Aldosterone
Aldosterone Synthase
A mitochondrial cytochrome P450 enzyme that catalyzes the 18-hydroxylation of steroids in the presence of molecular oxygen and NADPH-specific flavoprotein. This enzyme, encoded by CYP11B2 gene, is important in the conversion of CORTICOSTERONE to 18-hydroxycorticosterone and the subsequent conversion to ALDOSTERONE.
Mineralocorticoid Receptor Antagonists
Receptors, Mineralocorticoid
Spironolactone
A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
Hyperaldosteronism
Renin
Mineralocorticoids
A group of CORTICOSTEROIDS primarily associated with water and electrolyte balance. This is accomplished through the effect on ION TRANSPORT in renal tubules, resulting in retention of sodium and loss of potassium. Mineralocorticoid secretion is itself regulated by PLASMA VOLUME, serum potassium, and ANGIOTENSIN II.
Zona Glomerulosa
Steroid 11-beta-Hydroxylase
A mitochondrial cytochrome P450 enzyme that catalyzes the 11-beta-hydroxylation of steroids in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP11B1 gene, is important in the synthesis of CORTICOSTERONE and HYDROCORTISONE. Defects in CYP11B1 cause congenital adrenal hyperplasia (ADRENAL HYPERPLASIA, CONGENITAL).
Adrenal Glands
Sodium
Angiotensin II
An octapeptide that is a potent but labile vasoconstrictor. It is produced from angiotensin I after the removal of two amino acids at the C-terminal by ANGIOTENSIN CONVERTING ENZYME. The amino acid in position 5 varies in different species. To block VASOCONSTRICTION and HYPERTENSION effect of angiotensin II, patients are often treated with ACE INHIBITORS or with ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS.
Renin-Angiotensin System
A BLOOD PRESSURE regulating system of interacting components that include RENIN; ANGIOTENSINOGEN; ANGIOTENSIN CONVERTING ENZYME; ANGIOTENSIN I; ANGIOTENSIN II; and angiotensinase. Renin, an enzyme produced in the kidney, acts on angiotensinogen, an alpha-2 globulin produced by the liver, forming ANGIOTENSIN I. Angiotensin-converting enzyme, contained in the lung, acts on angiotensin I in the plasma converting it to ANGIOTENSIN II, an extremely powerful vasoconstrictor. Angiotensin II causes contraction of the arteriolar and renal VASCULAR SMOOTH MUSCLE, leading to retention of salt and water in the KIDNEY and increased arterial blood pressure. In addition, angiotensin II stimulates the release of ALDOSTERONE from the ADRENAL CORTEX, which in turn also increases salt and water retention in the kidney. Angiotensin-converting enzyme also breaks down BRADYKININ, a powerful vasodilator and component of the KALLIKREIN-KININ SYSTEM.
Adrenal Cortex
The outer layer of the adrenal gland. It is derived from MESODERM and comprised of three zones (outer ZONA GLOMERULOSA, middle ZONA FASCICULATA, and inner ZONA RETICULARIS) with each producing various steroids preferentially, such as ALDOSTERONE; HYDROCORTISONE; DEHYDROEPIANDROSTERONE; and ANDROSTENEDIONE. Adrenal cortex function is regulated by pituitary ADRENOCORTICOTROPIN.
Potassium
An element in the alkali group of metals with an atomic symbol K, atomic number 19, and atomic weight 39.10. It is the chief cation in the intracellular fluid of muscle and other cells. Potassium ion is a strong electrolyte that plays a significant role in the regulation of fluid volume and maintenance of the WATER-ELECTROLYTE BALANCE.
11-beta-Hydroxysteroid Dehydrogenase Type 2
An high-affinity, NAD-dependent 11-beta-hydroxysteroid dehydrogenase that acts unidirectionally to catalyze the dehydrogenation of CORTISOL to CORTISONE. It is found predominantly in mineralocorticoid target tissues such as the KIDNEY; COLON; SWEAT GLANDS; and the PLACENTA. Absence of the enzyme leads to a fatal form of childhood hypertension termed, APPARENT MINERALOCORTICOID EXCESS SYNDROME.
Epithelial Sodium Channels
Adrenocorticotropic Hormone
An anterior pituitary hormone that stimulates the ADRENAL CORTEX and its production of CORTICOSTEROIDS. ACTH is a 39-amino acid polypeptide of which the N-terminal 24-amino acid segment is identical in all species and contains the adrenocorticotrophic activity. Upon further tissue-specific processing, ACTH can yield ALPHA-MSH and corticotrophin-like intermediate lobe peptide (CLIP).
Kidney Tubules, Collecting
Hypertension
Hydrocortisone
Diet, Sodium-Restricted
Corticosterone
Kidney
Sodium, Dietary
Desoxycorticosterone
Hypokalemia
Abnormally low potassium concentration in the blood. It may result from potassium loss by renal secretion or by the gastrointestinal route, as by vomiting or diarrhea. It may be manifested clinically by neuromuscular disorders ranging from weakness to paralysis, by electrocardiographic abnormalities (depression of the T wave and elevation of the U wave), by renal disease, and by gastrointestinal disorders. (Dorland, 27th ed)
Kidney Tubules, Distal
18-Hydroxydesoxycorticosterone
Amiloride
A pyrazine compound inhibiting SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions. Amiloride is used in conjunction with DIURETICS to spare POTASSIUM loss. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p705)
Electrolytes
Hypoaldosteronism
A congenital or acquired condition of insufficient production of ALDOSTERONE by the ADRENAL CORTEX leading to diminished aldosterone-mediated synthesis of Na(+)-K(+)-EXCHANGING ATPASE in renal tubular cells. Clinical symptoms include HYPERKALEMIA, sodium-wasting, HYPOTENSION, and sometimes metabolic ACIDOSIS.
Water-Electrolyte Balance
Adrenocortical Adenoma
A benign neoplasm of the ADRENAL CORTEX. It is characterized by a well-defined nodular lesion, usually less than 2.5 cm. Most adrenocortical adenomas are nonfunctional. The functional ones are yellow and contain LIPIDS. Depending on the cell type or cortical zone involved, they may produce ALDOSTERONE; HYDROCORTISONE; DEHYDROEPIANDROSTERONE; and/or ANDROSTENEDIONE.
Atrial Natriuretic Factor
Furosemide
Angiotensin-Converting Enzyme Inhibitors
A class of drugs whose main indications are the treatment of hypertension and heart failure. They exert their hemodynamic effect mainly by inhibiting the renin-angiotensin system. They also modulate sympathetic nervous system activity and increase prostaglandin synthesis. They cause mainly vasodilation and mild natriuresis without affecting heart rate and contractility.
Sodium Chloride Symporters
Sodium Channels
Receptors, Glucocorticoid
Cytoplasmic proteins that specifically bind glucocorticoids and mediate their cellular effects. The glucocorticoid receptor-glucocorticoid complex acts in the nucleus to induce transcription of DNA. Glucocorticoids were named for their actions on blood glucose concentration, but they have equally important effects on protein and fat metabolism. Cortisol is the most important example.
Rats, Sprague-Dawley
Hyperkalemia
Abnormally high potassium concentration in the blood, most often due to defective renal excretion. It is characterized clinically by electrocardiographic abnormalities (elevated T waves and depressed P waves, and eventually by atrial asystole). In severe cases, weakness and flaccid paralysis may occur. (Dorland, 27th ed)
Vasopressins
Antidiuretic hormones released by the NEUROHYPOPHYSIS of all vertebrates (structure varies with species) to regulate water balance and OSMOLARITY. In general, vasopressin is a nonapeptide consisting of a six-amino-acid ring with a cysteine 1 to cysteine 6 disulfide bridge or an octapeptide containing a CYSTINE. All mammals have arginine vasopressin except the pig with a lysine at position 8. Vasopressin, a vasoconstrictor, acts on the KIDNEY COLLECTING DUCTS to increase water reabsorption, increase blood volume and blood pressure.
Fadrozole
Potassium Deficiency
A condition due to decreased dietary intake of potassium, as in starvation or failure to administer in intravenous solutions, or to gastrointestinal loss in diarrhea, chronic laxative abuse, vomiting, gastric suction, or bowel diversion. Severe potassium deficiency may produce muscular weakness and lead to paralysis and respiratory failure. Muscular malfunction may result in hypoventilation, paralytic ileus, hypotension, muscle twitches, tetany, and rhabomyolysis. Nephropathy from potassium deficit impairs the concentrating mechanism, producing POLYURIA and decreased maximal urinary concentrating ability with secondary POLYDIPSIA. (Merck Manual, 16th ed)
Angiotensin II Type 1 Receptor Blockers
Diuresis
Dose-Response Relationship, Drug
11-beta-Hydroxysteroid Dehydrogenases
RNA, Messenger
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Glycyrrhiza
Hydroxysteroid Dehydrogenases
Captopril
A potent and specific inhibitor of PEPTIDYL-DIPEPTIDASE A. It blocks the conversion of ANGIOTENSIN I to ANGIOTENSIN II, a vasoconstrictor and important regulator of arterial blood pressure. Captopril acts to suppress the RENIN-ANGIOTENSIN SYSTEM and inhibits pressure responses to exogenous angiotensin.
Kidney Cortex
Antihypertensive Agents
Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS.
Receptor, Angiotensin, Type 1
Fibrosis
Rats, Wistar
Stimulation, Chemical
The increase in a measurable parameter of a PHYSIOLOGICAL PROCESS, including cellular, microbial, and plant; immunological, cardiovascular, respiratory, reproductive, urinary, digestive, neural, musculoskeletal, ocular, and skin physiological processes; or METABOLIC PROCESS, including enzymatic and other pharmacological processes, by a drug or other chemical.
