Alkaline Ceramidase: A ceramidase subtype that is active at alkaline pH. It is found at high levels within the SMALL INTESTINE.Ceramidases: Amidohydrolases that are specific for the cleavage of the N-acyl linkage of CERAMIDES. Ceramidases are classified as acidic, neutral or basic according to the optimal pH with which they function.Acid Ceramidase: A ceramidase subtype that is active at acid pH. It plays an important role in sphingolipid degradation by catalyzing the lysosomal hydrolysis of ceramide to sphingosine and free fatty acid. Inherited deficiency of acid ceramidase activity results in FARBER LIPOGRANULOMATOSIS.Neutral Ceramidase: A ceramidase subtype that is active at neutral pH. It is found at high levels within the SMALL INTESTINE and in the BRAIN.Galactosylgalactosylglucosylceramidase: An enzyme that catalyzes the hydrolysis of a ceramidetrihexoside to a ceramidedihexoside plus galactose.AmidohydrolasesCeramides: Members of the class of neutral glycosphingolipids. They are the basic units of SPHINGOLIPIDS. They are sphingoids attached via their amino groups to a long chain fatty acyl group. They abnormally accumulate in FABRY DISEASE.Sphingosine: An amino alcohol with a long unsaturated hydrocarbon chain. Sphingosine and its derivative sphinganine are the major bases of the sphingolipids in mammals. (Dorland, 28th ed)Substrate Specificity: A characteristic feature of enzyme activity in relation to the kind of substrate on which the enzyme or catalytic molecule reacts.Energy Metabolism: The chemical reactions involved in the production and utilization of various forms of energy in cells.Sphingolipids: A class of membrane lipids that have a polar head and two nonpolar tails. They are composed of one molecule of the long-chain amino alcohol sphingosine (4-sphingenine) or one of its derivatives, one molecule of a long-chain acid, a polar head alcohol and sometimes phosphoric acid in diester linkage at the polar head group. (Lehninger et al, Principles of Biochemistry, 2nd ed)Epidermis: The external, nonvascular layer of the skin. It is made up, from within outward, of five layers of EPITHELIUM: (1) basal layer (stratum basale epidermidis); (2) spinous layer (stratum spinosum epidermidis); (3) granular layer (stratum granulosum epidermidis); (4) clear layer (stratum lucidum epidermidis); and (5) horny layer (stratum corneum epidermidis).Gastroenterology: A subspecialty of internal medicine concerned with the study of the physiology and diseases of the digestive system and related structures (esophagus, liver, gallbladder, and pancreas).Pediatrics: A medical specialty concerned with maintaining health and providing medical care to children from birth to adolescence.Food Inspection: Examination of foods to assure wholesome and clean products free from unsafe microbes or chemical contamination, natural or added deleterious substances, and decomposition during production, processing, packaging, etc.Celiac Disease: A malabsorption syndrome that is precipitated by the ingestion of foods containing GLUTEN, such as wheat, rye, and barley. It is characterized by INFLAMMATION of the SMALL INTESTINE, loss of MICROVILLI structure, failed INTESTINAL ABSORPTION, and MALNUTRITION.PaintingsAsparaginase: A hydrolase enzyme that converts L-asparagine and water to L-aspartate and NH3. EC 3.5.1.1.History, 16th Century: Time period from 1501 through 1600 of the common era.Bone Marrow Neoplasms: Neoplasms located in the bone marrow. They are differentiated from neoplasms composed of bone marrow cells, such as MULTIPLE MYELOMA. Most bone marrow neoplasms are metastatic.Sarcoma, Ewing: A malignant tumor of the bone which always arises in the medullary tissue, occurring more often in cylindrical bones. The tumor occurs usually before the age of 20, about twice as frequently in males as in females.Bone Marrow: The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.Ifosfamide: Positional isomer of CYCLOPHOSPHAMIDE which is active as an alkylating agent and an immunosuppressive agent.Etoposide: A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle.Antineoplastic Combined Chemotherapy Protocols: The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.Combined Modality Therapy: The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.Terminology as Topic: The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.Databases, Genetic: Databases devoted to knowledge about specific genes and gene products.ArchivesInternet: A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.Multigene Family: A set of genes descended by duplication and variation from some ancestral gene. Such genes may be clustered together on the same chromosome or dispersed on different chromosomes. Examples of multigene families include those that encode the hemoglobins, immunoglobulins, histocompatibility antigens, actins, tubulins, keratins, collagens, heat shock proteins, salivary glue proteins, chorion proteins, cuticle proteins, yolk proteins, and phaseolins, as well as histones, ribosomal RNA, and transfer RNA genes. The latter three are examples of reiterated genes, where hundreds of identical genes are present in a tandem array. (King & Stanfield, A Dictionary of Genetics, 4th ed)User-Computer Interface: The portion of an interactive computer program that issues messages to and receives commands from a user.Phylogeny: The relationships of groups of organisms as reflected by their genetic makeup.Sphingomyelins: A class of sphingolipids found largely in the brain and other nervous tissue. They contain phosphocholine or phosphoethanolamine as their polar head group so therefore are the only sphingolipids classified as PHOSPHOLIPIDS.Dens in Dente: Anomaly of the tooth, found chiefly in upper lateral incisors. It is characterized by invagination of the enamel at the incisal edge.Cyclohexanols: Monohydroxy derivatives of cyclohexanes that contain the general formula R-C6H11O. They have a camphorlike odor and are used in making soaps, insecticides, germicides, dry cleaning, and plasticizers.Sphingomyelin Phosphodiesterase: An enzyme that catalyzes the hydrolysis of sphingomyelin to ceramide (N-acylsphingosine) plus choline phosphate. A defect in this enzyme leads to NIEMANN-PICK DISEASE. EC 3.1.4.12.Absorption: The physical or physiological processes by which substances, tissue, cells, etc. take up or take in other substances or energy.Intestinal Absorption: Uptake of substances through the lining of the INTESTINES.Somatostatin: A 14-amino acid peptide named for its ability to inhibit pituitary GROWTH HORMONE release, also called somatotropin release-inhibiting factor. It is expressed in the central and peripheral nervous systems, the gut, and other organs. SRIF can also inhibit the release of THYROID-STIMULATING HORMONE; PROLACTIN; INSULIN; and GLUCAGON besides acting as a neurotransmitter and neuromodulator. In a number of species including humans, there is an additional form of somatostatin, SRIF-28 with a 14-amino acid extension at the N-terminal.Societies, Pharmaceutical: Societies whose membership is limited to pharmacists.Simbu virus: A species in the ORTHOBUNYAVIRUS genus of the family BUNYAVIRIDAE family. Previously a large group of serotypes, most are now considered separate species.Search Engine: Software used to locate data or information stored in machine-readable form locally or at a distance such as an INTERNET site.Methylurea Compounds: Urea compounds which are substituted with one or more methyl groups.Silk: A continuous protein fiber consisting primarily of FIBROINS. It is synthesized by a variety of INSECTS and ARACHNIDS.Spiders: Arthropods of the class ARACHNIDA, order Araneae. Except for mites and ticks, spiders constitute the largest order of arachnids, with approximately 37,000 species having been described. The majority of spiders are harmless, although some species can be regarded as moderately harmful since their bites can lead to quite severe local symptoms. (From Barnes, Invertebrate Zoology, 5th ed, p508; Smith, Insects and Other Arthropods of Medical Importance, 1973, pp424-430)Information Storage and Retrieval: Organized activities related to the storage, location, search, and retrieval of information.Acari: A large, subclass of arachnids comprising the MITES and TICKS, including parasites of plants, animals, and humans, as well as several important disease vectors.Publications: Copies of a work or document distributed to the public by sale, rental, lease, or lending. (From ALA Glossary of Library and Information Science, 1983, p181)Ochrobactrum: A genus of the family BRUCELLACEAE comprising obligately aerobic gram-negative rods with parallel sides and rounded ends.SwedenPublishing: "The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.Publication Bias: The influence of study results on the chances of publication and the tendency of investigators, reviewers, and editors to submit or accept manuscripts for publication based on the direction or strength of the study findings. Publication bias has an impact on the interpretation of clinical trials and meta-analyses. Bias can be minimized by insistence by editors on high-quality research, thorough literature reviews, acknowledgement of conflicts of interest, modification of peer review practices, etc.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.

