Aldrin
Dieldrin
Heptachlor
Endrin
Hydrocarbons, Chlorinated
Chlordan
Pesticide Residues
Insecticides
Benzopyrene Hydroxylase
Abnormalities in the microsomal oxidases of the WHO standard reference strain of Musca domestica. (1/19)
Observations made during biochemical and toxicological studies of the housefly, in which the WHO standard reference (SR) strain was used as a standard, indicated that this strain differs from other strains in certain physiological and toxicological aspects. Experiments are described in which microsomal oxidases prepared from the standard reference strain and several other housefly strains, both susceptible and resistant to insecticides, were compared for heat stability, sensitivity to ionic strength, pH optima, and the spectral characteristics of their cytochrome P-450. In a comparison with 8 strains the SR strain microsomes were more stable at high incubation temperatures (40-47.5 degrees C). Compared to two other strains (NAIDM, susceptible, and Isolan-B, resistant) SR was more stable at low pH and more sensitive to high ionic strength. In spectral comparisons with NAIDM and Isolan-B, SR was found to contain microsomal cytochrome P-450 that differed slightly in its carbon monoxide or octylamine binding spectra. The results suggest that this strain may not provide a suitable reference in studies involving the microsomal oxidases. However, these apparent differences should not reduce the value of the SR stain as a reference in insecticide resistance studies. (+info)Aldrin and dieldrin: a review of research on their production, environmental deposition and fate, bioaccumulation, toxicology, and epidemiology in the United States. (2/19)
In the last decade four international agreements have focused on a group of chemical substances known as persistent organic pollutants (POPs). Global agreement on the reduction and eventual elimination of these substances by banning their production and trade is a long-term goal. Negotiations for these agreements have focused on the need to correlate data from scientists working on soil and water sampling and air pollution monitoring. Toxicologists and epidemiologists have focused on wildlife and human health effects and understanding patterns of disease requires better access to these data. In the last 20 years, substantial databases have been created and now are becoming available on the Internet. This review is a detailed examination of 2 of the 12 POPs, aldrin and dieldrin, and how scientific groups identify and measure their effects. It draws on research findings from a variety of environmental monitoring networks in the United States. An overview of the ecologic and health effects of aldrin and dieldrin provides examples of how to streamline some of the programs and improve access to mutually useful scientific data. The research groups are located in many government departments, universities, and private organizations. Identifying databases can provide an "information accelerator" useful to a larger audience and can help build better plant and animal research models across scientific fields. (+info)Normal-phase high-performance liquid chromatographic determination and identification of aldrin, dieldrin, and DDTs in eggs. (3/19)
A method for the routine monitoring of residual aldrin, dieldrin, pp'-DDT, op'-DDT, pp'-DDE, and pp'-DDD in eggs by high-performance liquid chromatography (HPLC) with a photo-diode array (PDA) detector is described. The lipids extracted from a whole egg are cleaned by a solid-phase extraction (SPE) ISOLUTE NH2 column with a diethyl ether-hexane (5:95, v/v) eluent. The HPLC separation is carried out using a normal-phase (LiChrosorb NH2) column, a heptane-hexane eluent (97:3, v/v), and a PDA detector. The average recoveries from fortified target compounds (0.1, 0.2, 0.3, and 0.4 microg/g, respectively) are > or = 83%, with standard deviations (SDs) between 2 and 5%. The interassay variabilities and their SDs are < or = 4.8% and < or =0.7%, with intra-assay variabilities of 2.1-3.3%. The limits of determination for these compounds range from 0.04 to 0.08 microg/g. (+info)Aldrin-induced locomotor activity: possible involvement of the central GABAergic-cholinergic-dopaminergic interaction. (4/19)