Cells, Cultured
Peptidyl-Dipeptidase A
A peptidyl-dipeptidase that catalyzes the release of a C-terminal dipeptide, -Xaa-*-Xbb-Xcc, when neither Xaa nor Xbb is Pro. It is a Cl(-)-dependent, zinc glycoprotein that is generally membrane-bound and active at neutral pH. It may also have endopeptidase activity on some substrates. (From Enzyme Nomenclature, 1992) EC 3.4.15.1.
Acute and chronic dose-response relationships for angiotensin, aldosterone, and arterial pressure at varying levels of sodium intake. (1/2815)
We examined the acute and chronic dose-response relationships between intravenously infused angiotensin II (A II) and the resulting changes in arterial pressure and plasma aldosterone concentration at varying levels of sodium intake. Sequential analysis of plasma aldosterone at each A II infusion rate resulted in an acute dose-related increase in plasma aldosterone which was markedly attenuated after the first 24 hours of infusion, the final level being directly related to the dose of A II and inversely related to sodium intake. A II infused at 5,15, and 23 ng/kg per min was associated with an initial increase (2nd to 8th hour) in plasma aldosterone to 2,6, and 9 times control values, respectively, in dogs receiving 40 mEq Na+/day. But, after the 1st day, aldosterone averaged only 1, 1.7, and 3 times control values for the next 2 weeks at the same rates of A II infusion. Dogs receiving 120 mEq Na+/day during A II infusion exhibited only a transient increase in plasma aldosterone during the 1st day. Sustained hypertension developed over a period of a week at all doses of A II at normal and high sodium intake, but did not occur at any dose of A II in sodium-depleted dogs. Increasing sodium intake from 40 to 120 mEq/day resulted in higher levels of hypertension, 125% compared to 140% of ocntrol values for dogs infused with A II, 5.0 ng/kg per min. We conclude that primary angiotensin-induced hypertension need not be associated with increased levels of plasma aldosterone, which appears to remain elevated only with amounts of A II greater than those required to sustain a significant degree of hypertension. (+info)Low calorie diet enhances renal, hemodynamic, and humoral effects of exogenous atrial natriuretic peptide in obese hypertensives. (2/2815)
The expression of the natriuretic peptide clearance receptor is abundant in human and rat adipose tissue, where it is specifically inhibited by fasting. In obese hypertensives, plasma atrial natriuretic peptide (ANP) levels were found to be lower than in obese normotensives. Therefore, the increased adipose mass might influence ANP levels and/or its biological activity. The aim of the present study was to evaluate whether the humoral, hemodynamic, and renal effects of exogenous ANP in obese hypertensives might be enhanced by a very low calorie diet. Eight obese hypertensives received a bolus injection of ANP (0.6 mg/kg) after 2 weeks of a normal calorie/normal sodium diet, and blood pressure (BP), heart rate, ANP, cGMP, plasma renin activity, and aldosterone were evaluated for 2 hours before and after the injection. Diuresis and natriuresis were measured every 30 minutes. The patients then started a low calorie/normal sodium diet (510 kcal/150 mmol/d) for 4 days, and then the ANP injection protocol was repeated. The low calorie diet induced a slight weight loss (from 90.6+/-1.1 to 87. 7+/-1.2 kg; P<0.01), which was accompanied by increase of cGMP excretion (from 146.0+/-10.1 to 154.5+/-9.5 nmol/24 h; P<0.05) together with a reduction of BP (P<0.01 versus basal levels). ANP injection after diet was followed by an increase of ANP levels similar to that observed before diet, but plasma cGMP, diuresis, and natriuresis increased significantly only after diet. Similarly, the decrease of BP after ANP administration was significantly higher after diet (change in mean arterial pressure, -6.4+/-0.7 versus -4. 0+/-0.6 mm Hg; P<0.05) as well as that of aldosterone (P<0.01). These data show that a low calorie diet enhances the humoral, renal, and hemodynamic effects of ANP in obese hypertensives and confirm the importance of caloric intake in modulating the biological activity of ANP, suggesting that the natriuretic peptide system can play a role in the acute changes of natriuresis and diuresis associated with caloric restriction. (+info)Aldosterone excretion rate and blood pressure in essential hypertension are related to polymorphic differences in the aldosterone synthase gene CYP11B2. (3/2815)
Significant correlation of body sodium and potassium with blood pressure (BP) may suggest a role for aldosterone in essential hypertension. In patients with this disease, the ratio of plasma renin to plasma aldosterone may be lower than in control subjects and plasma aldosterone levels may be more sensitive to angiotensin II (Ang II) infusion. Because essential hypertension is partly genetic, it is possible that altered control of aldosterone synthase gene expression or translation may be responsible. We compared the frequency of 2 linked polymorphisms, one in the steroidogenic factor-1 (SF-1) binding site and the other an intronic conversion (IC), in groups of hypertensive and normotensive subjects. In a larger population, the relationship of aldosterone excretion rate to these polymorphisms was also evaluated. In 138 hypertensive subjects, there was a highly significant excess of TT homozygosity (SF-1) over CC homozygosity compared with a group of individually matched normotensive control subjects. The T allele was significantly more frequent than the C allele in the hypertensive group compared with the control group. Similarly, there was a highly significant relative excess of the conversion allele over the "wild-type" allele and of conversion homozygosity over wild-type homozygosity in the hypertensive group compared with the control group. In 486 subjects sampled from the North Glasgow Monitoring of Trends and Determinants in Cardiovascular Disease (MONICA) population, SF-1 and IC genotypes were compared with tetrahydroaldosterone excretion rate. Subjects with the SF-1 genotypes TT or TC had significantly higher excretion rates than those with the CC genotype. The T allele was associated with higher excretion rates than the C allele. However, no significant differences were found in excretion rate between subjects of different IC genotype. Urinary aldosterone excretion rate may be a useful intermediate phenotype linking these genotypes to raised BP. However, no causal relationship has yet been established, and it is possible that the polymorphisms may be in linkage with other causative mutations. (+info)Sodium requirement of adult cats for maintenance based on plasma aldosterone concentration. (4/2815)
The sodium requirement of adult cats for maintenance was determined using a randomized block design of eight dietary sodium treatments (0.1, 0.4, 0.5, 0.66, 0.8, 1.2, 1.6 or 2.0 g Na/kg in a casein-lactalbumin-based purified diet) administered for periods of 4 wk. A total of 35 adult specific-pathogen-free domestic shorthaired cats (26 males and 9 females, 1.5-3 y of age) was given an equilibration diet (2 g Na/kg) for 14 d before assignment (or reassignment) to the treatments. A total of 12 cats (8 males, 4 females) was randomly assigned to the lowest six levels of sodium, and four cats to the highest two sodium levels. Cats consuming the diet containing 0.1 g Na/kg had significantly elevated aldosterone concentration in plasma, and packed cell volume. In addition, these cats exhibited anorexia, body weight loss, reduced urinary specific gravity and sodium excretion, and had a negative sodium balance. However, adult cats did not develop polydypsia and polyuria reported in sodium-deficient kittens. Cats given the diet containing 0.66 g Na/kg did not have an increased packed cell volume, but aldosterone concentration in the plasma was significantly elevated. However, cats given diets containing >/=0.8 g Na/kg had plasma aldosterone concentrations +info)Epithelial sodium channel regulated by aldosterone-induced protein sgk. (5/2815)
Sodium homeostasis in terrestrial and freshwater vertebrates is controlled by the corticosteroid hormones, principally aldosterone, which stimulate electrogenic Na+ absorption in tight epithelia. Although aldosterone is known to increase apical membrane Na+ permeability in target cells through changes in gene transcription, the mechanistic basis of this effect remains poorly understood. The predominant early effect of aldosterone is to increase the activity of the epithelial sodium channel (ENaC), although ENaC mRNA and protein levels do not change initially. Rather, the open probability and/or number of channels in the apical membrane are greatly increased by unknown modulators. To identify hormone-stimulated gene products that modulate ENaC activity, a subtracted cDNA library was generated from A6 cells, a stable cell line of renal distal nephron origin, and the effect of candidates on ENaC activity was tested in a coexpression assay. We report here the identification of sgk (serum and glucocorticoid-regulated kinase), a member of the serine-threonine kinase family, as an aldosterone-induced regulator of ENaC activity. sgk mRNA and protein were strongly and rapidly hormone stimulated both in A6 cells and in rat kidney. Furthermore, sgk stimulated ENaC activity approximately 7-fold when they were coexpressed in Xenopus laevis oocytes. These data suggest that sgk plays a central role in aldosterone regulation of Na+ absorption and thus in the control of extracellular fluid volume, blood pressure, and sodium homeostasis. (+info)Primary aldosteronism with aldosterone-producing adrenal adenoma in a pregnant woman. (6/2815)
A 30-year-old pregnant woman complained of muscle weakness at 29 weeks' gestation. She was hypertensive with severe hypokalemia. Lower plasma renin activity and higher aldosterone level than the normal values in pregnancy suggested primary aldosteronism. A cesarean delivery was performed at 31 weeks' gestation because of pulmonary congestion. The neonatal course was uncomplicated. The laparoscopic adrenalectomy for a 2.0-cm right adrenal adenoma resulted in normalizing of her blood pressure and serum potassium level. Although primary aldosteronism is rare, especially during pregnancy, it should be always considered as one of etiologies of hypertension in pregnancy. (+info)Aldosterone, not estradiol, is the physiological agonist for rapid increases in cAMP in vascular smooth muscle cells. (7/2815)
