Rare leukoencephalopathy with infantile-onset accumulation of Rosenthal fibers in the subpial, periventricular, and subependymal zones of the brain. Rosenthal fibers are GLIAL FIBRILLARY ACIDIC PROTEIN aggregates found in ASTROCYTES. Juvenile- and adult-onset types show progressive atrophy of the lower brainstem instead. De novo mutations in the GFAP gene are associated with the disease with propensity for paternal inheritance.
An intermediate filament protein found only in glial cells or cells of glial origin. MW 51,000.
One of the alpha crystallin subunits. In addition to being expressed in the lens (LENS, CRYSTALLINE), alpha-crystallin B chain has been found in a variety of tissues such as HEART; BRAIN; MUSCLE; and KIDNEY. Accumulation of the protein in the brain is associated with NEURODEGENERATIVE DISEASES such as CREUTZFELDT-JAKOB SYNDROME and ALEXANDER DISEASE.
A class of large neuroglial (macroglial) cells in the central nervous system - the largest and most numerous neuroglial cells in the brain and spinal cord. Astrocytes (from "star" cells) are irregularly shaped with many long processes, including those with "end feet" which form the glial (limiting) membrane and directly and indirectly contribute to the BLOOD-BRAIN BARRIER. They regulate the extracellular ionic and chemical environment, and "reactive astrocytes" (along with MICROGLIA) respond to injury.
Pathologic conditions affecting the BRAIN, which is composed of the intracranial components of the CENTRAL NERVOUS SYSTEM. This includes (but is not limited to) the CEREBRAL CORTEX; intracranial white matter; BASAL GANGLIA; THALAMUS; HYPOTHALAMUS; BRAIN STEM; and CEREBELLUM.
The age, developmental stage, or period of life at which a disease or the initial symptoms or manifestations of a disease appear in an individual.
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
A condition marked by raised intracranial pressure and characterized clinically by HEADACHES; NAUSEA; PAPILLEDEMA, peripheral constriction of the visual fields, transient visual obscurations, and pulsatile TINNITUS. OBESITY is frequently associated with this condition, which primarily affects women between 20 and 44 years of age. Chronic PAPILLEDEMA may lead to optic nerve injury (see OPTIC NERVE DISEASES) and visual loss (see BLINDNESS).
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
Increased pressure within the cranial vault. This may result from several conditions, including HYDROCEPHALUS; BRAIN EDEMA; intracranial masses; severe systemic HYPERTENSION; PSEUDOTUMOR CEREBRI; and other disorders.
A branch of internal medicine concerned with the diagnosis and treatment of INFECTIOUS DISEASES.
An important nosocomial fungal infection with species of the genus CANDIDA, most frequently CANDIDA ALBICANS. Invasive candidiasis occurs when candidiasis goes beyond a superficial infection and manifests as CANDIDEMIA, deep tissue infection, or disseminated disease with deep organ involvement.
Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.
Individuals licensed to practice medicine.
Inland bodies of still or slowly moving FRESH WATER or salt water, larger than a pond, and supplied by RIVERS and streams.

The clinicopathological spectrum of Rosenthal fibre encephalopathy and Alexander's disease: a case report and review of the literature. (1/47)

Alexander's disease is a leucodystrophy that usually presents in early childhood, but can infrequently arise in adults. It is characterised pathologically by megalencephaly, demyelination, and the presence of numerous Rosenthal fibres. Most cases have been shown to be due to mutations in the gene encoding glial fibrillary acidic protein. In rare instances, numerous Rosenthal fibres have been found at autopsy in patients who have suffered protracted debilitating systemic illnesses, some with associated brain stem signs, and in very rare instances in patients with no apparent neurological abnormality. The term "Rosenthal fibre encephalopathy" is used to distinguish these cases from those of Alexander's disease. We report the first case of Rosenthal fibre encephalopathy in a young man with AIDS, and review the literature.  (+info)

Alexander-disease mutation of GFAP causes filament disorganization and decreased solubility of GFAP. (2/47)

Alexander disease is a fatal neurological illness characterized by white-matter degeneration and the formation of astrocytic cytoplasmic inclusions called Rosenthal fibers, which contain the intermediate filament glial fibrillary acidic protein (GFAP), the small heat-shock proteins HSP27 and alphaB-crystallin, and ubiquitin. Many Alexander-disease patients are heterozygous for one of a set of point mutations in the GFAP gene, all of which result in amino acid substitutions. The biological effects of the most common alteration, R239C, were tested by expressing the mutated protein in cultured cells by transient transfection. In primary rat astrocytes and Cos-7 cells, the mutant GFAP was incorporated into filament networks along with the endogenous GFAP and vimentin, respectively. In SW13Vim(-) cells, which have no endogenous cytoplasmic intermediate filaments, wild-type human GFAP frequently formed filamentous bundles, whereas the R239C GFAP formed 'diffuse' and irregular patterns. Filamentous bundles of R239C GFAP were sometimes formed in SW13Vim(-) cells when wild-type GFAP was co-transfected. Although the presence of a suitable coassembly partner (vimentin or GFAP) reduced the potential negative effects of the R239C mutation on GFAP network formation, the mutation affected the stability of GFAP in cells in a dominant fashion. Extraction of transfected SW13Vim(-) cells with Triton-X-100-containing buffers showed that the mutant GFAP was more resistant to solubilization at elevated KCl concentrations. Both wild-type and R239C GFAP assembled into 10 nm filaments with similar morphology in vitro. Thus, although the R239C mutation does not appear to affect filament formation per se, the mutation alters the normal solubility and organization of GFAP networks.  (+info)

Gene expression analysis in mice with elevated glial fibrillary acidic protein and Rosenthal fibers reveals a stress response followed by glial activation and neuronal dysfunction. (3/47)

Alexander disease is a fatal neurodegenerative disorder resulting from missense mutations of the intermediate filament protein, GFAP. The pathological hallmark of this disease is the formation of cytoplasmic protein aggregates within astrocytes known as Rosenthal fibers. Transgenic mice engineered to over-express wild-type human GFAP develop an encephalopathy with identical aggregates, suggesting that elevated levels of GFAP in addition to mutant protein contribute to the pathogenesis of this disorder. To study further the effects of elevated GFAP and Rosenthal fibers per se, independent of mutations, we performed gene expression analysis on olfactory bulbs of transgenic mice at two different ages to follow the progression of pathology. The expression profiles reveal a stress response that includes genes involved in glutathione metabolism, peroxide detoxification and iron homeostasis. Many of these genes are regulated by the transcription factor Nfe2l2, which is also increased in expression at 3 weeks. An immune-related response occurs with activation of cytokine and cytokine receptor genes, complement components and acute phase response genes. These transcripts are further elevated with age, with additional induction of macrophage-specific markers such as Mac1 and CD68, suggesting activation of microglia. At 4 months, decreased expression of genes for microtubule-associated proteins, vesicular trafficking proteins and neurotransmitter receptors becomes apparent. Interneuron-specific transcription factors including Dlx family members and Pax6 are downregulated as well as Gad1 and Gad2, suggesting impairment of GABAergic granule cells. Together, these data implicate an initial stress response by astrocytes, which results in the activation of microglia and compromised neuronal function.  (+info)

Plectin regulates the organization of glial fibrillary acidic protein in Alexander disease. (4/47)

Alexander disease (AxD) is a rare but fatal neurological disorder caused by mutations in the astrocyte-specific intermediate filament protein glial fibrillary acidic protein (GFAP). Histologically, AxD is characterized by cytoplasmic inclusion bodies called Rosenthal fibers (RFs), which contain GFAP, small heat shock proteins, and other undefined components. Here, we describe the expression of the cytoskeletal linker protein plectin in the AxD brain. RFs displayed positive immunostaining for plectin and GFAP, both of which were increased in the AxD brain. Co-localization, co-immunoprecipitation, and in vitro overlay analyses demonstrated direct interaction of plectin and GFAP. GFAP with the most common AxD mutation, R239C (RC GFAP), mainly formed abnormal aggregates in human primary astrocytes and murine plectin-deficient fibroblasts. Transient transfection of full-length plectin cDNA converted these aggregates to thin filaments, which exhibited diffuse cytoplasmic distribution. Compared to wild-type GFAP expression, RC GFAP expression lowered plectin levels in astrocytoma-derived stable transfectants and plectin-positive fibroblasts. A much higher proportion of total GFAP was found in the Triton X-insoluble fraction of plectin-deficient fibroblasts than in wild-type fibroblasts. Taken together, our results suggest that insufficient amounts of plectin, due to RC GFAP expression, promote GFAP aggregation and RF formation in AxD.  (+info)

Neuropathology for the neuroradiologist: Rosenthal fibers. (5/47)

Distinctive intracellular structures known as inclusions may be occasionally observed on stained tissue preparations and may further suggest a specific diagnosis. Pathologists rely on these findings much as radiologists rely on findings revealed in the gray-scale patterns of densities and intensities on images. Appreciation of these inclusions can enhance the interactions of the neuroradiologist with the neuropathologist and deepen understanding of certain conditions. This report reviews the neuropathologically observed intracellular inclusions known as Rosenthal fibers in the context of Alexander disease and slow-growing tumors such as pilocytic astrocytoma.  (+info)

The Alexander disease-causing glial fibrillary acidic protein mutant, R416W, accumulates into Rosenthal fibers by a pathway that involves filament aggregation and the association of alpha B-crystallin and HSP27. (6/47)

Here, we describe the early events in the disease pathogenesis of Alexander disease. This is a rare and usually fatal neurodegenerative disorder whose pathological hallmark is the abundance of protein aggregates in astrocytes. These aggregates, termed "Rosenthal fibers," contain the protein chaperones alpha B-crystallin and HSP27 as well as glial fibrillary acidic protein (GFAP), an intermediate filament (IF) protein found almost exclusively in astrocytes. Heterozygous, missense GFAP mutations that usually arise spontaneously during spermatogenesis have recently been found in the majority of patients with Alexander disease. In this study, we show that one of the more frequently observed mutations, R416W, significantly perturbs in vitro filament assembly. The filamentous structures formed resemble assembly intermediates but aggregate more strongly. Consistent with the heterozygosity of the mutation, this effect is dominant over wild-type GFAP in coassembly experiments. Transient transfection studies demonstrate that R416W GFAP induces the formation of GFAP-containing cytoplasmic aggregates in a wide range of different cell types, including astrocytes. The aggregates have several important features in common with Rosenthal fibers, including the association of alpha B-crystallin and HSP27. This association occurs simultaneously with the formation of protein aggregates containing R416W GFAP and is also specific, since HSP70 does not partition with them. Monoclonal antibodies specific for R416W GFAP reveal, for the first time for any IF-based disease, the presence of the mutant protein in the characteristic histopathological feature of the disease, namely Rosenthal fibers. Collectively, these data confirm that the effects of the R416W GFAP are dominant, changing the assembly process in a way that encourages aberrant filament-filament interactions that then lead to protein aggregation and chaperone sequestration as early events in Alexander disease.  (+info)

Synergistic effects of the SAPK/JNK and the proteasome pathway on glial fibrillary acidic protein (GFAP) accumulation in Alexander disease. (7/47)

Protein aggregates in astrocytes that contain glial fibrillary acidic protein (GFAP), small heat shock proteins, and ubiquitinated proteins are termed Rosenthal fibers and characterize Alexander disease, a leukodystrophy caused by heterozygous mutations in GFAP. The mechanisms responsible for the massive accumulation of GFAP in Alexander disease remain unclear. In this study, we show that overexpression of both wild type and R239C mutant human GFAP led to cytoplasmic inclusions. GFAP accumulation also led to a decrease of proteasome activity and an activation of the MLK2-JNK pathway. In turn, the expression of activated mixed lineage kinases (MLKs) induced JNK activation and increased GFAP accumulation, whereas blocking the JNK pathway decreased GFAP accumulation. Activated MLK also inhibited proteasome function. A direct inhibition of proteasome function pharmacologically further activated JNK. Our data suggest a synergistic interplay between the proteasome and the SAPK/JNK pathway in the context of GFAP accumulation. Feedback interactions among GFAP accumulation, SAPK/JNK activation, and proteasomal hypofunction cooperate to produce further protein accumulation and cellular stress responses.  (+info)

A case of infantile Alexander disease accompanied by infantile spasms diagnosed by DNA analysis. (8/47)

Alexander disease (AD) is a rare leukodystrophy of the central nervous system of unknown etiology. AD is characterized by progressive failure of central myelination and the accumulation of Rosenthal fibers in astrocytes, and is inevitably lethal in nature. Symptomatically, AD is associated with leukoencephalopathy with macrocephaly, seizures, and psychomotor retardation in infants, and usually leads to death within the first decade. Its characteristic magnetic resonance imaging (MRI) findings have been described as demyelination predominantly in the frontal lobe. Moreover, dominant mutations in the GFAP gene, coding for glial fibrillary acidic protein (GFAP), a principal astrocytic intermediate filament protein, have been shown to lead to AD. The disease can now be detected by genetic diagnosis. We report the Korean case of an 8-month-old male patient with AD. He was clinically characterized due to the presence of psychomotor retardation, megalencephaly, spasticity, and recurrent seizures including infantile spasms which is a remarkable presentation. Demyelination in the frontal lobe and in a portion of the temporal lobe was demonstrated by brain MRI. Moreover, DNA analysis of peripheral blood showed the presence of a R239L mutation in the GFAP gene, involving the replacement of guanine with thymine.  (+info)

