Alfaxalone Alfadolone Mixture
Pregnanediones
Sheep, Domestic
Ritanserin
Raphe Nuclei
Receptor, Serotonin, 5-HT2C
A serotonin receptor subtype found primarily in the CENTRAL NERVOUS SYSTEM and the CHOROID PLEXUS. This receptor subtype is believed to mediate the anorectic action of SEROTONIN, while selective antagonists of the 5-HT2C receptor appear to induce ANXIETY. Several isoforms of this receptor subtype exist, due to adenine deaminase editing of the receptor mRNA.
Amphetamines
Serotonin Antagonists
Serotonin
A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily in the central nervous system, gastrointestinal tract, and blood platelets. Serotonin mediates several important physiological functions including neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity. Multiple receptor families (RECEPTORS, SEROTONIN) explain the broad physiological actions and distribution of this biochemical mediator.
Ether
Encyclopedias as Topic
Anesthetics
Opium
The air-dried exudate from the unripe seed capsule of the opium poppy, Papaver somniferum, or its variant, P. album. It contains a number of alkaloids, but only a few - MORPHINE; CODEINE; and PAPAVERINE - have clinical significance. Opium has been used as an analgesic, antitussive, antidiarrheal, and antispasmodic.
Chloroform
Aerosol Propellants
Compressed gases or vapors in a container which, upon release of pressure and expansion through a valve, carry another substance from the container. They are used for cosmetics, household cleaners, and so on. Examples are BUTANES; CARBON DIOXIDE; FLUOROCARBONS; NITROGEN; and PROPANE. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Atmospheric Pressure
Inhalant Abuse
Pressure
Anaesthesia for injection of bleeding oesophageal varices. (1/19)
Patients with haemorrhage from oesophageal varices associated with portal hypertension are poor risks for anaesthesia and surgery. One method of controlling such haemorrhage is injection of the oesophageal varices (sclero-therapy) via an oesophagoscope. Careful preoperative preparation and use of the Sengstaken-Blakemore tube in combination with the anaesthetic technique of intermittent Althesin and suxamethonium with artificial ventilation with nitrous oxide and oxygen enables sclerotherapy to be carried out successfully. (+info)Recovery and simulated driving after intravenous anesthesia with thiopental, methohexital, propanidid, or alphadione. (2/19)
Recovery from anesthesia was assessed in a double-bind manner in 40 healthy volunteer students after intravenous anesthesia with thiopental (6.0 mg/kg), methohexital (2.0 mg/kg), propanidid (6.6 mg/kg), or alphadione (Althesin), 85 mul/kg using a driving simulator 2,4, 6, and 8 hours after injection of the drugs. Clinical recovery was faster after propanidid and methohexital than after thiopental or alphadione. Driving performances remained significantly (P less than 0.05) worse than in a control group for 6 hours after thiopental and for 8 hours after methohexital, and reaction times 8 hours after thiopental remained worse than in the control subjects. After alphadione driving skills were impaired at 6 hours only. Propanidid produced no impairment in driving skills at any time during the experiment. It is concluded that after the doses used in this study patients should not drive or operate machinery for at least 2 hours after propanidid and for at least 8 hours after alphadione. After methohexital and thiopental patients should probably not drive for 24 hours because of the severity of the disturbances at 8 hours. (+info)Evidence that central 5-HT2A and 5-HT2B/C receptors regulate 5-HT cell firing in the dorsal raphe nucleus of the anaesthetised rat. (3/19)
