons with different structures and thus different ... They have remained unchanged for millions of years; alkenes are less stable than alkanes and more stable than alkynes; alkynes ...
http://www.differencebetween.net/science/chemistry-science/difference-between-alkanes-alkenes-and-alkynes/
Synthesis of Isoquinolines from α-Aryl Vinyl Azides and Internal Alkynes by Rh-Cu Bimetallic Cooperation - Wang - 2011 -...Synthesis of Isoquinolines from α-Aryl Vinyl Azides and Internal Alkynes by Rh-Cu Bimetallic Cooperation - Wang - 2011 -...
Synthesis of Isoquinolines from α-Aryl Vinyl Azides and Internal Alkynes by Rh-Cu Bimetallic Cooperation†. ... Synthesis of Isoquinolines from α-Aryl Vinyl Azides and Internal Alkynes by Rh-Cu Bimetallic Cooperation. Angew. Chem., 123: ...
http://onlinelibrary.wiley.com/doi/10.1002/ange.201101009/suppinfo
Materials | Free Full-Text | Synthesis of Dendronized Poly(l-Glutamate) via Azide-Alkyne Click ChemistryMaterials | Free Full-Text | Synthesis of Dendronized Poly(l-Glutamate) via Azide-Alkyne Click Chemistry
... catalyzed azide-alkyne cycloaddition reaction to form a 1,4-disubstituted triazole. The dendronization reaction proceeded ... Synthesis of Dendronized Poly(l-Glutamate) via Azide-Alkyne Click Chemistry by Peter Perdih. , Andrej Kržan and Ema Žagar * ... Perdih, P.; Kržan, A.; Žagar, E. Synthesis of Dendronized Poly(l-Glutamate) via Azide-Alkyne Click Chemistry. Materials 2016, 9 ... Perdih P, Kržan A, Žagar E. Synthesis of Dendronized Poly(l-Glutamate) via Azide-Alkyne Click Chemistry. Materials. 2016; 9(4): ...
https://www.mdpi.com/1996-1944/9/4/242
Copper-Catalyzed Oxidative Hydrosulfonylation of Alkynes Using Sodium Sulfinates in AirCopper-Catalyzed Oxidative Hydrosulfonylation of Alkynes Using Sodium Sulfinates in Air
Stereoselective Synthesis of (E)-Alkenyl Sulfones from Alkenes or Alkynes via Copper-Catalyzed Oxidation of Sodium Sulfinates ... Copper-Catalyzed Oxidative Hydrosulfonylation of Alkynes Using Sodium Sulfinates in Air. Nobukazu Taniguchi*. *Department of ... Copper-catalyzed hydrosulfonylations of both terminal and internal alkynes can be carried out using sodium sulfinates in air. ...
https://www.organic-chemistry.org/abstracts/lit3/649.shtm
Boiling point of Alkanes vs alkenes vs alkynes | Student Doctor NetworkBoiling point of Alkanes vs alkenes vs alkynes | Student Doctor Network
... alkenes and alkynes vary? Been searching for like 10 minutes, no luck here. Seems like it varies on a case... ... When comparing alkynes, alkenes, and alkanes of similar molecular weight and structure(unbranched), I am pretty sure alkynes ... When comparing alkynes, alkenes, and alkanes of similar molecular weight and structure(unbranched), I am pretty sure alkynes ... cycloalkanes,alkynes, cis alkenes,trans alkenes,alkanes,terminal alkenes. I just need to post the graph now... ...
https://forums.studentdoctor.net/threads/boiling-point-of-alkanes-vs-alkenes-vs-alkynes.649390/
Ligand-Free Ag(I)-Catalyzed Carboxylation of Terminal Alkynes with CO2Ligand-Free Ag(I)-Catalyzed Carboxylation of Terminal Alkynes with CO2
... Xiao Zhang, Wen-Zhen Zhang*, Xiang Ren, Lin-Lin Zhang ... propiolic acids was developed by AgI-catalyzed carboxylation of terminal alkynes using carbon dioxide as carboxylative agent ...
https://www.organic-chemistry.org/abstracts/lit3/271.shtm
Alkyne - WikipediaAlkyne - Wikipedia
In organic chemistry, an alkyne is an unsaturatit hydrocarbon containin at least ane carbon-carbon triple bond atween twa ... Taen frae "https://sco.wikipedia.org/w/index.php?title=Alkyne&oldid=733353" ...
https://sco.wikipedia.org/wiki/Alkyne
TerminalAlkanesAlkaneAcetyleneMoleculeReactiveReactivityClick chemistryReactionsHydrocarbonsAlkene or alkyneAzides and AlkynesReagentsCatalystCarbonCycloaddition reactionAlcoholsReaction of an alkyneCopperAtomsIUPACLigandComplexesAldehydesAcetylenesAlkenes or AlkynesHydration of AlkynesActivation of alkynesNomenclature of alkynesInternalCyclic alkynesPalladiumHydrogenationHydrogenChemistryContain alkyneAldehydeUnsymmetricalSodium amideBiomoleculesCompoundsFluorescentEnolMixturesCatalysisKetoneBondsSuffixUnsaturated hydrocarbonDerivativesArylRegioTriple bondAlkylFunctionalSaltsAcyclicMetathesis
Terminal42
  • Terminal alkynes have the formula RC 2 H. An example is methylacetylene (propyne using IUPAC nomenclature). (wikipedia.org)
  • Terminal alkynes, like acetylene itself, are mildly acidic, with p K a values of around 25. (wikipedia.org)
  • The acidic hydrogen on terminal alkynes can be replaced by a variety of groups resulting in halo-, silyl-, and alkoxoalkynes. (wikipedia.org)
  • The carbanions generated by deprotonation of terminal alkynes are called acetylides . (wikipedia.org)
  • Terminal alkynes have the formula RC2H. (wikipedia.org)
  • A mild strategy for highly regioselective hydration of the alkynes (internal and terminal) has been developed employing intramolecular ketone as the directing group under Ag(I) catalysis. (diobeth.org)
  • Let me just draw a terminal alkyne. (diobeth.org)
  • This reagent is a modified lipid containing an omega-terminal alkyne. (sigmaaldrich.com)
  • The terminal alkyne group can be used in a highly specific linking reaction with azide-containing reagents, known as 'click chemistry′, in the presence of a copper (Cu)-containing catalyst. (sigmaaldrich.com)
  • Deprotonation of a terminal alkyne, followed by reaction with an alkyl halide, to give an internal alkyne product. (diobeth.org)
  • Copper-catalyzed hydrosulfonylations of both terminal and internal alkynes can be carried out using sodium sulfinates in air. (organic-chemistry.org)
  • A convenient approach to selectively prepare a wide range of functionalized propiolic acids was developed by AgI-catalyzed carboxylation of terminal alkynes using carbon dioxide as carboxylative agent under ligand-free conditions. (organic-chemistry.org)
  • In terms of catalyst action, the authors hypothesize that terminal alkynes can penetrate the ligand shell and undergo hydrogenation to alkenes while other functional groups may not be able to penetrate the shell. (rsc.org)
  • Coupling of N-Tosylhydrazones with Terminal Alkynes Catalyzed by Copper(I) Synthesis of Trisubstituted Allenes. (docme.ru)
  • Zuschriften DOI: 10.1002/ange.201005741 Synthetic Methods Coupling of N-Tosylhydrazones with Terminal Alkynes Catalyzed by Copper(I): Synthesis of Trisubstituted Allenes** Qing Xiao, Ying Xia, Huan Li, Yan Zhang, and Jianbo Wang* Allenes are uniquely versatile intermediates in organic synthesis because of their structural and reactive properties that, in many cases, complement the chemistry of alkenes and alkynes. (docme.ru)
