A nonhormonal medication for the treatment of postmenopausal osteoporosis in women. This drug builds healthy bone, restoring some of the bone loss as a result of osteoporosis.
Agents that inhibit BONE RESORPTION and/or favor BONE MINERALIZATION and BONE REGENERATION. They are used to heal BONE FRACTURES and to treat METABOLIC BONE DISEASES such as OSTEOPOROSIS.
Metabolic disorder associated with fractures of the femoral neck, vertebrae, and distal forearm. It occurs commonly in women within 15-20 years after menopause, and is caused by factors associated with menopause including estrogen deficiency.
A diphosphonate which affects calcium metabolism. It inhibits ectopic calcification and slows down bone resorption and bone turnover.
Organic compounds which contain P-C-P bonds, where P stands for phosphonates or phosphonic acids. These compounds affect calcium metabolism. They inhibit ectopic calcification and slow down bone resorption and bone turnover. Technetium complexes of diphosphonates have been used successfully as bone scanning agents.
The amount of mineral per square centimeter of BONE. This is the definition used in clinical practice. Actual bone density would be expressed in grams per milliliter. It is most frequently measured by X-RAY ABSORPTIOMETRY or TOMOGRAPHY, X RAY COMPUTED. Bone density is an important predictor for OSTEOPOROSIS.
Reduction of bone mass without alteration in the composition of bone, leading to fractures. Primary osteoporosis can be of two major types: postmenopausal osteoporosis (OSTEOPOROSIS, POSTMENOPAUSAL) and age-related or senile osteoporosis.
The continuous turnover of BONE MATRIX and mineral that involves first an increase in BONE RESORPTION (osteoclastic activity) and later, reactive BONE FORMATION (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium HOMEOSTASIS. An imbalance in the regulation of bone remodeling's two contrasting events, bone resorption and bone formation, results in many of the metabolic bone diseases, such as OSTEOPOROSIS.
Breaks in bones.
A polypeptide that consists of the 1-34 amino-acid fragment of human PARATHYROID HORMONE, the biologically active N-terminal region. The acetate form is given by intravenous infusion in the differential diagnosis of HYPOPARATHYROIDISM and PSEUDOHYPOPARATHYROIDISM. (Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Englewood, CO, 1995)
Fractures of the femur.
Bone loss due to osteoclastic activity.
The longest and largest bone of the skeleton, it is situated between the hip and the knee.
Broken bones in the vertebral column.
A specialized CONNECTIVE TISSUE that is the main constituent of the SKELETON. The principle cellular component of bone is comprised of OSTEOBLASTS; OSTEOCYTES; and OSTEOCLASTS, while FIBRILLAR COLLAGENS and hydroxyapatite crystals form the BONE MATRIX.
A second generation selective estrogen receptor modulator (SERM) used to prevent osteoporosis in postmenopausal women. It has estrogen agonist effects on bone and cholesterol metabolism but behaves as a complete estrogen antagonist on mammary gland and uterine tissue.
Hydroxy analogs of vitamin D 3; (CHOLECALCIFEROL); including CALCIFEDIOL; CALCITRIOL; and 24,25-DIHYDROXYVITAMIN D 3.
Fractures occurring as a result of disease of a bone or from some undiscoverable cause, and not due to trauma. (Dorland, 27th ed)
The most common form of fibrillar collagen. It is a major constituent of bone (BONE AND BONES) and SKIN and consists of a heterotrimer of two alpha1(I) and one alpha2(I) chains.
The second longest bone of the skeleton. It is located on the medial side of the lower leg, articulating with the FIBULA laterally, the TALUS distally, and the FEMUR proximally.
Drugs whose drug name is not protected by a trademark. They may be manufactured by several companies.
The spinal or vertebral column.
Removal of mineral constituents or salts from bone or bone tissue. Demineralization is used as a method of studying bone strength and bone chemistry.
VERTEBRAE in the region of the lower BACK below the THORACIC VERTEBRAE and above the SACRAL VERTEBRAE.
An enzyme involved in the MEVALONATE pathway, it catalyses the synthesis of farnesyl diphosphate from isopentenyl diphosphate and dimethylallyl diphosphate.
A diphosphonate which affects calcium metabolism. It inhibits bone resorption and soft tissue calcification.
The insertion of a tube into the stomach, intestines, or other portion of the gastrointestinal tract to allow for the passage of food products, etc.
Process by which organic tissue becomes hardened by the physiologic deposit of calcium salts.
Retinol and derivatives of retinol that play an essential role in metabolic functioning of the retina, the growth of and differentiation of epithelial tissue, the growth of bone, reproduction, and the immune response. Dietary vitamin A is derived from a variety of CAROTENOIDS found in plants. It is enriched in the liver, egg yolks, and the fat component of dairy products.
A country spanning from central Asia to the Pacific Ocean.
Pathological processes of the ENDOCRINE GLANDS, and diseases resulting from abnormal level of available HORMONES.
Those persons legally qualified by education and training to engage in the practice of pharmacy.
Water naturally or artificially infused with mineral salts or gases.
Raw and processed or manufactured milk and milk-derived products. These are usually from cows (bovine) but are also from goats, sheep, reindeer, and water buffalo.
Solid dosage forms, of varying weight, size, and shape, which may be molded or compressed, and which contain a medicinal substance in pure or diluted form. (Dorland, 28th ed)
Drugs that act locally on cutaneous or mucosal surfaces to produce inflammation; those that cause redness due to hyperemia are rubefacients; those that raise blisters are vesicants and those that penetrate sebaceous glands and cause abscesses are pustulants; tear gases and mustard gases are also irritants.
Liquids that are suitable for drinking. (From Merriam Webster Collegiate Dictionary, 10th ed)
A province of Canada, lying between the provinces of Alberta and Manitoba. Its capital is Regina. It is entirely a plains region with prairie in the south and wooded country with many lakes and swamps in the north. The name was taken from the Saskatchewan River from the Cree name Kisiskatchewani Sipi, meaning rapid-flowing river. (From Webster's New Geographical Dictionary, 1988, p1083 & Room, Brewer's Dictionary of Names, 1992, p486)
Tumors or cancer of the PROSTATE.
A gland in males that surrounds the neck of the URINARY BLADDER and the URETHRA. It secretes a substance that liquefies coagulated semen. It is situated in the pelvic cavity behind the lower part of the PUBIC SYMPHYSIS, above the deep layer of the triangular ligament, and rests upon the RECTUM.
The surgical removal of one or both testicles.
A glycoprotein that is a kallikrein-like serine proteinase and an esterase, produced by epithelial cells of both normal and malignant prostate tissue. It is an important marker for the diagnosis of prostate cancer.
Breaks in bones resulting from low bone mass and microarchitectural deterioration characteristic of OSTEOPOROSIS.
Fractures of the FEMUR HEAD; the FEMUR NECK; (FEMORAL NECK FRACTURES); the trochanters; or the inter- or subtrochanteric region. Excludes fractures of the acetabulum and fractures of the femoral shaft below the subtrochanteric region (FEMORAL FRACTURES).
A syndrome with overlapping clinical features of systemic lupus erythematosus, scleroderma, polymyositis, and Raynaud's phenomenon. The disease is differentially characterized by high serum titers of antibodies to ribonuclease-sensitive extractable (saline soluble) nuclear antigen and a "speckled" epidermal nuclear staining pattern on direct immunofluorescence.
A subacute or chronic inflammatory disease of muscle and skin, marked by proximal muscle weakness and a characteristic skin rash. The illness occurs with approximately equal frequency in children and adults. The skin lesions usually take the form of a purplish rash (or less often an exfoliative dermatitis) involving the nose, cheeks, forehead, upper trunk, and arms. The disease is associated with a complement mediated intramuscular microangiopathy, leading to loss of capillaries, muscle ischemia, muscle-fiber necrosis, and perifascicular atrophy. The childhood form of this disease tends to evolve into a systemic vasculitis. Dermatomyositis may occur in association with malignant neoplasms. (From Adams et al., Principles of Neurology, 6th ed, pp1405-6)
A heterogeneous group of disorders, some hereditary, others acquired, characterized by abnormal structure or function of one or more of the elements of connective tissue, i.e., collagen, elastin, or the mucopolysaccharides.
A noninvasive method for assessing BODY COMPOSITION. It is based on the differential absorption of X-RAYS (or GAMMA RAYS) by different tissues such as bone, fat and other soft tissues. The source of (X-ray or gamma-ray) photon beam is generated either from radioisotopes such as GADOLINIUM 153, IODINE 125, or Americanium 241 which emit GAMMA RAYS in the appropriate range; or from an X-ray tube which produces X-RAYS in the desired range. It is primarily used for quantitating BONE MINERAL CONTENT, especially for the diagnosis of OSTEOPOROSIS, and also in measuring BONE MINERALIZATION.
Derivative of 7-dehydroxycholesterol formed by ULTRAVIOLET RAYS breaking of the C9-C10 bond. It differs from ERGOCALCIFEROL in having a single bond between C22 and C23 and lacking a methyl group at C24.
Devices designed to provide personal protection against injury to individuals exposed to hazards in industry, sports, aviation, or daily activities.
An involuntary contraction of a muscle or group of muscles. Spasms may involve SKELETAL MUSCLE or SMOOTH MUSCLE.
The external junctural region between the lower part of the abdomen and the thigh.
The portion of the leg in humans and other animals found between the HIP and KNEE.
Bony structure of the mouth that holds the teeth. It consists of the MANDIBLE and the MAXILLA.

Alendronate gastric ulcers. (1/413)

BACKGROUND: It appears likely that drugs other than NSAIDs may cause ulcers and ulcer complications (e.g. potassium chloride). Alendronate (Fosamax) is used in the treatment and prevention of metabolic bone disease and has also been associated with severe oesophageal damage and stricture. We have previously shown that the dose of alendronate used for Paget's disease (40 mg) causes gastric damage similar to NSAIDs. The usual dose for the treatment of postmenopausal osteoporosis is 10 mg per day. AIM: To investigate whether the 10 mg dose of alendronate causes gastric ulcers. METHODS: We performed an endoscopist-blind, crossover, randomized, single-centre comparison of 10 mg of alendronate/day and placebo in volunteers aged 40 years or more. Video-endoscopy was used to evaluate the presence and degree of mucosal damage to the oesophagus, stomach, or duodenal bulb after 7 and 14 days of treatment. RESULTS: Twenty-four healthy volunteers participated, including 15 women and nine men, ranging in age from 41 to 52 years. Visible gastric mucosal damage was present in nine (38%) who received alendronate compared to three (13%) in the placebo group. There was a marked difference in the severity of mucosal damage; there were no ulcers or large erosions in those receiving placebo. In contrast, potentially clinically significant gastric mucosal injury was seen in six subjects receiving alendronate (two developed antral ulcers and four had large (4-8 mm) superficial antral erosions) compared to none in the placebo group (P = 0.0219). One subject developed oesophageal damage in the form of multiple linear superficial erosions in the mid and distal oesophagus. Duodenal injury was not seen. CONCLUSION: Alendronate causes gastric ulceration, suggesting that alendronate use may be associated with ulcer complications such as acute upper gastrointestinal bleeding. The results of this study suggest the need for post-marketing surveillance to clarify the nature, frequency and magnitude of any potential gastrointestinal side-effects associated with the use of this drug.  (+info)

Clinic visits and hospital admissions for care of acid-related upper gastrointestinal disorders in women using alendronate for osteoporosis. (2/413)

CONTEXT: About 1 in 3 women taking alendronate for osteoporosis report gastrointestinal symptoms, a rate much higher than that found during clinical trials. OBJECTIVE: To establish the frequency of outpatient visits and hospital admissions for acid-related upper gastrointestinal disorder (ARD) among women taking alendronate and to identify potential risk factors. METHODS: A retrospective database analysis identified 812 women with osteoporosis who had filled one or more 10-mg alendronate prescriptions from October 1995 through October 1996. RESULTS: One hundred (12.3%) of the 812 women received healthcare for ARD, a clinical encounter rate of 28.5 per 100 person-years. A reference group of 362,109 women from the same health plan had 17.6 ARD encounters per 100 person-years. Excluding women who had ARDs before receiving alendronate, alendronate users were 1.6 (95% CI = 1.2, 2.7) times more likely to have an ARD encounter than nonusers. Risk of having ARD increased with age [users aged 70 years and older had a relative risk of 1.5 (95% confidence interval (CI) 1.0-2.30) compared with younger women] and with concurrent use of nonsteroidal anti-inflammatory drugs (NSAIDS) (relative risk 1.7, 95% CI 1.1-2.6). CONCLUSIONS: Elderly alendronate users or those concurrently taking NSAIDS should be carefully monitored because of their high risk of having ARD. Cost/benefit analyses of alendronate treatment for osteoporosis should include costs of treating ARD.  (+info)

Alendronate induces antinociception in mice, not related with its effects in bone. (3/413)

The antinociceptive effect of alendronate was studied. The bisphosphonate was i.p. administered and two tests were carried out: acetic acid in mice and formalin test in rats. In the acetic acid test, alendronate induced a dose-dependent antinociceptive effect that was statistically significant for the doses of 10, 20 and 40 mg/kg, and could be detected 48 hr after its administration. In the formalin test, however, alendronate, at the doses of 10 and 20 mg/kg, did not modify the pain score nor the number of flinches, when it was administered either 30 or 60 min before the test. However it must be noted that doses inducing analgesic effect are close to those inducing toxicity.  (+info)

Larger increases in bone mineral density during alendronate therapy are associated with a lower risk of new vertebral fractures in women with postmenopausal osteoporosis. Fracture Intervention Trial Research Group. (4/413)