Aldrin (5 mg/kg/day, p.o.) under nontolerant condition, administered either for a single day or for 12 consecutive days, enhanced locomotor activity (LA) of rats. The increase in LA was greater in rats treated with aldrin for 12 consecutive days than that observed with a single dose. The aim of the present study is to evaluate the involvement of possible interactions of central GABAergic, cholinergic and dopaminergic systems using their agonist(s) and antagonist(s) in the regulation of LA in aldrin nontolerant rats. Administration of either L-DOPA along with carbidopa or bicuculline potentiated aldrin-induced increase in LA under nontolerant condition as well as LA of the control rats. Treatment with muscimol, haloperidol, atropine or physostigmine all decreased the LA of both aldrin nontolerant and control rats. Further, the application of (a) haloperidol along with bicuculline, atropine or physostigmine and (b) physostigmine along with bicuculline or L-DOPA + carbidopa significantly reduced LA but L-DOPA + carbidopa along with atropine or bicuculline increased LA of the control rats. These agonist(s)/antagonist(s)-induced decrease or increase in LA of the control rats were attenuated or potentiated, respectively, when those agonist(s)/antagonist(s) under abovementioned condition were administered to aldrin nontolerant rats. The attenuating or potentiating effects of aldrin on agonist(s)/antagonist(s) (either individually or in different combinations)-induced change in LA were greater in rats treated with aldrin for 12 consecutive days than that observed with a single-dose aldrin treatment. These results suggest that aldrin, under nontolerant condition, reduces central GABAergic activity and increases LA by activating dopaminergic system via inhibition of cholinergic activity. The treatment with aldrin for 12 consecutive days produces greater effect than that caused by a single-day treatment. (+info)Brain regional gamma-aminobutyric acid (GABA) and locomotor activity: effect of long-term aldrin exposure. (5/19)
Aldrin-induced stimulation of locomotor activity (LA) under nontolerant conditions was restored to control value after 20 or more consecutive days of aldrin administration. In contrast to the inhibition of GABAergic activity with aldrin under short-term conditions as observed in our previous study, the measurement of steady-state level of GABA, the activities of its metabolizing enzymes, turnover and the specific binding of GABA to its receptor in different regions of the brain of rats treated with aldrin (2 or 5 mg/kg/day, po) under long-term (for 30 consecutive days) conditions showed no change in the GABAergic activity in any regions of the rat brain. Moreover, the studies of the interaction between neurotransmitters (using agonist(s) and antagonist(s) of the respective neurotransmitter receptors) showed that long-term administration of aldrin restored the LA to control value by upregulation of central GABAergic activity through the interaction with dopaminergic and cholinergic systems. Thus, this result suggests that long-term aldrin exposure upregulated the central GABAergic activity inhibition under short-term aldrin treatment which may be a cause of restoration of LA stimulated by the short-term aldrin administration to its control value. (+info)Studies on photochemical reactions of air pollutants. XV. Photoreactivity of heptachloro-3'-cyclopentenyldioxy heptachloro-2-cyclopentene formed by exposure of hexachlorocyclopentadiene to ultraviolet light in air. (6/19)
Hexachlorocyclopentadiene (HCCP, 1), one of the starting materials in the synthesis of aldrin (3), was found to be able to epoxidize aldrin (3) to give dieldrin (4) when exposed to artificial light at wavelengths longer than 290 nm. In this photochemical reaction, heptachloro-3'-cyclopentenyldioxy heptachloro-2-cyclopentene (2) was isolated as a key intermediate, which appears to be derived from the interaction between the triplet state of photo-excited HCCP (1) and triplet oxygen (3sigma(g)-), but not from that between the ground state of HCCP (1) and singlet oxygen (1delta(g)). The peroxide (2) plays an important role in the formation of dieldrin (4), because it utilized oxygen atom derived from oxygen in air for the epoxidation. (+info)Comparative biodegradation of alkyl halide insecticides by the white rot fungus, Phanerochaete chrysosporium (BKM-F-1767). (7/19)
The ability of Phanerochaete chrysosporium to degrade six alkyl halide insecticides (aldrin, dieldrin, heptachlor, chlordane, lindane, and mirex) in liquid and soil-corncob matrices was compared by using 14C-labeled compounds. Of these, only [14C]lindane and [14C]chlordane underwent extensive biodegradation, as evidenced by the fact that 9.4 to 23.4% of these compounds were degraded to 14CO2 in 30 days in liquid cultures and 60 days in soil-corncob cultures inoculated with P. chrysosporium. Although [14C]aldrin, [14C]dieldrin, [14C]heptachlor, and [14D]mirex were poorly mineralized, substantial bioconversion occurred, as determined by substrate disappearance and metabolite formation. Nonbiological disappearance was observed only with chlordane and heptachlor. (+info)Occupational exposure to organochlorine insecticides and cancer incidence in the Agricultural Health Study. (8/19)