  • 7] Bertrand and co-workers have recently developed an efficient AuI complex that catalyzes the coupling of enamines and terminal alkynes to afford allene derivatives in good yields. (docme.ru)
  • Very recently, Kuang and Ma disclosed a breakthrough, which was based on the reaction of aldehydes, morpholine, and terminal alkynes mediated by ZnI2. (docme.ru)
  • Ogawa, Akiya 2014-04-27 00:00:00 To synthesize sulfur-containing π-conjugated polymers, reaction conditions for rhodium-catalyzed hydrothiolation of terminal alkynes with arenethiols are optimized in detail. (deepdyve.com)
  • Under the optimized conditions, rhodium-catalyzed hydrothiolation of terminal alkynes proceeds regio- and stereoselectively to afford the corresponding vinyl sulfides via an anti-Markovnikov and syn-addition process. (deepdyve.com)
  • An acetylide anion is formed by reaction of a terminal alkyne with sodium amide, which is a very strong base. (wikipremed.com)
  • A terminal alkyne is one of the most useful reactants for the synthesis of alkyne and alkene derivatives. (beilstein-journals.org)
  • Because an alkyne undergoes addition reaction at a C-C triple bond or cross-coupling at a terminal C-H bond. (beilstein-journals.org)
  • In this report, we found that the reaction of 3 equivalents of terminal alkyne 1 (aryl substituted alkyne) and an α-bromocarbonyl compound 2 (tertiary alkyl radical precursor) undergoes tandem alkyl radical addition/Sonogashira coupling to produce 1,3-enyne compound 3 possessing a quaternary carbon in the presence of a copper catalyst. (beilstein-journals.org)
  • Terminal alkynes are undoubtedly useful functional groups for organic synthesis, and they can undergo a variety of reactions [1] . (beilstein-journals.org)
  • The C-C triple bond of an alkyne is suitable for addition reactions, whereas the terminal hydrogen atom is a good target for cross-coupling by using Sonogashira and related coupling reactions [2-4] . (beilstein-journals.org)
  • Generally the synthesis of terminal alkyne and cyclic alkene ketal derivatives were performed fairly easily. (scielo.org.za)
  • The anionic monocarborane alkyne [12-(HC[triple bond, length as m-dash]C)-CB11H11]− was employed as a ligand towards Cu(I) to form terminal alkyne complexes. (uzh.ch)
  • In the present paper, the coupling reaction of aldehyde, terminal alkyne, amine salt and CO2 was investigated. (eurekaselect.com)
  • Subsequently, a copper-catalyzed coupling of aldehyde, terminal alkyne, diamine salt and CO2 was developed to generate a dioxazolidinone. (eurekaselect.com)
  • Djamila Teffahi, Smain Hocine and Chao-Jun Li, "Synthesis of Oxazolidinones, Dioxazolidinone and Polyoxazolidinone (A New Polyurethane) Via A Multi Component-Coupling of Aldehyde, Diamine Dihydrochloride, Terminal Alkyne and CO2", Letters in Organic Chemistry (2012) 9: 585. (eurekaselect.com)
  • A 1-alkyne is referred to as a terminal alkyne and alkynes at any other position are called internal alkynes. (litera4you.ru)
  • Zinc chloride and zinc triflate were successfully applied in the intermolecular hydroamination of terminal alkynes for the synthesis of various substituted indole derivatives, pyrazolines and pyrazoles, pyridazinones as well as amines. (uni-rostock.de)
  • Terminal alkynes and acetylene are fairly acidic and have pK a values (25) between that of ammonia (35) and ethanol (16). (chemeurope.com)
  • Terminal alkynes have a hydrogen atom bonded to at least one of the sp hybridized carbons (those involved in the triple bond. (chemeurope.com)
  • This paper describes a detailed computational study into the mechanism, as well as the region and stereoselectivity, observed in a recently reported transformation where MLC in a 16-electron iridium(III) phosphoramidate complex plays a critical role in directing the activation of terminal alkynes toward the generation of novel five-membered (E)-vinyloxyirida(III)cycles. (ubc.ca)
  • De novo biosynthesis is a recently developing and one of the most promising strategies for installing the terminal alkyne functionality into various molecular scaffolds, including diverse bioactive natural products, through the in situ generation and incorporation of the terminal alkyne functionality. (escholarship.org)
  • We recently elucidated an acyl carrier protein (ACP)-dependent alkyne biosynthetic pathway comprised of JamABC from Moorea producens JHB that produces a terminal alkyne-tagged polyketide using hexanoic acid as a starting substrate for terminal alkyne generation. (escholarship.org)
  • In the presence of a cationic gold(I) catalyst and N-halosuccinimide, both trimethylsilyl-protected and terminal alkynes are converted into alkynyl halides. (ucl.ac.uk)
  • Further experiments showed that silyl-protected alkynes undergo electrophilic iodination and bromination under Brønsted acid catalysis, whilst terminal alkynes require a cationic gold catalyst. (ucl.ac.uk)
  • The reaction of a terminal alkyne (RCCH) and 2- aminopyridine (R′C5NH3NH2) with the dinuclear species [Cp*IrCl2]2 afforded the cationic aminocarbene derivatives Cp*Ir(Cl)[ C- (CH2R)NHC5NH3R′] via a hydroamination and a ligand substitution. (ntu.edu.sg)
  • explain why it is necessary to use a bulky, sterically hindered borane when preparing vinylic boranes from terminal alkynes. (libretexts.org)
  • predict the product formed when the vinylic borane produced from a terminal alkyne is treated with basic hydrogen peroxide. (libretexts.org)
Alkanes14
  • Like the alkanes and alkenes, alkynes of four or fewer carbon atoms tend to be gases. (cliffsnotes.com)
  • From the heats of hydrogenation, shown in blue in units of kcal/mole, it would appear that alkynes are thermodynamically less stable than alkenes to a greater degree than alkenes are less stable than alkanes. (msu.edu)
  • Transferable united-atom force fields, based on n-6 Mie potentials are presented for noble gases, branched alkanes, and alkynes. (aiche.org)
  • Alkanes, alkenes and alkynes are all hydrocarbons with different structures and thus different physical and chemical properties. (differencebetween.net)
  • saturated hydrocarbons or alkanes, unsaturated hydrocarbons or alkenes and alkynes, cycloalkanes, and aromatic hydrocarbons or arenes. (differencebetween.net)
  • Alkenes have the pi bond between the carbon atoms, and during a lot of reactions the pi bond ruptures in order to form a single bond thus they are more reactive than alkanes but relatively stable as compared to alkynes. (differencebetween.net)
