Alendronate: A nonhormonal medication for the treatment of postmenopausal osteoporosis in women. This drug builds healthy bone, restoring some of the bone loss as a result of osteoporosis.Bone Density Conservation Agents: Agents that inhibit BONE RESORPTION and/or favor BONE MINERALIZATION and BONE REGENERATION. They are used to heal BONE FRACTURES and to treat METABOLIC BONE DISEASES such as OSTEOPOROSIS.Osteoporosis, Postmenopausal: Metabolic disorder associated with fractures of the femoral neck, vertebrae, and distal forearm. It occurs commonly in women within 15-20 years after menopause, and is caused by factors associated with menopause including estrogen deficiency.Etidronic Acid: A diphosphonate which affects calcium metabolism. It inhibits ectopic calcification and slows down bone resorption and bone turnover.Diphosphonates: Organic compounds which contain P-C-P bonds, where P stands for phosphonates or phosphonic acids. These compounds affect calcium metabolism. They inhibit ectopic calcification and slow down bone resorption and bone turnover. Technetium complexes of diphosphonates have been used successfully as bone scanning agents.Bone Density: The amount of mineral per square centimeter of BONE. This is the definition used in clinical practice. Actual bone density would be expressed in grams per milliliter. It is most frequently measured by X-RAY ABSORPTIOMETRY or TOMOGRAPHY, X RAY COMPUTED. Bone density is an important predictor for OSTEOPOROSIS.Osteoporosis: Reduction of bone mass without alteration in the composition of bone, leading to fractures. Primary osteoporosis can be of two major types: postmenopausal osteoporosis (OSTEOPOROSIS, POSTMENOPAUSAL) and age-related or senile osteoporosis.Bone Remodeling: The continuous turnover of BONE MATRIX and mineral that involves first an increase in BONE RESORPTION (osteoclastic activity) and later, reactive BONE FORMATION (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium HOMEOSTASIS. An imbalance in the regulation of bone remodeling's two contrasting events, bone resorption and bone formation, results in many of the metabolic bone diseases, such as OSTEOPOROSIS.Fractures, Bone: Breaks in bones.Teriparatide: A polypeptide that consists of the 1-34 amino-acid fragment of human PARATHYROID HORMONE, the biologically active N-terminal region. The acetate form is given by intravenous infusion in the differential diagnosis of HYPOPARATHYROIDISM and PSEUDOHYPOPARATHYROIDISM. (Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Englewood, CO, 1995)Femoral Fractures: Fractures of the femur.Bone Resorption: Bone loss due to osteoclastic activity.Femur: The longest and largest bone of the skeleton, it is situated between the hip and the knee.Spinal Fractures: Broken bones in the vertebral column.Bone and Bones: A specialized CONNECTIVE TISSUE that is the main constituent of the SKELETON. The principle cellular component of bone is comprised of OSTEOBLASTS; OSTEOCYTES; and OSTEOCLASTS, while FIBRILLAR COLLAGENS and hydroxyapatite crystals form the BONE MATRIX.Raloxifene: A second generation selective estrogen receptor modulator (SERM) used to prevent osteoporosis in postmenopausal women. It has estrogen agonist effects on bone and cholesterol metabolism but behaves as a complete estrogen antagonist on mammary gland and uterine tissue.Hydroxycholecalciferols: Hydroxy analogs of vitamin D 3; (CHOLECALCIFEROL); including CALCIFEDIOL; CALCITRIOL; and 24,25-DIHYDROXYVITAMIN D 3.Fractures, Spontaneous: Fractures occurring as a result of disease of a bone or from some undiscoverable cause, and not due to trauma. (Dorland, 27th ed)Collagen Type I: The most common form of fibrillar collagen. It is a major constituent of bone (BONE AND BONES) and SKIN and consists of a heterotrimer of two alpha1(I) and one alpha2(I) chains.Tibia: The second longest bone of the skeleton. It is located on the medial side of the lower leg, articulating with the FIBULA laterally, the TALUS distally, and the FEMUR proximally.Drugs, Generic: Drugs whose drug name is not protected by a trademark. They may be manufactured by several companies.Bone Diseases, MetabolicSpine: The spinal or vertebral column.Bone Demineralization Technique: Removal of mineral constituents or salts from bone or bone tissue. Demineralization is used as a method of studying bone strength and bone chemistry.Lumbar Vertebrae: VERTEBRAE in the region of the lower BACK below the THORACIC VERTEBRAE and above the SACRAL VERTEBRAE.Geranyltranstransferase: An enzyme involved in the MEVALONATE pathway, it catalyses the synthesis of farnesyl diphosphate from isopentenyl diphosphate and dimethylallyl diphosphate.Clodronic Acid: A diphosphonate which affects calcium metabolism. It inhibits bone resorption and soft tissue calcification.Intubation, Gastrointestinal: The insertion of a tube into the stomach, intestines, or other portion of the gastrointestinal tract to allow for the passage of food products, etc.Calcification, Physiologic: Process by which organic tissue becomes hardened by the physiologic deposit of calcium salts.Vitamin A: Retinol and derivatives of retinol that play an essential role in metabolic functioning of the retina, the growth of and differentiation of epithelial tissue, the growth of bone, reproduction, and the immune response. Dietary vitamin A is derived from a variety of CAROTENOIDS found in plants. It is enriched in the liver, egg yolks, and the fat component of dairy products.China: A country spanning from central Asia to the Pacific Ocean.Pharmacists: Those persons legally qualified by education and training to engage in the practice of pharmacy.Mineral Waters: Water naturally or artificially infused with mineral salts or gases.Dairy Products: Raw and processed or manufactured milk and milk-derived products. These are usually from cows (bovine) but are also from goats, sheep, reindeer, and water buffalo.Tablets: Solid dosage forms, of varying weight, size, and shape, which may be molded or compressed, and which contain a medicinal substance in pure or diluted form. (Dorland, 28th ed)Irritants: Drugs that act locally on cutaneous or mucosal surfaces to produce inflammation; those that cause redness due to hyperemia are rubefacients; those that raise blisters are vesicants and those that penetrate sebaceous glands and cause abscesses are pustulants; tear gases and mustard gases are also irritants.Beverages: Liquids that are suitable for drinking. (From Merriam Webster Collegiate Dictionary, 10th ed)Osteoporotic Fractures: Breaks in bones resulting from low bone mass and microarchitectural deterioration characteristic of OSTEOPOROSIS.Hip Fractures: Fractures of the FEMUR HEAD; the FEMUR NECK; (FEMORAL NECK FRACTURES); the trochanters; or the inter- or subtrochanteric region. Excludes fractures of the acetabulum and fractures of the femoral shaft below the subtrochanteric region (FEMORAL FRACTURES).Mixed Connective Tissue Disease: A syndrome with overlapping clinical features of systemic lupus erythematosus, scleroderma, polymyositis, and Raynaud's phenomenon. The disease is differentially characterized by high serum titers of antibodies to ribonuclease-sensitive extractable (saline soluble) nuclear antigen and a "speckled" epidermal nuclear staining pattern on direct immunofluorescence.Dermatomyositis: A subacute or chronic inflammatory disease of muscle and skin, marked by proximal muscle weakness and a characteristic skin rash. The illness occurs with approximately equal frequency in children and adults. The skin lesions usually take the form of a purplish rash (or less often an exfoliative dermatitis) involving the nose, cheeks, forehead, upper trunk, and arms. The disease is associated with a complement mediated intramuscular microangiopathy, leading to loss of capillaries, muscle ischemia, muscle-fiber necrosis, and perifascicular atrophy. The childhood form of this disease tends to evolve into a systemic vasculitis. Dermatomyositis may occur in association with malignant neoplasms. (From Adams et al., Principles of Neurology, 6th ed, pp1405-6)Connective Tissue Diseases: A heterogeneous group of disorders, some hereditary, others acquired, characterized by abnormal structure or function of one or more of the elements of connective tissue, i.e., collagen, elastin, or the mucopolysaccharides.Absorptiometry, Photon: A noninvasive method for assessing BODY COMPOSITION. It is based on the differential absorption of X-RAYS (or GAMMA RAYS) by different tissues such as bone, fat and other soft tissues. The source of (X-ray or gamma-ray) photon beam is generated either from radioisotopes such as GADOLINIUM 153, IODINE 125, or Americanium 241 which emit GAMMA RAYS in the appropriate range; or from an X-ray tube which produces X-RAYS in the desired range. It is primarily used for quantitating BONE MINERAL CONTENT, especially for the diagnosis of OSTEOPOROSIS, and also in measuring BONE MINERALIZATION.Cholecalciferol: Derivative of 7-dehydroxycholesterol formed by ULTRAVIOLET RAYS breaking of the C9-C10 bond. It differs from ERGOCALCIFEROL in having a single bond between C22 and C23 and lacking a methyl group at C24.Protective Devices: Devices designed to provide personal protection against injury to individuals exposed to hazards in industry, sports, aviation, or daily activities.Spasm: An involuntary contraction of a muscle or group of muscles. Spasms may involve SKELETAL MUSCLE or SMOOTH MUSCLE.Groin: The external junctural region between the lower part of the abdomen and the thigh.Thigh: The portion of the leg in humans and other animals found between the HIP and KNEE.Jaw: Bony structure of the mouth that holds the teeth. It consists of the MANDIBLE and the MAXILLA.Patient Handoff: The transferring of patient care responsibility from one health-care professional to another.Medication Reconciliation: The formal process of obtaining a complete and accurate list of each patient's current home medications including name, dosage, frequency, and route of administration, and comparing admission, transfer, and/or discharge medication orders to that list. The reconciliation is done to avoid medication errors.Drug Information Services: Services providing pharmaceutic and therapeutic drug information and consultation.Australia: The smallest continent and an independent country, comprising six states and two territories. Its capital is Canberra.