Organochlorine (OC) insecticides have been regulated as possible human carcinogens primarily on the basis of animal studies. However, the epidemiologic evidence is inconsistent. We investigated the relationship between cancer incidence and OC insecticide use among pesticide applicators enrolled in the Agricultural Health Study, a prospective cohort study of 57,311 licensed applicators in Iowa and North Carolina enrolled between 1993 and 1997. Information on ever use of 7 OC insecticides (aldrin, chlordane, DDT, dieldrin, heptachlor, lindane, toxaphene) was collected from a self-administered questionnaire at enrollment. Lifetime exposure-days to OC insecticides were calculated using additional data from a take-home questionnaire completed by 25,291 participants (44% of total). We found no clear evidence of an association between use of OC insecticides and incident cancers (N = 1,150) ascertained through December, 2002. When we focused on individual insecticides and structurally similar groups (aldrin and dieldrin; chlordane and heptachlor), significantly increased relative risks of some cancers were observed for use of some chemicals (rectal cancer and chlordane, lung cancer and dieldrin, non-Hodgkin lymphoma (NHL) and lindane, melanoma and toxaphene, leukemia and chlordane/heptachlor). Some significant decreased relative risks were also observed (colon cancer and aldrin; overall cancer and heptachlor). In conclusion, we did not observe any clear relationship between cancer risk and the use of OC insecticides. Our chemical-specific findings are based on small numbers and multiple comparisons, and should be interpreted with caution; however, some observed associations (lindane and NHL, chlordane/heptachlor and leukemia) are supported by previous evidence. (+info)In the medical field, "Aldrin" refers to a chlorinated hydrocarbon insecticide that was widely used in the past. It is a member of the class of chemicals known as organochlorines, which were commonly used as pesticides in the mid-20th century. Aldrin was first synthesized in 1947 and was used as an insecticide for a variety of crops, including cotton, corn, and rice. It was also used as a rodenticide and as a treatment for lice and scabies. However, Aldrin has been shown to have toxic effects on humans and wildlife. It can cause a range of symptoms, including nausea, vomiting, dizziness, and headaches. Long-term exposure to Aldrin has been linked to liver and kidney damage, as well as reproductive problems and cancer. As a result of its toxic effects, the use of Aldrin has been restricted or banned in many countries. It is no longer used as a pesticide in the United States, but it may still be found in some older products or in contaminated soil and water.
Dieldrin is a synthetic insecticide that was widely used in agriculture and public health programs until it was banned in many countries due to its toxicity and persistence in the environment. It is a member of the chlorinated hydrocarbon class of insecticides and is structurally similar to other chlorinated hydrocarbons such as DDT and chlordane. In the medical field, dieldrin is primarily associated with its toxic effects on humans and animals. Exposure to dieldrin can cause a range of symptoms, including nausea, vomiting, dizziness, headache, and skin irritation. Long-term exposure to high levels of dieldrin has been linked to more serious health effects, such as liver and kidney damage, reproductive problems, and cancer. Dieldrin is also a persistent organic pollutant, meaning that it does not break down easily in the environment and can accumulate in the food chain. This has led to concerns about its impact on wildlife and ecosystems, as well as on human health through exposure to contaminated food and water.
Heptachlor is a synthetic organochlorine insecticide that was widely used in agriculture and for pest control in the past. It is no longer used in most countries due to its toxicity and persistence in the environment. In the medical field, heptachlor has been associated with a range of health effects, including liver and kidney damage, neurological disorders, and cancer. Long-term exposure to heptachlor has been linked to an increased risk of breast cancer in women. Heptachlor is also a known endocrine disruptor, meaning that it can interfere with the normal functioning of hormones in the body. This can lead to a range of health problems, including reproductive issues, developmental problems in children, and an increased risk of certain cancers. Overall, heptachlor is considered to be a hazardous substance and its use is highly regulated or banned in many countries.
