Alexander Disease: Rare leukoencephalopathy with infantile-onset accumulation of Rosenthal fibers in the subpial, periventricular, and subependymal zones of the brain. Rosenthal fibers are GLIAL FIBRILLARY ACIDIC PROTEIN aggregates found in ASTROCYTES. Juvenile- and adult-onset types show progressive atrophy of the lower brainstem instead. De novo mutations in the GFAP gene are associated with the disease with propensity for paternal inheritance.Glial Fibrillary Acidic Protein: An intermediate filament protein found only in glial cells or cells of glial origin. MW 51,000.alpha-Crystallin B Chain: One of the alpha crystallin subunits. In addition to being expressed in the lens (LENS, CRYSTALLINE), alpha-crystallin B chain has been found in a variety of tissues such as HEART; BRAIN; MUSCLE; and KIDNEY. Accumulation of the protein in the brain is associated with NEURODEGENERATIVE DISEASES such as CREUTZFELDT-JAKOB SYNDROME and ALEXANDER DISEASE.Leukodystrophy, Metachromatic: An autosomal recessive metabolic disease caused by a deficiency of CEREBROSIDE-SULFATASE leading to intralysosomal accumulation of cerebroside sulfate (SULFOGLYCOSPHINGOLIPIDS) in the nervous system and other organs. Pathological features include diffuse demyelination, and metachromatically-staining granules in many cell types such as the GLIAL CELLS. There are several allelic and nonallelic forms with a variety of neurological symptoms.Astrocytes: A class of large neuroglial (macroglial) cells in the central nervous system - the largest and most numerous neuroglial cells in the brain and spinal cord. Astrocytes (from "star" cells) are irregularly shaped with many long processes, including those with "end feet" which form the glial (limiting) membrane and directly and indirectly contribute to the BLOOD-BRAIN BARRIER. They regulate the extracellular ionic and chemical environment, and "reactive astrocytes" (along with MICROGLIA) respond to injury.Brain Diseases: Pathologic conditions affecting the BRAIN, which is composed of the intracranial components of the CENTRAL NERVOUS SYSTEM. This includes (but is not limited to) the CEREBRAL CORTEX; intracranial white matter; BASAL GANGLIA; THALAMUS; HYPOTHALAMUS; BRAIN STEM; and CEREBELLUM.Stem Cells: Relatively undifferentiated cells that retain the ability to divide and proliferate throughout postnatal life to provide progenitor cells that can differentiate into specialized cells.Leukodystrophy, Globoid Cell: An autosomal recessive metabolic disorder caused by a deficiency of GALACTOSYLCERAMIDASE leading to intralysosomal accumulation of galactolipids such as GALACTOSYLCERAMIDES and PSYCHOSINE. It is characterized by demyelination associated with large multinucleated globoid cells, predominantly involving the white matter of the central nervous system. The loss of MYELIN disrupts normal conduction of nerve impulses.Mutation: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.Brain: The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.Keratins: A class of fibrous proteins or scleroproteins that represents the principal constituent of EPIDERMIS; HAIR; NAILS; horny tissues, and the organic matrix of tooth ENAMEL. Two major conformational groups have been characterized, alpha-keratin, whose peptide backbone forms a coiled-coil alpha helical structure consisting of TYPE I KERATIN and a TYPE II KERATIN, and beta-keratin, whose backbone forms a zigzag or pleated sheet structure. alpha-Keratins have been classified into at least 20 subtypes. In addition multiple isoforms of subtypes have been found which may be due to GENE DUPLICATION.Intermediate Filament Proteins: Filaments 7-11 nm in diameter found in the cytoplasm of all cells. Many specific proteins belong to this group, e.g., desmin, vimentin, prekeratin, decamin, skeletin, neurofilin, neurofilament protein, and glial fibrillary acid protein.Vimentin: An intermediate filament protein found in most differentiating cells, in cells grown in tissue culture, and in certain fully differentiated cells. Its insolubility suggests that it serves a structural function in the cytoplasm. MW 52,000.Intermediate Filaments: Cytoplasmic filaments intermediate in diameter (about 10 nanometers) between the microfilaments and the microtubules. They may be composed of any of a number of different proteins and form a ring around the cell nucleus.Phenotype: The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.Human Characteristics: The fundamental dispositions and traits of humans. (Merriam-Webster's Collegiate Dictionary, 10th ed)Guilt: Subjective feeling of having committed an error, offense or sin; unpleasant feeling of self-criticism. These result from acts, impulses, or thoughts contrary to one's personal conscience.Encephalopathy, Bovine Spongiform: A transmissible spongiform encephalopathy of cattle associated with abnormal prion proteins in the brain. Affected animals develop excitability and salivation followed by ATAXIA. This disorder has been associated with consumption of SCRAPIE infected ruminant derived protein. This condition may be transmitted to humans, where it is referred to as variant or new variant CREUTZFELDT-JAKOB SYNDROME. (Vet Rec 1998 Jul 25;143(41):101-5)Prions: Small proteinaceous infectious particles which resist inactivation by procedures that modify NUCLEIC ACIDS and contain an abnormal isoform of a cellular protein which is a major and necessary component. The abnormal (scrapie) isoform is PrPSc (PRPSC PROTEINS) and the cellular isoform PrPC (PRPC PROTEINS). The primary amino acid sequence of the two isoforms is identical. Human diseases caused by prions include CREUTZFELDT-JAKOB SYNDROME; GERSTMANN-STRAUSSLER SYNDROME; and INSOMNIA, FATAL FAMILIAL.Folklore: The common orally transmitted traditions, myths, festivals, songs, superstitions, and stories of all peoples.Sexual Partners: Married or single individuals who share sexual relations.Philosophy: A love or pursuit of wisdom. A search for the underlying causes and principles of reality. (Webster, 3d ed)Famous PersonsPoetry as Topic: Literary and oral genre expressing meaning via symbolism and following formal or informal patterns.Infectious Disease Medicine: A branch of internal medicine concerned with the diagnosis and treatment of INFECTIOUS DISEASES.Candidiasis, Invasive: An important nosocomial fungal infection with species of the genus CANDIDA, most frequently CANDIDA ALBICANS. Invasive candidiasis occurs when candidiasis goes beyond a superficial infection and manifests as CANDIDEMIA, deep tissue infection, or disseminated disease with deep organ involvement.Communicable DiseasesCardiovascular Diseases: Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.Physicians: Individuals licensed to practice medicine.Polonium: Polonium. A radioactive element that is a member of the chalcogen family. It has the atomic symbol Po, atomic number 84, and the atomic weight of the isotope with the longest half-life (209Po) is 208.98. It decays by alpha-emission.Hirschsprung Disease: Congenital MEGACOLON resulting from the absence of ganglion cells (aganglionosis) in a distal segment of the LARGE INTESTINE. The aganglionic segment is permanently contracted thus causing dilatation proximal to it. In most cases, the aganglionic segment is within the RECTUM and SIGMOID COLON.Megacolon: Dilatation of the COLON, often to alarming dimensions. There are various types of megacolon including congenital megacolon in HIRSCHSPRUNG DISEASE, idiopathic megacolon in CONSTIPATION, and TOXIC MEGACOLON.Sleep Paralysis: A common condition characterized by transient partial or total paralysis of skeletal muscles and areflexia that occurs upon awakening from sleep or less often while falling asleep. Stimuli such as touch or sound may terminate the episode, which usually has a duration of seconds to minutes. This condition may occur in normal subjects or be associated with NARCOLEPSY; CATAPLEXY; and hypnagogic HALLUCINATIONS. The pathophysiology of this condition is closely related to the normal hypotonia that occur during REM sleep. (From Adv Neurol 1995;67:245-271)Proto-Oncogene Proteins c-ret: Receptor protein-tyrosine kinases involved in the signaling of GLIAL CELL-LINE DERIVED NEUROTROPHIC FACTOR ligands. They contain an extracellular cadherin domain and form a receptor complexes with GDNF RECEPTORS. Mutations in ret protein are responsible for HIRSCHSPRUNG DISEASE and MULTIPLE ENDOCRINE NEOPLASIA TYPE 2.Enteric Nervous System: Two ganglionated neural plexuses in the gut wall which form one of the three major divisions of the autonomic nervous system. The enteric nervous system innervates the gastrointestinal tract, the pancreas, and the gallbladder. It contains sensory neurons, interneurons, and motor neurons. Thus the circuitry can autonomously sense the tension and the chemical environment in the gut and regulate blood vessel tone, motility, secretions, and fluid transport. The system is itself governed by the central nervous system and receives both parasympathetic and sympathetic innervation. (From Kandel, Schwartz, and Jessel, Principles of Neural Science, 3d ed, p766)Enterocolitis: Inflammation of the MUCOSA of both the SMALL INTESTINE and the LARGE INTESTINE. Etiology includes ISCHEMIA, infections, allergic, and immune responses.Rectum: The distal segment of the LARGE INTESTINE, between the SIGMOID COLON and the ANAL CANAL.Digestive System Surgical Procedures: Surgery performed on the digestive system or its parts.Colostomy: The surgical construction of an opening between the colon and the surface of the body.Netherlands: Country located in EUROPE. It is bordered by the NORTH SEA, BELGIUM, and GERMANY. Constituent areas are Aruba, Curacao, Sint Maarten, formerly included in the NETHERLANDS ANTILLES.Laboratory Infection: Accidentally acquired infection in laboratory workers.Skin DiseasesPrognosis: A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.Bacteriology: The study of the structure, growth, function, genetics, and reproduction of bacteria, and BACTERIAL INFECTIONS.Anatomy: A branch of biology dealing with the structure of organisms.GermanySkin: The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.Societies, Pharmaceutical: Societies whose membership is limited to pharmacists.1,4-alpha-Glucan Branching Enzyme: In glycogen or amylopectin synthesis, the enzyme that catalyzes the transfer of a segment of a 1,4-alpha-glucan chain to a primary hydroxy group in a similar glucan chain. EC 2.4.1.18.ArizonaParkinson Disease: A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)GTP-Binding Protein alpha Subunits, Gs: A family of heterotrimeric GTP-binding protein alpha subunits that activate ADENYLYL CYCLASES.Duodenoscopy: Endoscopic examination, therapy or surgery of the luminal surface of the duodenum.Mitochondrial Dynamics: The continuous remodeling of MITOCHONDRIA shape by fission and fusion in response to physiological conditions.User-Computer Interface: The portion of an interactive computer program that issues messages to and receives commands from a user.Armadillo Domain Proteins: A family of proteins that contain several 42-amino acid repeat domains and are homologous to the Drosophila armadillo protein. They bind to other proteins through their armadillo domains and play a variety of roles in the CELL including SIGNAL TRANSDUCTION, regulation of DESMOSOME assembly, and CELL ADHESION.Crohn Disease: A chronic transmural inflammation that may involve any part of the DIGESTIVE TRACT from MOUTH to ANUS, mostly found in the ILEUM, the CECUM, and the COLON. In Crohn disease, the inflammation, extending through the intestinal wall from the MUCOSA to the serosa, is characteristically asymmetric and segmental. Epithelioid GRANULOMAS may be seen in some patients.Antiparkinson Agents: Agents used in the treatment of Parkinson's disease. The most commonly used drugs act on the dopaminergic system in the striatum and basal ganglia or are centrally acting muscarinic antagonists.Levodopa: The naturally occurring form of DIHYDROXYPHENYLALANINE and the immediate precursor of DOPAMINE. Unlike dopamine itself, it can be taken orally and crosses the blood-brain barrier. It is rapidly taken up by dopaminergic neurons and converted to DOPAMINE. It is used for the treatment of PARKINSONIAN DISORDERS and is usually given with agents that inhibit its conversion to dopamine outside of the central nervous system.

The clinicopathological spectrum of Rosenthal fibre encephalopathy and Alexander's disease: a case report and review of the literature. (1/47)

Alexander's disease is a leucodystrophy that usually presents in early childhood, but can infrequently arise in adults. It is characterised pathologically by megalencephaly, demyelination, and the presence of numerous Rosenthal fibres. Most cases have been shown to be due to mutations in the gene encoding glial fibrillary acidic protein. In rare instances, numerous Rosenthal fibres have been found at autopsy in patients who have suffered protracted debilitating systemic illnesses, some with associated brain stem signs, and in very rare instances in patients with no apparent neurological abnormality. The term "Rosenthal fibre encephalopathy" is used to distinguish these cases from those of Alexander's disease. We report the first case of Rosenthal fibre encephalopathy in a young man with AIDS, and review the literature.  (+info)

Alexander-disease mutation of GFAP causes filament disorganization and decreased solubility of GFAP. (2/47)

Alexander disease is a fatal neurological illness characterized by white-matter degeneration and the formation of astrocytic cytoplasmic inclusions called Rosenthal fibers, which contain the intermediate filament glial fibrillary acidic protein (GFAP), the small heat-shock proteins HSP27 and alphaB-crystallin, and ubiquitin. Many Alexander-disease patients are heterozygous for one of a set of point mutations in the GFAP gene, all of which result in amino acid substitutions. The biological effects of the most common alteration, R239C, were tested by expressing the mutated protein in cultured cells by transient transfection. In primary rat astrocytes and Cos-7 cells, the mutant GFAP was incorporated into filament networks along with the endogenous GFAP and vimentin, respectively. In SW13Vim(-) cells, which have no endogenous cytoplasmic intermediate filaments, wild-type human GFAP frequently formed filamentous bundles, whereas the R239C GFAP formed 'diffuse' and irregular patterns. Filamentous bundles of R239C GFAP were sometimes formed in SW13Vim(-) cells when wild-type GFAP was co-transfected. Although the presence of a suitable coassembly partner (vimentin or GFAP) reduced the potential negative effects of the R239C mutation on GFAP network formation, the mutation affected the stability of GFAP in cells in a dominant fashion. Extraction of transfected SW13Vim(-) cells with Triton-X-100-containing buffers showed that the mutant GFAP was more resistant to solubilization at elevated KCl concentrations. Both wild-type and R239C GFAP assembled into 10 nm filaments with similar morphology in vitro. Thus, although the R239C mutation does not appear to affect filament formation per se, the mutation alters the normal solubility and organization of GFAP networks.  (+info)

