Alexander Disease
Rare leukoencephalopathy with infantile-onset accumulation of Rosenthal fibers in the subpial, periventricular, and subependymal zones of the brain. Rosenthal fibers are GLIAL FIBRILLARY ACIDIC PROTEIN aggregates found in ASTROCYTES. Juvenile- and adult-onset types show progressive atrophy of the lower brainstem instead. De novo mutations in the GFAP gene are associated with the disease with propensity for paternal inheritance.
Glial Fibrillary Acidic Protein
alpha-Crystallin B Chain
One of the alpha crystallin subunits. In addition to being expressed in the lens (LENS, CRYSTALLINE), alpha-crystallin B chain has been found in a variety of tissues such as HEART; BRAIN; MUSCLE; and KIDNEY. Accumulation of the protein in the brain is associated with NEURODEGENERATIVE DISEASES such as CREUTZFELDT-JAKOB SYNDROME and ALEXANDER DISEASE.
Astrocytes
A class of large neuroglial (macroglial) cells in the central nervous system - the largest and most numerous neuroglial cells in the brain and spinal cord. Astrocytes (from "star" cells) are irregularly shaped with many long processes, including those with "end feet" which form the glial (limiting) membrane and directly and indirectly contribute to the BLOOD-BRAIN BARRIER. They regulate the extracellular ionic and chemical environment, and "reactive astrocytes" (along with MICROGLIA) respond to injury.
Brain Diseases
Age of Onset
Brain
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
Magnetic Resonance Imaging
The clinicopathological spectrum of Rosenthal fibre encephalopathy and Alexander's disease: a case report and review of the literature. (1/47)
Alexander's disease is a leucodystrophy that usually presents in early childhood, but can infrequently arise in adults. It is characterised pathologically by megalencephaly, demyelination, and the presence of numerous Rosenthal fibres. Most cases have been shown to be due to mutations in the gene encoding glial fibrillary acidic protein. In rare instances, numerous Rosenthal fibres have been found at autopsy in patients who have suffered protracted debilitating systemic illnesses, some with associated brain stem signs, and in very rare instances in patients with no apparent neurological abnormality. The term "Rosenthal fibre encephalopathy" is used to distinguish these cases from those of Alexander's disease. We report the first case of Rosenthal fibre encephalopathy in a young man with AIDS, and review the literature. (+info)Alexander-disease mutation of GFAP causes filament disorganization and decreased solubility of GFAP. (2/47)
Alexander disease is a fatal neurological illness characterized by white-matter degeneration and the formation of astrocytic cytoplasmic inclusions called Rosenthal fibers, which contain the intermediate filament glial fibrillary acidic protein (GFAP), the small heat-shock proteins HSP27 and alphaB-crystallin, and ubiquitin. Many Alexander-disease patients are heterozygous for one of a set of point mutations in the GFAP gene, all of which result in amino acid substitutions. The biological effects of the most common alteration, R239C, were tested by expressing the mutated protein in cultured cells by transient transfection. In primary rat astrocytes and Cos-7 cells, the mutant GFAP was incorporated into filament networks along with the endogenous GFAP and vimentin, respectively. In SW13Vim(-) cells, which have no endogenous cytoplasmic intermediate filaments, wild-type human GFAP frequently formed filamentous bundles, whereas the R239C GFAP formed 'diffuse' and irregular patterns. Filamentous bundles of R239C GFAP were sometimes formed in SW13Vim(-) cells when wild-type GFAP was co-transfected. Although the presence of a suitable coassembly partner (vimentin or GFAP) reduced the potential negative effects of the R239C mutation on GFAP network formation, the mutation affected the stability of GFAP in cells in a dominant fashion. Extraction of transfected SW13Vim(-) cells with Triton-X-100-containing buffers showed that the mutant GFAP was more resistant to solubilization at elevated KCl concentrations. Both wild-type and R239C GFAP assembled into 10 nm filaments with similar morphology in vitro. Thus, although the R239C mutation does not appear to affect filament formation per se, the mutation alters the normal solubility and organization of GFAP networks. (+info)Gene expression analysis in mice with elevated glial fibrillary acidic protein and Rosenthal fibers reveals a stress response followed by glial activation and neuronal dysfunction. (3/47)
Alexander disease is a fatal neurodegenerative disorder resulting from missense mutations of the intermediate filament protein, GFAP. The pathological hallmark of this disease is the formation of cytoplasmic protein aggregates within astrocytes known as Rosenthal fibers. Transgenic mice engineered to over-express wild-type human GFAP develop an encephalopathy with identical aggregates, suggesting that elevated levels of GFAP in addition to mutant protein contribute to the pathogenesis of this disorder. To study further the effects of elevated GFAP and Rosenthal fibers per se, independent of mutations, we performed gene expression analysis on olfactory bulbs of transgenic mice at two different ages to follow the progression of pathology. The expression profiles reveal a stress response that includes genes involved in glutathione metabolism, peroxide detoxification and iron homeostasis. Many of these genes are regulated by the transcription factor Nfe2l2, which is also increased in expression at 3 weeks. An immune-related response occurs with activation of cytokine and cytokine receptor genes, complement components and acute phase response genes. These transcripts are further elevated with age, with additional induction of macrophage-specific markers such as Mac1 and CD68, suggesting activation of microglia. At 4 months, decreased expression of genes for microtubule-associated proteins, vesicular trafficking proteins and neurotransmitter receptors becomes apparent. Interneuron-specific transcription factors including Dlx family members and Pax6 are downregulated as well as Gad1 and Gad2, suggesting impairment of GABAergic granule cells. Together, these data implicate an initial stress response by astrocytes, which results in the activation of microglia and compromised neuronal function. (+info)Plectin regulates the organization of glial fibrillary acidic protein in Alexander disease. (4/47)
Alexander disease (AxD) is a rare but fatal neurological disorder caused by mutations in the astrocyte-specific intermediate filament protein glial fibrillary acidic protein (GFAP). Histologically, AxD is characterized by cytoplasmic inclusion bodies called Rosenthal fibers (RFs), which contain GFAP, small heat shock proteins, and other undefined components. Here, we describe the expression of the cytoskeletal linker protein plectin in the AxD brain. RFs displayed positive immunostaining for plectin and GFAP, both of which were increased in the AxD brain. Co-localization, co-immunoprecipitation, and in vitro overlay analyses demonstrated direct interaction of plectin and GFAP. GFAP with the most common AxD mutation, R239C (RC GFAP), mainly formed abnormal aggregates in human primary astrocytes and murine plectin-deficient fibroblasts. Transient transfection of full-length plectin cDNA converted these aggregates to thin filaments, which exhibited diffuse cytoplasmic distribution. Compared to wild-type GFAP expression, RC GFAP expression lowered plectin levels in astrocytoma-derived stable transfectants and plectin-positive fibroblasts. A much higher proportion of total GFAP was found in the Triton X-insoluble fraction of plectin-deficient fibroblasts than in wild-type fibroblasts. Taken together, our results suggest that insufficient amounts of plectin, due to RC GFAP expression, promote GFAP aggregation and RF formation in AxD. (+info)Neuropathology for the neuroradiologist: Rosenthal fibers. (5/47)
Distinctive intracellular structures known as inclusions may be occasionally observed on stained tissue preparations and may further suggest a specific diagnosis. Pathologists rely on these findings much as radiologists rely on findings revealed in the gray-scale patterns of densities and intensities on images. Appreciation of these inclusions can enhance the interactions of the neuroradiologist with the neuropathologist and deepen understanding of certain conditions. This report reviews the neuropathologically observed intracellular inclusions known as Rosenthal fibers in the context of Alexander disease and slow-growing tumors such as pilocytic astrocytoma. (+info)The Alexander disease-causing glial fibrillary acidic protein mutant, R416W, accumulates into Rosenthal fibers by a pathway that involves filament aggregation and the association of alpha B-crystallin and HSP27. (6/47)
Here, we describe the early events in the disease pathogenesis of Alexander disease. This is a rare and usually fatal neurodegenerative disorder whose pathological hallmark is the abundance of protein aggregates in astrocytes. These aggregates, termed "Rosenthal fibers," contain the protein chaperones alpha B-crystallin and HSP27 as well as glial fibrillary acidic protein (GFAP), an intermediate filament (IF) protein found almost exclusively in astrocytes. Heterozygous, missense GFAP mutations that usually arise spontaneously during spermatogenesis have recently been found in the majority of patients with Alexander disease. In this study, we show that one of the more frequently observed mutations, R416W, significantly perturbs in vitro filament assembly. The filamentous structures formed resemble assembly intermediates but aggregate more strongly. Consistent with the heterozygosity of the mutation, this effect is dominant over wild-type GFAP in coassembly experiments. Transient transfection studies demonstrate that R416W GFAP induces the formation of GFAP-containing cytoplasmic aggregates in a wide range of different cell types, including astrocytes. The aggregates have several important features in common with Rosenthal fibers, including the association of alpha B-crystallin and HSP27. This association occurs simultaneously with the formation of protein aggregates containing R416W GFAP and is also specific, since HSP70 does not partition with them. Monoclonal antibodies specific for R416W GFAP reveal, for the first time for any IF-based disease, the presence of the mutant protein in the characteristic histopathological feature of the disease, namely Rosenthal fibers. Collectively, these data confirm that the effects of the R416W GFAP are dominant, changing the assembly process in a way that encourages aberrant filament-filament interactions that then lead to protein aggregation and chaperone sequestration as early events in Alexander disease. (+info)Synergistic effects of the SAPK/JNK and the proteasome pathway on glial fibrillary acidic protein (GFAP) accumulation in Alexander disease. (7/47)
Protein aggregates in astrocytes that contain glial fibrillary acidic protein (GFAP), small heat shock proteins, and ubiquitinated proteins are termed Rosenthal fibers and characterize Alexander disease, a leukodystrophy caused by heterozygous mutations in GFAP. The mechanisms responsible for the massive accumulation of GFAP in Alexander disease remain unclear. In this study, we show that overexpression of both wild type and R239C mutant human GFAP led to cytoplasmic inclusions. GFAP accumulation also led to a decrease of proteasome activity and an activation of the MLK2-JNK pathway. In turn, the expression of activated mixed lineage kinases (MLKs) induced JNK activation and increased GFAP accumulation, whereas blocking the JNK pathway decreased GFAP accumulation. Activated MLK also inhibited proteasome function. A direct inhibition of proteasome function pharmacologically further activated JNK. Our data suggest a synergistic interplay between the proteasome and the SAPK/JNK pathway in the context of GFAP accumulation. Feedback interactions among GFAP accumulation, SAPK/JNK activation, and proteasomal hypofunction cooperate to produce further protein accumulation and cellular stress responses. (+info)A case of infantile Alexander disease accompanied by infantile spasms diagnosed by DNA analysis. (8/47)
Alexander disease (AD) is a rare leukodystrophy of the central nervous system of unknown etiology. AD is characterized by progressive failure of central myelination and the accumulation of Rosenthal fibers in astrocytes, and is inevitably lethal in nature. Symptomatically, AD is associated with leukoencephalopathy with macrocephaly, seizures, and psychomotor retardation in infants, and usually leads to death within the first decade. Its characteristic magnetic resonance imaging (MRI) findings have been described as demyelination predominantly in the frontal lobe. Moreover, dominant mutations in the GFAP gene, coding for glial fibrillary acidic protein (GFAP), a principal astrocytic intermediate filament protein, have been shown to lead to AD. The disease can now be detected by genetic diagnosis. We report the Korean case of an 8-month-old male patient with AD. He was clinically characterized due to the presence of psychomotor retardation, megalencephaly, spasticity, and recurrent seizures including infantile spasms which is a remarkable presentation. Demyelination in the frontal lobe and in a portion of the temporal lobe was demonstrated by brain MRI. Moreover, DNA analysis of peripheral blood showed the presence of a R239L mutation in the GFAP gene, involving the replacement of guanine with thymine. (+info)
Alexander Disease, symptoms and Alexander Disease treatments
Adult-onset Alexander disease, associated with a mutation in an alternative GFAP transcript, may be phenotypically modulated by...