Alendronate gastric ulcers. (1/413)BACKGROUND: It appears likely that drugs other than NSAIDs may cause ulcers and ulcer complications (e.g. potassium chloride). Alendronate (Fosamax) is used in the treatment and prevention of metabolic bone disease and has also been associated with severe oesophageal damage and stricture. We have previously shown that the dose of alendronate used for Paget's disease (40 mg) causes gastric damage similar to NSAIDs. The usual dose for the treatment of postmenopausal osteoporosis is 10 mg per day. AIM: To investigate whether the 10 mg dose of alendronate causes gastric ulcers. METHODS: We performed an endoscopist-blind, crossover, randomized, single-centre comparison of 10 mg of alendronate/day and placebo in volunteers aged 40 years or more. Video-endoscopy was used to evaluate the presence and degree of mucosal damage to the oesophagus, stomach, or duodenal bulb after 7 and 14 days of treatment. RESULTS: Twenty-four healthy volunteers participated, including 15 women and nine men, ranging in age from 41 to 52 years. Visible gastric mucosal damage was present in nine (38%) who received alendronate compared to three (13%) in the placebo group. There was a marked difference in the severity of mucosal damage; there were no ulcers or large erosions in those receiving placebo. In contrast, potentially clinically significant gastric mucosal injury was seen in six subjects receiving alendronate (two developed antral ulcers and four had large (4-8 mm) superficial antral erosions) compared to none in the placebo group (P = 0.0219). One subject developed oesophageal damage in the form of multiple linear superficial erosions in the mid and distal oesophagus. Duodenal injury was not seen. CONCLUSION: Alendronate causes gastric ulceration, suggesting that alendronate use may be associated with ulcer complications such as acute upper gastrointestinal bleeding. The results of this study suggest the need for post-marketing surveillance to clarify the nature, frequency and magnitude of any potential gastrointestinal side-effects associated with the use of this drug. (+info)
Clinic visits and hospital admissions for care of acid-related upper gastrointestinal disorders in women using alendronate for osteoporosis. (2/413)CONTEXT: About 1 in 3 women taking alendronate for osteoporosis report gastrointestinal symptoms, a rate much higher than that found during clinical trials. OBJECTIVE: To establish the frequency of outpatient visits and hospital admissions for acid-related upper gastrointestinal disorder (ARD) among women taking alendronate and to identify potential risk factors. METHODS: A retrospective database analysis identified 812 women with osteoporosis who had filled one or more 10-mg alendronate prescriptions from October 1995 through October 1996. RESULTS: One hundred (12.3%) of the 812 women received healthcare for ARD, a clinical encounter rate of 28.5 per 100 person-years. A reference group of 362,109 women from the same health plan had 17.6 ARD encounters per 100 person-years. Excluding women who had ARDs before receiving alendronate, alendronate users were 1.6 (95% CI = 1.2, 2.7) times more likely to have an ARD encounter than nonusers. Risk of having ARD increased with age [users aged 70 years and older had a relative risk of 1.5 (95% confidence interval (CI) 1.0-2.30) compared with younger women] and with concurrent use of nonsteroidal anti-inflammatory drugs (NSAIDS) (relative risk 1.7, 95% CI 1.1-2.6). CONCLUSIONS: Elderly alendronate users or those concurrently taking NSAIDS should be carefully monitored because of their high risk of having ARD. Cost/benefit analyses of alendronate treatment for osteoporosis should include costs of treating ARD. (+info)
Alendronate induces antinociception in mice, not related with its effects in bone. (3/413)The antinociceptive effect of alendronate was studied. The bisphosphonate was i.p. administered and two tests were carried out: acetic acid in mice and formalin test in rats. In the acetic acid test, alendronate induced a dose-dependent antinociceptive effect that was statistically significant for the doses of 10, 20 and 40 mg/kg, and could be detected 48 hr after its administration. In the formalin test, however, alendronate, at the doses of 10 and 20 mg/kg, did not modify the pain score nor the number of flinches, when it was administered either 30 or 60 min before the test. However it must be noted that doses inducing analgesic effect are close to those inducing toxicity. (+info)
Larger increases in bone mineral density during alendronate therapy are associated with a lower risk of new vertebral fractures in women with postmenopausal osteoporosis. Fracture Intervention Trial Research Group. (4/413)OBJECTIVE: To investigate whether the incidence of vertebral fractures is related to the magnitude of change in bone mineral density (BMD) during alendronate treatment. METHODS: Women in this study were age 55-81 years (n = 2,984). While participating in the Fracture Intervention Trial, they received 5 mg/day of alendronate for 2 years followed by 10 mg/day for the remaining 12-30 months of the study. Their BMD was measured at baseline and at 12 and 24 months, and spine radiographs were obtained at baseline and again at 36 or 48 months to identify new vertebral fractures. RESULTS: After 12 months of alendronate treatment, 35% of participants had increases of > or =3% in total hip BMD, and 21% had either decreased total hip BMD or no change. Women who had larger increases in total hip BMD during the first 12 months had a lower incidence of new vertebral fractures during the entire followup period. Only 3.2% of women with increases of > or =3% in total hip BMD experienced new vertebral fractures, whereas twice as many women (6.3%) whose BMD declined or stayed the same experienced new fractures (adjusted odds ratio 0.45, 95% confidence interval 0.27-0.72). Similar patterns were observed for spine BMD at 12 months, and for both sites using change in BMD at 24 months. CONCLUSION: Women with increases of > or =3% in BMD during the first 1 or 2 years of alendronate treatment had the lowest incidence of new vertebral fractures. These findings suggest that, among women taking antiresorptive agents, greater increases in BMD are associated with lower risk of new vertebral fractures. (+info)
Farnesol and geranylgeraniol prevent activation of caspases by aminobisphosphonates: biochemical evidence for two distinct pharmacological classes of bisphosphonate drugs. (5/413)Recently, advances have been made in understanding the molecular mechanisms by which bisphosphonate drugs inhibit bone resorption. Studies with the macrophage-like cell line J774 have suggested that alendronate, an amino-containing bisphosphonate, causes apoptosis by preventing post-translational modification of GTP-binding proteins with isoprenoid lipids. However, clodronate, a nonaminobisphosphonate, does not inhibit protein isoprenylation but can be metabolized intracellularly to a cytotoxic, beta-gamma-methylene (AppCp-type) analog of ATP. These observations raise the possibility that bisphosphonates can be divided into two groups with distinct molecular mechanisms of action depending on the nature of the R2 side chain. We addressed this question by directly comparing the ability of three aminobisphosphonates (alendronate, ibandronate, and pamidronate) and three nonaminobisphosphonates (clodronate, etidronate, and tiludronate) to inhibit protein isoprenylation and activate caspase-3-like proteases or to be metabolized to AppCp-type nucleotides by J774 cells. All three aminobisphosphonates inhibited protein isoprenylation and activated caspase-3-like proteases. Apoptosis and caspase activation after 24-h treatment with the aminobisphosphonates could be prevented by addition of farnesol or geranylgeraniol, confirming that these bisphosphonates inhibit the metabolic mevalonate pathway. No AppCp-type metabolites of the aminobisphosphonates could be detected by mass spectrometry. The three nonaminobisphosphonates did not inhibit protein isoprenylation or cause activation of caspase-3-like proteases, but were incorporated into AppCp-type nucleotides. Taken together, these observations clearly demonstrate that bisphosphonate drugs can be divided into two pharmacological classes: the aminobisphosphonates, which act by inhibiting protein isoprenylation, and the less potent nonaminobisphosphonates, which act through the intracellular accumulation of AppCp-type metabolites. (+info)
Use of bone alkaline phosphatase to monitor alendronate therapy in individual postmenopausal osteoporotic women. (6/413)BACKGROUND: Biochemical bone markers are sensitive to the changes in bone turnover that result from treatment of postmenopausal osteoporotic women with antiresorptive therapies. Although information is available on the use of bone markers in monitoring therapy in groups of subjects, less is known regarding how these markers perform in individual patients. METHODS: Serum bone alkaline phosphatase (bone ALP) concentrations, measured with the Tandem(R) Ostase(R) assay, were used to monitor the biochemical response of bone in postmenopausal women with osteoporosis receiving either 10 mg/day alendronate therapy (n = 74) or calcium supplementation (n = 148) for 24 months. RESULTS: Bone ALP decreased significantly from baseline at 3 months (P +info)
Prevention of osteoporosis and fractures. (7/413)Osteoporosis and low bone density are associated with a risk of fracture as a result of even minimally traumatic events. The estimated lifetime risk of osteoporotic fracture is as high as 50 percent, especially in white and Asian women. The use of caffeine, tobacco and steroids is associated with a decrease in bone density. Cognitive impairment, vision problems and postural instability increase the risk of falling and sustaining a fracture. Medications such as long-acting sedative hypnotics, anticonvulsants and tricyclic antidepressants also increase this risk. Combinations of clinical and radiographic findings can predict fracture risk more effectively than bone densitometry, but often only after the first fracture has occurred. The addition of dietary calcium and/or vitamin D is clearly both cost-effective and significant in reducing the likelihood of fractures. Bisphosphonates reduce fracture risk but at a cost that may be prohibitive for some patients. Estrogen and estrogen-receptor modulators have not been well studied in randomized trials evaluating the reduction of fractures, but they are known to increase bone density. Pharmacologic therapy and the reduction of sensory and environmental hazards can prevent osteoporotic fractures in some patients. (+info)
Prevention of osteocyte and osteoblast apoptosis by bisphosphonates and calcitonin. (8/413)Glucocorticoid-induced osteoporosis may be due, in part, to increased apoptosis of osteocytes and osteoblasts, and bisphosphonates (BPs) are effective in the management of this condition. We have tested the hypothesis that BPs suppress apoptosis in these cell types. Etidronate, alendronate, pamidronate, olpadronate, or amino-olpadronate (IG9402, a bisphosphonate that lacks antiresorptive activity) at 10(-9) to 10(-6) M prevented apoptosis of murine osteocytic MLO-Y4 cells, whether it was induced by etoposide, TNF-alpha, or the synthetic glucocorticoid dexamethasone. BPs also inhibited apoptosis of primary murine osteoblastic cells isolated from calvaria. Similar antiapoptotic effects on MLO-Y4 and osteoblastic cells were seen with nanomolar concentrations of the peptide hormone calcitonin. The antiapoptotic effect of BPs and calcitonin was associated with a rapid increase in the phosphorylated fraction of extracellular signal regulated kinases (ERKs) and was blocked by specific inhibitors of ERK activation. Consistent with these in vitro results, alendronate abolished the increased prevalence of apoptosis in vertebral cancellous bone osteocytes and osteoblasts that follows prednisolone administration to mice. These results suggest that the therapeutic efficacy of BPs or calcitonin in diseases such as glucocorticoid-induced osteoporosis may be due, in part, to their ability to prevent osteocyte and osteoblast apoptosis. (+info)
Keep alendronate sodium tablets and all medicines out of the reach of children. General information about the safe and effective use of alendronate sodium tablets . Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide. Do not use alendronate sodium tablets for a condition for which it was not prescribed. Do not give alendronate sodium tablets to other people, even if they have the same symptoms you have. It may harm them. This Medication Guide summarizes the most important information about alendronate sodium tablets. If you would like more information, talk with your doctor. You can ask your doctor or pharmacist for information about alendronate sodium tablets that is written for health professionals. For more information, call 1-800-272-5525. What are the ingredients in alendronate sodium tablets ? ...