Gene expression analysis in mice with elevated glial fibrillary acidic protein and Rosenthal fibers reveals a stress response followed by glial activation and neuronal dysfunction. (3/47)

Alexander disease is a fatal neurodegenerative disorder resulting from missense mutations of the intermediate filament protein, GFAP. The pathological hallmark of this disease is the formation of cytoplasmic protein aggregates within astrocytes known as Rosenthal fibers. Transgenic mice engineered to over-express wild-type human GFAP develop an encephalopathy with identical aggregates, suggesting that elevated levels of GFAP in addition to mutant protein contribute to the pathogenesis of this disorder. To study further the effects of elevated GFAP and Rosenthal fibers per se, independent of mutations, we performed gene expression analysis on olfactory bulbs of transgenic mice at two different ages to follow the progression of pathology. The expression profiles reveal a stress response that includes genes involved in glutathione metabolism, peroxide detoxification and iron homeostasis. Many of these genes are regulated by the transcription factor Nfe2l2, which is also increased in expression at 3 weeks. An immune-related response occurs with activation of cytokine and cytokine receptor genes, complement components and acute phase response genes. These transcripts are further elevated with age, with additional induction of macrophage-specific markers such as Mac1 and CD68, suggesting activation of microglia. At 4 months, decreased expression of genes for microtubule-associated proteins, vesicular trafficking proteins and neurotransmitter receptors becomes apparent. Interneuron-specific transcription factors including Dlx family members and Pax6 are downregulated as well as Gad1 and Gad2, suggesting impairment of GABAergic granule cells. Together, these data implicate an initial stress response by astrocytes, which results in the activation of microglia and compromised neuronal function.  (+info)

Plectin regulates the organization of glial fibrillary acidic protein in Alexander disease. (4/47)

Alexander disease (AxD) is a rare but fatal neurological disorder caused by mutations in the astrocyte-specific intermediate filament protein glial fibrillary acidic protein (GFAP). Histologically, AxD is characterized by cytoplasmic inclusion bodies called Rosenthal fibers (RFs), which contain GFAP, small heat shock proteins, and other undefined components. Here, we describe the expression of the cytoskeletal linker protein plectin in the AxD brain. RFs displayed positive immunostaining for plectin and GFAP, both of which were increased in the AxD brain. Co-localization, co-immunoprecipitation, and in vitro overlay analyses demonstrated direct interaction of plectin and GFAP. GFAP with the most common AxD mutation, R239C (RC GFAP), mainly formed abnormal aggregates in human primary astrocytes and murine plectin-deficient fibroblasts. Transient transfection of full-length plectin cDNA converted these aggregates to thin filaments, which exhibited diffuse cytoplasmic distribution. Compared to wild-type GFAP expression, RC GFAP expression lowered plectin levels in astrocytoma-derived stable transfectants and plectin-positive fibroblasts. A much higher proportion of total GFAP was found in the Triton X-insoluble fraction of plectin-deficient fibroblasts than in wild-type fibroblasts. Taken together, our results suggest that insufficient amounts of plectin, due to RC GFAP expression, promote GFAP aggregation and RF formation in AxD.  (+info)

Neuropathology for the neuroradiologist: Rosenthal fibers. (5/47)

Distinctive intracellular structures known as inclusions may be occasionally observed on stained tissue preparations and may further suggest a specific diagnosis. Pathologists rely on these findings much as radiologists rely on findings revealed in the gray-scale patterns of densities and intensities on images. Appreciation of these inclusions can enhance the interactions of the neuroradiologist with the neuropathologist and deepen understanding of certain conditions. This report reviews the neuropathologically observed intracellular inclusions known as Rosenthal fibers in the context of Alexander disease and slow-growing tumors such as pilocytic astrocytoma.  (+info)

The Alexander disease-causing glial fibrillary acidic protein mutant, R416W, accumulates into Rosenthal fibers by a pathway that involves filament aggregation and the association of alpha B-crystallin and HSP27. (6/47)

Here, we describe the early events in the disease pathogenesis of Alexander disease. This is a rare and usually fatal neurodegenerative disorder whose pathological hallmark is the abundance of protein aggregates in astrocytes. These aggregates, termed "Rosenthal fibers," contain the protein chaperones alpha B-crystallin and HSP27 as well as glial fibrillary acidic protein (GFAP), an intermediate filament (IF) protein found almost exclusively in astrocytes. Heterozygous, missense GFAP mutations that usually arise spontaneously during spermatogenesis have recently been found in the majority of patients with Alexander disease. In this study, we show that one of the more frequently observed mutations, R416W, significantly perturbs in vitro filament assembly. The filamentous structures formed resemble assembly intermediates but aggregate more strongly. Consistent with the heterozygosity of the mutation, this effect is dominant over wild-type GFAP in coassembly experiments. Transient transfection studies demonstrate that R416W GFAP induces the formation of GFAP-containing cytoplasmic aggregates in a wide range of different cell types, including astrocytes. The aggregates have several important features in common with Rosenthal fibers, including the association of alpha B-crystallin and HSP27. This association occurs simultaneously with the formation of protein aggregates containing R416W GFAP and is also specific, since HSP70 does not partition with them. Monoclonal antibodies specific for R416W GFAP reveal, for the first time for any IF-based disease, the presence of the mutant protein in the characteristic histopathological feature of the disease, namely Rosenthal fibers. Collectively, these data confirm that the effects of the R416W GFAP are dominant, changing the assembly process in a way that encourages aberrant filament-filament interactions that then lead to protein aggregation and chaperone sequestration as early events in Alexander disease.  (+info)

Synergistic effects of the SAPK/JNK and the proteasome pathway on glial fibrillary acidic protein (GFAP) accumulation in Alexander disease. (7/47)

Protein aggregates in astrocytes that contain glial fibrillary acidic protein (GFAP), small heat shock proteins, and ubiquitinated proteins are termed Rosenthal fibers and characterize Alexander disease, a leukodystrophy caused by heterozygous mutations in GFAP. The mechanisms responsible for the massive accumulation of GFAP in Alexander disease remain unclear. In this study, we show that overexpression of both wild type and R239C mutant human GFAP led to cytoplasmic inclusions. GFAP accumulation also led to a decrease of proteasome activity and an activation of the MLK2-JNK pathway. In turn, the expression of activated mixed lineage kinases (MLKs) induced JNK activation and increased GFAP accumulation, whereas blocking the JNK pathway decreased GFAP accumulation. Activated MLK also inhibited proteasome function. A direct inhibition of proteasome function pharmacologically further activated JNK. Our data suggest a synergistic interplay between the proteasome and the SAPK/JNK pathway in the context of GFAP accumulation. Feedback interactions among GFAP accumulation, SAPK/JNK activation, and proteasomal hypofunction cooperate to produce further protein accumulation and cellular stress responses.  (+info)

A case of infantile Alexander disease accompanied by infantile spasms diagnosed by DNA analysis. (8/47)

Alexander disease (AD) is a rare leukodystrophy of the central nervous system of unknown etiology. AD is characterized by progressive failure of central myelination and the accumulation of Rosenthal fibers in astrocytes, and is inevitably lethal in nature. Symptomatically, AD is associated with leukoencephalopathy with macrocephaly, seizures, and psychomotor retardation in infants, and usually leads to death within the first decade. Its characteristic magnetic resonance imaging (MRI) findings have been described as demyelination predominantly in the frontal lobe. Moreover, dominant mutations in the GFAP gene, coding for glial fibrillary acidic protein (GFAP), a principal astrocytic intermediate filament protein, have been shown to lead to AD. The disease can now be detected by genetic diagnosis. We report the Korean case of an 8-month-old male patient with AD. He was clinically characterized due to the presence of psychomotor retardation, megalencephaly, spasticity, and recurrent seizures including infantile spasms which is a remarkable presentation. Demyelination in the frontal lobe and in a portion of the temporal lobe was demonstrated by brain MRI. Moreover, DNA analysis of peripheral blood showed the presence of a R239L mutation in the GFAP gene, involving the replacement of guanine with thymine.  (+info)

*Alexander disease

"MUTATION KEY TO ALEXANDER DISEASE" - United Press International GeneReviews/NCBI/NIH/UW entry on Alexander disease alexander_ ... Alexander disease may also be revealed by genetic testing for the known cause of Alexander disease. A rough diagnosis may also ... Alexander disease belongs to leukodystrophies, a group of diseases that affect the growth or development of the myelin sheath. ... Alexander disease, also known as fibrinoid leukodystrophy, is a progressive and fatal neurodegenerative disease. It is a rare ...

*Glial fibrillary acidic protein

GeneReviews/NCBI/NIH/UW entry on Alexander disease OMIM entries on Alexander disease Glial Fibrillary Acidic Protein at the US ... "Alexander Disease". Medical College of Wisconsin. Hagemann TL, Connor JX, Messing A (Oct 2006). "Alexander disease-associated ... Chen YS, Lim SC, Chen MH, Quinlan RA, Perng MD (Oct 2011). "Alexander disease causing mutations in the C-terminal domain of ... GFAP therefore plays an important role in the pathogenesis of Alexander disease. Notably, the expression of some GFAP isoforms ...

*List of OMIM disorder codes

CYP11B1 Alexander disease; 203450; GFAP Alexander disease; 203450; NDUFV1 Alkaptonuria; 203500; HGD Allan-Herndon-Dudley ... RNF212 Refsum disease; 266500; PEX7 Refsum disease; 266500; PHYH Refsum disease, infantile form; 266510; PEX26 Refsum disease, ... PSEN1 Alzheimer disease-10; 104300; AD10 Alzheimer disease-2; 104310; APOE Alzheimer disease-4; 606889; PSEN2 Alzheimer disease ... RLBP1 Niemann-Pick disease, type A; 257200; SMPD1 Niemann-Pick disease, type B; 607616; SMPD1 Niemann-Pick disease, type C1; ...

*Proteopathy

Quinlan RA, Brenner M, Goldman JE, Messing A (2007). "GFAP and its role in Alexander Disease". Exp Cell Res. 313 (10): 2077- ... include such diseases as Creutzfeldt-Jakob disease and other prion diseases, Alzheimer's disease, Parkinson's disease, ... disease]; proteopathies pl.; proteopathic adj.) refers to a class of diseases in which certain proteins become structurally ... Hardy J (2005). "Expression of normal sequence pathogenic proteins for neurodegenerative disease contributes to disease risk: ' ...

*List of pathologists

... see Alexander disease). Friedrich August von Ammon (1799-1861), German ophthalmologist and pathologist. Nikolay Anichkov (1885- ... Alexander A. Maximow (1874-1928), Russian-American scientist, histologist and embryologist. John McCrae (1872-1918), Canadian ... William Boog Leishman (1865-1926), English authority on the pathology of human parasitic diseases (see leishmaniasis) George ... Adolf Weil (1848-1916), German physician and pathologist (see Weil's disease). Ronald S. Weinstein (born 1938), American ...

*NDUFV1

... are associated with Alexander disease". Nature Genetics. 27 (1): 117-20. doi:10.1038/83679. PMID 11138011. Bénit P, Chretien D ... liver disease, Leigh syndrome, Leber hereditary optic neuropathy, and some forms of Parkinson disease. GRCh38: Ensembl release ... It causes a wide range of clinical disorders, ranging from lethal neonatal disease to adult-onset neurodegenerative disorders. ...

*Rosenthal fiber

Its presence is associated with either pilocytic astrocytoma (more common) or Alexander's disease (a rare leukodystrophy). They ...

*Macrocephaly

... such as Alexander disease, Canavan disease, and megalencephalic leukoencephalopathy with subcortical cysts; and glutaric ... Dumas L.; Sikela J.M. (2009). "DUF1220 Domains, Cognitive Disease, and Human Brain Evolution". Cold Spring Harb. Symp. Quant. ... PTEN mutations such as Cowden disease, neurofibromatosis type 1, and tuberous sclerosis; overgrowth syndromes such as Sotos ...

*Stephanie Messenger

After months of testing by specialists the doctors concluded he had a genetic condition called Alexander's disease. They warned ... have eradicated many diseases that claimed so many lives in the past. Her children are also benefiting from the sensible ... stories it was the vaccine that killed him and not a genetic disease. She has since stated that there is a conspiracy with ... "It's been driven by parents generally at a community level who were concerned about the emergence of diseases like whooping ...

*The Stennis Foundation

Leukodystrophy Metachromatic leukodystrophy Adrenoleukodystrophy Krabbe disease Alexander disease Canavan disease Pelizaeus- ... Merzbacher disease The Stennis Foundation's home page. ...

*Cytoskeleton

Alexander Disease, and muscular dystrophy. Different intermediate filaments are: made of vimentins. Vimentin intermediate ... Diseases, such as amyotrophic lateral sclerosis, Alzheimer's Disease, Huntington's disease, and Parkinson's disease have had ... Alzheimer's disease is much like Parkinson's in that it is also a neurodegenerative disease that affects the cytoskeleton. Tau ... Parkinson's disease is a condition that causes the degradation of neurons, resulting in tremors, rigidity, and other non-motor ...

*DMOZ - Health: Conditions and Diseases: Neurological Disorders: Demyelinating Diseases: Leukodystrophy

Alexander Disease Information sheet compiled by NINDS, the National Institute of Neurological Disorders and Stroke. ... Dylan has a very rare neurological disorder, Alexanders disease (Leukodystrophy). His story, his progress, and photographs. ... voluntary health organization dedicated to providing patients and their families with information about their disease and ...

*List of eponymously named diseases

Fuller Albright Alexander disease - William Stuart Alexander Alibert-Bazin syndrome - Jean-Louis-Marc Alibert, Pierre-Antoine- ... Related disease naming structures reference place names (Bornholm disease, Lyme disease, Ebola virus disease), and societies, ... Lynch Machado-Joseph disease (a.k.a. Machado-Joseph Azorean disease, Machado disease, Joseph's disease) - named for William ... examples being Lou Gehrig's disease, Hartnup disease, and Mortimer's disease. In at least one instance, Machado-Joseph disease ...