Infantile-onset Alexander disease in a child with long-term follow-up by serial magnetic resonance imaging: a case report |...
Alexander disease - Wikipedia
Alexander Disease - National Stem Cell Foundation
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Alexander disease
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Alexander disease
Wikimedia Commons has media related to Alexander disease. OMIM entries on Alexander disease Infantile-onset Alexander disease ... alexander_disease at NINDS "Cause of brain disease found". January 2, 2001 - via news.bbc.co.uk. "Alexander Disease - United ... It is even possible to detect adult-onset Alexander disease with MRI. Alexander disease may also be revealed by genetic testing ... Alexander disease belongs to leukodystrophies, a group of diseases that affect the growth or development of the myelin sheath. ...
List of OMIM disorder codes
CYP11B1 Alexander disease; 203450; GFAP Alexander disease; 203450; NDUFV1 Alkaptonuria; 203500; HGD Allan-Herndon-Dudley ... RNF212 Refsum disease; 266500; PEX7 Refsum disease; 266500; PHYH Refsum disease, infantile form; 266510; PEX26 Refsum disease, ... PSEN1 Alzheimer disease-10; 104300; AD10 Alzheimer disease-2; 104310; APOE Alzheimer disease-4; 606889; PSEN2 Alzheimer disease ... RLBP1 Niemann-Pick disease, type A; 257200; SMPD1 Niemann-Pick disease, type B; 607616; SMPD1 Niemann-Pick disease, type C1; ...
Soft-coated Wheaten Terrier
Robyn Alexander. "Addison's Disease or Hypoadrenocorticism". Scwtca.org. Retrieved 15 April 2017. "SCWTDB.org , Soft Coated ... Other Wheaten health issues are renal dysplasia, inflammatory bowel disease, Addison's disease, and cancer. Some Wheatens can ... Robyn Alexander. "History of the Breed − Soft Coated Wheaten Terrier Club of America". Scwtca.org. Retrieved 11 December 2017. ... Robyn Alexander. "Soft Coated Wheaten Terrier Club of America - Wheaten Health". Swctca.org. Retrieved 11 December 2017. ...
Air ioniser
"Occupational Health Guideline for Ozone" (PDF). Centers for Disease Control and Prevention. Alexander, D. D.; Bailey, W. H.; ... In 1918 Alexander Chizhevsky had created the first air ioniser for ion therapy. It was originally used for animal health in ... Perez, V; Alexander, DD; Bailey, WH (15 January 2013). "Air ions and mood outcomes: a review and meta-analysis". BMC Psychiatry ...
Proteinopathy
Quinlan RA, Brenner M, Goldman JE, Messing A (June 2007). "GFAP and its role in Alexander disease". Experimental Cell Research ... The proteinopathies include such diseases as Creutzfeldt-Jakob disease and other prion diseases, Alzheimer's disease, ... Amyloidosis Prion-Related Diseases Protein Misfolding Diseases Book (CS1: long volume value, Articles with short description, ... For example, in Alzheimer's disease, researchers are seeking ways to reduce the production of the disease-associated protein Aβ ...
Influenza D virus
Alexander (2008). Poultry Diseases (6th ed.). Elsevier. pp. 317. ISBN 978-0-7020-28625. Ali A, Avalos RT, Ponimaskin E, Nayak ... "Types of Influenza Viruses". Influenza (Flu). Centers for Disease Control and Prevention. November 2, 2021. Archived from the ...
Influenza C virus
Pattison; McMullin; Bradbury; Alexander (2008). Poultry Diseases (6th ed.). Elsevier. pp. 317. ISBN 978-0-7020-28625. "Types of ... Influenza Viruses". Influenza (Flu). Centers for Disease Control and Prevention. November 2, 2021. Archived from the original ...
Gallibacterium
Pattison, Mark; McMullin, Paul; PhD, Paul; Alexander, Dennis (2007). Poultry Diseases. Elsevier Health Sciences. ISBN ...
Addiction
Bettinardi-Angres K, Angres DH (July 2010). Alexander M (ed.). "Understanding the Disease of Addiction". Journal of Nursing ... It sends a strong message to the public that American medicine is committed to providing expert care for this disease and ... Translation of therapeutic vaccines for addiction, cancer, or other chronic noncommunicable diseases has been slow because only ... "Overdose Deaths Accelerating During Covid-19". Centers For Disease Control Prevention. 18 December 2020. Retrieved 10 February ...
Pott disease
English poets Alexander Pope and William Ernest Henley both had Pott disease. Anna Roosevelt Cowles, sister of President ... The disease is named after Percivall Pott, the British surgeon who first described it in the late 18th century. Blood tests - ... Pott disease is tuberculosis of the spine, usually due to haematogenous spread from other sites, often the lungs. The lower ... Morton, the railroad magnate in the film Once Upon a Time in the West, has the disease and needs crutches to walk. Imogen, in ...
Deaths in January 2003
Julie Alexander, 64, British model and actress, Alzheimer's disease. Horace Hahn, 87, American actor. Peter Guy Ottewill, 87, ... Joan Franks Williams, 72, American composer, complications from Parkinson's disease. ...
List of pathologists
... see Alexander disease). Dame Ingrid Allen, Northern Irish neuropathologist. Friedrich August von Ammon (1799-1861), German ... Alexander A. Maximow (1874-1928), Russian-American scientist, histologist and embryologist. John McCrae (1872-1918), Canadian ... William Boog Leishman (1865-1926), English authority on the pathology of human parasitic diseases (see leishmaniasis) George ... Adolf Weil (1848-1916), German physician and pathologist (see Weil's disease). Ronald S. Weinstein (1938-2021), American ...
Murray Sanders
As a result, the condition became informally known as Sanders disease; however, this terminology is no longer used by ... Sanders would also administer MNT treatment on test subjects in Havana as a possible remedy for polio. Sanders was one of the ... Sanders later invited Ishii to Fort Detrick to lecture officers on the findings made by Unit 731. Sanders has been harshly ... cite web}}: Missing or empty ,title= (help) "Sanders disease". TheFreeDictionary.com. Retrieved 2022-09-22. (CS1 errors: ...
Deaths in August 2012
Kapu Rajaiah, 87, Indian painter, complication of Parkinson's disease. Alexander Saxton, 93, American novelist and historian. ... Cullen, Sandy; Worland, Gayle (31 August 2012). "Former U.S. District Judge Shabaz dies at 81". Wisconsin State Journal. ... Neville Alexander, 75, South African revolutionary and linguist, cancer. Aurora Bautista, 86, Spanish film actress. Malcolm ... Carl Davis, 77, American record producer ("Duke of Earl", "(Your Love Keeps Lifting Me) Higher and Higher"), lung disease. Tom ...
Glial fibrillary acidic protein
GeneReviews/NCBI/NIH/UW entry on Alexander disease OMIM entries on Alexander disease Glial Fibrillary Acidic Protein at the US ... "Alexander Disease". Medical College of Wisconsin. Hagemann TL, Connor JX, Messing A (October 2006). "Alexander disease- ... Chen YS, Lim SC, Chen MH, Quinlan RA, Perng MD (October 2011). "Alexander disease causing mutations in the C-terminal domain of ... GFAP therefore plays an important role in the pathogenesis of Alexander disease. Notably, the expression of some GFAP isoforms ...
2009 New Year Honours
For voluntary service to People with Coronary Heart Disease. Alexander Gill. For services to the fishing community in Kingston- ... Alexander Crombie, Group Chief Executive, Standard Life. For services to the Insurance Industry in Scotland. Dr. Andrew Cubie, ... Professor Alan Alexander Paterson, Professor of Law, Strathclyde University. For services to Legal Education and to Law. Adam ... David Alexander James Hepworth, Q.G.M., lately Senior Investigations Adviser, British Embassy, Kabul. For services to the ...
Eimeria meleagridis
Alexander, DJ (eds.). Poultry diseases (6th ed.). Edinburgh: Elsevier/Butterworth-Heinemann. pp. 451-452. ISBN 978-0-7020-2862- ... The parasite causes disease in the cecum, where, on post-mortem examination (necropsy), a cream-colored exudate is seen. EM, ... Eimeria meleagridis is a species of coccidia found worldwide, which causes mild disease in young turkeys aged 4-8 weeks. ... ISBN 0-8391-0066-3. Trees, AJ (2008). "Chapter 39: Parasitic diseases: Turkey coccidiosis". In Pattison, M; McMullin, PF; ...
Deaths in February 2020
Alexander Skvortsov, 65, Russian ice hockey player, Olympic champion (1984). Fernando Suarez, 52, Filipino Roman Catholic ... Taty Sumirah, 68, Indonesian badminton player, 1975 Uber Cup winner, lung disease. Jimmy Thunder, 54, Samoan-born New Zealand ... Wichie Torres, 67, Puerto Rican painter, cardiovascular disease. Grazia Volpi, 78, Italian film producer (Caesar Must Die, ... Henry Akin, 75, American basketball player (New York Knicks, Seattle SuperSonics, Kentucky Colonels). Duane Alexander, 79, ...
Epidemiological transition
Mercer, Alexander (2014), Infections, Chronic Disease, and the Epidemiological Transition. A New Perspective, Rochester, NY: ... Such a transition can account for the replacement of infectious diseases by chronic diseases over time due to increased life ... With fewer people dying from infectious diseases, there is a rising prevalence of chronic and/or degenerative diseases in the ... The global burden of disease website provides visual comparisons of the disease burdens of countries and the changes over time ...
2021 Birthday Honours
For services to the Prevention and Treatment of Heart Disease. Michael Alexander Frederik Des Tombe. Deputy Director, ... Sally Alexander. Headteacher and Proprietor, Kimichi School, Birmingham. For services to Education. Dr. John Alexander. ... Professor, Infectious Disease Epidemiology, Imperial College London. For services to Infectious Disease Control and ... Director, Centre of Excellence in Infectious Disease Research. For services to Infectious Diseases Research during the Covid-19 ...
