A ceramidase subtype that is active at alkaline pH. It is found at high levels within the SMALL INTESTINE.
Amidohydrolases that are specific for the cleavage of the N-acyl linkage of CERAMIDES. Ceramidases are classified as acidic, neutral or basic according to the optimal pH with which they function.
A ceramidase subtype that is active at acid pH. It plays an important role in sphingolipid degradation by catalyzing the lysosomal hydrolysis of ceramide to sphingosine and free fatty acid. Inherited deficiency of acid ceramidase activity results in FARBER LIPOGRANULOMATOSIS.
A ceramidase subtype that is active at neutral pH. It is found at high levels within the SMALL INTESTINE and in the BRAIN.
An enzyme that catalyzes the hydrolysis of a ceramidetrihexoside to a ceramidedihexoside plus galactose.
Members of the class of neutral glycosphingolipids. They are the basic units of SPHINGOLIPIDS. They are sphingoids attached via their amino groups to a long chain fatty acyl group. They abnormally accumulate in FABRY DISEASE.
An amino alcohol with a long unsaturated hydrocarbon chain. Sphingosine and its derivative sphinganine are the major bases of the sphingolipids in mammals. (Dorland, 28th ed)
A characteristic feature of enzyme activity in relation to the kind of substrate on which the enzyme or catalytic molecule reacts.
The chemical reactions involved in the production and utilization of various forms of energy in cells.
A class of membrane lipids that have a polar head and two nonpolar tails. They are composed of one molecule of the long-chain amino alcohol sphingosine (4-sphingenine) or one of its derivatives, one molecule of a long-chain acid, a polar head alcohol and sometimes phosphoric acid in diester linkage at the polar head group. (Lehninger et al, Principles of Biochemistry, 2nd ed)
The external, nonvascular layer of the skin. It is made up, from within outward, of five layers of EPITHELIUM: (1) basal layer (stratum basale epidermidis); (2) spinous layer (stratum spinosum epidermidis); (3) granular layer (stratum granulosum epidermidis); (4) clear layer (stratum lucidum epidermidis); and (5) horny layer (stratum corneum epidermidis).
A subspecialty of internal medicine concerned with the study of the physiology and diseases of the digestive system and related structures (esophagus, liver, gallbladder, and pancreas).
A medical specialty concerned with maintaining health and providing medical care to children from birth to adolescence.
Examination of foods to assure wholesome and clean products free from unsafe microbes or chemical contamination, natural or added deleterious substances, and decomposition during production, processing, packaging, etc.
A malabsorption syndrome that is precipitated by the ingestion of foods containing GLUTEN, such as wheat, rye, and barley. It is characterized by INFLAMMATION of the SMALL INTESTINE, loss of MICROVILLI structure, failed INTESTINAL ABSORPTION, and MALNUTRITION.
A hydrolase enzyme that converts L-asparagine and water to L-aspartate and NH3. EC 3.5.1.1.
Time period from 1501 through 1600 of the common era.
Exclusive legal rights or privileges applied to inventions, plants, etc.
A novel composition, device, or process, independently conceived de novo or derived from a pre-existing model.
Property, such as patents, trademarks, and copyright, that results from creative effort. The Patent and Copyright Clause (Art. 1, Sec. 8, cl. 8) of the United States Constitution provides for promoting the progress of science and useful arts by securing for limited times to authors and inventors, the exclusive right to their respective writings and discoveries. (From Black's Law Dictionary, 5th ed, p1014)
Time period from 1701 through 1800 of the common era.
A set of statistical methods used to group variables or observations into strongly inter-related subgroups. In epidemiology, it may be used to analyze a closely grouped series of events or cases of disease or other health-related phenomenon with well-defined distribution patterns in relation to time or place or both.
Proteins, usually projecting from the cilia of olfactory receptor neurons, that specifically bind odorant molecules and trigger responses in the neurons. The large number of different odorant receptors appears to arise from several gene families or subfamilies rather than from DNA rearrangement.
Body of knowledge related to the use of organisms, cells or cell-derived constituents for the purpose of developing products which are technically, scientifically and clinically useful. Alteration of biologic function at the molecular level (i.e., GENETIC ENGINEERING) is a central focus; laboratory methods used include TRANSFECTION and CLONING technologies, sequence and structure analysis algorithms, computer databases, and gene and protein structure function analysis and prediction.
Neoplasms located in the bone marrow. They are differentiated from neoplasms composed of bone marrow cells, such as MULTIPLE MYELOMA. Most bone marrow neoplasms are metastatic.
A malignant tumor of the bone which always arises in the medullary tissue, occurring more often in cylindrical bones. The tumor occurs usually before the age of 20, about twice as frequently in males as in females.
The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.
Positional isomer of CYCLOPHOSPHAMIDE which is active as an alkylating agent and an immunosuppressive agent.
A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle.
The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.
The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.
The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.
Databases devoted to knowledge about specific genes and gene products.
A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.
A set of genes descended by duplication and variation from some ancestral gene. Such genes may be clustered together on the same chromosome or dispersed on different chromosomes. Examples of multigene families include those that encode the hemoglobins, immunoglobulins, histocompatibility antigens, actins, tubulins, keratins, collagens, heat shock proteins, salivary glue proteins, chorion proteins, cuticle proteins, yolk proteins, and phaseolins, as well as histones, ribosomal RNA, and transfer RNA genes. The latter three are examples of reiterated genes, where hundreds of identical genes are present in a tandem array. (King & Stanfield, A Dictionary of Genetics, 4th ed)
The portion of an interactive computer program that issues messages to and receives commands from a user.
The relationships of groups of organisms as reflected by their genetic makeup.
A publication issued at stated, more or less regular, intervals.
"The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.
Fatty acid derivatives that have specificity for CANNABINOID RECEPTORS. They are structurally distinct from CANNABINOIDS and were originally discovered as a group of endogenous CANNABINOID RECEPTOR AGONISTS.
Compounds that interact with and modulate the activity of CANNABINOID RECEPTORS.
An abnormal protein with unusual thermosolubility characteristics that is found in the urine of patients with MULTIPLE MYELOMA.
A subclass of cannabinoid receptor found primarily on central and peripheral NEURONS where it may play a role modulating NEUROTRANSMITTER release.
Amides composed of unsaturated aliphatic FATTY ACIDS linked with AMINES by an amide bond. They are most prominent in ASTERACEAE; PIPERACEAE; and RUTACEAE; and also found in ARISTOLOCHIACEAE; BRASSICACEAE; CONVOLVULACEAE; EUPHORBIACEAE; MENISPERMACEAE; POACEAE; and SOLANACEAE. They are recognized by their pungent taste and for causing numbing and salivation.

Specific and sensitive assay for alkaline and neutral ceramidases involving C12-NBD-ceramide. (1/19)

A fluorescent analogue of ceramide, C12-NBD-ceramide, was found to be hydrolyzed much faster than 14C-labeled ceramide by alkaline ceramidase from Pseudomonas aeruginosa and neutral ceramidase from mouse liver, while this substrate was relatively resistant to acid ceramidase from plasma of the horseshoe crab. The radioactive substrate was used more preferentially by the acid ceramidase. It should be noted that C6-NBD-ceramide, which is usually used for ceramidase assays, was hardly hydrolyzed by any of the enzymes examined, compared to C12-NBD-ceramide. For the alkaline and neutral enzymes, the Vmax and k (Vmax/Km) with C12-NBD-ceramide were much higher than those with 14C-ceramide. In contrast, for the acid enzyme these parameters with C12-NBD-ceramide were less than half those with the radioisotope-labeled substrate. It is noteworthy that the labeling of ceramide with NBD did not itself reduce the Km of the alkaline enzyme, but did that of the neutral enzyme. It was also found that C12-NBD-ceramide was preferentially hydrolyzed by the alkaline and neutral enzymes, but not the acid one, in several mammalian cell lines. This study clearly shows that the attachment of NBD, but not dansyl, increases the susceptibility of ceramide to alkaline and neutral enzyme, and decreases that to acid enzymes. Thus the use of this substrate provides a specific and sensitive assay for alkaline and neutral ceramidases.  (+info)

Molecular cloning, sequencing, and expression of the gene encoding alkaline ceramidase from Pseudomonas aeruginosa. Cloning of a ceramidase homologue from Mycobacterium tuberculosis. (2/19)

