Fatigue Syndrome, Chronic: A syndrome characterized by persistent or recurrent fatigue, diffuse musculoskeletal pain, sleep disturbances, and subjective cognitive impairment of 6 months duration or longer. Symptoms are not caused by ongoing exertion; are not relieved by rest; and result in a substantial reduction of previous levels of occupational, educational, social, or personal activities. Minor alterations of immune, neuroendocrine, and autonomic function may be associated with this syndrome. There is also considerable overlap between this condition and FIBROMYALGIA. (From Semin Neurol 1998;18(2):237-42; Ann Intern Med 1994 Dec 15;121(12): 953-9)Pleurodynia, Epidemic: An acute, febrile, infectious disease generally occurring in epidemics. It is usually caused by coxsackieviruses B and sometimes by coxsackieviruses A; echoviruses; or other enteroviruses.Bipolar Disorder: A major affective disorder marked by severe mood swings (manic or major depressive episodes) and a tendency to remission and recurrence.Attention Deficit Disorder with Hyperactivity: A behavior disorder originating in childhood in which the essential features are signs of developmentally inappropriate inattention, impulsivity, and hyperactivity. Although most individuals have symptoms of both inattention and hyperactivity-impulsivity, one or the other pattern may be predominant. The disorder is more frequent in males than females. Onset is in childhood. Symptoms often attenuate during late adolescence although a minority experience the full complement of symptoms into mid-adulthood. (From DSM-V)Amyotrophic Lateral Sclerosis: A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94)Gastroesophageal Reflux: Retrograde flow of gastric juice (GASTRIC ACID) and/or duodenal contents (BILE ACIDS; PANCREATIC JUICE) into the distal ESOPHAGUS, commonly due to incompetence of the LOWER ESOPHAGEAL SPHINCTER.Irritable Bowel Syndrome: A disorder with chronic or recurrent colonic symptoms without a clearcut etiology. This condition is characterized by chronic or recurrent ABDOMINAL PAIN, bloating, MUCUS in FECES, and an erratic disturbance of DEFECATION.Encephalomyelitis: A general term indicating inflammation of the BRAIN and SPINAL CORD, often used to indicate an infectious process, but also applicable to a variety of autoimmune and toxic-metabolic conditions. There is significant overlap regarding the usage of this term and ENCEPHALITIS in the literature.Anxiety Disorders: Persistent and disabling ANXIETY.Depressive Disorder, Major: Marked depression appearing in the involution period and characterized by hallucinations, delusions, paranoia, and agitation.Internet: A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.Developing Countries: Countries in the process of change with economic growth, that is, an increase in production, per capita consumption, and income. The process of economic growth involves better utilization of natural and human resources, which results in a change in the social, political, and economic structures.Software: Sequential operating programs and data which instruct the functioning of a digital computer.Medication Errors: Errors in prescribing, dispensing, or administering medication with the result that the patient fails to receive the correct drug or the indicated proper drug dosage.Waiting Lists: Prospective patient listings for appointments or treatments.Medication Adherence: Voluntary cooperation of the patient in taking drugs or medicine as prescribed. This includes timing, dosage, and frequency.Developed Countries: Countries that have reached a level of economic achievement through an increase of production, per capita income and consumption, and utilization of natural and human resources.User-Computer Interface: The portion of an interactive computer program that issues messages to and