Alendronate
Bone Density Conservation Agents
Osteoporosis, Postmenopausal
Etidronic Acid
Diphosphonates
Organic compounds which contain P-C-P bonds, where P stands for phosphonates or phosphonic acids. These compounds affect calcium metabolism. They inhibit ectopic calcification and slow down bone resorption and bone turnover. Technetium complexes of diphosphonates have been used successfully as bone scanning agents.
Bone Density
The amount of mineral per square centimeter of BONE. This is the definition used in clinical practice. Actual bone density would be expressed in grams per milliliter. It is most frequently measured by X-RAY ABSORPTIOMETRY or TOMOGRAPHY, X RAY COMPUTED. Bone density is an important predictor for OSTEOPOROSIS.
Osteoporosis
Bone Remodeling
The continuous turnover of BONE MATRIX and mineral that involves first an increase in BONE RESORPTION (osteoclastic activity) and later, reactive BONE FORMATION (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium HOMEOSTASIS. An imbalance in the regulation of bone remodeling's two contrasting events, bone resorption and bone formation, results in many of the metabolic bone diseases, such as OSTEOPOROSIS.
Teriparatide
A polypeptide that consists of the 1-34 amino-acid fragment of human PARATHYROID HORMONE, the biologically active N-terminal region. The acetate form is given by intravenous infusion in the differential diagnosis of HYPOPARATHYROIDISM and PSEUDOHYPOPARATHYROIDISM. (Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Englewood, CO, 1995)
Bone and Bones
Raloxifene
Hydroxycholecalciferols
Fractures, Spontaneous
Collagen Type I
Tibia
Drugs, Generic
Bone Demineralization Technique
Lumbar Vertebrae
Geranyltranstransferase
Clodronic Acid
Intubation, Gastrointestinal
Calcification, Physiologic
Vitamin A
Retinol and derivatives of retinol that play an essential role in metabolic functioning of the retina, the growth of and differentiation of epithelial tissue, the growth of bone, reproduction, and the immune response. Dietary vitamin A is derived from a variety of CAROTENOIDS found in plants. It is enriched in the liver, egg yolks, and the fat component of dairy products.
Endocrine System Diseases
Pharmacists
Dairy Products
Tablets
Irritants
Drugs that act locally on cutaneous or mucosal surfaces to produce inflammation; those that cause redness due to hyperemia are rubefacients; those that raise blisters are vesicants and those that penetrate sebaceous glands and cause abscesses are pustulants; tear gases and mustard gases are also irritants.
Beverages
Saskatchewan
A province of Canada, lying between the provinces of Alberta and Manitoba. Its capital is Regina. It is entirely a plains region with prairie in the south and wooded country with many lakes and swamps in the north. The name was taken from the Saskatchewan River from the Cree name Kisiskatchewani Sipi, meaning rapid-flowing river. (From Webster's New Geographical Dictionary, 1988, p1083 & Room, Brewer's Dictionary of Names, 1992, p486)
Prostate
Prostate-Specific Antigen
Osteoporotic Fractures
Hip Fractures
Mixed Connective Tissue Disease
A syndrome with overlapping clinical features of systemic lupus erythematosus, scleroderma, polymyositis, and Raynaud's phenomenon. The disease is differentially characterized by high serum titers of antibodies to ribonuclease-sensitive extractable (saline soluble) nuclear antigen and a "speckled" epidermal nuclear staining pattern on direct immunofluorescence.
Dermatomyositis
A subacute or chronic inflammatory disease of muscle and skin, marked by proximal muscle weakness and a characteristic skin rash. The illness occurs with approximately equal frequency in children and adults. The skin lesions usually take the form of a purplish rash (or less often an exfoliative dermatitis) involving the nose, cheeks, forehead, upper trunk, and arms. The disease is associated with a complement mediated intramuscular microangiopathy, leading to loss of capillaries, muscle ischemia, muscle-fiber necrosis, and perifascicular atrophy. The childhood form of this disease tends to evolve into a systemic vasculitis. Dermatomyositis may occur in association with malignant neoplasms. (From Adams et al., Principles of Neurology, 6th ed, pp1405-6)
Connective Tissue Diseases
Absorptiometry, Photon
A noninvasive method for assessing BODY COMPOSITION. It is based on the differential absorption of X-RAYS (or GAMMA RAYS) by different tissues such as bone, fat and other soft tissues. The source of (X-ray or gamma-ray) photon beam is generated either from radioisotopes such as GADOLINIUM 153, IODINE 125, or Americanium 241 which emit GAMMA RAYS in the appropriate range; or from an X-ray tube which produces X-RAYS in the desired range. It is primarily used for quantitating BONE MINERAL CONTENT, especially for the diagnosis of OSTEOPOROSIS, and also in measuring BONE MINERALIZATION.
Cholecalciferol
Protective Devices
Spasm
Alendronate gastric ulcers. (1/413)
BACKGROUND: It appears likely that drugs other than NSAIDs may cause ulcers and ulcer complications (e.g. potassium chloride). Alendronate (Fosamax) is used in the treatment and prevention of metabolic bone disease and has also been associated with severe oesophageal damage and stricture. We have previously shown that the dose of alendronate used for Paget's disease (40 mg) causes gastric damage similar to NSAIDs. The usual dose for the treatment of postmenopausal osteoporosis is 10 mg per day. AIM: To investigate whether the 10 mg dose of alendronate causes gastric ulcers. METHODS: We performed an endoscopist-blind, crossover, randomized, single-centre comparison of 10 mg of alendronate/day and placebo in volunteers aged 40 years or more. Video-endoscopy was used to evaluate the presence and degree of mucosal damage to the oesophagus, stomach, or duodenal bulb after 7 and 14 days of treatment. RESULTS: Twenty-four healthy volunteers participated, including 15 women and nine men, ranging in age from 41 to 52 years. Visible gastric mucosal damage was present in nine (38%) who received alendronate compared to three (13%) in the placebo group. There was a marked difference in the severity of mucosal damage; there were no ulcers or large erosions in those receiving placebo. In contrast, potentially clinically significant gastric mucosal injury was seen in six subjects receiving alendronate (two developed antral ulcers and four had large (4-8 mm) superficial antral erosions) compared to none in the placebo group (P = 0.0219). One subject developed oesophageal damage in the form of multiple linear superficial erosions in the mid and distal oesophagus. Duodenal injury was not seen. CONCLUSION: Alendronate causes gastric ulceration, suggesting that alendronate use may be associated with ulcer complications such as acute upper gastrointestinal bleeding. The results of this study suggest the need for post-marketing surveillance to clarify the nature, frequency and magnitude of any potential gastrointestinal side-effects associated with the use of this drug. (+info)Clinic visits and hospital admissions for care of acid-related upper gastrointestinal disorders in women using alendronate for osteoporosis. (2/413)
CONTEXT: About 1 in 3 women taking alendronate for osteoporosis report gastrointestinal symptoms, a rate much higher than that found during clinical trials. OBJECTIVE: To establish the frequency of outpatient visits and hospital admissions for acid-related upper gastrointestinal disorder (ARD) among women taking alendronate and to identify potential risk factors. METHODS: A retrospective database analysis identified 812 women with osteoporosis who had filled one or more 10-mg alendronate prescriptions from October 1995 through October 1996. RESULTS: One hundred (12.3%) of the 812 women received healthcare for ARD, a clinical encounter rate of 28.5 per 100 person-years. A reference group of 362,109 women from the same health plan had 17.6 ARD encounters per 100 person-years. Excluding women who had ARDs before receiving alendronate, alendronate users were 1.6 (95% CI = 1.2, 2.7) times more likely to have an ARD encounter than nonusers. Risk of having ARD increased with age [users aged 70 years and older had a relative risk of 1.5 (95% confidence interval (CI) 1.0-2.30) compared with younger women] and with concurrent use of nonsteroidal anti-inflammatory drugs (NSAIDS) (relative risk 1.7, 95% CI 1.1-2.6). CONCLUSIONS: Elderly alendronate users or those concurrently taking NSAIDS should be carefully monitored because of their high risk of having ARD. Cost/benefit analyses of alendronate treatment for osteoporosis should include costs of treating ARD. (+info)Alendronate induces antinociception in mice, not related with its effects in bone. (3/413)
The antinociceptive effect of alendronate was studied. The bisphosphonate was i.p. administered and two tests were carried out: acetic acid in mice and formalin test in rats. In the acetic acid test, alendronate induced a dose-dependent antinociceptive effect that was statistically significant for the doses of 10, 20 and 40 mg/kg, and could be detected 48 hr after its administration. In the formalin test, however, alendronate, at the doses of 10 and 20 mg/kg, did not modify the pain score nor the number of flinches, when it was administered either 30 or 60 min before the test. However it must be noted that doses inducing analgesic effect are close to those inducing toxicity. (+info)Larger increases in bone mineral density during alendronate therapy are associated with a lower risk of new vertebral fractures in women with postmenopausal osteoporosis. Fracture Intervention Trial Research Group. (4/413)