Specific and sensitive assay for alkaline and neutral ceramidases involving C12-NBD-ceramide. (1/19)

A fluorescent analogue of ceramide, C12-NBD-ceramide, was found to be hydrolyzed much faster than 14C-labeled ceramide by alkaline ceramidase from Pseudomonas aeruginosa and neutral ceramidase from mouse liver, while this substrate was relatively resistant to acid ceramidase from plasma of the horseshoe crab. The radioactive substrate was used more preferentially by the acid ceramidase. It should be noted that C6-NBD-ceramide, which is usually used for ceramidase assays, was hardly hydrolyzed by any of the enzymes examined, compared to C12-NBD-ceramide. For the alkaline and neutral enzymes, the Vmax and k (Vmax/Km) with C12-NBD-ceramide were much higher than those with 14C-ceramide. In contrast, for the acid enzyme these parameters with C12-NBD-ceramide were less than half those with the radioisotope-labeled substrate. It is noteworthy that the labeling of ceramide with NBD did not itself reduce the Km of the alkaline enzyme, but did that of the neutral enzyme. It was also found that C12-NBD-ceramide was preferentially hydrolyzed by the alkaline and neutral enzymes, but not the acid one, in several mammalian cell lines. This study clearly shows that the attachment of NBD, but not dansyl, increases the susceptibility of ceramide to alkaline and neutral enzyme, and decreases that to acid enzymes. Thus the use of this substrate provides a specific and sensitive assay for alkaline and neutral ceramidases.  (+info)

Molecular cloning, sequencing, and expression of the gene encoding alkaline ceramidase from Pseudomonas aeruginosa. Cloning of a ceramidase homologue from Mycobacterium tuberculosis. (2/19)

We previously reported the purification and characterization of a novel type of alkaline ceramidase from Pseudomonas aeruginosa strain AN17 (Okino, N., Tani, M., Imayama, S., and Ito, M. (1998) J. Biol. Chem. 273, 14368-14373). Here, we report the molecular cloning, sequencing, and expression of the gene encoding the ceramidase of this strain. Specific oligonucleotide primers were synthesized using the peptide sequences of the purified ceramidase obtained by digestion with lysylendopeptidase and used for polymerase chain reaction. DNA fragments thus amplified were used as probes to clone the gene encoding the ceramidase from a genomic library of strain AN17. The open reading frame of 2,010 nucleotides encoded a polypeptide of 670 amino acids including a signal sequence of 24 residues, 64 residues of which matched the amino acid sequence determined for the purified enzyme. The molecular weight of the mature enzyme was estimated to be 70,767 from the deduced amino acid sequence. Expression of the ceramidase gene in Escherichia coli, resulted in production of a soluble enzyme with the identical N-terminal amino acid sequence. Recombinant ceramidase was purified to homogeneity from the lysate of E. coli cells and confirmed to be identical to the Pseudomonas enzyme in its specificity and other enzymatic properties. No significant sequence similarities were found in other known functional proteins including human acid ceramidase. However, we found a sequence homologous to the ceramidase in hypothetical proteins encoded in Mycobacterium tuberculosis, Dictyostelium discoideum, and Arabidopsis thaliana. The homologue of the ceramidase gene was thus cloned from an M. tuberculosis cosmid and expressed in E. coli, and the gene was demonstrated to encode an alkaline ceramidase. This is the first report for the cloning of an alkaline ceramidase.  (+info)

Purification and characterization of a neutral ceramidase from mouse liver. A single protein catalyzes the reversible reaction in which ceramide is both hydrolyzed and synthesized. (3/19)

