Aldehyde Oxidase
An aldehyde oxidoreductase expressed predominantly in the LIVER; LUNGS; and KIDNEY. It catalyzes the oxidation of a variety of organic aldehydes and N-heterocyclic compounds to CARBOXYLIC ACIDS, and also oxidizes quinoline and pyridine derivatives. The enzyme utilizes molybdenum cofactor and FAD as cofactors.
Xanthine Oxidase
Aldehyde Dehydrogenase
Xanthine Dehydrogenase
NADPH Oxidase
A flavoprotein enzyme that catalyzes the univalent reduction of OXYGEN using NADPH as an electron donor to create SUPEROXIDE ANION. The enzyme is dependent on a variety of CYTOCHROMES. Defects in the production of superoxide ions by enzymes such as NADPH oxidase result in GRANULOMATOUS DISEASE, CHRONIC.
Molybdenum
Pteridines
Coenzymes
Liver
Oxidation-Reduction
A chemical reaction in which an electron is transferred from one molecule to another. The electron-donating molecule is the reducing agent or reductant; the electron-accepting molecule is the oxidizing agent or oxidant. Reducing and oxidizing agents function as conjugate reductant-oxidant pairs or redox pairs (Lehninger, Principles of Biochemistry, 1982, p471).
Monoamine Oxidase
An enzyme that catalyzes the oxidative deamination of naturally occurring monoamines. It is a flavin-containing enzyme that is localized in mitochondrial membranes, whether in nerve terminals, the liver, or other organs. Monoamine oxidase is important in regulating the metabolic degradation of catecholamines and serotonin in neural or target tissues. Hepatic monoamine oxidase has a crucial defensive role in inactivating circulating monoamines or those, such as tyramine, that originate in the gut and are absorbed into the portal circulation. (From Goodman and Gilman's, The Pharmacological Basis of Therapeutics, 8th ed, p415) EC 1.4.3.4.
Allopurinol
Metalloproteins
Protein-Lysine 6-Oxidase
Oxidoreductases
The class of all enzymes catalyzing oxidoreduction reactions. The substrate that is oxidized is regarded as a hydrogen donor. The systematic name is based on donor:acceptor oxidoreductase. The recommended name will be dehydrogenase, wherever this is possible; as an alternative, reductase can be used. Oxidase is only used in cases where O2 is the acceptor. (Enzyme Nomenclature, 1992, p9)
Species Specificity
The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.
Drosophila melanogaster
PubMed
A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.
Drosophila
Drosophila Proteins
Gene Expression Profiling
Manduca
Pheromones
Biotin
Xanthine
A purine base found in most body tissues and fluids, certain plants, and some urinary calculi. It is an intermediate in the degradation of adenosine monophosphate to uric acid, being formed by oxidation of hypoxanthine. The methylated xanthine compounds caffeine, theobromine, and theophylline and their derivatives are used in medicine for their bronchodilator effects. (Dorland, 28th ed)
Chloromercurinitrophenols
Quinolones
Isocarboxazid
Biotransformation
The chemical alteration of an exogenous substance by or in a biological system. The alteration may inactivate the compound or it may result in the production of an active metabolite of an inactive parent compound. The alterations may be divided into METABOLIC DETOXICATION, PHASE I and METABOLIC DETOXICATION, PHASE II.
Microsomes, Liver
Alkynes
Palladium
Rhodium
Cyclization
Aldehyde oxidase-dependent marked species difference in hepatic metabolism of the sedative-hypnotic, zaleplon, between monkeys and rats. (1/144)
A marked difference in hepatic activity of aldehyde oxidase between rats and monkeys was found to be responsible for the previously reported marked species difference in the metabolism of Zaleplon in vivo. In the postmitochondrial fractions, S-9s, from liver homogenates of these animals, Zaleplon was transformed in the presence of NADPH into the side chain oxidation product, N-desethyl-Zaleplon, and the aromatic ring oxidation product, 5-oxo-Zaleplon. In the rat S-9, N-desethyl-Zaleplon and 5-oxo-Zaleplon were a major and a very minor metabolites, respectively. However, in the monkey S-9, Zaleplon was transformed into 5-oxo-Zaleplon at a much higher rate than that for N-desethyl-Zaleplon formation. N-Desethyl-Zaleplon was formed in the monkey S-9 at a rate almost equal to that in the rat S-9. N-Desethyl-5-oxo-Zaleplon was formed at a minor rate only in the monkey S-9 through N-desethyl-Zaleplon as an obligatory intermediate. The hepatic activity for the formation of 5-oxo-Zaleplon in the monkey and rat was localized in cytosol and did not require NADPH. Sensitivity to various inhibitors and requirement of water as oxygen source, using H218O, strongly suggested that the hepatic cytosolic formation of 5-oxo-Zaleplon was mediated by aldehyde oxidase. N-Desethyl-Zaleplon was formed in the presence of NADPH by microsomes from the liver of rats and monkeys, and its formation was strongly suggested using various cytochrome P-450 inhibitors to be mediated by a number of cytochrome P-450 isoforms, such as 3A, 2C, and 2D subfamilies. (+info)A genetic linkage map of rat chromosome 9 with a new locus for variant activity of liver aldehyde oxidase. (2/144)
A genetic linkage map of rat chromosome 9 consisting of five loci including a new biochemical marker representing a genetic variation of the activity of the liver aldehyde oxidase, (Aox) was constructed. Linkage analysis of the five loci among 92 backcross progeny of (WKS/Iar x IS/Iar)F1 x WKS/Iar revealed significant linkages between these loci. Minimizing crossover frequency resulted in the best gene order: Aox-D9Mit4-Gls-Cryg-Tp53l1. The homologues of the Cryg, Gls, and Aox genes have been mapped on mouse chromosome 1 and human chromosome 2q. The present findings provide further evidence for the conservation of synteny among these regions of rat, mouse, and human chromosomes. (+info)Molecular cloning of the cDNA coding for mouse aldehyde oxidase: tissue distribution and regulation in vivo by testosterone. (3/144)
The cDNA coding for mouse aldehyde oxidase (AO), a molybdoflavoprotein, has been isolated and characterized. The cDNA is 4347 nt long and consists of an open reading frame predicting a polypeptide of 1333 amino acid residues, with 5' and 3' untranslated regions of 13 and 335 nt respectively. The apparent molecular mass of the translation product in vitro derived from the corresponding cRNA is consistent with that of the monomeric subunit of the AO holoenzyme. The cDNA codes for a catalytically active form of AO, as demonstrated by transient transfection experiments conducted in the HC11 mouse mammary epithelial cell line. The deduced primary structure of the AO protein contains consensus sequences for two distinct 2Fe-2S redox centres and a molybdopterin-binding site. The amino acid sequence of the mouse AO has a high degree of similarity with the human and bovine counterparts, and a significant degree of relatedness to AO proteins of plant origin. Northern blot and in situ hybridization analyses demonstrate that hepatocytes, cardiocytes, lung endothelial or epithelial cells and oesophagus epithelial cells express high levels of AO mRNA. In the various tissues and organs considered, the level of AO mRNA expression is not strictly correlated with the amount of the corresponding protein, suggesting that the synthesis of the AO enzyme is under translational or post-translational control. In addition, we observed sex-related regulation of AO protein synthesis. In the liver of male animals, despite similar amounts of AO mRNA, the levels of the AO enzyme and corresponding polypeptide are significantly higher than those in female animals. Treatment of female mice with testosterone increases the amounts of AO mRNA and of the relative translation product to levels similar to those in male animals. (+info)Production of homo- and hetero-dimeric isozymes from two aldehyde oxidase genes of Arabidopsis thaliana. (4/144)
Polyclonal antibodies were raised against synthetic peptides or recombinant polypeptides encoded by Arabidopsis atAO-1 and atAO-2 cDNAs, which have sequences similar to maize and animal aldehyde oxidase (AO) cDNAs. Anti-atAO-1 antibodies recognized AOalpha and AObeta among the three isoforms, AOalpha, AObeta, and AOgamma, detected in Arabidopsis seedlings after native PAGE, while anti-atAO-2 antibodies reacted with AObeta and AOgamma. The polypeptide specifically recognized by each antibody was collected as the Protein-A/IgG/antigen complex. The 150- and 145-kDa polypeptides were purified by SDS-PAGE and digested with Achromobacter Protease I. From the amino acid sequences and molecular masses of the derivative peptides, it was revealed that the 150- and 145-kDa polypeptides were the products of atAO-1 and atAO-2, respectively. Molecular masses of the native forms of AOalpha, AObeta, and AOgamma were estimated as approximately 290-300 kDa. These results suggest that AOalpha and AOgamma are homodimers consisting of atAO-1 and atAO-2 products, respectively, and that AObeta is a heterodimer of the atAO-1 and atAO-2 products. (+info)Thioguanine administered as a continuous intravenous infusion to pediatric patients is metabolized to the novel metabolite 8-hydroxy-thioguanine. (5/144)