receives commands from a user.Algorithms: A procedure consisting of a sequence of algebraic formulas and/or logical steps to calculate or determine a given task.Calcium Oxalate: The calcium salt of oxalic acid, occurring in the urine as crystals and in certain calculi.5-alpha Reductase Inhibitors: Drugs that inhibit 3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE. They are commonly used to reduce the production of DIHYDROTESTOSTERONE.3-Oxo-5-alpha-Steroid 4-Dehydrogenase: An enzyme that catalyzes the reduction of TESTOSTERONE to 5-ALPHA DIHYDROTESTOSTERONE.Testosterone: A potent androgenic steroid and major product secreted by the LEYDIG CELLS of the TESTIS. Its production is stimulated by LUTEINIZING HORMONE from the PITUITARY GLAND. In turn, testosterone exerts feedback control of the pituitary LH and FSH secretion. Depending on the tissues, testosterone can be further converted to DIHYDROTESTOSTERONE or ESTRADIOL.Azasteroids: Steroidal compounds in which one or more carbon atoms in the steroid ring system have been substituted with nitrogen atoms.Finasteride: An orally active 3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE inhibitor. It is used as a surgical alternative for treatment of benign PROSTATIC HYPERPLASIA.Cholestenone 5 alpha-Reductase: An oxidoreductase that catalyzes the conversion of 3-oxo-delta4 steroids into their corresponding 5alpha form. It plays an important role in the conversion of TESTOSTERONE into DIHYDROTESTOSTERONE and PROGESTERONE into DIHYDROPROGESTERONE.Dihydrotestosterone: A potent androgenic metabolite of TESTOSTERONE. It is produced by the action of the enzyme 3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE.Leydig Cells: Steroid-producing cells in the interstitial tissue of the TESTIS. They are under the regulation of PITUITARY HORMONES; LUTEINIZING HORMONE; or interstitial cell-stimulating hormone. TESTOSTERONE is the major androgen (ANDROGENS) produced.Urinary Retention: Inability to empty the URINARY BLADDER with voiding (URINATION).Oxidoreductases Acting on CH-CH Group Donors: A subclass of enzymes which includes all dehydrogenases acting on carbon-carbon bonds. This enzyme group includes all the enzymes that introduce double bonds into substrates by direct dehydrogenation of carbon-carbon single bonds.Pharmaceutical Preparations: Drugs intended for human or veterinary use, presented in their finished dosage form. Included here are materials used in the preparation and/or formulation of the finished dosage form.Acne Keloid: A type of acneiform disorder in which secondary pyogenic infection in and around pilosebaceous structures ends in keloidal scarring. It manifests as persistent folliculitis of the back of the neck associated with occlusion of the follicular orifices. It is most often encountered in black or Asian men.Pierre Robin Syndrome: Congenital malformation characterized by MICROGNATHIA or RETROGNATHIA; GLOSSOPTOSIS and CLEFT PALATE. The mandibular abnormalities often result in difficulties in sucking and swallowing. The syndrome may be isolated or associated with other syndromes (e.g., ANDERSEN SYNDROME; CAMPOMELIC DYSPLASIA). Developmental mis-expression of SOX9 TRANSCRIPTION FACTOR gene on chromosome 17q and its surrounding region is associated with the syndrome.Mouth Rehabilitation: Process of restoring damaged or decayed teeth using various restorative and non-cosmetic materials so that oral health is improved.Chin: The anatomical frontal portion of the mandible, also known as the mentum, that contains the line of fusion of the two separate halves of the mandible (symphysis menti). This line of fusion divides inferiorly to enclose a triangular area called the mental protuberance. On each side, inferior to the second premolar tooth, is the mental foramen for the passage of blood vessels and a nerve.Actinomycetaceae: A family of bacteria including numerous parasitic and pathogenic forms.PhosphoproteinsGram-Positive Cocci: Coccus-shaped bacteria that retain the crystal violet stain when treated by Gram's method.DNA, Ribosomal: DNA sequences encoding RIBOSOMAL RNA and the segments of DNA separating the individual ribosomal RNA genes, referred to as RIBOSOMAL SPACER DNA.Clostridium: A genus of motile or nonmotile gram-positive bacteria of the family Clostridiaceae. Many species have been identified with some being pathogenic. They occur in water, soil, and in the intestinal tract of humans and lower animals.Sigma Factor: A protein which is a subunit of RNA polymerase. It effects initiation of specific RNA chains from DNA.Receptors, sigma: A class of cell surface receptors recognized by its pharmacological profile. Sigma receptors were originally considered to be opioid receptors because they bind certain synthetic opioids. However they also interact with a variety of other psychoactive drugs, and their endogenous ligand is not known (although they can react to certain endogenous steroids). Sigma receptors are found in the immune, endocrine, and nervous systems, and in some peripheral tissues.RNA Polymerase Sigma 54: A DNA-directed RNA polymerase found in BACTERIA. It is a holoenzyme that consists of multiple subunits including sigma factor 54.DNA-Directed RNA Polymerases: Enzymes that catalyze DNA template-directed extension of the 3'-end of an RNA strand one nucleotide at a time. They can initiate a chain de novo. In eukaryotes, three forms of the enzyme have been distinguished on the basis of sensitivity to alpha-amanitin, and the type of RNA synthesized. (From Enzyme Nomenclature, 1992).Gene Expression Regulation, Bacterial: Any of the processes by which cytoplasmic or intercellular factors influence the differential control of gene action in bacteria.Bacterial Proteins: Proteins found in any species of bacterium.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Escherichia coli: A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.Premature Birth: CHILDBIRTH before 37 weeks of PREGNANCY (259 days from the first day of the mother's last menstrual period, or 245 days after FERTILIZATION).Progestins: Compounds that interact with PROGESTERONE RECEPTORS in target tissues to bring about the effects similar to those of PROGESTERONE. Primary actions of progestins, including natural and synthetic steroids, are on the UTERUS and the MAMMARY GLAND in preparation for and in maintenance of PREGNANCY.Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.Meta-Analysis as Topic: A quantitative method of combining the results of independent studies (usually drawn from the published literature) and synthesizing summaries and conclusions which may be used to evaluate therapeutic effectiveness, plan new studies, etc., with application chiefly in the areas of research and medicine.Infant, Newborn: An infant during the first month after birth.Infant, Premature: A human infant born before 37 weeks of GESTATION.Birth Weight: The mass or quantity of heaviness of an individual at BIRTH. It is expressed by units of pounds or kilograms.Obstetric Labor, Premature: Onset of OBSTETRIC LABOR before term (TERM BIRTH) but usually after the FETUS has become viable. In humans, it occurs sometime during the 29th through 38th week of PREGNANCY. TOCOLYSIS inhibits premature labor and can prevent the BIRTH of premature infants (INFANT, PREMATURE).Gestational Age: The age of the conceptus, beginning from the time of FERTILIZATION. In clinical obstetrics, the gestational age is often estimated as the time from the last day of the last MENSTRUATION which is about 2 weeks before OVULATION and fertilization.Progesterone: The major progestational steroid that is secreted primarily by the CORPUS LUTEUM and the