Rare leukoencephalopathy with infantile-onset accumulation of Rosenthal fibers in the subpial, periventricular, and subependymal zones of the brain. Rosenthal fibers are GLIAL FIBRILLARY ACIDIC PROTEIN aggregates found in ASTROCYTES. Juvenile- and adult-onset types show progressive atrophy of the lower brainstem instead. De novo mutations in the GFAP gene are associated with the disease with propensity for paternal inheritance.
An intermediate filament protein found only in glial cells or cells of glial origin. MW 51,000.
One of the alpha crystallin subunits. In addition to being expressed in the lens (LENS, CRYSTALLINE), alpha-crystallin B chain has been found in a variety of tissues such as HEART; BRAIN; MUSCLE; and KIDNEY. Accumulation of the protein in the brain is associated with NEURODEGENERATIVE DISEASES such as CREUTZFELDT-JAKOB SYNDROME and ALEXANDER DISEASE.
A class of large neuroglial (macroglial) cells in the central nervous system - the largest and most numerous neuroglial cells in the brain and spinal cord. Astrocytes (from "star" cells) are irregularly shaped with many long processes, including those with "end feet" which form the glial (limiting) membrane and directly and indirectly contribute to the BLOOD-BRAIN BARRIER. They regulate the extracellular ionic and chemical environment, and "reactive astrocytes" (along with MICROGLIA) respond to injury.
Pathologic conditions affecting the BRAIN, which is composed of the intracranial components of the CENTRAL NERVOUS SYSTEM. This includes (but is not limited to) the CEREBRAL CORTEX; intracranial white matter; BASAL GANGLIA; THALAMUS; HYPOTHALAMUS; BRAIN STEM; and CEREBELLUM.
The age, developmental stage, or period of life at which a disease or the initial symptoms or manifestations of a disease appear in an individual.
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
A condition marked by raised intracranial pressure and characterized clinically by HEADACHES; NAUSEA; PAPILLEDEMA, peripheral constriction of the visual fields, transient visual obscurations, and pulsatile TINNITUS. OBESITY is frequently associated with this condition, which primarily affects women between 20 and 44 years of age. Chronic PAPILLEDEMA may lead to optic nerve injury (see OPTIC NERVE DISEASES) and visual loss (see BLINDNESS).
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
Increased pressure within the cranial vault. This may result from several conditions, including HYDROCEPHALUS; BRAIN EDEMA; intracranial masses; severe systemic HYPERTENSION; PSEUDOTUMOR CEREBRI; and other disorders.

The clinicopathological spectrum of Rosenthal fibre encephalopathy and Alexander's disease: a case report and review of the literature. (1/47)

Alexander's disease is a leucodystrophy that usually presents in early childhood, but can infrequently arise in adults. It is characterised pathologically by megalencephaly, demyelination, and the presence of numerous Rosenthal fibres. Most cases have been shown to be due to mutations in the gene encoding glial fibrillary acidic protein. In rare instances, numerous Rosenthal fibres have been found at autopsy in patients who have suffered protracted debilitating systemic illnesses, some with associated brain stem signs, and in very rare instances in patients with no apparent neurological abnormality. The term "Rosenthal fibre encephalopathy" is used to distinguish these cases from those of Alexander's disease. We report the first case of Rosenthal fibre encephalopathy in a young man with AIDS, and review the literature.  (+info)

Alexander-disease mutation of GFAP causes filament disorganization and decreased solubility of GFAP. (2/47)

Alexander disease is a fatal neurological illness characterized by white-matter degeneration and the formation of astrocytic cytoplasmic inclusions called Rosenthal fibers, which contain the intermediate filament glial fibrillary acidic protein (GFAP), the small heat-shock proteins HSP27 and alphaB-crystallin, and ubiquitin. Many Alexander-disease patients are heterozygous for one of a set of point mutations in the GFAP gene, all of which result in amino acid substitutions. The biological effects of the most common alteration, R239C, were tested by expressing the mutated protein in cultured cells by transient transfection. In primary rat astrocytes and Cos-7 cells, the mutant GFAP was incorporated into filament networks along with the endogenous GFAP and vimentin, respectively. In SW13Vim(-) cells, which have no endogenous cytoplasmic intermediate filaments, wild-type human GFAP frequently formed filamentous bundles, whereas the R239C GFAP formed 'diffuse' and irregular patterns. Filamentous bundles of R239C GFAP were sometimes formed in SW13Vim(-) cells when wild-type GFAP was co-transfected. Although the presence of a suitable coassembly partner (vimentin or GFAP) reduced the potential negative effects of the R239C mutation on GFAP network formation, the mutation affected the stability of GFAP in cells in a dominant fashion. Extraction of transfected SW13Vim(-) cells with Triton-X-100-containing buffers showed that the mutant GFAP was more resistant to solubilization at elevated KCl concentrations. Both wild-type and R239C GFAP assembled into 10 nm filaments with similar morphology in vitro. Thus, although the R239C mutation does not appear to affect filament formation per se, the mutation alters the normal solubility and organization of GFAP networks.  (+info)

Gene expression analysis in mice with elevated glial fibrillary acidic protein and Rosenthal fibers reveals a stress response followed by glial activation and neuronal dysfunction. (3/47)

Alexander disease is a fatal neurodegenerative disorder resulting from missense mutations of the intermediate filament protein, GFAP. The pathological hallmark of this disease is the formation of cytoplasmic protein aggregates within astrocytes known as Rosenthal fibers. Transgenic mice engineered to over-express wild-type human GFAP develop an encephalopathy with identical aggregates, suggesting that elevated levels of GFAP in addition to mutant protein contribute to the pathogenesis of this disorder. To study further the effects of elevated GFAP and Rosenthal fibers per se, independent of mutations, we performed gene expression analysis on olfactory bulbs of transgenic mice at two different ages to follow the progression of pathology. The expression profiles reveal a stress response that includes genes involved in glutathione metabolism, peroxide detoxification and iron homeostasis. Many of these genes are regulated by the transcription factor Nfe2l2, which is also increased in expression at 3 weeks. An immune-related response occurs with activation of cytokine and cytokine receptor genes, complement components and acute phase response genes. These transcripts are further elevated with age, with additional induction of macrophage-specific markers such as Mac1 and CD68, suggesting activation of microglia. At 4 months, decreased expression of genes for microtubule-associated proteins, vesicular trafficking proteins and neurotransmitter receptors becomes apparent. Interneuron-specific transcription factors including Dlx family members and Pax6 are downregulated as well as Gad1 and Gad2, suggesting impairment of GABAergic granule cells. Together, these data implicate an initial stress response by astrocytes, which results in the activation of microglia and compromised neuronal function.  (+info)

Plectin regulates the organization of glial fibrillary acidic protein in Alexander disease. (4/47)

Alexander disease (AxD) is a rare but fatal neurological disorder caused by mutations in the astrocyte-specific intermediate filament protein glial fibrillary acidic protein (GFAP). Histologically, AxD is characterized by cytoplasmic inclusion bodies called Rosenthal fibers (RFs), which contain GFAP, small heat shock proteins, and other undefined components. Here, we describe the expression of the cytoskeletal linker protein plectin in the AxD brain. RFs displayed positive immunostaining for plectin and GFAP, both of which were increased in the AxD brain. Co-localization, co-immunoprecipitation, and in vitro overlay analyses demonstrated direct interaction of plectin and GFAP. GFAP with the most common AxD mutation, R239C (RC GFAP), mainly formed abnormal aggregates in human primary astrocytes and murine plectin-deficient fibroblasts. Transient transfection of full-length plectin cDNA converted these aggregates to thin filaments, which exhibited diffuse cytoplasmic distribution. Compared to wild-type GFAP expression, RC GFAP expression lowered plectin levels in astrocytoma-derived stable transfectants and plectin-positive fibroblasts. A much higher proportion of total GFAP was found in the Triton X-insoluble fraction of plectin-deficient fibroblasts than in wild-type fibroblasts. Taken together, our results suggest that insufficient amounts of plectin, due to RC GFAP expression, promote GFAP aggregation and RF formation in AxD.  (+info)

Neuropathology for the neuroradiologist: Rosenthal fibers. (5/47)

Distinctive intracellular structures known as inclusions may be occasionally observed on stained tissue preparations and may further suggest a specific diagnosis. Pathologists rely on these findings much as radiologists rely on findings revealed in the gray-scale patterns of densities and intensities on images. Appreciation of these inclusions can enhance the interactions of the neuroradiologist with the neuropathologist and deepen understanding of certain conditions. This report reviews the neuropathologically observed intracellular inclusions known as Rosenthal fibers in the context of Alexander disease and slow-growing tumors such as pilocytic astrocytoma.  (+info)

