Aldrin: A highly poisonous substance that was formerly used as an insecticide. The manufacture and use has been discontinued in the U.S. (From Merck Index, 11th ed)Dieldrin: An organochlorine insecticide whose use has been cancelled or suspended in the United States. It has been used to control locusts, tropical disease vectors, in termite control by direct soil injection, and non-food seed and plant treatment. (From HSDB)Heptachlor: A man-made compound previously used to control termites and other insects. Even though production of heptachlor was phased out of use in the United States during the late 1980's it remains in soil and hazardous waste sites. It is clearly toxic to animals and humans but, the International Agency for Research on Cancer (IARC) has determined that heptachlor is not classifiable as to its carcinogenicity to humans. (From ATSDR Public Heath Statement, April 1989)Endrin: An organochlorine compound that was formerly used as an insecticide. Its manufacture and use has been discontinued in the United States. (From Merck Index, 11th ed)Hydrocarbons, Chlorinated: Hydrocarbon compounds with one or more of the hydrogens replaced by CHLORINE.Chlordan: A highly poisonous organochlorine insecticide. The EPA has cancelled registrations of pesticides containing this compound with the exception of its use through subsurface ground insertion for termite control and the dipping of roots or tops of non-food plants. (From Merck Index, 11th ed)Pesticide Residues: Pesticides or their breakdown products remaining in the environment following their normal use or accidental contamination.Insecticides: Pesticides designed to control insects that are harmful to man. The insects may be directly harmful, as those acting as disease vectors, or indirectly harmful, as destroyers of crops, food products, or textile fabrics.Benzopyrene Hydroxylase: A drug-metabolizing, cytochrome P-448 (P-450) enzyme which catalyzes the hydroxylation of benzopyrene to 3-hydroxybenzopyrene in the presence of reduced flavoprotein and molecular oxygen. Also acts on certain anthracene derivatives. An aspect of EC An organochlorine insecticide that has been used as a pediculicide and a scabicide. It has been shown to cause cancer.

Abnormalities in the microsomal oxidases of the WHO standard reference strain of Musca domestica. (1/19)

Observations made during biochemical and toxicological studies of the housefly, in which the WHO standard reference (SR) strain was used as a standard, indicated that this strain differs from other strains in certain physiological and toxicological aspects. Experiments are described in which microsomal oxidases prepared from the standard reference strain and several other housefly strains, both susceptible and resistant to insecticides, were compared for heat stability, sensitivity to ionic strength, pH optima, and the spectral characteristics of their cytochrome P-450. In a comparison with 8 strains the SR strain microsomes were more stable at high incubation temperatures (40-47.5 degrees C). Compared to two other strains (NAIDM, susceptible, and Isolan-B, resistant) SR was more stable at low pH and more sensitive to high ionic strength. In spectral comparisons with NAIDM and Isolan-B, SR was found to contain microsomal cytochrome P-450 that differed slightly in its carbon monoxide or octylamine binding spectra. The results suggest that this strain may not provide a suitable reference in studies involving the microsomal oxidases. However, these apparent differences should not reduce the value of the SR stain as a reference in insecticide resistance studies.  (+info)

Aldrin and dieldrin: a review of research on their production, environmental deposition and fate, bioaccumulation, toxicology, and epidemiology in the United States. (2/19)

In the last decade four international agreements have focused on a group of chemical substances known as persistent organic pollutants (POPs). Global agreement on the reduction and eventual elimination of these substances by banning their production and trade is a long-term goal. Negotiations for these agreements have focused on the need to correlate data from scientists working on soil and water sampling and air pollution monitoring. Toxicologists and epidemiologists have focused on wildlife and human health effects and understanding patterns of disease requires better access to these data. In the last 20 years, substantial databases have been created and now are becoming available on the Internet. This review is a detailed examination of 2 of the 12 POPs, aldrin and dieldrin, and how scientific groups identify and measure their effects. It draws on research findings from a variety of environmental monitoring networks in the United States. An overview of the ecologic and health effects of aldrin and dieldrin provides examples of how to streamline some of the programs and improve access to mutually useful scientific data. The research groups are located in many government departments, universities, and private organizations. Identifying databases can provide an "information accelerator" useful to a larger audience and can help build better plant and animal research models across scientific fields.  (+info)