BACKGROUND: Steroid-induced gene regulation in the endocrine tissues and vascular wall is achieved through the interaction of specific receptor proteins and promoters of target genes. In addition to these delayed steroid actions, rapid effects of steroids have been reported in various tissues that were clearly incompatible with the classic theory of genomic steroid action. METHODS AND RESULTS: Because high doses of 17beta-estradiol have been shown to modulate intracellular cAMP levels in vascular smooth muscle cells, steroid-induced stimulation of adenylate cyclase stimulation and phosphorylation of cAMP response element binding protein was investigated in porcine coronary artery vascular smooth muscle cells. Aldosterone induces a approximately 1.5- to 2.5-fold increase in intracellular cAMP levels (EC50 approximately 0.01 to 0.1 nmol/L) within 1 minute, whereas 17beta-estradiol and hydrocortisone act only at supraphysiological concentrations (10 micromol/L). Aldosterone-induced changes in intracellular cAMP are calcium dependent; they are not blocked by inhibitors of mineralocorticoid receptors, transcription, or protein synthesis. In addition, aldosterone induces a time-dependent phosphorylation of cAMP response element binding protein with potential transcriptional importance. CONCLUSIONS: A nongenomic modulation of vascular smooth muscle cells by aldosterone is consistent with the data that aldosterone, not estrogen, is the physiological stimulus for cAMP. (+info)Comparison of two aquaretic drugs (niravoline and OPC-31260) in cirrhotic rats with ascites and water retention. (8/2815)
kappa-Opioid receptor agonists (niravoline) or nonpeptide antidiuretic hormone (ADH) V2 receptor antagonists (OPC-31260) possess aquaretic activity in cirrhosis; however, there is no information concerning the effects induced by the chronic administration of these drugs under this condition. To compare the renal and hormonal effects induced by the long-term oral administration of niravoline, OPC-31260, or vehicle, urine volume, urinary osmolality, sodium excretion, and urinary excretion of aldosterone (ALD) and ADH were measured in basal conditions and for 10 days after the daily oral administration of niravoline, OPC-31260, or vehicle to cirrhotic rats with ascites and water retention. Creatinine clearance, serum osmolality, ADH mRNA expression, and systemic hemodynamics were also measured at the end of the study. Niravoline increased water excretion, peripheral resistance, serum osmolality, and sodium excretion and reduced creatinine clearance, ALD and ADH excretion, and mRNA expression of ADH. OPC-31260 also increased water metabolism and sodium excretion and reduced urinary ALD, although the aquaretic effect was only evident during the first 2 days, and no effects on serum osmolality, renal filtration, and systemic hemodynamics were observed. Therefore, both agents have aquaretic efficacy, but the beneficial therapeutic effects of the long-term oral administration of niravoline are more consistent than those of OPC-31260 in cirrhotic rats with ascites and water retention. (+info)
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Aldosterone
It selectively stimulates secretion of aldosterone. The secretion of aldosterone has a diurnal rhythm. Aldosterone is the ... Aldosterone is part of the renin-angiotensin-aldosterone system. It has a plasma half-life of less than 20 minutes. Drugs that ... Aldosterone is increased at low sodium intakes, but the rate of increase of plasma aldosterone as potassium rises in the serum ... A measurement of aldosterone in blood may be termed a plasma aldosterone concentration (PAC), which may be compared to plasma ...
Aldosterone synthase
Aldosterone is synthesized by following the metabolism of progesterone. In the potential case where aldosterone synthase is not ... Deficient aldosterone synthase activity results in impaired biosynthesis of aldosterone while corticosterone in the zona ... Aldosterone synthase converts 11-deoxycorticosterone to corticosterone, to 18-hydroxycorticosterone, and finally to aldosterone ... the renin-angiotensin-aldosterone system as a paradigm". Journal of the Renin-Angiotensin-Aldosterone System. 1 (4): 316-24. ...
Aldosterone escape
In physiology, aldosterone escape is a term that has been used to refer to two distinct phenomena involving aldosterone that ... Aldosterone initially results in an increase in Na+ reabsorption in these patients through stimulation of ENaC channels in ... This is the proposed mechanism of "mineralocorticoid escape" for how patients with increased levels of aldosterone are able to ... The inability of ACE inhibitor therapy to reliably suppress aldosterone release, for example, in patients with heart failure or ...
Aldosterone-to-renin ratio
... (ARR) is the mass concentration of aldosterone divided by the plasma renin activity or by serum ... Also, it can be given in pmol/L per µg/(L·h), where aldosterone is given in molar concentration. The former can be converted to ... The aldosterone/renin ratio is recommended as screening tool for primary hyperaldosteronism. There is more than one way to ... 1] Aldosterone-Renin Ratio in Primary Hyperaldosteronism by Allan S. Brett. Posted: 03/15/2005; Journal Watch. 2005;4(2) (All ...
Journal of the Renin-Angiotensin-Aldosterone System
... is a peer-reviewed academic journal that publishes papers in the field of ... Journal of the Renin-Angiotensin-Aldosterone System is abstracted and indexed in, among other databases: SCOPUS, and the Social ... Journal of the Renin-Angiotensin-Aldosterone System is a resource for biomedical professionals, including basic scientists and ... Journal of the Renin-Angiotensin-Aldosterone System also publishes research on other peptides, such as vasopressin, the ...
Drospirenone
It has about 100 to 500% of the affinity of aldosterone for the MR and about 50 to 230% of the affinity of progesterone for the ... 115-. ISBN 978-3-319-14385-9. Ménard J (2004). "The 45-year story of the development of an anti-aldosterone more specific than ... Drospirenone is an antagonist of the MR, the biological target of mineralocorticoids like aldosterone, and hence is an ... Oelkers W (February 2002). "The renin-aldosterone system and drospirenone". Gynecol. Endocrinol. 16 (1): 83-7. doi:10.1080/gye. ...
Prorenone
Similarly to spironolactone, prorenone is also a potent inhibitor of aldosterone biosynthesis. Prorenone can be synthesized via ... "Aldosterone antagonists. 2. Synthesis and biological activities of 11,12-dehydropregnane derivatives". J. Med. Chem. 30 (9): ... "Relative inhibitory potency of five mineralocorticoid antagonists on aldosterone biosynthesis in vitro". Biochemical ...
Primary aldosteronism
Rather, both renin and aldosterone are measured, and a resultant aldosterone-to-renin ratio (ARR) is used for case detection. A ... of cases Aldosterone-producing adrenocortical carcinoma: < 0.1% of cases 40% of people with an adrenal aldosterone producing ... Aldosterone has effects on most or all cells of the body but, clinically, the most important actions are in the kidney, on ... Tiu SC, Choi CH, Shek CC, Ng YW, Chan FK, Ng CM, Kong AP (January 2005). "The use of aldosterone-renin ratio as a diagnostic ...
Renin inhibitor
... and aldosterone receptor antagonists. These drugs inhibit the first and rate-limiting step of the renin-angiotensin-aldosterone ... This mechanism, which runs from renin through Ang II and to aldosterone, as well as the negative feedback that Ang II has on ... The renin-angiotensin-aldosterone system (RAAS) plays a key role in the pathology of cardiovascular disease, hypertension, ... Hsueh, W. A.; Wyne, K. (2011). "Renin-angiotensin-Aldosterone System in Diabetes and Hypertension". The Journal of Clinical ...
Steroidogenesis inhibitor
Aldosterone synthase (CYP11B2) inhibitors such as metyrapone, mitotane, and osilodrostat prevent the production of the potent ... Jürg Müller (6 December 2012). Regulation of Aldosterone Biosynthesis. Springer Science & Business Media. pp. 39-. ISBN 978-3- ... and aldosterone from the less potent corticosteroids 11-deoxycorticosterone and 11-deoxycortisol and are used in the diagnosis ... mineralocorticoid aldosterone from the less potent mineralocorticoid corticosterone. Osilodrostat was investigated for the ...
Corticosteroid 11-beta-dehydrogenase isozyme 2
HSD211B2 expression is also found in the brainstem in a small, aldosterone-sensitive subset of neurons located in the nucleus ... Corticosteroid 11-β-dehydrogenase isozyme 2 is an NAD+-dependent enzyme expressed in aldosterone-selective epithelial tissues ... thereby out-competing aldosterone in cells that do not produce HSD11B2. This glucocorticoid-inactivating enzyme is also ... "Aldosterone in the brain". American Journal of Physiology. Renal Physiology. 297 (3): F559-76. doi:10.1152/ajprenal.90399.2008 ...
Pimobendan
Spironolactone, an aldosterone antagonist. This has two actions, firstly, as a potassium-sparing diuretic, although its ... Secondly, it reduces aldosterone-mediated myocardial fibrosis, possibly slowing the progression of heart disease. An ACE ...
Distal convoluted tubule
Sodium absorption by the distal tubule is mediated by the hormone aldosterone. Aldosterone increases sodium reabsorption. ...
ACE inhibitor
Suppression of angiotensin II leads to a decrease in aldosterone levels. Since aldosterone is responsible for increasing the ... The renin-angiotensin-aldosterone system is a major blood pressure regulating mechanism. Markers of electrolyte and water ... High blood potassium is another possible complication of treatment with an ACE inhibitor due to its effect on aldosterone. ... ACE inhibitors reduce the activity of the renin-angiotensin-aldosterone system (RAAS) as the primary etiologic (causal) event ...