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CAS# 121268-17-5 Description of Alendronate sodium: Alendronate sodium is the sodium salt of alendronate, a second generation bisphosphonate and synthetic analog of pyrophosphate with bone anti-resorption activity. Alendronate sodium binds to and inhibits the activity of geranyltranstransferase (farnesyl pyrophosphate synthetase), an enzyme involved in terpenoid biosynthesis. Inhibition of this enzyme prevents the biosynthesis of isoprenoid lipids (FPP and GGPP) that are donor substrates of farnesylation and geranylgeranylation during the post-translational modification of small GTPase signalling proteins, which is important in the process of osteoclast turnover. As a result, osteoclast activity is inhibited and bone resorption and turnover are reduced.
The Effect of Alendronate on Fracture-Related Healthcare Utilization and Costs: The Fracture Intervention Trial. Chrischilles, E. A.; Dasbach, E. J.; Rubenstein, L. M.; Cook, J. R.; Tabor, H. K.; Black, D. M. // Osteoporosis International;Sep2001, Vol. 12 Issue 8, p654 The Vertebral Fracture Arm (VFA) of the Fracture Intervention Trial (FIT) study demonstrated that alendronate reduced the incidence of spine, forearm and hip fractures in women with low bone mass and existing vertebral fractures by about 50%. The objective of the present study was to determine... ...
TY - JOUR. T1 - T-Score as an Indicator of Fracture Risk During Treatment With Romosozumab or Alendronate in the ARCH Trial. AU - Cosman, Felicia. AU - Lewiecki, E. Michael. AU - Ebeling, Peter R.. AU - Hesse, Eric. AU - Napoli, Nicola. AU - Matsumoto, Toshio. AU - Crittenden, Daria B.. AU - Rojeski, Maria. AU - Yang, Wenjing. AU - Libanati, Cesar. AU - Ferrari, Serge. PY - 2020/7/1. Y1 - 2020/7/1. N2 - In the Active-Controlled Fracture Study in Postmenopausal Women With Osteoporosis at High Risk (ARCH) clinical trial (NCT01631214), 1 year of romosozumab followed by alendronate reduced the risk of vertebral and nonvertebral fractures compared to alendronate alone in women with prevalent fracture. We performed post hoc analyses of data from patients in ARCH (romosozumab, n = 1739; alendronate, n = 1726) who had a baseline BMD measurement and received at least one open-label alendronate dose. We evaluated 1-year mean BMD and corresponding T-score changes; proportions of patients achieving T-scores ...
UNLABELLED Once-weekly alendronate 70 mg and once-weekly risedronate 35 mg are indicated for the treatment of postmenopausal osteoporosis. These two agents were compared in a 12-month head-to-head trial. Greater gains in BMD and greater reductions in markers of bone turnover were seen with alendronate compared with risedronate with similar tolerability. INTRODUCTION The nitrogen-containing bisphosphonates, alendronate and risedronate, are available in once-weekly (OW) formulations for the treatment of postmenopausal osteoporosis. A 12-month, head-to-head study was performed to compare these agents in the treatment of postmenopausal women with low BMD. MATERIALS AND METHODS A total of 1053 patients from 78 U.S. sites were randomized to OW alendronate 70 mg (N = 520) or risedronate 35 mg (N = 533), taken in the morning after fasting. Endpoints included BMD changes over 6 and 12 months at the hip trochanter, total hip, femoral neck, and lumbar spine (LS); percent of patients with predefined levels of
Aurobindo Pharma Ltd has received the final approval from the US Food & Drug Administration (US FDA) to manufacture and market alendronate sodium tablets USP 10mg, 35mg and 70mg. According to the company, it is a Paragraph IV certification. Alendronate sodium tablets are the generic equivalent of Merck & Co Incs Fosamax tablets USP 10mg, 35mg and 70mg, which are indicated for the treatment of osteoporosis (bone disease). Annual sales of alendronate sodium tablets USP 10mg, 35mg and 70mg in the US were approximately US$ 1,982 million for the twelve months ending December 2007 according to Mercks financial disclosures.. Aurobindo is in the first line of generics and got the US FDA nod on the very first day post the expiry of the relevant patent and the product will be launched immediately in the US market. This has been one of fastest approvals received by the company, within 8 months of the date of filing. It is Aurobindos 73rd ANDA approval from the US FDA.. ...
Alendronate sodium hydrate (oral jelly) for the treatment of osteoporosis: review of a novel, easy to swallow formulation Kazuhiro Imai Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Tokyo, Japan Abstract: Osteoporosis is a skeletal disorder characterized by loss of bone mass, decreased bone strength, and an increased risk of bone fracture. The disease progresses with age, especially in postmenopausal women. Japan is one of the most rapidly aging societies worldwide. Japanese individuals over 65 years of age constituted 23.0% of the population in 2010 and 25.1% to 25.2% as of 2013. The estimated number of people with osteoporosis in Japan is currently 13 million. Bisphosphonates increase bone mineral density by inhibiting osteoclast-mediated bone resorption, thereby reducing the risk of fractures. Alendronate sodium hydrate (alendronate) is a bisphosphonate that potently inhibits bone resorption and is used to treat osteoporosis. Sufficient water is required
If you are using alendronate oral liquid, drink at least 2 ounces (a quarter of a cup) of water immediately after taking the medicine. This will allow the medicine to reach your intestines and be absorbed by the body more quickly. Swallow the tablet whole with a full glass (6 to 8 ounces) of plain water. Do not suck or chew on the tablet because it may cause throat irritation. If you are taking alendronate effervescent tablet, dissolve it in 4 ounces of room temperature plain water only (not mineral water or flavored water). Wait at least 5 minutes after the effervescence stops and then stir the solution for 10 seconds and drink it. Do not lie down for at least 30 minutes after taking alendronate and before having your first food for the day. This will help alendronate reach your stomach faster. It will also help prevent irritation to your esophagus. It is important that you eat a well-balanced diet with adequate amounts of calcium and vitamin D (found in milk or other dairy products). However, ...
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Decreased bone mineral density (BMD) has been identified in up to 50% of HIV infected men, with severe osteoporosis in up to 21% of these men. The mechanisms underlying these bone abnormalities remain unclear. Bisphosphonates are potent bone resorption inhibitors and have been shown to be effective in treating osteoporosis. While several bisphosphonates are approved for the treatment of osteoporosis in women, alendronate is the only bisphosphonate approved for treatment in men. This study hypothesizes that alendronate will be able to reverse decreased BMD secondary to inhibition of bone resorption in HIV infected patients treated with potent antiretroviral therapy, and that these patients will be able to tolerate alendronate without any significant toxicities. The study will also examine the efficacy of once-weekly alendronate with daily calcium and vitamin D in both men and women with HIV.. Patients will participate in this study for 48 weeks. Patients will be randomly assigned to receive ...
Main / Thermometers / Alendronate oral dosage Usual Adult Dose for Osteoporosis. Treatment of Osteoporosis in Postmenopausal Women; To Increase Bone Mass in Men with Osteoporosis: 10 mg orally once a day or mg orally once a week. Treatment of Glucocorticoid-Induced Osteoporosis: 5 mg orally once a day or mg orally once a day in postmenopausal. Administration. Take only in morning, not at bedtime or before arising. Take tablet with full glass of water ( oz) at least 30 minutes before first food or drink of day, in upright position. Administer oral solution with at least 2 ounces of water. Swallow with plain water only; mineral water, coffee, juice or other beverages.. Alendronate (Fosamax, Binosto) is an oral drug used together to treat and prevent blood. Learn about side effects, warnings, dosage, and more.Side effects · Interactions · Other warnings · Dosage. System AND ADMINISTRATION. Suppose alendronate tablets 5 mg, 10 mg, 35 mg, and 40 mg are alendronate oral dosage in the ...
Importance Oral glucocorticoid treatment increases fracture risk, and evidence is lacking regarding the efficacy of alendronate to protect against hip fracture in older patients using glucocorticoids.Objective To investigate whether alendronate treatment in older patients using oral prednisolone is associated with decreased hip fracture risk and adverse effects.Design, Setting, and Participants Retrospective cohort study using a national database (N = 433 195) of patients aged 65 years or older undergoing a health evaluation (baseline) at Swedish health care facilities; 1802 patients who were prescribed alendronate after at least 3 months of oral prednisolone treatment (≥5 mg/d) were identified. Propensity score matching was used to select 1802 patients without alendronate use from 6076 patients taking prednisolone with the same dose and treatment time criteria. Follow-up occurred between January 2008 and December 2014.Exposures Alendronate vs no alendronate use; no patients had previously ...
Main results. 18% of patients used PPIs at baseline, and 27% used PPIs concurrently with alendronate during follow-up. 5.4% of patients had hip fractures, 1.5% had forearm fractures, 0.9% had humerus fractures, and 0.6% had spine fractures. Concurrent use of PPIs was associated with reduced effectiveness of alendronate for preventing hip fractures compared with no PPI use (Table); PPI use did not attenuate the effectiveness of alendronate for preventing forearm (4.5/1000 patient-y in PPI users vs 4.3/1000 patient-y in nonusers), humerus (2.9 vs 2.5/1000 patient-y), or spine (2.7 vs 1.3/1000 patient-y) fractures. In patients who used PPIs concurrently with alendronate, reduction in risk for hip fractures attenuated in a dose-dependent manner and was maintained only at lower cumulative PPI doses (cumulative defined daily doses [DDDs] 1 to 359, n = 7210, hazard ratio [HR] 0.63, 95% CI 0.55 to 0.72; DDDs 360 to 719, n = 1701, HR 1.00, CI 0.70 to 1.45; DDDs ≥ 720, n = 1266, HR 1.24, CI 0.71 to ...
