Alendronate: A nonhormonal medication for the treatment of postmenopausal osteoporosis in women. This drug builds healthy bone, restoring some of the bone loss as a result of osteoporosis.11-beta-Hydroxysteroid Dehydrogenase Type 1: A low-affinity 11 beta-hydroxysteroid dehydrogenase found in a variety of tissues, most notably in LIVER; LUNG; ADIPOSE TISSUE; vascular tissue; OVARY; and the CENTRAL NERVOUS SYSTEM. The enzyme acts reversibly and can use either NAD or NADP as cofactors.Osteoporosis, Postmenopausal: Metabolic disorder associated with fractures of the femoral neck, vertebrae, and distal forearm. It occurs commonly in women within 15-20 years after menopause, and is caused by factors associated with menopause including estrogen deficiency.Etidronic Acid: A diphosphonate which affects calcium metabolism. It inhibits ectopic calcification and slows down bone resorption and bone turnover.Diphosphonates: Organic compounds which contain P-C-P bonds, where P stands for phosphonates or phosphonic acids. These compounds affect calcium metabolism. They inhibit ectopic calcification and slow down bone resorption and bone turnover. Technetium complexes of diphosphonates have been used successfully as bone scanning agents.Bone Density: The amount of mineral per square centimeter of BONE. This is the definition used in clinical practice. Actual bone density would be expressed in grams per milliliter. It is most frequently measured by X-RAY ABSORPTIOMETRY or TOMOGRAPHY, X RAY COMPUTED. Bone density is an important predictor for OSTEOPOROSIS.Osteoporosis: Reduction of bone mass without alteration in the composition of bone, leading to fractures. Primary osteoporosis can be of two major types: postmenopausal osteoporosis (OSTEOPOROSIS, POSTMENOPAUSAL) and age-related or senile osteoporosis.Bone Remodeling: The continuous turnover of BONE MATRIX and mineral that involves first an increase in BONE RESORPTION (osteoclastic activity) and later, reactive BONE FORMATION (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium HOMEOSTASIS. An imbalance in the regulation of bone remodeling's two contrasting events, bone resorption and bone formation, results in many of the metabolic bone diseases, such as OSTEOPOROSIS.Fractures, Bone: Breaks in bones.Teriparatide: A polypeptide that consists of the 1-34 amino-acid fragment of human PARATHYROID HORMONE, the biologically active N-terminal region. The acetate form is given by intravenous infusion in the differential diagnosis of HYPOPARATHYROIDISM and PSEUDOHYPOPARATHYROIDISM. (Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Englewood, CO, 1995)Femoral Fractures: Fractures of the femur.Bone Resorption: Bone loss due to osteoclastic activity.Femur: The longest and largest bone of the skeleton, it is situated between the hip and the knee.Spinal Fractures: Broken bones in the vertebral column.Bone and Bones: A specialized CONNECTIVE TISSUE that is the main constituent of the SKELETON. The principle cellular component of bone is comprised of OSTEOBLASTS; OSTEOCYTES; and OSTEOCLASTS, while FIBRILLAR COLLAGENS and hydroxyapatite crystals form the BONE MATRIX.Raloxifene: A second generation selective estrogen receptor modulator (SERM) used to prevent osteoporosis in postmenopausal women. It has estrogen agonist effects on bone and cholesterol metabolism but behaves as a complete estrogen antagonist on mammary gland and uterine tissue.Hydroxycholecalciferols: Hydroxy analogs of vitamin D 3; (CHOLECALCIFEROL); including CALCIFEDIOL; CALCITRIOL; and 24,25-DIHYDROXYVITAMIN D 3.Fractures, Spontaneous: Fractures occurring as a result of disease of a bone or from some undiscoverable cause, and not due to trauma. (Dorland, 27th ed)Collagen Type I: The most common form of fibrillar collagen. It is a major constituent of bone (BONE AND BONES) and SKIN and consists of a heterotrimer of two alpha1(I) and one alpha2(I) chains.Tibia: The second longest bone of the skeleton. It is located on the medial side of the lower leg, articulating with the FIBULA laterally, the TALUS distally, and the FEMUR proximally.Drugs, Generic: Drugs whose drug name is not protected by a trademark. They may be manufactured by several companies.Bone Diseases, MetabolicSpine: The spinal or vertebral column.Bone Demineralization Technique: Removal of mineral constituents or salts from bone or bone tissue. Demineralization is used as a method of studying bone strength and bone chemistry.Lumbar Vertebrae: VERTEBRAE in the region of the lower BACK below the THORACIC VERTEBRAE and above the SACRAL VERTEBRAE.Geranyltranstransferase: An enzyme involved in the MEVALONATE pathway, it catalyses the synthesis of farnesyl diphosphate from isopentenyl diphosphate and dimethylallyl diphosphate.Clodronic Acid: A diphosphonate which affects calcium metabolism. It inhibits bone resorption and soft tissue calcification.

Alendronate gastric ulcers. (1/413)

BACKGROUND: It appears likely that drugs other than NSAIDs may cause ulcers and ulcer complications (e.g. potassium chloride). Alendronate (Fosamax) is used in the treatment and prevention of metabolic bone disease and has also been associated with severe oesophageal damage and stricture. We have previously shown that the dose of alendronate used for Paget's disease (40 mg) causes gastric damage similar to NSAIDs. The usual dose for the treatment of postmenopausal osteoporosis is 10 mg per day. AIM: To investigate whether the 10 mg dose of alendronate causes gastric ulcers. METHODS: We performed an endoscopist-blind, crossover, randomized, single-centre comparison of 10 mg of alendronate/day and placebo in volunteers aged 40 years or more. Video-endoscopy was used to evaluate the presence and degree of mucosal damage to the oesophagus, stomach, or duodenal bulb after 7 and 14 days of treatment. RESULTS: Twenty-four healthy volunteers participated, including 15 women and nine men, ranging in age from 41 to 52 years. Visible gastric mucosal damage was present in nine (38%) who received alendronate compared to three (13%) in the placebo group. There was a marked difference in the severity of mucosal damage; there were no ulcers or large erosions in those receiving placebo. In contrast, potentially clinically significant gastric mucosal injury was seen in six subjects receiving alendronate (two developed antral ulcers and four had large (4-8 mm) superficial antral erosions) compared to none in the placebo group (P = 0.0219). One subject developed oesophageal damage in the form of multiple linear superficial erosions in the mid and distal oesophagus. Duodenal injury was not seen. CONCLUSION: Alendronate causes gastric ulceration, suggesting that alendronate use may be associated with ulcer complications such as acute upper gastrointestinal bleeding. The results of this study suggest the need for post-marketing surveillance to clarify the nature, frequency and magnitude of any potential gastrointestinal side-effects associated with the use of this drug.  (+info)

Clinic visits and hospital admissions for care of acid-related upper gastrointestinal disorders in women using alendronate for osteoporosis. (2/413)

CONTEXT: About 1 in 3 women taking alendronate for osteoporosis report gastrointestinal symptoms, a rate much higher than that found during clinical trials. OBJECTIVE: To establish the frequency of outpatient visits and hospital admissions for acid-related upper gastrointestinal disorder (ARD) among women taking alendronate and to identify potential risk factors. METHODS: A retrospective database analysis identified 812 women with osteoporosis who had filled one or more 10-mg alendronate prescriptions from October 1995 through October 1996. RESULTS: One hundred (12.3%) of the 812 women received healthcare for ARD, a clinical encounter rate of 28.5 per 100 person-years. A reference group of 362,109 women from the same health plan had 17.6 ARD encounters per 100 person-years. Excluding women who had ARDs before receiving alendronate, alendronate users were 1.6 (95% CI = 1.2, 2.7) times more likely to have an ARD encounter than nonusers. Risk of having ARD increased with age [users aged 70 years and older had a relative risk of 1.5 (95% confidence interval (CI) 1.0-2.30) compared with younger women] and with concurrent use of nonsteroidal anti-inflammatory drugs (NSAIDS) (relative risk 1.7, 95% CI 1.1-2.6). CONCLUSIONS: Elderly alendronate users or those concurrently taking NSAIDS should be carefully monitored because of their high risk of having ARD. Cost/benefit analyses of alendronate treatment for osteoporosis should include costs of treating ARD.  (+info)

Alendronate induces antinociception in mice, not related with its effects in bone. (3/413)

The antinociceptive effect of alendronate was studied. The bisphosphonate was i.p. administered and two tests were carried out: acetic acid in mice and formalin test in rats. In the acetic acid test, alendronate induced a dose-dependent antinociceptive effect that was statistically significant for the doses of 10, 20 and 40 mg/kg, and could be detected 48 hr after its administration. In the formalin test, however, alendronate, at the doses of 10 and 20 mg/kg, did not modify the pain score nor the number of flinches, when it was administered either 30 or 60 min before the test. However it must be noted that doses inducing analgesic effect are close to those inducing toxicity.  (+info)

Larger increases in bone mineral density during alendronate therapy are associated with a lower risk of new vertebral fractures in women with postmenopausal osteoporosis. Fracture Intervention Trial Research Group. (4/413)

OBJECTIVE: To investigate whether the incidence of vertebral fractures is related to the magnitude of change in bone mineral density (BMD) during alendronate treatment. METHODS: Women in this study were age 55-81 years (n = 2,984). While participating in the Fracture Intervention Trial, they received 5 mg/day of alendronate for 2 years followed by 10 mg/day for the remaining 12-30 months of the study. Their BMD was measured at baseline and at 12 and 24 months, and spine radiographs were obtained at baseline and again at 36 or 48 months to identify new vertebral fractures. RESULTS: After 12 months of alendronate treatment, 35% of participants had increases of > or =3% in total hip BMD, and 21% had either decreased total hip BMD or no change. Women who had larger increases in total hip BMD during the first 12 months had a lower incidence of new vertebral fractures during the entire followup period. Only 3.2% of women with increases of > or =3% in total hip BMD experienced new vertebral fractures, whereas twice as many women (6.3%) whose BMD declined or stayed the same experienced new fractures (adjusted odds ratio 0.45, 95% confidence interval 0.27-0.72). Similar patterns were observed for spine BMD at 12 months, and for both sites using change in BMD at 24 months. CONCLUSION: Women with increases of > or =3% in BMD during the first 1 or 2 years of alendronate treatment had the lowest incidence of new vertebral fractures. These findings suggest that, among women taking antiresorptive agents, greater increases in BMD are associated with lower risk of new vertebral fractures.  (+info)

