Alfaxalone Alfadolone Mixture
Pregnanediones
Anaesthesia for injection of bleeding oesophageal varices. (1/19)
Patients with haemorrhage from oesophageal varices associated with portal hypertension are poor risks for anaesthesia and surgery. One method of controlling such haemorrhage is injection of the oesophageal varices (sclero-therapy) via an oesophagoscope. Careful preoperative preparation and use of the Sengstaken-Blakemore tube in combination with the anaesthetic technique of intermittent Althesin and suxamethonium with artificial ventilation with nitrous oxide and oxygen enables sclerotherapy to be carried out successfully. (+info)Recovery and simulated driving after intravenous anesthesia with thiopental, methohexital, propanidid, or alphadione. (2/19)
Recovery from anesthesia was assessed in a double-bind manner in 40 healthy volunteer students after intravenous anesthesia with thiopental (6.0 mg/kg), methohexital (2.0 mg/kg), propanidid (6.6 mg/kg), or alphadione (Althesin), 85 mul/kg using a driving simulator 2,4, 6, and 8 hours after injection of the drugs. Clinical recovery was faster after propanidid and methohexital than after thiopental or alphadione. Driving performances remained significantly (P less than 0.05) worse than in a control group for 6 hours after thiopental and for 8 hours after methohexital, and reaction times 8 hours after thiopental remained worse than in the control subjects. After alphadione driving skills were impaired at 6 hours only. Propanidid produced no impairment in driving skills at any time during the experiment. It is concluded that after the doses used in this study patients should not drive or operate machinery for at least 2 hours after propanidid and for at least 8 hours after alphadione. After methohexital and thiopental patients should probably not drive for 24 hours because of the severity of the disturbances at 8 hours. (+info)Evidence that central 5-HT2A and 5-HT2B/C receptors regulate 5-HT cell firing in the dorsal raphe nucleus of the anaesthetised rat. (3/19)
1. Systemic administration of phenethylamine-derived, 5-hydroxytryptamine(2) (5-HT(2)) receptor agonists inhibits the firing of midbrain 5-HT neurones, but the 5-HT receptors involved are poorly defined, and the contribution of peripheral mechanisms is uncertain. This study addresses these issues using extracellular recordings of 5-HT neurones in the dorsal raphe nucleus of anaesthetised rats. 2. The 5-HT(2) receptor agonists DOI ((+/-)-2,5-dimethoxy-4-iodoamphetamine hydrochloride) and DOB ((+/-)-2,5-dimethoxy-4-bromoamphetamine hydrobromide), caused a dose-related (10-100 micro g kg(-1) i.v.) inhibition of 5-HT neuronal activity, with the highest dose reducing firing rates by >80%. 3. Pretreatment with the 5-HT(2) receptor antagonist ritanserin (1 mg kg(-1) i.v.) completely blocked the action of DOI. The 5-HT(2A) receptor antagonist MDL 100,907 (0.2 mg kg(-1) i.v.) blocked the action of both DOI and DOB. In comparison, the 5-HT(2B/C) receptor antagonist SB 206553 (0.5 mg kg(-1) i.v.) caused a small, but statistically significant, shift to the right in the dose response to DOI and DOB. 4. Pretreatment with the peripherally acting 5-HT(2) receptor antagonist BW 501C67 (0.1 mg kg(-1) i.v.) had no effect on the DOI-induced inhibition of 5-HT cell firing, but completely blocked the DOI-induced rise in mean arterial blood pressure. 5. These data indicate that the inhibition of 5-HT cell firing induced by systemic administration of DOI and DOB is mediated predominantly by the 5-HT(2A) receptor-subtype, but that 5-HT(2B/C) receptors also play a minor role. Moreover, central and not peripheral mechanisms are involved. Given evidence that 5-HT(2) receptors are not located on 5-HT neurones, postsynaptic 5-HT feedback mechanisms are implicated. (+info)The effect of ketamine and saffan on the beta-endorphin and ACTH response to hemorrhage in the minipig. (4/19)
The endocrine response is an important component of the physiological response to blood loss. There is some variability in reported levels of certain hormones during hemorrhage such as the stress hormone adrenocorticotrophic hormone (ACTH). Therefore, the effect of two anesthetic agents, ketamine and saffan, on ACTH and beta-endorphin levels during hemorrhage was assessed in 12 minipigs. The animals were divided into two groups, group I saffan and group II ketamine (n=6). Pigs were subjected to a continuous fixed volume hemorrhage under one of the above anesthetics while spontaneously breathing. Blood pressure and heart rate responses were recorded together with beta-endorphin and ACTH levels both before and at 10, 20, 30, 40 min after the onset of bleeding. ACTH levels were higher in the ketamine-anesthetized pigs and rose significantly faster with falling blood pressure than ACTH measured in pigs under saffan anesthesia. In contrast, the hemorrhage induced beta-endorphin increase was not significantly different between the two anesthetic groups. These results indicate that choice of anesthetic agent is important when investigating the hormone response to hemorrhage and may account for the variable hormone levels in the published literature to date. (+info)Absence of coronary artery calcification and all-cause mortality. (5/19)
(+info)Anaesthetic suppression of transmitter actions in neocortex. (6/19)