Normal-phase high-performance liquid chromatographic determination and identification of aldrin, dieldrin, and DDTs in eggs. (3/19)

A method for the routine monitoring of residual aldrin, dieldrin, pp'-DDT, op'-DDT, pp'-DDE, and pp'-DDD in eggs by high-performance liquid chromatography (HPLC) with a photo-diode array (PDA) detector is described. The lipids extracted from a whole egg are cleaned by a solid-phase extraction (SPE) ISOLUTE NH2 column with a diethyl ether-hexane (5:95, v/v) eluent. The HPLC separation is carried out using a normal-phase (LiChrosorb NH2) column, a heptane-hexane eluent (97:3, v/v), and a PDA detector. The average recoveries from fortified target compounds (0.1, 0.2, 0.3, and 0.4 microg/g, respectively) are > or = 83%, with standard deviations (SDs) between 2 and 5%. The interassay variabilities and their SDs are < or = 4.8% and < or =0.7%, with intra-assay variabilities of 2.1-3.3%. The limits of determination for these compounds range from 0.04 to 0.08 microg/g.  (+info)

Aldrin-induced locomotor activity: possible involvement of the central GABAergic-cholinergic-dopaminergic interaction. (4/19)

Aldrin (5 mg/kg/day, p.o.) under nontolerant condition, administered either for a single day or for 12 consecutive days, enhanced locomotor activity (LA) of rats. The increase in LA was greater in rats treated with aldrin for 12 consecutive days than that observed with a single dose. The aim of the present study is to evaluate the involvement of possible interactions of central GABAergic, cholinergic and dopaminergic systems using their agonist(s) and antagonist(s) in the regulation of LA in aldrin nontolerant rats. Administration of either L-DOPA along with carbidopa or bicuculline potentiated aldrin-induced increase in LA under nontolerant condition as well as LA of the control rats. Treatment with muscimol, haloperidol, atropine or physostigmine all decreased the LA of both aldrin nontolerant and control rats. Further, the application of (a) haloperidol along with bicuculline, atropine or physostigmine and (b) physostigmine along with bicuculline or L-DOPA + carbidopa significantly reduced LA but L-DOPA + carbidopa along with atropine or bicuculline increased LA of the control rats. These agonist(s)/antagonist(s)-induced decrease or increase in LA of the control rats were attenuated or potentiated, respectively, when those agonist(s)/antagonist(s) under abovementioned condition were administered to aldrin nontolerant rats. The attenuating or potentiating effects of aldrin on agonist(s)/antagonist(s) (either individually or in different combinations)-induced change in LA were greater in rats treated with aldrin for 12 consecutive days than that observed with a single-dose aldrin treatment. These results suggest that aldrin, under nontolerant condition, reduces central GABAergic activity and increases LA by activating dopaminergic system via inhibition of cholinergic activity. The treatment with aldrin for 12 consecutive days produces greater effect than that caused by a single-day treatment.  (+info)

Brain regional gamma-aminobutyric acid (GABA) and locomotor activity: effect of long-term aldrin exposure. (5/19)

Aldrin-induced stimulation of locomotor activity (LA) under nontolerant conditions was restored to control value after 20 or more consecutive days of aldrin administration. In contrast to the inhibition of GABAergic activity with aldrin under short-term conditions as observed in our previous study, the measurement of steady-state level of GABA, the activities of its metabolizing enzymes, turnover and the specific binding of GABA to its receptor in different regions of the brain of rats treated with aldrin (2 or 5 mg/kg/day, po) under long-term (for 30 consecutive days) conditions showed no change in the GABAergic activity in any regions of the rat brain. Moreover, the studies of the interaction between neurotransmitters (using agonist(s) and antagonist(s) of the respective neurotransmitter receptors) showed that long-term administration of aldrin restored the LA to control value by upregulation of central GABAergic activity through the interaction with dopaminergic and cholinergic systems. Thus, this result suggests that long-term aldrin exposure upregulated the central GABAergic activity inhibition under short-term aldrin treatment which may be a cause of restoration of LA stimulated by the short-term aldrin administration to its control value.  (+info)