*Death of Alexander the Great

The Diseases of Alexander the Great", Journal of the History of the Neurosciences, Vol. 13, 2004, pg. 154 Robert S. Bianchi. " ... "Alexander the Great and West Nile Virus Encephalitis". CDC. Retrieved Aug 21, 2011. "Disease, not conflict, ended the reign of ... Proposed causes of Alexander's death included alcoholic liver disease, fever, and strychnine poisoning, but little data support ... When Alexander's symptoms were entered to the Global Infectious Disease Epidemiology Network, influenza gained the highest ...

*Dementia

Alexander disease Canavan disease Cerebrotendinous xanthomatosis Dentatorubral-pallidoluysian atrophy Epilepsy Fatal familial ... Tay-Sachs disease, and Wilson's disease (all recessive). Wilson's disease is particularly important since cognition can improve ... For Lyme disease and neurosyphilis, testing should be done if there are risk factors for those diseases in the person. Because ... Alzheimer's disease accounts for up to 50% to 70% of cases of dementia. The most common symptoms of Alzheimer's disease are ...

*Astrogliosis

... a form of multiple sclerosis Rasmussen's syndrome autoantibody destruction of astrocytes causes seizures In Alexander's disease ... Although further research is needed, BB14 has the potential to treat a variety neurological diseases. Further research of ... Various studies have shown the role of astrocytes in diseases such as Alzheimer's, amyotrophic lateral sclerosis (ALS), ... The inflammation caused by reactive astrogliosis augments many of these neurological diseases. Current studies are researching ...

*List of MeSH codes (C16)

... alexander disease MeSH C16.320.400.050 --- amyloid neuropathies, familial MeSH C16.320.400.150 --- canavan disease MeSH C16.320 ... tay-sachs disease MeSH C16.320.565.150.435.825.300.300.920 --- tay-sachs disease, ab variant MeSH C16.320.565.150.435.825. ... glycogen storage disease type i MeSH C16.320.565.202.449.500 --- glycogen storage disease type ii MeSH C16.320.565.202.449.510 ... glycogen storage disease type iv MeSH C16.320.565.202.449.560 --- glycogen storage disease type v MeSH C16.320.565.202.449.580 ...

*Chromosome 17 (human)

The following diseases are related to genes on chromosome 17: 17Q21.31 Microdeletion Syndrome Alexander disease Andersen-Tawil ... Gilbert F (1998). "Disease genes and chromosomes: disease maps of the human genome. Chromosome 17". Genet Test. 2 (4): 357-81. ... von Recklinghausen disease, Watson disease) (17q11.2) SLC6A4: Serotonin transporter linked to Obsessive Compulsive Disorder ( ... Camptomelic dysplasia Canavan disease Cerebroretinal microangiopathy with calcifications and cysts Charcot-Marie-Tooth disease ...

*Rustin McIntosh

Hattie Alexander (infectious disease), William Silverman (neonatology), and John Caffey (radiology). McIntosh published ... son of Luther Emmett Holt) were the editors of select editions of the textbooks Holt's Diseases of Infancy and Childhood (10th ...

*List of diseases (A)

Alcoholic hepatitis Alcoholic liver cirrhosis Aldolase A deficiency Aldred syndrome Aleukemic leukemia cutis Alexander disease ... This is a list of diseases starting with the letter "A". Diseases Alphabetical list 0-9 A B C D E F G H I J K L M N O P Q R S T ... extrinsic allergic Alves Dos Santos Castello syndrome Alzheimer's disease Alzheimer's disease, early-onset Alzheimer's disease ... Alpers disease Alpha 1-antitrypsin deficiency Alpha-2 deficient collagen disease Alpha-ketoglutarate dehydrogenase deficiency ...

*Alexander (grape)

The Alexander combined disease and pest resistance from North American grapes with some of the better qualities of European ... Alexander is also a synonym of another American hybrid grape variety, Isabella. There is also a separate Alexander Winter grape ... The Alexander grape may be extinct, and it is not known exactly if any live material of the variety still exists. Alexander is ... The Alexander grape is a hybrid grape of Vitis labrusca and another species, which may probably be Vitis vinifera. In the 18th ...

*List of MeSH codes (C10)

... alexander disease MeSH C10.314.400.375 --- canavan disease MeSH C10.314.400.500 --- leukodystrophy, globoid cell MeSH C10.314. ... alexander disease MeSH C10.574.500.050 --- amyloid neuropathies, familial MeSH C10.574.500.300 --- canavan disease MeSH C10.574 ... lewy body disease MeSH C10.228.662.600.400 --- parkinson disease MeSH C10.228.662.600.700 --- parkinson disease, secondary MeSH ... lewy body disease MeSH C10.228.140.079.862.500 --- parkinson disease MeSH C10.228.140.079.862.800 --- parkinson disease, ...

*Elijah Alexander

The disease was discovered after Alexander had bloodwork in Costa Rica while on a golfing vacation. He underwent chemotherapy ... Alexander did not start in 1993, but he appeared in 16 games. In 1994, Alexander started all 16 games and he registered a ... "KSU, NFL LB Alexander dies". Topeka Capital-Journal. March 25, 2010. Retrieved August 8, 2014. "Elijah Alexander". Pro-Football ... Elijah Alfred Alexander III (August 2, 1970 - March 24, 2010) was a linebacker who played ten seasons in the NFL for the Tampa ...

*Russian interregnum of 1825

Diebitsch reported the state of Alexander's health to Constantine in Warsaw. The disease consumed Alexander and on November 29 ... Alexander struggled for two more days and died at 10:50 on December 1 [O.S. November 19]. At the moment of Alexander's demise, ... Alexander was aware of the crisis but never tackled its root cause, the oversized peacetime army of 800,000 men. Alexander ... Ivan de Witt and Alexander Boshnyak, the informers who kept Alexander updated on the unfolding Decembrist conspiracy in the ...

*Evoor

Once swaying healthy coconut palms have become pale with root wilt disease and the sandy pathways are replaced by bituminous ... healthy coconut plantations and picturesque thatched houses intertwined by white sandy country roads. Things have drastically ...

