KetosesSugar Alcohols: Polyhydric alcohols having no more than one hydroxy group attached to each carbon atom. They are formed by the reduction of the carbonyl group of a sugar to a hydroxyl group.(From Dorland, 28th ed)Aldehyde Reductase: An enzyme that catalyzes reversibly the oxidation of an aldose to an alditol. It possesses broad specificity for many aldoses. EC 1.1.1.21.Aldose-Ketose Isomerases: Enzymes that catalyze the interconversion of aldose and ketose compounds.Isomerases: A class of enzymes that catalyze geometric or structural changes within a molecule to form a single product. The reactions do not involve a net change in the concentrations of compounds other than the substrate and the product.(from Dorland, 28th ed) EC 5.Carbon-Carbon Double Bond Isomerases: Enzymes that catalyze the shifting of a carbon-carbon double bond from one position to another within the same molecule. EC 5.3.3.Peptidylprolyl Isomerase: An enzyme that catalyzes the isomerization of proline residues within proteins. EC 5.2.1.8.Amino Acid Isomerases: Enzymes that catalyze either the racemization or epimerization of chiral centers within amino acids or derivatives. EC 5.1.1.Carbohydrate Epimerases: Enzymes that catalyze the epimerization of chiral centers within carbohydrates or their derivatives. EC 5.1.3.Imidazolidines: Compounds based on reduced IMIDAZOLINES which contain no double bonds in the ring.Protein Disulfide-Isomerases: Sulfur-sulfur bond isomerases that catalyze the rearrangement of disulfide bonds within proteins during folding. Specific protein disulfide-isomerase isoenzymes also occur as subunits of PROCOLLAGEN-PROLINE DIOXYGENASE.Steroid Isomerases: Enzymes that catalyze the transposition of double bond(s) in a steroid molecule. EC 5.3.3.Cyclophilins: A family of peptidyl-prolyl cis-trans isomerases that bind to CYCLOSPORINS and regulate the IMMUNE SYSTEM. EC 5.2.1.-Sorbitol: A polyhydric alcohol with about half the sweetness of sucrose. Sorbitol occurs naturally and is also produced synthetically from glucose. It was formerly used as a diuretic and may still be used as a laxative and in irrigating solutions for some surgical procedures. It is also used in many manufacturing processes, as a pharmaceutical aid, and in several research applications.XyloseEncyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)Lactobacillus: A genus of gram-positive, microaerophilic, rod-shaped bacteria occurring widely in nature. Its species are also part of the many normal flora of the mouth, intestinal tract, and vagina of many mammals, including humans. Pathogenicity from this genus is rare.Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing): An enzyme that catalyzes the synthesis of fructose-6-phosphate plus GLUTAMINE from GLUTAMATE plus glucosamine-6-phosphate.Photorhabdus: A genus of gram-negative bacteria existing symbiotically with nematodes of the family Heterorhabditidae (see RHABDITOIDEA). These nematodes infect a variety of soil-dwelling insects. Upon entering an insect host, the nematode releases Photorhabdus from its intestinal tract and the bacterium establishes a lethal septicemia in the insect.Rhabditoidea: A superfamily of nematodes of the order RHABDITIDA. Characteristics include an open tube stoma and an excretory system with lateral canals.Insects: The class Insecta, in the phylum ARTHROPODA, whose members are characterized by division into three parts: head, thorax, and abdomen. They are the dominant group of animals on earth; several hundred thousand different kinds having been described. Three orders, HEMIPTERA; DIPTERA; and SIPHONAPTERA; are of medical interest in that they cause disease in humans and animals. (From Borror et al., An Introduction to the Study of Insects, 4th ed, p1)Xenorhabdus: A genus of gram-negative, facultatively anaerobic rod-shaped cells which are motile by peritrichous flagella. Late in the growth cycle, spheroplasts or coccoid bodies occur, resulting from disintegration of the cell wall. The natural habitat is the intestinal lumen of certain nematodes. (From Bergey's Manual of Determinative Bacteriology, 9th ed)Nematoda: A class of unsegmented helminths with fundamental bilateral symmetry and secondary triradiate symmetry of the oral and esophageal structures. Many species are parasites.Moths: Insects of the suborder Heterocera of the order LEPIDOPTERA.Larva: Wormlike or grublike stage, following the egg in the life cycle of insects, worms, and other metamorphosing animals.Fatigue: The state of weariness following a period of exertion, mental or physical, characterized by a decreased capacity for work and reduced efficiency to respond to stimuli.Databases, Protein: Databases containing information about PROTEINS such as AMINO ACID SEQUENCE; PROTEIN CONFORMATION; and other properties.Sequence Analysis, Protein: A process that includes the determination of AMINO ACID SEQUENCE of a protein (or peptide, oligopeptide or peptide fragment) and the information analysis of the sequence.Systems Integration: The procedures involved in combining separately developed modules, components, or subsystems so that they work together as a complete system. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Internet: A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.Proteome: The protein complement of an organism coded for by its genome.Proteins: Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.Tuberculosis: Any of the infectious diseases of man and other animals caused by species of MYCOBACTERIUM.Tuberculosis, Pulmonary: MYCOBACTERIUM infections of the lung.Tuberculosis, Multidrug-Resistant: Tuberculosis resistant to chemotherapy with two or more ANTITUBERCULAR AGENTS, including at least ISONIAZID and RIFAMPICIN. The problem of resistance is particularly troublesome in tuberculous OPPORTUNISTIC INFECTIONS associated with HIV INFECTIONS. It requires the use of second line drugs which are more toxic than the first line regimens. TB with isolates that have developed further resistance to at least three of the six classes of second line drugs is defined as EXTENSIVELY DRUG-RESISTANT TUBERCULOSIS.Mycobacterium tuberculosis: A species of gram-positive, aerobic bacteria that produces TUBERCULOSIS in humans, other primates, CATTLE; DOGS; and some other animals which have contact with humans. Growth tends to be in serpentine, cordlike masses in which the bacilli show a parallel orientation.Extensively Drug-Resistant Tuberculosis: Tuberculosis resistant to ISONIAZID and RIFAMPIN and at least three of the six main classes of second-line drugs (AMINOGLYCOSIDES; polypeptide agents; FLUOROQUINOLONES; THIOAMIDES; CYCLOSERINE; and PARA-AMINOSALICYLIC ACID) as defined by the CDC.Medical History Taking: Acquiring information from a patient on past medical conditions and treatments.Drug Resistance, Multiple, Bacterial: The ability of bacteria to resist or to become tolerant to several structurally and functionally distinct drugs simultaneously. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).Lactobacillus brevis: A species of gram-positive, rod-shaped LACTIC ACID bacteria that is frequently used as starter culture in SILAGE fermentation, sourdough, and lactic-acid-fermented types of beer and wine.Lactobacillaceae: A family of gram-positive bacteria found regularly in the mouth and intestinal tract of man and other animals, in food and dairy products, and in fermenting vegetable juices. A few species are highly pathogenic.Bacillus megaterium: A species of bacteria whose spores vary from round to elongate. It is a common soil saprophyte.Xylulose: A 5-carbon keto sugar.Indole-3-Glycerol-Phosphate Synthase: An enzyme in the tryptophan biosynthetic pathway. EC 4.1.1.48.Anthranilate Synthase: An enzyme that catalyzes the formation of anthranilate (o-aminobenzoate) and pyruvic acid from chorismate and glutamine. Anthranilate is the biosynthetic precursor of tryptophan and numerous secondary metabolites, including inducible plant defense compounds. EC 4.1.3.27.AminohydrolasesAnthranilate Phosphoribosyltransferase: An enzyme that catalyzes the formation of N-5'-phosphoribosylanthranilic acid from anthranilate and phosphoribosylpyrophosphate, the first step in tryptophan synthesis in E. coli. It exists in a complex with ANTHRANILATE SYNTHASE in bacteria. EC 2.4.2.18.Thermotoga maritima: A rod-shaped bacterium surrounded by a sheath-like structure which protrudes balloon-like beyond the ends of the cell. It is thermophilic, with growth occurring at temperatures as high as 90 degrees C. It is isolated from geothermally heated marine sediments or hot springs. (From Bergey's Manual of Determinative Bacteriology, 9th ed)ortho-Aminobenzoates: Benzoic acids, salts, or esters that contain an amino group attached to carbon number 2 or 6 of the benzene ring structure.Neutrons: Electrically neutral elementary particles found in all atomic nuclei except light hydrogen; the mass is equal to that of the proton and electron combined and they are unstable when isolated from the nucleus, undergoing beta decay. Slow, thermal, epithermal, and fast neutrons refer to the energy levels with which the neutrons are ejected from heavier nuclei during their decay.Monosaccharides: Simple sugars, carbohydrates which cannot be decomposed by hydrolysis. They are colorless crystalline substances with a sweet taste and have the same general formula CnH2nOn. (From Dorland, 28th ed)Neutron Diffraction: The scattering of NEUTRONS by matter, especially crystals, with accompanying variation in intensity due to interference effects. It is useful in CRYSTALLOGRAPHY and POWDER DIFFRACTION.Arthrobacter: A genus of asporogenous bacteria isolated from soil that displays a distinctive rod-coccus growth cycle.
Cobalt proteins. (1/391)
In the form of vitamin B12, cobalt plays a number of crucial roles in many biological functions. However, recent studies have provided information on the biochemistry and bioinorganic chemistry of several proteins containing cobalt in a form other than that in the corrin ring of vitamin B12. To date, eight noncorrin-cobalt-containing enzymes (methionine aminopeptidase, prolidase, nitrile hydratase, glucose isomerase, methylmalonyl-CoA carboxytransferase, aldehyde decarbonylase, lysine-2,3-aminomutase, and bromoperoxidase) have been isolated and characterized. A cobalt transporter is involved in the metallocenter biosynthesis of the host cobalt-containing enzyme, nitrile hydratase. Understanding the differences between cobalt and nickel transporters might lead to drug development for gastritis and peptic ulceration. (+info)Construction and characterization of Escherichia coli disruptants defective in the yaeM gene. (2/391)
Escherichia coli disruptants defective in the yaeM gene, which is located at 4.2 min on the chromosome map, were constructed and characterized. The disruptants showed auxotrophy for 2-C-methylerythritol, a free alcohol of 2-C-methyl-D-erythritol 4-phosphate that is a biosynthetic precursor in the nonmevalonate pathway. This result clearly shows that the yaeM gene is indeed involved in this pathway in E. coli. (+info)Efficient expression, purification and crystallisation of two hyperthermostable enzymes of histidine biosynthesis. (3/391)
Enzymes from hyperthermophiles can be efficiently purified after expression in mesophilic hosts and are well-suited for crystallisation attempts. Two enzymes of histidine biosynthesis from Thermotoga maritima, N'-((5'-phosphoribosyl)-formimino)-5-aminoimidazol-4-carb oxamid ribonucleotide isomerase and the cyclase moiety of imidazoleglycerol phosphate synthase, were overexpressed in Escherichia coli, both in their native and seleno-methionine-labelled forms, purified by heat precipitation of host proteins and crystallised. N'-((5'-phosphoribosyl)-formimino)-5-aminoimidazol-4-carb oxamid ribonucleotide isomerase crystallised in four different forms, all suitable for X-ray structure solution, and the cyclase moiety of imidazoleglycerol phosphate synthase yielded one crystal form that diffracted to atomic resolution. The obtained crystals will enable the determination of the first three-dimensional structures of enzymes from the histidine biosynthetic pathway. (+info)Cloning and heterologous expression of a cDNA encoding 1-deoxy-D-xylulose-5-phosphate reductoisomerase of Arabidopsis thaliana. (4/391)
Various plant isoprenoids are synthesized via the non-mevalonate pathway of isopentenyl diphosphate formation. In this pathway, 1-deoxy-D-xylulose 5-phosphate (DOXP), the first intermediate, is transformed to 2-C-methyl-D-erythritol 4-phosphate (MEP) by an enzyme which was recently cloned from Escherichia coli. In order to find a plant homologue of this 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR) we cloned a cDNA fragment from Arabidopsis thaliana which has high homology to the E. coli DXR. By expression of this fragment in E. coli we could demonstrate that it encodes a protein which transforms DOXP to MEP. The antibiotic fosmidomycin specifically inhibits this DXR enzyme activity. (+info)A molecular sensor that allows a gut commensal to control its nutrient foundation in a competitive ecosystem. (5/391)