Studies on photochemical reactions of air pollutants. XV. Photoreactivity of heptachloro-3'-cyclopentenyldioxy heptachloro-2-cyclopentene formed by exposure of hexachlorocyclopentadiene to ultraviolet light in air. (6/19)

Hexachlorocyclopentadiene (HCCP, 1), one of the starting materials in the synthesis of aldrin (3), was found to be able to epoxidize aldrin (3) to give dieldrin (4) when exposed to artificial light at wavelengths longer than 290 nm. In this photochemical reaction, heptachloro-3'-cyclopentenyldioxy heptachloro-2-cyclopentene (2) was isolated as a key intermediate, which appears to be derived from the interaction between the triplet state of photo-excited HCCP (1) and triplet oxygen (3sigma(g)-), but not from that between the ground state of HCCP (1) and singlet oxygen (1delta(g)). The peroxide (2) plays an important role in the formation of dieldrin (4), because it utilized oxygen atom derived from oxygen in air for the epoxidation.  (+info)

Comparative biodegradation of alkyl halide insecticides by the white rot fungus, Phanerochaete chrysosporium (BKM-F-1767). (7/19)

The ability of Phanerochaete chrysosporium to degrade six alkyl halide insecticides (aldrin, dieldrin, heptachlor, chlordane, lindane, and mirex) in liquid and soil-corncob matrices was compared by using 14C-labeled compounds. Of these, only [14C]lindane and [14C]chlordane underwent extensive biodegradation, as evidenced by the fact that 9.4 to 23.4% of these compounds were degraded to 14CO2 in 30 days in liquid cultures and 60 days in soil-corncob cultures inoculated with P. chrysosporium. Although [14C]aldrin, [14C]dieldrin, [14C]heptachlor, and [14D]mirex were poorly mineralized, substantial bioconversion occurred, as determined by substrate disappearance and metabolite formation. Nonbiological disappearance was observed only with chlordane and heptachlor.  (+info)

Occupational exposure to organochlorine insecticides and cancer incidence in the Agricultural Health Study. (8/19)

Organochlorine (OC) insecticides have been regulated as possible human carcinogens primarily on the basis of animal studies. However, the epidemiologic evidence is inconsistent. We investigated the relationship between cancer incidence and OC insecticide use among pesticide applicators enrolled in the Agricultural Health Study, a prospective cohort study of 57,311 licensed applicators in Iowa and North Carolina enrolled between 1993 and 1997. Information on ever use of 7 OC insecticides (aldrin, chlordane, DDT, dieldrin, heptachlor, lindane, toxaphene) was collected from a self-administered questionnaire at enrollment. Lifetime exposure-days to OC insecticides were calculated using additional data from a take-home questionnaire completed by 25,291 participants (44% of total). We found no clear evidence of an association between use of OC insecticides and incident cancers (N = 1,150) ascertained through December, 2002. When we focused on individual insecticides and structurally similar groups (aldrin and dieldrin; chlordane and heptachlor), significantly increased relative risks of some cancers were observed for use of some chemicals (rectal cancer and chlordane, lung cancer and dieldrin, non-Hodgkin lymphoma (NHL) and lindane, melanoma and toxaphene, leukemia and chlordane/heptachlor). Some significant decreased relative risks were also observed (colon cancer and aldrin; overall cancer and heptachlor). In conclusion, we did not observe any clear relationship between cancer risk and the use of OC insecticides. Our chemical-specific findings are based on small numbers and multiple comparisons, and should be interpreted with caution; however, some observed associations (lindane and NHL, chlordane/heptachlor and leukemia) are supported by previous evidence.  (+info)