The Alexander disease-causing glial fibrillary acidic protein mutant, R416W, accumulates into Rosenthal fibers by a pathway that involves filament aggregation and the association of alpha B-crystallin and HSP27. (6/47)

Here, we describe the early events in the disease pathogenesis of Alexander disease. This is a rare and usually fatal neurodegenerative disorder whose pathological hallmark is the abundance of protein aggregates in astrocytes. These aggregates, termed "Rosenthal fibers," contain the protein chaperones alpha B-crystallin and HSP27 as well as glial fibrillary acidic protein (GFAP), an intermediate filament (IF) protein found almost exclusively in astrocytes. Heterozygous, missense GFAP mutations that usually arise spontaneously during spermatogenesis have recently been found in the majority of patients with Alexander disease. In this study, we show that one of the more frequently observed mutations, R416W, significantly perturbs in vitro filament assembly. The filamentous structures formed resemble assembly intermediates but aggregate more strongly. Consistent with the heterozygosity of the mutation, this effect is dominant over wild-type GFAP in coassembly experiments. Transient transfection studies demonstrate that R416W GFAP induces the formation of GFAP-containing cytoplasmic aggregates in a wide range of different cell types, including astrocytes. The aggregates have several important features in common with Rosenthal fibers, including the association of alpha B-crystallin and HSP27. This association occurs simultaneously with the formation of protein aggregates containing R416W GFAP and is also specific, since HSP70 does not partition with them. Monoclonal antibodies specific for R416W GFAP reveal, for the first time for any IF-based disease, the presence of the mutant protein in the characteristic histopathological feature of the disease, namely Rosenthal fibers. Collectively, these data confirm that the effects of the R416W GFAP are dominant, changing the assembly process in a way that encourages aberrant filament-filament interactions that then lead to protein aggregation and chaperone sequestration as early events in Alexander disease.  (+info)

Synergistic effects of the SAPK/JNK and the proteasome pathway on glial fibrillary acidic protein (GFAP) accumulation in Alexander disease. (7/47)

Protein aggregates in astrocytes that contain glial fibrillary acidic protein (GFAP), small heat shock proteins, and ubiquitinated proteins are termed Rosenthal fibers and characterize Alexander disease, a leukodystrophy caused by heterozygous mutations in GFAP. The mechanisms responsible for the massive accumulation of GFAP in Alexander disease remain unclear. In this study, we show that overexpression of both wild type and R239C mutant human GFAP led to cytoplasmic inclusions. GFAP accumulation also led to a decrease of proteasome activity and an activation of the MLK2-JNK pathway. In turn, the expression of activated mixed lineage kinases (MLKs) induced JNK activation and increased GFAP accumulation, whereas blocking the JNK pathway decreased GFAP accumulation. Activated MLK also inhibited proteasome function. A direct inhibition of proteasome function pharmacologically further activated JNK. Our data suggest a synergistic interplay between the proteasome and the SAPK/JNK pathway in the context of GFAP accumulation. Feedback interactions among GFAP accumulation, SAPK/JNK activation, and proteasomal hypofunction cooperate to produce further protein accumulation and cellular stress responses.  (+info)

A case of infantile Alexander disease accompanied by infantile spasms diagnosed by DNA analysis. (8/47)

Alexander disease (AD) is a rare leukodystrophy of the central nervous system of unknown etiology. AD is characterized by progressive failure of central myelination and the accumulation of Rosenthal fibers in astrocytes, and is inevitably lethal in nature. Symptomatically, AD is associated with leukoencephalopathy with macrocephaly, seizures, and psychomotor retardation in infants, and usually leads to death within the first decade. Its characteristic magnetic resonance imaging (MRI) findings have been described as demyelination predominantly in the frontal lobe. Moreover, dominant mutations in the GFAP gene, coding for glial fibrillary acidic protein (GFAP), a principal astrocytic intermediate filament protein, have been shown to lead to AD. The disease can now be detected by genetic diagnosis. We report the Korean case of an 8-month-old male patient with AD. He was clinically characterized due to the presence of psychomotor retardation, megalencephaly, spasticity, and recurrent seizures including infantile spasms which is a remarkable presentation. Demyelination in the frontal lobe and in a portion of the temporal lobe was demonstrated by brain MRI. Moreover, DNA analysis of peripheral blood showed the presence of a R239L mutation in the GFAP gene, involving the replacement of guanine with thymine.  (+info)

Alexander disease is a rare, progressive, and typically fatal neurological disorder that primarily affects the central nervous system. It is caused by mutations in the gene that provides instructions for making the glial fibrillary acidic protein (GFAP), which is a component of the supportive cells in the brain called astrocytes.

The disease is characterized by the accumulation of abnormal GFAP proteins, which form aggregates known as Rosenthal fibers. These deposits can cause damage to surrounding nerve cells and lead to symptoms such as developmental delay, seizures, spasticity, ataxia, and bulbar dysfunction (difficulty with speaking, swallowing, and breathing).

Alexander disease is classified into three types based on the age of onset and severity of symptoms. Type 1, or the infantile form, is the most common and severe type, typically presenting in the first two years of life. Types 2 and 3 are less common and have later onset, with Type 2 affecting children and adolescents and Type 3 affecting adults.

Currently, there is no cure for Alexander disease, and treatment is focused on managing symptoms and improving quality of life.

Glial Fibrillary Acidic Protein (GFAP) is a type of intermediate filament protein that is primarily found in astrocytes, which are a type of star-shaped glial cells in the central nervous system (CNS). These proteins play an essential role in maintaining the structural integrity and stability of astrocytes. They also participate in various cellular processes such as responding to injury, providing support to neurons, and regulating the extracellular environment.

GFAP is often used as a marker for astrocytic activation or reactivity, which can occur in response to CNS injuries, neuroinflammation, or neurodegenerative diseases. Elevated GFAP levels in cerebrospinal fluid (CSF) or blood can indicate astrocyte damage or dysfunction and are associated with several neurological conditions, including traumatic brain injury, stroke, multiple sclerosis, Alzheimer's disease, and Alexander's disease.

Alpha-Crystallin B chain is a protein that is a component of the eye lens. It is one of the two subunits of the alpha-crystallin protein, which is a major structural protein in the lens and helps to maintain the transparency and refractive properties of the lens. Alpha-Crystallin B chain is produced by the CRYAB gene and has chaperone-like properties, helping to prevent the aggregation of other proteins and contributing to the maintenance of lens clarity. Mutations in the CRYAB gene can lead to various eye disorders, including cataracts and certain types of glaucoma.

Astrocytes are a type of star-shaped glial cell found in the central nervous system (CNS), including the brain and spinal cord. They play crucial roles in supporting and maintaining the health and function of neurons, which are the primary cells responsible for transmitting information in the CNS.

Some of the essential functions of astrocytes include:

1. Supporting neuronal structure and function: Astrocytes provide structural support to neurons by ensheathing them and maintaining the integrity of the blood-brain barrier, which helps regulate the entry and exit of substances into the CNS.
2. Regulating neurotransmitter levels: Astrocytes help control the levels of neurotransmitters in the synaptic cleft (the space between two neurons) by taking up excess neurotransmitters and breaking them down, thus preventing excessive or prolonged activation of neuronal receptors.
3. Providing nutrients to neurons: Astrocytes help supply energy metabolites, such as lactate, to neurons, which are essential for their survival and function.
4. Modulating synaptic activity: Through the release of various signaling molecules, astrocytes can modulate synaptic strength and plasticity, contributing to learning and memory processes.
5. Participating in immune responses: Astrocytes can respond to CNS injuries or infections by releasing pro-inflammatory cytokines and chemokines, which help recruit immune cells to the site of injury or infection.
6. Promoting neuronal survival and repair: In response to injury or disease, astrocytes can become reactive and undergo morphological changes that aid in forming a glial scar, which helps contain damage and promote tissue repair. Additionally, they release growth factors and other molecules that support the survival and regeneration of injured neurons.

Dysfunction or damage to astrocytes has been implicated in several neurological disorders, including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS).

Brain diseases, also known as neurological disorders, refer to a wide range of conditions that affect the brain and nervous system. These diseases can be caused by various factors such as genetics, infections, injuries, degeneration, or structural abnormalities. They can affect different parts of the brain, leading to a variety of symptoms and complications.