PLACENTA. Progesterone acts on the UTERUS, the MAMMARY GLANDS and the BRAIN. It is required in EMBRYO IMPLANTATION; PREGNANCY maintenance, and the development of mammary tissue for MILK production. Progesterone, converted from PREGNENOLONE, also serves as an intermediate in the biosynthesis of GONADAL STEROID HORMONES and adrenal CORTICOSTEROIDS.Algestone Acetophenide: A progesterone that has been used in ESTRUS SYNCHRONIZATION and has been evaluated as an injectable contraceptive in combination with estradiol enanthate. It is also used therapeutically as a topical anti-inflammatory and is applied topically in the treatment of ACNE.Algestone: A synthetic progestational dihydroxy derivative of PROGESTERONE. Its acetonide possesses anti-inflammatory properties.Contraceptive Agents, Female: Chemical substances or agents with contraceptive activity in females. Use for female contraceptive agents in general or for which there is no specific heading.Contraceptives, Oral: Compounds, usually hormonal, taken orally in order to block ovulation and prevent the occurrence of pregnancy. The hormones are generally estrogen or progesterone or both.Contraceptives, Oral, Hormonal: Oral contraceptives which owe their effectiveness to hormonal preparations.Ovulation: The discharge of an OVUM from a rupturing follicle in the OVARY.Contraceptives, Oral, Synthetic: Oral contraceptives which owe their effectiveness to synthetic preparations.Cardiovascular System: The HEART and the BLOOD VESSELS by which BLOOD is pumped and circulated through the body.Contraceptive Agents: Chemical substances that prevent or reduce the probability of CONCEPTION.Endometrium: The mucous membrane lining of the uterine cavity that is hormonally responsive during the MENSTRUAL CYCLE and PREGNANCY. The endometrium undergoes cyclic changes that characterize MENSTRUATION. After successful FERTILIZATION, it serves to sustain the developing embryo.Stem Cells: Relatively undifferentiated cells that retain the ability to divide and proliferate throughout postnatal life to provide progenitor cells that can differentiate into specialized cells.Patents as Topic: Exclusive legal rights or privileges applied to inventions, plants, etc.Game Theory: Theoretical construct used in applied mathematics to analyze certain situations in which there is an interplay between parties that may have similar, opposed, or mixed interests. In a typical game, decision-making "players," who each have their own goals, try to gain advantage over the other parties by anticipating each other's decisions; the game is finally resolved as a consequence of the players' decisions.Games, Experimental: Games designed to provide information on hypotheses, policies, procedures, or strategies.Punishment: The application of an unpleasant stimulus or penalty for the purpose of eliminating or correcting undesirable behavior.Hematopoietic Stem Cells: Progenitor cells from which all blood cells derive.Stem Cell Transplantation: The transfer of STEM CELLS from one individual to another within the same species (TRANSPLANTATION, HOMOLOGOUS) or between species (XENOTRANSPLANTATION), or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). The source and location of the stem cells determines their potency or pluripotency to differentiate into various cell types.Embryonic Stem Cells: Cells derived from the BLASTOCYST INNER CELL MASS which forms before implantation in the uterine wall. They retain the ability to divide, proliferate and provide progenitor cells that can differentiate into specialized cells.Cooperative Behavior: The interaction of two or more persons or organizations directed toward a common goal which is mutually beneficial. An act or instance of working or acting together for a common purpose or benefit, i.e., joint action. (From Random House Dictionary Unabridged, 2d ed)

