Alexander Disease: Rare leukoencephalopathy with infantile-onset accumulation of Rosenthal fibers in the subpial, periventricular, and subependymal zones of the brain. Rosenthal fibers are GLIAL FIBRILLARY ACIDIC PROTEIN aggregates found in ASTROCYTES. Juvenile- and adult-onset types show progressive atrophy of the lower brainstem instead. De novo mutations in the GFAP gene are associated with the disease with propensity for paternal inheritance.Glial Fibrillary Acidic Protein: An intermediate filament protein found only in glial cells or cells of glial origin. MW 51,000.alpha-Crystallin B Chain: One of the alpha crystallin subunits. In addition to being expressed in the lens (LENS, CRYSTALLINE), alpha-crystallin B chain has been found in a variety of tissues such as HEART; BRAIN; MUSCLE; and KIDNEY. Accumulation of the protein in the brain is associated with NEURODEGENERATIVE DISEASES such as CREUTZFELDT-JAKOB SYNDROME and ALEXANDER DISEASE.Astrocytes: A class of large neuroglial (macroglial) cells in the central nervous system - the largest and most numerous neuroglial cells in the brain and spinal cord. Astrocytes (from "star" cells) are irregularly shaped with many long processes, including those with "end feet" which form the glial (limiting) membrane and directly and indirectly contribute to the BLOOD-BRAIN BARRIER. They regulate the extracellular ionic and chemical environment, and "reactive astrocytes" (along with MICROGLIA) respond to injury.Brain Diseases: Pathologic conditions affecting the BRAIN, which is composed of the intracranial components of the CENTRAL NERVOUS SYSTEM. This includes (but is not limited to) the CEREBRAL CORTEX; intracranial white matter; BASAL GANGLIA; THALAMUS; HYPOTHALAMUS; BRAIN STEM; and CEREBELLUM.Age of Onset: The age, developmental stage, or period of life at which a disease or the initial symptoms or manifestations of a disease appear in an individual.Brain: The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.Magnetic Resonance Imaging: Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.Mutation: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.Pseudotumor Cerebri: A condition marked by raised intracranial pressure and characterized clinically by HEADACHES; NAUSEA; PAPILLEDEMA, peripheral constriction of the visual fields, transient visual obscurations, and pulsatile TINNITUS. OBESITY is frequently associated with this condition, which primarily affects women between 20 and 44 years of age. Chronic PAPILLEDEMA may lead to optic nerve injury (see OPTIC NERVE DISEASES) and visual loss (see BLINDNESS).Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)Intracranial Hypertension: Increased pressure within the cranial vault. This may result from several conditions, including HYDROCEPHALUS; BRAIN EDEMA; intracranial masses; severe systemic HYPERTENSION; PSEUDOTUMOR CEREBRI; and other disorders.Infectious Disease Medicine: A branch of internal medicine concerned with the diagnosis and treatment of INFECTIOUS DISEASES.Candidiasis, Invasive: An important nosocomial fungal infection with species of the genus CANDIDA, most frequently CANDIDA ALBICANS. Invasive candidiasis occurs when candidiasis goes beyond a superficial infection and manifests as CANDIDEMIA, deep tissue infection, or disseminated disease with deep organ involvement.Communicable DiseasesCardiovascular Diseases: Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.Physicians: Individuals licensed to practice medicine.Famous PersonsLakes: Inland bodies of still or slowly moving FRESH WATER or salt water, larger than a pond, and supplied by RIVERS and streams.Meningoencephalitis: An inflammatory process involving the brain (ENCEPHALITIS) and meninges (MENINGITIS), most often produced by pathogenic organisms which invade the central nervous system, and occasionally by toxins, autoimmune disorders, and other conditions.Oligoclonal Bands: Multiple protein bands serving as markers of specific ANTIBODIES and detected by ELECTROPHORESIS of CEREBROSPINAL FLUID or serum. The bands are most often seen during inflammatory or immune processes and are found in most patients with MULTIPLE SCLEROSIS.Arthritis, Rheumatoid: A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.Lymphocytosis: Excess of normal lymphocytes in the blood or in any effusion.Enzootic Bovine Leukosis: A lymphoid neoplastic disease in cattle caused by the bovine leukemia virus. Enzootic bovine leukosis may take the form of lymphosarcoma, malignant lymphoma, or leukemia but the presence of malignant cells in the blood is not a consistent finding.Laboratory Infection: Accidentally acquired infection in laboratory workers.Skin DiseasesPrognosis: A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.Bacteriology: The study of the structure, growth, function, genetics, and reproduction of bacteria, and BACTERIAL INFECTIONS.Anatomy: A branch of biology dealing with the structure of organisms.GermanyCyclonic Storms: Non-frontal low-pressure systems over tropical or sub-tropical waters with organized convection and definite pattern of surface wind circulation.BerlinDisasters: Calamities producing great damage, loss of life, and distress. They include results of natural phenomena and man-made phenomena. Normal conditions of existence are disrupted and the level of impact exceeds the capacity of the hazard-affected community.New Orleans: City in Orleans Parish (county), largest city in state of LOUISIANA. It is located between the Mississippi River and Lake Pontchartrain.LouisianaRelief Work: Assistance, such as money, food, or shelter, given to the needy, aged, or victims of disaster. It is usually granted on a temporary basis. (From The American Heritage Dictionary, 2d college ed)Ecosystem: A functional system which includes the organisms of a natural community together with their environment. (McGraw Hill Dictionary of Scientific and Technical Terms, 4th ed)Penstemon: A plant genus of the family Plantaginaceae. Members contain phenylpropanoid and iridoid glycosides.Birds: Warm-blooded VERTEBRATES possessing FEATHERS and belonging to the class Aves.Soil: The unconsolidated mineral or organic matter on the surface of the earth that serves as a natural medium for the growth of land plants.Perfume: A substance, extract, or preparation for diffusing or imparting an agreeable or attractive smell, especially a fluid containing fragrant natural oils extracted from flowers, woods, etc., or similar synthetic oils. (Random House Unabridged Dictionary, 2d ed)Crocus: A plant genus, in the IRIDACEAE family, known as a source of Saffron.Mountaineering: A sport involving mountain climbing techniques.Scent Glands: Exocrine glands in animals which secrete scents which either repel or attract other animals, e.g. perianal glands of skunks, anal glands of weasels, musk glands of foxes, ventral glands of wood rats, and dorsal glands of peccaries.Anthropology, Physical: The comparative science dealing with the physical characteristics of humans as related to their origin, evolution, and development in the total environment.Soil Microbiology: The presence of bacteria, viruses, and fungi in the soil. This term is not restricted to pathogenic organisms.Firearms: Small-arms weapons, including handguns, pistols, revolvers, rifles, shotguns, etc.Wounds, Gunshot: Disruption of structural continuity of the body as a result of the discharge of firearms.Racism: Differential treatment or unequal access to opportunities, based on group membership such as origin or ethnicity.Congo: A republic in central Africa lying between GABON and DEMOCRATIC REPUBLIC OF THE CONGO and south of Cameroon. Its capital is Brazzaville.Violence: Individual or group aggressive behavior which is socially non-acceptable, turbulent, and often destructive. It is precipitated by frustrations, hostility, prejudices, etc.Congo Red: An acid dye used in testing for hydrochloric acid in gastric contents. It is also used histologically to test for AMYLOIDOSIS.Democratic Republic of the Congo: A republic in central Africa, east of the REPUBLIC OF THE CONGO, south of the CENTRAL AFRICAN REPUBLIC and north of ANGOLA and ZAMBIA. The capital is Kinshasa.

The clinicopathological spectrum of Rosenthal fibre encephalopathy and Alexander's disease: a case report and review of the literature. (1/47)

Alexander's disease is a leucodystrophy that usually presents in early childhood, but can infrequently arise in adults. It is characterised pathologically by megalencephaly, demyelination, and the presence of numerous Rosenthal fibres. Most cases have been shown to be due to mutations in the gene encoding glial fibrillary acidic protein. In rare instances, numerous Rosenthal fibres have been found at autopsy in patients who have suffered protracted debilitating systemic illnesses, some with associated brain stem signs, and in very rare instances in patients with no apparent neurological abnormality. The term "Rosenthal fibre encephalopathy" is used to distinguish these cases from those of Alexander's disease. We report the first case of Rosenthal fibre encephalopathy in a young man with AIDS, and review the literature.  (+info)

Alexander-disease mutation of GFAP causes filament disorganization and decreased solubility of GFAP. (2/47)

Alexander disease is a fatal neurological illness characterized by white-matter degeneration and the formation of astrocytic cytoplasmic inclusions called Rosenthal fibers, which contain the intermediate filament glial fibrillary acidic protein (GFAP), the small heat-shock proteins HSP27 and alphaB-crystallin, and ubiquitin. Many Alexander-disease patients are heterozygous for one of a set of point mutations in the GFAP gene, all of which result in amino acid substitutions. The biological effects of the most common alteration, R239C, were tested by expressing the mutated protein in cultured cells by transient transfection. In primary rat astrocytes and Cos-7 cells, the mutant GFAP was incorporated into filament networks along with the endogenous GFAP and vimentin, respectively. In SW13Vim(-) cells, which have no endogenous cytoplasmic intermediate filaments, wild-type human GFAP frequently formed filamentous bundles, whereas the R239C GFAP formed 'diffuse' and irregular patterns. Filamentous bundles of R239C GFAP were sometimes formed in SW13Vim(-) cells when wild-type GFAP was co-transfected. Although the presence of a suitable coassembly partner (vimentin or GFAP) reduced the potential negative effects of the R239C mutation on GFAP network formation, the mutation affected the stability of GFAP in cells in a dominant fashion. Extraction of transfected SW13Vim(-) cells with Triton-X-100-containing buffers showed that the mutant GFAP was more resistant to solubilization at elevated KCl concentrations. Both wild-type and R239C GFAP assembled into 10 nm filaments with similar morphology in vitro. Thus, although the R239C mutation does not appear to affect filament formation per se, the mutation alters the normal solubility and organization of GFAP networks.  (+info)

Gene expression analysis in mice with elevated glial fibrillary acidic protein and Rosenthal fibers reveals a stress response followed by glial activation and neuronal dysfunction. (3/47)