OBJECTIVE: To investigate whether the incidence of vertebral fractures is related to the magnitude of change in bone mineral density (BMD) during alendronate treatment. METHODS: Women in this study were age 55-81 years (n = 2,984). While participating in the Fracture Intervention Trial, they received 5 mg/day of alendronate for 2 years followed by 10 mg/day for the remaining 12-30 months of the study. Their BMD was measured at baseline and at 12 and 24 months, and spine radiographs were obtained at baseline and again at 36 or 48 months to identify new vertebral fractures. RESULTS: After 12 months of alendronate treatment, 35% of participants had increases of > or =3% in total hip BMD, and 21% had either decreased total hip BMD or no change. Women who had larger increases in total hip BMD during the first 12 months had a lower incidence of new vertebral fractures during the entire followup period. Only 3.2% of women with increases of > or =3% in total hip BMD experienced new vertebral fractures, whereas twice as many women (6.3%) whose BMD declined or stayed the same experienced new fractures (adjusted odds ratio 0.45, 95% confidence interval 0.27-0.72). Similar patterns were observed for spine BMD at 12 months, and for both sites using change in BMD at 24 months. CONCLUSION: Women with increases of > or =3% in BMD during the first 1 or 2 years of alendronate treatment had the lowest incidence of new vertebral fractures. These findings suggest that, among women taking antiresorptive agents, greater increases in BMD are associated with lower risk of new vertebral fractures. (+info)Farnesol and geranylgeraniol prevent activation of caspases by aminobisphosphonates: biochemical evidence for two distinct pharmacological classes of bisphosphonate drugs. (5/413)
Recently, advances have been made in understanding the molecular mechanisms by which bisphosphonate drugs inhibit bone resorption. Studies with the macrophage-like cell line J774 have suggested that alendronate, an amino-containing bisphosphonate, causes apoptosis by preventing post-translational modification of GTP-binding proteins with isoprenoid lipids. However, clodronate, a nonaminobisphosphonate, does not inhibit protein isoprenylation but can be metabolized intracellularly to a cytotoxic, beta-gamma-methylene (AppCp-type) analog of ATP. These observations raise the possibility that bisphosphonates can be divided into two groups with distinct molecular mechanisms of action depending on the nature of the R2 side chain. We addressed this question by directly comparing the ability of three aminobisphosphonates (alendronate, ibandronate, and pamidronate) and three nonaminobisphosphonates (clodronate, etidronate, and tiludronate) to inhibit protein isoprenylation and activate caspase-3-like proteases or to be metabolized to AppCp-type nucleotides by J774 cells. All three aminobisphosphonates inhibited protein isoprenylation and activated caspase-3-like proteases. Apoptosis and caspase activation after 24-h treatment with the aminobisphosphonates could be prevented by addition of farnesol or geranylgeraniol, confirming that these bisphosphonates inhibit the metabolic mevalonate pathway. No AppCp-type metabolites of the aminobisphosphonates could be detected by mass spectrometry. The three nonaminobisphosphonates did not inhibit protein isoprenylation or cause activation of caspase-3-like proteases, but were incorporated into AppCp-type nucleotides. Taken together, these observations clearly demonstrate that bisphosphonate drugs can be divided into two pharmacological classes: the aminobisphosphonates, which act by inhibiting protein isoprenylation, and the less potent nonaminobisphosphonates, which act through the intracellular accumulation of AppCp-type metabolites. (+info)Use of bone alkaline phosphatase to monitor alendronate therapy in individual postmenopausal osteoporotic women. (6/413)
BACKGROUND: Biochemical bone markers are sensitive to the changes in bone turnover that result from treatment of postmenopausal osteoporotic women with antiresorptive therapies. Although information is available on the use of bone markers in monitoring therapy in groups of subjects, less is known regarding how these markers perform in individual patients. METHODS: Serum bone alkaline phosphatase (bone ALP) concentrations, measured with the Tandem(R) Ostase(R) assay, were used to monitor the biochemical response of bone in postmenopausal women with osteoporosis receiving either 10 mg/day alendronate therapy (n = 74) or calcium supplementation (n = 148) for 24 months. RESULTS: Bone ALP decreased significantly from baseline at 3 months (P +info)Prevention of osteoporosis and fractures. (7/413)
Osteoporosis and low bone density are associated with a risk of fracture as a result of even minimally traumatic events. The estimated lifetime risk of osteoporotic fracture is as high as 50 percent, especially in white and Asian women. The use of caffeine, tobacco and steroids is associated with a decrease in bone density. Cognitive impairment, vision problems and postural instability increase the risk of falling and sustaining a fracture. Medications such as long-acting sedative hypnotics, anticonvulsants and tricyclic antidepressants also increase this risk. Combinations of clinical and radiographic findings can predict fracture risk more effectively than bone densitometry, but often only after the first fracture has occurred. The addition of dietary calcium and/or vitamin D is clearly both cost-effective and significant in reducing the likelihood of fractures. Bisphosphonates reduce fracture risk but at a cost that may be prohibitive for some patients. Estrogen and estrogen-receptor modulators have not been well studied in randomized trials evaluating the reduction of fractures, but they are known to increase bone density. Pharmacologic therapy and the reduction of sensory and environmental hazards can prevent osteoporotic fractures in some patients. (+info)Prevention of osteocyte and osteoblast apoptosis by bisphosphonates and calcitonin. (8/413)
Glucocorticoid-induced osteoporosis may be due, in part, to increased apoptosis of osteocytes and osteoblasts, and bisphosphonates (BPs) are effective in the management of this condition. We have tested the hypothesis that BPs suppress apoptosis in these cell types. Etidronate, alendronate, pamidronate, olpadronate, or amino-olpadronate (IG9402, a bisphosphonate that lacks antiresorptive activity) at 10(-9) to 10(-6) M prevented apoptosis of murine osteocytic MLO-Y4 cells, whether it was induced by etoposide, TNF-alpha, or the synthetic glucocorticoid dexamethasone. BPs also inhibited apoptosis of primary murine osteoblastic cells isolated from calvaria. Similar antiapoptotic effects on MLO-Y4 and osteoblastic cells were seen with nanomolar concentrations of the peptide hormone calcitonin. The antiapoptotic effect of BPs and calcitonin was associated with a rapid increase in the phosphorylated fraction of extracellular signal regulated kinases (ERKs) and was blocked by specific inhibitors of ERK activation. Consistent with these in vitro results, alendronate abolished the increased prevalence of apoptosis in vertebral cancellous bone osteocytes and osteoblasts that follows prednisolone administration to mice. These results suggest that the therapeutic efficacy of BPs or calcitonin in diseases such as glucocorticoid-induced osteoporosis may be due, in part, to their ability to prevent osteocyte and osteoblast apoptosis. (+info)
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Alendronic acid
After absorption in the bone, alendronate has an estimated terminal elimination half-life of 10 years. "Alendronate Use During ... decrease the absorption of alendronate. At least half an hour should pass after intake of alendronate before eating dairy ... "Alendronate Sodium - Drug Usage Statistics". ClinCalc. Retrieved 18 February 2021. Sun K, Liu JM, Sun HX, Lu N, Ning G (October ... Bone: alendronate has been linked in long-term users to the development of low-impact femoral fractures. Further, studies ...
Effervescent tablet
EB (2015). "In Brief: Effervescent Alendronate". The Medical Letter on Drugs and Therapeutics. October 15, 2012. Baynes, T. S ...
Mevalonate kinase deficiency
"Weekly oral alendronate in mevalonate kinase deficiency". Orphanet Journal of Rare Diseases. 8: 196. doi:10.1186/1750-1172-8- ...
Teriparatide
November 2007). "Teriparatide or alendronate in glucocorticoid-induced osteoporosis". The New England Journal of Medicine. 357 ...
Gideon Rodan
This compound became known as Alendronate or Fosamax. In further works he examined the role of steroid in bone metabolism and ...
Schedule H
... is a class of prescription drugs in India appearing as an appendix to the Drugs and Cosmetics Rules, 1945 introduced in 1945. These are drugs which cannot be purchased over the counter without the prescription of a qualified doctor.The manufacture and sale of all drugs are covered under the Drugs and Cosmetics Act and Rules. It is revised at times based on the advice of the Drugs Technical Advisory Board, part of the Central Drugs Standard Control Organization[1] in the Ministry of Health and Family Welfare. The most recent schedule H (2006) lists 536 drugs from abacavir to zuclopenthixol.[2] However, enforcement of Schedule H laws in India is lax, compared to the more restrictive Schedule X, for which a mandatory documentation trail must be maintained.[3] ...
Discovery and development of bisphosphonates
Alendronate, a common bisphosphonate drug, has a three carbon length side chain for example. Risedronate has heterocyclic ... Alendronate localization in rat bone and effects on osteoclast ultrastructure". Journal of Clinical Investigation. 88 (6): 2095 ... Masarachia, P.; Weinreb, M.; Balena, R.; Rodan, G. A. (1996-09-01). "Comparison of the distribution of 3H-alendronate and 3H- ...
Hajdu-Cheney syndrome
Brand names include Actonel (risedronate/alendronate), made by Merck Pharmaceuticals. Other drugs include Pamidronate, made by ...
Paget's disease of bone
Alendronate sodium is given as tablets once daily for six months; patients should wait at least 30 minutes after taking before ...
Bisphosphonate
The bisphosphonate alendronate reduces the risk of hip, vertebral, and wrist fractures by 35-39%; zoledronate reduces the risk ... In the 1990s their actual mechanism of action was demonstrated with the initial launch of alendronate by Merck & Co. Not sold ... Wysowski D, Chang J (2005). "Alendronate and risedronate: reports of severe bone, joint, and muscle pain". Arch Intern Med. 165 ... In osteoporosis and Paget's, the most popular first-line bisphosphonate drugs are alendronate and risedronate. If these are ...
Riad Barmada
"Inhibition of particulate debris-induced osteolysis by alendronate in a rat model". Orthopedics. 25 (1): 59-63. PMID 11811243. ... Lysosomal Degranulation and IL-1 Release from Neutrophils Inhibition of particulate debris-induced osteolysis by alendronate in ...
Etidronic acid
For this reason, other bisphosphonates, such as alendronate, are preferred when fighting osteoporosis. To prevent bone ...
William H. Harris (orthopaedic surgeon)
Bragdon, C. R.; Doherty, A. M.; Jasty, M; Rubash, H; Harris, W. H. (2005). "Effect of oral alendronate on net bone ingrowth ...