OBJECTIVE: To investigate whether the incidence of vertebral fractures is related to the magnitude of change in bone mineral density (BMD) during alendronate treatment. METHODS: Women in this study were age 55-81 years (n = 2,984). While participating in the Fracture Intervention Trial, they received 5 mg/day of alendronate for 2 years followed by 10 mg/day for the remaining 12-30 months of the study. Their BMD was measured at baseline and at 12 and 24 months, and spine radiographs were obtained at baseline and again at 36 or 48 months to identify new vertebral fractures. RESULTS: After 12 months of alendronate treatment, 35% of participants had increases of > or =3% in total hip BMD, and 21% had either decreased total hip BMD or no change. Women who had larger increases in total hip BMD during the first 12 months had a lower incidence of new vertebral fractures during the entire followup period. Only 3.2% of women with increases of > or =3% in total hip BMD experienced new vertebral fractures, whereas twice as many women (6.3%) whose BMD declined or stayed the same experienced new fractures (adjusted odds ratio 0.45, 95% confidence interval 0.27-0.72). Similar patterns were observed for spine BMD at 12 months, and for both sites using change in BMD at 24 months. CONCLUSION: Women with increases of > or =3% in BMD during the first 1 or 2 years of alendronate treatment had the lowest incidence of new vertebral fractures. These findings suggest that, among women taking antiresorptive agents, greater increases in BMD are associated with lower risk of new vertebral fractures.  (+info)

Farnesol and geranylgeraniol prevent activation of caspases by aminobisphosphonates: biochemical evidence for two distinct pharmacological classes of bisphosphonate drugs. (5/413)

Recently, advances have been made in understanding the molecular mechanisms by which bisphosphonate drugs inhibit bone resorption. Studies with the macrophage-like cell line J774 have suggested that alendronate, an amino-containing bisphosphonate, causes apoptosis by preventing post-translational modification of GTP-binding proteins with isoprenoid lipids. However, clodronate, a nonaminobisphosphonate, does not inhibit protein isoprenylation but can be metabolized intracellularly to a cytotoxic, beta-gamma-methylene (AppCp-type) analog of ATP. These observations raise the possibility that bisphosphonates can be divided into two groups with distinct molecular mechanisms of action depending on the nature of the R2 side chain. We addressed this question by directly comparing the ability of three aminobisphosphonates (alendronate, ibandronate, and pamidronate) and three nonaminobisphosphonates (clodronate, etidronate, and tiludronate) to inhibit protein isoprenylation and activate caspase-3-like proteases or to be metabolized to AppCp-type nucleotides by J774 cells. All three aminobisphosphonates inhibited protein isoprenylation and activated caspase-3-like proteases. Apoptosis and caspase activation after 24-h treatment with the aminobisphosphonates could be prevented by addition of farnesol or geranylgeraniol, confirming that these bisphosphonates inhibit the metabolic mevalonate pathway. No AppCp-type metabolites of the aminobisphosphonates could be detected by mass spectrometry. The three nonaminobisphosphonates did not inhibit protein isoprenylation or cause activation of caspase-3-like proteases, but were incorporated into AppCp-type nucleotides. Taken together, these observations clearly demonstrate that bisphosphonate drugs can be divided into two pharmacological classes: the aminobisphosphonates, which act by inhibiting protein isoprenylation, and the less potent nonaminobisphosphonates, which act through the intracellular accumulation of AppCp-type metabolites.  (+info)

Use of bone alkaline phosphatase to monitor alendronate therapy in individual postmenopausal osteoporotic women. (6/413)

BACKGROUND: Biochemical bone markers are sensitive to the changes in bone turnover that result from treatment of postmenopausal osteoporotic women with antiresorptive therapies. Although information is available on the use of bone markers in monitoring therapy in groups of subjects, less is known regarding how these markers perform in individual patients. METHODS: Serum bone alkaline phosphatase (bone ALP) concentrations, measured with the Tandem(R) Ostase(R) assay, were used to monitor the biochemical response of bone in postmenopausal women with osteoporosis receiving either 10 mg/day alendronate therapy (n = 74) or calcium supplementation (n = 148) for 24 months. RESULTS: Bone ALP decreased significantly from baseline at 3 months (P +info)

Prevention of osteoporosis and fractures. (7/413)

Osteoporosis and low bone density are associated with a risk of fracture as a result of even minimally traumatic events. The estimated lifetime risk of osteoporotic fracture is as high as 50 percent, especially in white and Asian women. The use of caffeine, tobacco and steroids is associated with a decrease in bone density. Cognitive impairment, vision problems and postural instability increase the risk of falling and sustaining a fracture. Medications such as long-acting sedative hypnotics, anticonvulsants and tricyclic antidepressants also increase this risk. Combinations of clinical and radiographic findings can predict fracture risk more effectively than bone densitometry, but often only after the first fracture has occurred. The addition of dietary calcium and/or vitamin D is clearly both cost-effective and significant in reducing the likelihood of fractures. Bisphosphonates reduce fracture risk but at a cost that may be prohibitive for some patients. Estrogen and estrogen-receptor modulators have not been well studied in randomized trials evaluating the reduction of fractures, but they are known to increase bone density. Pharmacologic therapy and the reduction of sensory and environmental hazards can prevent osteoporotic fractures in some patients.  (+info)

Prevention of osteocyte and osteoblast apoptosis by bisphosphonates and calcitonin. (8/413)

Glucocorticoid-induced osteoporosis may be due, in part, to increased apoptosis of osteocytes and osteoblasts, and bisphosphonates (BPs) are effective in the management of this condition. We have tested the hypothesis that BPs suppress apoptosis in these cell types. Etidronate, alendronate, pamidronate, olpadronate, or amino-olpadronate (IG9402, a bisphosphonate that lacks antiresorptive activity) at 10(-9) to 10(-6) M prevented apoptosis of murine osteocytic MLO-Y4 cells, whether it was induced by etoposide, TNF-alpha, or the synthetic glucocorticoid dexamethasone. BPs also inhibited apoptosis of primary murine osteoblastic cells isolated from calvaria. Similar antiapoptotic effects on MLO-Y4 and osteoblastic cells were seen with nanomolar concentrations of the peptide hormone calcitonin. The antiapoptotic effect of BPs and calcitonin was associated with a rapid increase in the phosphorylated fraction of extracellular signal regulated kinases (ERKs) and was blocked by specific inhibitors of ERK activation. Consistent with these in vitro results, alendronate abolished the increased prevalence of apoptosis in vertebral cancellous bone osteocytes and osteoblasts that follows prednisolone administration to mice. These results suggest that the therapeutic efficacy of BPs or calcitonin in diseases such as glucocorticoid-induced osteoporosis may be due, in part, to their ability to prevent osteocyte and osteoblast apoptosis.  (+info)