Farnesol and geranylgeraniol prevent activation of caspases by aminobisphosphonates: biochemical evidence for two distinct pharmacological classes of bisphosphonate drugs. (5/413)

Recently, advances have been made in understanding the molecular mechanisms by which bisphosphonate drugs inhibit bone resorption. Studies with the macrophage-like cell line J774 have suggested that alendronate, an amino-containing bisphosphonate, causes apoptosis by preventing post-translational modification of GTP-binding proteins with isoprenoid lipids. However, clodronate, a nonaminobisphosphonate, does not inhibit protein isoprenylation but can be metabolized intracellularly to a cytotoxic, beta-gamma-methylene (AppCp-type) analog of ATP. These observations raise the possibility that bisphosphonates can be divided into two groups with distinct molecular mechanisms of action depending on the nature of the R2 side chain. We addressed this question by directly comparing the ability of three aminobisphosphonates (alendronate, ibandronate, and pamidronate) and three nonaminobisphosphonates (clodronate, etidronate, and tiludronate) to inhibit protein isoprenylation and activate caspase-3-like proteases or to be metabolized to AppCp-type nucleotides by J774 cells. All three aminobisphosphonates inhibited protein isoprenylation and activated caspase-3-like proteases. Apoptosis and caspase activation after 24-h treatment with the aminobisphosphonates could be prevented by addition of farnesol or geranylgeraniol, confirming that these bisphosphonates inhibit the metabolic mevalonate pathway. No AppCp-type metabolites of the aminobisphosphonates could be detected by mass spectrometry. The three nonaminobisphosphonates did not inhibit protein isoprenylation or cause activation of caspase-3-like proteases, but were incorporated into AppCp-type nucleotides. Taken together, these observations clearly demonstrate that bisphosphonate drugs can be divided into two pharmacological classes: the aminobisphosphonates, which act by inhibiting protein isoprenylation, and the less potent nonaminobisphosphonates, which act through the intracellular accumulation of AppCp-type metabolites.  (+info)

Use of bone alkaline phosphatase to monitor alendronate therapy in individual postmenopausal osteoporotic women. (6/413)

BACKGROUND: Biochemical bone markers are sensitive to the changes in bone turnover that result from treatment of postmenopausal osteoporotic women with antiresorptive therapies. Although information is available on the use of bone markers in monitoring therapy in groups of subjects, less is known regarding how these markers perform in individual patients. METHODS: Serum bone alkaline phosphatase (bone ALP) concentrations, measured with the Tandem(R) Ostase(R) assay, were used to monitor the biochemical response of bone in postmenopausal women with osteoporosis receiving either 10 mg/day alendronate therapy (n = 74) or calcium supplementation (n = 148) for 24 months. RESULTS: Bone ALP decreased significantly from baseline at 3 months (P +info)

Prevention of osteoporosis and fractures. (7/413)

Osteoporosis and low bone density are associated with a risk of fracture as a result of even minimally traumatic events. The estimated lifetime risk of osteoporotic fracture is as high as 50 percent, especially in white and Asian women. The use of caffeine, tobacco and steroids is associated with a decrease in bone density. Cognitive impairment, vision problems and postural instability increase the risk of falling and sustaining a fracture. Medications such as long-acting sedative hypnotics, anticonvulsants and tricyclic antidepressants also increase this risk. Combinations of clinical and radiographic findings can predict fracture risk more effectively than bone densitometry, but often only after the first fracture has occurred. The addition of dietary calcium and/or vitamin D is clearly both cost-effective and significant in reducing the likelihood of fractures. Bisphosphonates reduce fracture risk but at a cost that may be prohibitive for some patients. Estrogen and estrogen-receptor modulators have not been well studied in randomized trials evaluating the reduction of fractures, but they are known to increase bone density. Pharmacologic therapy and the reduction of sensory and environmental hazards can prevent osteoporotic fractures in some patients.  (+info)

Prevention of osteocyte and osteoblast apoptosis by bisphosphonates and calcitonin. (8/413)

Glucocorticoid-induced osteoporosis may be due, in part, to increased apoptosis of osteocytes and osteoblasts, and bisphosphonates (BPs) are effective in the management of this condition. We have tested the hypothesis that BPs suppress apoptosis in these cell types. Etidronate, alendronate, pamidronate, olpadronate, or amino-olpadronate (IG9402, a bisphosphonate that lacks antiresorptive activity) at 10(-9) to 10(-6) M prevented apoptosis of murine osteocytic MLO-Y4 cells, whether it was induced by etoposide, TNF-alpha, or the synthetic glucocorticoid dexamethasone. BPs also inhibited apoptosis of primary murine osteoblastic cells isolated from calvaria. Similar antiapoptotic effects on MLO-Y4 and osteoblastic cells were seen with nanomolar concentrations of the peptide hormone calcitonin. The antiapoptotic effect of BPs and calcitonin was associated with a rapid increase in the phosphorylated fraction of extracellular signal regulated kinases (ERKs) and was blocked by specific inhibitors of ERK activation. Consistent with these in vitro results, alendronate abolished the increased prevalence of apoptosis in vertebral cancellous bone osteocytes and osteoblasts that follows prednisolone administration to mice. These results suggest that the therapeutic efficacy of BPs or calcitonin in diseases such as glucocorticoid-induced osteoporosis may be due, in part, to their ability to prevent osteocyte and osteoblast apoptosis.  (+info)

*Alendronic acid

After absorption in the bone, alendronate has an estimated terminal elimination half-life of 10 years. Alendronate inhibits ... the absorption of alendronate is decreased. At least half an hour should pass after intake of alendronate before taking the ... Bone: alendronate has been linked in long-term users to the development of low-impact femoral fractures. Further, studies ... Alendronate". Bioorg. Med. Chem. 4 (1): 3-4. doi:10.1016/0968-0896(96)00042-9. PMID 8689235. Black DM, Cummings SR, Karpf DB, ...

*Etidronic acid

For this reason, other bisphosphonates, like alendronate, are preferred when fighting osteoporosis. To prevent bone resorption ...

*DMOZ - Health: Pharmacy: Drugs and Medications: A: Alendronate

RxList: Alendronate Pharmacology, side effects, drug interactions, and other prescribing information for the osteoporosis ...

*Bisphosphonate

The bisphosphonate alendronate reduces the risk of hip, vertebral, and wrist fractures by 35-39%; zoledronate reduces the risk ... Heckbert SR, Li G, Cummings SR, Smith NL, Psaty BM (April 2008). "Use of alendronate and risk of incident atrial fibrillation ... Only in the 1990s was their actual mechanism of action demonstrated with the initial launch of Fosamax (alendronate) by Merck ... Wysowski D, Chang J (2005). "Alendronate and risedronate: reports of severe bone, joint, and muscle pain". Arch Intern Med. 165 ...

*Ibutamoren

Effect of alendronate and MK-677 (a growth hormone secretagogue), individually and in combination, on markers of bone turnover ... Murphy MG, Weiss S, McClung M, Schnitzer T, Cerchio K, Connor J, Krupa D, Gertz BJ; MK-677/Alendronate Study Group. ...

*Teriparatide

November 2007). "Teriparatide or alendronate in glucocorticoid-induced osteoporosis". The New England Journal of Medicine. 357 ...

*Hyper-IgD syndrome

"Weekly oral alendronate in mevalonate kinase deficiency". Orphanet Journal of Rare Diseases. 8: 196. doi:10.1186/1750-1172-8- ...

*Ghrelin

Işeri SO, Sener G, Yüksel M, Contuk G, Cetinel S, Gedik N, Yegen BC (December 2005). "Ghrelin against alendronate-induced ...

*Gideon Rodan

This compound became known as Alendronate or Fosamax. In further works he examined the role of steroid in bone metabolism and ...

*Effervescent tablet

Newcastle upon Tyne July 1971 "In Brief: Effervescent Alendronate". The Medical Letter. October 15, 2012. Baynes, T.S., ed. ( ...

*Hajdu-Cheney syndrome

Brand names include Actonel (risedronate/alendronate), made by Merck Pharmaceuticals. Other drugs include Pamidronate, made by ...

*Osteopenia

Commonly used drugs are bisphosphonates including alendronate, risedronate, and ibandronate; selective estrogen receptor ...

*Paget's disease of bone

Alendronate sodium is given as tablets once daily for six months; patients should wait at least 30 minutes after taking before ...

*Mouth ulcer

Common examples are alendronate (a bisphosphonate, commonly prescribed for osteoporosis), cytotoxic drugs (e.g. methotrexate, i ... a little known adverse effect of alendronate: review of the literature". Journal of Oral and Maxillofacial Surgery. 70 (4): 830 ...

*Avascular necrosis

CS1 maint: Extra text: authors list (link) Agarwala, S; Jain, D; Joshi, Vr; Sule, A (Mar 2005). "Efficacy of alendronate, a ...

*Merck & Co.

Alendronate reduces the risk of hip, vertebral, and wrist fractures by 35-39%. In December 2013, Merck agreed to pay a total of ... Fosamax (alendronate) is a bisphosphonate used for the treatment of post-menopausal osteoporosis and for the prevention of ... "Systematic review and meta-analysis of the efficacy and safety of alendronate and zoledronate for the treatment of ... the North American Menopause Society and the UK National Osteoporosis Guideline Group recommend alendronate and certain other ...

*Menopause

The bisphosphate drug alendronate may decrease the risk of a fracture, in women that have both bone loss and a previous ... Wells, GA; Cranney, A; Peterson, J; Boucher, M; Shea, B; Robinson, V; Coyle, D; Tugwell, P (Jan 23, 2008). "Alendronate for the ...

*Geranyltranstransferase

FPPS is the target of bisphosphonate drugs such as Fosamax (alendronate) and Actonel (risedronate). Bisphosphonate drugs are ...

*Osteosarcoma

Tomlin JL, Sturgeon C, Pead MJ, Muir P (29 July 2000). "Use of the bisphosphonate drug alendronate for palliative management of ... Some current studies indicate osteoclast inhibitors such as alendronate and pamidronate may have beneficial effects on the ...

*Abaloparatide

Combined abaloparatide and alendronate therapy reduced significantly the incidence of vertebral and nonvertebral fractures. A ... received additional 2 years of 70 mg of alendronate, Vitamin D (400 to 800 IU), and calcium (500-1000 mg) supplementation daily ... "Eighteen Months of Treatment With Subcutaneous Abaloparatide Followed by 6 Months of Treatment With Alendronate in ...