Osteoporosis
Alendronate decreases fractures of the spine but does not have any effect on other types of fractures. Half stop their ... Wells GA, Cranney A, Peterson J, Boucher M, Shea B, Robinson V, Coyle D, Tugwell P (January 2008). "Alendronate for the primary ... "Osteoporosis - primary prevention (TA160) : Alendronate, etidronate, risedronate, raloxifene and strontium ranelate for the ... Certain medications like alendronate, etidronate, risedronate, raloxifene, and strontium ranelate can help to prevent ...
Mouth ulcer
Common examples are alendronate (a bisphosphonate, commonly prescribed for osteoporosis), cytotoxic drugs (e.g. methotrexate, i ... Kharazmi M, Sjöqvist K, Warfvinge G (April 2012). "Oral ulcers, a little known adverse effect of alendronate: review of the ...
Avascular necrosis
74-. ISBN 978-0-936923-24-6. Agarwala S, Jain D, Joshi VR, Sule A (March 2005). "Efficacy of alendronate, a bisphosphonate, in ...
Merck & Co.
Alendronate reduces the risk of hip, vertebral, and wrist fractures by 35-39%. In December 2013, Merck agreed to pay a total of ... Fosamax (alendronate) is a bisphosphonate used for the treatment of post-menopausal osteoporosis and for the prevention of ... "Systematic review and meta-analysis of the efficacy and safety of alendronate and zoledronate for the treatment of ... the North American Menopause Society and the UK National Osteoporosis Guideline Group recommend alendronate and certain other ...
Menopause
The bisphosphonate drug alendronate may decrease the risk of a fracture, in women that have both bone loss and a previous ... Wells GA, Cranney A, Peterson J, Boucher M, Shea B, Robinson V, Coyle D, Tugwell P (January 2008). "Alendronate for the primary ...
Geranyltranstransferase
FPPS is the target of bisphosphonate drugs such as Fosamax (alendronate) and Actonel (risedronate). Bisphosphonate drugs are ...
Osteosarcoma
Tomlin JL, Sturgeon C, Pead MJ, Muir P (29 July 2000). "Use of the bisphosphonate drug alendronate for palliative management of ... Some current studies indicate osteoclast inhibitors such as alendronate and pamidronate may have beneficial effects on the ...
Abaloparatide
Combined abaloparatide and alendronate therapy reduced significantly the incidence of vertebral and nonvertebral fractures. A ... received additional 2 years of 70 mg of alendronate, Vitamin D (400 to 800 IU), and calcium (500-1000 mg) supplementation daily ... "Eighteen Months of Treatment With Subcutaneous Abaloparatide Followed by 6 Months of Treatment With Alendronate in ...
Senile osteoporosis
Duque G, Rivas D (October 2007). "Alendronate has an anabolic effect on bone through the differentiation of mesenchymal stem ... along with alendronate, residronate, strontrium and zoledronic acid which have proven efficacy in primary and secondary hip ...
Fibrous dysplasia of bone
... placebo-controlled trial of alendronate treatment for fibrous dysplasia of bone". The Journal of Clinical Endocrinology and ...
Osteogenesis imperfecta
S2CID 19316414.Free full text DiMeglio LA, Peacock M (2006). "Two-year clinical trial of oral alendronate versus intravenous ... Some studies have found oral and intravenous bisphosphonates, such as oral alendronate and intravenous pamidronate, equivalent ... "Effects of oral alendronate on BMD in adult patients with osteogenesis imperfecta: a 3-year randomized placebo-controlled trial ...
Feline odontoclastic resorptive lesion
Use of alendronate has been studied to prevent TRs and decrease progression of existing lesions. True dental caries are ...
Chest pain
Medication such as nonsteroidal anti-inflammatory drug and alendronate can induce esophagitis if not swallowed properly. ...
Hematopoietic stem cell niche
Finally, osteoclast inhibition by the bisphosphonate alendronate has correlated with decreased HSCs and bone marrow engraftment ...
Bone biopsy
"Differential Effects of Teriparatide and Alendronate on Bone Remodeling in Postmenopausal Women Assessed by Histomorphometric ...
Medication-related osteonecrosis of the jaw
This type of drug has a high affinity for hydroxyapatite and stays in bone tissue for a long period of time, with alendronate, ... Examples of bisphosphonates: : Zoledronic acid (Reclast, Zometa), Risedronate (Actonel), Alendronate (Fosamax), Etidronate ( ... zoledronic acid and pamidronate and alendronate, risedronate, and ibandronate. Despite the fact that it remains vague as to ...
Alendronate: MedlinePlus Drug Information
Alendronate: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Continue to take alendronate even if you feel well. Do not stop taking alendronate without talking to your doctor, but talk to ... Before taking alendronate,. *tell your doctor and pharmacist if you are allergic to alendronate or any other medications. ... Talk to your doctor about the risks of taking alendronate.. Alendronate may cause other side effects. Call your doctor if you ...
Alendronate Sodium - Drugs.com
A list of US medications equivalent to Alendronate Sodium is available on the Drugs.com website. ... Alendronate Sodium is a medicine available in a number of countries worldwide. ... Ingredient matches for Alendronate Sodium. Alendronate. Alendronate Sodium (USAN) is known as Alendronate in the US. ... Alendronate Sodium. Alendronate Sodium may be available in the countries listed below. ...
ACTIVExtend Supports Value of Abaloparatide, Then Alendronate
"To say that this order is better for fracture efficacy, you would have had to have a group that got alendronate first, then ABL ... All participants who entered into the extension trial received alendronate 70 mg orally once a week for 24 months. A total of ... ACTIVE study investigators hope to demonstrate that the benefits of early ABL-SC will be maintained with the use of alendronate ... And we found that] the sequence of [subcutaneous abaloparatide, Radius Health] ABL-SC followed by 6 months of [alendronate] ALN ...
Alendronate Sodium Hainan - Drugs.com
A list of US medications equivalent to Alendronate Sodium Hainan is available on the Drugs.com website. ... Alendronate Sodium Hainan is a medicine available in a number of countries worldwide. ... Alendronate. Alendronic Acid sodium monohydrate (a derivative of Alendronic Acid) is reported as an ingredient of Alendronate ... Alendronate Sodium Hainan may be available in the countries listed below.. Ingredient matches for Alendronate Sodium Hainan. ...
alendronate
... is also used to treat Paget's disease of bone. Alendronate may also be used for purposes not listed in this ... Alendronate is used to treat osteoporosis caused by menopause, steroid use, or gonadal failure. This medicine is for use when ... Do not take alendronate if you cannot sit upright or stand for at least 30 minutes. Alendronate can cause serious problems in ... Alendronate can cause serious problems in the stomach or esophagus. Stop using alendronate and call your doctor at once if you ...
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Alendronate - Side effect(s)
Read the side effects of Alendronate as described in the medical literature. In case of any doubt consult your doctor or ... Alendronate - Information. Alendronate is used to treat or prevent osteoporosis or bone thinning in men and post-menopausal ... Side effect(s) of Alendronate Read the side effects of Alendronate as described in the medical literature. In case of any doubt ...
Alendronate (Oral Route) Before Using - Mayo Clinic
Information about this alendronate-oral-route. Pregnancy Category. Explanation. All Trimesters. C. Animal studies have shown an ... Alendronate may make these conditions worse. Proper Use. This medicine comes with a Medication Guide and a patient information ... Alendronate is used to prevent and treat osteoporosis (thinning of the bone) in women after menopause. This medicine may also ... Use of alendronate is not indicated in children. Geriatric Appropriate studies performed to date have not demonstrated ...
Alendronate decreases BMD loss in prostate cancer
Weekly administration of oral biphosphonate alendronate could reduce loss of bone mineral density in prostate cancer patients ... As reported in European Urology, the mean spine BMD increased by 1.7% from baseline in the alendronate group, compared with a ... Similarly, the mean total hip BMD increased by 0.7% in the alendronate group while it decreased by 1.6% in the placebo group. ... medwireNews: Weekly administration of oral biphosphonate alendronate could reduce loss of bone mineral density (BMD) in ...
DailyMed - ALENDRONATE- alendronate sodium tablet
Alendronate 5 mg/day % (n=642) Placebo % (n=648) Alendronate 5 mg/day % (n=361) Once Weekly Alendronate 35 mg % (n=362) ... Alendronate 10 mg/day % (n=146) Placebo % (n=95) Once Weekly Alendronate 70 mg % (n=109) Placebo % (n=58) ... See full prescribing information for alendronate sodium tablets, USP. Alendronate Sodium Tablets USP, for oral use Initial U.S ... Alendronate sodium * % (n=196) Placebo % (n=397) Alendronate sodium †% (n=3236) Placebo % (n=3223) ...
DailyMed - ALENDRONATE- alendronate sodium tablet
Alendronate 5 mg/day % (n=642) Placebo % (n=648) Alendronate 5 mg/day % (n=361) Once Weekly Alendronate 35 mg % (n=362) ... Alendronate 10 mg/day % (n=146) Placebo % (n=95) Once Weekly Alendronate 70 mg % (n=109) Once Weekly % (n=58) ... ALENDRONATE- alendronate sodium tablet. To receive this label RSS feed. Copy the URL below and paste it into your RSS Reader ... Alendronate sodium tablet works only if taken on an empty stomach. *Take alendronate sodium tablets, after you get up for the ...
Alendronate in Juvenile Osteoporosis - Study Results - ClinicalTrials.gov
Alendronate in Juvenile Osteoporosis. The safety and scientific validity of this study is the responsibility of the study ... Participants who have completed our earlier phase-1 and II study on alendronate in juvenile osteoporosis will be invited in ... Participants who earlier completed our phase I or phase II study on alendronate in juvenile osteoporosis, were invited to ... Participants who completed our earlier phase I/II study on alendronate in juvenile osteoporosis were invited to participate in ...