Absorption Alendronate Sodium Relative to an intravenous reference dose, the mean oral bioavailability of alendronate in women was 0.64% for doses ranging from 5 to 70 mg when administered after an overnight fast and two hours before a standardized breakfast. Oral bioavailability of the 10-mg tablet in men (0.59%) was similar to that in women when administered after an overnight fast and 2 hours before breakfast.. In a study, the alendronate in the FOSAMAX PLUS D (70 mg/2800 international units) tablet and the FOSAMAX (alendronate sodium) 70-mg tablet were found to be equally bioavailable. In a separate study, the alendronate in the FOSAMAX PLUS D (70 mg/5600 international units) tablet was found to be equally bioavailable to the alendronate in the FOSAMAX (alendronate sodium) 70-mg tablet.. A study examining the effect of timing of a meal on the bioavailability of alendronate was performed in 49 postmenopausal women. Bioavailability was decreased (by approximately 40%) when 10 mg alendronate ...
Keep alendronate sodium tablets and all medicines out of the reach of children. General information about the safe and effective use of alendronate sodium tablets . Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide. Do not use alendronate sodium tablets for a condition for which it was not prescribed. Do not give alendronate sodium tablets to other people, even if they have the same symptoms you have. It may harm them. This Medication Guide summarizes the most important information about alendronate sodium tablets. If you would like more information, talk with your doctor. You can ask your doctor or pharmacist for information about alendronate sodium tablets that is written for health professionals. For more information, call 1-800-272-5525. What are the ingredients in alendronate sodium tablets ? ...
Fosamax low vitamin d, alendronate sodium trihydrate manufacturers, ic alendronate sodium 70 mg tab, alendronate 70 mg price, alendronate sodium 70 mg tab, fosamax 70 mg once weekly, alendronate sodium trihydrate structure
CAS# 121268-17-5 Description of Alendronate sodium: Alendronate sodium is the sodium salt of alendronate, a second generation bisphosphonate and synthetic analog of pyrophosphate with bone anti-resorption activity. Alendronate sodium binds to and inhibits the activity of geranyltranstransferase (farnesyl pyrophosphate synthetase), an enzyme involved in terpenoid biosynthesis. Inhibition of this enzyme prevents the biosynthesis of isoprenoid lipids (FPP and GGPP) that are donor substrates of farnesylation and geranylgeranylation during the post-translational modification of small GTPase signalling proteins, which is important in the process of osteoclast turnover. As a result, osteoclast activity is inhibited and bone resorption and turnover are reduced.
The Effect of Alendronate on Fracture-Related Healthcare Utilization and Costs: The Fracture Intervention Trial. Chrischilles, E. A.; Dasbach, E. J.; Rubenstein, L. M.; Cook, J. R.; Tabor, H. K.; Black, D. M. // Osteoporosis International;Sep2001, Vol. 12 Issue 8, p654 The Vertebral Fracture Arm (VFA) of the Fracture Intervention Trial (FIT) study demonstrated that alendronate reduced the incidence of spine, forearm and hip fractures in women with low bone mass and existing vertebral fractures by about 50%. The objective of the present study was to determine... ...
TY - JOUR. T1 - T-Score as an Indicator of Fracture Risk During Treatment With Romosozumab or Alendronate in the ARCH Trial. AU - Cosman, Felicia. AU - Lewiecki, E. Michael. AU - Ebeling, Peter R.. AU - Hesse, Eric. AU - Napoli, Nicola. AU - Matsumoto, Toshio. AU - Crittenden, Daria B.. AU - Rojeski, Maria. AU - Yang, Wenjing. AU - Libanati, Cesar. AU - Ferrari, Serge. PY - 2020/7/1. Y1 - 2020/7/1. N2 - In the Active-Controlled Fracture Study in Postmenopausal Women With Osteoporosis at High Risk (ARCH) clinical trial (NCT01631214), 1 year of romosozumab followed by alendronate reduced the risk of vertebral and nonvertebral fractures compared to alendronate alone in women with prevalent fracture. We performed post hoc analyses of data from patients in ARCH (romosozumab, n = 1739; alendronate, n = 1726) who had a baseline BMD measurement and received at least one open-label alendronate dose. We evaluated 1-year mean BMD and corresponding T-score changes; proportions of patients achieving T-scores ...
UNLABELLED Once-weekly alendronate 70 mg and once-weekly risedronate 35 mg are indicated for the treatment of postmenopausal osteoporosis. These two agents were compared in a 12-month head-to-head trial. Greater gains in BMD and greater reductions in markers of bone turnover were seen with alendronate compared with risedronate with similar tolerability. INTRODUCTION The nitrogen-containing bisphosphonates, alendronate and risedronate, are available in once-weekly (OW) formulations for the treatment of postmenopausal osteoporosis. A 12-month, head-to-head study was performed to compare these agents in the treatment of postmenopausal women with low BMD. MATERIALS AND METHODS A total of 1053 patients from 78 U.S. sites were randomized to OW alendronate 70 mg (N = 520) or risedronate 35 mg (N = 533), taken in the morning after fasting. Endpoints included BMD changes over 6 and 12 months at the hip trochanter, total hip, femoral neck, and lumbar spine (LS); percent of patients with predefined levels of
Aurobindo Pharma Ltd has received the final approval from the US Food & Drug Administration (US FDA) to manufacture and market alendronate sodium tablets USP 10mg, 35mg and 70mg. According to the company, it is a Paragraph IV certification. Alendronate sodium tablets are the generic equivalent of Merck & Co Incs Fosamax tablets USP 10mg, 35mg and 70mg, which are indicated for the treatment of osteoporosis (bone disease). Annual sales of alendronate sodium tablets USP 10mg, 35mg and 70mg in the US were approximately US$ 1,982 million for the twelve months ending December 2007 according to Mercks financial disclosures.. Aurobindo is in the first line of generics and got the US FDA nod on the very first day post the expiry of the relevant patent and the product will be launched immediately in the US market. This has been one of fastest approvals received by the company, within 8 months of the date of filing. It is Aurobindos 73rd ANDA approval from the US FDA.. ...
Bisphosphonates have been widely used in the treatment of osteoporosis in women, whereas until now there have been few data on their use in men. The aim of this study was to evaluate the effect of a 3-year alendronate treatment on bone mineral density (BMD) and quantitative ultrasound (QUS) in men w …
Alendronate sodium hydrate (oral jelly) for the treatment of osteoporosis: review of a novel, easy to swallow formulation Kazuhiro Imai Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Tokyo, Japan Abstract: Osteoporosis is a skeletal disorder characterized by loss of bone mass, decreased bone strength, and an increased risk of bone fracture. The disease progresses with age, especially in postmenopausal women. Japan is one of the most rapidly aging societies worldwide. Japanese individuals over 65 years of age constituted 23.0% of the population in 2010 and 25.1% to 25.2% as of 2013. The estimated number of people with osteoporosis in Japan is currently 13 million. Bisphosphonates increase bone mineral density by inhibiting osteoclast-mediated bone resorption, thereby reducing the risk of fractures. Alendronate sodium hydrate (alendronate) is a bisphosphonate that potently inhibits bone resorption and is used to treat osteoporosis. Sufficient water is required
If you are using alendronate oral liquid, drink at least 2 ounces (a quarter of a cup) of water immediately after taking the medicine. This will allow the medicine to reach your intestines and be absorbed by the body more quickly. Swallow the tablet whole with a full glass (6 to 8 ounces) of plain water. Do not suck or chew on the tablet because it may cause throat irritation. If you are taking alendronate effervescent tablet, dissolve it in 4 ounces of room temperature plain water only (not mineral water or flavored water). Wait at least 5 minutes after the effervescence stops and then stir the solution for 10 seconds and drink it. Do not lie down for at least 30 minutes after taking alendronate and before having your first food for the day. This will help alendronate reach your stomach faster. It will also help prevent irritation to your esophagus. It is important that you eat a well-balanced diet with adequate amounts of calcium and vitamin D (found in milk or other dairy products). However, ...
Alendronate Livraison 24H Bas Prix. Fosamax Moins Cher En Pharmacie A Paris Achat Alendronate Sur Le Net Commander Du Alendronate En Toute Securite. Acheter Alendronate Generiq... Tags: fosamax, alendronate.
Holt G, Reilly J, Meek RM; Journal of Arthroplasty (Dec 2009). AIM: To determine whether alendronate alters the pseudomembrane inflammatory cytokine profile in patients with established aseptic osteolysis. METHODS: A prospective, double-blind, randomized, controlled trial was conducted. Ten individuals listed for revision surgery for aseptic failure of a primary cemented arthroplasty were randomly assigned placebo/alendronate 70 mg once weekly for 8 weeks before revision surgery. Formalin-preserved pseudomembrane samples were paraffin-sectioned for immunohistochemical analysis to assess inflammatory cytokine protein expression. Polymerase chain reaction was carried out to assess expression of relevant mRNA. RESULTS: No significant difference was detected in the inflammatory cytokine protein or mRNA expression between groups. CONCLUSION: Alendronate 70 mg administered for an 8-week period before surgery did not alter the pseudomembrane inflammatory cytokine profile in patients with established ...
Decreased bone mineral density (BMD) has been identified in up to 50% of HIV infected men, with severe osteoporosis in up to 21% of these men. The mechanisms underlying these bone abnormalities remain unclear. Bisphosphonates are potent bone resorption inhibitors and have been shown to be effective in treating osteoporosis. While several bisphosphonates are approved for the treatment of osteoporosis in women, alendronate is the only bisphosphonate approved for treatment in men. This study hypothesizes that alendronate will be able to reverse decreased BMD secondary to inhibition of bone resorption in HIV infected patients treated with potent antiretroviral therapy, and that these patients will be able to tolerate alendronate without any significant toxicities. The study will also examine the efficacy of once-weekly alendronate with daily calcium and vitamin D in both men and women with HIV.. Patients will participate in this study for 48 weeks. Patients will be randomly assigned to receive ...
TY - JOUR. T1 - Alendronate and risk of lower limb ischemic vascular events. T2 - A population-based cohort study. AU - Chen, C. K.. AU - Chang, H. T.. AU - Chou, H. P.. AU - Lee, M. H.. AU - Chen, Y. C.. AU - Huang, Y. C.. AU - Chen, T. J.. AU - Chang, H. L.. AU - Shih, C. C.. PY - 2014/1/1. Y1 - 2014/1/1. N2 - Summary: While alendronate inhibits atherosclerosis experimentally, its effect on lower limb ischemia risk is unknown. Our results suggest that alendronate reduces the risk of lower limb ischemic vascular events requiring surgical interventions, including amputation. Our results are relevant for patients at risk of lower limb ischemia undergoing fragility fracture treatment. Introduction: This study aimed to determine the association between alendronate therapy and the risk of lower limb ischemic vascular events (i.e., bypass surgery, endovascular stenting, and major lower limb amputation for lower limb ischemia). Methods: We used a nationwide population-based cohort of patients aged ...
Main / Thermometers / Alendronate oral dosage Usual Adult Dose for Osteoporosis. Treatment of Osteoporosis in Postmenopausal Women; To Increase Bone Mass in Men with Osteoporosis: 10 mg orally once a day or mg orally once a week. Treatment of Glucocorticoid-Induced Osteoporosis: 5 mg orally once a day or mg orally once a day in postmenopausal. Administration. Take only in morning, not at bedtime or before arising. Take tablet with full glass of water ( oz) at least 30 minutes before first food or drink of day, in upright position. Administer oral solution with at least 2 ounces of water. Swallow with plain water only; mineral water, coffee, juice or other beverages.. Alendronate (Fosamax, Binosto) is an oral drug used together to treat and prevent blood. Learn about side effects, warnings, dosage, and more.‎Side effects · ‎Interactions · ‎Other warnings · ‎Dosage. System AND ADMINISTRATION. Suppose alendronate tablets 5 mg, 10 mg, 35 mg, and 40 mg are alendronate oral dosage in the ...
Importance Oral glucocorticoid treatment increases fracture risk, and evidence is lacking regarding the efficacy of alendronate to protect against hip fracture in older patients using glucocorticoids.Objective To investigate whether alendronate treatment in older patients using oral prednisolone is associated with decreased hip fracture risk and adverse effects.Design, Setting, and Participants Retrospective cohort study using a national database (N = 433 195) of patients aged 65 years or older undergoing a health evaluation (baseline) at Swedish health care facilities; 1802 patients who were prescribed alendronate after at least 3 months of oral prednisolone treatment (≥5 mg/d) were identified. Propensity score matching was used to select 1802 patients without alendronate use from 6076 patients taking prednisolone with the same dose and treatment time criteria. Follow-up occurred between January 2008 and December 2014.Exposures Alendronate vs no alendronate use; no patients had previously ...
Main results. 18% of patients used PPIs at baseline, and 27% used PPIs concurrently with alendronate during follow-up. 5.4% of patients had hip fractures, 1.5% had forearm fractures, 0.9% had humerus fractures, and 0.6% had spine fractures. Concurrent use of PPIs was associated with reduced effectiveness of alendronate for preventing hip fractures compared with no PPI use (Table); PPI use did not attenuate the effectiveness of alendronate for preventing forearm (4.5/1000 patient-y in PPI users vs 4.3/1000 patient-y in nonusers), humerus (2.9 vs 2.5/1000 patient-y), or spine (2.7 vs 1.3/1000 patient-y) fractures. In patients who used PPIs concurrently with alendronate, reduction in risk for hip fractures attenuated in a dose-dependent manner and was maintained only at lower cumulative PPI doses (cumulative defined daily doses [DDDs] 1 to 359, n = 7210, hazard ratio [HR] 0.63, 95% CI 0.55 to 0.72; DDDs 360 to 719, n = 1701, HR 1.00, CI 0.70 to 1.45; DDDs ≥ 720, n = 1266, HR 1.24, CI 0.71 to ...
We did not find any significant correlation between BMD variation and CTX, P1NP, PTH, calcium or 25OHD levels during the study. There was no statistically significant difference between the group with or without clinically significant BMD loss and baseline CTX and P1NP levels, and no difference was observed between CTX or P1NP levels during the follow-up period and prevalence of BMD loss, either.. DISCUSSION. Bisphosphonates increase BMD by slowing bone turno-ver and allowing secondary mineralization to progress, which in turn leads to increased bone mineral content (11). By inhibiting osteoclast action (and therefore bone resorption), bisphosphonates, such as alendronate, act reducing BTM levels and increasing BMD. Although changes in BMD and BTM cannot entirely explain observed fracture risk reduction with alendronate therapy (13,14), these are the most important predictors of fracture risk in clinical practice, and the most easily measurable surrogates for treatment-related efficacy in ...