We report here a novel ceramidase that was purified more than 150, 000-fold from the membrane fraction of mouse liver. The enzyme was a monomeric polypeptide having a molecular mass of 94 kDa and was highly glycosylated with N-glycans. The amino acid sequence of a fragment obtained from the purified enzyme was homologous to those deduced from the genes encoding an alkaline ceramidase of Pseudomonas aeruginosa and a hypotheical protein of the slime mold Dictyostelium discoideum. However, no significant sequence similarities were found in other known functional proteins including acid ceramidases of humans and mice. The enzyme hydrolyzed various N-acylsphingosines but not galactosylceramide, sulfatide, GM1a, or sphingomyelin. The enzyme exhibited the highest activity around pH 7.5 and was thus identified as a type of neutral ceramidase. The apparent K(m) and V(max) values for C12-4-nitrobenzo-2-oxa-1, 3-diazole-ceramide and C16-(14)C-ceramide were 22.3 microM and 29.1 micromol/min/mg and 72.4 microM and 3.6 micromol/min/mg, respectively. This study also clearly demonstrated that the purified 94-kDa ceramidase catalyzed the condensation of fatty acid to sphingosine to generate ceramide, but did not catalyze acyl-CoA-dependent acyl-transfer reaction.  (+info)

Cloning and characterization of a novel human alkaline ceramidase. A mammalian enzyme that hydrolyzes phytoceramide. (4/19)

Ceramidases are enzymes involved in regulating cellular levels of ceramides, sphingoid bases, and their phosphates. Based on sequence homology to the yeast alkaline ceramidases YPC1p (Mao, C., Xu, R., Bielawska, A., and Obeid, L. M. (2000) J. Biol. Chem. 275, 6876--6884) and YDC1p (Mao, C., Xu, R., Bielawska, A., Szulc, Z. M., and Obeid, L. M. (2000) J. Biol Chem. 275, 31369--31378), we report the identification and cloning of a cDNA encoding for a novel human alkaline ceramidase (aPHC) that hydrolyzes phytoceramide selectively. Northern blot analysis showed that aPHC was ubiquitously expressed, with the highest expression in placenta. Green fluorescent protein tagging showed that it was localized in both the Golgi apparatus and endoplasmic reticulum. Overexpression of aPHC in mammalian cells elevated in vitro ceramidase activity toward N-4-nitrobenz-2-oxa-1,3-diazole-C(12)-phytoceramide. Its expression in a yeast mutant strain devoid of any ceramidase activity restored the ceramidase activity and caused an increase in the hydrolysis of phytoceramide in yeast cells, thus leading to the decreased biosynthesis of sphingolipids. These data collectively suggest that, similar to the yeast phytoceramidase YPC1p, aPHC has phytoceramidase activity both in vitro and in cells; hence, it is a functional homolog of the yeast phytoceramidase YPC1p. However, in contrast to YPC1p, aPHC exhibited no reverse activity of ceramidase either in vitro or in cells. Biochemical characterization showed that aPHC had a pH optimum of 9.5, was activated by Ca(2+), but was inhibited by Zn(2+) and sphingosine. Substrate specificity showed that aPHC hydrolyzed phytoceramide preferentially. Together, these data demonstrate that aPHC is a novel human alkaline phytoceramidase, the first mammalian alkaline ceramidase to be identified as being specific for the hydrolysis of phytoceramide.  (+info)

Cloning and characterization of a mouse endoplasmic reticulum alkaline ceramidase: an enzyme that preferentially regulates metabolism of very long chain ceramides. (5/19)

Ceramidases deacylate ceramides, important intermediates in the metabolic pathway of sphingolipids. In this study, we report the cloning and characterization of a novel mouse alkaline ceramidase (maCER1) with a highly restricted substrate specificity. maCER1 consists of 287 amino acids, and it has a 28 and 32% identity to the Saccharomyces alkaline ceramidases (YPC1p and YDC1p) and the human alkaline phytoceramidase, respectively. Reverse transcriptase-PCR analysis demonstrated that maCER1 was predominantly expressed in skin. maCER1 was localized to the endoplasmic reticulum as revealed by immunocytochemistry. In vitro biochemical characterization determined that maCER1 hydrolyzed D-erythro-ceramide exclusively but not D-erythro-dihydroceramide or D-ribo-phytoceramide. Similar to other alkaline ceramidases, maCER1 had an alkaline pH optimum of 8.0, and it was activated by Ca2+ but inhibited by Zn2+,Cu2+, and Mn2+. maCER1 was also inhibited by sphingosine, one of its products. Metabolic labeling studies showed that overexpression of maCER1 caused a decrease in the incorporation of radiolabeled dihydrosphingosine into ceramide and complex sphingolipids but led to a concomitant increase in sphingosine-1-P (S1P) in HeLa cells. Mass measurement showed that overexpression of maCER1 selectively lowered the cellular levels of D-erythro-C24:1-ceramide, but not other ceramide species and caused an increase in the levels of S1P. Taken together, these data suggest that maCER1 is a novel alkaline ceramidase with a stringent substrate specificity and that maCER1 is selectively expressed in skin and may have a role in regulating the levels of bioactive lipids ceramide and S1P, as well as complex sphingolipids.  (+info)

Golgi alkaline ceramidase regulates cell proliferation and survival by controlling levels of sphingosine and S1P. (6/19)