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BACKGROUND: We studied a family including two half-siblings, sharing the same mother, affected by slowly progressive, adult-onset neurological syndromes. In spite of the diversity of the clinical features, characterized by a mild movement disorder with cognitive impairment in the elder patient, and severe motor-neuron disease (MND) in her half-brother, the brain Magnetic Resonance Imaging (MRI) features were compatible with adult-onset Alexanders disease (AOAD), suggesting different expression of the same, genetically determined, condition.METHODS: Since mutations in the alpha isoform of glial fibrillary acidic protein, GFAP-α, the only cause so far known of AOAD, were excluded, we applied exome Next Generation Sequencing (NGS) to identify gene variants, which were then functionally validated by molecular characterization of recombinant and patient-derived cells.RESULTS: Exome-NGS revealed a mutation in a previously neglected GFAP isoform, GFAP-ϵ, which disrupts the GFAP-associated ...
Alexander disease is a rare disorder resulting from a glial fibrillary acidic protein gene mutation which causes progressive degeneration of white matter. With the usual poor prognosis, there are few case reports with long-term follow-up. We report the five-year clinical course of Alexander disease in one case using serial magnetic resonance imaging. A 12-month-old Japanese male was referred to the pediatrics department in our hospital because of developmental retardation. Alexander disease was diagnosed by gene examination of the mutation of a glial fibrillary acidic protein. Magnetic resonance imaging findings showed abnormalities in white matter, deep gray matter, and medulla oblongata. Serial magnetic resonance imaging examinations until the age of five were performed and changes in magnetic resonance imaging findings were compared to the progression in clinical symptoms. Alexander disease is a very rare disease with a variety of clinical phenotypes. Therefore serial magnetic resonance imaging
Alexander disease, also known as fibrinoid leukodystrophy, is a progressive and fatal neurodegenerative disease. It is a rare genetic disorder and mostly affects infants and children, causing developmental delay and changes in physical characteristics. Delays in development of some physical, psychological and behavioral skills; progressive enlargement of the head (macrocephaly), seizures, spasticity, and in some cases also hydrocephalus, idiopathic intracranial hypertension, and dementia. Alexander disease is a genetic disorder affecting the midbrain and cerebellum of the central nervous system. It is caused by mutations in the gene for glial fibrillary acidic protein (GFAP) that maps to chromosome 17q21. It is inherited in an autosomal dominant manner, such that the child of a parent with the disease has a 50% chance of inheriting the condition, if the parent is heterozygotic. However, most cases arise de novo as the result of sporadic mutations. Alexander disease belongs to leukodystrophies, a ...
Alexander disease is a leukodystrophy, a group of more than 15 rare genetic disorders that cause progressive degeneration of the white matter of the brain due…
Alexander disease Labrador retriever type (Leukodystrophy) is a rare neurodegenerative disorder characterized by astrocyte dysfunction.
Palatal tremor is essential (EPT), where isolated, or symptomatic (SPT), where part of a symptom complex. SPT is reported with lesions in the dentato-rubro-olivary pathway and in neurodegenerative and genetic disorders. Some patients have the poorly understood progressive ataxia and palatal tremor (PAPT).. We report a series of twelve patients with SPT. Two have been diagnosed with multi-system atrophy without pathological confirmation. Two have vascular disease affecting the dentato-rubro-olivary pathway. One has mutation-proven Alexander Disease. The remaining seven are all male and classified as sporadic PAPT.. The age range at symptom onset is 36-87 years (36-80 in the PAPT group). All twelve have ataxia. Of the PAPT group, five of seven (71%) have dysarthria. Two PAPT patients had normal DAT scans, and two tested negative for POLG1 and Alexander Disease. Eleven of the twelve (except the Alexander Disease patient) had bilateral olivary hypertrophy on brain MRI.. Palatal tremor is often ...
Alexander McQueen was the famous fashion clothes designer,his own brand is Alexander McQueen Outlet Shop,it sells mens fashion, womens fashion, sportswear, sports goods, denim, leather accessories, accessories, perfumes, home accessories, etc. Alexander McQueen advocated independence and strength, with extraordinary and dramatic design, and he was famous for his designing inspirated for horror master Hitchcock film actress. Since Alexander McQueen died after the tragic death, his long-time partner Sarah Burton took over the London brand, and became famous for taking responsible for the Princess Kates wedding honorably.And the stars and royalties seek after the brand . On November 4, cheap Alexander McQueen sale set foot in China finally for the first time. The Fourteenth Alexander McQueen store recently opened in Beijing. In China, there were a number of Alexander McQueen Scarf Outlet,Alexander McQueen Shoes,Alexander McQueen Jackets Outlet sold. ...
TY - JOUR. T1 - αB-crystallin and 27-kd heat shock protein are regulated by stress conditions in the central nervous system and accumulate in Rosenthal fibers. AU - Iwaki, T.. AU - Iwaki, A.. AU - Tateishi, J.. AU - Sakaki, Y.. AU - Goldman, J. E.. PY - 1993/12/1. Y1 - 1993/12/1. N2 - To understand the significance of the accumulation of αB-crystallin in Rosenthal fibers within astrocytes, the expression and metabolism of αB- crystallin in glioma cell lines were examined under the conditions of heat and oxidative stress, αB-crystallin mRNA was increased after both stresses, and αB-crystallin protein moved from a detergent-soluble form. In addition, Western blotting of Alexanders disease brain homogenates revealed that the 27-kd heat shock protein (HSP27), which is related to αB-crystallin, accumulates along with αB-crystallin. The presence of HSP27 in Rosenthal fibers was directly demonstrated by immunohistochemistry. Our results suggest that astrocytes in Alexanders disease may be ...
Alexander disease, a Leukodystrophy, is a progressive and fatal neurological disorder in which the destruction of white matter in the brain is accompanied by the formation of abnormal deposits known as Rosenthal fibers. Rosenthal fibers are aggregations of protein that occur in astrocytes, one of the so-called glial cells of the central nervous system. These aggregates are found occasionally in other disorders, but not with the abundance or particular distribution in the brain that occurs in Alexander disease.. The age of onset is quite variable, ranging from prenatal through the sixth decade. The most common classification divides patients into three categories based on age of onset, infantile (0-2 years), juvenile (2-12 years), and adult (,12 years). More recently, a different classification has been proposed, with only two categories of type I and type II, with the distinction hinging more on distribution of lesions and clinical presentation rather than age of onset (all type I cases being ...
Alexander appeared on every cycle of the television program Americas Next Top Model as the runway coach to the contestants. He was made a judge starting with Cycle 5. As of Cycle 14 of the show, Alexander was replaced as a permanent judge on the panel by Vogue editor at large André Leon Talley.[9] Alexander stayed on as the shows runway coach and has appeared in many of the international versions of the show.[10]. Alexanders nickname Miss J, or lovingly Siss J after the word sister came from Cycle 1 contestant Robin Manning, who often confused Alexander and Jay Manuel and on several occasions referred to Alexander as Miss J by accident because of his flamboyant clothing (Alexander often dresses in drag and usually wears a skirt and high heels during runway walking training) and personality. Accordingly, Jay Manuel is referred to as Mr. Jay, and ANTM contestants often call them The Jays, The Two Jays or Mr. and Ms. Jay when they appear together.[11] In 2008, the Jays were cast ...
Alexander disease is a rare, progressive, and generally fatal neurological disorder that results from dominant mutations affecting the coding region of GFAP, the gene encoding glial fibrillary acidic protein, the major intermediate filament protein of astrocytes in the central nervous system. A key step in pathogenesis appears to be the accumulation of GFAP protein within astrocytes to excessive levels. Studies using mouse models indicate that the severity of the phenotype correlates with the level of expression, and suppression of GFAP expression and/or accumulation is one strategy that is being pursued as a potential treatment. With the goal of identifying biomarkers that indirectly reflect the levels of GFAP in brain parenchyma, we have assayed GFAP levels in two body fluids in humans that are readily accessible as biopsy sites - cerebrospinal fluid and blood. We find that GFAP levels are consistently elevated in the CSF of Alexander disease patients, but only occasionally and modestly in ...
A slowly progressive and ultimately fatal brain disorder that most commonly occurs in children. The infantile form of the disease is characterized by megalencephaly (an abnormally large head), seizures, spasticity and developmental retardation.…
The #1 New York Times bestselling account of a neurosurgeons own near-death experience-for readers of 7 Lessons from Heaven. Thousands of people have had near-death experiences, but scientists have argued that they are impossible. Dr. Eben Alexander was one of those scientists. A highly trained neurosurgeon, Alexander knew that NDEs feel real, but are simply fantasies produced by brains under extreme stress.Then, Dr. Alexanders own brain was attacked by a rare illness. The part of the brain that controls thought and emotion-and in essence makes us human-shut down completely. For seven days he lay in a coma. Then, as his doctors considered stopping treatment, Alexanders eyes popped open. He had come back. Alexanders recovery is a medical miracle. But the real miracle of his story lies elsewhere. While his body lay in coma, Alexander journeyed beyond this world and encountered an angelic being who guided him into the deepest realms of super-physical existence. There he met, and spoke with, the Divine
The Peripatetic philosopher Alexander was known to posterity as the commentator on Aristotle, until Averroes took over this title. His commentaries eclipsed most of those of his predecessors, which now survive only in scattered quotations. Used by Plotinus, Alexanders commentaries were the basis for subsequent work on Aristotle by Neoplatonist commentators, and even though some themselves survive only in quotations by these later writers, Alexanders interpretations of particular passages are still helpful and are cited by commentators today.. In addition to Alexanders commentaries we have a number of monographs, and also collections of short discussions which are connected with themes in his writings, though some are probably by pupils rather than by Alexander himself. Alexanders most influential and controversial doctrine has been his interpretation of Aristotles theory of soul and intellect; regarding the soul as the product of the mixture of the bodily elements, he has been seen as ...
Introduction. Alexander Fleming Antibiotics One sometimes finds what one is not looking for. Sir Alexander Fleming 1. Alexander Fleming biography 2. The discovery of Penicillin 3. Purification to a stable form and industrial scale production 4. How an antibiotic work 5. Antibiotic resistance 1. Alexander Fleming 1881 - 1955 Alexander Fleming was born in a lonely, rural part of Scotland as the seventh of eight siblings and half-siblings, his family worked an 800-acre farm far away from the nearest house. The Fleming children spent much of their time in the streams, valleys, and moors of the countryside. We unconsciously learned a great deal from nature, said Fleming. When their father died, his eldest son took over the running of the farm. Another brother Tom had studied medicine and was opening a practice in London. Soon, inspired by their brother, four Fleming brothers and a sister were living together in London. Alec, as Alexander was called, had moved to London when he was around 14, and ...
Alexander chisel, 4 mm wide, stainless steel, 18 cm. Alexander chisel, 6 mm wide, stainless steel, 18 cm. Alexander chisel, 8 mm wide, stainless steel, 18 cm. Alexander chisel, 10 mm wide, stainless steel, 18 cm. Alexander chisel, 12 mm wide, stainless steel, 18 cm. Alexander chisel, 14 mm wide, stainless steel, 18 cm. ...
The Dodgers have agreed to terms with left-hander Scott Alexander on a one-year, $875K contract to avoid arbitration, reports Bob Nightengale of USA Today (via Twitter). Alexander falls a bit shy of his $1MM projected salary.. The 30-year-old looked like a potential non-tender candidate, perhaps explaining his decision to settle for slightly less than expected. An integral part of the Los Angeles bullpen in 2018, Alexander was limited to just 28 games last season, none after June 5. Alexander suffered a season-ending forearm issue in his throwing arm, which culminated in surgery to relieve nerve irritation in September.. Alexanders time in LA has been a bit of a mixed bag. Over the past two years, hes given the Dodgers 83.1 innings with a 3.67 ERA and mediocre strikeout (18.9%) and walk (9.9%) rates. Alexanders an elite ground-ball specialist, though. His 68.5% ground ball rate the past two seasons trails only Zack Britton among still-active pitchers (minimum 50 innings). The former ...
1]3,349 words. Oliver Stones Alexander is, well, great. It isnt perfect, but neither was Alexander. It is definitely worth seeing. But there is a subtle and sinister thread of anti-White propaganda running through the movie, and I would not recommend it to anyone without warning him first.. There are many reasons why I enjoyed Alexander. Chief among them is Alexander himself. Alexander the Great was surely one of the most gifted men in history. His father, Philip II, was the king of Macedon and the conqueror of Greece. Alexander was handsome and athletic. He was highly intelligent and received a remarkable education (Aristotle was one of his tutors). As a genius of military and political strategy, he was almost without rival. He was also an eloquent speaker and a charismatic leader of men. He was courageous, sharing the hardships of his soldiers and leading them into battle. He was capable of great acts of magnanimity to his enemies and generosity to his friends. He became the richest man the ...
I have just finished reading a book about the life and times of Alexander The Great (Alexander The Great by Robin Lane Fox. Published by Penguin Book. ISBN 0-141-02076-8).. I have recently read a number of different books about Alexander but this one, in particular, kept me going throughout. It was interesting and factual without being condescending. This book doesnt try to paint Alexander as either Great or the Devil but as truly a man who set out to exert some degree of revenge but ended up having travelled from the Mediterranean to the Indian Ocean and was, arguably, the first true explorer.. This man not only trod the path of being an explorer but was a conqueror who took with him thousands of followers who also fought battles, disease, distance, hunger, thirst and the geography to travel the miles with him.. Alexander may or may not have been The Great but he was truly remarkable. I am glad to have found and read this book.. ...
Understanding that poor posture is something we teach ourselves, its also important to be aware that it can also be unlearned, by incorporating the right techniques.. The Alexander Technique is integral to correcting poor posture and alleviating the physical effects caused by incorrect body alignment. Rather than being defined as a medical practice, Alexander Technique could be described as a body and mind educational training methodology that teaches you how to achieve optimal coordination and alignment for your individual body shape, by rediscovering better postural techniques.. While you may not have heard of this form of postural training before, it was initially introduced by founder Frederick Matthias Alexander in the 1890s. In conjunction with realigning posture, training in Alexander Technique also helps you avoid unnecessary muscular and mental tension.. Alexander Technique is a preferred training methodology to help prevent musicians injuries and has been known to have positive ...
Alexander disease (ALXD) is a rare demyelinating disease of the white matter of the brain that is caused by a mutation in the glial fibrillary acidic protein (GFAP) gene. The overexpression of GFAP in astrocytes induces a failure in the developmental growth of the myelin sheath. The neurodegenerative destruction of the myelin sheath of the white matter is accompanied by an accumulation of abnormal deposits of Rosenthal fibers in astrocytes, which is the hallmark of ALXD. The disease can be divided into four groups based on the onset age of the patients: neonatal, infantile, juvenile, or adult. Early-onset disease is more severe, progresses rapidly, and results in a shorter life span than late-onset cases. Magnetic resonance imaging and genetic tests are mostly used for diagnostic purposes. Pathological tests of brain tissue for Rosenthal fibers are definitive diagnostic methods. Therapeutic strategies are being investigated. Ceftriaxone, which is an enhancer of glial glutamate transporter ...
Bergfield, K.L., Hanson, K.D., Chen, K., Teipel, S.J., Hampel, H., Rapoport, S.I., Moeller, J.R., & Alexander, G.E. (2010). Age-related networks of regional covariance in MRI gray matter: Reproducible multivariate patterns in healthy aging. Neuroimage, 49, 1750-9. PMID: 19796692. Alexander, G.E., Bergfield, K.L., Chen, K., Reiman, E.M., Hanson, K.D., Lin, L., Bandy, D., Caselli, R.J., & Moeller, J.R. (2012). Gray matter network associated with risk for Alzheimers disease in young to middle-aged adults. Neurobiology of Aging, 33, 2723-32. PMID: 22405043. Alexander, G.E., Ryan, L., Bowers, D., Foster, T.C., Bizon, J.L., Geldmacher, D.S., & Glisky, E.L. (2012). Characterizing cognitive aging in humans with links to animal models. Frontiers in Aging Neuroscience, 4, 21. PMID: 22988439. Raichlen, D.A., & Alexander G.E. (2014). Exercise, APOE genotype, and the evolution of the human lifespan. Trends in Neurosciences, 37, 247-55. (Article featured on journal cover, May, 2014.) PMID: 24690272. Nguyen, ...
https://twitter.com/#!/CCSVI_Society Dr. Alexander (endothelial biologist) now presenting MS and cerebral endothelial dysfunctionDr. Alexander: endothelium becomes sticky with shear: activates leukocytes into brain parenchyma Dr. Alexander: endothelial cells very sensitive to glycemic (glucose) and oxidative stressDr. Alexander: Interferon beta may have ...
Grace Hazel SHOWERS ALEXANDER - Yavapai County Arizona - Grace H. (Showers) Alexander - Young b. Aug. 13, 1874, Whitneys Point, N. Y. d. Nov. 8, 1934, Prescott, Az. COD: Cerebral Hemorrhage w/o John H. Alexander (m) May 27, 1903, Little Ash Creek, Az. Territory w/o James B. Young d/o Daniel & Phebe (Holt) Showers Note: resided in Az. 50 years
Genetic genealogy is the new frontier. Our two DNA views are designed to help you use genetic testing to confirm and expand Alexanders genealogy. The DNA Ancestors page shows the specific ancestors from whom Alexander gets his Y chromosome and mitochondrial DNA. Especially helpful for some serious genetic genealogists is the inheritance pattern for Alexanders X chromosome, also shown here. The DNA Descendants page shows exactly who has inherited Alexanders testable DNA. DNA Ancestor Confirmation Aid ...
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Alexander, S. and Udayakumar, V. and Gayathri, V. (2012) Catalytic activity of a supported palladium-benzimidazole complex toward alkene hydrogenation. Transition Metal Chemistry, 37 (4). pp. 367-372. ISSN 1572-901X Alexander, S. and Udayakumar, V. and Gayathri, V. (2012) Synthesis and characterisation of a polymer-bound rhodium-benzimidazole complex as catalyst for the hydrogenation of nitroarenes. Transition Metal Chemistry, 37 (1). pp. 1-6. ISSN 1572-901X Udayakumar, V. and Alexander, S. and Gayathri, V. and Shivakumaraiah, . and Viswanathan, B. (2011) Study on the influence of substituents upon the hydrogenation of nitrobenzene using a polymer-supported palladium-imidazole complex catalyst. Reaction Kinetics, Mechanisms and Catalysis, 103 (2). pp. 341-352. ISSN 1878-5204 Alexander, S. and Udayakumar, V. and Nagaraju, N. and Gayathri, V. (2010) Hydrogenation of substituted nitroarenes by a polymer-bound palladium(II) Schiff base catalyst. Transition Metal Chemistry, 35 (2). pp. 247-251. ISSN ...