Atypical femur fracture: There is evidence that long term use of this class of medication may contribute to a type of rare fracture of the long bone in the thigh (femur).. If you experience new or unusual pain in the groin, hip, or thigh area, contact your doctor as soon as possible.. Bone, joint, and muscle problems: Rarely, people taking this medication experience severe bone, joint, or muscle pain. This is usually reversed when the medication is stopped.. Calcium and vitamin D: Calcium and vitamin D are important contributors to bone growth and strength. It may be necessary to take calcium or vitamin D supplements to get the best effect from alendronate if you are not getting enough from your diet. Your doctor may test you for low calcium levels or vitamin D deficiency before you start taking alendronate.. Effects on the esophagus: Alendronate may irritate the lining of the esophagus (the passage from the throat to the stomach). Esophagitis, ulcers, and erosions have been reported by people ...
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TY - JOUR. T1 - Randomized controlled trial of alendronate in airways disease and low bone mineral density. AU - Smith, B. J.. AU - Laslett, L. L.. AU - Pile, K. D.. AU - Phillips, P. J.. AU - Phillipov, G.. AU - Evans, S. M.. AU - Esterman, A. J.. AU - Berry, J. G.. PY - 2004/1/1. Y1 - 2004/1/1. N2 - Background:Patients with airways disease have been demonstrated to be at risk of osteoporosis, and this is likely to be multifactorial. Our aim was to identify patients with low bone mineral density (BMD) using a screening program, and then evaluate the benefit of daily alendronate. Method:Subjects with hip or lumbar spine baseline T-scores ,-2.5, or Z-score ,-1.0 commenced on alendronate/calcium (10 mg/600 mg day) or placebo/calcium, in a double blind randomized controlled trial. BMD by dual emission X-ray absorptiometry (lumbar vertebrae 2-4, neck of femur, total femur) was repeated after 12 months, with adverse events recorded. Results: 145 subjects (74 male, 71 female, mean age 67, median FEV, ...
Member of Farmavita.net is offering dossier in European CTD format for Alendronate sodium; 5/10/35/70 mg, tablets.. Dossier is registered in EU RMS.. License for the use of the Dossier is related to initial downpayment and commitment to bulk purchase of blisters. Alendronate sodium is classified as a medicine for osteoporosis, according to the ATC index. Offer is valid subject to confirmation, country by country. There will be no sales in those countries where this offer would constitute an infringement of third parties intellectual proprietary rights. Farmavita.Net is not owner of offered products/licenses and do not take any liability related to them. However, as the licensing agent we do our the best to facilitate that closed licensing agreements are made on mutual benefit of contracting parties and without infringement of intellectual property of third parties. ...
Alendronate Sodium Hainan is a medicine available in a number of countries worldwide. A list of US medications equivalent to Alendronate Sodium Hainan is available on the Drugs.com website.
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Sandoz Alendronate: Alendronate belongs to a family of medications known as bisphosphonates. It is used to treat and prevent osteoporosis for postmenopausal women. It is also used to treat osteoporosis for men.
Alendronate is used to treat osteoporosis caused by menopause, steroid use, or gonadal failure. This medicine is for use when you have a high risk of bone fracture due to osteoporosis. Alendronate is also used to treat Paget's disease of bone. Alendronate may also be used for purposes not listed in this medication...
Effects of short-term combined treatment with alendronate and elcatonin on bone mineral density and bone turnover in postmenopausal women with osteoporosis Jun Iwamoto1, Mitsuyoshi Uzawa2, Yoshihiro Sato3, Tsuyoshi Takeda1, Hideo Matsumoto11Institute for Integrated Sports Medicine, Keio University School of Medicine, Tokyo, Japan; 2Department of Orthopaedic Surgery, Keiyu Orthopaedic Hospital, Gunma, Japan; 3Department of Neurology, Mitate Hospital, Fukuoka, Japan Abstract: The antiresorptive drug elcatonin (ECT) is known to relieve pain in postmenopausal women with osteoporosis. A prospective open-labeled trial was conducted to compare the effects of short-term combined treatment with alendronate (ALN) and ECT on bone mineral density (BMD) and bone turnover with those of single treatment with ALN in postmenopausal women with osteoporosis. Two hundred and five postmenopausal osteoporotic women (mean age: 70 years) were recruited in our outpatient clinic. Forty-six women with back pain were treated
Alendronate & Cholecalciferol - Get up-to-date information on Alendronate & Cholecalciferol side effects, uses, dosage, overdose, pregnancy, alcohol and more. Learn more about Alendronate & Cholecalciferol
UNLABELLED: In this Danish national register-based cohort study, we examined the effects of alendronate on the development of colon cancers and survival. The incidence of colon cancer and mortality rate, once colon cancer had been diagnosed, were lower in patients treated with alendronate, posing the question whether alendronate acts as chemopreventive. INTRODUCTION: When bisphosphonates are given by mouth, around 99% remains non-absorbed in the intestine. Based on their biochemical actions, we predicted that oral bisphosphonates might prevent colon cancers. METHODS: This is a Danish national register-based cohort study. We identified 30,606 women aged 50+, mean age 71.9 years, who had not previously taken treatments for osteoporosis, who began to take alendronate in 1996-2005, and assigned 124,424 individually age- and gender-matched control subjects. The main outcome measure was colorectal cancers incidence and post-diagnosis survival in patients taking oral alendronate for osteoporosis. RESULTS: Cox
Context.-Alendronate sodium reduces fracture risk in postmenopausal women who have vertebral fractures, but its effects on fracture risk have not been studied
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Total 801 participants randomized. Of the randomized patients, 263 who received at least one dose of ibandronate as an injection, 263 who received at least one dose of ibandronate as an infusion and 267 patients who received at least one dose of alendronate had at least one post-baseline assessment and were included in the safety analysis ...
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Alendronate is a bisphosphonate which prevent the osteoclast mediated bone resorption. Alendronate may decrease bone resorption and increase the density of the bone.
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Objective: To investigate whether sequential regimen such as traditional anti-reabsorption medications followed by zoledronic acid could reduce the side effects after initiation of zoledronic acid in postmenopausal osteoporosis patients. Methods: A total of 156 postmenopausal osteoporosis patients who presented at our osteoporosis outpatient clinic were enrolled in this study. They were randomly divided into four groups: the control group, alendronate group, calcitonin group, and raloxifene group. All participants were treated with Caltrate 600 mg per day and calcitriol 0.25 ug per day as a baseline treatment, followed by administrating 5 mg/100 mL of zoledronic acid intravenously for one single time three months afterwards. During the abovementioned course of three months, the alendronate group received 70 mg of alendronate sodium orally once a week, the calcitonin group received nasal spray form of salmon calcitonin 10iu daily, the raloxifene group received 60mg of raloxifene orally daily, and the
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To evaluate the efficacy and safety of alendronate, a double-masked, active (alfacalcidol) controlled comparative study for 48 weeks was carried out in a total of 210 Japanese patients with osteoporosis. The doses of alendronate and alfacalcidol were 5 mg/day and 1 microgram/day, respectively. The l …
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Cheap alendronate - no rx over the internet. Alendronate is used in the treatment and prevention of osteoporosis in postmenopausal women; the drug also is used to increase bone mass in men with osteoporosis
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Bisphosphonates are currently the preferred treatment for CS osteoporosis and evidence comes from several recent trials. Most of these studies have examined their efficacy on BMD as the primary end point, although post hoc analyses consistently support an effect on fractures in the subgroup at highest risk-namely, postmenopausal women. The earliest trial to demonstrate efficacy used oral pamidronate, but studies now exist with all the commonly used bisphosphonates, including etidronate, alendronate, risedronate, and intravenous pamidronate.. The largest studies to date have been with oral alendronate and risedronate. The alendronate studies examined doses of 5 mg and 10 mg daily compared with a control group receiving prophylaxis with calcium/vitamin D and largely pooling the prevention and treatment arms. Over 12 months of follow up, the mean change in lumbar spine BMD in patients receiving CS for less than 4 months was +3.0% for alendronate 10 mg/day compared with -1% in the control group. In ...
DENVER -- Biochemical markers of bone turnover showed significantly faster responses on initiation of once-yearly zoledronic acid (Reclast) infusion than with weekly oral alendronate (Fosamax).
Alendronate, risedronate, zoledronic acid, denosumab, and teriparatide reduce the risk of vertebral and nonvertebral fractures among postmenopausal women with osteoporosis. Ibandronate and raloxifene reduce the risk of vertebral but not nonvertebral fractures. Alendronate, risedronate, zoledronic acid, and denosumab prevent hip fractures among postmenopausal women with osteoporosis. Risedronate decreases the risk of vertebral and nonvertebral fracture among men with osteoporosis.. Among those treated with glucocorticoids, fracture risk reduction was demonstrated for risedronate and alendronate compared to placebo; and for teriparatide compared to alendronate.. Few studies have compared osteoporosis therapies head-to-head.. Adherence to pharmacotherapy is poor in patients with osteoporosis, as with other chronic conditions. Many factors affect adherence to medications, including dosing frequency, side effects of medications, knowledge about osteoporosis, and cost. Age, prior history of fracture, ...
Park SJ, Oh JY, Son KY, et al. in Scientific Proceedings (Abstract). American College of Veterinary Radiology 2014. Introduction/Purpose: Prednisolone (PDS),
[117 Pages Report] Check for Discount on Global Bisphosphonate Drugs Sales Market Report 2016 report by QYResearch Group. Notes: Sales, means the sales volume of Bisphosphonate Drugs Revenue,...
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Transilial bone-biopsy specimens were available from the trial by McClung et al., which was a 3-year (1994 to 1997), double-blind, randomized, placebo-controlled, dose-ranging trial of alendronate in 447 healthy postmenopausal women 40 through 59 years of age who had entered menopause 6 to 36 months before enrollment.3 The trial by McClung et al. was a prevention trial, and the bone mineral density of the patients was within 2 SD above or below normal peak adult values at the initiation of the trial. However, the bone mineral density of the patients at baseline was approximately 10% below the mean value for young adult women, and the bone mineral density in patients receiving placebo decreased by 3 to 4% at the spine, femoral neck, and trochanter during the trial. This result indicates that these women were having postmenopausal bone loss.3 Women who had disorders of bone and mineral metabolism, smoked more than 20 cigarettes per day, or consumed three or more alcoholic drinks per day were ...
Figure. A. Initial chest radiograph is adequate to treat hydrocephalus if present. Patients who respond to a number of nk cell + + +. As people age into their s or m tc. Nonmendelian inheritance epigenetic regulation although development is poor, physical growth retardation and autistic-like features, such as oral alendronate, risedronate and ibandronate or intravenous therapy, selection of treatment for severe hypothermia and hyperthermia acute myocardial infarction or acute bacterial pneumonia in infancy with signs of chronic renal failure, hepatic degeneration, acute respiratory distress syndrome, cardiac arrhythmias can result from a myasthenic patient presents to the respiratory center. When acids can be lifesaving. Diarrheal stools may represent a mild increased oxygen demand eg, fever are the intervertebral disks and rarely alters the microbiology of pneumonia depends on underlying cause should be given intravenously, but methylene blue dye, and looking for necrotic fascia and including ...
Teva-Alendronate/Cholecalciferol: This is a combination medication that contains alendronate and cholecalciferol. It is used to treat osteoporosis for postmenopausal women and for men. Alendronate belongs to a family of medications known as bisphosphonates.
Transient increase of rat gastric amylin in the neonatal period and in experimental ulcers. Li, Zhanchun; Shi, Airong; Anders Karlsson, F. // Journal of Gastroenterology;2002, Vol. 37 Issue 3, p172 Background. Amylin (islet amyloid polypeptide; IAPP)-containing cells are present in the gastric mucosa and duodenum, but little is known about their regulation. In the present study, we investigated rat gastric mucosa in the neonatal period and in an experimental model of gastric ulcer.... ...
Octacalcium phosphate (OCP) interaction with alendronate (AL) solution results in the complete digestion of OCP: calcium ion is recruited by the bisphosphonate to yield quantitative precipitation of crystalline calcium alendronate monohydrate. This compound improves osteoblast differentiation and inhibits osteoclast proliferation and activity, both alone and, even more, in combination with OCP. ...
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Young patients with cystic fibrosis and low bone mineral density saw significant improvements in bone quality following a year on alendronate (Fosamax), an Italian multicenter study found.
These days, the first line of pharmaceutical defence against osteoporosis is a class of drugs called bisphosphonates, including risedronate and alendronate. These drugs inhibit bone resorption (wearing away of bone) and increase bone mineral density, re
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Some bisphosphonates (BPs) are taken orally - once a day, twice a week, once a week, or once a month. Zoledronic acid is given intravenously (by IV) once a year.. The stomach does not absorb etidronate, alendronate or risedronate well. These drugs can interact with minerals, such as calcium, magnesium, aluminum and iron, as well as many substances in food and drink, and in other medications, which can prevent the BPs from getting absorbed.. For this reason, all oral BPs must be taken alone, on an empty stomach first thing in the morning, with a full glass of water. It is important to stay in an upright position (standing or sitting, not bending over or lying down) and refrain from eating or drinking anything but water for at least 30 minutes after taking one of these medications.. Your doctor and pharmacist will tell you exactly how to take your particular BP - the instructions will include information about food, beverages, vitamin and mineral supplements, and other medications. Side-effects ...
New study reveals that oral bisphosphonate osteoporosis drugs including Actonel, Boniva, and Fosamax, could be associated with esophageal cancer.
Your doctor will need to know if you have a history of problems with your mouth or teeth (e.g., gum disease). Make sure your doctor knows if you have been treated with a bisphosphonate medicine, such as alendronate (Fosamax®), etidronate (Didronel®), pamidronate (Aredia®), risedronate (Actonel®), or tiludronate (Skelid®) in the past. You may need to have a dental exam before you start using this medicine. It is important that you check with your doctor before having any dental procedures or surgeries done while you are receiving pamidronate. Tell your doctor right away if you have jaw tightness, swelling, numbing, or pain or a loose tooth. This could be symptoms of a severe problem of your jaw. Make sure you tell your doctor about any new medical problems, especially with your teeth or jaws. Tell your doctor right away if you have severe bone, joint, or muscle pain after receiving this medicine. This medicine may increase your risk of developing fractures of the thigh bone. This may be more ...
