Ethanol: A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant. It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as the primary ingredient in ALCOHOLIC BEVERAGES.Alcohol Deterrents: Substances interfering with the metabolism of ethyl alcohol, causing unpleasant side effects thought to discourage the drinking of alcoholic beverages. Alcohol deterrents are used in the treatment of alcoholism.Temperance: Habitual moderation in the indulgence of a natural appetite, especially but not exclusively the consumption of alcohol.Child of Impaired Parents: Child with one or more parents afflicted by a physical or mental disorder.National Institute on Alcohol Abuse and Alcoholism (U.S.): Component of the NATIONAL INSTITUTES OF HEALTH. It conducts research focused on improving the treatment and prevention of alcoholism and alcohol-related problems to reduce the health, social, and economic consequences of this disease. NIAAA, NIMH, and NIDA were created as coequal institutes within the Alcohol, Drug Abuse and Mental Health Administration in 1974. It was established within the NATIONAL INSTITUTES OF HEALTH in 1992.Bile Canaliculi: Minute intercellular channels that occur between liver cells and carry bile towards interlobar bile ducts. Also called bile capillaries.Alcoholics: Persons who have a history of physical or psychological dependence on ETHANOL.Alcohol-Induced Disorders, Nervous System: Acute and chronic neurologic disorders associated with the various neurologic effects of ETHANOL. Primary sites of injury include the brain and peripheral nerves.Disulfiram: A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase.Naltrexone: Derivative of noroxymorphone that is the N-cyclopropylmethyl congener of NALOXONE. It is a narcotic antagonist that is effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of heroin addiction. The FDA has approved naltrexone for the treatment of alcohol dependence.Alcoholic Intoxication: An acute brain syndrome which results from the excessive ingestion of ETHANOL or ALCOHOLIC BEVERAGES.Liver Cirrhosis, Alcoholic: FIBROSIS of the hepatic parenchyma due to chronic excess ALCOHOL DRINKING.Warts: Benign epidermal proliferations or tumors; some are viral in origin.Alcoholics Anonymous: An organization of self-proclaimed alcoholics who meet frequently to reinforce their practice of abstinence.Alcohol Withdrawal Delirium: An acute organic mental disorder induced by cessation or reduction in chronic alcohol consumption. Clinical characteristics include CONFUSION; DELUSIONS; vivid HALLUCINATIONS; TREMOR; agitation; insomnia; and signs of autonomic hyperactivity (e.g., elevated blood pressure and heart rate, dilated pupils, and diaphoresis). This condition may occasionally be fatal. It was formerly called delirium tremens. (From Adams et al., Principles of Neurology, 6th ed, p1175)Antisocial Personality Disorder: A personality disorder whose essential feature is a pervasive pattern of disregard for, and violation of, the rights of others that begins in childhood or early adolescence and continues into adulthood. The individual must be at least age 18 and must have a history of some symptoms of CONDUCT DISORDER before age 15. (From DSM-IV, 1994)Behavior, Addictive: The observable, measurable, and often pathological activity of an organism that portrays its inability to overcome a habit resulting in an insatiable craving for a substance or for performing certain acts. The addictive behavior includes the emotional and physical overdependence on the object of habit in increasing amount or frequency.Aldehyde Dehydrogenase: An enzyme that oxidizes an aldehyde in the presence of NAD+ and water to an acid and NADH. This enzyme was formerly classified as EC 1.1.1.70.Alcohol Dehydrogenase: A zinc-containing enzyme which oxidizes primary and secondary alcohols or hemiacetals in the presence of NAD. In alcoholic fermentation, it catalyzes the final step of reducing an aldehyde to an alcohol in the presence of NADH and hydrogen.Substance Withdrawal Syndrome: Physiological and psychological symptoms associated with withdrawal from the use of a drug after prolonged administration or habituation. The concept includes withdrawal from smoking or drinking, as well as withdrawal from an administered drug.Alcohol Amnestic Disorder: A mental disorder associated with chronic ethanol abuse (ALCOHOLISM) and nutritional deficiencies characterized by short term memory loss, confabulations, and disturbances of attention. (Adams et al., Principles of Neurology, 6th ed, p1139)Psychoses, Alcoholic: A group of mental disorders associated with organic brain damage and caused by poisoning from alcohol.Alcohol Withdrawal Seizures: A condition where seizures occur in association with ethanol abuse (ALCOHOLISM) without other identifiable causes. Seizures usually occur within the first 6-48 hours after the cessation of alcohol intake, but may occur during periods of alcohol intoxication. Single generalized tonic-clonic motor seizures are the most common subtype, however, STATUS EPILEPTICUS may occur. (Adams et al., Principles of Neurology, 6th ed, p1174)Alcohol-Related Disorders: Disorders related to or resulting from abuse or mis-use of alcohol.Alcohol-Induced Disorders: Disorders stemming from the misuse and abuse of alcohol.Marital Therapy: A form of psychotherapy involving the husband and wife and directed to improving the marital relationship.Father-Child Relations: Interaction between the father and the child.Genetic Predisposition to Disease: A latent susceptibility to disease at the genetic level, which may be activated under certain conditions.Liver Diseases, Alcoholic: Liver diseases associated with ALCOHOLISM. It usually refers to the coexistence of two or more subentities, i.e., ALCOHOLIC FATTY LIVER; ALCOHOLIC HEPATITIS; and ALCOHOLIC CIRRHOSIS.OklahomaSubstance-Related Disorders: Disorders related to substance abuse.Acetaldehyde: A colorless, flammable liquid used in the manufacture of acetic acid, perfumes, and flavors. It is also an intermediate in the metabolism of alcohol. It has