The use of imagery to teach or learn the Alexander Technique is, to put it mildly, a controversial topic.. The diverse views were on full display in recent exchanges on the Alexander Technique Forum Facebook Page(1) include everything from general disapproval of using images to endorsement in some or many teaching situations.. Some members have also pointed out that a teachers verbal instructions can generate mental images in a students mind, so the distinction between using words while teaching - which has a long history in Alexander Technique teaching - and using images isnt always clear.. Personally, Ive had mixed results with using mental images.. While I was training in England, I had a great many lessons from a remarkable teacher (not connected to my training course) who used the string pulling your head up image during lessons.. On the plus side, that image did get me out of my hips in a way Id never before experienced, and the teachers on my training course, who knew nothing ...
In Alexanders company was a professional historian named Callisthenes of Olynthus (c.370-327), who had already published a Greek history of the years 387-356. The two men may have met as members of the circle around the Macedonian philosopher Aristotle of Stagira, who was an uncle of the historian and the teacher of the future king. During the campaign, Callisthenes main duty was to write the Deeds of Alexander, but he was also sent on scientific missions. When Alexander was in Egypt, he sent his historian to Nubia, where he discovered the cause of the Nile flood; and in Babylon, Callisthenes supervised the translation of the Astronomical diaries, which were used by Callipus of Cyzicus to reform the Greek calendars.. In the summer of 327, Callisthenes voiced protests against the introduction of proskynesis (an aspect of the Persian court ritual) among the Macedonians, and lost Alexanders favor (more...). It is not clear what happened to Callisthenes: Aristobulus and Ptolemy, officers who were ...
View a growing collection of short video clips showing Marjs teaching toward the end of her life. Additional video of Marj teaching in 1991 (courtesy of Barry Kantor). Short excerpt from that video. When most of these last videos were shot in 1990 ,1991 and 1992, Marj was well over 90 and suffering from severe osteoporosis which limited her ability to reach her full height. Despite that, her movements were as fluid as ever. In Alexander Technique jargon, her conditions of use had diminished with age, but her manner of use - and with that, the power and clarity of her touch - was at its peak.* During this workshop, she taught for 6 hours a day - mostly standing on her feet - for seven straight days!). ***. Marjorie filmed a gathering of students on F. Matthias Alexanders first Alexander Technique training course in London in the early 1930s. She was probably using the same camera she used in an earlier trip to England with her sister to study with Alexander - the first home movie camera sold in ...
VINTAGE - MADAME ALEXANDER - SWEET VIOLET 18 - BENT ELBOWS + KNEES + A WALKER. This is an Sweet Violet doll 18 tall… She has bent elbows and bent knees and her head turns when you move her feet…. She is a WALKER…. She is a wonderful doll to have…. She is tagged in back of dress…. Made for a short period of time…. Very hard to find her in this wonderful condition… Oh, doll stand not included.. I like Happy Collections!!! Feedback will be left and is appreciated at your earliest convenience. The item VINTAGE MADAME ALEXANDER SWEET VIOLET 18 BENT ELBOWS + KNEES + A WALKER is in sale since Wednesday, March 14, 2018. This item is in the category Dolls & Bears\Dolls\By Brand, Company, Character\Madame Alexander\Vintage (Pre-1973)\1948-59″. The seller is rasyiftime and is located in Sacramento, California. This item can be shipped to United States. ...
Joseph Alexander, clergyman and educator, born in Cecil County, Md., was the son of Theophilus and Catherine Alexander and grandson of James and Margaret McKnitt Alexander. His mothers maiden name is believed to have been Wallis. He had a brother, George, and five sisters, Margaret, Sophia, Heziah, Ann and Catrine. Theophilus was an affluent blacksmith who reared and educated his children in the strict Calvinist tradition. Joseph was sent to Nottingham Academy at Colora, Md., where in 1759 he, Thomas Ruston, and Benjamin Rush were recommended by the head of the school for entrance to Nassau Hall (later Princeton University). At Nassau, from which Alexander was graduated in the class of 1760, he met and married Martha Esther Davies, daughter of Samuel Davies, the president of the college. For the next several years he applied himself to the study of theology, having chosen the Presbyterian ministry as a profession, and in 1767 he was licensed by Newcastle Presbytery. In the same year he moved to ...
Alexander disease (AxD) is a primary genetic disorder of astrocytes caused by dominant mutations in the gene encoding the intermediate filament (IF) protein GFAP. This disease is characterized by excessive accumulation of GFAP, known as Rosenthal fibers, within astrocytes.
Bacterial diversity analysis of moderately thermophilic microflora enriched by different energy sources In this study, cultures grown from explants of rabbit rib perichondrium were exposed to exogenously added transforming growth factor-beta 1 at concentrations of 0.1-10 ng/ml of media. Correlations with the Short Form-36 were used to investigate the convergent validity. Antioxidant status in ceftin dogs with idiopathic dilated cardiomyopathy. The pathological hallmark of Alexander disease is the inclusion body, known as Rosenthal fiber, within the cell bodies and processes of astrocytes. Although IL-4, IL-5, IL-10, and IL-13 each regulate distinct aspects of the granulomatous inflammatory response, IL-13 was identified as the primary mediator of liver fibrosis. Acute effect of whole body vibration on postural control in congenitally blind subjects: clarithromycin a preliminary evidence. Heterokaryons have been utilized for complementation and dominance testing of mutations that affect ...
P,A main neurogenic niche in the adult human brain is the subventricular zone (SVZ). Recent data suggest that the progenitors that are born in the human SVZ migrate via the rostral migratory stream (RMS) towards the olfactory bulb (OB), similar to what has been observed in other mammals. A subpopulation of astrocytes in the SVZ specifically expresses an assembly-compromised isoform of the intermediate filament protein glial fibrillary acidic protein (GFAP-delta). To further define the phenotype of these GFAP-delta expressing cells and to determine whether these cells are present throughout the human subventricular neurogenic system, we analysed SVZ, RMS and OB sections of 14 aged brain donors (ages 74-93). GFAP-delta was expressed in the SVZ along the ventricle, in the RMS and in the OB. The GFAP-delta cells in the SVZ co-expressed the neural stem cell (NSC) marker nestin and the cell proliferation markers proliferating cell nuclear antigen (PCNA) and Mcm2. Furthermore, BrdU retention was found ...
Glial fibrillary acidic protein (GFAP), a 50 kDa protein, is a major intermediate filament protein in mature astrocytes. It is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in the GFAP gene in humans cause Alexander disease, a very rare, fatal neurodegenerative disease that mostly affects infants and children and results in developmental delay and changes in physical characteristics. GFAP is also known as FLJ45472.. ...
Glial fibrillary acidic protein (GFAP), a 50 kDa protein, is a major intermediate filament protein in mature astrocytes. It is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in the GFAP gene in humans cause Alexander disease, a very rare, fatal neurodegenerative disease that mostly affects infants and children and results in developmental delay and changes in physical characteristics. GFAP is also known as FLJ45472.. ...
Thirdly the Alexander Technique may improve the cerebellum, an area of the brain that has been linked with dyslexia and ADD, especially by Dore Centres / DDAT. The main role of the cerebellum is coordination of thoughts and actions, something which is often poor in children with learning difficulties. Through the Alexander Technique you learn to move your body in a controlled manner which requires you to learn a level of mental discipline. It should not be forgotten that the body is a very complex organism that is sending many different pieces of information to the brain: How hot am I? Where are my legs? What can my fingers feel? Do I need to go to the toilet? With all this information rushing into the brain, swamping the under-developed cerebellum, its conceivable that as a coping strategy the brain just ignores it. This could give rise to the clumsiness and inattentive behavior as the child is ignoring the signals the body sends it. With the Alexander Technique, it possible to become aware of ...
23 May 2014. The federal member for Bennelong, John Alexander, is encouraging locals to join an army of volunteers with just the click of a button.. Mr Alexander is hosting his own portal on the DoSomethingNearYou website.. Those looking to become involved in volunteer projects can visit: dosomethingnearyou.com.au/john-alexander, enter their postcode or suburb, and receive a list of projects or community groups to become involved with.. Through my portal volunteers can sign up for their local SES or Rural Fire Service, donate blood to the Red Cross, assist the RSPCA, join their local Rotary or Lions Club or help with myriad other programmes and projects, said Mr Alexander. About a third of the adult Australian population is involved in volunteering - but I believe this percentage could be higher.. Volunteers are the heart and soul of our community, our welfare organisations, our schools and our sporting clubs. The gift of time is one of the most precious gifts you can offer your community - ...
Michael J. Alexander, MD, has led and participated in numerous research projects funded by the National Institutes of Health (NIH) and industry. Over the past five years, his clinical research has focused on four primary areas: brain aneurysms (for example, Alexander was the institutional principal investigator for the Liberty trial and the FRED flow diverter trial), atherosclerotic disease (cholesterol plaque) of the carotid arteries and cerebral arteries (Alexander was a leader on the initial steering committee of the NIH-funded SAMMPRIS trial, was the institutional principal investigator on the SAPPHIRE WW carotid stent trial, and was the national principal investigator for the WEAVE intracranial stent trial), acute embolic stroke (he was co-investigator of the NIH-funded MR Rescue stroke trial and institutional principal investigator for the POSITIVE, THERAPY, START and PICS stroke trials), and cerebral (brain) hemorrhage (he was co-investigator in the NIH-funded MISTIE 3 and CLEAR 3 ...
THE #1 NEW YORK TIMES BESTSELLING ACCOUNT OF A NEUROSURGEONS OWN NEAR-DEATH EXPERIENCE.Internationally acclaimed neurosurgeon Dr Eben Alexander always considered himself a man of science. His unwavering belief in evidence-based medicine fuelled a career in the top medical institutions of the world. But all this was set to change. One morning in 2008 he fell into a coma after suffering a rare form of bacterial meningitis. Scans of his brain revealed massive damage. Death was deemed the most likely outcome. As his family prepared themselves for the worst, something miraculous happened. Dr Alexanders brain went from near total inactivity to awakening. He made a full recovery but he was never the same. He woke certain of the infinite reach of the soul, he was certain of a life beyond death. In this astonishing book, Dr Alexander shares his experience, pieced together from the notes he made as soon as he was able to write again. Unlike other accounts of near-death experiences, he is able to explain in
Alexander has participated in many organizations to improve the living conditions for women and children, including: Rainbow Coalition, Center for Constitutional Rights, Reproductive Rights National Network, Planned Parenthood, City Material and Child Health. In 1978, she established the Coalition to Fight Infant Mortality in Oakland, which helped women with medical care and social issues. In 2000, Alexander began the Black Infant Health program in Berkeley, which grew from her coalition at Highland Hospital. This was the foundational step to the creation of the Alameda County Coalition to decrease infant mortality. Alexander is also the current founder and board president of Healthy Black Families (HBF), Inc., which dovetails with the Black Infant Health program. It was founded as a non-profit organization in July 2013 to support the health, growth, development, and future of Black individuals and families. For her devotion towards health and social justice, Dr. Vicki has won many awards, ...
With Rockets owner Leslie Alexander announcing his first investment in China, a lease in the World City of Beijing development, and an advertising sponsorship with World City in Toyota Center, he was not the first member of the organization benefiting from the Yao Ming connection. Chuck Hayes (Li Ning) and Shane Battier (Peak) endorse Chinese basketball shoes. World City is the fifth company (of 22) with camera visible signage in Toyota Center. Battier had a 72-hour visit to Beijing before training camp and has a commercial that runs in China with a tour planned for next summer. Rockets owner Leslie Alexander laughed at the reports that his ex-wife Nanci Alexander, an avid animal rights activist, played a part in the NBA move to a synthetic basketball. Tracy McGradys concussion on Saturday might have knocked out some of his memory, but it brought back unhappy memories for Rockets forward Shane Battier. On Wednesday, the Rockets set or matched their season highs for points (118), first-quarter
RJ Fleck holds advanced degrees from the Universities of Toronto, California, and Stanford University in music performance, composition, computer science and digital audio engineering. He is an accomplished pianist, teaches music and managed a small digital audio research lab and residency (Mackenzie Post Digital) from his home in the Little Portugal neighbourhood of downtown Toronto for many years.. For the last several years, he has been increasingly devoting time to somatic and embodiment practices such as the Alexander Technique, Pilates, Tai Chi, Yoga and Vipassana Meditation. He completed certification at the Susan Sinclair Alexander Technique and Pilates Centre as a teacher of the Alexander Technique in 2007 and as an instructor of the Pilates Method in 2009. He certified as an instructor of Yoga with Octopus Garden in 2012.. ...
Struck in the name of King Philip III Arrhidaeus, Alexander the Greats half-brother, under the regent Perdikkas. Philip III and Alexanders infant son, Alexander IV, were made joint kings after Alexanders death. Philip was the bastard son of Philip II and a dancer, Philinna of Larissa. Alexander the Greats mother, Olympias, allegedly poisoned her stepson Philip III as a child, leaving him mentally disabled, eliminating him as a rival to Alexander. Neither Philip III nor Alexander IV was capable of actual rule and both were selected only to serve as pawns. The regents held power, while Philip III was actually imprisoned. In 317, Philip was murdered by Olympias to ensure the succession of her grandson.GS87632. Silver tetradrachm, Price P182, M ller Alexander P103, Demanhur 4601, SNG Munchen 969, SNG Cop 1077, SNG Saroglos -, VF, high relief, centered on a tight flan, rose toning, scratches and marks, some porosity, weight 16.902 g, maximum diameter 26.9 mm, die axis 270o, Mesopotamia, Babylon ...
Johns Thoughts: Not sure why Goldust is a 205 Live mainstay now. He even wrestled on this show. Are they building towards a Goldust and Cedric Alexander program because I dont think that would be the worst thing in the world with Goldust going back to that promising throwback heel character and Cedric needing some sort of character development. I would roll my eyes a bit at Cedric essentially taking the place of Ron Killings in this feud.. Enzo Amore made his entrance selling his injuries. He did his usual speech and the crowd wasnt as participatory to start but eventually the cheers built up. Enzo built up Tony Nese and called him Tony Abs. Nese then did his unnecessarily long ass entrance while cutting his hard to hear his usual promo without a microphone. Cedric Alexander made his entrance to his remixed theme music. Its the same lyrics but theyve done some work editing the background music to the vocals…. 2. Tony Nese (w/Enzo Amore) vs. Cedric Alexander. Ugh. Tony Nese took steps ...
al-bū-mĭ-noo′rē-ă) [albumen + -uria] The presence of easily detectable amounts of albumin in the urine. Albuminuria is a common sign of renal impairment, e.g., nephrotic syndrome; it also occurs in fever, malignant hypertension, and in healthy people after vigorous exercise. SEE: microalbuminuria; nephritis; nephrosis. albuminuretic (al-bū-mĭ-noo-rĕt″ik), adj. albuminuric (al-bū -mĭ-noor′ik), adj. ...
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Thursday mornings with Angela Leidig. 9:15-10:15. Maximum Enrollment: 4. Location: The Armory, 191 Highland Ave, Somerville. Free parking behind the building and on the street. By donation. Click here to sign up for a class.. Topics to be addressed: The Alexander Technique approach to daily living including: pain, posture, sitting, stress, fitness, decision making, playing an instrument, and other issues people bring to the class. The focus of each class is determined by the interests and needs of the individuals attending.. What is the Alexander Technique?. The Alexander Technique helps people with chronic or acute pain due to stress or injury. The Technique helps with all joint-related pain-back, neck, arm, wrist, and leg pain that can limit your movement and mobility.. The Technique is often used by performers to help with tension, injury or performance anxiety issues; however, Alexander Technique Lessons are for anyone.. Learn how to release pain through exploration of the activities where ...
Find and compare Podiatrists in Alexander City, Alabama. Alexander City podiatrists with photos, bios, and list of foot conditions treated. Browse the directory of Alexander City Podiatrists.
Dr. Scott F. Alexander is dedicated exclusively to holistically treating hair loss in both men and women. He performs all microscopically prepared follicular unit grafting using the lateral slit technique for placement. He performs all his free consultations personally to help his patients evaluate all their treatment options. His techniques and equipment are state of the art. Dr. Alexander is the founder and medical director of Biltmore Surgical Hair Restoration located in Phoenix Arizona. He is a fourth generation Arizona native who grew up in Phoenix. He attended Brigham Young University where he received his Bachelor of Science degree with a minor in art and design. Dr. Alexanders residency training was in general surgery at Mount Sinai Medical Center in Cleveland Ohio. He has always been very interested in art with great ability in that area. Being very meticulous with a drive for perfection, he has sought out the best techniques and mastered them. Dr. Scott Alexander uses all the latest, ...
I want to thank you for working with DEA and the state of Tennessee to approve Tennessees application, which will allow our state to begin its pilot program this year. … This is a very important issue for Tennessees agricultural department, and I appreciate you being responsive to our requests.-Lamar Alexander. WASHINGTON, May 7, 2015 - U.S. Sen. Lamar Alexander (R-Tenn.) today praised the Drug Enforcement Administrations (DEA) decision to approvethe state of Tennessees application to import certified industrial hemp seeds for research purposes. Alexander thanked Attorney General Loretta Lynch for working with DEA and the state of Tennessee to approve Tennessees registration and import permit application.. I want to thank you for working with DEA and the state of Tennessee to approve Tennessees application, which will allow our state to begin its pilot program this year, Alexander told Lynch at a subcommittee hearing yesterday. This is a very important issue for Tennessees ...