Some examples of brain diseases include:

1. Alzheimer's disease - a progressive degenerative disorder that affects memory and cognitive function.
2. Parkinson's disease - a movement disorder characterized by tremors, stiffness, and difficulty with coordination and balance.
3. Multiple sclerosis - a chronic autoimmune disease that affects the nervous system and can cause a range of symptoms such as vision loss, muscle weakness, and cognitive impairment.
4. Epilepsy - a neurological disorder characterized by recurrent seizures.
5. Brain tumors - abnormal growths in the brain that can be benign or malignant.
6. Stroke - a sudden interruption of blood flow to the brain, which can cause paralysis, speech difficulties, and other neurological symptoms.
7. Meningitis - an infection of the membranes surrounding the brain and spinal cord.
8. Encephalitis - an inflammation of the brain that can be caused by viruses, bacteria, or autoimmune disorders.
9. Huntington's disease - a genetic disorder that affects muscle coordination, cognitive function, and mental health.
10. Migraine - a neurological condition characterized by severe headaches, often accompanied by nausea, vomiting, and sensitivity to light and sound.

Brain diseases can range from mild to severe and may be treatable or incurable. They can affect people of all ages and backgrounds, and early diagnosis and treatment are essential for improving outcomes and quality of life.

The "age of onset" is a medical term that refers to the age at which an individual first develops or displays symptoms of a particular disease, disorder, or condition. It can be used to describe various medical conditions, including both physical and mental health disorders. The age of onset can have implications for prognosis, treatment approaches, and potential causes of the condition. In some cases, early onset may indicate a more severe or progressive course of the disease, while late-onset symptoms might be associated with different underlying factors or etiologies. It is essential to provide accurate and precise information regarding the age of onset when discussing a patient's medical history and treatment plan.

The brain is the central organ of the nervous system, responsible for receiving and processing sensory information, regulating vital functions, and controlling behavior, movement, and cognition. It is divided into several distinct regions, each with specific functions:

1. Cerebrum: The largest part of the brain, responsible for higher cognitive functions such as thinking, learning, memory, language, and perception. It is divided into two hemispheres, each controlling the opposite side of the body.
2. Cerebellum: Located at the back of the brain, it is responsible for coordinating muscle movements, maintaining balance, and fine-tuning motor skills.
3. Brainstem: Connects the cerebrum and cerebellum to the spinal cord, controlling vital functions such as breathing, heart rate, and blood pressure. It also serves as a relay center for sensory information and motor commands between the brain and the rest of the body.
4. Diencephalon: A region that includes the thalamus (a major sensory relay station) and hypothalamus (regulates hormones, temperature, hunger, thirst, and sleep).
5. Limbic system: A group of structures involved in emotional processing, memory formation, and motivation, including the hippocampus, amygdala, and cingulate gyrus.

The brain is composed of billions of interconnected neurons that communicate through electrical and chemical signals. It is protected by the skull and surrounded by three layers of membranes called meninges, as well as cerebrospinal fluid that provides cushioning and nutrients.

Medical Definition:

Magnetic Resonance Imaging (MRI) is a non-invasive diagnostic imaging technique that uses a strong magnetic field and radio waves to create detailed cross-sectional or three-dimensional images of the internal structures of the body. The patient lies within a large, cylindrical magnet, and the scanner detects changes in the direction of the magnetic field caused by protons in the body. These changes are then converted into detailed images that help medical professionals to diagnose and monitor various medical conditions, such as tumors, injuries, or diseases affecting the brain, spinal cord, heart, blood vessels, joints, and other internal organs. MRI does not use radiation like computed tomography (CT) scans.

A mutation is a permanent change in the DNA sequence of an organism's genome. Mutations can occur spontaneously or be caused by environmental factors such as exposure to radiation, chemicals, or viruses. They may have various effects on the organism, ranging from benign to harmful, depending on where they occur and whether they alter the function of essential proteins. In some cases, mutations can increase an individual's susceptibility to certain diseases or disorders, while in others, they may confer a survival advantage. Mutations are the driving force behind evolution, as they introduce new genetic variability into populations, which can then be acted upon by natural selection.

Pseudotumor cerebri, also known as idiopathic intracranial hypertension, is a condition characterized by increased pressure around the brain without any identifiable cause such as a tumor or other space-occupying lesion. The symptoms mimic those of a brain mass, hence the term "pseudotumor."

The primary manifestation of this condition is headaches, often accompanied by vision changes like blurry vision, double vision, or temporary loss of vision, and pulsatile tinnitus (a rhythmic whooshing sound in the ears). Other symptoms can include neck pain, nausea, vomiting, and papilledema (swelling of the optic nerve disc). If left untreated, pseudotumor cerebri can lead to permanent vision loss.

The exact cause of pseudotumor cerebri remains unknown, but it has been associated with certain factors such as obesity, rapid weight gain, female gender (particularly during reproductive years), sleep apnea, and the use of certain medications like tetracyclines, vitamin A derivatives, and steroid withdrawal. Diagnosis typically involves a series of tests including neurological examination, imaging studies (such as MRI or CT scan), and lumbar puncture to measure cerebrospinal fluid pressure. Treatment usually focuses on lowering intracranial pressure through medications, weight loss, and sometimes surgical interventions like optic nerve sheath fenestration or shunting procedures.

An encyclopedia is a comprehensive reference work containing articles on various topics, usually arranged in alphabetical order. In the context of medicine, a medical encyclopedia is a collection of articles that provide information about a wide range of medical topics, including diseases and conditions, treatments, tests, procedures, and anatomy and physiology. Medical encyclopedias may be published in print or electronic formats and are often used as a starting point for researching medical topics. They can provide reliable and accurate information on medical subjects, making them useful resources for healthcare professionals, students, and patients alike. Some well-known examples of medical encyclopedias include the Merck Manual and the Stedman's Medical Dictionary.

Intracranial hypertension is a medical condition characterized by an increased pressure within the skull (intracranial space) that contains the brain, cerebrospinal fluid (CSF), and blood. Normally, the pressure inside the skull is carefully regulated to maintain a balance between the formation and absorption of CSF. However, when the production of CSF exceeds its absorption or when there is an obstruction in the flow of CSF, the pressure inside the skull can rise, leading to intracranial hypertension.

The symptoms of intracranial hypertension may include severe headaches, nausea, vomiting, visual disturbances such as blurred vision or double vision, and papilledema (swelling of the optic nerve disc). In some cases, intracranial hypertension can lead to serious complications such as vision loss, brain herniation, and even death if left untreated.

Intracranial hypertension can be idiopathic, meaning that there is no identifiable cause, or secondary to other underlying medical conditions such as brain tumors, meningitis, hydrocephalus, or certain medications. The diagnosis of intracranial hypertension typically involves a combination of clinical evaluation, imaging studies (such as MRI or CT scans), and lumbar puncture to measure the pressure inside the skull and assess the CSF composition. Treatment options may include medications to reduce CSF production, surgery to relieve pressure on the brain, or shunting procedures to drain excess CSF from the intracranial space.