  • How do the boiling points of comparable alkanes, alkenes and alkynes vary? (studentdoctor.net)
  • When comparing alkynes, alkenes, and alkanes of similar molecular weight and structure(unbranched), I am pretty sure alkynes will have the highest boiling point due to the fact of increased electron density from your pi orbitals. (studentdoctor.net)
  • 5. Alkynes will have a higher BP than alkenes or alkanes. (studentdoctor.net)
  • What is the difference in alkanes, alkenes, and alkynes? (lessonplanet.com)
  • We present all type of solution for problems related to the Alkanes, Alkenes, Alkynes and Alcohols. (assignmenthelp.net)
  • Assignmenthelp.net not only provide help for assignment, project, and homework but also support student for learning the Alkanes, Alkenes, Alkynes and Alcohols in very effective way. (assignmenthelp.net)
  • Online tutorial facility is also available for those students who wish to learn the Alkanes, Alkenes, Alkynes and Alcohols. (assignmenthelp.net)
  • Unlike alkanes , and to a lesser extent, alkenes , alkynes are unstable and reactive. (chemeurope.com)
Alkane9
  • The parent name of the alkyne comes from the IUPAC name for the alkane of the same number of carbon atoms, except the ‐ ane ending is changed to ‐ yne to signify the presence of a triple bond. (cliffsnotes.com)
  • A less efficient catalyst, Lindlar's catalyst , prepared by deactivating (or poisoning) a conventional palladium catalyst by treating it with lead acetate and quinoline, permits alkynes to be converted to alkenes without further reduction to an alkane. (msu.edu)
  • However, careful hydrogenation of an alkyne proceeds exclusively to the alkene until the former is consumed, at which point the product alkene is very rapidly hydrogenated to an alkane. (msu.edu)
  • Solution for The product of the addition of HCl to an alkene is called a(n) a. alkane b. alkyne c. alkyl halide d. halo-alkene ◈ Carbon tetrachloride is used to detect neutrinos. (diobeth.org)
  • Information about how to use the RightsLink permission system can be found at Find answers to questions asked by student like you, The product of the addition of HCl to an alkene is called a(n) a. alkane b. alkyne c. alkyl halide d. halo-alkene. (diobeth.org)
  • Alkyne has 4 fewer hydrogens than an alkane. (slideserve.com)
  • The chiral column high-performance liquid chromatography (HPLC) method in general could not be directly used to resolve such substrates, since the differentiation of the alkyne segment with the other alkane/alkene segment is not significant in the stationary phase, and the alkyne group is not a good UV chromophore. (mdpi.com)
  • Classify each of the hydrocarbons in Problem 13-1 as an alkane, alkene, or alkyne. (bartleby.com)
  • Higher alkenes and alkynes are named by counting the number of carbons in the longest continuous chain that includes the double or triple bond and appending an -ene alkene or -yne alkyne suffix to the stem name of the unbranched alkane having that number of carbons. (litera4you.ru)
Acetylene7
  • Alkynes are traditionally known as acetylenes, although the name acetylene also refers specifically to C 2 H 2 , known formally as ethyne using IUPAC nomenclature . (wikipedia.org)
  • Commercially, the dominant alkyne is acetylene itself, which is used as a fuel and a precursor to other compounds, e.g., acrylates. (wikipedia.org)
  • Although some common alkyne names, such as acetylene, are still found in many textbooks, the International Union of Pure and Applied Chemistry (IUPAC) nomenclature is required for journal articles. (cliffsnotes.com)
  • alkynes are also called acetylene. (differencebetween.net)
  • The deprotected dendron with an acetylene focal group was coupled to the pendant azide groups of the modified linear copolypeptide, P(Glu-N 3 ), in a Cu(I) catalyzed azide-alkyne cycloaddition reaction to form a 1,4-disubstituted triazole. (mdpi.com)
  • Acetylene is the only alkyne forming an aldehyde in this reaction. (assignmenthelp.net)
  • The alkynes are traditionally known as acetylenes or the acetylene series , although the name acetylene is also used to refer specifically to the simplest member of the series, known as ethyne (C 2 H 2 ) using formal IUPAC nomenclature. (chemeurope.com)
Molecule10
  • Hydration of alkynes begins similar to the hydration of alkenes through the addition of the first water molecule. (diobeth.org)
  • Subsequent transfer of hydrogen to the adsorbed alkyne proceeds slowly, relative to the corresponding hydrogen transfer to an adsorbed alkene molecule. (msu.edu)
  • The alkyne-tagged molecule is imaged using Raman microscopy that detects the strong Raman signal from the CC triple bond stretching vibration (~2120 cm -1 ). (spie.org)
  • Masanobu Uchiyama and Ryo Takita from the RIKEN Center for Sustainable Resource Science and researchers from the University of Tokyo have now devised a method for selectively adding boron atoms to opposite sides of an alkyne molecule. (phys.org)
  • When additional atomic groups are added to an organic compound such as an alkyne, which has two carbon -carbon triple bond sites, the added groups can attach to the triple bond sites such that they are oriented to one side of the molecule to form what is known as a cis configuration, or oriented in opposite directions to afford a trans structure. (phys.org)
  • There are lots of types of formulas and each of them should be used in different situations.This is shown on alkenes and alkynes.There is also a way how to resize a molecule shown. (zirael.org)
  • A symmetrical alkyne is an alkyne in whose molecule the triply bonded carbon atoms bear the same ligands. (libretexts.org)
  • An alkyne is a molecule made up entirely of carbon and hydrogen where one or more carbon atoms are connected by triple bonds. (thoughtco.com)
  • The general formula for an alkyne is C n H 2n-2 where n is the number of carbon atoms in the molecule. (thoughtco.com)
  • The chemical structures of the three isomers of the hexyne alkyne molecule: 1-hexyne, 2-hexyne and 3-hexyne. (thoughtco.com)
Reactive9
  • Like other hydrocarbons, alkynes are generally hydrophobic but tend to be more reactive. (wikipedia.org)
  • In some reactions, alkynes are less reactive than alkenes . (wikipedia.org)
  • Since alkynes adsorb more strongly to such catalytic surfaces than do alkenes, they preferentially occupy reactive sites on the catalyst. (msu.edu)