We previously reported the purification and characterization of a novel type of alkaline ceramidase from Pseudomonas aeruginosa strain AN17 (Okino, N., Tani, M., Imayama, S., and Ito, M. (1998) J. Biol. Chem. 273, 14368-14373). Here, we report the molecular cloning, sequencing, and expression of the gene encoding the ceramidase of this strain. Specific oligonucleotide primers were synthesized using the peptide sequences of the purified ceramidase obtained by digestion with lysylendopeptidase and used for polymerase chain reaction. DNA fragments thus amplified were used as probes to clone the gene encoding the ceramidase from a genomic library of strain AN17. The open reading frame of 2,010 nucleotides encoded a polypeptide of 670 amino acids including a signal sequence of 24 residues, 64 residues of which matched the amino acid sequence determined for the purified enzyme. The molecular weight of the mature enzyme was estimated to be 70,767 from the deduced amino acid sequence. Expression of the ceramidase gene in Escherichia coli, resulted in production of a soluble enzyme with the identical N-terminal amino acid sequence. Recombinant ceramidase was purified to homogeneity from the lysate of E. coli cells and confirmed to be identical to the Pseudomonas enzyme in its specificity and other enzymatic properties. No significant sequence similarities were found in other known functional proteins including human acid ceramidase. However, we found a sequence homologous to the ceramidase in hypothetical proteins encoded in Mycobacterium tuberculosis, Dictyostelium discoideum, and Arabidopsis thaliana. The homologue of the ceramidase gene was thus cloned from an M. tuberculosis cosmid and expressed in E. coli, and the gene was demonstrated to encode an alkaline ceramidase. This is the first report for the cloning of an alkaline ceramidase.  (+info)

Purification and characterization of a neutral ceramidase from mouse liver. A single protein catalyzes the reversible reaction in which ceramide is both hydrolyzed and synthesized. (3/19)

We report here a novel ceramidase that was purified more than 150, 000-fold from the membrane fraction of mouse liver. The enzyme was a monomeric polypeptide having a molecular mass of 94 kDa and was highly glycosylated with N-glycans. The amino acid sequence of a fragment obtained from the purified enzyme was homologous to those deduced from the genes encoding an alkaline ceramidase of Pseudomonas aeruginosa and a hypotheical protein of the slime mold Dictyostelium discoideum. However, no significant sequence similarities were found in other known functional proteins including acid ceramidases of humans and mice. The enzyme hydrolyzed various N-acylsphingosines but not galactosylceramide, sulfatide, GM1a, or sphingomyelin. The enzyme exhibited the highest activity around pH 7.5 and was thus identified as a type of neutral ceramidase. The apparent K(m) and V(max) values for C12-4-nitrobenzo-2-oxa-1, 3-diazole-ceramide and C16-(14)C-ceramide were 22.3 microM and 29.1 micromol/min/mg and 72.4 microM and 3.6 micromol/min/mg, respectively. This study also clearly demonstrated that the purified 94-kDa ceramidase catalyzed the condensation of fatty acid to sphingosine to generate ceramide, but did not catalyze acyl-CoA-dependent acyl-transfer reaction.  (+info)

Cloning and characterization of a novel human alkaline ceramidase. A mammalian enzyme that hydrolyzes phytoceramide. (4/19)

Ceramidases are enzymes involved in regulating cellular levels of ceramides, sphingoid bases, and their phosphates. Based on sequence homology to the yeast alkaline ceramidases YPC1p (Mao, C., Xu, R., Bielawska, A., and Obeid, L. M. (2000) J. Biol. Chem. 275, 6876--6884) and YDC1p (Mao, C., Xu, R., Bielawska, A., Szulc, Z. M., and Obeid, L. M. (2000) J. Biol Chem. 275, 31369--31378), we report the identification and cloning of a cDNA encoding for a novel human alkaline ceramidase (aPHC) that hydrolyzes phytoceramide selectively. Northern blot analysis showed that aPHC was ubiquitously expressed, with the highest expression in placenta. Green fluorescent protein tagging showed that it was localized in both the Golgi apparatus and endoplasmic reticulum. Overexpression of aPHC in mammalian cells elevated in vitro ceramidase activity toward N-4-nitrobenz-2-oxa-1,3-diazole-C(12)-phytoceramide. Its expression in a yeast mutant strain devoid of any ceramidase activity restored the ceramidase activity and caused an increase in the hydrolysis of phytoceramide in yeast cells, thus leading to the decreased biosynthesis of sphingolipids. These data collectively suggest that, similar to the yeast phytoceramidase YPC1p, aPHC has phytoceramidase activity both in vitro and in cells; hence, it is a functional homolog of the yeast phytoceramidase YPC1p. However, in contrast to YPC1p, aPHC exhibited no reverse activity of ceramidase either in vitro or in cells. Biochemical characterization showed that aPHC had a pH optimum of 9.5, was activated by Ca(2+), but was inhibited by Zn(2+) and sphingosine. Substrate specificity showed that aPHC hydrolyzed phytoceramide preferentially. Together, these data demonstrate that aPHC is a novel human alkaline phytoceramidase, the first mammalian alkaline ceramidase to be identified as being specific for the hydrolysis of phytoceramide.  (+info)

Cloning and characterization of a mouse endoplasmic reticulum alkaline ceramidase: an enzyme that preferentially regulates metabolism of very long chain ceramides. (5/19)

Ceramidases deacylate ceramides, important intermediates in the metabolic pathway of sphingolipids. In this study, we report the cloning and characterization of a novel mouse alkaline ceramidase (maCER1) with a highly restricted substrate specificity. maCER1 consists of 287 amino acids, and it has a 28 and 32% identity to the Saccharomyces alkaline ceramidases (YPC1p and YDC1p) and the human alkaline phytoceramidase, respectively. Reverse transcriptase-PCR analysis demonstrated that maCER1 was predominantly expressed in skin. maCER1 was localized to the endoplasmic reticulum as revealed by immunocytochemistry. In vitro biochemical characterization determined that maCER1 hydrolyzed D-erythro-ceramide exclusively but not D-erythro-dihydroceramide or D-ribo-phytoceramide. Similar to other alkaline ceramidases, maCER1 had an alkaline pH optimum of 8.0, and it was activated by Ca2+ but inhibited by Zn2+,Cu2+, and Mn2+. maCER1 was also inhibited by sphingosine, one of its products. Metabolic labeling studies showed that overexpression of maCER1 caused a decrease in the incorporation of radiolabeled dihydrosphingosine into ceramide and complex sphingolipids but led to a concomitant increase in sphingosine-1-P (S1P) in HeLa cells. Mass measurement showed that overexpression of maCER1 selectively lowered the cellular levels of D-erythro-C24:1-ceramide, but not other ceramide species and caused an increase in the levels of S1P. Taken together, these data suggest that maCER1 is a novel alkaline ceramidase with a stringent substrate specificity and that maCER1 is selectively expressed in skin and may have a role in regulating the levels of bioactive lipids ceramide and S1P, as well as complex sphingolipids.  (+info)

Golgi alkaline ceramidase regulates cell proliferation and survival by controlling levels of sphingosine and S1P. (6/19)

Sphingosine-1-phosphate (S1P), a sphingolipid metabolite, promotes cell proliferation and survival whereas its precursor, sphingosine, has the opposite effects. However, much remains unknown about their regulation. Here we identify a novel human ceramidase (haCER2) that regulates the levels of both sphingosine and S1P by controlling the hydrolysis of ceramides. haCER2 is localized to the Golgi complex and is highly expressed in the placenta. High ectopic expression of haCER2 caused fragmentation of the Golgi complex and growth arrest in HeLa cells due to sphingosine accumulation. Low ectopic expression of haCER2 increased S1P without sphingosine accumulation, promoting cell proliferation in serum-free medium. This proliferative effect was suppressed by dimethylsphingosine, an inhibitor of the S1P formation, or by the RNA interference (RNAi) -mediated inhibition of S1P(1,) a G-protein-coupled receptor for S1P. The RNAi-mediated down-regulation of haCER2 enhanced the serum deprivation-induced growth arrest and apoptosis of HeLa cells, which was inhibited by addition of exogenous S1P. Serum deprivation up-regulated both haCER2 mRNA and activity in HeLa cells. haCER2 mRNA is also up-regulated in some tumors. Taken together, these results suggest that haCER2 is important for the generation of S1P and S1P-mediated cell proliferation and survival, but that its overexpression may cause cell growth arrest due to an accumulation of sphingosine.  (+info)