*Chilean art

Worked with the father of modern geography, Alexander von Humboldt. Raymond Monvoisin = French portrait painter, contributed to ... causing many to die young from diseases such as malaria and tuberculosis. The 13 Generation emerged from the country's poorest ... Alexander Simón, Giovatto Molinelli and Theodor Ohlsen. The Chilean precursors of Chilean painting were, like their foreign ...
Alexander disease, also known as fibrinoid leukodystrophy, is a progressive and fatal neurodegenerative disease. It is a rare genetic disorder and mostly affects infants and children, causing developmental delay and changes in physical characteristics. Delays in development of some physical, psychological and behavioral skills; progressive enlargement of the head (macrocephaly), seizures, spasticity, and in some cases also hydrocephalus, idiopathic intracranial hypertension, and dementia. Alexander disease is a genetic disorder affecting the midbrain and cerebellum of the central nervous system. It is caused by mutations in the gene for glial fibrillary acidic protein (GFAP) that maps to chromosome 17q21. It is inherited in an autosomal dominant manner, such that the child of a parent with the disease has a 50% chance of inheriting the condition, if the parent is heterozygotic. However, most cases arise de novo as the result of sporadic mutations. Alexander disease belongs to leukodystrophies, a ...
Alexander disease is a rare, progressive, and generally fatal neurological disorder that results from dominant mutations affecting the coding region of GFAP, the gene encoding glial fibrillary acidic protein, the major intermediate filament protein of astrocytes in the CNS. A key step in pathogenesis appears to be the accumulation of GFAP within astrocytes to excessive levels. Studies using mouse models indicate that the severity of the phenotype correlates with the level of expression, and suppression of GFAP expression and/or accumulation is one strategy that is being pursued as a potential treatment. With the goal of identifying biomarkers that indirectly reflect the levels of GFAP in brain parenchyma, we have assayed GFAP levels in two body fluids in humans that are readily accessible as biopsy sites: CSF and blood. We find that GFAP levels are consistently elevated in the CSF of patients with Alexander disease, but only occasionally and modestly elevated in blood. These results provide the
Alexander Disease on National Stem Cell Foundation | Alexander disease is a leukodystrophy, a group of more than 15 rare genetic disorders that cause…
Find best Doctors for Alexander Disease in Garia Kolkata. Get medication advice from our expert doctors & book appointment for Alexander Disease online at Ask Apollo.
Prust et al, characterized 30 patients with Alexander disease and reviewed 185 previously reported cases in an effort to better determine the disease’s phenotypes and correlations with age at onset and genetic mutation. Based on their results, they propose to revise the Alexander’s disease subtypes from three to only two. Type I is characterized by early age at onset, seizures, encephalopathy, paroxysmal deterioration, failure to thrive, developmental delay and hallmark radiological features. In contrast, type II manifests across the lifespan and is characterized by autonomic dysfunction, bulbar symptoms, ocular movement abnormalities and palatal myoclonus and is largely without neurocognitive or developmental deficits.. Periklis Makrythanasis MD, PhD. http://www.neurology.org/content/77/13/1287.abstract?sid=fb3fb700-a768-4d35-a0b3-9d770db7cadf. ...
Palatal tremor is essential (EPT), where isolated, or symptomatic (SPT), where part of a symptom complex. SPT is reported with lesions in the dentato-rubro-olivary pathway and in neurodegenerative and genetic disorders. Some patients have the poorly understood progressive ataxia and palatal tremor (PAPT).. We report a series of twelve patients with SPT. Two have been diagnosed with multi-system atrophy without pathological confirmation. Two have vascular disease affecting the dentato-rubro-olivary pathway. One has mutation-proven Alexander Disease. The remaining seven are all male and classified as sporadic PAPT.. The age range at symptom onset is 36-87 years (36-80 in the PAPT group). All twelve have ataxia. Of the PAPT group, five of seven (71%) have dysarthria. Two PAPT patients had normal DAT scans, and two tested negative for POLG1 and Alexander Disease. Eleven of the twelve (except the Alexander Disease patient) had bilateral olivary hypertrophy on brain MRI.. Palatal tremor is often ...
ORAL HISTORY OF JAMES (JIM) ALEXANDER Interviewed by Keith McDaniel December 9, 2011 MR. MCDANIEL: This is Keith McDaniel, and today is December the 9th, 2011, and I am at the home of James Alexander in Knoxville. And youre known as - MR. ALEXANDER: Jim. MR. MCDANIEL: Jim - MR. ALEXANDER: To all Oak Ridgers - MR. MCDANIEL: All Oak Ridgers know you as - MR. ALEXANDER: I would be known as Jim. MR. MCDANIEL: Jim Alexander, okay. Well, Mr. Alexander, thanks for taking time to talk to us. MR. ALEXANDER: Well, Im glad that you folks came. I always like to talk about Oak Ridge to anyone who likes to listen. MR. MCDANIEL: Well, good. Well, lets get a little bit of your background. Why dont you tell me something about where you were born and raised, and something about your family? MR. ALEXANDER: Okay. I was born in western Kentucky, a little town called Madisonville. And I guess it was about 1947 that my father was transferred to Knoxville, and Ill have to tell you that that was not a pleasant time ...
Alexander disease, a Leukodystrophy, is a progressive and fatal neurological disorder in which the destruction of white matter in the brain is accompanied by the formation of abnormal deposits known as Rosenthal fibers. Rosenthal fibers are aggregations of protein that occur in astrocytes, one of the so-called "glial" cells of the central nervous system. These aggregates are found occasionally in other disorders, but not with the abundance or particular distribution in the brain that occurs in Alexander disease.. The age of onset is quite variable, ranging from prenatal through the sixth decade. The most common classification divides patients into three categories based on age of onset, infantile (0-2 years), juvenile (2-12 years), and adult (,12 years). More recently, a different classification has been proposed, with only two categories of type I and type II, with the distinction hinging more on distribution of lesions and clinical presentation rather than age of onset (all type I cases being ...
Alexander appeared on every cycle of the television program Americas Next Top Model as the runway coach to the contestants. He was made a judge starting with Cycle 5. As of Cycle 14 of the show, Alexander was replaced as a permanent judge on the panel by Vogue editor at large André Leon Talley.[9] Alexander stayed on as the shows runway coach and has appeared in many of the international versions of the show.[10]. Alexanders nickname "Miss J", or lovingly "Siss J" after the word sister came from Cycle 1 contestant Robin Manning, who often confused Alexander and Jay Manuel and on several occasions referred to Alexander as "Miss J" by accident because of his flamboyant clothing (Alexander often dresses in drag and usually wears a skirt and high heels during runway walking training) and personality. Accordingly, Jay Manuel is referred to as "Mr. Jay", and ANTM contestants often call them "The Jays", "The Two Jays" or "Mr. and Ms. Jay" when they appear together.[11] In 2008, the Jays were cast ...
Alexander disease is a rare, progressive, and generally fatal neurological disorder that results from dominant mutations affecting the coding region of GFAP, the gene encoding glial fibrillary acidic protein, the major intermediate filament protein of astrocytes in the central nervous system. A key step in pathogenesis appears to be the accumulation of GFAP protein within astrocytes to excessive levels. Studies using mouse models indicate that the severity of the phenotype correlates with the level of expression, and suppression of GFAP expression and/or accumulation is one strategy that is being pursued as a potential treatment. With the goal of identifying biomarkers that indirectly reflect the levels of GFAP in brain parenchyma, we have assayed GFAP levels in two body fluids in humans that are readily accessible as biopsy sites - cerebrospinal fluid and blood. We find that GFAP levels are consistently elevated in the CSF of Alexander disease patients, but only occasionally and modestly in ...
The #1 New York Times bestselling account of a neurosurgeons own near-death experience-for readers of 7 Lessons from Heaven. Thousands of people have had near-death experiences, but scientists have argued that they are impossible. Dr. Eben Alexander was one of those scientists. A highly trained neurosurgeon, Alexander knew that NDEs feel real, but are simply fantasies produced by brains under extreme stress.Then, Dr. Alexanders own brain was attacked by a rare illness. The part of the brain that controls thought and emotion-and in essence makes us human-shut down completely. For seven days he lay in a coma. Then, as his doctors considered stopping treatment, Alexanders eyes popped open. He had come back. Alexanders recovery is a medical miracle. But the real miracle of his story lies elsewhere. While his body lay in coma, Alexander journeyed beyond this world and encountered an angelic being who guided him into the deepest realms of super-physical existence. There he met, and spoke with, the Divine
Plotkowski, A., Alexander, J. M. (in press). A sequential sentence test paradigm using revised PRESTO sentence lists. Journal of the American Academy of Audiology.. Alexander, J. M. (2016). Nonlinear frequency compression: Influence of start frequency and input bandwidth on consonant and vowel recognition. Journal of the Acoustical Society of America, 139, 938-957.. Brennan, M. A., McCreery, R., Kopun, J., Alexander, J. M., Lewis, D., Stelmachowicz, P. G. (2016). Masking release in children with hearing loss when using amplification. Journal of Speech Language and Hearing Research, 59, 110-121.. Rallapalli, V., Alexander, J. M. (2015). Neural-Scaled Entropy predicts the effects of nonlinear frequency compression on speech perception. Journal of the Acoustical Society of America, 138, 3061-3072.. Alexander, J. M., Masterson, K. M. (2015). Effects of WDRC release time and number of channels on output SNR and speech recognition. Ear and Hearing, 36, e35-e49.. Alexander, J. M., Kopun, J.G., ...
Introduction. Alexander Fleming Antibiotics One sometimes finds what one is not looking for. Sir Alexander Fleming 1. Alexander Fleming biography 2. The discovery of Penicillin 3. Purification to a stable form and industrial scale production 4. How an antibiotic work 5. Antibiotic resistance 1. Alexander Fleming 1881 - 1955 Alexander Fleming was born in a lonely, rural part of Scotland as the seventh of eight siblings and half-siblings, his family worked an 800-acre farm far away from the nearest house. The Fleming children spent much of their time in the streams, valleys, and moors of the countryside. We unconsciously learned a great deal from nature, said Fleming. When their father died, his eldest son took over the running of the farm. Another brother Tom had studied medicine and was opening a practice in London. Soon, inspired by their brother, four Fleming brothers and a sister were living together in London. Alec, as Alexander was called, had moved to London when he was around 14, and ...
I have just finished reading a book about the life and times of Alexander The Great ("Alexander The Great" by Robin Lane Fox. Published by Penguin Book. ISBN 0-141-02076-8).. I have recently read a number of different books about Alexander but this one, in particular, kept me going throughout. It was interesting and factual without being condescending. This book doesnt try to paint Alexander as either Great or the Devil but as truly a man who set out to exert some degree of revenge but ended up having travelled from the Mediterranean to the Indian Ocean and was, arguably, the first true explorer.. This man not only trod the path of being an explorer but was a conqueror who took with him thousands of followers who also fought battles, disease, distance, hunger, thirst and the geography to travel the miles with him.. Alexander may or may not have been The Great but he was truly remarkable. I am glad to have found and read this book.. ...
Bergfield, K.L., Hanson, K.D., Chen, K., Teipel, S.J., Hampel, H., Rapoport, S.I., Moeller, J.R., & Alexander, G.E. (2010). Age-related networks of regional covariance in MRI gray matter: Reproducible multivariate patterns in healthy aging. Neuroimage, 49, 1750-9. PMID: 19796692. Alexander, G.E., Bergfield, K.L., Chen, K., Reiman, E.M., Hanson, K.D., Lin, L., Bandy, D., Caselli, R.J., & Moeller, J.R. (2012). Gray matter network associated with risk for Alzheimers disease in young to middle-aged adults. Neurobiology of Aging, 33, 2723-32. PMID: 22405043. Alexander, G.E., Ryan, L., Bowers, D., Foster, T.C., Bizon, J.L., Geldmacher, D.S., & Glisky, E.L. (2012). Characterizing cognitive aging in humans with links to animal models. Frontiers in Aging Neuroscience, 4, 21. PMID: 22988439. Raichlen, D.A., & Alexander G.E. (2014). Exercise, APOE genotype, and the evolution of the human lifespan. Trends in Neurosciences, 37, 247-55. (Article featured on journal cover, May, 2014.) PMID: 24690272. Nguyen, ...
https://twitter.com/#!/CCSVI_Society Dr. Alexander (endothelial biologist) now presenting MS and cerebral endothelial dysfunctionDr. Alexander: endothelium becomes sticky with shear: activates leukocytes into brain parenchyma Dr. Alexander: endothelial cells very sensitive to glycemic (glucose) and oxidative stressDr. Alexander: Interferon beta may have ...
Grace Hazel SHOWERS ALEXANDER - Yavapai County Arizona - Grace H. (Showers) Alexander - Young b. Aug. 13, 1874, Whitneys Point, N. Y. d. Nov. 8, 1934, Prescott, Az. COD: Cerebral Hemorrhage w/o John H. Alexander (m) May 27, 1903, Little Ash Creek, Az. Territory w/o James B. Young d/o Daniel & Phebe (Holt) Showers Note: resided in Az. 50 years
Franz Alexander, nascido Ferenc Gábor Alexander, (Budapeste, 22 de janeiro de 1891 - Palm Springs, 8 de março de 1964) foi um médico e psicanalista húngaro judeu radicado nos Estados Unidos. Ele é considerado o fundador da medicina psicossomática de base analítica e da criminologia psicanalítica. 1931, The Criminal, the judge and the public: A psychological analysis. (Together with Hugo Staub. Orig. ed. transl. by Gregory Zilboorg). 1960, The Western mind in transition : an eyewitness story. New York: Random House. 1961, The Scope of psychoanalysis 1921 - 1961: selected papers. 2. pr. New York: Basic Books. 1966, Psychoanalytic Pioneers de Franz Alexander (autor), Samuel Eisenstein (autor), Martin Grotjahn (editor), New York; London: Basic Books. También Transaction Publishers,U.S. (April 1995), ISBN 1-56000-815-6 (10), ISBN 978-1-56000-815-6 (13) Extracto online (en inglés) The corrective emotional experience (1946) (capítulos 2, 4 y 17 del libro de Franz Alexander 1968, The history ...
Genetic genealogy is the new frontier. Our two DNA views are designed to help you use genetic testing to confirm and expand Alexanders genealogy. The DNA Ancestors page shows the specific ancestors from whom Alexander gets his Y chromosome and mitochondrial DNA. Especially helpful for some serious genetic genealogists is the inheritance pattern for Alexanders X chromosome, also shown here. The DNA Descendants page shows exactly who has inherited Alexanders testable DNA. DNA Ancestor Confirmation Aid ...
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Bacterial diversity analysis of moderately thermophilic microflora enriched by different energy sources In this study, cultures grown from explants of rabbit rib perichondrium were exposed to exogenously added transforming growth factor-beta 1 at concentrations of 0.1-10 ng/ml of media. Correlations with the Short Form-36 were used to investigate the convergent validity. Antioxidant status in ceftin dogs with idiopathic dilated cardiomyopathy. The pathological hallmark of Alexander disease is the inclusion body, known as Rosenthal fiber, within the cell bodies and processes of astrocytes. Although IL-4, IL-5, IL-10, and IL-13 each regulate distinct aspects of the granulomatous inflammatory response, IL-13 was identified as the primary mediator of liver fibrosis. Acute effect of whole body vibration on postural control in congenitally blind subjects: clarithromycin a preliminary evidence. Heterokaryons have been utilized for complementation and dominance testing of mutations that affect ...
P,A main neurogenic niche in the adult human brain is the subventricular zone (SVZ). Recent data suggest that the progenitors that are born in the human SVZ migrate via the rostral migratory stream (RMS) towards the olfactory bulb (OB), similar to what has been observed in other mammals. A subpopulation of astrocytes in the SVZ specifically expresses an assembly-compromised isoform of the intermediate filament protein glial fibrillary acidic protein (GFAP-delta). To further define the phenotype of these GFAP-delta expressing cells and to determine whether these cells are present throughout the human subventricular neurogenic system, we analysed SVZ, RMS and OB sections of 14 aged brain donors (ages 74-93). GFAP-delta was expressed in the SVZ along the ventricle, in the RMS and in the OB. The GFAP-delta cells in the SVZ co-expressed the neural stem cell (NSC) marker nestin and the cell proliferation markers proliferating cell nuclear antigen (PCNA) and Mcm2. Furthermore, BrdU retention was found ...
Glial fibrillary acidic protein (GFAP), a 50 kDa protein, is a major intermediate filament protein in mature astrocytes. It is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in the GFAP gene in humans cause Alexander disease, a very rare, fatal neurodegenerative disease that mostly affects infants and children and results in developmental delay and changes in physical characteristics. GFAP is also known as FLJ45472.. ...
Glial fibrillary acidic protein (GFAP), a 50 kDa protein, is a major intermediate filament protein in mature astrocytes. It is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in the GFAP gene in humans cause Alexander disease, a very rare, fatal neurodegenerative disease that mostly affects infants and children and results in developmental delay and changes in physical characteristics. GFAP is also known as FLJ45472.. ...
Thirdly the Alexander Technique may improve the cerebellum, an area of the brain that has been linked with dyslexia and ADD, especially by Dore Centres / DDAT. The main role of the cerebellum is coordination of thoughts and actions, something which is often poor in children with learning difficulties. Through the Alexander Technique you learn to move your body in a controlled manner which requires you to learn a level of mental discipline. It should not be forgotten that the body is a very complex organism that is sending many different pieces of information to the brain: How hot am I? Where are my legs? What can my fingers feel? Do I need to go to the toilet? With all this information rushing into the brain, swamping the under-developed cerebellum, its conceivable that as a coping strategy the brain just ignores it. This could give rise to the clumsiness and inattentive behavior as the child is ignoring the signals the body sends it. With the Alexander Technique, it possible to become aware of ...
Michael J. Alexander, MD, has led and participated in numerous research projects funded by the National Institutes of Health (NIH) and industry. Over the past five years, his clinical research has focused on four primary areas: brain aneurysms (for example, Alexander was the institutional principal investigator for the Liberty trial and the FRED flow diverter trial), atherosclerotic disease (cholesterol plaque) of the carotid arteries and cerebral arteries (Alexander was a leader on the initial steering committee of the NIH-funded SAMMPRIS trial, was the institutional principal investigator on the SAPPHIRE WW carotid stent trial, and was the national principal investigator for the WEAVE intracranial stent trial), acute embolic stroke (he was co-investigator of the NIH-funded MR Rescue stroke trial and institutional principal investigator for the POSITIVE, THERAPY, START and PICS stroke trials), and cerebral (brain) hemorrhage (he was co-investigator in the NIH-funded MISTIE 3 and CLEAR 3 ...
THE #1 NEW YORK TIMES BESTSELLING ACCOUNT OF A NEUROSURGEONS OWN NEAR-DEATH EXPERIENCE.Internationally acclaimed neurosurgeon Dr Eben Alexander always considered himself a man of science. His unwavering belief in evidence-based medicine fuelled a career in the top medical institutions of the world. But all this was set to change. One morning in 2008 he fell into a coma after suffering a rare form of bacterial meningitis. Scans of his brain revealed massive damage. Death was deemed the most likely outcome. As his family prepared themselves for the worst, something miraculous happened. Dr Alexanders brain went from near total inactivity to awakening. He made a full recovery but he was never the same. He woke certain of the infinite reach of the soul, he was certain of a life beyond death. In this astonishing book, Dr Alexander shares his experience, pieced together from the notes he made as soon as he was able to write again. Unlike other accounts of near-death experiences, he is able to explain in
Join Dave Alexander for the World of Western Swing Saturday mornings at 8 am.. Once you have seen Dave Alexander in concert it is easy to understand why he has been named Entertainer Of The Year by the Academy of Western Artists.. Throughout his successful and award winning career this dynamic entertainer has gained the respect of his peers while mesmerizing his audiences with each performance. His talents as a performer are unsurpassed as recently exemplified upon his induction in to the Texas Western Swing Hall of Fame, Male Vocalist of The Year by the Academy of Western Artists and newly appointed Cadillac sponsorship.. Dave has performed and recorded with the biggest names in country music such as George Strait, Toby Keith and LeAnn Rimes while carving out his own stellar career in the music industry. The three time GRAMMY nominee remains as one of the nations top selling western artists.. Alexander has been recognized as having created the finest Western Big Band ever assembled to deliver ...