Atypical femur fracture: There is evidence that long term use of this class of medication may contribute to a type of rare fracture of the long bone in the thigh (femur).. If you experience new or unusual pain in the groin, hip, or thigh area, contact your doctor as soon as possible.. Bone, joint, and muscle problems: Rarely, people taking this medication experience severe bone, joint, or muscle pain. This is usually reversed when the medication is stopped.. Calcium and vitamin D: Calcium and vitamin D are important contributors to bone growth and strength. It may be necessary to take calcium or vitamin D supplements to get the best effect from alendronate if you are not getting enough from your diet. Your doctor may test you for low calcium levels or vitamin D deficiency before you start taking alendronate.. Effects on the esophagus: Alendronate may irritate the lining of the esophagus (the passage from the throat to the stomach). Esophagitis, ulcers, and erosions have been reported by people ...
TY - JOUR. T1 - Randomized controlled trial of alendronate in airways disease and low bone mineral density. AU - Smith, B. J.. AU - Laslett, L. L.. AU - Pile, K. D.. AU - Phillips, P. J.. AU - Phillipov, G.. AU - Evans, S. M.. AU - Esterman, A. J.. AU - Berry, J. G.. PY - 2004/1/1. Y1 - 2004/1/1. N2 - Background:Patients with airways disease have been demonstrated to be at risk of osteoporosis, and this is likely to be multifactorial. Our aim was to identify patients with low bone mineral density (BMD) using a screening program, and then evaluate the benefit of daily alendronate. Method:Subjects with hip or lumbar spine baseline T-scores ,-2.5, or Z-score ,-1.0 commenced on alendronate/calcium (10 mg/600 mg day) or placebo/calcium, in a double blind randomized controlled trial. BMD by dual emission X-ray absorptiometry (lumbar vertebrae 2-4, neck of femur, total femur) was repeated after 12 months, with adverse events recorded. Results: 145 subjects (74 male, 71 female, mean age 67, median FEV, ...
Member of Farmavita.net is offering dossier in European CTD format for Alendronate sodium; 5/10/35/70 mg, tablets.. Dossier is registered in EU RMS.. License for the use of the Dossier is related to initial downpayment and commitment to bulk purchase of blisters. Alendronate sodium is classified as a medicine for osteoporosis, according to the ATC index. Offer is valid subject to confirmation, country by country. There will be no sales in those countries where this offer would constitute an infringement of third parties intellectual proprietary rights. Farmavita.Net is not owner of offered products/licenses and do not take any liability related to them. However, as the licensing agent we do our the best to facilitate that closed licensing agreements are made on mutual benefit of contracting parties and without infringement of intellectual property of third parties. ...
Alendronate Sodium Hainan is a medicine available in a number of countries worldwide. A list of US medications equivalent to Alendronate Sodium Hainan is available on the Drugs.com website.
Sandoz Alendronate: Alendronate belongs to a family of medications known as bisphosphonates. It is used to treat and prevent osteoporosis for postmenopausal women. It is also used to treat osteoporosis for men.
Effects of short-term combined treatment with alendronate and elcatonin on bone mineral density and bone turnover in postmenopausal women with osteoporosis Jun Iwamoto1, Mitsuyoshi Uzawa2, Yoshihiro Sato3, Tsuyoshi Takeda1, Hideo Matsumoto11Institute for Integrated Sports Medicine, Keio University School of Medicine, Tokyo, Japan; 2Department of Orthopaedic Surgery, Keiyu Orthopaedic Hospital, Gunma, Japan; 3Department of Neurology, Mitate Hospital, Fukuoka, Japan Abstract: The antiresorptive drug elcatonin (ECT) is known to relieve pain in postmenopausal women with osteoporosis. A prospective open-labeled trial was conducted to compare the effects of short-term combined treatment with alendronate (ALN) and ECT on bone mineral density (BMD) and bone turnover with those of single treatment with ALN in postmenopausal women with osteoporosis. Two hundred and five postmenopausal osteoporotic women (mean age: 70 years) were recruited in our outpatient clinic. Forty-six women with back pain were treated
In this Danish national register-based cohort study, we examined the effects of alendronate on the development of colon cancers and survival. The incidence of colon cancer and mortality rate, once colon cancer had been diagnosed, were lower in patients treated with alendronate, posing the question whether alendronate acts as chemopreventive.When bisphosphonates are given by mouth, around 99% remains non-absorbed in the intestine. Based on their biochemical actions, we predicted that oral bisphosphonates might prevent colon cancers.This is a Danish national register-based cohort study. We identified 30,606 women aged 50+, mean age 71.9 years, who had not previously taken treatments for osteoporosis, who began to take alendronate in 1996-2005, and assigned 124,424 individually age- and gender-matched control subjects. The main outcome measure was colorectal cancers incidence and post-diagnosis survival in patients taking oral alendronate for osteoporosis.Cox proportional hazards analysis of death due to
Context.-Alendronate sodium reduces fracture risk in postmenopausal women who have vertebral fractures, but its effects on fracture risk have not been studied
Total 801 participants randomized. Of the randomized patients, 263 who received at least one dose of ibandronate as an injection, 263 who received at least one dose of ibandronate as an infusion and 267 patients who received at least one dose of alendronate had at least one post-baseline assessment and were included in the safety analysis ...
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Alendronate is a bisphosphonate which prevent the osteoclast mediated bone resorption. Alendronate may decrease bone resorption and increase the density of the bone.
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Patient Information FOSAMAX PLUS D (FOSS-ah-max PLUS D) (alendronate sodium/cholecalciferol) Tablets Read the patient information before you start taking FOSAMAX PLUS D 1. Also, read the leaflet each time
Cheap alendronate - no rx over the internet. Alendronate is used in the treatment and prevention of osteoporosis in postmenopausal women; the drug also is used to increase bone mass in men with osteoporosis
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Bisphosphonates are currently the preferred treatment for CS osteoporosis and evidence comes from several recent trials. Most of these studies have examined their efficacy on BMD as the primary end point, although post hoc analyses consistently support an effect on fractures in the subgroup at highest risk-namely, postmenopausal women. The earliest trial to demonstrate efficacy used oral pamidronate, but studies now exist with all the commonly used bisphosphonates, including etidronate, alendronate, risedronate, and intravenous pamidronate.. The largest studies to date have been with oral alendronate and risedronate. The alendronate studies examined doses of 5 mg and 10 mg daily compared with a control group receiving prophylaxis with calcium/vitamin D and largely pooling the prevention and treatment arms. Over 12 months of follow up, the mean change in lumbar spine BMD in patients receiving CS for less than 4 months was +3.0% for alendronate 10 mg/day compared with -1% in the control group. In ...
DENVER -- Biochemical markers of bone turnover showed significantly faster responses on initiation of once-yearly zoledronic acid (Reclast) infusion than with weekly oral alendronate (Fosamax).
It is important that you tell all of your health care providers that you are taking alendronate and cholecalciferol combination. If you are having a dental procedure while taking this medicine, you may have an increased chance of having a severe problem with your jaw. Make sure you tell your doctor about any new medical problems, especially with your teeth or jaws. Tell your doctor if you have severe bone, joint, or muscle pain while using this medicine. This medicine could lower the amount of calcium in your blood. Call your doctor right away if you develop any signs of low calcium levels, such as muscle spasms or twitching, or numbness or tingling in your fingers, toes, or lips. This medicine may increase your risk of developing fractures of the thigh bone. This may be more common if you use it for a long time. Check with your doctor right away if you have a dull or aching pain in the thighs, groin, or hips. Do not take other medicines unless they have been discussed with your doctor. This ...
Fibrous encapsulation can impair implant osseointegration and cause implant failure but currently there are limited strategies to address this problem. Since bisphosphonates (BPs), a class of drugs widely used to treat bone diseases, was recently found to induce fibroblast apoptosis, we hypothesize that by loading BPs on titanium (Ti) implant surface, fibrous encapsulation may be inhibited with simultaneous enhancement of implant osseointegration. This strategy of local administration can also be expected to minimize the adverse side effects of BPs, which are associated with intravenous injections. To verify this hypothesis, alendronate was loaded on Ti surface via a hydroxyapatite (CaP) coating, and the effects of the loaded alendronate on fibroblast proliferation and apoptosis, and osteoblast proliferation, alkaline phosphatase (ALP) activity, and apoptosis were investigated in vitro. With a surface density of loaded alendronate 0.046 mg/cm2 or higher, fibroblast proliferation was suppressed ...
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While Vγ9Vδ2 T cells have been shown to be effective as a cancer immunotherapy , especially when used in combination with N-BPs [5-15], little is known about the in vivo behaviour of human γδ T cells in murine models. This is important to find out if a correlation between the number of γδ T cells in tumour mass and the success of the therapy can be established. While the use of human γδ T cells in cancer therapy is well established, yet questions remain concerning mechanisms involved in recruiting these cells to specific tumours in different tissues. This is an important issue since localisation to the tumour mass is thought to be required for efficacy. Previous studies where human γδ T cells were adoptively transferred in different tumour models established in mice mostly used qualitative, histological approaches to address tumour accumulation [7, 10]. In this work a highly quantitative and unbiased approach is used to measure human γδ T cell accumulation in tumours grown in ...
School of Medicine. "By sharing the detailed results of efficacy and safety, we aim to help clinicians understand the future benefit:risk profile of romosozumab and its potential as a treatment option for postmenopausal women living with osteoporosis.". At primary analysis, postmenopausal women in the EVENITY treatment group experienced a statistically significant 19.0 percent relative reduction in the risk of non-vertebral fractures (8.7 percent versus 10.6 percent, respectively [p=0.04]). A 38.0 percent relative reduction in the risk of hip fractures was also observed (2.0 percent versus 3.2 percent, respectively [nominalp=0.015]), when compared to those receiving alendronate alone. Postmenopausal women who received EVENITY achieved greater gains in bone mineral density (BMD) from baseline at all measured sites and at all time points of the study versus those receiving alendronate alone. At month 12, the percentage change from baseline was greater with EVENITY versus alendronate at the lumbar ...