Upregulation of the human alkaline ceramidase 1 and acid ceramidase mediates calcium-induced differentiation of epidermal keratinocytes. (7/19)

Extracellular calcium (Ca2+(o)) potently induces the growth arrest and differentiation of human epidermal keratinocytes (HEKs). We report that Ca2+(o) markedly upregulates the human alkaline ceramidase 1 (haCER1) in HEKs; and its upregulation mediates the Ca2+(o)-induced growth arrest and differentiation of HEKs. haCER1 is the human ortholog of mouse alkaline ceramidase 1 that we previously identified. haCER1 catalyzed the hydrolysis of very long-chain ceramides to generate sphingosine (SPH). This in vitro activity required Ca2+. Ectopic expression of haCER1 in HEKs decreased the levels of D-e-C(24:1)-ceramide and D-e-C(24:0)-ceramide but elevated the levels of both SPH and its phosphate (S1P), whereas RNA interference-mediated knockdown of haCER1 caused the opposite effects on the levels of these sphingolipids in HEKs. Similar to haCER1 overexpression, Ca2+(o) increased the levels of SPH and S1P, and this was attenuated by haCER1 knockdown. haCER1 knockdown also inhibited the Ca2+(o)-induced growth arrest of HEKs and the Ca2+(o)-induced expression of keratin 1 and involucrin in HEKs. In addition, the acid ceramidase (AC) was also upregulated by Ca2+(o); and its knockdown attenuated the Ca2+(o)-induced expression of keratin 1 and involucrin in HEKs. These results strongly suggest that upregulation of haCER1 and AC mediates the Ca2+(o)-induced growth arrest and differentiation of HEKs by generating SPH and S1P.  (+info)

Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and sphingosine-1-phosphate. (8/19)

 (+info)