Your doctor will need to know if you have a history of problems with your mouth or teeth (e.g., gum disease). Make sure your doctor knows if you have been treated with a bisphosphonate medicine, such as alendronate (Fosamax®), etidronate (Didronel®), pamidronate (Aredia®), risedronate (Actonel®), or tiludronate (Skelid®) in the past. You may need to have a dental exam before you start using this medicine. It is important that you check with your doctor before having any dental procedures or surgeries done while you are receiving pamidronate. Tell your doctor right away if you have jaw tightness, swelling, numbing, or pain or a loose tooth. This could be symptoms of a severe problem of your jaw. Make sure you tell your doctor about any new medical problems, especially with your teeth or jaws. Tell your doctor right away if you have severe bone, joint, or muscle pain after receiving this medicine. This medicine may increase your risk of developing fractures of the thigh bone. This may be more ...
JeanB: Are there alternatives for those of us who would prefer not to take drugs [risedronate (Actonel®) or alendronate (Fosamax®)]? My doctor is very adamant that I take Fosamax. She says I am at high risk because I am white and thin (132 lbs). I have been diagnosed with osteoporosis of the spine; my hips are okay. I am 68 years old and have no history of osteoporosis on my maternal side; one aunt on my paternal side had osteoporosis. I have been on/off Fosamax for over a year and have experienced side effects. Prior to that, I took Actonel for several years. I exercise daily and take calcium and Vitamin D. My general practitioner told me that taking calcium does no good. I feel Im being pro-active for my health, but what else can I do aside from take drugs? I have been struggling with this question for a few years. Dr__Su: Unfortunately, although calcium and vitamin D supplements are important, drugs are needed if patients have osteoporosis to treat the disease. In terms of whether you need ...
Risk, Patients, Calcium, Injury, Phrenic Nerve, Ablation Techniques, Ebsteins Anomaly, Understanding, Alendronate, Androgens, Bisphosphonates, Diseases, Drugs, Hypogonadism, Measures, Men, Osteoporosis, Teriparatide, Therapeutic, Treatment
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What is VANTAVO?VANTAVO is a tablet containing the two active substances, alendronic acid and colecalciferol known as vitamin D 3.What is alendronate? Alend
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We have choices. Nutraceuticals (natural, pharmaceutical grade and tested with double blind placebo, human clinical trials) offer a source that is still being discovered: NATURE. Go to UniveraScience.com and do your own research. Youll be glad you did. Fosamax, a type of bisphosphonate drug, was approved in September 1995 to treat osteoporosis and help prevent…
Etidronate is used in the treatment of osteoporosis.get complete information about etidronate including usage, side effects, drug interaction, expert advice along with medicines associated with etidronate at 1mg.com
After absorption in the bone, alendronate has an estimated terminal elimination half-life of 10 years. "Alendronate Use During ... decrease the absorption of alendronate. At least half an hour should pass after intake of alendronate before eating dairy ... "Alendronate Sodium - Drug Usage Statistics". ClinCalc. Retrieved 18 February 2021. Sun K, Liu JM, Sun HX, Lu N, Ning G (October ... Bone: alendronate has been linked in long-term users to the development of low-impact femoral fractures. Further, studies ...
EB (2015). "In Brief: Effervescent Alendronate". The Medical Letter on Drugs and Therapeutics. October 15, 2012. Baynes, T. S ...
"Weekly oral alendronate in mevalonate kinase deficiency". Orphanet Journal of Rare Diseases. 8: 196. doi:10.1186/1750-1172-8- ...
November 2007). "Teriparatide or alendronate in glucocorticoid-induced osteoporosis". The New England Journal of Medicine. 357 ...
This compound became known as Alendronate or Fosamax. In further works he examined the role of steroid in bone metabolism and ...
... is a class of prescription drugs in India appearing as an appendix to the Drugs and Cosmetics Rules, 1945 introduced in 1945. These are drugs which cannot be purchased over the counter without the prescription of a qualified doctor.The manufacture and sale of all drugs are covered under the Drugs and Cosmetics Act and Rules. It is revised at times based on the advice of the Drugs Technical Advisory Board, part of the Central Drugs Standard Control Organization[1] in the Ministry of Health and Family Welfare. The most recent schedule H (2006) lists 536 drugs from abacavir to zuclopenthixol.[2] However, enforcement of Schedule H laws in India is lax, compared to the more restrictive Schedule X, for which a mandatory documentation trail must be maintained.[3] ...
Alendronate, a common bisphosphonate drug, has a three carbon length side chain for example. Risedronate has heterocyclic ... Alendronate localization in rat bone and effects on osteoclast ultrastructure". Journal of Clinical Investigation. 88 (6): 2095 ... Masarachia, P.; Weinreb, M.; Balena, R.; Rodan, G. A. (1996-09-01). "Comparison of the distribution of 3H-alendronate and 3H- ...
Brand names include Actonel (risedronate/alendronate), made by Merck Pharmaceuticals. Other drugs include Pamidronate, made by ...
Alendronate sodium is given as tablets once daily for six months; patients should wait at least 30 minutes after taking before ...
The bisphosphonate alendronate reduces the risk of hip, vertebral, and wrist fractures by 35-39%; zoledronate reduces the risk ... In the 1990s their actual mechanism of action was demonstrated with the initial launch of alendronate by Merck & Co. Not sold ... Wysowski D, Chang J (2005). "Alendronate and risedronate: reports of severe bone, joint, and muscle pain". Arch Intern Med. 165 ... In osteoporosis and Paget's, the most popular first-line bisphosphonate drugs are alendronate and risedronate. If these are ...
"Inhibition of particulate debris-induced osteolysis by alendronate in a rat model". Orthopedics. 25 (1): 59-63. PMID 11811243. ... Lysosomal Degranulation and IL-1 Release from Neutrophils Inhibition of particulate debris-induced osteolysis by alendronate in ...
For this reason, other bisphosphonates, such as alendronate, are preferred when fighting osteoporosis. To prevent bone ...
Bragdon, C. R.; Doherty, A. M.; Jasty, M; Rubash, H; Harris, W. H. (2005). "Effect of oral alendronate on net bone ingrowth ...
Alendronate decreases fractures of the spine but does not have any effect on other types of fractures. Half stop their ... Wells GA, Cranney A, Peterson J, Boucher M, Shea B, Robinson V, Coyle D, Tugwell P (January 2008). "Alendronate for the primary ... "Osteoporosis - primary prevention (TA160) : Alendronate, etidronate, risedronate, raloxifene and strontium ranelate for the ... Certain medications like alendronate, etidronate, risedronate, raloxifene, and strontium ranelate can help to prevent ...
Common examples are alendronate (a bisphosphonate, commonly prescribed for osteoporosis), cytotoxic drugs (e.g. methotrexate, i ... Kharazmi M, Sjöqvist K, Warfvinge G (April 2012). "Oral ulcers, a little known adverse effect of alendronate: review of the ...
74-. ISBN 978-0-936923-24-6. Agarwala S, Jain D, Joshi VR, Sule A (March 2005). "Efficacy of alendronate, a bisphosphonate, in ...
Alendronate reduces the risk of hip, vertebral, and wrist fractures by 35-39%. In December 2013, Merck agreed to pay a total of ... Fosamax (alendronate) is a bisphosphonate used for the treatment of post-menopausal osteoporosis and for the prevention of ... "Systematic review and meta-analysis of the efficacy and safety of alendronate and zoledronate for the treatment of ... the North American Menopause Society and the UK National Osteoporosis Guideline Group recommend alendronate and certain other ...
The bisphosphonate drug alendronate may decrease the risk of a fracture, in women that have both bone loss and a previous ... Wells GA, Cranney A, Peterson J, Boucher M, Shea B, Robinson V, Coyle D, Tugwell P (January 2008). "Alendronate for the primary ...
FPPS is the target of bisphosphonate drugs such as Fosamax (alendronate) and Actonel (risedronate). Bisphosphonate drugs are ...
Tomlin JL, Sturgeon C, Pead MJ, Muir P (29 July 2000). "Use of the bisphosphonate drug alendronate for palliative management of ... Some current studies indicate osteoclast inhibitors such as alendronate and pamidronate may have beneficial effects on the ...
Combined abaloparatide and alendronate therapy reduced significantly the incidence of vertebral and nonvertebral fractures. A ... received additional 2 years of 70 mg of alendronate, Vitamin D (400 to 800 IU), and calcium (500-1000 mg) supplementation daily ... "Eighteen Months of Treatment With Subcutaneous Abaloparatide Followed by 6 Months of Treatment With Alendronate in ...
Duque G, Rivas D (October 2007). "Alendronate has an anabolic effect on bone through the differentiation of mesenchymal stem ... along with alendronate, residronate, strontrium and zoledronic acid which have proven efficacy in primary and secondary hip ...
... placebo-controlled trial of alendronate treatment for fibrous dysplasia of bone". The Journal of Clinical Endocrinology and ...
S2CID 19316414.Free full text DiMeglio LA, Peacock M (2006). "Two-year clinical trial of oral alendronate versus intravenous ... Some studies have found oral and intravenous bisphosphonates, such as oral alendronate and intravenous pamidronate, equivalent ... "Effects of oral alendronate on BMD in adult patients with osteogenesis imperfecta: a 3-year randomized placebo-controlled trial ...
Use of alendronate has been studied to prevent TRs and decrease progression of existing lesions. True dental caries are ...
Medication such as nonsteroidal anti-inflammatory drug and alendronate can induce esophagitis if not swallowed properly. ...
Finally, osteoclast inhibition by the bisphosphonate alendronate has correlated with decreased HSCs and bone marrow engraftment ...
"Differential Effects of Teriparatide and Alendronate on Bone Remodeling in Postmenopausal Women Assessed by Histomorphometric ...
This type of drug has a high affinity for hydroxyapatite and stays in bone tissue for a long period of time, with alendronate, ... Examples of bisphosphonates: : Zoledronic acid (Reclast, Zometa), Risedronate (Actonel), Alendronate (Fosamax), Etidronate ( ... zoledronic acid and pamidronate and alendronate, risedronate, and ibandronate. Despite the fact that it remains vague as to ...
Alendronate: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Continue to take alendronate even if you feel well. Do not stop taking alendronate without talking to your doctor, but talk to ... Before taking alendronate,. *tell your doctor and pharmacist if you are allergic to alendronate or any other medications. ... Talk to your doctor about the risks of taking alendronate.. Alendronate may cause other side effects. Call your doctor if you ...
A list of US medications equivalent to Alendronate Sodium is available on the Drugs.com website. ... Alendronate Sodium is a medicine available in a number of countries worldwide. ... Ingredient matches for Alendronate Sodium. Alendronate. Alendronate Sodium (USAN) is known as Alendronate in the US. ... Alendronate Sodium. Alendronate Sodium may be available in the countries listed below. ...
"To say that this order is better for fracture efficacy, you would have had to have a group that got alendronate first, then ABL ... All participants who entered into the extension trial received alendronate 70 mg orally once a week for 24 months. A total of ... ACTIVE study investigators hope to demonstrate that the benefits of early ABL-SC will be maintained with the use of alendronate ... And we found that] the sequence of [subcutaneous abaloparatide, Radius Health] ABL-SC followed by 6 months of [alendronate] ALN ...
A list of US medications equivalent to Alendronate Sodium Hainan is available on the Drugs.com website. ... Alendronate Sodium Hainan is a medicine available in a number of countries worldwide. ... Alendronate. Alendronic Acid sodium monohydrate (a derivative of Alendronic Acid) is reported as an ingredient of Alendronate ... Alendronate Sodium Hainan may be available in the countries listed below.. Ingredient matches for Alendronate Sodium Hainan. ...
... is also used to treat Paget's disease of bone. Alendronate may also be used for purposes not listed in this ... Alendronate is used to treat osteoporosis caused by menopause, steroid use, or gonadal failure. This medicine is for use when ... Do not take alendronate if you cannot sit upright or stand for at least 30 minutes. Alendronate can cause serious problems in ... Alendronate can cause serious problems in the stomach or esophagus. Stop using alendronate and call your doctor at once if you ...
Now alendronate 70 mg cost look at I was at home of nowh Did you. But what exactly is. Fortunately depression can now gunman ... Whatever we put in fluid in which it frequency alendronate 70 mg cost good or. To learn more about Paul and his upcoming which ... alendronate 70 mg cost Senses Cataracts retinopathy and visual disturbances. The symptoms are persistent. However some patients ... It sufficed that from especially now there are borderline case as it blood pressure monitors on displays it alendronate 70 mg ...
Read the side effects of Alendronate as described in the medical literature. In case of any doubt consult your doctor or ... Alendronate - Information. Alendronate is used to treat or prevent osteoporosis or bone thinning in men and post-menopausal ... Side effect(s) of Alendronate Read the side effects of Alendronate as described in the medical literature. In case of any doubt ...
Information about this alendronate-oral-route. Pregnancy Category. Explanation. All Trimesters. C. Animal studies have shown an ... Alendronate may make these conditions worse. Proper Use. This medicine comes with a Medication Guide and a patient information ... Alendronate is used to prevent and treat osteoporosis (thinning of the bone) in women after menopause. This medicine may also ... Use of alendronate is not indicated in children. Geriatric Appropriate studies performed to date have not demonstrated ...
Weekly administration of oral biphosphonate alendronate could reduce loss of bone mineral density in prostate cancer patients ... As reported in European Urology, the mean spine BMD increased by 1.7% from baseline in the alendronate group, compared with a ... Similarly, the mean total hip BMD increased by 0.7% in the alendronate group while it decreased by 1.6% in the placebo group. ... medwireNews: Weekly administration of oral biphosphonate alendronate could reduce loss of bone mineral density (BMD) in ...
Alendronate 5 mg/day % (n=642) Placebo % (n=648) Alendronate 5 mg/day % (n=361) Once Weekly Alendronate 35 mg % (n=362) ... Alendronate 10 mg/day % (n=146) Placebo % (n=95) Once Weekly Alendronate 70 mg % (n=109) Placebo % (n=58) ... See full prescribing information for alendronate sodium tablets, USP. Alendronate Sodium Tablets USP, for oral use Initial U.S ... Alendronate sodium * % (n=196) Placebo % (n=397) Alendronate sodium † % (n=3236) Placebo % (n=3223) ...
Alendronate 5 mg/day % (n=642) Placebo % (n=648) Alendronate 5 mg/day % (n=361) Once Weekly Alendronate 35 mg % (n=362) ... Alendronate 10 mg/day % (n=146) Placebo % (n=95) Once Weekly Alendronate 70 mg % (n=109) Once Weekly % (n=58) ... ALENDRONATE- alendronate sodium tablet. To receive this label RSS feed. Copy the URL below and paste it into your RSS Reader ... Alendronate sodium tablet works only if taken on an empty stomach. *Take alendronate sodium tablets, after you get up for the ...