Dronalen Plus (Alendronate sodium/colecalciferol) Drug / Medicine Information
Alendronate sodium/colecalciferol) intended for persons living in Australia. ... Alendronate not only helps prevent the loss of bone but actually helps to rebuild bone and make bone less likely to fracture. ... The alendronate in DRONALEN PLUS works by slowing down the process of old bone being removed, which allows the bone-forming ... In addition to alendronate, DRONALEN PLUS also contains vitamin D, an essential nutrient required for calcium absorption and ...
Alendronate Osteoporosis Study - Full Text View - ClinicalTrials.gov
Alendronate Osteoporosis Study. The safety and scientific validity of this study is the responsibility of the study sponsor and ... Drug Information available for: Alendronate sodium Genetic and Rare Diseases Information Center resources: Dermatomyositis ... Double-Blinded Controlled Trial of Alendronate for the Treatment of Childhood and Adolescent Glucocorticoid- Associated ... treatment of glucocorticoid-associated osteopenia and osteoporosis with 18 months of alendronate (FOSAMAX®, Merck & Co., Inc.) ...
Alendronate (Binosto, Fosamax) | Davis's Drug Guide
Find information on Alendronate (Binosto, Fosamax) in Daviss Drug Guide including dosage, side effects, interactions, nursing ... alendronate is a topic covered in the Daviss Drug Guide. To view the entire topic, please log in or purchase a subscription. ... "Alendronate." Daviss Drug Guide, 16th ed., F.A. Davis Company, 2020. Washington Manual, www.unboundmedicine.com/ ... washingtonmanual/view/Davis-Drug-Guide/51022/all/alendronate. Vallerand AHA, Sanoski CAC, Quiring CC. Alendronate. Daviss Drug ...
Alendronate And Cholecalciferol (Oral Route) Proper Use - Mayo Clinic
Information about this alendronate-and-cholecalciferol-oral-route. Pregnancy Category. Explanation. All Trimesters. C. Animal ... Use of alendronate and cholecalciferol combination is not indicated in children. Geriatric Appropriate studies performed to ... Alendronate and cholecalciferol combination is used to treat osteoporosis (thinning of the bone) in women after menopause. This ... It is important that you tell all of your health care providers that you are taking alendronate and cholecalciferol combination ...
ASBMR: Zoledronic Acid Works Faster than Alendronate | Medpage Today
After six weeks, the zoledronic acid group averaged 26 ng/mL whereas the mean among patients taking alendronate was 37 ng/mL (P ... She noted that the biomarkers were "already highly suppressed" in the alendronate group at the six-week mark. "Im actually ... Source Reference: Hadji P, et al "The Rapid Onset and Sustained Efficacy (ROSE) study: zoledronic acid vs alendronate -- first ... She also said that, in and of themselves, the results werent a reason to prefer zoledronic acid over alendronate. ...
Testosterone and Alendronate in Hypogonadal Men - Full Text View - ClinicalTrials.gov
Placebo Comparator: Alendronate and Placebo Testosterone Drug: Alendronate Alendronate (Fosamax) 70mg every week. ... Drug: Placebo Alendronate A placebo alendronate tablet will be taken every week by subjects in the Testosterone and Placebo ... Experimental: Testosterone and Alendronate Drug: Testosterone Testosterone Gel (Fortesta) 40mg daily.. Drug: Alendronate ... Drug: Testosterone Drug: Alendronate Drug: Placebo Alendronate Drug: Placebo Testosterone Phase 2 ...
Teriparatide Found Superior to Alendronate in Steroid-Induced Osteoporosis | Medpage Today
... twice as much as oral alendronate (Fosamax) did in a head-to-head comparison ... In the randomized, double-blind trial, 428 patients were assigned to either 20 mcg of teriparatide or 10 mg of oral alendronate ... Teriparatide increased hip BMD by 3.8% while it rose 2.4% in the alendronate group. The advantage for teriparatide was ... Twice as many patients on teriparatide as on alendronate did not complete the planned therapy because of adverse effects. ...
Bilateral Femoral Insufficiency Fractures Likely Related to Long-Term Alendronate Therapy
Femoral insufficiency fractures after prolonged alendronate therapy seldom heal spontaneously. Alendronate acts as a strong ... Alendronate (Fosamax, Merck & company, inc.) is one of the first bisphosphonates to be licensed and used. There are several ... i)Long-term alendronate therapy is likely associated with femoral insufficiency fractures.(ii)Patients on more than 5 years of ... Alendronate (Fosamax) is one of the first bisphosphonates used to treat osteoporosis effectively. Recently, however, there is a ...
Alendronate trade name Fosamax | GreenMedInfo | Toxic Ingredient
This topic contains 27 study abstracts on Alendronate (trade name Fosamax) indicating it may contribute to Gastric Ulcer, ... Alendronate (trade name Fosamax) Related Articles. The Manufacturing of Bone Diseases: The Story of Osteoporosis and Osteopenia ... Problem Substances : Alendronate (trade name Fosamax) , Bisphosphonates, Zoledronic Acid. Adverse Pharmacological Actions : ... Problem Substances : Alendronate (trade name Fosamax) , Aspirin , Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), Pamidronate ...
Esophagus-enteric anastomosis ulceration caused by alendronate
Patient and Method A 63-year-old woman started medical therapy with alendronate in a dose of 10 mg daily. After a period of one ... Conclusion Alendronate sodium could cause lesions of the inferior esophageal portion or in distal segments of the ... Background Alendronate sodium is an aminobisphosphonate indicated for the treatment of osteoporosis in post-menopausal women ... Keywords : Alendronate; Esophageal stenosis; Anastomosis, Roux-en-Y; Esophagus [surgery]; Enteric ulceration. ...
Alendronate sodium / cholecalciferol | CADTH.ca
Alendronate can help prevent bone fractures in many postmenopausal women
Alendronate works by inhibiting the bone break down process.. By studying the outcomes of eleven trials that involved a total ... Giving 10mg per day of the bisphosphate drug alendronate to women after their menopause can help prevent loss of bone mass, ... A team of Cochrane Researchers set out to evaluate the evidence behind the use of alendronate for primary and secondary ... Alendronate can help prevent bone fractures in many postmenopausal women. 23.01.2008 ...
Bisphosphonates Zoledronate and Alendronate for the Management of Postmenopausal Osteoporosis
We review here two of the commonly used bisphosphonates zoledronate and alendronate. ... 2000) Therapeutic Equivalence of Alendronate 70 mg Once-Weekly and Alendronate 10 mg Daily in the Treatment of Osteoporosis. ... Chemical structure of alendronate is shown in Figure 2. Alendronate, for the treatment of osteoporosis is usually administered ... Alendronate Once-Weekly Study Group. Aging, 12, 1-12. [68] Ralston, S. (2015) Bisphosphonates for Osteoporosis. In: Harrison- ...
Alendronate-70 - Uses, Side Effects, Interactions - MedBroadcast.com
Alendronate belongs to a family of medications known as bisphosphonates. It is used to treat and prevent osteoporosis for ... Each white, oval, biconvex tablet engraved ALE70 on one side contains alendronate sodium equivalent to 70 mg of alendronate. ... Alendronate may also be used to treat and prevent steroid-induced osteoporosis for men and women (osteoporosis caused by taking ... Alendronate belongs to a family of medications known as bisphosphonates. It is used to treat and prevent osteoporosis for ...
Auro-Alendronate - Uses, Side Effects, Interactions - MedBroadcast.com
Alendronate belongs to a family of medications known as bisphosphonates. It is used to treat and prevent osteoporosis for ... 02388545 Auro-Alendronate 10 mg Tablet. 02388553 Auro-Alendronate 70 mg Tablet. ... Alendronate may also be used to treat and prevent steroid-induced osteoporosis for men and women (osteoporosis caused by taking ... Alendronate belongs to a family of medications known as bisphosphonates. It is used to treat and prevent osteoporosis for ...
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alendronate and cholecalciferol
Alendronate is a bisphosphonate (bis FOS fo nayt) medicine that alters bone formation and breakdown in the body. This can slow ... What is alendronate and cholecalciferol?. Alendronate is a bisphosphonate (bis FOS fo nayt) medicine that alters bone formation ... Alendronate and cholecalciferol is used to treat and prevent osteoporosis.. Alendronate and cholecalciferol may also be used ... Do not take this medicine tablet if you cannot sit upright or stand for at least 30 minutes. Alendronate can cause serious ...
APO-Alendronate Tablets
... is a brand of medicine containing the active ingredient Alendronic acid. Find out about side effects, ... The name of your medicine is APO-Alendronate Once Weekly. It contains the active ingredient, alendronate (as alendronate sodium ... What APO-Alendronate Once Weekly looks like. APO-Alendronate Once Weekly White, oval biconvex tablet, engraved APO on one side ... Alendronate is intended for use in postmenopausal women. You should not take alendronate if you are or think you may be ...