Endrin is a synthetic insecticide that was widely used in agriculture and public health programs until its production was banned in many countries due to its toxicity and persistence in the environment. It is a member of the chlorinated hydrocarbon class of chemicals and is structurally similar to other insecticides such as DDT and lindane. In the medical field, endrin is not typically used as a therapeutic agent. However, exposure to endrin can have serious health effects, including neurological damage, liver and kidney toxicity, and reproductive problems. It can also cause cancer in animals, although the evidence for its carcinogenicity in humans is less clear. In cases of accidental or intentional exposure to endrin, medical treatment may involve supportive care to manage symptoms and prevent complications. In some cases, antidotes may be available to counteract the effects of endrin poisoning. However, the best way to prevent exposure to endrin and other harmful chemicals is through proper use and disposal of pesticides and other chemicals, as well as through public education and awareness campaigns.
In the medical field, "Hydrocarbons, Chlorinated" refers to a group of organic compounds that contain carbon and hydrogen atoms, with one or more chlorine atoms replacing some of the hydrogen atoms. These compounds are commonly used as solvents, degreasers, and in the production of various chemicals and plastics. Some chlorinated hydrocarbons, such as trichloroethylene (TCE) and perchloroethylene (PCE), have been linked to various health problems, including liver and kidney damage, cancer, and reproductive issues. Exposure to these compounds can occur through inhalation, ingestion, or skin contact, and can occur in the workplace or through contaminated water and soil. In recent years, there has been growing concern about the potential health effects of chlorinated hydrocarbons, and efforts have been made to reduce their use and exposure.
I'm sorry, but I couldn't find any information on a medical term called "Chlordan." It's possible that you may have misspelled the term or that it is not a commonly used term in the medical field. If you could provide more information or context, I may be able to assist you further.
Benzopyrene Hydroxylase (CYP1A1) is an enzyme that plays a crucial role in the metabolism of polycyclic aromatic hydrocarbons (PAHs), including the potent carcinogen benzo[a]pyrene. It is encoded by the CYP1A1 gene and is primarily expressed in the liver, lungs, and skin. The primary function of CYP1A1 is to catalyze the hydroxylation of PAHs, which converts them into more polar and water-soluble metabolites that can be more easily excreted from the body. This process is an important step in the body's defense against the toxic and carcinogenic effects of PAHs. Deficiency or mutations in the CYP1A1 gene can lead to reduced activity of the enzyme, which can result in increased susceptibility to PAH-induced toxicity and cancer. In addition, exposure to certain environmental factors, such as cigarette smoke and air pollution, can induce the expression of CYP1A1, leading to increased metabolism of PAHs and potentially increased cancer risk.
Lindane is a synthetic insecticide that was widely used in agriculture and for the treatment of lice and scabies in humans. It is a member of the hexachlorocyclohexane (HCH) family of chemicals, which are known to be persistent in the environment and can bioaccumulate in the food chain. In the medical field, Lindane was previously used as an anti-scabies and anti-lice agent. However, its use has been restricted or banned in many countries due to concerns about its toxicity and potential health effects. Lindane is a known neurotoxin and can cause dizziness, headache, nausea, and seizures. Long-term exposure to Lindane has been linked to liver and kidney damage, as well as an increased risk of cancer. In recent years, alternative treatments for scabies and lice have been developed that are safer and more effective than Lindane. These include permethrin, ivermectin, and benzyl benzoate.