*Senile osteoporosis

Duque G; Rivas D (October 2007). "Alendronate has an anabolic effect on bone through the differentiation of mesenchymal stem ...

*Fibrous dysplasia of bone

... placebo-controlled trial of alendronate treatment for fibrous dysplasia of bone". The Journal of Clinical Endocrinology and ...

*Feline odontoclastic resorptive lesion

Use of alendronate has been studied to prevent TRs and decrease progression of existing lesions. True dental caries is uncommon ...

*Hematopoietic stem cell niche

Finally, osteoclast inhibition by the bisphosphonate alendronate has correlated with decreased HSCs and bone marrow engraftment ...

*Chest pain

Medication such as nonsteroidal anti-inflammatory drug (NSAIDs) and alendronate can induce oesophagitis if not swallowed ...
Keep alendronate sodium tablets and all medicines out of the reach of children. General information about the safe and effective use of alendronate sodium tablets . Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide. Do not use alendronate sodium tablets for a condition for which it was not prescribed. Do not give alendronate sodium tablets to other people, even if they have the same symptoms you have. It may harm them. This Medication Guide summarizes the most important information about alendronate sodium tablets. If you would like more information, talk with your doctor. You can ask your doctor or pharmacist for information about alendronate sodium tablets that is written for health professionals. For more information, call 1-800-272-5525. What are the ingredients in alendronate sodium tablets ? ...
We aimed to characterize incident users of alendronate from Denmark and Spain, and investigate their eligibility for participation in the pivotal Fracture Intervention Trial (FIT). This is an international cross-sectional study, where the data were obtained from the SIDIAP database (Sistema dInformació per al Desenvolupament de lInvestigació en Atenció Primària) from Catalonia (Spain) and the Danish Health Registries (DHR). This study included patients who were incident users of alendronate, ≥40 years old with no history of Pagets disease. Our measurements were the proportion of incident users of alendronate who were not eligible to participate in FIT. 14,316 and 21,221 subjects initiated alendronate in 2006-2007 (SIDIAP) and 2005-2006 (DHR), respectively. SIDIAP and DHR alendronate user cohorts had 2347 (16.4 %) and 5275 (24.9 %) subjects aged |80 years old, reported 9 (0.1 %) and 91 (0.4 %) diagnoses of myocardial infarction, 423 (3 %) and 368 (1.7 %) of erosive gastro-intestinal disease, 200
BACKGROUND: Preventing bone loss associated with menopause and aging and maintaining the normal micro-architecture of bone provide important opportunities for the prevention of osteoporosis and fractures. OBJECTIVE: To determine the safety and efficacy of alendronate, an aminobisphosphonate, for preventing postmenopausal bone loss. DESIGN: 3-year double-blind, randomized, placebo-controlled trial. SETTING: 15 osteoporosis centers throughout the world. PARTICIPANTS: 447 women who had recently experienced menopause (6 to 36 months before study entry). INTERVENTION: Participants were randomly assigned to one of five regimens: oral placebo; oral alendronate, 1, 5, or 10 mg/d; or oral alendronate, 20 mg/d for 2 years followed by placebo during the third year (20/0 mg/d). MEASUREMENTS: Bone mineral density was measured by dual-energy x-ray absorptiometry. Bone turnover and bone quality were assessed with biochemical markers and bone histomorphometry. RESULTS: Alendronate at 5, 10, and 20/0 mg/d increased bone
This is a randomized, prospective, open-label study in which osteoporotic postmenopausal women self-administer synthetic hPTH-(1-34), alendronate, or both, every day for 2.5 years. Participants initially come to Massachusetts General Hospital once a month, and subsequently once every 3-6 months, for measurements of serum and urine indices of bone formation and resorption, serum and urine toxicity tests, and DXA/QCT measurements of bone mass. One-third of the participants take hPTH-(1-34) daily, one-third take alendronate once daily, and one-third take both daily (Phase A, months 0-30).. Participants who complete Phase A are eligible for a 12 month extension study (Phase B, months 30-42), during which any alendronate treatment is continued without change and any hPTH 1-34 treatment is stopped.. Participants who complete Phase B are eligible for a second 12 month extension study (Phase C, months 42-54), during which any alendronate treatment is continued without change and every participant takes ...
The Effect of Alendronate on Fracture-Related Healthcare Utilization and Costs: The Fracture Intervention Trial. Chrischilles, E. A.; Dasbach, E. J.; Rubenstein, L. M.; Cook, J. R.; Tabor, H. K.; Black, D. M. // Osteoporosis International;Sep2001, Vol. 12 Issue 8, p654 The Vertebral Fracture Arm (VFA) of the Fracture Intervention Trial (FIT) study demonstrated that alendronate reduced the incidence of spine, forearm and hip fractures in women with low bone mass and existing vertebral fractures by about 50%. The objective of the present study was to determine... ...
This study will evaluate the bioequivalence of alendronate in combination with vitamin D compared to alendronate alone and the bioequivalence of vitamin D in combination with alendronate compared to vitamin D alone.. This was an open-label, randomized, 2-part, crossover study. Each participant participated in one part of the study only (i.e., each participant participated only in Part I or only in Part II). Participants entered the study sequentially within each part of the study. A washout of at least 12 days separated each treatment period within each part of the study. ...
UNLABELLED Once-weekly alendronate 70 mg and once-weekly risedronate 35 mg are indicated for the treatment of postmenopausal osteoporosis. These two agents were compared in a 12-month head-to-head trial. Greater gains in BMD and greater reductions in markers of bone turnover were seen with alendronate compared with risedronate with similar tolerability. INTRODUCTION The nitrogen-containing bisphosphonates, alendronate and risedronate, are available in once-weekly (OW) formulations for the treatment of postmenopausal osteoporosis. A 12-month, head-to-head study was performed to compare these agents in the treatment of postmenopausal women with low BMD. MATERIALS AND METHODS A total of 1053 patients from 78 U.S. sites were randomized to OW alendronate 70 mg (N = 520) or risedronate 35 mg (N = 533), taken in the morning after fasting. Endpoints included BMD changes over 6 and 12 months at the hip trochanter, total hip, femoral neck, and lumbar spine (LS); percent of patients with predefined levels of
A bisphosphonate derivative DTPA-bis(alendronate) conjugate has been synthesized and evaluated as potential radiopharmaceutical for bone imaging. The compound was synthesized by the covalent coupling of DTPA-bis(anhydride) with alendronate and was char-acterized on the basis of IR, NMR and mass spectroscopy. It was labelled with 99mTc with 96% efficacy and was found stable for about 24 h under physiological conditions. Blood kinetic studies of 99mTc DTPA-bis(alendronate) showed a biexponential pattern as well as quick washout from the blood circulation. The biological t1/2(F) and t1/2(S) were found to be 50 min ± 0.001 and 6 h 30 min ± 0.005, respectively. Imaging and biodistribution studies showed a significant accumulation of 99mTc DTPA-bis(alendronate) conjugate at bone site. Bone-to-muscles ratios were 12.08 ± 0.001 at 1 h, 45.33 ± 0.001 at 4 h and 35.83 ± 0.001 at 24 h after post-injection, respectively. The receptor binding of the 99mTc-DTPA-bis (alendronate) was established on human ...
Alendronate sodium hydrate (oral jelly) for the treatment of osteoporosis: review of a novel, easy to swallow formulation Kazuhiro Imai Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Tokyo, Japan Abstract: Osteoporosis is a skeletal disorder characterized by loss of bone mass, decreased bone strength, and an increased risk of bone fracture. The disease progresses with age, especially in postmenopausal women. Japan is one of the most rapidly aging societies worldwide. Japanese individuals over 65 years of age constituted 23.0% of the population in 2010 and 25.1% to 25.2% as of 2013. The estimated number of people with osteoporosis in Japan is currently 13 million. Bisphosphonates increase bone mineral density by inhibiting osteoclast-mediated bone resorption, thereby reducing the risk of fractures. Alendronate sodium hydrate (alendronate) is a bisphosphonate that potently inhibits bone resorption and is used to treat osteoporosis. Sufficient water is required
If you are using alendronate oral liquid, drink at least 2 ounces (a quarter of a cup) of water immediately after taking the medicine. This will allow the medicine to reach your intestines and be absorbed by the body more quickly. Swallow the tablet whole with a full glass (6 to 8 ounces) of plain water. Do not suck or chew on the tablet because it may cause throat irritation. If you are taking alendronate effervescent tablet, dissolve it in 4 ounces of room temperature plain water only (not mineral water or flavored water). Wait at least 5 minutes after the effervescence stops and then stir the solution for 10 seconds and drink it. Do not lie down for at least 30 minutes after taking alendronate and before having your first food for the day. This will help alendronate reach your stomach faster. It will also help prevent irritation to your esophagus. It is important that you eat a well-balanced diet with adequate amounts of calcium and vitamin D (found in milk or other dairy products). However, ...
Main / Thermometers / Alendronate oral dosage Usual Adult Dose for Osteoporosis. Treatment of Osteoporosis in Postmenopausal Women; To Increase Bone Mass in Men with Osteoporosis: 10 mg orally once a day or mg orally once a week. Treatment of Glucocorticoid-Induced Osteoporosis: 5 mg orally once a day or mg orally once a day in postmenopausal. Administration. Take only in morning, not at bedtime or before arising. Take tablet with full glass of water ( oz) at least 30 minutes before first food or drink of day, in upright position. Administer oral solution with at least 2 ounces of water. Swallow with plain water only; mineral water, coffee, juice or other beverages.. Alendronate (Fosamax, Binosto) is an oral drug used together to treat and prevent blood. Learn about side effects, warnings, dosage, and more.‎Side effects · ‎Interactions · ‎Other warnings · ‎Dosage. System AND ADMINISTRATION. Suppose alendronate tablets 5 mg, 10 mg, 35 mg, and 40 mg are alendronate oral dosage in the ...
Importance Oral glucocorticoid treatment increases fracture risk, and evidence is lacking regarding the efficacy of alendronate to protect against hip fracture in older patients using glucocorticoids.Objective To investigate whether alendronate treatment in older patients using oral prednisolone is associated with decreased hip fracture risk and adverse effects.Design, Setting, and Participants Retrospective cohort study using a national database (N = 433 195) of patients aged 65 years or older undergoing a health evaluation (baseline) at Swedish health care facilities; 1802 patients who were prescribed alendronate after at least 3 months of oral prednisolone treatment (≥5 mg/d) were identified. Propensity score matching was used to select 1802 patients without alendronate use from 6076 patients taking prednisolone with the same dose and treatment time criteria. Follow-up occurred between January 2008 and December 2014.Exposures Alendronate vs no alendronate use; no patients had previously ...
Main results. 18% of patients used PPIs at baseline, and 27% used PPIs concurrently with alendronate during follow-up. 5.4% of patients had hip fractures, 1.5% had forearm fractures, 0.9% had humerus fractures, and 0.6% had spine fractures. Concurrent use of PPIs was associated with reduced effectiveness of alendronate for preventing hip fractures compared with no PPI use (Table); PPI use did not attenuate the effectiveness of alendronate for preventing forearm (4.5/1000 patient-y in PPI users vs 4.3/1000 patient-y in nonusers), humerus (2.9 vs 2.5/1000 patient-y), or spine (2.7 vs 1.3/1000 patient-y) fractures. In patients who used PPIs concurrently with alendronate, reduction in risk for hip fractures attenuated in a dose-dependent manner and was maintained only at lower cumulative PPI doses (cumulative defined daily doses [DDDs] 1 to 359, n = 7210, hazard ratio [HR] 0.63, 95% CI 0.55 to 0.72; DDDs 360 to 719, n = 1701, HR 1.00, CI 0.70 to 1.45; DDDs ≥ 720, n = 1266, HR 1.24, CI 0.71 to ...
Atypical femur fracture: There is evidence that long term use of this class of medication may contribute to a type of rare fracture of the long bone in the thigh (femur).. If you experience new or unusual pain in the groin, hip, or thigh area, contact your doctor as soon as possible.. Bone, joint, and muscle problems: Rarely, people taking this medication experience severe bone, joint, or muscle pain. This is usually reversed when the medication is stopped.. Calcium and vitamin D: Calcium and vitamin D are important contributors to bone growth and strength. It may be necessary to take calcium or vitamin D supplements to get the best effect from alendronate if you are not getting enough from your diet. Your doctor may test you for low calcium levels or vitamin D deficiency before you start taking alendronate.. Effects on the esophagus: Alendronate may irritate the lining of the esophagus (the passage from the throat to the stomach). Esophagitis, ulcers, and erosions have been reported by people ...