Alexander disease is a fatal neurodegenerative disorder resulting from missense mutations of the intermediate filament protein, GFAP. The pathological hallmark of this disease is the formation of cytoplasmic protein aggregates within astrocytes known as Rosenthal fibers. Transgenic mice engineered to over-express wild-type human GFAP develop an encephalopathy with identical aggregates, suggesting that elevated levels of GFAP in addition to mutant protein contribute to the pathogenesis of this disorder. To study further the effects of elevated GFAP and Rosenthal fibers per se, independent of mutations, we performed gene expression analysis on olfactory bulbs of transgenic mice at two different ages to follow the progression of pathology. The expression profiles reveal a stress response that includes genes involved in glutathione metabolism, peroxide detoxification and iron homeostasis. Many of these genes are regulated by the transcription factor Nfe2l2, which is also increased in expression at 3 weeks. An immune-related response occurs with activation of cytokine and cytokine receptor genes, complement components and acute phase response genes. These transcripts are further elevated with age, with additional induction of macrophage-specific markers such as Mac1 and CD68, suggesting activation of microglia. At 4 months, decreased expression of genes for microtubule-associated proteins, vesicular trafficking proteins and neurotransmitter receptors becomes apparent. Interneuron-specific transcription factors including Dlx family members and Pax6 are downregulated as well as Gad1 and Gad2, suggesting impairment of GABAergic granule cells. Together, these data implicate an initial stress response by astrocytes, which results in the activation of microglia and compromised neuronal function.  (+info)

Plectin regulates the organization of glial fibrillary acidic protein in Alexander disease. (4/47)

Alexander disease (AxD) is a rare but fatal neurological disorder caused by mutations in the astrocyte-specific intermediate filament protein glial fibrillary acidic protein (GFAP). Histologically, AxD is characterized by cytoplasmic inclusion bodies called Rosenthal fibers (RFs), which contain GFAP, small heat shock proteins, and other undefined components. Here, we describe the expression of the cytoskeletal linker protein plectin in the AxD brain. RFs displayed positive immunostaining for plectin and GFAP, both of which were increased in the AxD brain. Co-localization, co-immunoprecipitation, and in vitro overlay analyses demonstrated direct interaction of plectin and GFAP. GFAP with the most common AxD mutation, R239C (RC GFAP), mainly formed abnormal aggregates in human primary astrocytes and murine plectin-deficient fibroblasts. Transient transfection of full-length plectin cDNA converted these aggregates to thin filaments, which exhibited diffuse cytoplasmic distribution. Compared to wild-type GFAP expression, RC GFAP expression lowered plectin levels in astrocytoma-derived stable transfectants and plectin-positive fibroblasts. A much higher proportion of total GFAP was found in the Triton X-insoluble fraction of plectin-deficient fibroblasts than in wild-type fibroblasts. Taken together, our results suggest that insufficient amounts of plectin, due to RC GFAP expression, promote GFAP aggregation and RF formation in AxD.  (+info)

Neuropathology for the neuroradiologist: Rosenthal fibers. (5/47)

Distinctive intracellular structures known as inclusions may be occasionally observed on stained tissue preparations and may further suggest a specific diagnosis. Pathologists rely on these findings much as radiologists rely on findings revealed in the gray-scale patterns of densities and intensities on images. Appreciation of these inclusions can enhance the interactions of the neuroradiologist with the neuropathologist and deepen understanding of certain conditions. This report reviews the neuropathologically observed intracellular inclusions known as Rosenthal fibers in the context of Alexander disease and slow-growing tumors such as pilocytic astrocytoma.  (+info)

The Alexander disease-causing glial fibrillary acidic protein mutant, R416W, accumulates into Rosenthal fibers by a pathway that involves filament aggregation and the association of alpha B-crystallin and HSP27. (6/47)

Here, we describe the early events in the disease pathogenesis of Alexander disease. This is a rare and usually fatal neurodegenerative disorder whose pathological hallmark is the abundance of protein aggregates in astrocytes. These aggregates, termed "Rosenthal fibers," contain the protein chaperones alpha B-crystallin and HSP27 as well as glial fibrillary acidic protein (GFAP), an intermediate filament (IF) protein found almost exclusively in astrocytes. Heterozygous, missense GFAP mutations that usually arise spontaneously during spermatogenesis have recently been found in the majority of patients with Alexander disease. In this study, we show that one of the more frequently observed mutations, R416W, significantly perturbs in vitro filament assembly. The filamentous structures formed resemble assembly intermediates but aggregate more strongly. Consistent with the heterozygosity of the mutation, this effect is dominant over wild-type GFAP in coassembly experiments. Transient transfection studies demonstrate that R416W GFAP induces the formation of GFAP-containing cytoplasmic aggregates in a wide range of different cell types, including astrocytes. The aggregates have several important features in common with Rosenthal fibers, including the association of alpha B-crystallin and HSP27. This association occurs simultaneously with the formation of protein aggregates containing R416W GFAP and is also specific, since HSP70 does not partition with them. Monoclonal antibodies specific for R416W GFAP reveal, for the first time for any IF-based disease, the presence of the mutant protein in the characteristic histopathological feature of the disease, namely Rosenthal fibers. Collectively, these data confirm that the effects of the R416W GFAP are dominant, changing the assembly process in a way that encourages aberrant filament-filament interactions that then lead to protein aggregation and chaperone sequestration as early events in Alexander disease.  (+info)

Synergistic effects of the SAPK/JNK and the proteasome pathway on glial fibrillary acidic protein (GFAP) accumulation in Alexander disease. (7/47)

Protein aggregates in astrocytes that contain glial fibrillary acidic protein (GFAP), small heat shock proteins, and ubiquitinated proteins are termed Rosenthal fibers and characterize Alexander disease, a leukodystrophy caused by heterozygous mutations in GFAP. The mechanisms responsible for the massive accumulation of GFAP in Alexander disease remain unclear. In this study, we show that overexpression of both wild type and R239C mutant human GFAP led to cytoplasmic inclusions. GFAP accumulation also led to a decrease of proteasome activity and an activation of the MLK2-JNK pathway. In turn, the expression of activated mixed lineage kinases (MLKs) induced JNK activation and increased GFAP accumulation, whereas blocking the JNK pathway decreased GFAP accumulation. Activated MLK also inhibited proteasome function. A direct inhibition of proteasome function pharmacologically further activated JNK. Our data suggest a synergistic interplay between the proteasome and the SAPK/JNK pathway in the context of GFAP accumulation. Feedback interactions among GFAP accumulation, SAPK/JNK activation, and proteasomal hypofunction cooperate to produce further protein accumulation and cellular stress responses.  (+info)

A case of infantile Alexander disease accompanied by infantile spasms diagnosed by DNA analysis. (8/47)

Alexander disease (AD) is a rare leukodystrophy of the central nervous system of unknown etiology. AD is characterized by progressive failure of central myelination and the accumulation of Rosenthal fibers in astrocytes, and is inevitably lethal in nature. Symptomatically, AD is associated with leukoencephalopathy with macrocephaly, seizures, and psychomotor retardation in infants, and usually leads to death within the first decade. Its characteristic magnetic resonance imaging (MRI) findings have been described as demyelination predominantly in the frontal lobe. Moreover, dominant mutations in the GFAP gene, coding for glial fibrillary acidic protein (GFAP), a principal astrocytic intermediate filament protein, have been shown to lead to AD. The disease can now be detected by genetic diagnosis. We report the Korean case of an 8-month-old male patient with AD. He was clinically characterized due to the presence of psychomotor retardation, megalencephaly, spasticity, and recurrent seizures including infantile spasms which is a remarkable presentation. Demyelination in the frontal lobe and in a portion of the temporal lobe was demonstrated by brain MRI. Moreover, DNA analysis of peripheral blood showed the presence of a R239L mutation in the GFAP gene, involving the replacement of guanine with thymine.  (+info)