Thiopurine antimetabolites have been in clinical use for more than 40 years, yet the metabolism of thiopurines remains only partially understood. Data from our previous pediatric phase 1 trial of continuous i.v. infusion of thioguanine (CIVI-TG) suggested that TG was eliminated by saturable mechanism, with conversion of the drug to an unknown metabolite. In this study we have identified this metabolite as 8-hydroxy-thioguanine (8-OH-TG). The metabolite coeluted with the 8-OH-TG standard on HPLC and had an identical UV spectrum, with a lambda(max) of 350 nm. On mass spectroscopy, the positive ion, single quad scan of 8-OH-TG yielded a protonated molecular ion at 184 Da and contained diagnostic ions at m/z 167, 156, 142, and 125 Da. Incubation of TG in vitro with partially purified aldehyde oxidase resulted in 8-OH-TG formation. 8-OH-TG is the predominant circulating metabolite found in patients receiving CIVI-TG and is likely generated by the action of aldehyde oxidase. (+info)The mouse aldehyde oxidase gene: molecular cloning, chromosomal mapping and functional characterization of the 5'-flanking region. (6/144)
In this article, we report on the chromosome mapping and molecular cloning of the genetic locus encoding the mouse molybdo-iron/sulfur-flavoprotein aldehyde oxidase. The aldehyde oxidase locus maps to mouse chromosome 1 band C1-C2, as determined by fluorescence in situ hybridization experiments conducted on metaphase chromosomes. The gene is approximately 83 kb long and consists of 35 exons. The exon/intron boundaries are perfectly conserved relative to the corresponding human homolog and almost completely conserved relative to the mouse xanthine oxidoreductase gene. This further supports the concept that the aldehyde oxidase and xanthine oxidoreductase loci evolved from the same ancestral precursor by a gene duplication event. The position of a major transcription start site was defined by primer extension and RNase mapping analysis. The 5'-flanking region of the mouse aldehyde oxidase gene contains a functional and orientation-dependent promoter as well as several putative binding sites for known cell-specific and general transcription factors. Deletion analysis of the 5'-flanking region defines an approximately 470 bp DNA stretch which is necessary and sufficient for the transcription of the mouse aldehyde oxidase gene. (+info)Functional expression of two Arabidopsis aldehyde oxidases in the yeast Pichia pastoris. (7/144)
To investigate the biochemical and enzymatic properties of two aldehyde oxidase (AO) isoforms of Arabidopsis thaliana, we expressed AAO1 and AAO2 cDNAs in a heterologous yeast (Pichia pastoris) system and successfully obtained the proteins in active forms. The expressed AAO1 and AAO2 proteins gave activity bands with the same mobilities on native gel electrophoresis and exhibited the same substrate preferences on zymograms with 8 aldehydes as those of AOalpha and AOgamma in Arabidopsis seedlings, respectively. Furthermore, anti-AAO1 and anti-AAO2 antibodies, which specifically recognize the seedling AOalpha and AOgamma, respectively, reacted with the AAO1 and AAO2 proteins produced in P. pastoris, respectively. These results indicate that these AO proteins are accurately produced in the yeast system, as in Arabidopsis seedlings. Using AO preparations from P. pastoris, the enzymatic properties of Arabidopsis AOalpha and AOgamma were investigated. AOalpha showed a relatively wide substrate specificity for 7 aldehydes tested, with high affinity to benzaldehyde and indole-3-aldehyde, while AOgamma could most efficiently oxidize naphthaldehyde. AOalpha was strongly inhibited by iodoacetate and KCN, while AOgamma was inhibited not only by iodoacetate and KCN but also by 2-mercaptethanol, dithiothreitol, menadion, and estradiol. AOalpha and AOgamma showed the highest activity at around 65 and 50 degrees C, respectively, and exhibited pH dependence around pH 8.0. These results indicate that the two AO isoforms in Arabidopsis seedlings have different enzymatic properties and may have different physiological roles in vivo. (+info)Metabolism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in perfused rat liver: involvement of hepatic aldehyde oxidase as a detoxification enzyme. (8/144)
To elucidate the toxicological relevance of hepatic aldehyde oxidase (AO) as a detoxification enzyme of 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridine (MPTP), we studied the metabolism and the hepatotoxicity of MPTP in intact rat livers exhibiting different AO activities by using a recirculating perfusion method. In the perfusate during a 90-min recirculation of 1 mM MPTP, the perfused liver from Jcl:Wistar rat, a strain showing high AO activity, generated almost equal amounts of 1-methyl-4-phenylpyridinium species (MPP(+)) and 1-methyl-4-phenyl-5,6-dihydro-2-pyridone (MPTP lactam) as major metabolites, together with 4-phenyl-1,2,3, 6-tetrahydropyridine, 1-methyl-4-phenyl-2-pyridone (MP 2-pyridone) and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine N-oxide. However, a marked decrease of MPTP lactam as well as MP 2-pyridone and a concomitant increase of MPP(+) were caused by coinfusion of 2-hydroxypyrimidine (2-OH PM), a competitive inhibitor of AO, into Jcl:Wistar rat liver. A quite similar metabolic profile was obtained on perfusion of AO-deficient WKA/Sea rat liver. Rather large amounts of MPP(+) were retained in the liver in all cases, but especially in Jcl:Wistar rat in the presence of 2-OH PM. Lactate dehydrogenase leakage into the perfusate from rat liver perfused with 1 mM MPTP was greater in the strain with lower AO activity, WKA/Sea, than in that with higher AO activity, Jcl:Wistar. Furthermore, inhibition of AO in Jcl:Wistar rat in the presence of 2-OH PM caused an enhancement of lactate dehydrogenase leakage. These results suggest that hepatic AO is a key detoxification enzyme for MPTP. (+info)
Aldehyde oxidase 1 - Wikipedia
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Alkanal monooxygenase (FMN-linked)
Hastings JW, Presswood RP (1978). "Bacterial luciferase: FMNH2-aldehyde oxidase". Methods Enzymol. Methods in Enzymology. 53: ... aldehyde monooxygenase, luciferase, and Vibrio fischeri luciferase. As of late 2007, 4 structures have been solved for this ... "Bacterial bioluminescence light emission in the mixed function oxidation of reduced flavin and fatty aldehyde". CRC Crit. Rev. ...
Acetaldehyde dehydrogenase
Aldehyde oxidase. 1.2.4: disulfide. *Oxoglutarate dehydrogenase complex. *Pyruvate dehydrogenase. *Branched-chain alpha-keto ... Wang X, Weiner H (Jan 1995). "Involvement of glutamate 268 in the active site of human liver mitochondrial (class 2) aldehyde ... Crabb D, Xiao Q (Jun 1998). "Studies on the enzymology of aldehyde dehydrogenase-2 in genetically modified HeLa cells". ... Hempel J, von Bahr-Lindström H, Jörnvall H (May 1984). "Aldehyde dehydrogenase from human liver. Primary structure of the ...
BCKDHA
Aldehyde oxidase. 1.2.4: disulfide. *Oxoglutarate dehydrogenase complex. *Pyruvate dehydrogenase. *Branched-chain alpha-keto ... oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor. • protein binding. • metal ion ...
Ziprasidone
... is hepatically metabolized by aldehyde oxidase; minor metabolism occurs via cytochrome P450 3A4 (CYP3A4). ...
Oxidoreductase
aldehyde oxidase Ja 1.2.4.1 pyruvate dehydrogenase (acetyl-transferring) Ja 1.2.4.2 oxoglutarate dehydrogenase (succinyl- ... Aldehyde of keton + NADH + H+ Alcoholdehydrogenase (NAD+) Ja 1.1.1.2 Alcohol + NADP+ ⇌. {\displaystyle \rightleftharpoons }. ... Aldehyde + NADPH + H+ Alcoholdehydrogenase (NADP+) Ja 1.1.1.3 L-Homoserine + NAD(P)+ ⇌. {\displaystyle \rightleftharpoons }. L- ... cytochroom-c-oxidase Ja Externe links[bewerken , brontekst bewerken]. *Integrated Enzyme Database (European Bioinformatics ...
Isovanillin
It is a selective inhibitor of aldehyde oxidase. It is not a substrate of that enzyme, and is metabolized by aldehyde ... Isovanillin is a phenolic aldehyde, an organic compound and isomer of vanillin. ... Isovanillin and Protocatechuic Aldehyde with Freshly Prepared Guinea Pig Liver Slices". Cell Physiol Biochem. 15 (1-4): 89-98. ...
Lenvatinib
M2 and lenvatinib itself are oxidized by aldehyde oxidase (AO) to substances called M2' and M3', the main metabolites in the ... "Oxidative metabolic pathway of lenvatinib mediated by aldehyde oxidase". Drug Metabolism and Disposition. 42 (8): 1326-33. doi: ...
Molybdenum
those enzymes include aldehyde oxidase, sulfite oxidase and xanthine oxidase. With one exception, Mo in proteins is bound by ... sulfite oxidase, xanthine oxidoreductase, aldehyde oxidase, and mitochondrial amidoxime reductase. People severely deficient in ... is catalyzed by xanthine oxidase, a molybdenum-containing enzyme. The activity of xanthine oxidase is directly proportional to ... The Relationship between Sulfite Oxidase and the Acute Toxicity of Bisulfite and SO2". Proceedings of the National Academy of ...
Serotonin
Metabolism involves first oxidation by monoamine oxidase to the corresponding aldehyde. The rate-limiting step is hydride ... These compounds do reach the brain, although some portion of them are metabolized by monoamine oxidase enzymes (mainly MAO-A) ... There follows oxidation by aldehyde dehydrogenase to 5-HIAA, the indole acetic-acid derivative. The latter is then excreted by ... Monoamine oxidase inhibitors (MAOIs) prevent the breakdown of monoamine neurotransmitters (including serotonin), and therefore ...
Metal dithiolene complex
November 1995). "Crystal structure of the xanthine oxidase-related aldehyde oxido-reductase from D. gigas". Science. 270 (5239 ...
Gamma-Aminobutyric acid
GABA can also be synthesized from putrescine by diamine oxidase and aldehyde dehydrogenase. Traditionally it was thought that ...