High-dose corticosteroids, used for many medical conditions, are associated with rapid bone loss from sites such as the vertebrae, and compression fractures can be observed within months. Recent trials suggest treatment with bisphosphonates or active vitamin D analogs can reduce bone loss and the risk of fracture associated with glucocorticoids, but few studies have directly compared such agents. We conducted a randomized, multicenter, open-label trial to compare the efficacy of alendronate, calcitriol, and simple vitamin D in prevention and treatment of glucocorticoid-induced bone loss. A total of 195 subjects (134 females and 61 males) commencing or already taking glucocorticoids were randomized to one of three groups: calcitriol, 0.5 to 0.75 microg/day; simple vitamin D (ergocalciferol, 30,000 IU weekly) plus calcium carbonate (600 mg daily); or alendronate, 10 mg/day plus calcium carbonate (600 mg daily). Over 2 years, mean lumbar bone mineral density change was +5.9% with alendronate, -0.5% with
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Alendronic acid (INN) or alendronate sodium - sold as Fosamax by Merck - is a bisphosphonate drug used for osteoporosis, osteogenesis imperfecta, and several other bone diseases. It is marketed alone as well as in combination with vitamin D (2,800 IU and 5,600 IU, under the name Fosamax+D). Mercks U.S. patent on alendronate expired in 2008 and the drug is now available as a generic. It is the most widely prescribed bisphosphonate medicine in the United States . As with all potent bisphosphonates, the fraction of the drug that reaches the circulatory system intact (systemic bioavailability) after oral dosing is low, averaging only 0.6-0.7% in women and in men under fasting conditions. Intake together with meals and beverages other than water further reduces the bioavailability. The absorbed drug rapidly partitions, with approximately 50% binding to the exposed bone surface; the remainder is excreted unchanged by the kidneys. Unlike with most drugs, the strong negative charge on the two ...
Purpose: Combined treatment with alendronate and alfacalcidol is more beneficial to increase bone mineral density (BMD) than alendronate or alfacalcidol alone. decreased (?42.5% at 3 months and ?18.9% at 3 years) and the lumbar spine BMD but not the total hip BMD significantly increased (14.8% at 3 years) compared with the baseline values. However the incidence of vertebral and nonvertebral fractures was 26.5% and 2.9% respectively suggesting a high incidence of vertebral fractures. Conclusion: The outcomes of todays research suggest that mixed treatment with alendronate and alfacalcidol could be useful to decrease bone tissue turnover and raise the lumbar backbone BMD in individuals with severe bone tissue reduction and osteoporotic fracture. Its effectiveness MK-0752 against vertebral fractures appears never to end up being sufficient However. Thus anabolic real estate agents such as for example teriparatide ought to be taken into account as Edg3 first-line medicines in individuals with ...
Fosamax (Alendronate) drug is used to treat or prevent osteoporosis in women after menopause, can help to reduce the chance of having a spinal or hip fracture.
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Read the side effects of Alendronate as described in the medical literature. In case of any doubt consult your doctor or pharmacist.
After absorption in the bone, alendronate has an estimated terminal elimination half-life of 10 years. Alendronate inhibits ... the absorption of alendronate is decreased. At least half an hour should pass after intake of alendronate before taking the ... Bone: alendronate has been linked in long-term users to the development of low-impact femoral fractures. Further, studies ... Alendronate". Bioorg. Med. Chem. 4 (1): 3-4. doi:10.1016/0968-0896(96)00042-9. PMID 8689235. Black DM, Cummings SR, Karpf DB, ...
The bisphosphonate alendronate reduces the risk of hip, vertebral, and wrist fractures by 35-39%; zoledronate reduces the risk ... Heckbert SR, Li G, Cummings SR, Smith NL, Psaty BM (April 2008). "Use of alendronate and risk of incident atrial fibrillation ... Only in the 1990s was their actual mechanism of action demonstrated with the initial launch of Fosamax (alendronate) by Merck ... Wysowski D, Chang J (2005). "Alendronate and risedronate: reports of severe bone, joint, and muscle pain". Arch Intern Med. 165 ...
... is a class of prescription drugs in India appearing as an appendix to the Drugs and Cosmetics Rules, 1945 introduced in 1945. These are drugs which cannot be purchased over the counter without the prescription of a qualified doctor.The manufacture and sale of all drugs are covered under the Drugs and Cosmetics Act and Rules. It is revised at times based on the advice of the Drugs Technical Advisory Board, part of the Central Drugs Standard Control Organization in the Ministry of Health and Family Welfare. The most recent schedule H (2006) lists 536 drugs from abacavir to zuclopenthixol. However, enforcement of Schedule H laws in India is lax, compared to the more restrictive Schedule X, for which a mandatory documentation trail must be maintained. ...
Effect of alendronate and MK-677 (a growth hormone secretagogue), individually and in combination, on markers of bone turnover ... Murphy MG, Weiss S, McClung M, Schnitzer T, Cerchio K, Connor J, Krupa D, Gertz BJ; MK-677/Alendronate Study Group. ...
November 2007). "Teriparatide or alendronate in glucocorticoid-induced osteoporosis". The New England Journal of Medicine. 357 ...
"Weekly oral alendronate in mevalonate kinase deficiency". Orphanet Journal of Rare Diseases. 8: 196. doi:10.1186/1750-1172-8- ...
Işeri SO, Sener G, Yüksel M, Contuk G, Cetinel S, Gedik N, Yegen BC (December 2005). "Ghrelin against alendronate-induced ...
This compound became known as Alendronate or Fosamax. In further works he examined the role of steroid in bone metabolism and ...
Newcastle upon Tyne July 1971 "In Brief: Effervescent Alendronate". The Medical Letter. October 15, 2012. Baynes, T.S., ed. ( ...
Brand names include Actonel (risedronate/alendronate), made by Merck Pharmaceuticals. Other drugs include Pamidronate, made by ...
Commonly used drugs are bisphosphonates including alendronate, risedronate, and ibandronate; selective estrogen receptor ...
Alendronate sodium is given as tablets once daily for six months; patients should wait at least 30 minutes after taking before ...
For this reason, other bisphosphonates, like alendronate, are preferred when fighting osteoporosis. To prevent bone resorption ...
Common examples are alendronate (a bisphosphonate, commonly prescribed for osteoporosis), cytotoxic drugs (e.g. methotrexate, i ... a little known adverse effect of alendronate: review of the literature". Journal of Oral and Maxillofacial Surgery. 70 (4): 830 ...
CS1 maint: Extra text: authors list (link) Agarwala, S; Jain, D; Joshi, Vr; Sule, A (Mar 2005). "Efficacy of alendronate, a ...
Alendronate reduces the risk of hip, vertebral, and wrist fractures by 35-39%. In December 2013, Merck agreed to pay a total of ... Fosamax (alendronate) is a bisphosphonate used for the treatment of post-menopausal osteoporosis and for the prevention of ... "Systematic review and meta-analysis of the efficacy and safety of alendronate and zoledronate for the treatment of ... the North American Menopause Society and the UK National Osteoporosis Guideline Group recommend alendronate and certain other ...
The bisphosphate drug alendronate may decrease the risk of a fracture, in women that have both bone loss and a previous ... Wells, GA; Cranney, A; Peterson, J; Boucher, M; Shea, B; Robinson, V; Coyle, D; Tugwell, P (Jan 23, 2008). "Alendronate for the ...
FPPS is the target of bisphosphonate drugs such as Fosamax (alendronate) and Actonel (risedronate). Bisphosphonate drugs are ...
Tomlin JL, Sturgeon C, Pead MJ, Muir P (29 July 2000). "Use of the bisphosphonate drug alendronate for palliative management of ... Some current studies indicate osteoclast inhibitors such as alendronate and pamidronate may have beneficial effects on the ...
Combined abaloparatide and alendronate therapy reduced significantly the incidence of vertebral and nonvertebral fractures. A ... received additional 2 years of 70 mg of alendronate, Vitamin D (400 to 800 IU), and calcium (500-1000 mg) supplementation daily ... "Eighteen Months of Treatment With Subcutaneous Abaloparatide Followed by 6 Months of Treatment With Alendronate in ...
Duque G; Rivas D (October 2007). "Alendronate has an anabolic effect on bone through the differentiation of mesenchymal stem ...
... placebo-controlled trial of alendronate treatment for fibrous dysplasia of bone". The Journal of Clinical Endocrinology and ...
Use of alendronate has been studied to prevent TRs and decrease progression of existing lesions. True dental caries is uncommon ...
Finally, osteoclast inhibition by the bisphosphonate alendronate has correlated with decreased HSCs and bone marrow engraftment ...
Some studies have found oral and intravenous bisphosphonates, such as oral alendronate and intravenous pamidronate, equivalent. ... DiMeglio LA, Peacock M (2006). "Two-year clinical trial of oral alendronate versus intravenous pamidronate in children with ... "Effects of oral alendronate on BMD in adult patients with osteogenesis imperfecta: a 3-year randomized placebo-controlled trial ...
Alendronate: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Continue to take alendronate even if you feel well. Do not stop taking alendronate without talking to your doctor, but talk to ... Before taking alendronate,. *tell your doctor and pharmacist if you are allergic to alendronate or any other medications. ... Talk to your doctor about the risks of taking alendronate.. Alendronate may cause other side effects. Call your doctor if you ...
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A list of US medications equivalent to Alendronate Sodium Hainan is available on the Drugs.com website. ... Alendronate Sodium Hainan is a medicine available in a number of countries worldwide. ... Alendronate. Alendronic Acid sodium monohydrate (a derivative of Alendronic Acid) is reported as an ingredient of Alendronate ... Alendronate Sodium Hainan may be available in the countries listed below.. Ingredient matches for Alendronate Sodium Hainan. ...
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Information about this alendronate-oral-route. Pregnancy Category. Explanation. All Trimesters. C. Animal studies have shown an ... Alendronate may make these conditions worse. Proper Use. This medicine comes with a Medication Guide and a patient information ... Alendronate is used to prevent and treat osteoporosis (thinning of the bone) in women after menopause. This medicine may also ... Use of alendronate is not indicated in children. Geriatric Appropriate studies performed to date have not demonstrated ...
Alendronate 5 mg/day % (n=642) Placebo % (n=648) Alendronate 5 mg/day % (n=361) Once Weekly Alendronate 35 mg % (n=362) ... Alendronate 10 mg/day % (n=146) Placebo % (n=95) Once Weekly Alendronate 70 mg % (n=109) Placebo % (n=58) ... See full prescribing information for alendronate sodium tablets, USP. Alendronate Sodium Tablets USP, for oral use Initial U.S ... Alendronate sodium * % (n=196) Placebo % (n=397) Alendronate sodium † % (n=3236) Placebo % (n=3223) ...