A fascinating discussion with psychologist, Dr. Bruce Alexander, professor emeritus from Simon Fraser University, Vancouver, who explains the global addiction epidemic, sociologically, as the end product of modernity and capitalism. He describes the addiction epidemic as almost, dare I say it, peak addiction. Capitalist Modernity, as a system, now globalized, strips people of a shared spirituality, culture and community that protects and nurtures people, while it isolates, dislocates and exhausts the human psyche, leaving addiction to drugs and consumption as a last resort. Alexander calls for a model of Recovery that goes beyond personal, individual recovery to a social recovery of communities and cultures that support and nurture people in a society-wide context. Dr. Alexander belongs to a group that is involved in what he calls social recovery. ...
What we have seen as the most salient weakness of William of Auxerres angelology emerges as the most noteworthy strength of the angelology of Alexander of Hales. His focus on the metaphysical status of angels is what gives his teaching its special character. In addition, that teaching makes it clear that, by the time Alexander had written his Glossa on the Sentences of Peter Lombard (1220-25), Aristotelian metaphysics has settled in for the duration and was informing the thought of scholastic theologicans not hitherto regarded as hospitable to this new philosophy. . . . Given their nature as purely spiritual beings, he asks, how can angels be understood as created substances? How can such beings be distinguished from the deity? And how can they have location? In answering these questions, Alexander shows his awareness of the fact that the term substantia is defined differently by different schools of philosophy. At the same time, the definition that clearly sets the terms of the debate, for ...
A series of 24 lessons in the Alexander technique taught by registered teachers provides long term benefits for patients with chronic or recurrent low back pain. Both six lessons in the Alexander technique and general practitioner prescription for aerobic exercise with structured behavioural counselling by a practice nurse were helpful in the long term; classic massage provided short term benefit. Six lessons in the Alexander technique followed by exercise prescription was almost as effective as 24 lessons.. Most patients we contacted were not eligible. The majority of the eligible patients who responded to an invitation to participate in the trial were randomised so the results should apply to most patients with chronic or recurrent back pain. The long previous duration of pain (79% had pain for ,90 days) and the little change in pain and function in the control group after one year (still had significant limitation in activity and pain on most days after one year) suggest that we selected a ...
A series of 24 lessons in the Alexander technique taught by registered teachers provides long term benefits for patients with chronic or recurrent low back pain. Both six lessons in the Alexander technique and general practitioner prescription for aerobic exercise with structured behavioural counselling by a practice nurse were helpful in the long term; classic massage provided short term benefit. Six lessons in the Alexander technique followed by exercise prescription was almost as effective as 24 lessons.. Most patients we contacted were not eligible. The majority of the eligible patients who responded to an invitation to participate in the trial were randomised so the results should apply to most patients with chronic or recurrent back pain. The long previous duration of pain (79% had pain for ,90 days) and the little change in pain and function in the control group after one year (still had significant limitation in activity and pain on most days after one year) suggest that we selected a ...
From: [email protected] (Glenn Campbell, Las Vegas) Date: Wed, 12 Feb 1997 22:11:34 -0800 Subject: Picnic with the Penguin (John Alexander) [IUFO] [From IUFO Mailing List, via [email protected]] From: Blue Resonant Human ,[email protected]> SearchNets IUFO Mailing List ::: Picnic with the Penguin ::: Beep beep beep - beep beep beep - beep beep beep beep...... May I speak with John Alexander please? we asked. This is John Alexander, the reply. And so began our Monday afternoon adventure with the mad scientist of NIDS (http://www.accessnv.com/nids/), LANLs now-infamous Penguin. Figuring him for a cold-blooded bird, we set our phasers a notch or two past stun, raised our shields and prepared a photon torpedo just in case. All of this proved unnecessary, however, as we were soon to discover not a wicked governmental sociopath of Frankensteinian proportion but rather a soft-spoken older gentleman who didnt mind spending a bit of time on the phone with this curious individual. We hadnt ...
By Guy MacLean Rogers. For almost and a part millennia, Alexander the good has loomed over heritage as a legend-and an enigma. Wounded again and again yet continuously effective in conflict, he conquered many of the identified global, simply to die mysteriously on the age of thirty-two. In his day he was once respected as a god; in our day he has been reviled as a mass assassin, a tyrant as brutal as Stalin or Hitler. Who used to be the fellow in the back of the masks of strength? Why did Alexander embark on an extraordinary application of worldwide domination? What accounted for his incredible luck at the battlefield? during this luminous new biography, the esteemed classical student and historian man MacLean Rogers sifts via hundreds of thousands of years of historical past and fable to discover the reality approximately this complicated, ambiguous genius.. Ascending to the throne of Macedonia after the assassination of his father, King Philip II, Alexander came upon whereas slightly out of ...
Fagan P, Pokhrel P, Herzog TA, Moolchan ET, Cassel KD, Franke AA, Li X, Pagano I, Trinidad DR, Sakuma KK, Sterling K, Jorgensen D, Lynch T, Kawamoto C, Guy MC, Lagua I, Hanes S, Alexander LA, Clanton MS, Graham-Tutt C, Eissenberg T; Addictive Carcinogens Workgroup..Sugar and adelyde content in electronic liquid cigarettes. Nicotine Tob Res. 2018 Jul 9;20(8):985-992. doi: 10.1093/ntr/ntx234. PubMed PMID: 29182761; PubMed Central PMCID: PMC6037055. Alexander LA, Senior Volume Editor, Author, Chapters (1-3) A Socioecological Approach to Addressing Tobacco-Related Health Disparities. U.S. National Cancer Institute National Cancer Institute Tobacco Control Monograph 22. NIH Publication No. 17-CA-8035A. Bethesda, MD: U.S. Department of Health and Human Services, National Institutes of Health, National Cancer Institute; 2017. This monograph and its supplemental materials found electronically at http://cancercontrol.cancer.gov/brp/tcrb/monographs/22/index.html. Alexander, L.A., Trinidad, D.R., Sakuma, ...
The Alexander technique is an educational self-development self-management method with therapeutic benefits. The primary focus of the technique is learning about the self, conceptualized as a mind-body unity. Skills in the technique are gained experientially, including through hands-on and spoken guidance from a certified Alexander teacher, often using everyday movement such as walking and standing. In this article the authors summarize key evidence for the effectiveness of learning the Alexander technique and describe how the method was developed. They attempt to convey a sense of the unique all-encompassing and fundamental nature of the technique by exploring the perspectives of those engaged in teaching and learning it and conclude by bringing together elements of this account with relevant strands of qualitative research to view this lived experience in a broader context. ...
Dr. Matthew Alexander obtained his PhD in Genetics and Development from the University of Texas Southwestern Medical Center at Dallas in the lab of Dr. Daniel Garry where he studied the roles of forkhead transcription factors in the regulation of muscle stem cells. In 2008 he joined the laboratory of Dr. Louis Kunkel (Harvard Medical School and Boston Childrens Hospital) as a postdoctoral fellow where his work focused on the roles of epigenetic and genetic modifiers of human neuromuscular diseases with an emphasis on Duchenne muscular dystrophy (DMD), myotonic dystrophy (DM), and Limb-girdle muscular dystrophy (LGMD). In 2013, Dr. Alexander was promoted to an Instructor in Pediatrics and Genetics and Genomics and was appointed as an affiliate of the Stem Cell Program at Boston Childrens Hospital. In 2016, Dr. Alexander moved his laboratory to the Childrens of Alabama/University of Alabama at Birmingham (UAB) where he is an Assistant Professor in Pediatric Neurology and Genetics. He currently ...
Intracranial calcification may occur physiologically or pathologically and may be observed in asymptomatic individuals. Clinical assessment and laboratory investigations are required to determine whether these changes are physiological, idiopathic, neoplastic, inflammatory, traumatic, caused by metabolic disease, or manifestations of a generalised disease, such as hyperparathyroidism, vitamin D toxicity, Aicardi-Goutières syndrome, cerebroretinal microangiopathy with calcifications, COL4A1-related disease, Degos disease, Krabbe disease, Alexander disease, mitochondrial disease, tetrasomy 15, Hutchinson-Gilford progeria syndrome or chronic renal failure [1-3].. Certain intracranial tumours, especially oligodendrogliomas and craniopharyngiomas, tend to undergo calcification. Tumour calcifications were observed in approximately 83% of craniopharyngiomas [4] and 40% of intracranial oligodendrogliomas [5]. Approximately 22 to 62% of benign meningiomas were reported to contain calcification, while ...
Actor and recording artist Alexander James Rodriguez is releasing his latest song Holiday in L.A on November 6 on all digital platforms in support of UNICEF USA, the worlds largest childrens humanitarian organization working to provide children with safe, clean drinking water, health care, education, emergency relief and more.*. Video Message: https://www.youtube.com/watch?v=AHKank4m_bg. The thirteen-year-old, who was first introduced to the original Band of Merrymakers song during his 5th grade Holiday Show performance, has launched a fundraiser on the charitys GoFundMe, to raise vital funds for children worldwide. The upbeat and exciting charity Christmas song was recorded in North Hollywood, where the tween corralled his closest friends to sing on the chorus and backing vocals.. Alexanders charity song Holiday in L.A will release November 6 on all digital streaming platforms including Apple Music, Spotify, Amazon Music, YouTube Music, Pandora, Tidal and DEEZER.. To learn more visit: ...
Alexander Maidment1 has no recorded parents. He was born about 1870 at Warwick, Lambton, ON, CA. 1 He worked as a Farmer in 1892 at Warwick, Lambton, ON, CA. 1 He worked as a Laborer in 1897 at Forest, Lambton, ON, CA. 2 He worked as a Laborer in 1905 at Sarnia, ON, CA. 3 He worked as a Laborer in 1901 at Point Edward, Lambton, ON, CA. 4 He died on 14 February 1905 Pneumonia, 2 weeks at 204 Parker St, Sarnia, ON, CA. 5,3 The cause of death was Pneumonia, 2 weeks3 . He was buried at Beechwood Cemetery, Forest, Lambton, ON, CA. 5 He married Sarah Catherine Sitter. He married Sarah Catherine Sitter on 25 June 1892 at Warwick, Lambton, ON, CA. 1 Sarah Catherine Sitter6,5 was the daughter of David Sitter and Hannah Muma. She was born about 1873 at Warwick, Lambton, ON, CA. 6,7 She lived in 1906 at Forest, Lambton, ON, CA. 6 She died private . 5 She was buried at Beechwood Cemetery, Forest, Lambton, ON, CA. Children of Alexander Maidment and Sarah Catherine Sitter: ...
Aaronson, Scott (2004) Is Quantum Mechanics An Island in Theoryspace? [Preprint] Aaronson, Scott (2011) Why Philosophers Should Care About Computational Complexity. [Preprint] Afriat, Alexander (2002) Altering the remote past. [Preprint] Afriat, Alexander (2004) Duhem, Quine and the other dogma. [Preprint] Afriat, Alexander (2008) Duhem, Quine and the other dogma. [Preprint] Afriat, Alexander (2004) If Bertlmann had three feet. [Preprint] Afriat, Alexander (2013) Is the world made of loops? [Preprint] Afriat, Alexander (2012) Logic of gauge. [Preprint] Ahmed, Arif and Caulton, Adam (2014) Causal Decision Theory and EPR correlations. [Preprint] Allori, Valia (2015) How to Make Sense of Quantum Mechanics(and More):Fundamental Physical Theories and Primitive Ontology. [Preprint] Allori, Valia (2012) On the Metaphysics of Quantum Mechanics. [Preprint] Allori, Valia (2012) Primitive Ontology and the Structure of Fundamental Physical Theories. [Preprint] Allori, Valia and Goldstein, Sheldon and ...
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Alexander, the Great :: (Alexandros). 1.Parentage and Early Life: Alexander, of Macedon, commonly called the Great (born 356 BC), was the son of Philip, king
General Keith B. Alexander Director Of The National Security Agency And Cybersecurity. When you think about NSA, here is what I think about, these are the best, most noble people in the world from my perspective. they come in everyday thinking about how they can protect this country. Keith B. Alexander Complete Full Transcript.
The chain capital of the world just keeps getting richer, doesnt it? In recent weeks, our privileged little hamlet has seen a string of chain restaurants, particularly of the swank-and-swagger variety, open their doors to diners with prosaic palates and bulging wallets. J. Alexanders, a Nashville-based chain, is one such restaurant, and along with the newly opened Ocean Prime (another upscale chain) anchors the Rialto, a 350,000-square-foot mixed-use development complex on the corner of Turkey Lake and Sand Lake roads. If youve dined at places like the Village Tavern, Houstons or Stonewood Grill, youll be familiar with what J. Alexanders has to tender a consistent offering of quality fare dished up in comfortably modern environs. In fact, the décor is a notch above the others; not only does its minimalist, polished cherrywood interior fuse nicely with the hushed lighting, it also ties into the restaurants credo of simplicity, that being a vow to serve straightforward
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1715 (1) 1881 Census (1) 1901 Census (2) 1901 Irish Census (1) 1911 (2) 1911 Census (7) 1911 Irish Census (1) 1939 Register (1) 1971 Census (1) 50-50 Club (8) A Family Life Revealed (1) Abbey St Bothans (1) Abbey St Bathans (1) Abbotsford (2) Abbotsford House (1) Abbotsford Trust (1) Aberdeen (4) Accessible Tourism (1) Acts (1) Adam Clark (3) AddressingHistory (5) Administrations (1) Admiral Collingwood (1) Admiralty Records (1) ADOnLine2 (1) Adoption (1) Advertisements (1) aerial images (1) Agatha Christie (1) AGM (1) Agnes Campbell (1) Agnes Cushny (1) Agra (1) Ahnentafel (1) Aitchison (1) Alan Brydon (1) Alastair Redpath (1) Albert Stewart Hume (1) Alexander Dow (2) Alexander Hume (1) Alexander Linton (1) Alexander Munro (1) Alexander Scott (1) Alexander Somerville (1) Algeria (1) Allanton (1) Allenby (1) Allied Military Conferences (1) Alnwick (2) Alnwick Castle (1) Amanda Beam-Frazier (1) Amberley Publishing (1) Ambulances (1) America (6) Ancestral Scotland (3) ancestry (26) AncestryHour ...
Oxygen.com interviews filmmaker and reporter Benita Alexander, an executive producer of the 90-minute documentary Seduced by Evil, about con man Derek Alldred. Alexander is well-known for her career in production and film - and was also in a relationship scam that made headlines and fueled her documentary, He Lied About Everything. Picture this: You meet your ideal partner. Hes not just attractive. He is sweet, he is kind, and he treats you to the works: rose petals, lovely dinners, deep intimacy. He wants to marry you, he says. And then, you find out everything you thought about him was a lie.. Is it a dating, or romance, or relationship scam? Or simply put, a love con? Fraud goes by many a name (and, sometimes, as it was in the case of Derek Alldred, so do the actors). That attachment, forged on lies, turns odious, and most people dont know what to do with that pain.. Do you try to hate the person who lied to you, and sever all connection, even memory? Do you retreat to the shadows to ...
Life and history of Alexander the Great. Alexander was born in Pella, the ancient capital of Macedonia in July 356 BC. One of the first major battles...
As Ive stated over and over again black and gold is my favorite color combination when it comes to fashion and Alexander McQueen has always been one of my favorite designer brands. Put them together and you have got one fabulous fashion piece. If you currently do not own a clutch, the Alexander McQueen Skull Padlock Fold-Over Clutch is a lovely one to add to your collection.. This is the type of clutch that you can literally carry whenever you want. First and foremost, black and gold is one of the most beautiful and fashionable color combination out there. I say this because you can easily downplay and up play the colors easily. The colors are beautiful enough for the daytime but they are flashy enough for the evening. The color combination is striking and really catches your eye. Second, the clutch isnt too fancy but its not exactly casual either. I could easily carry this clutch when Im in a pair of jeans and I can also carry it when Im in a cute black dress. The clutch is very ...
Reproductive Rights Interview: Alexander Sanger says firm determination to achieve equality and justice motivated his grandmother, Margaret by Joseph Ford Cotto. San Francisco Review of Books. March 13, 2017. Interview: Alexander Sanger explains how his grandmother, Margaret, challenged existing male power structures and institutions by Joseph Ford Cotto. San Francisco Review of Books. March 10, 2017. Interview:…
PHOENIX - The photographs present a chilling portrait of sex and death.. A nude Jodi Arias on Travis Alexanders bed. A naked Alexander in the shower. Then minutes later, an image of Alexander stabbed and slashed nearly 30 times in the heart, back, hands and torso, shot in the head, his throat slit from ear to ear.. Other evidence has stacked up since the June 2008 attack in Mesa, a suburb of Phoenix. A bloody palm print; wildly conflicting stories; and, finally, a confession.. The evidence - including time-stamped photos from the day police say Alexander died - is being presented at a trial in Phoenix thats been dominated by the torrid affair, sex, jealousy and a defendant whose only chance at acquittal is to convince a jury shes the victim.. Theres no question who killed the 30-year-old businessman and motivational speaker. Arias admits she stabbed and shot him, but claims she was defending herself against an abusive lover.. Alexander lunged at Jodi in anger, her attorney, Jennifer ...
Contents of the nanoworld disk N6 Correspondence Alexander Soroka (cont-d) Georgiy Ivanov (cont-d) Anthony Martin (cont-d) Vladimir Zubov (cont-d) Dmitry Sazonov Immo Alexander Chepik (cont-d) Stas Kuznetsov (cont-d) Vladimir Potapov Dmitry Kozhevnikov (cont-d) Oleg Safonov (cont-d) Mikhail Vladimir Nikolaevich (DPR-72) Peter Vladimir Vladimir Andrey Yan Mathieu Olga Dore (cont-d) Energy saving - 2003 newphysics Zlata transfer lider Esteban Forum2 Nikolay Chavarga Alexander Vikoruk Timur Abdulov Oleg Bondarenko Vazeikin Alla Gudz Andrey Basov Nikolai Ryabets A.A. Shabronov Konstantin (cont-d) Diamond instruments Lesha (prints V.A. Padins manuscript) Vitaly Dugin Vasily Padin Svyazinvest Vyacheslav Likhota Podoba A.V. Frolov Alexey Shershnev Evgeny Lepeshev Alexander Alexander Tratsevsky Prudnikov Y.M. Bubnov Vladimir Savukov Islam Asiful Andrey Pogoreltsev Zinovy Doctorovich Vladimir Korovin Yuri Ivanov Sergey Polischyuk (cont-d) Sergey Ivlev Kanat Valery Morozov Vladimir Kotenko (cont-d) ...
Original Articles:. Rosenthal NE, Rosenthal LN, Stallone F, Fleiss J, Dunner DL, Fieve RR: Psychosis as a predictor of response to lithium maintenance treatment in bipolar affective disorder. Journal of Affective Disorders, 1: 237-245, 1979.. Rosenthal NE, Yudofsky S : ECT in a depressed patient with adult onset diabetes mellitus. American Journal of Psychiatry, 137: 100-101, 1980.. Rosenthal NE, Davenport Y, Cowdry RW, Webster MH, Goodwin FK: Monoamine metabolites in cerebrospinal fluid of depressive subgroups. Psychiatry Research, 2: 113-119, 1980.. Rosenthal NE, Rosenthal LN, Stallone F, Dunner DL, Fieve RR: Toward the validation of RDC schizoaffective disorder. Archives of General Psychiatry, 37: 804-810, 1980.. Rosenthal NE, Lewy AJ, Wehr TA, Goodwin FK, Newsome DA : Manic-depressive patients may be supersensitive to light. Lancet, 383-384, Feb 14, 1981.. Rosenthal NE, Wilson LG, Dunner DL: The phenomenology of bipolar I manic-depressive illness. Canadian Journal of Psychiatry, 27(2): ...