Wikimedia Commons has media related to Alexander disease. OMIM entries on Alexander disease Infantile-onset Alexander disease ... alexander_disease at NINDS "Cause of brain disease found". January 2, 2001 - via news.bbc.co.uk. "Alexander Disease - United ... It is even possible to detect adult-onset Alexander disease with MRI. Alexander disease may also be revealed by genetic testing ... Alexander disease belongs to leukodystrophies, a group of diseases that affect the growth or development of the myelin sheath. ...
CYP11B1 Alexander disease; 203450; GFAP Alexander disease; 203450; NDUFV1 Alkaptonuria; 203500; HGD Allan-Herndon-Dudley ... RNF212 Refsum disease; 266500; PEX7 Refsum disease; 266500; PHYH Refsum disease, infantile form; 266510; PEX26 Refsum disease, ... PSEN1 Alzheimer disease-10; 104300; AD10 Alzheimer disease-2; 104310; APOE Alzheimer disease-4; 606889; PSEN2 Alzheimer disease ... RLBP1 Niemann-Pick disease, type A; 257200; SMPD1 Niemann-Pick disease, type B; 607616; SMPD1 Niemann-Pick disease, type C1; ...
Robyn Alexander. "Addison's Disease or Hypoadrenocorticism". Scwtca.org. Retrieved 15 April 2017. "SCWTDB.org , Soft Coated ... Other Wheaten health issues are renal dysplasia, inflammatory bowel disease, Addison's disease, and cancer. Some Wheatens can ... Robyn Alexander. "History of the Breed − Soft Coated Wheaten Terrier Club of America". Scwtca.org. Retrieved 11 December 2017. ... Robyn Alexander. "Soft Coated Wheaten Terrier Club of America - Wheaten Health". Swctca.org. Retrieved 11 December 2017. ...
Nicole Alexander-Scott - infectious disease specialist. Judith S. Stern - Member of the National Academy of Medicine, co- ... Mandy Cohen - physician and Director of the U.S. Centers for Disease Control and Prevention Sandra Fluke - attorney, political ...
"Occupational Health Guideline for Ozone" (PDF). Centers for Disease Control and Prevention. Alexander, D. D.; Bailey, W. H.; ... In 1918 Alexander Chizhevsky created the first air ioniser for ion therapy. It was originally used for animal health in ... Perez, V; Alexander, DD; Bailey, WH (15 January 2013). "Air ions and mood outcomes: a review and meta-analysis". BMC Psychiatry ...
Krabbe disease, Canavan disease, and Alexander disease. The one exception to this is any type of leukodystrophy carried on a ... Alexander disease (E75.2) Canavan disease (E75.2) Hypomyelinating leukodystrophy type 7 (4H syndrome) (E75.2) Krabbe disease ( ... Canavan disease, and (5) Alexander disease. Each type of leukodystrophy has a unique pathophysiology, but all five of these in ... Canavan disease is a less-studied type of leukodystrophy that, like MLD and Krabbe disease, is also inherited in an autosomal ...
Quinlan RA, Brenner M, Goldman JE, Messing A (June 2007). "GFAP and its role in Alexander disease". Experimental Cell Research ... The proteinopathies include such diseases as Creutzfeldt-Jakob disease and other prion diseases, Alzheimer's disease, ... Amyloidosis Prion-Related Diseases Protein Misfolding Diseases Book (Articles with short description, Short description is ... For example, in Alzheimer's disease, researchers are seeking ways to reduce the production of the disease-associated protein Aβ ...
Alexander (2008). Poultry Diseases (6th ed.). Elsevier. pp. 317. ISBN 978-0-7020-28625. Ali A, Avalos RT, Ponimaskin E, Nayak ... "Types of Influenza Viruses". Influenza (Flu). Centers for Disease Control and Prevention. November 2, 2021. Archived from the ...
Pattison; McMullin; Bradbury; Alexander (2008). Poultry Diseases (6th ed.). Elsevier. pp. 317. ISBN 978-0-7020-28625. "Types of ... Influenza Viruses". Influenza (Flu). Centers for Disease Control and Prevention. November 2, 2021. Archived from the original ...
Pattison, Mark; McMullin, Paul; PhD, Paul; Alexander, Dennis (2007). Poultry Diseases. Elsevier Health Sciences. ISBN ...
Alexander Gibson. Founder, Challenging Motor Neurone Disease. For services to Charity, particularly to People with Motor ... Volunteer, Northern Ireland Rare Diseases Partnership. For services to People with Rare Diseases in Northern Ireland. Kingsley ... Rupert Alexander Gavin. For services to Drama, the Arts, to Heritage and to the Economy. Professor Iain Gilmour Gray CBE FRSE ... Brigadier Neil Alexander Crerar Baverstock, OBE. Yeoman Usher, House of Lords. For services to Parliament and to the State ...
Bettinardi-Angres K, Angres DH (July 2010). Alexander M (ed.). "Understanding the Disease of Addiction". Journal of Nursing ... When associated with disease, these only confer a small amount of additional risk with an odds ratio of 1.1-1.3 percent; this ... It sends a strong message to the public that American medicine is committed to providing expert care for this disease and ... In May 2019, the WHO introduced gaming disorder in the 11th edition of the International Classification of Diseases. Video game ...
Julie Alexander, 64, British model and actress, Alzheimer's disease. Horace Hahn, 87, American actor. Peter Guy Ottewill, 87, ... Joan Franks Williams, 72, American composer, complications from Parkinson's disease. ...
Alexander was president of the Infectious Diseases Society of America. "Barbara Dudley Alexander , Duke Department of Medicine ... Barbara Dudley Alexander is an American infectious disease physician. She is a professor of medicine and pathology at the Duke ... Alexander earned an M.D. at ECU Brody School of Medicine in 1993. She completed a residency in medicine at Duke University. She ... American infectious disease physicians, 21st-century American women physicians, 21st-century American physicians, American ...
... see Alexander disease). Dame Ingrid Allen, Northern Irish neuropathologist. Friedrich August von Ammon (1799-1861), German ... Alexander A. Maximow (1874-1928), Russian-American scientist, histologist and embryologist. John McCrae (1872-1918), Canadian ... William Boog Leishman (1865-1926), English authority on the pathology of human parasitic diseases (see leishmaniasis) George ... Franz Best (1878-1920), German pathologist (see Best's disease). Xavier Bichat (1771-1802), French anatomist and physiologist, ...
... disease; however, this terminology is no longer used by ophthalmologists. Sanders suffered from Parkinson's disease towards the ... Sanders would also administer MNT treatment on test subjects in Havana as a possible remedy for polio. Sanders was one of the ... cite web}}: Missing or empty ,title= (help) "Sanders disease". TheFreeDictionary.com. Retrieved 2022-09-22. (CS1 errors: ... Furthermore, Sanders was urged by MacArthur to "keep quiet" about any human experiments. Following the acquittal, Sanders ...
Kapu Rajaiah, 87, Indian painter, complication of Parkinson's disease. Alexander Saxton, 93, American novelist and historian. ... Cullen, Sandy; Worland, Gayle (31 August 2012). "Former U.S. District Judge Shabaz dies at 81". Wisconsin State Journal. ... Neville Alexander, 75, South African revolutionary and linguist, cancer. Aurora Bautista, 86, Spanish film actress. Malcolm ... Carl Davis, 77, American record producer ("Duke of Earl", "(Your Love Keeps Lifting Me) Higher and Higher"), lung disease. Tom ...
GeneReviews/NCBI/NIH/UW entry on Alexander disease OMIM entries on Alexander disease Glial Fibrillary Acidic Protein at the U.S ... "Alexander Disease". Medical College of Wisconsin. Hagemann TL, Connor JX, Messing A (October 2006). "Alexander disease- ... Chen YS, Lim SC, Chen MH, Quinlan RA, Perng MD (October 2011). "Alexander disease causing mutations in the C-terminal domain of ... GFAP therefore plays an important role in the pathogenesis of Alexander disease. Notably, the expression of some GFAP isoforms ...
For voluntary service to People with Coronary Heart Disease. Alexander Gill. For services to the fishing community in Kingston- ... Alexander Crombie, Group Chief Executive, Standard Life. For services to the Insurance Industry in Scotland. Dr. Andrew Cubie, ... Professor Alan Alexander Paterson, Professor of Law, Strathclyde University. For services to Legal Education and to Law. Adam ... David Alexander James Hepworth, Q.G.M., lately Senior Investigations Adviser, British Embassy, Kabul. For services to the ...
Parasitic diseases: Turkey coccidiosis". In Pattison, M; McMullin, PF; Bradbury, JM; Alexander, DJ (eds.). Poultry diseases ( ... The parasite causes disease in the cecum, where, on post-mortem examination (necropsy), a cream-colored exudate is seen. EM, ... Eimeria meleagridis is a species of coccidia found worldwide, which causes mild disease in young turkeys aged 4-8 weeks. ... Diseases of poultry (12th ed.). Ames, Iowa: Blackwell Publishing. p. 1082. ISBN 978-0-8138-0718-8. v t e (CS1 maint: multiple ...
Yvette Cauchois, 90, French physicist, infectious disease. Alexander Liberman, 87, Russian-American publisher, painter, ... "Alexander Liberman - Social Networks and Archival Context". snaccooperative.org. Retrieved March 5, 2023. "John McCue". ... Don Harris, 61, American blues and rock and roll violinist and guitarist, pulmonary disease. Huang Hsin-chieh, 71, Taiwanese ... Herbert Freudenberger, 73, German-American psychologist, kidney disease. Kaoru Iwamoto, 97, Japanese Go player and writer. Bill ...