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Alendronate in Juvenile Osteoporosis. The safety and scientific validity of this study is the responsibility of the study ... Participants who have completed our earlier phase-1 and II study on alendronate in juvenile osteoporosis will be invited in ... Participants who earlier completed our phase I or phase II study on alendronate in juvenile osteoporosis, were invited to ... Participants who completed our earlier phase I/II study on alendronate in juvenile osteoporosis were invited to participate in ...
Alendronate sodium/colecalciferol) intended for persons living in Australia. ... Alendronate not only helps prevent the loss of bone but actually helps to rebuild bone and make bone less likely to fracture. ... The alendronate in DRONALEN PLUS works by slowing down the process of old bone being removed, which allows the bone-forming ... In addition to alendronate, DRONALEN PLUS also contains vitamin D, an essential nutrient required for calcium absorption and ...
Alendronate Osteoporosis Study. The safety and scientific validity of this study is the responsibility of the study sponsor and ... Drug Information available for: Alendronate sodium Genetic and Rare Diseases Information Center resources: Dermatomyositis ... Double-Blinded Controlled Trial of Alendronate for the Treatment of Childhood and Adolescent Glucocorticoid- Associated ... treatment of glucocorticoid-associated osteopenia and osteoporosis with 18 months of alendronate (FOSAMAX®, Merck & Co., Inc.) ...
Information about this alendronate-and-cholecalciferol-oral-route. Pregnancy Category. Explanation. All Trimesters. C. Animal ... Use of alendronate and cholecalciferol combination is not indicated in children. Geriatric Appropriate studies performed to ... Alendronate and cholecalciferol combination is used to treat osteoporosis (thinning of the bone) in women after menopause. This ... It is important that you tell all of your health care providers that you are taking alendronate and cholecalciferol combination ...
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After six weeks, the zoledronic acid group averaged 26 ng/mL whereas the mean among patients taking alendronate was 37 ng/mL (P ... She noted that the biomarkers were "already highly suppressed" in the alendronate group at the six-week mark. "Im actually ... Source Reference: Hadji P, et al "The Rapid Onset and Sustained Efficacy (ROSE) study: zoledronic acid vs alendronate -- first ... She also said that, in and of themselves, the results werent a reason to prefer zoledronic acid over alendronate. ...
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Effect of alendronateBisphosphonate10mg70MGTabletsBone resorptionCholecalciferolDosageFractureEffects of AlendronateEffectiveness of alendronateObserved in the alendronate groupTabletTrihydrateTreat osteoporosisInteractionsPostmenopausal osteoporosisLong-term alendronateTake alendronate solutionTaking alendronate sodiumTreatmentFemoralDose of alendronatePatients taking alenDrugsMedicationsIngredientDosesDaily alendronateCalcium carbonateOral1995Prevent osteoporosisPlaceboGlucocorticoid-inducedMerckVitamin D3MedicationZoledronicIncluding hip fracturesAllergicAbsorptionPreventionTeriparatideOsteoporosis-related fracturesDroe nateEsophagus problemsLumbarDrugAtrial FibrillationPharmacy
- Presents a letter to the editor in response to the article about the comparison of the effect of alendronate and risedronate on the upper gastrointestinal mucosa by endoscopy. (ebscohost.com)
- Effect of alendronate and MK-677 (a growth hormone secretagogue), individually and in combination, on markers of bone turnover and bone mineral den. (nih.gov)
- In conclusion, the anabolic effect of GH, as produced through the GH secretagogue MK-677, attenuated the indirect suppressive effect of alendronate on bone formation, but did not translate into significant increases in BMD at sites other than the femoral neck. (nih.gov)
- The article presents information about a study on the effect of alendronate on vertebral fracture (VF) in women with osteopenia. (ebscohost.com)
- 1 However, similar results have been found in meta-analyses demonstrating the effect of alendronate in patients receiving glucocorticoids. (endocrinologyadvisor.com)
- Vitamin K mediates the carboxylation of osteocalcin, but the effect of alendronate therapy with or without vitamin K(2) supplementation remains unknown. (druglib.com)
- The purpose of the present study was to investigate the potential effect of alendronate on the symptoms of knee osteoarthritis. (ac.ir)
- The Effect of Alendronate on Symptoms of Knee Osteoarthritis: A Randomized Controlled Trial', Iranian Journal of Medical Sciences , 35(1), pp. 9-15. (ac.ir)
- Vertebral Bone Mineral Density Measured With Quantitative Ct In Dogs: Preventive Effect Of Alendronate On Low Dose Prednisolone-Induced Osteopenia. (avmi.net)
- Alendronate sodium is a bisphosphonate that acts as a specific inhibitor of osteoclast -mediated bone resorption . (rxlist.com)
- Alendronate sodium hydrate (alendronate) is a bisphosphonate that potently inhibits bone resorption and is used to treat osteoporosis. (dovepress.com)
- To improve the transdermal bioavailability and safety of alendronate (ALN), a nitrogen-containing bisphosphonate, we developed self-dissolving microneedle arrays (MNs), in which ALN is loaded only at the tip portion of micron-scale needles by a dip-coating method (ALN(TIP)-MN). (mdpi.com)
- Alendronate Solution is a bisphosphonate. (drugster.info)
- Alendronate, a potent amino bisphosphonate, is prescribed to prevent glucocorticoid- induced osteopenia in humans. (avmi.net)
- Alendronate is a bisphosphonate (bis FOS fo nayt) medicine that alters bone formation and breakdown in the body. (nashunchealthcare.org)
- In osteoporosis and Paget's, the most popular first-line bisphosphonate drugs are alendronate and risedronate. (wikipedia.org)
- Effect of gradual accumulation of coronary artery calcium than those taking the 70mg awfully a pemphigus despondently of the Actonel clinical studies, fractures were reduced 65% in the 25-milligram jevons ALENDRONATE had 1. (wanadoo.es)
- I was retooking alendronate 70MG 3 month ago, but this week I got a lot of troubles as: diarrhea, Abdominal & stomach pain, heartburn, general feeling of discomfort or illness, full or bloated feeling. (medschat.com)
- The patients received either placebo or alendronate pills (70mg, weekly) in a blinded fashion for six months. (ac.ir)
- If you are taking the alendronate tablets, swallow the tablet with a full glass (6 to 8 ounces [180 to 240 mL]) of plain water. (medlineplus.gov)
- If you are taking the alendronate effervescent tablets, dissolve one effervescent tablet in a full glass (4 ounces [120 milliliters]) of plain, non-carbonated drinking water before drinking. (medlineplus.gov)
- These highlights do not include all the information needed to use Alendronate Sodium Tablets safely and effectively. (nih.gov)
- See full prescribing information for alendronate sodium tablets, USP. (nih.gov)
- Alendronate sodium tablets, USP are indicated for the treatment of osteoporosis in postmenopausal women. (nih.gov)
- In postmenopausal women, alendronate sodium tablets, USP increase bone mass and reduces the incidence of fractures, including those of the hip and spine (vertebral compression fractures). (nih.gov)
- Please read this leaflet carefully before you start using APO-Alendronate Tablets. (nps.org.au)
- Alendronate and cholecalciferol tablets need to be taken once every week. (canadapharmacy.com)
- Please read this leaflet carefully before you start using Alendronate Plus D3 Sandoz 70 mg/140 mcg Tablets. (nps.org.au)
- These tablets are manufactured by Mylan Pharmaceuticals and they list them as containing 70mgs of Alendronate. (medschat.com)
- These symptoms justify to some man, gubler's tapeworm that there is an fact of sheep and order alendronate tablets of fibula midnight these dogs appear severe and tinued co-operation about the antiseptic point. (thevhf.com)
- We hypothesized that administration of MK-677, an orally active GH secretagogue, together with alendronate, a potent inhibitor of bone resorption, would maintain a higher bone formation rate relative to that seen with alendronate alone, thereby generating greater enhancement of bone mineral density (BMD) in women with postmenopausal osteoporosis. (nih.gov)
- Alendronate, which is an aminobisphosphonate, potently inhibits osteoclastic bone resorption. (acpjc.org)
- Alendronate inhibits osteoclast-mediated bone-resorption. (wikipedia.org)
- But while pyrophosphate inhibits both osteoclastic bone resorption and the mineralization of the bone newly formed by osteoblasts, alendronate specifically inhibits bone resorption without any effect on mineralization at pharmacologically achievable doses. (wikipedia.org)
- Use of alendronate and cholecalciferol combination is not indicated in children. (mayoclinic.org)
- Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of alendronate and cholecalciferol combination in the elderly. (mayoclinic.org)
- Food and beverages (eg, mineral water, coffee, tea, or juice) will decrease the amount of alendronate and cholecalciferol combination absorbed by the body. (mayoclinic.org)
- Online pharmacies in our program do not offer Alendronate sodium/Cholecalciferol (vitamin d3) 70 mg/5600iu for sale, but you can find the discounted U.S. price below. (pharmacychecker.com)
- Higher Alendronate / cholecalciferol doses were again correlated with fewer severe bone, joint, or dystrophic muscle pain collected continuously during the monitoring stay. (todaysparentusa.com)
- Alendronate / cholecalciferol may really cause or symptoms worsen convulsions. (todaysparentusa.com)
- Drate plus d has the main ingredients of Alendronate sodium + Cholecalciferol. (medschat.com)
- This is a combination medication that contains alendronate and cholecalciferol. (canoe.com)
- Each white-to-off-white, capsule-shaped tablet debossed with 'A70' on one side and '2800' on the other contains 91.37 mg of alendronate monosodium salt monohydrate, which is the molar equivalent of 70 mg of alendronate, and 70 µg of cholecalciferol equivalent to 2800 IU of vitamin D3. (canoe.com)
- The recommended dose of alendronate - cholecalciferol is one tablet once weekly. (canoe.com)
- The overall appropriate dosage of alendronate - cholecalciferol for you is determined by your doctor and is based on how much vitamin D you require. (canoe.com)
- The recommended dosage is one 70 mg alendronate/2800 international units vitamin D 3 or one 70 mg alendronate/5600 international units vitamin D 3 tablet once weekly. (rxlist.com)
- PDS was administered to the PDS group at a dosage of 2 mg/kg for 2 weeks, 1 mg for 4 weeks, and 0.5 mg for 3 weeks daily per oral, and in the alendronate co-administration group, 2 mg/kg alendronate was administered for 9 weeks in addition to the same dosage of PDS used in the PDS group. (avmi.net)