Eric S. Rosenthal, MD, serves as Medical Director of the Neurosciences Intensive Care Unit at Massachusetts General Hospital.. Dr. Rosenthal is board certified in neurology, neurocritical care, and epilepsy. He sees patients in the MGH Neurosciences ICU, and as part of the MGH Neurology Divisions of Clinical Neurophysiology and Neurocritical Care. His clinical interests include traumatic brain injury (TBI), subarachnoid hemorrhage (SAH), acute stroke, intracerebral hemorrhage, and seizure disorders in critically ill patients, including status epilepticus and seizure-spectrum patterns Academically, Dr. Rosenthal is principal investigator of the MGH ICU Precision Medicine Lab, whose mission is to develop treatments to prevent secondary neuronal injury after acute brain injury by characterizing physiologic biomarkers of poor outcome. He performs this work as ICU Director of the MGH Clinical Data Animation Center and as faculty within the Center for Neurotechnology and NeuroRecovery, focusing on ...
This book is the most useful summary of present knowledge about epidemiology, pathophysiology, assessment and management of spinal cord injuries today. It is a great book that deserves a widespread distribution among spine surgeons and physicians involved in the treatment of spinal injuries. - European Journal of Orthopaedic Surgery & Traumatology Neurotrauma and Critical Care of the Spine, 2nd edition, by a distinguished critical care neurosurgeon, Jack Jallo, and a renowned spine surgeon, Alexander Vaccaro, incorporates salient components of the highly praised first edition. The updated text reflects cutting-edge discussion on spine injury management in a neurocritical care setting. Contributions from top experts in neurosurgery, orthopaedic surgery, neurology, critical care, cardiac and pulmonary care, and trauma surgery infuse this book with a well-rounded perspective. From the pre-hospital to intensive care setting, this unique reference provides a comprehensive, yet concise approach to ...
Detailed profile of Mariam Priya Alexander, MD, a Pathologist - Anatomic Pathology & Clinical Pathology, Pathologist - Clinical Pathology/Laboratory Medicine Rochester MN. See insurances she accepts. Read ratings and reviews from other patients.
Barreto, George E.; Iarkov, Alexander; Moran, Valentina Echeverria (January 2015). "Beneficial effects of nicotine, cotinine ... Illustration of Parkinson's disease by William Richard Gowers, first published in A Manual of Diseases of the Nervous System ( ... 2006). "Diagnosing Parkinson's Disease". Parkinson's Disease. London: Royal College of Physicians. pp. 29-47. ISBN 978-1-86016- ... Parkinson's Disease at Curlie. *Parkinson's Disease: Hope Through Research (National Institute of Neurological Disorders and ...
Granderath, Frank Alexander; Kamolz, Thomas; Pointner, Rudolph (2006). Gastroesophageal Reflux Disease: Principles of Disease, ... Gastroesophageal reflux disease. Other names. British: Gastro-oesophageal reflux disease (GORD);[1] gastric reflux disease, ... "Testing for refractory gastroesophageal reflux disease" (PDF). Retrieved 20 August 2018.. *^ a b c d e Using the Proton Pump ... October 2004). "There is no difference in the disease severity of gastro-oesophageal reflux disease between patients infected ...
Robyn Alexander. "Addison's Disease or Hypoadrenocorticism". Scwtca.org. Retrieved 15 April 2017.. ... Other Wheaten health issues are renal dysplasia, inflammatory bowel disease, Addison's disease,[15] and cancer. Some Wheatens ... Robyn Alexander. "Soft Coated Wheaten Terrier Club of America - Wheaten Health". Swctca.org. Retrieved 11 December 2017.. ... Robyn Alexander. "History of the Breed − Soft Coated Wheaten Terrier Club of America". Scwtca.org. Retrieved 11 December 2017. ...
GeneReviews/NCBI/NIH/UW entry on Alexander disease OMIM entries on Alexander disease Glial Fibrillary Acidic Protein at the US ... "Alexander Disease". Medical College of Wisconsin. Hagemann TL, Connor JX, Messing A (October 2006). "Alexander disease- ... Chen YS, Lim SC, Chen MH, Quinlan RA, Perng MD (October 2011). "Alexander disease causing mutations in the C-terminal domain of ... GFAP therefore plays an important role in the pathogenesis of Alexander disease. Notably, the expression of some GFAP isoforms ...
Alexander van Geen, et al. "Impact of population and latrines on fecal contamination of ponds in rural Bangladesh." Science Of ... Acute disease. An acute disease is a short-lived disease, like the common cold.. Chronic disease. A chronic disease is one that ... hereditary diseases (including both genetic diseases and non-genetic hereditary diseases), and physiological diseases. Diseases ... Subclinical disease. Also called silent disease, silent stage, or asymptomatic disease. This is a stage in some diseases before ...
Alexander van Geen, et al. "Impact of population and latrines on fecal contamination of ponds in rural Bangladesh." Science Of ... Acute disease. An acute disease is a short-lived disease, like the common cold.. Chronic disease. A chronic disease is one that ... It also sounds like it could imply secondary disease, but acquired disease can be primary disease.. Acute disease disease of a ... hereditary diseases (including both genetic diseases and non-genetic hereditary diseases), and physiological diseases. Diseases ...
CYP11B1 Alexander disease; 203450; GFAP Alexander disease; 203450; NDUFV1 Alkaptonuria; 203500; HGD Allan-Herndon-Dudley ... RNF212 Refsum disease; 266500; PEX7 Refsum disease; 266500; PHYH Refsum disease, infantile form; 266510; PEX26 Refsum disease, ... PSEN1 Alzheimer disease-10; 104300; AD10 Alzheimer disease-2; 104310; APOE Alzheimer disease-4; 606889; PSEN2 Alzheimer disease ... RLBP1 Niemann-Pick disease, type A; 257200; SMPD1 Niemann-Pick disease, type B; 607616; SMPD1 Niemann-Pick disease, type C1; ...
Sanders, DA; Kobinger, GP (19 February 2015). "Transmission of Ebola viruses: what we know and what we do not know". mBio. 6 (2 ... Ebola virus disease at Curlie. *CDC: Ebola hemorrhagic fever - Centers for Disease Control and Prevention, Special Pathogens ... Main articles: Ebola virus cases in the United States, Ebola virus disease in Spain, and Ebola virus disease in the United ... "Ebola virus disease - Democratic Republic of the Congo - Disease outbreak news: Update 6 June 2019". World Health Organization ...
"Occupational Health Guideline for Ozone" (PDF). Centers for Disease Control and Prevention. Alexander, D. D.; Bailey, W. H.; ... Perez, V; Alexander, DD; Bailey, WH (15 January 2013). "Air ions and mood outcomes: a review and meta-analysis". BMC Psychiatry ...
Alexander Skene. Treatise on the Diseases of Women. D. Appleton & Co, New York, 1889.. ... As pelvic inflammatory disease is the major cause of hydrosalpinx formation, steps to reduce sexually transmitted disease will ... The major cause for distal tubal occlusion is pelvic inflammatory disease (PID), usually as a consequence of an ascending ...
Quinlan RA, Brenner M, Goldman JE, Messing A (June 2007). "GFAP and its role in Alexander disease". Experimental Cell Research ... include such diseases as Creutzfeldt-Jakob disease and other prion diseases, Alzheimer's disease, Parkinson's disease, ... disease]; proteopathies pl.; proteopathic adj) refers to a class of diseases in which certain proteins become structurally ... For example, in Alzheimer's disease, researchers are seeking ways to reduce the production of the disease-associated protein Aβ ...
Alexander (2008). Poultry Diseases (6th ed.). Elsevier. pp. 317. ISBN 978-0-7020-28625. Ali A, Avalos RT, Ponimaskin E, Nayak ... "Seasonal Influenza (Flu)" Centers for Disease Control and Prevention. March 22, 2012. https://www.cdc.gov/flu/about/viruses/ ...
Pattison; McMullin; Bradbury; Alexander (2008). Poultry Diseases (6th ed.). Elsevier. pp. 317. ISBN 978-0-7020-28625. "Seasonal ... Influenza (Flu)" Centers for Disease Control and Prevention. March 22, 2012. https://www.cdc.gov/flu/about/viruses/types.htm ...
Julie Alexander, 64, British model and actress, Alzheimer's disease. Horace Hahn, 87, American actor. Peter Guy Ottewill, 87, ... Joan Franks Williams, 72, American composer, Parkinson's disease. ...
... see Alexander disease). Dame Ingrid Allen, Northern Irish neuropathologist. Friedrich August von Ammon (1799-1861), German ... Alexander A. Maximow (1874-1928), Russian-American scientist, histologist and embryologist. John McCrae (1872-1918), Canadian ... William Boog Leishman (1865-1926), English authority on the pathology of human parasitic diseases (see leishmaniasis) George ... Adolf Weil (1848-1916), German physician and pathologist (see Weil's disease). Ronald S. Weinstein (born 1938), American ...
Kapu Rajaiah, 87, Indian painter, complication of Parkinson's disease. Alexander Saxton, 93, American novelist and historian. ... Sandy Cullen; Gayle Worland. "Former U.S. District Judge Shabaz dies at 81". Wisconsin State Journal. Host.madison.com. ... Neville Alexander, 75, South African revolutionary and linguist, cancer. Aurora Bautista, 86, Spanish film actress. Malcolm ... Carl Davis, 77, American record producer ("Duke of Earl", "(Your Love Keeps Lifting Me) Higher and Higher"), lung disease. Tom ...
For voluntary service to People with Coronary Heart Disease. Alexander Gill. For services to the fishing community in Kingston- ... Alexander Crombie, Group Chief Executive, Standard Life. For services to the Insurance Industry in Scotland. Dr. Andrew Cubie, ... Professor Alan Alexander Paterson, Professor of Law, Strathclyde University. For services to Legal Education and to Law. Adam ... David Alexander James Hepworth, Q.G.M., lately Senior Investigations Adviser, British Embassy, Kabul. For services to the ...
Alexander, DJ (eds.). Poultry diseases (6th ed.). Edinburgh: Elsevier/Butterworth-Heinemann. pp. 451-452. ISBN 978-0-7020-2862- ... The parasite causes disease in the cecum, where, on post-mortem examination (necropsy), a cream-colored exudate is seen. EM, ... Eimeria meleagridis is a species of coccidia found worldwide, which causes mild disease in young turkeys aged 4-8 weeks. ... ISBN 0-8391-0066-3. Trees, AJ (2008). "Chapter 39: Parasitic diseases: Turkey coccidiosis". In Pattison, M; McMullin, PF; ...
Alexander Skvortsov, 65, Russian ice hockey player, Olympic champion (1984). Fernando Suarez, 52, Filipino Roman Catholic ... Taty Sumirah, 68, Indonesian badminton player, 1975 Uber Cup winner, lung disease. Jimmy Thunder, 54, Samoan-born New Zealand ... Wichie Torres, 67, Puerto Rican painter, cardiovascular disease. Grazia Volpi, 78, Italian film producer (Caesar Must Die, ... Henry Akin, 75, American basketball player (New York Knicks, Seattle SuperSonics, Kentucky Colonels). Duane Alexander, 79, ...
Mercer, Alexander (2014), Infections, Chronic Disease, and the Epidemiological Transition. A New Perspective, Rochester, NY: ... Such a transition can account for the replacement of infectious diseases by chronic diseases over time due to increased life ... With fewer people dying from infectious diseases, there is a rising prevalence of chronic and/or degenerative diseases in the ... The global burden of disease website provides visual comparisons of the disease burdens of countries and the changes over time ...
Alexander Skene, MD - authority on women's diseases; discovered the paraurethral glands known as Skene's ducts (1880). Robert L ... Alzheimer's Disease Research Program Brooklyn Center for Health Disparities Center for Biomedical Imaging Center for ... and Alzheimer's disease; Adult/pediatric emergency services: the ER receives more than 68,906 patient visits a year [2010 data ...
Katz, Jay; Capron, Alexander Morgan (1975). Catastrophic Diseases: Who Decides What?, p. 35-36 Simmons, John G. (2002). Doctors ... It is a life support treatment and does not treat disease. On 12 December 1957, Kolff implanted an artificial heart into a dog ... Sandy; Nunnally, Sara (2011). Barbarians of Wealth: Protecting Yourself from Today's Financial Attilas, p. 57-58 Rolland, Gail ...
Alexander Jon Stoessl is a Canadian neurologist and Parkinson's disease researcher. He is the director of the Pacific ... In 2001, Stoessl published a paper in Science which found that the placebo effect in Parkinson's disease might be due to ... Stoessl, Alexander Jon; Bushnell, Mary Catherine; Schulzer, Michael; Mak, Edwin; Troiano, Andre R.; Nandhagopal, R. (2010). " ... "Response to Heat Pain Stimulation in Idiopathic Parkinson's Disease". Pain Medicine. 11 (6): 834-840. doi:10.1111/j.1526- ...
Donna Mitchell as Sandy MacKenna, Vincent's wife who has Alzheimer's disease. Kimberly Quinn as Ana, a nurse at Sandy's nursing ... After staff in Sandy's nursing home have told him he is behind on fees and Sandy will be moved, Vincent steals money from ... His wife, Sandy, developed Alzheimer's years ago and can no longer recognize him, but he poses as a doctor to visit her and ... Vincent is confronted in his home by loan sharks Zucko and Antwan who attempt to take Sandy's jewelry. Vincent suddenly falls ...
Its presence is associated with either pilocytic astrocytoma (more common) or Alexander's disease (a rare leukodystrophy). They ... July 1, 2016). "Composition of Rosenthal Fibers, the Protein Aggregate Hallmark of Alexander Disease". Journal of proteome ...
The couple handles the disease for several years until Sandy dies. Following her death, Sandy's parents (Anne Meara and Al ... Brooke Shields as Janine Nielssen Cherry Jones as Sandy Cataldi Anne Meara as Evelyn Cataldi Al Waxman as Frank Cataldi Whoopi ... After the birth of their daughter Heather, Sandy is diagnosed with systemic lupus when she collapses at the baby's christening ... Janine Nielsen (Brooke Shields) and her partner, Sandy Cataldi (Cherry Jones), elect to conceive a baby via artificial ...
"Alexander Fleming Award Winners". Infectious Diseases Society of America. Retrieved 15 May 2018. CS1 maint: discouraged ... He was awarded the Alexander Fleming Award for Lifetime Achievement from the Infectious Diseases Society of America in 2007. " ... He was editor-in-chief of the journal Clinical Infectious Diseases from 2000 to 2016. He graduated from Brandeis University in ... CS1 maint: discouraged parameter (link) "Physician honored for pioneering work in infectious disease". Tufts Journal. Retrieved ...
Alexander, D.J (2000). "Newcastle disease and other avian paramyxoviruses" (PDF). Revue Scientifique et Technique ( ... Avian metaavulavirus 2 has reservoirs in feral avian species and is known to cause respiratory disease and have economic ... The most common serotype of Avulavirinae is serotype 1, the cause of Newcastle disease (ND).[citation needed] Avian ... "Requirements for the Assembly and Release of Newcastle Disease Virus-Like Particles". Journal of Virology. 80 (22): 11062-11073 ...
McKie, Robin; Rice, Xan (April 22, 2007). "Millions face famine as crop disease rages". Guardian. London.. ... As underweight children are more vulnerable to almost all infectious diseases, the indirect disease burden of malnutrition is ... Overeating leads to many diseases, such as heart disease and diabetes, that may result in death. ... This conditions may include Crohn's disease or untreated coeliac disease.[4][9][52] Malnutrition may also occur due to ...
"Alexander Street.. Vassar College. Archives and Special Collections Library. *Benedict, Ruth. 1931. Tales of the Cochiti ... Fulton loved his work and research, it eventually led to his premature death, as he acquired an unknown disease during one of ... She enjoyed the class and took another anthropology course with Alexander Goldenweiser, a student of noted anthropologist Franz ...
Diseases of the endocrine system (ICD-10 Chapter IV: Endocrine, nutritional and metabolic diseases - Endocrine diseases, E00- ... Kyu HH, Bachman VF, Alexander LT, Mumford JE, Afshin A, Estep K, Veerman JL, Delwiche K, Iannarone ML, Moyer ML, Cercy K, Vos T ... Diabetes was one of the first diseases described.[21] The importance of insulin in the disease was determined in the 1920s.[22] ... two to four times the risk of cardiovascular disease, including ischemic heart disease and stroke; a 20-fold increase in lower ...
Disease-related deaths in California. *Metro-Goldwyn-Mayer contract players. *20th-century American actresses ... Sandy Dennis (1966). *Estelle Parsons (1967). *Ruth Gordon (1968). *Goldie Hawn (1969) ...
... while imbalance results in disease. Such disease-inducing imbalances can be adjusted and balanced using traditional herbs, ... In Britain, the most often used alternative therapies were Alexander technique, Aromatherapy, Bach and other flower remedies, ... A belief that a substance that causes the symptoms of a disease in healthy people cures similar symptoms in sick people.[n 8] ... Treatments for severe diseases such as cancer and HIV infection have well-known, significant side-effects. Even low-risk ...
Hinton, Alexander Laban (2005). Why Did They Kill: Cambodia in the Shadow of Genocide. University of California Press. ISBN 978 ... there he was diagnosed with Hodgkin's disease.[376] In mid-1984, Office 131 was moved to a new base further into Cambodia, near ...
"Alexander's Ragtime Band" / "Gambling Polka Dot Blues" Vocalion 04275 "Tulsa Stomp" / "Little Red Head" Vocalion 04235 ... Infectious disease deaths in Texas. *Songwriters from Texas. *Songwriters from Oklahoma. *Singers from Oklahoma ...
Disorders, pests and diseasesEdit. The most important disorders affecting cauliflower quality are a hollow stem, stunted head ... and moist soil conditions high in organic matter and sandy soils.[1] The earliest maturity possible for cauliflower is 7 to 12 ...
... through the End Stage Renal Disease Program) people of all ages with end-stage renal disease. The Medicare Program provides a ... In most cases, [Sandy Praeger, Insurance Commissioner of Kansas] said, adults with incomes from 32 percent to 100 percent of ... chronic obstructive pulmonary disease; and complications of devices, implants and grafts.[78] ...
... a charity dedicated to research into the prevention and treatment of blindness and eye disease,[39] and was a member of the ... Prince Alexander John of Wales. *Alfred, Hereditary Prince of Saxe-Coburg and Gotha ...
Graft-versus-host disease[edit]. Main article: Graft-versus-host disease. Graft-versus-host disease (GVHD) is an inflammatory ... Alexander, Tobias; Arnold, Renate; Hiepe, Falk; Radbruch, Andreas (2016-07-01). "Resetting the immune system with ... Veno-occlusive disease[edit]. Severe liver injury can result from hepatic veno-occlusive disease (VOD). Elevated levels of ... Major complications are veno-occlusive disease, mucositis, infections (sepsis), graft-versus-host disease and the development ...
Coccidians in the genus Aggregata living in the gut cause severe disease to the host. Octopuses have an innate immune system, ... used for example by Alexander of Tralles (c. 525-c. 605) for the common octopus.[3][4][5][6] The standard pluralised form of " ... The diseases and parasites that affect octopuses have been little studied, but cephalopods are known to be the intermediate or ...
The results of this research was used as a model for Kashin-Beck disease. Kashin-Beck is a result of combinatorial ... Alexander Friedenstein and his colleagues first identified osteoprogenitor cells in multiple mammalian tissues, before any ... The disease has symptoms similar to those resulting from Trsp gene knockout.[12] ... a putative model for Kashin-Beck disease". PLOS Genet. 5 (8): e1000616. doi:10.1371/journal.pgen.1000616. PMC 2721633. PMID ...
listen)) is the science and practice of the diagnosis, treatment, and prevention of disease.[4][5] The word "medicine" is ... Voluntas aegroti suprema lex.). *beneficence - a practitioner should act in the best interest of the patient. (Salus aegroti ... Preventive medicine is the branch of medicine concerned with preventing disease. *Community health or public health is an ... Pathology as a medical specialty is the branch of medicine that deals with the study of diseases and the morphologic, ...
