Alkaline Ceramidase: A ceramidase subtype that is active at alkaline pH. It is found at high levels within the SMALL INTESTINE.Ceramidases: Amidohydrolases that are specific for the cleavage of the N-acyl linkage of CERAMIDES. Ceramidases are classified as acidic, neutral or basic according to the optimal pH with which they function.Acid Ceramidase: A ceramidase subtype that is active at acid pH. It plays an important role in sphingolipid degradation by catalyzing the lysosomal hydrolysis of ceramide to sphingosine and free fatty acid. Inherited deficiency of acid ceramidase activity results in FARBER LIPOGRANULOMATOSIS.Neutral Ceramidase: A ceramidase subtype that is active at neutral pH. It is found at high levels within the SMALL INTESTINE and in the BRAIN.Galactosylgalactosylglucosylceramidase: An enzyme that catalyzes the hydrolysis of a ceramidetrihexoside to a ceramidedihexoside plus galactose.AmidohydrolasesCeramides: Members of the class of neutral glycosphingolipids. They are the basic units of SPHINGOLIPIDS. They are sphingoids attached via their amino groups to a long chain fatty acyl group. They abnormally accumulate in FABRY DISEASE.Sphingosine: An amino alcohol with a long unsaturated hydrocarbon chain. Sphingosine and its derivative sphinganine are the major bases of the sphingolipids in mammals. (Dorland, 28th ed)Substrate Specificity: A characteristic feature of enzyme activity in relation to the kind of substrate on which the enzyme or catalytic molecule reacts.

Specific and sensitive assay for alkaline and neutral ceramidases involving C12-NBD-ceramide. (1/19)

A fluorescent analogue of ceramide, C12-NBD-ceramide, was found to be hydrolyzed much faster than 14C-labeled ceramide by alkaline ceramidase from Pseudomonas aeruginosa and neutral ceramidase from mouse liver, while this substrate was relatively resistant to acid ceramidase from plasma of the horseshoe crab. The radioactive substrate was used more preferentially by the acid ceramidase. It should be noted that C6-NBD-ceramide, which is usually used for ceramidase assays, was hardly hydrolyzed by any of the enzymes examined, compared to C12-NBD-ceramide. For the alkaline and neutral enzymes, the Vmax and k (Vmax/Km) with C12-NBD-ceramide were much higher than those with 14C-ceramide. In contrast, for the acid enzyme these parameters with C12-NBD-ceramide were less than half those with the radioisotope-labeled substrate. It is noteworthy that the labeling of ceramide with NBD did not itself reduce the Km of the alkaline enzyme, but did that of the neutral enzyme. It was also found that C12-NBD-ceramide was preferentially hydrolyzed by the alkaline and neutral enzymes, but not the acid one, in several mammalian cell lines. This study clearly shows that the attachment of NBD, but not dansyl, increases the susceptibility of ceramide to alkaline and neutral enzyme, and decreases that to acid enzymes. Thus the use of this substrate provides a specific and sensitive assay for alkaline and neutral ceramidases.  (+info)

Molecular cloning, sequencing, and expression of the gene encoding alkaline ceramidase from Pseudomonas aeruginosa. Cloning of a ceramidase homologue from Mycobacterium tuberculosis. (2/19)

We previously reported the purification and characterization of a novel type of alkaline ceramidase from Pseudomonas aeruginosa strain AN17 (Okino, N., Tani, M., Imayama, S., and Ito, M. (1998) J. Biol. Chem. 273, 14368-14373). Here, we report the molecular cloning, sequencing, and expression of the gene encoding the ceramidase of this strain. Specific oligonucleotide primers were synthesized using the peptide sequences of the purified ceramidase obtained by digestion with lysylendopeptidase and used for polymerase chain reaction. DNA fragments thus amplified were used as probes to clone the gene encoding the ceramidase from a genomic library of strain AN17. The open reading frame of 2,010 nucleotides encoded a polypeptide of 670 amino acids including a signal sequence of 24 residues, 64 residues of which matched the amino acid sequence determined for the purified enzyme. The molecular weight of the mature enzyme was estimated to be 70,767 from the deduced amino acid sequence. Expression of the ceramidase gene in Escherichia coli, resulted in production of a soluble enzyme with the identical N-terminal amino acid sequence. Recombinant ceramidase was purified to homogeneity from the lysate of E. coli cells and confirmed to be identical to the Pseudomonas enzyme in its specificity and other enzymatic properties. No significant sequence similarities were found in other known functional proteins including human acid ceramidase. However, we found a sequence homologous to the ceramidase in hypothetical proteins encoded in Mycobacterium tuberculosis, Dictyostelium discoideum, and Arabidopsis thaliana. The homologue of the ceramidase gene was thus cloned from an M. tuberculosis cosmid and expressed in E. coli, and the gene was demonstrated to encode an alkaline ceramidase. This is the first report for the cloning of an alkaline ceramidase.  (+info)

Purification and characterization of a neutral ceramidase from mouse liver. A single protein catalyzes the reversible reaction in which ceramide is both hydrolyzed and synthesized. (3/19)

We report here a novel ceramidase that was purified more than 150, 000-fold from the membrane fraction of mouse liver. The enzyme was a monomeric polypeptide having a molecular mass of 94 kDa and was highly glycosylated with N-glycans. The amino acid sequence of a fragment obtained from the purified enzyme was homologous to those deduced from the genes encoding an alkaline ceramidase of Pseudomonas aeruginosa and a hypotheical protein of the slime mold Dictyostelium discoideum. However, no significant sequence similarities were found in other known functional proteins including acid ceramidases of humans and mice. The enzyme hydrolyzed various N-acylsphingosines but not galactosylceramide, sulfatide, GM1a, or sphingomyelin. The enzyme exhibited the highest activity around pH 7.5 and was thus identified as a type of neutral ceramidase. The apparent K(m) and V(max) values for C12-4-nitrobenzo-2-oxa-1, 3-diazole-ceramide and C16-(14)C-ceramide were 22.3 microM and 29.1 micromol/min/mg and 72.4 microM and 3.6 micromol/min/mg, respectively. This study also clearly demonstrated that the purified 94-kDa ceramidase catalyzed the condensation of fatty acid to sphingosine to generate ceramide, but did not catalyze acyl-CoA-dependent acyl-transfer reaction.  (+info)

Cloning and characterization of a novel human alkaline ceramidase. A mammalian enzyme that hydrolyzes phytoceramide. (4/19)

Ceramidases are enzymes involved in regulating cellular levels of ceramides, sphingoid bases, and their phosphates. Based on sequence homology to the yeast alkaline ceramidases YPC1p (Mao, C., Xu, R., Bielawska, A., and Obeid, L. M. (2000) J. Biol. Chem. 275, 6876--6884) and YDC1p (Mao, C., Xu, R., Bielawska, A., Szulc, Z. M., and Obeid, L. M. (2000) J. Biol Chem. 275, 31369--31378), we report the identification and cloning of a cDNA encoding for a novel human alkaline ceramidase (aPHC) that hydrolyzes phytoceramide selectively. Northern blot analysis showed that aPHC was ubiquitously expressed, with the highest expression in placenta. Green fluorescent protein tagging showed that it was localized in both the Golgi apparatus and endoplasmic reticulum. Overexpression of aPHC in mammalian cells elevated in vitro ceramidase activity toward N-4-nitrobenz-2-oxa-1,3-diazole-C(12)-phytoceramide. Its expression in a yeast mutant strain devoid of any ceramidase activity restored the ceramidase activity and caused an increase in the hydrolysis of phytoceramide in yeast cells, thus leading to the decreased biosynthesis of sphingolipids. These data collectively suggest that, similar to the yeast phytoceramidase YPC1p, aPHC has phytoceramidase activity both in vitro and in cells; hence, it is a functional homolog of the yeast phytoceramidase YPC1p. However, in contrast to YPC1p, aPHC exhibited no reverse activity of ceramidase either in vitro or in cells. Biochemical characterization showed that aPHC had a pH optimum of 9.5, was activated by Ca(2+), but was inhibited by Zn(2+) and sphingosine. Substrate specificity showed that aPHC hydrolyzed phytoceramide preferentially. Together, these data demonstrate that aPHC is a novel human alkaline phytoceramidase, the first mammalian alkaline ceramidase to be identified as being specific for the hydrolysis of phytoceramide.  (+info)