- Alendronate not only helps prevent the loss of bone but actually helps to rebuild bone and make bone less likely to fracture. (news-medical.net)
- Unless I saw a head-to-head trial with a difference in fracture rates at that point in time, I wouldn't [pick zoledronic acid over alendronate]," Shane said. (medpagetoday.com)
- Only one out of 171 evaluable patients receiving teriparatide had radiographic evidence of a vertebral fracture, while 10 of 165 evaluable patients on alendronate had such fractures ( P =0.004). (medpagetoday.com)
- Although the femoral neck is an important site for fracture prevention, the lack of enhancement in bone mass at other sites compared with that seen with alendronate alone is a concern when weighed against the potential side effects of enhanced GH secretion. (nih.gov)
- Older adults taking alendronate and oral glucocorticoids are at a lower risk for nonvertebral fracture, including hip fracture , according to a retrospective cohort study published in the Journal of Endocrinology & Metabolism . (endocrinologyadvisor.com)
- 3-7 Therefore, the investigators concluded, "this study showed that alendronate use was associated with a lower risk of nonvertebral fracture, including a lower risk of hip fracture. (endocrinologyadvisor.com)
- Bergman J, Nordström A, Nordström P. Alendronate use and the risk of nonvertebral fracture during glucocorticoid therapy: a retrospective cohort study [published online November 3, (endocrinologyadvisor.com)
- 1 indicates reduction in risk for hip fracture with use of alendronate. (annals.org)
- Effects of continuing or stopping alendronate after 5 years of treatment: the Fracture Intervention Trial Long-term Extension (FLEX): a randomized trial. (bmj.com)
- Alendronate and raloxifene have a similar hip fracture risk (hazard ratio [HR] 1.03, 95% confidence interval [CI] 0.94-1.13), but alendronate users are more likely to have vertebral fractures (HR 1.07, 95% CI 1.01-1.14). (eur.nl)
- Raloxifene is as effective as alendronate and may remain an option in the prevention of osteoporotic fracture. (eur.nl)
- Our results indicate that alendronate with alfacalcidol can maintain BMD and protects against high-dose GC-induced bone loss and bone fracture. (jrheum.org)
- Alendronate decreases the risk of femoral neck fracture by suppressing bone turnover, and also decreases the serum total osteocalcin level. (druglib.com)
- Read the side effects of Alendronate as described in the medical literature. (medindia.net)
- These are not all the possible side effects of alendronate. (rxwiki.com)
- The primary aim of this study was to compare the effects of alendronate versus placebo on BMD and biochemical measurements of bone turnover in patients with PBC-associated bone loss. (elsevier.com)
- Do proton-pump inhibitors (PPIs) reduce the effectiveness of alendronate for preventing hip fractures? (annals.org)
- PPI use did not attenuate the effectiveness of alendronate for preventing forearm (4.5/1000 patient-y in PPI users vs 4.3/1000 patient-y in nonusers), humerus (2.9 vs 2.5/1000 patient-y), or spine (2.7 vs 1.3/1000 patient-y) fractures. (annals.org)
- Concurrent use of proton-pump inhibitors, particularly at ≥ 1 dose-year, was associated with reduced effectiveness of alendronate for preventing hip fractures in older adults. (annals.org)
- Finally, the effectiveness of alendronate as a therapy for postmenopausal women with established osteoporosis should not be used to infer that alendronate would also prevent bone loss from estrogen deficiency. (acpjc.org)
- We studied the comparative effectiveness of alendronate (AL) and zoledronic acid (ZOL) on bone mass improvement in transfusion-dependent thalassemia (TDT) patients a year after treatment. (springer.com)
- The increase in BMD observed in the alendronate group compared with the placebo group was statistically significant at both the lumbar spine (P = .01) and the femoral neck (P = .01). (druglib.com)
- After 1 year, a significantly larger improvement (P = .005) in spine BMD was observed in the alendronate group (0.09 ± 0.03 g/cm 2 SD from baseline) compared with the placebo group (-0.003 ± 0.02 g/cm 2 SD from baseline). (elsevier.com)
- Alendronate comes as a tablet, an effervescent tablet, and a solution (liquid) to take by mouth. (medlineplus.gov)
- Not lie down for at least 30 minutes after taking alendronate sodium tablet and until after food. (nih.gov)
- Each white, oval, biconvex tablet engraved 'ALE70' on one side contains alendronate sodium equivalent to 70 mg of alendronate. (medbroadcast.com)
- When used for postmenopausal women, the recommended dose of alendronate to treat osteoporosis is one 10 mg tablet daily or 70 mg once weekly. (medbroadcast.com)
- Each white-to-off-white, round, biconvex, uncoated tablet debossed with 'F' on one side and '18' on the other contains sodium alendroante equivalent to 10 mg of alendronate. (medbroadcast.com)
- Each white, round, flat-faced, bevelled-edged tablet engraved 'A' on one side and '5' on the other contains 6.53 mg of alendronate monosodium salt trihydrate, which is the molar equivalent of 5 mg of alendronate. (canada.com)
- Each white, round, biconvex tablet engraved 'APO' on one side and '10' on the other contains alendronate sodium equivalent to alendronate 10 mg. (canada.com)
- Each tablet contains 13.05 mg of alendronate monosodium salt trihydrate, which is the molar equivalent of 10 mg of alendronate. (canada.com)
- Each white, oval, biconvex tablet engraved 'APO' on one side and 'ALE70' on the other contains 91.35 mg of alendronate sodium salt trihydrate, which is the molar equivalent of 70 mg of alendronate. (canada.com)
- For prevention, alendronate is taken daily as a 5 mg tablet or weekly as a 35 mg tablet. (nof.org)
- The alendronate tablet must be taken first thing in the morning after waking up and on an empty stomach. (nof.org)
- Alendronate comes in tablet form. (rxwiki.com)
- Alendronate Sodium tablet should be taken in the morning, 30 minutes before drinking or eating anything or using any other medication. (genericdoctor.com)
- Alendronate sodium is chemically described as (4-amino-1-hydroxybutylidene) bisphosphonic acid monosodium salt trihydrate. (rxlist.com)
- Alendronate Sodium Trihydrate Report by Material, Application, and Geography - Global Forecast to 2021 is a professional and in-depth research report on the world's major regional market conditions, focusing on the main regions (North America, Europe and Asia-Pacific) and the main countries (United States, Germany, united Kingdom, Japan, South Korea and China). (absolutereports.com)
- Alendronate is used to treat and prevent osteoporosis (a condition in which the bones become thin and weak and break easily) in women who have undergone menopause (''change of life,'' end of menstrual periods) and to treat osteoporosis in men. (medlineplus.gov)
- Alendronate is also used to treat osteoporosis in men and women who are taking corticosteroids (a type of medication that may cause osteoporosis in some patients). (medlineplus.gov)
- Alendronate is used to prevent and treat osteoporosis (thinning of the bone) in women after menopause. (mayoclinic.org)
- Alendronate is a prescription medication used to treat osteoporosis and Paget's disease in men and women. (rxwiki.com)
- Alendronate is used to treat osteoporosis caused by menopause, steroid use, or gonadal failure. (nashunchealthcare.org)
- Other beverages (including mineral water), food, and some medications are likely to reduce the absorption of alendronate [see DRUG INTERACTIONS ]. (rxlist.com)
- This is not a complete list of alendronate drug interactions. (rxwiki.com)
- Alendronate Sodium has interactions with calcium supplements/ antacids, aspirin, and non-steroidal anti-inflammatory drugs. (genericdoctor.com)
- Recently, however, there is a concern regarding long bone insufficiency fractures related to long-term alendronate therapy. (hindawi.com)
- We report a case of bilateral femoral insufficiency fractures likely related to long-term alendronate therapy, the classic symptoms, signs, and treatment of these fractures. (hindawi.com)
- Recently, however, there is an emerging concern regarding long bone stress fractures secondary to long-term alendronate intake. (hindawi.com)
- We present a case of bilateral femoral shaft insufficiency fractures secondary to long-term alendronate therapy. (hindawi.com)
- the effect of long-term alendronate on bone turnover and strength is unknown ( 1 ). (acpjc.org)
- Take Alendronate Solution by mouth on an empty stomach in the morning at least 30 minutes before your first food, drink, or other medicine of the day. (drugster.info)
- Do NOT take Alendronate Solution at bedtime or before you get out of bed in the morning. (drugster.info)
- Drink at least 2 oz (1/4 cup) of plain water after you take Alendronate Solution. (drugster.info)
- Be sure you understand how to take Alendronate Solution. (drugster.info)
- Participants who earlier completed in our open labeled or double blind study of alendronate treatment for juvenile osteoporosis, were invited for one clinical visit. (clinicaltrials.gov)
- They were randomized in a 2:1 ratio to 5 mg of zoledronic acid delivered in a single infusion or weekly treatment with 70 mg of oral alendronate. (medpagetoday.com)
- However, treatment discontinuation because of adverse events was substantially more common in the alendronate group (10% versus 1%, P not reported). (medpagetoday.com)
- Teriparatide has an estimated annual treatment cost of nearly $7,000, about eight times as much as for alendronate. (medpagetoday.com)
- Alendronate is approved for the prevention and treatment of osteoporosis in postmenopausal women and for the treatment of osteoporosis in men. (nof.org)
- A prospective open-labeled trial was conducted to compare the effects of short-term combined treatment with alendronate (ALN) and ECT on bone mineral density (BMD) and bone turnover with those of single treatment with ALN in postmenopausal women with osteoporosis. (dovepress.com)
- In this review, this new formulation of alendronate sodium hydrate (oral jelly) is introduced and discussed in terms of osteoporosis treatment. (dovepress.com)
- This study provides evidence that treatment with alendronate in this defined range of osteopenic patients prevents incident fractures in those who have prevalent VFs. (ebscohost.com)
- If you have low blood calcium before you start taking alendronate, it may get worse during treatment. (rxwiki.com)
- Use of PPIs at baseline (prescription filled ≤ 12 mo before index date) or concurrent with alendronate (prescription filled during first 36 mo of treatment with alendronate). (annals.org)
- Teriparatide (TPTD) and alendronate (ALN) are widely used in clinical for treatment of osteoporosis. (bmj.com)
- Q In postmenopausal women with low bone mineral density (BMD) who had been receiving daily alendronate for a mean of 5 years, what is the effect of continuing alendronate treatment for 5 years compared with discontinuing it? (bmj.com)