  • For use in bio-orthogonal labeling , Chromeo Dyes are offered as click-reactive azides or alkynes. (activemotif.com)
  • The present work investigated whether hyperconjugative assistance and H-bonding can be combined with strain activation for the design of even more reactive alkynes and whether reactivity can be turned "on demand. (biomedsearch.com)
  • The fluorescent Alexa Fluor® 594 Dibo alkyne is reactive with azides via a copper-free 'click chemistry' reaction. (thermofisher.com)
  • The alkyne group is separated from the oligo by an 8 carbon spacer arm, which serves to reduce steric interaction between the reactive group and the oligo and allows multiple sites to be used. (genelink.com)
  • As a result, the alkyne group is separated from the oligo by a spacer arm of varying length, which serves to reduce steric interaction between the reactive group and the oligo. (genelink.com)
  • The 5-TAMRA alkyne is reactive with azide via a copper-catalyzed click reaction that allows the subsequent visualization by fluorescence spectroscopy. (mobitec.com)
Reactivity4
  • EXPLAIN and DISCUSS the reactivity of alkynes in electrophilic addition reaction. (slideserve.com)
  • Moderating strain without sacrificing reactivity: Design of fast and tunable non-catalyzed alkyne-azide cycloadditions via stereoelectronically controlled transition state stabilization. (biomedsearch.com)
  • When stereoelectronic amplification is achieved by optimal positioning of σ-acceptors at the endocyclic bonds antiperiplanar to the breaking alkyne π-bonds, the stabilization of the bent alkyne geometry leads to a significant decrease in strain in cyclic alkynes without compromising their reactivity in alkyne-azide cycloadditions. (biomedsearch.com)
  • Herein, we report the Cu-catalyzed control of the reactivity of an alkyne (addition and coupling) undergoing tandem tertiary alkylation and alkynylation to produce a 1,3-enyne containing a quaternary carbon center with good regio- and stereoselectivity. (beilstein-journals.org)
Click chemistry9
  • Yellow emitting fluorescent alkyne dye for click chemistry reactions. (abcam.com)
  • This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand and a PEGylated crosslinker with pendant alkyne for click chemistry with an azide on the target ligand. (sigmaaldrich.com)
  • Copper-catalyzed azide-alkyne cycloaddition (click chemistry)-based detection of global pathogen-host AMPylation on self-assembled human protein mi. (nih.gov)
  • The Click-iT Alexa Fluor 555 sDIBO Alkyne for Antibody Labeling is optimized for easy attachment to azido modified antibodies using copper-free Click chemistry. (thermofisher.com)
  • Genetic encoding and labeling of aliphatic azides and alkynes in recombinant proteins via a pyrrolysyl-tRNA Synthetase/tRNA(CUA) pair and click chemistry. (harvard.edu)
  • Alkynes are a key component of click chemistry and used for a wide variety of applications including bioconjugation, selective tagging of protein modifications, and labeling of metabolites and drug targets. (figshare.com)
  • The HMBP and the alkyne functions act respectively as anchoring surface group and click chemistry functionality. (springer.com)
  • The presence of the alkyne allows the user to use Click Chemistry (a [3+2] cycloaddition reaction between alkynes and azides, using copper (I) iodide as a catalyst) to conjugate it to a variety of azide-containing labels/tags (e.g., fluorescent dyes, biotin, or oligos, with extremely high regioselectivity and efficiency (1,2). (genelink.com)
  • Here we report the synthesis of two alkyne-bearing linkers, the incorporation onto a ONs and the conjugation by click chemistry with a [18F]prosthetic group. (ac.be)
Reactions10
  • In terms of mechanism, the reactions begin with the formation of metal-alkyne complexes. (wikipedia.org)
  • Addition of a 1,5-diyne with an alkyne produces a benzocyclobutene, a strained structure that can then be induced to undergo further reactions. (wikipedia.org)
  • We will review their nomenclature, and also learn about the vast possibility of reactions using alkenes and alkynes as starting materials. (khanacademy.org)
  • Indeed, most of the alkene addition reactions discussed earlier also take place with alkynes, and with similar regio- and stereoselectivity. (msu.edu)
  • Since alkynes are thermodynamically less stable than alkenes, we might expect addition reactions of the former to be more exothermic and relatively faster than equivalent reactions of the latter. (msu.edu)
  • When the addition reactions of electrophilic reagents, such as strong Brønsted acids and halogens, to alkynes are studied we find a curious paradox. (msu.edu)
  • The reactions are even more exothermic than the additions to alkenes, and yet the rate of addition to alkynes is slower by a factor of 100 to 1000 than addition to equivalently substituted alkenes. (msu.edu)
  • There is also a difference between methyl crepenynate and methyl linoleate, in that the alkyne functionality seems to enhance the possibility of chain scission instead of addition reactions. (diva-portal.org)
  • Alkynes are involved in many organic reactions . (chemeurope.com)
  • Highly selective tandem nucleophilic addition/cross-coupling reactions of alkynes have been developed using visible-light-promoted dual gold/photoredox catalysis. (fu-berlin.de)
Hydrocarbons6
  • Like other hydrocarbons, alkynes are generally hydrophobic. (wikipedia.org)
  • We report efficient cobalt-catalyzed ( E )-halofluoroalkylations of alkynes/alkenes that enable the construction of densely functionalized, stereodefined fluorinated hydrocarbons. (rsc.org)
  • Why are alkenes and alkynes called unsaturated hydrocarbons? (bartleby.com)
  • alkynes are also unsaturated hydrocarbons with one or more triple bonds between the carbon atoms. (differencebetween.net)
  • Alkenes are hydrocarbons that contain one or more double bonds, while alkynes contain one or more triple bonds. (lumenlearning.com)
  • Alkynes are hydrocarbons that have at least one triple bond between two carbon atoms, with the formula C n H 2n-2 . (chemeurope.com)
Alkene or alkyne1
  • Before hydrogen can add to a multiple bond the alkene or alkyne must be adsorbed on the catalyst surface. (msu.edu)
Azides and Alkynes2
  • Chromeo™ Dye Azides and Alkynes are supplied lyophilized and should be stored at the recommended temperature in the dark. (activemotif.com)
  • Cycloaddition of Allylic Azides and Alkynes, 2. (ku.edu)
Reagents2
  • identify the reagents needed to convert a given alkyne to a given ketone. (libretexts.org)