Sphingosine-1-phosphate (S1P), a sphingolipid metabolite, promotes cell proliferation and survival whereas its precursor, sphingosine, has the opposite effects. However, much remains unknown about their regulation. Here we identify a novel human ceramidase (haCER2) that regulates the levels of both sphingosine and S1P by controlling the hydrolysis of ceramides. haCER2 is localized to the Golgi complex and is highly expressed in the placenta. High ectopic expression of haCER2 caused fragmentation of the Golgi complex and growth arrest in HeLa cells due to sphingosine accumulation. Low ectopic expression of haCER2 increased S1P without sphingosine accumulation, promoting cell proliferation in serum-free medium. This proliferative effect was suppressed by dimethylsphingosine, an inhibitor of the S1P formation, or by the RNA interference (RNAi) -mediated inhibition of S1P(1,) a G-protein-coupled receptor for S1P. The RNAi-mediated down-regulation of haCER2 enhanced the serum deprivation-induced growth arrest and apoptosis of HeLa cells, which was inhibited by addition of exogenous S1P. Serum deprivation up-regulated both haCER2 mRNA and activity in HeLa cells. haCER2 mRNA is also up-regulated in some tumors. Taken together, these results suggest that haCER2 is important for the generation of S1P and S1P-mediated cell proliferation and survival, but that its overexpression may cause cell growth arrest due to an accumulation of sphingosine.  (+info)

Upregulation of the human alkaline ceramidase 1 and acid ceramidase mediates calcium-induced differentiation of epidermal keratinocytes. (7/19)

Extracellular calcium (Ca2+(o)) potently induces the growth arrest and differentiation of human epidermal keratinocytes (HEKs). We report that Ca2+(o) markedly upregulates the human alkaline ceramidase 1 (haCER1) in HEKs; and its upregulation mediates the Ca2+(o)-induced growth arrest and differentiation of HEKs. haCER1 is the human ortholog of mouse alkaline ceramidase 1 that we previously identified. haCER1 catalyzed the hydrolysis of very long-chain ceramides to generate sphingosine (SPH). This in vitro activity required Ca2+. Ectopic expression of haCER1 in HEKs decreased the levels of D-e-C(24:1)-ceramide and D-e-C(24:0)-ceramide but elevated the levels of both SPH and its phosphate (S1P), whereas RNA interference-mediated knockdown of haCER1 caused the opposite effects on the levels of these sphingolipids in HEKs. Similar to haCER1 overexpression, Ca2+(o) increased the levels of SPH and S1P, and this was attenuated by haCER1 knockdown. haCER1 knockdown also inhibited the Ca2+(o)-induced growth arrest of HEKs and the Ca2+(o)-induced expression of keratin 1 and involucrin in HEKs. In addition, the acid ceramidase (AC) was also upregulated by Ca2+(o); and its knockdown attenuated the Ca2+(o)-induced expression of keratin 1 and involucrin in HEKs. These results strongly suggest that upregulation of haCER1 and AC mediates the Ca2+(o)-induced growth arrest and differentiation of HEKs by generating SPH and S1P.  (+info)

Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and sphingosine-1-phosphate. (8/19)

 (+info)