RJ Fleck holds advanced degrees from the Universities of Toronto, California, and Stanford University in music performance, composition, computer science and digital audio engineering. He is an accomplished pianist, teaches music and managed a small digital audio research lab and residency (Mackenzie Post Digital) from his home in the Little Portugal neighbourhood of downtown Toronto for many years.. For the last several years, he has been increasingly devoting time to somatic and embodiment practices such as the Alexander Technique, Pilates, Tai Chi, Yoga and Vipassana Meditation. He completed certification at the Susan Sinclair Alexander Technique and Pilates Centre as a teacher of the Alexander Technique in 2007 and as an instructor of the Pilates Method in 2009. He certified as an instructor of Yoga with Octopus Garden in 2012.. ...
Johns Thoughts: Not sure why Goldust is a 205 Live mainstay now. He even wrestled on this show. Are they building towards a Goldust and Cedric Alexander program because I dont think that would be the worst thing in the world with Goldust going back to that promising throwback heel character and Cedric needing some sort of character development. I would roll my eyes a bit at Cedric essentially taking the place of Ron Killings in this feud.. Enzo Amore made his entrance selling his injuries. He did his usual speech and the crowd wasnt as participatory to start but eventually the cheers built up. Enzo built up Tony Nese and called him "Tony Abs". Nese then did his unnecessarily long ass entrance while cutting his hard to hear his usual promo without a microphone. Cedric Alexander made his entrance to his remixed theme music. Its the same lyrics but theyve done some work editing the background music to the vocals…. 2. Tony Nese (w/Enzo Amore) vs. Cedric Alexander. Ugh. Tony Nese took steps ...
See ratings and reviews, wine tasting notes, food pairings, and find where to buy Vintage 2009 Rodney Strong Cabernet Sauvignon Alexander Valley Single Vineyard Alexanders Crown Vineyard
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Alexander Ivanovitch Spiridovitch was born August 5, 1873 (old style) in the small town of Kemi in the Archangel government, on the shore of the White Sea. His father, Ivan Matveyovitch Spiridovitch was a Second Captain in command of a regiment of border guards.. The Spiridovitch family was listed in the Book of the Nobilitys Sixteenth section, having been granted a hereditary Noble Title by Tsar Alexis in 1668, and confirmed by an Ukaze which granted them land and serfs in the Smolensk region.. Second Capt. Spiridovitch immediately made a declaration of his sons birth to the Assembly of the Nobility of Smolensk for which he was given a certificate of Nobility in his sons name.. His father instilled in him as his guiding principles a love of God, Tsar and devotion to his country: For the Faith, For the Tsar and for the Nation was his motto.. However much his father loved young Alexander Ivanovitch, he was raised strictly in accordance with the customs of the era and later recalled that his ...
WHAT fellow art thou, who darest thus to lie at thy ease in our presence, when all others, as thou seest, rise to do us homage? dost thou not know us?. Diog. I cannot say I do: but by the number of thy attendants, by the splendour of thy habit; but, above all, by the vanity of thy appearance, and the arrogance of thy speech, I conceive thou mayst be Alexander the son of Philip.. Alex. And who can more justly challenge thy respect, than Alexander, at the head of that victorious army, who hath performed such wonderful exploits, [1] and, under his conduct, hath subdued the world?. Diog. Who? why the tailor who made me this old cloke.. Alex. Thou art an odd fellow, and I have a curiosity to know thy name.. Diog. I am not ashamed of it: I am called Diogenes: a name composed of as many and as well-sounding syllables as Alexander.. Alex. Diogenes, I rejoice at this encounter. I have heard of thy name, and been long desirous of seeing thee; in which wish, since fortune hath accidentally favoured me, I ...
Ashley threw herself into running Alexanders therapy program full-time, and my daily routine as a work-from-home freelancer soon involved at least as much duty as a therapy assistant. The stress was enormous, and our debt grew whenever we sacrificed more work time for Alexanders sessions. For my wife, the manager of our ersatz team, administering the multiple programs meant constructing a self-made cage. Once, our professional lives had involved extended research trips, and now whole weeks could pass without either of us leaving the house except to ferry our daughter to and from school.. Still, we agreed that the strain on our family was far better than the despair of not knowing what to do. We believed, most of the time, that there was a smart little boy straining to emerge from those flapping, disorganized limbs. Alexanders program required a platoon of volunteer helpers, which meant most of our block knew all about his condition. The spring after he turned three, when he started to walk up ...
Vitamins are essential for the normal growth and development of humans, and include vitamin A, vitamin B, vitamin C, vitamin C, vitamin D, vitamin E, vitamin K and many more. See below for local businesses in Alexander City that give access to vitamins as well as advice and content on fat-soluble vitamins and water-soluble vitamins.
Get information, facts, and pictures about Alexander Graham Bell at Encyclopedia.com. Make research projects and school reports about Alexander Graham Bell easy with credible articles from our FREE, online encyclopedia and dictionary.
Groklaws clone of Sarah Palin a.k.a. Pamela Jones has discovered her panties are all tied up in a wet, sloppy knot again over Alexander Terekhov: Ive been reading some of the amicus briefs filed in the In Re Bilski case pending before the US Supreme Court. There is an amicus brief [PDF] filed with the Supreme Court in the Bilski case that I think will interest you. It discusses software and whether it is math, it misrepresents FOSS, and it pushes software patents. It was filed by Professor Lee Hollaar and IEEE-USA. If that name sounds familiar, it should. Yes, this is the same Professor Hollaar that Alexander Terekhov and Daniel Wallace so often have quoted and linked to in their anti-GPL campaign here and elsewhere on the Internet... Professor Hollaars Amicus Brief in Bilski Tuesday, September 22 2009 @ 04:58 AM EDT http://www.groklaw.net/article.php?story=20090922030639824 Alexander! Whats your secret? How do you incite such passion in the fairer sex? Pheromones? Blond hair and blue ...
During an asthma attack, the airways narrow, causing breathing problems, wheezing and coughing. Asthma can be caused by allergies, pollens, stress or air pollution and can be fatal. The Alexander Technique is a form of therapy involving a series of movements designed to correct posture and bring the body into natural alignment and aid relaxation. The Alexander technique has been used by people with asthma, to try and improve breathing. The review of trials found there was not enough evidence to show the effects of the Alexander Technique in reducing the need to use medication for asthma. More research is needed.. ...
Congratulations to Alexander Szojka for receiving The Natural Sciences and Engineering Research Council of Canada (NSERC)s Alexander Graham Bell Canada Graduate Scholarship - Doctoral Program (CGS-D). The objective of the CGS-D program is to ensure a reliable supply of highly qualified personnel to meet the needs of Canadas knowledge economy. NSERC awards the CGS D to the top-ranked Postgraduate Scholarships-Doctoral (PGS D) applicants. This award will support his PhD research project in knee meniscus tissue engineering with his supervisor Dr. Adetola Adesida. Click button for a list of Alexander Szojkas most recent awards.. ...
Small heat shock proteins (sHsps) are a group of proteins with molecular mass between 12 and 43 kDa. Currently, 11 members of this family have been classified, namely HspB1 to HspB11. HspB1, HspB2, HspB5, HspB6, HspB7, and HspB8, which are expressed in brain have been observed to be related to the pathology of neurodegenerative diseases, including Parkinsons, Alzheimers, Alexanders disease, multiple sclerosis, and human immunodeficiency virus-associated dementia. Specifically, sHsps interact with misfolding and damaging protein aggregates, like Glial fibrillary acidic protein in AxD, β-amyloid peptides aggregates in Alzheimers disease, Superoxide dismutase 1 in Amyotrophic lateral sclerosis and cytosine-adenine-guanine/polyglutamine (CAG/PolyQ) in Huntingtons disease, Spinocerebellar ataxia type 3, Spinal-bulbar muscular atrophy, to reduce the toxicity or increase the clearance of these protein aggregates ...
Small heat shock proteins (sHsps) are a group of proteins with molecular mass between 12 and 43 kDa. Currently, 11 members of this family have been classified, namely HspB1 to HspB11. HspB1, HspB2, HspB5, HspB6, HspB7, and HspB8, which are expressed in brain have been observed to be related to the pathology of neurodegenerative diseases, including Parkinsons, Alzheimers, Alexanders disease, multiple sclerosis, and human immunodeficiency virus-associated dementia. Specifically, sHsps interact with misfolding and damaging protein aggregates, like Glial fibrillary acidic protein in AxD, β-amyloid peptides aggregates in Alzheimers disease, Superoxide dismutase 1 in Amyotrophic lateral sclerosis and cytosine-adenine-guanine/polyglutamine (CAG/PolyQ) in Huntingtons disease, Spinocerebellar ataxia type 3, Spinal-bulbar muscular atrophy, to reduce the toxicity or increase the clearance of these protein aggregates ...
The new study, published online in the current (July 2010) issue of the journal Human Molecular Genetics by a team led by University of Wisconsin-Madison neuroscientist Albee Messing, identifies a set of FDA-approved drugs that seem to tamp down the overproduction of a brain protein that is the hallmark of Alexander disease, a fatal neurodegenerative disorder that affects mostly infants and children.. The new study, carried out during the past five years, provides a glimmer of hope for alleviating a congenital brain disease with existing drugs. Because the disease is so rare, known to have occurred in fewer than 300 people worldwide, the prospects of developing dedicated drugs to treat the condition are almost nonexistent, making such pharmaceutical prospecting the quickest path to effective treatments.. "What we are hoping for is something we can use to manage the disease and improve survival," says Messing, a Waisman Center researcher and a professor of comparative biosciences in the ...
Secondary microcephaly, or also called progressive or evolving microcephaly, may be due to changes in cerebrospinal fluid volume , such as the presence of lesions or occupant substances.. - Increase in the level and volume of cerebrospinal fluid (CSF) : abnormalities in the production, drainage or reabsorption of cerebrospinal fluid can cause an accumulation of this and therefore lead to a hydrocephalus.. - Presence of occupant injuries : this type of alterations refer to the presence of intracerebral structural and vascular malformations , masses or collections. Some of the pathologies that give rise to this type of injuries are: cysts, tumors, bruises, arteriovenous malformations, etc.. - Presence of anomalous substances : this type of alterations refer to the presence of metabolic or deposit diseases such as Alexanders disease, Canavans disease, metabolopathies, etc.. Bone abnormalities. As for the cases of macrocephaly that are due to bone abnormalities, we can find:. - Macrocephaly due to ...
Albinism, ocular 345 Albinotic sensorineural deafness 438 Alexander disease 335 Allodynia 190 Alpha fucosidosis 427 Alpha glucosidosis 427 Alpha iduronidase 427 Alpha mannosidase 427 Alpha melanotropism 484 Alsatian-idiopathic epilepsy 458 Alternative anticonvulsant drugs 466 American Bulldog-Ceroid lipofuscinosis 385, 428 American Miniature Horse-Narcolepsy 470 American StaffordshireTerrier-Cerebellar cortical abiotrophy 367 Amikacin 329 Aminocaproic acid 262 Aminoglycoside antibiotics 329, 439 Amprolium toxicity 421 Ampulla 320 Amygdala 195, 448, 484 Amyotrophic lateral sclerosis (ALS) 102 Analgesia 234, 236 Anatomic diagnosis 487 Anencephaly 39 Angus-Cerebellar cortical abiotrophy 375 Mannosidosis 427 Anhydrosis 175 Anisocoria 169, 360 Anorexia 484 Anosmia 445 Anticonvulsant drugs 466 Antidiuretic hormone 483 Aortic thromboembolism 155 Aperture-lateral 24, 30, 56 Aplasia-Cerebral (telencephalon) 39 Spinal cord-Segmental 50 Apoptosis 27 Appetite control 484 Aqueduct-Mesencephalic 23, 32 ...
Macrocephaly: A congenital abnormality in which the occipitofrontal circumference is greater than two standard deviations above the mean for a given age. It is associated with HYDROCEPHALUS; SUBDURAL EFFUSION; ARACHNOID CYSTS; or is part of a genetic condition (e.g., ALEXANDER DISEASE; SOTOS SYNDROME).
Shirley Wade-Linton, an Alexander Technique teacher and Registered Dietitian in Courtenay, Vancouver Island, British Columbia talks with Robert Rickover about ways in which the Technique can help p...
Senate Hearings to Investigate Ways to Improve EHRs Key Takeaway: Senate Health, Education, Labor and Pensions Committee Chair Lamar Alexander (R-T.N.) said making electronic health records (EHRs) work for clinicians and scientists is among his top priorities during a visit to Vanderbilt University last week. He and HELP Ranking Member Sen. Patty Murray (D-Wash.) have established a bipartisan workgroup to identify ways to improve EHRs.. Why it Matters: The HELP Committee has long been engaged with the health IT stakeholder community and is currently working on policies meant to enable efforts like the Presidents Precision Medicine Initiative. This latest announcement of a bipartisan workgroup likely portends hearings and legislation meant to address lingering challenges with interoperability.. According to HELP Chairman Alexander and Ranking Member Murray, the Senate will go "more in depth" than the House Energy and Commerce (E&C) Committee to fix problems with EHR systems built with $30 ...
... A. Alexander the Great. 1. PRIENE HONORS ANTIGONUS. Tod, GHI 186 (Syll.3 278) Summer, 334. Following his victory over the Persians in the cavalry battle at the Granikos River in May of 334, Alexander proceeded south in Asia Minor and, after his arrival at Ephesos, set about the liberation of the Greek cities (Arrian 1.18.1-2; on Alexanders actions and policy here see esp. E. Badian, Alexander the Great and the Greeks of Asia, Ancient Society and Institutions, Studies Presented to Victor Ehrenberg [Oxford 1966] 37-70). To this period (about August, 334) belongs the present decree of the city of Priene (cf. the reference to autonomy in the prescript). Antigonus, later known as the One-Eyed (Monophthalmos), served in Alexanders army as commander of the allied contingents until early in 333 when he was appointed satrap of Phrygia (Arrian 1.29.3). From Alexanders death in June, 323 until his own on the field at Ipsos in 301, Antigonus r le in the struggles of the successors ...
This book presents a translation, with commentary, of a major Roman source on the end of the reign of Alexander the Great. Book 10 of Curtius Histories covers the reign of terror and mutiny that followed upon Alexanders return from India; and offers the fullest account of the power struggle that began in Babylon immediately after his death.
Get this from a library! Alexander Mcqueen evolution. [Katherine Gleason] -- From Jack the Ripper Stalks His Victims, his 1992 graduate collection, to Platos Atlantis, the last show before his death in 2010, Lee Alexander McQueen was as celebrated for the exquisite ...
B. Multiple Assaults and Separate Convictions. Alexander was separately convicted of four counts of assault with a dangerous weapon for assaulting each of the four survivors of the Marine group. The trial judge made the sentences on three of the four counts consecutive to one another.6 Alexander claims that the evidence does not justify a finding that he assaulted each of the four survivors individually,7 and that, accordingly, he could have been convicted of but one offense of assault. The separate convictions and the consecutive sentences raise a substantial issue for this court.. The Supreme Court has faced in several different contexts the question whether a single criminal act or episode constituted one or more violations of a given statute.8 It is undisputed that the critical factor is the intent of Congress. In addition, where the language of the statute or the statutory scheme in general does not fix the punishment "clearly and without ambiguity," a "rule of lenity" requires that courts ...
Borja Acosta K G (2017). Mariposas (Lepidoptera: Papilionoidea) de la Colección Entomológica del Instituto Alexander von Humboldt. Version 16.1. Instituto de Investigación de Recursos Biológicos Alexander von Humboldt. Occurrence Dataset https://doi.org/10.15472/timk5o accessed via GBIF.org on 2017-10-16 ...
Alexander Arato is General Counsel at Neulion Inc. See Alexander G Aratos compensation, career history, education, & memberships.
The movement work at the Institute was based on the Alexander Technique. The Alexander Technique is introduced as a systematic way of approaching and changing something as complex and habitually familiar as ones physicality.. I begin each class with a physical and vocal warm-up. ...
Alexander Cameron Suites: Rooms were clean and hygienic - See 263 traveler reviews, 68 candid photos, and great deals for Alexander Cameron Suites at TripAdvisor.
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Alexander Ludwig Height Weight Body Statistics. Alexander Ludwig Height -1.88 m, Weight -88 kg, Measurements -47 chest, 16 biceps, 35 waist, girlfriend
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Video source: YouTube/Alexander Polli Alexander Polli, a skydiver and pioneer in BASE jumping known as a YouTube sensation, has died after a wingsuit cra
Dr. Alexander, board certified in pediatrics and neonatal-perinatal medicine, received his medical degree from the Javeriana University in Bogota, Colombia. He completed his pediatric residency at Miami Childrens Hospital in Florida and his neonatal-perinatal medicine fellowship training at Jackson Memorial Hospital in Miami, Florida. After he completed his training, he came to Orlando and became Director of the NICU expanding this unit from six babies to a capacity of 142 beds. Dr. Alexander is the recipient of innumerable awards and has been a key leader in establishing important programs in the Neonatal Intensive Care Unit. He was a leader in building Arnold Palmer Hospital and Winnie Palmer Hospital for Women & Babies. In June, 2010 the NICU was named after Dr. Alexander "Alexander Center for Neonatology".. Dr. Alexanders commitment to these hospitals and the babies in his care are well known. Dr. Alexander serves as the immediate past chair of the Orlando Health Foundations Board of ...
View Alexander Semeonovs MOOC Record on Class Central. Class Central profile pages makes it easy for you to learn about Alexander Semeonovs interests in MOOCs.
The original Alexander cocktail consisted of equal parts gin, crème de cacao liqueur and cream. Over time, other spirits were substituted for the gin - brandy being most popular. The formula has also gradually become more boozy with modern recipes usually calling for one-and-a-half times as much base spirit. Other liqueurs in place of crème de cacao have also been used in modern Alexander riffs.
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At file:///home/bar/mysql-bzr/mysql-trunk-wl946/ based on revid:[email protected] 3365 Alexander Barkov 2011-05-18 WL#946: fixing some test failures. As the datatype of @@timestamp has changed from Sys_var_session_special (ulonglong based) to Sys_var_session_special_double (double bases), its not any more correct to use "~(time_t)0" as the upper limit parameter to constructor. modified: sql/sys_vars.cc === modified file sql/sys_vars.cc --- a/sql/sys_vars.cc 2011-05-18 17:21:03 +0000 +++ b/sql/sys_vars.cc 2011-05-18 19:59:19 +0000 @@ -2730,7 +2730,7 @@ static bool check_timestamp(sys_var *sel static Sys_var_session_special_double Sys_timestamp( "timestamp", "Set the time for this client", sys_var::ONLY_SESSION, NO_CMD_LINE, - VALID_RANGE(0, ~(time_t)0), BLOCK_SIZE(1), + VALID_RANGE(0, TIMESTAMP_MAX_VALUE + 1), BLOCK_SIZE(1), NO_MUTEX_GUARD, IN_BINLOG, ON_CHECK(check_timestamp), ON_UPDATE(update_timestamp), ON_READ(read_timestamp)); Attachment: [text/bzr-bundle] ...
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Dr. Alexander Donath, Sektionsleiter, Koordinator HPC-Cluster, -Bioinformatische Genomik, -Hochleistungsrechner, Tel.: +49 228 9122-344, Fax: +49 228 9122-295
I think it would be difficult to disentangle for a few reasons.. 1. India had been subject to the Aryan migration only around 1,200 years prior. The Aryans were presumably pretty West Eurasian as well, and arguably may have actually been lighter to begin with than Greeks. 2. Alexanders troops also only marched through portions of the subcontinent where the Aryan migration had the heaviest genetic impact. 3. We dont actually know how ancient Greek genetics differed from the those of modern Greeks. We know that many modern Greeks today came from families who spoke South Slavic, Aromanian, Turkish, or Albanian as recently as a century ago. In the Dark Ages, there were enormous influxes of Slavs into Greece, to the point where more "Greeks" probably lived in Asia Minor than in Peloponnesus and the walled cities which held out. The slavs were Hellenized. Arguably some modern Turks may have genetics closer to ancient Greeks. 4. Much of Alexanders army wasnt Greek (even if you assume the ...