FosamaxBisphosphonatesBisphosphonateTabletsRisedronatePostmenopausal osteoporosisPlaceboEsophagusEffectiveness of alendronateDosage10mg70mgEffect of alendronate on boneLong-term alendronate therapyInteractionsTreat osteoporosisOralTreatmentSide effects of alendronateLumbarMonosodium salt trihydrateContains alendronate sodiumClinicalBone turnoverAllergic to alendronateDrugsMedicationsDosesFemoralDaily alendronateCalcium carbonatePatients1995IngredientFracture riskIncreasesVitamin D3TrihydrateAbsorptionZoledronicPreventionTeriparatideColecalciferolOsteoporosis-related fracturesGroupDroe natePrevent osteoporosisCannot sit upright or standDecreasesAtrial Fibrillation
Fosamax21
- DENVER -- Biochemical markers of bone turnover showed significantly faster responses on initiation of once-yearly zoledronic acid (Reclast) infusion than with weekly oral alendronate (Fosamax), researchers said here. (medpagetoday.com)
- Alendronate (Fosamax) 70mg every week. (clinicaltrials.gov)
- BIRMINGHAM, Ala., Nov. 15 -- For steroid-induced osteoporosis, injectable teriparatide (Forteo) increased bone-mineral density (BMD) twice as much as oral alendronate (Fosamax) did in a head-to-head comparison, investigators here found. (medpagetoday.com)
- Alendronate (Fosamax) is one of the first bisphosphonates used to treat osteoporosis effectively. (hindawi.com)
- Alendronate (Fosamax, Merck & company, inc.) is one of the first bisphosphonates to be licensed and used. (hindawi.com)
- Alendronate (frederick alendronate) - Order Alendronate (Fosamax)! (wanadoo.es)
- Grant me the pain killers for allowing me to go a few luminescence if ALENDRONATE is an added advantage of taking 10mg/day of Fosamax, 70mg once a month ago and have to take too much calcium in the lumbar spine and 5% in my 20's. (wanadoo.es)
- FOSAMAX PLUS D contains alendronate sodium, a bisphosphonate , and cholecalciferol ( vitamin D 3 ). (rxlist.com)
- FOSAMAX PLUS D for oral administration contains 91.37 mg of alendronate monosodium salt trihydrate, the molar equivalent of 70 mg of free acid, and 70 or 140 mcg of cholecalciferol, equivalent to 2800 or 5600 international units vitamin D, respectively. (rxlist.com)
- For most osteoporotic women, the appropriate dose is FOSAMAX PLUS D (70 mg alendronate/5600 international units vitamin D 3 ) once weekly. (rxlist.com)
- Waiting less than 30 minutes, or taking FOSAMAX PLUS D with food, beverages (other than plain water) or other medications will lessen the effect of alendronate by decreasing its absorption into the body. (rxlist.com)
- What is Fosamax (Alendronate) used for? (everydayhealth.com)
- Can I take Fosamax (Alendronate) if I'm pregnant or breastfeeding? (everydayhealth.com)
- Use Fosamax (Alendronate) exactly as directed on the label, or as prescribed by your doctor. (everydayhealth.com)
- Merck makes the medication, and it also sells a formula called Fosamax Plus D, which combines the active ingredient in Fosamax, alendronate sodium, with vitamin D 3 . (drugwatch.com)
- Fosamax (alendronate sodium) belongs to a drug class called bisphosphonates. (drugwatch.com)
- Fosamax plus consists of both Alendronate and Cholecalciferol. (canadapharmacy.com)
- Examples include: Alendronate,(Fosamax)Risedronate (Actonel, Atelvia)Ibandronate (Boniva)Zoledronic acid (Reclast)Side effects include nausea, abdominal pain, difficulty swallowing, and the risk of an inflamed esophagus or esophageal ulcers. (glogster.com)
- Fosamax generic (Alendronate) 70 mg, 35 mg. (combustiblecelluloid.com)
- Cost effectiveness of alendronate (fosamax) for the treatment of osteoporosis and prevention of fractures. (lu.se)
- Pallor is found among people who take Alendronate sodium, especially for people who are female, 60+ old , have been taking the drug for 1 - 6 months, also take medication Fosamax, and have High blood pressure. (ehealthme.com)
Bisphosphonates12
- Alendronate is in a class of medications called bisphosphonates. (medlineplus.gov)
- The alendronate in DRONALEN PLUS belongs to a group of non-hormonal medicines called bisphosphonates. (news-medical.net)
- Given the available evidence," Dr. Sambrook wrote, "the first choice for prevention would be a potent oral bisphosphonate such as alendronate or risedronate (Actonel) or, for patients who cannot tolerate oral bisphosphonates, an intravenous bisphosphonate, with calcium and vitamin D as adjunctive therapy. (medpagetoday.com)
- There are several studies showing the benefits of alendronate and other bisphosphonates. (hindawi.com)
- We review here two of the commonly used bisphosphonates zoledronate and alendronate. (scirp.org)
- Radwan, I. , Korany, N. and Ezzat, B. (2018) Bisphosphonates Zoledronate and Alendronate for the Management of Postmenopausal Osteoporosis. (scirp.org)
- In the current review, the antiresorptive bisphosphonates zoledronate and alendronate will be reviewed. (scirp.org)
- Alendronate sodium is one of the most potent oral bisphosphonates. (scielo.br)
- Alendronate belongs to the group of medicines called bisphosphonates. (canadapharmacy.com)
- Alendronate sodium belongs to the family of drugs called bisphosphonates. (healthboard.com)
- 38 088 patients ≥ 35 years of age (mean age 70 y, 83% women) who started alendronate between 1996 and 2005 (index date = date of first prescription for alendronate) and had not previously filled a prescription for antiosteoporotic drugs (bisphosphonates, selective estrogen-receptor modulators, parathyroid hormone analogues, or strontium ranelate). (annals.org)
- Alendronate belongs to a group of medications called bisphosphonates, which work by preventing bone breakdown and increasing bone density. (rxwiki.com)
Bisphosphonate6
- Participants in both the placebo and the ABL-SC arms were then invited to continue with active treatment in the form of the bisphosphonate alendronate so as to assess the long-term safety of ABL-SC. (medscape.com)
- Alendronate is a bisphosphonate (bis FOS fo nayt) medicine that alters bone formation and breakdown in the body. (pardeehospital.org)
- Alendronate sodium is a bisphosphonate that acts as a specific inhibitor of osteoclast -mediated bone resorption . (rxlist.com)
- Alendronate sodium hydrate (alendronate) is a bisphosphonate that potently inhibits bone resorption and is used to treat osteoporosis. (dovepress.com)
- To improve the transdermal bioavailability and safety of alendronate (ALN), a nitrogen-containing bisphosphonate, we developed self-dissolving microneedle arrays (MNs), in which ALN is loaded only at the tip portion of micron-scale needles by a dip-coating method (ALN(TIP)-MN). (mdpi.com)
- Bisphosphonate alendronate (ALN), phytoestrogen 8-prenylnaringenin (8-PN) and the whole body vibration exert a favorable effect on osteoporotic bone. (galileo-training.com)
Tablets10
- If you are taking the alendronate tablets, swallow the tablet with a full glass (6 to 8 ounces [180 to 240 mL]) of plain water. (medlineplus.gov)
- If you are taking the alendronate effervescent tablets, dissolve one effervescent tablet in a full glass (4 ounces [120 milliliters]) of plain, non-carbonated drinking water before drinking. (medlineplus.gov)
- These highlights do not include all the information needed to use Alendronate Sodium Tablets safely and effectively. (nih.gov)
- See full prescribing information for alendronate sodium tablets, USP. (nih.gov)
- Alendronate sodium tablets, USP are indicated for the treatment of osteoporosis in postmenopausal women. (nih.gov)
- In postmenopausal women, alendronate sodium tablets, USP increase bone mass and reduces the incidence of fractures, including those of the hip and spine (vertebral compression fractures). (nih.gov)
- Alendronate and cholecalciferol tablets are taken once each week. (pardeehospital.org)
- Please read this leaflet carefully before you start using APO-Alendronate Tablets. (nps.org.au)
- Alendronate and cholecalciferol tablets need to be taken once every week. (canadapharmacy.com)
- Please read this leaflet carefully before you start using Alendronate Plus D3 Sandoz 70 mg/140 mcg Tablets. (nps.org.au)
Risedronate5
- Presents a letter to the editor in response to the article about the comparison of the effect of alendronate and risedronate on the upper gastrointestinal mucosa by endoscopy. (ebscohost.com)
- The objective of the study was to compare the effects of alendronate, risedronate and calcitonin on biochemical markers of bone turnover and bone mineral density (BMD) in postmenopausal osteoporosis. (iospress.com)
- The patients (n=200) were equally divided to one of four treatment groups: alendronate 10 mg/daily, risedronate 5 mg/daily, calcitonin 200 IU/daily and control group for 12 months. (iospress.com)
- The treatment with alendronate produced significantly greater increases in total hip BMD than did risedronate and calcitonin and tretment with risedronate produced significantly greater increases in lumbar spine BMD than did alendronate and calcitonin over 12 months. (iospress.com)
- This study demonstrated the efficacy of alendronate, risedronate and calcitonin in preventing the bone loss related to postmenopausal osteoporosis. (iospress.com)
Postmenopausal osteoporosis3
- She had been receiving alendronate therapy for postmenopausal osteoporosis for 10 years. (hindawi.com)
- We hypothesized that administration of MK-677, an orally active GH secretagogue, together with alendronate, a potent inhibitor of bone resorption, would maintain a higher bone formation rate relative to that seen with alendronate alone, thereby generating greater enhancement of bone mineral density (BMD) in women with postmenopausal osteoporosis. (nih.gov)
- Effect of oral alendronate on bone mineral density and the incidence of fractures in postmenopausal osteoporosis. (acpjc.org)
Placebo25
- At the preplanned 6-month interim analysis, investigators documented no new vertebral fractures among women who had transitioned from daily ABL-SC to alendronate (ABL-SC/ALN) in the extension study vs seven new vertebral fractures in placebo patients who also received alendronate (PBO/ALN) in ACTIVExtend. (medscape.com)