SUNY Downstate Medical Center
Alexander Skene, MD - authority on women's diseases; discovered the paraurethral glands known as Skene's ducts (1880). Robert L ... Alzheimer's Disease Research Program Brooklyn Center for Health Disparities Center for Biomedical Imaging Center for ... and Alzheimer's disease; Adult/pediatric emergency services: the ER receives more than 68,906 patient visits a year [2010 data ...
List of Dutch inventions and innovations
Katz, Jay; Capron, Alexander Morgan (1975). Catastrophic Diseases: Who Decides What?, p. 35-36 Simmons, John G. (2002). Doctors ... It is a life support treatment and does not treat disease. On 12 December 1957, Kolff implanted an artificial heart into a dog ... Sandy; Nunnally, Sara (2011). Barbarians of Wealth: Protecting Yourself from Today's Financial Attilas, p. 57-58 Rolland, Gail ...
Castleman disease
van Rhee, Frits; Voorhees, Peter; Dispenzieri, Angela; Fosså, Alexander; Srkalovic, Gordan; Ide, Makoto; Munshi, Nikhil; Schey ... Castleman disease is named after Benjamin Castleman, who first described the disease in 1956. The Castleman Disease ... Whether Castleman disease should be considered an autoimmune disease, cancer, or infectious disease is currently unknown. ... Diseases other than Castleman disease can present with similar histologic findings in lymph node tissue, including: Infectious ...
SPG15 (disease)
Alexander; Denora, Paola; Fernandez, José; Elleuch, Nizar (April 2008). "Identification of the SPG15 gene, encoding spastizin, ... "Spastic paraplegia 15 - About the Disease - Genetic and Rare Diseases Information Center". rarediseases.info.nih.gov. Retrieved ... The disease also affects the upper limbs, and includes additional symptoms, which makes this type of HSP a complicated type ( ... The disease is characterised by progressive spasticity that starts within the lower extremities and spreads to the upper body ...
Farber disease
Mitchell, John; Solyom, Alexander; Makay, Balahan; Arslan, Nur; Batu, Ezgi Deniz; Ozen, Seza; Hügle, Boris; Schuchman, Edward; ... Disease onset is typically in early infancy but may occur later in life. Children who have the classic form of Farber disease ... "Farber disease". rarediseases.info.nih.gov. Genetic and Rare Diseases Information Center (GARD) - an NCATS Program. Elsea, SH; ... Siblings of individuals with Farber disease have a 25% chance to also have Farber disease, a 50% chance to be a carrier like ...
Jon Stoessl
Alexander Jon Stoessl is a Canadian neurologist and Parkinson's disease researcher. He is the director of the Pacific ... In 2001, Stoessl published a paper in Science which found that the placebo effect in Parkinson's disease might be due to ... Stoessl, Alexander Jon; Bushnell, Mary Catherine; Schulzer, Michael; Mak, Edwin; Troiano, Andre R.; Nandhagopal, R. (2010). " ... Parkinson's disease researchers, University of British Columbia faculty, University of Western Ontario alumni, Members of the ...
St. Vincent (film)
Donna Mitchell as Sandy MacKenna, Vincent's wife who has Alzheimer's disease. Kimberly Quinn as Ana, a nurse at Sandy's nursing ... After staff in Sandy's nursing home have told him he is behind on fees and Sandy will be moved, Vincent steals money from ... His wife, Sandy, has Alzheimer's and no longer recognizes him, but he poses as a doctor to visit her and does her laundry. ... Vincent is confronted in his home by loan sharks Zucko and Antwan who attempt to take Sandy's jewelry. Vincent suddenly falls ...
Rosenthal fiber
Its presence is associated with either pilocytic astrocytoma (more common) or Alexander's disease (a rare leukodystrophy). They ... July 1, 2016). "Composition of Rosenthal Fibers, the Protein Aggregate Hallmark of Alexander Disease". Journal of Proteome ...
What Makes a Family
The couple handles the disease for several years until Sandy dies. Following her death, Sandy's parents (Anne Meara and Al ... Brooke Shields as Janine Nielssen Cherry Jones as Sandy Cataldi Anne Meara as Evelyn Cataldi Al Waxman as Frank Cataldi Whoopi ... After the birth of their daughter Heather, Sandy is diagnosed with systemic lupus when she collapses at the baby's christening ... Janine Nielsen (Brooke Shields) and her partner, Sandy Cataldi (Cherry Jones), elect to conceive a baby via artificial ...
Sherwood Gorbach
"Alexander Fleming Award Winners". Infectious Diseases Society of America. Retrieved 15 May 2018. Wormser, Gary P.; Finch, ... He was awarded the Alexander Fleming Award for Lifetime Achievement from the Infectious Diseases Society of America in 2007. D ... 2014 update by the infectious diseases society of America". Clinical Infectious Diseases. 59 (2): 147-159. doi:10.1093/CID/ ... He was editor-in-chief of the journal Clinical Infectious Diseases from 2000 to 2016. He graduated from Brandeis University in ...
Anton Chekhov
Letter to brother Alexander, 2 January 1889, in Malcolm 2004, p. 102. Another insight into Chekhov's childhood came in a letter ... Chekhov died on 15 July 1904 at the age of 44 after a long fight with tuberculosis, the same disease that killed his brother. ... Letter to brother Alexander, 20 November 1887. Letters of Anton Chekhov. Petr Mikhaĭlovich Bit︠s︡illi (1983), Chekhov's Art: A ... ISBN 978-0-8101-1460-9. While Anton did not turn into the kind of militant atheist that his older brother Alexander eventually ...
Chilean art
Worked with the father of modern geography, Alexander von Humboldt. Raymond Monvoisin = French portrait painter, contributed to ... causing many to die young from diseases such as malaria and tuberculosis. The 13 Generation emerged from the country's poorest ... Alexander Simón, Giovatto Molinelli and Theodor Ohlsen. The Chilean precursors of Chilean painting were, like their foreign ...
Lane Seminary
Horace Bushnell Amos Dresser Alexander Duncan, not to be confused with Alexander Duncan (politician), from Cincinnati Hiram ... First of all, the disease rates among the new colonists were the highest since accurate record-keeping began. Over 50% of them ... died of malaria and other diseases. Particularly telling to Gerrit Smith, an abolitionist philanthropist, was that the American ...
Ereshkigal
ISBN 0-292-70794-0. Heidel, Alexander (1949). The Gilgamesh Epic and Old Testament Parallels. University of Chicago Press. ISBN ... had an entourage of minor war gods and disease demons instead. The idea of Nergal and Ereshkigal as a couple likely developed ...
Fifth Street Historic District
Smith, a Missouri native who graduated from Lincoln University in 1888, married Clara Alexander of Lynchburg. By 1911, they had ... He was one of the first African American physicians to use sulfa drugs to treat venereal diseases, a serious health problem ...
New Delhi metallo-beta-lactamase 1
Centers for Disease Control Prevention (CDC) (25 June 2010). "Detection of Enterobacteriaceae Isolates Carrying Metallo-Beta- ... Chen, Lei; Todd, Randall; Kiehlbauch, Julia; Walters, Maroya; Kallen, Alexander (13 January 2017). "Notes from the Field: Pan- ... The British journal The Lancet refused to publish a rebuttal from the Indian National Centre for Disease Control, claiming lack ... the Centers for Disease Control and Prevention (CDC) stated that "All three U.S. isolates were from patients having received ...
Cervical cancer
Dunne EF, Park IU (December 2013). "HPV and HPV-associated diseases". Infectious Disease Clinics of North America. 27 (4): 765- ... Alexander ER (June 1973). "Possible etiologies of cancer of the cervix other than herpesvirus". Cancer Research. 33 (6): 1485- ... Papillomavirus-associated diseases, Sexually transmitted diseases and infections, Wikipedia medicine articles ready to ... In advanced disease, metastases may be present in the abdomen, lungs, or elsewhere. Symptoms of advanced cervical cancer may ...
Black genocide
This topic is also explored in Michelle Alexander's The New Jim Crow. Alexander argues that, despite many Americans wanting to ... prostitution and sexually transmitted diseases. Other injustices included unsafe housing, malnutrition and the over- ... Alexander writes that there has been a "systemic breakdown of black and poor communities devastated by mass unemployment, ... ISBN 978-0-674-73723-5. OCLC 926061456.{{cite book}}: CS1 maint: multiple names: authors list (link) Alexander, Michelle (2010 ...
Benjamin Franklin
Alexander Dallas Bache of the University of Pennsylvania, the law of the effect of heat on the conduction of bodies otherwise ... Infectious disease deaths in Pennsylvania, Les Neuf Sœurs, Masonic Grand Masters, Members of the American Philosophical Society ... Hopes for a peaceful solution ended as he was systematically ridiculed and humiliated by Solicitor-General Alexander Wedderburn ... Respiratory disease deaths in Pennsylvania, Rhetoric theorists, Scientists from Boston, Scientists from Philadelphia, Signers ...
Affenpinscher
Retrieved March 23, 2007 The Affenpinscher Club UK Gough, Thomas (2008). Breed predispositions to disease in dogs and cats. ... https://doi.org/10.1111/j.1748-5827.1995.tb02915.x Evans, Howard E.; de Lahunta, Alexander (August 7, 2013). Miller's Anatomy ...
Resource curse
Banana republic Dutch disease Exploitation colonialism Freight equalization policy in India High-level equilibrium trap Passive ... Black, Dan; McKinnish, Terra; Sanders, Seth (2021-06-07). "Tight Labor Markets and the Demand for Education: Evidence from the ... Real exchange rate increases, through capital inflows or the "Dutch disease" can make this appear an attractive option by ... All of these countries are considered "resource-cursed". Dutch disease makes tradable goods less competitive in world markets. ...
Brian R. Murphy
Alexander C. Schmidt, et al, Respiratory syncytial virus and other pneumoviruses: a review of the international symposium-RSV ... Journal of Infectious Diseases. 182(5): pgs. 1331-1342 Collins PL, Hill MG... Murphy BR (1995). Production of infectious human ... He moved to the National Institutes of Health in 1970 as a research associate in the Laboratory of Infectious Diseases within ... In 2001, he became co-chief of the Laboratory of Infectious Diseases with Robert H. Purcell. He retired from the National ...
Daniel J. Klionsky
He is the Alexander G. Ruthven Professor of Life Sciences and professor of molecular, cellular, and developmental biology at ... neurodegenerative diseases and other areas of human health." As a result, Klionsky was singled out by Thomson Reuters as a ... neurodegenerative diseases, and other areas of human health. Klionsky was born in 1958 in California. Although he enjoyed ... where he was named the Alexander G. Ruthven Professor of Life Sciences in 2006. During his tenure at UMich, Klionsky became " ...