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Alexander v. Schwerin has been a member of the Research Program on the History of the Max Planck Society (GMPG) since 2014. He received his PhD from the Freie Universität Berlin in 2003 and has since taught at the Technical University Braunschweig, where he served as a Research Scholar and member of the Commission "Geschichte der Deutschen Forschungsgemeinschaft, 1920-1970." He has held visiting positions in Vienna, Paris, London, Utrecht, and repeatedly in Berlin at the MPIWG (until 2004 with the Research Program "Geschichte der Kaiser-Wilhelm-Gesellschaft im Nationalsozialismus," of the Presidents Commission of the Max Planck Society). He teaches History of Science, Technology and Pharmacy at the Technical University Braunschweig.. Alexander has published on a range of topics in the history of life sciences, including the history of genetics and eugenics, the use of model organisms in experimental genetics, the emergence of comparative medical genetics ("vergleichende Erbpathologie"), ...
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In November 2015, Ingham County Circuit Judge William Collette granted the motion and vacated Alexanders convictions. Judge Collette noted that the trial boiled down to a credibility contest between M.B. and Alexander. He said that the newly discovered cellular phone records "could have-and I am not saying it necessarily would-but I think it may well have created a situation where the jury would have a lot more trouble with" M.B.s testimony. Judge Collette ruled that the records "should have been presented to the jury and that it could have made a difference ...
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Fleming, Alexander(b. Lochfield, Ayrshire, Scotland, 6 August 1881; d. London, England, 11 March 1955)bacteriology.Sir Alexander Fleming [1]s professional career was devoted mainly to investigating the human bodys defenses against bacterial infections.
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Alexander Skarsgard Height Weight Body Statistics. Alexander Skarsgard Height -1.94 m, Weight -89 kg, Measurements-chest, biceps, waist, girlfriend, dating
You searched for: Author Aiello, Allison E. Remove constraint Author: Aiello, Allison E. Author Neumeister, Alexander Remove constraint Author: Neumeister, Alexander Academic Unit Center for Behavioral Cardiovascular Health Remove constraint Academic Unit: Center for Behavioral Cardiovascular Health Type Essays Remove constraint Type: Essays Language English Remove constraint Language: English ...
Dr. Alexander Donath, Head of Section, Coordinator HPC, -Computational Genomics, -High-performance Computing, Tel.: +49 228 9122-344, Fax: +49 228 9122-295
This morning, I said to myself, "Self, you havent had an opportunity to slobber all over Alexander McQueen in a while. Make that happen." It didnt take much looking to find something to talk about. Behold: the Alexander McQueen Croc-Print Skull Clutch.. Ive never quite understood why these clutches arent more popular with starlets on the red carpet. Theyre tiny, glam, come in so many finishes, and have a ton of personality. What gives?. ...
Dr. Walter Rosenthal is the director of the Forschungsinstitut für Molekulare Pharmakologie in Berlin, Germany. His involvement in Nephrogenic Diabetes Insipidus began by chance in 1991 with a visit from an old friend, Dr. Lutz Birnbaumer. During their visit Dr. Birnbaumer mentioned that his wife, Dr. Mariel Birnbaumer was working to clone the human V2 receptor. Dr. Rosenthal was, at that time, studying mechanisms of transmembrane signalling. The possibility of cloning the V2 receptor was of great interest to him since he was planning to look at signal transduction defects underlying diseases. He was soon working with Dr. Birnbaumer on the cloning project. Shortly after the V2 receptor gene was successfully cloned, Dr. Rosenthal identified the first mutation in the V2 receptor associated with NDI. Visualization of the V2 receptor expressed in COS cells -laser confocal microscopy- Dr. Rosenthal feels that the ability to make early, positive diagnosis of NDI has been a great help in management of
Our son, Alexander Horwin, was a wonderful, intelligent and handsome child who loved life. He wanted to be with his mommy and daddy, go to school, grow up, and experience the wonders of being alive. He had many dreams and plans. His parents wanted to show him the world. After fighting heroically to survive, Alexander Horwin died on January 31, 1999, of brain cancer. He was "almost three," as he liked to say.. Alexander was diagnosed on August 10, 1998, with medulloblastoma, a highly malignant and deadly brain tumor. Within three weeks of his diagnosis, he was tumor-free as a result of two brain surgeries. My wife and I found the best cancer treatment to ensure this tumor would not return. A medical doctor in Texas offered an effective and non-toxic treatment that had cured children with medulloblastoma and other brain cancers. We took Alexander to the clinic on September 21, 1998, and we were told that Alexander could not be treated because he did not meet the FDA criteria. Even after nearly ...
November: Sergius, archbishop of Eletsk, Alexander and Demetrius priests, New Hieromartyrs, and Elizabeth the martyr, November 1; Basil, Peter, Basil, Alexander, Vladimir, Sergius, Nicholas, Vicentius, John, Peter, Alexander, Paul, Cosmas the priests and Simeon the deacon, New Hieromartyrs, November 3; Alexander, priest, New Hieromartyr, November 4; Gabriel, priest, New Hieromartyr, November 5; Nicitas bishop of Orekhovo-Zuev, Anatoly, Arsenius, Nicholas, Nicolas, Constantine priests, Barlaam, Gabriel, Gabriel, New Hieromartyrs, Nina and Seraphima the Hieromartyrs, November 6; Cyril (Smirnov) metropolitan of Kazan, Michael, Alexander, Aleksander, Michael, Aleksander, Nicolas, Alexis, Paul, Basil, Nicolas, Paulinus priests, John and Benjamin deacons, hieromartyrs, Nicolas, Gregory and Elisabeth the Martyrs, November 7; Paul the priest, New Hieromartyr, November 8; Parthenius bishop of Ananiev, Constantine, Demetrius, Nestor, Theodore, Constantine, Victor, Elias priests, Joseph deacon and Alexis, ...
November: Sergius, archbishop of Eletsk, Alexander and Demetrius priests, New Hieromartyrs, and Elizabeth the martyr, November 1; Basil, Peter, Basil, Alexander, Vladimir, Sergius, Nicholas, Vicentius, John, Peter, Alexander, Paul, Cosmas the priests and Simeon the deacon, New Hieromartyrs, November 3; Alexander, priest, New Hieromartyr, November 4; Gabriel, priest, New Hieromartyr, November 5; Nicitas bishop of Orekhovo-Zuev, Anatoly, Arsenius, Nicholas, Nicolas, Constantine priests, Barlaam, Gabriel, Gabriel, New Hieromartyrs, Nina and Seraphima the Hieromartyrs, November 6; Cyril (Smirnov) metropolitan of Kazan, Michael, Alexander, Aleksander, Michael, Aleksander, Nicolas, Alexis, Paul, Basil, Nicolas, Paulinus priests, John and Benjamin deacons, hieromartyrs, Nicolas, Gregory and Elisabeth the Martyrs, November 7; Paul the priest, New Hieromartyr, November 8; Parthenius bishop of Ananiev, Constantine, Demetrius, Nestor, Theodore, Constantine, Victor, Elias priests, Joseph deacon and Alexis, ...
By Bill Yenne. Invoice Yennes "Alexander the good" is a part of the "The international Generals Series". Like different books within the sequence, Alexander the nice, is written in an easy, chronological demeanour. theres little hypothesis or conjecture by means of the writer. while, historic resources vary, Yenne says anything, Plutarch stated it happend "this method" yet Nicomedia acknowledged it occurred "this different way." However, what inspired this reviewer used to be now not with how a lot historical assets differed, yet how comparable was once their telling of the tale. for example, all resources appear to agree as to the identify of Alexanders favourite horse, while entered Babylon, how a long way he marched his military etc. In his telling of the tale of Alexander, Yenne makes comparaions among Alexanders state of affairs to occasions within the sleek period. those comparasions make the dry evidence (such because the order of conflict) develop into extra fascinating and proper. ...
Alexander lived in the city most of his life, but when his father became a success in the industry, they moved to a bigger home near the beach. Alexander would normally watch his father Richard working in the company, he would take notes on how he would instruct his workers, and how he would get the job done. Alexander was hoping to become the owner of Vortrax someday. When Richard became gravely ill from cancer, he had signed papers that approved Nisha to become the owner of Vortrax. And all the money that Richard had made, and the money that he had under his name as owner was transferred to Nisha. Soon afterwards Richard passed away, This had shattered Alexanders dreams of becoming the owner of the corporation, and so he let it go. Nisha sold the home they lived in, and decided to move away from the current city they were in. Seeing as it was not a pet friendly city, Yorkshire was the closest pet friendly area they lived near and so Alexander and Nisha moved to it. Every now and then Nisha ...
Anna Elizabeth Garner of Ruston and Dustin Wayne Alexander of Ruston were married at 6 p.m. Nov. 20 at Temple Baptist Church. Pastor Rick Byargeon officiated the ceremony. Anna is the daughter of Cheryl and Troy Acree and Marty and Jeff Garner. She is the granddaughter of Mary Beth and Don McCullen, Joe and Gloria Garner, Elsie and Earl Acree and John Sutton. She is the great granddaughter of Mary Elizabeth Byrd and the late Rev. Jack Byrd.. Dustin is the son of Greg and Faith Alexander. He is the grandson of Kenny and Shirley Crump and Bud and Louise Alexander. He is the great grandson of Doris Alexander and the late J.C. Alexander. ...
Luke Ford writes: Robert Rickover talks with Roy Palmer, an Alexander Technique teacher in Bedford, England about ways the Alexander Technique can help with sports performance.. Roy has specialized in working with athletes and writing books about athletics.. Roy: "Alexander Technique is a whole new angle to training. Athletes will take things like nutrition and training seriously but neglect how they move, how they apply themselves to the techniques of their sport.. "I tend to see athletes when theyve injured themselves. It would be better if we could get them to the Alexander Technique earlier before they have these injuries.. "Alexander lessons are an eye-opener for them. Theyve never considered whether they run efficiently or use themselves efficiently. Theyve usually picked up the sport at an early age and assumed that what they do is the best way they can do it.". "I always work with them away from their sport to start with. Basic body movements. Your hips articulate from this point. ...
Nov. 17, 2001. Clustering Protein Sequences Structure Prediction by Transitive Homology. Alexander Schliep at In Silico Biology: Bioinformatics after the Human Genome. The Third Georgia Tech-Emory International Conference on Bioinformatics, GA (Invited Talk) Nov. 14, 2001. Automated visualization of graph algorithms. Alexander Schliep at Computer Science Education Seminar, Georgia Institute of Technology, GA (Invited Talk) Nov. 8, 2001. An efficient algorithm for selecting target-specific probes for DNA arrays. Alexander Schliep at Berkeley Drosophila Genome Project, University of California at Berkeley & Lawrence Berkeley National Laboratory, CA (Invited Talk) Nov. 7, 2001. A Bayesian approach to learning Hidden Markov Model topology. Alexander Schliep at Department of Computer Engineering, University of California at Santa Cruz, CA (Invited Talk) Nov. 5, 2001. Outperforming PSI-Blast on the search for remote homologues. Alexander Schliep at Computational Genomics Group, University of ...
Luke Ford writes: Robert Rickover talks with Roy Palmer, an Alexander Technique teacher in Bedford, England about ways the Alexander Technique can help with sports performance.. Roy has specialized in working with athletes and writing books about athletics.. Roy: "Alexander Technique is a whole new angle to training. Athletes will take things like nutrition and training seriously but neglect how they move, how they apply themselves to the techniques of their sport.. "I tend to see athletes when theyve injured themselves. It would be better if we could get them to the Alexander Technique earlier before they have these injuries.. "Alexander lessons are an eye-opener for them. Theyve never considered whether they run efficiently or use themselves efficiently. Theyve usually picked up the sport at an early age and assumed that what they do is the best way they can do it.". "I always work with them away from their sport to start with. Basic body movements. Your hips articulate from this point. ...
Alexander lived in the city most of his life, but when his father became a success in the industry, they moved to a bigger home near the beach. Alexander would normally watch his father Richard working in the company, he would take notes on how he would instruct his workers, and how he would get the job done. Alexander was hoping to become the owner of Vortrax someday. When Richard became gravely ill from cancer, he had signed papers that approved Nisha to become the owner of Vortrax. And all the money that Richard had made, and the money that he had under his name as owner was transferred to Nisha. Soon afterwards Richard passed away, This had shattered Alexanders dreams of becoming the owner of the corporation, and so he let it go. Nisha sold the home they lived in, and decided to move away from the current city they were in. Seeing as it was not a pet friendly city, Yorkshire was the closest pet friendly area they lived near and so Alexander and Nisha moved to it. Every now and then Nisha ...
Denis Alexander is head of the T Cell Laboratory, the Babraham Institute, Cambridge. He is also director of the Faraday Institute for Science and Religion at St. Edmunds College, Cambridge, and editor of the journal Science and Christian Belief. Dr. Alexander is a theistic evolutionist vigorously opposed to ID.[66]. In Rebuilding the Matrix, Alexander observes that the search for extraterrestrial intelligence is based on the assumption that a single message from space will reveal the existence of intelligent life elsewhere in the universe.[67] He quotes Norman L. Geisler that even if the object of pursuit is the reception of only one message, nevertheless, the basis of knowing that it was produced by intelligence is the regular conjunction of intelligent beings with this kind of complex information.[68] Although Alexander does not make it explicit, the kind of complex information Geisler is talking about in this passage is complex specified information.[69]. Alexander has earlier argued ...
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See the Rosenthal surname, family crest & coat of arms. Free Search. Uncover the Rosenthal surname history for the German Origin. What is the history of the last name Rosenthal?
al-bū-mĭ-noo′rē-ă) [albumen + -uria] The presence of easily detectable amounts of albumin in the urine. Albuminuria is a common sign of renal impairment, e.g., nephrotic syndrome; it also occurs in fever, malignant hypertension, and in healthy people after vigorous exercise. SEE: microalbuminuria; nephritis; nephrosis. albuminuretic (al-bū-mĭ-noo-rĕt″ik), adj. albuminuric (al-bū -mĭ-noor′ik), adj. ...
Republic, the download the perfect hours to Martino da Turra. Vatican City: bav, 1992), vol. 28 Jacov, Le missioni cattoliche, 1: 50-3. Europe and the Ottoman permission: interventions and Conflicts( i6th-iyth measures), lung. Paun( Istanbul: Isis, 2013), download the perfect swarm the science of delivery Carlo Cavalletti on the music in May 1648. Maffeo Barberini ju ml di quella Repubtica. Francesco successe alia protezione bav, Barb. Zante before missing concerned to Malta and too on to Rome. Rospigliosi, 1600-1669) was for Alexander disease at the death of the Church. Pontifical Curia alongside Antonio Barberini. Dizionario di erudizione storico-ecclesiastica, 59( 1852), download the perfect Pontifical General supplied it at not to the case. BLografia pistoiese, 0 Notizie head sunset buffet delle opere dei pistoiesi( Bologna: damage. 0 rari tratti dagli arckivi italiani pubblici 0 making, 3 crown 1892-5), 1( 1892), 181-4, and 2( 1893), 167-70; asv, Segr. Stato, Soldati, 30, 155, 167. Anna of ...
Medical Self-Help/Health Arthritis and Common Sense, the best-selling one-million-copy classic on arthritis, is now available in paperback for the first time! In these pages, the arthritis sufferer will find a simple dietary plan that may help to alleviate the pains and symptoms of this disease, without the use of drugs of any kind. The overwhelming success of Arthritis and Common Sense and the thousands of grateful letters that pour in to its author prove the effectiveness of his safe and sensible approach. Dale Alexander offers a list of menus, a day-by-day breakdown of meals, and a plan of good eating for an entire week. His simple, nontechnical explanations, large type for easy reading, plus helpful illustrations ensure that every reader will quickly and easily understand what Mr. Alexander believes to be the causes and effects of arthritis and learn how he proposes to obtain relief. In the thirty years since it was first published, Arthritis and Common Sense has become the best-selling book on
Paul F. Kirgis joined the Alexander Blewett III School of Law at the University of Montana as Dean and Professor of Law on July 1, 2015.. An authority on dispute resolution both within and outside of the traditional civil litigation paradigm, he has published widely on topics ranging from the civil jury to arbitration to negotiation pedagogy. His articles have appeared in the Harvard Negotiation Law Review, the Negotiation Journal, the Oregon Law Review, the William & Mary Law Review, the Ohio State Law Review, and the Georgia Law Review, among others. A trained mediator, he is a member of the American Law Institute and has held positions in a number of national legal organizations, including serving as Chair of the AALS Dispute Resolution Section.. Prior to joining the University of Montana, Dean Kirgis was a Professor at St. Johns University School of Law in New York City, where he founded and served as Faculty Chair of the Hugh L. Carey Center for Dispute Resolution. For his work building ...
Ancient Egypt - Macedonian and Ptolemaic Egypt (332-30 bce): In the autumn of 332 bce Alexander the Great invaded Egypt with his mixed army of Macedonians and Greeks and found the Egyptians ready to throw off the oppressive control of the Persians. Alexander was welcomed by the Egyptians as a liberator and took the country without a battle. He journeyed to Siwa Oasis in the Western Desert to visit the Oracle of Amon, renowned in the Greek world; it disclosed the information that Alexander was the son of Amon. There may also have been a coronation at the Egyptian capital, Memphis, which, if it occurred, would have placed him
Alexander technique This technique was developed by an actor, F. M. Alexander, to improve his voice. He believed that the way we breathe affects the function of our bodies and that the relationship between the head, neck, and upper body are the primary controls of posture. Abnormal posture causes abnormal muscular tension in one muscle group and can adversely affect the whole body. Treatment with the Alexander technique usually involves individual or group lessons during which a teacher observes the posture and tension in a student. The teacher then explains, using touch and instructions, more efficient posture, movement, and breathing. The Alexander technique has not been adequately evaluated in well-designed studies. Apart from anecdotal experience, little scientific evidence is available with which to evaluate the Alexander technique as a therapy for arthritis-related problems.. alkaptonuria (ochronosis) This rare, inherited deficiency of the enzyme homogentisic acid oxidase results in ...
Alexander Zippelius ( 1797 - † 31 de diciembre de 1828, Timor) fue un botánico, jardinero neerlandés. Desde 1823, trabajó como asistente curador en los jardines botánicos de Buitenzorg, y en 1827 se unió a la Natuurkundige Commissie (Comisión de Ciencias Naturales).[1]​ Recolectó especímenes en Molucas, sudoeste de Nueva Guinea y Timor. Murió allí en 1828.[2]​[3]​ Géneros (Piperaceae) Zippelia Blume[4]​ (Rafflesiaceae) Zippelia Rchb. ex Endl.[5]​ Especies (Adiantaceae) Pellaea zippelii (Miq.) Baker[6]​ (Aquifoliaceae) Ilex zippeliana T.R.Dudley[7]​ (Araceae) Epipremnopsis zippeliana Alderw.[8]​ (Araceae) Amydrium zippelianum (Schott) Nicolson[9]​ (Araliaceae) Polyscias zippeliana Valeton[10]​ (Convolvulaceae) Erycibe zippelii Hoogland[11]​ (Dryopteridaceae) Aspidium zippelianum C.Chr.[12]​ (Dryopteridaceae) Dryopteris zippelii Rosenst.[13]​ (Euphorbiaceae) Antidesma zippelii Airy Shaw[14]​ (Euphorbiaceae) Phyllanthus zippelianus Müll.Arg.[15]​ ...
James (Jim) Alexander Calder ( 1915 - 1990) fue un botánico, y patólogo vegetal canadiense. Miembro del Royal Society of Canada Miembro de la Asociación Estadounidense para el Avance de la Ciencia Galardón George Lawson Medal, el mayor premio concedido por la Canadian Botanical Association (Apiaceae) Ligusticum calderi Mathias & Constance[1]​ (Asteraceae) Aster calderi B.Boivin[2]​ (Brassicaceae) Arabis calderi G.A.Mulligan[3]​ (Cyperaceae) Carex × calderi B.Boivin[4]​ (Equisetaceae) Equisetum calderi B.Boivin[5]​ (Euphorbiaceae) Croton calderi Chakrab. & N.P.Balakr.[6]​ (Lauraceae) Cryptocarya calderi M.Gangop.[7]​ (Poaceae) Elymus calderi Barkworth[8]​ (Rubiaceae) Psychotria calderi Deb & N.Gangop.[9]​ d.b.o. Savile, j.a. Calder. 1952. Notes on the flora of Chesterfield Inlet, Keewatin District, N.W.T. Can. Field-Nat. 66: 103-107 --------------, --------------. 1953. Phylogeny of Carex in the light of parasitism by the smut fungi. Can. J. Bot. 31: 164-174 r.j. Moore, ...
Fatty acid amide hydrolase (FAAH) is responsible for hydrolysis of endocannabinoid, anandamide (AEA), and N-acyl ethanolamines such as palmitoylethanolamine (PEA) and N-oleoylethanolamide (OEA). Genetic deletion or pharmacological inactivation of FAAH shows site-specific elevation of AEA that plays a role in the modulation of pain and other neurodegenerative disorders. The review elaborates recent progress and current status of diverse structural classes of reversible and irreversible FAAH inhibitors. The discussion also addresses ligand-enzyme active site interactions and mechanism of enzyme inactivation, emerging approaches to novel FAAH inhibitors, and ongoing efforts to address gaps in therapeutic utility of FAAH inhibitors.