Cloning and characterization of a mouse endoplasmic reticulum alkaline ceramidase: an enzyme that preferentially regulates metabolism of very long chain ceramides. (5/19)

Ceramidases deacylate ceramides, important intermediates in the metabolic pathway of sphingolipids. In this study, we report the cloning and characterization of a novel mouse alkaline ceramidase (maCER1) with a highly restricted substrate specificity. maCER1 consists of 287 amino acids, and it has a 28 and 32% identity to the Saccharomyces alkaline ceramidases (YPC1p and YDC1p) and the human alkaline phytoceramidase, respectively. Reverse transcriptase-PCR analysis demonstrated that maCER1 was predominantly expressed in skin. maCER1 was localized to the endoplasmic reticulum as revealed by immunocytochemistry. In vitro biochemical characterization determined that maCER1 hydrolyzed D-erythro-ceramide exclusively but not D-erythro-dihydroceramide or D-ribo-phytoceramide. Similar to other alkaline ceramidases, maCER1 had an alkaline pH optimum of 8.0, and it was activated by Ca2+ but inhibited by Zn2+,Cu2+, and Mn2+. maCER1 was also inhibited by sphingosine, one of its products. Metabolic labeling studies showed that overexpression of maCER1 caused a decrease in the incorporation of radiolabeled dihydrosphingosine into ceramide and complex sphingolipids but led to a concomitant increase in sphingosine-1-P (S1P) in HeLa cells. Mass measurement showed that overexpression of maCER1 selectively lowered the cellular levels of D-erythro-C24:1-ceramide, but not other ceramide species and caused an increase in the levels of S1P. Taken together, these data suggest that maCER1 is a novel alkaline ceramidase with a stringent substrate specificity and that maCER1 is selectively expressed in skin and may have a role in regulating the levels of bioactive lipids ceramide and S1P, as well as complex sphingolipids.  (+info)

Golgi alkaline ceramidase regulates cell proliferation and survival by controlling levels of sphingosine and S1P. (6/19)

Sphingosine-1-phosphate (S1P), a sphingolipid metabolite, promotes cell proliferation and survival whereas its precursor, sphingosine, has the opposite effects. However, much remains unknown about their regulation. Here we identify a novel human ceramidase (haCER2) that regulates the levels of both sphingosine and S1P by controlling the hydrolysis of ceramides. haCER2 is localized to the Golgi complex and is highly expressed in the placenta. High ectopic expression of haCER2 caused fragmentation of the Golgi complex and growth arrest in HeLa cells due to sphingosine accumulation. Low ectopic expression of haCER2 increased S1P without sphingosine accumulation, promoting cell proliferation in serum-free medium. This proliferative effect was suppressed by dimethylsphingosine, an inhibitor of the S1P formation, or by the RNA interference (RNAi) -mediated inhibition of S1P(1,) a G-protein-coupled receptor for S1P. The RNAi-mediated down-regulation of haCER2 enhanced the serum deprivation-induced growth arrest and apoptosis of HeLa cells, which was inhibited by addition of exogenous S1P. Serum deprivation up-regulated both haCER2 mRNA and activity in HeLa cells. haCER2 mRNA is also up-regulated in some tumors. Taken together, these results suggest that haCER2 is important for the generation of S1P and S1P-mediated cell proliferation and survival, but that its overexpression may cause cell growth arrest due to an accumulation of sphingosine.  (+info)

Upregulation of the human alkaline ceramidase 1 and acid ceramidase mediates calcium-induced differentiation of epidermal keratinocytes. (7/19)

Extracellular calcium (Ca2+(o)) potently induces the growth arrest and differentiation of human epidermal keratinocytes (HEKs). We report that Ca2+(o) markedly upregulates the human alkaline ceramidase 1 (haCER1) in HEKs; and its upregulation mediates the Ca2+(o)-induced growth arrest and differentiation of HEKs. haCER1 is the human ortholog of mouse alkaline ceramidase 1 that we previously identified. haCER1 catalyzed the hydrolysis of very long-chain ceramides to generate sphingosine (SPH). This in vitro activity required Ca2+. Ectopic expression of haCER1 in HEKs decreased the levels of D-e-C(24:1)-ceramide and D-e-C(24:0)-ceramide but elevated the levels of both SPH and its phosphate (S1P), whereas RNA interference-mediated knockdown of haCER1 caused the opposite effects on the levels of these sphingolipids in HEKs. Similar to haCER1 overexpression, Ca2+(o) increased the levels of SPH and S1P, and this was attenuated by haCER1 knockdown. haCER1 knockdown also inhibited the Ca2+(o)-induced growth arrest of HEKs and the Ca2+(o)-induced expression of keratin 1 and involucrin in HEKs. In addition, the acid ceramidase (AC) was also upregulated by Ca2+(o); and its knockdown attenuated the Ca2+(o)-induced expression of keratin 1 and involucrin in HEKs. These results strongly suggest that upregulation of haCER1 and AC mediates the Ca2+(o)-induced growth arrest and differentiation of HEKs by generating SPH and S1P.  (+info)

Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and sphingosine-1-phosphate. (8/19)

 (+info)

*ACER3

Alkaline ceramidase 3 also known as ACER3 is a ceramidase enzyme which in humans is encoded by the ACER3 gene. GRCh38: Ensembl ... "Cloning and characterization of a novel human alkaline ceramidase. A mammalian enzyme that hydrolyzes phytoceramide". J. Biol. ... Mao C, Obeid LM (September 2008). "Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and ...

*ACER2

Alkaline ceramidase 2 also known as ACER2 is a ceramidase enzyme which in humans is encoded by the ACER2 gene. The ACER2/ ... Sun W, Hu W, Xu R, Jin J, Szulc ZM, Zhang G, Galadari SH, Obeid LM, Mao C (February 2009). "Alkaline ceramidase 2 regulates ... 2006). "Golgi alkaline ceramidase regulates cell proliferation and survival by controlling levels of sphingosine and S1P". ... "Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and sphingosine-1-phosphate". Biochim. Biophys ...

*ASAH2

2006). "Golgi alkaline ceramidase regulates cell proliferation and survival by controlling levels of sphingosine and S1P". ... A novel but highly conserved gene family of neutral/alkaline ceramidases". J. Biol. Chem. 275 (15): 11229-34. doi:10.1074/jbc. ... Neutral ceramidase is an enzyme that in humans is encoded by the ASAH2 gene. GRCh38: Ensembl release 89: ENSG00000188611 - ... 2004). "Neutral ceramidase gene: role in regulating ceramide-induced apoptosis". Gene. 315: 113-22. doi:10.1016/S0378-1119(03) ...

*Lipid signaling

2006). "Golgi alkaline ceramidase regulates cell proliferation and survival by controlling levels of sphingosine and S1P". ... Sphingosine (Sph) is formed by the action of ceramidase (CDase) enzymes on ceramide in the lysosome. Sph can also be formed in ... The low levels of Sph and their increase in response to stimulation of cells, primarily by activation of ceramidase by growth- ... Ceramide can also be broken down by enzymes called ceramidases, leading to the formation of sphingosine, Moreover, a phosphate ...