1. Systemic administration of phenethylamine-derived, 5-hydroxytryptamine(2) (5-HT(2)) receptor agonists inhibits the firing of midbrain 5-HT neurones, but the 5-HT receptors involved are poorly defined, and the contribution of peripheral mechanisms is uncertain. This study addresses these issues using extracellular recordings of 5-HT neurones in the dorsal raphe nucleus of anaesthetised rats. 2. The 5-HT(2) receptor agonists DOI ((+/-)-2,5-dimethoxy-4-iodoamphetamine hydrochloride) and DOB ((+/-)-2,5-dimethoxy-4-bromoamphetamine hydrobromide), caused a dose-related (10-100 micro g kg(-1) i.v.) inhibition of 5-HT neuronal activity, with the highest dose reducing firing rates by >80%. 3. Pretreatment with the 5-HT(2) receptor antagonist ritanserin (1 mg kg(-1) i.v.) completely blocked the action of DOI. The 5-HT(2A) receptor antagonist MDL 100,907 (0.2 mg kg(-1) i.v.) blocked the action of both DOI and DOB. In comparison, the 5-HT(2B/C) receptor antagonist SB 206553 (0.5 mg kg(-1) i.v.) caused a small, but statistically significant, shift to the right in the dose response to DOI and DOB. 4. Pretreatment with the peripherally acting 5-HT(2) receptor antagonist BW 501C67 (0.1 mg kg(-1) i.v.) had no effect on the DOI-induced inhibition of 5-HT cell firing, but completely blocked the DOI-induced rise in mean arterial blood pressure. 5. These data indicate that the inhibition of 5-HT cell firing induced by systemic administration of DOI and DOB is mediated predominantly by the 5-HT(2A) receptor-subtype, but that 5-HT(2B/C) receptors also play a minor role. Moreover, central and not peripheral mechanisms are involved. Given evidence that 5-HT(2) receptors are not located on 5-HT neurones, postsynaptic 5-HT feedback mechanisms are implicated. (+info)The effect of ketamine and saffan on the beta-endorphin and ACTH response to hemorrhage in the minipig. (4/19)
The endocrine response is an important component of the physiological response to blood loss. There is some variability in reported levels of certain hormones during hemorrhage such as the stress hormone adrenocorticotrophic hormone (ACTH). Therefore, the effect of two anesthetic agents, ketamine and saffan, on ACTH and beta-endorphin levels during hemorrhage was assessed in 12 minipigs. The animals were divided into two groups, group I saffan and group II ketamine (n=6). Pigs were subjected to a continuous fixed volume hemorrhage under one of the above anesthetics while spontaneously breathing. Blood pressure and heart rate responses were recorded together with beta-endorphin and ACTH levels both before and at 10, 20, 30, 40 min after the onset of bleeding. ACTH levels were higher in the ketamine-anesthetized pigs and rose significantly faster with falling blood pressure than ACTH measured in pigs under saffan anesthesia. In contrast, the hemorrhage induced beta-endorphin increase was not significantly different between the two anesthetic groups. These results indicate that choice of anesthetic agent is important when investigating the hormone response to hemorrhage and may account for the variable hormone levels in the published literature to date. (+info)Absence of coronary artery calcification and all-cause mortality. (5/19)
(+info)Anaesthetic suppression of transmitter actions in neocortex. (6/19)
1. The effects of general anaesthetics were investigated on neuronal sensitivities to transmitter substances, which were determined by iontophoretic applications of acetylcholine, glutamate, N-methyl-D-aspartate (NMDA) and gamma-aminobutyrate (GABA) during intracellular recording in in vitro slice preparations of neocortex (guinea-pig). 2. In most of the 65 neurones studied, perfusion of isoflurane (0.5-2.5 minimum alveolar concentration (MAC)) or Althesin (25-200 microM) and, in some cases, halothane (0.5-2 MAC), markedly reduced the depolarizing responses and associated membrane conductance changes evoked by dendritic applications of acetylcholine, glutamate, NMDA and GABA. 3. The order of depression was acetylcholine greater than glutamate or NMDA much greater than GABA. This selectivity could also be assessed from the EC50 for the isoflurane-induced depression of the just-maximal responses to acetylcholine, which was 0.9 MAC compared with an EC50 = 1.9 MAC for the suppression of glutamate responses. The selectivity was less pronounced in the case of the actions of Althesin, where the EC50s were 75 microM for the depression of acetylcholine responses and 90 microM for the depression of glutamate responses. 4. The hyperpolarizing responses observed when GABA was applied near the perikaryon in 7 neurones, were slightly reduced (approximately 15%) in 4, and unchanged in 3 neurones during anaesthetic application. 5. The pronounced depression of the responsiveness to the putative arousal transmitters and an observed blockade of acetylcholine-induced potentiation of glutamate actions suggest that anaesthetics produce unconsciousness, at least in part, by interfering with subsynaptic mechanisms of neocortical activation. (+info)Facilitation of synaptic transmission by general anaesthetics. (7/19)