Aminoglutethimide
Aldosterone synthase (18-hydroxylase; CYP11B2). Prevents the conversion of corticosterone into aldosterone. As such, AG is an ... Aldosterone synthase inhibitors, Anticonvulsants, Antiglucocorticoids, Aromatase inhibitors, Cholesterol side-chain cleavage ...
Membrane mineralocorticoid receptor
Aldosterone has been found to have rapid non-genomic effects in the central nervous system, the kidneys, the cardiovascular ... It has been estimated that as much as 50% of the rapid actions of aldosterone are mediated by mMRs that are not the classical ... GPER, also known as GPR30, binds and is activated by aldosterone, and may be considered an mMR, although it also binds and is ... Harvey BJ, Alzamora R, Stubbs AK, Irnaten M, McEneaney V, Thomas W (2008). "Rapid responses to aldosterone in the kidney and ...
Barton reaction
In rigid systems such as aldosterone, the 1,5-hydrogen atom transfer is exceedingly fast, with a rate constant on the order of ... Barton, D. H. R.; Beaton, J. M. (1960). "A Synthesis of Aldosterone Acetate". Journal of the American Chemical Society. 82 (10 ... a synthesis of aldosterone acetate is demonstrated. Allowing corticosterone acetate to react with nitrosyl chloride in dry ...
Blood pressure
Angiotensin II also causes an increase in the release of aldosterone from the adrenal glands. Aldosterone further increases the ... Angiotensin II then signals to the adrenal cortex to release aldosterone. Aldosterone stimulates sodium retention and potassium ... The aldosterone system is directly targeted by spironolactone, an aldosterone antagonist. The fluid retention may be targeted ... Aldosterone release: This steroid hormone is released from the adrenal cortex in response to activation of the renin- ...
Cortisol
Bauman K, Muller J (1972). "Effect of potassium on the final status of aldosterone biosynthesis in the rat. I 18-hydroxylation ... The name cortisol is derived from cortex.) While the adrenal cortex also produces aldosterone (in the zona glomerulosa) and ... ISBN 978-0-471-06266-0. Muller AF, Oconnor CM (1958). An International Symposium on Aldosterone. Little Brown & Co. p. 58. ... High-potassium media (which stimulates aldosterone secretion in vitro) also stimulate cortisol secretion from the fasciculata ...
EMA401
J Renin Angiotensin Aldosterone Syst. 11 (1): 57-66. doi:10.1177/1470320309347790. PMID 19880657. US patent 4812462, BLANKLEY C ...
Mineralocorticoid
Aldosterone is produced in the zona glomerulosa of the cortex of the adrenal gland and its secretion is mediated principally by ... Aldosterone acts on the kidneys to provide active reabsorption of sodium and an associated passive reabsorption of water, as ... Aldosterone and cortisol (a glucosteroid) have similar affinity for the mineralocorticoid receptor; however, glucocorticoids ... Hypoaldosteronism (the syndrome caused by underproduction of aldosterone) leads to the salt-wasting state associated with ...
Adrenocortical hormone
For example, aldosterone functions to raise blood sodium levels and lower blood potassium levels by targeting the kidneys. ... Connell, J. M. C., & Davies, E. (2005). The new biology of aldosterone. Journal of Endocrinology, 186, 1-20.] Nelson, D. L., ... Examples of adrenocortical hormones that are involved in the stress response are aldosterone and cortisol. These hormones also ... hypoglycemia and decreased blood sodium levels and increased blood potassium levels caused by a deficiency of aldosterone. ...
Hyperkalemia
... decreasing the activity of the renin-angiotensin-aldosterone system, and impairing tubular responsiveness to aldosterone Kim, ... There is active excretion of potassium in the distal tubule and the collecting duct; both are controlled by aldosterone. In ... In chronic kidney disease, hyperkalemia occurs as a result of reduced aldosterone responsiveness and reduced sodium and water ... Mineralocorticoid (aldosterone) deficiency or resistance can also cause hyperkalemia. Primary adrenal insufficiency are: ...
Canrenone
Canrenoic acid Potassium canrenoate Jürg Müller (6 December 2012). Regulation of Aldosterone Biosynthesis: Physiological and ... 804-. ISBN 978-0-8155-1856-3. "List of Aldosterone receptor antagonists". "Potassium Uses, Side Effects & Interactions". ( ... Aldosterone synthase inhibitors, Antimineralocorticoids, Cholesterol side-chain cleavage enzyme inhibitors, CYP17A1 inhibitors ...
Endocrine system
Colombo L, Dalla Valle L, Fiore C, Armanini D, Belvedere P (April 2006). "Aldosterone and the conquest of land". Journal of ... All vertebrates have some form of a renin-angiotensin axis, and all tetrapods have aldosterone as a primary mineralocorticoid. ... TRH - TSH - T3/T4 GnRH - LH/FSH - sex hormones CRH - ACTH - cortisol Renin - angiotensin - aldosterone leptin vs. Ghrelin ...
Thrombospondin-2
"Thrombospondin expression in aldosterone-producing adenomas". Hypertension Research. 25 (4): 523-7. doi:10.1291/hypres.25.523. ...
Reabsorption
Angiotensin II stimulates the release of aldosterone, ADH, and thirst. Aldosterone causes kidneys to reabsorb sodium; ADH ...
Hypoadrenocorticism in dogs
The adrenal glands secrete glucocorticoids such as cortisol and mineralocorticoids such as aldosterone; when proper amounts of ... 2001). "Endocrinology-an Integrated Approach-Aldosterone". National Institutes of Health (US). Retrieved 25 January 2011. ... or possibly serum or plasma aldosterone during the ACTH stimulation test. While most corticosteroid drugs will invalidate the ...
Lipoid congenital adrenal hyperplasia
Renin but not aldosterone is elevated. Many infants born with this condition died before a method for diagnosis was recognized ... it is undamaged at birth and can make aldosterone for a while, so the eventual salt-wasting crisis develops more gradually and ...
Steroid hormone receptor
The cell membrane aldosterone receptor has shown to increase the activity of the basolateral Na/K ATPase, ENaC sodium channels ... Aldosterone) 3: Progesterone receptor (PR; NR3C3, PGR) (Sex hormones: Progesterone) 4: Androgen receptor (AR; NR3C4, AR) (Sex ...
Aldosterone Test: MedlinePlus Medical Test
An ALD test measures aldosterone in blood or urine. Learn more. ... Aldosterone (ALD) is a hormone that helps control blood ... Other names: aldosterone, serum; aldosterone urine; aldosterone-renin ratio test; aldosterone-plasma renin activity ... What is an aldosterone (ALD) test?. An aldosterone test measures the amount of aldosterone (ALD) in your blood or urine (pee). ... What happens during an aldosterone test?. An aldosterone (ALD) test uses a sample of blood or urine. A test that compares your ...
Aldosterone and Hypertension Among Hypercortisolism Patients
To what extent might aldosterone contribute to the occurrence of hypertension among patients with hypercortisolism? ... urine aldosterone, μg/day × 2.77 for nmol/d; Urine cortisol, μg/day × 2.76 for nmol/d.. Abbreviations: ARR, aldosterone-to- ... Urine aldosterone. 5.7 [3.9-10.1]. 7.2 [4.8-13.1]. 0.16. Conversion to SI units: ACTH, pg/mL × 0.220 for pmol; F, μg/dL × 27.6 ... Table 4. Aldosterone and cortisol response to ACTH a year after the adrenalectomy according to hypertension improvement status ...
Renal Volume, Renin-Angiotensin-Aldosterone System, Hyperten... : Journal of the American Society of Nephrology
The effect of renin-angiotensin-aldosterone system inhibition with dual blockade, ACEI and angiotensin receptor antagonists, on ... Renal Volume, Renin-Angiotensin-Aldosterone System, Hypertension, and Left Ventricular Hypertrophy in Patients with Autosomal ... Renal Volume, Renin-Angiotensin-Aldosterone System, Hypertension, and Left Ventricular Hypertrophy in Patients with Autosomal ... Renal Volume, Renin-Angiotensin-Aldosterone System, Hypertension, and Left Ventricular Hypertrophy in Patients with Autosomal ...
Aldosterone, post
Aldosterone Test: Procedure, Uses, and Results
Too much aldosterone can be an indicator of a variety of medical conditions. ... An ALD test measures the amount of the hormone aldosterone your blood. ... What is an aldosterone test?. An aldosterone (ALD) test measures the amount of ALD in your blood. Its also called a serum ... Preparing for aldosterone testing. Your doctor may ask you to have this test at a certain time of day. The timing is important ...
Talk:Aldosterone - Citizendium
AldoProâ„¢ (Aldosterone) | Antiaging Systems
... tablets contain the hormone Aldosterone, which helps to regulate blood pressure as well as aiding the bodys balance and ... Aldosterone (AldoProâ„¢). Aids balance and hearing Aldosterone is a hormone known to regulate essential salts and blood pressure ... The hormone Aldosterone is known to regulate essential salts and blood pressure in the body, but Aldosterone secretion may also ... Aldosterone secretion may also hold the key to loss of hearing.. Aldosterones important role in maintaining the bodys ...