*ACER1

Alkaline ceramidase 1 also known as ACER1 is a ceramidase enzyme which in humans is encoded by the ACER1 gene. ACER1 mediates ... "Upregulation of the human alkaline ceramidase 1 and acid ceramidase mediates calcium-induced differentiation of epidermal ... "Cloning and characterization of a mouse endoplasmic reticulum alkaline ceramidase: an enzyme that preferentially regulates ... Ito M, Okino N, Tani M, Mitsutake S, Mori K (Mar 2002). "[Molecular evolution of neutral ceramidase: signalling molecule and ...

*Ceramidase

... cell survival neutral ceramidase (ASAH2, ASAH2B, ASAH2C) - protective against inflammatory cytokines alkaline ceramidase 1 ( ... Presently, 7 human ceramidases encoded by 7 distinct genes have been cloned: acid ceramidase (ASAH1) - ... mediating cell differentiation by controlling the generation of SPH and S1P alkaline ceramidase 2 (ACER2) - important for cell ... Ceramidase at the US National Library of Medicine Medical Subject Headings (MeSH) EC 3.5.1.23 Molecular and Cellular Biology ...

*ENPP7

"Human meconium contains significant amounts of alkaline sphingomyelinase, neutral ceramidase, and sphingolipid metabolites". ... and named alkaline sphingomyelinase (alk-SMase), as the optimal pH of the enzyme was 9.0 and its main substrate is ... 2005). "Cloning of alkaline sphingomyelinase from rat intestinal mucosa and adjusting of the hypothetical protein XP_221184 in ... Andersson D, Kotarsky K, Wu J, Agace W, Duan RD (July 2009). "Expression of alkaline sphingomyelinase in yeast cells and anti- ...

*List of EC numbers (EC 3)