1. The actions of five structurally different intravenous and inhalation anaesthetics (alphaxalone/alphadolone, halothane, ketamine, methohexitone, and pentobarbitone) have been studied on synaptic transmission through the cuneate nucleus of the dorsal column-lemniscal afferent pathway in the decerebrate cat. 2. Synaptic input and output were estimated from antidromic and orthodromic potentials, which were evoked by either afferent volleys from the periphery or micro-electrode excitation of the presynaptic fibre terminals in the cuneate and recorded at forelimb nerves and the medial lemniscus. 3. Each of the anaesthetic agents potentiated the efficiency of synaptic transmission, as shown by the elevation of input-output curves constructed from the integrals of the potentials evoked by varying intensities of either peripheral or cuneate stimulation. 4. The excitability of the afferent terminals, as measured at the peripheral nerves by the antidromic responses to micro-electrode stimulation, was depressed by the anaesthetics. Post-synaptic excitability, which was assessed from the direct lemniscal response to intra-nuclear stimulation, did not appear to change. 5. Hypotensive states (mean arterial levels less than 60 torr) produced depolarization of presynaptic terminals and depression of synaptic efficiency and transmission; these changes opposed the primary effects of the general anaesthetics. 6. It is concluded that anaesthetics do not depress activity at all synapses of the central nervous system. Their facilitatory action on cuneate transmission is attributed to an enhanced release of excitatory transmitter; the underlying mechanism may be hyperpolarization of the primary afferent terminals, secondary to an increase in K+ conductance. (+info)Effects of saffan on cardiopulmonary function in healthy cats. (8/19)
The effects of saffan on cardiopulmonary function were evaluated in eight healthy adult cats. Measured values were cardiac output by thermodilution, heart rate by electrocardiogram, arterial blood gases, respiratory rate and systolic, diastolic and mean arterial blood pressures by arterial catheterization. Calculated values included cardiac index, stroke volume and systemic vascular resistance. Statistical analysis employed paired t-tests comparing pre saffan anesthetic induction and post saffan anesthetic parameters over a 120 minute time sequence. Thirty min after saffan induction, significant depression in cardiac output was evident while stroke volume was significantly depressed at 45 and 60 min, systolic blood pressure at 15 min and respiratory rate at 5, 10 and 15 min. No significant changes occurred in cardiac index, heart rate, arterial blood gases, diastolic and mean arterial blood pressure or systemic vascular resistance. It was concluded that saffan causes significant depression of cardiopulmonary function in normal adult cats. (+info)
Althesin (Alfadolone Acetate; Alfaxalone) GlaxoSmithKline
Tumour growth after intravenous, intraperitoneal and subcutaneous inje by B Boeryd, P Lundin et al.
Althesin | definition of althesin by Medical dictionary
Effect of body posture on cardiopulmonary function in horses during five hours of constant-dose halothane anesthesia<...
Intravenous anaesthetics - PgAspirant.in
A Multicenter Study Comparing the Clinical Outcomes of the Nuss and Ravitch Procedures for Repair Of Pediatric Pectus...
Tumour-cell invasion and migration: diversity and escape mechanisms
C-O2 Cardiopulmonary Function Clinic
Plasma pharmacokinetics and pharmacodynamics of alfaxalone in neonatal foals after an intravenous bolus of alfaxalone following...
Althesin interaction with human plasma steroid binding globulins | SpringerLink
Hemodynamic Effects Of Alfaxalone Ana Propofol In Pigs
Risperidone inhibits 5-hydroxytryptaminergic neuronal activity in the dorsal raphe nucleus by local release of 5...