Allopurinol
... xanthine oxidase, but this action is principally carried out by aldehyde oxidase. The active metabolite of allopurinol is ... "Demonstration of a combined deficiency of xanthine oxidase and aldehyde oxidase in xanthinuric patients not forming oxipurinol ... and is an inhibitor of the enzyme xanthine oxidase. Xanthine oxidase is responsible for the successive oxidation of ... Allopurinol is in the xanthine oxidase inhibitor family of medications. Allopurinol was approved for medical use in the United ...
Molybdenum cofactor sulfurtransferase
"ABA3 is a molybdenum cofactor sulfurase required for activation of aldehyde oxidase and xanthine dehydrogenase in Arabidopsis ...
Choline
In humans, choline is oxidized irreversibly in liver mitochondria to glycine betaine aldehyde by choline oxidases. This is ... oxidized by mitochondrial or cytosolic betaine-aldehyde dehydrogenases to trimethylglycine. Trimethylglycine is a necessary ...
Molybdenum cofactor deficiency
... in molybdenum cofactor biosynthesis causes absence of enzyme activity of xanthine dehydrogenase/oxidase and aldehyde oxidase. ... Sulfite oxidase Reiss J, Johnson JL (June 2003). "Mutations in the molybdenum cofactor biosynthetic genes MOCS1, MOCS2, and ... Usually this leads to death within months of birth, due to the lack of active sulfite oxidase. Furthermore, a mutational block ...
Molybdopterin synthase
... aldehyde oxidase, and sulfite oxidase in humans. MoCo containing enzymes typically catalyze the net transfer of an oxygen atom ... xanthine oxidase, and aldehyde oxidase. Symptoms of MoCo deficiency are linked to the accumulation of toxic metabolites caused ... MoCo deficiency in humans results in the combined deficiency of the MoCo-containing enzymes: sulfite oxidase, ... by the reduced activity of these molybdoenzymes, especially sulfite oxidase. Genetic defects in MoCo biosynthesis lead to MoCo ...
Phenethylamine
... a significant amount is metabolized in the small intestine by monoamine oxidase B (MAO-B) and then aldehyde dehydrogenase (ALDH ... In humans, PEA is metabolized by phenylethanolamine N-methyltransferase (PNMT), monoamine oxidase A (MAO-A), monoamine oxidase ... Yang, HY; Neff, NH (1973). "Beta-phenylethylamine: A specific substrate for type B monoamine oxidase of brain". The Journal of ... intermediate product which is produced by monoamine oxidase and then further metabolized into β-phenylacetic acid by aldehyde ...
Fosdenopterin
... xanthine dehydrogenase/oxidase and aldehyde oxidase. Fosdenopterin was developed by José Santamaría-Araujo and Guenter Schwarz ... cPMP is a precursor to molybdopterin, which is required for the enzyme activity of sulfite oxidase, ...
Molybdopterin
... aldehyde oxidase. Prosthetic group of: formate dehydrogenase, purine hydroxylase, thiosulfate reductase. Molybdenum cofactor ... Enzymes that contain the molybdopterin cofactor include xanthine oxidase, DMSO reductase, sulfite oxidase, and nitrate ... Molybdopterin is a: Cofactor of: xanthine oxidase, DMSO reductase, sulfite oxidase, nitrate reductase, ethylbenzene ... In some enzymes, such as xanthine oxidase, the metal is bound to one molybdopterin, whereas, in other enzymes, e.g., DMSO ...
Indole-3-acetaldehyde
... aldehyde dehydrogenase family 7 member A1, amine oxidase A, aldehyde dehydrogenase 1A3 and membrane copper amine oxidase. ... amine oxidase B, amiloride-sensitive amine oxidase, aldehyde dehydrogenase (mitochondrial), fatty aldehyde dehydrogenase, 4- ... Indole-3-acetaldehyde is a substrate for retina-specific copper amine oxidase, aldehyde dehydrogenase X (mitochondrial), ... trimethylaminobutyraldehyde dehydrogenase, aldehyde dehydrogenase (dimeric NADP-preferring), ...
PCM1
... sulfite oxidase (mitochondrial precursor), aldehyde oxidase, erythropoietin receptor precursor and the ATPbinding cassette, sub ...
Drug metabolism
... monooxygenase system Flavin-containing monooxygenase system Alcohol dehydrogenase and aldehyde dehydrogenase Monoamine oxidase ... The reaction mechanism of the P-450 oxidases proceeds through the reduction of cytochrome-bound oxygen and the generation of a ... In phase I, enzymes such as cytochrome P450 oxidases introduce reactive or polar groups into xenobiotics. These modified ... One of the most common modifications is hydroxylation catalysed by the cytochrome P-450-dependent mixed-function oxidase system ...
Xanthine dehydrogenase
Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain MOCOS Xanthine oxidase GRCh38: Ensembl release 89: ... Involvement of thiol groups in the conversion of the enzyme activity from dehydrogenase (type D) into oxidase (type O) and ... Minoshima S, Wang Y, Ichida K, Nishino T, Shimizu N (1994). "Mapping of the gene for human xanthine dehydrogenase (oxidase) ( ... Rouquette M, Stevens C, Blake DR, Harrison R, Whish J, Whish WD (August 1997). "Expression of xanthine oxidase activity in ...
Zaleplon
... and its half-life can be affected by substances which inhibit or induce aldehyde oxidase. Taken orally, zaleplon reaches full ... the δ-frequency band and a decrease in the energy of the θ-frequency band Zaleplon is primarily metabolised by aldehyde oxidase ...
Glutamate decarboxylase
... and elsewhere by the actions of diamine oxidase and aldehyde dehydrogenase 1a1. Several truncated transcripts and polypeptides ... October 2015). "Aldehyde dehydrogenase 1a1 mediates a GABA synthesis pathway in midbrain dopaminergic neurons" (PDF). Science. ...
Histamine intolerance
... and aldehyde oxidases (AOX1). In histamine intolerance, the activity of DAO is limited, and histamine taken up by the diet and ... through the intestinal wall during absorption and enters the blood without coming into contact with the aldehyde oxidases ... such as diamine oxidase (DAO) and histamine N-methyltransferase (HNMT). In contrast, allergic reactions involving an immediate ... and measure changes in histamine and diamine oxidase levels. Rather than increase histamine during the test diet, eliminate it ...
Sparteine
... was catalyzed by the enzyme diamine oxidase. The aldehyde then spontaneously converts to the corresponding Schiff base, Δ1- ... The imine is then hydrolyzed to the corresponding aldehyde/amine. The primary amine is then oxidized to an aldehyde followed by ... Originally, it was thought that conversion of cadaverine to the corresponding aldehyde, 5-aminopentanal, ...
Phenethylamine
... a significant amount is metabolized in the small intestine by monoamine oxidase B (MAO-B) and then aldehyde dehydrogenase (ALDH ... monoamine oxidase A (MAO-A),[5][6] monoamine oxidase B (MAO-B),[3][4][5][14] the semicarbazide-sensitive amine oxidases (SSAOs ... "aldehyde dehydrogenase - Homo sapiens". BRENDA. Technische Universität Braunschweig. January 2015. Retrieved 13 April 2015.. ... is the primary urinary metabolite of phenethylamine and is produced via monoamine oxidase metabolism and subsequent aldehyde ...
Agmatine
... is by diamine oxidase-catalyzed oxidation into agmatine-aldehyde, which is in turn converted by aldehyde dehydrogenase into ... NADPH oxidase. Activation of the enzyme leading to H2O2 production. Agmatine sulfate injection can increase food intake with ... Demady DR, Jianmongkol S, Vuletich JL, Bender AT, Osawa Y (January 2001). "Agmatine enhances the NADPH oxidase activity of ...
Retinal oxidase
Huang DY, Furukawa A, Ichikawa Y (1999). "Molecular cloning of retinal oxidase/aldehyde oxidase cDNAs from rabbit and mouse ... Mandal SK, Datta Chaudhuri B (1987). "Enzymic oxidation of vitamin A aldehyde to vitamin A acid by rat livers of experimental ... This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with ... In enzymology, a retinal oxidase (EC 1.2.3.11) is an enzyme that catalyzes the chemical reaction retinal + O2 + H2O ⇌ {\ ...
2-alkenal reductase
... detoxication of the lipid peroxide-derived reactive aldehydes". Plant Cell Physiol. 43 (12): 1445-55. doi:10.1093/pcp/pcf187. ... Dihydrouracil oxidase. *Tetrahydroberberine oxidase. *Secologanin synthase. *Tryptophan alpha,beta-oxidase. *Pyrroloquinoline- ...
Mineral (nutrient)
The oxidases xanthine oxidase, aldehyde oxidase, and sulfite oxidase[31] Legumes, whole grains, nuts[25] molybdenum deficiency ... Required component of many redox enzymes, including cytochrome c oxidase Liver, seafood, oysters, nuts, seeds; some: whole ...
Vitamin C
l-gulonolactone oxidase, the last of the chain of four enzymes that synthesize vitamin C.[183][184] American biochemist Irwin ... The aldehyde group of this compound is reduced to a primary alcohol using the enzyme glucuronate reductase and the cofactor ... l-gulonolactone oxidase (GULO), that catalyses the last step in the biosynthesis, is highly mutated and non-functional.[117][ ... l-gulonolactone oxidase coding gene.[185] In 2008, researchers at the University of Montpellier discovered that in humans and ...