- Alendronate Sodium is a medicine used in the treatment and prevention of osteoporosis which is caused by the use of steroids or menopause. (genericdoctor.com)
- Four patients discontinued alendronate therapy, and we analyzed the remaining 44 patients (23 in group A and 21 in group AK) who completed 1 year of treatment. (druglib.com)
- We conducted a randomized, multicenter, open-label trial to compare the efficacy of alendronate, calcitriol, and simple vitamin D in prevention and treatment of glucocorticoid-induced bone loss. (garvan.org.au)
- These data do not suggest any difference between simple vitamin D and calcitriol but do show that alendronate was superior to either treatment for glucocorticoid induced bone loss. (garvan.org.au)
- Our results demonstrate that alendronate treatment opposes growth of orthotopic PC-3 tumors and decreases tumor metastasis to prostate-draining lymph nodes. (biomedcentral.com)
- Manufacturer: Jubilant Cadista Pharmaceuticals Inc. Alendronate is used in the treatment of prevention of osteoporosis. (medschat.com)
- Serum ionic fluoride concentrations are significantly decreased after treatment with alendronate in patients with osteoporosis. (semanticscholar.org)
- This study examined the cost-effectiveness of vitamin K 1 versus alendronate, for the treatment of osteoporosis, and it determined the expected value of sample information from a head-to-head clinical trial of the two interventions. (york.ac.uk)
- This study examined the cost-effectiveness of vitamin K 1 versus alendronate for the treatment of osteoporosis. (york.ac.uk)
- Alendronate use is associated with low-energy femoral shaft fractures. (greenmedinfo.com)
- The percent change in BMD in the alendronate group was +3.7% and +3.5% at the lumbar spine and the femoral neck, respectively, whereas in the placebo group, it was -1.4% and -0.7% at the lumbar spine and the femoral neck, respectively. (druglib.com)
- CONCLUSIONS: There were statistically significant increases in BMD at both the lumbar spine (P = .01) and the femoral neck (P = .01) with alendronate therapy. (druglib.com)
- Alendronate monotherapy does not decrease carboxylation of osteocalcin, and combination of vitamin K(2) and alendronate brings further benefits on both osteocalcin carboxylation and BMD of femoral neck in postmenopausal women with osteoporosis. (druglib.com)
- A larger improvement (P = .046) was also observed in the femoral BMD of alendronate patients versus placebo. (elsevier.com)
- If you miss a dose of Alendronate Solution, do not take it later in the day. (drugster.info)
- Researchers used national Swedish registers from hospitals and ambulatory specialist care practices to identify 16,890 patients taking alendronate and matched them with 16,890 nonusers. (endocrinologyadvisor.com)
- 1 In addition, patients taking alendronate experienced 34% fewer hip fractures compared with nonusers, all of whom received concomitant glucocorticoid therapy. (endocrinologyadvisor.com)
- After you take alendronate, do not eat, drink, or take any other medications (including vitamins or antacids) for at least 30 minutes. (medlineplus.gov)
- tell your doctor and pharmacist if you are allergic to alendronate or any other medications. (medlineplus.gov)
- Glucocorticoids are often administered with osteoporosis medications , most commonly alendronate, to prevent fractures. (endocrinologyadvisor.com)
- Alendronate and raloxifene are among the most popular anti-osteoporosis medications. (eur.nl)
- Post your question or story about Alendronate and connect with others who have experience with the same medications. (medschat.com)
- placebo data were compared with data from the women who received all alendronate doses combined. (acpjc.org)
- Risk of upper GI adverse reactions is increased by concomitant use of aspirin and alendronate doses over 10 mg/day. (drugster.info)
- All acid sodium phenomena of this student, of lengthened blister, know that sufficient tains arise from depressed doses, causes forfeited by some pale lung, by purpose, by occasional week to continue the place order cheap alendronate online uk. (thevhf.com)
- Our aim was to identify patients with low bone mineral density (BMD) using a screening program, and then evaluate the benefit of daily alendronate. (monash.edu)
- Conclusions:Improvement in bone mineral density has been demonstrated at the lumbar spine, but not hip, by per protocol analysis, with daily alendronate, at 12 months. (monash.edu)
- If you are taking the alendronate oral solution, drink at least 2 ounces (60 milliliters [1/4 cup]) of water after taking alendronate oral solution. (medlineplus.gov)
- In the randomized, double-blind trial, 428 patients were assigned to either 20 mcg of teriparatide or 10 mg of oral alendronate daily for 18 months. (medpagetoday.com)
- Once-weekly alendronate oral jelly was approved in 2012 by the Ministry of Health, Labour, and Welfare of Japan as the world's first drug for osteoporosis in a jelly formulation. (dovepress.com)
- OBJECTIVE: To evaluate the efficacy and safety of oral alendronate sodium therapy once daily in preventing glucocorticoid-induced bone loss in patients with immunobullous skin diseases treated with long-term glucocorticoid therapy. (druglib.com)
- Interventions The patients were randomized to receive either oral alendronate sodium (10 mg/d) or a matching placebo for 12 months. (druglib.com)
- To determine whether oral alendronate increases bone mineral density and decreases the incidence of vertebral fractures and loss of height in postmenopausal women with osteoporosis. (acpjc.org)
- Although in this study oral alendronate appears to be well tolerated in patients with PBC, larger studies are needed to formally evaluate safety. (elsevier.com)
- Participants earlier were treated with alendronate for 12 months either in an open label study (without control) or double blind study with placebo control. (clinicaltrials.gov)
- A Phase 1 Randomized, Double-Blind, Placebo-Controlled Single and Multiple Ascending Dose Study of the Safety and Tolerability of Intravenous LLP2A-Alendronate in Adult Men and Women with Osteopenia Secondary to Corticosteroids. (clinicaltrials.gov)
- Patients who received MK-677 alone or placebo through month 12 received MK-677 (25 mg) plus alendronate (10 mg) from months 12-18. (nih.gov)
- Prevention of Glucocorticoid-Induced Osteoporosis in Immunobullous Diseases With Alendronate: A Randomized, Double-blind, Placebo-Controlled Study. (druglib.com)
- RESULTS: A total of 29 patients (alendronate [n = placebo [n = were evaluated. (druglib.com)
- 01) in the alendronate group but not in the placebo group. (druglib.com)
- Women in all 3 alendronate groups had significant increases in bone mineral density compared with women in the placebo group, who had significant decreases in bone mineral density. (acpjc.org)
- 1.0 commenced on alendronate/calcium (10 mg/600 mg day) or placebo/calcium, in a double blind randomized controlled trial. (monash.edu)
- 66 alendronate/calcium, 79 placebo/calcium with 24 and 26 withdrawals, respectively. (monash.edu)
- The efficacy of alendronate was from a meta-analysis and the efficacy of vitamin K 1 was from a double-blind randomised controlled trial (RCT) that compared vitamin K 1 with placebo, in Canada. (york.ac.uk)
- Although it has been suggested that alendronate might improve bone mineral density (BMD) in PBC, no randomized placebo-controlled trial has been conducted. (elsevier.com)
- Patients with a PBC and BMD t score of less than -1.5 were randomized to receive 70 mg per week of alendronate or placebo over 1 year. (elsevier.com)
- In conclusion, in patients with PBC-related bone loss, alendronate significantly improves BMD compared with placebo. (elsevier.com)
- Lindor, Keith D. / Alendronate improves bone mineral density in primary biliary cirrhosis : A randomized placebo-controlled trial . (elsevier.com)
- I feel like to remind that ALENDRONATE has remove the service tax from Clinical Research in the paper would have been diagnosed with Osteoporosis 6 years ago and have been recalcitrant, with Merck winning 2 cases, losing 2 and receiving a split biochemistry on a daily basis, and they all are abusers. (wanadoo.es)
- A Merck spokeswoman said that ALENDRONATE has no effect against preventing unpaid dribbling of bone legislator, membership benefit of defiled threonine. (wanadoo.es)
- Alendronate with either 2,800 IU or 5,600 IU of vitamin D3 provides another option for a source of vitamin D. Weekly alendronate with 2,800 IU of vitamin D3 is the equivalent of taking 400 IU daily, while weekly alendronate with 5,600 IU of vitamin D3 is the equivalent of taking 800 IU daily. (nof.org)
- Explain to interested patients that both zoledronic acid and alendronate are FDA-approved for treating osteoporosis. (medpagetoday.com)
- Those that were considered drug-related included flu-like symptoms (29% of zoledronic acid patients, 1% of the alendronate group) and gastrointestinal complaints (20% of alendronate patients, 7% of zoledronic acid patients). (medpagetoday.com)
- She also said that, in and of themselves, the results weren't a reason to prefer zoledronic acid over alendronate. (medpagetoday.com)
- In addition to alendronate, DRONALEN PLUS also contains vitamin D, an essential nutrient required for calcium absorption and healthy bones. (news-medical.net)
- Decreased alendronate absorption. (drugster.info)
- Absorption of alendronate is decreased by food. (drugster.info)
- After absorption in the bone, alendronate has an estimated terminal elimination half-life of 10 years. (wikipedia.org)
- Teriparatide increased hip BMD by 3.8% while it rose 2.4% in the alendronate group. (medpagetoday.com)
- Twice as many patients on teriparatide as on alendronate did not complete the planned therapy because of adverse effects. (medpagetoday.com)
- A 2006 study from Stanford University researchers found that teriparatide is less cost-effective than alendronate for postmenopausal women with severe osteoporosis. (medpagetoday.com)
- That finding assumed that teriparatide was 35% more effective than alendronate in reducing fractures -- about the same as in the new study. (medpagetoday.com)
- Address reprint requests to Dr. New data collected by the National Institutes of Health showed that ALENDRONATE could read ALENDRONATE was that if a drug airway braun. (wanadoo.es)
- DC clupea prolongation ALENDRONATE has an alert sent to doctors by drug studio Novartis, which says patients and people taking blood- thinners may not come back normal. (wanadoo.es)
- Develop a rapid and simple experimental method to determine the fractions of the drug, alendronate (ALN), encapsulated and as a free form distributed in the liposomal suspension, and the physical state of the encapsulated drug. (omicsonline.org)
- alendronate cause positive for what drug? (medschat.com)
- Click Precautions and Warnings With Alendronate to learn more, including information on who should not take the drug. (emedtv.com)