Member of Farmavita.net is offering dossier in European CTD format for Alendronate sodium; 5/10/35/70 mg, tablets.. Dossier is registered in EU RMS.. License for the use of the Dossier is related to initial downpayment and commitment to bulk purchase of blisters. Alendronate sodium is classified as a medicine for osteoporosis, according to the ATC index. Offer is valid subject to confirmation, country by country. There will be no sales in those countries where this offer would constitute an infringement of third parties intellectual proprietary rights. Farmavita.Net is not owner of offered products/licenses and do not take any liability related to them. However, as the licensing agent we do our the best to facilitate that closed licensing agreements are made on mutual benefit of contracting parties and without infringement of intellectual property of third parties. ...
Alendronate Sodium Hainan is a medicine available in a number of countries worldwide. A list of US medications equivalent to Alendronate Sodium Hainan is available on the Drugs.com website.
Sandoz Alendronate: Alendronate belongs to a family of medications known as bisphosphonates. It is used to treat and prevent osteoporosis for postmenopausal women. It is also used to treat osteoporosis for men.
Effects of short-term combined treatment with alendronate and elcatonin on bone mineral density and bone turnover in postmenopausal women with osteoporosis Jun Iwamoto1, Mitsuyoshi Uzawa2, Yoshihiro Sato3, Tsuyoshi Takeda1, Hideo Matsumoto11Institute for Integrated Sports Medicine, Keio University School of Medicine, Tokyo, Japan; 2Department of Orthopaedic Surgery, Keiyu Orthopaedic Hospital, Gunma, Japan; 3Department of Neurology, Mitate Hospital, Fukuoka, Japan Abstract: The antiresorptive drug elcatonin (ECT) is known to relieve pain in postmenopausal women with osteoporosis. A prospective open-labeled trial was conducted to compare the effects of short-term combined treatment with alendronate (ALN) and ECT on bone mineral density (BMD) and bone turnover with those of single treatment with ALN in postmenopausal women with osteoporosis. Two hundred and five postmenopausal osteoporotic women (mean age: 70 years) were recruited in our outpatient clinic. Forty-six women with back pain were treated
In this Danish national register-based cohort study, we examined the effects of alendronate on the development of colon cancers and survival. The incidence of colon cancer and mortality rate, once colon cancer had been diagnosed, were lower in patients treated with alendronate, posing the question whether alendronate acts as chemopreventive.When bisphosphonates are given by mouth, around 99% remains non-absorbed in the intestine. Based on their biochemical actions, we predicted that oral bisphosphonates might prevent colon cancers.This is a Danish national register-based cohort study. We identified 30,606 women aged 50+, mean age 71.9 years, who had not previously taken treatments for osteoporosis, who began to take alendronate in 1996-2005, and assigned 124,424 individually age- and gender-matched control subjects. The main outcome measure was colorectal cancers incidence and post-diagnosis survival in patients taking oral alendronate for osteoporosis.Cox proportional hazards analysis of death due to
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Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice. ...
p,,strong,Background and Aim:,/strong, Chemotherapeutic agents are adjunctive substances for treatment of periodontitis through modulation of host response. Sodium alendronate is one of the medicaments which are used for this purpose. Since alkaline phosphates (ALP) level is an indicator for evaluation of bone metabolism changes, in this study the effect of sodium alendronate on periodontitis is investigated by measuring gingival crevicular fluid alkaline phosphates (GCF ALP) levels. ,/p,,p,,strong,Materials & Methods:,/strong, In this double-blind experimental study, 24 patients (12 males and 12 females between the agen of 35 to 50 years) with moderate chronic periodontitis have been evaluated. All patients received scaling and root planning. Sodium alendronate and placebo capsules were used weekly in a period of six months for case and control groups respectively samples were collected in first visit, 3 months, and 6 month later and analyzed with spectrophotometry. Periodontal assessments were ...
Alendronate is a bisphosphonate which prevent the osteoclast mediated bone resorption. Alendronate may decrease bone resorption and increase the density of the bone.
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Liberman UA, Weiss SR, Broll J, Minne HW, Quan H, Bell NH, Rodriguez-Portales J, Downs RW, Dequeker J, Favus M, Seeman E, Recker RR, Capizzi T, Santora AC, Lombardi A, Shah RV, Hirsch LJ, Karpf DB 1995 Effect of oral alendronate on bone mineral density and the incidence of fractures in postmenopausal osteoporosis. N Engl J Med 333: 1437-1443 ...
Alendronate is in the group of medicines called bisphosphonates (bis FOS fo nayts). It alters the cycle of bone formation and breakdown in the body. Alendronate slows bone loss while increasing bone mass, which may prevent bone fractures. Cholecalciferol is a form of vitamin D, and is important for the absorption of...
Patient Information FOSAMAX PLUS D (FOSS-ah-max PLUS D) (alendronate sodium/cholecalciferol) Tablets Read the patient information before you start taking FOSAMAX PLUS D 1. Also, read the leaflet each time
Consumer Medicine Information (CMI) about Fonat Plus (alendronate sodium and colecalciferol) intended for persons living in Australia.
Alendronate and cholecalciferol is used for the treatment of osteoporosis in men and postmenopausal women. This eMedTV article describes the effects of the drug and discusses possible off-label alendronate and cholecalciferol uses.
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DENVER -- Biochemical markers of bone turnover showed significantly faster responses on initiation of once-yearly zoledronic acid (Reclast) infusion than with weekly oral alendronate (Fosamax).
Alendronate (4-amino-1-hydroxybutylidene-1,1-bisphosphonate), an antiosteolytic agent, is currently under investigation in the treatment of a variety of bone diseases. Earlier studies from this laboratory have demonstrated that systemically administered alendronate is rapidly either taken up by bone tissues or excreted by the kidney, and that renal excretion is the only route of elimination. The purpose of this study is to characterize the renal handling of alendronate in rats by standard clearance procedures with inulin as a marker of glomerular filtration rate. Alendronate is highly bound to rat serum protein. The excretion of alendronate by the kidney is concentration-and dose-dependent, and saturable, indicating that it is secreted by an active transport mechanism. The secretory mechanism exhibits limitation of transport, with an apparent Tm of approximately 25 micrograms/min/kg. However, high doses of cimetidine, quinine, probenecid, and p-aminohippuric acid had no effect on the renal ...
European patent EP1175904B, Mercks patent relating to 70mg weekly alendronate, was declared as lacking inventive step over the prior art by the Opposition Division of the EPO at a hearing held on 17-18 March 2009. It was one of the largest oppositions to be held at the EPO after Merck had used a divisional application to recycle their initial patent on the weekly dosage (EP998292B) after it was revoked by the EPO Technical Board of Appeal in 2006. This patent has generated huge interest within the pharmaceutical industry and had already been the subject of litigation in several EU territories ...
It is important that you tell all of your health care providers that you are taking alendronate and cholecalciferol combination. If you are having a dental procedure while taking this medicine, you may have an increased chance of having a severe problem with your jaw. Make sure you tell your doctor about any new medical problems, especially with your teeth or jaws. Tell your doctor if you have severe bone, joint, or muscle pain while using this medicine. This medicine could lower the amount of calcium in your blood. Call your doctor right away if you develop any signs of low calcium levels, such as muscle spasms or twitching, or numbness or tingling in your fingers, toes, or lips. This medicine may increase your risk of developing fractures of the thigh bone. This may be more common if you use it for a long time. Check with your doctor right away if you have a dull or aching pain in the thighs, groin, or hips. Do not take other medicines unless they have been discussed with your doctor. This ...
Fibrous encapsulation can impair implant osseointegration and cause implant failure but currently there are limited strategies to address this problem. Since bisphosphonates (BPs), a class of drugs widely used to treat bone diseases, was recently found to induce fibroblast apoptosis, we hypothesize that by loading BPs on titanium (Ti) implant surface, fibrous encapsulation may be inhibited with simultaneous enhancement of implant osseointegration. This strategy of local administration can also be expected to minimize the adverse side effects of BPs, which are associated with intravenous injections. To verify this hypothesis, alendronate was loaded on Ti surface via a hydroxyapatite (CaP) coating, and the effects of the loaded alendronate on fibroblast proliferation and apoptosis, and osteoblast proliferation, alkaline phosphatase (ALP) activity, and apoptosis were investigated in vitro. With a surface density of loaded alendronate 0.046 mg/cm2 or higher, fibroblast proliferation was suppressed ...
School of Medicine. "By sharing the detailed results of efficacy and safety, we aim to help clinicians understand the future benefit:risk profile of romosozumab and its potential as a treatment option for postmenopausal women living with osteoporosis.". At primary analysis, postmenopausal women in the EVENITY treatment group experienced a statistically significant 19.0 percent relative reduction in the risk of non-vertebral fractures (8.7 percent versus 10.6 percent, respectively [p=0.04]). A 38.0 percent relative reduction in the risk of hip fractures was also observed (2.0 percent versus 3.2 percent, respectively [nominalp=0.015]), when compared to those receiving alendronate alone. Postmenopausal women who received EVENITY achieved greater gains in bone mineral density (BMD) from baseline at all measured sites and at all time points of the study versus those receiving alendronate alone. At month 12, the percentage change from baseline was greater with EVENITY versus alendronate at the lumbar ...
High-dose corticosteroids, used for many medical conditions, are associated with rapid bone loss from sites such as the vertebrae, and compression fractures can be observed within months. Recent trials suggest treatment with bisphosphonates or active vitamin D analogs can reduce bone loss and the risk of fracture associated with glucocorticoids, but few studies have directly compared such agents. We conducted a randomized, multicenter, open-label trial to compare the efficacy of alendronate, calcitriol, and simple vitamin D in prevention and treatment of glucocorticoid-induced bone loss. A total of 195 subjects (134 females and 61 males) commencing or already taking glucocorticoids were randomized to one of three groups: calcitriol, 0.5 to 0.75 microg/day; simple vitamin D (ergocalciferol, 30,000 IU weekly) plus calcium carbonate (600 mg daily); or alendronate, 10 mg/day plus calcium carbonate (600 mg daily). Over 2 years, mean lumbar bone mineral density change was +5.9% with alendronate, -0.5% with
Alendronic acid (INN) or alendronate sodium - sold as Fosamax by Merck - is a bisphosphonate drug used for osteoporosis, osteogenesis imperfecta, and several other bone diseases. It is marketed alone as well as in combination with vitamin D (2,800 IU and 5,600 IU, under the name Fosamax+D). Mercks U.S. patent on alendronate expired in 2008 and the drug is now available as a generic. It is the most widely prescribed bisphosphonate medicine in the United States . As with all potent bisphosphonates, the fraction of the drug that reaches the circulatory system intact (systemic bioavailability) after oral dosing is low, averaging only 0.6-0.7% in women and in men under fasting conditions. Intake together with meals and beverages other than water further reduces the bioavailability. The absorbed drug rapidly partitions, with approximately 50% binding to the exposed bone surface; the remainder is excreted unchanged by the kidneys. Unlike with most drugs, the strong negative charge on the two ...
Purpose: Combined treatment with alendronate and alfacalcidol is more beneficial to increase bone mineral density (BMD) than alendronate or alfacalcidol alone. decreased (?42.5% at 3 months and ?18.9% at 3 years) and the lumbar spine BMD but not the total hip BMD significantly increased (14.8% at 3 years) compared with the baseline values. However the incidence of vertebral and nonvertebral fractures was 26.5% and 2.9% respectively suggesting a high incidence of vertebral fractures. Conclusion: The outcomes of todays research suggest that mixed treatment with alendronate and alfacalcidol could be useful to decrease bone tissue turnover and raise the lumbar backbone BMD in individuals with severe bone tissue reduction and osteoporotic fracture. Its effectiveness MK-0752 against vertebral fractures appears never to end up being sufficient However. Thus anabolic real estate agents such as for example teriparatide ought to be taken into account as Edg3 first-line medicines in individuals with ...
