Evidence of a cyclooxygenase-related prostaglandin synthesis in coral. The allene oxide pathway is not involved in prostaglandin biosynthesis. (1/176)
Certain corals are rich natural sources of prostaglandins, the metabolic origin of which has remained undefined. By analogy with the lipoxygenase/allene oxide synthase pathway to jasmonic acid in plants, the presence of (8R)-lipoxygenase and allene oxide synthase in the coral Plexaura homomalla suggested a potential metabolic route to prostaglandins (Brash, A. R., Baertshi, S. W., Ingram, C.D., and Harris, T. M. (1987) J. Biol. Chem. 262, 15829-15839). Other evidence, from the Arctic coral Gersemia fruticosa, has indicated a cyclooxygenase intermediate in the biosynthesis (Varvas, K., Koljak, R., Jarving, I., Pehk, T., and Samel, N. (1994) Tetrahedron Lett. 35, 8267-8270). In the present study, active preparations of G. fruticosa have been used to identify both types of arachidonic acid metabolism and specific inhibitors were used to establish the enzyme type involved in the prostaglandin biosynthesis. The synthesis of prostaglandins and (11R)-hydroxyeicosatetraenoic acid was inhibited by mammalian cyclooxygenase inhibitors (indomethacin, aspirin, and tolfenamic acid), while the formation of the products of the 8-lipoxygenase/allene oxide pathway was not affected or was increased. The specific cyclooxygenase-2 inhibitor, nimesulide, did not inhibit the synthesis of prostaglandins in coral. We conclude that coral uses two parallel routes for the initial oxidation of polyenoic acids: the cyclooxygenase route, which leads to optically active prostaglandins, and the lipoxygenase/allene oxide synthase metabolism, the role of which remains to be established. An enzyme related to mammalian cyclooxygenases is the key to prostaglandin synthesis in coral. Based on our inhibitor data, the catalytic site of this evolutionary early cyclooxygenase appears to differ significantly from both known mammalian cyclooxygenases. (+info)Biosynthesis of depudecin, a metabolite of Nimbya scirpicola. (2/176)
Feeding experiments of labeled acetates to Nimbya scirpicola proved the carbon origin of the straight-chain polyketide, depudecin. Differential hydrogen exchange of the 2H label originating from 2H labeled acetate along the polyketide chain occurred. In particular, the deuterium of an epoxide methine at C-3 was lost to a substantial extent in the formation of depudecin. (+info)Female Attacus atlas respond to pheromones of Antheraea polyphemus: a comparative electrophysiological and biochemical study. (3/176)
Female Attacus atlas respond electrophysiologically to both of the Antheraea polyphemus pheromone components (E,Z)-6,11-hexadecadienyl acetate and (E,Z)-6,11-hexadecadienal. Moreover, they possess a pheromone-binding protein (PBP) and general odorant-binding proteins (GOBPs), as well as a pheromone-degrading sensillar esterase and aldehyde oxidase enzymes. They show no electroantennogram responses to their own gland extract. In contrast, female A. polyphemus do not respond to their own or to A. atlas pheromone. Male A. atlas do not detect any of the A. polyphemus compounds but only the conspecific female gland extracts. Both male A. atlas and female A. polyphemus possess PBP and GOBP but lack the pheromone-degrading esterases of male Antheraea. The results indicate that the two species use quite distinct classes of chemicals as pheromones. In spite of this, the N-terminal amino acid sequences of the PBPs show homology of 68%. (+info)Using electroactive substrates to pattern the attachment of two different cell populations. (4/176)
This report describes the development of an electroactive mask that permits the patterning of two different cell populations to a single substrate. This mask is based on a self-assembled monolayer of alkanethiolates on gold that could be switched from a state that prevents the attachment of cells to a state that promotes the integrin-mediated attachment of cells. Monolayers were patterned into regions having this electroactive monolayer and a second set of regions that were adhesive. After Swiss 3T3 fibroblasts had attached to the adhesive regions of this substrate, the second set of regions was activated electrically to permit the attachment of a second population of fibroblast cells. This method provides a general strategy for patterning the attachment of multiple cell types and will be important for studying heterotypic cell-cell interactions. (+info)Activation and inhibition of the transduction process in silkmoth olfactory receptor neurons. (5/176)