Little is known about how members of the indigenous microflora interact with their mammalian hosts to establish mutually beneficial relationships. We have used a gnotobiotic mouse model to show that Bacteroides thetaiotaomicron, a component of the intestinal microflora of mice and humans, uses a repressor, FucR, as a molecular sensor of L-fucose availability. FucR coordinates expression of an operon encoding enzymes in the L-fucose metabolic pathway with expression of another locus that regulates production of fucosylated glycans in intestinal enterocytes. Genetic and biochemical studies indicate that FucR does this by using fucose as an inducer at one locus and as a corepressor at the other locus. Coordinating this commensal's immediate nutritional requirements with production of a host-derived energy source is consistent with its need to enter and persist within a competitive ecosystem. (+info)Gene silencing: Maintaining methylation patterns. (6/391)
Recent studies of an Arabidopsis gene family have shown that inverted repeats can be potent silencers of other identical sequences in the genome, causing them to become stably methylated at cytosine residues. From mutations affecting this process we are beginning to understand how methylation patterns are maintained. (+info)Increasing the thermostability of D-xylose isomerase by introduction of a proline into the turn of a random coil. (7/391)
Thermostability can be increased by introducing prolines at suitable sites in target proteins. Two single (G138P, G247D) mutants and one double (G138P/G247D) mutant of xylose isomerase from Streptomyces diastaticus No.7, strain M1033 have been constructed by site-directed mutagenesis. With respect to the wild-type enzyme, G138P showed about a 100% increase in thermostability, and G247D showed an increased catalytic activity. Significantly, the double mutant, G138P/G247D displayed even higher activity than G247D and better heat stability than G138P. Its half life was about 2.5-fold greater than the wild-type enzyme, using xylose as a substrate. Molecular modelling suggested that the introduction of a proline residue in the turn of a random coil may cause the surrounding conformation to be tightened by reducing the backbone flexibility. The change in thermostability can, therefore, be explained based on changes in the molecular rigidity. Furthermore, the improvements in the properties of the double mutant indicated that the advantages of two single mutants can be combined effectively. (+info)Arabidopsis PAI gene arrangements, cytosine methylation and expression. (8/391)
Previous analysis of the PAI tryptophan biosynthetic gene family in Arabidopsis thaliana revealed that the Wassilewskija (WS) ecotype has four PAI genes at three unlinked sites: a tail-to-tail inverted repeat at one locus (PAI1-PAI4) plus singlet genes at two other loci (PAI2 and PAI3). The four WS PAI genes are densely cytosine methylated over their regions of DNA identity. In contrast, the Columbia (Col) ecotype has three singlet PAI genes at the analogous loci (PAI1, PAI2, and PAI3) and no cytosine methylation. To understand the mechanism of PAI gene duplication at the polymorphic PAI1 locus, and to investigate the relationship between PAI gene arrangement and PAI gene methylation, we analyzed 39 additional ecotypes of Arabidopsis. Six ecotypes had PAI arrangements similar to WS, with an inverted repeat and dense PAI methylation. All other ecotypes had PAI arrangements similar to Col, with no PAI methylation. The novel PAI-methylated ecotypes provide insights into the mechanisms underlying PAI gene duplication and methylation, as well as the relationship between methylation and gene expression. (+info)... aldose-ketose isomerases MeSH D08.811.399.475.200.174 --- autocrine motility factor MeSH D08.811.399.475.200.350 --- glucose-6- ... triose-phosphate isomerase MeSH D08.811.399.475.400 --- carbon-carbon double bond isomerases MeSH D08.811.399.475.400.700 --- ... steroid isomerases MeSH D08.811.399.475.800 --- sulfur-sulfur bond isomerases MeSH D08.811.399.475.800.550 --- protein ... phosphate isomerase MeSH D08.811.399.475.200.550 --- mannose-6-phosphate isomerase MeSH D08.811.399.475.200.662 --- neuroleukin ...
Like most sugar isomerases, glucose isomerase catalyzes the interconversion of aldoses and ketoses. The conversion of glucose ... Phosphohexose Isomerase Dificiency (PHI) is also known as phosphoglucose isomerase deficiency or Glucose-6-phosphate isomerase ... Generally, "the names of isomerases are formed as "substrate isomerase" (for example, enoyl CoA isomerase), or as "substrate ... A ketose is then formed and the ring is closed again. Glucose-6-phosphate first binds to the active site of the isomerase. The ...
The systematic name of this enzyme class is D-arabinose aldose-ketose-isomerase. Other names in common use include D-arabinose( ... L-fucose) isomerase, D-arabinose isomerase, L-fucose isomerase, and D-arabinose ketol-isomerase. As of late 2007, only one ... This enzyme belongs to the family of isomerases, specifically those intramolecular oxidoreductases interconverting aldoses and ... In enzymology, an arabinose isomerase (EC 5.3.1.3) is an enzyme that catalyzes the chemical reaction D-arabinose ⇌ {\ ...
The systematic name of this enzyme class is hydroxypyruvate aldose-ketose-isomerase. This enzyme participates in glyoxylate and ... This enzyme belongs to the family of isomerases, specifically those intramolecular oxidoreductases interconverting aldoses and ... de Windt FE, van der Drift C (1980). "Purification and some properties of hydroxypyruvate isomerase of Bacillus fastidiosus". ... In enzymology, a hydroxypyruvate isomerase (EC 5.3.1.22) is an enzyme that catalyzes the chemical reaction hydroxypyruvate ⇌ {\ ...
... anthranilate aldose-ketose-isomerase. Other names in common use include: PRA isomerase, PRAI, IGPS:PRAI (indole-3-glycerol- ... As the name phosphoribosylanthranilate isomerase suggests, it functions as an isomerase, rearranging the parts of the molecule ... specifically those intramolecular oxidoreductases interconverting aldoses and ketoses. The systematic name of this enzyme class ... anthranilate ketol-isomerase. Phosphoribosylanthranilate isomerase (PRAI) is monomeric and labile in most mesophilic ...
The systematic name of this enzyme class is D-glucuronate aldose-ketose-isomerase. Other names in common use include uronic ... isomerase, uronate isomerase, D-glucuronate isomerase, uronic acid isomerase, and D-glucuronate ketol-isomerase. This enzyme ... This enzyme belongs to the family of isomerases, specifically those intramolecular oxidoreductases interconverting aldoses and ... In enzymology, a glucuronate isomerase (EC 5.3.1.12) is an enzyme that catalyzes the chemical reaction D-glucuronate ⇌ {\ ...