  • identify the reagents, the alkyne, or both, needed to prepare a given ketone or a given cis alkene through a vinylic borane intermediate. (libretexts.org)
Catalyst5
  • Steric bulk on the alkyne coupling partners and catalyst have been invoked as the controlling elements of regioselectivity. (wikipedia.org)
  • The Lindlar catalyst permits adsorption and reduction of alkynes, but does not adsorb alkenes sufficiently to allow their reduction. (msu.edu)
  • Water adds to alkyne when alkyne is treated with 40% H2SO4 containing 1% HgSO4 (as a catalyst) to form a carbonyl compound. (assignmenthelp.net)
  • Recently, we have identified two strategies for selective transition state (TS) stabilization in catalyst-free azide/alkyne cycloadditions. (biomedsearch.com)
  • A continuous-flow synthesis for the Cu I -catalyzed azide-alkyne cycloaddition reaction using [Cu(phenanthroline)(PPh 3 ) 2 ]NO 3 as a homogeneous catalyst is developed (up to 92 % isolated yield). (syrris.com)
Carbon21
  • In organic chemistry , an alkyne is an unsaturated hydrocarbon containing at least one carbon-carbon triple bond . (wikipedia.org)
  • Internal alkynes feature carbon substituents on each acetylenic carbon. (wikipedia.org)
  • In the language of valence bond theory, the carbon atoms in an alkyne bond are sp hybridized: they each have two unhybridized p orbitals and two sp hybrid orbitals. (wikipedia.org)
  • 3. The position of the triple bond is indicated by placing the lower of the pair of numbers assigned to the triple‐bonded carbon atoms in front of the name of the alkyne. (cliffsnotes.com)
  • Substituted alkynes have small dipole moments due to differences in electronegativity between the triple‐bonded carbon atoms, which are sp hybridized, and the single‐bonded carbon atoms, which are sp 3 hybridized. (cliffsnotes.com)
  • In the case of catalytic hydrogenation, the usual Pt and Pd hydrogenation catalysts are so effective in promoting addition of hydrogen to both double and triple carbon-carbon bonds that the alkene intermediate formed by hydrogen addition to an alkyne cannot be isolated. (msu.edu)
  • Dr. Dietmar Kennepohl FCIC (Professor of Chemistry, Athabasca University), Prof. Steven Farmer (Sonoma State University), William Reusch, Professor Emeritus (Michigan State U. In organic chemistry, an alkyne is an unsaturated hydrocarbon containing at least one carbon-carbon triple bond. (diobeth.org)
  • In organic chemistry , an alkyne is an unsaturatit hydrocarbon containin at least ane carbon-carbon triple bond atween twa carbon atoms. (wikipedia.org)
  • Explanation: An alkyne is a common type of carbon compound with one carbon-to-carbon triple bond. (barrypopik.com)
  • Alkyne is a hydrocarbon that contains a carbon-carbon triple bond. (slideserve.com)
  • Alkynes are molecules that have a carbon-carbon triple bond. (assignmenthelp.net)
  • Figure 1: The three-dimensional structure of trans-diborylated alkyne, showing the position of boron (yellow), oxygen (red), carbon (gray) and hydrogen (white) atoms. (phys.org)
  • Methods to form two carbon-boron bonds on the same side of an alkyne, a procedure called cis-diborylation, have been described previously," explains Uchiyama, "but trans-diborylation has not been possible. (phys.org)
  • Here, we used alkyne containing a carbon-carbon triple bond as a Raman tag for observing small molecules in live cells. (spie.org)
  • Treatment of compound A with sodium amide converts it to compound B. Compound B on ozonol- ysis gives a diacid that retains all the carbon atoms of B. Compound B must therefore be a cyclic alkyne, formed by an intramolecular alkylation. (coursehero.com)
  • Alkene and alkyne compounds are named by identifying the longest carbon chain that contains both carbons of the double or triple bond. (lumenlearning.com)
  • Next, the position of the double or triple bond is indicated using the position of the carbon in the bond with the lower backbone number, and the suffix for the compound is changed to "-ene" for an alkene and "-yne" for an alkyne. (lumenlearning.com)
  • Although there are many reports on alkyne transformations, one recent development in this area has been the reaction of alkynes with tertiary alkyl electrophiles to produce functionalized quaternary carbon atoms via addition [5-10] or coupling [11-16] . (beilstein-journals.org)
  • The number corresponds to the first carbon of the triple bond of the alkyne. (thoughtco.com)
  • For example: 4-chlorodiiodomethylnonyne Rule 3 After numbering the longest chain with the lowest number assigned to the alkyne, label each of the substituents at its corresponding carbon. (litera4you.ru)
  • Internal alkynes have something other than hydrogen attached to the sp hybridized carbons, usually another carbon atom, but could be a heteroatom. (chemeurope.com)
Cycloaddition reaction1
  • An alkyne trimerisation reaction is a [2+2+2] cycloaddition reaction in which three alkyne units react to form a benzene ring. (wikipedia.org)
Alcohols1
  • Functionalizingpentacyclo[5.4.0.0 2,6 .0 3,10 .0 5,9 ]undecane-8-11-oneand 1-phenyl-pentacyclo[5.4.0.0 2,6 .0 3,10 .0 5,9 ]undecane-8-11-one can be easily accomplished by using the alcohols of various alkynes and alkenes. (scielo.org.za)
Reaction of an alkyne2
  • Similarly, Zhu's group has reported that the reaction of an alkyne and an α-bromocarbonyl compound furnishes a highly functionalized 1,3-enyne compound via ATRA followed by an alkynylation reaction [22] , but both Pd and Cu are required as catalysts in that case. (beilstein-journals.org)
  • write an equation for the reaction of an alkyne with borane. (libretexts.org)
Copper6
  • CF® dye alkyne reacts with azide to form 1,2,3-triazole by copper(I) catalyzed 1,3-dipolar Huisgen cycloaddition. (biotium.com)
  • CF® dye picolyl azide reacts with alkyne to form 1,2,3-triazole by 1,3-dipolar Huisgen cycloaddition through the use of a much lower copper (I) concentration without sacrificing reaction efficiency. (biotium.com)
  • Please consider this copper-free variation to our copper requiring alkynes if you are staining the surface of live cells or have concerns about native protein function loss with copper in cell extracts. (thermofisher.com)
  • It is also possible to form copper and silver alkynes, from this group of compounds silver acetylide is an often used example. (chemeurope.com)
  • The copper-catalyzed azide-alkyne cycloaddition click reaction is studied in one-pot eliminating the need to isolate and handle potentially explosive azide. (syrris.com)