Accumulation and mobilization of triglycerides and cholesteryl esters in Leydig tumor cells. (1/5)

Incubating MA-10 Leydig tumor cells with sodium oleate led to the accumulation of triglyceride within the cells. Triglycerides were deposited in a time- and dose-dependent fashion. Cellular triglyceride promoted storage of cholesteryl ester. As much cholesteryl ester was stored in oleate-treated cells as in cells treated with saturating concentrations of low density lipoprotein. Addition of both oleate and low density lipoprotein resulted in additive accumulation of cholesteryl esters. Cholesteryl esters in cells loaded with triglyceride by oleate treatment were mobilized in response to dibutyryl-cAMP to an extent similar to that in cells containing low triglyceride concentrations. Dibutyryl-cAMP stimulated cholesteryl ester mobilization under all conditions, and stimulated triglyceride mobilization when adequate fatty acid acceptors were available. The results indicate that while triglyceride accumulation in MA-10 cells promoted cholesteryl ester deposition, it did not impair cAMP-dependent cholesteryl ester hydrolysis or steroid hormone production.  (+info)

Failure of two progesterone antagonists, mifepristone and onapristone, to affect luteal activity in lactating rats. (2/5)

The progesterone antagonists, mifepristone (RU-38,486) and onapristone (ZK-98,299), given as 2 mg daily, did not markedly affect lactation in rats. Both litter growth and time spent by 10-pup litters attached to their mothers were similar in antagonist-treated mothers and in solvent-treated controls. The progesterone antagonists did not affect the steroid content in corpora lutea remaining from the preceding pregnancy. Corpora lutea formed after post-partum ovulation also showed nearly normal function throughout the first 17 days of lactation. It is concluded that progesterone itself plays no role in the initiation or maintenance of luteal function when prolactin secretion is governed through an action independent of the ovaries, as through suckling. Antagonist-treated rats ovulated around Day 13 of lactation despite suckling. This ovulation was not associated with a decrease of progesterone production by the corpora lutea formed after post-partum ovulation. Apparently, elimination of progesterone action may protect corpora lutea from luteolysis. The latter finding indicates a possible role of progesterone in luteolysis and deserves further analysis.  (+info)

Role of actin in the responses of adrenal cells to ACTH and cyclic AMP: inhibition by DNase I. (3/5)

Erythrocyte ghosts were loaded with pancreatic DNase I and fused with Y-1 adrenal tumor cells to test the possibility that this enzyme might inhibit the steroidogenic responses of the cells to ACTH and cyclic AMP. Fusion of erythrocyte ghosts loaded with DNase I, but not those containing albumin, ovalbumin, boiled DNase I, or DNase I with excess G-actin, inhibited the increase in production of 20 alpha-dihydroprogesterone produced by ACTH and dibutyryl cyclic AMP; inhibition was concentration-dependent with 50% inhibition by 3 X 10(7) molecules of DNase I per cell. It was found that inhibition by DNase I was exerted at the step in the steroidogenic pathway at which cholesterol is transported to mitochondria where steroidogenesis begins. This was shown by measuring transport of cholesterol into the inner mitochondrial membrane, by measuring the production of pregnenolone by isolated mitochondria and by demonstrating that DNase I was without effect on the conversion of pregnenolone to 20 alpha-dihydroprogesterone (an end-product of steroid synthesis). The actin content of Y-1 cells was measured by two methods based upon inhibition of DNase I and by SDS gels following centrifugation. The cells were found to contain 2-3 X 10(7) molecules of actin per cell of which two-thirds is present as G-actin. Since DNase I is known to bind to G-actin to give a one to one complex, these and other findings suggest that at least some of the G-actin in the cells may be necessary for the steroidogenic responses to ACTH and cyclic AMP.  (+info)

In vivo and in vitro production of progestins by the corpus luteum of pregnancy of the hamster. (4/5)

Synthesis by hamster corpora lutea (CL) in vitro and serum levels of progesterone (P4), 17 alpha-hydroxyprogesterone (17OHP) and 20 alpha-dihydroprogesterone (20DHP) were assessed for different days of pregnancy (Day 1=day of sperm; Day 16=day of delivery). Highest serum levels of the progestins were observed on Day 14 (P4=33 ng/ml; 17OHP=2 ng/ml; 20DHP=3 ng/ml), followed by precipitous declines on Day 16. The highest in vitro levels of luteal P4 and 17OHP were attained on Days 2-6 (production rates of P4=9-30 ng/mg CL/h; 17OHP=0.6-1.5 ng/mg CL/h), and dropped gradually thereafter. In contrast, the production rate of luteal 20DHP was extremely low on Days 2-8 but abruptly increased on Day 10 and was maintained through Day 14 (4-8 ng/mg CL/h). The in vitro production rates of all 3 progestins dropped abruptly on Day 16. Thus, in the pregnant hamster on the day of parturition (Day 16) there was good agreement between in vivo and in vitro levels of the progestins, contrary to the situation in the rat, where on Day 22 the CL in vitro produce large quantities of P4 and 20DHP while the serum levels are very low (Taya and Greenwald, 1981). Addition of 25 ng/ml of ovine LH to the incubation media containing hamster CL increased production rates of P4 (18-55 ng/mg CL/h) and 17OHP (1.5-2.4 ng/mg CL/h) on Days 2, 4 and 14 of pregnancy but the CL were refractory to this dose of LH from Days 6 to 12. The production rate of luteal 20DHP ws never stimulated by the addition of 25 ng LH. These results indicate that P4 is the principal progestin in the pregnant hamster with 17OHP and 20DHP as minor metabolites. The latter 2 progestins have been measured for the first time in the pregnant hamster and the levels are very low in comparison to the pregnant rat.  (+info)