The systematic name of this enzyme class is D-xylose aldose-ketose-isomerase. Other names in common use include D-xylose ... specifically those intramolecular oxidoreductases interconverting aldoses and ketoses. The isomerase has now been observed in ... Xylose-isomerases are also commonly called fructose-isomerases due to their ability to interconvert glucose and fructose. ... isomerase, D-xylose ketoisomerase, and D-xylose ketol-isomerase. The activity of D-xylose isomerase was first observed by ...
The systematic name of this enzyme class is D-ribose aldose-ketose-isomerase. Other names in common use include D-ribose ... This enzyme belongs to the family of isomerases, specifically those intramolecular oxidoreductases interconverting aldoses and ... In enzymology, a ribose isomerase (EC 5.3.1.20) is an enzyme that catalyzes the chemical reaction D-ribose ⇌ {\displaystyle \ ... Izumori K, Rees AW, Elbein AD (1975). "Purification, crystallization, and properties of D-ribose isomerase from Mycobacterium ...
The systematic name of this enzyme class is D-mannose aldose-ketose-isomerase. Other names in common use include D-mannose ... This enzyme belongs to the family of isomerases, specifically those intramolecular oxidoreductases interconverting aldoses and ... In enzymology, a mannose isomerase (EC 5.3.1.7) is an enzyme that catalyzes the chemical reaction D-mannose ⇌ {\displaystyle \ ... Palleroni NJ; Doudoroff M (1956). "Mannose isomerase of Pseudomonas saccharophila". J. Biol. Chem. 218: 535-548. PMID 13278359 ...
... is an enzyme with systematic name D-glycero-D-manno-heptose 7-phosphate aldose-ketose-isomerase. This enzyme catalyses the ... D-sedoheptulose 7-phosphate isomerase (EC 5.3.1.28, sedoheptulose-7-phosphate isomerase, phosphoheptose isomerase, gmhA (gene ... Kim, M.S.; Shin, D.H. (2009). "A preliminary X-ray study of sedoheptulose-7-phosphate isomerase from Burkholderia pseudomallei ... D-sedoheptulose 7-phosphate isomerase at the US National Library of Medicine Medical Subject Headings (MeSH) Molecular and ...
The systematic name of this enzyme class is L-fucose aldose-ketose-isomerase. This enzyme participates in fructose and mannose ... This enzyme belongs to the family of isomerases, specifically those intramolecular oxidoreductases interconverting aldoses and ... In enzymology, a L-fucose isomerase (EC 5.3.1.25) is an enzyme that catalyzes the chemical reaction L-fucose ⇌ {\displaystyle \ ... The enzyme is a hexamer, forming the largest structurally known ketol isomerase, and has no sequence or structural similarity ...
The systematic name of this enzyme class is L-arabinose aldose-ketose-isomerase. This enzyme participates in pentose and ... This enzyme belongs to the family of isomerases, specifically those intramolecular oxidoreductases interconverting aldoses and ... L-arabinose isomerase". J. Biol. Chem. 231 (2): 1031-7. PMID 13539034. Nakamatu T, Yamanaka K (1969). "Crystallization and ... In enzymology, a L-arabinose isomerase (EC 5.3.1.4) is an enzyme that catalyzes the chemical reaction L-arabinose ⇌ {\ ...
The systematic name of this enzyme class is L-rhamnose aldose-ketose-isomerase. Other names in common use include rhamnose ... This enzyme belongs to the family of isomerases, specifically those intramolecular oxidoreductases interconverting aldoses and ... I L-RHAMNOSE ISOMERASE FROM LACTOBACILLUS PLANTARUM.]". Biochem. Z. 339: 145-53. PMID 14095156. Molecular and Cellular Biology ... In enzymology, a L-rhamnose isomerase (EC 5.3.1.14) is an enzyme that catalyzes the chemical reaction L-rhamnose ⇌ {\ ...
The systematic name of this enzyme class is 11-deoxycorticosterone aldose-ketose-isomerase. Martin KO, Oh SW, Lee HJ, Monder C ... This enzyme belongs to the family of isomerases, specifically those intramolecular oxidoreductases interconverting aldoses and ... In enzymology, a corticosteroid side-chain-isomerase (EC 5.3.1.21) is an enzyme that catalyzes the chemical reaction 11- ... Monder C, Martin KO, Bogumil J (1980). "Presence of epimerase activity in hamster liver corticosteroid side chain isomerase". J ...
The systematic name of this enzyme class is D-galactose-6-phosphate aldose-ketose-isomerase. This enzyme participates in ... This enzyme belongs to the family of isomerases, specifically those intramolecular oxidoreductases interconverting aldoses and ... In enzymology, a galactose-6-phosphate isomerase (EC 5.3.1.26) is an enzyme that catalyzes the chemical reaction D-galactose 6- ...
The systematic name of this enzyme class is D-arabinose-5-phosphate aldose-ketose-isomerase. Other names in common use include ... This enzyme belongs to the family of isomerases, specifically those intramolecular oxidoreductases interconverting aldoses and ... In enzymology, an arabinose-5-phosphate isomerase (EC 5.3.1.13) is an enzyme that catalyzes the chemical reaction D-arabinose 5 ... arabinose phosphate isomerase, phosphoarabinoisomerase, and D-arabinose-5-phosphate ketol-isomerase. Volk WA (1960). " ...
The systematic name of this enzyme class is D-lyxose aldose-ketose-isomerase. Other names in common use include D-lyxose ... This enzyme belongs to the family of isomerases, specifically those intramolecular oxidoreductases interconverting aldoses and ... In enzymology, a D-lyxose ketol-isomerase (EC 5.3.1.15) is an enzyme that catalyzes the chemical reaction D-lyxose ⇌ {\ ... ANDERSON RL, ALLISON DP (1965). "PURIFICATION AND CHARACTERIZATION OF D-LYXOSE ISOMERASE". J. Biol. Chem. 240: 2367-72. PMID ...
The systematic name of this enzyme class is D-ribose-5-phosphate aldose-ketose-isomerase. RpiA in human beings is encoded on ... Ribose-5-phosphate isomerase deficiency is mutated in a rare disorder, Ribose-5-phosphate isomerase deficiency. The disease has ... Ribose-5-phosphate isomerase (Rpi) is an enzyme that catalyzes the conversion between ribose-5-phosphate (R5P) and ribulose-5- ... The first is an insertion of a premature stop codon into the gene encoding the isomerase, and the second is a missense mutation ...