Alexander, L.; Grierson, D (October 2002). "Ethylene biosynthesis and action in tomato: a model for climacteric fruit ripening" ... Korean scientists are looking at using the tomato to express a vaccine against Alzheimer's disease.[42] Hilary Koprowski, who ... Redenbalpolollolneau, Matthew Kramer, Ray Sheehy, Rick Sanders, Cathy Houck and Don Emlay (1992). Safety Assessment of ... "Transgenic tomatoes expressing human beta-amyloid for use as a vaccine against Alzheimer's disease". Biotechnology letters. 30 ...
Nikiforova MN, Lynch RA, Biddinger PW, Alexander EK, Dorn GW, Tallini G, Kroll TG, Nikiforov YE (May 2003). "RAS point ... differentiation and disease". Nature Reviews. Endocrinology. 11 (1): 29-42. doi:10.1038/nrendo.2014.186. PMID 25350068.. ... "Pax genes in renal development, disease and regeneration". Seminars in Cell & Developmental Biology. Paramutation & Pax ...
Hume, Beth; Sanders, Stephanie. "Enrollment Report 2019" (PDF). The Ohio State University Office of Student Academic Success. ... a research institute for cardiovascular disease. ...
Manuel Bandeira, Brazilian poet, had TB in 1904 and expressed the effects of the disease in his life in many of his poems. ... Alexander Stephens. *Sudirman, Commander of Indonesia's armed forces during its National Revolution ... He was rumored to have discovered his disease when he coughed blood and fainted during the Ikedaya Affair. ... and ultimately died of the disease days after a New York City recording session. ...
November 13 - Alexander Grothendieck, 86, German-born French mathematician, winner of the Fields Medal (1966).[49] ... November 6 - Rick Rosas, 65, American session musician (Etta James, Joe Walsh, Crosby, Stills, Nash & Young), lung disease.[23] ... November 16 - Carl Sanders, 89, American politician, Governor of Georgia (1963-1967), complications from a fall.[68] ... November 3 - Tinus Linee, 45, South African rugby player, motor neurone disease.[11] ...
DNR Fishing Regulation Changes Reflect Disease Management Concerns with VHS Archived 2008-12-14 at the Wayback Machine ... Newall, Charles F. "The problem of pain in nature." Publisher: Paisley : Alexander Gardner (1917). May be downloaded from: ... In 2007, several American states, enacted regulations designed to slow the spread of fish diseases, including viral hemorrhagic ... Alexander Schwab; Cory Suski; Stephen G. Sutton; Eva B. Thorstad ... whirling disease), trout and salmon should not be used as bait ...
The town was incorporated on June 21, 1793,[3] and named for Alexander Hamilton, whose portrait became the town seal in 1903. ... By the early 17th century their numbers were reduced to several hundred by European diseases. Masconomet befriended the white ...
Disease has to be very virulent to kill off all the individuals in a genus or species, and even such a virulent disease as West ... Miller, Gifford; Magee, John; Smith, Mike; Spooner, Nigel; Baynes, Alexander; Lehman, Scott; Fogel, Marilyn; Johnston, Harvey; ... DiseaseEdit. The hyperdisease hypothesis, proposed by Ross MacPhee in 1997, states that the megafaunal die-off was due to an ... DiseaseEdit. See also: Decline in amphibian populations, White nose syndrome, Colony collapse disorder, and Pesticide toxicity ...
Diseases[edit]. Below is a list of the most common lentil diseases. ... Lentils can grow on various soil types, from sand to clay loam, growing best in deep sandy loam soils with moderate fertility. ... The wild species possess many diverse traits including disease resistances and abiotic stress tolerances. The above-mentioned L ... progress in quantity and quality as well as in the resistance to disease and abiotic stresses are the major breeding aims.[1] ...
"Eur-lex Europa". 2005. Retrieved 15 June 2014.. *^ "Directive 2007/47/ec of the European parliament and of the council". Eur- ... Intended for use in the diagnosis of disease or other conditions, or in the cure, mitigation, treatment, or prevention of ... Pycroft, Laurie; Boccard, Sandra G.; Owen, Sarah L.F.; Stein, John F.; Fitzgerald, James J.; Green, Alexander L.; Aziz, Tipu Z ... lex Europa. 5 September 2007. Retrieved 15 June 2014.. *^ "Revision of the medical device directives". European Commission. ...
Hockenbury, Don and Sandy (2004). Discovering Psychology. Worth Publishers. ISBN 0-7167-5704-4.. ... Robert Anda of the U.S. Centers for Disease Control describes the relation between childhood adversity and mental health (video ...
... disease had become the most common cause of death.[205] Disease-related mortality then continued to take its toll through early ... The sandy soil of the east and the lighter sedimentary soil of the Sundarbans tended to drain more rapidly after the monsoon ... and provided a more hospitable environment for water-borne diseases such as cholera and malaria. Such diseases clustered around ... Famine, disease, and the death tollEdit. Conditions drifted towards famine at different rates in different Bengal districts. ...
Niigata Minamata disease. *Poisoning of Alexander Litvinenko. *Seveso disaster. *Consumption of Tide Pods ... Zaderko, Alexander N.; Shvets, Roman Ya.; Grygorchak, Ivan I.; Afonin, Sergii; Diyuk, Vitaliy E.; Mariychuk, Ruslan T.; ...
"There is not enough evidence satisfactorily to identify the disease or diseases", concluded J. F. Gilliam in his summary (1961 ... Lucian, Alexander, 36. *^ Niebuhr, Lectures on the history of Rome III, Lecture CXXXI (London 1849), quoted by Gilliam 1961:225 ... As the disease swept north to the Rhine, it also infected Germanic and Gallic peoples outside the empire's borders. For years, ... Rats, Lice and History: A Chronicle of Disease, Plagues, and Pestilence (1935). Reprinted by Black Dog & Leventhal Publishers, ...
The Armenian population was either forced on long death marches to camps in the middle of the Syrian desert to die of disease, ... The head of the Armenian Church, along with the president of the Armenian National Council of Tiflis, Alexander Khatisyan, ... Assuming the same trend held true in the Caucasus, Ottoman disease deaths would number ~ 170,000, and total deaths would number ... A total of 235,733 permanent casualties (83,083 killed, 113,570 critically wounded, 39,080 prisoners). Disease deaths ...
Mass, Alla; Supin, Alexander (21 May 2007). "Adaptive features of aquatic mammals' eyes". Anatomical Record. 290 (6): 701-715. ... These pollutants can cause gastrointestinal cancers and greater vulnerability to infectious diseases.[102] They can also be ...
Paterson, Sue (December 17, 2007). Skin Diseases of Exotic Pets. Blackwell Science, Ltd. pp. 74-79. ISBN 9780470752432. .. ... Farmer, CG; Sanders, K (2010). "Unidirectional airflow in the lungs of alligators". Science. 327 (5963): 338-340. Bibcode: ... Hellebuyck, Tom; Pasmans, Frank; Haesbrouck, Freddy; Martel, An (July 2012). "Dermatological Diseases in Lizards". The ... a common skin disease in snakes and lizards, will occur when ecdysis, or shedding, fails.[94] There are numerous reasons why ...
Alexander disease is a rare disorder of the nervous system. Explore symptoms, inheritance, genetics of this condition. ... medlineplus.gov/genetics/condition/alexander-disease/ Alexander disease. ... Zang L, Wang J, Jiang Y, Gu Q, Gao Z, Yang Y, Xiao J, Wu Y. Follow-up study of 22 Chinese children with Alexander disease and ... Alexander disease is a rare disorder of the nervous system. It is one of a group of disorders, called leukodystrophies, that ...
Alexander disease is a very rare disorder of the nervous system. Heres what causes it and how it can affect different age ... What is Alexander disease?. Alexander disease is a very rare disorder of the nervous system. Normally, nerve fibers are covered ... Alexander disease in older adults (65+). Its extremely rare for Alexander disease to develop this late in life. If it does, ... What causes this disease?. Alexander disease is caused by a defect in the glial fibrillary acidic protein (GFAP) gene in around ...
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OMIM entries on Alexander disease Infantile-onset Alexander disease in a child with long-term follow-up by serial magnetic ... It is even possible to detect adult-onset Alexander disease with MRI. Alexander disease may also be revealed by genetic testing ... alexander_disease at NINDS "Cause of brain disease found" -BBC News "Archived copy". Archived from the original on 2010-04-28. ... Alexander disease belongs to leukodystrophies, a group of diseases that affect the growth or development of the myelin sheath. ...
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Sendes innen 5‑9 virkedager.. Kjøp boken Disease Dynamics av Alexander Asachenkov (ISBN 9780817636920) hos Adlibris.com. Fri ... This text discusses mathematical modelling, analysis and control of the immune system and disease dynamics. The purpose of the ... to provide a tutorial systematic description of how the immune system controls diseases and to present several significant ...
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Walker, Alexander R. P & Wadee, Ahmed A. (‎2002)‎. Preventing cardiovascular disease : a despondent view : letter / Alexander R ... Preventing cardiovascular disease : a despondent view : letter / Alexander R. P. Walker and Ahmed A. Wadee. ...
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Can MR Imaging Diagnose Adult-Onset Alexander Disease?. L. Farina, D. Pareyson, L. Minati, I. Ceccherini, L. Chiapparini, S. ... Can MR Imaging Diagnose Adult-Onset Alexander Disease?. L. Farina, D. Pareyson, L. Minati, I. Ceccherini, L. Chiapparini, S. ... Can MR Imaging Diagnose Adult-Onset Alexander Disease?. L. Farina, D. Pareyson, L. Minati, I. Ceccherini, L. Chiapparini, S. ... Alexander disease. Ventricular garlands and abnormalities of the medulla and spinal cord. Neurology 2006;66:494-98. ...
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Borrett D, Becker LE (1985) Alexanders disease. A disease of astrocytes. Brain 108 (Part 2):367-385.PubMedGoogle Scholar ... Messing A, Goldman JE (2004) Alexander disease. In: Lazzarini RA, ed), Myelin and its diseases (Elsevier Academic Press. San ... Seil FJ, Schochet SS Jr, Earle KM (1968) Alexanders disease in an adult. Report of a case. Arch Neurol 19:494-502.PubMedGoogle ... Quinlan RA, Brenner M, Goldman JE, Messing A (2007) GFAP and its role in Alexander disease. Exp Cell Res 313:2077-2087.PubMed ...
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A Study to Evaluate the Safety and Efficacy of ION373 in Patients With Alexander Disease (AxD) ... Not sure for Clinical phenotype and brain imaging consistent with a diagnosis of Alexander disease inclusion criteria 1 ... Yes for Clinical phenotype and brain imaging consistent with a diagnosis of Alexander disease inclusion criteria 1 ... No for Clinical phenotype and brain imaging consistent with a diagnosis of Alexander disease inclusion criteria 1 ...
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  • They officially shared the news with concerned family and friends via a dedicated Facebook page, "Moving with Meris - Our Journey with Alexander Disease" on Dec. 31, 2017. (knoxnews.com)
  • Mutations in the GFAP gene cause Alexander disease. (medlineplus.gov)
  • Quinlan RA, Brenner M, Goldman JE, Messing A. GFAP and its role in Alexander disease. (medlineplus.gov)
  • Alexander disease is caused by a defect in the glial fibrillary acidic protein (GFAP) gene in around 90 percent of cases, according to the Genetic and Rare Diseases Information Center. (healthline.com)
  • The GFAP gene is involved in the development of cell structure, but more research is needed to understand GFAP's specific role within health and disease. (healthline.com)
  • The cause of Alexander disease is a mutation in the gene encoding GFAP. (wikipedia.org)
  • The great majority of all cases of Alexander Disease (infantile, juvenile and adult) are caused by a defect in a specific gene called GFAP, which stands for Glial Fibrillary Acidic Protein. (ulf.org)
  • Defects in GFAP have been found to be the major cause of Alexander Disease (see What causes Alexander Disease, above). (ulf.org)
  • In recent years, the discovery that mutations in the glial fibrillary acidic protein gene ( GFAP ) were responsible for Alexander disease (AD) brought recognition of adult cases. (ajnr.org)
  • 4 After 2001, the discovery that mutations in the glial fibrillary acidic protein gene ( GFAP ) were responsible for the disease 5 , 6 allowed recognition during life of juvenile or adult forms 1 , 7 - 20 that have an MR imaging pattern remarkably different from that observed in children, with predominant focal involvement of the lower brain stem. (ajnr.org)
  • Dynamics of mutated GFAP aggregates revealed by real-time imaging of an astrocyte model of Alexander disease. (nih.gov)
  • Alexander disease (AxD) is a rare neurodegenerative disorder characterized by large cytoplasmic aggregates in astrocytes and myelin abnormalities and caused by dominant mutations in the gene encoding glial fibrillary acidic protein (GFAP), the main intermediate filament protein in astrocytes. (nih.gov)
  • Mutated GFAP-GFP expressed in astrocytes formed networks or aggregates similar to those found in the brains of patients with the disease. (nih.gov)
  • Asahina N, Okamoto T, Sudo A, Kanazawa N, Tsujino S, Saitoh S (2006) An infantile-juvenile form of Alexander disease caused by a R79H mutation in GFAP. (springer.com)
  • The classic hallmark of all forms of Alexander disease is the presence of Rosenthal fibers, abnormal inclusions in astrocytes that contain the intermediate filament protein GFAP. (drugster.info)
  • Mutations in the gene for GFAP (glial fibrillary acidic protein) cause Alexander disease, the first known example of a primary genetic disorder of astrocytes, one of the major cell types in the vertebrate CNS. (drugster.info)
  • These fibers mainly contain GFAP and are a result of mutation within GFAP coding gene, which is specific for the Alexander disease. (animalabs.com)
  • Leukodystrophy Labrador retriever type or Alexander disease is caused by a mutation in the GFAP gene. (animalabs.com)
  • Alexander disease is a rare and typically fatal neurodegenerative disease that results from heterozygous mutations in the gene encoding the type III intermediate filament protein GFAP. (grantome.com)
  • Prior investigations by our groups have let to the acceptance of GFAP mutations as the cause for nearly all cases of Alexander disease, and the rapid translation of this information to clinical practice as the standard for diagnosis. (grantome.com)
  • However, the mechanisms by which GFAP mutations cause astrocyte dysfunction and disease remain unclear. (grantome.com)
  • PROJECT 1 Principal Investigator: Michael Brenner Title: Biochemistry and Genetics of Alexander Disease Description (provided by applicant): Glial fibrillary acidic protein (GFAP) is a structural protein found almost exclusively in astrocytes. (grantome.com)
  • Our laboratory recently found that mutations in the coding region of the GFAP gene cause Alexander disease (AxD), a rare but usually fatal disorder of the central nervous system. (grantome.com)
  • This disease is characterized by the presence of protein aggregates which have GFAP as a primary constituent. (grantome.com)
  • This will test the hypothesis that mutant GFAP is not toxic per se, but produces disease by causing GFAP accumulation. (grantome.com)
  • Alexander disease is a rare, progressive, and generally fatal neurological disorder that results from dominant mutations affecting the coding region of GFAP , the gene encoding glial fibrillary acidic protein, the major intermediate filament protein of astrocytes in the central nervous system. (eneuro.org)
  • We find that GFAP levels are consistently elevated in the CSF of Alexander disease patients, but only occasionally and modestly in blood. (eneuro.org)
  • These results provide the foundation for future studies that will explore whether GFAP levels can serve as a convenient means to monitor progression of disease and response to treatment. (eneuro.org)
  • Here we show that the fluid levels of GFAP increase markedly in Alexander disease, a genetic disorder that results from mutations in GFAP itself, particularly in the CSF. (eneuro.org)
  • The cause of Alexander's disease, a very rare, inherited CNS disorder, has been traced to the gene for glial fibrillary acidic protein (GFAP), according to a report published in this month's Nature Genetics. (alzforum.org)
  • Adult-onset Alexander disease, associated with a mutation in an alternative GFAP transcript, may be phenotypically modulated by a non-neutral HDAC6 variant. (cam.ac.uk)
  • [1] [2] Alexander disease is caused by mutations in the GFAP gene . (cdc.gov)
  • Alexander disease is an hereditary leukodystrophy related to mutations of GFAP. (cdc.gov)
  • Now 2½, Meris White is adjusting to her new normal after months of testing revealed last November that she has Alexander Disease (AxD), a form of Leukodystrophy. (knoxnews.com)
  • Qwynn and husband Brandon are adjusting to Meris' new normal after months of testing revealed last November that their little girl has Alexander Disease (AxD), a form of Leukodystrophy. (knoxnews.com)
  • Alexander disease is a very rare autosomal dominant leukodystrophy, which are neurological conditions caused by anomalies in the myelin which protects nerve fibers in the brain. (wikipedia.org)
  • These results suggested that Alexander disease astrocytes contribute to leukodystrophy and a variety of symptoms as an inflammatory source in the Alexander disease patient brain. (biomedcentral.com)
  • Alexander disease is a leukodystrophy, a group of more than 15 rare genetic disorders that cause progressive degeneration of the white matter of the brain due to imperfect growth or destruction of the myelin sheath, the fatty covering that insulates nerve fibers in the brain and spinal cord and promotes rapid transmission of nerve impulses. (nationalstemcellfoundation.org)
  • The most common leukodystrophies include Canavan disease, Krabbe disease, metachromatic Leukodystrophy (MLD), Childhood Ataxia with Central Nervous System Hypomyelination (CACH), Alexander disease and Refsum disease. (nationalstemcellfoundation.org)
  • Alexander disease is a type of leukodystrophy characterized by the destruction of the myelin sheath (the fatty covering that acts as an insulator around nerve fiber) and abnormal protein deposits known as Rosenthal fibers. (cdc.gov)
  • Alexander disease is a rare, progressive, leukodystrophy that usually becomes apparent during infancy or early childhood but juvenile and adult onset forms have also been reported. (rarediseases.org)
  • Mutations in TREM2 predispose patients to Alzheimer's disease, Parkinson's disease, and ALS, indicating that these molecules are closely associated with a central pathway linked to neurodegeneration (review in MM-Painter et al. (weizmann.ac.il)
  • Bar H, Mucke N, Kostareva A, Sjoberg G, Aebi U, Herrmann H (2005) Severe muscle disease-causing desmin mutations interfere with in vitro filament assembly at distinct stages. (springer.com)
  • Research is aimed at understanding the mechanisms of the mutations that cause the disease and to screen FDA approved drugs for beneficial effects and to counter effect the symptoms of the disease. (newyorkessays.com)
  • Researchers from the University of Missouri and the 99 Lives Cat Genome Sequencing Initiative today announced groundbreaking discoveries of novel mutations in the cat genome found to correlate to two human eye diseases, retinitis pigmentosa and Leber's Congenital Amaurosis. (sandyrobinsonline.com)
  • Alexander disease is also characterized by abnormal protein deposits known as Rosenthal fibers. (medlineplus.gov)
  • The Rosenthal fibers found in Alexander disease do not share the distribution or concentration of other diseases and disorders. (wikipedia.org)
  • In Alexander Disease, a specific type of glial cell known as an astrocyte has abnormal structures known as Rosenthal fibers. (ulf.org)
  • Rosenthal fibers are found in conditions other than Alexander disease, including some cancers, although the significance of this is not clear. (ulf.org)
  • These features allowed the diagnosis without biopsy, which was performed in the search for Rosenthal fibers, the histologic hallmark of the disease. (ajnr.org)
  • Alexander disease is a fatal neurological illness characterized by white-matter degeneration and formation of Rosenthal fibers, which contain glial fibrillary acidic protein as astrocytic inclusion. (biomedcentral.com)
  • Alexander disease patient astrocytes exhibited Rosenthal fiber-like structures, a key Alexander disease pathology, and increased inflammatory cytokine release compared to healthy control. (biomedcentral.com)