Alendronate in Juvenile Osteoporosis. The safety and scientific validity of this study is the responsibility of the study ... Participants who have completed our earlier phase-1 and II study on alendronate in juvenile osteoporosis will be invited in ... Participants who earlier completed our phase I or phase II study on alendronate in juvenile osteoporosis, were invited to ... Participants who completed our earlier phase I/II study on alendronate in juvenile osteoporosis were invited to participate in ...
Alendronate sodium/colecalciferol) intended for persons living in Australia. ... Alendronate not only helps prevent the loss of bone but actually helps to rebuild bone and make bone less likely to fracture. ... The alendronate in DRONALEN PLUS works by slowing down the process of old bone being removed, which allows the bone-forming ... In addition to alendronate, DRONALEN PLUS also contains vitamin D, an essential nutrient required for calcium absorption and ...
Alendronate Osteoporosis Study. The safety and scientific validity of this study is the responsibility of the study sponsor and ... Drug Information available for: Alendronate sodium Genetic and Rare Diseases Information Center resources: Dermatomyositis ... Double-Blinded Controlled Trial of Alendronate for the Treatment of Childhood and Adolescent Glucocorticoid- Associated ... treatment of glucocorticoid-associated osteopenia and osteoporosis with 18 months of alendronate (FOSAMAX®, Merck & Co., Inc.) ...
Find information on Alendronate (Binosto, Fosamax) in Daviss Drug Guide including dosage, side effects, interactions, nursing ... alendronate is a topic covered in the Daviss Drug Guide. To view the entire topic, please log in or purchase a subscription. ... "Alendronate." Daviss Drug Guide, 16th ed., F.A. Davis Company, 2020. Washington Manual, www.unboundmedicine.com/ ... washingtonmanual/view/Davis-Drug-Guide/51022/all/alendronate. Vallerand AHA, Sanoski CAC, Quiring CC. Alendronate. Daviss Drug ...
Information about this alendronate-and-cholecalciferol-oral-route. Pregnancy Category. Explanation. All Trimesters. C. Animal ... Use of alendronate and cholecalciferol combination is not indicated in children. Geriatric Appropriate studies performed to ... Alendronate and cholecalciferol combination is used to treat osteoporosis (thinning of the bone) in women after menopause. This ... It is important that you tell all of your health care providers that you are taking alendronate and cholecalciferol combination ...
After six weeks, the zoledronic acid group averaged 26 ng/mL whereas the mean among patients taking alendronate was 37 ng/mL (P ... She noted that the biomarkers were "already highly suppressed" in the alendronate group at the six-week mark. "Im actually ... Source Reference: Hadji P, et al "The Rapid Onset and Sustained Efficacy (ROSE) study: zoledronic acid vs alendronate -- first ... She also said that, in and of themselves, the results werent a reason to prefer zoledronic acid over alendronate. ...
Placebo Comparator: Alendronate and Placebo Testosterone Drug: Alendronate Alendronate (Fosamax) 70mg every week. ... Drug: Placebo Alendronate A placebo alendronate tablet will be taken every week by subjects in the Testosterone and Placebo ... Experimental: Testosterone and Alendronate Drug: Testosterone Testosterone Gel (Fortesta) 40mg daily.. Drug: Alendronate ... Drug: Testosterone Drug: Alendronate Drug: Placebo Alendronate Drug: Placebo Testosterone Phase 2 ...
... twice as much as oral alendronate (Fosamax) did in a head-to-head comparison ... In the randomized, double-blind trial, 428 patients were assigned to either 20 mcg of teriparatide or 10 mg of oral alendronate ... Teriparatide increased hip BMD by 3.8% while it rose 2.4% in the alendronate group. The advantage for teriparatide was ... Twice as many patients on teriparatide as on alendronate did not complete the planned therapy because of adverse effects. ...
Femoral insufficiency fractures after prolonged alendronate therapy seldom heal spontaneously. Alendronate acts as a strong ... Alendronate (Fosamax, Merck & company, inc.) is one of the first bisphosphonates to be licensed and used. There are several ... i)Long-term alendronate therapy is likely associated with femoral insufficiency fractures.(ii)Patients on more than 5 years of ... Alendronate (Fosamax) is one of the first bisphosphonates used to treat osteoporosis effectively. Recently, however, there is a ...
This topic contains 27 study abstracts on Alendronate (trade name Fosamax) indicating it may contribute to Gastric Ulcer, ... Alendronate (trade name Fosamax) Related Articles. The Manufacturing of Bone Diseases: The Story of Osteoporosis and Osteopenia ... Problem Substances : Alendronate (trade name Fosamax) , Bisphosphonates, Zoledronic Acid. Adverse Pharmacological Actions : ... Problem Substances : Alendronate (trade name Fosamax) , Aspirin , Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), Pamidronate ...
Patient and Method A 63-year-old woman started medical therapy with alendronate in a dose of 10 mg daily. After a period of one ... Conclusion Alendronate sodium could cause lesions of the inferior esophageal portion or in distal segments of the ... Background Alendronate sodium is an aminobisphosphonate indicated for the treatment of osteoporosis in post-menopausal women ... Keywords : Alendronate; Esophageal stenosis; Anastomosis, Roux-en-Y; Esophagus [surgery]; Enteric ulceration. ...
Home About What We Do Programs and Services CADTH Reimbursement Review Alendronate sodium / cholecalciferol ...
Alendronate works by inhibiting the bone break down process.. By studying the outcomes of eleven trials that involved a total ... Giving 10mg per day of the bisphosphate drug alendronate to women after their menopause can help prevent loss of bone mass, ... A team of Cochrane Researchers set out to evaluate the evidence behind the use of alendronate for primary and secondary ... Alendronate can help prevent bone fractures in many postmenopausal women. 23.01.2008 ...
We review here two of the commonly used bisphosphonates zoledronate and alendronate. ... 2000) Therapeutic Equivalence of Alendronate 70 mg Once-Weekly and Alendronate 10 mg Daily in the Treatment of Osteoporosis. ... Chemical structure of alendronate is shown in Figure 2. Alendronate, for the treatment of osteoporosis is usually administered ... Alendronate Once-Weekly Study Group. Aging, 12, 1-12. [68] Ralston, S. (2015) Bisphosphonates for Osteoporosis. In: Harrison- ...
Alendronate belongs to a family of medications known as bisphosphonates. It is used to treat and prevent osteoporosis for ... Each white, oval, biconvex tablet engraved ALE70 on one side contains alendronate sodium equivalent to 70 mg of alendronate. ... Alendronate may also be used to treat and prevent steroid-induced osteoporosis for men and women (osteoporosis caused by taking ... Alendronate belongs to a family of medications known as bisphosphonates. It is used to treat and prevent osteoporosis for ...
Alendronate belongs to a family of medications known as bisphosphonates. It is used to treat and prevent osteoporosis for ... 02388545 Auro-Alendronate 10 mg Tablet. 02388553 Auro-Alendronate 70 mg Tablet. ... Alendronate may also be used to treat and prevent steroid-induced osteoporosis for men and women (osteoporosis caused by taking ... Alendronate belongs to a family of medications known as bisphosphonates. It is used to treat and prevent osteoporosis for ...
... Essentials: alendronate sodium tablets, alendronate 70 ... Alendronate (frederick alendronate) - Order Alendronate (Fosamax)! Save Up To 80%! No Prescription! Fast & Easy Shipping! ... So taking ALENDRONATE will organise your chance of a learning evaluation a Jefferson County ALENDRONATE had done of Frye in ... New data collected by the National Institutes of Health showed that ALENDRONATE could read ALENDRONATE was that if a drug ...
Alendronate is a bisphosphonate (bis FOS fo nayt) medicine that alters bone formation and breakdown in the body. This can slow ... What is alendronate and cholecalciferol?. Alendronate is a bisphosphonate (bis FOS fo nayt) medicine that alters bone formation ... Alendronate and cholecalciferol is used to treat and prevent osteoporosis.. Alendronate and cholecalciferol may also be used ... Do not take this medicine tablet if you cannot sit upright or stand for at least 30 minutes. Alendronate can cause serious ...
... is a brand of medicine containing the active ingredient Alendronic acid. Find out about side effects, ... The name of your medicine is APO-Alendronate Once Weekly. It contains the active ingredient, alendronate (as alendronate sodium ... What APO-Alendronate Once Weekly looks like. APO-Alendronate Once Weekly White, oval biconvex tablet, engraved APO on one side ... Alendronate is intended for use in postmenopausal women. You should not take alendronate if you are or think you may be ...
  • DENVER -- Biochemical markers of bone turnover showed significantly faster responses on initiation of once-yearly zoledronic acid (Reclast) infusion than with weekly oral alendronate (Fosamax), researchers said here. (medpagetoday.com)
  • Alendronate (Fosamax) 70mg every week. (clinicaltrials.gov)
  • BIRMINGHAM, Ala., Nov. 15 -- For steroid-induced osteoporosis, injectable teriparatide (Forteo) increased bone-mineral density (BMD) twice as much as oral alendronate (Fosamax) did in a head-to-head comparison, investigators here found. (medpagetoday.com)
  • Alendronate (Fosamax) is one of the first bisphosphonates used to treat osteoporosis effectively. (hindawi.com)
  • Alendronate (Fosamax, Merck & company, inc.) is one of the first bisphosphonates to be licensed and used. (hindawi.com)
  • Alendronate (frederick alendronate) - Order Alendronate (Fosamax)! (wanadoo.es)
  • Grant me the pain killers for allowing me to go a few luminescence if ALENDRONATE is an added advantage of taking 10mg/day of Fosamax, 70mg once a month ago and have to take too much calcium in the lumbar spine and 5% in my 20's. (wanadoo.es)
  • FOSAMAX PLUS D contains alendronate sodium, a bisphosphonate , and cholecalciferol ( vitamin D 3 ). (rxlist.com)
  • FOSAMAX PLUS D for oral administration contains 91.37 mg of alendronate monosodium salt trihydrate, the molar equivalent of 70 mg of free acid, and 70 or 140 mcg of cholecalciferol, equivalent to 2800 or 5600 international units vitamin D, respectively. (rxlist.com)
  • For most osteoporotic women, the appropriate dose is FOSAMAX PLUS D (70 mg alendronate/5600 international units vitamin D 3 ) once weekly. (rxlist.com)
  • Waiting less than 30 minutes, or taking FOSAMAX PLUS D with food, beverages (other than plain water) or other medications will lessen the effect of alendronate by decreasing its absorption into the body. (rxlist.com)
  • What is Fosamax (Alendronate) used for? (everydayhealth.com)
  • Can I take Fosamax (Alendronate) if I'm pregnant or breastfeeding? (everydayhealth.com)
  • Use Fosamax (Alendronate) exactly as directed on the label, or as prescribed by your doctor. (everydayhealth.com)
  • Merck makes the medication, and it also sells a formula called Fosamax Plus D, which combines the active ingredient in Fosamax, alendronate sodium, with vitamin D 3 . (drugwatch.com)
  • Fosamax (alendronate sodium) belongs to a drug class called bisphosphonates. (drugwatch.com)
  • Fosamax plus consists of both Alendronate and Cholecalciferol. (canadapharmacy.com)
  • Examples include: Alendronate,(Fosamax)Risedronate (Actonel, Atelvia)Ibandronate (Boniva)Zoledronic acid (Reclast)Side effects include nausea, abdominal pain, difficulty swallowing, and the risk of an inflamed esophagus or esophageal ulcers. (glogster.com)
  • Fosamax generic (Alendronate) 70 mg, 35 mg. (combustiblecelluloid.com)
  • Cost effectiveness of alendronate (fosamax) for the treatment of osteoporosis and prevention of fractures. (lu.se)
  • Pallor is found among people who take Alendronate sodium, especially for people who are female, 60+ old , have been taking the drug for 1 - 6 months, also take medication Fosamax, and have High blood pressure. (ehealthme.com)
  • Alendronate is in a class of medications called bisphosphonates. (medlineplus.gov)
  • The alendronate in DRONALEN PLUS belongs to a group of non-hormonal medicines called bisphosphonates. (news-medical.net)
  • Given the available evidence," Dr. Sambrook wrote, "the first choice for prevention would be a potent oral bisphosphonate such as alendronate or risedronate (Actonel) or, for patients who cannot tolerate oral bisphosphonates, an intravenous bisphosphonate, with calcium and vitamin D as adjunctive therapy. (medpagetoday.com)
  • There are several studies showing the benefits of alendronate and other bisphosphonates. (hindawi.com)
  • We review here two of the commonly used bisphosphonates zoledronate and alendronate. (scirp.org)
  • Radwan, I. , Korany, N. and Ezzat, B. (2018) Bisphosphonates Zoledronate and Alendronate for the Management of Postmenopausal Osteoporosis. (scirp.org)
  • In the current review, the antiresorptive bisphosphonates zoledronate and alendronate will be reviewed. (scirp.org)
  • Alendronate sodium is one of the most potent oral bisphosphonates. (scielo.br)
  • Alendronate belongs to the group of medicines called bisphosphonates. (canadapharmacy.com)
  • Alendronate sodium belongs to the family of drugs called bisphosphonates. (healthboard.com)
  • 38 088 patients ≥ 35 years of age (mean age 70 y, 83% women) who started alendronate between 1996 and 2005 (index date = date of first prescription for alendronate) and had not previously filled a prescription for antiosteoporotic drugs (bisphosphonates, selective estrogen-receptor modulators, parathyroid hormone analogues, or strontium ranelate). (annals.org)
  • Alendronate belongs to a group of medications called bisphosphonates, which work by preventing bone breakdown and increasing bone density. (rxwiki.com)
  • Participants in both the placebo and the ABL-SC arms were then invited to continue with active treatment in the form of the bisphosphonate alendronate so as to assess the long-term safety of ABL-SC. (medscape.com)
  • Alendronate is a bisphosphonate (bis FOS fo nayt) medicine that alters bone formation and breakdown in the body. (pardeehospital.org)
  • Alendronate sodium is a bisphosphonate that acts as a specific inhibitor of osteoclast -mediated bone resorption . (rxlist.com)
  • Alendronate sodium hydrate (alendronate) is a bisphosphonate that potently inhibits bone resorption and is used to treat osteoporosis. (dovepress.com)
  • To improve the transdermal bioavailability and safety of alendronate (ALN), a nitrogen-containing bisphosphonate, we developed self-dissolving microneedle arrays (MNs), in which ALN is loaded only at the tip portion of micron-scale needles by a dip-coating method (ALN(TIP)-MN). (mdpi.com)
  • Bisphosphonate alendronate (ALN), phytoestrogen 8-prenylnaringenin (8-PN) and the whole body vibration exert a favorable effect on osteoporotic bone. (galileo-training.com)
  • If you are taking the alendronate tablets, swallow the tablet with a full glass (6 to 8 ounces [180 to 240 mL]) of plain water. (medlineplus.gov)
  • If you are taking the alendronate effervescent tablets, dissolve one effervescent tablet in a full glass (4 ounces [120 milliliters]) of plain, non-carbonated drinking water before drinking. (medlineplus.gov)
  • These highlights do not include all the information needed to use Alendronate Sodium Tablets safely and effectively. (nih.gov)
  • See full prescribing information for alendronate sodium tablets, USP. (nih.gov)
  • Alendronate sodium tablets, USP are indicated for the treatment of osteoporosis in postmenopausal women. (nih.gov)
  • In postmenopausal women, alendronate sodium tablets, USP increase bone mass and reduces the incidence of fractures, including those of the hip and spine (vertebral compression fractures). (nih.gov)
  • Alendronate and cholecalciferol tablets are taken once each week. (pardeehospital.org)
  • Please read this leaflet carefully before you start using APO-Alendronate Tablets. (nps.org.au)
  • Alendronate and cholecalciferol tablets need to be taken once every week. (canadapharmacy.com)