K00654 SPT; serine palmitoyltransferase [EC:2.3.1.50] K00654 SPT; serine palmitoyltransferase [EC:2.3.1.50] K00654 SPT; serine palmitoyltransferase [EC:2.3.1.50] K04708 E1.1.1.102; 3-dehydrosphinganine reductase [EC:1.1.1.102] K04710 CERS; ceramide synthetase [EC:2.3.1.24] K04710 CERS; ceramide synthetase [EC:2.3.1.24] K04710 CERS; ceramide synthetase [EC:2.3.1.24] K04710 CERS; ceramide synthetase [EC:2.3.1.24] K04710 CERS; ceramide synthetase [EC:2.3.1.24] K04710 CERS; ceramide synthetase [EC:2.3.1.24] K12348 ASAH1; acid ceramidase [EC:3.5.1.23] K12349 ASAH2; neutral ceramidase [EC:3.5.1.23] K01441 ACER1_2; alkaline ceramidase [EC:3.5.1.23] K01441 ACER1_2; alkaline ceramidase [EC:3.5.1.23] K04711 ACER3; dihydroceramidase [EC:3.5.1.-] K04712 DEGS; sphingolipid 4-desaturase/C4-monooxygenase [EC:1.14.19.17 1.14.18.5] K04712 DEGS; sphingolipid 4-desaturase/C4-monooxygenase [EC:1.14.19.17 1.14.18.5] K04714 SGMS; shingomyelin synthase [EC:2.7.8.27] K04714 SGMS; shingomyelin synthase [EC:2.7.8.27] ...
The epidermis is the outermost layer of skin that acts as a barrier to protect the body from the external environment and to control water and heat loss. This barrier function is established through the multistage differentiation of keratinocytes and the presence of bioactive sphingolipids such as c …
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Erika Espinoza of Free Hoop is sharing this useful little tutorial for all of our Spanish-speaking hoopers out there who want to give it a go and make their own hula hoop! Her recommendations for materials are mostly stuff you can get at your local hardware store and you need no more than your kitchen and some space to make it all happen. So go for it and try making your own hula! Erika lives Monterrey, Nuevo Leon, Mexico.. Erika Espinoza de Free Hoop nos comparte este pequeño tutorial, super útil para todos nuestros hoopers de habla hispana que quisieran intentar hacer sus propios aros hula hula. Sus recomendaciones para los materiales son en su mayoría cosas que puedes conseguir en la ferretería o tienda de materiales más cercana. No necesitas más que tu cocina y un espacio para hacer que todo suceda. Así que, inténtalo y estamos seguros que te sentirás [email protected] de hacer tu propia hula. Erika vive Monterrey, Nuevo León, México.. ...
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Hoy por fin despues de muchos dias, me puse a hacer tarjetas para mi tienda, la mayoria fueron hechas con colores alucivos a la primavera que ya esta a la vuelta de la esquina, aunque aqui en pa. aun tenemos 2 pies de nieve y esta muy frio pero bueno, llegara cuando menos nos lo esperemos. Por cierto estoy muy emocionada utlizando mi nueva herramienta de calor con la que puedo hacer el relieve de los sellos... me encanta ...
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2009/3/6 Marcelo Guzmán ,marcegl91 at gmail.com,: ,, Evitar el top-posting está entre las sugerencias, no entre las reglas. , , De hecho, no. Se obliga al user a no hacer top-posting. Ojo, eh!. Yo estoy de acuerdo con NO hacer top posting..., pero es falso que es una sugerencia, son las reglas de la lista, y como ellas mismas, deben ser respetadas. Marcelo: Acá tenés las reglas y las sugerencias. Te recomiendo que las leas: https://wiki.ubuntu.com/ArgentinaTeam/EtiquetaML Idem para el compañero Hugo Valencia. No seamos más estrictos que la propia etiqueta. Querámosnos. Saludos Moski ...
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Publications Is it a Cold or Flu or COVID-19? ¿Es un Resfriado o Influenza o COVID-19? COVID-19 What if Ive Been Exposed ¿Qué pasa si he estado expuesto? (en Español) Social Distancing Distanciamiento Social (en Español) Social Distancing: What does it mean? Distanciamiento social: ¿qué significa? Face Coverings Dos and Donts Cubrirse la cara Qué hacer y qué no hacer
Dark_Ryoga : Encontre por fin tonos polifonicos para hacer con tu celular ! ya ke no me los puedo bajar de internet, me los puedo hacer son... : Offtopic
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Pagina dedicada a los peque os artistas. Que les gusta escribir, dibujar, hacer webs, videos, fanarts, fanfics... Aqu subir n sus trabajos online directamente y tendr n su propia galer a. a qu esperas?
Pagina dedicada a los peque os artistas. Que les gusta escribir, dibujar, hacer webs, videos, fanarts, fanfics... Aqu subir n sus trabajos online directamente y tendr n su propia galer a. a qu esperas?
Alguien recibio una respuesta parecida en hacer If its completely as sole provider however in understanding it still allowed while CVS and minimize. As a...
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... Las frutas con menos calorias. Partes del aparato fonador Cuerdas vocales son musculos las, que hacer cuando un nino convulsiona por fiebre alta.
Directo USA entrevista al Senador estatal de Califonia Ben Allen sobre su propuesta de ley para hacer obligar la vacunación en California
... - Request PDF on ResearchGate | Esteatohepatitis alcohólica y no alcohólica: ¿ quiénes son los pacientes y qué podemos hacer por ellos? | The most common.
Doppt Zykkler es un Net label creado en 2010 por y para músicos donde se intenta reflejar nuestras inquietudes musicales y hacer partícipe al público en general ...
Bueno para quienes quieran contactarme vía e-mail para hacer pedidos, por si se rompe algún enlace, o cualquier otro motivo. ...
Bueno para quienes quieran contactarme vía e-mail para hacer pedidos, por si se rompe algún enlace, o cualquier otro motivo. ...
Equipo de Asistencia de Servicios Generales (GSA) del Centro de Cáncer de UNM Como paciente nuevo, es muy probable que tenga muchas preguntas acerca de sus cuidados y sobre qué hacer si se presentan ciertas situaciones. A continuación, aparecen algunas de las preguntas más frecuentes. Si tiene preguntas adicionales, no dude en dirigirse a su Asesor …
De gusto a uno de sus allegados ofreciéndole esta tarjeta regalo. Usted puede dársela en mano o hacer que se la envíen directamente. See for more details (Instructions in English : voir la versio