Effects of peripheral-type benzodiazepine receptor antisense knockout on MA-10 Leydig cell proliferation and steroidogenesis. (5/5)

The peripheral-type benzodiazepine receptor (PBR) is not only widely expressed throughout the body, but it is also genetically conserved from bacteria to humans. Many functions have been attributed to it, but its primary role remains a puzzle. In the current study, we stably transfected cultures of MA-10 Leydig cells with either control or 18-kDa PBR antisense knockout plasmids. The antisense knockout vector was driven by the human enkephalin promoter, which contains two cAMP response elements, such that cAMP treatment of transfected cells could superinduce 18-kDa PBR antisense RNA transcription and, hence, down-regulate endogenous 18-kDa PBR mRNA levels. Control and knockout MA-10 cell lines were then compared at the level of receptor binding, thymidine incorporation, and steroid biosynthesis. Eighteen-kilodalton PBR knockout reduced the maximal binding capacity of tritium-labeled PBR ligands, and the affinity of receptors to the ligands remained unaltered. Additionally, 24-h accumulation of progesterone was lower in the knockout cells. Exposure of the two cell types to 8-bromo-cAMP resulted in a robust increase in steroid production. However, a complex pattern of steroid accumulation was observed, in which further progestin metabolism was indicated. The later decline in accumulated progesterone as well as the synthesis of androstenedione were different in the two cell types. At the level of cell proliferation, reduction of 18-kDa PBR mRNA showed no effect. Thus, we conclude that the 18-kDa PBR may have a more important role in steroidogenesis than in proliferation in this Leydig cell line.  (+info)

*Algestone

Closely related analogues of algestone include 16α-hydroxyprogesterone, algestone acetonide, and algestone acetophenide. A. D. ... Algestone (INN), sold under the brand names Alphasone and Alfasone, is a progestin which is used as a hormonal contraceptive. ... Algestone, also known as 16α,17α-dihydroxyprogesterone or as 16α,17α-dihydroxypregn-4-ene-3,20-dione, is a synthetic pregnane ...

*Algestone acetonide

... (developmental code name W-3395), also known as algestone 16α,17α-acetonide or 16α,17α- ... It is the acetonide cyclic ketal of algestone. J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical ...

*Algestone acetophenide

The drug is the ketal formed between algestone and acetophenone. Algestone acetophenide is said to be both more potent and ... Algestone acetophenide (brand names Neolutin, Droxone, Deladroxone, Decadroxone, Dexadroxate, Bovitrol), also known as ... Unlike many other 17α-hydroxyprogesterone derivatives but similarly to hydroxyprogesterone caproate, algestone acetophenide is ...

*List of progestogen esters

Algestone acetonide (dihydroxyprogesterone acetonide; 16α,17α-isopropylidenedioxyprogesterone; W-3395) Algestone acetophenide ( ...

*Acetophenide

It is seen in algestone acetophenide (dihydroxyprogesterone acetophenide) and amcinafide (triamcinolone acetophenide). ...

*Anagestone

Algestone Chlormadinone Cyproterone Delmadinone Hydromadinone Hydroxyprogesterone Medroxyprogesterone Megestrol Melengestrol J ...

*Estradiol enanthate

It is formulated in combination with dihydroxyprogesterone acetophenide (DHPA; algestone acetophenide), a progestin, and is ...

*C24H34O4

The molecular formula C24H34O4 may refer to: Algestone acetonide Bufalin Medroxyprogesterone acetate Testosterone acetate ...

*Gestonorone caproate

Analogues of gestonorone caproate include algestone acetophenide (dihydroxyprogesterone acetophenide), demegestone, ...

*Gestadienol acetate

Analogues of gestadienol acetate include algestone acetophenide (dihydroxyprogesterone acetophenide), demegestone, gestonorone ...