4. Continue to take your tablets regularly for the correct length of time. Alendronate is generally prescribed long term so you need to be happy with the treatment. Although it is important that you take the medication as instructed, missing the odd week will probably not have an impact on your bone health in the long run but you should avoid this if you can. If you continually forget or struggle to take your medication it would be sensible to speak to your doctor about other treatment options that you may find easier to take.. Ask your doctor about how long you need to take your osteoporosis treatment. The current advice from the UK drug regulatory organisation (MHRA) is for a formal treatment review after about five years, primarily because of the potential (but rare) risk of atypical fractures (see our factsheet on atypical (unusual) thigh bone fracture for more information about this). At this review your doctor will make sure that the drugs are still needed, that they arent causing ...
Fosamax (Alendronate) drug is used to treat or prevent osteoporosis in women after menopause, can help to reduce the chance of having a spinal or hip fracture.
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Bisphosphonates have previously been demonstrated to inhibit squalene synthase, an enzyme in the cholesterol synthesis pathway that uses farnesyl diphosphate as a substrate (8) . Both farnesyl diphosphate and GGPP are important substrates in the prenylation of many G proteins involved in signal transduction pathways in cytoskeletal function and vesicular trafficking. The effects of alendronate treatment on osteoclasts can be partially rescued by geranylgeranyiol but not farnesol, indicating selectivity in their mechanism of action based on inhibition of protein isoprenylation (10) . We were unable to test this possibility as a mechanism for bisphosphonate activity on prostate cancer cell growth, since in our hands addition of 50 μm geranylgeranyiol alone caused significant cell detachment. 4. Several studies have presented evidence that the total net effect of bisphosphonate treatment in vivo may reflect their ability to disrupt or alter paracrine interactions in the bone microenvironment (13 , ...
March 17, 2004 Long-term use of alendronate continues to be protective against osteoporosis without causing harm, according to the results of a 10-year follow-up study published in the March 18 issue of the New England Journal of Medicine. The reduction in the risk of fracture during antiresorptive treatment has been related to the magnitude of changes in bone mineral density and remodeling activity, write Henry G. Bone, MD, from Michigan Bone and Mineral Clinic in Detroit, and colleagues from the Alendronate Phase III Osteoporosis Treatment Study Group. Alendronate, a potent inhibitor of bone resorption, has produced sustained reductions in biochemical markers of bone remodeling into the premenopausal range and consistent dose-related increases in bone mineral density in a variety of populations, including elderly women. In this multinational, double-blind study, postmenopausal women with osteoporosis were treated with alendronate for up to 10 years. The initial three-year phase of the ...
Osteoporosis is due to an imbalance of bone formation and resorption, and may lead to complications such as fractures. Diagnosis is typically made by measuring the T-score, which compares a patients bone mineral density with a young healthy person of the same sex. A T-score <-2.5 is diagnostic for having osteoporosis. Based on MKs T-score at the hip (-2.6), she is considered to have osteoporosis and should receive treatment to prevent fractures. The pharmacist should tell the patient that her alendronate should help to keep her bones strong, so that she would be less likely to get a fracture if she were to fall again. Alendronate prevents bone loss, and should be taken in addition to the calcium and vitamin D. MK should take alendronate in the morning with a full glass of water (~8 ounces) at least 30 minutes before eating, taking other medications, or drinking anything besides water, and should remain upright (either sitting or standing) for 30 minutes, not 2 hours. This is to prevent any ...
NJ Jury Rejects Plaintiffs Claims. WHITEHOUSE STATION, N.J., Feb. 14, 2011 - Merck & Co., Inc. today said a state court jury in New Jersey found in its favor in the Rosenberg v. Merck case, rejecting the claims of a woman who blamed her dental and jaw related problems on her FOSAMAX use. "We believe the evidence showed the company acted properly, and that FOSAMAX did not cause the plaintiffs dental and jaw problems," said Christy Jones of Butler, Snow, OMara, Stevens & Cannada PLLC, outside counsel for Merck. "Unfortunately, the plaintiff had medical conditions that can cause people to develop jaw and dental problems, regardless of whether they were taking FOSAMAX. She had an extensive history of periodontal and endodontic treatments and she took a number of powerful steroid medications that are known to suppress the bodys immune system and inhibit the bodys ability to heal." With todays verdict, Merck won the first state court case to go to trial in the coordinated N.J. FOSAMAX ...
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In an aging society, it can be foreseen that the incidence of diseases associated with undesired bone loss, such as metastatic bone disease, rheumatoid arthritis, osteoporosis, and periodontitis, will increase considerably. Thus, drugs specifically targeting osteoclasts and their activity are desirable, possibly as supplementary agents to existing therapies. Orally applicable Src inhibitors could be advantageous compared with the widely used bisphosphonates because the latter can cause complications in the upper gastrointestinal tract (15) or can lead to osteonecrosis of the jaw (16). Indeed, the Src inhibitor CGP76030 was shown to reduce the number of osteoclasts in rat tibiae more efficiently than the bisphosphonate alendronate (18). Little is known, however, of the effect of Src inhibitors on human osteoclasts. Here, we describe the effect of Src inhibitor AZD0530 on osteoclast formation and activity in the different models used (osteoblast/PBMC cocultures, PBMCs cultured at high density ...
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Elderly women with osteoporosis can significantly and safely improve their bone mass with a combination therapy of hormone replacement and the bisphosphonate alendronate (Fosamax).
Jennifer P. Schneider, MD, PhD reports a 59-year old previously healthy woman on long-term alendronate. While on a subway train in New York City one morning, the train jolted, and the woman shifted all her weight to one leg, felt a bone snap, and fell to the floor, suffering a spontaneous mid -femur fracture (see image). In the months following, it became clear that the fracture was not uniting. Schneider speculates that increased bone density from the bisphosphonate drug does not necessarily equate with good bone quality. By decreasing osteoclast activity and bone resorption, and therefore bone formation as well, microdamage, and brittle bone may result in fractures ...
Risedronate and even more notably alendronate use is linked to what are called atypical subtrochanteric fractures and femoral shaft fractures, both linked to bone insufficiency (Angthong and Angthong, 2011). More worrying is the fact that a longer duration of the biphosphonate treatment increases the odds of insufficiency fractures (Meier et al., 2012), which certainly raises concerns about how long the patients should be taking these drugs. Other side effects confirm that bone solidity does not necessarily reflect bone density. Dental practitioners should be aware of the increased risk of implant failure associated with oral biphosphonate use in the population (Yip et al., 2012). Practically speaking, it is well known that many dentists specializing in dental implants do not accept patients following these biphosphonate treatments due to the excessive risk of implant failure. Another concern lies in the association between biphosphonate use and jaw osteonecrosis (Arrain and Masud, 2011). ...
The case study is based on the experience of a 75 year woman who had a previous history using medications (Alendronate/Fosamax and Ibandronate/Boniva) to address bone loss and fracture risk. In her case, the use of both intravenous and oral bisphosphonate drugs did not result in increased bone density. In fact, the bone loss progressed despite the pharmacological intervention. Whats more, the oral forms of these medications were suspected of contributing to esophageal scarring which required two endoscopic procedures to remove.. After several failed attempts at using conventional drugs to address her bone loss, my client decided to experiment with an all-natural approach, which consisted of aerobic and resistance exercise, increased dietary protein and specific nutritional supplements. Her doctor was made aware of the changes she was making, but remained doubtful of everything but the supplemental calcium and Vitamin D. In essence, he was resigned that there wasnt much more they could do since ...
Pharmacology, side effects, drug interactions, and other prescribing information for the osteoporosis medication marketed as Fosamax. ...
Osteonecrosis of the jaw, commonly called ONJ, occurs when the jaw bone is exposed and begins to starve from a lack of blood. As the name indicates (osteo meaning bone and necrosis meaning death), the bone begins to weaken and die, which usually, but not always, causes pain. ONJ is associated with cancer treatments (including radiation), infection, steroid use, or potent antiresorptive therapies that help prevent the loss of bone mass. Examples of potent antiresorptive therapies include bisphosphonates such as alendronate (Fosamax); risedronate (Actonel and Atelvia); ibandronate (Boniva); and denosumab (Prolia). While ONJ is associated with these conditions, it also can occur without any identifiable risk factors.. ...
Visit your doctor or health care professional for regular checks ups. It may be some time before you see benefit from this medicine. Do not stop taking your medication except on your doctors advice. Your doctor or health care professional may order blood tests and other tests to see how you are doing.. You should make sure you get enough calcium and vitamin D while you are taking this medicine, unless your doctor tells you not to. Discuss the foods you eat and the vitamins you take with your health care professional.. Some people who take this medicine have severe bone, joint, and/or muscle pain. This medicine may also increase your risk for a broken thigh bone. Tell your doctor right away if you have pain in your upper leg or groin. Tell your doctor if you have any pain that does not go away or that gets worse.. This medicine can make you more sensitive to the sun. If you get a rash while taking this medicine, sunlight may cause the rash to get worse. Keep out of the sun. If you cannot avoid ...
Visit your doctor or health care professional for regular checks ups. It may be some time before you see benefit from this medicine. Do not stop taking your medicine except on your doctors advice. Your doctor or health care professional may order blood tests and other tests to see how you are doing.. You should make sure you get enough calcium and vitamin D while you are taking this medicine, unless your doctor tells you not to. Discuss the foods you eat and the vitamins you take with your health care professional.. Some people who take this medicine have severe bone, joint, and/or muscle pain. This medicine may also increase your risk for a broken thigh bone. Tell your doctor right away if you have pain in your upper leg or groin. Tell your doctor if you have any pain that does not go away or that gets worse.. This medicine can make you more sensitive to the sun. If you get a rash while taking this medicine, sunlight may cause the rash to get worse. Keep out of the sun. If you cannot avoid ...
This medication is typically used only once a week. However, your doctor or pharmacist may have suggested a different schedule that is more appropriate for you. Take it regularly and continuously to maintain its beneficial effects. Because it may cause esophageal irritation, this product must be swallowed with a large glass of water. Avoid lying down for at least 30 minutes after taking it. It is not advisable to split, chew or crush this medication since it may irritate your mouth and gastrointestinal tract. Important: Follow the instructions on the label. Do not use more of this product, or more often, than prescribed. This medication must be taken in the morning on an empty stomach, at least 30 minutes before eating. It must be taken with plain water only, even orange juice or coffee can decrease its absorption. To ensure effectiveness, avoid taking milk, dairy products, antacids or mineral supplements (calcium, iron, magnesium or zinc) for at least 30 minutes after taking this medication. ...
Visite a su médico o a su profesional de la salud para chequeos periódicos. Puede ser necesario que transcurra cierto tiempo antes de que pueda observar los beneficios de este medicamento. No deje de tomar su medicamento excepto si así lo indica su médico. Su médico o su profesional de la salud puede pedirle análisis de sangre u otros exámenes para chequear su evolución.. Asegurarse de que su dieta incluya la cantidad necesaria de calcio y vitamina D mientras esté tomando este medicamento. Hable con su profesional de la salud acerca de sus alimentos y las vitaminas que esté tomando.. Si tiene dolor al tragar, dificultad para tragar, acidez de estómago o dolor estomacal, comuníquese con su médico o su profesional de la salud inmediatamente.. Si está tomando un antiácido, suplemento mineral como calcio o hierro, o una vitamina con minerales espere por lo menos 30 minutos después de tomar este medicamento para tomarlos. No los tome a la misma vez.. Este medicamento puede aumentar la ...
Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, heartburn, anemia, blood clotting problems, ulcers or other stomach or bowel problems, sarcoidosis, a vitamin D deficiency, or a history of leukemia, lymphoma, or other cancer. Tell your doctor if you have dental problems or if you wear dentures. Also tell your doctor if you smoke or drink alcohol ...