- The team conducted an intention-to-treat analysis of 167 patients initiating ADT therapy (leuprolide acetate 30 mg intramuscularly every 4 months), who were randomly allocated to receive either once-weekly oral alendronate 70 mg or placebo. (news-medical.net)
- As reported in European Urology , the mean spine BMD increased by 1.7% from baseline in the alendronate group, compared with a 1.9% decrease from baseline in the placebo group. (news-medical.net)
- Similarly, the mean total hip BMD increased by 0.7% in the alendronate group while it decreased by 1.6% in the placebo group. (news-medical.net)
- The bone resorption marker, cross-linked N-telopeptide of type I collagen (Ntx), was decreased by a median of 3.5% in the alendronate group and increased by a median of 16.5% in the placebo group. (news-medical.net)
- Furthermore, bone-specific alkaline phosphatase, a marker of bone formation and turnover, was decreased by a median of 2.25% in the alendronate group and increased by a median of 3.12% in those who took placebo. (news-medical.net)
- Participants earlier were treated with alendronate for 12 months either in an open label study (without control) or double blind study with placebo control. (clinicaltrials.gov)
- A placebo alendronate tablet will be taken every week by subjects in the Testosterone and Placebo Alendronate Group. (clinicaltrials.gov)
- Placebo testosterone gel will be applied daily by subjects in the Alendronate and Placebo Testosterone group. (clinicaltrials.gov)
- A Phase 1 Randomized, Double-Blind, Placebo-Controlled Single and Multiple Ascending Dose Study of the Safety and Tolerability of Intravenous LLP2A-Alendronate in Adult Men and Women with Osteopenia Secondary to Corticosteroids. (clinicaltrials.gov)
- Patients who received MK-677 alone or placebo through month 12 received MK-677 (25 mg) plus alendronate (10 mg) from months 12-18. (nih.gov)
- We conducted a double-blinded, randomized trial comparing alendronate (10 mg daily) with placebo in 32 adolescents with anorexia nervosa (mean age, 16.9 +/- 1.9 yr). (nih.gov)
- We conclude that in adolescents with anorexia nervosa, weight restoration is the most important determinant of BMD, but treatment with alendronate did increase the BMD of the lumbar spine and femoral neck within the group receiving alendronate, but not compared with placebo in the primary analysis. (nih.gov)
- We used data from the Fracture Intervention Trial to assess the relationship change in bone turnover after 1 year of alendronate or placebo treatment and subsequent hip, non-spine, and spine fracture risk among 6186 postmenopausal women. (unboundmedicine.com)
- We measured biochemical markers of bone turnover (bone-specific alkaline phosphatase [bone ALP], intact N-terminal propeptide of type I collagen, and C-terminal crosslinked telopeptide of type 1 collagen) and BMD of the spine and hip at baseline and after 1 year of alendronate or placebo. (unboundmedicine.com)
- Prevention of Glucocorticoid-Induced Osteoporosis in Immunobullous Diseases With Alendronate: A Randomized, Double-blind, Placebo-Controlled Study. (druglib.com)
- Interventions The patients were randomized to receive either oral alendronate sodium (10 mg/d) or a matching placebo for 12 months. (druglib.com)
- RESULTS: A total of 29 patients (alendronate [n = 15], placebo [n = 14]) were evaluated. (druglib.com)
- The percent change in BMD in the alendronate group was +3.7% and +3.5% at the lumbar spine and the femoral neck, respectively, whereas in the placebo group, it was -1.4% and -0.7% at the lumbar spine and the femoral neck, respectively. (druglib.com)
- The increase in BMD observed in the alendronate group compared with the placebo group was statistically significant at both the lumbar spine (P = .01) and the femoral neck (P = .01). (druglib.com)
- 01) in the alendronate group but not in the placebo group. (druglib.com)
- placebo data were compared with data from the women who received all alendronate doses combined. (acpjc.org)
- Women in all 3 alendronate groups had significant increases in bone mineral density compared with women in the placebo group, who had significant decreases in bone mineral density. (acpjc.org)
- 1.0 commenced on alendronate/calcium (10 mg/600 mg day) or placebo/calcium, in a double blind randomized controlled trial. (monash.edu)
- 66 alendronate/calcium, 79 placebo/calcium with 24 and 26 withdrawals, respectively. (monash.edu)
Esophagus9
- Alendronate may not work properly and may damage the esophagus (tube between the mouth and stomach) or cause sores in the mouth if it is not taken according to the following instructions. (medlineplus.gov)
- You should not take alendronate if you have problems with your esophagus, or low levels of calcium in your blood. (rexhealth.com)
- Alendronate can cause serious problems in the stomach or esophagus. (rexhealth.com)
- Objective Report a case of a patient who underwent total gastrectomy with Y-en-Roux anastomosis for a gastric carcinoid tumor and developed an esophagus-enteric anastomosis ulceration after the use of alendronate. (scielo.br)
- Alendronate can cause serious problems in the stomach or esophagus (the tube that connects your mouth and stomach). (pardeehospital.org)
- This careful dosing is necessary to ensure that the alendronate is absorbed, and to minimize the risk of irritation of the esophagus. (nof.org)
- Are allergic to alendronate, have low levels of calcium in your blood (hypocalcemia), or a problem with the movement of muscles in your esophagus. (canadapharmacy.com)
- It is important that you take alendronate exactly as prescribed to help lower your chance of getting esophagus problems. (rxwiki.com)
- Some people who take alendronate/cholecalciferol may develop problems in the esophagus (the tube that connects the mouth and the stomach). (rxwiki.com)
Effectiveness of alendronate5
- Do proton-pump inhibitors (PPIs) reduce the effectiveness of alendronate for preventing hip fractures? (annals.org)
- PPI use did not attenuate the effectiveness of alendronate for preventing forearm (4.5/1000 patient-y in PPI users vs 4.3/1000 patient-y in nonusers), humerus (2.9 vs 2.5/1000 patient-y), or spine (2.7 vs 1.3/1000 patient-y) fractures. (annals.org)
- Concurrent use of proton-pump inhibitors, particularly at ≥ 1 dose-year, was associated with reduced effectiveness of alendronate for preventing hip fractures in older adults. (annals.org)
- Finally, the effectiveness of alendronate as a therapy for postmenopausal women with established osteoporosis should not be used to infer that alendronate would also prevent bone loss from estrogen deficiency. (acpjc.org)
- We studied the comparative effectiveness of alendronate (AL) and zoledronic acid (ZOL) on bone mass improvement in transfusion-dependent thalassemia (TDT) patients a year after treatment. (springer.com)
Dosage1
- The recommended dosage is one 70 mg alendronate/2800 international units vitamin D 3 or one 70 mg alendronate/5600 international units vitamin D 3 tablet once weekly. (rxlist.com)
10mg1
- Giving 10mg per day of the bisphosphate drug alendronate to women after their menopause can help prevent loss of bone mass, reducing their risk of fractures, a Cochrane Review has found. (innovations-report.com)
70mg2
- Effect of gradual accumulation of coronary artery calcium than those taking the 70mg awfully a pemphigus despondently of the Actonel clinical studies, fractures were reduced 65% in the 25-milligram jevons ALENDRONATE had 1. (wanadoo.es)
- Find other class related drugs CVS Pharmacy Patient Statistics for Alendronate: Oral tablet, weekly(70mg). (masterplumbers.com)
Effect of alendronate on bone2
- In conclusion, the anabolic effect of GH, as produced through the GH secretagogue MK-677, attenuated the indirect suppressive effect of alendronate on bone formation, but did not translate into significant increases in BMD at sites other than the femoral neck. (nih.gov)
- BMD at the lumbar spine appears to be the best method for monitoring the effect of alendronate on bone mass in osteoporotic men. (nih.gov)
Long-term alendronate therapy3
- Recently, however, there is a concern regarding long bone insufficiency fractures related to long-term alendronate therapy. (hindawi.com)
- We report a case of bilateral femoral insufficiency fractures likely related to long-term alendronate therapy, the classic symptoms, signs, and treatment of these fractures. (hindawi.com)
- We present a case of bilateral femoral shaft insufficiency fractures secondary to long-term alendronate therapy. (hindawi.com)
Interactions3
- Other beverages (including mineral water), food, and some medications are likely to reduce the absorption of alendronate [see DRUG INTERACTIONS ]. (rxlist.com)
- This is not a complete list of alendronate drug interactions. (rxwiki.com)
- Alendronate Sodium has interactions with calcium supplements/ antacids, aspirin, and non-steroidal anti-inflammatory drugs. (genericdoctor.com)
Treat osteoporosis6
- Alendronate is used to treat and prevent osteoporosis (a condition in which the bones become thin and weak and break easily) in women who have undergone menopause (''change of life,'' end of menstrual periods) and to treat osteoporosis in men. (medlineplus.gov)
- Alendronate is also used to treat osteoporosis in men and women who are taking corticosteroids (a type of medication that may cause osteoporosis in some patients). (medlineplus.gov)
- Alendronate is used to treat osteoporosis caused by menopause, steroid use, or gonadal failure. (rexhealth.com)
- Alendronate is used to prevent and treat osteoporosis (thinning of the bone) in women after menopause. (mayoclinic.org)
- When used for postmenopausal women, the recommended dose of alendronate to treat osteoporosis is one 10 mg tablet daily or 70 mg once weekly. (medbroadcast.com)
- Alendronate is a prescription medication used to treat osteoporosis and Paget's disease in men and women. (rxwiki.com)
Oral12
- If you are taking the alendronate oral solution, drink at least 2 ounces (60 milliliters [1/4 cup]) of water after taking alendronate oral solution. (medlineplus.gov)
- Weekly administration of oral biphosphonate alendronate could reduce loss of bone mineral density (BMD) in prostate cancer patients who start androgen-deprivation therapy (ADT), show study findings. (news-medical.net)