Vitamin C
The aldehyde group of this compound is reduced to a primary alcohol using the enzyme glucuronate reductase and the cofactor ... He later developed the theory that humans possess a mutated form of the L-gulonolactone oxidase coding gene.[185] ... Nishikimi M, Kawai T, Yagi K (October 1992). "Guinea pigs possess a highly mutated gene for L-gulono-gamma-lactone oxidase, the ... L-Gulonolactone then reacts with oxygen, catalyzed by the enzyme L-gulonolactone oxidase (which is nonfunctional in humans and ...
AKR1B1
cDNAs and deduced amino acid sequences of human aldehyde and aldose reductases". The Journal of Biological Chemistry. 264 (16 ... Xanthine oxidase. 1.1.4: disulfide as acceptor. *Vitamin K epoxide reductase. *Vitamin-K-epoxide reductase (warfarin- ... AR belongs to the aldehyde-keto reductase superfamily, with a widely expression in human organs including the kidney, lens, ... It also participates in glucose metabolism and osmoregulation and plays a protective role against toxic aldehydes derived from ...
Retinal
It was originally called retinene,[2] and renamed[3] after it was discovered to be vitamin A aldehyde.[4][5] Retinal is one of ... "KEGG ENZYME: 1.2.3.11 retinal oxidase". Retrieved 2009-03-10.. *^ Lamb, T D (1996). "Gain and kinetics of activation in the G- ... retinal + O2 + H2O → retinoic acid + H2O2 (catalyzed by retinal oxidase). catalyzed by retinal dehydrogenases[11] also known as ... BALL, S; GOODWIN, TW; MORTON, RA (1946). "Retinene1-vitamin A aldehyde". The Biochemical Journal. 40 (5-6): lix. PMID 20341217. ...
Glutamate decarboxylase
4.1.2: Aldehyde-lyases. *Fructose-bisphosphate aldolase *Aldolase A. *Aldolase B. *Aldolase C ...
اتیلن - ویکیپدیا، دانشنامهٔ آزاد
The final step requires oxygen and involves the action of the enzyme ACC-oxidase (ACO), formerly known as the ethylene forming ... the ACC releases ethylene with ACC oxidase. ...
Carbon monoxide
... is, along with aldehydes, part of the series of cycles of chemical reactions that form photochemical smog. It ... Carbon monoxide also binds to other molecules such as myoglobin and mitochondrial cytochrome oxidase. Exposures to carbon ... Large quantities of aldehydes are produced by the hydroformylation reaction of alkenes, carbon monoxide, and H2. ...
Coffee bean
Other proteins include enzymes, such as catalase and polyphenol oxidase, which are important for the maturation of green coffee ... Volatile compounds of green coffee beans include short-chain fatty acids, aldehydes, and nitrogen-containing aromatic molecules ... reaction products between the aldehyde group of sugar and the alpha-amino group of the amino acids). Further, diketopiperazines ...
Cyclophosphamide
Oral cyclophosphamide is rapidly absorbed and then converted by mixed-function oxidase enzymes (cytochrome P450 system) in the ... Most of the aldophosphamide is then oxidised by the enzyme aldehyde dehydrogenase (ALDH) to make carboxycyclophosphamide. A ... Kohn FR, Sladek NE (1985). "Aldehyde dehydrogenase activity as the basis for the relative insensitivity of murine pluripotent ...
Health effects of tobacco
Guillem K, Vouillac C, Azar MR, Parsons LH, Koob GF, Cador M, Stinus L (September 2005). "Monoamine oxidase inhibition ... Kataoka H, Sumida A, Makita M (1997). "Determination of aliphatic and aromatic aldehydes in cigarette smoke by gas ... beta-unsaturated aldehydes in cigarette smoke release inflammatory mediators from human macrophages". American Journal of ... "Transient behavioral sensitization to nicotine becomes long-lasting with monoamine oxidases inhibitors". Pharmacology ...
Potassium cyanide
... is a potent inhibitor of cellular respiration, acting on mitochondrial cytochrome c oxidase, hence blocking ... when reacted with a carbonyl compound such as an aldehyde or ketone in the presence of ammonium carbonate. ...
Collagen
Formation of the collagen fibril: lysyl oxidase, an extracellular copper-dependent enzyme, produces the final step in the ... This enzyme acts on lysines and hydroxylysines producing aldehyde groups, which will eventually undergo covalent bonding ... Multiple tropocollagen molecules form collagen fibrils, via covalent cross-linking (aldol reaction) by lysyl oxidase which ...
3-oxoacyl-(acyl-carrier-protein) reductase
Xanthine oxidase. 1.1.4: disulfide as acceptor. *Vitamin K epoxide reductase. *Vitamin-K-epoxide reductase (warfarin- ...
Synephrine
O. Suzuki, T. Matsumoto, M. Oya, and Y. Katsumata (1979). "Oxidation of synephrine by type A and type B monoamine oxidase." ... followed by a Reformatskii reaction of the protected aldehyde with ethyl bromoacetate/Zn to give the expected β-hydroxy ester. ... Studies of the metabolism of synephrine by monoamine oxidases derived from rat brain mitochondria showed that synephrine was a ...
Elastic fiber
Lysyl oxidase reacts with specific lysine residues and by oxidative deamination generates reactive aldehydes and allysine. ... These reactive aldehydes and allysines can react with lysine and other allysine residues to crosslink and form desmosine, ... Elastic fibers stain well with aldehyde fuchsin, orcein,[4] and Weigert's elastic stain in histological sections. ... and Marfan's syndrome have been associated with defects in copper metabolism and lysyl oxidase or defects in the microfibril ( ...
Hypochlorous acid
... releasing HCl and ammonia to form an aldehyde.[35] The aldehyde group can further react with another amino group to form a ... Later studies[38] revealed that Ubiquinol oxidase activity ceases first, and the still-active cytochromes reduce the remaining ... damage to Escherichia coli ubiquinol oxidase". Biochemistry. 28 (7): 3031-6. doi:10.1021/bi00433a044. PMID 2545243.. ... "Myeloperoxidase-mediated damage to the succinate oxidase system of Escherichia coli". J. Biol. Chem. 242: 15004-15010.. CS1 ...
Lignin
gymnosperm).[43] Ratios of carboxylic acid (Ad) to aldehyde (Al) forms of the lignols (Ad/Al) reveal diagenetic information, ... The reaction has two alternative routes catalysed by two different oxidative enzymes, peroxidases or oxidases. ...
Methanol toxicity
... via aldehyde dehydrogenase (ALDH). The conversion to formate via ALDH proceeds completely, with no detectable formaldehyde ... remaining.[10] Formate is toxic because it inhibits mitochondrial cytochrome c oxidase, causing hypoxia at the cellular level, ...
Phosphorylation
Babior BM (March 1999). "NADPH oxidase: an update". Blood. 93 (5): 1464-76. PMID 10029572.. ... Phosphorylation of the cytosolic components of NADPH oxidase, a large membrane-bound, multi-protein enzyme present in ...
Heme
Thus cytochrome oxidase, which has two A hemes (heme a and heme a3) in its structure, contains two moles of heme A per mole ... In two sequential reactions a 17-hydroxyethylfarnesyl moiety is added at the 2-position and an aldehyde is added at the 8- ... Cytochrome a refers to the heme A in specific combination with membrane protein forming a portion of cytochrome c oxidase.[13] ... PPOX: protoporphyrinogen oxidase (deficiency causes variegate porphyria)[42]. *UROD: uroporphyrinogen decarboxylase (deficiency ...
Naturally occurring phenols
Phenolic acids, Phenolic aldehydes Gallic, salicylic acids 8 C6-C2 1 Acetophenones, Tyrosine derivatives, Phenylacetic acids 3- ... There is a risk that polyphenol oxidase (PPO) degrades the phenolic content of the sample therefore there is a need to use PPO ... Aryl-alcohol dehydrogenase (NADP+) uses an aromatic alcohol and NADP+ to produce an aromatic aldehyde, NADPH and H+. ... Aryl-alcohol dehydrogenase uses an aromatic alcohol and NAD+ to produce an aromatic aldehyde, NADH and H+. ...
Cofactor (biochemistry)
Chan MK, Mukund S, Kletzin A, Adams MW, Rees DC (March 1995). "Structure of a hyperthermophilic tungstopterin enzyme, aldehyde ... Cytochrome oxidase Ferrous or Ferric. Catalase. Cytochrome (via Heme). Nitrogenase. Hydrogenase Magnesium. Glucose 6- ... tungsten in the aldehyde ferredoxin oxidoreductase of the thermophilic archaean Pyrococcus furiosus,[18] and even cadmium in ...
Hyoscyamine
A putrescine oxidase (EC 1.4.3.10) that specifically recognizes methylated putrescine catalyzes the deamination of this ... A cytochrome P450 classified as Cyp80F1[4] oxidizes and rearranges littorine to hyoscyamine aldehyde. ...
Aldehyde oxidase - Wikipedia
Aldehyde oxidase is very concentrated in the liver, where it oxidizes multiple aldehydes and nitrogenous heterocyclic compounds ... Aldehyde oxidase is a member of the molybdenum flavoprotein family and has a very complex evolutionary profile-as the genes of ... Aldehyde oxidase is thought to have a significant impact on pharmacokinetics. AO is capable of oxidizing many drugs in the ... Aldehyde oxidase (AO) is a metabolizing enzyme, located in the cytosolic compartment of tissues in many organisms. AO catalyzes ...