Politicization of science
Tyson, Alec; Funk, Cary; Kennedy, Brian (1 March 2022). "Americans Largely Favor U.S. Taking Steps To Become Carbon Neutral by ... weekly Centers for Disease Control scientific reports and attempted to silence the government's most senior infectious disease ... Alexander Graham Bell, the inventor of the telephone; among other prominent people. The level of support for eugenics research ... to the Advisory Committee to the director of the Centers for Disease Control. According to the report, information about ...
Gia Carangi
Believed to have contracted it from a contaminated needle, she became one of the first famous women to die of the disease. Her ... Modeling offers soon ceased and her fashion industry friends, including Sandy Linter, refused to speak to her, fearing their ... becoming one of the first famous women to die of the disease. Her funeral was held on November 23 at a small funeral home in ... including Sandy Linter, and footage of actress-screenwriter Zoë Lund, herself a heroin addict, who had been commissioned to ...
Brain ischemia
Moyamoya disease has also been identified as a potential cause for brain ischemia. Moyamoya disease is an extremely rare ... Hossmann, Konstantin-Alexander; Zimmermann, Volker (1974). "Resuscitation of the monkey brain after 1 H complete ischemia. I. ... Brain ischemia has been linked to a variety of diseases or abnormalities. Individuals with sickle cell anemia, compressed blood ... Sparks, Gareth (2002). "What is Moyamoya disease?". eSSORTMENT. Archived from the original on 2009-03-27. Retrieved 2009-04-13 ...
Saratov State Medical University
"In memory of the scientist :: BOGOMOLETS Alexander Alexandrovich". nasb.gov.by. Retrieved 2020-09-10. Andreev, Alexander ... and cosmetology Children's diseases of the medical faculty Foreign languages Infectious diseases Infectious diseases in ... general medical practice and preventive medicine Propaedeutics of internal diseases Propaedeutics of childhood diseases, ... IAroslavtsev Alexander Leontievich (April 1937 - December 1937) Samoilova Elena Evgenievna (1937-1938) V.N. Abramenko (1938- ...
History of the Jews in Poland
The new czar, Alexander III, blamed the Jews for the riots and issued a series of harsh restrictions on Jewish movements. ... During the next year and a half, Jews from smaller cities and villages were brought into the Warsaw Ghetto, while diseases ( ... In 1804, Alexander I of Russia issued a "Statute Concerning Jews", meant to accelerate the process of assimilation of the ... In the same year, Alexander, when he was the Grand Duke of Lithuania, followed the 1492 example of Spanish rulers and banished ...
City of Glen Eira
A clean water supply and sanitary removal of sewage was critical last century because of outbreaks of disease, such as typhoid ... Dirt tracks wound through the swamps and sandy heaths of the district. They were constantly damaged by farmers' cart wheels, ... For more than a century, the sandy soil of Moorabbin provided metropolitan Melbourne with much of its fruit and vegetables. ...
Harold Hitz Burton
He was diagnosed with Parkinson's disease. The shaking in his left arm had become so severe by the start of 1958 that he ... The couple had three children: Christine, Virginia (1909-1968), and Alexander Ross Burton. The half siblings developed warm ... Burton publicly announced that he was suffering from Parkinson's disease. He retired on the advice of physicians, who said the ... He died on October 28, 1964, in Washington, D.C., from complications arising from Parkinson's disease, kidney failure, and ...
Pulmonary agenesis
So, there is a considerable time delay for the disease to be diagnosed, though it's capable of detection since birth or even ... Pulmonary hypoplasia Maltz, David; Nadas, Alexander (1968). "Presentation of Eight New Cases and Review of the Literature". ...
Alexander Russell Simpson
"Professor Alexander Russell Simpson, 1835 - 1916. Professor of Midwifery and Diseases of Women and Children at Edinburgh ... Sir Alexander Russell Simpson FRCPE FRSE LLD (20 April 1835-6 April1916) was a Scottish physician and Professor of Midwifery at ... Debrett's House of Commons and Judicial Bench, 1916 "SIR ALEXANDER RUSSELL SIMPSON, Kt., M.D., D.Sc.(Hon. Causa), LL.D". Br Med ... "Simpson, Sir Alexander Russell, (30 April 1835 - 6 April 1916)", Who Was Who, Oxford University Press, 1 December 2007, doi: ...
College of West Africa
He contracted malaria and died of the disease on July 21, 1833 after three months of decline. Such tropical diseases had a high ... Alexander P. Camphor was appointed principal in 1896. At the end of his first year of administration, he began the re- ... Alexander B. Cummings Jr., businessman, politician. Patricia Jabbeh Wesley, poet and writer. George Klay Kieh, educator, ... Charles McArthur Emmanuel, son of Charles Taylor Thomas Alexander Goshua, II, politician Ann Wilkins (1806-1857), American ...
Bougainville campaign
8,500 Japanese were killed at the same time, while disease and malnutrition killed another 9,800 and some 23,500 troops and ... The ships under Wilkinson's command would disembark the I Marine Amphibious Corps, commanded by Major General Alexander ... Long's figures are quoted in the narrative, totalling 16,700 combat deaths and 26,400 deaths from disease and malnutrition. ... Footnotes Figure includes deaths from all causes: combat, disease, starvation, and accident. The Australians counted 21,000 to ...
Maslama ibn Abd al-Malik
ISBN 978-0-88706-721-1. Kazhdan, Alexander, ed. (1991). The Oxford Dictionary of Byzantium. Oxford and New York: Oxford ... into handing over or destroying a significant part of his hoarded supplies-and the army began to suffer from hunger and disease ...
Robert Byrne (chess player)
Deaths from Parkinson's disease, Indiana University faculty, Neurological disease deaths in New York (state), People from ... He did represent the U.S. in team matches against the Soviet Union at New York in 1954 (losing 1½-2½ to Alexander Kotov), and ... Byrne died in 2013 at his home in Ossining, New York, from Parkinson's disease. David Bronstein vs Robert Byrne, Helsinki ...
Woodrow Wilson
Starring Alexander Knox and directed by Henry King, Wilson is considered an "idealistic" portrayal of the title character. The ... The health of Wilson's wife, Ellen, declined after he entered office, and doctors diagnosed her with Bright's disease in July ... His mind remained relatively clear; but he was physically enfeebled, and the disease had wrecked his emotional constitution and ... Neurological disease deaths in Washington, D.C., New Jersey Democrats, Nobel Peace Prize laureates, People from Kalorama ( ...
Medical malpractice in the United States
Cristina Corduneanu-Huci, Alexander Hamilton, and Issel Masses-Ferrer, The political economy of healthcare litigation: model ... Using these numbers, medical malpractice is the third leading cause of death in the United States, only behind heart disease ... Likewise, damage can occur without negligence, for example, when someone dies from a fatal disease. In cases involving suicide ... For example, the Centers for Disease Control and Prevention currently says that 75,000 patients die annually, in hospitals ...
Ahoy (greeting)
Alexander Graham Bell initially suggested that the standard greeting when answering a telephone should be 'ahoy', but instead ' ... Czech prostitutes from bars in the harbour warned their customers of their occupational disease syphilis with the wordplay "A ...
Battery M, 2nd Illinois Light Artillery Regiment
Expedition up Big Sandy Valley to Beaver Creek June 14-July 22. Expedition to Gladesville, Va., July (Section). Moved to ... Battery lost during service 5 Enlisted men killed and mortally wounded and 16 Enlisted men by disease. Total 21. List of ...
Alexander disease: MedlinePlus Genetics
Alexander disease is a rare disorder of the nervous system. Explore symptoms, inheritance, genetics of this condition. ... medlineplus.gov/genetics/condition/alexander-disease/ Alexander disease. ... Zang L, Wang J, Jiang Y, Gu Q, Gao Z, Yang Y, Xiao J, Wu Y. Follow-up study of 22 Chinese children with Alexander disease and ... Alexander disease is a rare disorder of the nervous system. It is one of a group of disorders, called leukodystrophies, that ...
Antisense suppression of glial fibrillary acidic protein as a treatment for Alexander disease
... Hagemann TL, Powers B, Mazur C, ... Antisense suppression of glial fibrillary acidic protein as a treatment for Alexander disease. Hagemann, PhD, T. L., and A. ... Antisense Suppression of Glial Fibrillary Acidic Protein As a Treatment for Alexander Disease. ... Antisense suppression of glial fibrillary acidic protein as a treatment for Alexander disease ...
Dr. Alec Musten, Cardiovascular Disease | Jenkintown, PA | WebMD
In Memoriam: Alexander I. Klimov (1943-2013) - Volume 19, Number 5-May 2013 - Emerging Infectious Diseases journal - CDC
Mahy B. In Memoriam: Alexander I. Klimov (1943-2013). Emerging Infectious Diseases. 2013;19(5):842. doi:10.3201/eid1905.im0266. ... Brian W. J. Mahy, Emerging Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, Mailstop D61, ... Centers for Disease Control and Prevention. CDC twenty four seven. Saving Lives, Protecting People ... The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. ...
"Extreme Sawtooth-Sign in Motor Neuron Disease (MND) Suggests Laryngeal" by Deanna Britton, Alexander Kain et al.
The impact of laryngeal dysfunction on airflow has not been well characterized in motor neuron disease (MND). This study aimed ... Alexander Kain, Oregon Health & Science University. Yu-Wen Chen, National Taiwan University. Jack Wiedrick, OHSU-PSU School of ... The impact of laryngeal dysfunction on airflow has not been well characterized in motor neuron disease (MND). This study aimed ... Extreme Sawtooth-Sign in Motor Neuron Disease (MND) Suggests Laryngeal Resistance to Forced Expiratory Airflow ...
Sub-Saharan Healthcare: Global Health in Tanzania by Alexander Barna, Immunology and Infectious Disease major - Penn State...
Sub-Saharan Healthcare: Global Health in Tanzania by Alexander Barna, Immunology and Infectious Disease major. ... Sub-Saharan Healthcare: Global Health in Tanzania by Alexander Barna, Immunology and Infectious Disease major ... Sub-Saharan Healthcare: Global Health in Tanzania by Alexander Barna, Immunology and Infectious Disease major ... ecology of infectious disease, etc. Something unique to this location for fieldwork was that I lived on campus at Ruaha ...
Book Doctors for Alexander Disease Appointment - Consult Doctors for Alexander Disease, Schedule Consultation, Book Specialist ...
Consult Doctors for Alexander Disease and book appointment, view consultation schedules, book specialists, view hospital ... Alexander Disease. Alexander Disease. Below is list of specialists whom can be consulted for Alexander Disease from our partner ... Alexander Disease, Krabbe Disease, Limb-Girdle Muscular Dystrophy, Complex Regional Pain Syndrome (CRPS), Refsum Disease ... Consulted For: Limb-Girdle Muscular Dystrophy, Charcot-Marie-Tooth Disease, Moyamoya Disease, Stroke, Meningioma - See all ...