A comparison of respiratory function in pigs anaesthetised by propofol or alfaxalone in combination with dexmedetomidine and...
Evidence that central 5-HT2A and 5-HT2B/C receptors regulate 5-HT cell firing in the dorsal raphe nucleus of the anaesthetised...
Molecular pharmacology of altered cardiopulmonary function in inflammation
- the University of Baths research portal
Information-theoretic method for wavelength selection in bioluminescence tomography | (2013) | Basevi | Publications | Spie
Thymic Disorders Program - Massachusetts General Hospital, Boston, MA
Eye position of cats anaesthetised with alfaxalone or propofol | Veterinary Record
AKC Canine Health Foundation
General Anaesthetics Market 2020 Global Industry - Key Players, Size, Trends, Opportunities, Growth-Analysis to 2026 |...
Apgar score of dog puppies deliverd by cesarean section using alfaxalone or propofol for anesthesia induction - Zurich Open...
Federal Register
::
Schedules of Controlled Substances: Placement of Alfaxalone into Schedule IV
Phaxan™: Intravenous Anaesthetic and Sedative - Drawbridge Pharmaceuticals
Market reviews 2019 | Orion
Science Pinpoints Why General Anaesthetics Worsen Pain in Recovery - Redorbit
D-M - Diazepam and Methohexital (drug combination) | AcronymFinder
Methohexital | definition of methohexital by Medical dictionary
Methohexital - Side Effects, Uses, Dosage, Overdose, Pregnancy, Alcohol | RxWiki
About Hysterectomy | Fibroids
List of MeSH codes (D04)
... alfaxalone alfadolone mixture MeSH D04.808.745.558.783 - tetrahydrocortisone MeSH D04.808.745.620 - pregnanetriol MeSH D04.808. ...
Alfaxalone
Alfadolone was not included in the mixture, as its hypnotic effects were quite weak. An aqueous form of Alfaxan was released in ... Most of these efforts were aimed at making alfaxalone more water-soluble. In 1971, a combination of alfaxalone and alfadolone ... Alfaxalone was marketed in 1971 in combination with alfadolone acetate under the brand name Althesin for human use and Saffan ... Alfaxalone is mostly excreted in the urine, though some is excreted in the bile as well. Alfaxalone, also known as 11-oxo-3α,5α ...
List of drugs: Al
... alfadolone (INN) alfaprostol (INN) alfaxalone (INN) Alfenta (Taylor) redirects to alfentanil alfentanil (INN) alferminogene ... mixture of fexofenadine and pseudoephedrine Allegra (Sanofi-Aventis), also known as fexofenadine Aller-Chlor Allercon Tablet ...
Diethyl ether
... mixture, or chloroform and alcohol to make A.C.E. mixture. In the 21st century, ether is rarely used. The use of flammable ... Alfadolone. *Alfaxalone. *3α-Androstanediol. *Androstenol. *Androsterone. *Certain anabolic-androgenic steroids. *Cholesterol ... A mixture of alcohol and ether, one part of diethyl ether and three parts of ethanol, was known as "Spirit of ether", Hoffman's ... For the same reason it is also used as a component of the fuel mixture for carbureted compression ignition model engines. In ...
1,1,1,2-Tetrafluoroethane
Mixtures with air of the gas 1,1,1,2-tetrafluoroethane are not flammable at atmospheric pressure and temperatures up to 100 °C ... Alfadolone. *Alfaxalone. *3α-Androstanediol. *Androstenol. *Androsterone. *Certain anabolic-androgenic steroids. *Cholesterol ... 212 °F). However, mixtures with high concentrations of air at elevated pressure and/or temperature can be ignited.[23] Contact ... and a methodology for the separation of ternary mixtures". Green Chemistry. 7 (4): 210. doi:10.1039/B412697A.. ...
Sodium thiopental
Alfadolone. *Alfaxalone. *3α-Androstanediol. *Androstenol. *Androsterone. *Certain anabolic-androgenic steroids. *Cholesterol ... Racemic mixture. SMILES. * [Na+].O=C1NC(=S)/N=C(/[O-])C1(C(C)CCC)CC ...