  • This currently proposed revision is intended to correct errors that were discovered in the 2016 cleanup standards for three substances: aldrin, beryllium, and cadmium. (
  • On December 12, 2017, Pennsylvania's Environmental Quality Board (EQB) unanimously approved a final-omitted rulemaking to substantially increase the Act 2 cleanup standards for beryllium, cadmium, and aldrin. (
  • Buzz Aldrin photographed in Rio de Janeiro, Brazil in 2016. (
  • This currently proposed revision is intended to correct errors that were discovered in the 2016 cleanup standards for three substances: aldrin, beryllium, and cadmium. (
  • I support a return, but not for NASA, for every other country," Aldrin said Xinhua at the recent meeting of the Association of Space Explorers in Beijing. (
  • Since retiring from NASA and the U.S. Air Force, Aldrin refers to himself as a Global Statesman for Space, remaining a tireless advocate for human space exploration. (
  • Col. Aldrin responded this month with a lawsuit, accusing Andrew Aldrin and his business manager of recent years, Christina Korp, of elder exploitation, unjust enrichment and of converting his property for themselves. (
  • The name stuck, and he has since legally changed him name to "Buzz Aldrin," said moderator Christina Korp. (
  • Upon learning from the National Science Foundation (NSF) that Aldrin "now holds the record as the oldest person to reach the South Pole at the age of 86," his Mission Director Christina Korp jokingly said: 'He'll be insufferable now. (
  • Aldrin is produced by combining hexachlorocyclopentadiene with norbornadiene in a Diels-Alder reaction to give the adduct. (
  • The names dieldrin and aldrin are derived from the Diels-Alder chemical reaction, and their pronunciation should reflect the names of the German chemists Dr O. Diels and Dr K. Alder. (
  • 1971. Effect of aldrin on the condition avoidance response and electroshock seizure threshold of offspring from aldrin-treated mother. (
  • ALDRIN/DIELDRIN JMPR 1975 Explanation The Codex Committee on Pesticide Residues at its eighth session (1975) reiterated its request to governments to provide information on the use of these compounds on fruit crops. (
  • More information is required from governments on uses for aldrin and dieldrin that are currently authorized and on residues found in different commodities. (
  • Information on current use patterns and residue monitoring to indicate the level and incidence of aldrin/dieldrin residues in food. (
  • In 1975, Aldrin checked in to a rehabilitation center, though he did not achieve sobriety until three years later, in 1978. (
  • In "Magnificent Desolation: The Long Journey Home From the Moon," Aldrin recounts that experience - from takeoff to splashdown - in breathtaking detail, and his harrowing return to normal life after the mission, when the astronaut battled depression and alcoholism. (
  • Astronaut and second man on the Moon Buzz Aldrin came down with clinical depression after the Moon Landing . (
  • As Aldrin navigated his new life and career after the moon landing mission, he began to experience feelings of isolation and depression-even as the world celebrated in his success. (
  • Aldrin buried his pain and depression, not allowing himself to share how he was feeling with others. (
  • As his depression worsened, Aldrin found himself turning to alcohol. (
  • Aldrin reflected on his mental health in his memoir, exploring his familial connections to depression more in-depth. (
  • Throughout the 1970s, Aldrin continued to struggle with depression and alcoholism, even being forced to take a job as a car salesman to make ends meet-an unsuccessful venture and low point for the once-celebrated astronaut at the peak of his professional success. (
  • Tyson and Aldrin speak about the future of American space missions and the mission to Mars. (
  • Dr Buzz Aldrin to provide industry leaders ith insight into his vision for space exploration, mission to Mars legacy and his views on the latest developments in aerospace and space technology. (
  • Buzz Aldrin, celebrated Apollo astronaut and an outspoken champion for the pursuit of space exploration has written a new book titled "Mission to Mars. (
  • Aldrin says that while Mars is the destination, getting there is a journey that includes taking advantage of the efforts from commercial space companies, embracing space tourism, working towards planetary defense, developing technology, promoting STEM (science, technology, engineering and mathematics) education, and working together with international partners. (
  • What Aldrin calls his "unified vision" could provide a timeline of crewed missions to Mars is between 2035-2040. (
  • Mission to Mars" is written from Aldrin's perspective, and Aldrin and David spend little time looking back at the past achievements of Gemini and Apollo, and instead look forward of how the next steps in space exploration should be taken. (