The mammalian aldehyde oxidase gene family. - PubMed - NCBI
Aldehyde oxidase genes in vertebrates. The figure contains a schematic representation of the aldehyde oxidase genes in selected ... Phylogeny of eukaryotic aldehyde oxidases. A rooted dendrogram was obtained by the Phylip method after CLUSTAL-W computer-aided ... Aldehyde oxidases (EC 1.2.3.1) are a small group of structurally conserved cytosolic proteins represented in both the animal ... The mammalian aldehyde oxidase gene family.. Garattini E1, Fratelli M, Terao M. ...
Aryl-aldehyde oxidase - Wikipedia
In enzymology, an aryl-aldehyde oxidase (EC 1.2.3.9) is an enzyme that catalyzes the chemical reaction an aromatic aldehyde + ... Crawford DL, Sutherland JB, Pometto AL, Miller JM (June 1982). "Production of an aromatic aldehyde oxidase by Streptomyces ... This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with ... The systematic name of this enzyme class is aryl-aldehyde:oxygen oxidoreductase. ...
Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead (IPR000674) | InterPro | EMBL-EBI
Aldehyde oxidase (EC:1.2.3.1) catalyses the conversion of an aldehyde in the presence of oxygen and water to an acid and ... Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead (IPR000674). Short name: Ald_Oxase/Xan_DH_a/b ... The aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain is an evolutionary conserved protein domain [PMID: ... Crystal structure of the xanthine oxidase-related aldehyde oxido-reductase from D. gigas.. Science 270 1170-6 1995 ...
Aldehyde oxidase as a cell marker for internal organs in Drosophila melanogaster. - PubMed - NCBI
Strategies for a comprehensive understanding of metabolism by aldehyde oxidase
A pheromone-degrading aldehyde oxidase in the antennae of the moth Manduca sexta | Journal of Neuroscience
Antennae of the tobacco hornworm moths Manduca sexta contain an aldehyde oxidase (AOX) that oxidizes aldehydes to carboxylic ... A pheromone-degrading aldehyde oxidase in the antennae of the moth Manduca sexta. R Rybczynski, J Reagan and MR Lerner ... A pheromone-degrading aldehyde oxidase in the antennae of the moth Manduca sexta ... A pheromone-degrading aldehyde oxidase in the antennae of the moth Manduca sexta ...
Aldehyde oxidase-catalysed oxidation of methotrexate in the liver of guinea-pig, rabbit and man
The goals of this study were to determine the role of aldehyde oxidase in the metabolism of methotrexate to 7-hydroxy … ... Rabbit liver aldehyde oxidase was used for purposes of comparison. In-vitro aldehyde oxidase from the liver of man catalyses ... potent inhibitors of aldehyde oxidase. Allopurinol (100 microM) had a negligible inhibitory effect on liver aldehyde oxidase ... Aldehyde oxidase-catalysed oxidation of methotrexate in the liver of guinea-pig, rabbit and man J Pharm Pharmacol. 1999 Apr;51( ...
AOX2 (aldehyde oxidase 2) - KOMP (Knockout Mouse Project)
Mouse Anti-Human Xanthine Oxidase / Aldehyde Oxidase Ab-2 Mouse Monoclonal Antibody, Biotin Conjugated, Clone 145.4 from Lab...
Aldehyde Oxidase Ab-2 Mouse Monoclonal Antibody, Biotin Conjugated, Clone 145.4 from Lab Vision,In normal tissues this enzyme ... Mouse Anti-Human Xanthine Oxidase / Aldehyde Oxidase Ab-2 Mouse Monoclonal Antibody, Biotin Conjugated, Clone 145.4 from Lab ... Mouse Anti-Human Xanthine Oxidase / Aldehyde Oxidase Ab-2 Mouse Monoclonal Antibody, Biotin Conjugated, Clone 145.4 from Lab ... Mouse Anti-Human Xanthine Oxidase / Aldehyde Oxidase Ab-2 Mouse Monoclonal Antibody, Biotin Conjugated, Clone 145.4. ...
POTENT INHIBITION OF HUMAN LIVER ALDEHYDE OXIDASE BY RALOXIFENE | Drug Metabolism & Disposition
... determine potency versus various classes of aldehyde oxidase-catalyzed reactions, determine specificity for aldehyde oxidase ... Aldehyde oxidase is an enzyme involved in the metabolism of drugs and other xenobiotics that possess aldehyde and ... Aldehyde oxidase converts aldehydes to carboxylic acids and azaheterocyclic compounds to lactams using molecular oxygen as an ... However, raloxifene had only small effects on xanthine oxidase, an enzyme related to aldehyde oxidase. In addition, several ...
Oxidative Metabolic Pathway of Lenvatinib Mediated by Aldehyde Oxidase | Drug Metabolism & Disposition
Aldehyde oxidase (AO) is a molybdenum enzyme that catalyzes the oxidation of aldehydes and azaheterocyclic derivatives to ... aldehyde oxidase. DDI. drug-drug interaction. FMO. flavin-containing monooxygenase. GSH. glutathione. HPLC. high-performance ... 2010) Aldehyde oxidase: an enzyme of emerging importance in drug discovery. J Med Chem 53:8441-8460. ... 2008) Aldehyde oxidase activity and inhibition in hepatocytes and cytosolic fractions from mouse, rat, monkey and human. Drug ...
Mechanism of palladium/amine cocatalyzed carbocyclization of aldehydes with alkynes and its merging with "Pd oxidase catalysis"
Genetic Regulation of Alcohol Dehydrogenase, Aldehyde Dehydrogenase and Aldehyde Oxidase Isozymes in the Mouse | Springer for...
... the mitochondrial isozyme of aldehyde dehydrogenase (AHD-A2) and aldehyde oxidase isozymes (AOX-l; AOX-2)... ... Aldehyde Dehydrogenase and Aldehyde Oxidase Isozymes in the Mouse. In: Thurman R.G. (eds) Alcohol and Aldehyde Metabolizing ... Inbred Strain Aldehyde Dehydrogenase Aldehyde Oxidase Codominant Allele Female Reproductive Tissue These keywords were added by ... Genetic Regulation of Alcohol Dehydrogenase, Aldehyde Dehydrogenase and Aldehyde Oxidase Isozymes in the Mouse. ...
Immobilisation and characterisation of biocatalytic co-factor recycling enzymes, glucose dehydrogenase and NADH oxidase, on...
... and NADH oxidase (NOD) on aldehyde functional ReSynTM polymer microspheres with varying functional group densities. The ... Immobilisation and characterisation of biocatalytic co-factor recycling enzymes, glucose dehydrogenase and NADH oxidase, on ... aldehyde functional ReSynTM polymer microspheres. Twala, BV; Sewell, BT; Jordaan, J URI: http://www.sciencedirect.com/science/ ...
Aldehyde oxidase elisa and antibody
Recombinant Protein and Aldehyde oxidase Antibody at MyBioSource. Custom ELISA Kit, Recombinant Protein and Antibody are ... Aldehyde oxidase GLOX. Aldehyde oxidase GLOX ELISA Kit. Aldehyde oxidase GLOX Recombinant. Aldehyde oxidase GLOX Antibody ... Aldehyde oxidase GLOX1. Aldehyde oxidase GLOX1 ELISA Kit. Aldehyde oxidase GLOX1 Recombinant. Aldehyde oxidase GLOX1 Antibody ... Aldehyde oxidase 1. Aldehyde oxidase 1 ELISA Kit. Aldehyde oxidase 1 Recombinant. Aldehyde oxidase 1 Antibody ...
ENZYME - 1.2.3.1 Aldehyde oxidase
4, Aldehyde, mouse, oxidase: Causes & Reasons - Symptoma®
... oxidase Symptom Checker: Possible causes include Thiouracil, Raloxifene, Aldehyde. Check the full list of possible causes and ... 3,663 Possible Causes for 4,, Aldehyde, mouse, oxidase Did you mean: 4, Aldehyde, morus, oxidase ... The mediation of oxidases glucose oxidase (GOx), lactate oxidase (LOx) and cholesterol oxidase (ChOx) by a new electron ... primarily to differences of aldehyde oxidase activity.[ncbi.nlm.nih.gov] […] investigated the hypothesis if raloxifene, a ...
Aromatic alcohol oxidase, aldehyde oxidase and mannitol oxidase in terrestrial gastropods - Wolverhampton Intellectual...
Digestion and absorption of bovine milk xanthine oxidase and its role as an aldehyde oxidase | Meta
Digestion and absorption of bovine milk xanthine oxidase and its role as an aldehyde oxidase. The Journal of Nutrition ... Xanthine oxidase activity and immunologically detectable protein in the C57B1/6 mouse. (opens in new tab) ... The role of xanthine oxidase in platelet activating factor induced intestinal injury in the rat. (opens in new tab) ... The effects of acidic and intestinal proteolytic environments on bovine milk xanthine oxidase (XO) activity were determined in ...
Mo MOLYBDENUM TUNGSTEN Nitrogenase Xanthine oxidase Aldehyde Oxidoreductase MOP
Скачать презентацию Mo MOLYBDENUM TUNGSTEN Nitrogenase Xanthine oxidase Aldehyde Oxidoreductase MOP 19-Mo Ni Mn Со Биохимия ... Mo MOLYBDENUM/TUNGSTEN Nitrogenase Xanthine oxidase Aldehyde Oxidoreductase (MOP) Dimethylsulfoxide Reductase Trimethylamine N- ... Reductase Formaldehyde Ferredoxin Oxidoreductase Aldehyde Ferredoxin Oxidoreductase Formate Dehydrogenase H Sulfite Oxidase CO ...