MPI must convert an aldose (mannose) to a ketose (fructose), in addition to opening and closing the rings for these sugars. In ... Mannose-6 phosphate isomerase (MPI), alternately phosphomannose isomerase (PMI) (EC 5.3.1.8) is an enzyme which facilitates the ... Anomeric Form used by Phosphomannose Isomerase and Its 1-Epimerization by Phosphoglucose Isomerase". The Journal of Biological ... "Structural Basis for Phosphomannose Isomerase Activity in Phosphoglucose Isomerase from Pyrobaculum Aerophilum: A Subtle ...
... aldose-ketose-isomerase, 1-phospho-5'-S-methylthioribose isomerase, and S-methyl-5-thio-D-ribose-1-phosphate aldose-ketose- ... The systematic name of this enzyme class is S-methyl-5-thio-alpha-D-ribose-1-phosphate aldose-ketose-isomerase. Other names in ... This enzyme belongs to the family of isomerases, specifically those intramolecular oxidoreductases interconverting aldoses and ... 1-PMTR isomerase, 5-methylthio-5-deoxy-D-ribose-1-phosphate ketol-isomerase, S-methyl-5-thio-5-deoxy-D-ribose-1-phosphate ketol ...
... imidazole-4-carboxamide aldose-ketose-isomerase. This enzyme catalyses the following chemical reaction 1-(5-phosphoribosyl)-5 ... 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide isomerase (EC 5.3.1.16, N-(5'-phospho-D ... 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide isomerase at the US National Library of ... isomerase) of histidine biosynthesis from Salmonella typhimurium". J. Biol. Chem. 241: 3262-3269. PMID 5330429. ...
The systematic name of this enzyme class is 4-deoxy-L-threo-5-hexosulose-uronate aldose-ketose-isomerase. This enzyme is also ... This enzyme belongs to the family of isomerases, specifically those intramolecular oxidoreductases interconverting aldoses and ... In enzymology, a 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase (EC 5.3.1.17) is an enzyme that catalyzes the chemical ... Preiss J (1966). "4-Deoxy-L-threo-5-hexosulose uronic acid isomerase". Carbohydrate Metabolism. Methods in Enzymology. 9. pp. ...
The mechanism that GPI uses to interconvert glucose 6-phosphate and fructose 6-phosphate (aldose to ketose) consists of three ... Glucose-6-phosphate isomerase (GPI), alternatively known as phosphoglucose isomerase (PGI) or phosphohexose isomerase (PHI), is ... Glucose-6-phosphate isomerase in PROSITE Phosphoglucose Isomerase Glucose phosphate isomerase deficiency This article ... Swan MK, Hansen T, Schonheit P, Davies C (September 2004). "A novel phosphoglucose isomerase (PGI)/phosphomannose isomerase ...
Meyerhoff and Junowicz found that the equilibrium constant for the isomerase and aldoses reaction were not affected by ... a ketose), and glyceraldehyde 3-phosphate (an aldose). There are two classes of aldolases: class I aldolases, present in ... G6P is then rearranged into fructose 6-phosphate (F6P) by glucose phosphate isomerase. Fructose can also enter the glycolytic ... Triosephosphate isomerase rapidly interconverts dihydroxyacetone phosphate with glyceraldehyde 3-phosphate (GADP) that proceeds ...
Meyerhoff and Junowicz found that the equilibrium constant for the isomerase and aldoses reaction were not affected by ... a ketose), and glyceraldehyde 3-phosphate (an aldose). There are two classes of aldolases: class I aldolases, present in ... Cofactors: Mg2+ G6P is then rearranged into fructose 6-phosphate (F6P) by glucose phosphate isomerase. Fructose can also enter ... The reaction requires an enzyme, phosphohexose isomerase, to proceed. This reaction is freely reversible under normal cell ...
Aldose · Ketose · Furanose · Pyranose. Geometry. Cyclohexane conformation · Anomer · Mutarotation. Monosaccharides. Dioses. ... Glucose-6-phosphate isomerase ഫ്രക്ടോസ് 6-ഫോസ്ഫേറ്റ് phosphofructokinase-1 Fructose 1,6-bisphosphate Fructose-bisphosphate ... Triosephosphate isomerase Glyceraldehyde 3-phosphate Glyceraldehyde-3-phosphate dehydrogenase 1,3-Bisphosphoglycerate ...
Aldose-Ketose Isomerases); EC 5.3.1.12 (glucuronate isomerase); SY7Q814VUP (Calcium). ... Aldose-Ketose Isomerases); EC 5.3.1.12 (glucuronate isomerase). ... Aldose-Cetose Isomerases/qu mica. Bioqu mica/m todos. ... Aldose-Cetose Isomerases. Escherichia coli/gen tica. Regula o da Express o G nica. Genes Reguladores. cidos Hexur nicos/ ... The isomerase was found to be inhibited by EDTA and to be stimulated by Zn(2+), Co(2+), and Mn(2+), but not by Mg(2+) or Ca(2+ ...
Putative tagatose-6-phosphate ketose/aldose isomerase 4.1. 0.001. SpnNT_00089. agaC_1 ...
The systematic name of this enzyme class is D-xylose aldose-ketose-isomerase. Other names in common use include D-xylose ... specifically those intramolecular oxidoreductases interconverting aldoses and ketoses. The isomerase has now been observed in ... Xylose-isomerases are also commonly called fructose-isomerases due to their ability to interconvert glucose and fructose. ... isomerase, D-xylose ketoisomerase, and D-xylose ketol-isomerase. The activity of D-xylose isomerase was first observed by ...
Aldose-ketose isomerases .... Apis mellifera, Ascaris suum, Bos taurus, Cavia porcellus, Homo sapiens, Klebsiella aerogenes, ... mannose-6-phosphate isomerase activity is abolished by deletion of the C-terminal 14 residues. The N-terminal region plays an ... mannose-6-phosphate isomerase activity is abolished by deletion of the C-terminal 14 residues. The N-terminal region plays an ... bifunctional enzyme with mannose-6-phosphate isomerase and sugar-1-phosphate nucleotidylyltransferase activities, EC 5.3.1.8 ...