1. The effects of general anaesthetics were investigated on neuronal sensitivities to transmitter substances, which were determined by iontophoretic applications of acetylcholine, glutamate, N-methyl-D-aspartate (NMDA) and gamma-aminobutyrate (GABA) during intracellular recording in in vitro slice preparations of neocortex (guinea-pig). 2. In most of the 65 neurones studied, perfusion of isoflurane (0.5-2.5 minimum alveolar concentration (MAC)) or Althesin (25-200 microM) and, in some cases, halothane (0.5-2 MAC), markedly reduced the depolarizing responses and associated membrane conductance changes evoked by dendritic applications of acetylcholine, glutamate, NMDA and GABA. 3. The order of depression was acetylcholine greater than glutamate or NMDA much greater than GABA. This selectivity could also be assessed from the EC50 for the isoflurane-induced depression of the just-maximal responses to acetylcholine, which was 0.9 MAC compared with an EC50 = 1.9 MAC for the suppression of glutamate responses. The selectivity was less pronounced in the case of the actions of Althesin, where the EC50s were 75 microM for the depression of acetylcholine responses and 90 microM for the depression of glutamate responses. 4. The hyperpolarizing responses observed when GABA was applied near the perikaryon in 7 neurones, were slightly reduced (approximately 15%) in 4, and unchanged in 3 neurones during anaesthetic application. 5. The pronounced depression of the responsiveness to the putative arousal transmitters and an observed blockade of acetylcholine-induced potentiation of glutamate actions suggest that anaesthetics produce unconsciousness, at least in part, by interfering with subsynaptic mechanisms of neocortical activation. (+info)Facilitation of synaptic transmission by general anaesthetics. (7/19)
1. The actions of five structurally different intravenous and inhalation anaesthetics (alphaxalone/alphadolone, halothane, ketamine, methohexitone, and pentobarbitone) have been studied on synaptic transmission through the cuneate nucleus of the dorsal column-lemniscal afferent pathway in the decerebrate cat. 2. Synaptic input and output were estimated from antidromic and orthodromic potentials, which were evoked by either afferent volleys from the periphery or micro-electrode excitation of the presynaptic fibre terminals in the cuneate and recorded at forelimb nerves and the medial lemniscus. 3. Each of the anaesthetic agents potentiated the efficiency of synaptic transmission, as shown by the elevation of input-output curves constructed from the integrals of the potentials evoked by varying intensities of either peripheral or cuneate stimulation. 4. The excitability of the afferent terminals, as measured at the peripheral nerves by the antidromic responses to micro-electrode stimulation, was depressed by the anaesthetics. Post-synaptic excitability, which was assessed from the direct lemniscal response to intra-nuclear stimulation, did not appear to change. 5. Hypotensive states (mean arterial levels less than 60 torr) produced depolarization of presynaptic terminals and depression of synaptic efficiency and transmission; these changes opposed the primary effects of the general anaesthetics. 6. It is concluded that anaesthetics do not depress activity at all synapses of the central nervous system. Their facilitatory action on cuneate transmission is attributed to an enhanced release of excitatory transmitter; the underlying mechanism may be hyperpolarization of the primary afferent terminals, secondary to an increase in K+ conductance. (+info)Effects of saffan on cardiopulmonary function in healthy cats. (8/19)
The effects of saffan on cardiopulmonary function were evaluated in eight healthy adult cats. Measured values were cardiac output by thermodilution, heart rate by electrocardiogram, arterial blood gases, respiratory rate and systolic, diastolic and mean arterial blood pressures by arterial catheterization. Calculated values included cardiac index, stroke volume and systemic vascular resistance. Statistical analysis employed paired t-tests comparing pre saffan anesthetic induction and post saffan anesthetic parameters over a 120 minute time sequence. Thirty min after saffan induction, significant depression in cardiac output was evident while stroke volume was significantly depressed at 45 and 60 min, systolic blood pressure at 15 min and respiratory rate at 5, 10 and 15 min. No significant changes occurred in cardiac index, heart rate, arterial blood gases, diastolic and mean arterial blood pressure or systemic vascular resistance. It was concluded that saffan causes significant depression of cardiopulmonary function in normal adult cats. (+info)
Althesin (Alfadolone Acetate; Alfaxalone) GlaxoSmithKline
Tumour growth after intravenous, intraperitoneal and subcutaneous inje by B Boeryd, P Lundin et al.
Althesin | definition of althesin by Medical dictionary
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Risperidone inhibits 5-hydroxytryptaminergic neuronal activity in the dorsal raphe nucleus by local release of 5...
A comparison of respiratory function in pigs anaesthetised by propofol or alfaxalone in combination with dexmedetomidine and...
Evidence that central 5-HT2A and 5-HT2B/C receptors regulate 5-HT cell firing in the dorsal raphe nucleus of the anaesthetised...