Alexander Skvortsov, 65, Russian ice hockey player, Olympic champion (1984). Fernando Suarez, 52, Filipino Roman Catholic ... Taty Sumirah, 68, Indonesian badminton player, 1975 Uber Cup winner, lung disease. Jimmy Thunder, 54, Samoan-born New Zealand ... Wichie Torres, 67, Puerto Rican painter, cardiovascular disease. Grazia Volpi, 78, Italian film producer (Caesar Must Die, ... Henry Akin, 75, American basketball player (New York Knicks, Seattle SuperSonics, Kentucky Colonels). Duane Alexander, 79, ...
Mercer, Alexander (2014), Infections, Chronic Disease, and the Epidemiological Transition. A New Perspective, Rochester, NY: ... Such a transition can account for the replacement of infectious diseases by chronic diseases over time due to increased life ... With fewer people dying from infectious diseases, there is a rising prevalence of chronic and/or degenerative diseases in the ... The global burden of disease website provides visual comparisons of the disease burdens of countries and the changes over time ...
For services to the Prevention and Treatment of Heart Disease. Michael Alexander Frederik Des Tombe. Deputy Director, ... Sally Alexander. Headteacher and Proprietor, Kimichi School, Birmingham. For services to Education. Dr. John Alexander. ... Professor, Infectious Disease Epidemiology, Imperial College London. For services to Infectious Disease Control and ... Director, Centre of Excellence in Infectious Disease Research. For services to Infectious Diseases Research during the Covid-19 ...
Alexander Skene, MD - authority on women's diseases; discovered the paraurethral glands known as Skene's gland or Skene's ducts ... Alzheimer's Disease Research Program Brooklyn Center for Health Disparities Center for Biomedical Imaging Center for ... and Alzheimer's disease; Adult/pediatric emergency services: the ER receives more than 68,906 patient visits a year [2010 data ...
Katz, Jay; Capron, Alexander Morgan (1975). Catastrophic Diseases: Who Decides What?, p. 35-36 Simmons, John G. (2002). Doctors ... It is a life support treatment and does not treat disease. On 12 December 1957, Kolff implanted an artificial heart into a dog ... Sandy; Nunnally, Sara (2011). Barbarians of Wealth: Protecting Yourself from Today's Financial Attilas, p. 57-58 Rolland, Gail ...
Gehlen, Heidrun; Inerle, Katharina; Bartel, Alexander; Stöckle, Sabita Diana; Ulrich, Sebastian; Briese, Beatrice; Straubinger ... "Lyme disease rashes and look-alikes". Lyme Disease. Centers for Disease Control and Prevention. 21 December 2018. Archived from ... "Lyme Disease Data and surveillance". Lyme Disease. Centers for Disease Control and Prevention. 5 February 2019. Archived from ... Dogs may also experience chronic joint disease if the disease is left untreated. However, the majority of cases of Lyme disease ...
van Rhee, Frits; Voorhees, Peter; Dispenzieri, Angela; Fosså, Alexander; Srkalovic, Gordan; Ide, Makoto; Munshi, Nikhil; Schey ... Castleman disease is named after Benjamin Castleman, who first described the disease in 1956. The Castleman Disease ... Whether Castleman disease should be considered an autoimmune disease, cancer, or infectious disease is currently unknown. ... Diseases other than Castleman disease can present with similar histologic findings in lymph node tissue, including: Infectious ...
William Alexander; Helaine Bader; Judith H. LaRosa (2011). New Dimensions in Women's Health. Jones & Bartlett Publishers. p. ... A vaginal disease is a pathological condition that affects part or all of the vagina. Sexually transmitted disease that affect ... In the developing world, a group of parasitic diseases also cause vaginal ulceration, such as leishmaniasis, but these are ... All of the aforementioned local vulvovaginal diseases are easily treated. Often, only shame prevents patients from presenting ...
Alexander; Denora, Paola; Fernandez, José; Elleuch, Nizar (April 2008). "Identification of the SPG15 gene, encoding spastizin, ... "Spastic paraplegia 15 - About the Disease - Genetic and Rare Diseases Information Center". rarediseases.info.nih.gov. Retrieved ... The disease also affects the upper limbs, and includes additional symptoms, which makes this type of HSP a complicated type ( ... The disease is characterised by progressive spasticity that starts within the lower extremities and spreads to the upper body ...
Wikimedia Commons has media related to Alexander disease. OMIM entries on Alexander disease Infantile-onset Alexander disease ... alexander_disease at NINDS "Cause of brain disease found". January 2, 2001 - via news.bbc.co.uk. "Alexander Disease - United ... It is even possible to detect adult-onset Alexander disease with MRI. Alexander disease may also be revealed by genetic testing ... Alexander disease belongs to leukodystrophies, a group of diseases that affect the growth or development of the myelin sheath. ...
Alexander disease is a rare disorder of the nervous system. Explore symptoms, inheritance, genetics of this condition. ... medlineplus.gov/genetics/condition/alexander-disease/ Alexander disease. ... Zang L, Wang J, Jiang Y, Gu Q, Gao Z, Yang Y, Xiao J, Wu Y. Follow-up study of 22 Chinese children with Alexander disease and ... Alexander disease is a rare disorder of the nervous system. It is one of a group of disorders, called leukodystrophies, that ...
We report on a family with dominantly inherited asymptomatic Alexanders disease due to a novel Glial fibrillary acidic protein ... Asymptomatic hereditary Alexanders disease caused by a novel mutation in GFAP J Neurol Sci. 2004 Oct 15;225(1-2):125-7. doi: ... These results suggest the existence of a forme fruste of Alexanders disease. The L331P mutation may be associated with the ... mild phenotype of Alexanders disease. To elucidate the genotype-phenotype correlation in Alexanders disease, molecular ...
Identification of a novel de novo pathogenic variant in GFAP in an Iranian family with Alexander disease by whole-exome ... Alexander Disease Research Update. Alexander Disease Research Update - Episode #14: whole exome/genome sequencing; more ... Alexander Disease Research Update. Alexander Disease Research Update - Episode #14: whole exome/genome sequencing; more ... Help support research on Alexander Disease at the University of Wisconsin-Madisons Waisman Center:. https://alexander-disease. ...
Mahy B. In Memoriam: Alexander I. Klimov (1943-2013). Emerging Infectious Diseases. 2013;19(5):842. doi:10.3201/eid1905.im0266. ... Brian W. J. Mahy, Emerging Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, Mailstop D61, ... The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. ... Mahy, B. (2013). In Memoriam: Alexander I. Klimov (1943-2013). Emerging Infectious Diseases, 19(5), 842. https://doi.org/ ...
Alexander Technique and Parkinsons Disease - Training Day 1. on 11/02/2018. ... She teaches at The Bloomsbury Alexander Centre in Holborn and at The Alexander Technique Studio in Wandsworth Common. A keen ... Programme for Alexander Technique Teachers 2018. An opportunity for six teachers to receive free practical experience in ... Loretta values the Alexander Technique as a constructive approach to managing our individual limitations and living as fully, ...
It is feasible that the major title of the record Alexander Disease is not the name you anticipated. ... Alexander Disease. Essential. It is feasible that the major title of the record Alexander Disease is not the name you ... Alexander condition has actually traditionally been consisted of amongst the leukodystrophies- conditions of the white concern ... Appropriately, it is much more suitable to think about Alexander condition an illness of astrocytes (an astrogliopathy) ...
Contact Eye 1st Vision Center in Sandy Springs, GA at (404) 800-3705 for more info. ... We manage a wide array of eye diseases to ensure your total eye health. ... Eye Disease Management Seniors are susceptible to a number of eye diseases that can impair their vision. Many of these diseases ... See Our Sandy Springs, GA, Eye Care Specialist for Eye Disease Management ...
Disease. Alec Cabacungan is suffering from Osteogenesis Imperfecta, which is also known as Brittle bone disease. Alec suffered ... The disease is quite rare among children as only 20% of people in the world suffer from such disease. When Alec was just 12 ... Alec Cabacungan Wiki 2022: Net Worth, Disease, Wife and Full Bio. By StarIdolAdmin / March 6, 2024 ... From the outside, Alec has a short height and normal weight, which could also be because of his disease, which prevents growth. ...
This fact sheet provides information about Alexander disease, a rare disorder of the nervous system caused by the mutation of ... This fact sheet provides information about Krabbe disease, its frequency, signs and symptoms,and types. ...
Light sandy, Special conditions: Tolerate air pollution, Facing: South - Delivery by Waitrose Garden ... Resistant to diseases, Attractive to wildlife: Attractive to pollinators, Soil type: ...
The Celiac Disease Foundation Healthcare Practitioner Directory is a free listing of physicians, dietitians, mental health ... professionals and allied health providers in all 50 states, who treat patients with celiac disease. ... 1998-2024 Celiac Disease Foundation. The Celiac Disease Foundation is a recognized 501(c)(3) nonprofit organization. All ... Alexander Shikhman MD. *Rheumatology. *Internal Medicine. ... About Celiac Disease. About the Disease *What is Celiac Disease ...