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BACKGROUND: We studied a family including two half-siblings, sharing the same mother, affected by slowly progressive, adult-onset neurological syndromes. In spite of the diversity of the clinical features, characterized by a mild movement disorder with cognitive impairment in the elder patient, and severe motor-neuron disease (MND) in her half-brother, the brain Magnetic Resonance Imaging (MRI) features were compatible with adult-onset Alexanders disease (AOAD), suggesting different expression of the same, genetically determined, condition.METHODS: Since mutations in the alpha isoform of glial fibrillary acidic protein, GFAP-α, the only cause so far known of AOAD, were excluded, we applied exome Next Generation Sequencing (NGS) to identify gene variants, which were then functionally validated by molecular characterization of recombinant and patient-derived cells.RESULTS: Exome-NGS revealed a mutation in a previously neglected GFAP isoform, GFAP-ϵ, which disrupts the GFAP-associated ...
Alexander disease is a rare disorder resulting from a glial fibrillary acidic protein gene mutation which causes progressive degeneration of white matter. With the usual poor prognosis, there are few case reports with long-term follow-up. We report the five-year clinical course of Alexander disease in one case using serial magnetic resonance imaging. A 12-month-old Japanese male was referred to the pediatrics department in our hospital because of developmental retardation. Alexander disease was diagnosed by gene examination of the mutation of a glial fibrillary acidic protein. Magnetic resonance imaging findings showed abnormalities in white matter, deep gray matter, and medulla oblongata. Serial magnetic resonance imaging examinations until the age of five were performed and changes in magnetic resonance imaging findings were compared to the progression in clinical symptoms. Alexander disease is a very rare disease with a variety of clinical phenotypes. Therefore serial magnetic resonance imaging
Alexander disease, also known as fibrinoid leukodystrophy, is a progressive and fatal neurodegenerative disease. It is a rare genetic disorder and mostly affects infants and children, causing developmental delay and changes in physical characteristics. Delays in development of some physical, psychological and behavioral skills; progressive enlargement of the head (macrocephaly), seizures, spasticity, and in some cases also hydrocephalus, idiopathic intracranial hypertension, and dementia. Alexander disease is a genetic disorder affecting the midbrain and cerebellum of the central nervous system. It is caused by mutations in the gene for glial fibrillary acidic protein (GFAP) that maps to chromosome 17q21. It is inherited in an autosomal dominant manner, such that the child of a parent with the disease has a 50% chance of inheriting the condition, if the parent is heterozygotic. However, most cases arise de novo as the result of sporadic mutations. Alexander disease belongs to leukodystrophies, a ...
Alexander disease is a leukodystrophy, a group of more than 15 rare genetic disorders that cause progressive degeneration of the white matter of the brain due…
Alexander disease Labrador retriever type (Leukodystrophy) is a rare neurodegenerative disorder characterized by astrocyte dysfunction.
Palatal tremor is essential (EPT), where isolated, or symptomatic (SPT), where part of a symptom complex. SPT is reported with lesions in the dentato-rubro-olivary pathway and in neurodegenerative and genetic disorders. Some patients have the poorly understood progressive ataxia and palatal tremor (PAPT).. We report a series of twelve patients with SPT. Two have been diagnosed with multi-system atrophy without pathological confirmation. Two have vascular disease affecting the dentato-rubro-olivary pathway. One has mutation-proven Alexander Disease. The remaining seven are all male and classified as sporadic PAPT.. The age range at symptom onset is 36-87 years (36-80 in the PAPT group). All twelve have ataxia. Of the PAPT group, five of seven (71%) have dysarthria. Two PAPT patients had normal DAT scans, and two tested negative for POLG1 and Alexander Disease. Eleven of the twelve (except the Alexander Disease patient) had bilateral olivary hypertrophy on brain MRI.. Palatal tremor is often ...
TY - JOUR. T1 - αB-crystallin and 27-kd heat shock protein are regulated by stress conditions in the central nervous system and accumulate in Rosenthal fibers. AU - Iwaki, T.. AU - Iwaki, A.. AU - Tateishi, J.. AU - Sakaki, Y.. AU - Goldman, J. E.. PY - 1993/12/1. Y1 - 1993/12/1. N2 - To understand the significance of the accumulation of αB-crystallin in Rosenthal fibers within astrocytes, the expression and metabolism of αB- crystallin in glioma cell lines were examined under the conditions of heat and oxidative stress, αB-crystallin mRNA was increased after both stresses, and αB-crystallin protein moved from a detergent-soluble form. In addition, Western blotting of Alexanders disease brain homogenates revealed that the 27-kd heat shock protein (HSP27), which is related to αB-crystallin, accumulates along with αB-crystallin. The presence of HSP27 in Rosenthal fibers was directly demonstrated by immunohistochemistry. Our results suggest that astrocytes in Alexanders disease may be ...
Alexander disease, a Leukodystrophy, is a progressive and fatal neurological disorder in which the destruction of white matter in the brain is accompanied by the formation of abnormal deposits known as Rosenthal fibers. Rosenthal fibers are aggregations of protein that occur in astrocytes, one of the so-called "glial" cells of the central nervous system. These aggregates are found occasionally in other disorders, but not with the abundance or particular distribution in the brain that occurs in Alexander disease.. The age of onset is quite variable, ranging from prenatal through the sixth decade. The most common classification divides patients into three categories based on age of onset, infantile (0-2 years), juvenile (2-12 years), and adult (,12 years). More recently, a different classification has been proposed, with only two categories of type I and type II, with the distinction hinging more on distribution of lesions and clinical presentation rather than age of onset (all type I cases being ...
Alexander appeared on every cycle of the television program Americas Next Top Model as the runway coach to the contestants. He was made a judge starting with Cycle 5. As of Cycle 14 of the show, Alexander was replaced as a permanent judge on the panel by Vogue editor at large André Leon Talley.[9] Alexander stayed on as the shows runway coach and has appeared in many of the international versions of the show.[10]. Alexanders nickname "Miss J", or lovingly "Siss J" after the word sister came from Cycle 1 contestant Robin Manning, who often confused Alexander and Jay Manuel and on several occasions referred to Alexander as "Miss J" by accident because of his flamboyant clothing (Alexander often dresses in drag and usually wears a skirt and high heels during runway walking training) and personality. Accordingly, Jay Manuel is referred to as "Mr. Jay", and ANTM contestants often call them "The Jays", "The Two Jays" or "Mr. and Ms. Jay" when they appear together.[11] In 2008, the Jays were cast ...
Alexander disease is a rare, progressive, and generally fatal neurological disorder that results from dominant mutations affecting the coding region of GFAP, the gene encoding glial fibrillary acidic protein, the major intermediate filament protein of astrocytes in the central nervous system. A key step in pathogenesis appears to be the accumulation of GFAP protein within astrocytes to excessive levels. Studies using mouse models indicate that the severity of the phenotype correlates with the level of expression, and suppression of GFAP expression and/or accumulation is one strategy that is being pursued as a potential treatment. With the goal of identifying biomarkers that indirectly reflect the levels of GFAP in brain parenchyma, we have assayed GFAP levels in two body fluids in humans that are readily accessible as biopsy sites - cerebrospinal fluid and blood. We find that GFAP levels are consistently elevated in the CSF of Alexander disease patients, but only occasionally and modestly in ...
A slowly progressive and ultimately fatal brain disorder that most commonly occurs in children. The infantile form of the disease is characterized by megalencephaly (an abnormally large head), seizures, spasticity and developmental retardation.…
The #1 New York Times bestselling account of a neurosurgeons own near-death experience-for readers of 7 Lessons from Heaven. Thousands of people have had near-death experiences, but scientists have argued that they are impossible. Dr. Eben Alexander was one of those scientists. A highly trained neurosurgeon, Alexander knew that NDEs feel real, but are simply fantasies produced by brains under extreme stress.Then, Dr. Alexanders own brain was attacked by a rare illness. The part of the brain that controls thought and emotion-and in essence makes us human-shut down completely. For seven days he lay in a coma. Then, as his doctors considered stopping treatment, Alexanders eyes popped open. He had come back. Alexanders recovery is a medical miracle. But the real miracle of his story lies elsewhere. While his body lay in coma, Alexander journeyed beyond this world and encountered an angelic being who guided him into the deepest realms of super-physical existence. There he met, and spoke with, the Divine
Introduction. Alexander Fleming Antibiotics One sometimes finds what one is not looking for. Sir Alexander Fleming 1. Alexander Fleming biography 2. The discovery of Penicillin 3. Purification to a stable form and industrial scale production 4. How an antibiotic work 5. Antibiotic resistance 1. Alexander Fleming 1881 - 1955 Alexander Fleming was born in a lonely, rural part of Scotland as the seventh of eight siblings and half-siblings, his family worked an 800-acre farm far away from the nearest house. The Fleming children spent much of their time in the streams, valleys, and moors of the countryside. We unconsciously learned a great deal from nature, said Fleming. When their father died, his eldest son took over the running of the farm. Another brother Tom had studied medicine and was opening a practice in London. Soon, inspired by their brother, four Fleming brothers and a sister were living together in London. Alec, as Alexander was called, had moved to London when he was around 14, and ...
Alexander chisel, 4 mm wide, stainless steel, 18 cm. Alexander chisel, 6 mm wide, stainless steel, 18 cm. Alexander chisel, 8 mm wide, stainless steel, 18 cm. Alexander chisel, 10 mm wide, stainless steel, 18 cm. Alexander chisel, 12 mm wide, stainless steel, 18 cm. Alexander chisel, 14 mm wide, stainless steel, 18 cm. ...
The Dodgers have agreed to terms with left-hander Scott Alexander on a one-year, $875K contract to avoid arbitration, reports Bob Nightengale of USA Today (via Twitter). Alexander falls a bit shy of his $1MM projected salary.. The 30-year-old looked like a potential non-tender candidate, perhaps explaining his decision to settle for slightly less than expected. An integral part of the Los Angeles bullpen in 2018, Alexander was limited to just 28 games last season, none after June 5. Alexander suffered a season-ending forearm issue in his throwing arm, which culminated in surgery to relieve nerve irritation in September.. Alexanders time in LA has been a bit of a mixed bag. Over the past two years, hes given the Dodgers 83.1 innings with a 3.67 ERA and mediocre strikeout (18.9%) and walk (9.9%) rates. Alexanders an elite ground-ball specialist, though. His 68.5% ground ball rate the past two seasons trails only Zack Britton among still-active pitchers (minimum 50 innings). The former ...