Electrophysiological responses of olfactory receptor neurons in both male and female silkmoths (Bombyx mori) were investigated. In both sexes, the G-protein activator sodium fluoride and 1,2-dioctanoyl-sn-glycerol, a membrane-permeable analog of the protein kinase C activator diacylglycerol, elicited nerve impulse responses similar to those elicited by weak continuous stimulation with odorants. Therefore, G(q)-proteins and diacylglycerol-activated ion channels seem to be involved in the transduction process in both pheromone-sensitive neurons in males and general odorant-sensitive neurons in females. Decyl-thio-trifluoro-propanone is known to inhibit electrophysiological responses of male moths to pheromones, but has no effect in females. Application of this inhibitor reduced the frequency, but not the amplitude of elementary receptor potentials. It had no inhibitory effect on nerve impulse responses elicited by sodium fluoride or 1,2-dioctanoyl-sn-glycerol. This supports the idea that decyl-thio-trifluoro-propanone acts on a prior step of the transduction cascade, e.g. on the pheromone receptor molecules. General odorants, such as (+/-)-linalool and 1-heptanol, excite olfactory receptor neurons in females, but inhibit the pheromone-sensitive neurons in males. Both (+/-)-linalool and 1-heptanol inhibited the responses of male neurons elicited by sodium fluoride or 1,2-dioctanoyl-sn-glycerol. (+/-)-Linalool reduced the amplitude of elementary receptor potentials. In contrast to decyl-thio-trifluoro-propanone, (+/-)-linalool and 1-heptanol seem to interfere with later processes of the transduction cascade, possibly the opening of ion channels. (+info)A novel push-pull Diels-Alder diene: reactions of 4-alkoxy- or 4-phenylsulfenyl-5-chalcogene-substituted 1-phenylpenta-2,4-dien-1-one with electron-deficient dienophiles. (6/176)
5-(phenylselenenyl)- and 5-(phenylsulfenyl)-4-ethoxy-1-phenyl-2,4-pentadien-1-ones (2) and (3) underwent [4+2] cycloaddition with N-methyl and N-phenylmaleimides and successive isomerization to give the 7-benzoyl-3a,4,5,7a-tetrahydro-1H-isoindole-1,3(2H)-diones 5, 8 and 9 in good yields. The 4-ethoxy group on the 2,4-pentadien-1-one was found to be effective to facilitate the cycloaddition with dienophiles. We also performed other [4+2] cycloadditions of 2,4-pentadien-1-ones with DMAD or naphthoquinone. (+info)Adaptation in pheromone-sensitive trichoid sensilla of the hawkmoth Manduca sexta. (7/176)
In extracellular tip recordings from long trichoid sensilla of male Manduca sexta moths, we studied dose-response relationships in response to bombykal stimuli of two different durations in the adapted and the non-adapted state. Bombykal-responsive cells could be distinguished from non-bombykal-sensitive cells in each trichoid sensillum because the bombykal-responsive cell always generated the action potentials of larger initial amplitude. The bombykal cell, which was recorded at a defined location within a distal flagellar annulus, can resolve at least four log(10)-units of pheromone concentrations but is apparently unable to encode all stimulus durations tested. Parameters of the amplitude-modulated sensillar potential and the frequency-modulated action potential responses were examined in different states of adaptation. Evidence is presented for the existence of several mechanisms of adaptation, which affect distinct steps of the transduction cascade. After adapting pheromone stimuli, the sensillar potential rises to a lower amplitude and declines faster compared with the non-adapted response. In addition, the frequency of the adapted action potential response is reduced. Only the time of rise of the sensillar potential is differentially affected by adapting pheromone stimuli of different duration. The time of rise does not increase after short, but only after long, adapting stimuli. Both short and long adapting stimuli shift the dose-response curves of the sensillar potential amplitude, as well as the initial slope of its rising phase, to higher stimulus concentrations by approximately one log(10)-unit. The shift in the dose-response curve of the action potential response is larger than for the sensillar potential response, suggesting that an additional adaptation mechanism acts at the level of action potential generation. Furthermore, a faster decline of the sensillar potential after short and long adapting stimuli suggests that the resting potential of the olfactory receptor neuron is stabilized. (+info)Synthesis and characterization of hexadecadienyl compounds with a conjugated diene system, sex pheromone of the persimmon fruit moth and related compounds. (8/176)