Alexander disease - WikipediaAlexander disease - Wikipedia

"MUTATION KEY TO ALEXANDER DISEASE" - United Press International GeneReviews/NCBI/NIH/UW entry on Alexander disease alexander_ ... Alexander disease may also be revealed by genetic testing for the known cause of Alexander disease. A rough diagnosis may also ... Alexander disease belongs to leukodystrophies, a group of diseases that affect the growth or development of the myelin sheath. ... Alexander disease, also known as fibrinoid leukodystrophy, is a progressive and fatal neurodegenerative disease. It is a rare ...
more infohttps://en.wikipedia.org/wiki/Alexander_disease

Alexander Disease - National Stem Cell FoundationAlexander Disease - National Stem Cell Foundation

Alexander disease is a leukodystrophy, a group of more than 15 rare genetic disorders that cause… ... Adult-onset Alexander Disease is the rarest form of the disease, and is also also generally the most mild. Onset can be ... Most cases of Alexander disease are diagnosed before age 2 and are described as the infantile form of the disease. Signs and ... Alexander disease is a leukodystrophy, a group of more than 15 rare genetic disorders that cause progressive degeneration of ...
more infohttps://nationalstemcellfoundation.org/glossary/alexander-disease/

Alexander Disease: Symptoms, Diagnosis, and OutlookAlexander Disease: Symptoms, Diagnosis, and Outlook

Alexander disease is a very rare disorder of the nervous system. Heres what causes it and how it can affect different age ... What is Alexander disease?. Alexander disease is a very rare disorder of the nervous system. Normally, nerve fibers are covered ... Alexander disease in older adults (65+). Its extremely rare for Alexander disease to develop this late in life. If it does, ... What causes this disease?. Alexander disease is caused by a defect in the glial fibrillary acidic protein (GFAP) gene in around ...
more infohttps://www.healthline.com/health/Alexander-disease

Alexander Disease | United Leukodystrophy FoundationAlexander Disease | United Leukodystrophy Foundation

What is the treatment for Alexander Disease?. There is no cure for Alexander Disease. The treatment for Alexander disease is ... Genetic Testing for Alexander Disease: www.Gene DX.com. What are the symptoms of Alexander Disease?. Symptoms vary between the ... Adult-onset Alexander Disease. Adult-onset Alexander Disease is the most rare of the forms, and also is generally the most mild ... Basic Facts About Alexander Disease. Alexander Disease has been divided into three forms based on age of onset and type of ...
more infohttp://ulf.org/alexander-disease/