Cattle Aldehyde Oxidase 1 (AOX1) ELISA Kit, Cat#EKU02229 - Biomatik
Cattle Aldehyde Oxidase 1 (AOX1) ELISA Kit, Cat#EKU02229. Write a Review Write a Review. × ... The concentration of Aldehyde Oxidase 1 (AOX1) in the samples is then determined by comparing the O.D. of the samples to the ... Cattle Aldehyde Oxidase 1 (AOX1) ELISA Kit, Cat#EKU02229. Rating Required Select Rating. 1 star (worst). 2 stars. 3 stars ( ... The microtiter plate provided in this kit has been pre-coated with an antibody specific to Aldehyde Oxidase 1 (AOX1). Standards ...
Cloning of the cDNAs coding for two novel molybdo-flavoproteins showing high similarity with aldehyde oxidase and xanthine...
Acetaldehyde dehydrogenase - Wikipedia
Aldehyde oxidase. 1.2.4: disulfide. *Oxoglutarate dehydrogenase complex. *Pyruvate dehydrogenase. *Branched-chain alpha-keto ... Wang X, Weiner H (Jan 1995). "Involvement of glutamate 268 in the active site of human liver mitochondrial (class 2) aldehyde ... Crabb D, Xiao Q (Jun 1998). "Studies on the enzymology of aldehyde dehydrogenase-2 in genetically modified HeLa cells". ... Hempel J, von Bahr-Lindström H, Jörnvall H (May 1984). "Aldehyde dehydrogenase from human liver. Primary structure of the ...
BCKDHA - Wikipedia
New tasks for old enzymes: xanthine oxidase and aldehyde oxidoreductase
- Universidade NOVA de Lisboa
4uhw - Proteopedia, life in 3D
Aldehyde oxidase (AOX) is a xanthine oxidase (XO)-related enzyme with emerging importance due to its role in the metabolism of ... Fu C, Di L, Han X, Soderstrom C, Snyder M, Troutman MD, Obach RS, Zhang H. Aldehyde oxidase 1 (AOX1) in human liver cytosols: ... Characterization of aldehyde oxidase enzyme activity in cryopreserved human hepatocytes. Drug Metab Dispos. 2012 Feb;40(2):267- ... Rashidi MR, Smith JA, Clarke SE, Beedham C. In vitro oxidation of famciclovir and 6-deoxypenciclovir by aldehyde oxidase from ...
Aldehyde dehydrogenase | enzyme | Britannica
... aldehyde dehydrogenase, and converted to acetate, most of which enters the bloodstream and is ultimately oxidized to carbon ... Other articles where Aldehyde dehydrogenase is discussed: alcohol consumption: Processing in the liver: …acted upon by another ... Aldehyde dehydrogenase. enzyme. Alternative Title: aldehyde oxidase. Learn about this topic in these articles:. alcohol ... acted upon by another enzyme, aldehyde dehydrogenase, and converted to acetate, most of which enters the bloodstream and is ...
Aldehyde Oxidases as Enzymes in Phase I Drug Metabolism<...
Aldehyde Oxidases as Enzymes in Phase I Drug Metabolism. Together they form a unique fingerprint. * Aldehyde Oxidase Medicine ... Aldehyde oxidases are a group of enzymes with important functions in the context of drug and xenobiotic metabolism. Aldehyde ... Aldehyde oxidases are a group of enzymes with important functions in the context of drug and xenobiotic metabolism. Aldehyde ... Aldehyde oxidases are a group of enzymes with important functions in the context of drug and xenobiotic metabolism. Aldehyde ...
EnzymeDehydrogenaseOxidoreductasesOxidoreductaseEnzymesSulfite oxidaseAox1Mammalian aldehyde oxidase gene familyCarboxylicSubstrate specificityLiverMolybdenumAbstractInhibitionInhibitors of aldehyde oxidaseCytochromeHepatic aldehyde oxidaseRetinal oxidaseGenesDegradationGeneSubstratesConvertsReductaseQuinoline oxidaseAlcoholProteinCharacterizationVariety of aldehydesNADHAmineInhibitorAbscisic aldehydeHydrogen peroxideActivityElectronMetabolicNADPHDehydrogenasesHydroxylaseCatalysisTissues
Enzyme24
- Aldehyde oxidase (AO) is a metabolizing enzyme, located in the cytosolic compartment of tissues in many organisms. (wikipedia.org)
- In enzymology, an aryl-aldehyde oxidase (EC 1.2.3.9) is an enzyme that catalyzes the chemical reaction an aromatic aldehyde + O2 + H2O ⇌ {\displaystyle \rightleftharpoons } an aromatic carboxylic acid + H2O2 The 3 substrates of this enzyme are aromatic aldehyde, O2, and H2O, whereas its two products are aromatic carboxylic acid and H2O2. (wikipedia.org)
- This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with oxygen as acceptor. (wikipedia.org)
- The systematic name of this enzyme class is aryl-aldehyde:oxygen oxidoreductase. (wikipedia.org)
- This activity is often found in a bifunctional enzyme with xanthine oxidase ( EC:1.1.3.22 ) activity too. (ebi.ac.uk)
- The enzyme can be converted from the dehydrogenase form to the oxidase form irreversibly by proteolysis or reversibly through oxidation of sulphydryl groups. (ebi.ac.uk)
- The enzyme, which is distinguishable from aldehyde-oxidizing activities in other tissues, is secreted into the receptor lymph that bathes the primary olfactory dendrites. (jneurosci.org)
- However, raloxifene had only small effects on xanthine oxidase, an enzyme related to aldehyde oxidase. (aspetjournals.org)
- Aldehyde oxidase is an enzyme involved in the metabolism of drugs and other xenobiotics that possess aldehyde and azaheterocyclic substituents, among others ( Beedham, 2002 ). (aspetjournals.org)
- However, compared with the cytochrome P450 family, the number of drugs for which aldehyde oxidase is the major enzyme responsible for clearance is few. (aspetjournals.org)
- Although both lenvatinib and M2 were substrates for aldehyde oxidase, an enzyme kinetic study indicated that M2 was a much more favorable substrate than lenvatinib. (aspetjournals.org)
- The enzyme from liver exhibits a broad substrate specificity, and is involved in the metabolism of xenobiotics, including the oxidation of N-heterocycles and aldehydes and the reduction of N-oxides, nitrosamines, hydroxamic acids, azo dyes, nitropolycyclic aromatic hydrocarbons, and sulfoxides. (expasy.org)
- The effects of acidic and intestinal proteolytic environments on bovine milk xanthine oxidase (XO) activity were determined in order to evaluate the extent to which this enzyme was absorbed in biologically active form. (meta.org)
- After TMB substrate solution is added, only those wells that contain Aldehyde Oxidase 1 (AOX1), biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. (biomatik.com)
- acted upon by another enzyme, aldehyde dehydrogenase, and converted to acetate, most of which enters the bloodstream and is ultimately oxidized to carbon dioxide and water. (britannica.com)
- Aldehyde oxidase (AOX) is a xanthine oxidase (XO)-related enzyme with emerging importance due to its role in the metabolism of drugs and xenobiotics. (proteopedia.org)
- Characterization of aldehyde oxidase enzyme activity in cryopreserved human hepatocytes. (proteopedia.org)
- Substrate specificity of human liver aldehyde oxidase toward substituted quinazolines and phthalazines: a comparison with hepatic enzyme from guinea pig, rabbit, and baboon. (proteopedia.org)
- The alcohol oxidase enzyme activity has broadly similar properties (Km values, substrate specificity, pH, and heat stability) to yeast enzymes. (edu.au)
- This enzyme is necessary for the normal function of xanthine dehydrogenase, described above, and another enzyme called aldehyde oxidase. (medlineplus.gov)
- The enzyme is also responsible for the oxidation of retinal, an activity that was initially attributed to a distinct enzyme ( EC 1.2.3.11 , retinal oxidase) [5,7]. (qmul.ac.uk)
- 2. Knox, W.E. The quinine-oxidizing enzyme and liver aldehyde oxidase. (qmul.ac.uk)
- Type II xanthinuria is characterized by a deficiency of xanthine dehydrogenase and a related enzyme, aldehyde oxidase. (medscape.com)
- In humans, molybdenum is a cofactor for three enzyme classes-sulfiteoxidase, aldehyde dehydrogenase, and xanthine oxidase (Kisker et al. (cdc.gov)
Dehydrogenase13
- Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain Gordon AH, Green DE, Subrahmanyan V (May 1940). (wikipedia.org)
- The aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain is an evolutionary conserved protein domain [ PMID: 7502041 , PMID: 10430865 ]. (ebi.ac.uk)
- Ahd-1 (encoding AHD-A 2 ) was found on chromosome 4 near Gpd-1 (encoding the liver isozyme of glucose-6-phosphate dehydrogenase), whereas the aldehyde oxidase loci (Aox-1, Aox-2) were closely linked on chromosome 1 near Id-1 (encoding isocitrate dehydrogenase). (springer.com)
- Holmes, R. S., 1977, The genetics of a-hydroxyacid oxidase and alcohol dehydrogenase in the mouse: evidence for multiple gene loci and linkage between Hao-2 and Adh-3, Genetics 87:709. (springer.com)
- Holmes, R.S., 1978b, Genetics and ontogeny of aldehyde dehydrogenase isozymes in the mouse: localization of Ahd-1 encoding the mitochondrial isozymes on chromosome 4, Biochem. (springer.com)
- Here we describe the immobilisation of two biocatalytically relevant co-factor recycling enzymes, glucose dehydrogenase (GDH) and NADH oxidase (NOD) on aldehyde functional ReSynTM polymer microspheres with varying functional group densities. (csir.co.za)
- These included genes predicted to encode acetaldehyde dehydrogenase (Aldh1) and alcohol oxidase (Aox1). (edu.au)