Tobacco Induced Diseases - Author Alexander Osarogue
Alexander disease | 5-Minute Pediatric Consult
Alexander disease answers are found in the 5-Minute Pediatric Consult powered by Unbound Medicine. Available for iPhone, iPad, ... Alexander disease is a topic covered in the 5-Minute Pediatric Consult. To view the entire topic, please log in or purchase a ... "Alexander Disease." 5-Minute Pediatric Consult, 8th ed., Wolters Kluwer, 2019. Pediatrics Central, peds.unboundmedicine.com/ ... pedscentral/view/5-Minute-Pediatric-Consult/617875/all/Alexander_disease. Alexander disease. In: Cabana MDM, ed. 5-Minute ...
Alexander Disease Clinical Study Treatment Trial - Alex - The Leukodystrophy Charity
... in patients with Alexander disease.. Alexander disease patients experience progressive deterioration, leading to severe ... Childhood onset is associated with more serious disease, with patients rarely surviving beyond adolescence. Alexander disease ... Alexander Disease Clinical Study Treatment Trial. Ionis Pharmaceuticals announced it has initiated a pivotal clinical study of ... Ionis initiates pivotal clinical study of novel antisense medicine to treat patients with Alexander disease , Ionis ...
Alexander Disease-an MRI Diagnosis - New Indian Journal of Pediatrics
Alexander disease (AD) is a rare, lethal leukodystrophy of the central nervous system of unknown etiology. AD is characterized ... Alexander Disease. In: Pagon RA, Bird TD, Dolan CR, et al., editors. GeneReviews?? [Internet] Seattle (WA): University of ... The disease can now be detected by genetic diagnosis. We report a case of 8 year old child with onset of disease at the age of ... Alexander disease (AD) is a rare, progressive, autosomal dominant leukodystrophy affecting the central nervous system (CNS) ...
Nepro Alexander -
Welcome to the myDaVita Kidney Disease and Dialysis Forums
Gum Disease Treatment in Sandy, UT | Periodontal Treatment
For gum disease treatment & periodontal services in Sandy, book a consultation today. ... For periodontal disease treatment, we will typically examine the gums to determine the level of disease and the best course of ... Most often, periodontics is needed when you have gum disease. There are a variety of gum disease treatments available, such as ... If these pockets are very deep, we may recommend that you begin periodontal disease, or gum disease, treatment. With early ...
black berries - Sandy's Plants, Disease and Insect ID Blog
Dentist Sandy Springs: Prevention of Periodontal Disease - the right smile
If gum disease is diagnosed, we offer in-house treatment or referral to a periodontist, which is a dentist… ... Tagged Dentist Sandy Springs, Oral Health, Periodontal disease, Sandy Springs Dental Post navigation. Previous postChoosing an ... Dentist Sandy Springs: Prevention of Periodontal Disease. May 15, 2017. August 12, 2019. by Drs. Novy and ZoAnna Bock and Hanna ... Periodontal disease will not go away by itself. Preventing and treating the disease through good oral healthcare in the early ...
Macrocephaly: Causes, symptoms, risks, diagnosis & treatment
Propensity for paternal inheritance of de novo mutations in Alexander disease - Alexander Disease Lab - UW-Madison
Propensity for Paternal Inheritance of De Novo Mutations in Alexander Disease. Li R, Johnson AB, Salomons GS, van der Knaap MS ... Propensity for paternal inheritance of de novo mutations in Alexander disease. Messing, VMD, PhD, A. Propensity for Paternal ... Propensity for paternal inheritance of de novo mutations in Alexander disease ... Propensity for paternal inheritance of de novo mutations in Alexander disease. Human Genetics, 119, 137-44. ...
mikenov on Twitter: Alexander Yuk Ching Ma images.app.goo.gl/chGnQUprjs84Go… | The Disease X-19
Disease X-19: Covid-19 News Review *Disease X-19 News Review In Brief ... Posts - Disease X-19 - diseasex19.org *Disease X-19 - Posts In Brief - 250 ... Disease X-19: Covid-19 News Review *Disease X-19 News Review In Brief ... Posts - Disease X-19 - diseasex19.org *Disease X-19 - Posts In Brief - 250 ...
Resource Library - Feline Heartworm Disease | Olney-Sandy Spring Veterinary Hospital, Sandy Spring MD
See more about feline heartworm disease in our resource library. ... Olney Sandy Spring Veterinary Hospital Your Other Family Doctor ... Olney-Sandy Spring Veterinary Hospital does not provide veterinary medical services or guidance via the Internet. Please ... Copyright © 2022 Olney-Sandy Spring Veterinary Hospital. All rights reserved. Veterinary Website by Beyond Indigo Pets ...
Bugiani M[au] - Search Results - PubMed
Alexander Disease. Tavasoli A, Armangue T, Ho CY, Whitehead M, Bornhorst M, Rhee J, Hwang EI, Wells EM, Packer R, van der Knaap ... Childhood white matter disorders: much more than just diseases of myelin. Bugiani M, van der Knaap MS. Bugiani M, et al. Acta ... Disease characteristics of MCT8 deficiency: an international, retrospective, multicentre cohort study. Groeneweg S, van Geest ...
CDC's early response to AIDS : preserving history, December 1, 2017 3:00 PM, Alexander D. Langmuir Auditorium, Centers for...
Centers for Disease Control and Prevention (U.S.). David J. Sencer CDC Museum. ; Emory University. Libraries & Information ... Centers for Disease Control and Prevention (U.S.). David J. Sencer CDC Museum. ; Emory University. Libraries & Information ... The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. ... On June 5, 1981, CDC published a report in the MMWR describing requests for the drug pentamidine to treat a deadly disease ...
IMSEAR at SEARO: Alexander's disease: a case report of a biopsy proven case.
Jemeen Sreedharan - Research Portal, King's College, London
Preventing Chronic Disease: July 2009: 08 0130
Janet Alexander, MSPH; Edward L. Baker Jr, MD, MPH. Suggested citation for this article: Porterfield DS, Reaves J, Konrad TR, ... Centers for Disease Control and Prevention. National Center for Chronic Disease Prevention and Health Promotion. United States ... Chronic disease overview. Atlanta (GA): National Center for Chronic Disease Prevention and Health Promotion, Centers for ... More work is needed to measure LHD performance in other chronic disease areas, such as obesity, cardiovascular disease, and ...
Embark Dog DNA Test - Breed
Sleep Apnea May Increase Women's Risk of Heart Disease - Sandy Springs Atlanta, GA: Atlanta ENT, Sinus & Allergy Associates, P...
Trusted Board Certified Otolaryngologist serving Sandy Springs Atlanta, GA. Visit our website to book an appointment online: ... Atlanta ENT, Sinus & Allergy Associates, P.C. Contents Patient Education Sleep Apnea May Increase Womens Risk of Heart Disease ... Sleep Apnea May Increase Womens Risk of Heart Disease * Facts about Sleep Apnea ... Heart disease is only one potential complication that can arise from this problem. It has been linked to diabetes, high blood ...
lex : Dictionary / Wörterbuch (BEOLINGUS, TU Chemnitz)
lex : Deutsch - Englisch Übersetzungen und Synonyme (BEOLINGUS Online-Dictionary, TU Chemnitz) ... lex : German - English translations and synonyms (BEOLINGUS Online dictionary, TU Chemnitz) ... lex domicilii. Wohnsitzrecht {n}; Recht des Domizils [jur.]. law; lex (in compounds) (a particular legal area) Recht {n}; Lex { ... lex , lex. Word division: Lex. Tip: Gender of German nouns: {m} = der, {f} = die, {n} = das, {pl} = die. ...
In Memoriam: Alexander I. Klimov (1943-2013) - Volume 19, Number 5-May 2013 - Emerging Infectious Diseases journal - CDC
Mahy B. In Memoriam: Alexander I. Klimov (1943-2013). Emerging Infectious Diseases. 2013;19(5):842. doi:10.3201/eid1905.im0266. ... Brian W. J. Mahy, Emerging Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, Mailstop D61, ... The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. ... Mahy, B. (2013). In Memoriam: Alexander I. Klimov (1943-2013). Emerging Infectious Diseases, 19(5), 842. https://doi.org/ ...
Macrocephaly | Harvard Catalyst Profiles | Harvard Catalyst
Mechanisms of Disease: astrocytes in neurodegenerative disease | Nature Reviews Neurology
Alzheimers disease, Huntingtons disease and Parkinsons disease, and it is presumed that neurodegeneration results in the ... The term neurodegenerative disease refers to the principal pathology associated with disorders such as amyotrophic lateral ... and mouse models of neurodegenerative diseases have also revealed astrocyte-specific pathologies that contribute to ... clinical findings seen in patients with these diseases. Decades of pathological and physiological studies have focused on ...