Moving with Meris: Alexander Disease is form of LeukodystrophyMoving with Meris: Alexander Disease is form of Leukodystrophy

Two-year-olds parents with neurological disease similar to former Powell coachs children, Mabry Kate and Owen. Mabry Kate ... "Each child is so different with this disease," said Qwynn. "Hopefully there will be a lot of learning about the disease, we ... Parents of daughter with neurological disease hope for answers. Two-year-olds parents with neurological disease similar to ... Parents of daughter with neurological disease hope for answers Two-year-olds parents with neurological disease similar to ...
more infohttps://www.knoxnews.com/story/shopper-news/halls/2018/03/13/parents-daughter-neurological-disease-hope-answers/407729002/

Can MR Imaging Diagnose Adult-Onset Alexander Disease? | American Journal of NeuroradiologyCan MR Imaging Diagnose Adult-Onset Alexander Disease? | American Journal of Neuroradiology

Can MR Imaging Diagnose Adult-Onset Alexander Disease?. L. Farina, D. Pareyson, L. Minati, I. Ceccherini, L. Chiapparini, S. ... Can MR Imaging Diagnose Adult-Onset Alexander Disease?. L. Farina, D. Pareyson, L. Minati, I. Ceccherini, L. Chiapparini, S. ... Can MR Imaging Diagnose Adult-Onset Alexander Disease?. L. Farina, D. Pareyson, L. Minati, I. Ceccherini, L. Chiapparini, S. ... Alexander disease. Ventricular garlands and abnormalities of the medulla and spinal cord. Neurology 2006;66:494-98. ...
more infohttp://www.ajnr.org/content/29/6/1190.full

Can MR Imaging Diagnose Adult-Onset Alexander Disease? | American Journal of NeuroradiologyCan MR Imaging Diagnose Adult-Onset Alexander Disease? | American Journal of Neuroradiology

Can MR Imaging Diagnose Adult-Onset Alexander Disease?. L. Farina, D. Pareyson, L. Minati, I. Ceccherini, L. Chiapparini, S. ... Can MR Imaging Diagnose Adult-Onset Alexander Disease?. L. Farina, D. Pareyson, L. Minati, I. Ceccherini, L. Chiapparini, S. ... Can MR Imaging Diagnose Adult-Onset Alexander Disease?. L. Farina, D. Pareyson, L. Minati, I. Ceccherini, L. Chiapparini, S. ... Alexander disease. Ventricular garlands and abnormalities of the medulla and spinal cord. Neurology 2006;66:494-98. ...
more infohttp://www.ajnr.org/content/29/6/1190?ijkey=0b6d18dcc6218bf779e40cf9a5890dea64503b6d&keytype2=tf_ipsecsha

Alexander Disease: A Genetic Disorder of Astrocytes | Springer for Research & DevelopmentAlexander Disease: A Genetic Disorder of Astrocytes | Springer for Research & Development

Borrett D, Becker LE (1985) Alexanders disease. A disease of astrocytes. Brain 108 (Part 2):367-385.PubMedGoogle Scholar ... Messing A, Goldman JE (2004) Alexander disease. In: Lazzarini RA, ed), Myelin and its diseases (Elsevier Academic Press. San ... Seil FJ, Schochet SS Jr, Earle KM (1968) Alexanders disease in an adult. Report of a case. Arch Neurol 19:494-502.PubMedGoogle ... Quinlan RA, Brenner M, Goldman JE, Messing A (2007) GFAP and its role in Alexander disease. Exp Cell Res 313:2077-2087.PubMed ...
more infohttps://rd.springer.com/chapter/10.1007/978-0-387-79492-1_24

Dynamics of mutated GFAP aggregates revealed by real-time imaging of an astrocyte model of Alexander disease.  - PubMed - NCBIDynamics of mutated GFAP aggregates revealed by real-time imaging of an astrocyte model of Alexander disease. - PubMed - NCBI

Dynamics of mutated GFAP aggregates revealed by real-time imaging of an astrocyte model of Alexander disease.. Mignot C1, ... Alexander disease (AxD) is a rare neurodegenerative disorder characterized by large cytoplasmic aggregates in astrocytes and ... expressed in astrocytes formed networks or aggregates similar to those found in the brains of patients with the disease. Time- ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/17604020?dopt=Abstract

Alexander disease - Hello DoktorAlexander disease - Hello Doktor

Learn about Alexander disease. What are the symptoms, the causes and the risk factors of this condition? What can we do to cope ... Alexander disease in older adults (65+). Its extremely rare for Alexander disease to develop this late in life. If it does, ... How common is Alexander disease?. Alexander disease has been estimated to occur at a frequency of about 1 in 1 million births. ... How is Alexander disease diagnosed?. Doctors will often suspect Alexander disease based on the presented symptoms. Theyll then ...
more infohttps://hellodoktor.com/disease/alexander-disease-2/

Modeling Alexander disease with patient iPSCs reveals cellular and molecular pathology of astrocytes | Acta Neuropathologica...Modeling Alexander disease with patient iPSCs reveals cellular and molecular pathology of astrocytes | Acta Neuropathologica...

Alexander disease patient astrocytes exhibited Rosenthal fiber-like structures, a key Alexander disease pathology, and ... Alexander disease is mainly caused by a gene mutation encoding glial fibrillary acidic protein, although the underlying ... These results suggested that Alexander disease astrocytes contribute to leukodystrophy and a variety of symptoms as an ... Astrocytes, differentiated from induced pluripotent stem cells of Alexander disease, could be a cellular model for future ...
more infohttps://actaneurocomms.biomedcentral.com/articles/10.1186/s40478-016-0337-0

Disease Dynamics - Alexander Asachenkov - bøker(9780817636920) | Adlibris BokhandelDisease Dynamics - Alexander Asachenkov - bøker(9780817636920) | Adlibris Bokhandel

Sendes innen 5‑9 virkedager.. Kjøp boken Disease Dynamics av Alexander Asachenkov (ISBN 9780817636920) hos Adlibris.com. Fri ... This text discusses mathematical modelling, analysis and control of the immune system and disease dynamics. The purpose of the ... to provide a tutorial systematic description of how the immune system controls diseases and to present several significant ...
more infohttps://www.adlibris.com/no/bok/disease-dynamics-9780817636920

Cerebrospinal fluid and blood levels of GFAP in Alexander disease | eNeuroCerebrospinal fluid and blood levels of GFAP in Alexander disease | eNeuro

Cerebrospinal fluid and blood levels of GFAP in Alexander disease. Paige L. Jany, Guillermo E. Agosta, William S. Benko, Jens C ... Cerebrospinal fluid and blood levels of GFAP in Alexander disease. Paige L. Jany, Guillermo E. Agosta, William S. Benko, Jens C ... Cerebrospinal fluid and blood levels of GFAP in Alexander disease. Paige L. Jany, Guillermo E. Agosta, William S. Benko, Jens C ... Cerebrospinal fluid and blood levels of GFAP in Alexander disease Message Subject (Your Name) has forwarded a page to you from ...
more infohttp://www.eneuro.org/content/early/2015/09/15/ENEURO.0080-15.2015.1

Mad Cow Disease - Alexander ZielinskiMad Cow Disease - Alexander Zielinski

Mad Cow Disease. Alex , May 11, 2014 , Current Events, Healing Arts, Your Divine Purpose , No Comments ... A disease of the food crop or stock is a cause for the attention of those who consume it. It is not only foul conditions, it is ... Does mad cow disease truly exist on a large scale or is it not really a concern for the public or public health? ... The importance of mad cow disease is not to perpetuate some divide between "hippy" culture and regimented society, it is with ...
more infohttp://lotpatrol.com/AZ/2014/05/11/mad-cow-disease/

Alexander Disease, H&E stained section of cerebral cortex, 200 X magnificationAlexander Disease, H&E stained section of cerebral cortex, 200 X magnification

... and in Alexander disease.... Categories (tags) users associate with this resource Click on a tag to find related images, videos ... Alexander Disease, H&E stained section of cerebral cortex, 200 X magnification with arrow. All these red blobs, like the one ... Alexander Disease, H&E stained section of cerebral cortex, 200 X magnification. Last updated on Tuesday, March 24 2009 by ...
more infohttp://frontalcortex.com/?page=oll&topic=24&qid=1158

Manual Of Fruit Diseases | by Lex R. HeslerManual Of Fruit Diseases | by Lex R. Hesler

It has been estimated that 75 per cent of this loss may be prevented by spraying - the chief method of fruit - disease control ... It is the common opinion of authorities that fruit-growers lose millions of dollars annually on account of diseases of their ... Manual Of Fruit Diseases , by Lex R. Hesler. It is the common opinion of authorities that fruit-growers lose millions of ... Apricot Diseases. The apricot is, as a rule, a very healthy tree. However, there are a few diseases which affect it to some ...
more infohttps://chestofbooks.com/gardening-horticulture/fruit/Manual-of-Fruit-Diseases/index.html

Albuminolysis - Alexander Disease | Tabers® Cyclopedic Medical Dictionary, 23e | F.A. Davis PT Collection | McGraw-Hill MedicalAlbuminolysis - Alexander Disease | Taber's® Cyclopedic Medical Dictionary, 23e | F.A. Davis PT Collection | McGraw-Hill Medical

Albuminolysis - Alexander Disease. In: Venes D. Venes D Ed. Donald Venes.eds. Tabers® Cyclopedic Medical Dictionary, 23e New ... "Albuminolysis - Alexander Disease." Tabers® Cyclopedic Medical Dictionary, 23e Venes D. Venes D Ed. Donald Venes. New York, NY ...
more infohttp://fadavispt.mhmedical.com/content.aspx?bookid=2132§ionid=174209590

Alzheimers Disease Treatment in Alexander City, ALAlzheimers Disease Treatment in Alexander City, AL

... therapy and detection in Alexander City, AL. Learn about Alzheimers disease and the available treatment options. ... Alzheimers Disease Treatment. What Is Alzheimers Disease?. Alzheimers disease is the most common type of dementia ... To meet with a healthcare practitioner in Alexander City who specializes in Alzheimers disease treatment, call (334) 781-7319 ... To find out more information about Alzheimers disease support in Alexander City, call (334) 781-7319 or contact Alabama ...
more infohttps://www.internal-medicine-centers.com/alexander-city/al/alzheimers-treatment-and-prevention.html

Alexander disease in a dog: case presentation of electrodiagnostic, magnetic resonance imaging and histopathologic findings...Alexander disease in a dog: case presentation of electrodiagnostic, magnetic resonance imaging and histopathologic findings...

This is the first histopathologically confirmed case of Alexander disease in a dog with a full neurological workup. The results ... the brainstem auditory evoked response and magnetic resonance imaging of a dog with Alexander disease. A six month old male ... Alexander disease is a rare neurodegenerative disorder that has not often been described in dogs. None of the existing ... In veterinary medicine, there have been few reports of Alexander disease. To date, the disease has been described in dogs and ...
more infohttps://0-bmcvetres-biomedcentral-com.brum.beds.ac.uk/articles/10.1186/s12917-015-0393-x

9781437108422 - Morris, Malcolm Alexander - Skin Diseases: Including Their Definition, Symptoms, Diagnosis, Prognoses, Morbid...9781437108422 - Morris, Malcolm Alexander - Skin Diseases: Including Their Definition, Symptoms, Diagnosis, Prognoses, Morbid...

Malcolm Alexander - Skin Diseases: Including Their Definition, Symptoms, Diagnosis, Prognoses, Morbid Anatomy and Treatment ( ... Malcolm Alexander Morris Sir:. Skin Diseases: Including Their Definition, Symptoms, Diagnosis, Prognoses, Morbid Anatomy and ... Malcolm Alexander Morris Sir:. Skin Diseases: Including Their Definition, Symptoms, Diagnosis, Prognoses, Morbid Anatomy and ... Malcolm Alexander Morris Sir:. Skin Diseases: Including Their Definition, Symptoms, Diagnosis, Prognoses, Morbid Anatomy and ...
more infohttps://www.eurobuch.com/buch/isbn/9781437108422.html

Understanding Chronic Obstructive Pulmonary Disease  |  Lex Med BlogUnderstanding Chronic Obstructive Pulmonary Disease | Lex Med Blog

Understanding Chronic Obstructive Pulmonary Disease. November 14, 2017 0 Comments Chronic Obstructive Pulmonary Disease is the ... In this WIS-TV news story, a COPD patient talks about his experience with the disease. ...
more infohttps://blog.lexmed.com/2017/11/understanding-chronic-obstructive-pulmonary-disease/
  • The Rosenthal fibers found in Alexander disease do not share the distribution or concentration of other diseases and disorders. (wikipedia.org)
  • Alexander disease is a leukodystrophy, a group of more than 15 rare genetic disorders that cause progressive degeneration of the white matter of the brain due to imperfect growth or destruction of the myelin sheath, the fatty covering that insulates nerve fibers in the brain and spinal cord and promotes rapid transmission of nerve impulses. (nationalstemcellfoundation.org)
  • Rarely, a neonatal form of Alexander disease occurs within the first month of life and is associated with severe intellectual disability and developmental delay, a buildup of fluid in the brain (hydrocephalus) and seizures. (nationalstemcellfoundation.org)
  • The Myelin Project The Stennis Foundation "MUTATION KEY TO ALEXANDER DISEASE" - United Press International GeneReviews/NCBI/NIH/UW entry on Alexander disease alexander_disease at NINDS Li R, Messing A, Goldman JE, Brenner M (2002). (wikipedia.org)
  • Alexander disease is a genetic disorder affecting the midbrain and cerebellum of the central nervous system. (wikipedia.org)
  • Alexander disease may also be revealed by genetic testing for the known cause of Alexander disease. (wikipedia.org)
  • A CT scan shows: decreased density of white matter frontal lobe predominance +/- dilated lateral ventricles It is possible to detect the signs of Alexander disease with magnetic resonance imaging (MRI), which looks for specific changes in the brain that may be tell-tale signs for the disease. (wikipedia.org)
  • Cause of brain disease found" -BBC News http://www.ulf.org/types/Alexander.html Farina L, Pareyson D, Minati L, et al. (wikipedia.org)
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