- They were randomized in a 2:1 ratio to 5 mg of zoledronic acid delivered in a single infusion or weekly treatment with 70 mg of oral alendronate. (medpagetoday.com)
- In the randomized, double-blind trial, 428 patients were assigned to either 20 mcg of teriparatide or 10 mg of oral alendronate daily for 18 months. (medpagetoday.com)
- deficiencies in re-epithelialization of oral mucosa show the impact of alendronate before dental extraction. (scielo.cl)
- deficiencias en la re epitelización de la mucosa oral muestran el impacto del alendronato después de la exodoncia. (scielo.cl)
- Once-weekly alendronate oral jelly was approved in 2012 by the Ministry of Health, Labour, and Welfare of Japan as the world's first drug for osteoporosis in a jelly formulation. (dovepress.com)
- In this review, this new formulation of alendronate sodium hydrate (oral jelly) is introduced and discussed in terms of osteoporosis treatment. (dovepress.com)
- Older adults taking alendronate and oral glucocorticoids are at a lower risk for nonvertebral fracture, including hip fracture , according to a retrospective cohort study published in the Journal of Endocrinology & Metabolism . (endocrinologyadvisor.com)
- OBJECTIVE: To evaluate the efficacy and safety of oral alendronate sodium therapy once daily in preventing glucocorticoid-induced bone loss in patients with immunobullous skin diseases treated with long-term glucocorticoid therapy. (druglib.com)
- To determine whether oral alendronate increases bone mineral density and decreases the incidence of vertebral fractures and loss of height in postmenopausal women with osteoporosis. (acpjc.org)
- Intravenous ranitidine increases the oral bioavailability of alendronate. (wikipedia.org)
Treatment22
- And we found that] the sequence of [subcutaneous abaloparatide, Radius Health] ABL-SC followed by 6 months of [alendronate] ALN improved BMD and reduced fracture risk throughout the skeleton and is likely to be a highly effective treatment option for postmenopausal women at risk for osteoporosis-related fractures," they note. (medscape.com)
- Participants who earlier completed in our open labeled or double blind study of alendronate treatment for juvenile osteoporosis, were invited for one clinical visit. (clinicaltrials.gov)
- However, treatment discontinuation because of adverse events was substantially more common in the alendronate group (10% versus 1%, P not reported). (medpagetoday.com)
- Teriparatide has an estimated annual treatment cost of nearly $7,000, about eight times as much as for alendronate. (medpagetoday.com)
- Background Alendronate sodium is an aminobisphosphonate indicated for the treatment of osteoporosis in post-menopausal women and has been associated with esophagitis in many reports. (scielo.br)
- Results - Medical treatment with alendronate was discontinued and the symptom of abdominal pain desapeared. (scielo.br)
- Alendronate is approved for the prevention and treatment of osteoporosis in postmenopausal women and for the treatment of osteoporosis in men. (nof.org)
- To assess bone turnover markers (BTM) and bone mineral density (BMD) after discontinuation of alendronate treatment used for five or more years. (scielo.br)
- A prospective open-labeled trial was conducted to compare the effects of short-term combined treatment with alendronate (ALN) and ECT on bone mineral density (BMD) and bone turnover with those of single treatment with ALN in postmenopausal women with osteoporosis. (dovepress.com)
- This study provides evidence that treatment with alendronate in this defined range of osteopenic patients prevents incident fractures in those who have prevalent VFs. (ebscohost.com)
- The aim of this study was to evaluate the effect of a 3-year alendronate treatment on bone mineral density (BMD) and quantitative ultrasound (QUS) in men with primary osteoporosis. (nih.gov)
- We studied 77 osteoporotic men (aged 57.1 +/- 10.8 yrs) who completed a 3-year treatment with alendronate (10 mg/day) plus calcium (1000 mg/day) (n = 39), or calcium alone (n = 38). (nih.gov)
- Alendronate treatment had significantly increased lumbar spine BMD by 4.2% at year 1, by 6.3% at year 2, and 8.8% at year 3. (nih.gov)
- If you have low blood calcium before you start taking alendronate, it may get worse during treatment. (rxwiki.com)
- Use of PPIs at baseline (prescription filled ≤ 12 mo before index date) or concurrent with alendronate (prescription filled during first 36 mo of treatment with alendronate). (annals.org)
- Teriparatide (TPTD) and alendronate (ALN) are widely used in clinical for treatment of osteoporosis. (bmj.com)
- Effects of continuing or stopping alendronate after 5 years of treatment: the Fracture Intervention Trial Long-term Extension (FLEX): a randomized trial. (bmj.com)
- Q In postmenopausal women with low bone mineral density (BMD) who had been receiving daily alendronate for a mean of 5 years, what is the effect of continuing alendronate treatment for 5 years compared with discontinuing it? (bmj.com)
- Alendronate Sodium is a medicine used in the treatment and prevention of osteoporosis which is caused by the use of steroids or menopause. (genericdoctor.com)
- Four patients discontinued alendronate therapy, and we analyzed the remaining 44 patients (23 in group A and 21 in group AK) who completed 1 year of treatment. (druglib.com)
- We conducted a randomized, multicenter, open-label trial to compare the efficacy of alendronate, calcitriol, and simple vitamin D in prevention and treatment of glucocorticoid-induced bone loss. (garvan.org.au)
- These data do not suggest any difference between simple vitamin D and calcitriol but do show that alendronate was superior to either treatment for glucocorticoid induced bone loss. (garvan.org.au)
Side effects of alendronate2
- Read the side effects of Alendronate as described in the medical literature. (medindia.net)
- These are not all the possible side effects of alendronate. (rxwiki.com)
Lumbar3
- However, similar enhancement was not seen with MK-677 plus alendronate in BMD of the lumbar spine, total hip, or total body compared with alendronate alone. (nih.gov)
- CONCLUSIONS: There were statistically significant increases in BMD at both the lumbar spine (P = .01) and the femoral neck (P = .01) with alendronate therapy. (druglib.com)
- Conclusions:Improvement in bone mineral density has been demonstrated at the lumbar spine, but not hip, by per protocol analysis, with daily alendronate, at 12 months. (monash.edu)
Monosodium salt trihydrate3
- Alendronate sodium is chemically described as (4-amino-1-hydroxybutylidene) bisphosphonic acid monosodium salt trihydrate. (rxlist.com)
- Each white, round, flat-faced, bevelled-edged tablet engraved 'A' on one side and '5' on the other contains 6.53 mg of alendronate monosodium salt trihydrate, which is the molar equivalent of 5 mg of alendronate. (canada.com)
- Each tablet contains 13.05 mg of alendronate monosodium salt trihydrate, which is the molar equivalent of 10 mg of alendronate. (canada.com)
Contains alendronate sodium2
- Each white, oval, biconvex tablet engraved 'ALE70' on one side contains alendronate sodium equivalent to 70 mg of alendronate. (medbroadcast.com)
- Each white, round, biconvex tablet engraved 'APO' on one side and '10' on the other contains alendronate sodium equivalent to alendronate 10 mg. (canada.com)
Clinical3
- I feel like to remind that ALENDRONATE has remove the service tax from Clinical Research in the paper would have been diagnosed with Osteoporosis 6 years ago and have been recalcitrant, with Merck winning 2 cases, losing 2 and receiving a split biochemistry on a daily basis, and they all are abusers. (wanadoo.es)
- If the clinical assessment of the o'connor o'sullivan limits the confidence with which a monaural sound that is impaired in alendronate diabetes. (dsaj.org)
- Until additional studies have demonstrated efficacy and long-term safety, the use of alendronate in this population should be confined to controlled clinical trials. (nih.gov)
Bone turnover5
- Observed BMD loss and BTM rise after alendronate withdrawal imply that bone turnover was not over suppressed, and alendronate discontinuation may not be safe. (scielo.br)
- Effect of alendronate and MK-677 (a growth hormone secretagogue), individually and in combination, on markers of bone turnover and bone mineral den. (nih.gov)
- We conclude that greater reductions in bone turnover with alendronate therapy are associated with fewer hip, non-spine, and vertebral fractures, and the effect is at least as strong as that observed with 1-year change in BMD. (unboundmedicine.com)
- the effect of long-term alendronate on bone turnover and strength is unknown ( 1 ). (acpjc.org)
- Alendronate decreases the risk of femoral neck fracture by suppressing bone turnover, and also decreases the serum total osteocalcin level. (druglib.com)
Allergic to alendronate1
- tell your doctor and pharmacist if you are allergic to alendronate or any other medications. (medlineplus.gov)
Drugs2
- Explain that certain side effects in this study were more common with teriparatide than with other osteoporosis drugs, and the dropout rate was higher for teriparatide than for alendronate. (medpagetoday.com)
- Food and drugs containing large amounts of calcium, magnesium or aluminium (antacids) decrease the absorption of alendronate. (wikipedia.org)
Medications3
- After you take alendronate, do not eat, drink, or take any other medications (including vitamins or antacids) for at least 30 minutes. (medlineplus.gov)
- Glucocorticoids are often administered with osteoporosis medications , most commonly alendronate, to prevent fractures. (endocrinologyadvisor.com)
- Alendronate and raloxifene are among the most popular anti-osteoporosis medications. (eur.nl)
Doses3
- Higher Alendronate / cholecalciferol doses were again correlated with fewer severe bone, joint, or dystrophic muscle pain collected continuously during the monitoring stay. (todaysparentusa.com)
- Risk of upper GI adverse reactions is increased by concomitant use of aspirin and alendronate doses over 10 mg/day. (drugster.info)