20192020Parkinson'sAlzheimer's Disease2022World Health OrganEmerging InfectioPhytophthora or RhizoctoniaPeriodontal diseaseSymptomsCongenitalCenters for DisPrevalenceENFERMEDAD DE ALEXANDER2001Kidney DiseasePatients1997SearchPreventableDiagnosis and treatmentNeurologicalSexually transmitImmunologyClinicalChronic diseasesInfectious diseaseAlexander's DiseaseAstrocytesAutosomal dominantMutationsGeneticsLangmuirUpper extremityEtiologyAdultsOnsetDevelopmental disabilities1996GingivitisGFAPSoybeanProgressionAtlantaAbnormalitiesInfectionPediatricsCohortPrevention and treatmentHealth2018FamilialResearch
20193
- We used Sullivan's method to estimate chronic disease-free life expectancy in Algeria using data provided from the Multiple Indicator Cluster Surveys and national life tables published by the Office for National Statistics for 2006, 2012-2013, and 2018-2019. (who.int)
- The gain in life expectancy between 2006 and 2018-2019 was accompanied by a decline in chronic disease-free life expectancy from 62.36 and 57.27 years to 61.13 and 55.64 years for men and women, respectively. (who.int)
- 2019). Global, regional, and national cancer incidence, mortality, years of life lost, years lived with disability, and disability-adjusted life-years for 29 cancer groups, 1990 to 2017: A systematic analysis for the Global Burden of Disease Study. (bsl.nl)
20201
- The Horizon 2020 funded project ALEC - Aging Lungs in European Cohorts - integrates data from long-term studies with high quality spirometry data from different countries and age groups. (swisstph.ch)
Parkinson's23
- The term neurodegenerative disease refers to the principal pathology associated with disorders such as amyotrophic lateral sclerosis, Alzheimer's disease, Huntington's disease and Parkinson's disease, and it is presumed that neurodegeneration results in the clinical findings seen in patients with these diseases. (nature.com)
- Mitochondrial dysfunction has long been demonstrated as a common prominent early pathological feature of a variety of common neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), and Huntington's disease (HD). (mdpi.com)
- Parkinson's disease, Huntington's disease, and HIV can cause these types of dementia. (rxlist.com)
- He specializes in general neurosurgery and surgery for epilepsy, trigeminal neuralgia and movement disorders, including Parkinson's disease. (uthscsa.edu)
- Parkinson's disease (PD) is a devastating neurodegenerative disorder characterized by progressive motor debilitation, which affects several million people worldwide. (springer.com)
- Parkinson's disease (PD) is the most common neurodegenerative movement disorder, estimated to affect 1% of the population over 65 years of age. (springer.com)
- Parkinson's disease (PD) might be a mutual neurodegenerative disease considered by a movement disorder containing rest tremor, bradykinesia, rigidity, and postural instability, and second-leading reason of dementia and is categorized by an advanced loss of dopaminergic neurons within the neural structure alongside the occurrence of intraneuronal α-synuclein-positive enclosures. (stmjournals.in)
- Parkinson's disease: clinical features and diagnosis. (stmjournals.in)
- Past, present, and future of Parkinson's disease: a special essay on the 200th anniversary of the shaking palsy. (stmjournals.in)
- Diagnosis and treatment of Parkinson's disease: a review. (stmjournals.in)
- Alexander, Garrett E. "Biology of Parkinson's disease: pathogenesis and pathophysiology of a multisystem neurodegenerative disorder. (stmjournals.in)
- Dopamine and levodopa prodrugs for the treatment of Parkinson's disease. (stmjournals.in)
- Dopamine-or L-DOPA-induced neurotoxicity: the role of dopamine quinone formation and tyrosinase in a model of Parkinson's disease. (stmjournals.in)
- Emerging treatment approaches for Parkinson's disease. (stmjournals.in)
- Staging of brain pathology related to sporadic Parkinson's disease. (stmjournals.in)
- Progression of tremor in early stages of Parkinson's disease: a clinical and neuroimaging study. (stmjournals.in)
- The role of neurotransmitters in the development of Parkinson's disease‐related psychosis. (stmjournals.in)
- Non-motor features of Parkinson's disease. (stmjournals.in)
- The prominent role of serotonergic degeneration in apathy, anxiety and depression in de novo Parkinson's disease. (stmjournals.in)
- Overview of the cholinergic contribution to gait, balance and falls in Parkinson's disease. (stmjournals.in)
- The non-declaration of non-motor symptoms of Parkinson's disease to health care professionals: an international study using the non-motor symptoms questionnaire. (stmjournals.in)
- MDS research criteria for prodromal Parkinson's disease. (stmjournals.in)
- Practical approach to quality of life in Parkinson's disease: the nurse's role. (stmjournals.in)
Alzheimer's Disease18
- Tony was diagnosed with Alzheimer's disease in 2015, and Josie followed a year later. (denverpost.com)
- What is Alzheimer's disease? (denverpost.com)
- Alzheimer's disease is a brain disorder that slowly degrades a person's memory and thinking skills. (denverpost.com)
- In 1906 Auguste Deter, a woman in her early 50s, became the first person diagnosed with Alzheimer's disease, a form of dementia. (rxlist.com)
- In 1910 the term "Alzheimer's Disease" was formally used. (rxlist.com)
- it is a broad term that characterizes many different conditions, such as Alzheimer's disease, vascular dementia, frontotemporal dementia, and other disorders. (rxlist.com)
- Creutzfeldt-Jakob and Alzheimer's disease are two types of cortical dementia. (rxlist.com)
- Alzheimer's disease, Lewy body dementia, vascular dementia, and frontotemporal dementia are types of progressive dementia. (rxlist.com)
- Alzheimer's disease is a form of primary dementia, which accounts for 50%-70% of all dementia cases. (rxlist.com)
- Alzheimer's disease is a progressive degenerative condition that has devastating implications for those afflicted. (cdc.gov)
- The trend in mortality from Alzheimer's disease (figure 1), has by forgetfulness in early stages and increasingly severe debilitating slowed considerably. (cdc.gov)
- the leveling of the have Alzheimer's disease (1). (cdc.gov)
- Physicians report that Alzheimer's disease caused the death of Ranking of leading causes of death is ordered according to the 21,397 persons in 1996 and contributed to the death of 21,703 addi- number of deaths caused by specific conditions. (cdc.gov)
- This information is from death certificates completed by from Alzheimer's disease in 1996 made Alzheimer's disease the 13th physicians for all deaths in the United States, a fundamental source of leading cause of death for all age groups and 8th leading cause for information on what caused death for the 2.3 million deaths in the United persons 65 years of age or more (4). (cdc.gov)
- The risk of dying from Alzheimer's disease has leveled off in between 1995 and 1996 in the number of deaths from Alzheimer's recent years after rapid increases in the early 1980's and subsequent disease, the disease moved from the 14th to the 13th leading cause slower growth in the 1990's. (cdc.gov)
- the recent leveling in mortality trends from this condition may signal that death certificate diagnoses for Alzheimer's disease are more reliable now. (cdc.gov)
- Sandy Smith, Public recent mortality data on Alzheimer's disease. (cdc.gov)
- For 1997 preliminary data indicate that Alzheimer's disease moved from the 13th to the 12th leading cause, reflecting major decreases in Human immunodeficiency virus infection (HIV) deaths between the two years. (cdc.gov)
20221
- Congenital heart disease through life: Mayo Clinic experts explain changes to expect Nov. 17, 2022, 04:25 p.m. (mayoclinic.org)
World Health Organ2
- Dr Klimov began his career at the Centers for Disease Control and Prevention (CDC), Atlanta, Georgia, USA, following a career of great distinction at the Research Institute for Viral Preparations in Moscow, Russia, where in 1986 he became director of the World Health Organization (WHO) Collaborating Center for Molecular Biology and Genetics of Epidemic and Vaccine Influenza Virus Strains and head of the Laboratory of Genetics of RNA Viruses. (cdc.gov)
- According to data from the world health organization (WHO), to take mild courses of the disease in the Mediterranean for two weeks. (vaccar.biz)
Emerging Infectio4
- Dr Klimov was also a regular reviewer of papers submitted to Emerging Infectious Diseases, the Journal of Clinical Virology, the Journal of Virological Methods, Vaccine, Virology, and Virus Research, and he was a member of the editorial board of Voprosy Virusologii (Russia). (cdc.gov)
- Ebright JR, Altantsetseg T, Oyungerel R. Emerging Infectious Diseases in Mongolia. (cdc.gov)
- Emerging Infectious Diseases , 9 (12), 1509-1515. (cdc.gov)
- Emerging Infectious Diseases , 9 (12), 1516-1522. (cdc.gov)
Phytophthora or Rhizoctonia1
- In these instances, the soybeans have previously been infected with other root rotting diseases including Pythium, Phytophthora or Rhizoctonia root rot. (soybeanresearchinfo.com)
Periodontal disease9
- If these pockets are very deep, we may recommend that you begin periodontal disease, or gum disease, treatment. (fortunionfamilydental.com)
- For periodontal disease treatment, we will typically examine the gums to determine the level of disease and the best course of treatment. (fortunionfamilydental.com)
- When periodontal disease is first diagnosed, one of our recommended treatments is scaling and root planing. (wordpress.com)
- Periodontal disease will not go away by itself. (wordpress.com)
- We are a multi-specialty practice with in-house and referral treatment of periodontal disease. (wordpress.com)
- Literature review: The high prevalence of dental problems such as caries and periodontal disease is still found worldwide, despite the significant reduction. (bvsalud.org)
- Oral diseases, such as dental caries and periodontal disease is still public health problems, especially for some age ranges, gender, socioeconomic levels, education levels, and geographical sites 35 . (bvsalud.org)
- By raising the discussion on periodontal disease, many questions still require further explanation. (bvsalud.org)
- It is not known if the periodontal disease is reducing worldwide. (bvsalud.org)
Symptoms7
- It is not well understood how impaired astroglial cells contribute to the abnormal formation or maintenance of myelin, leading to the signs and symptoms of Alexander disease. (medlineplus.gov)
- It is unclear if screening for peripheral artery disease in people without symptoms is useful as it has not been properly studied. (wikipedia.org)
- The signs and symptoms of peripheral artery disease are based on the part of the body that is affected. (wikipedia.org)
- This must be differentiated from cold agglutinin disease, especially when no symptoms or findings suggest cold-induced acrocyanosis or Raynaud-type phenomenon. (medscape.com)
- It is a chronic and progressive disease characterized predominantly by resting tremors, bradykinesia, muscular rigidity and postural instability, along with several non-motor symptoms [ 1 ]. (springer.com)
- In patients with symptoms of upper respiratory tract, it takes, according to the previous experience of four to eight days to decide if the disease infects the lower respiratory tract, says Witzenrath from Charité. (vaccar.biz)
- See Charcoal Rot , Crop Protection Network Bulletin CPN-1004 for a complete discussion and diagnostic photos of charcoal rot and other soybean diseases with similar symptoms. (soybeanresearchinfo.com)
Congenital11
- Today we will be discussing atrial and ventricular arrhythmia in complex congenital heart disease . (medscape.com)
- Please, can you talk to us about medical management of atrial arrhythmia in congenital heart disease? (medscape.com)
- If you think of the non-congenital heart disease population-that group of patients who are young with otherwise-normal hearts-we usually use class IC drugs or even beta-blockade, [atrioventricular] AV nodal blockers for those. (medscape.com)
- This is distinctly the approach that shouldn't be used for [congenital heart disease patients]. (medscape.com)
- Because reentrant scar-related arrhythmias [occur commonly in] the complex repaired congenital heart disease patient, we want to increase repolarization and break these reentrant flutters. (medscape.com)
- But with complex congenital heart disease, we have to steer away from those. (medscape.com)
- The standard [features], like you said, of an adult after a myocardial infarction don't necessarily relate to complex congenital heart disease. (medscape.com)
- However, the kind of flutter that we see in congenital heart disease patients is something that we call "scar flutter," or-more properly termed-the "intra-atrial reentrant tachycardia. (medscape.com)