Hexadecadien-1-ol and the derivatives (acetate and aldehyde) with a conjugated diene system have recently been identified from a pheromone gland extract of the persimmon fruit moth (Stathmopoda masinissa), a pest insect of persimmon fruits distributed in East Asia. The alcohol and acetate showed their base peaks at m/z 79 in a GC-MS analysis by electron impact ionization, but the aldehyde produced a unique base peak at m/z 84, suggesting a 4,6-diene structure. To confirm this inference, four geometrical isomers of each 4,6-hexadecadienyl compound were synthesized by two different routes in which one of two double bonds was furnished in a highly stereoselective manner. Separation of the two isomers synthesized together by each route was facilely accomplished by preparative HPLC. Their mass spectra coincided well with those of natural components, indicating that they were available for use as authentic standards for determining the configuration of the natural pheromone. Furthermore, other hexadecadienyl compounds, including the conjugated diene system between the 3- and 10-positions, were synthesized to accumulate the spectral data of pheromone candidates. 5,7-Hexadecadienal interestingly showed the base peak at m/z 80; meanwhile, the base peaks of its alcohol and acetate were detected at m/z 79 like the corresponding 4,6-dienes. The base peaks of all 6,8-, 7,9-, and 8,10-dienes universally appeared at m/z 67 like 9,11-, 10,12-, and 13,15-dienes, the spectra of which have already been published. Although 3,5-hexadecadienal was not prepared, base peaks at m/z 67 and 79 were recorded for the alcohol and acetate, respectively. (+info)Cooperative catalysis approach to intramolecular hydroacylation<...
Recent advances in transition metal-catalysed hydroacylation of alkene by Avipsa Ghosh, Kirsten F. Johnson et al.
Hydroacylation of 1-alkene with heteroaromatic aldehyde by Rh(I) and additives<...
Discount China Wholesale Piperine 99%(CAS#94-62-2) 20MG/vial, FREE SHIPPING [PTC-RP0-1561]- US$103.00 - Allcosmeticsource.com
Stereoselective allylboration of imines and indoles under mild conditions. An in situ E/Z isomerization of imines by...
Phthalides by rhodium-catalyzed ketone hydroacylation. - MySci...
Rh-Catalyzed Enantioselective Diboration of Simple Alkenes: Reaction Development and Substrate Scope
The effects of amine and acid catalysts on efficient chelation-assisted hydroacylation of alkene with aliphatic aldehyde -...
ENHANCEMENT OF THE CYTOTOXIC ACTIVITY OF SOME α,β-UNSATURATED KETONES THROUGH AUXILIARY BINDING
2-[(9-Borabicyclo[3.3.1]nonan-9-yl)oxy]ethan-1-amine | C10H20BNO - PubChem
Chapter 10 Conjugation in Alkadienes and Allylic Systems - PDF
Alkadienes, allylic systems, and pigments - The WikiPremed MCAT Course
Mechanism of the C5 stereoinversion reaction in the biosynthesis of carbapenem antibiotics<...
中国科学院上海有机化学研究所机构知识库(SIOC OpenIR): Pd-catalyzed intramolecular aminofluorination of allylic sulfamides
人才库----中国科学院兰州化学物理研究所
Asymmetric α-Photoalkylation of β-Ketocarbonyls by Primary Amine Catalysis: Facile Access to Acyclic All-Carbon Quaternary...
N-Heterocyclic Carbene-Catalyzed Cascade Reaction Involving the Hydroacylation of Unactivated Alkynes
Cascade reaction - Wikipedia
Download A Clinical Application Of Bions Concepts Volume 1 Dreaming Transformation Containment And Change
Vibeke Henriette Lauridsen - Research outputs - Research - Aarhus University
Platinum catalysed 1,4-diboration of α,β-unsaturated ketones<...
Magnus Haugaard Rønne - Publikationer - Forskning - Aarhus Universitet
Highly facile and regio-selective synthesis of pyrazolo[1,5-a]pyrimidines via reactions of 1,2-allenic ketones with...
US6036890A - Diaryl-2H-naphthopyrans - Google Patents
A DFT study of endocyclic allenes: unprecedentedly superbasic hydrocarbons
Stereoselective Synthesis of Monofluoroalkyl α,β-Unsaturated Ketones From Allenyl Carbinol Esters Mediated by Gold and...