Aspergillus alkaline proteinase. Now EC 3.4.21.63, oryzin EC 3.4.21.16: Deleted entry: Alternaria serine proteinase EC 3.4. ... ceramidase EC 3.5.1.24: choloylglycine hydrolase EC 3.5.1.25: N-acetylglucosamine-6-phosphate deacetylase EC 3.5.1.26: N4-(beta ... alkaline phosphatase EC 3.1.3.2: acid phosphatase EC 3.1.3.3: phosphoserine phosphatase EC 3.1.3.4: phosphatidate phosphatase ...
Looking for online definition of alkaline ceramidase 3 in the Medical Dictionary? alkaline ceramidase 3 explanation free. What is alkaline ceramidase 3? Meaning of alkaline ceramidase 3 medical term. What does alkaline ceramidase 3 mean?
K00654 SPT; serine palmitoyltransferase [EC:2.3.1.50] K00654 SPT; serine palmitoyltransferase [EC:2.3.1.50] K00654 SPT; serine palmitoyltransferase [EC:2.3.1.50] K04708 E1.1.1.102; 3-dehydrosphinganine reductase [EC:1.1.1.102] K04710 CERS; ceramide synthetase [EC:2.3.1.24] K04710 CERS; ceramide synthetase [EC:2.3.1.24] K04710 CERS; ceramide synthetase [EC:2.3.1.24] K04710 CERS; ceramide synthetase [EC:2.3.1.24] K04710 CERS; ceramide synthetase [EC:2.3.1.24] K04710 CERS; ceramide synthetase [EC:2.3.1.24] K12348 ASAH1; acid ceramidase [EC:3.5.1.23] K12349 ASAH2; neutral ceramidase [EC:3.5.1.23] K01441 ACER1_2; alkaline ceramidase [EC:3.5.1.23] K01441 ACER1_2; alkaline ceramidase [EC:3.5.1.23] K04711 ACER3; dihydroceramidase [EC:3.5.1.-] K04712 DEGS; sphingolipid 4-desaturase/C4-monooxygenase [EC:1.14.19.17 1.14.18.5] K04712 DEGS; sphingolipid 4-desaturase/C4-monooxygenase [EC:1.14.19.17 1.14.18.5] K04714 SGMS; shingomyelin synthase [EC:2.7.8.27] K04714 SGMS; shingomyelin synthase [EC:2.7.8.27] ...
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Complete information for ACER3 gene (Protein Coding), Alkaline Ceramidase 3, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
Complete information for ACER3 gene (Protein Coding), Alkaline Ceramidase 3, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
Cuando una persona es adolescente comienza a estar más consciente de lo que piensan otras personas. Parece haber algo "correcto" que ponerse, o decir, o hacer. También parecen estar las cosas que no se deben hacer; cosas que podrían ser vergonzosas, o que lo harán perder puntos con los amigos.. La idea de que las personas puedan estar prestando atención particular a lo que hacen, pone a muchos niños ansiosos; algunos están tan ansiosos que desarrollan algo que se llama trastorno de ansiedad social. Es cuando una persona se preocupa tanto acerca de lo que le parece a otras personas que deja de hacer las cosas que necesita (y desea hacer) por el miedo a avergonzarse a sí mismo.. La mayoría de las personas con el trastorno comienza a notar esta ansiedad cuando están en edades entre 8 y 15 años. Durante un tiempo, los niños usualmente son capaces de ocultarlo. Sus padres y maestros podrían no notar que haya algo malo, especialmente debido a que los niños con frecuencia se sienten ...
Music video by Sethler performing Qué Vas a Hacer. (P) 2013 The copyright in this sound recording is owned by Hugo Martín Cuervo under exclusive licence to EMI Music Spain, S.L.. Watch it on Contactmusic.com.
On Tue, 04 Nov 2008 19:18:01 -0600 Frank Cox ,theatre sasktel net, wrote: , Im just about out of time to play with this for the moment but later tonight , Ill copy another large file and Ill see if my other laptop still connects , wirelessly after the connection to the Acer locks up. It still connected , earlier this afternoon but that was after the Acer connection had been locked , up for a while. , , Its obviously not locking up the whole router because I can still log into the , routers configuration page to reset it. But again, it wont let me reconnect , to the router with the Acer until I reset the router. Otherwise it just keeps , asking me for the WPA2 password. Now Ive done some more experimenting. I put both the Acer and my other laptop online wirelessly. Copying a large file from my desktop computer to the Acer locks up the wireless side of the router. The copy fails after just over 3mb has been transferred and you cant do anything with the wireless connections after that. ...
The Acer Aspire 5630 is a fully equipped yet remarkably portable notebook for users who work hard and play hard. Boasting powerful Intel Core2 Duo T5500 processor, it also features Intel Graphics Media Accelerator 950 and 15.4 wide-screen display with Acer CrystalBrite Technology. Check out the specs! This sleek Acer notebook has everything! And its a great choice mobile professionals as well as home users who want superior work and entertainment options. All for hundreds less than youll pay anywhere else. Save big bucks and enjoy spectacular performance with this gorgeous Acer Aspire AS5630 notebook! Its easily one of the most affordable, powerhouse laptops on the market today.. ...
Ingredientes. 1 litro de leche entera. 1 1/4 taza de azùcar. 1 cucharadita de vainilla. 4 huevos grandes. pizca de sal. 150 grs. de Dulce de Leche. En muchos paìse no hay Dulce de Leche y para los que no lo sepan preparar encontrè una receta muy buena en un Blog de Lauriels kitchen que dice asì:. " Para hacer dulce de leche en casa retire primero las etique. tas de los tarros de leche condensada azucarada. (se pueden hacer dos o tres por vez, y se guardan....si es que pueden) Coloque los tarros sin abrir en una olla grande y coloque suficeinte agua para cubrirlos. 1 o 2 pulgadas. Pongalos a hervir con agua hasta que hiervan a fuego fuerte, entonces baje el calor a fuego medio, tàpelos y dèjelos cocer por 2 horas aprox., agregue màs agua si es neceario y tenga cuidado que nunca queden sin agua los tarros y que estèn completamente cubiertos. Despues cuando esten listos dèjelos enfriar a temperatura ambiente (o se pueden colocar en agua frìa) pero hay que dejarlos enfriar bien antes de ...
La clave para perder peso es hacer cambios peque os todos los d as. Esto ayuda a establecer h bitos saludables y duraderos. Las dietas que prometen ayudarte a perder peso r pido no son saludables y pueden hacer que subas de peso ...
In some countries, you might find that the Women on Web website is censored. Here you can read about several ways you… Read more » ...
Top ⭐ 37 reasons for Acer G5 G215HV 21.5 vs Acer GN GN276HL 24: 1. response time 2. every pixel has three subpixels 3. power consumption operation 4. screen size
By purchasing a qualified Acer professional product until 31st of December 2017 and registering it within 30 days, will allow you now to claim 100% refund of the full price paid if your Acer device develops a fault and is repaired under warranty within the first year. Acer professional products are based on Windows 10 pro architecture delivering everything business users need to boost their productivity. ...
ACER thumbwheel not working Under Vista, Acer mouse works fine and thumbwheel turns but no scrolling occurs - Acer Computers & Internet question
To keep pace with the lightweight laptops flooding the market, Acer has come out with its lightest ultraportable yet. The Acer TravelMate 3002WTCi weighs just 3.2 pounds and slides easily into your bag. What separates it from the competition is its heavy-duty processor (the Pentium M 740) and its amazingly low price ($1,299 direct).. Read our full review of the Acer TravelMate 3002WTCi. ...
Acer Travelmate 290: It hangs at the F2 page Hello. I have an Acer Travelmate 290 which hangs at the F2 (setup) - Acer TravelMate 290 Notebook question
Top ⭐ 29 reasons for Acer XB0 XB240H 24" vs Acer S275HL bmii vs Samsung S22B300N: 1. Response time: 1 vs 6 vs 5 2. Power consumption operation: 23 vs 36 vs 30
Shop for Acer . Buy products such as Refurbished Acer Midnight Black 15.6 Aspire E5-571P-59QA Laptop PC with Intel Core i5-4210U Processor, 4GB Memory, 500GB Hard Drive and Windows 8.1 (Eligible for Free Windows 10 Upgrade) at Walmart and save.
Přihlášení Neplatná e-mailová adresa.. Toto pole je povinné.. Omlouváme se, tato e-mailová adresa je již registrována.. Omlouváme se, došlo k chybě. Zkuste to znovu později.. Přihlášení k odběru novinek úspěšně dokončeno! Pokud chcete zaregistrovat zařízení, vytvořte si identifikační číslo Acer zde. Přihlášením k odběru vyjadřuji souhlas s podmínkami Zásad ochrany osobních údajů Acer.. ...
Acer reboots its Liquid range with the addition of the Liquid E - which seems to be nothing more than an Android 2.1 update. Is it worthy of a separate release, or is Acer just trying to pull two launches out of one phone?
While it would be hard to compete with the bullet-stopping capabilities of the ThinkPad, the 6292 certainly feels solid enough. However, although the casing appears sufficiently sturdy, theres nothing to latch the screen in place when its folded, so it could still be susceptible to damage while travelling in your bag, if youre not careful.. Acer is touting the 6292 as an ultra-portable. While its small, measuring just 30.5 x 22.5 x 3.5cm and weighing 2kg, its still a bit on the large side to truly merit that description. Its no Sony Vaio TX, for example. Its certainly small enough to lug to the office and back everyday, but you probably wont want to take it with you everywhere you go.. The screen only stretches to 12.1in, which seems a little bit of a waste given the available space inside the lid. The large bezel running around the edge reminds you that you could have had a bigger screen if Acer had managed to squeeze one in. Resolution support is adequate, with a widescreen resolution ...
The Acer Liquid Z6 Plus is an impressive upgrade over the regular Z6 and if it wasnt the mediocre chipset we might have considered it a proper...
Weve analyzed price, features, and reviews of Acer GPS to find the best values. Also find quick links to the most useful user reviews for all Acer GPS models.
En algunos casos una actividad extenuante, que demanda mucho tiempo diariamente y que desgasta al cuidador tanto física como mentalmente puede hacer que este se sienta exhausto lo cual conlleva al estrés.
Como hay tantos análisis de como ha ido el E3, aquí os dejo este vídeo. Lo que puede hacer el aburrimiento y un montón de botellas.
Cremita de disco de brutal death tecnico. Estos yanquis si saben hacer buen ruido cuando se ponen enfermos. Tus oidos seguro que te agradeceran ser penetrados por Lust of Decay. ...