Understanding that poor posture is something we teach ourselves, its also important to be aware that it can also be unlearned, by incorporating the right techniques.. The Alexander Technique is integral to correcting poor posture and alleviating the physical effects caused by incorrect body alignment. Rather than being defined as a medical practice, Alexander Technique could be described as a body and mind educational training methodology that teaches you how to achieve optimal coordination and alignment for your individual body shape, by rediscovering better postural techniques.. While you may not have heard of this form of postural training before, it was initially introduced by founder Frederick Matthias Alexander in the 1890s. In conjunction with realigning posture, training in Alexander Technique also helps you avoid unnecessary muscular and mental tension.. Alexander Technique is a preferred training methodology to help prevent musicians injuries and has been known to have positive ...
I have just finished reading a book about the life and times of Alexander The Great ("Alexander The Great" by Robin Lane Fox. Published by Penguin Book. ISBN 0-141-02076-8).. I have recently read a number of different books about Alexander but this one, in particular, kept me going throughout. It was interesting and factual without being condescending. This book doesnt try to paint Alexander as either Great or the Devil but as truly a man who set out to exert some degree of revenge but ended up having travelled from the Mediterranean to the Indian Ocean and was, arguably, the first true explorer.. This man not only trod the path of being an explorer but was a conqueror who took with him thousands of followers who also fought battles, disease, distance, hunger, thirst and the geography to travel the miles with him.. Alexander may or may not have been The Great but he was truly remarkable. I am glad to have found and read this book.. ...
Alexander disease (ALXD) is a rare demyelinating disease of the white matter of the brain that is caused by a mutation in the glial fibrillary acidic protein (GFAP) gene. The overexpression of GFAP in astrocytes induces a failure in the developmental growth of the myelin sheath. The neurodegenerative destruction of the myelin sheath of the white matter is accompanied by an accumulation of abnormal deposits of Rosenthal fibers in astrocytes, which is the hallmark of ALXD. The disease can be divided into four groups based on the onset age of the patients: neonatal, infantile, juvenile, or adult. Early-onset disease is more severe, progresses rapidly, and results in a shorter life span than late-onset cases. Magnetic resonance imaging and genetic tests are mostly used for diagnostic purposes. Pathological tests of brain tissue for Rosenthal fibers are definitive diagnostic methods. Therapeutic strategies are being investigated. Ceftriaxone, which is an enhancer of glial glutamate transporter ...
Bergfield, K.L., Hanson, K.D., Chen, K., Teipel, S.J., Hampel, H., Rapoport, S.I., Moeller, J.R., & Alexander, G.E. (2010). Age-related networks of regional covariance in MRI gray matter: Reproducible multivariate patterns in healthy aging. Neuroimage, 49, 1750-9. PMID: 19796692. Alexander, G.E., Bergfield, K.L., Chen, K., Reiman, E.M., Hanson, K.D., Lin, L., Bandy, D., Caselli, R.J., & Moeller, J.R. (2012). Gray matter network associated with risk for Alzheimers disease in young to middle-aged adults. Neurobiology of Aging, 33, 2723-32. PMID: 22405043. Alexander, G.E., Ryan, L., Bowers, D., Foster, T.C., Bizon, J.L., Geldmacher, D.S., & Glisky, E.L. (2012). Characterizing cognitive aging in humans with links to animal models. Frontiers in Aging Neuroscience, 4, 21. PMID: 22988439. Raichlen, D.A., & Alexander G.E. (2014). Exercise, APOE genotype, and the evolution of the human lifespan. Trends in Neurosciences, 37, 247-55. (Article featured on journal cover, May, 2014.) PMID: 24690272. Nguyen, ...
https://twitter.com/#!/CCSVI_Society Dr. Alexander (endothelial biologist) now presenting MS and cerebral endothelial dysfunctionDr. Alexander: endothelium becomes sticky with shear: activates leukocytes into brain parenchyma Dr. Alexander: endothelial cells very sensitive to glycemic (glucose) and oxidative stressDr. Alexander: Interferon beta may have ...
Grace Hazel SHOWERS ALEXANDER - Yavapai County Arizona - Grace H. (Showers) Alexander - Young b. Aug. 13, 1874, Whitneys Point, N. Y. d. Nov. 8, 1934, Prescott, Az. COD: Cerebral Hemorrhage w/o John H. Alexander (m) May 27, 1903, Little Ash Creek, Az. Territory w/o James B. Young d/o Daniel & Phebe (Holt) Showers Note: resided in Az. 50 years
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Alexander, S. and Udayakumar, V. and Gayathri, V. (2012) Catalytic activity of a supported palladium-benzimidazole complex toward alkene hydrogenation. Transition Metal Chemistry, 37 (4). pp. 367-372. ISSN 1572-901X Alexander, S. and Udayakumar, V. and Gayathri, V. (2012) Synthesis and characterisation of a polymer-bound rhodium-benzimidazole complex as catalyst for the hydrogenation of nitroarenes. Transition Metal Chemistry, 37 (1). pp. 1-6. ISSN 1572-901X Udayakumar, V. and Alexander, S. and Gayathri, V. and Shivakumaraiah, . and Viswanathan, B. (2011) Study on the influence of substituents upon the hydrogenation of nitrobenzene using a polymer-supported palladium-imidazole complex catalyst. Reaction Kinetics, Mechanisms and Catalysis, 103 (2). pp. 341-352. ISSN 1878-5204 Alexander, S. and Udayakumar, V. and Nagaraju, N. and Gayathri, V. (2010) Hydrogenation of substituted nitroarenes by a polymer-bound palladium(II) Schiff base catalyst. Transition Metal Chemistry, 35 (2). pp. 247-251. ISSN ...
The use of imagery to teach or learn the Alexander Technique is, to put it mildly, a controversial topic.. The diverse views were on full display in recent exchanges on the Alexander Technique Forum Facebook Page(1) include everything from general disapproval of using images to endorsement in some or many teaching situations.. Some members have also pointed out that a teachers verbal instructions can generate mental images in a students mind, so the distinction between using words while teaching - which has a long history in Alexander Technique teaching - and using images isnt always clear.. Personally, Ive had mixed results with using mental images.. While I was training in England, I had a great many lessons from a remarkable teacher (not connected to my training course) who used the "string pulling your head up" image during lessons.. On the plus side, that image did get me "out of my hips" in a way Id never before experienced, and the teachers on my training course, who knew nothing ...
Genetic genealogy is the new frontier. Our two DNA views are designed to help you use genetic testing to confirm and expand Alexanders genealogy. The DNA Ancestors page shows the specific ancestors from whom Alexander gets his Y chromosome and mitochondrial DNA. Especially helpful for some serious genetic genealogists is the inheritance pattern for Alexanders X chromosome, also shown here. The DNA Descendants page shows exactly who has inherited Alexanders testable DNA. DNA Ancestor Confirmation Aid ...
Bacterial diversity analysis of moderately thermophilic microflora enriched by different energy sources In this study, cultures grown from explants of rabbit rib perichondrium were exposed to exogenously added transforming growth factor-beta 1 at concentrations of 0.1-10 ng/ml of media. Correlations with the Short Form-36 were used to investigate the convergent validity. Antioxidant status in ceftin dogs with idiopathic dilated cardiomyopathy. The pathological hallmark of Alexander disease is the inclusion body, known as Rosenthal fiber, within the cell bodies and processes of astrocytes. Although IL-4, IL-5, IL-10, and IL-13 each regulate distinct aspects of the granulomatous inflammatory response, IL-13 was identified as the primary mediator of liver fibrosis. Acute effect of whole body vibration on postural control in congenitally blind subjects: clarithromycin a preliminary evidence. Heterokaryons have been utilized for complementation and dominance testing of mutations that affect ...
P,A main neurogenic niche in the adult human brain is the subventricular zone (SVZ). Recent data suggest that the progenitors that are born in the human SVZ migrate via the rostral migratory stream (RMS) towards the olfactory bulb (OB), similar to what has been observed in other mammals. A subpopulation of astrocytes in the SVZ specifically expresses an assembly-compromised isoform of the intermediate filament protein glial fibrillary acidic protein (GFAP-delta). To further define the phenotype of these GFAP-delta expressing cells and to determine whether these cells are present throughout the human subventricular neurogenic system, we analysed SVZ, RMS and OB sections of 14 aged brain donors (ages 74-93). GFAP-delta was expressed in the SVZ along the ventricle, in the RMS and in the OB. The GFAP-delta cells in the SVZ co-expressed the neural stem cell (NSC) marker nestin and the cell proliferation markers proliferating cell nuclear antigen (PCNA) and Mcm2. Furthermore, BrdU retention was found ...
Glial fibrillary acidic protein (GFAP), a 50 kDa protein, is a major intermediate filament protein in mature astrocytes. It is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in the GFAP gene in humans cause Alexander disease, a very rare, fatal neurodegenerative disease that mostly affects infants and children and results in developmental delay and changes in physical characteristics. GFAP is also known as FLJ45472.. ...
Glial fibrillary acidic protein (GFAP), a 50 kDa protein, is a major intermediate filament protein in mature astrocytes. It is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in the GFAP gene in humans cause Alexander disease, a very rare, fatal neurodegenerative disease that mostly affects infants and children and results in developmental delay and changes in physical characteristics. GFAP is also known as FLJ45472.. ...
Thirdly the Alexander Technique may improve the cerebellum, an area of the brain that has been linked with dyslexia and ADD, especially by Dore Centres / DDAT. The main role of the cerebellum is coordination of thoughts and actions, something which is often poor in children with learning difficulties. Through the Alexander Technique you learn to move your body in a controlled manner which requires you to learn a level of mental discipline. It should not be forgotten that the body is a very complex organism that is sending many different pieces of information to the brain: How hot am I? Where are my legs? What can my fingers feel? Do I need to go to the toilet? With all this information rushing into the brain, swamping the under-developed cerebellum, its conceivable that as a coping strategy the brain just ignores it. This could give rise to the clumsiness and inattentive behavior as the child is ignoring the signals the body sends it. With the Alexander Technique, it possible to become aware of ...
Michael J. Alexander, MD, has led and participated in numerous research projects funded by the National Institutes of Health (NIH) and industry. Over the past five years, his clinical research has focused on four primary areas: brain aneurysms (for example, Alexander was the institutional principal investigator for the Liberty trial and the FRED flow diverter trial), atherosclerotic disease (cholesterol plaque) of the carotid arteries and cerebral arteries (Alexander was a leader on the initial steering committee of the NIH-funded SAMMPRIS trial, was the institutional principal investigator on the SAPPHIRE WW carotid stent trial, and was the national principal investigator for the WEAVE intracranial stent trial), acute embolic stroke (he was co-investigator of the NIH-funded MR Rescue stroke trial and institutional principal investigator for the POSITIVE, THERAPY, START and PICS stroke trials), and cerebral (brain) hemorrhage (he was co-investigator in the NIH-funded MISTIE 3 and CLEAR 3 ...