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Donde puedo comprar Un estimulante hormonal de iforce nutrition barato ZMA para aumentar la testosterona de forma rápida y hacer crecer los músculos muy sano
De gusto a uno de sus allegados ofreciéndole esta tarjeta regalo. Usted puede dársela en mano o hacer que se la envíen directamente. See for more details (Instructions in English : voir la versio
Cihangir Kaymaz, Nur en Kele , Nihal zdemir, brahim Halil Tanbo a, Hacer C. Demircan, Mehmet M. Can, Fatih Koca, brahim Ak n zgi, Alper zkan, Muhsin T rkmen, Cevat K rma, Ali M. ...
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Una vez descargado el curso o capítulo, ir a la carpeta donde se descargó y hacer clic sobre el archivo para instalarlo en su ordenador. Cuando acabe la instalación aparecerá en el menú Inicio un grupo de programas llamado Curso de ViaFutura. Haga clic en cualquiera de los capítulos para poner en funcionamiento el mismo ...
Music video by Sethler performing Qué Vas a Hacer. (P) 2013 The copyright in this sound recording is owned by Hugo Martín Cuervo under exclusive licence to EMI Music Spain, S.L.. Watch it on Contactmusic.com.
Cuando una persona es adolescente comienza a estar más consciente de lo que piensan otras personas. Parece haber algo "correcto" que ponerse, o decir, o hacer. También parecen estar las cosas que no se deben hacer; cosas que podrían ser vergonzosas, o que lo harán perder puntos con los amigos.. La idea de que las personas puedan estar prestando atención particular a lo que hacen, pone a muchos niños ansiosos; algunos están tan ansiosos que desarrollan algo que se llama trastorno de ansiedad social. Es cuando una persona se preocupa tanto acerca de lo que le parece a otras personas que deja de hacer las cosas que necesita (y desea hacer) por el miedo a avergonzarse a sí mismo.. La mayoría de las personas con el trastorno comienza a notar esta ansiedad cuando están en edades entre 8 y 15 años. Durante un tiempo, los niños usualmente son capaces de ocultarlo. Sus padres y maestros podrían no notar que haya algo malo, especialmente debido a que los niños con frecuencia se sienten ...
Empezé a elegir lo que me gustaba, a hacer las cosas que me apetecían y no lo que debería de hacer.. Y es en estos cambios en los que estoy interesado, en que las personas elijan lo que les divierte y les hace vivos.. Era un estudiante normal a pesar de que no entendía mucho el por qué estudiar tantas cosas y tener unos horarios repetitivos y estructuras. Un poco aburrido.. Así que entre esa rebeldia y curiosidad para descubrir otras formas de vivir, me di cuenta que quería dedicar mi vida a hacer lo que me guste.. Y veo que eso crea un mundo mejor para mi y para otras personas, cuando uno elije lo que le funciona, se respeta y así puede respetar las elecciones de los otros, con lo cual se crea más facilidad para el mundo y una realidad más grandiosa.. Y encontrar Access ha sido un regalo immenso para que esto sea posible. Para tener más de mí. Conocer mucho más de mi y abrirme a recibir y crear mucho más en esta vida en este planeta. Agradezco a Access Consciuosness y sus ...
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In some countries, you might find that the Women on Web website is censored. Here you can read about several ways you… Read more » ...
La clave para perder peso es hacer cambios peque os todos los d as. Esto ayuda a establecer h bitos saludables y duraderos. Las dietas que prometen ayudarte a perder peso r pido no son saludables y pueden hacer que subas de peso ...
Childrens Health de Dallas dio a conocer un protocolo para padres de familia que sospechen que sus hijos hayan contraído el virus covid-19. Las...
Answer YES (Si) or NO (Circle/Circule). Yes or No: I have to struggle to finish jobs (Tengo que luchar para terminar los trabajos). Yes or No: I feel a strong need to sleep during the day (Me siento una fuerte necesidad de dormir durante el día). Yes or No: I often feel lonely even when I am with other people (Me siento solo aunque este con otras personas). Yes or No: I have to read things several times before they sink in (Leo las cosas varias veces antes de memorizar las). Yes or No: Its difficult for me to make friends (Es difícil para mí hacer amigos). Yes or No: It takes a lot of effort for me to do simple tasks (Me toma mucho esfuerzo para hacer labores simples). Yes or No: I have difficulty controlling my emotions (Tengo dificultad para controlar mis emociones). Yes or No: I often lose track of what I want to say (Muchas veces pierdo la noción de lo que quiero decir). Yes or No: I lack confidence (No tengo confianza en mí). Yes or No: I have to push myself to do things (Tengo que ...
Ingredientes. 1 litro de leche entera. 1 1/4 taza de azùcar. 1 cucharadita de vainilla. 4 huevos grandes. pizca de sal. 150 grs. de Dulce de Leche. En muchos paìse no hay Dulce de Leche y para los que no lo sepan preparar encontrè una receta muy buena en un Blog de Lauriels kitchen que dice asì:. " Para hacer dulce de leche en casa retire primero las etique. tas de los tarros de leche condensada azucarada. (se pueden hacer dos o tres por vez, y se guardan....si es que pueden) Coloque los tarros sin abrir en una olla grande y coloque suficeinte agua para cubrirlos. 1 o 2 pulgadas. Pongalos a hervir con agua hasta que hiervan a fuego fuerte, entonces baje el calor a fuego medio, tàpelos y dèjelos cocer por 2 horas aprox., agregue màs agua si es neceario y tenga cuidado que nunca queden sin agua los tarros y que estèn completamente cubiertos. Despues cuando esten listos dèjelos enfriar a temperatura ambiente (o se pueden colocar en agua frìa) pero hay que dejarlos enfriar bien antes de ...
... O mala gledaj kom si srce dala taj ti nikad nece reci hvala. Slusaj rasta coby mala. Baby dime qué tengo que hacer he said mi nena tú ere. Tekst pjesme jelena karleusa mala. Mala tekst zana. Mala voli audi mala voli bmw mala voli dolare mala voli evre penje se na stolove voli separe nemoj biti siguran da mala voli tebe x2 ona mi u klubu deluje baš tako da ni jednu drugu nikad ne bih tako naručila je turu popiće je lako. Da li ona zna ma da li ona zna ma da li ona zna koliko sam starija da bi bila kao ja trebace jos ovoliko do tada cao cao mala ti si niko. 2x ta mala treba jos da uci mala jos si mlada. Ma da li ona zna ma da li ona zna ma da li ona zna da li zna ko sam ja ma pusti tu malu kuci neka ceka sta ti to treba kad znas da sam broj jedan. Anuel anuel real hasta la muerte baby uah qué tengo que hacer pa que tú sea mi mujer. Lyrics tekst pjesme dodaj ili ispravi tekst. Ti sa takvim grudima ti sa takvim ocima mogla si da imas svet ceo svet pod nogama. ...