*16α-Hydroxyprogesterone

5α-Dihydroprogesterone 11-Deoxycorticosterone (21-hydroxyprogesterone) 20-Dihydroprogesterone Algestone (16α,17α- ...

*List of drugs: Al

... algestone (INN) alglucerase (INN) alglucosidase alfa (USAN) alibendol (INN) alicaforsen (INN, USAN) aliconazole (INN) ...

*List of estrogen esters

... all in combination with algestone acetophenide) Estradiol undecylate (Delestrec, Depogin, Primogyn Depot, Progynon Depot, ...

*List of progestogens available in the United States

Acetomepregenol Algestone Algestone acetophenide Allylestrenol Chlormadinone acetate Cyproterone acetate Demegestone ...

*Hydroxyprogesterone caproate

Analogues of OHPC include other 17α-hydroxyprogesterone derivatives such as algestone acetophenide (dihydroxyprogesterone ...

*List of corticosteroid cyclic ketals

Algestone acetophenide (dihydroxyprogesterone acetophenide) Amcinafide (triamcinolone acetophenide) Acroleinides (cyclic ketals ...

*Estradiol butyrate benzoate

Under the tentative brand name Unimens, estradiol butyrate benzoate was studied in combination with the progestogen algestone ...

*C21H30O4

The molecular formula C21H30O4 (molar mass: 346.46 g/mol, exact mass: 346.214409) may refer to: Algestone, a pregnane steroid ...

*List of MeSH codes (D04)

... algestone MeSH D04.808.745.745.654.829.025.025 --- algestone acetophenide MeSH D04.808.745.745.654.829.100 --- 20-alpha- ...
Perludil is an injectable contraceptive that is administered intramuscularly once a month. It consists of two main assets: a progestin (acetophenide algestone) and an estrogen (estradiol enanthate).. The main mode of action is in the contraceptive progestogen agent, which produces a anovulatory effect by inhibiting the secretion of pituitary gonadotropins. Estrogen ensures cyclic endometrial development and predictable bleeding patterns are generally similar to those that occur naturally in menstruation.. PRECAUTIONS: Before treatment and every year for this, it is recommended to perform the medical examination of the drug users, including complete gynecological Pap.. Smoking increases the risk of cardiovascular side effects. The total risk increases with patient age, especially after age 35. It is highly recommended that women who start a hormonal contraceptive therapy of any kind to refrain from smoking.. Perlutal ® has a transient inhibitory effect on ovulation, which does not lead to ...
The IP Industry Base is a public available database about the global market of IP practitioners. Currently is provides high-quality profiles of more than 4900 companies, 15620 professionals and 4260 places. The service of the IP Industry Base is dedicated to technology managers, IP professionals and IPR academia. The open data of the IP Industry Base aims to create transparency for the market of IP practitioners.
C. Matthew Peterson, M.D. Progestogens, Progesterone antagonists, progesterone, and androgens: synthesis, classification and uses ...
At the University Hospital Vrije Universiteit the PET ligand PK11195 labeled with carbon-11, (R)-[11C]PK11195, will be used to study microglia activation in-vivo in patients with traumatic brain damage, Alzheimer disease, multiple sclerosis and neuritis optica, disorders with unknown pathophysiology and treatment difficulties.. PK11195 (1-(2-chlorophenyl)-N-methyl-N-1(1-methylpropyl)-3 isoquinolinecarboxamide) is a highly specific ligand for the peripheral benzodiazepine-binding site, which is particularly abundant on cells of the mononuclear macrophage line (Myers et al., 1991). In normal human brain, the peripheral-type benzodiazepine receptor ligand PK11195 exhibits low to minimal binding primarily associated with the choroid plexus, ependymal linings and glial cells. However, following neuronal damage, the cells involved in the ensuing gliosis, microglia, show a marked increase in expression of these sites (Stephenson et al., 1995;Conway et al., 1998).. PK11195 labeled with carbon-11 is a ...