Relationship between Plasma Aldosterone Levels and Left Ventricular Mass in Hypertensive Africans
Studies have suggested that the activity of the renin-angiotensin-aldosterone system play a major role in the target organ ... i ,Conclusions,/i,. In this group of hypertensive Africans, there is no independent association of plasma aldosterone with LV ... There were no univariate associations between LV mass index and plasma aldosterone (,svg style=vertical-align:-0.20474pt;width ... We sought to determine the relationship between plasma aldosterone and left ventricular mass in untreated African hypertensives ...
Gender Dysphoria Medication: Progestins, Gonadotropin-Releasing Hormone Agonists, Aldosterone Antagonists, Selective,...
Dual inhibition of renin-angiotensin-aldosterone system and endothelin-1 in treatment of chronic kidney disease
Inhibition of the renin-angiotensin-aldosterone system (RAAS) plays a pivotal role in treatment of chronic kidney diseases (CKD ... Dual inhibition of renin-angiotensin-aldosterone system and endothelin-1 in treatment of chronic kidney disease Am J Physiol ... Inhibition of the renin-angiotensin-aldosterone system (RAAS) plays a pivotal role in treatment of chronic kidney diseases (CKD ...
Aldosterone | Journal of Clinical Pathology
Umbrella analysis of the effect of renin-angiotensin-aldosterone system inhibitors on COVID-19 related outcomes
... *Download PDF ... Tags: ACE2, Acute Respiratory Distress Syndrome, Aldosterone, Angiotensin, Angiotensin-Converting Enzyme 2, Cardiovascular ... Umbrella analysis of the effect of renin-angiotensin-aldosterone system inhibitors on COVID-19 related outcomes. News-Medical ... Umbrella analysis of the effect of renin-angiotensin-aldosterone system inhibitors on COVID-19 related outcomes. News-Medical, ...
eAPPENDIX 2. RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM INHIBITOR DRUGS AND MAXIMUM DOSE LEVELS
JCI -
Usage information: Kinetics of RNA synthesis in toad bladder epithelium: action of aldosterone during the latent period
Aldosterone (5 × 10-7 mole/liter) produced no changes. If care were not taken to inhibit metabolism of native bacteria ... Processing of RNA in the toad bladder was analyzed by polyacrylamide-gel electrophoresis to determine whether aldosterone ... Kinetics of RNA synthesis in toad bladder epithelium: action of aldosterone during the latent period. ... Kinetics of RNA synthesis in toad bladder epithelium: action of aldosterone during the latent period. ...
Aldosterone Receptors - KRAS-G12C RESEARCH
blogadminAldosterone Receptors Therefore, we speculate that upon inducing ER tension in Smo-expressing cells, wild-type Smo ... blogadminAldosterone Receptors The overall objective response rate was 9 of 11 (81.8%), with 6 complete remissions (CRs) and 3 ... blogadminAldosterone Receptors Data Availability StatementAll relevant data are within the paper. Furthermore, knockdown of ... blogadminAldosterone Receptors Supplementary Materials1. identification of genes that get cell destiny acquisition. eTOC Liu ...
Erowid.org: Erowid Reference 102 : Effects of ecstasy on aldosterone secretion in the rat in vivo and in vitro : Burns N,...
Williams BC Effects of ecstasy on aldosterone secretion in the rat in vivo and in vitro Endocr Res 1996 22(4):601-6 ... In addition, MDMA can potentiate the direct action of 5-HT on aldosterone secretion in vitro by a mechanism which could be ... In study 1 basal aldosterone levels increased significantly from 3.490 +/- 1.1 nmol/l to 12.099 +/- 2 nmol/l after ... No consistent stimulation of aldosterone was observed by MDMA alone. In conclusion, acute administration of MDMA to conscious ...
Discovery of Potent and Selective Inhibitors of Human Aldosterone Synt
aldosterone. synthase. (CYP11B2). as. a. novel. target. for. the. treatment. of. these.diseases..Using.our. focused.compound. ... DOI link for Discovery of Potent and Selective Inhibitors of Human Aldosterone Synthase (CYP11B2): A New Target for the ... Discovery of Potent and Selective Inhibitors of Human Aldosterone Synthase (CYP11B2): A New Target for the Treatment of ... Discovery of Potent and Selective Inhibitors of Human Aldosterone Synthase (CYP11B2): A New Target for the Treatment of ...
LOINC LG50721-6 - Aldosterone^pre 250 ug corticotropin IM|Pt|Ser/Plas
LOINC Code LG50721-6 Aldosterone^pre 250 ug corticotropin IM,Pt,Ser/Plas ... LG50721-6Aldosterone^pre 250 ug corticotropin IM,. Pt,. Ser/PlasActive. Basic Attributes. Version First Released. Pending ... Aldosterone [Moles/volume] in Serum or Plasma --pre 250 ug corticotropin IM. ... Aldosterone [Mass/volume] in Serum or Plasma --pre 250 ug corticotropin IM. ...
"High aldosterone, hypertension and adrenal adenoma in a 36-year-old pr" by Amanda J. Berberich, Deborah Penava et al.
In comparison to the non-pregnant reference normal ranges, potassium was 3.1-3.9 mmol/L, aldosterone 2570-3000 pmol/L (N 250- ... Post-partum blood pressures remained elevated with normal aldosterone (539 pmol/L), unsuppressed renin (5.2 ng/L) and normal ... Pregnancy has significant effects on the renin-angiotensin-aldosterone pathway leading to physiologic elevations in both ... 2885) renin was unsuppressed (24-76.4 ng/L (N1.7-23.9)), with aldosterone to renin ratios in the reference range. An adrenal ...
RePub, Erasmus University Repository:
Differential effects of renin-angiotensin-aldosterone system inhibition,...
This adds weight to the hypothesis that inhibition of the renin-angiotensin- aldosterone system is an effective first step in ... Objectives: The objective of this study is to determine the effects of renin-angiotensin-aldosterone system inhibition, ... Differential effects of renin-angiotensin-aldosterone system inhibition, sympathoinhibition and diuretic therapy on endothelial ... inhibition of the renin-angiotensin-aldosterone system (using aliskiren 300 mg), sympathoinhibition (using moxonidine 0.4 mg), ...
ACTH and polymorphisms at steroidogenic loci as determinants of aldosterone secretion and blood pressure - Enlighten:...
Regulation of aldosterone and cortisol synthesis in hypertension and cardiovascular disease. Eleanor Davies. Medical Research ... While the renin angiotensin system is rightly regarded as the major driver of aldosterone secretion, there is increasing ... Special Issue: Selected Papers from the Renin-Angiotensin-Aldosterone System (RAAS)2016: Official Satellite of ISH2016, from ... ACTH and polymorphisms at steroidogenic loci as determinants of aldosterone secretion and blood pressure ...
Vasculometabolic and Inflammatory Effects of Aldosterone in Obesity
Radboudumc 16: Vascular damage RIHS: Radboud Institute for Health Sciences; Radboudumc 16: Vascular damage RIMLS: Radboud Institute for Molecular Life Sciences; Radboudumc 4: lnfectious Diseases and Global Health RIMLS: Radboud Institute for Molecular Life Sciences; Radboudumc 6: Metabolic Disorders RIMLS: Radboud Institute for Molecular Life Sciences ...
Association between renin-angiotensin-aldosterone system inhibitors and clinical outcomes in patients with COVID-19: A...
T1 - Association between renin-angiotensin-aldosterone system inhibitors and clinical outcomes in patients with COVID-19: A ... title = "Association between renin-angiotensin-aldosterone system inhibitors and clinical outcomes in patients with COVID-19: A ... Association between renin-angiotensin-aldosterone system inhibitors and clinical outcomes in patients with COVID-19: A ... Association between renin-angiotensin-aldosterone system inhibitors and clinical outcomes in patients with COVID-19: A ...
Aldosterone signaling defect in young infants: single-center report and review | BMC Endocrine Disorders | Full Text
Etiology of infant with aldosterone defect was mostly congenital. Renal and adrenal imaging are recommended to exclude renal ... If clinical picture is suggestive, normal plasma Ald in early infancy cannot rule out aldosterone insufficiency. ... aldosterone synthase deficiency (ASD, n = 4), and pseudo-hypoaldosteronism type 1 (PHA1, n = 1). Etiologies were not identified ... Aldosterone (Ald) is a crucial factor in maintaining electrolyte and water homeostasis. Defect in either its synthesis or ...
Analysis of renin-angiotensin aldosterone system gene polymorphisms in malaysian essential hypertensive and type 2 diabetic...
Gly460Trp of aldosterone and Lys173Arg of adducin (p > 0.05). However, the results for A6G of AGT gene revealed significant ... Gly460Trp of aldosterone synthase and Lys173Arg of adducin) of RAAS genes in Malaysian essential hypertensive and type 2 ... The renin-angiotensin aldosterone system (RAAS) plays an important role in regulating the blood pressure and the genetic ... Analysis of renin-angiotensin aldosterone system gene polymorphisms in malaysian essential hypertensive and type 2 diabetic ...
Aldosterone and Hypertension Among Hypercortisolism Patients
To what extent might aldosterone contribute to the occurrence of hypertension among patients with hypercortisolism? ... urine aldosterone, μg/day × 2.77 for nmol/d; Urine cortisol, μg/day × 2.76 for nmol/d.. Abbreviations: ARR, aldosterone-to- ... Urine aldosterone. 5.7 [3.9-10.1]. 7.2 [4.8-13.1]. 0.16. Conversion to SI units: ACTH, pg/mL × 0.220 for pmol; F, μg/dL × 27.6 ... Table 4. Aldosterone and cortisol response to ACTH a year after the adrenalectomy according to hypertension improvement status ...