K00654 SPT; serine palmitoyltransferase [EC:2.3.1.50] K00654 SPT; serine palmitoyltransferase [EC:2.3.1.50] K00654 SPT; serine palmitoyltransferase [EC:2.3.1.50] K04708 E1.1.1.102; 3-dehydrosphinganine reductase [EC:1.1.1.102] K04710 CERS; ceramide synthetase [EC:2.3.1.24] K04710 CERS; ceramide synthetase [EC:2.3.1.24] K04710 CERS; ceramide synthetase [EC:2.3.1.24] K04710 CERS; ceramide synthetase [EC:2.3.1.24] K04710 CERS; ceramide synthetase [EC:2.3.1.24] K04710 CERS; ceramide synthetase [EC:2.3.1.24] K12348 ASAH1; acid ceramidase [EC:3.5.1.23] K12349 ASAH2; neutral ceramidase [EC:3.5.1.23] K01441 ACER1_2; alkaline ceramidase [EC:3.5.1.23] K01441 ACER1_2; alkaline ceramidase [EC:3.5.1.23] K04711 ACER3; dihydroceramidase [EC:3.5.1.-] K04712 DEGS; sphingolipid 4-desaturase/C4-monooxygenase [EC:1.14.19.17 1.14.18.5] K04712 DEGS; sphingolipid 4-desaturase/C4-monooxygenase [EC:1.14.19.17 1.14.18.5] K04714 SGMS; shingomyelin synthase [EC:2.7.8.27] K04714 SGMS; shingomyelin synthase [EC:2.7.8.27] ...
The epidermis is the outermost layer of skin that acts as a barrier to protect the body from the external environment and to control water and heat loss. This barrier function is established through the multistage differentiation of keratinocytes and the presence of bioactive sphingolipids such as c …
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Erika Espinoza of Free Hoop is sharing this useful little tutorial for all of our Spanish-speaking hoopers out there who want to give it a go and make their own hula hoop! Her recommendations for materials are mostly stuff you can get at your local hardware store and you need no more than your kitchen and some space to make it all happen. So go for it and try making your own hula! Erika lives Monterrey, Nuevo Leon, Mexico.. Erika Espinoza de Free Hoop nos comparte este pequeño tutorial, super útil para todos nuestros hoopers de habla hispana que quisieran intentar hacer sus propios aros hula hula. Sus recomendaciones para los materiales son en su mayoría cosas que puedes conseguir en la ferretería o tienda de materiales más cercana. No necesitas más que tu cocina y un espacio para hacer que todo suceda. Así que, inténtalo y estamos seguros que te sentirás [email protected] de hacer tu propia hula. Erika vive Monterrey, Nuevo León, México.. ...
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¿Buscás algo que hacer en Grapevine? Seas residente, nuevo en la ciudad o simplemente estés de paso, tenemos un montón de sugerencias y eventos. Podés explorar por ubicación, por popularidad, por nuestras mejores selecciones, eventos gratis... lo que te parezca. ¿Listo?
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No se preocupe, el test no está medido en tiempo, así que relájese y concéntrese en las preguntas y lo hará genial. Durante la prueba, puede hacer clic en el botón Revisar pregunta para marcar la pregunta en amarillo como un recordatorio visual para volver a visitar la pregunta antes de enviar las respuestas de la prueba. Al hacer clic en el botón de una pregunta numerada, accederá directamente a esa pregunta en el cuestionario. Cuando esté seguro de haber revisado y respondido la pregunta de la mejor forma que pueda, debe hacer clic en Revisar pregunta nuevamente para eliminar el color amarillo del botón de pregunta.. Si obtiene una puntuación inferior al 100% en el cuestionario, deberá volver a tomarla hasta que obtenga una puntuación del 100% para completar la lección. Si desea volver a tomar la Prueba de inmediato, el botón Continuar en la pantalla de resumen de puntaje de la Prueba lo llevará al comienzo de la Prueba. Si obtuvo un puntaje del 100% en el cuestionario, ¡buen ...
RESUMEN. Introducci n: La artroplastia reversa es en la actualidad la artroplastia de hombro con m s indicaciones y capacidad de soluci n de problemas. De todas las artroplastias reversas de hombro (ARH) m s de 50% habr n fallado a los 10 a os. El objetivo de esta revisi n de alcance es identificar las principales problem ticas a las cuales nos enfrentamos al tener un paciente con una pr tesis reversa fallida. Material y m todos: Se realiz una revisi n de alcance del tema fallo de pr tesis reversa y revisi n de pr tesis reversa de hombro . Debido a la reciente aparici n de este tipo de problemas y a su constante cambio en el manejo, se decidi realizarla de la literatura de los ltimos cinco a os (diciembre de 2014 a noviembre de 2019). Resultados: Las principales causas de revisi n de la ARH son inestabilidad (32%), infecci n (13.8%), disociaci n del componente glenoideo (12.2%), aflojamiento glenoideo (10.4%), aflojamiento humeral (5.5%), dificultad al poner la base glenoidea (4.8%) y dificultad ...
Qué fue de Jorge Sanz?,4,¿Y tú qué miras?,1,71,5,(500) Días Juntos,4,(Now and then there´s) A fool such as I,1,@Aleyt1,1,@bgtraducciones,1,@MissMacGuffin,1,#0,3,#DobleoNada,1,#Littlesecretfilm,1,#SemanaWhovian,4,#SeQueSoySeriefiloPorque,1,007,3,007: James Bond de espía a icono,1,10 años,1,10 razones para odiarte,3,100 capítulos,3,10000 KM,9,1001 películas,1,10ª temporada,27,10º episodio,4,10x01,2,10x02,2,10x03,1,10x04,1,10x05,1,10x06,1,10x07,1,10x08,1,10x09,2,10x10,1,10x11,1,10x12,1,10x13,1,10x14,1,10x15,1,10x16,1,10x17,1,10x18,1,10x19,1,10x20,1,10x21,1,10x22,1,10x23,1,11ª Temporada,9,11º episodio,3,11x01,2,11x02,1,11x03,1,11x04,1,11x05,1,11x06,1,11x07,1,11x08,1,11x09,1,11x10,1,12 años de esclavitud,23,12 Valientes,1,120 pulsaciones por minuto,1,120fps,1,12ª temporada,22,12º episodio,3,12x01,1,12x02,1,12x03,1,12x04,1,12x05,1,12x06,1,12x07,1,12x08,2,12x09,2,12x10,1,12x11,2,12x12,2,12x13,2,12x14,2,12x15,2,12x16,2,12x17,2,12x18,2,12x19,2,12x20,2,12x21,2,12x22,2,12x23,2,12x24,1,13 ...
2009/3/6 Marcelo Guzmán ,marcegl91 at gmail.com,: ,, Evitar el top-posting está entre las sugerencias, no entre las reglas. , , De hecho, no. Se obliga al user a no hacer top-posting. Ojo, eh!. Yo estoy de acuerdo con NO hacer top posting..., pero es falso que es una sugerencia, son las reglas de la lista, y como ellas mismas, deben ser respetadas. Marcelo: Acá tenés las reglas y las sugerencias. Te recomiendo que las leas: https://wiki.ubuntu.com/ArgentinaTeam/EtiquetaML Idem para el compañero Hugo Valencia. No seamos más estrictos que la propia etiqueta. Querámosnos. Saludos Moski ...
Publications Is it a Cold or Flu or COVID-19? ¿Es un Resfriado o Influenza o COVID-19? COVID-19 What if Ive Been Exposed ¿Qué pasa si he estado expuesto? (en Español) Social Distancing Distanciamiento Social (en Español) Social Distancing: What does it mean? Distanciamiento social: ¿qué significa? Face Coverings Dos and Donts Cubrirse la cara Qué hacer y qué no hacer
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Con 192 países miembros, INTERPOL es la mayor organización policial internacional del mundo. Nuestra función es permitir que las policías de todo el planeta colaboren para hacer del mundo un lugar más seguro. Nuestra moderna infraestructura de apoyo técnico y operativo contribuye a hacer frente a las crecientes dificultades que comporta la lucha contra la delincuencia en el siglo XXI.. ...
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Hoy por fin despues de muchos dias, me puse a hacer tarjetas para mi tienda, la mayoria fueron hechas con colores alucivos a la primavera que ya esta a la vuelta de la esquina, aunque aqui en pa. aun tenemos 2 pies de nieve y esta muy frio pero bueno, llegara cuando menos nos lo esperemos. Por cierto estoy muy emocionada utlizando mi nueva herramienta de calor con la que puedo hacer el relieve de los sellos... me encanta ...
Dark_Ryoga : Encontre por fin tonos polifonicos para hacer con tu celular ! ya ke no me los puedo bajar de internet, me los puedo hacer son... : Offtopic
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Pagina dedicada a los peque os artistas. Que les gusta escribir, dibujar, hacer webs, videos, fanarts, fanfics... Aqu subir n sus trabajos online directamente y tendr n su propia galer a. a qu esperas?
Pagina dedicada a los peque os artistas. Que les gusta escribir, dibujar, hacer webs, videos, fanarts, fanfics... Aqu subir n sus trabajos online directamente y tendr n su propia galer a. a qu esperas?
Arkadaşlar sayfamız için bilimsel haberleri İngilizceden Türkçeye çevirecek gönüllü tercümanlar arıyoruz. İletişim için [email protected] adresine mail atmanız yeterli. Gönüllü arkadaşlarımızı bizimle yol almaya bekliyoruz. Sevgiler… ...
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Music video by Sethler performing Qué Vas a Hacer. (P) 2013 The copyright in this sound recording is owned by Hugo Martín Cuervo under exclusive licence to EMI Music Spain, S.L.. Watch it on Contactmusic.com.