- Tyrosine hydroxylase, monoamine oxidase and aldehyde dehydrogenase all form oxygen radicals as part of their mechanisms of action. (scirp.org)
- Monoamine oxidase converts dopamine into 3,4-dihydroxyphenylacetaldehyde and forms oxygen radi-cals.Aldehyde dehydrogenase oxidizes the aldehyde and forms oxygen radicals and 3,4-dihydroxyphenylacetic acid. (scirp.org)
- Mutations in the MOCOS gene prevent xanthine dehydrogenase and aldehyde oxidase from being turned on (activated). (medlineplus.gov)
- There are only a few Moco enzymes known in eukaryotes: xanthine dehydrogenase (XDH) in purine catabolism, aldehyde oxidase (AldOx), sulfite oxidase, the mitochondrial amidoxime-reducing components mARC1 and mARC2, and nitrate reductase [ 3 , 4 ]. (biochemj.org)
- The distinction between the 2 types is based on the ability or inability to oxidize allopurinol, a substrate for xanthine dehydrogenase and aldehyde oxidase. (medscape.com)
- This condition is inherited recessively and is caused by a congenital defect of a molybdenum-containing cofactor essential for the function of 3 distinct enzymes (ie, xanthine dehydrogenase, aldehyde oxidase, sulfite oxidase). (medscape.com)
Oxidoreductases2
- Aldehyde oxidases (AOXs) and xanthine oxidoreductases (XORs) are structurally and evolutionarily linked molybdoflavoproteins. (unl.pt)
- The sequence alignment of different aldehyde oxidase AOX isoforms identified variations in the active site of mAOX3 in comparison to other AOX proteins and xanthine oxidoreductases XOR. (duhnnae.com)
Oxidoreductase5
- In vertebrates, aldehyde oxidases constitute the small sub-family of molybdo-flavoenzymes, along with the evolutionarily and structurally related protein, xanthine oxidoreductase. (nih.gov)
- Aldehyde oxidoreductase from Desulfovibrio gigas (DgAOR) is a homodimeric molybdenum-containing protein that catalyzes the hydroxylation of aldehydes to carboxylic acids and contains a Mo-pyranopterin active site and two FeS centers called FeS 1 and FeS 2. (conicet.gov.ar)
- Biochemical/spectroscopic characterization and preliminary X-ray analysis of a new aldehyde oxidoreductase isolated from Desulfovibrio desulfuricans ATCC 27774. (genome.jp)
- Aldehyde oxidoreductase activity in Desulfovibrio alaskensis NCIMB 13491 EPR assignment of the proximal [2Fe-2S] cluster to the Mo site. (genome.jp)
- Molybdenum cofactor is a cofactor required for the activity of enzymes such as sulfite oxidase, xanthine oxidoreductase, and aldehyde oxidase. (hmdb.ca)
Enzymes8
- It is a member of a family of enzymes referred to as molybdenum cofactor-containing enzymes that also includes xanthine oxidase, due to the presence of the unique molybdopterin prosthetic group. (aspetjournals.org)
- Thus, as a target of drug-drug interactions, the importance of aldehyde oxidase is substantially less than that of cytochrome P450 enzymes. (aspetjournals.org)
- These enzymes are members of the larger class of aldehyde dehydrogenases . (wikipedia.org)
- Aldehyde oxidases are a group of enzymes with important functions in the context of drug and xenobiotic metabolism. (unl.pt)
- Belongs to the xanthine oxidase family of enzymes. (genome.jp)
- Here we show that odorants with functional groups such as aldehydes and esters are targets of metabolic enzymes secreted in the mouse mucus, resulting in their conversion to the corresponding acids and alcohols. (jneurosci.org)
- Enzymes that contain the molybdopterin cofactor include xanthine oxidase, DMSO reductase, sulfite oxidase, and nitrate reductase. (wikipedia.org)
- Tungsten-using enzymes typically reduce free carboxylic acids to aldehydes. (wikipedia.org)
Sulfite oxidase1
- Xanthinuria is only a marker in this setting because (1) the clinical presentation is overshadowed by neurologic manifestations and (2) death in the first year of life is caused by the deficiency of sulfite oxidase, which is the final step in cysteine metabolism. (medscape.com)
Aox19
- In humans, a single aldehyde oxidase gene ( AOX1 ) and two pseudogenes clustering on a short stretch of chromosome 2q are known. (nih.gov)
- AOX1: Aldehyde oxidase produces hydrogen peroxide and, under certain conditions, can catalyze the formation of superoxide. (mybiosource.com)
- Intra-assay Precision (Precision within an assay): 3 samples with low, middle and high level Aldehyde Oxidase 1 (AOX1) were tested 20 times on one plate, respectively. (biomatik.com)
- Inter-assay Precision (Precision between assays): 3 samples with low, middle and high level Aldehyde Oxidase 1 (AOX1) were tested on 3 different plates, 8 replicates in each plate. (biomatik.com)
- This assay has high sensitivity and excellent specificity for detection of Aldehyde Oxidase 1 (AOX1). (biomatik.com)
- The microtiter plate provided in this kit has been pre-coated with an antibody specific to Aldehyde Oxidase 1 (AOX1). (biomatik.com)
- Standards or samples are then added to the appropriate microtiter plate wells with a biotin-conjugated antibody specific to Aldehyde Oxidase 1 (AOX1). (biomatik.com)
- The concentration of Aldehyde Oxidase 1 (AOX1) in the samples is then determined by comparing the O.D. of the samples to the standard curve. (biomatik.com)
- Fu C, Di L, Han X, Soderstrom C, Snyder M, Troutman MD, Obach RS, Zhang H. Aldehyde oxidase 1 (AOX1) in human liver cytosols: quantitative characterization of AOX1 expression level and activity relationship. (proteopedia.org)
Mammalian aldehyde oxidase gene family1
- The mammalian aldehyde oxidase gene family. (nih.gov)
Carboxylic4
- AO catalyzes the oxidation of aldehydes into carboxylic acid, and in addition, catalyzes the hydroxylation of some heterocycles. (wikipedia.org)
- Antennae of the tobacco hornworm moths Manduca sexta contain an aldehyde oxidase (AOX) that oxidizes aldehydes to carboxylic acids. (jneurosci.org)
- Aldehyde oxidase converts aldehydes to carboxylic acids and azaheterocyclic compounds to lactams using molecular oxygen as an electron acceptor. (aspetjournals.org)
- Catalyzes the oxidation of aldehydes to the corresponding carboxylic acids by coupling the reaction to the reduction of dioxygen to hydrogen peroxide. (mybiosource.com)
Substrate specificity2
- Aldehyde oxidases have broad substrate specificity and catalyse the hydroxylation of N-heterocycles and the oxidation of aldehydes to the corresponding acid. (nih.gov)
- In order to elucidate factors that determine substrate specificity and activity of mammalian molybdo-flavoproteins we performed site directed mutagenesis of mouse aldehyde oxidase 3 mAOX3. (duhnnae.com)
Liver15
- Aldehyde oxidase is very concentrated in the liver, where it oxidizes multiple aldehydes and nitrogenous heterocyclic compounds, such as anti-cancer and immunosuppressive drugs. (wikipedia.org)
- The goals of this study were to determine the role of aldehyde oxidase in the metabolism of methotrexate to 7-hydroxymethotrexate in the liver and to study the effects of inhibitors and other substrates on the metabolism of methotrexate. (nih.gov)
- Methotrexate, (+/-)-methotrexate and (-)-methotrexate were incubated with partially purified aldehyde oxidase from the liver of rabbit, guinea-pig and man and the products analysed by HPLC. (nih.gov)
- Rabbit liver aldehyde oxidase was used for purposes of comparison. (nih.gov)
- In-vitro aldehyde oxidase from the liver of man catalyses the oxidation of methotrexate to 7-hydroxymethotrexate, but the turnover is low. (nih.gov)
- However, formation of 7-hydroxy-methotrexate from all forms of methotrexate by the liver in guinea-pig and man was significantly inhibited in the presence of 100 microM menadione and chlorpromazine, potent inhibitors of aldehyde oxidase. (nih.gov)
- Allopurinol (100 microM) had a negligible inhibitory effect on liver aldehyde oxidase from guinea-pig and man. (nih.gov)
- By employing potent selective inhibitors of aldehyde oxidase, menadione and chlorpromazine, we have demonstrated for the first time that liver aldehyde oxidase from man is minimally involved in methotrexate oxidation. (nih.gov)
- The selective estrogen receptor modulator, raloxifene, has been demonstrated as a potent uncompetitive inhibitor of human liver aldehyde oxidase-catalyzed oxidation of phthalazine, vanillin, and nicotine-Δ1′(5′)-iminium ion, with K i values of 0.87 to 1.4 nM. (aspetjournals.org)
- In a previous report, over 200 frequently prescribed drugs and other compounds were tested as inhibitors of human liver cytosolic aldehyde oxidase activity (O. Obach, et al. (aspetjournals.org)
- The most potent inhibitor observed was the selective estrogen receptor modulator (SERM 1 ), raloxifene, which demonstrated an extremely low IC 50 value of 2.9 nM for phthalazine oxidase in human liver cytosol. (aspetjournals.org)
- Evidence for substrate-dependent inhibition profiles for human liver aldehyde oxidase. (proteopedia.org)
- Rashidi MR, Smith JA, Clarke SE, Beedham C. In vitro oxidation of famciclovir and 6-deoxypenciclovir by aldehyde oxidase from human, guinea pig, rabbit, and rat liver. (proteopedia.org)