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Fosamax is one of the leading prescription osteoporosis drugs. It contains alendronate, a compound that inhibits the breakdown of bones. However, Fosamax does nothing to build new bones. These effects on bone homeostasis can temporarily increase bone mineral density but eventually produce old, weak bones. Over the last 10 years, reports of adverse effects with Fosamax use have grown. One such side effect of Fosamax is the paradoxical increase in the risk of osteoporotic bone fractures in the thigh, hip and femur. But is bone fracture really a paradoxical side effect of Fosamax? Read on to find out why Fosamax is not only bad for your bones but also for your health.
Merck & Co says that it has won US Food and Drug Administration clearance for a new version of its osteoporosis treatment, Fosamax Plus D (alendronate sodium/cholecalciferol) - a once-weekly tablet containing Fosamax in combination with seven days worth of vitamin D. - News - PharmaTimes
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Alendronate belongs to a family of medications known as bisphosphonates. It is used to treat and prevent osteoporosis for postmenopausal women. It is also used to treat osteoporosis for men.
Fosamax (Alendronate) is used in men and women to treat or prevent osteoporosis that is caused by menopause or by taking steroids. Generic Fosamax slows bone loss while increasing bone mass, which ...
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養父 佐知子 , 小川 哲郎 , 中町 智哉 , 佐藤 和恵 , 清水 藍 , 松永 政司 , 塩田 清二 日本臨床生理学会雑誌 = Japanese journal of applied physiology 40(3), 137-143, 2010-06-01 参考文献28件 ...
The purpose of this study was to investigate the dose-response relationship of alendronate-impregnated allograft with respect to the amount of graft bone and the amount of new bone or total bone after 12 weeks in a goat bone chamber model. Also, the effects of adding DBM and the local application of antibiotics (cefazolin) were tested.. We showed a dose-response relation for local application of alendronate with respect to the amount of new bone as well as the amount of graft bone present in the bone chamber after 12 weeks. Decreased implant fixation has been observed with higher doses of bisphophonates (by blocking bone metabolism completely) [16]. Therefore, an optimum dose regarding bone resorption is essential, since it yields a positive balance between allograft resorption and the net amount of newly formed bone which results in improved fixation.. Our results show that with increasing alendronate concentration, graft resorption decreased and the amount of necrotic graft bone, left after 12 ...
Alendronate, risedronate, zoledronic acid, denosumab, and teriparatide reduce the risk of vertebral and nonvertebral fractures among postmenopausal women with osteoporosis. Ibandronate and raloxifene reduce the risk of vertebral but not nonvertebral fractures. Alendronate, risedronate, zoledronic acid, and denosumab prevent hip fractures among postmenopausal women with osteoporosis. Risedronate decreases the risk of vertebral and nonvertebral fracture among men with osteoporosis.. Among those treated with glucocorticoids, fracture risk reduction was demonstrated for risedronate and alendronate compared to placebo; and for teriparatide compared to alendronate.. Few studies have compared osteoporosis therapies head-to-head.. Adherence to pharmacotherapy is poor in patients with osteoporosis, as with other chronic conditions. Many factors affect adherence to medications, including dosing frequency, side effects of medications, knowledge about osteoporosis, and cost. Age, prior history of fracture, ...
[117 Pages Report] Check for Discount on Global Bisphosphonate Drugs Sales Market Report 2016 report by QYResearch Group. Notes: Sales, means the sales volume of Bisphosphonate Drugs Revenue,...
This trial has comapred the the serum levels of the bio- chemical bone resorption marker CTX-I collected before and after 25 days of antiresorptive drug
Transilial bone-biopsy specimens were available from the trial by McClung et al., which was a 3-year (1994 to 1997), double-blind, randomized, placebo-controlled, dose-ranging trial of alendronate in 447 healthy postmenopausal women 40 through 59 years of age who had entered menopause 6 to 36 months before enrollment.3 The trial by McClung et al. was a prevention trial, and the bone mineral density of the patients was within 2 SD above or below normal peak adult values at the initiation of the trial. However, the bone mineral density of the patients at baseline was approximately 10% below the mean value for young adult women, and the bone mineral density in patients receiving placebo decreased by 3 to 4% at the spine, femoral neck, and trochanter during the trial. This result indicates that these women were having postmenopausal bone loss.3 Women who had disorders of bone and mineral metabolism, smoked more than 20 cigarettes per day, or consumed three or more alcoholic drinks per day were ...
Transient increase of rat gastric amylin in the neonatal period and in experimental ulcers. Li, Zhanchun; Shi, Airong; Anders Karlsson, F. // Journal of Gastroenterology;2002, Vol. 37 Issue 3, p172 Background. Amylin (islet amyloid polypeptide; IAPP)-containing cells are present in the gastric mucosa and duodenum, but little is known about their regulation. In the present study, we investigated rat gastric mucosa in the neonatal period and in an experimental model of gastric ulcer.... ...
Octacalcium phosphate (OCP) interaction with alendronate (AL) solution results in the complete digestion of OCP: calcium ion is recruited by the bisphosphonate to yield quantitative precipitation of crystalline calcium alendronate monohydrate. This compound improves osteoblast differentiation and inhibits osteoclast proliferation and activity, both alone and, even more, in combination with OCP. ...
BACKGROUND CONTEXT Osteoporosis adversely affects disc degeneration cascades, and prophylactic alendronate (ALN) helps delay intervertebral disc degeneration (IDD) in ovariectomized (OVX) rats. However, there remains no information regarding whether ALN affects IDD with bone loss. PURPOSE This study aimed to observe the effects of ALN on degenerative discs with bone loss induced by OVX in rats. STUDY DESIGN This study used controlled in vivo experiments in rodents. METHODS Thirty female Sprague-Dawley rats were randomly assigned to undergo sham surgery (n=10) or OVX surgery (n=20); 3 months later, the OVX animals were injected with either ALN (OVX+ALN, 15 µg/kg/2w, n=10) or normal saline (OVX+vehicle treatment [V], n=10). At 3 months after the ALN intervention, van Gieson staining and immunohistochemistry were used to investigate histologic and metabolic changes in the discs. Bone mineral density (BMD), micro-computed tomography, and biomechanical tests were conducted to determine the biological
Two studies on alendronate (brand name Fosamax®) suggested a connection between alendronate and atrial fibrillation (1, 2). (Atrial fibrillation is a serious type of irregular heartbeat.) However, a number of other studies did not find a connection. These include a much larger Danish study (3) and other major research studies done in the past on many more thousands of women.. In 2007, the results of a major research study (4) suggested an increased possibility of atrial fibrillation in a small number of postmenopausal women given zoledronic acid (brand name Reclast®). The studys findings were not conclusive and after reviewing the research results, the Food and Drug Administration (FDA) approved zoledronic acid to treat osteoporosis in postmenopausal women. A second study (5) of this same medicine in older people with more medical problems did not show any increase in atrial fibrillation.. Atrial fibrillation is more commonly found in people 65 years and older, which is the age range of many ...
GREGORIO, Luiz Henrique de; LACATIVA, Paulo G. Sampaio; MELAZZI, Ana Cláudia C. and RUSSO, Luis Augusto Tavares. Glucocorticoid-induced osteoporosis. Arq Bras Endocrinol Metab [online]. 2006, vol.50, n.4, pp.793-801. ISSN 1677-9487. http://dx.doi.org/10.1590/S0004-27302006000400024.. Glucocorticoid-induced osteoporosis is the most frequent cause of secondary osteoporosis. Glucocorticoids cause a rapid bone loss in the first few months of use, but the most important effect of the drug is suppression of bone formation. The administration of oral glucocorticoid is associated with an increased risk of fractures at the spine and hip. The risk is related to the dose, but even small doses can increase the risk. Patients on glucocorticoid therapy lose more trabecular than cortical bone and the fractures are more frequent at the spine than at the hip. Calcium, vitamin D and activated forms of vitamin D can prevent bone loss and antiresorptive agents are effective for prevention and treatment of bone ...
Osteoporosis and low bone mass are currently estimated to be a major public health risk affecting |50% of the female population over the age of 50. Because of their bone-selective pharmacokinetics, nitrogen-containing bisphosphonates (N-BPs), currently used as clinical inhibitors of bone-resorption diseases, target osteoclast farnesyl pyrophosphate synthase (FPPS) and inhibit protein prenylation. FPPS, a key branchpoint of the mevalonate pathway, catalyzes the successive condensation of isopentenyl pyrophosphate with dimethylallyl pyrophosphate and geranyl pyrophosphate. To understand the molecular events involved in inhibition of FPPS by N-BPs, we used protein crystallography, enzyme kinetics, and isothermal titration calorimetry. We report here high-resolution x-ray structures of the human enzyme in complexes with risedronate and zoledronate, two of the leading N-BPs in clinical use. These agents bind to the dimethylallyl/geranyl pyrophosphate ligand pocket and induce a conformational change. The
The local renin-angiotensin system (RAS) is closely related to bone metabolism. However, it is unknown whether the local RAS is related to bone mineral density (BMD) in glucocorticoid-induced osteoporosis (GIOP). Here, we revealed that the two main characteristics of GIOP might inhibit bone formation and enhance bone resorption. INTRODUCTION: The aim of this study is to assess the expression of the main RAS components in the trabecular bone of lumbar vertebrae in GIOP and analyze the relationship between the major RAS components and BMD. METHODS: We collected 96 inpatient cases of lumbar disc herniation from patients who underwent dual-energy X-ray absorptiometry examinations followed by surgical treatment in our hospital. Patients were divided into the GIOP group (n = 48) and control group (n = 48). The circulating and local expression levels of the main RAS components were examined. The correlation between the main RAS components and BMD was then analyzed. RESULTS: The mRNA expression of local ...
Glucocorticoids, widely used in inflammatory disorders, rapidly increase bone fragility and, therefore, fracture risk. However, common bone densitometry measurements are not sensitive enough to detect these changes. Moreover, densitometry only partially recognizes treatment-induced fracture reductions in osteoporosis. Here, we tested whether the reference point indentation technique could detect bone tissue property changes early after glucocorticoid treatment initiation. After initial laboratory and bone density measurements, patients were allocated into groups receiving calcium+vitamin D (Ca+D) supplements or anti-osteoporotic drugs (risedronate, denosumab, teriparatide). Reference point indentation was performed on the cortical bone layer of the tibia by a handheld device measuring bone material strength index (BMSi). Bone mineral density was measured by dual-energy X-ray absorptiometry (DXA). Although Ca+D-treated patients exhibited substantial and significant deterioration, ...
... is a synthetic isoflavone derivative, which has been suggested to be an inhibitor of bone resorption and a stimulator of osteoblast activity in vitro in cell cultures and in vivo in experimental models of osteoporosis. Preliminary studies, mainly performed in Italy and Japan, suggested that ipriflavone (typical dosage 600 mg/day) is able to prevent bone loss, and some data even suggested that ipriflavone may increase bone mass in postmenopausal women. However, reports of lymphocytopenia in women taking ipriflavone generated concerns regarding the safety of this particular compound. In order to investigate the effect of oral ipriflavone in prevention of postmenopausal bone loss and to assess the safety profile of long-term treatment with ipriflavone in postmenopausal osteoporotic women, a prospective, randomized, placebo-controlled 4-year study was conducted in 474 postmenopausal white women with bone mineral densities below the threshold for a diagnosis of osteoporosis, according to ...
Actonel, Atelvia, Boniva, Fosamax, Reclast Carry Possible Fracture Risk. Oct. 13, 2010 - The bisphosphonate class of osteoporosis drugs - including Actonel, Atelvia, Boniva, Fosamax, Reclast, and generics - may raise the risk of thigh bone fracture, the FDA warns.. Theres no proof that the drugs cause the rare, serious thigh fractures called atypical femur fractures. But these events are more common in patients taking bisphosphonates than in patients taking other osteoporosis drugs.. For that reason, the FDA today issued a warning to patients. That warning will appear on the drugs labels.. It appears that the risk is related to use of bisphosphonates for longer than five years.. Patients who have these unusual fractures often report a dull ache in their thigh or groin in the weeks or months preceding the actual fracture.. That pain may be the only warning. These atypical fractures occur almost by themselves, with little or no reported trauma to the thigh.. Its possible for these fractures to ...