THE #1 NEW YORK TIMES BESTSELLING ACCOUNT OF A NEUROSURGEONS OWN NEAR-DEATH EXPERIENCE.Internationally acclaimed neurosurgeon Dr Eben Alexander always considered himself a man of science. His unwavering belief in evidence-based medicine fuelled a career in the top medical institutions of the world. But all this was set to change. One morning in 2008 he fell into a coma after suffering a rare form of bacterial meningitis. Scans of his brain revealed massive damage. Death was deemed the most likely outcome. As his family prepared themselves for the worst, something miraculous happened. Dr Alexanders brain went from near total inactivity to awakening. He made a full recovery but he was never the same. He woke certain of the infinite reach of the soul, he was certain of a life beyond death. In this astonishing book, Dr Alexander shares his experience, pieced together from the notes he made as soon as he was able to write again. Unlike other accounts of near-death experiences, he is able to explain in
With Rockets owner Leslie Alexander announcing his first investment in China, a lease in the World City of Beijing development, and an advertising sponsorship with World City in Toyota Center, he was not the first member of the organization benefiting from the Yao Ming connection. Chuck Hayes (Li Ning) and Shane Battier (Peak) endorse Chinese basketball shoes. World City is the fifth company (of 22) with camera visible signage in Toyota Center. Battier had a 72-hour visit to Beijing before training camp and has a commercial that runs in China with a tour planned for next summer. Rockets owner Leslie Alexander laughed at the reports that his ex-wife Nanci Alexander, an avid animal rights activist, played a part in the NBA move to a synthetic basketball. Tracy McGradys concussion on Saturday might have knocked out some of his memory, but it brought back unhappy memories for Rockets forward Shane Battier. On Wednesday, the Rockets set or matched their season highs for points (118), first-quarter
RJ Fleck holds advanced degrees from the Universities of Toronto, California, and Stanford University in music performance, composition, computer science and digital audio engineering. He is an accomplished pianist, teaches music and managed a small digital audio research lab and residency (Mackenzie Post Digital) from his home in the Little Portugal neighbourhood of downtown Toronto for many years.. For the last several years, he has been increasingly devoting time to somatic and embodiment practices such as the Alexander Technique, Pilates, Tai Chi, Yoga and Vipassana Meditation. He completed certification at the Susan Sinclair Alexander Technique and Pilates Centre as a teacher of the Alexander Technique in 2007 and as an instructor of the Pilates Method in 2009. He certified as an instructor of Yoga with Octopus Garden in 2012.. ...
Struck in the name of King Philip III Arrhidaeus, Alexander the Greats half-brother, under the regent Perdikkas. Philip III and Alexanders infant son, Alexander IV, were made joint kings after Alexanders death. Philip was the bastard son of Philip II and a dancer, Philinna of Larissa. Alexander the Greats mother, Olympias, allegedly poisoned her stepson Philip III as a child, leaving him mentally disabled, eliminating him as a rival to Alexander. Neither Philip III nor Alexander IV was capable of actual rule and both were selected only to serve as pawns. The regents held power, while Philip III was actually imprisoned. In 317, Philip was murdered by Olympias to ensure the succession of her grandson.GS87632. Silver tetradrachm, Price P182, M ller Alexander P103, Demanhur 4601, SNG Munchen 969, SNG Cop 1077, SNG Saroglos -, VF, high relief, centered on a tight flan, rose toning, scratches and marks, some porosity, weight 16.902 g, maximum diameter 26.9 mm, die axis 270o, Mesopotamia, Babylon ...
Johns Thoughts: Not sure why Goldust is a 205 Live mainstay now. He even wrestled on this show. Are they building towards a Goldust and Cedric Alexander program because I dont think that would be the worst thing in the world with Goldust going back to that promising throwback heel character and Cedric needing some sort of character development. I would roll my eyes a bit at Cedric essentially taking the place of Ron Killings in this feud.. Enzo Amore made his entrance selling his injuries. He did his usual speech and the crowd wasnt as participatory to start but eventually the cheers built up. Enzo built up Tony Nese and called him "Tony Abs". Nese then did his unnecessarily long ass entrance while cutting his hard to hear his usual promo without a microphone. Cedric Alexander made his entrance to his remixed theme music. Its the same lyrics but theyve done some work editing the background music to the vocals…. 2. Tony Nese (w/Enzo Amore) vs. Cedric Alexander. Ugh. Tony Nese took steps ...
PCD Alexander City is a small dialysis clinic with 9 stations based at 3368 Highway 280 Bypass Suite G 1 in Alexander City, AL. The for-profit facility is operated independently from any other parent chain. The center was certified by Medicare in 2004. The facility offers in-center hemodialysis, hemo hemodialysis training, and in-center peritoneal services. The patient survival category for this clinic is average. ...
During an asthma attack, the airways narrow, causing breathing problems, wheezing and coughing. Asthma can be caused by allergies, pollens, stress or air pollution and can be fatal. The Alexander Technique is a form of therapy involving a series of movements designed to correct posture and bring the body into natural alignment and aid relaxation. The Alexander technique has been used by people with asthma, to try and improve breathing. The review of trials found there was not enough evidence to show the effects of the Alexander Technique in reducing the need to use medication for asthma. More research is needed.. ...
Alexander Ivanovitch Spiridovitch was born August 5, 1873 (old style) in the small town of Kemi in the Archangel government, on the shore of the White Sea. His father, Ivan Matveyovitch Spiridovitch was a Second Captain in command of a regiment of border guards.. The Spiridovitch family was listed in the Book of the Nobilitys Sixteenth section, having been granted a hereditary Noble Title by Tsar Alexis in 1668, and confirmed by an Ukaze which granted them land and serfs in the Smolensk region.. Second Capt. Spiridovitch immediately made a declaration of his sons birth to the Assembly of the Nobility of Smolensk for which he was given a certificate of Nobility in his sons name.. His father instilled in him as his guiding principles a love of God, Tsar and devotion to his country: For the Faith, For the Tsar and for the Nation was his motto.. However much his father loved young Alexander Ivanovitch, he was raised strictly in accordance with the customs of the era and later recalled that his ...
Congratulations to Alexander Szojka for receiving The Natural Sciences and Engineering Research Council of Canada (NSERC)s Alexander Graham Bell Canada Graduate Scholarship - Doctoral Program (CGS-D). The objective of the CGS-D program is to ensure a reliable supply of highly qualified personnel to meet the needs of Canadas knowledge economy. NSERC awards the CGS D to the top-ranked Postgraduate Scholarships-Doctoral (PGS D) applicants. This award will support his PhD research project in knee meniscus tissue engineering with his supervisor Dr. Adetola Adesida. Click button for a list of Alexander Szojkas most recent awards.. ...
Groklaws clone of Sarah Palin a.k.a. Pamela Jones has discovered her panties are all tied up in a wet, sloppy knot again over Alexander Terekhov: Ive been reading some of the amicus briefs filed in the In Re Bilski case pending before the US Supreme Court. There is an amicus brief [PDF] filed with the Supreme Court in the Bilski case that I think will interest you. It discusses software and whether it is math, it misrepresents FOSS, and it pushes software patents. It was filed by Professor Lee Hollaar and IEEE-USA. If that name sounds familiar, it should. Yes, this is the same Professor Hollaar that Alexander Terekhov and Daniel Wallace so often have quoted and linked to in their anti-GPL campaign here and elsewhere on the Internet... Professor Hollaars Amicus Brief in Bilski Tuesday, September 22 2009 @ 04:58 AM EDT http://www.groklaw.net/article.php?story=20090922030639824 Alexander! Whats your secret? How do you incite such passion in the fairer sex? Pheromones? Blond hair and blue ...
Get information, facts, and pictures about Alexander Graham Bell at Encyclopedia.com. Make research projects and school reports about Alexander Graham Bell easy with credible articles from our FREE, online encyclopedia and dictionary.
Online etext The travels and researches of Alexander von Humboldt by Alexander von Humboldt (page 1 of 35) : the collection of free ebooks
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The physician observed that he has treated several of Alexanders patients in the emergency room, including one woman in her second trimester whose uterus Alexander allegedly perforated during an abortion.. "Dr. Alexander perforated the womans uterus so badly that it was hanging on by two blood vessels," the physician wrote. "The decapitated head of a fetus was in the womans abdomen and the large intestine had been grasped and pulled away from its blood supply and into the vagina. The woman required a hysterectomy, colonoscopy, and several units of blood to save her life.". The physician added, "I, for one, was very happy to hear he is no longer practicing in Muskegon, but I fear for women anywhere this man would go." ...
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The search button below allows you to quickly search several key Alexander Technique websites for specific information about the Technique using key words or phrases of topics or, if youre searching for an Alexander Technique teacher in your area, location:. ...
Vitamins are essential for the normal growth and development of humans, and include vitamin A, vitamin B, vitamin C, vitamin C, vitamin D, vitamin E, vitamin K and many more. See below for local businesses in Alexander City that give access to vitamins as well as advice and content on fat-soluble vitamins and water-soluble vitamins.
Title: Vintage Madame Alexander Tagged Sweet Tears Pink Dress, 1965, Price: $30 USD, Category: Dolls:Vintage Dolls:Madame Alexander Baby Doll:Sweet Tears, Shop: Fourty Fifty Sixty, Description: We are pleased to offer for sale this original Madame Alexander Sweet Tears tagged party dress for the companys 13 vinyl baby doll that dates back to 1965. The dress is in a pink cotton material and
GeneReviews/NCBI/NIH/UW entry on Alexander disease OMIM entries on Alexander disease Glial Fibrillary Acidic Protein at the US ... "Alexander Disease". Medical College of Wisconsin. Hagemann TL, Connor JX, Messing A (Oct 2006). "Alexander disease-associated ... Chen YS, Lim SC, Chen MH, Quinlan RA, Perng MD (Oct 2011). "Alexander disease causing mutations in the C-terminal domain of ... GFAP therefore plays an important role in the pathogenesis of Alexander disease. Notably, the expression of some GFAP isoforms ...
Barreto, George E.; Iarkov, Alexander; Moran, Valentina Echeverria (January 2015). "Beneficial effects of nicotine, cotinine ... Illustration of Parkinson's disease by William Richard Gowers, first published in A Manual of Diseases of the Nervous System ( ... 2006). "Diagnosing Parkinson's Disease". Parkinson's Disease. London: Royal College of Physicians. pp. 29-47. ISBN 978-1-86016- ... Parkinson's Disease at Curlie. *Parkinson's Disease: Hope Through Research (National Institute of Neurological Disorders and ...