Aldose-ketose isomerases .... Apis mellifera, Ascaris suum, Bos taurus, Cavia porcellus, Homo sapiens, Klebsiella aerogenes, ... Characterization of the Aspergillus fumigatus phosphomannose isomerase Pmi1 and its impact on cell wall synthesis and ...
The systematic name of this enzyme class is hydroxypyruvate aldose-ketose-isomerase. This enzyme participates in glyoxylate and ... This enzyme belongs to the family of isomerases, specifically those intramolecular oxidoreductases interconverting aldoses and ... de Windt FE, van der Drift C (1980). "Purification and some properties of hydroxypyruvate isomerase of Bacillus fastidiosus". ... In enzymology, a hydroxypyruvate isomerase (EC 5.3.1.22) is an enzyme that catalyzes the chemical reaction hydroxypyruvate ⇌ {\ ...
Putative tagatose-6-phosphate ketose/aldose isomerase 4.1. 0.001. SpnNT_00089. agaC_1 ...
The systematic name of this enzyme class is 11-deoxycorticosterone aldose-ketose-isomerase. Martin KO, Oh SW, Lee HJ, Monder C ... This enzyme belongs to the family of isomerases, specifically those intramolecular oxidoreductases interconverting aldoses and ... In enzymology, a corticosteroid side-chain-isomerase (EC 5.3.1.21) is an enzyme that catalyzes the chemical reaction 11- ... Monder C, Martin KO, Bogumil J (1980). "Presence of epimerase activity in hamster liver corticosteroid side chain isomerase". J ...
tagatose-6-phosphate ketose/aldose isomerase. agaV (plu0835). PTS-system, N-acetylgalactosamine-specific IIB component 2 (EIIB- ...
intramolecular isomerase activity, interconverting aldoses and ketoses. 0.016. phosphagen metabolism. 0.016. neurofilament ...
... peptidylprolyl isomerase [EC:5.2.1.8] K02082 agaS; tagatose-6-phosphate ketose/aldose isomerase [EC:5.-.-.-] K02558 mpl; UDP-N- ... VV2_1023 Putative tagatose-6-phosphate ketose/aldose isomerase VV1_0706 mpl; UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- ... VV2_0526 FKBP-type peptidyl-prolyl cis-trans isomerase / Macrophage infectivity potentiator ...
Aldose-Ketose Isomerases. MESH. Amino Acid Sequence. MESH. Binding Sites. MESH. Carbohydrate Epimerases/chemistry. MESH. ... Crystal structure at 2.0 A resolution of phosphoribosyl anthranilate isomerase from the hyperthermophile Thermotoga maritima: ... To this end the crystal structure of dimeric phosphoribosyl anthranilate isomerase from the hyperthermophile Thermotoga ... To this end the crystal structure of dimeric phosphoribosyl anthranilate isomerase from the hyperthermophile Thermotoga ...
Aldose-Ketose Isomerases. MESH. Amino Acid Sequence. MESH. Bacterial Proteins/genetics. MESH. ... phosphoribosyl anthranilate isomerase) and trpA (alpha-subunit of tryptophan synthase) suggest that these thermostable (beta ...
SIS domains (2) are commonly found in aldose-ketose isomerases and are believed to be the portion of the protein responsible ... coli A5P isomerases. When aligned individually with the SIS domains of the other three A5P isomerases, the c3406 protein shares ... isomerases (see below). A5P isomerases catalyze the interconversion of d-ribulose 5-phosphate (Ru5P), a product of the pentose ... and encodes an A5P isomerase (15) that is involved in the metabolism of sorbitol. A third A5P isomerase is found in E. coli ...
Alcohol Dehydrogenase/genetics, Aldehyde Oxidoreductases/genetics, Aldose-Ketose Isomerases/genetics, Animals, Bacterial ... glucosamine-6-phosphate isomerase, and alcohol dehydrogenase E. These four genes have a limited distribution among sequenced ...
Collyer CA, Henrick K, Blow DM (1990) Mechanism for aldose-ketose interconversion by D-xylose isomerase involving ring opening ... Carrell HL, Glusker JP, Burger V, Manfre F, Tritsch D, Biellmann JF (1989) X-ray analysis of D-xylose isomerase at 1.9 A: ... Carrell HL, Hoier H, Glusker JP (1994) Modes of binding substrates and their analogues to the enzyme D-xylose isomerase. Acta ... Yoshida H, Yoshihara A, Teraoka M, Yamashita S, Izumori K, Kamitori S (2012) Structure of L-rhamnose isomerase in complex with ...
GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses Cellular Component. No terms assigned in ... KduI/IolB isomerase (IPR021120). Short name: KduI/IolB_isomerase Family relationships *KduI/IolB isomerase (IPR021120) *5-deoxy ... The KduI/IolB family of enzymes includes 5-keto 4-deoxyuronate isomerase (KduI) and 5-deoxy-glucuronate isomerase (IolB). ... The crystal structure of 5-keto-4-deoxyuronate isomerase from Escherichia coli.. Proteins 61 680-4 2005 ...
The food enzyme is a d‐xylose aldose‐ketose‐isomerase (EC 5.3.1.5) produced with the genetically modified Streptomyces ... Safety evaluation of the food enzyme xylose isomerase from the genetically modified Streptomyces rubiginosus strain DP‐Pzn37. ...
They include enzymes converting aldoses to ketoses (ALDOSE-KETOSE ISOMERASES), enzymes shifting a carbon-carbon double bond ( ... CARBON-CARBON DOUBLE BOND ISOMERASES), and enzymes transposing S-S bonds (SULFUR-SULFUR BOND ISOMERASES). (From Enzyme ... Enzymes of the isomerase class that catalyze the oxidation of one part of a molecule with a corresponding reduction of another ... Carbon-carbon Double Bond Isomerases. Enzymes that catalyze the shifting of a carbon-carbon double bond from one position to ...
Purchase high purity enzyme Phosphoglucose isomerase (S. cerevisiae) for use in research, biochemical enzyme assays and in ... glucose-6-phosphate isomerise; D-glucose-6-phosphate aldose-ketose-isomerase. Recombinant. From Saccharomyces cerevisiae.. In ... High purity Phosphoglucose isomerase (Saccharomyces cerevisiae) for use in research, biochemical enzyme assays and in vitro ... One unit of phosphoglucose isomerase activity is the amount of enzyme required to convert one µmole of D-fructose 6-phosphate ...