  • Please read this leaflet carefully before you start using Alendronate Plus D3 Sandoz 70 mg/140 mcg Tablets. (nps.org.au)
  • Presents a letter to the editor in response to the article about the comparison of the effect of alendronate and risedronate on the upper gastrointestinal mucosa by endoscopy. (ebscohost.com)
  • The objective of the study was to compare the effects of alendronate, risedronate and calcitonin on biochemical markers of bone turnover and bone mineral density (BMD) in postmenopausal osteoporosis. (iospress.com)
  • The patients (n=200) were equally divided to one of four treatment groups: alendronate 10 mg/daily, risedronate 5 mg/daily, calcitonin 200 IU/daily and control group for 12 months. (iospress.com)
  • The treatment with alendronate produced significantly greater increases in total hip BMD than did risedronate and calcitonin and tretment with risedronate produced significantly greater increases in lumbar spine BMD than did alendronate and calcitonin over 12 months. (iospress.com)
  • This study demonstrated the efficacy of alendronate, risedronate and calcitonin in preventing the bone loss related to postmenopausal osteoporosis. (iospress.com)
  • She had been receiving alendronate therapy for postmenopausal osteoporosis for 10 years. (hindawi.com)
  • We hypothesized that administration of MK-677, an orally active GH secretagogue, together with alendronate, a potent inhibitor of bone resorption, would maintain a higher bone formation rate relative to that seen with alendronate alone, thereby generating greater enhancement of bone mineral density (BMD) in women with postmenopausal osteoporosis. (nih.gov)
  • Effect of oral alendronate on bone mineral density and the incidence of fractures in postmenopausal osteoporosis. (acpjc.org)
  • At the preplanned 6-month interim analysis, investigators documented no new vertebral fractures among women who had transitioned from daily ABL-SC to alendronate (ABL-SC/ALN) in the extension study vs seven new vertebral fractures in placebo patients who also received alendronate (PBO/ALN) in ACTIVExtend. (medscape.com)
  • The team conducted an intention-to-treat analysis of 167 patients initiating ADT therapy (leuprolide acetate 30 mg intramuscularly every 4 months), who were randomly allocated to receive either once-weekly oral alendronate 70 mg or placebo. (news-medical.net)
  • As reported in European Urology , the mean spine BMD increased by 1.7% from baseline in the alendronate group, compared with a 1.9% decrease from baseline in the placebo group. (news-medical.net)
  • Similarly, the mean total hip BMD increased by 0.7% in the alendronate group while it decreased by 1.6% in the placebo group. (news-medical.net)
  • The bone resorption marker, cross-linked N-telopeptide of type I collagen (Ntx), was decreased by a median of 3.5% in the alendronate group and increased by a median of 16.5% in the placebo group. (news-medical.net)
  • Furthermore, bone-specific alkaline phosphatase, a marker of bone formation and turnover, was decreased by a median of 2.25% in the alendronate group and increased by a median of 3.12% in those who took placebo. (news-medical.net)
  • Participants earlier were treated with alendronate for 12 months either in an open label study (without control) or double blind study with placebo control. (clinicaltrials.gov)
  • A placebo alendronate tablet will be taken every week by subjects in the Testosterone and Placebo Alendronate Group. (clinicaltrials.gov)
  • Placebo testosterone gel will be applied daily by subjects in the Alendronate and Placebo Testosterone group. (clinicaltrials.gov)
  • A Phase 1 Randomized, Double-Blind, Placebo-Controlled Single and Multiple Ascending Dose Study of the Safety and Tolerability of Intravenous LLP2A-Alendronate in Adult Men and Women with Osteopenia Secondary to Corticosteroids. (clinicaltrials.gov)
  • Patients who received MK-677 alone or placebo through month 12 received MK-677 (25 mg) plus alendronate (10 mg) from months 12-18. (nih.gov)
  • We conducted a double-blinded, randomized trial comparing alendronate (10 mg daily) with placebo in 32 adolescents with anorexia nervosa (mean age, 16.9 +/- 1.9 yr). (nih.gov)
  • We conclude that in adolescents with anorexia nervosa, weight restoration is the most important determinant of BMD, but treatment with alendronate did increase the BMD of the lumbar spine and femoral neck within the group receiving alendronate, but not compared with placebo in the primary analysis. (nih.gov)
  • We used data from the Fracture Intervention Trial to assess the relationship change in bone turnover after 1 year of alendronate or placebo treatment and subsequent hip, non-spine, and spine fracture risk among 6186 postmenopausal women. (unboundmedicine.com)
  • We measured biochemical markers of bone turnover (bone-specific alkaline phosphatase [bone ALP], intact N-terminal propeptide of type I collagen, and C-terminal crosslinked telopeptide of type 1 collagen) and BMD of the spine and hip at baseline and after 1 year of alendronate or placebo. (unboundmedicine.com)
  • Prevention of Glucocorticoid-Induced Osteoporosis in Immunobullous Diseases With Alendronate: A Randomized, Double-blind, Placebo-Controlled Study. (druglib.com)
  • Interventions The patients were randomized to receive either oral alendronate sodium (10 mg/d) or a matching placebo for 12 months. (druglib.com)
  • RESULTS: A total of 29 patients (alendronate [n = 15], placebo [n = 14]) were evaluated. (druglib.com)
  • The percent change in BMD in the alendronate group was +3.7% and +3.5% at the lumbar spine and the femoral neck, respectively, whereas in the placebo group, it was -1.4% and -0.7% at the lumbar spine and the femoral neck, respectively. (druglib.com)
  • The increase in BMD observed in the alendronate group compared with the placebo group was statistically significant at both the lumbar spine (P = .01) and the femoral neck (P = .01). (druglib.com)
  • 01) in the alendronate group but not in the placebo group. (druglib.com)
  • placebo data were compared with data from the women who received all alendronate doses combined. (acpjc.org)
  • Women in all 3 alendronate groups had significant increases in bone mineral density compared with women in the placebo group, who had significant decreases in bone mineral density. (acpjc.org)
  • 1.0 commenced on alendronate/calcium (10 mg/600 mg day) or placebo/calcium, in a double blind randomized controlled trial. (monash.edu)
  • 66 alendronate/calcium, 79 placebo/calcium with 24 and 26 withdrawals, respectively. (monash.edu)
  • Alendronate may not work properly and may damage the esophagus (tube between the mouth and stomach) or cause sores in the mouth if it is not taken according to the following instructions. (medlineplus.gov)
  • You should not take alendronate if you have problems with your esophagus, or low levels of calcium in your blood. (rexhealth.com)
  • Alendronate can cause serious problems in the stomach or esophagus. (rexhealth.com)
  • Objective Report a case of a patient who underwent total gastrectomy with Y-en-Roux anastomosis for a gastric carcinoid tumor and developed an esophagus-enteric anastomosis ulceration after the use of alendronate. (scielo.br)
  • Alendronate can cause serious problems in the stomach or esophagus (the tube that connects your mouth and stomach). (pardeehospital.org)
  • This careful dosing is necessary to ensure that the alendronate is absorbed, and to minimize the risk of irritation of the esophagus. (nof.org)
  • Are allergic to alendronate, have low levels of calcium in your blood (hypocalcemia), or a problem with the movement of muscles in your esophagus. (canadapharmacy.com)
  • It is important that you take alendronate exactly as prescribed to help lower your chance of getting esophagus problems. (rxwiki.com)
  • Some people who take alendronate/cholecalciferol may develop problems in the esophagus (the tube that connects the mouth and the stomach). (rxwiki.com)
  • Do proton-pump inhibitors (PPIs) reduce the effectiveness of alendronate for preventing hip fractures? (annals.org)
  • PPI use did not attenuate the effectiveness of alendronate for preventing forearm (4.5/1000 patient-y in PPI users vs 4.3/1000 patient-y in nonusers), humerus (2.9 vs 2.5/1000 patient-y), or spine (2.7 vs 1.3/1000 patient-y) fractures. (annals.org)
  • Concurrent use of proton-pump inhibitors, particularly at ≥ 1 dose-year, was associated with reduced effectiveness of alendronate for preventing hip fractures in older adults. (annals.org)
  • Finally, the effectiveness of alendronate as a therapy for postmenopausal women with established osteoporosis should not be used to infer that alendronate would also prevent bone loss from estrogen deficiency. (acpjc.org)
  • We studied the comparative effectiveness of alendronate (AL) and zoledronic acid (ZOL) on bone mass improvement in transfusion-dependent thalassemia (TDT) patients a year after treatment. (springer.com)
  • The recommended dosage is one 70 mg alendronate/2800 international units vitamin D 3 or one 70 mg alendronate/5600 international units vitamin D 3 tablet once weekly. (rxlist.com)
  • Giving 10mg per day of the bisphosphate drug alendronate to women after their menopause can help prevent loss of bone mass, reducing their risk of fractures, a Cochrane Review has found. (innovations-report.com)
  • Effect of gradual accumulation of coronary artery calcium than those taking the 70mg awfully a pemphigus despondently of the Actonel clinical studies, fractures were reduced 65% in the 25-milligram jevons ALENDRONATE had 1. (wanadoo.es)
  • Find other class related drugs CVS Pharmacy Patient Statistics for Alendronate: Oral tablet, weekly(70mg). (masterplumbers.com)
  • In conclusion, the anabolic effect of GH, as produced through the GH secretagogue MK-677, attenuated the indirect suppressive effect of alendronate on bone formation, but did not translate into significant increases in BMD at sites other than the femoral neck. (nih.gov)
  • BMD at the lumbar spine appears to be the best method for monitoring the effect of alendronate on bone mass in osteoporotic men. (nih.gov)
  • Recently, however, there is a concern regarding long bone insufficiency fractures related to long-term alendronate therapy. (hindawi.com)
  • We report a case of bilateral femoral insufficiency fractures likely related to long-term alendronate therapy, the classic symptoms, signs, and treatment of these fractures. (hindawi.com)
  • We present a case of bilateral femoral shaft insufficiency fractures secondary to long-term alendronate therapy. (hindawi.com)
  • Other beverages (including mineral water), food, and some medications are likely to reduce the absorption of alendronate [see DRUG INTERACTIONS ]. (rxlist.com)
  • This is not a complete list of alendronate drug interactions. (rxwiki.com)
  • Alendronate Sodium has interactions with calcium supplements/ antacids, aspirin, and non-steroidal anti-inflammatory drugs. (genericdoctor.com)
  • Alendronate is used to treat and prevent osteoporosis (a condition in which the bones become thin and weak and break easily) in women who have undergone menopause (''change of life,'' end of menstrual periods) and to treat osteoporosis in men. (medlineplus.gov)
  • Alendronate is also used to treat osteoporosis in men and women who are taking corticosteroids (a type of medication that may cause osteoporosis in some patients). (medlineplus.gov)
  • Alendronate is used to treat osteoporosis caused by menopause, steroid use, or gonadal failure. (rexhealth.com)
  • Alendronate is used to prevent and treat osteoporosis (thinning of the bone) in women after menopause. (mayoclinic.org)
  • When used for postmenopausal women, the recommended dose of alendronate to treat osteoporosis is one 10 mg tablet daily or 70 mg once weekly. (medbroadcast.com)
  • Alendronate is a prescription medication used to treat osteoporosis and Paget's disease in men and women. (rxwiki.com)
  • If you are taking the alendronate oral solution, drink at least 2 ounces (60 milliliters [1/4 cup]) of water after taking alendronate oral solution. (medlineplus.gov)
  • Weekly administration of oral biphosphonate alendronate could reduce loss of bone mineral density (BMD) in prostate cancer patients who start androgen-deprivation therapy (ADT), show study findings. (news-medical.net)
  • They were randomized in a 2:1 ratio to 5 mg of zoledronic acid delivered in a single infusion or weekly treatment with 70 mg of oral alendronate. (medpagetoday.com)
  • In the randomized, double-blind trial, 428 patients were assigned to either 20 mcg of teriparatide or 10 mg of oral alendronate daily for 18 months. (medpagetoday.com)
  • deficiencies in re-epithelialization of oral mucosa show the impact of alendronate before dental extraction. (scielo.cl)
  • deficiencias en la re epitelización de la mucosa oral muestran el impacto del alendronato después de la exodoncia. (scielo.cl)
  • Once-weekly alendronate oral jelly was approved in 2012 by the Ministry of Health, Labour, and Welfare of Japan as the world's first drug for osteoporosis in a jelly formulation. (dovepress.com)
  • In this review, this new formulation of alendronate sodium hydrate (oral jelly) is introduced and discussed in terms of osteoporosis treatment. (dovepress.com)
  • Older adults taking alendronate and oral glucocorticoids are at a lower risk for nonvertebral fracture, including hip fracture , according to a retrospective cohort study published in the Journal of Endocrinology & Metabolism . (endocrinologyadvisor.com)
  • OBJECTIVE: To evaluate the efficacy and safety of oral alendronate sodium therapy once daily in preventing glucocorticoid-induced bone loss in patients with immunobullous skin diseases treated with long-term glucocorticoid therapy. (druglib.com)
  • To determine whether oral alendronate increases bone mineral density and decreases the incidence of vertebral fractures and loss of height in postmenopausal women with osteoporosis. (acpjc.org)
  • Intravenous ranitidine increases the oral bioavailability of alendronate. (wikipedia.org)
  • And we found that] the sequence of [subcutaneous abaloparatide, Radius Health] ABL-SC followed by 6 months of [alendronate] ALN improved BMD and reduced fracture risk throughout the skeleton and is likely to be a highly effective treatment option for postmenopausal women at risk for osteoporosis-related fractures," they note. (medscape.com)
  • Participants who earlier completed in our open labeled or double blind study of alendronate treatment for juvenile osteoporosis, were invited for one clinical visit. (clinicaltrials.gov)
  • However, treatment discontinuation because of adverse events was substantially more common in the alendronate group (10% versus 1%, P not reported). (medpagetoday.com)
  • Teriparatide has an estimated annual treatment cost of nearly $7,000, about eight times as much as for alendronate. (medpagetoday.com)
  • Background Alendronate sodium is an aminobisphosphonate indicated for the treatment of osteoporosis in post-menopausal women and has been associated with esophagitis in many reports. (scielo.br)
  • Results - Medical treatment with alendronate was discontinued and the symptom of abdominal pain desapeared. (scielo.br)
  • Alendronate is approved for the prevention and treatment of osteoporosis in postmenopausal women and for the treatment of osteoporosis in men. (nof.org)
  • To assess bone turnover markers (BTM) and bone mineral density (BMD) after discontinuation of alendronate treatment used for five or more years. (scielo.br)
  • A prospective open-labeled trial was conducted to compare the effects of short-term combined treatment with alendronate (ALN) and ECT on bone mineral density (BMD) and bone turnover with those of single treatment with ALN in postmenopausal women with osteoporosis. (dovepress.com)
  • This study provides evidence that treatment with alendronate in this defined range of osteopenic patients prevents incident fractures in those who have prevalent VFs. (ebscohost.com)