CYP11B1 Alexander disease; 203450; GFAP Alexander disease; 203450; NDUFV1 Alkaptonuria; 203500; HGD Allan-Herndon-Dudley ... RNF212 Refsum disease; 266500; PEX7 Refsum disease; 266500; PHYH Refsum disease, infantile form; 266510; PEX26 Refsum disease, ... PSEN1 Alzheimer disease-10; 104300; AD10 Alzheimer disease-2; 104310; APOE Alzheimer disease-4; 606889; PSEN2 Alzheimer disease ... RLBP1 Niemann-Pick disease, type A; 257200; SMPD1 Niemann-Pick disease, type B; 607616; SMPD1 Niemann-Pick disease, type C1; ...
Robyn Alexander. "Addison's Disease or Hypoadrenocorticism". Scwtca.org. Retrieved 15 April 2017. "SCWTDB.org , Soft Coated ... Other Wheaten health issues are renal dysplasia, inflammatory bowel disease, Addison's disease, and cancer. Some Wheatens can ... Robyn Alexander. "History of the Breed − Soft Coated Wheaten Terrier Club of America". Scwtca.org. Retrieved 11 December 2017. ... Robyn Alexander. "Soft Coated Wheaten Terrier Club of America - Wheaten Health". Swctca.org. Retrieved 11 December 2017. " ...
Alexander van Geen, et al. "Impact of population and latrines on fecal contamination of ponds in rural Bangladesh." Science Of ... Acute disease. An acute disease is a short-lived disease, like the common cold.. Chronic disease. A chronic disease is one that ... hereditary diseases (including both genetic diseases and non-genetic hereditary diseases), and physiological diseases. Diseases ... Subclinical disease. Also called silent disease, silent stage, or asymptomatic disease. This is a stage in some diseases before ...
Alexander van Geen, et al. "Impact of population and latrines on fecal contamination of ponds in rural Bangladesh." Science Of ... Acute disease. An acute disease is a short-lived disease, like the common cold.. Chronic disease. A chronic disease is one that ... It also sounds like it could imply secondary disease, but acquired disease can be primary disease.. Acute disease disease of a ... hereditary diseases (including both genetic diseases and non-genetic hereditary diseases), and physiological diseases. Diseases ...
Sanders, DA; Kobinger, GP (19 February 2015). "Transmission of Ebola viruses: what we know and what we do not know". mBio. 6 (2 ... Ebola virus disease at Curlie. *CDC: Ebola hemorrhagic fever - Centers for Disease Control and Prevention, Special Pathogens ... Main articles: Ebola virus cases in the United States, Ebola virus disease in Spain, and Ebola virus disease in the United ... "Ebola virus disease - Democratic Republic of the Congo - Disease outbreak news: Update 6 June 2019". World Health Organization ...
Quinlan RA, Brenner M, Goldman JE, Messing A (2007). "GFAP and its role in Alexander Disease". Exp Cell Res. 313 (10): 2077- ... include such diseases as Creutzfeldt-Jakob disease and other prion diseases, Alzheimer's disease, Parkinson's disease, ... disease]; proteopathies pl.; proteopathic adj.) refers to a class of diseases in which certain proteins become structurally ... Hardy J (2005). "Expression of normal sequence pathogenic proteins for neurodegenerative disease contributes to disease risk: ' ...
Pattison; McMullin; Bradbury; Alexander (2008). Poultry Diseases (6th ed.). Elsevier. p. 317. ISBN 978-0-7020-28625. "Seasonal ... The Center for Disease Control and Prevention (CDC) and the World Health Organization (WHO) are constantly surveying the wild ... Influenza (Flu)" Centers for Disease Control and Prevention. March 22, 2012. https://www.cdc.gov/flu/about/viruses/types.htm ...
Alexander, DJ. Poultry diseases (6th ed.). Edinburgh: Elsevier/Butterworth-Heinemann. pp. 451-452. ISBN 978-0-7020-2862-5. ... The parasite causes disease in the cecum, where, on post-mortem examination (necropsy), a cream-colored exudate is seen. EM, ... Diseases of poultry (12th ed.). Ames, Iowa: Blackwell Publishing. p. 1082. ISBN 978-0-8138-0718-8. ... Eimeria meleagridis is a species of coccidia found worldwide, which causes mild disease in young turkeys aged 4-8 weeks. ...
... see Alexander disease). Friedrich August von Ammon (1799-1861), German ophthalmologist and pathologist. Nikolay Anichkov (1885- ... Alexander A. Maximow (1874-1928), Russian-American scientist, histologist and embryologist. John McCrae (1872-1918), Canadian ... William Boog Leishman (1865-1926), English authority on the pathology of human parasitic diseases (see leishmaniasis) George ... Adolf Weil (1848-1916), German physician and pathologist (see Weil's disease). Ronald S. Weinstein (born 1938), American ...
Alexander Skene. Treatise on the Diseases of Women. D. Appleton & Co, New York, 1889. ASRM fact sheet Medpix pictures of ... As pelvic inflammatory disease is the major cause of hydrosalpinx formation, steps to reduce sexually transmitted disease will ... Not symptoms) The major cause for distal tubal occlusion is pelvic inflammatory disease (PID), usually as a consequence of an ...
Alexander (2006). "Multiple sclerosis as a vascular disease". Neurol. Res. 28 (3): 230-5. doi:10.1179/016164106X98080. PMID ... Sheremata WA, Jy W, Horstman LL, Ahn YS, Alexander JS, Minagar A.; Jy; Horstman; Ahn; Alexander; Minagar (2008). "Evidence of ... Currently it is unknown what the primary cause of MS is and, if MS turns out to be a heterogeneus disease, the lesion ... They have been proposed as biomarkers for the presence of the disease and its evolution and some of them like miR-150 are under ...
Alexander, D.J (2000). "Newcastle disease and other avian paramyxoviruses" (PDF). ... The most common serotype of avian paramyxovirus is serotype 1, the cause of Newcastle disease (ND). Avian paramyxovirus 2 has ... Avian paramyxovirus 2 has reservoirs in feral avian species and is known to cause respiratory disease and have economic impacts ... "Requirements for the Assembly and Release of Newcastle Disease Virus-Like Particles". Journal of Virology. 80 (22): 11062-11073 ...
Johnny Sanders died at home on September 29, 2012 from Alzheimer's Disease. He was an MD, and founded Sanders Clinic for Women ... During this period Johnny Sanders had quit and was replaced by Johnny Freeman, for a couple of gigs and a trip to Ca.. Then ... The Gants were formed shortly after by Sid Herring (lead vocals and guitar), Johnny Sanders (guitar), Vince Montgomery (bass ... After talking with Vince Montgomery (bass) and Don Wood (drums) Sid Herring replaced Freeman with Johnny Sanders. That's when ...
Subscription required (help)). Crichton, Alexander (1798). "On Attention and its diseases". An Inquiry Into the Nature and ... It may be either born with a person, or it may be the effect of accidental diseases. When born with a person it becomes evident ... Crichton further observed: In this disease of attention, if it can with propriety be called so, every impression seems to ... Scottish-born physician and author, Sir Alexander Crichton described a mental state much like the inattentive subtype of ADHD, ...
National Institute of Allergy and Infectious Diseases. Feb. 26, 1999 Infectious Diseases Society of America. Alexander Fleming ... He received the Alexander Fleming Award for Lifetime Achievement from the Infectious Diseases Society of America in 2011 and ... Haynes is a Fellow of the Infectious Diseases Society of America and is a member of the Association of American Physicians, the ... After conducting research for five years at the National Institute of Allergy and Infectious Diseases from 1975 to 1980, Haynes ...
Bundschuh, Matthias; Groneberg, David A; Klingelhoefer, Doris; Gerber, Alexander. "Yellow fever disease: density equalizing ... PMC 4349381 . Hay, Simon I. (ed.). "Yellow Fever in Africa: Estimating the Burden of Disease and Impact of Mass Vaccination ... Immunisation against infectious diseases. Great Britain: Department of Health. Retrieved 7 February 2017. Bethell, Leslie. ... "Yellow Fever Timeline: The History Of A Long Misunderstood Disease". npr.org. Retrieved 5 February 2017. Tomori, Oyewale. " ...
... are associated with Alexander disease". Nature Genetics. 27 (1): 117-20. doi:10.1038/83679. PMID 11138011. Bénit P, Chretien D ... liver disease, Leigh syndrome, Leber hereditary optic neuropathy, and some forms of Parkinson disease. GRCh38: Ensembl release ... It causes a wide range of clinical disorders, ranging from lethal neonatal disease to adult-onset neurodegenerative disorders. ...
Alexander William Mitchinson argued that flooding substantial areas would create disease-ridden swamps. Others were critical of ... Mitchinson, Alexander William (1881). The expiring continent: A narrative of travel in Senegambia, with observations on native ...
McKie, Robin; Rice, Xan (April 22, 2007). "Millions face famine as crop disease rages". Guardian. London.. ... As underweight children are more vulnerable to almost all infectious diseases, the indirect disease burden of malnutrition is ... Overeating leads to many diseases, such as heart disease and diabetes, that may result in death. ... This conditions may include Crohn's disease or untreated coeliac disease.[4][9][52] Malnutrition may also occur due to ...
Parasuraman, R.; P. M. Greenwood; G. E. Alexander (2000). "Alzheimer disease constricts the dynamic range of spatial attention ... Tales, A.; S. R. Butler; J. Fossey; I. D. Gilchrist; R. W. Jones; T. Troscianko (2002). "Visual search in Alzheimer's disease: ... Earlier work was carried out on patients with Parkinson's disease (PD) concerning the impairment patients with PD have on ... Mendez, M. F.; M. M. Cherrier; J. S. Cymerman (1997). "Hemispatial neglect on visual search tasks in Alzheimer's disease". ...
The disease is mostly found in central Europe in areas with light sandy soils. The loss of yield in sugarbeet can be up to 75% ... Dry plant material remains infectious for up to seven days and for twelve weeks at −20°C. The disease manifests itself by an ... Petherbridge, F.R.; Stirrup, H.H. (1935) Pests and diseases of the sugar beet. Bulletin of Ministry of Agriculture, Fisheries ...
... and Infectious Diseases, 26, 343-355. Alexander, A. D.; Flyger, V.; Herman, Y. F.; Mcconnell, S. J.; Rothstein, N.; Yager, R. H ... Controlling diseases such as the plague in wildlife and domestic animals is important to reducing its transmission to humans. ... Uses in veterinary medicine: have potential use for this treatment technique in infectious disease, ex vivo therapies, and ... RCN viral vectors have the potential to replace expensive and labor-intensive pesticide applications in disease prevention. ...
Hattie Alexander (infectious disease), William Silverman (neonatology), and John Caffey (radiology). McIntosh published ... son of Luther Emmett Holt) were the editors of select editions of the textbooks Holt's Diseases of Infancy and Childhood (10th ...
"Alexander Street.. Vassar College. Archives and Special Collections Library. *Benedict, Ruth. 1931. Tales of the Cochiti ... Fulton loved his work and research, it eventually led to his premature death, as he acquired an unknown disease during one of ... She enjoyed the class and took another anthropology course with Alexander Goldenweiser, a student of noted anthropologist Franz ...
Advantages: Pest / Disease Resistant, Attract Hummingbirds; Soil Type: Sandy Soil; Amount Of Rain: 10 to 20 ...
What is Alexander Disease? Compare Alexander Disease symptoms Alexander Disease treatments and . Share online in the health ... Learn about Alexander Disease and other health conditions at HealtheTreatment. ... it is more appropriate to consider Alexander disease a disease of astrocytes (an astrogliopathy) than a white matter disease ( ... Alexander disease is named after the physician who first described the condition in 1949 (WS Alexander). It is an extremely ...
Age of Onset, Aged, Alexander Disease, Brain Stem, Cells, Cultured, Exome, Female, Fibroblasts, Glial Fibrillary Acidic Protein ... Adult-onset Alexander disease, associated with a mutation in an alternative GFAP transcript, may be phenotypically modulated by ... Adult-onset Alexander disease, associated with a mutation in an alternative GFAP transcript, may be phenotypically modulated by ... Home Adult-onset Alexander disease, associated with a mutation in an alternative GFAP transcript, may be phenotypically ...