Aldose-Ketose Isomerases. 3. + +. 76. Isocitrate Lyase. 3. + +. 77. Quinine. 3. + +. 78. Polymyxin B. 3. + +. ...
... measurements of phosphoglucose isomerase and phosphomannose isomerase by direct analysis of phosphorylated aldose-ketose ... Wierenga RK, Kapetaniou EG, Venkatesan R. Triosephosphate isomerase: a highly evolved biocatalyst. Cell Mol Life Sci. 2010;67( ... First, among the 17 enzyme-constrained reactions, we identified triose-phosphate isomerase (TPI), glyceraldehyde-3-phosphate ... for which the glucose-6-phosphate isomerase (PGI), MDH, glucose 6-phosphate dehydrogenase (G6PDH), succinate dehydrogenase ( ...
... measurements of phosphoglucose isomerase and phosphomannose isomerase by direct analysis of phosphorylated aldose-ketose ... Induction of aldose reductase and xylitol dehydrogenase activities in Candida tenuis CBS 4435. FEMS Microbiol Lett. 1997;149(1 ... Development of efficient xylose fermentation in Saccharomyces cerevisiae: xylose isomerase as a key component. Adv Biochem Eng ... Time-dependent utilization of NADPH (XR) or NADH [XR, alcohol dehydrogenase (ADH), XK, phosphoglucose isomerase (PGI), 6- ...
... that were shown to provide xylose isomerase activity in yeast cells. The xylose isomerase activity can complete a xylose ... C12Y503/01-Intramolecular oxidoreductases (5.3) interconverting aldoses and ketoses (5.3.1) * C12Y503/01005-Xylose isomerase ( ... Xylose Isomerase. Expression of xylose isomerases in yeast cells has been problematic; in particular, many bacterial xylose ... US8906656B2 - Cow rumen xylose isomerases active in yeast cells - Google Patents. Cow rumen xylose isomerases active in yeast ...
Aldose-Ketose Isomerases. Grant support. *R01 GM068440/GM/NIGMS NIH HHS/United States ...
Phosphoglucose isomeraseKetol-isomeraseTriose-phosphateMannose-6-phosphate isomerSugar isomerasePentose-5-phosphate isomeraseEscherichiaRibose-5-phosphaArabinose 5-phosphaFructose 6-phosphaIsomerizationEnzymesRecombinantInterconvertingEnzyme classMechanismXylose isomerasesIsomersInterconversionMonosaccharide that containsMetabolismStreptomycesDehydrogenaseCarbon atomsDivalentPutativeSugarsMolecule1.27GlyceraldehydeActivity
- High purity Phosphoglucose isomerase ( Saccharomyces cerevisiae ) for use in research, biochemical enzyme assays and in vitro diagnostic analysis. (megazyme.com)
- One unit of phosphoglucose isomerase activity is the amount of enzyme required to convert one µmole of D-fructose 6-phosphate to D-glucose 6-phosphate at pH 7.6. (megazyme.com)
- Intramolecular hydrogen transfer in the phosphoglucose isomerase reaction. (moonlightingproteins.org)
- The differentiation and maturation mediator for human myeloid leukemia cells shares homology with neuroleukin or phosphoglucose isomerase. (moonlightingproteins.org)
- Following this the glucose6-phosphate (aldose) is converted into ketose-6-phosphate (ketose) by an isomerisation reaction that is catalysed by phosphoglucose isomerase. (oxbridgenotes.co.uk)
- Phosphoglucoisomerase (alternatively known as phosphoglucose isomerase or Glucose-6-phosphate isomerase ) are a group of enzymes of the isomerase family ( EC 5.3.1.9), so named for their main function in glycolysis and gluconeogenesis. (proteopedia.org)
- In both these pathways phosphoglucose isomerase (PGI) is used to inter-convert glucose-6-phosphate and fructose 6-phosphate. (proteopedia.org)
- of phosphoglucose isomerase is charaterized by an αβα conformation, on each of its two domains. (proteopedia.org)
- Phosphoglucose isomerase has a monomer molecular mass of proximately 55 kDa. (proteopedia.org)
- Another characteristic of phosphoglucose isomerase is that binding of substrate at the active site induces a small movement in the conformation of the enzyme. (proteopedia.org)
- Other names in common use include D-xylose isomerase, D-xylose ketoisomerase, and D-xylose ketol-isomerase. (wikipedia.org)
- DHAP (ketose) is isomerized to G3-P (aldose) only G3-P can go through the rest of the pathway triose phosphate isomerase why? (docplayer.net)
- mannose-6-phosphate isomerase activity is abolished by deletion of the C-terminal 14 residues. (brenda-enzymes.org)
- Analysis of this gene cluster reveals that one of the genes, c3406, encodes a protein with significant homology to the sugar isomerase (SIS) domain of arabinose 5-phosphate (A5P) isomerases (see below). (asm.org)
- The sugar isomerase (SIS) domain is a phosphosugar-binding module that is found in a variety of eubacterial, archaebacterial and eukaryotic proteins that have a role in phosphosugar isomerization or regulation [ 1 ]. (expasy.org)
- Finally, the enzyme pentose-5-phosphate isomerase, by an intermediary enediol, isomerizes the ribulose 5-phosphate and converts ribose-5-phosphate to the transformation of the group ketose in aldose. (biochemden.com)
- At last, the compound pentose-5-phosphate isomerase, by a mediator enediol, isomerizes the ribulose 5-phosphate and changes over ribose-5-phosphate to the change of the gathering ketose in aldose. (androbose.in)
- A spectrophotometric assay of D-glucuronate based on Escherichia coli uronate isomerase and mannonate dehydrogenase. (bireme.br)
- Escherichia coli uronate isomerase and mannonate dehydrogenase were overexpressed in E. coli BL21(DE3)pLysS cells and purified to near-homogeneity. (bireme.br)
- The crystal structure of 5-keto-4-deoxyuronate isomerase from Escherichia coli. (ebi.ac.uk)
- 3. Korndorfer, I.P., Fessner, W.D. and Matthews, B.W. The structure of rhamnose isomerase from Escherichia coli and its relation with xylose isomerase illustrates a change between inter and intra-subunit complementation during evolution. (qmul.ac.uk)
- Escherichia coli arabinose 5-phosphate isomerase (kdsD) (EC 5.3.1.13 ). (expasy.org)