Bonatus TJ, Alexander AH. Dercums disease (adiposis dolorosa). A case report and review of the literature. Clin Orthop Relat ... Adiposis dolorosa (Dercums disease): liposuction as an effective form of treatment. Plast Reconstr Surg. 1990 Feb. 85(2):289- ... Reggiani M, Errani A, Staffa M, Schianchi S. Is EMLA effective in Dercums disease?. Acta Derm Venereol. 1996 Mar. 76(2):170-1 ... Brodovsky S, Westreich M, Leibowitz A, Schwartz Y. Adiposis dolorosa (Dercums disease): 10-year follow-up. Ann Plast Surg. ...
A simple toolkit developed can help improve the outcomes of heart attacks and other cardiovascular diseases among patients in ... Coronary Artery Disease Spiked by 300% in India: Cardiologist Thomas Alexander. Coronary artery disease has spiked by 300% ... Coronary Heart Disease In coronary heart disease, blood is unable to flow through blocked arteries. The main symptom is chest ... Medindia » News » Heart Disease News » New Toolkit Helps Improve Heart Attack Care in Indian Hospitals ...
... of cardiomyopathy have been put forward that differ somewhat with these long-standing categorizations of heart disease. ... Cardiomyopathy simply means heart muscle disease. [1] It can occur as a primary affliction of the heart muscle, from a ... Aaseth J, Alexander J, Alehagen (2021) Coenzyme Q10 supplementation-in ageing and disease. Mechanisms of Ageing and Development ... Brain disorders, including Parkinsons disease and Alzheimers disease, stroke, and depression [149-152] ...
Echocardiography, Cardiovascular Disease Research Interests My research interests include 1) The cost-effectiveness of new ... Alexander C. Perino MD is a cardiac electrophysiologist, clinical informaticist, and cardiovascular researcher. In his clinical ... 2) Interventions to improve the quality of care of patients with heart disease. Examples: include clinical reminders and home ... Board Certification: American Board of Internal Medicine, Cardiovascular Disease (2019) * Board Certification: American Board ...
Joann Alexanders Groups. * Diseases - old & recent. 14 members. 21 Comments 0 Likes ... Foreman, Alexander, Williams, Warren, Youngblood, Craft, Overby, Collins, Yancey, Rasberry, Welch, Sumrall, Womble, Cook. What ...
Alexander; Edward L. Baker Jr. ... A81: Chronic Disease Prevention and Control: Coming of Age at ... Centers for Disease Control and Prevention. National Center for Chronic Disease Prevention and Health Promotion. United States ...
Prayers for Karls disease. Prayers for Sandy. LORD, they are struggling with illness that only you Father can heal. In Jesus ...
Some thoughts on the Cost Disease. Saturday 18 February 2017, 06:40 The lovely and talented Scott Alexander has a posting on ... Cost Disease: the costs of some things, notably education and medical care especially in the USA, have increased in the last ...
A Sanders California campaign spokeswoman Anna Bahr says the poll results show their work the past nine months is paying off. ... Sanders rose to 27% support... followed by Biden at 24%, Warren at 23%, Buttigieg with 6%, and Klobuchar at 4%. Andrew Yang had ... Warren put out a statement on Monday, however, saying that Sanders told her during a 2018 meeting that he did not think a woman ... Warren wrote, I thought a woman could win; he disagreed. She also noted in the statement that she and Sanders were allies and ...
Senator Sanders proposes major cuts to Israeli military aid amid human rights concerns. Alexis Sterling - April 23, 2024. ... Air pollution now linked to degenerative eye disease and mental health.... Alexandra Jacobo - August 24, 2019. ... Amid accusations of genocide and widespread human rights abuses, Senator Bernie Sanders champions amendments to halt offensive ...
Fort Sanders Regional Medical Center /. Fort Sanders Regional Services /. Digestive Disease Center / ... Gastroesophageal Reflux Disease (GERD) A condition in which acid-containing contents in your stomach persistently leak back up ... Twenty-four-hour pH impedance testing can be used to check for gastroesophageal reflux disease (GERD), a problem with stomach ... I would like a Covenant Health representative to contact me regarding treatment options for digestive disease at the phone ...
Best Periodontal diseases dentists in Poland . Authentic patient reviews of doctors in MedReviews. ... Best Periodontal diseases dentists worldwide. Dr. Alexander Zalesski. Dentists in Hurth. Dentists ... Best Periodontal diseases dentists in Poland Found 0 Periodontal diseases dentists in Poland ... due to a shortage of Periodontal diseases dentists in Poland or due to a mismatch of Periodontal diseases dentists with my ...
Alexander LT, *et al. . Physical activity and risk of breast cancer, colon cancer, diabetes, ischemic heart disease, and ... Follow-up for dementia, Alzheimers disease, and cardiometabolic disease. Data on dementia status at follow-up was extracted ... coronary heart disease, and stroke in a subgroup of participants who were alive and free of these diseases at age 65. To assess ... coronary heart disease, and stroke during the first 10 years of follow-up and from year 10 onwards in those without the disease ...
The Act requires owners of diseased animals to keep them separate from other animals and to notify the disease to the inspector ... This Act introduces certain measures for the control and eradication of diseases affecting all kinds of animals, except poultry ... Animal (Diseases and Importation) Act (No. 31 of 1953).. País/Territorio. Antigua y Barbuda. Tipo de documento. Legislación. ... Delete record "Animal (Diseases and Importation) Act (No. 31 of 1953).". You really want to delete this record? Once the record ...
Identify and treat common hydrangea pest problems and diseases with this guide from HGTV. ... Guide to Hydrangea Diseases and Pests Do your hydrangeas leaves have brown spots or holes? Stop hydrangea pests and diseases ... This fungal disease looks like round, orangish spots on the underside of hydrangea leaves. The tops of leaves turn brown or ... While this disease doesnt usually kill hydrangeas, it can cause their leaves to drop. Its characterized by a pale gray, ...
Research suggests that ADHD and Alzheimers disease, a form of dementia, may share genetic pathways, but one doesnt cause the ... Medically reviewed by Alexander Klein, PsyD. There is still not much know about the cause of ADHD, but some have linked the ... Living with ADHD may increase the chance of developing other diseases, which may in turn increase the chance of experiencing ... For example, in Alzheimers disease - a form of dementia - protein accumulation outside of brain cells can affect cellular ...
Disease interplay reflects that microbial infections and consequent inflammation affects neurodegenerative diseases and vice ... and limited drug-targeting to disease-affected tissue. Improving upon these properties can be accomplished by a prodrug design ... Alexander, G.C.; Karlawish, J. The Problem of Aducanumab for the Treatment of Alzheimer Disease. Ann. Intern. Med. 2021, 174, ... Neurodegenerative diseases include but are not limited to, AD, PD, ALS, Huntingtons disease (HD), and infections of the ...
Chronic Kidney Disease - from Pathophysiology to Clinical Improvements. Edited by: Thomas Rath. ISBN 978-953-51-3843-3, eISBN ... By Luís Manuel Mota de Sousa, Ana Vanessa Antunes, Cristina Rosa Soares Lavareda Baixinho, Sandy Silva Pedro Severino, Cristina ... 5. Cardiovascular Aspects of Patients with Chronic Kidney Disease and End-Stage Renal Disease By Ali Osama Malik, Sumit Sehgal ... Known worldwide, chronic kidney disease (CKD) is a disease that affects up to 4% of the population with increasing figures also ...
  • ADHD and Alzheimer's Disease: Is There a Connection? (psychcentral.com)
  • For example, in Alzheimer's disease - a form of dementia - protein accumulation outside of brain cells can affect cellular health and function. (psychcentral.com)
  • A 2021 multigenerational study found that parents of a child living with ADHD have a 34% higher chance of developing dementia and a 55% higher chance of developing Alzheimer's disease, specifically. (psychcentral.com)
  • Only a small fraction of older adults in the early stages of Alzheimer's disease (AD) meet eligibility criteria to receive treatment with newly approved anti-amyloid drugs, largely due to the presence of medical conditions or neuroimaging findings, new research shows. (medscape.com)
  • 2022 Alzheimer's Disease Facts and Figures. (msdmanuals.com)
  • Inverse relationship between education and parietotemporal perfusion deficit in Alzheimer's disease. (bvsalud.org)
  • As of 2022, Alec Cabacungan has a net worth of approximately $1 million. (staridolchoice.com)
  • Centers for Disease Control and Prevention. (cdc.gov)
  • Dr Klimov began his career at the Centers for Disease Control and Prevention (CDC), Atlanta, Georgia, USA, following a career of great distinction at the Research Institute for Viral Preparations in Moscow, Russia, where in 1986 he became director of the World Health Organization (WHO) Collaborating Center for Molecular Biology and Genetics of Epidemic and Vaccine Influenza Virus Strains and head of the Laboratory of Genetics of RNA Viruses. (cdc.gov)
  • The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. (cdc.gov)
  • PATCH, the acronym for Planned Approach to Community Health, is a cooperative program of technical assistance managed and supported by the Centers for Disease Control (CDC). (cdc.gov)