  • The click reaction involves a copper-catalyzed triazole formation from an azide and an alkyne. (mobitec.com)
Atoms1
  • Uchiyama's team investigated whether diboron-two boron atoms -could be selectively added to an alkyne to form a trans arrangement (Fig. 1). (phys.org)
IUPAC1
  • In this alkenes and alkynes instructional activity, students name six structures using the IUPAC naming systems and they draw three organic molecules. (lessonplanet.com)
Ligand3
  • When used with other protein degrader building blocks with a pendant alkyne group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand. (sigmaaldrich.com)
  • Based on our findings, it is proposed that the reaction proceeds via a ligand-assisted proton shuttle (LAPS) mechanism, where the phosphoramidate phosphoryl (P=O) group assists in both alkyne C-H bond activation and C-H bond formation to form a vinylidene intermediate. (ubc.ca)
  • Many variables, including ligand class, sterics of the ligand and alkyne, temperature, and ring size being formed in intramolecular versions, all influence the extent of crossover observed. (escholarship.org)
Complexes3
  • Making use of easily-prepared stable alkyne-cobalt-complexes, we developed a simple and general method by analyzing the in situ generated cobalt-complex of chiral alkynes using chiral column HPLC. (mdpi.com)
  • Bonding Rearrangements of Hydrogen Bonded Complexes involving Alkynes E. S. Kryachko, S. Scheiner J. Phys. (usu.edu)
  • 3-Amino-1-ethoxyalkenylidene)pentacarbonylchromium complexes 2 react with alkynes in pyridine or acetonitrile to give highly substituted 5-amino-3-ethoxycyclopentadienes 3 as formal [3+2]-cycloadducts selectively in high yields rather than the usually favored [2+2+1]-cycloadducts, 5-methylene-2-cyclopenten-1-ones. (monash.edu)
Aldehydes3
  • Alkynes can be prepared from aldehydes using the Corey-Fuchs reaction and from aldehydes or ketones by the Seyferth-Gilbert homologation. (wikipedia.org)
  • The reaction mechanism for the palladium and amine cocatalyzed carbocyclization of aldehydes with alkynes has been investigated by means of density functional theory calculations and experiments. (diva-portal.org)
  • The mechanism of nickel(0)-catalyzed reductive coupling of aldehydes and alkynes has been studied. (escholarship.org)
Acetylenes1
  • Common nomenclature-alkynes are named as substituted acetylenes. (slideserve.com)
Alkenes or Alkynes1
  • We develop a short-route (one-pot) synthesis of this class of molecules by reacting thiols with alkenes or alkynes under mild and metal-free conditions. (ntu.edu.sg)
Hydration of Alkynes1
  • And then these We're going to add the OH minus So that's our Reaction: Hydration of Alkynes. (diobeth.org)
Activation of alkynes1
  • In this account, our two approaches to the metal-free synthesis of oxazoles by means of a peculiar activation of alkynes by iodine species is described with the related contexts. (eurekaselect.com)
Nomenclature of alkynes1
Internal4
  • We report a biocatalytic platform of engineered cytochrome P450 enzymes to carry out efficient cyclopropene synthesis via carbene transfer to internal alkynes. (caltech.edu)
  • Using an internal aliphatic alkyne bearing a propargylic ether group, different P411 variants can selectively catalyze cyclopropene formation, carbene insertion into a propargylic C-H bond or [3 + 2]-cycloaddition. (caltech.edu)
  • Alkyne C8 dT and dC can be used to incorporate an active alkyne onto the 5 - or 3 -end of an oligonucleotide, as well as at an internal position. (genelink.com)
  • For internal alkynes ( the triple-bond is within a longer chain ) the addition of water is not regioselective. (libretexts.org)
Cyclic alkynes1
Palladium4
  • Other methods for the direct formation of aromatic rings from substituted, unsaturated precursors include the Dötz reaction, palladium-catalyzed [4+2] benzannulation of enynes with alkynes, and Lewis-acid-mediated [4+2] cycloaddition of enynes with alkynes. (wikipedia.org)
  • To eliminate alkynes, polymer makers typically partially hydrogenate them using palladium catalysts. (acs.org)
  • A palladium-catalyzed multicomponent reaction of alkynes, carboxylic acids, and isocyanides has been developed with the assistance of silver salt under mild conditions. (figshare.com)
  • Alkynes can be selectively hydrogenated into alkenes on solid palladium catalysts. (gla.ac.uk)
Hydrogenation2
  • Alkenes and alkynes show a curious difference in behavior toward catalytic hydrogenation. (msu.edu)
  • Independent studies of hydrogenation rates for each class indicate that alkenes react more rapidly than alkynes. (msu.edu)
Hydrogen1
  • identify the ketone produced when a given alkyne is reacted with borane followed by basic hydrogen peroxide. (libretexts.org)
Chemistry8
  • I want to get the latest chemistry news from C&EN in my inbox every week. (acs.org)
  • Organic chemistry is difficult, those who study it have alkynes of trouble" was posted on Twitter on November 3, 2011. (barrypopik.com)
  • From what I've heard, organic chemistry students have alkynes of trouble with the class. (barrypopik.com)
  • Organic Chemistry is very difficult, those who take it have Alkynes of trouble. (barrypopik.com)
  • Alkynes also serve as important synthetic intermediates in a number of organic transformations, and their chemistry has recently received particular attention with respect to new materials. (docme.ru)
  • The 1,3-dipolar Huisgen azide-alkyne cycloaddition is a significant area of interest in modern chemistry. (ku.edu)
  • Akio Saito*, "Hypervalent Iodine-Mediated/Catalyzed Oxidative Cycloisomerization/Annulation of Alkynes for Metal-Free Synthesis of Oxazoles", Current Organic Chemistry (2020) 24: 1. (eurekaselect.com)
  • Notice how hydroboration complements hydration in the chemistry of both alkenes and alkynes. (libretexts.org)
Contain alkyne1
  • The resulting polymers, called polyacetylenes (which do not contain alkyne units) are conjugated and can exhibit semiconducting properties. (wikipedia.org)
Aldehyde2
  • Dimer involvement and origin of crossover in nickel-catalyzed aldehyde-alkyne reductive couplings. (escholarship.org)
  • identify the alkyne needed to prepare a given aldehyde by a vinylic borane. (libretexts.org)
Unsymmetrical2
  • Trimerisation of unsymmetrical alkynes gives two isomeric benzenes. (wikipedia.org)
  • Regioselective intermolecular trimerization of unsymmetrical alkynes remains an unsolved problem. (wikipedia.org)
Sodium amide1