- Crystal structure of YihS in complex with D-mannose: structural annotation of Escherichia coli and Salmonella enterica yihS-encoded proteins to an aldose-ketose isomerase. (tapedawn.top)
- Here we reported that a Drosophila strain with reduced expression of ribose-5-phosphate isomerase (rpi), EP2456, exhibits increased resistance to oxidative stress and enhanced lifespan. (isharonline.org)
- We prepared recombinant c3406 protein, found it to possess arabinose 5-phosphate isomerase activity, and characterized this activity in detail. (asm.org)
- Thus, CtAPI represents the first d -arabinose-5-phosphate isomerase to be identified and characterized from a Gram-positive bacterium. (asm.org)
- Then, it is converted to fructose-6-phosphate by mannose phosphate isomerase . (wikidoc.org)
- l-Rhamnose isomerase (l-RhI) catalyzes the reversible isomerization of l-rhamnose to l-rhamnulose. (tailieu.vn)
- The basic mechanism involves the isomerization of an aldose to a ketose. (proteopedia.org)
- Xylose isomerase enzymes exhibit a TIM barrel fold with the active site in the centre of the barrel and a tetrameric quaternary structure. (wikipedia.org)
- The KduI/IolB family of enzymes includes 5-keto 4-deoxyuronate isomerase (KduI) and 5-deoxy-glucuronate isomerase (IolB). (ebi.ac.uk)
- Chemistry of proton abstraction by glycolytic enzymes (aldolase, isomerases and pyruvate kinase). (moonlightingproteins.org)
- In enzymes, the SIS domain can have a catalytic function as an isomerase and bind to phosphorylated sugars. (expasy.org)
- The recombinant xylose isomerase showed the highest activity at 85 degrees C with a specific activity of 1.0 U mg-1. (lu.se)
- This enzyme belongs to the family of isomerases, specifically those intramolecular oxidoreductases interconverting aldoses and ketoses. (wikipedia.org)
- The systematic name of this enzyme class is D-xylose aldose-ketose-isomerase. (wikipedia.org)
- The systematic name of this enzyme class is hydroxypyruvate aldose-ketose-isomerase. (wikipedia.org)
- Collyer CA, Henrick K, Blow DM (1990) Mechanism for aldose-ketose interconversion by D-xylose isomerase involving ring opening followed by a 1,2-hydride shift. (springer.com)
- Mechanism of the aldose-ketose isomerase reactions. (moonlightingproteins.org)
- For the aldose-ketose isomer-ization by l-RhI, a metal-mediated hydride-shift mechanism has been proposed, but the catalytic mechanism is still not entirely understood. (tailieu.vn)
- The tertiary structure was determined for several xylose isomerases from microbes starting in the mid 1980s (Streptomyces olivochromogenes in 1988, Streptomyces violaceoniger in 1988, Streptomyces rubiginosus in 1984, Arthrobacter B3728 in 1986, Actinoplanes missouriensis in 1992, and Clostridium thermosulfurogenes in 1990). (wikipedia.org)
- Furthermore, the results showed that the real equilibrium of XI catalyzed reactions is not between two isomers but between a ketose and its two aldose isomers. (aalto.fi)
- A5P isomerases catalyze the interconversion of d -ribulose 5-phosphate (Ru5P), a product of the pentose phosphate pathway, and A5P, an important intermediate in LPS and capsular polysaccharide biosynthesis ( 25 ). (asm.org)
- d -Arabinose-5-phosphate (A5P) isomerases (APIs) catalyze the interconversion of d -ribulose-5-phosphate and d -arabinose-5-phosphate. (asm.org)
- In Gram-negative microorganisms, d -arabinose-5-phosphate (A5P) isomerase (API) catalyzes the interconversion of d -ribulose-5-phosphate (Ru5P), a product of the pentose phosphate pathway, and d -arabinose-5-phosphate. (asm.org)
- Aldose is a monosaccharide that contains an aldehyde group. (dansukker.com)
- The gutQ gene is found in the glucitol operon ( gutAEBDMRQ ) and encodes an A5P isomerase ( 15 ) that is involved in the metabolism of sorbitol. (asm.org)
- In the present study novel tetrose isomerizations and C-2 epimerizations with both the D- and L-forms of the sugars by an industrial xylose isomerase (XI) from Streptomyces rubiginosus were described. (aalto.fi)
- Here we present gene distribution and phylogenetic analyses of the genes encoding the hybrid-cluster protein, A-type flavoprotein, glucosamine-6-phosphate isomerase, and alcohol dehydrogenase E. These four genes have a limited distribution among sequenced prokaryotic and eukaryotic genomes and were previously implicated in gene transfer events affecting eukaryotes. (diva-portal.org)
- As a matter of convenience, however, the different isomerases have been ordered in this chapter according to the number of carbon atoms in the carbohydrates on which they act. (springer.com)
- Thermal tests were also done by Kei Y. and Noritaka T. and the xylose isomerase was found to be thermally stable to about 60 degrees Celsius Xylose isomerase has a structure that is based on eight alpha/beta barrels that create an active site holding two divalent magnesium ions. (wikipedia.org)
- Bacterial putative tagatose-6-phosphate ketose/aldose isomerase (agaS) (EC 5.3.1. (expasy.org)
- Crystal structure of a putative tagatose-6-phosphate ketose/aldose isomerase (NT01CX_0292) from CLOSTRIDIUM NOVYI NT at 2.35 A resolution. (burnham.org)
- Hence D-xylose isomerase is used to produce these rare sugars which have very important applications in biology despite their low abundance. (wikipedia.org)
- Fructose 1,6, phosphate is then formed by the phosphorylation of ketose-6-phosphate, which is the committed step, and this molecule is cleaved into a three carbon compound glyceraldehyde-3-phosphate. (oxbridgenotes.co.uk)
- Prokaryotic 3-hexulose-6-phosphate isomerase (PHI) (EC 5.3.1.27 ). (expasy.org)
- Structures for the D and L isomer of the simplest aldose, glyceraldehyde, are shown below. (purdue.edu)
- The activity of D-xylose isomerase was first observed by Mitsuhashi and Lampen in 1953 in the bacterium Lactobacillus pentosus. (wikipedia.org)