- Mayo Clinic researchers develop new treatments for children and adults with congenital heart diseases and study the genetic causes of some of those diseases. (mayoclinic.org)
- Mayo Clinic researchers have published many articles describing the long-term results of treatments for many congenital heart diseases. (mayoclinic.org)
- Mayo Clinic Q and A: Congenital heart disease revision surgery Aug. 24, 2021, 12:29 p.m. (mayoclinic.org)
Centers for Dis13
- Centers for Disease Control and Prevention. (cdc.gov)
- The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. (cdc.gov)
- PATCH, the acronym for Planned Approach to Community Health, is a cooperative program of technical assistance managed and supported by the Centers for Disease Control (CDC). (cdc.gov)
- The Centers for Disease Control and Prevention estimates that in 2013, antibiotic resistance threats caused more that 2 million illnesses and 23,000 deaths in the United States and that in 2011, those threats were responsible for an estimated $20 million in excess health care costs, 8 million additional hospital days, and $35 million in societal costs. (cdc.gov)
- The Centers for Disease Control and Prevention (CDC) has recently updated COVID-19 quarantine and isolation recommendations for healthcare and non-healthcare settings. (cdc.gov)
- The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. (cdc.gov)
- Xan Young, senior technical assistance consultant at AIR, directs the Violence Prevention Technical Assistance Center, funded by the Centers for Disease Control and Prevention. (air.org)
- Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. (cdc.gov)
- The image was captured by Dr. Alexander D. Langmuir, former Chief Epidemiologist at the Centers for Disease Control and Prevention (CDC), and founder of the Disease Investigations branch of the Epidemic Intelligence Service (EIS) in 1951. (cdc.gov)
- Announcer] This program is presented by the Centers for Disease Control and Prevention. (cdc.gov)
- Dr. Rochelle Walensky is the new Director of the Centers for Disease Control and Prevention (CDC) and the Administrator of the Agency for Toxic Substances and Disease Registry. (amazingjews.org)
- The U.S. Centers for Disease Control and Prevention (CDC) will hold its annual Epidemic Intelligence Service (EIS) Conference April 24-27, 2023 in Atlanta. (cdc.gov)
- Visit the U.S Centers for Disease Control and Prevention for more on listeria . (medicalxpress.com)
Prevalence9
- The prevalence of Alexander disease is unknown. (medlineplus.gov)
- A holistic view of the multiple risk factors and their relation to the prevalence of cardiovascular disease (CVD) is necessary to determine a baseline for prevention. (cdc.gov)
- Wasserstein MP, Aron A, Brodie SE, Simonaro C, Desnick RJ, McGovern MM. Acid sphingomyelinase deficiency: prevalence and characterization of an intermediate phenotype of Niemann-Pick disease. (medscape.com)
- The prevalence of neurological diseases has increased rapidly, and they are now the second biggest cause of death globally. (labiotech.eu)
- Introduction and objective: A number of studies have associated prevalence of oral diseases, socioeconomic factors, and dental services in Brazil, and this study aimed to review, in narrative mode, the causal nexus between them. (bvsalud.org)
- In Brazil, these characteristics are exemplified by prevalence estimates found in the last oral health epidemiological survey- SB Brasil 2010 10 , despite of the reduction of caries disease in permanent teeth (DMFT) at the age ranged of 12 years and 15-19 years 10 . (bvsalud.org)
- Although caries disease historically tends to decline in prevalence means, - recorded worldwide 21 and in Brazilian young population 10 -, much remains to be done considering the economic, social, caring, and human consequences of the disease. (bvsalud.org)
- Notwithstanding, in Brazil, especially in North, there is a high extraction rate at the age range of 65-74 years, which may reflect a mutilating characteristic of the care model and also the prevalence of severe disease cases 10 . (bvsalud.org)
- The general aim of this review study is to explore the pertinent literature on findings correlating the prevalence of oral diseases, socioeconomic factors, and dental services and discuss on the consistence and scope of such causal nexus, weighing the importance to guide more resolute oral health politics and services. (bvsalud.org)
ENFERMEDAD DE ALEXANDER1
- La enfermedad de Alexander es una leucoencefalopatía progresiva cuyo sello distintivo es la acumulación generalizada de inclusiones citoplasmáticas denominadas fibras de Rosenthal. (bvsalud.org)
20011
- and the James H. Nakano Award for an outstanding scientific paper, National Center for Infectious Diseases, CDC, in 1996, 2001, and 2005. (cdc.gov)
Kidney Disease6
- Sharon said, "With the onset of Covid-19, we have had to re-think how we can continue with our mission of transforming lives by fighting Kidney Disease - but doing it safely. (socialwhirl.com)
- Sandy said, "One thing remains the same, Kidney Disease continues to strike all ages and is devastating for our friends and family. (socialwhirl.com)
- Since 1999, the dedicated volunteers of KidneyTexas, Inc. have worked in tandem with our generous underwriters to raise over $3.7 million for local efforts to improve the ability to diagnose and manage kidney disease. (socialwhirl.com)
- Performance of soluble Klotho assays in clinical samples of kidney disease. (utsouthwestern.edu)
- Fibroblast growth factor 21 in chronic kidney disease. (utsouthwestern.edu)
- Control of metabolic predisposition to cardiovascular complications of chronic kidney disease by effervescent calcium magnesium citrate: a feasibility study. (utsouthwestern.edu)
Patients14
- For patients who already have gum disease, there are many treatment options available up to and including surgery. (fortunionfamilydental.com)
- Greenwich, CT, January 28, 2009 - Patient groups voiced concern and disappointment about the new Infectious Diseases Society of America (IDSA) Lyme disease guidelines' panel, which excludes physicians who treat patients with chronic Lyme disease. (lymediseaseassociation.org)
- According to Diane Blanchard, Co-President of Time for Lyme in Connecticut, "Treating physicians must be allowed to make clinical judgments about their patients' conditions due to the complexity of tick-borne diseases, and there are a number of physicians out there nationwide who are knowledgeable enough to recognize the effects of coinfections on diagnosis and treatment. (lymediseaseassociation.org)
- US Congressman Christopher Smith (NJ) co-chair of the House Lyme Disease Caucus, told the patient groups "The Settlement Agreement of the IDSA requires a balanced panel with a variety of experiences, including clinical experience in treating patients with Lyme disease. (lymediseaseassociation.org)
- The groups feel patients should be provided with treatment options, including the use of long term antibiotics, to fight the disease, which has a disability equivalent to that of congestive heart failure. (lymediseaseassociation.org)
- Promote health improvement, wellness, and disease prevention in cooperation with patients, communities, at-risk populations, and other members of an interprofessional team of health care providers. (cdc.gov)
- It included 177 lung cancer patients who also had immune diseases. (survivingmesothelioma.com)
- Patients who are diagnosed with sarcomatoid mesothelioma face a much poorer outlook than those with the more common epithelioid form of the disease. (survivingmesothelioma.com)
- Wasserstein M, Godbold J, McGovern MM. Skeletal manifestations in pediatric and adult patients with Niemann Pick disease type B. J Inherit Metab Dis . (medscape.com)
- Because CINCA and MWS are phenotypic variants on the same clinical spectrum, this suggests that a further large-scale study is desired to investigate the association between degree of monocytic cell death and disease severity in CAPS patients. (bvsalud.org)
- We performed brain magnetic resonance imaging in 14 patients with Kawasaki disease who were treated with infliximab (IFX) at 56 months of age (32-62 months of age) and 23 months (5-35 months) after IFX therapy. (bvsalud.org)
- New treatments and cures are needed to reduce the impact of neurological diseases on patients and the huge burden they place on healthcare systems. (labiotech.eu)
- There is a rumor that a Sars-CoV-2 infection causes definitely not the common cold," adds Martin Witzenrath from the clinic for infectiology and pneumology at the Charité hospital in Berlin, where, according to his information, currently, more than 20 patients with different severe forms of the disease to be treated. (vaccar.biz)
- The distinction between Raynaud disease and Raynaud phenomenon is arbitrary and is best made by dividing patients into those with normal digital arteries (Raynaud disease) and those with obstructed arteries (Raynaud phenomenon). (medscape.com)
19972
- In 1997, he became chief of the branch's Surveillance Section, and in 2006, after a reorganization of CDC, he became chief of the Surveillance and Diagnosis Branch within the newly formed Influenza Division, National Center for Immunization and Respiratory Diseases. (cdc.gov)
- rate from this cause was 2.7 per 100,000 standard population, the Annually, an estimated $80 to $100 billion dollars are spent on health same as in the previous year (figure 1 and table A). Preliminary data care expenses or lost in wages for the persons with Alzheimer's for 1997 indicate that the age-adjusted rate remained at the same disease or their care givers. (cdc.gov)
Search1
- Results of search for 'ccl=au:'Cairncross, Sandy. (who.int)
Preventable4
- To describe the epidemiology of selected vaccine-preventable diseases in NSW for 2013. (who.int)
- Vaccine preventable diseases were relatively well controlled in NSW in 2013, with declining or stable notification rates in most diseases compared with the previous year. (who.int)
- Tooth Decay - A Preventable Disease Tooth decay is the number one reason children and adults lose teeth during their lifetime. (watertowndds.com)
- Whether diseases start at home or abroad, are curable or preventable, chronic or acute, or from human activity or deliberate attack, CDC responds to America's most pressing health threats. (cdc.gov)
Diagnosis and treatment3
- Because gum disease is the number one cause of tooth loss and occurs in nearly half of all adults, periodontal treatment often involves diagnosis and treatment of the disease. (fortunionfamilydental.com)
- The rich risk factor, environmental and health data as well as the genome- and methylome-wide data is used in studies ranging from assessing the role of physical activity, sleep, and transportation noise in cardio-metabolic disease etiology to the evaluation of chronic disease diagnosis and treatment. (swisstph.ch)
- Grabowski GA. Phenotype, diagnosis, and treatment of Gaucher's disease. (medscape.com)
Neurological6
- Neurodegenerative diseases are incurable and devastating neurological disorders characterized by the progressive loss of the structure and function of neurons in the central nervous system or peripheral nervous system. (mdpi.com)
- Can Better Disease Modeling Help Fight Neurological Diseases? (labiotech.eu)
- Neurological diseases range from Alzheimer's and other dementias to stroke and brain cancer . (labiotech.eu)
- Many models for neurological diseases are available to researchers. (labiotech.eu)
- However, current approaches to modeling neurological diseases have limitations, which can undermine research efforts. (labiotech.eu)
- Many neurological diseases affect multiple regions of the brain and many cell types. (labiotech.eu)
Sexually transmit2
Immunology1
- Day 1 will provide a survey of current ontology-based research in immunology and infectious disease with a view to future coordination among ontology developers and users in this field. (bioontology.org)
Clinical5
- Graff-Radford J, Schwartz K, Gavrilova RH, Lachance DH, Kumar N. Neuroimaging and clinical features in type II (late-onset) Alexander disease. (medlineplus.gov)
- Their comparative small effect sizes and long latency periods from molecular damage to the envolvement of clinical disease complicate causal disease understanding. (swisstph.ch)
- The aim of this study is to investigate the alterations of the epidemiology and clinical characteristics of RVGE-associated convulsion after the introduction of RV vaccines and evaluate the reduction of the disease in the context of the vaccination rate. (bvsalud.org)
- Globally, caries disease still affects from 60% to 90% of scholars and most of the adults with different severities of the clinical sequela 30 . (bvsalud.org)