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Acer Travelmate 290 / 292Lmi freeze on reboot HI All, I own an acer 292Lmi (which is basically a 290 with a little - Acer TravelMate 290 Notebook question
Alkaline ceramidase 3 also known as ACER3 is a ceramidase enzyme which in humans is encoded by the ACER3 gene. GRCh38: Ensembl ... "Cloning and characterization of a novel human alkaline ceramidase. A mammalian enzyme that hydrolyzes phytoceramide". J. Biol. ... Mao C, Obeid LM (September 2008). "Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and ...
Alkaline ceramidase 2 also known as ACER2 is a ceramidase enzyme which in humans is encoded by the ACER2 gene. The ACER2/ ... Sun W, Hu W, Xu R, Jin J, Szulc ZM, Zhang G, Galadari SH, Obeid LM, Mao C (February 2009). "Alkaline ceramidase 2 regulates ... 2006). "Golgi alkaline ceramidase regulates cell proliferation and survival by controlling levels of sphingosine and S1P". ... "Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and sphingosine-1-phosphate". Biochim. Biophys ...
"Human meconium contains significant amounts of alkaline sphingomyelinase, neutral ceramidase, and sphingolipid metabolites". ... and named alkaline sphingomyelinase (alk-SMase), as the optimal pH of the enzyme was 9.0 and its main substrate is ... 2005). "Cloning of alkaline sphingomyelinase from rat intestinal mucosa and adjusting of the hypothetical protein XP_221184 in ... Andersson D, Kotarsky K, Wu J, Agace W, Duan RD (July 2009). "Expression of alkaline sphingomyelinase in yeast cells and anti- ...
2006). "Golgi alkaline ceramidase regulates cell proliferation and survival by controlling levels of sphingosine and S1P". ... A novel but highly conserved gene family of neutral/alkaline ceramidases". J. Biol. Chem. 275 (15): 11229-34. doi:10.1074/jbc. ... Neutral ceramidase is an enzyme that in humans is encoded by the ASAH2 gene. GRCh38: Ensembl release 89: ENSG00000188611 - ... 2004). "Neutral ceramidase gene: role in regulating ceramide-induced apoptosis". Gene. 315: 113-22. doi:10.1016/S0378-1119(03) ...
2006). "Golgi alkaline ceramidase regulates cell proliferation and survival by controlling levels of sphingosine and S1P". ... Sphingosine (Sph) is formed by the action of ceramidase (CDase) enzymes on ceramide in the lysosome. Sph can also be formed in ... The low levels of Sph and their increase in response to stimulation of cells, primarily by activation of ceramidase by growth- ... Ceramide can also be broken down by enzymes called ceramidases, leading to the formation of sphingosine, Moreover, a phosphate ...
Alkaline ceramidase 1 also known as ACER1 is a ceramidase enzyme which in humans is encoded by the ACER1 gene. ACER1 mediates ... "Upregulation of the human alkaline ceramidase 1 and acid ceramidase mediates calcium-induced differentiation of epidermal ... "Cloning and characterization of a mouse endoplasmic reticulum alkaline ceramidase: an enzyme that preferentially regulates ... Ito M, Okino N, Tani M, Mitsutake S, Mori K (Mar 2002). "[Molecular evolution of neutral ceramidase: signalling molecule and ...
... cell survival neutral ceramidase (ASAH2, ASAH2B, ASAH2C) - protective against inflammatory cytokines alkaline ceramidase 1 ( ... Presently, 7 human ceramidases encoded by 7 distinct genes have been cloned: acid ceramidase (ASAH1) - ... mediating cell differentiation by controlling the generation of SPH and S1P alkaline ceramidase 2 (ACER2) - important for cell ... Ceramidase at the US National Library of Medicine Medical Subject Headings (MeSH) EC 3.5.1.23 Molecular and Cellular Biology ...
Aspergillus alkaline proteinase. Now EC 3.4.21.63, oryzin EC 3.4.21.16: Deleted entry: Alternaria serine proteinase EC 3.4. ... ceramidase EC 3.5.1.24: choloylglycine hydrolase EC 3.5.1.25: N-acetylglucosamine-6-phosphate deacetylase EC 3.5.1.26: N4-(beta ... alkaline phosphatase EC 3.1.3.2: acid phosphatase EC 3.1.3.3: phosphoserine phosphatase EC 3.1.3.4: phosphatidate phosphatase ...
Alkaline ceramidase YPC1Add BLAST. 316. Proteomic databases. PaxDb, a database of protein abundance averages across all three ... Alkaline ceramidase YPC1 (EC:3.5.1.-*Search proteins in UniProtKB for this EC number. ... "Characterization of yeast mutants lacking alkaline ceramidases YPC1 and YDC1.". Voynova N.S., Mallela S.K., Vazquez H.M., ... Belongs to the alkaline ceramidase family.Curated. Keywords - Domaini. Transmembrane, Transmembrane helix. Phylogenomic ...
... J Pathol. 2016 ... Here we reveal the essential role of alkaline ceramidase 1 (Acer1) in the skin. Acer1-deficient (Acer1(-/-) ) mice showed ... the levels of which are tightly regulated by a balance of ceramide synthase and ceramidase activities. ...
Mouse Alkaline ceramidase 1 (ACER1) ELISA Kit-NP_597999.1 (MBS7235867) product datasheet at MyBioSource, ELISA Kits ... alkaline ceramidase 1; alkCDase 1; alkaline CDase 1; acylsphingosine deacylase 3; N-acylsphingosine amidohydrolase 3; N- ... ACER1 elisa kit :: Mouse Alkaline ceramidase 1 (ACER1) ELISA Kit. Catalog #. MBS7235867 .mycenter { display: block; margin-left ... Belongs to the alkaline ceramidase family.. Protein type: Hydrolase; Lipid Metabolism - sphingolipid; EC 3.5.1.23; Endoplasmic ...
ACER2; alkaline ceramidase 2; ASAH3L, N acylsphingosine amidohydrolase 3 like; FLJ41587; haCER2; alkCDase 2; alkaline CDase 2; ... The ceramidase ACER2 hydrolyzes very long chain ceramides to generate;sphingosine (Xu et al., 2006 (PubMed 16940153)). ...
alkaline ceramidase 1 MGI:2181962 .yui-skin-sam .yui-dt th{ background:url(http://www.informatics.jax.org/webshare/images/cre/ ...
Expression of Intestinal and Lung Alkaline Sphingomyelinase and Neutral Ceramidase in Cystic Fibrosis F508del Transgenic Mice. ...