Cuando una persona es adolescente comienza a estar más consciente de lo que piensan otras personas. Parece haber algo correcto que ponerse, o decir, o hacer. También parecen estar las cosas que no se deben hacer; cosas que podrían ser vergonzosas, o que lo harán perder puntos con los amigos.. La idea de que las personas puedan estar prestando atención particular a lo que hacen, pone a muchos niños ansiosos; algunos están tan ansiosos que desarrollan algo que se llama trastorno de ansiedad social. Es cuando una persona se preocupa tanto acerca de lo que le parece a otras personas que deja de hacer las cosas que necesita (y desea hacer) por el miedo a avergonzarse a sí mismo.. La mayoría de las personas con el trastorno comienza a notar esta ansiedad cuando están en edades entre 8 y 15 años. Durante un tiempo, los niños usualmente son capaces de ocultarlo. Sus padres y maestros podrían no notar que haya algo malo, especialmente debido a que los niños con frecuencia se sienten ...
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Empezé a elegir lo que me gustaba, a hacer las cosas que me apetecían y no lo que debería de hacer.. Y es en estos cambios en los que estoy interesado, en que las personas elijan lo que les divierte y les hace vivos.. Era un estudiante normal a pesar de que no entendía mucho el por qué estudiar tantas cosas y tener unos horarios repetitivos y estructuras. Un poco aburrido.. Así que entre esa rebeldia y curiosidad para descubrir otras formas de vivir, me di cuenta que quería dedicar mi vida a hacer lo que me guste.. Y veo que eso crea un mundo mejor para mi y para otras personas, cuando uno elije lo que le funciona, se respeta y así puede respetar las elecciones de los otros, con lo cual se crea más facilidad para el mundo y una realidad más grandiosa.. Y encontrar Access ha sido un regalo immenso para que esto sea posible. Para tener más de mí. Conocer mucho más de mi y abrirme a recibir y crear mucho más en esta vida en este planeta. Agradezco a Access Consciuosness y sus ...
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After a 15-target Week 16 last year in which Jeudy had only six catches and several egregious drops, he exploded for 7-5-140-1 in Week 17, including a spectacular 92-yard catch-and-run TD, showing why he was the second wide receiver taken in the 2020 draft. All told, Jeudy had 13 drops, one of the highest totals in recent memory (though mercifully eclipsed by Diontae Johnsons 15) and pedestrian per-play output (7.6 YPC). On the bright side, he showed he could stretch the field with 16.5 YPC (2nd) and four catches for 40-plus yards on only 113 targets. At 6-1, 193, and running a 4.45 40, Jeudy is a smooth route runner, unusually polished for his age. And he seems to play faster in pads. The problems for Jeudy, aside from the drops, are poor QB play and competition for targets. Teddy Bridgewater will be the Week 1 starter, with Drew Lock available in reserve. Courtland Sutton, a rising star in his own right, should be back from a torn ACL, while Tim Patrick, the biggest and most efficient Broncos ...
La clave para perder peso es hacer cambios peque os todos los d as. Esto ayuda a establecer h bitos saludables y duraderos. Las dietas que prometen ayudarte a perder peso r pido no son saludables y pueden hacer que subas de peso ...
Mala tekst. O mala gledaj kom si srce dala taj ti nikad nece reci hvala. Slusaj rasta coby mala. Baby dime qué tengo que hacer he said mi nena tú ere. Tekst pjesme jelena karleusa mala. Mala tekst zana. Mala voli audi mala voli bmw mala voli dolare mala voli evre penje se na stolove voli separe nemoj biti siguran da mala voli tebe x2 ona mi u klubu deluje baš tako da ni jednu drugu nikad ne bih tako naručila je turu popiće je lako. Da li ona zna ma da li ona zna ma da li ona zna koliko sam starija da bi bila kao ja trebace jos ovoliko do tada cao cao mala ti si niko. 2x ta mala treba jos da uci mala jos si mlada. Ma da li ona zna ma da li ona zna ma da li ona zna da li zna ko sam ja ma pusti tu malu kuci neka ceka sta ti to treba kad znas da sam broj jedan. Anuel anuel real hasta la muerte baby uah qué tengo que hacer pa que tú sea mi mujer. Lyrics tekst pjesme dodaj ili ispravi tekst. Ti sa takvim grudima ti sa takvim ocima mogla si da imas svet ceo svet pod nogama. ...
GLFHC is currently vaccinating adolescents 12 years of age and older for the COVID19 vaccine. To schedule an appointment, please click more info button or call our COVID vaccine call center at 978-686-6029 to schedule an appointment.. GLFHC está vacunando a adolescentes de 12 años o más para la vacuna de COVID -19. Para hacer una cita, haga clic en el botón more info o llame a nuestro centro de llamadas de vacunas al 978-686-6029 para hacer una cita.. ...
Ingredientes. 1 litro de leche entera. 1 1/4 taza de azùcar. 1 cucharadita de vainilla. 4 huevos grandes. pizca de sal. 150 grs. de Dulce de Leche. En muchos paìse no hay Dulce de Leche y para los que no lo sepan preparar encontrè una receta muy buena en un Blog de Lauriels kitchen que dice asì:. Para hacer dulce de leche en casa retire primero las etique. tas de los tarros de leche condensada azucarada. (se pueden hacer dos o tres por vez, y se guardan....si es que pueden) Coloque los tarros sin abrir en una olla grande y coloque suficeinte agua para cubrirlos. 1 o 2 pulgadas. Pongalos a hervir con agua hasta que hiervan a fuego fuerte, entonces baje el calor a fuego medio, tàpelos y dèjelos cocer por 2 horas aprox., agregue màs agua si es neceario y tenga cuidado que nunca queden sin agua los tarros y que estèn completamente cubiertos. Despues cuando esten listos dèjelos enfriar a temperatura ambiente (o se pueden colocar en agua frìa) pero hay que dejarlos enfriar bien antes de ...
Answer YES (Si) or NO (Circle/Circule). Yes or No: I have to struggle to finish jobs (Tengo que luchar para terminar los trabajos). Yes or No: I feel a strong need to sleep during the day (Me siento una fuerte necesidad de dormir durante el día). Yes or No: I often feel lonely even when I am with other people (Me siento solo aunque este con otras personas). Yes or No: I have to read things several times before they sink in (Leo las cosas varias veces antes de memorizar las). Yes or No: Its difficult for me to make friends (Es difícil para mí hacer amigos). Yes or No: It takes a lot of effort for me to do simple tasks (Me toma mucho esfuerzo para hacer labores simples). Yes or No: I have difficulty controlling my emotions (Tengo dificultad para controlar mis emociones). Yes or No: I often lose track of what I want to say (Muchas veces pierdo la noción de lo que quiero decir). Yes or No: I lack confidence (No tengo confianza en mí). Yes or No: I have to push myself to do things (Tengo que ...
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In some countries, you might find that the Women on Web website is censored. Here you can read about several ways you… Read more » ...
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De gusto a uno de sus allegados ofreciéndole esta tarjeta regalo. Usted puede dársela en mano o hacer que se la envíen directamente. Voir le fonctionnement en détail (Instructions en Français :
El estrés del día a día puede causar pérdida de concentración y disminución de la libido, interfiriendo en el rendimiento masculino. No lo voy a hacer desde el lado médico por que no lo soy, tampoco soy químico.. ...
Somos una agencia de Branded Entertainment Marketing con más de 23 años de recorrido en la gestión del talento, eventos y estrategia. Trabajamos campañas con influencers y queremos hacer más ágil el proceso de gestión entre influencer - Thinketers - cliente, con beneficios para todos ...
¿Buscas algo que hacer en Stockton-On-Tees? Tanto si eres del lugar, recién llegado o estás de paso, tenemos montones de sugerencias y eventos estupendos para que los explores. ¿Listo?
Busqué en Google y no encuentro la mencionada campaña de La Comunidad. Acostumbro seguir de cerca la mayoría de los festivales y no la recuerdo (posiblemente mi memoria no alcance a 5 años), de cualquier manera P&M es una revista de marketing, no mucho que ver con la discriminación, ¿no?. Son 5 Directores Generales Creativos, y un Director Creativo. La idea surgió durante el cambio entre la gestión de Alvar Suñol y Manuel Techera a la gestión actual. En JWT México, aunque el departamente creativo es muy grande, los cuatro VPs se involucran a fondo para hacer crecer las ideas, por eso merecen su crédito. Acerca del para esto??? pues tienes derecho a tu opinión.. ...
Como hay tantos análisis de como ha ido el E3, aquí os dejo este vídeo. Lo que puede hacer el aburrimiento y un montón de botellas.
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The man fell from his chair seizing existence, seizing into the arms of a man in the center of Los Lobos, seizing lightly to the ground, seizing for what seemed to be an eternal moment. His hands frozen in time, locked in a shiver, as if trying to grasp light, or air. He was molested in a sense, first the man wanted to remove him from the vicinity. I quickly interrupted, No puedes hacer nada! Shortly after a man who worked there approached easily placing a spoon in his mouth, followed by a cloth dampened with alcohol under his nose. I felt for the victim as the taste of cold metal and fumes penetrated his brain. He could not resist either of the two and he shook as if his blood was bound by hypothermia. I could see the desire to fight in the depths of his eyes. He lay like a freshly branded calf, tired, tied, pinned by pain, forcibly receiving that of which at any other moment he would have rejected with a swift kick. His ears may as well have been notched with a knife and tagged with a red ...