- The findings of our studies, along with clinical findings reported by other groups, indicate the usefulness of daily use of curcumin supplement for the prevention and treatment of several diseases. (naturalsociety.com)
Chronic diseases7
- To improve the public health system's ability to prevent and control chronic diseases, we must first understand current practice and develop appropriate strategies for measuring performance. (cdc.gov)
- Less visible public health challenges are the epidemics in chronic diseases, such as obesity and diabetes (9). (cdc.gov)
- Chronic diseases cause 70% of deaths in the United States and affect 90 million people (10). (cdc.gov)
- Yet chronic disease prevention and control in public health practice have been neglected, probably because of the historical roots of public health in addressing acute, infectious illnesses, the mechanisms of public health funding, and the possible perception that chronic diseases are not amenable to public health action (11). (cdc.gov)
- Among the chronic diseases, diabetes is an optimal choice for studying the performance of governmental public health agencies in chronic disease prevention and control. (cdc.gov)
- Chronic diseases are caused by a complex network of these factors, which damage molecules and modify biological pathways. (swisstph.ch)
- The fact that chronic diseases are the main causes of disability (5,16) makes chronic disease-free life expectancy one of the principal indicators of healthy life expectancy. (who.int)
Infectious disease3
- This fieldwork experience was the capstone of my minor as it was the culmination of many different courses I took before going abroad such as introduction to global health, epidemiology, ecology of infectious disease, etc. (psu.edu)
- The National Center for Biomedical Ontology (NCBO) in collaboration with the Protein Ontology (PRO) and the Infectious Disease Ontology (IDO) will host a three-day dissemination workshop in Buffalo, NY on June 11-13, 2012. (bioontology.org)
- Day 3 will include a session devoted to the use of ontologies to assist clinicians working with infectious disease data, followed by a session on the Ontology for General Medical Science. (bioontology.org)
Alexander's Disease2
Astrocytes2
- Our understanding of the normative biology of astrocytes has been aided by the development of animal models in which astrocyte-specific proteins and pathways have been manipulated, and mouse models of neurodegenerative diseases have also revealed astrocyte-specific pathologies that contribute to neurodegeneration. (nature.com)
- If a particular type of neuron, or astrocytes, or microglia cannot be produced, then the disease cannot be studied. (labiotech.eu)
Autosomal dominant2
- Alexander disease (AD) is a rare, progressive, autosomal dominant leukodystrophy affecting the central nervous system (CNS) white matter with frontal lobe preponderance. (nijp.org)
- Muckle-Wells syndrome (MWS) is an autosomal dominant autoinflammatory disease recognized as the intermediate phenotype of cryopyrin-associated periodic syndrome (CAPS) caused by NLRP3 gene mutation. (bvsalud.org)
Mutations2
- Mutations in the GFAP gene cause Alexander disease. (medlineplus.gov)
- De novo mutations in the GFAP gene are associated with the disease with propensity for paternal inheritance. (bvsalud.org)
Genetics2
- Swiss TPH is participating to ALEC with the SAPALDIA cohort and is leading the work package on genetics and epigenetics. (swisstph.ch)
- Delineating the role of alterations in lipid metabolism to the pathogenesis of inherited skeletal and cardiac muscle disorders: Thematic Review Series: Genetics of Human Lipid Diseases. (medscape.com)
Langmuir1
- On April 26, Donald Warne, MD, MPH, acclaimed physician and scholar in Indigenous health, health education, policy, and equity will deliver this year's Alexander D. Langmuir lecture , Engaging Indigenous Communities to Promote Health Equity . (cdc.gov)
Upper extremity3
- Venal thrombosis can be portal, renal, hepatic, Paget-Schrotter disease (upper extremity) and Thoracic outlet syndrome (unrelated to trauma). (researchgate.net)
- Arterial occlusive disease of the upper extremity may represent either local or systemic disease. (medscape.com)
- Symptomatic upper-extremity arterial occlusive disease is uncommon because of the abundant collateral network and the infrequency of atherosclerosis in the upper extremity. (medscape.com)
Etiology2
- Alexander disease (AD) is a rare, lethal leukodystrophy of the central nervous system of unknown etiology. (nijp.org)
- The pattern of arterial disease varies according to etiology. (medscape.com)
Adults3
- The Swiss study on Air Pollution And Lung Disease in Adults (SAPALDIA) is the only Swiss-wide chronic disease cohort with associated biobank. (swisstph.ch)
- He has had many cases of interstitial keratitis in adults, in which the complete opacity of the cornea has become absolutely clear in from three to five months, and anyone who has had much experience of this disease in adults knows how often permanent impairment of sight results, and how long the treatment used to last, especially if irritants had been used prior to colloidal treatment. (wishgranted.com)
- Probably not, but reports claim that eventual reduction in adults' edentulism may indicate the decrease in the disease severity, that is, deep pockets 29 . (bvsalud.org)
Onset3
- We report a case of 8 year old child with onset of disease at the age of 9 months with global developmental delay, macrocephaly, seizures along with psychomotor retardation & spasticity, who is currently on symptomatic treatment. (nijp.org)
- Immunoglobulin heavy and light chain gene features are correlated with primary cold agglutinin disease onset and activity. (medscape.com)
- Morbidity expansion (9) refers to an increase in unhealthy years as a proportion of life expectancy, which extends the longevity of people with a chronic disease without postponing the onset age (10). (who.int)
Developmental disabilities1
- Advancing knowledge of human development, developmental disabilities, and neurodegenerative diseases. (wisc.edu)
19961
- At later stages of the disease, persons level as 1996 (3). (cdc.gov)
Gingivitis2
- The earliest stage of the disease is gingivitis, which is reversible if treated. (wordpress.com)
- Some bacteria can also cause gingivitis and other gum diseases. (watertowndds.com)
GFAP1
- Quinlan RA, Brenner M, Goldman JE, Messing A. GFAP and its role in Alexander disease. (medlineplus.gov)
Soybean3
- Over the last several weeks we have started seeing seedling diseases in soybean. (unl.edu)
- Additional information on Phytophthora and Rhizoctonia diseases of soybean can be found on the Plant Disease Central website. (unl.edu)
- For instance, it is the most important soybean disease in Kansas. (soybeanresearchinfo.com)
Progression4
- Often we hear anecdotes of "well, endometriosis was there, that's not why the patient came in" but as we move towards the other end of the spectrum we can start to recognize and appreciate highly invasive disease, and even, perhaps, a progression towards malignancy. (endofound.org)
- Currently, there are no neuroprotective agents available that can effectively slow the disease progression. (springer.com)
- Diapocynin also halted the disease progression in a chronic mouse model of PD. (springer.com)
- Modeling the time-series of high-dimensional, longitudinal data is important for predicting patient disease progression. (mit.edu)
Atlanta2
- Women who suffer from sleep apnea in Atlanta and elsewhere may have an increased risk for heart disease. (atlantaent.com)
- Atlanta, GA: Agency for Toxic Substances and Disease Registry. (cdc.gov)
Abnormalities1
- Common problems in juvenile and adult forms of Alexander disease include speech abnormalities, swallowing difficulties, seizures, and poor coordination (ataxia). (medlineplus.gov)
Infection5
- The national Lyme Disease Association, (LymeDiseaseAssociation.org), the California Lyme Disease Association (lymedisease.org), and Time for Lyme (timeforlyme.org) are non-profit organizations that were founded by individuals who had personal experience with Lyme disease, in order to address the lack of education and support services available for this newly emerging infection. (lymediseaseassociation.org)
- The nonpolio viruses (group A and B coxsackieviruses, echoviruses, enteroviruses) are responsible for a wide spectrum of diseases in persons of all ages, although infection and illness occur most commonly in infants. (medscape.com)
- Alexander Gordon, puerperal sepsis, and modern theories of infection control - Semmelweis in perspective. (bvsalud.org)
- Stress caused by high plant populations, soil compaction, improperly applied herbicides, nematodes, or other diseases can favor the charcoal rot pathogen and increase the risk of infection. (soybeanresearchinfo.com)
- 2]. It may arise as a result of infection by any of more than 20 pathogens, and so should be thought of as a group of diseases. (pharmiweb.com)
Pediatrics2
- Pediatrics Central , peds.unboundmedicine.com/pedscentral/view/5-Minute-Pediatric-Consult/617875/all/Alexander_disease. (unboundmedicine.com)
- I'm Dr Alexander Egbe, assistant professor of medicine and pediatrics at Mayo Clinic. (medscape.com)
Cohort1
- Disease characteristics of MCT8 deficiency: an international, retrospective, multicentre cohort study. (nih.gov)
Prevention and treatment1
- If gum disease is diagnosed, we offer in-house treatment or referral to a periodontist, which is a dentist who specializes in the diagnosis, prevention and treatment of periodontal diseases. (wordpress.com)
Health8
- Guidelines for the safe use of wastewater and excreta in agriculture and aquaculture : measures for public health protection / prepared by Duncan Mara & Sandy Cairncross. (who.int)
- Exposomics) and respiratory health research (ALEC). (swisstph.ch)
- Dr. Alexander Papanastassiou is an assistant professor in the Department of Neurosurgery at UT Health San Antonio. (uthscsa.edu)
- No official estimates have been published regarding healthy life expectancy in Algeria, and chronic disease-free life expectancy in particular, despite their importance for assessing public health policy effectiveness and predicting social security expenditure. (who.int)
- We will start with quotes from the book "Colloids in Health and Disease" by Alfred B. Searle, published in 1920. (wishgranted.com)
- Preventive Medicine is a global intellectual journal that encourages prompt publication of original articles on the science and practice of disease hindrance, health promotion, and public health policymaking. (imedpub.com)
- Preventive Medicine's final goal is to publish research work that may have an impression on the work of practitioners of disease hindrance and health promotion, furthermore as of connected disciplines. (imedpub.com)
- This information should not be used for diagnosing or treating a health problem or disease or prescribing any medication. (footfixer.net)
20181
- July, 2017) [Online] Available at: https://www.parkinsons.org.uk/professionals/resources/nice-guideline-ng71-parkinsons-disease adults#:~:text=This%20guideline%20covers%20diagnosing%20and,people%20aged%2018%20and%20over. (stmjournals.in)
Familial1
- Does genetic anticipation occur in familial Alexander disease? (kcl.ac.uk)
Research7
- The biggest problem with Dr. Tarr's research is that she bases her methods on that psychopath (when he learned he had AIDS, he felt no compunction to inform his partners of his deadly and transmissable disease) Michel Foucault . (lukeford.net)
- We know, from the research of Joren Staring (1) and from Articles and Lectures (2) that Alexander was exposed to several outside influences, including the Delsarte system of speech, gesture and movement. (lukeford.net)
- Our mission is to prevent and cure disease through biomedical research. (coriell.org)
- Together with Keith Isaacson , Linda and Keith came together to found in 2009, now some of you know, the MIT Center for Gynopathology Research, which was motivated out of a recognition for the need for greater focus on the basic biological and engineering sciences for developing innovative strategies to cell molecular research for such a complex disease. (endofound.org)
- The depth of knowledge gained since then is impressive, with research having addressed significant aspects of the disease and the devils responses to it. (edu.au)
- Peerschke EIB, Agrawal Y, Alexander CB, Bovill E, Laposata M. Proposed research training guidelines for residents in laboratory medicine. (uab.edu)
- This bracelet supports Heart Disease Care & Research promoting initiatives that focus on creating a world of longer & healthier lives. (greenboutiquefl.com)