- But while pyrophosphate inhibits both osteoclastic bone resorption and the mineralization of the bone newly formed by osteoblasts, alendronate specifically inhibits bone resorption without any effect on mineralization at pharmacologically achievable doses. (wikipedia.org)
Femoral4
- Alendronate use is associated with low-energy femoral shaft fractures. (greenmedinfo.com)
- Although the femoral neck is an important site for fracture prevention, the lack of enhancement in bone mass at other sites compared with that seen with alendronate alone is a concern when weighed against the potential side effects of enhanced GH secretion. (nih.gov)
- Alendronate monotherapy does not decrease carboxylation of osteocalcin, and combination of vitamin K(2) and alendronate brings further benefits on both osteocalcin carboxylation and BMD of femoral neck in postmenopausal women with osteoporosis. (druglib.com)
- Bone: alendronate has been linked in long-term users to the development of low-impact femoral fractures. (wikipedia.org)
Daily alendronate1
- Our aim was to identify patients with low bone mineral density (BMD) using a screening program, and then evaluate the benefit of daily alendronate. (monash.edu)
Calcium carbonate1
- or alendronate, 10 mg/day plus calcium carbonate (600 mg daily). (garvan.org.au)
Patients16
- Check with your doctor 321 patients with rheumatoid most COMMON side alendronate 70 mg cost was no difference in when using Betamethasone Acne clumsiness dizziness facial flushing treated with 200 mg increased appetite increased sweating capsules once a day swelling or redness at Ketoprofen immediate release capsules upset stomach. (libero.it)
- Alendronate sodium is not indicated for use in pediatric patients. (nih.gov)
- Explain to interested patients that both zoledronic acid and alendronate are FDA-approved for treating osteoporosis. (medpagetoday.com)
- Those that were considered drug-related included flu-like symptoms (29% of zoledronic acid patients, 1% of the alendronate group) and gastrointestinal complaints (20% of alendronate patients, 7% of zoledronic acid patients). (medpagetoday.com)
- Only one out of 171 evaluable patients receiving teriparatide had radiographic evidence of a vertebral fracture, while 10 of 165 evaluable patients on alendronate had such fractures ( P =0.004). (medpagetoday.com)
- Twice as many patients on teriparatide as on alendronate did not complete the planned therapy because of adverse effects. (medpagetoday.com)
- Conclusion Alendronate sodium could cause lesions of the inferior esophageal portion or in distal segments of the gastrointestinal tube, in patients with a fast gastrointestinal transit. (scielo.br)
- DC clupea prolongation ALENDRONATE has an alert sent to doctors by drug studio Novartis, which says patients and people taking blood- thinners may not come back normal. (wanadoo.es)
- 40 patients (pt) with post-menopausal osteoporosis treated with alendronate (10 mg/d) for at least five years (Group 1, G1) had their medication discontinued. (scielo.br)
- Researchers used national Swedish registers from hospitals and ambulatory specialist care practices to identify 16,890 patients taking alendronate and matched them with 16,890 nonusers. (endocrinologyadvisor.com)
- 1 In addition, patients taking alendronate experienced 34% fewer hip fractures compared with nonusers, all of whom received concomitant glucocorticoid therapy. (endocrinologyadvisor.com)
- 1 However, similar results have been found in meta-analyses demonstrating the effect of alendronate in patients receiving glucocorticoids. (endocrinologyadvisor.com)
- 18% of patients used PPIs at baseline, and 27% used PPIs concurrently with alendronate during follow-up. (annals.org)
- New research has linked alendronate to reduced cardiovascular death in hip fracture patients. (the-rheumatologist.org)
- In a recent study , alendronate was linked to a reduced risk of cardiovascular death, myocardial infarction and stroke in hip fracture patients. (the-rheumatologist.org)
- We identified 283,586 alendronate patients and 40,463 raloxifene patients. (eur.nl)
19951
- So taking ALENDRONATE will organise your chance of a learning evaluation a Jefferson County ALENDRONATE had done of Frye in 1995, but that if you take steroids, you may have the gall inventor. (wanadoo.es)
Ingredient1
- It contains the active ingredient, alendronate (as alendronate sodium). (nps.org.au)
Fracture risk1
- Alendronate and raloxifene have a similar hip fracture risk (hazard ratio [HR] 1.03, 95% confidence interval [CI] 0.94-1.13), but alendronate users are more likely to have vertebral fractures (HR 1.07, 95% CI 1.01-1.14). (eur.nl)
Increases3
- Alendronate increases the thickness of bone ( bone mineral density ) by slowing down the cells that usually break down bone ( osteoclasts ). (medbroadcast.com)
- Alendronate reduces bone loss, increases bone density and reduces the risk of spine and non-spine fractures including hip fractures. (nof.org)
- Women who received alendronate had fewer increases in the spine deformity index (33% vs 41%, P = 0.03) and had a lower mean loss of height (3.0 vs 4.6 mm, P = 0.005). (acpjc.org)
Vitamin D32
- Alendronate with either 2,800 IU or 5,600 IU of vitamin D3 provides another option for a source of vitamin D. Weekly alendronate with 2,800 IU of vitamin D3 is the equivalent of taking 400 IU daily, while weekly alendronate with 5,600 IU of vitamin D3 is the equivalent of taking 800 IU daily. (nof.org)
- Online pharmacies in our program do not offer Alendronate sodium/Cholecalciferol (vitamin d3) 70 mg/5600iu for sale, but you can find the discounted U.S. price below. (pharmacychecker.com)
Trihydrate1
- Each white, oval, biconvex tablet engraved 'APO' on one side and 'ALE70' on the other contains 91.35 mg of alendronate sodium salt trihydrate, which is the molar equivalent of 70 mg of alendronate. (canada.com)
Absorption3
- In addition to alendronate, DRONALEN PLUS also contains vitamin D, an essential nutrient required for calcium absorption and healthy bones. (news-medical.net)
- Decreased alendronate absorption. (drugster.info)
- Absorption of alendronate is decreased by food. (drugster.info)
Zoledronic2
- She also said that, in and of themselves, the results weren't a reason to prefer zoledronic acid over alendronate. (medpagetoday.com)
- Unless I saw a head-to-head trial with a difference in fracture rates at that point in time, I wouldn't [pick zoledronic acid over alendronate]," Shane said. (medpagetoday.com)
Prevention3
- A team of Cochrane Researchers set out to evaluate the evidence behind the use of alendronate for primary and secondary prevention of bone fractures in these women. (innovations-report.com)
- For prevention, alendronate is taken daily as a 5 mg tablet or weekly as a 35 mg tablet. (nof.org)
- Raloxifene is as effective as alendronate and may remain an option in the prevention of osteoporotic fracture. (eur.nl)
Teriparatide3
- Teriparatide increased hip BMD by 3.8% while it rose 2.4% in the alendronate group. (medpagetoday.com)
- A 2006 study from Stanford University researchers found that teriparatide is less cost-effective than alendronate for postmenopausal women with severe osteoporosis. (medpagetoday.com)
- That finding assumed that teriparatide was 35% more effective than alendronate in reducing fractures -- about the same as in the new study. (medpagetoday.com)
Colecalciferol2
- It does not contain all the information that is known about alendronate and colecalciferol. (nps.org.au)
- It contains the active ingredients alendronate sodium and colecalciferol. (nps.org.au)
Osteoporosis-related fractures1
- By making bones stronger, alendronate can help to reduce the incidence of osteoporosis-related fractures. (medbroadcast.com)
Group8
- She noted that the biomarkers were "already highly suppressed" in the alendronate group at the six-week mark. (medpagetoday.com)
- in the group 2 (G2) was used subcutenous alendronate (0.5 mg/kg) once for three weeks and then was realizd the both surgical techniques. (scielo.cl)
- In group 3 (G3), after ovariectomy was realized the both dental extraction and the calvarium defect and after that was realized the alendronate protocol. (scielo.cl)
- Group 2 (G2): 25 pt treated with alendronate for at least one year. (scielo.br)
- BUA and Stiffness showed a significant increase in the alendronate-treated group at year 2 (3.2% and 4.9%, respectively) and at year 3 (3.8% and 6%, respectively). (nih.gov)
- To claim your free Alendronate Sodium discount, view the available manufacturer coupons or patient assistance programs below or use the free buying group coupon to get a discount on Alendronate Sodium today. (internetdrugcoupons.com)
- In the alendronate group (n = 3105), greater reductions in one or more biochemical marker were associated with a lower risk of fracture. (unboundmedicine.com)
- Forty-eight postmenopausal women were enrolled in a 1-year prospective randomized trial and assigned to alendronate monotherapy (5 mg/day) (group A, n = 26) or vitamin K(2) (45 mg/day) plus alendronate (5 mg/day) (group AK, n = 22). (druglib.com)
Droe nate1
- ALENDRONATE (a LEN droe nate) slows calcium loss from bones. (ahealthyme.com)
Prevent osteoporosis3
- Alendronate helps to treat and prevent osteoporosis only as long as it is taken regularly. (medlineplus.gov)
- Alendronate is used to treat or prevent osteoporosis or bone thinning in men and post-menopausal women and Paget's disease or bone deformity. (medindia.net)
- Alendronate and cholecalciferol is used to treat and prevent osteoporosis. (pardeehospital.org)
Cannot sit upright or stand2
- Do not take alendronate if you cannot sit upright or stand for at least 30 minutes after taking the medicine. (rexhealth.com)
- Alendronate Sodium should not be used by persons who cannot sit upright or stand for more than 30 minutes. (genericdoctor.com)
Decreases1
- Retrieved on November 29, 2020 from https://www.news-medical.net/news/20120919/Alendronate-decreases-BMD-loss-in-prostate-cancer.aspx. (news-medical.net)
Atrial Fibrillation1
- Alendronate use is associated with an increased risk for atrial fibrillation in women. (greenmedinfo.com)