Alexander disease is a very rare disease with a variety of clinical phenotypes. Therefore serial magnetic resonance imaging ... Alexander disease was diagnosed by gene examination of the mutation of a glial fibrillary acidic protein. Magnetic resonance ... We report the five-year clinical course of Alexander disease in one case using serial magnetic resonance imaging. A 12-month- ... Alexander disease is a rare disorder resulting from a glial fibrillary acidic protein gene mutation which causes progressive ...
Infectious Diseases. David H. Martin, MD. Chief of the Section. The Infectious Diseases Section is committed to teaching ... Charles V. Sanders, MD. Head of the Department. Allergy and Clinical Immunology. Prem Kumar, MD. Chief of the Section ... ischemic heart disease, heart failure, and obstructive lung disease. Students also evaluate patients with residents and faculty ... Metabolic bone disease is also a condition that is covered. The didactic program is divided into both clinical and lecture ...
Alexander disease is a rare disorder of the nervous system. Explore symptoms, inheritance, genetics of this condition. ... medlineplus.gov/genetics/condition/alexander-disease/ Alexander disease. ... Zang L, Wang J, Jiang Y, Gu Q, Gao Z, Yang Y, Xiao J, Wu Y. Follow-up study of 22 Chinese children with Alexander disease and ... Alexander disease is a rare disorder of the nervous system. It is one of a group of disorders, called leukodystrophies, that ...
Alexander disease is a very rare disorder of the nervous system. Heres what causes it and how it can affect different age ... What is Alexander disease?. Alexander disease is a very rare disorder of the nervous system. Normally, nerve fibers are covered ... Alexander disease in older adults (65+). Its extremely rare for Alexander disease to develop this late in life. If it does, ... What causes this disease?. Alexander disease is caused by a defect in the glial fibrillary acidic protein (GFAP) gene in around ...
"MUTATION KEY TO ALEXANDER DISEASE" - United Press International GeneReviews/NCBI/NIH/UW entry on Alexander disease alexander_ ... Alexander disease may also be revealed by genetic testing for the known cause of Alexander disease. A rough diagnosis may also ... Alexander disease belongs to leukodystrophies, a group of diseases that affect the growth or development of the myelin sheath. ... Alexander disease, also known as fibrinoid leukodystrophy, is a progressive and fatal neurodegenerative disease. It is a rare ...
Alex provides operational support to the Co-Founder and Senior Leadership by reducing the time relationship managers spend on administrative tasks and by improving the engagement experience for MJFF constituents. He also contributes to the revenue strategy function of the DORA team by enhancing both visibility into revenue line performance and the efficient allocation of resources.
Two-year-olds parents with neurological disease similar to former Powell coachs children, Mabry Kate and Owen. Mabry Kate ... "Each child is so different with this disease," said Qwynn. "Hopefully there will be a lot of learning about the disease, we ... Parents of daughter with neurological disease hope for answers. Two-year-olds parents with neurological disease similar to ... Parents of daughter with neurological disease hope for answers Two-year-olds parents with neurological disease similar to ...
Alzheimers Disease Center. Welcome to the UK-ADC, one of the 10 original Alzheimers Disease Centers funded by the National ... Our principal mission is to serve as the focal point for all Alzheimers disease-related activities at the University of ... Center on Aging / Sanders-Brown Center of Aging Clinic (859) 323-6040 / (859) 323-5550 ... Home · About Us · Alzheimers Disease Center · Research & Resources · Community & Research Participants · Center on Aging ...
Sendes innen 5‑9 virkedager.. Kjøp boken Disease Dynamics av Alexander Asachenkov (ISBN 9780817636920) hos Adlibris.com. Fri ... This text discusses mathematical modelling, analysis and control of the immune system and disease dynamics. The purpose of the ... to provide a tutorial systematic description of how the immune system controls diseases and to present several significant ...
Friedrich-Alexander University is a training opportunity in Cornea-External Disease at Friedrich-Alexander University in ...
Alec Baldwin opened about about his struggles with Lyme disease for the first time since he casually mentioned it in a New York ... Alec Baldwin has opened about about his struggle with Lyme disease. The actor developed the bacterial disease when he was ... Talking about it: Alec Baldwin opened about about his struggles with Lyme disease for the first time since he casually ... Its Saturday! Alec Baldwin teaches daughter Carmen his... Sun worshipper! Hilaria Baldwin wears cut-off shorts and... Alec ...
What is the treatment for Alexander Disease?. There is no cure for Alexander Disease. The treatment for Alexander disease is ... Genetic Testing for Alexander Disease: www.Gene DX.com. What are the symptoms of Alexander Disease?. Symptoms vary between the ... Adult-onset Alexander Disease. Adult-onset Alexander Disease is the most rare of the forms, and also is generally the most mild ... Basic Facts About Alexander Disease. Alexander Disease has been divided into three forms based on age of onset and type of ...
Alexander Mayer, DO. Cardiology (Cardiovascular Disease), Internal MedicineCardiology (Cardiovascular Disease) , Internal ... AllergiesCancerDiabetes Type 2Heart DiseaseHypertensionQuitting SmokingWomens HealthSee All. ... AllergiesCancerDiabetes Type 2Heart DiseaseHypertensionQuitting SmokingWomens HealthSee All. ... Suzanne SteinbaumCardiology (Cardiovascular Disease), Internal Medicine. Dr. Arthur CrowleyUrology. See All. ...
Walker, Alexander R. P & Wadee, Ahmed A. (‎2002)‎. Preventing cardiovascular disease : a despondent view : letter / Alexander R ... Preventing cardiovascular disease : a despondent view : letter / Alexander R. P. Walker and Ahmed A. Wadee. ...
Buy a discounted Hardcover of Neurotoxic Factors in Parkinsons Disease and Related Disorders online from Australias leading ... Booktopia has Neurotoxic Factors in Parkinsons Disease and Related Disorders by Alexander Storch. ... Neurotoxic Factors in Parkinsons Disease and Related Disorders. By: Alexander Storch (Editor), Michael A. Collins (Editor). ... nd This book stems from the 2 Parkinsons Disease Symposium on "Neurotoxic Factors in Parkinsons disease and related disorders ...
Find 5 local Cardiovascular Disease Physicians practicing in Alexander City, AL. Read 5 ratings and reviews to help find the ...
It has been estimated that 75 per cent of this loss may be prevented by spraying - the chief method of fruit - disease control ... It is the common opinion of authorities that fruit-growers lose millions of dollars annually on account of diseases of their ... Manual Of Fruit Diseases , by Lex R. Hesler. It is the common opinion of authorities that fruit-growers lose millions of ... Apricot Diseases. The apricot is, as a rule, a very healthy tree. However, there are a few diseases which affect it to some ...
Can MR Imaging Diagnose Adult-Onset Alexander Disease?. L. Farina, D. Pareyson, L. Minati, I. Ceccherini, L. Chiapparini, S. ... Can MR Imaging Diagnose Adult-Onset Alexander Disease?. L. Farina, D. Pareyson, L. Minati, I. Ceccherini, L. Chiapparini, S. ... Can MR Imaging Diagnose Adult-Onset Alexander Disease?. L. Farina, D. Pareyson, L. Minati, I. Ceccherini, L. Chiapparini, S. ... Alexander disease. Ventricular garlands and abnormalities of the medulla and spinal cord. Neurology 2006;66:494-98. ...
Dynamics of mutated GFAP aggregates revealed by real-time imaging of an astrocyte model of Alexander disease.. Mignot C1, ... Alexander disease (AxD) is a rare neurodegenerative disorder characterized by large cytoplasmic aggregates in astrocytes and ... expressed in astrocytes formed networks or aggregates similar to those found in the brains of patients with the disease. Time- ...
Postdoctoral Position: Solution NMR of Disease-Linked Membrane Proteins, Lab of Chuck Sanders. Submitted by mariabaias on Mon, ... Postdoctoral Position: Solution NMR of Disease-Linked Membrane Proteins, Lab of Chuck Sanders ... Postdoctoral Position: Solution NMR of Disease-Linked Membrane Proteins, Lab of Chuck Sanders ... Postdoctoral Position: Solution NMR of Disease-Linked Membrane Proteins, Lab of Chuck Sanders ...
Alexander Myers who has 40 years of experience as a Cardiovascular Disease Physician in Taunton, MA. ... Type 2 diabetes is a chronic disease in which your body is unable to maintain a normal blood sugar (glucose) level. ... Alexander Myers is similar to the following 3 Doctors near Taunton, MA.. ...
Borrett D, Becker LE (1985) Alexanders disease. A disease of astrocytes. Brain 108 (Part 2):367-385.PubMedGoogle Scholar ... Messing A, Goldman JE (2004) Alexander disease. In: Lazzarini RA, ed), Myelin and its diseases (Elsevier Academic Press. San ... Seil FJ, Schochet SS Jr, Earle KM (1968) Alexanders disease in an adult. Report of a case. Arch Neurol 19:494-502.PubMedGoogle ... Quinlan RA, Brenner M, Goldman JE, Messing A (2007) GFAP and its role in Alexander disease. Exp Cell Res 313:2077-2087.PubMed ...
  • They officially shared the news with concerned family and friends via a dedicated Facebook page, "Moving with Meris - Our Journey with Alexander Disease" on Dec. 31, 2017. (knoxnews.com)
  • Hemorrhoids & Thyroid Disease" last modified May 13, 2017. (ehow.co.uk)
  • Alec Baldwin has opened about about his struggle with Lyme disease. (dailymail.co.uk)
  • I got the classic Lyme disease (symptoms) for each successive summer, for five years, every August, like this black lung, flu-like symptoms, sweating to death in my bed,' the 59-year-old said, as reported by People Magazine. (dailymail.co.uk)
  • The former international model has been chronicling her efforts to combat Lyme disease on social media. (dailymail.co.uk)
  • I was lying in bed saying, 'I'm going to die of Lyme disease in my bed' and 'I hope someone finds me and I'm not here for too long,' he continued. (dailymail.co.uk)
  • Lyme disease, or Lyme borreliosis, is a bacterial infection spread to humans by infected ticks. (dailymail.co.uk)
  • Those that carry the bacteria responsible for Lyme disease are found throughout the UK and in other parts of Europe and North America. (dailymail.co.uk)
  • Many people with early-stage Lyme disease develop a distinctive circular rash at the site of the tick bite, usually around 3 to 30 days after being bitten. (dailymail.co.uk)
  • More serious symptoms may develop several weeks, months or even years later if Lyme disease is left untreated or is not treated early. (dailymail.co.uk)
  • Lyme disease can also lead to heart problems such as myocarditis, where the heart muscle becomes inflamed and heart failure. (dailymail.co.uk)
  • A small minority of people go on to develop long-term symptoms similar to those of fibromyalgia or chronic fatigue syndrome, called post-infectious Lyme disease. (dailymail.co.uk)
  • I got the classic Lyme disease (symptoms) for each successive summer, for five years, every August, like this black lung, flu-like symptoms, sweating to death in my bed," the Hollywood star explained to People during an appearance at Bay Area Lyme Foundation's LymeAid benefit. (hellomagazine.com)
  • Other known sufferers of Lyme disease include Kelly Osbourne , Avril Lavigne and Bella Hadid , who said her teenage years were "taken" from her due to the disease. (hellomagazine.com)
  • While Lyme disease can often be treated effectively if it's detected early on, there's a risk that you can develop severe and long-lasting symptoms if treatment is delayed. (hellomagazine.com)