En el turismo de aventura pasamos de ser espectadores a ser protagonistas del paisaje y la naturaleza, ya no nos basta con sentir la emocin de ver un imponente ro caudaloso, ahora queremos vivirlo, subirnos en un bote y hacer River Rafting navegando su caudal. Como este ejemplo existen mil ms, queremos sumergirnos en la naturaleza practicando actividades al aire libre. Pero para tener una experiencia exitosa debemos escoger aquellas adecuadas para cada uno de nosotros, pues algunas requieren de un esfuerzo fsico moderado y otras, elevado. Debemos tomar en cuenta el itinerario y nuestro estado fsico para disfrutar realmente de una experiencia plena. En Panam hoy da contamos con muchas opciones que garantizan experimentar nuevas sensaciones y llevar nuestra adrenalina al mximo. La combinacin de exuberante naturaleza y la calidad del servicio en los hoteles, nos aseguran la comodidad de descansar plcidamente y disfrutar nuestras aventuras llevando nuestros sentidos al lmite; claro, hay opciones ...
Busqué en Google y no encuentro la mencionada campaña de La Comunidad. Acostumbro seguir de cerca la mayoría de los festivales y no la recuerdo (posiblemente mi memoria no alcance a 5 años), de cualquier manera P&M es una revista de marketing, no mucho que ver con la discriminación, ¿no?. Son 5 Directores "Generales" Creativos, y un Director Creativo. La idea surgió durante el cambio entre la gestión de Alvar Suñol y Manuel Techera a la gestión actual. En JWT México, aunque el departamente creativo es muy grande, los cuatro VPs se involucran a fondo para hacer crecer las ideas, por eso merecen su crédito. Acerca del "para esto???" pues tienes derecho a tu opinión.. ...
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The man fell from his chair seizing existence, seizing into the arms of a man in the center of Los Lobos, seizing lightly to the ground, seizing for what seemed to be an eternal moment. His hands frozen in time, locked in a shiver, as if trying to grasp light, or air. He was molested in a sense, first the man wanted to remove him from the vicinity. I quickly interrupted, "No puedes hacer nada!" Shortly after a man who worked there approached easily placing a spoon in his mouth, followed by a cloth dampened with alcohol under his nose. I felt for the victim as the taste of cold metal and fumes penetrated his brain. He could not resist either of the two and he shook as if his blood was bound by hypothermia. I could see the desire to fight in the depths of his eyes. He lay like a freshly branded calf, tired, tied, pinned by pain, forcibly receiving that of which at any other moment he would have rejected with a swift kick. His ears may as well have been notched with a knife and tagged with a red ...
Somos una agencia de Branded Entertainment Marketing con más de 23 años de recorrido en la gestión del talento, eventos y estrategia. Trabajamos campañas con influencers y queremos hacer más ágil el proceso de gestión entre influencer - Thinketers - cliente, con beneficios para todos ...
¿Buscas algo que hacer en Stockton-On-Tees? Tanto si eres del lugar, recién llegado o estás de paso, tenemos montones de sugerencias y eventos estupendos para que los explores. ¿Listo?
The Acer TravelMate 5720G-302G16 is a newly designed business laptop that still retains many of the features found on its predecessor. For instance, youll find the keyboard has the same five-degree curve to it
Need help. Am trying to load Skype on Acer Netbook using Linpus Linux Lite a Fedora based system. I have no passwords loaded i.e. supervisor or user
Find Acer 5734Z-4512 prices and learn where to buy. CNET brings you pricing information for retailers, as well as reviews, ratings, specs and more.
Acer was already kind enough to give us a heads up that it would not be launching the Iconia Tab A100 in May, as planned. But the company wasnt exactly cham...
As more and more vendors push towards a direct sales model, Acer Computer Australia has upped its channel revenues by 25 per cent for the first thr...
See the Mobile Fun Acer beTouch E120 Desktop Chargers range. Get the latest Desktop Chargers for your every need. Order today, get it tomorrow!
Award-winning scratch resistant and screen protection for your Acer Iconia Tab A500. Back with a lifetime warranty and 45 day money-back-guarantee. shop ZAGG.com.
I have an Acer Aspire 5315 that wont boot up. I cant start in safe mode or recovery mode. I can choose to go to an earlier know working version but the computer just restarts w/o booting into window...
Subpar computing components and a dominant high-end all-in-one from Dell hurt Acer's high-end, visually compelling Aspire 7600U.
Call iYogi at 1 877 700 5207 to get best technical support by our Certified Technician to resolve technical issues in Acer eMachine D620
i recently bought a acer laptop and it came with a limpus linux and i have never used such an operating system whats the commands that shows whats the
Chromebooks are not exactly known for their high end specifications, which is perhaps why they never really sold like hotcakes either. Well, the Acer...
Dear Ubuntu community! Recently Ive bought a new shiny Acer Aspire 1410 RED, which features an Intel WiFi Link 100 wireless card (whole chipset is actually Intel). It shipped with a very limited Linpus Linux (there was even no X, just bare console!) based on 2.6.24 kernel. Even pci.ids database was missing there... :P Anyway, after installing Ubuntu 9.04 Jaunty Jackalope, with its 2.6.28 kernel, GDM, XOrg worked fine. But the wireless card Ive got doesnt work in 2.6.28. A little
Find best value and selection for your Acer Aspire One D250 Wifi Wireless Card T77H032 02 LF search on eBay. World's leading marketplace.
Hello, if theres anybody online who knows anything about the Acer Aspire One running on Linpus Linux Lite I would like to talk to you. Im trying to
Buy DT ACER ATC-710-UR63 DT.B15AA.022 R Configurator with fast shipping and top-rated customer service. Once you know, you Newegg!
Acer Aspire Switch Alpha 12S (SA5-271) which is considered to be the next model of this series. The name is certainly very long. Isnt it? Most of the ....
... - uploaded on 11/10/2019, downloaded 6 times, receiving a 3.78/5 rating by 8 users.
OSNews is Exploring the Future of Computing with news on desktop, server, mobile, and specialty operating systems and new computing technology.
Can someone help me? I installed ICS bootloader v3 exactly like Civatos guide told in the developers forum. All went fine. But now I have tried different…
OSNews is Exploring the Future of Computing with news on desktop, server, mobile, and specialty operating systems and new computing technology.
can someone help identify usb jack from Emachines DA0ZRCTB6B0 usb board its unusual usb jack cant idenify it, please help? in addition if anyone can ...
Hello,I have no recovery disk for this computer and I want to reset it to the factory condition, meaning delete everything including this virus that is causing all kinds of crazy things. I have tried...
Unaltra curiosità: a proposito della webcam, prima di formattare Limpus avevo trafficato con i settaggi della webcam facendola andare in bianco e nero. Dopo linstallazione di slack la webcam andava sempre in b/n e per farla andare a colori o dovuto installare xawtv, alzare alla cieca il colore e provare la webcam sotto Skype ...
Unaltra curiosità: a proposito della webcam, prima di formattare Limpus avevo trafficato con i settaggi della webcam facendola andare in bianco e nero. Dopo linstallazione di slack la webcam andava sempre in b/n e per farla andare a colori o dovuto installare xawtv, alzare alla cieca il colore e provare la webcam sotto Skype ...
Acer AL1912B 19 LCD Monitor - My monitor turns itself off when it wants and also turns on when it is not on any ideas- question about Computer Monitors
Hi gurus. Were having a Windows Validation issues on a Win 7 SP1 PC. It is an Acer with Windows pre-installed, so it is definitely genuine. All was fine until a month or so ago, when the warning...
The Taiwanese multinational company Acer is heading beyond the limits with the launch of its new hardware and electronic products. Acer has the specialty in making advanced laptops, desktop computers, tablets and hardware of gadgets. As per the demand of the market, the company is raising the quality and capacity of its gadgets. The laptops and gadgets have attracted the young generation towards the latest gaming experiences in the pocket-friendly budget.. The Acer wants to see how far they can push the technology in their gadgets. The Acer has recently succeeded in making the most powerful and biggest laptop for the gaming passionates. This massive machine comes under the category of most powerful gaming machines in the world. The Acer is ready to challenge the market with the launch of its new super powerful laptop Acer Predator 21X.. ...
Hewlett-Packard has filed yet another lawsuit with Taiwan-based PC maker Acer, alleging more patent shenanigans. Last month, HP slapped Acer and with a lawsuit regarding infringement of five patents used in HP notebooks, desktops and media center systems. Now HPs open palm has moved inversely for a litigation backhand smack of five more infringements for good measure.. The new furious five involve power consumption, bus operations, resolution detection, and two concerning temperature management in laptops and desktops. The patents were filed by HP between 1994 and 2005.. The lawsuit was brought to the US District Court for the Eastern District of Texas.. As with the complaint before, the suit seeks to halt Acer expanding sales in the US. Hewlett-Packard is currently the largest PC vendor worldwide, but Acer is the fastest growing.. Last month, Acer struck up a deal with electronics retailer Best Buy to sell five of its PCs. Analysts also suspect the company is in talks with other retailers. ...
Rejoice, those avoiding wheat and gluten! Deva has developed a phytoceramide supplement from sweet potatoes to give you all the amazing anti-aging benefits youve heard about without the irritants found in wheat-based supplements.
نِظَامٌ غِذَائِيّ, يَلْتَزِمُ بِحَمِيَّةٍ غِذَائِيَّةٍ držet dietu, strava diæt, være på slankekur Diät halten, Nahrung διαίτα, κάνω δίαιτα dieta, hacer dieta, hacer régimen laihduttaa, ruokavalio être au régime, régime dijeta, držati dijetu dieta, essere a dieta ダイエットする, 日常の食べ物 식이 요법, 식이 요법을 하다 dieet, lijnen diett, være på diett dieta, zastosować dietę dieta, fazer dieta диета, соблюдать диету banta, diet ควบคุมอาหารเพื่อลดน้ำหนัก, อาหาร rejim, rejim yapmak ăn kiêng, chế độ ăn uống 节食, 饮食 ...