- We hypothesised that fatty liver improvement by MNA would be further enhanced by suppressing its rapid metabolism by aldehyde oxidase in the liver. (elsevier.com)
- Banks RB, Cooke RT Jr (1986) Chromate reduction by rabbit liver aldehyde oxidase. (springer.com)
Molybdenum1
- Aldehyde oxidase is a member of the molybdenum flavoprotein family and has a very complex evolutionary profile-as the genes of AO varies according to animal species. (wikipedia.org)
Abstract1
- abstract = "This chapter discusses the significance of aldehyde oxidases for the design and development of new drugs, and discusses associated problems. (unl.pt)
Inhibition2
- The objectives of the present study are to further characterize the inhibition of human aldehyde oxidase by raloxifene. (aspetjournals.org)
- Marketed drugs cleared by aldehyde oxidase (AO) are few, with no known clinically relevant pharmacokinetic drug interactions associated with AO inhibition, whereas cytochrome P450 (P450) inhibition or induction mediates a number of clinical drug interactions. (unthsc.edu)
Inhibitors of aldehyde oxidase1
- The formation of M3′ from lenvatinib occurred independently of NADPH and was effectively inhibited by typical inhibitors of aldehyde oxidase, indicating the involvement of aldehyde oxidase, but not P450s, in this pathway. (aspetjournals.org)
Cytochrome4
- It can also catalyze the oxidation of both cytochrome P450 (CYP450) and monoamine oxidase (MAO) intermediate products. (wikipedia.org)
- As efforts in drug design strive to reduce or remove cytochrome P450 metabolic lability, new drugs will be cleared by other mechanisms, such as aldehyde oxidase-mediated metabolism. (aspetjournals.org)
- COX-2 mRNA expression decreases significantly, while human mitochondrial cytochrome C oxidase subunit IImRNA expression increases significantly in HIEC treated with CO. [ncbi.nlm.nih.gov] The hemolytic potential in mouse erythrocytes was also tested for 1-3. (symptoma.com)
- Although heme C is found in many cytochrome c and c1 proteins, heme A is the cofactor of only one known protein, cytochrome c oxidase (CcO). (symptoma.com)
Hepatic aldehyde oxidase1
- 6. Yoshihara, S. and Tatsumi, K. Purification and characterization of hepatic aldehyde oxidase in male and female mice. (qmul.ac.uk)
Retinal oxidase3
- Also known as Aldehyde oxidase 4 (Aldehyde oxidase homolog 2) (Azaheterocycle hydroxylase 4) (Retinal oxidase). (mybiosource.com)
- Retinal oxidase. (expasy.org)
- Molecular cloning of retinal oxidase/aldehyde oxidase cDNAs from rabbit and mouse livers and functional expression of recombinant mouse retinal oxidase cDNA in Escherichia coli. (genome.jp)
Genes3
- In other mammals, a variable number of structurally conserved aldehyde oxidase genes has been described. (nih.gov)
- The figure contains a schematic representation of the aldehyde oxidase genes in selected vertebrates for which complete or almost complete genomic sequence data are available. (nih.gov)
- Mutant analyses and 13 C NMR studies also confirmed that the soxBDAG genes, predicted to encode a sarcosine oxidase, are required for sarcosine catabolism. (asm.org)
Degradation2
- Degradation primarily by xanthine oxidase. (drugbank.ca)
- Copper oxidases for cellulose degradation. (york.ac.uk)
Gene2
- Aldehyde oxidase is a candidate gene for amyotrophic lateral sclerosis. (mybiosource.com)
- IMSEAR at SEARO: Cloning and expression analysis of an aldehyde oxidase gene in Arachis hygogaea L. (who.int)
Substrates5
- Aldehyde oxidase (AO) is a drug-metabolizing molybdo-flavoenzyme with profound species differences in expression and activity toward various substrates. (nih.gov)
- No inhibitory activities of lenvatinib, M2′, or M3′ and no significant inhibitory activities of M2 or M3 on aldehyde oxidase were observed, suggesting a low possibility of drug-drug interactions in combination therapy with substrates of aldehyde oxidase. (aspetjournals.org)
- Both proteins prefer indole-3-aldehyde and naphthaldehyde as substrates, although high activities against abscisic aldehyde and citral were also observed. (usda.gov)
- The Km values of PsAO3 for naphthaldehyde and abscisic aldehyde (4.6 and 5.1 μM, respectively) were the lowest among the substrates tested. (usda.gov)
- Other substrates that are oxidized by aldehyde oxidase, such as pyrazinamide and N -methylnicotinamide, can be used to distinguish between types I and II. (medscape.com)
Converts1
- In Corynebacterium ( 8 , 37 ) and Arthrobacter ( 24 ), a heterotetrameric sarcosine oxidase converts sarcosine into glycine. (asm.org)
Reductase1
- Crystal structure of the xanthine oxidase-related aldehyde oxido-reductase from D. gigas. (ebi.ac.uk)
Quinoline oxidase1
- Quinoline oxidase. (expasy.org)
Alcohol2
- Notably, the latent Pd(0)/Pd(II) catalytic redox cycle of this metal/organo cooperative catalytic reaction can be merged with catalytic direct aerobic alcohol oxidation (Pd oxidase catalysis). (diva-portal.org)
- These results identify alcohol oxidase as a novel pathogenicity factor and are discussed in relation to peroxisomal metabolism of fungal pathogens during growth in planta. (edu.au)
Protein1
- Recombinant ABA2 protein produced in Escherichia coli exhibits a K m value for xanthoxin of 19 μM and catalyzes in a NAD-dependent manner the conversion of xanthoxin to abscisic aldehyde, as determined by HPLC-mass spectrometry. (plantcell.org)
Characterization2
- Purification and characterization of an aldehyde oxidase from Pseudomonas sp. (genome.jp)
- Cloning and molecular characterization of plant aldehyde oxidase. (semanticscholar.org)
Variety of aldehydes1
- The antennal AOX is a dimer with Mr of 295 kDa and is capable of oxidizing a variety of aldehydes. (jneurosci.org)
NADH1
- Also may catalyze nitric oxide (NO) production via the reduction of nitrite to NO with NADH or aldehyde as electron donor. (mybiosource.com)
Amine1
- The reaction mechanism for the palladium and amine cocatalyzed carbocyclization of aldehydes with alkynes has been investigated by means of density functional theory calculations and experiments. (diva-portal.org)
Inhibitor4
- Allopurinol is a xanthine oxidase inhibitor. (nih.gov)
- Raloxifene has also been shown to be a noncompetitive inhibitor of an aldehyde oxidase-catalyzed reduction reaction of a hydroxamic acid-containing compound, with a K i of 51 nM. (aspetjournals.org)
- Structural insights into xenobiotic and inhibitor binding to human aldehyde oxidase. (proteopedia.org)
- To test this, hydralazine (HYD), a potent aldehyde oxidase inhibitor, was administered orally to NAFL model rats. (elsevier.com)
Abscisic aldehyde2
- EC 1.2.3.1) catalyzes the final step of abscisic acid (ABA) biosynthesis, which is the oxidation of abscisic aldehyde (ABAld) to ABA. (usda.gov)
- The results of this work are discussed in the context of previous genetic and biochemical evidence regarding ABA biosynthesis, confirming the xanthoxin→abscisic aldehyde→ABA transition as the last steps of the major ABA biosynthetic pathway. (plantcell.org)
Hydrogen peroxide1
- AO catalyzes the conversion of an aldehyde in the presence of oxygen and water to an acid and hydrogen peroxide. (wikipedia.org)
Activity5
- primarily to differences of aldehyde oxidase activity. (symptoma.com)
- Distribution of aldehyde oxidase activity in larval tissues of closely related species reveals differences in tissue-specific expression which must be regulatory. (ucf.edu)
- The loss of aldehyde oxidase activity does not appear to cause any health problems. (medlineplus.gov)
- Aldehyde Oxidase Activity and Stability in Water-Miscible Organic Solvents. (biomedsearch.com)
- however, allopurinol is not converted in patients with type II, who lack aldehyde oxidase activity. (medscape.com)
Electron1
- AO has a higher affinity for aldehydes than purines, but produces O in a manner very similar to XO because both oxidases possess nearly identical internal electron transport systems. (bio-medicine.org)
Metabolic1
- Drugs for which aldehyde oxidase plays the predominant role in metabolic clearance are few. (aspetjournals.org)
NADPH1
- The involvement of the NADPH oxidase system, nitric oxide synthase system, and xanthine oxidase system are also described. (symptoma.com)
Dehydrogenases1
- In Arthrobacter globiformis , DMG demethylation to sarcosine is catalyzed by a DMG oxidase with similarity to eukaryotic DMG dehydrogenases ( 24 ). (asm.org)
Hydroxylase1
- Also known as Aldehyde oxidase (Aldehyde oxidase 1) (Azaheterocycle hydroxylase). (mybiosource.com)
Catalysis1
- The relevance of these data to the mechanistic understanding of aldehyde oxidase catalysis, as well as to the potential for raloxifene to cause drug interactions with agents for which aldehyde oxidase-mediated metabolism is important, such as zaleplon or famciclovir, is discussed. (aspetjournals.org)
Tissues1
- Aldehyde oxidase (AO) has been detected histochemically in selected larval tissues and imaginal discs of ten picture-winged Hawaiian Drosophila species chosen to represent four cytological subgroups. (ucf.edu)