  • I find it amazing that Eugene Shaprio is being quoted as a lyme disease expert. (healingwell.com)
  • Common problems in juvenile and adult forms of Alexander disease include speech abnormalities, swallowing difficulties, seizures, and poor coordination (ataxia). (medlineplus.gov)
  • Patients with the juvenile and adult forms of Alexander disease typically experience ataxia and spasticity and a more slowly progressive course. (drugster.info)
  • The juvenile and adult form of the disease is less common and have mental and physical effects including speech abnormalities, swallowing difficulty, seizures, poor coordination (ataxia), dysarthria and excessive vomiting. (newyorkessays.com)
  • The course of the disease may involve signs of swallowing or speech difficulty, vomiting, ataxia and/or spasticity. (nationalstemcellfoundation.org)
  • Jonathan Schisler, MS, PhD, led research showing that limiting the activity of a mutant CHIP protein could decrease symptom severity for people with cerebral ataxia, a debilitating disease of the nervous system. (unchealthcare.org)
  • Here we describe the first discovered instance of a primary astrogliopathy , in which a defect in astrocytes indeed results in a human disorder - Alexander disease. (springer.com)
  • Alexander WS (1949) Progressive fibrinoid degeneration of fibrillary astrocytes associated with mental retardation in a hydrocephalic infant. (springer.com)
  • We established induced pluripotent stem cells from Alexander disease patients, and differentiated induced pluripotent stem cells into astrocytes. (biomedcentral.com)
  • Astrocytes, differentiated from induced pluripotent stem cells of Alexander disease, could be a cellular model for future translational medicine. (biomedcentral.com)
  • In addition to the 10 patients in whom AOAD was genetically confirmed, an eleventh patient whose AOAD was not genetically confirmed who presented clinical and radiologic findings identical to those observed in the other 10 patients with AOAD was included in the present series because he also had autosomal dominant disease transmission. (ajnr.org)
  • Sandy Ford with vials of pentamidine for distribution to patients with Pneumocystis pneumonia. (cdc.gov)
  • Sandy interacted skillfully with hundreds of clinicians across the United States to provide life-saving pentamidine to severely ill patients, and she kept very careful records. (cdc.gov)
  • Two weeks later, another New York physician told Sandy about 5 male patients who had both PCP and Kaposi sarcoma. (cdc.gov)
  • Sandy learned that the sexual orientation for all these patients was homosexual. (cdc.gov)
  • It has a special outpatient clinic which treats patients with chronic inflammatory bowel disease and several working groups at the Department are carrying out research into the cellular and molecular causes of the disease and new forms of treatment. (fau.eu)
  • One of the first signs of Hashimoto's disease for many patients is an enlarged thyroid , colloquially referred to as a goiter . (anti-aging-bhrt.com)
  • Accepting new patients: Yes, Dr. Alexander Chernobelsky is accepting new patients at his office. (topnpi.com)
  • Alexander Mitchell, 20, of Provo, Utah, is one of five patients treated at the University of Utah Hospital for severe vaping-related lung injuries. (hotinfonow.com)
  • This program allows patients and researchers to connect as easily as possible to help advance treatments and cures for rare diseases. (rareshare.org)
  • However, these questions are important to patients and their families to create awareness as well as to researchers to study rare diseases. (rareshare.org)
  • For the thousands of patients with eye diseases who have received this form of acupuncture treatment, 70-83% respond to treatment, depending on the type of eye disease. (sandycamper.com)
  • Michael E. Cobble, MD, the director and family practice physician​ at Canyons Medical Center, has extensive experience in managing patients who have chronic diseases using a holistic approach for optimal results. (canyonsmedical.com)
  • Many types of chronic disease are incurable, but if patients and their health care providers manage these conditions carefully, it's very often possible to live a long and rewarding life. (canyonsmedical.com)
  • Wasserstein M, Godbold J, McGovern MM. Skeletal manifestations in pediatric and adult patients with Niemann Pick disease type B. J Inherit Metab Dis . (medscape.com)
  • Screening of high-risk Gaucher disease patients in Brazil using miniaturized dried blood spots and leukocyte techniques. (medscape.com)
  • And Hermann-Lingen, C. (2004) Depression as a risk factor for mortality in patients with coronary heart disease: a metaanalysis. (unitecllc.com)
  • Medicinal treatment which targets this molecule could potentially protect patients from this feared disease. (fau.eu)
  • Chronic liver diseases are among the leading causes of death in the USA and the number of patients with diseased livers in Germany is increasing. (fau.eu)
  • Stefan Wirtz and his team were able to prove that interleukin 33 levels in the blood of patients with liver diseases is much higher than in control groups. (fau.eu)
  • This could help patients make lifestyle decisions that may stop the disease advancing any further. (fau.eu)
  • Truth is, it's not easy being a Baldwin , which I'm not, but I believe I've gained a good understanding as to why Alec has gotten so damn fat. (blogspot.com)
  • Alexander Gordon Bearn - (born March 29, 1923) was Executive Officer of the American Philosophical Society from 1997 until his retirement in 2002. (academic.ru)
  • Research trials, including a Randomised Controlled Trial, were carried out in 1997, 2002 and 2005 on the effectiveness of the Alexander Technique in helping those with Parkinson's. (alexandertechniqueinessex.co.uk)
  • and in epidemiology, several recent major studies ofPD - for example, a study of20,000 twins published in the Journal of the American Medical Association in 1999 - conclude that environmental and life style than genetics, appear to be critical in the idiopathic disease. (booktopia.com.au)
  • Welcome to the UK-ADC, one of the 10 original Alzheimer's Disease Centers funded by the National Institutes of Health. (uky.edu)
  • Centers for Disease Control and Prevention. (cdc.gov)
  • In January 1979, Sandy took a position in the Parasitic Diseases Division in the Centers for Disease Control, now the Centers for Disease Control and Prevention (CDC). (cdc.gov)
  • In his bestselling book And the Band Played On, which chronicled the discovery of AIDS, Randy Shilts said, "That was how the thorough GS-7 drug technician in Room 161 of the Centers for Disease Control's Building 6 alerted the federal government to the new epidemic" ( 1 ). (cdc.gov)
  • Saving Lives, Protecting People Centers for Disease Control and Prevention. (cdc.gov)
  • Although the cases appear to be similar, staff at the Centers for Disease Control and Prevention are careful not to know if the diseases are related to the electronic cigarette devices themselves or to the specific ingredients or pollutants that are inhaled through them. (hotinfonow.com)
  • According to the Centers for Disease Control and Prevention, HMFD is a common viral illness that usually affects infants and children younger than 5. (pamplinmedia.com)
  • New disease entities based on MRI and clinical patterns have been defined through the committed collaboration of neurologists in medical centers around the world. (rarediseases.org)
  • Dr Klimov began his career at the Centers for Disease Control and Prevention (CDC), Atlanta, Georgia, USA, following a career of great distinction at the Research Institute for Viral Preparations in Moscow, Russia, where in 1986 he became director of the World Health Organization (WHO) Collaborating Center for Molecular Biology and Genetics of Epidemic and Vaccine Influenza Virus Strains and head of the Laboratory of Genetics of RNA Viruses. (cdc.gov)
  • The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. (cdc.gov)
  • Some rare diseases appear to be completely determined by the genome, whereas more common diseases arise from a complex interplay of many genes, the environment and chance. (coursera.org)
  • The overall goal of this course is to describe how the researchers find genes responsible for different diseases and how this information is used to better understand and fight these diseases. (coursera.org)
  • Alexander disease is a genetic disorder affecting the midbrain and cerebellum of the central nervous system. (wikipedia.org)
  • Children with hydrocephalus caused by Alexander disease usually have increased intracranial pressure and a more rapid progression of the disease. (ulf.org)
  • Our studies will open new venues to regulation of immune responses through controlling the lifespan of APC and to prevention of development of autoimmune diseases. (grantome.com)
  • Dr Klimov was also a regular reviewer of papers submitted to Emerging Infectious Diseases, the Journal of Clinical Virology, the Journal of Virological Methods, Vaccine, Virology, and Virus Research, and he was a member of the editorial board of Voprosy Virusologii (Russia). (cdc.gov)
  • It is important for schools and communities to monitor multiple indicators of COVID-19 among school-aged children and layer prevention strategies to reduce COVID-19 disease risk for students, teachers, school staff, and families. (cdc.gov)
  • In this role her primary responsibility was to supervise and support the National Institutes of Health Office of Disease Prevention's (NIH-ODP) prevention research taxonomy project. (cdc.gov)
  • Now we have managed to identify an immunological factor which contributes to causing this disease for the first time, which opens up promising methods for treatment or even prevention. (fau.eu)
  • It provides researchers with a centralized, international patient registry for all rare diseases. (rareshare.org)
  • The CoRDS team works with patient advocacy groups, individuals and researchers to help in the advancement of research in over 7,000 rare diseases. (rareshare.org)
  • Researchers can contact CoRDS to determine if the registry contains participants with the rare disease they are researching. (rareshare.org)
  • The researchers also confirmed that interleukin 33 activates ILC2 immune cells, which had not been previously associated with liver disease. (fau.eu)
  • Researchers have discovered that large numbers of North American cats carry antibodies for the disease (meaning that the cats have been infected at some point in their lives). (encyclopedia.com)
  • 2019. https://peds.unboundmedicine.com/pedscentral/view/5-Minute-Pediatric-Consult/617875/all/Alexander_disease. (unboundmedicine.com)
  • Analysis of demographic characteristics, underlying conditions, clinical outcomes, and trends in weekly coronavirus disease 2019 (COVID-19) incidence during March 1-September 19, 2020 among 277,285 laboratory-confirmed cases in school-aged children in the United States might inform decisions about in-person learning and the timing and scaling of community mitigation measures. (cdc.gov)
  • Lexington Medical Center is pleased to present a physician lecture called "Advances in Surgical Management of Thyroid Disease" on Monday, April 28, 2014 at 6:00 p.m. inside the Lexington Medical Park 1 Auditorium on the hospital campus. (lexmed.com)
  • Vermont senator and presidential candidate Bernie Sanders is in "very good health," according to a letter from the attending U.S. Senate physician . (gawker.com)
  • Up to a few years ago, Alexander disease (AD) was known as a rare, genetically determined leukoencephalopathy affecting infants and children, characterized by macrocephaly, seizures, spasticity, and retarded psychomotor development, and leading to death in 2 months to 7 years. (ajnr.org)