Plus it
Stoichiometric and Catalytic Dimerization of Conjugated Dienes with (C|sub|5|/sub|R|sub|5|/sub|)Ru(diene)|sup|+|/sup| -...
E,E)-2,4-Hexadienal
The School-wide PBIS& PSM/RtI Link - ppt download
dienes
Preventing Chronic Cluster Headaches - Cluster Headache Pain Can Be Relieved | HowStuffWorks
Revised ICHD-3 Criteria Identifies Distinct Features of Chronic Cluster Headache - Neurology Advisor
Chronic cluster headache sufferer of 8yrs Esa failed assesment | OUCH(uk) - Cluster Headache Charity
Occipital Nerve Stimulation Produces Lasting Improvements in Refractory Chronic Cluster Headache | Neuro News Now
intractable chronic cluster headache Archives - Reed Migraine Centers
Implantation of a sphenopalatine ganglion stimulation device for chronic cluster headache | NICE
Ir(I)-catalyzed intermolecular regio- and enantioselective hydroamination of alkenes with heteroaromatic amines<...
Percutaneous Bioelectric Current Stimulation for Chronic Cluster Heada | JPR
Palladium-Catalysed Construction of All-Carbon Quaternary Centres with Propargylic Electrophiles:Challenges in the Simultaneous...
Bions, Protocells, Biogenesis, Pleomorphism and Genetics
Ligand-controlled palladium catalysis enables switch between mono- and di-arylation of primary aromatic amines with 2...
Monosubstituted alkene | Article about monosubstituted alkene by The Free Dictionary
Allenes as carbon nucleophiles in palladium-catalyzed reactions : Observation of anti attack of allenes on (pi-allyl)palladium...
Unprecedented Cu-Catalyzed Coupling of Internal 1,3-Diynes with Azides: One-Pot Tandem Cyclizations Involving 1,3-Dipolar...
Connectivity of an effective hypothalamic surgical target for cluster headache. - SCNi
Henley-In-Arden Medical Practice - Library - Health A-Z
Pericyclic Analogies
Interview With Wayne Perry The Sinus Buster ! | Allentrepreneur
PPT - HCS 446 Academic Coach/uophelp PowerPoint Presentation - ID:7237938
Enantioselective synthesis of bioactive molecules via metal-catalysed kinetic resolution of benzylic alcohols and azido...
Ruthenium-Catalyzed Alkene-Alkyne Coupling of Disubstituted Olefins: Application to the Stereoselective Synthesis of...
Difference between revisions of Smolke:Research - OpenWetWare
Progress towards the synthesis of perophoramidine : formation of the contiguous quaternary centres
Hydroamination via organocatalysis « Naturalproductmans Blog
Alkoxycarbonylation of allenes - regioselective switching by ligand « Naturalproductmans Blog
Polynuclear lanthanide-diketonato clusters for the catalytic hydroboration of carboxamides and esters<...
Bronsted Acids and Bases - CHEMISTRY COMMUNITY
Addition Of Halogen To Dienes Assignment Help
TDMS Study 93023-06 Pathology Tables
Enantioselective synthesis of atorvastatin
Professor John Bower - People in the School of Chemistry publications
PROCORE - France/Hong Kong Joint Research Scheme 2008/2009 Supported Applications
CHEMISTRY COMMUNITY - Search
Simmons-Smith reaction
Friedrich, E. C.; Niyati-Shirkhodaee, F. (1991). "Regioselectivity and Solvent Effects in Cyclopropanation of Alkadienes". J. ...
Dicyclopentadiene
"Cyclopentadiene Dimerization Kinetics in the Presence of C5 Alkenes and Alkadienes". Industrial & Engineering Chemistry ...
Pentadiene
doi:10.1021/jp076572o v t e (Alkadienes, All stub articles, Hydrocarbon stubs). ...
Botryococcus braunii
The A race produces alkadienes and alkatrienes (derivatives of fatty acids) wherein n is an odd number 23 through 31. The B ... see vegetable oil refining). Botryococcenes are preferred over alkadienes and alkatrienes for hydrocracking as botryococcenes ... The vast majority of these hydrocarbons are botryocuccus oils: botryococcenes, alkadienes and alkatrienes. Transesterification ...
Ivan Ostromislensky
The book also described 16 original methods of industrial synthesis and polymerization of dialkenes (alkadienes). In 1910s, ...