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Alkaline ceramidase 3 also known as ACER3 is a ceramidase enzyme which in humans is encoded by the ACER3 gene. GRCh38: Ensembl ... "Cloning and characterization of a novel human alkaline ceramidase. A mammalian enzyme that hydrolyzes phytoceramide". J. Biol. ... Mao C, Obeid LM (September 2008). "Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and ...
Alkaline ceramidase 2 also known as ACER2 is a ceramidase enzyme which in humans is encoded by the ACER2 gene. The ACER2/ ... Sun W, Hu W, Xu R, Jin J, Szulc ZM, Zhang G, Galadari SH, Obeid LM, Mao C (February 2009). "Alkaline ceramidase 2 regulates ... 2006). "Golgi alkaline ceramidase regulates cell proliferation and survival by controlling levels of sphingosine and S1P". ... Mao C, Obeid LM (September 2008). "Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and ...
"Human meconium contains significant amounts of alkaline sphingomyelinase, neutral ceramidase, and sphingolipid metabolites". ... and named alkaline sphingomyelinase (alk-SMase), as the optimal pH of the enzyme was 9.0 and its main substrate is ... 2005). "Cloning of alkaline sphingomyelinase from rat intestinal mucosa and adjusting of the hypothetical protein XP_221184 in ... Andersson D, Kotarsky K, Wu J, Agace W, Duan RD (July 2009). "Expression of alkaline sphingomyelinase in yeast cells and anti- ...
2006). "Golgi alkaline ceramidase regulates cell proliferation and survival by controlling levels of sphingosine and S1P". ... A novel but highly conserved gene family of neutral/alkaline ceramidases". J. Biol. Chem. 275 (15): 11229-34. doi:10.1074/jbc. ... Neutral ceramidase is an enzyme that in humans is encoded by the ASAH2 gene. GRCh38: Ensembl release 89: ENSG00000188611 - ... 2004). "Neutral ceramidase gene: role in regulating ceramide-induced apoptosis". Gene. 315: 113-22. doi:10.1016/S0378-1119(03) ...
2006). "Golgi alkaline ceramidase regulates cell proliferation and survival by controlling levels of sphingosine and S1P". ... Sphingosine (Sph) is formed by the action of ceramidase (CDase) enzymes on ceramide in the lysosome. Sph can also be formed in ... The low levels of Sph and their increase in response to stimulation of cells, primarily by activation of ceramidase by growth- ... Ceramide can also be broken down by enzymes called ceramidases, leading to the formation of sphingosine, Moreover, a phosphate ...
Alkaline ceramidase 1 also known as ACER1 is a ceramidase enzyme which in humans is encoded by the ACER1 gene. ACER1 mediates ... "Upregulation of the human alkaline ceramidase 1 and acid ceramidase mediates calcium-induced differentiation of epidermal ... "Cloning and characterization of a mouse endoplasmic reticulum alkaline ceramidase: an enzyme that preferentially regulates ... Ito M, Okino N, Tani M, Mitsutake S, Mori K (Mar 2002). "[Molecular evolution of neutral ceramidase: signalling molecule and ...
... alkaline ceramidase 1) This disambiguation page lists articles associated with the same title formed as a letter-number ...
... cell survival neutral ceramidase (ASAH2, ASAH2B, ASAH2C) - protective against inflammatory cytokines alkaline ceramidase 1 ( ... Presently, 7 human ceramidases encoded by 7 distinct genes have been cloned: acid ceramidase (ASAH1) - ... mediating cell differentiation by controlling the generation of SPH and S1P alkaline ceramidase 2 (ACER2) - important for cell ... Human neutral ceramidase (nCDase) is an enzyme that plays a critical role in colon cancer and there are currently no potent or ...
Aspergillus alkaline proteinase. Now EC 3.4.21.63, oryzin EC 3.4.21.16: Deleted entry: Alternaria serine proteinase EC 3.4. ... ceramidase EC 3.5.1.24: choloylglycine hydrolase EC 3.5.1.25: N-acetylglucosamine-6-phosphate deacetylase EC 3.5.1.26: N4-(beta ... alkaline phosphatase EC 3.1.3.2: acid phosphatase EC 3.1.3.3: phosphoserine phosphatase EC 3.1.3.4: phosphatidate phosphatase ...
Alkaline ceramidase YPC1Add BLAST. 316. Proteomic databases. PaxDb, a database of protein abundance averages across all three ... Alkaline ceramidase YPC1 (EC:3.5.1.-*Search proteins in UniProtKB for this EC number. ... "Characterization of yeast mutants lacking alkaline ceramidases YPC1 and YDC1.". Voynova N.S., Mallela S.K., Vazquez H.M., ... Belongs to the alkaline ceramidase family.Curated. Keywords - Domaini. Transmembrane, Transmembrane helix. Phylogenomic ...
... J Pathol. 2016 ... Here we reveal the essential role of alkaline ceramidase 1 (Acer1) in the skin. Acer1-deficient (Acer1(-/-) ) mice showed ... the levels of which are tightly regulated by a balance of ceramide synthase and ceramidase activities. ...
Mouse Alkaline ceramidase 1 (ACER1) ELISA Kit-NP_597999.1 (MBS7235867) product datasheet at MyBioSource, ELISA Kits ... alkaline ceramidase 1; alkCDase 1; alkaline CDase 1; acylsphingosine deacylase 3; N-acylsphingosine amidohydrolase 3; N- ... ACER1 elisa kit :: Mouse Alkaline ceramidase 1 (ACER1) ELISA Kit. Catalog #. MBS7235867 .mycenter { display: block; margin-left ... Belongs to the alkaline ceramidase family.. Protein type: Hydrolase; Lipid Metabolism - sphingolipid; EC 3.5.1.23; Endoplasmic ...
ACER2; alkaline ceramidase 2; ASAH3L, N acylsphingosine amidohydrolase 3 like; FLJ41587; haCER2; alkCDase 2; alkaline CDase 2; ... The ceramidase ACER2 hydrolyzes very long chain ceramides to generate;sphingosine (Xu et al., 2006 (PubMed 16940153)). ...
Alkaline ceramidase 2 is the one ceramidase that has been found essential for the generation of normal levels of sphingosine in ... Alkaline ceramidase 2 is the one ceramidase that has been found essential for the generation of normal levels of sphingosine in ... Alkaline ceramidase 2 (ACER2) is the one ceramidase that has been found essential for the generation of normal levels of ... Alkaline ceramidase 2 is essential for the homeostasis of plasma sphingoid bases and their phosphates. FASEB J 32(6):3058-3069 ...
alkaline ceramidase 1 MGI:2181962 .yui-skin-sam .yui-dt th{ background:url(http://www.informatics.jax.org/webshare/images/cre/ ...
Expression of Intestinal and Lung Alkaline Sphingomyelinase and Neutral Ceramidase in Cystic Fibrosis F508del Transgenic Mice. ...
ceramidase;. acylsphingosine deacylase;. glycosphingolipid ceramide deacylase. Class. Hydrolases;. Acting on carbon-nitrogen ...
Several canonical genes encoding ceramide synthase (encoded by PcLAG1 and PcLAF1), alkaline ceramidase (PcYXC1) and ...
Cloning and characterization of a mouse endoplasmic reticulum alkaline ceramidase: an enzyme that preferentially regulates ... Cloning and characterization of a novel human alkaline ceramidase. A mammalian enzyme that hydrolyzes phytoceramide. ...
340485 ACER2; alkaline ceramidase 2 125981 ACER1; alkaline ceramidase 1 55331 ACER3; alkaline ceramidase 3 8560 DEGS1; delta 4- ... neutral ceramidase [EC:3.5.1.23] K01441 ACER1_2; alkaline ceramidase [EC:3.5.1.23] K01441 ACER1_2; alkaline ceramidase [EC:3.5. ... neutral ceramidase [EC:3.5.1.23] K01441 ACER1_2; alkaline ceramidase [EC:3.5.1.23] K01441 ACER1_2; alkaline ceramidase [EC:3.5. ... 340485 ACER2; alkaline ceramidase 2 125981 ACER1; alkaline ceramidase 1 8717 TRADD; TNFRSF1A associated via death domain 7186 ...
Alkaline ceramidase 2 (Acer2) is a type of ceramidases, which are key enzymes of the degradation of intracellular ceramide and ... Acer2 (alkaline ceramidase 2) regulates the hydrolysis of ceramides. Slc38a2 (solute carrier family 38 member 2) is a sodium- ... P. W. Wertz and D. T. Downing, "Ceramidase activity in porcine epidermis," FEBS Letters, vol. 268, no. 1, pp. 110-112, 1990. ...
Human and mouse alkaline ceramidase 1 and skin diseases. May, 2006. Obeid et al. ...
Alkaline Ceramidase 2 Pseudogene 3 * AC017081.1 5 External Ids for ACER2P1 Gene. *HGNC: 54674 ...
Alkaline ceramidase 1. NM_133492. Gene Info. ACER2. Alkaline ceramidase 2. NM_001010887. Gene Info. ... Alkaline phosphatase, liver/bone/kidney. NM_000478. NM_001127501. NM_001177520. Gene Info. ...
Alkaline ceramidase 2. NM_139306. Gene Info. Acer2. Alkaline ceramidase 2. AK046888. Gene Info. ...
Ceramidase and ceramide synthesis in human kidney and cerebellum. Description of a new alkaline ceramidase. Biochim Biophys ... Effect of hypoxia on acid ceramidase (AC) RNA levels in Ewings sarcoma family of tumors cell lines and of AC inhibitor on ... The metabolic pathway for ceramides includes deacylation by alkaline, neutral, and AC (43 , 82) to generate sphingosine, which ... Ferlinz K, Kopal G, Bernardo K, et al Human acid ceramidase: processing, glycosylation, and lysosomal targeting. J Biol Chem, ...