Alendronate (Oral Route) Before Using - Mayo ClinicAlendronate (Oral Route) Before Using - Mayo Clinic

Information about this alendronate-oral-route. Pregnancy Category. Explanation. All Trimesters. C. Animal studies have shown an ... Alendronate may make these conditions worse. Proper Use. This medicine comes with a Medication Guide and a patient information ... Alendronate is used to prevent and treat osteoporosis (thinning of the bone) in women after menopause. This medicine may also ... Use of alendronate is not indicated in children. Geriatric Appropriate studies performed to date have not demonstrated ...
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Alendronate may also be used to treat and prevent steroid-induced osteoporosis for men and women (osteoporosis caused by taking ... Alendronate belongs to a family of medications known as bisphosphonates. It is used to treat and prevent osteoporosis for ... Alendronate® by Sorres is no longer being manufactured for sale in Canada. For brands that may still be available, search under ... Alendronate increases the thickness of bone (bone mineral density) by slowing down the cells that usually break down bone ( ...
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Alendronate sodium hydrate (alendronate) is a bisphosphonate that potently inhibits bone resorption and is used to treat ... Once-weekly alendronate oral jelly was approved in 2012 by the Ministry of Health, Labour, and Welfare of Japan as the worlds ... In this review, this new formulation of alendronate sodium hydrate (oral jelly) is introduced and discussed in terms of ... Sufficient water is required to take an alendronate oral tablet; insufficient water could result in digestive system diseases, ...
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Proton-pump inhibitors were associated with reduced effectiveness of alendronate for preventing hip fractures | Annals of...Proton-pump inhibitors were associated with reduced effectiveness of alendronate for preventing hip fractures | Annals of...

18% of patients used PPIs at baseline, and 27% used PPIs concurrently with alendronate during follow-up. 5.4% of patients had ... Proton-pump inhibitors were associated with reduced effectiveness of alendronate for preventing hip fractures Kouta Ito, MD, MS ... 38 088 patients ≥ 35 years of age (mean age 70 y, 83% women) who started alendronate between 1996 and 2005 (index date = date ... In patients who used PPIs concurrently with alendronate, reduction in risk for hip fractures attenuated in a dose-dependent ...
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These highlights do not include all the information needed to use ALENDRONATE SODIUM TABLETS safely and effectively. See full...These highlights do not include all the information needed to use ALENDRONATE SODIUM TABLETS safely and effectively. See full...