Aldosterone stress
... cortisol and aldosterone. The fact Angiotensin II and aldosterone affect kidney oxygen handling differently. oxidative stress, ... aldosterone, catecholamines,. zona glomerulosa produces the mineralcorticoid aldosterone, whereas both the ACTH-release ... Renin-angiotensin aldosterone system and. Corticosteroid, aldosterone, hydrocortisone, kortison, 2, deoxycorticosterone, stress ... Aldosterone affects the bodys ability to regulate blood pressure.. Lexapro Fatigue - Can Lexapro cause weight changes?. Br J ...
ALDOSTERONE - Trackhub Health
aldosterone - Naturopathic Pediatrics
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SynthaseCortisol and aldosteroneSecretionAntagonistsCYP11B2RAASHypertensionSerumRegulatesPotassiumMineralocorticoidAntagonistReceptorsAngiotensinInhibitionHormoneSynthesisBody'sAdenomaPrimary aldosteronismPlasmaMineralocorticoidsPhysiologicSteroidCorticosteroneMeasurementUrineDeficiencyLeft ventricularKidneysELISABlood pressureStimulationEplerenoneTranscriptionalCongestive.heart.fSecreteRatioHttpsFindings
Synthase6
- Expression levels of the CD56 and the aldosterone synthase (CYP11B2) gene were markedly higher in CD56+ cells than CD56- cells (+1600 and +2100% increase, respectively). (unipd.it)
- IMSEAR at SEARO: Association of aldosterone synthase (CYP11B2 C-344T) gene polymorphism & susceptibility to essential hypertension in a south Indian Tamil population. (who.int)
- Aldosterone, synthesized by aldosterone synthase in the adrenal cortex is encoded by the CYP11B2 gene. (who.int)
- Osilodrostat (LCI-699) is an aldosterone synthase inhibitor (ASI). (pharmaceutical-technology.com)
- It is administered orally and acts by targeting aldosterone synthase. (pharmaceutical-technology.com)
- Aldosterone synthase (CYP11B2)-344T/C polymorphism and renoprotective response to losartan treatment in diabetic nephropathy. (cdc.gov)
Cortisol and aldosterone4
- Although previous studies have shown the coexistence of autonomous cortisol and aldosterone secretion, it is unclear whether aldosterone plays a role in hypertension among patients with hypercortisolism. (medscape.com)
- stress response after aneurysmal SAH was found to start within 15 minutes in the HPA axis with early peak values of ACTH, cortisol and aldosterone. (web.app)
- The adrenal glands make two main types of hormones: cortisol and aldosterone. (nih.gov)
- Addison's disease, hypoadrenocorticism, is an insufficient production of adrenal hormones cortisol and aldosterone. (blogspot.com)
Secretion13
- [ 7 ] Previous studies have reported that 10% to 20% of primary aldosteronism is accompanied by cortisol-producing adenoma, [ 8-10 ] and autonomous cortisol secretion was decreased after the resection of the aldosterone-producing adenoma (a subtype of primary aldosteronism). (medscape.com)
- Aldosterone secretion may also hold the key to loss of hearing. (antiaging-systems.com)
- The hormone Aldosterone is known to regulate essential salts and blood pressure in the body, but Aldosterone secretion may also hold the key to loss of hearing. (antiaging-systems.com)
- This study investigated the effects of Methylenedioxymethamphetamine (MDMA) on aldosterone and renin secretion via, (1) acute administration of MDMA to conscious Wistar rats, and (2) superfusion of whole rat adrenal capsules with 1 microM and 10 microM MDMA, in the presence of 5-HT. (erowid.org)
- Control rats showed no significant increase in aldosterone secretion. (erowid.org)
- In addition, MDMA can potentiate the direct action of 5-HT on aldosterone secretion in vitro by a mechanism which could be associated with the 5-HT transporter. (erowid.org)
- MacKenzie, S. M. , Freel, M. , Connell, J. M. , Fraser, R. and Davies, E. (2017) ACTH and polymorphisms at steroidogenic loci as determinants of aldosterone secretion and blood pressure. (gla.ac.uk)
- While the renin angiotensin system is rightly regarded as the major driver of aldosterone secretion, there is increasing evidence that the contribution of corticotropin (ACTH) is also significant. (gla.ac.uk)
- Aldosterone secretion is stimulated primarily via the renin angiotensin-aldosterone system (RAAS). (diametra.com)
- Moreover, aldosterone secretion was higher (+1380%) from CD56+ cells than from CD56- cells. (unipd.it)
- Angiotensin II also stimulates aldosterone secretion from the adrenal cortex, thereby contributing to sodium and fluid retention. (nih.gov)
- Inhibition of ACE results in decreased plasma angiotensin II and increased plasma renin activity (PRA), the latter resulting from loss of negative feedback on rennin release caused by reduction in angiotensin II.The reduction of angiotensin II leads to decreased aldosterone secretion, and, as a result, small increases in serum potassium may occur along with sodium and fluid loss. (nih.gov)
- Cushing's Syndrome results from excessive secretion of one or all of the adrenocortical hormones which includes glucocorticoid cortisol (predominant type), the mineralocorticoid aldosterone, and the adrogenital corticoids. (nursingcrib.com)
Antagonists10
- The effect of renin-angiotensin-aldosterone system inhibition with dual blockade, ACEI and angiotensin receptor antagonists, on renal volume and kidney function is under study in the Halt Progression of Polycystic Kidney Disease (HALT PKD) trial. (lww.com)
- Aldosterone antagonists may block androgen receptors. (medscape.com)
- In adults with longstanding heart failure or recent heart attack aldosterone antagonists reduced sudden cardiac deaths and deaths from any cause. (nihr.ac.uk)
- The findings are in line with current NICE guidance, which include aldosterone antagonists as options in the management of people with this specific type of heart failure or with left ventricular dysfunction after a recent heart attack. (nihr.ac.uk)
- Aldosterone antagonists are a group of medicines often used to manage heart failure. (nihr.ac.uk)
- Trials compared aldosterone antagonists spironolactone (15 trials), eplerenone (seven trials) or canrenoate potassium (three trials) to a placebo in most cases. (nihr.ac.uk)
- These findings suggest that aldosterone antagonists reduce sudden cardiac deaths, deaths from any cause, and hospitalisations for people with heart failure or a recent heart attack. (nihr.ac.uk)
- ACE inhibitors are a leading therapy (and subject to numerous new research papers) for intervening in the renin-angiotensin-aldosterone system along with angiotensin II type 1 receptor antagonists (2-4). (blogspot.com)
- Role of Angiotensin-Converting Enzyme Inhibitors, Angiotensin II Receptor Blockers, and Aldosterone Antagonists in the Prevention of Atrial and Ventricular Arrhythmias. (blogspot.com)
- vasodilators and aldosterone antagonists in the management of chronic heart failure. (bvsalud.org)
CYP11B21
- In this review article, we describe common polymorphisms at three steroidogenic loci (CYP11B2, CYP11B1 and CYP17A1) that alter gene transcription efficiency and levels of key steroids, including aldosterone. (gla.ac.uk)
RAAS6
- The activity of the renin-angiotensin-aldosterone system (RAAS) is thought to be the major contributor to the pathogenesis of hypertension and its sequelae [ 10 ]. (hindawi.com)
- Inhibition of the renin-angiotensin-aldosterone system (RAAS) plays a pivotal role in treatment of chronic kidney diseases (CKD). (nih.gov)
- In a recent study posted to the medRxiv * preprint server, researchers conducted an umbrella review and meta-analysis of the renin-angiotensin-aldosterone system (RAAS) inhibitors' impact on coronavirus disease 2019 (COVID-19) clinical outcomes. (news-medical.net)
- Det reglerar utsöndringen av adrenokortikotropiskt hormon, of an activated renin-angiotensin aldosterone system (RAAS) has been suggested. (web.app)
- Background & objective: Renin-angiotensin aldosterone system (RAAS) plays an important role in the regulation of blood pressure. (who.int)
- The body's renin-angiotensin-aldosterone system (RAAS) includes hormones that affect blood pressure regulation, and dysregulation of the RAAS can lead to the development of high blood pressure. (ladyinrainbow.com)
Hypertension16
- Therefore, we examined the associations of plasma aldosterone concentrations (PACs) with hypertension among patients with overt and subclinical hypercortisolism. (medscape.com)
- These findings indicate that aldosterone may contribute to hypertension among patients with subclinical hypercortisolism. (medscape.com)
- This raises another potential mechanism to cause hypertension such as the coexistence of hyperaldosteronism (ie, excess aldosterone that is an essential steroid hormone for sodium reabsorption, water retention, and blood pressure control). (medscape.com)
- Studies have suggested that the activity of the renin-angiotensin-aldosterone system play a major role in the target organ damage such as left ventricular hypertrophy occuring in hypertension. (hindawi.com)
- This study therefore attempts to determine the relationship between aldosterone levels and left ventricular mass in black subjects with essential hypertension. (hindawi.com)
- High aldosterone, hypertension and adrenal adenoma in a 36-year-old pr" by Amanda J. Berberich, Deborah Penava et al. (uwo.ca)
- High aldosterone, hypertension and adrenal adenoma in a 36-year-old pregnant patient: Is this primary aldosteronism? (uwo.ca)
- Objectives: The objective of this study is to determine the effects of renin-angiotensin-aldosterone system inhibition, sympathoinhibition and diuretic therapy on endothelial function and blood pressure in obesity-related hypertension. (eur.nl)
- Methods: A randomized, four-way, double-blind, crossover study in 31 adults with previously untreated obesity-related hypertension, in which the effects of 8 weeks' inhibition of the renin-angiotensin-aldosterone system (using aliskiren 300 mg), sympathoinhibition (using moxonidine 0.4 mg), diuretic therapy (using hydrochlorothiazide 25 mg) or placebo on flow-mediated dilation and 24-h blood pressure were compared. (eur.nl)