  • The Centers for Disease Control and Prevention (CDC) has recently updated COVID-19 quarantine and isolation recommendations for healthcare and non-healthcare settings. (cdc.gov)
  • The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. (cdc.gov)
  • The meeting was also attended by representatives of Rotary International and the Centers for Disease Control and Prevention (CDC), Atlanta, and staff from WHO headquarters, regional offices for Africa, South-East Asia and the Eastern Mediterranean and the WHO Somalia office. (who.int)
  • Former Vice-President Joe Biden, former South Bend, Indiana Mayor Pete Buttigieg, Minnesota Senator Amy Klobuchar, Vermont Senator Bernie Sanders, billionaire philanthropist Tom Steyer, and Massachusetts Senator Elizabeth Warren all met the criteria for number of donors and poll numbers in early primary states. (ktvu.com)
  • Amid accusations of genocide and widespread human rights abuses, Senator Bernie Sanders champions amendments to halt offensive military funding to Israel, sparking a critical Senate debate. (nationofchange.org)
  • Alexander disease is a genetic disorder affecting the midbrain and cerebellum of the central nervous system. (wikipedia.org)
  • Alexander disease may also be revealed by genetic testing for its known cause. (wikipedia.org)
  • In addition, chapters dealing with genetic aspects of polycystic kidney disease and also the clinical handling of patients with CKD and peritoneal dialysis will be beneficial for the open-minded reader. (intechopen.com)
  • CCLHO will conduct the March Chronic Disease and Injury Prevention Committee meeting in person and through WebEx. (ca.gov)
  • You may attend the CCLHO Chronic Disease and Injury Prevention Committee meeting in person, teleconference or via WebEx. (ca.gov)
  • Alexander disease is a very rare autosomal dominant leukodystrophy, which are neurological conditions caused by anomalies in the myelin which protects nerve fibers in the brain. (wikipedia.org)
  • It is inherited in an autosomal dominant manner, such that the child of a parent with the disease has a 50% chance of inheriting the condition, if the parent is heterozygotic. (wikipedia.org)
  • Mutations in genes for the amyloid precursor protein, presenilin I, and presenilin II may lead to autosomal dominant forms of Alzheimer disease, typically with early onset. (msdmanuals.com)
  • Sexually transmitted diseases / A. McMillan, G. R. Scott. (who.int)
  • Immunological diagnosis of sexually transmitted diseases / edited by Hugh Young, Alexander McMillan. (who.int)
  • The disease occurs in both males and females, and no ethnic, racial, geographic or cultural/economic differences are seen in its distribution. (wikipedia.org)
  • Usually, the later the disease occurs, the slower its course. (wikipedia.org)
  • Rarely, a neonatal form of Alexander disease occurs within the first month of life and is associated with severe intellectual disability and developmental delay, a buildup of fluid in the brain (hydrocephalus), and seizures. (medlineplus.gov)
  • Furthermore, heart failure rarely occurs by itself without other diseases and co-morbid conditions being present and contributing to symptoms as well. (positivehealth.com)
  • Instead, by developing models in the dish with high biological relevance and predictive value for the human brain, we can accelerate our knowledge about what occurs during diseases affecting humans. (lu.se)
  • The cause of Alexander disease is a mutation in the gene encoding GFAP. (wikipedia.org)
  • We report on a family with dominantly inherited asymptomatic Alexander's disease due to a novel Glial fibrillary acidic protein (GFAP) mutation. (nih.gov)
  • This fact sheet provides information about Alexander disease, a rare disorder of the nervous system caused by the mutation of the GFAP gene. (ideas.org.au)
  • In 1997, he became chief of the branch's Surveillance Section, and in 2006, after a reorganization of CDC, he became chief of the Surveillance and Diagnosis Branch within the newly formed Influenza Division, National Center for Immunization and Respiratory Diseases. (cdc.gov)
  • Adult-onset forms of Alexander disease are less common. (wikipedia.org)
  • Common problems in juvenile and adult forms of Alexander disease include speech abnormalities, swallowing difficulties, seizures, and poor coordination (ataxia). (medlineplus.gov)
  • The symptoms sometimes mimic those of Parkinson's disease or multiple sclerosis, or may present primarily as a psychiatric disorder. (wikipedia.org)
  • Following on from previous workshops and activities The Walter Carrington Educational Trust is offering six STAT qualified teachers to participate in two workshops and the opportunity to give 10 lessons to a person with Parkinson's Disease. (constructiveteachingcentre.com)
  • This training will consist of attending two sponsored Alexander Technique workshops, where special training will be given in the mornings, followed by hands-on experience with people living with Parkinson's in the afternoons. (constructiveteachingcentre.com)
  • Attendance on both days and completion of an online questionnaire by the Trust afterwards will be a prerequisite for allocation of a pupil with Parkinson's Disease by the Trust. (constructiveteachingcentre.com)
  • After completion of the two training days each teacher will have the opportunity to have a pupil living with Parkinson's Disease allocated for a series of 10 Alexander Technique lessons. (constructiveteachingcentre.com)
  • Notable exclusions included cardiopulmonary contraindications, central nervous system-related exclusions such as brain cancer, Parkinson's disease, epilepsy or brain injury, imaging findings, and history of cancer. (medscape.com)
  • Cell Replacement Therapy for Parkinson's Disease - Evaluating the potential of autologous grafting. (lu.se)
  • Traditional Japanese vascular disease (CVD), stroke, gastric cancer, osteopo- foods, including soy sauce and dried fish products rosis and renal disease ( 1 ). (who.int)
  • Warren put out a statement on Monday, however, saying that Sanders told her during a 2018 meeting that he did not think a woman could win the presidential election. (ktvu.com)
  • Alexander disease belongs to leukodystrophies, a group of diseases that affect the growth or development of the myelin sheath. (wikipedia.org)
  • As myelin deteriorates in leukodystrophies such as Alexander disease, nervous system functions are impaired. (medlineplus.gov)
  • Gorospe JR, Maletkovic J. Alexander disease and megalencephalic leukoencephalopathy with subcortical cysts: leukodystrophies arising from astrocyte dysfunction. (medlineplus.gov)
  • Alexander condition has actually traditionally been consisted of amongst the leukodystrophies- conditions of the white concern of the human brain. (valleyfamilymedicineurgentcarecenter.com)
  • To elucidate the genotype-phenotype correlation in Alexander's disease, molecular diagnosis and MRI examination are required for many patients and their families. (nih.gov)
  • If you show signs of eye disease, we'll provide you with an accurate diagnosis of your condition so you can get treatment. (eye1stvision.com)
  • It is even possible to detect adult-onset Alexander disease with MRI. (wikipedia.org)
  • These inherited enzyme defects usually present in childhood, although some, such as McArdle disease and Pompe disease, have separate adult-onset forms. (medscape.com)
  • Objective To examine whether physical inactivity is a risk factor for dementia, with attention to the role of cardiometabolic disease in this association and reverse causation bias that arises from changes in physical activity in the preclinical (prodromal) phase of dementia. (bmj.com)
  • Living with ADHD may increase the chance of developing other diseases, which may in turn increase the chance of experiencing dementia. (psychcentral.com)
  • laboratory and imaging tests are usually done to look for specific findings that suggest Alzheimer disease and to identify other treatable causes of dementia. (msdmanuals.com)
  • In cases of early-onset or neonatal Alexander disease, symptoms include seizures, fluid buildup in the brain, high protein levels in cerebrospinal fluid, and severe motor and intellectual impairment. (wikipedia.org)
  • In cases of type I Alexander disease, where the condition appears before age 4, symptoms include seizures, enlarged brain and head, stiffness in the limbs, delayed intellectual and physical development, recurrent vomiting, and difficulties with gaining weight. (wikipedia.org)
  • The Rosenthal fibers found in Alexander disease do not share the distribution or concentration of other diseases and disorders. (wikipedia.org)
  • As a cardiovascular researcher, Dr. Perino uses large datasets to examine quality of care, outcomes, and risk prediction for heart rhythm disorders and cardiovascular disease. (stanford.edu)
  • After beginning her research journey as a master's student within our Ph.D. Preparatory Program, she dedicated the last several years to developing more efficient methods that can be used to generate functional and mature astrocytes for disease modeling of neurological disorders. (lu.se)
  • Appropriately, it is much more suitable to think about Alexander condition an illness of astrocytes (an astrogliopathy) compared to a white concern condition (leukodystrophy). (valleyfamilymedicineurgentcarecenter.com)