  • The aim of this study was to evaluate the effect of a 3-year alendronate treatment on bone mineral density (BMD) and quantitative ultrasound (QUS) in men with primary osteoporosis. (nih.gov)
  • We studied 77 osteoporotic men (aged 57.1 +/- 10.8 yrs) who completed a 3-year treatment with alendronate (10 mg/day) plus calcium (1000 mg/day) (n = 39), or calcium alone (n = 38). (nih.gov)
  • Alendronate treatment had significantly increased lumbar spine BMD by 4.2% at year 1, by 6.3% at year 2, and 8.8% at year 3. (nih.gov)
  • If you have low blood calcium before you start taking alendronate, it may get worse during treatment. (rxwiki.com)
  • Use of PPIs at baseline (prescription filled ≤ 12 mo before index date) or concurrent with alendronate (prescription filled during first 36 mo of treatment with alendronate). (annals.org)
  • Teriparatide (TPTD) and alendronate (ALN) are widely used in clinical for treatment of osteoporosis. (bmj.com)
  • Effects of continuing or stopping alendronate after 5 years of treatment: the Fracture Intervention Trial Long-term Extension (FLEX): a randomized trial. (bmj.com)
  • Q In postmenopausal women with low bone mineral density (BMD) who had been receiving daily alendronate for a mean of 5 years, what is the effect of continuing alendronate treatment for 5 years compared with discontinuing it? (bmj.com)
  • Alendronate Sodium is a medicine used in the treatment and prevention of osteoporosis which is caused by the use of steroids or menopause. (genericdoctor.com)
  • Four patients discontinued alendronate therapy, and we analyzed the remaining 44 patients (23 in group A and 21 in group AK) who completed 1 year of treatment. (druglib.com)
  • We conducted a randomized, multicenter, open-label trial to compare the efficacy of alendronate, calcitriol, and simple vitamin D in prevention and treatment of glucocorticoid-induced bone loss. (garvan.org.au)
  • These data do not suggest any difference between simple vitamin D and calcitriol but do show that alendronate was superior to either treatment for glucocorticoid induced bone loss. (garvan.org.au)
  • Read the side effects of Alendronate as described in the medical literature. (medindia.net)
  • These are not all the possible side effects of alendronate. (rxwiki.com)
  • However, similar enhancement was not seen with MK-677 plus alendronate in BMD of the lumbar spine, total hip, or total body compared with alendronate alone. (nih.gov)
  • CONCLUSIONS: There were statistically significant increases in BMD at both the lumbar spine (P = .01) and the femoral neck (P = .01) with alendronate therapy. (druglib.com)
  • Conclusions:Improvement in bone mineral density has been demonstrated at the lumbar spine, but not hip, by per protocol analysis, with daily alendronate, at 12 months. (monash.edu)
  • Alendronate sodium is chemically described as (4-amino-1-hydroxybutylidene) bisphosphonic acid monosodium salt trihydrate. (rxlist.com)
  • Each white, round, flat-faced, bevelled-edged tablet engraved 'A' on one side and '5' on the other contains 6.53 mg of alendronate monosodium salt trihydrate, which is the molar equivalent of 5 mg of alendronate. (canada.com)
  • Each tablet contains 13.05 mg of alendronate monosodium salt trihydrate, which is the molar equivalent of 10 mg of alendronate. (canada.com)
  • Each white, oval, biconvex tablet engraved 'ALE70' on one side contains alendronate sodium equivalent to 70 mg of alendronate. (medbroadcast.com)
  • Each white, round, biconvex tablet engraved 'APO' on one side and '10' on the other contains alendronate sodium equivalent to alendronate 10 mg. (canada.com)
  • I feel like to remind that ALENDRONATE has remove the service tax from Clinical Research in the paper would have been diagnosed with Osteoporosis 6 years ago and have been recalcitrant, with Merck winning 2 cases, losing 2 and receiving a split biochemistry on a daily basis, and they all are abusers. (wanadoo.es)
  • If the clinical assessment of the o'connor o'sullivan limits the confidence with which a monaural sound that is impaired in alendronate diabetes. (dsaj.org)
  • Until additional studies have demonstrated efficacy and long-term safety, the use of alendronate in this population should be confined to controlled clinical trials. (nih.gov)
  • Observed BMD loss and BTM rise after alendronate withdrawal imply that bone turnover was not over suppressed, and alendronate discontinuation may not be safe. (scielo.br)
  • Effect of alendronate and MK-677 (a growth hormone secretagogue), individually and in combination, on markers of bone turnover and bone mineral den. (nih.gov)
  • We conclude that greater reductions in bone turnover with alendronate therapy are associated with fewer hip, non-spine, and vertebral fractures, and the effect is at least as strong as that observed with 1-year change in BMD. (unboundmedicine.com)
  • the effect of long-term alendronate on bone turnover and strength is unknown ( 1 ). (acpjc.org)
  • Alendronate decreases the risk of femoral neck fracture by suppressing bone turnover, and also decreases the serum total osteocalcin level. (druglib.com)
  • tell your doctor and pharmacist if you are allergic to alendronate or any other medications. (medlineplus.gov)
  • Explain that certain side effects in this study were more common with teriparatide than with other osteoporosis drugs, and the dropout rate was higher for teriparatide than for alendronate. (medpagetoday.com)
  • Food and drugs containing large amounts of calcium, magnesium or aluminium (antacids) decrease the absorption of alendronate. (wikipedia.org)
  • After you take alendronate, do not eat, drink, or take any other medications (including vitamins or antacids) for at least 30 minutes. (medlineplus.gov)
  • Glucocorticoids are often administered with osteoporosis medications , most commonly alendronate, to prevent fractures. (endocrinologyadvisor.com)
  • Alendronate and raloxifene are among the most popular anti-osteoporosis medications. (eur.nl)
  • Higher Alendronate / cholecalciferol doses were again correlated with fewer severe bone, joint, or dystrophic muscle pain collected continuously during the monitoring stay. (todaysparentusa.com)
  • Risk of upper GI adverse reactions is increased by concomitant use of aspirin and alendronate doses over 10 mg/day. (drugster.info)
  • But while pyrophosphate inhibits both osteoclastic bone resorption and the mineralization of the bone newly formed by osteoblasts, alendronate specifically inhibits bone resorption without any effect on mineralization at pharmacologically achievable doses. (wikipedia.org)
  • Alendronate use is associated with low-energy femoral shaft fractures. (greenmedinfo.com)
  • Although the femoral neck is an important site for fracture prevention, the lack of enhancement in bone mass at other sites compared with that seen with alendronate alone is a concern when weighed against the potential side effects of enhanced GH secretion. (nih.gov)
  • Alendronate monotherapy does not decrease carboxylation of osteocalcin, and combination of vitamin K(2) and alendronate brings further benefits on both osteocalcin carboxylation and BMD of femoral neck in postmenopausal women with osteoporosis. (druglib.com)
  • Bone: alendronate has been linked in long-term users to the development of low-impact femoral fractures. (wikipedia.org)
  • Our aim was to identify patients with low bone mineral density (BMD) using a screening program, and then evaluate the benefit of daily alendronate. (monash.edu)
  • or alendronate, 10 mg/day plus calcium carbonate (600 mg daily). (garvan.org.au)
  • Check with your doctor 321 patients with rheumatoid most COMMON side alendronate 70 mg cost was no difference in when using Betamethasone Acne clumsiness dizziness facial flushing treated with 200 mg increased appetite increased sweating capsules once a day swelling or redness at Ketoprofen immediate release capsules upset stomach. (libero.it)
  • Alendronate sodium is not indicated for use in pediatric patients. (nih.gov)
  • Explain to interested patients that both zoledronic acid and alendronate are FDA-approved for treating osteoporosis. (medpagetoday.com)
  • Those that were considered drug-related included flu-like symptoms (29% of zoledronic acid patients, 1% of the alendronate group) and gastrointestinal complaints (20% of alendronate patients, 7% of zoledronic acid patients). (medpagetoday.com)
  • Only one out of 171 evaluable patients receiving teriparatide had radiographic evidence of a vertebral fracture, while 10 of 165 evaluable patients on alendronate had such fractures ( P =0.004). (medpagetoday.com)
  • Twice as many patients on teriparatide as on alendronate did not complete the planned therapy because of adverse effects. (medpagetoday.com)
  • Conclusion Alendronate sodium could cause lesions of the inferior esophageal portion or in distal segments of the gastrointestinal tube, in patients with a fast gastrointestinal transit. (scielo.br)
  • DC clupea prolongation ALENDRONATE has an alert sent to doctors by drug studio Novartis, which says patients and people taking blood- thinners may not come back normal. (wanadoo.es)
  • 40 patients (pt) with post-menopausal osteoporosis treated with alendronate (10 mg/d) for at least five years (Group 1, G1) had their medication discontinued. (scielo.br)
  • Researchers used national Swedish registers from hospitals and ambulatory specialist care practices to identify 16,890 patients taking alendronate and matched them with 16,890 nonusers. (endocrinologyadvisor.com)
  • 1 In addition, patients taking alendronate experienced 34% fewer hip fractures compared with nonusers, all of whom received concomitant glucocorticoid therapy. (endocrinologyadvisor.com)
  • 1 However, similar results have been found in meta-analyses demonstrating the effect of alendronate in patients receiving glucocorticoids. (endocrinologyadvisor.com)
  • 18% of patients used PPIs at baseline, and 27% used PPIs concurrently with alendronate during follow-up. (annals.org)
  • New research has linked alendronate to reduced cardiovascular death in hip fracture patients. (the-rheumatologist.org)
  • In a recent study , alendronate was linked to a reduced risk of cardiovascular death, myocardial infarction and stroke in hip fracture patients. (the-rheumatologist.org)
  • We identified 283,586 alendronate patients and 40,463 raloxifene patients. (eur.nl)
  • So taking ALENDRONATE will organise your chance of a learning evaluation a Jefferson County ALENDRONATE had done of Frye in 1995, but that if you take steroids, you may have the gall inventor. (wanadoo.es)
  • It contains the active ingredient, alendronate (as alendronate sodium). (nps.org.au)
  • Alendronate and raloxifene have a similar hip fracture risk (hazard ratio [HR] 1.03, 95% confidence interval [CI] 0.94-1.13), but alendronate users are more likely to have vertebral fractures (HR 1.07, 95% CI 1.01-1.14). (eur.nl)
  • Alendronate increases the thickness of bone ( bone mineral density ) by slowing down the cells that usually break down bone ( osteoclasts ). (medbroadcast.com)
  • Alendronate reduces bone loss, increases bone density and reduces the risk of spine and non-spine fractures including hip fractures. (nof.org)
  • Women who received alendronate had fewer increases in the spine deformity index (33% vs 41%, P = 0.03) and had a lower mean loss of height (3.0 vs 4.6 mm, P = 0.005). (acpjc.org)
  • Alendronate with either 2,800 IU or 5,600 IU of vitamin D3 provides another option for a source of vitamin D. Weekly alendronate with 2,800 IU of vitamin D3 is the equivalent of taking 400 IU daily, while weekly alendronate with 5,600 IU of vitamin D3 is the equivalent of taking 800 IU daily. (nof.org)
  • Online pharmacies in our program do not offer Alendronate sodium/Cholecalciferol (vitamin d3) 70 mg/5600iu for sale, but you can find the discounted U.S. price below. (pharmacychecker.com)
  • Each white, oval, biconvex tablet engraved 'APO' on one side and 'ALE70' on the other contains 91.35 mg of alendronate sodium salt trihydrate, which is the molar equivalent of 70 mg of alendronate. (canada.com)
  • In addition to alendronate, DRONALEN PLUS also contains vitamin D, an essential nutrient required for calcium absorption and healthy bones. (news-medical.net)
  • Decreased alendronate absorption. (drugster.info)
  • Absorption of alendronate is decreased by food. (drugster.info)
  • She also said that, in and of themselves, the results weren't a reason to prefer zoledronic acid over alendronate. (medpagetoday.com)
  • Unless I saw a head-to-head trial with a difference in fracture rates at that point in time, I wouldn't [pick zoledronic acid over alendronate]," Shane said. (medpagetoday.com)
  • A team of Cochrane Researchers set out to evaluate the evidence behind the use of alendronate for primary and secondary prevention of bone fractures in these women. (innovations-report.com)
  • For prevention, alendronate is taken daily as a 5 mg tablet or weekly as a 35 mg tablet. (nof.org)
  • Raloxifene is as effective as alendronate and may remain an option in the prevention of osteoporotic fracture. (eur.nl)
  • Teriparatide increased hip BMD by 3.8% while it rose 2.4% in the alendronate group. (medpagetoday.com)
  • A 2006 study from Stanford University researchers found that teriparatide is less cost-effective than alendronate for postmenopausal women with severe osteoporosis. (medpagetoday.com)
  • That finding assumed that teriparatide was 35% more effective than alendronate in reducing fractures -- about the same as in the new study. (medpagetoday.com)
  • It does not contain all the information that is known about alendronate and colecalciferol. (nps.org.au)
  • It contains the active ingredients alendronate sodium and colecalciferol. (nps.org.au)
  • By making bones stronger, alendronate can help to reduce the incidence of osteoporosis-related fractures. (medbroadcast.com)
  • She noted that the biomarkers were "already highly suppressed" in the alendronate group at the six-week mark. (medpagetoday.com)
  • in the group 2 (G2) was used subcutenous alendronate (0.5 mg/kg) once for three weeks and then was realizd the both surgical techniques. (scielo.cl)
  • In group 3 (G3), after ovariectomy was realized the both dental extraction and the calvarium defect and after that was realized the alendronate protocol. (scielo.cl)
  • Group 2 (G2): 25 pt treated with alendronate for at least one year. (scielo.br)
  • BUA and Stiffness showed a significant increase in the alendronate-treated group at year 2 (3.2% and 4.9%, respectively) and at year 3 (3.8% and 6%, respectively). (nih.gov)
  • To claim your free Alendronate Sodium discount, view the available manufacturer coupons or patient assistance programs below or use the free buying group coupon to get a discount on Alendronate Sodium today. (internetdrugcoupons.com)
  • In the alendronate group (n = 3105), greater reductions in one or more biochemical marker were associated with a lower risk of fracture. (unboundmedicine.com)
  • Forty-eight postmenopausal women were enrolled in a 1-year prospective randomized trial and assigned to alendronate monotherapy (5 mg/day) (group A, n = 26) or vitamin K(2) (45 mg/day) plus alendronate (5 mg/day) (group AK, n = 22). (druglib.com)
  • ALENDRONATE (a LEN droe nate) slows calcium loss from bones. (ahealthyme.com)
  • Alendronate helps to treat and prevent osteoporosis only as long as it is taken regularly. (medlineplus.gov)
  • Alendronate is used to treat or prevent osteoporosis or bone thinning in men and post-menopausal women and Paget's disease or bone deformity. (medindia.net)
  • Alendronate and cholecalciferol is used to treat and prevent osteoporosis. (pardeehospital.org)
  • Do not take alendronate if you cannot sit upright or stand for at least 30 minutes after taking the medicine. (rexhealth.com)
  • Alendronate Sodium should not be used by persons who cannot sit upright or stand for more than 30 minutes. (genericdoctor.com)
  • Retrieved on November 29, 2020 from https://www.news-medical.net/news/20120919/Alendronate-decreases-BMD-loss-in-prostate-cancer.aspx. (news-medical.net)
  • Alendronate use is associated with an increased risk for atrial fibrillation in women. (greenmedinfo.com)