  • For example, phenylacetylene can be generated from styrene by bromination followed by treatment of the resulting of styrene dibromide with sodium amide in ammonia: Via the Fritsch-Buttenberg-Wiechell rearrangement, alkynes are prepared from vinyl bromides. (wikipedia.org)
Biomolecules3
  • Alkyne tags can maintain original properties of target molecules with providing high chemical specificity owing to its distinct peak in a Raman-silent window of biomolecules. (spie.org)
  • To address this critical need, a novel brominated coumarin azide was used to tag alkynes and detect alkyne-conjugated biomolecules. (figshare.com)
  • Here we highlight our recent results of the application of ring-closing metathesis and ring-closing alkyne metathesis (RCAM) in biologically relevant biomolecules in order to introduce alkene- and/or alkyne-bridges as novel covalent constraints for stabilizing their bioactive conformation and increasing their metabolic stability. (gla.ac.uk)
Compounds1
  • New 20-hydroxycholesterol-like compounds with fluorescent NBD or alkyne labels: Synthesis, in silico interactions with proteins and uptake by yeast cells. (sigmaaldrich.com)
Fluorescent2
  • Yellow emitting fluorescent alkyne dye. (abcam.com)
  • To avoid the use of bulky fluorescent labels, we introduce a technique that uses a simple small chemical tag called alkyne consisting of two carbons connected by a triple bond. (spie.org)
Enol1
  • The initial product from the addition of water to an alkyne is an enol (a compound having a hydroxyl substituent attached to a double-bond), and this immediately rearranges to the more stable keto tautomer. (libretexts.org)
Mixtures1
  • Many variations have been developed including cyclisation of mixtures of alkynes and alkenes as well as alkynes and nitriles. (wikipedia.org)
Catalysis1
  • Teaching old dogs new tricks: Visible light photoredox catalysis improves the classic Meerwein arylation protocol significantly and allows the light-controlled arylation of alkenes, alkynes and enones by diazonium salts. (uni-regensburg.de)
Ketone2
  • predict the structure of the ketone formed when a given alkyne reacts with sulfuric acid in the presence of mercury(II) sulfate. (libretexts.org)
  • identify the alkyne needed to prepare a given ketone by hydration of the triple bond. (libretexts.org)
Bonds1
  • [2] Possible explanations involve the two π-bonds in the alkyne delocalising, which would reduce the energy of the π-system [ citation needed ] or the stability of the intermediates during the reaction. (wikipedia.org)
Suffix2
  • The longest continuous chain with functional group is no in the direction that gives the alkyne functional group suffix as low no as possible. (slideserve.com)
  • The suffix of the compound is "-ene" for an alkene or "-yne" for an alkyne. (lumenlearning.com)
Unsaturated hydrocarbon1
  • When there is the presence of a C-C triple bond in an unsaturated hydrocarbon, then such a compound is called alkynes. (diobeth.org)
Derivatives3
  • Base-Induced Condensation of -Chloro Oxime Derivatives Furnishes Alkynes. (docme.ru)
  • Angewandte Chemie Synthetic Methods Base-Induced Condensation of a-Chloro Oxime Derivatives Furnishes Alkynes** tion of 7 a is rationalized by assuming the fragmentation of an intermediate 1-aza-2-chlorobicyclo[1.1.0]butane 5 a (Scheme 2). (docme.ru)
  • Reduction of the alkyne ketal derivatives using Pd/CaCO 3 has been demonstrated to form a mixture containing the desired alkene ketal derivatives. (scielo.org.za)
Aryl1
  • The substrate scope is broad, covering (hetero)aryl-, alkynyl-, and aminocarbonyl-substituted alkenes, (hetero)aryl and alkyl as well as silyl alkynes, and tertiary to primary alkyl radical precursors with excellent functional group compatibility. (diobeth.org)
Regio1
  • In addition to high-order polymers and dimers and trimers, which originate from low regio- and chemoselectivities, enyne side products derived from alkyne dimerisation have been observed. (wikipedia.org)
Triple bond2
  • [1] The simplest acyclic alkynes with only one triple bond and no other functional groups form a homologous series with the general chemical formula C n H 2 n −2 . (wikipedia.org)
  • Alkenes and alkynes are named by identifying the longest chain that contains the double or triple bond. (lumenlearning.com)
Alkyl3
  • Alkynes are prepared from 1,2- and 1,1-alkyl dihalides by double dehydrohalogenation. (wikipedia.org)
  • Moreover, the reaction of α-bromocarbonyl compound 2 and an alkyne 4 possessing a carboxamide moiety undergoes tandem alkyl radical addition/C-H coupling to produce indolinone derivative 5 . (beilstein-journals.org)
  • Alkynes are generally prepared by dehydrohalogenation of vicinal alkyl dihalides or the reaction of metal acetylides with primary alkyl halides. (chemeurope.com)
Functional2
  • Alkenes and alkynes can be transformed into almost any other functional group you can name! (khanacademy.org)
  • However, little is known about ACP interactions with the other alkyne biosynthetic enzymes in the JamABC pathway, including an acyl-ACP ligase (JamA) and a membrane-bound bi-functional desaturase/acetylenase (JamB). (escholarship.org)
Salts1
  • Building up on our prior studies in titanium-catalyzed hydroamination of alkynes we discovered zinc salts as new hydroamination catalysts. (uni-rostock.de)
Acyclic1
  • The general molecular formula for an acyclic alkyne is CnH2n-2 and for cyclic alkyne is CnH2n-4. (slideserve.com)
Metathesis1
  • Part II of this Dissertation describes the synthesis of a molecular Möbius strip under alkyne metathesis with kinetic diastereoselectivity. (illinois.edu)
Mass spectral interpretation - Wikipedia
Mass spectral interpretation - Wikipedia (en.wikipedia.org)
Hydrocarbon | Encyclopedia.com
Hydrocarbon | Encyclopedia.com (encyclopedia.com)
Chemical compound - Functional groups | Britannica
Chemical compound - Functional groups | Britannica (britannica.com)
Alkynes Archives - Fuel Catalyst
Alkynes Archives - Fuel Catalyst (rentar.com)
Ester - Wikipedia
Ester - Wikipedia (en.wikipedia.org)
Activation of remote meta -C-H bonds assisted by an end-on template | Nature
Activation of remote meta -C-H bonds assisted by an end-on template | Nature (nature.com)
CH Chapter 8 - Alkenes, Alkynes and Aromatic Compounds - Chemistry
CH Chapter 8 - Alkenes, Alkynes and Aromatic Compounds - Chemistry (dyhywunerivuqalex.regardbouddhiste.com)
Synthesis and pre-clinical evaluation of a new class of high-affinity 18F-labeled PSMA ligands for detection of prostate cancer...