  • There are many Rosenthal fibers evident (as they are in infantile Alexander Disease), but the lack of myelin is less prominent than in the infantile form. (nationalstemcellfoundation.org)
  • Symptoms can be similar to those of the juvenile form, although the course of disease may also be so mild that symptoms are not noticed and goes undiagnosed until an autopsy reveals the presence of Rosenthal fibers. (nationalstemcellfoundation.org)
  • The symptoms sometimes mimic those of Parkinson's disease or multiple sclerosis, or may present primarily as a psychiatric disorder. (wikipedia.org)
  • nd This book stems from the 2 Parkinson's Disease Symposium on "Neurotoxic Factors in Parkinsons disease and related disorders", held on August 6-7,1999 at the University ofUlm Medical School in Ulm at the Danube, Germany. (booktopia.com.au)
  • The specific topic, neurotoxic factors in Parkinson's disease (PD), was chosen in light of accumulating neurobiological and epidemiological evidence indicating that the causes of this second most common neurodegenerative disorder, and possibly of related conditions such as multiple systems atrophy, in some manner involve environ- mental (xenobiotic) and even endogenous toxic agents. (booktopia.com.au)
  • Following on from previous workshops and activities, The Walter Carrington Educational Trust (WCET) is subsidising places for ten STAT-registered teachers to participate in two workshops supporting teaching the Alexander Technique to pupils with Parkinson's Disease. (constructiveteachingcentre.com)
  • After studying Chloe Stallibrass ' research on Alexander Technique and Parkinson's and participating in a workshop with The Poise Project , she became passionate about the potential benefits of the Alexander Technique to the quality of life of people living with Parkinson's. (constructiveteachingcentre.com)
  • The only therapy recommended by the National Institute for Health and Clinical Evidence (NICE) is the Alexander Technique to help day-to-day movement for people with Parkinson's. (alexandertechniqueinessex.co.uk)
  • Parkinson's Disease is a progressive neurological condition. (alexandertechniqueinessex.co.uk)
  • Research trials, including a Randomised Controlled Trial, were carried out in 1997, 2002 and 2005 on the effectiveness of the Alexander Technique in helping those with Parkinson's. (alexandertechniqueinessex.co.uk)
  • An evaluation of the Alexander Technique for the management of disability in Parkinson's disease - a preliminary study. (alexandertechniqueinessex.co.uk)
  • Randomized controlled trial of the Alexander Technique for idiopathic Parkinson's disease. (alexandertechniqueinessex.co.uk)
  • Retention of skills learnt in Alexander Technique lessons: 28 people with idiopathic Parkinson's disease. (alexandertechniqueinessex.co.uk)
  • I have been using Alexander Technique for several years, originally for low back pain, but more recently (for over 3 years ) for the symptoms of Parkinson's Disease. (alexandertechniqueinessex.co.uk)
  • I can confirm that it (Alexander Technique) is a real help in easing the symptoms of muscular tension, distorted posture and shuffling gait of Parkinson's disease and also improves the characteristic low mood. (alexandertechniqueinessex.co.uk)
  • 12 months after my diagnosis of Parkinson's Disease, I decided to try the Alexander Technique (AT) because I had a problem with standing , walking and moving generally. (alexandertechniqueinessex.co.uk)
  • The drug selegiline, thought to be neuroprotective, has been used to treat Parkinson's disease for the past 25 years, but a report a few years ago suggested that the drug could accelerate death in patients taking it. (alzforum.org)
  • He has specialised in Parkinson's Disease (PD) and other Movement Disorders for the last 40 years, with a particular interest in young onset Parkinson's disease(YOPD), multiple system atrophy (MSA), progressive supranuclear palsy (PSP) and neural transplantation. (sen.es)
  • He is on the Editorial Boards of: Journal of Parkinson's Disease, and Parkinsonism & Related Disorders, & previously of Movement Disorders, JNNP, Lancet Neurology and Movement Disorders Clinical Practice. (sen.es)
  • Graff-Radford J, Schwartz K, Gavrilova RH, Lachance DH, Kumar N. Neuroimaging and clinical features in type II (late-onset) Alexander disease. (medlineplus.gov)
  • In general, the earlier the onset of the disease, the more severe the symptoms and the more quickly the condition progresses. (healthline.com)
  • The juvenile form of Alexander disease has an onset between the ages of 2 and 13 years. (wikipedia.org)
  • Adult-onset forms of Alexander disease are less common. (wikipedia.org)
  • It is even possible to detect adult-onset Alexander disease with MRI. (wikipedia.org)
  • Alexander Disease has been divided into three forms based on age of onset and type of symptoms: infantile, juvenile, and adult forms. (ulf.org)
  • All of the forms are rare, although adult onset Alexander disease is the most rare of the group. (ulf.org)
  • Symptoms vary between the three forms of the disease (infantile, juvenile, and adult-onset), so we have separated them into categories below. (ulf.org)
  • Can MR Imaging Diagnose Adult-Onset Alexander Disease? (ajnr.org)
  • The detection of early-onset Alzheimer's disease can result in more effective treatment. (internal-medicine-centers.com)
  • Everybody at any age can be afflicted by heart disease and by getting screened through methods such as checking your blood pressure, cholesterol levels, EKG, diabetes, etc. allows you the opportunity to catch the onset of heart disease conditions early and take appropriate actions to mitigate, alleviate, or prevent it from happening. (alexandershope.org)
  • Adult-onset Alexander Disease is the rarest form of the disease, and is also also generally the most mild. (nationalstemcellfoundation.org)
  • Alexander disease can be divided into three types (infantile, juvenile and adult), dependent on the age of onset and the clinical signs. (animalabs.com)
  • Alexander disease in Labrador retrievers can be compared with the juvenile type of the disorder in man, based on symptoms and age of their onset. (animalabs.com)
  • Three independent studies published in the 22 December issue of Science reported that chromosome 10 probably harbors one or more genes that confer an increased susceptibility to late-onset Alzheimer's disease. (alzforum.org)
  • Unusual presentations and intrafamilial phenotypic variability in infantile onset Alexander disease. (cdc.gov)
  • Those affected by MLD typically appear healthy until onset, or when an individual experience symptoms of the disease. (huntershope.org)
  • As myelin deteriorates in leukodystrophies such as Alexander disease, nervous system functions are impaired. (medlineplus.gov)
  • Gorospe JR, Maletkovic J. Alexander disease and megalencephalic leukoencephalopathy with subcortical cysts: leukodystrophies arising from astrocyte dysfunction. (medlineplus.gov)
  • Alexander disease belongs to leukodystrophies, a group of diseases that affect the growth or development of the myelin sheath. (wikipedia.org)
  • Alexander disease is classified as one of the leukodystrophies, the diseases of the white matter of the brain. (drugster.info)
  • The leukodystrophies are often referred to as "demyelinating" diseases. (nationalstemcellfoundation.org)
  • In clinical practice, distinguishing 'classical' inherited leukodystrophies from other causes of white matter disease, including vascular and inflammatory disorders, may not always be straightforward. (bmj.com)
  • Leukodystrophies are a group of rare, progressive, metabolic, genetic diseases that affect the brain, spinal cord and often the peripheral nerves. (rarediseases.org)
  • Leukodystrophies are progressive diseases meaning that the symptoms of the disease tend to get worse over time. (rarediseases.org)
  • Magnetic resonance imaging (MRI) has markedly increased the awareness of hereditary white matter diseases associated with the formation of myelin and hypomyelination, in addition to the previously described classic leukodystrophies. (rarediseases.org)
  • If your child has received a diagnosis of Alexander disease, there are organizations that can provide support. (healthline.com)
  • The diagnosis of rheumatoid meningoencephalitis was made on the basis of brain biopsy findings and serological evidence of active rheumatoid disease. (bmj.com)
  • Here at Eye 1st Vision Center, our optometry team takes diagnosis and treatment of eye diseases very seriously. (eye1stvision.com)
  • If you show signs of eye disease, we'll provide you with an accurate diagnosis of your condition so you can get treatment. (eye1stvision.com)
  • Diagnosis of Alexander Disease has not been added yet. (rareshare.org)
  • Describe an algorithmic approach to the differential diagnosis of a patient with white matter disease. (slideshare.net)
  • Becker LE, Teixeira F (1988) Alexander's disease. (springer.com)
  • IMSEAR at SEARO: Alexander's disease: report of a case presenting as obstructive hydrocephalus. (who.int)
  • Chandar K, Basden EH, Anderson MS. Alexander's disease: report of a case presenting as obstructive hydrocephalus. (who.int)
  • It is not well understood how impaired astroglial cells contribute to the abnormal formation or maintenance of myelin, leading to the signs and symptoms of Alexander disease. (medlineplus.gov)
  • In Alexander disease, myelin is destroyed. (healthline.com)
  • Demyelination (loss of myelin, the insulation around nerves) is also a prominent feature of the disease. (drugster.info)
  • Alexander disease is characterized by degenerative changes of the white matter of the brain caused by a lack of normal amounts of myelin. (rarediseases.org)
  • Rarely, a neonatal form of Alexander disease occurs within the first month of life and is associated with severe intellectual disability and developmental delay, a buildup of fluid in the brain (hydrocephalus), and seizures. (medlineplus.gov)
  • The disease occurs in both males and females, and no ethnic, racial, geographic or cultural/economic differences are seen in its distribution. (wikipedia.org)
  • Usually, the later the disease occurs, the slower its course. (wikipedia.org)
  • Infantile Alexander Disease occurs in different ethnic groups and areas of the world, and does not appear to be prevalent in any particular group. (ulf.org)
  • While this disease occurs on a great variety of hosts, it is of most consequence on the apple. (chestofbooks.com)
  • Alexander disease (ALX) is a rare and often fatal nervous system disorder that primarily occurs in infants and children. (drugster.info)
  • If we have a better understanding of how the disease occurs and which molecular processes are involved, we will be able to treat it much more accurately with medication in the future,' explains Becker. (fau.eu)
  • Disease, Alexander - A slowly progressive and ultimately fatal brain disorder that most commonly occurs in children. (academic.ru)
  • Degenerative Disc Disease (DDD) occurs in many people during the normal aging process, and is often referred to as 'arthritis of the back. (lunaalexanderorthopaedicsurgery.com)
  • Early disseminated disease occurs weeks to several months after the initial infection from the tick bite. (alexandercchestermd.com)
  • Late Lyme disease occurs months to years after the tick bite and, as in the case with early disseminated Lyme disease, the history of a rash or tick bite might not be present or a history of having had the earlier stages of Lyme disease. (alexandercchestermd.com)
  • A decrease in color perception also occurs in Stargardt disease. (sandycamper.com)
  • Alec Baldwin has opened about about his struggle with Lyme disease. (dailymail.co.uk)
  • Truth is, it's not easy being a Baldwin , which I'm not, but I believe I've gained a good understanding as to why Alec has gotten so damn fat. (blogspot.com)
  • Alec Baldwin latest celebrity to battle Lyme disease: What is it? (lymehandbook.com)
  • Baldwin said he has struggled with chronic Lyme disease for 17 years after he was bitten by a deer tick, treated, and then bitten again a few years later. (lymehandbook.com)
  • Two-year-old's parents with neurological disease similar to former Powell coach's children, Mabry Kate and Owen. (knoxnews.com)
  • Brandon and Qwynn White learn their daughter Meris has a neurological disease. (knoxnews.com)
  • Science says that this neurological disease is regressive and eventually detrimental. (knoxnews.com)
  • More importantly, they share the capacity to generate any cell types in the body, a property that is particularly useful for the study of neurological diseases. (biomedcentral.com)
  • Late Lyme disease is associated with arthritis, usually involving one or a few large joints, particularly the knee, and/or neurological problems. (alexandercchestermd.com)
  • The symptoms of Alexander disease can vary. (healthline.com)
  • these familial cases may be more prevalent in the adult form of Alexander Disease than in the infantile or juvenile form (see descriptions of these under Symptoms of Alexander Disease) . (ulf.org)
  • What are the symptoms of Alexander Disease? (ulf.org)
  • The symptoms of Alexander disease vary depending on the form of the condition (neonatal, infantile, juvenile, and adult). (cdc.gov)
  • Here we describe the first discovered instance of a primary astrogliopathy , in which a defect in astrocytes indeed results in a human disorder - Alexander disease. (springer.com)
  • Alexander WS (1949) Progressive fibrinoid degeneration of fibrillary astrocytes associated with mental retardation in a hydrocephalic infant. (springer.com)
  • We established induced pluripotent stem cells from Alexander disease patients, and differentiated induced pluripotent stem cells into astrocytes. (biomedcentral.com)
  • Astrocytes, differentiated from induced pluripotent stem cells of Alexander disease, could be a cellular model for future translational medicine. (biomedcentral.com)
  • These studies promise novel insights into the role of glial filaments in the cell biology of astrocytes, and the role of astrocytes in brain function and disease. (grantome.com)
  • Welcome to the UK-ADC, one of the 10 original Alzheimer's Disease Centers funded by the National Institutes of Health. (uky.edu)
  • Our principal mission is to serve as the focal point for all Alzheimer's disease-related activities at the University of Kentucky and the Commonwealth of Kentucky, by providing an environment and core resources that catalyze innovative research, outreach, education, and clinical programs. (uky.edu)
  • Alzheimer's disease is the most common type of dementia characterized by progressive deterioration of your cognitive and memory functions which, in particular, affect your thinking capacity, memory, and behavior. (internal-medicine-centers.com)
  • The symptoms of Alzheimer's disease worsen gradually overtime and eventually inhibit daily activities and your overall independence. (internal-medicine-centers.com)
  • If you or a loved one are experience Alzheimer's disease symptoms, treatment is available to slow the progression of the disease and preserve your quality of life. (internal-medicine-centers.com)
  • To meet with a healthcare practitioner in Alexander City who specializes in Alzheimer's disease treatment , call (334) 781-7319 or contact Alabama Functional Medicine online . (internal-medicine-centers.com)
  • Although the exact cause of Alzheimer's disease is not fully understood, most healthcare professionals believe that it is caused by a combination of genetic, lifestyle, and environmental factors. (internal-medicine-centers.com)
  • Alzheimer's disease is classified as either a major or minor neurocognitive disorder. (internal-medicine-centers.com)
  • If you have Alzheimer's disease, you may forget names and locations you have known for years. (internal-medicine-centers.com)
  • These may not be signs of Alzheimer's disease, but simple signs of aging. (internal-medicine-centers.com)
  • Complications can arise from the symptoms of Alzheimer's disease. (internal-medicine-centers.com)
  • There are various ways that your healthcare provider can test for the presence of Alzheimer's disease. (internal-medicine-centers.com)
  • MRI, CT and PET scans can be used to pinpoint precise brain abnormalities to rule out other brain disorders such as strokes, tumors, or head injuries, while also looking for signs of Alzheimer's disease such as brain shrinkage. (internal-medicine-centers.com)
  • The study led by Daniel Lee, Ph.D., associate professor, UK Department of Neuroscience , and Maj-Linda Selenica, Ph.D., assistant professor, UK Department of Molecular & Cellular Biochemistry , found that polyamines prevent the clustering of a protein known as tau, which is a hallmark in Alzheimer's disease. (uky.edu)
  • Lee says additionally they found activation of Polyamine Stress Response (PSR) in postmortem brains of those with Alzheimer's disease. (uky.edu)
  • The study suggests that Alzheimer's disease may activate the PSR which may drive protein aggregation and worsen memory performance and anxiety. (uky.edu)
  • However, the data also suggest several potential entry points of therapeutic interventions to dampen the PSR in Alzheimer's disease. (uky.edu)
  • Our studies uncovered certain mechanisms of the polyamine stress response (PSR) in Alzheimer's disease," Lee said. (uky.edu)
  • We showed how polyamines and their inactive metabolites affect hallmarks of Alzheimer's disease pathology. (uky.edu)
  • This might offer new insight for polyamine supplementation or strategies in the treatment of memory decline from normal aging versus memory decline from Alzheimer's disease. (uky.edu)
  • Lee says the work marks exciting progress in their collective efforts to find treatments for memory decline and ultimately a cure for Alzheimer's disease. (uky.edu)
  • We now understand a causal link between polyamine metabolism and Alzheimer's disease neuropathology and how the enzymes for both synthesis and degradation of polyamines impact disease progression," he said. (uky.edu)
  • The molecular and genetic mechanisms involved in the initiation and progression of Alzheimer's disease (AD) are poorly understood. (alzforum.org)
  • In some cases the symptoms mimic those of Parkinson disease or multiple sclerosis . (cdc.gov)
  • Dr. Alexander J Slotwiner is a Cardiovascular Disease (cardiology) Specialist in New York, New York. (healthcare4ppl.com)
  • Having more than 20 years of diverse experiences, especially in CARDIOVASCULAR DISEASE (CARDIOLOGY), Dr. Alexander J Slotwiner affiliates with many hospitals including Kingsbrook Jewish Medical Center, Nyu Langone Hospitals, cooperates with many other doctors and specialists in medical group New York University. (healthcare4ppl.com)
  • Dr. Alexander J Slotwiner has primarily specialised in Cardiovascular Disease (cardiology) for over 20 years. (healthcare4ppl.com)
  • Dr. Alexander Chernobelsky, MD specializes in cardiovascular disease cardiology in Atlantis, FL and has over 20 years of experience in the field of medicine. (topnpi.com)
  • With more than 20 years of experience, Dr. Alexander Chernobelsky has been identified as specializing in cardiovascular disease cardiology specialist. (topnpi.com)
  • Lexington Medical Center is committed to educating our community about cardiovascular disease, which is responsible for one out of every three deaths in South Carolina. (lexmed.com)
  • A condition called chronic periodontitis, or persistent gum disease, has been linked to cardiovascular problems by medical researchers. (benchmarkdentalsandy.net)
  • Lex children have chronic complex conditions (e.g., cardiovascular disease, congenital abnormalities), potential dependence on technology (e.g., tracheostomy, cerebral spinal fluid shunts), frequent inpatient admissions, parental administration of multiple medications, multiple specialists involved in care (Srivastava et al. (dot1linhibitor.com)
  • parents are informed of the decision and generally agreeing with the decision (Devictor and Latour, 2011).Lex children have chronic complex conditions (e.g., cardiovascular disease, congenital abnormalities), potential dependence on technology (e.g., tracheostomy, cerebral spinal fluid shunts), frequent inpatient admissions, parental administration of multiple medications, multiple specialists involved in care (Srivastava et al. (dot1linhibitor.com)
  • What is chronic disease management? (canyonsmedical.com)