Buzz Aldrin Says US Presidential Candidates Should Aim for Mars | Space
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Buzz Aldrin Punches Guy in the Face (VIDEO) - Outside the Beltway
User aldrin - Server Fault
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TIME Brings Buzz Aldrin, Reggie Watts Recordings to LIFE VR | Time
Dr. Buzz Aldrin Archives - West Point Association of Graduates
Orion's Arm - Encyclopedia Galactica - Aldrin Tools
Armstrong and Aldrin Flag on Moon - American History for Kids Coloring Pages
AS11-40-5875 (Buzz Aldrin and the U.S. Flag)
"Algorithms for Library-Based Microbial Source Tracking" by Aldrin Montana
Men From Earth - First Edition - Signed - Buzz Aldrin - Bauman Rare Books
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on decks with dj aldrin
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Aldrin Miras, Author at UnGeek
Armstrong and Aldrin8
- While astronauts Armstrong and Aldrin descended in the LM, the "Eagle", to explore the Sea of Tranquility region of the Moon, astronaut Michael Collins, command module pilot, remained with the Command and Service Modules (CSM) "Columbia" in lunar-orbit. (si.edu)
- Left behind on the moon were the footprints of Armstrong and Aldrin , an American flag and scientific equipment. (youdao.com)
- He would wait in orbit around the moon while Armstrong and Aldrin landed and explored the surface. (youdao.com)
- What astronaut minded Apollo 2 while Armstrong and Aldrin history? (answers.com)
- I think you're asking which astronaut orbited the moon while Armstrong and Aldrin walked below. (answers.com)
- That man would be Michael Collins, who accompanied Armstrong and Aldrin on Apollo 11. (answers.com)
- What astronaut minded Apollo two wile Armstrong and Aldrin made history? (answers.com)
- Who was the other astronaut on Apollo 2 besides Armstrong and Aldrin? (answers.com)
Dieldrin for Possible Carcinogenicity1
- Bioassays of technical-grade aldrin and dieldrin for possible carcinogenicity were conducted by administering the test materials in feed to Osborne-Mendel rats and B6C3F1 mice. (nih.gov)
Apollo5
- Today in 1969, Apollo 11 astronauts Neil Armstrong and Edwin "Buzz" Aldrin became the first men to walk on the Moon . (cosmosmagazine.com)
- Astronaut Buzz Aldrin, lunar module pilot of the first lunar landing mission, poses for a photograph beside the deployed United States flag during an Apollo 11 Extravehicular Activity (EVA) on the lunar surface. (si.edu)
- After Apollo 11, Aldrin spent years struggling with mental depression and alcoholism. (apnews.com)
- The Apollo 11 crew that travelled to the moon included Neil Armstrong, Michael Collins, and Buzz Aldrin. (answers.com)
- What Apollo took Armstrong Aldrin and Collins to the moon? (answers.com)
Neil Armstrong7
- On July 21, 1969, Aldrin and Neil Armstrong were the first humans to set foot on the moon. (medscape.com)
- CAPE CANAVERAL, Fla. (AP) - Mission commander Neil Armstrong was the flying ace, Buzz Aldrin the scholar. (apnews.com)
- Americans Neil Armstrong and Edwin Buzz Aldrin landed on the moon on July twentieth, nineteen-sixty-nine. (youdao.com)
- Buzz Aldrin is a famous former American astronaut who is also an engineer and a fighter pilot who was the second man to walk on the moon after Neil Armstrong who was the first and mission commander for that project. (wealthyspy.com)
- Where was the third astronaut when Neil Armstrong and Buzz Aldrin were on the moon? (answers.com)
- What happened when Neil Armstrong and Buzz Aldrin made history? (answers.com)
- Neil Armstrong and Buzz Aldrin landed the lunar module Eagle on the moon on July 20, 1969. (answers.com)
Fuzz Aldrin1
- Blast off into space and impress your science loving friends when you show off your sweet Fuzz Aldrin bag. (boredwalk.com)
Astronaut4
- BOSTON - Iconic astronaut Edwin "Buzz" Aldrin, a passionate advocate for science education and exploration, will take the stage during the opening general session of Optometry's Meeting by the American Optometric Association (AOA). (medscape.com)
- Buzz Aldrin was the second man to walk on the moon, but the first astronaut to have a doctorate and dance with the stars. (apnews.com)