Cycloalkene
163-193, ISBN 978-0-12-800780-8, retrieved 2022-11-17 "3.4: Alkenes, Cycloalkenes, and Alkadienes". Chemistry LibreTexts. 2014- ...
Isoprene
Alkadienes, Hemiterpenes, IARC Group 2B carcinogens, Monomers, Conjugated dienes). ...
Propadiene
Alkadienes). ...
Butadiene
Alkadienes, Hazardous air pollutants, Monomers, IARC Group 1 carcinogens, U.S. Synthetic Rubber Program, Commodity chemicals, ...
List of MeSH codes (D02)
... alkadienes MeSH D02.455.326.271.665.146.240 - butadienes MeSH D02.455.326.271.665.146.280 - chloroprene MeSH D02.455.326.271. ...
1,2-Butadiene
Alkadienes). ...
Piperylene
Alkadienes, Conjugated dienes, All stub articles, Hydrocarbon stubs). ...
Wood ash
5 alkadienes, 5 alkynes and several alkanes and arenes in proportions. Ethene, acetylene and benzene were a major part at ...
1,5-Hexadiene
Alkadienes, Monomers). ...
Dimethylbutadiene
Alkadienes). ...
1,7-Octadiene
Alkadienes, All stub articles, Organic compound stubs). ...
Simmons-Smith reaction - Wikipedia
Subject: Ampulex compressa and alkanes / Text availability: Citation in PubAg - PubAg Search Results
NIOSHTIC-2 Search Results - Full View
Dryad Data -- The evolution of a complex trait: cuticular hydrocarbons in ants evolve independent from phylogenetic constraints
The introduction history of invasive garden ants in Europe: Integrating genetic, chemical and behavioural approaches | BMC...
Frontiers | Multimodal Signaling in Myrmecophilous Butterflies
C14-Hydrocarbons - Mahendra Gaikwad
Yasushi Nishihara - Research output - Okayama University
Journal name: Arthropod structure & development / Subject: alkanes / Text availability: Citation in PubAg - PubAg Search Results
10.6: Additions to conjugated dienes - Chemistry LibreTexts
English-Armenian Medical - Terms starting with 'L' - MEDINDEX.AM
ESDU: Physical Data, Chemical Engineering
Vatiquinone, バチキノン « New Drug Approvals
ESDU: Physical Data, Chemical Engineering
Buy Solution of task 438 of Chemistry Book Shimanovich 2003 and download
Assessment by GC and GC-MS of volatile hydrocarbons from ... Pages 1-13 - Flip PDF Download | FlipHTML5
2 Single-ion monitoring by GC-MS of Cs alkenes and alkadienes from the burning of biomass (barley straw, methylsilicone column ... Isoprene was found to be more easily lost than 1,3-butadieneamong the alkadienes. Complementary low-volume samples on single- ... Among 21 recorded alkenes and alkadienes, ethene was predominant, and thenext most prominent species were propene and 1,3- ... 0.3Alkadienes 3.8 4.3 2.6 1.6C3 Propadiene 0.6 1.5 0.9 0.1C4 l,3-Butadiene 1.4 1.5 0,37 0.25CS Isoprene 0.75 0.45 0.24 0.08 ...
OPAC
OPAC
Unsaturated hydrocarbons: Definition | Settala Gas
Статьи 2001, Школа, муравьи и компания
Peer review
Publications P.E. de Jongh - Materials Chemistry and Catalysis
Incoming Sudents
DeCS
Squalene | Profiles RNS
Bernstein DI, Munoz FM, Callahan ST, Rupp R, Wootton SH, Edwards KM, Turley CB, Stanberry LR, Patel SM, Mcneal MM, Pichon S, Amegashie C, Bellamy AR. Safety and efficacy of a cytomegalovirus glycoprotein B (gB) vaccine in adolescent girls: A randomized clinical trial. Vaccine. 2016 Jan 12; 34(3):313-9 ...
Alkenes and alkadienes2
- In contrast, the presence or absence of alkenes and alkadienes was highly conserved within the C. levior group. (datadryad.org)
- Among 21 recorded alkenes and alkadienes, ethene was predominant, and thenext most prominent species were propene and 1,3-butadiene. (fliphtml5.com)
Diolefins or alkadienes1
- 438. Which hydrocarbons are called dienes (diolefins or alkadienes)? (plati-1.ru)