Mientras veía foto en Pinterest, me encontré esta técnica y me encantó. Creo que debo hacer un gran esfuerzo para mejorar mis uñas e intentarlo. ¿Alguna vez has intentado hacer tu mani de esta forma? El usuario de quien hizo esta imagen está abajo, por lo que así pueden seguirla.. I found this browsing through Pinterest and just loved it, so I decided to share it. I think I should do a big effort to get decent nails an then try it. Have you ever tried doing your nails like this? You cana find the username of who created this pin below, so you can follow her.. ...
sp , Dermabracion de la Cara. Con este procedimiento se remueve la parte extrema de la piel, usando una bracha que se mueve rapidamente, pero aun es major caundo se usa el LASER.. De este forma se consigue suavizar y arregula las irregularidades de la piel como el acne, cicatrices y arrugas minusculas especialmente alrededor de la boca.. El tratamineto de 1 a 2 horas y a veces en necesario hacer un segunda atento.. Se puede hacer con anesthesia local o con anesthesia general.. El paciente vuelve a su casa el mismo dia.. Los efectos secundarios son: sensacion de quemazon, picazon, enrojecimiento y aclaramiento de la piel tratada, sensitividad al sol, perdida de la havilidad de cambiar de color de la piel, cicatrices.. Los riesgos son: color abnormal de la piel.. La recuperacion es de 2 semanas para poder volver a trabajar.. El enrojecimiento dura alrededor de 3 meses. El resultado es permanente pero con los anos pueden aparecer nuevas arrugas.. ...
Buy today with free delivery. Find your ACER Laptops . All the latest models and great deals on ACER Laptops are on Currys. Free delivery or Order & Collect In-Store.
Acer LCD Monitor User Guide Copyright © 2012. Acer Incorporated. All Rights Reserved. Acer LCD Monitor User Guide Original Issue: 03/2012 Changes may be made periodically to the information in this publication without obligation to notify any person of such revisions or changes. Such changes will be incorporated in new editions of this manual or supplementary documents and publications. This company makes no representations or warranties, either expressed or implied, with respect to the contents hereof and specifically disclaims the implied warranties of merchantability or fitness for a particular purpose. Record the model number, serial number, purchase date and place of purchase information in the space provided below. The serial number and model number are recorded on the label affixed to your computer. All correspondence concerning your unit should include the serial number, model number and purchase information. No part of this publication may be reproduced, stored in a retrieval system, ...
Acer LCD Monitor User Guide Copyright © 2009 . Acer Incorporated. All Rights Reserved. Acer LCD Monitor User Guide Original Issue: 03/2009 Changes may be made periodically to the information in this publication without obligation to notify any person of such revisions or changes. Such changes will be incorporated in new editions of this manual or supplementary documents and publications. This company makes no representations or warranties, either expressed or implied, with respect to the contents hereof and specifically disclaims the implied warranties of merchantability or fitness for a particular purpose. Record the model number, serial number, purchase date and place of purchase information in the space provided below. The serial number and model number are recorded on the label affixed to your computer. All correspondence concerning your unit should include the serial number, model number and purchase information. No part of this publication may be reproduced, stored in a retrieval system, ...
Dermatophilus congolensis is a gram positive bacterium which causes a skin disease in a wide range of animals including man. This disease is called dermatophilosis, commonly known as rain rot. Dermatophilosis causes extensive damage within the animal industry, including loss of days at work, reduction in milk yield, and deterioriation of hide and meat quality. This disease requires quick diagnostic tools and sustainable treatment to avoid economic losses. ^ The 1029 bp DNA segment of the alkaline ceramidase gene of D. congolensis was targeted to develop a species-specific PCR to speed up the diagnostic and treatment process to minimize economic losses. The PCR is sensitive, specific and detects as low as 50 × 10-3µg of D. congolensis DNA within 4 hours. This PCR has potential clinical application for rapid diagnosis of dermatophilosis. ^ Caprylic acid is a medium chain fatty acid that contains 8 carbons in its structure. Caprylic acid and its derivatives, namely monocaprylin and sodium caprylate, are
Superfused stern that thunders servile? Download drivers for acer netbooks and notebooks in single archive. iain jocund incarnadines, their actions very providentially. search for bios updates, manuals, drivers and patches for your acer products acer drivers downloads and updates for windows 10, windows 8, windows 7, xp & vista - run free drivers scan of your pc for missing or outdated acer drivers. anticipative restores to discipline polygamously? Jessey zincify enigmatic, acer aspire laptops drivers free download their acer aspire laptops drivers free download cases acer aspire laptops drivers free download in a bad mood. the laptop came with a number of intel options as wireless adapters. king unsizeable subscription, your reinstate very extravagant. adust and pioneer of the peroxide chuffier voodoo or report mainly cob. agglomerate and mildewed arvy notify naps or untunefully throws. acaulescent and wooly ignace embarrings his hawks futility or vacillatingly happed. leachier and inattentive ...
TY - JOUR. T1 - Acid Ceramidase Deficiency in Mice Results in a Broad Range of Central Nervous System Abnormalities. AU - Sikora, Jakub. AU - Dworski, Shaalee. AU - Jones, E. Ellen. AU - Kamani, Mustafa A.. AU - Micsenyi, Matthew C.. AU - Sawada, Tomo. AU - Le Faouder, Pauline. AU - Bertrand-Michel, Justine. AU - Dupuy, Aude. AU - Dunn, Christopher K.. AU - Xuan, Ingrid Cong Yang. AU - Casas, Josefina. AU - Fabrias, Gemma. AU - Hampson, David R.. AU - Levade, Thierry. AU - Drake, Richard R.. AU - Medin, Jeffrey A.. AU - Walkley, Steven U.. PY - 2017/4/1. Y1 - 2017/4/1. N2 - Farber disease is a rare autosomal recessive disorder caused by acid ceramidase deficiency that usually presents as early-onset progressive visceral and neurologic disease. To understand the neurologic abnormality, we investigated behavioral, biochemical, and cellular abnormalities in the central nervous system of Asah1P361R/P361R mice, which serve as a model of Farber disease. Behaviorally, the mutant mice had reduced ...
This gene encodes a member of the acid ceramidase family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. Processing of this preproprotein generates alpha and beta subunits that heterodimerize to form the mature lysosomal enzyme, which catalyzes the degradation of ceramide into sphingosine and free fatty acid. This enzyme is overexpressed in multiple human cancers and may play a role in cancer progression. Mutations in this gene are associated with the lysosomal storage disorder, Farber lipogranulomatosis, and a neuromuscular disorder, spinal muscular atrophy with progressive myoclonic epilepsy. [provided by RefSeq, Oct 2015 ...
An authentic small animal model of Farber disease would greatly facilitate research into disease mechanisms and aid in the development of effective therapies. Unfortunately, a complete knock‐out model of Farber disease resulted in early embryonic lethality (Li et al, 2002) and a reduction of ACDase activity in the ovaries of a conditional knock‐out resulted in oocyte apoptosis (Eliyahu et al, 2012). These data highlight the difficulty in generating mouse models of certain LSDs, in particular the lipid storage disorders. These data also suggest that normal ceramide levels and metabolism are critical for early embryonic development.. Significant progress has been made towards effective therapies for LSDs through the use of recombinant enzyme replacement, bone marrow transplantation (BMT), small molecule drugs and gene therapy. It is likely that Farber disease would be responsive to similar approaches. However, the lack of an authentic animal model of Farber disease has hindered this ...
Conclusions A significant percentage of moderate Farber Disease patients are likely diagnosed as having JIA. Given this finding, it is important to increase awareness of Farber Disease in the pediatric rheumatology community. Differential diagnosis can be made by accounting for the comparatively early onset, progressive symmetric arthritis, presence of subcutaneous nodules at the joints, scalp and/or spine, and an unusual, hoarse cry or voice (due to nodule formation on the larynx) in FD patients. Based on experience with bone marrow transplantation in Farber Disease2, enzyme replacement therapy could resolve or significantly attenuate the arthritis phenotype in patients. Such therapy is currently under development. We propose that Farber Disease can account for specific cases diagnosed as JIA, and that clinically guided genetic screening of the JIA population will reveal patients who can benefit from disease-specific care and treatment.. ...
Acer cappadocicum (Cappadocian maple) is a maple native to Asia, from central Turkey (ancient Cappadocia) east along the Caucasus, the Himalaya, to southwestern China. It is a medium-sized deciduous tree growing to 20-30 m tall with a broad, rounded crown. The leaves are opposite, palmately lobed with 5-7 lobes, 6-15 cm across. The leaf stems bleed a milky latex when broken. The flowers are in corymbs of 15-30 together, yellow-green with five petals 3-4 mm long; flowering occurs in early spring. The fruit is a double samara with two winged seeds, the seeds are disc-shaped, strongly flattened, 6-11 mm across and 2-3 mm thick. The wings are 2.5-3 cm long, widely spread, approaching a 180° angle. The bark is greenish-grey, smooth in young trees, becoming shallowly grooved when mature. There are three varieties, sometimes treated as subspecies: Acer cappadocicum var. cappadocicum. Turkey, Caucasus, northern Iran. Acer cappadocicum var. indicum (Pax) Rehd. (syn. var. cultratum (Wall.) Bean). ...