Alendronate sodium tablets work only if taken on an empty stomach. * Take alendronate sodium tablets, after you get up for the ... Keep alendronate sodium tablets in a tightly closed container. Keep alendronate sodium tablets and all medicines out of the ... Alendronate Sodium Tablets, USP (al-LEN-droe-nate SO-dee-uhm) Read the Medication Guide that comes with alendronate sodium ... What should I tell my doctor before taking alendronate sodium tablets ? Before you start alendronate sodium tablets , be sure ...
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... By Meztilrajas. 08.08.2017. Main / Thermometers / Alendronate oral dosage Usual Adult Dose for ... Suppose alendronate tablets 5 mg, 10 mg, 35 mg, and 40 mg are alendronate oral dosage in the marketplace, FOSAMAX is no ... Find trematode medical information for Alendronate Oral on WebMD alendronate oral dosage its uses, side effects and tendon, ... Alendronate (Fosamax, Binosto) is an oral drug used together to treat and prevent blood. Learn about side effects, warnings, ...
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Patente US7192938 - Method of treatment using bisphosphonic acid - Google PatentesPatente US7192938 - Method of treatment using bisphosphonic acid - Google Patentes

Oral liquid alendronate formulations. US5488041. 4 Abr 1994. 30 Ene 1996. Sanofi. Method of promoting bone repair using ... In animal models of bone resorption, ibandronate is 2, 10, 50 and 500 times more potent than risedronate, alendronate, ... The preferred bisphosphonic acid or pharmaceutically acceptable salt is selected from the group consisting of alendronate, ... Composition and dosage form for delayed gastric release of alendronate and/or other bis-phosphonates. ...
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A list of US medications equivalent to Alendronate Sodium is available on the Drugs.com website. ... Alendronate Sodium is a medicine available in a number of countries worldwide. ... Ingredient matches for Alendronate Sodium. Alendronate. Alendronate Sodium (USAN) is known as Alendronate in the US. ... Alendronate Sodium. Alendronate Sodium may be available in the countries listed below. ...
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A list of US medications equivalent to Alendronate Sodium Hainan is available on the Drugs.com website. ... Alendronate Sodium Hainan is a medicine available in a number of countries worldwide. ... Alendronate. Alendronic Acid sodium monohydrate (a derivative of Alendronic Acid) is reported as an ingredient of Alendronate ... Alendronate Sodium Hainan may be available in the countries listed below.. Ingredient matches for Alendronate Sodium Hainan. ...
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Alendronate Osteoporosis Study - Full Text View - ClinicalTrials.govAlendronate Osteoporosis Study - Full Text View - ClinicalTrials.gov

Alendronate Osteoporosis Study. The safety and scientific validity of this study is the responsibility of the study sponsor and ... Drug Information available for: Alendronate sodium Genetic and Rare Diseases Information Center resources: Dermatomyositis ... Double-Blinded Controlled Trial of Alendronate for the Treatment of Childhood and Adolescent Glucocorticoid- Associated ... treatment of glucocorticoid-associated osteopenia and osteoporosis with 18 months of alendronate (FOSAMAX®, Merck & Co., Inc.) ...
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Alendronate in Juvenile Osteoporosis. The safety and scientific validity of this study is the responsibility of the study ... Participants who have completed our earlier phase-1 and II study on alendronate in juvenile osteoporosis will be invited in ... Participants who earlier completed our phase I or phase II study on alendronate in juvenile osteoporosis, were invited to ... Participants who completed our earlier phase I/II study on alendronate in juvenile osteoporosis were invited to participate in ...
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Alendronate sodium/colecalciferol) intended for persons living in Australia. ... Alendronate not only helps prevent the loss of bone but actually helps to rebuild bone and make bone less likely to fracture. ... The alendronate in DRONALEN PLUS works by slowing down the process of old bone being removed, which allows the bone-forming ... In addition to alendronate, DRONALEN PLUS also contains vitamin D, an essential nutrient required for calcium absorption and ...
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Information about this alendronate-and-cholecalciferol-oral-route. Pregnancy Category. Explanation. All Trimesters. C. Animal ... Use of alendronate and cholecalciferol combination is not indicated in children. Geriatric Appropriate studies performed to ... Alendronate and cholecalciferol combination is used to treat osteoporosis (thinning of the bone) in women after menopause. This ... It is important that you tell all of your health care providers that you are taking alendronate and cholecalciferol combination ...
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After six weeks, the zoledronic acid group averaged 26 ng/mL whereas the mean among patients taking alendronate was 37 ng/mL (P ... She noted that the biomarkers were "already highly suppressed" in the alendronate group at the six-week mark. "Im actually ... Source Reference: Hadji P, et al "The Rapid Onset and Sustained Efficacy (ROSE) study: zoledronic acid vs alendronate -- first ... She also said that, in and of themselves, the results werent a reason to prefer zoledronic acid over alendronate. ...
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Fosamax (Alendronate) - Side Effects, Dosage, Interactions - DrugsFosamax (Alendronate) - Side Effects, Dosage, Interactions - Drugs

Alendronate) drug is used to treat or prevent osteoporosis in women after menopause, can help to reduce the chance of having a ... A: Alendronate (Fosamax) belongs to the group of drugs known as a bisphosphonates. Alendronate is used for the prevention and ... Fosamax Plus D (alendronate cholecalciferol), a single once weekly tablet containing 70 mg Fosamax (alendronate) and 2,800 IU ... In general, do not take an alendronate tablet if you cannot sit upright or stand for at least 30 minutes. Alendronate can cause ...
more infohttps://www.everydayhealth.com/drugs/fosamax

Fonat Plus (alendronate sodium and colecalciferol) Drug / Medicine InformationFonat Plus (alendronate sodium and colecalciferol) Drug / Medicine Information

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more infohttps://www.news-medical.net/drugs/Fonat-Plus.aspx

Alendronate-70 - Uses, Side Effects, Interactions - MedBroadcast.comAlendronate-70 - Uses, Side Effects, Interactions - MedBroadcast.com

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more infohttps://medbroadcast.com/drug/getdrug/alendronate-70

Auro-Alendronate - Uses, Side Effects, Interactions - MedBroadcast.comAuro-Alendronate - Uses, Side Effects, Interactions - MedBroadcast.com

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Osteofos (Alendronic Acid (Alendronate Sodium)) CiplaOsteofos (Alendronic Acid (Alendronate Sodium)) Cipla

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Alendronate SodiumAlendronate Sodium

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more infohttp://healthboard.com/Encyclopedia/Health/term/alendronate_sodium.html

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Apo-Alendronate (Alendronic Acid (Alendronate Sodium)) ApotexApo-Alendronate (Alendronic Acid (Alendronate Sodium)) Apotex

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Teriparatide Found Superior to Alendronate in Steroid-Induced Osteoporosis | Medpage TodayTeriparatide Found Superior to Alendronate in Steroid-Induced Osteoporosis | Medpage Today

... twice as much as oral alendronate (Fosamax) did in a head-to-head comparison ... In the randomized, double-blind trial, 428 patients were assigned to either 20 mcg of teriparatide or 10 mg of oral alendronate ... Teriparatide increased hip BMD by 3.8% while it rose 2.4% in the alendronate group. The advantage for teriparatide was ... Twice as many patients on teriparatide as on alendronate did not complete the planned therapy because of adverse effects. ...
more infohttps://www.medpagetoday.com/endocrinology/osteoporosis/7395
  • Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of alendronate in the elderly. (mayoclinic.org)
  • I feel like to remind that ALENDRONATE has remove the service tax from Clinical Research in the paper would have been diagnosed with Osteoporosis 6 years ago and have been recalcitrant, with Merck winning 2 cases, losing 2 and receiving a split biochemistry on a daily basis, and they all are abusers. (wanadoo.es)
  • A Merck spokeswoman said that ALENDRONATE has no effect against preventing unpaid dribbling of bone legislator, membership benefit of defiled threonine. (wanadoo.es)
  • Alendronate may also be used to treat and prevent steroid-induced osteoporosis for men and women (osteoporosis caused by taking corticosteroids such as prednisone for long periods of time). (medbroadcast.com)
  • The recommended dosage is one 70 mg alendronate /2800 international units vitamin D 3 or one 70 mg alendronate/5600 international units vitamin D 3 tablet once weekly. (rxlist.com)
  • But while pyrophosphate inhibits both osteoclastic bone resorption and the mineralization of the bone newly formed by osteoblasts, alendronate specifically inhibits bone resorption without any effect on mineralization at pharmacologically achievable doses. (wikipedia.org)
  • In addition to alendronate, DRONALEN PLUS also contains vitamin D, an essential nutrient required for calcium absorption and healthy bones. (news-medical.net)
  • After absorption in the bone, alendronate has an estimated terminal elimination half-life of 10 years. (wikipedia.org)
  • CBI wrote: Calcium/Magnesium supplements with Vitamin YouTube is made by Mission Pharmacal Co. I hark that Alendronate ALENDRONATE has been found in the tarsus of inbound mistreatment. (wanadoo.es)
  • Participants who earlier completed in our open labeled or double blind study of alendronate treatment for juvenile osteoporosis, were invited for one clinical visit. (clinicaltrials.gov)
  • However, treatment discontinuation because of adverse events was substantially more common in the alendronate group (10% versus 1%, P not reported). (medpagetoday.com)
  • Teriparatide has an estimated annual treatment cost of nearly $7,000, about eight times as much as for alendronate. (medpagetoday.com)
  • ALENDRONATE (a LEN droe nate) slows calcium loss from bones. (aarp.org)
  • For brands that may still be available, search under alendronate. (pharmasave.com)
  • Frye said ALENDRONATE does not differentiate stalked symptoms and cost, suggests new dolly. (wanadoo.es)
  • She noted that the biomarkers were "already highly suppressed" in the alendronate group at the six-week mark. (medpagetoday.com)
  • Teriparatide increased hip BMD by 3.8% while it rose 2.4% in the alendronate group. (medpagetoday.com)
  • Participants earlier were treated with alendronate for 12 months either in an open label study (without control) or double blind study with placebo control. (clinicaltrials.gov)
  • ALENDRONATE cloyingly lancinating that coltsfoot was physiologically only endogamic to post-menopausal women. (wanadoo.es)
  • Chromophore, which is inaccurately equal to alendronate as a bone-builder, and research suggests it mutely protects against guile molluscum and even moveable decline for women past symmetry. (wanadoo.es)
  • This leaflet answers some common questions about alendronate. (nps.org.au)
  • Wonderful news and if leftmost arms of alendronate for 3 organismal hegemony cordially an initial 5 serpent ballgame ripening unsatisfying BMD at the end we're working for the update. (wanadoo.es)
  • The alendronate in DRONALEN PLUS works by slowing down the process of old bone being removed, which allows the bone-forming cells time to rebuild normal bone. (news-medical.net)
  • Under therapy, normal bone tissue develops, and alendronate is deposited in the bone-matrix in a pharmacologically inactive form. (wikipedia.org)
  • The name of your medicine is APO-Alendronate Once Weekly. (nps.org.au)
  • An endocrinology consultation was sought, and alendronate therapy was stopped. (hindawi.com)
  • Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of alendronate in the elderly. (mayoclinic.org)