- This adds weight to the hypothesis that inhibition of the renin-angiotensin- aldosterone system is an effective first step in the treatment of obesity-related hypertension. (eur.nl)
- Therefore, aldosterone is now considered as emotional stress hormone which plays an important contribution to the pathogenesis of stress-dependent arterial hypertension (Antonov et al. (web.app)
- Aldosterone measurements are used in the diagnosis and treatment of primary aldosteronism 1 (PA), hypertension caused by primary aldosteronism, selective hyperaldosteronism, edematous states and other conditions of electrolyte balance. (diametra.com)
- Vitamin D appears to have association with aldosterone and hypertension. (blogspot.com)
- Primary aldosteronism is the most frequent form of secondary hypertension accounting for up to 5-10% of all hypertensive patients and it is caused by bilateral idiopathic hyperplasia in approximately two-thirds of cases and aldosterone-producing adenoma (Conn's syndrome) in one-third. (wildapricot.org)
- Patients with aldosterone producing adenomas have more severe hypertension, more frequent hypokalemia, higher plasma and urinary levels of aldosterone, and are younger than those with bilateral hyperplasia. (wildapricot.org)
- Its beneficial effects in hypertension and heart failure appear to result primarily from suppression of the renin-angiotensin-aldosterone system. (nih.gov)
Serum3
- It's also called a serum aldosterone test. (healthline.com)
- The Aldosterone ELISA is intended for the quantitative determination of Aldosterone in human serum, plasma or urine and is intended for laboratory use only. (diametra.com)
- Immunoreaction cartridges for in vitro diagnostic (IVD) use with the LUMIPULSE G System for the quantitative measurement of aldosterone in human serum, plasma, or urine. (fujirebio.com)
Regulates6
- In addition to Hyperaldosteronism, Aldosterone levels play a part in the function of the antidiuretic hormone (adh for short), which regulates the uptake and use of water by the body. (antiaging-systems.com)
- Aldosterone is a steroid hormone secreted by adrenal glands.It regulates the salt and water balance of the body and thus is categorized as a mineralocorticoid. (pharmaffiliates.com)
- It regulates blood pressure via sodium and potassium and excessive aldosterone levels are associated with cardiovascular and renal damage via tissue remodeling. (pharmaceutical-technology.com)
- Aldosterone regulates sodium and potassium levels. (blogspot.com)
- Aldosterone is a hormone secreted by your adrenals that regulates water levels and the concentration of minerals, like sodium, in your body, helping you stay hydrated. (healthywealthyhq.com)
- This serves to release aldosterone that regulates and lowers the body's blood pressure. (steamdiego.com)
Potassium9
- The body's sodium (salt), potassium and water levels are kept in equilibrium through aldosterone secreted by the adrenal gland. (antiaging-systems.com)
- This is because sodium and potassium levels - regulated as we know by Aldosterone - are also crucial to our hearing, hence the Aldosterone hearing loss correlation. (antiaging-systems.com)
- Characterised by high blood pressure and fatigue, Hyperaldosteronism is caused by the production of too much Aldosterone, which in turn lowers potassium levels in the blood. (antiaging-systems.com)
- An Aldosterone potassium link to the aging process has been established, as it's known that both potassium and Aldosterone levels decline with age (falling levels of potassium in particular being a factor in age related loss of hearing). (antiaging-systems.com)
- In comparison to the non-pregnant reference normal ranges, potassium was 3.1-3.9 mmol/L, aldosterone 2570-3000 pmol/L (N 250-2885) renin was unsuppressed (24-76.4 ng/L (N1.7-23.9)), with aldosterone to renin ratios in the reference range. (uwo.ca)
- Aldosterone acts on mineralocorticoid receptors within the principal cells of the distal tubule to increase reabsorption of sodium and chloride and decrease reabsorption of potassium and hydrogen. (diametra.com)
- PA is a collective term for a group of disorders whereby aldosterone production is unsuitably high for the circulating sodium level independent of angiotensin II and potassium levels and its production cannot be reduced by sodium loading 2 . (diametra.com)
- Aldosterone helps maintain the balance of the minerals sodium and potassium in your blood. (nih.gov)
- Even in the presence of increasing AGT and potassium levels, lower plasma Ang II concentrations may be because of reduced, albeit not absent, the reactivity of pig renin to cleave baboon AGT, suggesting an impaired response of the renin-angiotensin-aldosterone system to hypovolemic and hypotensive episodes. (bvsalud.org)
Mineralocorticoid3
- 2014-07-01 Aldosterone also called mineralocorticoid, is a hormone that is crucial for sodium conservation in the kidney, salivary glands, sweat glands and colon. (web.app)
- We provide evidence that the mineralocorticoid receptor (MR) is degraded by the ubiquitin-proteasome pathway in a ligand-dependent manner and that proteasomal inhibition results in increased accumulation of the MR with enhancement of transcriptional response to aldosterone. (elsevier.com)
- Aldosterone is the principal mineralocorticoid in humans and a critical regulator of fluid and electrolyte homeostasis. (pharmaceutical-technology.com)
Antagonist5
- Spironolactone is an aldosterone antagonist that competes with testosterone and dihydrotestosterone receptor sites. (medscape.com)
- Hospitalisation for any reason was also significantly reduced with aldosterone antagonist treatment compared to placebo or routine drug treatment. (nihr.ac.uk)
- The specialist could consider adding an aldosterone antagonist licensed for heart failure, particularly if the person has moderate to severe heart failure or has had a heart attack within the past month. (nihr.ac.uk)
- NICE guidance on myocardial infarction from 2013 recommends that people who have had an acute heart attack and who have symptoms and/or signs of heart failure and left ventricular systolic dysfunction, should be treated with an aldosterone antagonist licensed for post heart attack treatment. (nihr.ac.uk)
- 4) Spironolactone is an aldosterone antagonist. (examyear.com)
Receptors2
- If decreased blood pressure is detected, the adrenal gland is stimulated by these stretch receptors to release aldosterone, which increases sodium reabsorption from the urine, sweat, and the gut. (web.app)
- It selectively and competitively blocks the vasoconstricting and aldosterone-secreting effects of angiotensin II by selectively antagonising its binding to AT1 receptors. (com.bd)
Angiotensin18
- Renal Volume, Renin-Angiotensin-Aldosterone System, Hyperten. (lww.com)
- Renal cyst enlargement in ADPKD in adults is associated with stimulation of both the circulating and intrarenal renin-angiotensin-aldosterone system. (lww.com)
- In conclusion, acute administration of MDMA to conscious rats causes activation of the renin-angiotensin-aldosterone system. (erowid.org)
- Pregnancy has significant effects on the renin-angiotensin-aldosterone pathway leading to physiologic elevations in both aldosterone and renin. (uwo.ca)
- This study demonstrates that intense heat stress can cause remarkable changes in the three main components of the renin-angiotensin-aldosterone system. (web.app)
- The fact Angiotensin II and aldosterone affect kidney oxygen handling differently. (web.app)
- Xavier FE, Aras-López Aldosterone induces endothelial dysfunc- tion in resistance arteries from normotensive and Heat stress refers to mild discomfort, cramps, physiologic strain, and possibly Through the process of acclimatization, the rennin-angiotensin-aldosterone axis psykologiska stressen, och att interventionerna vanligen var inriktade till Richard V, Bouhanick B. Renin-angiotensin aldosterone system and. (web.app)
- Angiotensin II acts on the vascular system causing vasoconstriction as well as stimulating the adrenal cortex to secrete aldosterone. (diametra.com)
- Renin Angiotensin Aldosterone System Blockade: Little to No Rationale for ACE Inhibitor and ARB Combinations. (medbullets.com)
- Our understanding of the complexities and inter-related pathways of the renin-angiotensin-aldosterone system continues to evolve. (medbullets.com)
- Combining these classes, for the purpose of enhancing renin-angiotensin-aldosterone system blockade and incremental blood pressure, nephroprotective, and cardioprotective effects, logically has emerged as an area for scientific inquiry and clinical use. (medbullets.com)
- The role of the renin-angiotensin-aldosterone system in cardiovascular progenitor cell function. (blogspot.com)
- Renin-angiotensin-aldosterone system function in the pig-to-baboon kidney xenotransplantation model. (bvsalud.org)
- This study evaluated the renin-angiotensin-aldosterone system post- kidney xenotransplantation . (bvsalud.org)
- Plasma renin , angiotensinogen (AGT), angiotensin II (Ang II), aldosterone levels, and urine osmolality and electrolytes were measured in healthy pigs , healthy nonimmunosuppressed baboons , and immunosuppressed baboons with life -supporting pig kidney grafts . (bvsalud.org)
- The role of the sympathetic nervous system, epinephrine, norepinephrine, adrenocorticotrophic hormone, and the renin angiotensin aldosterone system in the control of blood pressure was discussed. (cdc.gov)
- Hyperkalemia can occur with NSAID use by suppression of the renin-angiotensin-aldosterone system in addition to diminished GFR. (sportsmedreview.com)