  • In this interview, we learn more about her efforts to facilitate future research that explores the role of astrocytes in disease and could lead to the development of new efficient treatments for many diseases affecting the brain. (lu.se)
  • My Ph.D. studies have focused on developing ways to generate human astrocytes from pluripotent stem cells and fibroblasts for modeling diseases affecting the human brain. (lu.se)
  • A survey released Monday by the Public Policy Institute of California shows Sanders taking a lead among California primary voters. (ktvu.com)
  • A Sanders California campaign spokeswoman Anna Bahr says the poll results show their work the past nine months is paying off. (ktvu.com)
  • We focused on one of the main cell types found in our brains, the astrocyte, which over the last decade has emerged as an important contributor to a wide range of neurological diseases. (lu.se)
  • The proband, a 16-month-old boy, presented with megalocephaly and brain magnetic resonance imaging (MRI) showing the typical findings of Alexander's disease. (nih.gov)
  • These results suggest the existence of a forme fruste of Alexander's disease. (nih.gov)
  • The L331P mutation may be associated with the mild phenotype of Alexander's disease. (nih.gov)
  • Alzheimer disease causes progressive cognitive deterioration and is characterized by beta-amyloid deposits and neurofibrillary tangles in the cerebral cortex and subcortical gray matter. (msdmanuals.com)
  • In the US, an estimated 10% of people ≥ 65 have Alzheimer disease. (msdmanuals.com)
  • Most cases of Alzheimer disease are sporadic, with late onset ( ≥ 65 years) and unclear etiology. (msdmanuals.com)
  • Risk of Alzheimer disease is substantially increased in people with two epsilon-4 alleles and may be decreased in those who have the epsilon-2 allele. (msdmanuals.com)
  • For people with two epsilon-4 alleles, risk of developing Alzheimer disease by age 75 is about 10 to 30 times that for people without the allele. (msdmanuals.com)
  • Coronary artery disease has spiked by 300% among Indians in the past three decades, with 2-6% of the affected people living in rural India and 2-12% in urban India. (medindia.net)
  • and the secondary outcome was incident cardiometabolic disease (that is, diabetes, coronary heart disease, and stroke). (bmj.com)
  • Promote health improvement, wellness, and disease prevention in cooperation with patients, communities, at-risk populations, and other members of an interprofessional team of health care providers. (cdc.gov)
  • In cases of type II Alexander disease, where the condition appears after the age of 4, symptoms include speech problems, difficulty swallowing, poor coordination, scoliosis, recurrent vomiting, and difficulties with gaining weight. (wikipedia.org)
  • It is not well understood how impaired astroglial cells contribute to the abnormal formation or maintenance of myelin, leading to the signs and symptoms of Alexander disease. (medlineplus.gov)
  • Many of these diseases are incurable and don't show symptoms until their damage is done. (eye1stvision.com)
  • Although there's no cure for this disease, symptoms can be managed with special eye drops, laser therapies, or surgical procedures to slow down or prevent further vision loss. (eye1stvision.com)
  • This fact sheet provides information about Krabbe disease, its frequency, signs and symptoms,and types. (ideas.org.au)
  • excessive citations] A CT scan shows: Decreased density of white matter Frontal lobe predominance Dilated lateral ventricles may present Detecting the signs of Alexander disease is possible with magnetic resonance imaging (MRI), which looks for specific changes in the brain that may be tell-tale signs for the disease. (wikipedia.org)
  • There is extremely limited access to brain tissue for research purposes, both from healthy individuals as well as from patients with brain disease. (lu.se)
  • To describe the epidemiology of selected vaccine-preventable diseases in NSW for 2013. (who.int)
  • If you're interested in finding Periodontal diseases dentists based on specific preferences, you can refine your search by regions in the country, language of service, gender of the doctor, and more. (medreviews.com)
  • To find Periodontal diseases dentists in Poland who speak a specific language, you need to select the desired language in the 'Additional Filters' table - Language and click the 'Search' button. (medreviews.com)
  • To find Periodontal diseases dentists who provide online services (virtual consultations), you need to select the 'Virtual Consultation' checkbox in the 'Additional Filters' table and click the 'Search' button. (medreviews.com)
  • Results of search for 'au:'McMillan, Alexander. (who.int)
  • Moderates such as Biden, Buttigieg and Klobuchar are battling to pull the party to the center, as the progressive wing with Sanders and Warren attempt to lead the Democratic party farther left. (ktvu.com)
  • As the field narrows, Tuesday's debate takes on added importance in a race that has seen Warren, Sanders, Biden and Buttigieg take the lead at various times. (ktvu.com)
  • Dear Librarian, I would like to recommend the following IntechOpen book to be added to our library catalog: TITLE: 'Chronic Kidney Disease - from Pathophysiology to Clinical Improvements' PRINT ISBN: 978-953-51-3843-3 Libraries are offered a 20% discount on retail book prices. (intechopen.com)
  • Dr Klimov came to CDC in 1991 as a visiting scientist in the Influenza Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases. (cdc.gov)
  • and the James H. Nakano Award for an outstanding scientific paper, National Center for Infectious Diseases, CDC, in 1996, 2001, and 2005. (cdc.gov)
  • At Eye 1st Vision Center in Sandy Springs, GA, we can monitor your eye health and vision through annual eye exams. (eye1stvision.com)
  • To schedule a consultation for eye disease management, contact Eye 1st Vision Center in Sandy Springs, GA at (404) 252-1702 . (eye1stvision.com)
  • Our Center of Excellence for Barrett's Esophagus at Fort Sanders Regional is an alliance of medical professionals, research organizations, and supporting services that provide comprehensive and well-coordinated care for patients. (covenanthealth.com)
  • Graff-Radford J, Schwartz K, Gavrilova RH, Lachance DH, Kumar N. Neuroimaging and clinical features in type II (late-onset) Alexander disease. (medlineplus.gov)
  • Dr Klimov was also a regular reviewer of papers submitted to Emerging Infectious Diseases, the Journal of Clinical Virology, the Journal of Virological Methods, Vaccine, Virology, and Virus Research, and he was a member of the editorial board of Voprosy Virusologii (Russia). (cdc.gov)
  • Alexander C. Perino MD is a cardiac electrophysiologist, clinical informaticist, and cardiovascular researcher. (stanford.edu)
  • Clinical practice in sexually transmissible diseases / D. H. H. Robertson, A. McMillan, H. Young. (who.int)
  • Due to his condition, Alec has broken over 60 bones in his body and has to be hospitalized several times however he is a fighter and has been living a happy life despite various difficulties. (staridolchoice.com)
  • Agency for Toxic Substances and Disease Registry. (cdc.gov)
  • If you have diabetes, you're prone to diabetic retinopathy, an incurable eye disease that can damage the retina of your eyes to impair your sight. (eye1stvision.com)
  • Benign symmetric lipomatosis (Madelung's disease). (medscape.com)
  • Alexander disease is a rare disorder of the nervous system. (medlineplus.gov)
  • The juvenile form of Alexander disease has an onset between the ages of 2 and 13 years. (wikipedia.org)
  • As a result, they become dry, irritated, and itchy, making you more prone to eye infections and disease. (eye1stvision.com)
  • Such treatments mostly affect children from a very young age, so Alec is using his fame and experience to convey the message of treatment and message of Osteogenesis Imperfecta. (staridolchoice.com)
  • Air pollution now linked to degenerative eye disease and mental health. (nationofchange.org)
  • He has suffered from very rare brittle bone diseases and has been successful with the treatment. (staridolchoice.com)
  • They also convinced Alec his advertisement will help children suffering from his rare disease and would encourage them to receive treatment. (staridolchoice.com)
  • Although at least 14 unique GSDs are discussed in the literature, the 4 that cause clinically significant muscle weakness are Pompe disease (GSD type II, acid maltase deficiency), Cori disease (GSD type III, debranching enzyme deficiency), McArdle disease (GSD type V, myophosphorylase deficiency), and Tarui disease (GSD type VII, phosphofructokinase deficiency). (medscape.com)
  • To study the role of fat metabolism in GSD type V, Andersen et al manipulated the availability of free fatty acid for oxidation during exercise in 10 patients with the disease. (medscape.com)
  • Alexander disease is also characterized by abnormal protein deposits known as Rosenthal fibers. (medlineplus.gov)
  • Most cases of Alexander disease begin before age 2 and are described as the infantile form. (medlineplus.gov)
  • In this article, you will learn a lot about Alec, his battle with his disease, and how he is proving to be an inspiration to many people worldwide. (staridolchoice.com)