Molecular pharmacology of altered cardiopulmonary function in inflammation - the University of Baths research portal
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Federal Register
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Schedules of Controlled Substances: Placement of Alfaxalone into Schedule IV
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D-M - Diazepam and Methohexital (drug combination) | AcronymFinder
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Alfaxalone
Alfadolone was not included in the mixture, as its hypnotic effects were quite weak. An aqueous form of Alfaxan was released in ... Most of these efforts were aimed at making alfaxalone more water-soluble. In 1971, a combination of alfaxalone and alfadolone ... Alfaxalone was marketed in 1971 in combination with alfadolone acetate under the brand name Althesin for human use and Saffan ... Alfaxalone is mostly excreted in the urine, though some is excreted in the bile as well. Alfaxalone, also known as 11-oxo-3α,5α ...
List of MeSH codes (D04)
... alfaxalone alfadolone mixture MeSH D04.808.745.558.783 - tetrahydrocortisone MeSH D04.808.745.620 - pregnanetriol MeSH D04.808. ...
List of drugs: Al
... alfadolone (INN) alfaprostol (INN) alfaxalone (INN) Alfenta (Taylor) redirects to alfentanil alfentanil (INN) alferminogene ... mixture of fexofenadine and pseudoephedrine Allegra (Sanofi-Aventis), also known as fexofenadine Aller-Chlor Allercon Tablet ...
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Alfaxalone Alfadolone Mixture - Preferred Concept UI. M0362311. Scope note. A 3:1 mixture of alfaxalone with alfadolone acetate ... Mélange alfaxalone alfadolone Entry term(s):. Alfadolone Mixture, Alfaxalone. Alfatesine. Alfathesin. Alphadione. Alphathesin. ... A 3:1 mixture of alfaxalone with alfadolone acetate that previously had been used as a general anesthetic. It is no longer ... Alfaxalone Alfadolone Mixture Entry term(s). Alfadolone Mixture, Alfaxalone Alfathesin - Narrower Concept UI. M0351497. ...
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MeSH Browser
Alfaxalone Alfadolone Mixture Preferred Concept UI. M0362311. Registry Number. 8067-82-1. Scope Note. A 3:1 mixture of ... Alfaxalone Alfadolone Mixture Preferred Term Term UI T414229. Date05/15/2000. LexicalTag NON. ThesaurusID NLM (2001). ... A 3:1 mixture of alfaxalone with alfadolone acetate that previously had been used as a general anesthetic. It is no longer ... Alfaxalone Alfadolone Mixture. Tree Number(s). D04.210.500.745.558.050. Unique ID. D000530. RDF Unique Identifier. http://id. ...
DeCS - Deleted terms
MeSH Browser
Alfaxalone Alfadolone Mixture Preferred Concept UI. M0362311. Registry Number. 8067-82-1. Scope Note. A 3:1 mixture of ... Alfaxalone Alfadolone Mixture Preferred Term Term UI T414229. Date05/15/2000. LexicalTag NON. ThesaurusID NLM (2001). ... A 3:1 mixture of alfaxalone with alfadolone acetate that previously had been used as a general anesthetic. It is no longer ... Alfaxalone Alfadolone Mixture. Tree Number(s). D04.210.500.745.558.050. Unique ID. D000530. RDF Unique Identifier. http://id. ...
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DeCS 2017 - December 21, 2017 version
TERM
Alfaxalone Alfadolone Mixture Alfentanil Algal Proteins Algeria Algestone Algestone Acetophenide Alginates Algorithms TERM ... Complex Mixtures Complex Regional Pain Syndromes Compliance Complicity Compomers Composite Lymphoma Composite Resins Composite ... Ampholyte Mixtures Amphotericin B Ampicillin Ampicillin Resistance Amplified Fragment Length Polymorphism Analysis Amplifiers, ...
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... orbignyi borborygmi borborygmus Bordeaux bordeaux mixture Bordeaux mixture border border cell border cells border disease ... alexithymic alexithymics alexomycin Aleyrodidae AlF ALF alfa alfa-2b AlFABdCTP alfacalcidol alfacon-1 alfacron alfadolone ... alfalfa weevil alfalfa weevils alfamovirus Alfamovirus alfamoviruses alfaprostol alfare alfas alfatesine alfathesin alfaxalone ... acid analyzer aminoacid analyzer amino acid analyzers aminoacid analyzers aminoacidemia amino acid mixture amino acid mixtures ...
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... orbignyi borborygmi borborygmus Bordeaux bordeaux mixture Bordeaux mixture border border cell border cells border disease ... alexithymic alexithymics alexomycin Aleyrodidae AlF ALF alfa alfa-2b AlFABdCTP alfacalcidol alfacon-1 alfacron alfadolone ... alfalfa weevil alfalfa weevils alfamovirus Alfamovirus alfamoviruses alfaprostol alfare alfas alfatesine alfathesin alfaxalone ... acid analyzer aminoacid analyzer amino acid analyzers aminoacid analyzers aminoacidemia amino acid mixture amino acid mixtures ...