Alkaline ceramidase 3 also known as ACER3 is a ceramidase enzyme which in humans is encoded by the ACER3 gene. GRCh38: Ensembl ... "Cloning and characterization of a novel human alkaline ceramidase. A mammalian enzyme that hydrolyzes phytoceramide". J. Biol. ... Mao C, Obeid LM (September 2008). "Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and ...
Targeting alkaline ceramidase 3 alleviates the severity of nonalcoholic steatohepatitis by reducing oxidative stress. ...
Targeting alkaline ceramidase 3 alleviates the severity of nonalcoholic steatohepatitis by reducing oxidative stress. ...
Alkaline ceramidase 2 also known as ACER2 is a ceramidase enzyme which in humans is encoded by the ACER2 gene. The ACER2/ ... Sun W, Hu W, Xu R, Jin J, Szulc ZM, Zhang G, Galadari SH, Obeid LM, Mao C (February 2009). "Alkaline ceramidase 2 regulates ... 2006). "Golgi alkaline ceramidase regulates cell proliferation and survival by controlling levels of sphingosine and S1P". ... Mao C, Obeid LM (September 2008). "Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and ...
Alkaline ceramidase 2 regulates beta1 integrin maturation and cell adhesion. Sun W, Hu W, Xu R, Jin J, Szulc ZM, Zhang G, ... Correction: Alkaline Ceramidase 3 Deficiency Results in Purkinje Cell Degeneration and Cerebellar Ataxia Due to Dyshomeostasis ... Correction: Alkaline Ceramidase 3 Deficiency Results in Purkinje Cell Degeneration and Cerebellar Ataxia Due to Dyshomeostasis ... Alkaline Ceramidase 3 Deficiency Results in Purkinje Cell Degeneration and Cerebellar Ataxia Due to Dyshomeostasis of ...
alkaline ceramidase 2. protein-coding. APOA2. apolipoprotein A2. protein-coding. AADAT. aminoadipate aminotransferase. protein- ...
alkaline ceramidase 2 Assay Type: Probe Assay Design: exonic Application: Gene Expression Unique Assay ID: qHsaCEP0054485 FAM ... alkaline ceramidase 2 Assay Type: EvaGreen Application: Gene Expression Unique Assay ID: dHsaEG5011581 Info: EG; Same primer ... alkaline ceramidase 2 Assay Type: EvaGreen Application: Gene Expression Unique Assay ID: dHsaEG5024518 Info: EG; Same primer ... alkaline ceramidase 2 Assay Type: Probe Application: Gene Expression Unique Assay ID: dHsaCPE5041472 Info: FAM; Same primer ...
Alkaline ceramidase 2. Aliases:. 2410116I05Rik, Asah3l, CRG-L1, maCER2. RefSeq:. NC_000070.6 NT_187032.1. ...
Alkaline ceramidases (ACER). *Alkylation repair homologs (ALKB). *Aminoacyl tRNA synthetases *Aminoacyl tRNA synthetases, Class ...
Tumor suppressor p53 links ceramide metabolism to DNA damage response through alkaline ceramidase 2 *Ruijuan Xu ... permissionsfor article Tumor suppressor p53 links ceramide metabolism to DNA damage response through alkaline ceramidase 2 . ... AKT as a key target for growth promoting functions of neutral ceramidase in colon cancer cells *Nicolas Coant ... Rights & permissionsfor article AKT as a key target for growth promoting functions of neutral ceramidase in colon cancer cells ...
Nonlysosomal ceramidase Ceramidase (CDase) is an enzyme that hydrolyzes the N-acyl linkage between a fatty acid and a sphingoid ... and expression of the gene encoding alkaline ceramidase from Pseudomonas aeruginosa. Cloning of a ceramidase homologue from ... A novel but highly conserved gene family of neutral/alkaline ceramidases. J Biol Chem. 2000b;275:11229-34.CrossRefPubMedGoogle ... Tani M., Ito M. (2018) Neutral Ceramidase. In: Choi S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. * .RIS Papers ...
Momoi, T.; Ben-Yoseph, Y.; Nadler, H.L. Substrate-specificities of acid and alkaline ceramidases in fibroblasts from patients ... Tumor suppressor p53 links ceramide metabolism to DNA damage response through alkaline ceramidase 2. Cell Death Differ. 2017, 1 ... Acid ceramidase and its inhibitors: A de novo drug target and a new class of drugs for killing glioblastoma cancer stem cells ... Proksch, D.; Klein, J.J.; Arenz, C. Potent inhibition of Acid ceramidase by novel B-13 analogues. J. Lipids 2011, 2011, 971618 ...
  • The ceramidase ACER2 hydrolyzes very long chain ceramides to generate;sphingosine (Xu et al. (creative-biogene.com)
  • Our long-term goal is to define the mechanisms by which anti-cancer chemotherapeutic agents (ACCAs) induce anti-proliferative responses (proliferation inhibition and programmed cell death) in tumor cells by focusing on human alkaline ceramidase 2 (ACER2) and its lipid substrate (ceramide) and product (sphingosine). (grantome.com)
  • In contrast, our preliminary studies show that increasing the conversion of ceramide to SPH by the Golgi alkaline ceramidase 2 (ACER2) markedly enhances the cytotoxicity of doxorubicin, a known ceramide-inducing ACCA, in HeLa cells, whereas knocking down ACER2 has the opposite effect. (grantome.com)
  • The PI's group has identified a human enzyme called alkaline ceramidase 2 (ACER2) responsible for the generation of SPH from ceramide in tumor cells. (grantome.com)
  • TIM interacted with specificity protein 1 (Sp1) which contributes to upregulate the expression of alkaline ceramidase 2 (ACER2). (bvsalud.org)
  • SMases are distinguished according to their subcellular location and optimal pH for activity: SMases are named based on the pH at which they are active, with acid SMase in the lysosome, neutral SMase at the plasma membrane, and alkaline SMase in the endoplasmic reticulum [ 5 , 6 ]. (mdpi.com)
  • Structural basis for ceramide recognition and hydrolysis by human neutral ceramidase. (springer.com)
  • Role of neutral ceramidase in colon cancer. (springer.com)
  • Ito M, Okino N, Tani M. New insight into the structure, reaction mechanism, and biological functions of neutral ceramidase. (springer.com)
  • Neutral ceramidase encoded by the Asah2 gene is essential for the intestinal degradation of sphingolipids. (springer.com)
  • Essential roles of neutral ceramidase and sphingosine in mitochondrial dysfunction due to traumatic brain injury. (springer.com)
  • Okino N, Mori K, Ito M. Genomic structure and promoter analysis of the mouse neutral ceramidase gene. (springer.com)
  • Loss of neutral ceramidase increases inflammation in a mouse model of inflammatory bowel disease. (springer.com)
  • Loss of neutral ceramidase protects cells from nutrient- and energy -deprivation-induced cell death. (springer.com)
  • Tani M, Okino N, Mitsutake S, Tanigawa T, Izu H, Ito M. Purification and characterization of a neutral ceramidase from mouse liver. (springer.com)
  • Tani M, Okino N, Mori K, Tanigawa T, Izu H, Ito M. Molecular cloning of the full-length cDNA encoding mouse neutral ceramidase. (springer.com)
  • A novel but highly conserved gene family of neutral/alkaline ceramidases. (springer.com)
  • Inhibition of the neutral/alkaline ceramidase by these compounds requires around 20-fold higher concentrations. (csic.es)
  • Plasma membrane ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at neutral pH (PubMed:10781606, PubMed:16229686, PubMed:26190575). (genecards.org)
  • Three different ceramidases (acid, neutral and alkaline) have been identified and appear to play distinct roles in sphingolipid metabolism. (jle.com)
  • Alkaline sphingomyelinase (Alk-SMase) and neutral ceramidase (N-CDase) in the intestinal microvillar membrane are responsible for dietary sphingomyelin digestion. (lu.se)
  • There are three types of sphingomyelinases: magnesium-dependent acid sphingomyelinase, magnesium-independent neutral sphingomyelinase and alkaline sphingomyelinase. (biomedcentral.com)
  • Your search returned 9 neutral ceramidase ELISA ELISA Kit across 4 suppliers. (biocompare.com)
  • Increasing expression of neutral ceramidase ASAH2 on the plasma membrane also attenuates cell apoptosis induced by TNF-1, a known ceramide-generating cytokine. (grantome.com)
  • [0003] The present invention relates to a novel compound having an inhibitory activity against at least one of neutral ceramidase and alkaline ceramidase, a method for producing the novel compound, use of the novel compound, and a novel microorganism that produces the novel compound. (patentsencyclopedia.com)
  • One known cause of the aggravation is neutral/alkaline ceramidase produced by Pseudomonas aeruginosa (see, for example, Okino et al. (patentsencyclopedia.com)
  • That is, in one possible specific process through which atopic dermatitis is aggravated, ceramide of the skin of a patient with atopic dermatitis, who is infected with Pseudomonas aeruginosa in many cases, is decomposed and decreased by neutral/alkaline ceramidase produced by Pseudomonas aeruginosa, so that the barrier function of the skin is degraded. (patentsencyclopedia.com)
  • Thus, demand has arisen for developments of a new compound having an excellent inhibitory activity against neutral/alkaline ceramidase and a more effective, safe novel therapeutic drug for atopic dermatitis. (patentsencyclopedia.com)