Synthesis and pre-clinical evaluation of a new class of high-affinity 18F-labeled PSMA ligands for detection of prostate cancer... (link.springer.com)
The enthalpy change for a reaction that occurs at | bartleby
The enthalpy change for a reaction that occurs at | bartleby (bartleby.com)
Scalable synthesis of sequence-defined, unimolecular macromolecules by Flow-IEG | PNAS
Scalable synthesis of sequence-defined, unimolecular macromolecules by Flow-IEG | PNAS (pnas.org)
Name two strategies for decreasing a school-age childs | bartleby
Name two strategies for decreasing a school-age childs | bartleby (bartleby.com)
Harnessing non-covalent interactions to exert control over regioselectivity and site-selectivity in catalytic reactions -...
Harnessing non-covalent interactions to exert control over regioselectivity and site-selectivity in catalytic reactions -... (pubs.rsc.org)
Chemistry Problem on Alkanes, Alkenes, Alkynes: Cyclobutane and Butene - Lakshan Dumpa | Brilliant
Chemistry Problem on Alkanes, Alkenes, Alkynes: Cyclobutane and Butene - Lakshan Dumpa | Brilliant (brilliant.org)
Solid-phase synthesis and chemical space analysis of a 190-membered alkaloid/terpenoid-like library | PNAS
Solid-phase synthesis and chemical space analysis of a 190-membered alkaloid/terpenoid-like library | PNAS (pnas.org)
Topological chiral crystals with helicoid-arc quantum states | Nature
Topological chiral crystals with helicoid-arc quantum states | Nature (nature.com)
Stereoselective cobalt-catalyzed halofluoroalkylation of alkynes - Chemical Science (RSC Publishing)
Stereoselective cobalt-catalyzed halofluoroalkylation of alkynes - Chemical Science (RSC Publishing) (pubs.rsc.org)
Rhodium-catalyzed intramolecular alkynylsilylation of alkynes - Chemical Communications (RSC Publishing)
Rhodium-catalyzed intramolecular alkynylsilylation of alkynes - Chemical Communications (RSC Publishing) (pubs.rsc.org)
27-alkyne cholesterol 27-alkyne cholesterol, powder | 1527467-07-7
27-alkyne cholesterol 27-alkyne cholesterol, powder | 1527467-07-7 (sigmaaldrich.com)
Learn Organic Chemistry Nomenclature 1 dans l'App Store
Learn Organic Chemistry Nomenclature 1 dans l'App Store (itunes.apple.com)
1-Methylcyclopropene - Wikipedia
1-Methylcyclopropene - Wikipedia (en.wikipedia.org)
Haloalkane - Wikipedia
Haloalkane - Wikipedia (en.m.wikipedia.org)
Hexane - Wikipedia
Hexane - Wikipedia (en.wikipedia.org)
Germane - Wikipedia
Germane - Wikipedia (en.wikipedia.org)
Organic Chemistry Bonding
Organic Chemistry Bonding (brainmass.com)
Palladium-catalyzed cascade carboesterification of norbornene with alkynes - Organic & Biomolecular Chemistry (RSC Publishing)
Palladium-catalyzed cascade carboesterification of norbornene with alkynes - Organic & Biomolecular Chemistry (RSC Publishing) (pubs.rsc.org)
Answer the questions below concerning ground state | bartleby
Answer the questions below concerning ground state | bartleby (bartleby.com)
Recent advances in catalytic asymmetric intermolecular oxidation of alkynes - Organic & Biomolecular Chemistry (RSC Publishing)
Recent advances in catalytic asymmetric intermolecular oxidation of alkynes - Organic & Biomolecular Chemistry (RSC Publishing) (pubs.rsc.org)
Zeitschrift für Naturforschung B
Zeitschrift für Naturforschung B (degruyter.com)
Search Results - AccessScience from McGraw-Hill Education
Search Results - AccessScience from McGraw-Hill Education (accessscience.com)
A new class of ratiometric small molecule intracellular pH sensors for Raman microscopy - Analyst (RSC Publishing) DOI:10...
A new class of ratiometric small molecule intracellular pH sensors for Raman microscopy - Analyst (RSC Publishing) DOI:10... (pubs.rsc.org)
Interpretation of the Ultraviolet Spectra of Natural Products - 1st Edition
Interpretation of the Ultraviolet Spectra of Natural Products - 1st Edition (elsevier.com)
Organic Chemistry, 2nd Edition | Organic Chemistry | Chemistry | Subjects | Wiley
Organic Chemistry, 2nd Edition | Organic Chemistry | Chemistry | Subjects | Wiley (wiley.com)
Relativistic effects in homogeneous gold catalysis | Nature
Relativistic effects in homogeneous gold catalysis | Nature (nature.com)
Understanding Organic Chemistry: 9 Steps
Understanding Organic Chemistry: 9 Steps (instructables.com)