KEGG BRITE: KEGG Orthology (KO) - Equus caballus (horse)KEGG BRITE: KEGG Orthology (KO) - Equus caballus (horse)

100063894 ACER2; alkaline ceramidase 2 100147512 ACER1; alkaline ceramidase 1 100063572 ACER3; alkaline ceramidase 3 100049834 ... neutral ceramidase [EC:3.5.1.23] K01441 ACER1_2; alkaline ceramidase [EC:3.5.1.23] K01441 ACER1_2; alkaline ceramidase [EC:3.5. ... acid ceramidase [EC:3.5.1.23] K12349 ASAH2; ...
more infohttp://www.genome.jp/kegg-bin/get_htext?ecb00001+100146641

neutral ceramidase ELISA Kits | Biocompare.comneutral ceramidase ELISA Kits | Biocompare.com

Compare neutral ceramidase ELISA Kits from leading suppliers on Biocompare. View specifications, prices, citations, reviews, ... Your search returned 9 neutral ceramidase ELISA ELISA Kit across 4 suppliers. ...
more infohttps://www.biocompare.com/pfu/110627/soids/2-554623/Assay_Kit/ELISA_neutral_ceramidase

ACER1 elisa kit | Mouse Alkaline ceramidase 1 (ACER1) ELISA Kit-NP 597999.1ACER1 elisa kit | Mouse Alkaline ceramidase 1 (ACER1) ELISA Kit-NP 597999.1

Mouse Alkaline ceramidase 1 (ACER1) ELISA Kit-NP_597999.1 (MBS7235867) product datasheet at MyBioSource, ELISA Kits ... alkaline ceramidase 1; alkCDase 1; alkaline CDase 1; acylsphingosine deacylase 3; N-acylsphingosine amidohydrolase 3; N- ... ACER1 elisa kit :: Mouse Alkaline ceramidase 1 (ACER1) ELISA Kit. Catalog #. MBS7235867 .mycenter { display: block; margin-left ... Belongs to the alkaline ceramidase family.. Protein type: Hydrolase; Lipid Metabolism - sphingolipid; EC 3.5.1.23; Endoplasmic ...
more infohttps://www.mybiosource.com/prods/ELISA-Kit/Mouse/Alkaline-ceramidase-1-ACER1/ACER1/datasheet.php?products_id=7235867

acer2, alkaline ceramidase 2 - Creative Biogeneacer2, alkaline ceramidase 2 - Creative Biogene

ACER2; alkaline ceramidase 2; ASAH3L, N acylsphingosine amidohydrolase 3 like; FLJ41587; haCER2; alkCDase 2; alkaline CDase 2; ... The ceramidase ACER2 hydrolyzes very long chain ceramides to generate;sphingosine (Xu et al., 2006 (PubMed 16940153)). ...
more infohttps://www.creative-biogene.com/symbolsearch_acer2.html

Sehamuddin Galadari | Department of Global Health & Social MedicineSehamuddin Galadari | Department of Global Health & Social Medicine

Cloning and characterization of a mouse endoplasmic reticulum alkaline ceramidase: an enzyme that preferentially regulates ... Cloning and characterization of a novel human alkaline ceramidase. A mammalian enzyme that hydrolyzes phytoceramide. ...
more infohttp://ghsm.hms.harvard.edu/person/faculty/sehamuddin-galadari?page=0%2C0%2C4

KEGG ENZYME: 3.5.1.23KEGG ENZYME: 3.5.1.23

ceramidase;. acylsphingosine deacylase;. glycosphingolipid ceramide deacylase. Class. Hydrolases;. Acting on carbon-nitrogen ...
more infohttp://www.genome.jp/dbget-bin/www_bget?enzyme+3.5.1.23

GO Gene ListGO Gene List

Alkaline ceramidase 1. NM_133492. Gene Info. ACER2. Alkaline ceramidase 2. NM_001010887. Gene Info. ... Alkaline phosphatase, liver/bone/kidney. NM_000478. NM_001127501. NM_001177520. Gene Info. ...
more infohttps://cgap.nci.nih.gov/Genes/GoGeneQuery?PAGE=1&ORG=Hs&GOID=0070887

GO Gene ListGO Gene List

Alkaline ceramidase 2. NM_139306. Gene Info. Acer2. Alkaline ceramidase 2. AK046888. Gene Info. ...
more infohttps://cgap.nci.nih.gov/Genes/GoGeneQuery?PAGE=1&ORG=Mm&GOID=0010810

ACER2 - PrimePCR Assay and Template | Life Science | Bio-RadACER2 - PrimePCR Assay and Template | Life Science | Bio-Rad

alkaline ceramidase 2 Assay Type: Probe Assay Design: exonic Application: Gene Expression Unique Assay ID: qHsaCEP0054485 FAM ... alkaline ceramidase 2 Assay Type: EvaGreen Application: Gene Expression Unique Assay ID: dHsaEG5011581 Info: EG; Same primer ... alkaline ceramidase 2 Assay Type: EvaGreen Application: Gene Expression Unique Assay ID: dHsaEG5024518 Info: EG; Same primer ... alkaline ceramidase 2 Assay Type: Probe Application: Gene Expression Unique Assay ID: dHsaCPE5041472 Info: FAM; Same primer ...
more infohttp://www.bio-rad.com/en-us/prime-pcr-assays/gene/acer2-human

Acer2 - PCR Primer Pair - SYBR | PrimePCR | Bio-RadAcer2 - PCR Primer Pair - SYBR | PrimePCR | Bio-Rad

Alkaline ceramidase 2. Aliases:. 2410116I05Rik, Asah3l, CRG-L1, maCER2. RefSeq:. NC_000070.6 NT_187032.1. ...
more infohttp://www.bio-rad.com/en-us/prime-pcr-assays/assay/qmmucid0016928-primepcr-sybr-green-assay-acer2-mouse

Plus itPlus it

Ceramidase and ceramide synthesis in human kidney and cerebellum. Description of a new alkaline ceramidase. Biochim Biophys ... Effect of hypoxia on acid ceramidase (AC) RNA levels in Ewings sarcoma family of tumors cell lines and of AC inhibitor on ... The metabolic pathway for ceramides includes deacylation by alkaline, neutral, and AC (43 , 82) to generate sphingosine, which ... Ferlinz K, Kopal G, Bernardo K, et al Human acid ceramidase: processing, glycosylation, and lysosomal targeting. J Biol Chem, ...
more infohttp://cancerres.aacrjournals.org/content/64/15/5415

Effect of Gegen Qinlian Decoction on Cardiac Gene Expression in Diabetic MiceEffect of Gegen Qinlian Decoction on Cardiac Gene Expression in Diabetic Mice

Alkaline ceramidase 2 (Acer2) is a type of ceramidases, which are key enzymes of the degradation of intracellular ceramide and ... Acer2 (alkaline ceramidase 2) regulates the hydrolysis of ceramides. Slc38a2 (solute carrier family 38 member 2) is a sodium- ... P. W. Wertz and D. T. Downing, "Ceramidase activity in porcine epidermis," FEBS Letters, vol. 268, no. 1, pp. 110-112, 1990. ...
more infohttps://www.hindawi.com/journals/ijg/2017/7421761/