ceramidase;. acylsphingosine deacylase;. glycosphingolipid ceramide deacylase. Class. Hydrolases;. Acting on carbon-nitrogen ...
Several canonical genes encoding ceramide synthase (encoded by PcLAG1 and PcLAF1), alkaline ceramidase (PcYXC1) and ...
Cloning and characterization of a mouse endoplasmic reticulum alkaline ceramidase: an enzyme that preferentially regulates ... Cloning and characterization of a novel human alkaline ceramidase. A mammalian enzyme that hydrolyzes phytoceramide. ...
340485 ACER2; alkaline ceramidase 2 125981 ACER1; alkaline ceramidase 1 55331 ACER3; alkaline ceramidase 3 8560 DEGS1; delta 4- ... neutral ceramidase [EC:3.5.1.23] K01441 ACER1_2; alkaline ceramidase [EC:3.5.1.23] K01441 ACER1_2; alkaline ceramidase [EC:3.5. ... neutral ceramidase [EC:3.5.1.23] K01441 ACER1_2; alkaline ceramidase [EC:3.5.1.23] K01441 ACER1_2; alkaline ceramidase [EC:3.5. ... 340485 ACER2; alkaline ceramidase 2 125981 ACER1; alkaline ceramidase 1 8717 TRADD; TNFRSF1A associated via death domain 7186 ...
Alkaline ceramidase 2 (Acer2) is a type of ceramidases, which are key enzymes of the degradation of intracellular ceramide and ... Acer2 (alkaline ceramidase 2) regulates the hydrolysis of ceramides. Slc38a2 (solute carrier family 38 member 2) is a sodium- ... P. W. Wertz and D. T. Downing, "Ceramidase activity in porcine epidermis," FEBS Letters, vol. 268, no. 1, pp. 110-112, 1990. ...
Alkaline Ceramidase 2 Pseudogene 3 * AC017081.1 5 External Ids for ACER2P1 Gene. *HGNC: 54674 ...
Alkaline ceramidase 1. NM_133492. Gene Info. ACER2. Alkaline ceramidase 2. NM_001010887. Gene Info. ... Alkaline phosphatase, liver/bone/kidney. NM_000478. NM_001127501. NM_001177520. Gene Info. ...
Alkaline ceramidase 2. NM_139306. Gene Info. Acer2. Alkaline ceramidase 2. AK046888. Gene Info. ...
Ceramidase and ceramide synthesis in human kidney and cerebellum. Description of a new alkaline ceramidase. Biochim Biophys ... Effect of hypoxia on acid ceramidase (AC) RNA levels in Ewings sarcoma family of tumors cell lines and of AC inhibitor on ... The metabolic pathway for ceramides includes deacylation by alkaline, neutral, and AC (43 , 82) to generate sphingosine, which ... Ferlinz K, Kopal G, Bernardo K, et al Human acid ceramidase: processing, glycosylation, and lysosomal targeting. J Biol Chem, ...
Alkaline ceramidase 3 also known as ACER3 is a ceramidase enzyme which in humans is encoded by the ACER3 gene. GRCh38: Ensembl ... "Cloning and characterization of a novel human alkaline ceramidase. A mammalian enzyme that hydrolyzes phytoceramide". J. Biol. ... Mao C, Obeid LM (September 2008). "Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and ...
Targeting alkaline ceramidase 3 alleviates the severity of nonalcoholic steatohepatitis by reducing oxidative stress. ...
Targeting alkaline ceramidase 3 alleviates the severity of nonalcoholic steatohepatitis by reducing oxidative stress. ...
Alkaline ceramidase 2 also known as ACER2 is a ceramidase enzyme which in humans is encoded by the ACER2 gene. The ACER2/ ... Sun W, Hu W, Xu R, Jin J, Szulc ZM, Zhang G, Galadari SH, Obeid LM, Mao C (February 2009). "Alkaline ceramidase 2 regulates ... 2006). "Golgi alkaline ceramidase regulates cell proliferation and survival by controlling levels of sphingosine and S1P". ... "Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and sphingosine-1-phosphate". Biochim. Biophys ...
Alkaline ceramidase 2 regulates beta1 integrin maturation and cell adhesion. Sun W, Hu W, Xu R, Jin J, Szulc ZM, Zhang G, ... Correction: Alkaline Ceramidase 3 Deficiency Results in Purkinje Cell Degeneration and Cerebellar Ataxia Due to Dyshomeostasis ... Correction: Alkaline Ceramidase 3 Deficiency Results in Purkinje Cell Degeneration and Cerebellar Ataxia Due to Dyshomeostasis ... Alkaline Ceramidase 3 Deficiency Results in Purkinje Cell Degeneration and Cerebellar Ataxia Due to Dyshomeostasis of ...
alkaline ceramidase 2. protein-coding. APOA2. apolipoprotein A2. protein-coding. AADAT. aminoadipate aminotransferase. protein- ...
alkaline ceramidase 2 Assay Type: Probe Assay Design: exonic Application: Gene Expression Unique Assay ID: qHsaCEP0054485 FAM ... alkaline ceramidase 2 Assay Type: EvaGreen Application: Gene Expression Unique Assay ID: dHsaEG5011581 Info: EG; Same primer ... alkaline ceramidase 2 Assay Type: EvaGreen Application: Gene Expression Unique Assay ID: dHsaEG5024518 Info: EG; Same primer ... alkaline ceramidase 2 Assay Type: Probe Application: Gene Expression Unique Assay ID: dHsaCPE5041472 Info: FAM; Same primer ...
Alkaline ceramidase 2. Aliases:. 2410116I05Rik, Asah3l, CRG-L1, maCER2. RefSeq:. NC_000070.6 NT_187032.1. ...
Alkaline ceramidases (ACER). *Alkylation repair homologs (ALKB). *Aminoacyl tRNA synthetases *Aminoacyl tRNA synthetases, Class ...
Nonlysosomal ceramidase Ceramidase (CDase) is an enzyme that hydrolyzes the N-acyl linkage between a fatty acid and a sphingoid ... and expression of the gene encoding alkaline ceramidase from Pseudomonas aeruginosa. Cloning of a ceramidase homologue from ... A novel but highly conserved gene family of neutral/alkaline ceramidases. J Biol Chem. 2000b;275:11229-34.CrossRefPubMedGoogle ... Tani M., Ito M. (2018) Neutral Ceramidase. In: Choi S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. * .RIS Papers ...
  • MBS7235867 is a ready-to-use microwell, strip plate Competitive (Quantitative) ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Alkaline ceramidase 1 (ACER1) ELISA Kit target analytes in biological samples. (mybiosource.com)
  • Correction: Alkaline Ceramidase 3 Deficiency Results in Purkinje Cell Degeneration and Cerebellar Ataxia Due to Dyshomeostasis of Sphingolipids in the Brain. (nih.gov)
  • Several canonical genes encoding ceramide synthase (encoded by PcLAG1 and PcLAF1), alkaline ceramidase (PcYXC1) and sphingolipid C-4-hydroxylase(PcSYR2), as well as structural genes for dihydroceramide Δ(4)-desaturase (PcDES1) and sphingolipid Δ(8)-desaturase (PcSLD1) were identified, indicating that P. ciferrii would be capable of synthesizing desaturated sphingoid bases, a property not ubiquitously found in yeasts. (nih.gov)