- Aldrin, now 89, had a long list of accomplishments by the time NASA chose him for the third astronaut group in 1963: third in his class at West Point, fighter pilot in Korea, Air Force officer, a doctorate in astronautics. (apnews.com)
- This funny astronaut cat bag is an a fun tribute to Buzz Aldrin and NASA. (boredwalk.com)
Bioassays1
- Aldrin undergoes metabolic conversion to the epoxide, dieldrin, and because of this structural relationship, reports of the bioassays of both chemicals have been combined in this single report. (nih.gov)
Heptachlor1
- We select 2*3ml 10% methanol/ether as the elution solvent for phthalates, Bisphenol A, 2,4-dichlorophenol and Nonyl phenyl, 3ml acetone and 3ml dichloromethane as the elution solvent for Hexachlorobenzene, Heptachlor epoxide and Aldrin . (youdao.com)
20181
- New Bedford, MA/USA-January 12, 2018): The 501(c)(3) non-profit advocacy group, the Inkwell Awards, began its 10th season anniversary by electing artists Aldrin Aw (aka Buzz) and Pat Broderick as new creator ambassadors to help further the group's mission of public promotion, education and recognition of the art form of inking and ink artists in the US comic book industry. (inkwellawards.com)
NASA1
- Dr Aldrin , whose book is reviewed here, would prefer NASA to aim for Mars directly. (youdao.com)
Moon3
- Mr Aldrin has truly seen the world from a different perspective, from the Moon. (youdao.com)
- Buzz Aldrin is known to be the first man to urinate on the moon. (wealthyspy.com)
- An authentically-signed, 8x10 color Kodak print of Buzz Aldrin on the Moon. (apolloastronauts.com)
Insecticides1
- Aldrin and dieldrin are organochlorine insecticides of the cyclodiene group. (nih.gov)
20161
- Cite this: All Eyes at Optometry's Meeting Will Be On Buzz Aldrin - Medscape - Jun 23, 2016. (medscape.com)
Buzz4
- He later legally changed his name from Edwin E. Aldrin Jr. to his childhood nickname Buzz. (apnews.com)
- Having the opportunity to meet amazing people like Buzz Aldrin and Sally Ride was incredible. (youdao.com)
- Buzz Aldrin was born on January 20, 1930, as Edwin Eugene Aldrin Jr. Buzz was born in Glen Ridge, New Jersey in the United States of America. (wealthyspy.com)
- Buzz Aldrin has passed a lie detector test after claiming that he has encountered alien life, it's been reported. (lintelligencer.com)
Groups4
- This review is a detailed examination of 2 of the 12 POPs, aldrin and dieldrin, and how scientific groups identify and measure their effects. (nih.gov)
- Groups of 50 rats of each sex were administered aldrin at one of two doses, either 30 or 60 ppm. (nih.gov)
- Groups of 50 mice of each sex were administered aldrin at one of two doses for 80 weeks, then observed for 10-13 weeks. (nih.gov)
- Aldrin produced no significant effect on the mortality of rats or of male mice, but there was a dose-related trend in the mortality of female mice, primarily due to the early deaths in the high-dose groups. (nih.gov)
Data2
High3
- Following detection of high aldrin and dieldrin concentrations in fish and river water in the Newlyn Catchment in 1988 enhanced routine pesticide monitoring has been carried out in this catchment. (environmentdata.org)
- There was an increased combined incidence of follicular-celladenoma and carcinoma of the thyroid both in male rats fed aldrin (matched controls 3/7, pooled controls 4/48, low-dose 14/38, high-dose 8/38) and female rats fed aldrin (matched controls 1/9, pooled controls 3/52, low-dose 10/39, high-dose 7/46). (nih.gov)
- Cortical adenoma of the adrenal gland was also observed in aldrin-treated rats in significant proportions (P=0.001) in low-dose (8/45) but not in high-dose (1/48) females when compared with pooled controls (0/55). (nih.gov)
List1
- Aldrin has not been listed in the list so far. (thinkbabynames.com)
Stars1
- Drawn toward the spotlight, Aldrin portrayed himself in a 1994 episode of the TV program "The Simpsons" and took a spin in 2010 on TV's "Dancing with the Stars. (apnews.com)
English1
- Aldrin is a variant form of Aldrich (Old English). (thinkbabynames.com)
Test1
- Genetic Toxicity Evaluation of Aldrin in Salmonella/E.coli Mutagenicity Test or Ames Test. (nih.gov)
Research1
- Aldrin and dieldrin: a review of research on their production, environmental deposition and fate, bioaccumulation, toxicology, and epidemiology in the United States. (nih.gov)