  • Chronic disease management is a care plan that you and your health care providers follow to ensure you stay as healthy as possible and keep the effects of your chronic disease to a minimum. (canyonsmedical.com)
  • By combining all this information, the team creates a chronic disease management plan that optimizes your outcomes. (canyonsmedical.com)
  • In addition to the 10 patients in whom AOAD was genetically confirmed, an eleventh patient whose AOAD was not genetically confirmed who presented clinical and radiologic findings identical to those observed in the other 10 patients with AOAD was included in the present series because he also had autosomal dominant disease transmission. (ajnr.org)
  • Sandy Ford with vials of pentamidine for distribution to patients with Pneumocystis pneumonia. (cdc.gov)
  • Sandy interacted skillfully with hundreds of clinicians across the United States to provide life-saving pentamidine to severely ill patients, and she kept very careful records. (cdc.gov)
  • Two weeks later, another New York physician told Sandy about 5 male patients who had both PCP and Kaposi sarcoma. (cdc.gov)
  • Sandy learned that the sexual orientation for all these patients was homosexual. (cdc.gov)
  • Patients with the juvenile and adult forms of Alexander disease typically experience ataxia and spasticity and a more slowly progressive course. (drugster.info)
  • It has a special outpatient clinic which treats patients with chronic inflammatory bowel disease and several working groups at the Department are carrying out research into the cellular and molecular causes of the disease and new forms of treatment. (fau.eu)
  • One of the first signs of Hashimoto's disease for many patients is an enlarged thyroid , colloquially referred to as a goiter . (anti-aging-bhrt.com)
  • Persisting fatigue with or without bodily pain is usually the most troubling symptom for patients with "chronic Lyme disease. (alexandercchestermd.com)
  • Accepting new patients: Yes, Dr. Alexander Chernobelsky is accepting new patients at his office. (topnpi.com)
  • Dr Alexander Kwarteng aims to identify the bacteria that likely aggravate the condition of patients suffering from lymphoedema due to lymphatic filariasis. (edctp.org)
  • Alexander Mitchell, 20, of Provo, Utah, is one of five patients treated at the University of Utah Hospital for severe vaping-related lung injuries. (hotinfonow.com)
  • This program allows patients and researchers to connect as easily as possible to help advance treatments and cures for rare diseases. (rareshare.org)
  • However, these questions are important to patients and their families to create awareness as well as to researchers to study rare diseases. (rareshare.org)
  • For the thousands of patients with eye diseases who have received this form of acupuncture treatment, 70-83% respond to treatment, depending on the type of eye disease. (sandycamper.com)
  • Michael E. Cobble, MD, the director and family practice physician​ at Canyons Medical Center, has extensive experience in managing patients who have chronic diseases using a holistic approach for optimal results. (canyonsmedical.com)
  • Many types of chronic disease are incurable, but if patients and their health care providers manage these conditions carefully, it's very often possible to live a long and rewarding life. (canyonsmedical.com)
  • Alexander Levitzki - (born 1940) is an Israeli biochemist who is a Professor of Biochemistry at the Hebrew University of Jerusalem. (academic.ru)
  • There is pathology that is consistent with the fissure disease and chronicity usually dictates its extent. (sandyclinic.com)
  • Typical and atypical presentations of various pediatric demyelinating diseases also emphasize therapy response and those that breakthrough on treatment. (springer.com)
  • I got the classic Lyme disease (symptoms) for each successive summer, for five years, every August, like this black lung, flu-like symptoms, sweating to death in my bed,' the 59-year-old said, as reported by People Magazine. (dailymail.co.uk)
  • Alec opened up as he attended the Bay Area Lyme Foundation's LymeAid benefit just outside Palo Alto. (dailymail.co.uk)
  • The former international model has been chronicling her efforts to combat Lyme disease on social media. (dailymail.co.uk)
  • I was lying in bed saying, 'I'm going to die of Lyme disease in my bed' and 'I hope someone finds me and I'm not here for too long,' he continued. (dailymail.co.uk)
  • Lyme disease, or Lyme borreliosis, is a bacterial infection spread to humans by infected ticks. (dailymail.co.uk)
  • Those that carry the bacteria responsible for Lyme disease are found throughout the UK and in other parts of Europe and North America. (dailymail.co.uk)
  • Many people with early-stage Lyme disease develop a distinctive circular rash at the site of the tick bite, usually around 3 to 30 days after being bitten. (dailymail.co.uk)
  • More serious symptoms may develop several weeks, months or even years later if Lyme disease is left untreated or is not treated early. (dailymail.co.uk)
  • Lyme disease can also lead to heart problems such as myocarditis, where the heart muscle becomes inflamed and heart failure. (dailymail.co.uk)
  • A small minority of people go on to develop long-term symptoms similar to those of fibromyalgia or chronic fatigue syndrome, called post-infectious Lyme disease. (dailymail.co.uk)
  • I got the classic Lyme disease (symptoms) for each successive summer, for five years, every August, like this black lung, flu-like symptoms, sweating to death in my bed," the Hollywood star explained to People during an appearance at Bay Area Lyme Foundation's LymeAid benefit. (hellomagazine.com)
  • Other known sufferers of Lyme disease include Kelly Osbourne , Avril Lavigne and Bella Hadid , who said her teenage years were "taken" from her due to the disease. (hellomagazine.com)
  • While Lyme disease can often be treated effectively if it's detected early on, there's a risk that you can develop severe and long-lasting symptoms if treatment is delayed. (hellomagazine.com)
  • I find it amazing that Eugene Shaprio is being quoted as a lyme disease expert. (healingwell.com)
  • Lyme disease is usually divided into three stages: early localized disease, early disseminated disease and late Lyme disease. (alexandercchestermd.com)
  • Arthritis symptoms, particularly if only the knee is involved, can appear to be a solitary problem, with no clue that the problem is caused by Lyme disease. (alexandercchestermd.com)
  • These symptoms can be the first manifestation of Lyme disease since 20% of people with the disease do not recall any rash and approximately 25% of people with the disease do not recall a tick bite. (alexandercchestermd.com)
  • Post-Lyme disease syndrome refers to symptoms such as headache, muscle pain, joint pain and fatigue that persist, but generally resolve after six months to one year. (alexandercchestermd.com)
  • A confusing issue develops when a person who has, by all accounts, been successfully treated for Lyme disease suffers continuing health problems that do not resolve with time. (alexandercchestermd.com)
  • This situation has been termed chronic Lyme disease by some and is the subject of much dispute. (alexandercchestermd.com)
  • Briefly, certain doctors and advocacy groups maintain that, in these situations, the symptoms are caused by Lyme disease that failed to be eradicated by the standard treatments. (alexandercchestermd.com)
  • Medical authorities counter that the persisting symptoms are due to another illness that, perhaps, was triggered by Lyme disease. (alexandercchestermd.com)
  • You can imagine how frustrated a person feels who had been totally healthy, was bitten by a tick, became ill with Lyme disease, failed to improve after treatment, and is now told he has a psychological illness! (alexandercchestermd.com)
  • Personally, I think that the development of symptoms compatible with fibromyalgia or chronic fatigue syndrome after Lyme disease is further proof that these illnesses are not psychological. (alexandercchestermd.com)
  • I suspect that chronic Lyme disease is not due to the persistence of the Lyme organism, but that the Lyme organism has triggered some other illness. (alexandercchestermd.com)
  • What initially was arthritis caused by the Lyme organism is now arthritis caused by another arthritic disease, itself triggered by Lyme. (alexandercchestermd.com)
  • While the Centers for Disease and Control estimates approximately 30,000 cases of Lyme disease each year, the number is likely much higher. (lymehandbook.com)
  • Celiac.com 12/12/2018 - In a step that health officials say could provide immediate relief to the estimated eight million Indians who suffer from celiac disease, the Indian government is assessing a plan to require drugmakers to declare any gluten ingredients on medical labels. (celiac.com)
  • Celiac.com 12/11/2018 - In most people without celiac disease or other gluten sensitivities, the gut does a pretty good job of processing gluten, and helps to prevent local inflammatory and immune responses. (celiac.com)
  • Pathologically, whereas the infantile form of Alexander disease generally affects the brain, the juvenile form generally leads to changes in the brain stem, rather than the brain. (nationalstemcellfoundation.org)
  • Common problems in juvenile and adult forms of Alexander disease include speech abnormalities, swallowing difficulties, seizures, and poor coordination (ataxia). (medlineplus.gov)
  • Children with hydrocephalus caused by Alexander disease usually have increased intracranial pressure and a more rapid progression of the disease. (ulf.org)
  • A lot of effort is devoted to identifying biomarkers in blood and cerebrospinal fluid to allow monitoring severity or progression of the disease and therefore provide the much needed foundation for future clinical trials. (newyorkessays.com)
  • Bassuk AG, Joshi A, Burton BK, Larsen MB, Burrowes DM, Stack C (2003) Alexander disease with serial MRS and a new mutation in the glial fibrillary acidic protein gene. (springer.com)
  • Alexander disease is mainly caused by a gene mutation encoding glial fibrillary acidic protein, although the underlying pathomechanism remains unclear. (biomedcentral.com)
  • The male patient had a mutation, absent in his half-sister, in X-linked histone deacetylase 6, a candidate MND susceptibility gene.CONCLUSIONS: Exome-NGS is an unbiased approach that not only helps identify new disease genes, but may also contribute to elucidate phenotypic expression. (cam.ac.uk)
  • By finding that the putative causative mutation for Persian PRA is in the gene that can cause LCA in humans, researchers may be able to develop models to better understand the disease pathways associated with this rare eye disease and ultimately develop diagnostic and screening tests that will improve treatment. (sandyrobinsonline.com)
  • With the help of the Maverix Analytic Platform, our first identified mutation associated with a progressive retinal atrophy in Persian cats provides a model for the study of blinding disease in humans. (sandyrobinsonline.com)
  • Some cases of familial Alexander disease have been reported. (healthline.com)
  • In Aim 1 we will determine the composition of the RFs to obtain clues for the disease mechanism, an approach that has proved fruitful for other protein aggregate disorders. (grantome.com)
  • For more information on the following disorders, search the Rare Disease Database. (rarediseases.org)
  • Dr. Brandon Drafts of Lexington Cardiology , a Lexington Medical Center physician practice, talks about how a lifetime of bad choices can lead to heart disease in this WLTX interview you can watch below. (lexmed.com)
  • Alexander disease is a genetic disorder affecting the midbrain and cerebellum of the central nervous system. (wikipedia.org)
  • Up to a few years ago, Alexander disease (AD) was known as a rare, genetically determined leukoencephalopathy affecting infants and children, characterized by macrocephaly, seizures, spasticity, and retarded psychomotor development, and leading to death in 2 months to 7 years. (ajnr.org)
  • The infantile form of the disease is characterized by megalencephaly (an abnormally large head), seizures, spasticity and developmental retardation. (drugster.info)
  • The juvenile and adult form of the disease is less common and have mental and physical effects including speech abnormalities, swallowing difficulty, seizures, poor coordination (ataxia), dysarthria and excessive vomiting. (newyorkessays.com)
  • Juvenile Alexander Disease is characterized by difficulty with talking and swallowing and the inability to cough. (nationalstemcellfoundation.org)
  • Stargardt disease is the most common form of inherited juvenile macular degeneration. (sandycamper.com)
  • Our studies will open new venues to regulation of immune responses through controlling the lifespan of APC and to prevention of development of autoimmune diseases. (grantome.com)
  • Doctors will often suspect Alexander disease based on the presented symptoms. (healthline.com)
  • No official health bodies warn of the disease being transmitted in utero, but some doctors believe it is possible there are children infected in this way- and indeed, British billionaire John Caudwell believes his family may have contracted the condition through this route. (dailymail.co.uk)
  • Dr. Alexander Myers is similar to the following 3 Doctors near Taunton, MA. (vitals.com)
  • Dr. Alexander Chernobelsky is similar to the following 3 Doctors near Lake Worth, FL. (vitals.com)
  • Alexander Mitchell's doctors at a hospital in Payson, Utah, were confused when tests came back negative for bacterial pneumonia and many common ailments. (hotinfonow.com)
  • Mitchell's case is among the most serious doctors have seen amongst the lung disease associated with vaping, now investigated by state and federal health officials - at least 193 cases in 22 states, many involving teenagers and young adults. (hotinfonow.com)
  • Alexander Mitchell thought he had the flu when he woke up earlier this summer with severe nausea, chest pain and breathing problems, but he got worse so quickly that his parents, and then even the doctors, were amazed. (hotinfonow.com)
  • In some adult cases of the disease, there can be no symptoms present at all. (healthline.com)
  • On Friday, Illinois health officials announced the first known death from a vaping-related lung disease in an adult. (hotinfonow.com)
  • Forms of RP and related diseases include Usher syndrome, Leber's congenital amaurosis, rod-cone disease, Bardet-Biedl syndrome, and Refsum disease, among others. (sandycamper.com)
  • Unusual protein deposits in the specialized cells that support the brain and spinal cord are also found in people with Alexander disease. (healthline.com)
  • Dedicated sections on diseases affecting the brain, brainstem, spinal cord and the optic nerve feature chapters that include the diagnostic work up, therapeutic management and case outcome. (springer.com)
  • Acupuncture and Chinese herbal medicine can treat many eye diseases including Age-Related Macular Degeneration (both wet and dry), Retinitis Pigmentosa, glaucoma, Stargardt's Disease, diabetic retinopathy, and many more. (sandycamper.com)
  • Retinitis pigmentosa (RP) refers to a group of inherited diseases causing retinal degeneration. (sandycamper.com)
  • A study by several researchers at the University of Kentucky's Sanders-Brown Center on Aging (SBCoA) was recently highlighted in AlzForum . (uky.edu)
  • The purpose of the book is the practical application of mathematics to immunology and medicine in order to establish a basis for more effective treatment, to provide a tutorial systematic description of how the immune system controls diseases and to present several significant examples such as malignant tumour dynamics and control, and viral hepatitis. (adlibris.com)
  • Diseases of the dog and their treatment by Muller, Georg Alfred (1851-1923). (abaa.org)
  • Around 1 in 5 people will suffer from heartburn at least once a week and treatment of GORD costs the most out of any gastrointestinal disease in many western countries. (dralexandersimring.com)
  • Treatment of acute/subacute anal fissure disease is completely dictated by signs, symptoms and clinical findings. (sandyclinic.com)
  • Clinical and bacteriological efficacy of rifampin-streptomycin combination for two weeks followed by rifampin and clarithromycin for six weeks for treatment of Mycobacterium ulcerans disease. (edctp.org)
  • Clinical efficacy of combination of rifampin and streptomycin for treatment of Mycobacterium ulcerans disease. (edctp.org)
  • The science of adapting to cold weather could change treatment of inflammatory diseases, insomnia, and trauma. (theatlantic.com)
  • Acunova is a type of acupuncture treatment that is showing remarkable results for people with eye diseases. (sandycamper.com)
  • Sandy Camper is one the few acupuncturists in the United States trained in this method of treatment. (sandycamper.com)
  • A nagging question has been that if these roles are as critical as assumed, why have genetic diseases of astrocyte dysfunction not been identified to take their place next to those due to defects in neurons and oligodendrocytes? (springer.com)
  • Alexander disease Labrador retriever type is a rare neurodegenerative disorder characterized by astrocyte dysfunction. (animalabs.com)
  • We also carefully characterize transitions across the spectrum of cognitive impairment (normal/ preclinical AD/ MCI/ dementia), with focus on definition of early disease. (uky.edu)
  • Alexander Gordon Bearn - (born March 29, 1923) was Executive Officer of the American Philosophical Society from 1997 until his retirement in 2002. (academic.ru)
  • Could This Drug-Free Practice Help Prevent Heart Disease? (sharecare.com)
  • Heart disease refers to various types of conditions that can affect heart function. (medicinenet.com)
  • There has been a significant downwards trend regarding the number of deaths and complications regarding heart disease within the United States. (alexandershope.org)
  • While this fact does bring relief that our fight against heart disease is in our favor, this statistic means that we need to push harder to defeat heart disease and minimize the chances of heart disease causing harm to friends, family, and ourselves as the risk remains quite high. (alexandershope.org)
  • Here's a few ways you can prevent heart disease. (alexandershope.org)
  • Activities that involve aerobic exercises such as running, jogging, or walking at a brisk pace are a few examples of exercise that will help drastically reduce your risks for heart disease. (alexandershope.org)
  • Foods high in salt, sugar, processed carbohydrates, as well as trans and saturated fats have all been linked to increasing your likelihood of heart disease. (alexandershope.org)
  • Please read our article on Popular Diets and Heart Health if you're interested in finding new ways you could alter your diet and decrease the likelihood of heart disease. (alexandershope.org)
  • Lack of sleep has been attributed to a higher risk of heart disease. (alexandershope.org)
  • Setting a good sleep schedule and maintaining that schedule is the easiest way to ensure that you can reduce heart disease risk as it pertains to sleeping. (alexandershope.org)
  • These substances have been shown to increase the risk of heart disease through several factors. (alexandershope.org)
  • The best way to understand your risks of heart disease is to get screened constantly and consistently as your time, budget, and other circumstances allow. (alexandershope.org)
  • Smomking can increase our risk for heart disease by causing fatty plaque buildup in the heart that can ultimately lead to heart attacks. (lexmed.com)
  • Lexington Medical Center wants you to "Just Say Know" to heart disease. (lexmed.com)
  • It's never too early to prevent heart disease. (lexmed.com)
  • Medical research has uncovered a definitive link between heart disease and certain kinds of oral infections such as periodontal disease. (benchmarkdentalsandy.net)
  • The goals of this Program Project are to investigate molecular mechanisms and functional consequences of the stress response, to explore biochemical composition and downstream effects of inclusion body formation, and to identify and characterize genetic modifiers of disease phenotype. (grantome.com)
  • It is inherited in an autosomal dominant manner, such that the child of a parent with the disease has a 50% chance of inheriting the condition, if the parent is heterozygotic. (wikipedia.org)