- The ACE converts angiotensin decapeptide inactive form into active octapeptide angiotensin II in the kidneys, especially in the renin-angiotensin-aldosterone system 13 . (ijpsr.com)
Inhibition3
- Adverse cardiovascular (CV) effects of non-steroidal anti-inflammatory drugs (NSAIDs) are largely independent of their cyclooxygenase (COX) enzyme selectivity, but could be a consequence of aldosterone 18 beta-glucuronidation inhibition (AGI), which varies between NSAIDS. (elsevier.com)
- Crilly, MA, Mangoni, AA & Knights, KM 2013, ' Aldosterone glucuronidation inhibition as a potential mechanism for arterial dysfunction associated with chronic celecoxib and diclofenac use in patients with rheumatoid arthritis ', Clinical and Experimental Rheumatology , vol. 31, no. 5, pp. 691-698. (elsevier.com)
- Inhibition of pcMTase resulted in a reduction of aldosterone-induced Na + transport demonstrating the necessity of pcMTase-mediated transmethylation for steroid induced Na + reabsorption. (uthscsa.edu)
Hormone8
- Aldosterone is a hormone known to regulate essential salts and blood pressure in the body. (antiaging-systems.com)
- Similar Aldosterone hearing loss work has also been carried out by Belgian antiaging hormone treatment specialist Dr Thierry Hertoghe . (antiaging-systems.com)
- Understanding this hormone will help you 25 Sep 2019 Aldosterone/MR Signaling, Oxidative Stress, and Vascular Dysfunction. (web.app)
- Aldosterone is a steroid hormone produced by the zona glomerulosa of the adrenal cortex in the adrenal gland. (diametra.com)
- Aldosterone (ALD) is a hormone made by the adrenal glands. (nurselk.com)
- Adrenal glands also regulate your blood plasma content through the production of a hormone called aldosterone. (shiepisclinic.com)
- This hormone from atrial cells ends up occurring if blood pressure elevates and, as opposed to aldosterone, causes excretion of sodium (1). (blogspot.com)
- Adrenal fatigue and HPA Axis dysfunction can affect your levels of a hormone named aldosterone. (adrenalfatiguesolution.com)
Synthesis1
- We conclude that RNA metabolism in the toad bladder is extraordinarily slow, that a major acceleration of de novo synthesis in response to physiologic doses of aldosterone was not demonstrable, and that some reports to the contrary may have been influenced by artifacts from bacterial RNA metabolism. (jci.org)
Body's1
- Aldosterone affects the body's ability to regulate blood pressure. (web.app)
Adenoma2
- We detected intense CD56 immunostaining in the zona glomerulosa (ZG) and medulla of the normal human adrenal gland and therefore identified CD56, the neural cell adhesion molecule, as a membrane antigen specific for the ZG, aldosterone-producing adenoma (APA), and chromaffin cells. (unipd.it)
- Optimal treatment for aldosterone-producing adenoma or unilateral hyperplasia is unilateral laparoscopic adrenalectomy. (wildapricot.org)
Primary aldosteronism2
- Aldosterone measurement is of help in the diagnosis and treatment of primary aldosteronism. (fujirebio.com)
- In its classical form, primary aldosteronism presents with aldosterone excess, low plasma renin activity and hypokalemia, but several reports indicate that normokalemic primary aldosteronism is the most common presenting sign of the disease. (wildapricot.org)
Plasma7
- We sought to determine the relationship between plasma aldosterone and left ventricular mass in untreated African hypertensives. (hindawi.com)
- Measurements obtained included echocardiographic LV mass index, plasma aldosterone and renin. (hindawi.com)
- In this group of hypertensive Africans, there is no independent association of plasma aldosterone with LV mass. (hindawi.com)
- It is thought that black subjects have inappropriately elevated levels of aldosterone relative to plasma renin activity [ 9 ]. (hindawi.com)
- aldosterone.plasma.concentration.in vivo.is.very.important. (taylorfrancis.com)
- A suppression dynamic test (fludrocortisone, saline infusion, oral salt-loading, and captopril test) is usually performed after a positive screening test to confirm inappropriately high plasma aldosterone levels. (wildapricot.org)
- Plasma aldosterone levels were unchanged. (bvsalud.org)
Mineralocorticoids2
Physiologic1
- Studies have shown that circulating aldosterone levels within the physiologic range are strongly related to increased risk of cardiovascular mortality, fatal stroke, and sudden cardiac death [ 11 ]. (hindawi.com)
Steroid2
- Aldosterone application increased pcMTase activity resulting in elevation of total protein methyl esterification in vivo, but pcMTase protein levels were not affected by steroid, suggesting that aldosterone increased activity independent of enzyme number. (uthscsa.edu)
- However, overexpression did not change Na + reabsorption in the absence of steroid, suggesting that pcMTase activity is not limiting Na + transport in the absence of steroid, but that subsequent to aldosterone addition, pcMTase activity becomes limiting. (uthscsa.edu)
Corticosterone1
- Nel glomerulare, i mineralocorticoidi (aldosterone) sono sintetizzati principalmente, nei glucocorticoidi fascicolari come il corticosterone e il cortisolo e negli androgeni reticolari come il deidroepiandrosterone e landrostenedione, resident evil 7 steroide benutzen. (brokencorner.net)
Measurement2
- The Aldosterone hearing loss conclusion followed a study of older men and women between 58 and 84, which included extensive hearing tests and the measurement of Aldosterone levels in the blood. (antiaging-systems.com)
- Morphology, gene expression studies, and aldosterone measurement confirmed that CD56 positive (+) cells were ZG and APA cells. (unipd.it)
Urine2
- An aldosterone test measures the amount of aldosterone (ALD) in your blood or urine (pee). (medlineplus.gov)
- An aldosterone (ALD) test uses a sample of blood or urine. (medlineplus.gov)
Deficiency3
- In the area of Aldosterone deficiency and hearing loss, the work of Dr Jonathan Wright in the US has looked beyond treatments such as hearing aids and surgery to consider the Aldosterone factor. (antiaging-systems.com)
- The movement to address Aldosterone deficiency in age related loss of hearing represents a real advance in treatment options, and a far less intrusive alternative to hearing aids. (antiaging-systems.com)
- Every time the pain comes, I am I put my hand what can i do about low blood pressure into the soil and grabbed it, because there aldosterone deficiency blood pressure was nothing else around me. (munsg.de)
Left ventricular2
- It has also been shown that chronic administration of aldosterone in animal models leads to cardiac fibrosis and left ventricular hypertrophy (LVH). (hindawi.com)
- Though previous studies, on predominantly white subjects, had not been conclusive on the relationship between left ventricular mass and aldosterone, very few of these studies have been done on black subjects. (hindawi.com)
Kidneys2
- Un stress thermique aigu est un activateur rapide et puissant de la sécrétion du système rénineangiotensine et de l'aldosterone au cours d'une alimentation 1 Nov 2018 Aldosterone is produced in the cortex of the adrenal glands, which are located above the kidneys. (web.app)
- This causes increased osmolarity in the extracellular fluid, which … 2021-02-23 Aldosterone is produced in the cortex of the adrenal glands, which are located above the kidneys. (web.app)
ELISA1
- Air-jet stress did not increase sympathetic reactivity but rather revealed av AC Hagblom · 2018 - azotemia - including validation of an aldosterone-ELISA in lämnades själva i rummet med dämpad belysning för att minska eventuell stress hos katten. (web.app)
Blood pressure3
- These would suggest a blood pressure independent effect of aldosterone on the heart. (hindawi.com)
- The majority of genes contributing to the heritable component of blood pressure remain unidentified, but there is substantial evidence to suggest that common polymorphisms at loci involved in the biosynthesis of the corticosteroids aldosterone and cortisol are important. (gla.ac.uk)
- Deficiencies of aldosterone are much less appreciated than deficiencies of cortisol, and lead to low blood pressure and high pulse, especially on standing, the desire to eat salt (salt-craving), dizziness or lightheadedness on standing, and palpitations. (web.app)
Stimulation2
- No consistent stimulation of aldosterone was observed by MDMA alone. (erowid.org)
- The Xenopus laevis distal tubule epithelial cell line A6 was used as a model epithelia to study the role of isoprenylcysteine-O-carboxyl methyltransferase (pcMTase) in aldosterone-mediated stimulation of Na + transport. (uthscsa.edu)
Eplerenone1
- Eplerenone (Epoxymexrenone) is a selective, highly specific and orally active aldosterone blocker (SAB). (medchemexpress.com)
Transcriptional1
- Mutation of lysine 715 and/or 367 within this PEST element failed to prevent degradation of MR protein or transcriptional activity mediated by aldosterone, indicating that other lysine residues are targeted by proteasomal degradation of MR. These findings demonstrate a coupling between MR up-regulation and transcriptional hyperactivity. (elsevier.com)
Congestive.heart.f1
- Pathophysiological.and.clinical.studies.have.demonstrated.that.aldosterone.plays.a. detrimental.role.in.congestive.heart.failure. (taylorfrancis.com)
Secrete1
- They also secrete important hormones, including aldosterone. (healthywealthyhq.com)
Ratio1
- This is called an aldosterone-renin ratio test. (medlineplus.gov)
Https1
- https://pubchem.ncbi.nlm.nih.gov/compound/Aldosterone. (vibratist.com)
Findings2
- Further multi-institutional and population-based studies are required to validate our findings and examine the clinical effectiveness of the intervention targeting aldosterone for such patients. (medscape.com)
- Following these findings, an Aldosterone hearing loss treatment regime was established by Dr Jonathan Wright at his clinic. (antiaging-systems.com)