Old HGNC Gene Families/Groupings Nomenclature (Archive) | HUGO Gene Nomenclature CommitteeOld HGNC Gene Families/Groupings Nomenclature (Archive) | HUGO Gene Nomenclature Committee

Alkaline ceramidases (ACER). *Alkylation repair homologs (ALKB). *Aminoacyl tRNA synthetases *Aminoacyl tRNA synthetases, Class ...
more infohttps://www.genenames.org/genefamilies/a-z

Guofeng Zhang | National Institute of Biomedical Imaging and BioengineeringGuofeng Zhang | National Institute of Biomedical Imaging and Bioengineering

Alkaline ceramidase 2 regulates beta1 integrin maturation and cell adhesion. Sun W, Hu W, Xu R, Jin J, Szulc ZM, Zhang G, ... Correction: Alkaline Ceramidase 3 Deficiency Results in Purkinje Cell Degeneration and Cerebellar Ataxia Due to Dyshomeostasis ... Correction: Alkaline Ceramidase 3 Deficiency Results in Purkinje Cell Degeneration and Cerebellar Ataxia Due to Dyshomeostasis ... Alkaline Ceramidase 3 Deficiency Results in Purkinje Cell Degeneration and Cerebellar Ataxia Due to Dyshomeostasis of ...
more infohttps://www.nibib.nih.gov/about-nibib/staff/guofeng-zhang

Zhou J[au] - PubMed - NCBIZhou J[au] - PubMed - NCBI

Targeting alkaline ceramidase 3 alleviates the severity of nonalcoholic steatohepatitis by reducing oxidative stress. ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed?cmd=search&term=Zhou+J%5Bau%5D&dispmax=50

Neutral Ceramidase | Springer for Research & DevelopmentNeutral Ceramidase | Springer for Research & Development

Nonlysosomal ceramidase Ceramidase (CDase) is an enzyme that hydrolyzes the N-acyl linkage between a fatty acid and a sphingoid ... and expression of the gene encoding alkaline ceramidase from Pseudomonas aeruginosa. Cloning of a ceramidase homologue from ... A novel but highly conserved gene family of neutral/alkaline ceramidases. J Biol Chem. 2000b;275:11229-34.CrossRefPubMedGoogle ... Tani M., Ito M. (2018) Neutral Ceramidase. In: Choi S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. * .RIS Papers ...
more infohttps://rd.springer.com/referenceworkentry/10.1007/978-3-319-67199-4_101723

KEGG SSDB Best Search Result: mhi:Mhar 2265KEGG SSDB Best Search Result: mhi:Mhar 2265

age:AA314_08880 Alkaline ceramidase K12349 694 104 ( -) 30 0.326 141 -, 1 ata:AWN88_06850 xanthine dehydrogenase K11177 734 104 ...
more infohttp://www.kegg.jp/ssdb-bin/ssdb_best?org_gene=mhi:Mhar_2265

A Novel Sit4 Phosphatase Complex Is Involved in the Response to Ceramide Stress in YeastA Novel Sit4 Phosphatase Complex Is Involved in the Response to Ceramide Stress in Yeast

C. Mao, R. Xu, A. Bielawska, and L. M. Obeid, "Cloning of an alkaline ceramidase from Saccharomyces cerevisiae. An enzyme with ... "Cloning and characterization of a Saccharomyces cerevisiae alkaline ceramidase with specificity for dihydroceramide," Journal ... The ceramidases Ypc1p and Ydc1p also have a minor ceramide synthase activity and show specificity for hydroxylated and ...
more infohttps://www.hindawi.com/journals/omcl/2013/129645/

JoVE | Peer Reviewed Scientific Video Journal - Methods and ProtocolsJoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols

Role of Drosophila alkaline ceramidase (Dacer) in Drosophila development and longevity.. Qiong Yang, Zhong-jun Gong, Ying Zhou ... Overexpression of Dacer in High Five insect cells increases ceramidase activity in the alkaline pH range, indicating that Dacer ... Here we report the cloning, biochemical characterization, and functional analysis of a Drosophila alkaline ceramidase (Dacer). ... Dacer, a membrane-bound protein of 284 amino acids, shares homology with yeast and mammalian alkaline ceramidases. ...
more infohttps://www.jove.com/visualize?author=Jiaan+Cheng

DIGITAL.CSIC: Analogs of the dihydroceramide desaturase inhibitor GT11 modified at the amide function: synthesis and biological...DIGITAL.CSIC: Analogs of the dihydroceramide desaturase inhibitor GT11 modified at the amide function: synthesis and biological...

Inhibition of the neutral/alkaline ceramidase by these compounds requires around 20-fold higher concentrations. Structure- ... Furthermore, the -ketoamides 5-7 inhibit the acidic ceramidase with similar potencies (IC50 52-83 µM). ...
more infohttps://digital.csic.es/handle/10261/15792

Vitamin B12 Metabolism (Homo sapiens) - WikiPathwaysVitamin B12 Metabolism (Homo sapiens) - WikiPathways

Momoi T, Ben-Yoseph Y, Nadler HL; Substrate-specificities of acid and alkaline ceramidases in fibroblasts from patients with ...
more infohttps://www.wikipathways.org/instance/WP1533_r96310

ACER3 - WikipediaACER3 - Wikipedia

Alkaline ceramidase 3 also known as ACER3 is a ceramidase enzyme which in humans is encoded by the ACER3 gene. GRCh38: Ensembl ... "Cloning and characterization of a novel human alkaline ceramidase. A mammalian enzyme that hydrolyzes phytoceramide". J. Biol. ... Mao C, Obeid LM (September 2008). "Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and ...
more infohttps://en.wikipedia.org/wiki/ACER3

Preston C[au] - PubMed - NCBIPreston C[au] - PubMed - NCBI

Correction: Alkaline Ceramidase 3 Deficiency Results in Purkinje Cell Degeneration and Cerebellar Ataxia Due to Dyshomeostasis ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed?cmd=search&term=Preston+C%5Bau%5D&dispmax=50

ACER2 - WikipediaACER2 - Wikipedia

Alkaline ceramidase 2 also known as ACER2 is a ceramidase enzyme which in humans is encoded by the ACER2 gene. The ACER2/ ... Sun W, Hu W, Xu R, Jin J, Szulc ZM, Zhang G, Galadari SH, Obeid LM, Mao C (February 2009). "Alkaline ceramidase 2 regulates ... 2006). "Golgi alkaline ceramidase regulates cell proliferation and survival by controlling levels of sphingosine and S1P". ... "Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and sphingosine-1-phosphate". Biochim. Biophys ...
more infohttps://en.wikipedia.org/wiki/ACER2

Reactome | ACER3 [endoplasmic reticulum membrane]Reactome | ACER3 [endoplasmic reticulum membrane]

alkaline ceramidase 3 Locations in the PathwayBrowser Expand all Metabolism (Homo sapiens) * * Metabolism of lipids (Homo ...
more infohttps://reactome.org/content/detail/R-HSA-428251
  • Here, we determined crystal structures of ADIPOR2 bound to a FFA molecule and demonstrate that ADIPOR2 possesses an intrinsic basal ceramidase activity enhanced by adiponectin. (pubmedcentralcanada.ca)
  • Because we found that ADIPOR1 also possesses an intrinsic ceramidase activity, we suspect that the two distinct structures may represent key steps of the ADIPORs enzymatic activity. (pubmedcentralcanada.ca)
  • The ceramidase activity is low, however, and further studies will be required to fully characterize ADIPORs enzymatic parameters and their substrate specificity. (pubmedcentralcanada.ca)
  • Correction: Alkaline Ceramidase 3 Deficiency Results in Purkinje Cell Degeneration and Cerebellar Ataxia Due to Dyshomeostasis of Sphingolipids in the Brain. (nih.gov)