  • Specifically, an object of the present invention is to provide a novel compound having an inhibitory activity against at least one of neutral ceramidase and alkaline ceramidase, a method for producing the novel compound, a novel microorganism that produces the novel compound, and a ceramidase inhibitor or pharmaceutical composition containing the novel compound. (patentsencyclopedia.com)
  • Once treated the surface only requires periodic cleaning with a neutral or alkaline cleaner and water. (thefreedictionary.com)
  • In the rinse, we're using a combination of an Oak alkaline cleaner and a neutral acid, which when combined cleans the part and retains the desired finish requirements. (thefreedictionary.com)
  • MBS7235867 is a ready-to-use microwell, strip plate Competitive (Quantitative) ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Alkaline ceramidase 1 (ACER1) ELISA Kit target analytes in biological samples. (mybiosource.com)
  • Alkaline ceramidase 3 also known as ACER3 is a ceramidase enzyme which in humans is encoded by the ACER3 gene. (wikipedia.org)
  • Mutation in Alkaline Ceramidase 3 ( ACER3 ) gene which encodes alkaline ceramidase enzyme that plays a crucial role in cellular growth and viability has been stated as an uncommon reason for inherited leukoencephalopathies. (biomedcentral.com)
  • ACER3 is responsible for coding the alkaline ceramidase enzyme which is responsible for the conversion of ceramide to sphingosine. (biomedcentral.com)
  • Faint abnormal white matter signals in deep and periventricular areas, thinning of corpus callosum, mild supratentorial and cerebellar atrophy, and ventriculomegaly are the imaging findings that have been reported in association with mutations in ACER3 coding alkaline ceramidase (Table 1 ). (biomedcentral.com)
  • In silico analysis of several databases of AML patients demonstrated that the expression of alkaline ceramidase 3 (ACER3) significantly inversely correlates with the overall survival of AML patients. (elsevier.com)
  • Our study indicates that ACER3 contributes to AML pathogenesis, and suggests that alkaline ceramidase inhibition is an option to treat AML. (elsevier.com)
  • Mouse alkaline ceramidase 3 (Acer3), which preferentially catalyzes the hydrolysis of C18:1-ceramide, a major unsaturated long-chain ceramide species in the brain, is upregulated with age in the mouse brain. (nih.gov)
  • Ceramidase (CDase) is an enzyme that hydrolyzes the N -acyl linkage between a fatty acid and a sphingoid base in ceramide (Cer) and is widely distributed from bacteria to mammals. (springer.com)
  • In this study, we reported that the AtACER, an alkaline ceramidase that hydrolyzes ceramide to LCB, functions in autophagy process in Arabidopsis. (readbyqxmd.com)
  • Ceramidases (EC 3.5.1.23), such as ASAH2, catalyze hydrolysis of the N-acyl linkage of ceramide, a second messenger in a variety of cellular events, to produce sphingosine. (genecards.org)
  • This coincides with the intestinal distribution of an alkaline sphingomyelinase (SMase), which may be important for digestion. (lu.se)
  • Bile diversion also decreased aminopeptidase N activity in the content and increased that in the mucosa, but had no effects on that of alkaline phosphatase. (lu.se)
  • The coding sequence for this form of alkaline phosphatase is unique in that the 3' untranslated region contains multiple copies of an Alu family repeat. (antibodies-online.com)
  • In addition, this gene is polymorphic and three common alleles (type 1, type 2 and type 3) for this form of alkaline phosphatase have been well characterized. (antibodies-online.com)
  • Cloning and characterization of a mouse endoplasmic reticulum alkaline ceramidase: an enzyme that preferentially regulates metabolism of very long chain ceramides. (harvard.edu)
  • SMA-PME is caused by mutation in the ASAH1 gene encoding acid ceramidase. (jle.com)
  • A novel alkaline SMase has been identified in human bile, with several properties similar to those of the intestinal SMase. (lu.se)
  • Effects of bile diversion in rats on intestinal sphingomyelinases and ceramidase. (lu.se)
  • There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). (antibodies-online.com)
  • Ceramidases (EC 3.5.1.23) are a group of enzymes which catalyze the hydrolysis of ceramides to produce sphingosine, which subsequently undergoes phosphorylation to generate sphingosine-1-phosphate (S1P). (genecards.org)
  • Adiponectin receptors (ADIPORs) are integral membrane proteins controlling glucose and lipid metabolism by mediating, at least in part, a cellular ceramidase activity 1 which catalyzes the hydrolysis of ceramide to produce sphingosine and a free fatty acid (FFA). (pubmedcentralcanada.ca)
  • Ceramidase catalyzes the hydrolysis of ceramide and leads to the production of sphingosine and a fatty acid. (biomedcentral.com)
  • Your search returned 15 Acid Ceramidase ELISA ELISA Kit across 3 suppliers. (biocompare.com)
  • It has recently become evident that at least five ceramidase (CDase) isoforms are present in human epidermis, and that specifically acidic CDase (aCDase) and alkaline CDase (alkCDase) activities increase during keratinocyte differentiation, and thus might play a pivotal role(s) in permeability barrier function. (tno.nl)
  • We quantified the abundances of serum ceramides and sphingosines (SPH) because adiponectin has a defined role in sphingolipid metabolism through adiponectin receptor-mediated activation of ceramidases. (frontiersin.org)
  • Cloning of an alkaline ceramidase from Saccharomyces cerevisiae. (uniprot.org)
  • Cloning and characterization of a novel human alkaline ceramidase. (harvard.edu)
  • Cloning of a ceramidase homologue from Mycobacterium tuberculosis. (springer.com)
  • Brainwashing (Bwa) is the only putative alkaline ceramidase homologue amoxicillin for cats present in Drosophila. (antibiotika365.com)
  • Because we found that ADIPOR1 also possesses an intrinsic ceramidase activity, we suspect that the two distinct structures may represent key steps of the ADIPORs enzymatic activity. (pubmedcentralcanada.ca)
  • [0007] Thus, a compound that inhibits ceramidase produced by Pseudomonas aeruginosa is expected to prevent a decrease of ceramide and hence prevent aggravation of atopic dermatitis. (patentsencyclopedia.com)
  • Furthermore, the -ketoamides 5-7 inhibit the acidic ceramidase with similar potencies (IC50 52-83 µM). (csic.es)
  • If you want to neutralize an odor or a stain but don't know its pH, try this test then use an alkaline cleaner on acidic stains and an acidic cleaner on alkaline stains. (thefreedictionary.com)
  • Substrate-specificities of acid and alkaline ceramidases in fibroblasts from patients with Farber disease and controls. (wikipathways.org)
  • Correction: Alkaline Ceramidase 3 Deficiency Results in Purkinje Cell Degeneration and Cerebellar Ataxia Due to Dyshomeostasis of Sphingolipids in the Brain. (nih.gov)
  • Several canonical genes encoding ceramide synthase (encoded by PcLAG1 and PcLAF1), alkaline ceramidase (PcYXC1) and sphingolipid C-4-hydroxylase(PcSYR2), as well as structural genes for dihydroceramide Δ(4)-desaturase (PcDES1) and sphingolipid Δ(8)-desaturase (PcSLD1) were identified, indicating that P. ciferrii would be capable of synthesizing desaturated sphingoid bases, a property not ubiquitously found in yeasts. (nih.gov)
  • an acid SMase and an alkaline ceramidase activity. (lu.se)
  • Alkaline ceramidase 2 is the one ceramidase that has been found essential for the generation of normal levels of sphingosine in the blood. (jax.org)
  • Here, we determined crystal structures of ADIPOR2 bound to a FFA molecule and demonstrate that ADIPOR2 possesses an intrinsic basal ceramidase activity enhanced by adiponectin. (pubmedcentralcanada.ca)
  • To investigate the impact of alkaline ceramidase (Dacer) on male Drosophila, we got Dacer deficiency mutants (MUs) and found they displayed apparent defects in the testis's phenotype. (bvsalud.org)
  • Biochemical characterization of the reverse activity of rat brain ceramidase. (springer.com)
  • The catabolism of ceramide in mammals occurs in lysosomes through the activity of ceramidase. (jle.com)
  • The ceramidase activity is low, however, and further studies will be required to fully characterize ADIPORs enzymatic parameters and their substrate specificity. (pubmedcentralcanada.ca)
  • Recently, the pleiotropic actions of adiponectin were linked to the ceramide signaling pathway as ADIPOR1 and ADIPOR2 activation was shown to lower ceramide levels via the activation of a ceramidase activity measured in crude cell lysates 1 . (pubmedcentralcanada.ca)
  • Ceramide can be hydrolyzed into sphingosine by ceramidases in human cells and, like ceramide, SPH can potently induce anti-proliferative effects in tumor cells both in vitro and in animal models. (grantome.com)
  • Alkaline ceramidase 2 is essential for the homeostasis of plasma sphingoid bases and their phosphates. (jax.org)