General anaesthetic
An anaesthesia machine allows composing a mixture of oxygen, anaesthetics and ambient air, delivering it to the patient and ...
Methohexital
Alfadolone. *Alfaxalone. *3α-Androstanediol. *Androstenol. *Androsterone. *Certain anabolic-androgenic steroids. *Cholesterol ... ACE mixture. *Helsinki Declaration for Patient Safety in Anaesthesiology. *History of general anesthesia ...
Propofol
... and vecuronium mixtures designed for potential use in anesthesia and patient transport". Journal of Clinical Anesthesia. 8 (4 ... Alfadolone. *Alfaxalone. *3α-Androstanediol. *Androstenol. *Androsterone. *Certain anabolic-androgenic steroids. *Cholesterol ... this formulation was withdrawn from the market and subsequently reformulated as an emulsion of a soya oil/propofol mixture in ... increased in August 2009 due to the Los Angeles County coroner's conclusion that music icon Michael Jackson died from a mixture ...
Stiripentol
It is chiral and is marketed as an equimolar racemic mixture. The R enantiomer appears to be around 2.5 times more active than ... Alfadolone. *Alfaxalone. *3α-Androstanediol. *Androstenol. *Androsterone. *Certain anabolic-androgenic steroids. *Cholesterol ...
Isopropyl alcohol
Water-isopropyl alcohol mixtures have depressed melting points.[9] It has a slightly bitter taste, and is not safe to drink.[9] ... Alfadolone. *Alfaxalone. *3α-Androstanediol. *Androstenol. *Androsterone. *Certain anabolic-androgenic steroids. *Cholesterol ... Crude acetone is hydrogenated in the liquid phase over Raney nickel or a mixture of copper and chromium oxide to give isopropyl ... Indirect hydration reacts propene with sulfuric acid to form a mixture of sulfate esters. This process can use low-quality ...
Amyl alcohol
An amyl alcohol is any of 8 alcohols with the formula C5H12O.[1] A mixture of amyl alcohols (also called amyl alcohol) can be ... Alfadolone. *Alfaxalone. *3α-Androstanediol. *Androstenol. *Androsterone. *Certain anabolic-androgenic steroids. *Cholesterol ... using the reduction of a mixture of trimethyl acetic acid and trimethylacetyl chloride with sodium amalgam. It is a solid that ...
اتیلن - ویکیپدیا، دانشنامهٔ آزاد
Ethylene is separated from the resulting mixture by repeated compression and distillation.[13] In Europe and Asia, ethylene is ... Alfadolone. *Alfaxalone. *3α-Androstanediol. *Androstenol. *Androsterone. *Certain anabolic-androgenic steroids. *Cholesterol ...
Paraldehyde
It may be mixed 1 part paraldehyde with 9 parts saline or, alternatively, with an equal mixture of peanut or olive oil. ... Alfadolone. *Alfaxalone. *3α-Androstanediol. *Androstenol. *Androsterone. *Certain anabolic-androgenic steroids. *Cholesterol ... Wankhede, N N; Wankhede, D S; Lande, M K; Arbad, B R (March 2006). "Densities and ultrasonic velocities of bina ry mixtures of ...
alpha-Pinene
The racemic mixture is present in some oils such as eucalyptus oil and orange peel oil. ... Alfadolone. *Alfaxalone. *3α-Androstanediol. *Androstenol. *Androsterone. *Certain anabolic-androgenic steroids. *Cholesterol ...
Androstanolone
... testosterone ester mixtures (Deposterona, Omnadren, Sustanon, Testoviron Depot)) ... Alfadolone. *Alfaxalone. *3α-Androstanediol. *Androstenol. *Androsterone. *Certain anabolic-androgenic steroids. *Cholesterol ...