  • Aldrin, who showed a photo of himself at Stonehenge wearing a shirt that says, "Get your ass to Mars," also discussed some of the famous elbows he's bumped, including theoretical physicist Stephen Hawking. (
  • Embracing a path of sobriety over 37 years ago, today Aldrin is an energized visionary, hoping to inspire the world in a joint effort to bring a human settlement to Mars. (
  • The author of nine books, Aldrin most recently published his children's book, Welcome to Mars: Making a Home on the Red Planet and his latest best-seller, No Dream Is Too High: Life Lessons from a Man Who Walked on the Moon , with National Geographic. (
  • The gala benefits my Buzz Aldrin Space Foundation to promote and fund space education and hopefully to help inspire and create the next generation of game changers. (
  • More than 40 years after the historic moon landing, Aldrin is now consulting for the U.S. government about the future of the country's space program and how to make space more accessible to everyday people. (
  • Nowadays, Aldrin spends most of his time on the road, with a schedule packed with scuba diving trips, international meetings on space, visiting members of Congress and developing his nonprofit organization, which aims to build interest in space and advocate for affordable space travel. (
  • They have also assumed control of Col. Aldrin's "space memorabilia, space artifacts, social media accounts and all elements of the Buzz Aldrin brand," according to the suit, filed in a Florida state court. (
  • Tyson talks with Aldrin about how astronauts eliminate waste in space. (
  • Aldrin explains the UCD and hydrologic engineering in space suits. (
  • Aldrin , 85, wants to expand his long-term space exploration program that includes human spaceflight, robotics and science initiatives. (
  • Another photo displayed what Aldrin called "The first space selfie. (
  • Aldrin shed light on aspects of astronaut training, detailing a space simulation method that includes being submerged underwater with a pressurized suit counterbalanced with weights. (
  • Aldrin retired from the space programme in 1973 and rejoined the air force in a managerial role. (
  • Buzz Aldrin has tweeted a picture of himself in space, orbiting the earth in 1966, in arguably one of the best selfies ever. (
  • As a precaution, following discussion between the White Desert doctor and the US Antarctic Program (USAP) doctor, Mr Aldrin, accompanied by a member of his team, was evacuated on the first available flight out of the South Pole to McMurdo with the USAP under the care of a USAP doctor,' continued the statement. (
  • Col. Aldrin said in an interview he was shocked last month when his two children asked a Florida state court to appoint them his co-guardians because he is "in cognitive decline" and experiencing paranoia and confusion. (
  • Aldrin, who is one of the only astronauts from that era who is still living, had mostly been quiet about the film, although he did send a tweet during the flag controversy, about a month before the film was released. (
  • In the Aldrin children's request for a mental examination of their father, they mention Ms. Korp as a person with knowledge of his "cognitive decline. (
  • Aldrin is considered moderately persistent in the environment, with a half-life of approximately 110 days. (
  • Aldrin and dieldrin have shown to cause liver cancer in mice. (
  • Pregnant albino mice at the third stage of gestation were given Aldrin (2 m/kg or 4 mg/kg body weight) or corn oil (10 cm 3 /kg body weight) orally daily for seven consecutive days. (
  • Bioassays of technical-grade aldrin and dieldrin for possible carcinogenicity were conducted by administering the test materials in feed to Osborne-Mendel rats and B6C3F1 mice. (
  • Groups of 50 mice of each sex were administered aldrin at one of two doses for 80 weeks, then observed for 10-13 weeks. (
  • Aldrin produced no significant effect on the mortality of rats or of male mice, but there was a dose-related trend in the mortality of female mice, primarily due to the early deaths in the high-dose groups. (
  • Aldrin Garcia is an American amateur skateboarder who as of 2011 held the world record for highest Ollie at 45 inches. (
  • Around the time First Man debuted at the Toronto Film Festival in September, a controversy arose about the film's decision to not directly show Armstrong and Aldrin planting the American flag on the moon. (
  • A true American hero, Aldrin fought to find a greater role for himself in the years after the Apollo mission. (
  • In previous posts Saturday, Aldrin shared photos of himself wearing a T-shirt with the tagline "Buzz Aldrin, Future Martian" that shows an astronaut planting the American flag on the Red Planet. (
  • Hailed as American heroes, Aldrin and Armstrong returned from their mission to much fanfare. (
  • In June, Aldrin filed a lawsuit against his children and his family foundation, while his children counter-sued, alleging that Aldrin had been manipulated by others into taking that action. (