PatientsLikeMe | Algestone-estradiol report for  patients like youPatientsLikeMe | Algestone-estradiol report for patients like you

Find the most comprehensive real-world treatment information on Algestone-estradiol at PatientsLikeMe. 0 patients with ... bipolar I disorder or psoriasis currently take Algestone-estradiol. ... What is Algestone-estradiol?. Category: Prescription Drugs Most popular types: Alphasone Deladroxate Perlutal Perlutan Topasel ... Estradiol and algestone is an combination estrogen and progesterone contraceptive. It is used for the prevention of pregnancy. ...
more infohttps://www.patientslikeme.com/treatments/show/24696-topasel-side-effects-and-efficacy

PatientsLikeMe | Algestone-estradiol report for  patients like youPatientsLikeMe | Algestone-estradiol report for patients like you

Find the most comprehensive real-world treatment information on Algestone-estradiol at PatientsLikeMe. 0 patients with ... bipolar I disorder or psoriasis currently take Algestone-estradiol. ... What is Algestone-estradiol?. Category: Prescription Drugs Most popular types: Alphasone Deladroxate Perlutal Perlutan Topasel ... Estradiol and algestone is an combination estrogen and progesterone contraceptive. It is used for the prevention of pregnancy. ...
more infohttps://www.patientslikeme.com/treatments/show/24693-algestoneestradiol-side-effects-and-efficacy

Algestone - WikipediaAlgestone - Wikipedia

Closely related analogues of algestone include 16α-hydroxyprogesterone, algestone acetonide, and algestone acetophenide. A. D. ... Algestone (INN), sold under the brand names Alphasone and Alfasone, is a progestin which is used as a hormonal contraceptive. ... Algestone, also known as 16α,17α-dihydroxyprogesterone or as 16α,17α-dihydroxypregn-4-ene-3,20-dione, is a synthetic pregnane ...
more infohttps://en.wikipedia.org/wiki/Algestone

Algestone acetonide - WikipediaAlgestone acetonide - Wikipedia

Algestone acetonide (developmental code name W-3395), also known as algestone 16α,17α-acetonide or 16α,17α- ... It is the acetonide cyclic ketal of algestone. J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical ...
more infohttps://en.wikipedia.org/wiki/Algestone_acetonide

Algestone acetophenide CAS: 24356-94-3Algestone acetophenide CAS: 24356-94-3

... cov tshuaj tiv thaiv kab mob hauv cov tshuaj tiv thaiv.Qhov tshuaj yog ketal tsim ntawm algestone thiab acetophenone.Algestone ... algestone acetophenide yog qhia tias tsis muaj cov kev ua glucocorticoid. ... Algestone acetophenide (USAN) (cov npe hu ua Neolutin, Droxone, Deladroxone, Decadroxone, Dexadroxate, Bovitrol), kuj hu ua ... Algestone acetophenide (USAN) (cov npe hu ua Neolutin, Droxone, Deladroxone, Decadroxone, Dexadroxate, Bovitrol), kuj hu ua ...
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Perludil Algestone Estradiol 1 AMP INJECTION 1mgPerludil Algestone Estradiol 1 AMP INJECTION 1mg

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  • Algestone azetofenido hautsa 16alpha, 17alpha-dihydroxyprogesterone acetofhenide da. (aasraw.com)
  • Algestone (INN), sold under the brand names Alphasone and Alfasone, is a progestin which is used as a hormonal contraceptive. (wikipedia.org)
  • AASraw sintetizatzeko eta ekoizteko gaitasuna gramatikotik Algestone azetofenido (DHPA) hautsaren (24356-94-3) ordenagailu masiboan dago, CGMP erregulazioan eta kalitate kontrol sistema kontrolagarrian. (aasraw.com)
  • It consists of two main assets: a progestin (acetophenide algestone) and an estrogen (estradiol enanthate). (4rx.mx)