Alfaxalone - Wikipedia
Alfadolone was not included in the mixture, as its hypnotic effects were quite weak. An aqueous form of Alfaxan was released in ... Most of these efforts were aimed at making alfaxalone more water-soluble. In 1971, a combination of alfaxalone and alfadolone ... Alfaxalone was marketed in 1971 in combination with alfadolone acetate under the brand name Althesin for human use and Saffan ... Alfaxalone is mostly excreted in the urine, though some is excreted in the bile as well. Alfaxalone, also known as 11-oxo-3α,5α ...
Alfaxalone - Wikipedia
Alfadolone was not included in the mixture, as its hypnotic effects were quite weak.[25] An aqueous form of Alfaxan was ... "Alfaxalone". Drugs.com.. *^ a b c d e f Rezende, Marlis (June 2015). "Reintroduced Anesthetic Alfaxalone" (PDF). Clinicians ... Alfaxalone was marketed in 1971 in combination with alfadolone acetate under the brand name Althesin for human use and Saffan ... In 1971, a combination of alfaxalone and alfadolone acetate was released as the anesthetics Althesin (for human use) and Saffan ...
JCI -
The 2018 Lasker~DeBakey Clinical Medical Research Award recognizes John Baird Glen for the discovery of propofol
... including the steroid mixture of alfaxalone and alfadolone and the sedatives xylazine and droperidol. Eventually, Glen changed ... alfadolone, and other agents. They subsequently spent 2 years searching for an alternative surfactant formulation suitable for ... a series of experiments implicating Cremophor EL as responsible for the anaphylactoid reactions associated with alfaxalone, ...
List of MeSH codes (D04) - Wikipedia
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DeCS - Deleted terms
Comparison of the cerebral function monitor and plasma concentrations of thiopentone and alphaxalone during total i.v....
Search | Global Index Medicus
Alfaxalone Alfadolone Mixture , Apnea , Blood Pressure , Classification , Extremities , Heart Rate , Humans , Injections, ... Animals, Laboratory , Alfaxalone Alfadolone Mixture/administration & dosage , Immunoglobulin E , Histamine , Anesthesia/methods ... Child , Adolescent , Adult , Middle Aged , Humans , Male , Female , Alfaxalone Alfadolone Mixture , Intubation, Intratracheal ... Humans , Male , Female , Alfaxalone Alfadolone Mixture , Drug Hypersensitivity , Bronchial Spasm , Clinical Trials as Topic ...
Search | Global Index Medicus
Alfadolone Acetate
... alphadolone acetate,GR-2/1574,Mixture with alfaxalone,Alfadolone Acetate, Mixture with alfaxalone ... Alfadolone Acetate,(3alpha,5alpha)-21-(Acetyloxy)-3-hydroxypregnane-11,20-dione,3alpha,21-dihydroxy-5alpha-pregnane-11,20-dione ... Therap-Cat: Combination with alfaxalone as anesthetic (intravenous).. Therap-Cat-Vet: Combination with alfaxalone as anesthetic ...
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5-alpha-Dihydroprogesterone | Profiles RNS
MH DELETED MN ADDED MN
Evidence that central 5-HT2A and 5-HT2B/C receptors regulate 5-HT cell firing in the dorsal raphe nucleus of the anaesthetised...
Anesthesia, Intravenous | The Chopra Library
Quantification of collagen and proteoglycan deposition in a murine model of airway remodelling | Respiratory Research | Full...
9 mg alfaxalone and 3 mg alfadolone acetate/ml, Schering-Plough Animal Health, Welwyn Garden City, U.K.). An intra-venous ... PBS at a pressure of 25 cm of this mixture. Due to the increased viscosity of this mixture, compared with paraformaldehyde, a ... Insufflation of the bronchial tree was performed using tracheal instillation of a 1 : 3 mixture of OCT embedding matrix (Cell ...
Application # 2005/0002865. Diagnostic/therapeutic agents - Patents.com
... alfadolone, alfaprostol, alfaxalone, alfentanil, alfuzosin, algestone acetonide, algestone acetophenide, alibendol, aliconazole ... mixtures of any of the foregoing and mixtures with other lipids such as cholesterol. The use of phospholipids predominantly (e. ... The mixture was sonicated for 30 s and analysed by MALDI-MS (ACH-matrix), giving a M+H peak at 1300, expected at 1294-and a M+ ... The mixture was sonicated for 30 s and analysed by MALDI-MS, giving a M+H peak at 668 corresponding to structure from a). [0425 ...
Diethyl ether - Wikipedia
... mixture, or chloroform and alcohol to make A.C.E. mixture. In the 21st century, ether is rarely used. The use of flammable ... Alfadolone. *Alfaxalone. *3α-Androstanediol. *Androstenol. *Androsterone. *Certain anabolic-androgenic steroids. *Cholesterol ... A mixture of alcohol and ether, one part of diethyl ether and three parts of ethanol, was known as "Spirit of ether", Hoffmans ... For the same reason it is also used as a component of the fuel mixture for carbureted compression ignition model engines. In ...
1,1,1,2-Tetrafluoroethane - Wikipedia
Mixtures with air of the gas 1,1,1,2-tetrafluoroethane are not flammable at atmospheric pressure and temperatures up to 100 °C ... Alfadolone. *Alfaxalone. *3α-Androstanediol. *Androstenol. *Androsterone. *Certain anabolic-androgenic steroids. *Cholesterol ... 212 °F). However, mixtures with high concentrations of air at elevated pressure and/or temperature can be ignited.[23] Contact ... and a methodology for the separation of ternary mixtures". Green Chemistry. 7 (4): 210. doi:10.1039/B412697A.. ...
Anesthesia6
- Alfaxalone, also known as alphaxalone or alphaxolone and sold under the brand name Alfaxan, is a neuroactive steroid and general anesthetic which is used currently in veterinary practice as an induction agent for anesthesia and as an injectable anesthetic. (wikipedia.org)
- As an induction agent, alfaxalone causes the animal to relax enough to be intubated, which then allows the administration of inhalational anesthesia. (wikipedia.org)
- Once the administration of alfaxalone stops, the animal quickly recovers from anesthesia. (wikipedia.org)
- Alfaxalone should be administered slowly over a period of at least 60 seconds or until anesthesia is induced, as quick administration increases the risk of apnea. (wikipedia.org)
- For this reason, it is recommended that animals recovering from anesthesia by alfaxalone stay in a quiet, dark area. (wikipedia.org)
- Glen became particularly interested in investigating several newly developed anesthesia agents, including the steroid mixture of alfaxalone and alfadolone and the sedatives xylazine and droperidol. (jci.org)
Metabolism1
- The quick metabolism and elimination of alfaxalone from the body decreases the chance of overdose. (wikipedia.org)
Anesthetic4
- Alfaxalone is used as an induction agent, an injectable anesthetic, and a sedative in animals. (wikipedia.org)
- Despite its use as an anesthetic, alfaxalone itself has no analgesic properties. (wikipedia.org)
- Alfaxalone has been noted to be a good anesthetic agent for dogs with ventricular arrhythmias and for sighthounds. (wikipedia.org)
- Combination with alfaxalone as anesthetic (intravenous). (druglead.com)
Animals1
- When no premedications are used, alfaxalone causes animals (especially cats) to be agitated when recovering. (wikipedia.org)
Agent1
- Premedication (administering sedative drugs prior to induction) increases the potency of alfaxalone as an induction agent. (wikipedia.org)
Volume2
- Alfaxalone can be used as a sedative when given intramuscularly (IM), though this requires a larger volume (and not all countries allow alfaxalone to be administered IM). (wikipedia.org)
- The most common side effect is respiratory depression: in addition to apnea, the most prevalent, alfaxalone can also decrease the respiratory rate, minute volume, and oxygen saturation in the blood. (wikipedia.org)
Requires1
- Getting a good yield of ether requires that ether be distilled out of the reaction mixture before it reverts to ethanol, taking advantage of Le Chatelier's principle . (wikipedia.org)
Common1
- Two methods are practiced industrially, hydroformylation is more common and generates a mixture of isobutyraldehydes , which are hydrogenated to the alcohols and then separated. (worldheritage.org)