a general narcotic action and also causes irritation of mucous membranes. Large doses may cause death from respiratory paralysis.Diagnostic and Statistical Manual of Mental Disorders: Categorical classification of MENTAL DISORDERS based on criteria sets with defining features. It is produced by the American Psychiatric Association. (DSM-IV, page xxii)Impulsive Behavior: An act performed without delay, reflection, voluntary direction or obvious control in response to a stimulus.Lipomatosis, Multiple Symmetrical: A condition characterized by the growth of unencapsulated masses of ADIPOSE TISSUE symmetrically deposited around the neck, shoulders, or other sites around the body.Family Health: The health status of the family as a unit including the impact of the health of one member of the family on the family as a unit and on individual family members; also, the impact of family organization or disorganization on the health status of its members.Risk Factors: An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.Fathers: Male parents, human or animal.Pellagra: A disease due to deficiency of NIACIN, a B-complex vitamin, or its precursor TRYPTOPHAN. It is characterized by scaly DERMATITIS which is often associated with DIARRHEA and DEMENTIA (the three D's).Microdissection: The performance of dissections with the aid of a microscope.Bartonella quintana: A species of gram-negative bacteria in which man is the primary host and the human body louse, Pediculus humanus, the principal vector. It is the etiological agent of TRENCH FEVER.Solar System: The group of celestial bodies, including the EARTH, orbiting around and gravitationally bound by the sun. It includes eight planets, one minor planet, and 34 natural satellites, more than 1,000 observed comets, and thousands of lesser bodies known as MINOR PLANETS (asteroids) and METEOROIDS. (From Academic American Encyclopedia, 1983)MMPI: A personality inventory consisting of statements to be asserted or denied by the individual. The patterns of response are characteristic of certain personality attributes.Genetic Linkage: The co-inheritance of two or more non-allelic GENES due to their being located more or less closely on the same CHROMOSOME.Brain: The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.Ethnology: The comparative and theoretical study of culture, often synonymous with cultural anthropology.Thiamine: 3-((4-Amino-2-methyl-5-pyrimidinyl)methyl)-5-(2- hydroxyethyl)-4-methylthiazolium chloride.Thiamine Deficiency: A nutritional condition produced by a deficiency of THIAMINE in the diet, characterized by anorexia, irritability, and weight loss. Later, patients experience weakness, peripheral neuropathy, headache, and tachycardia. In addition to being caused by a poor diet, thiamine deficiency in the United States most commonly occurs as a result of alcoholism, since ethanol interferes with thiamine absorption. In countries relying on polished rice as a dietary staple, BERIBERI prevalence is very high. (From Cecil Textbook of Medicine, 19th ed, p1171)United States Substance Abuse and Mental Health Services Administration: An agency of the PUBLIC HEALTH SERVICE concerned with the overall planning, promoting, and administering of programs pertaining to substance abuse and mental health. It is commonly referred to by the acronym SAMHSA. On 1 October 1992, the United States Alcohol, Drug Abuse, and Mental Health Administration (ADAMHA) became SAMHSA.Chromosomes, Human, Pair 4: A specific pair of GROUP B CHROMOSOMES of the human chromosome classification.Electroencephalography: Recording of electric currents developed in the brain by means of electrodes applied to the scalp, to the surface of the brain, or placed within the substance of the brain.Monoamine Oxidase: An enzyme that catalyzes the oxidative deamination of naturally occurring monoamines. It is a flavin-containing enzyme that is localized in mitochondrial membranes, whether in nerve terminals, the liver, or other organs. Monoamine oxidase is important in regulating the metabolic degradation of catecholamines and serotonin in neural or target tissues. Hepatic monoamine oxidase has a crucial defensive role in inactivating circulating monoamines or those, such as tyramine, that originate in the gut and are absorbed into the portal circulation. (From Goodman and Gilman's, The Pharmacological Basis of Therapeutics, 8th ed, p415) EC 1.4.3.4.Genome, Bacterial: The genetic complement of a BACTERIA as represented in its DNA.United States Dept. of Health and Human Services: A cabinet department in the Executive Branch of the United States Government concerned with administering those agencies and offices having programs pertaining to health and human services.Stress Disorders, Traumatic: Anxiety disorders manifested by the development of characteristic symptoms following a psychologically traumatic event that is outside the normal range of usual human experience. Symptoms include re-experiencing the traumatic event, increased arousal, and numbing of responsiveness to or reduced involvement with the external world. Traumatic stress disorders can be further classified by the time of onset and the duration of these symptoms.Polymorphism, Single Nucleotide: A single nucleotide variation in a genetic sequence that occurs at appreciable frequency in the population.Sex Factors: Maleness or femaleness as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or effect of a circumstance. It is used with human or animal concepts but should be differentiated from SEX CHARACTERISTICS, anatomical or physiological manifestations of sex, and from SEX DISTRIBUTION, the number of males and females in given circumstances.Cardiomyopathy, Alcoholic: Disease of CARDIAC MUSCLE resulting from chronic excessive alcohol consumption. Myocardial damage can be caused by: (1) a toxic effect of alcohol; (2) malnutrition in alcoholics such as THIAMINE DEFICIENCY; or (3) toxic effect of additives in alcoholic beverages such as COBALT. This disease is usually manifested by DYSPNEA and palpitations with CARDIOMEGALY and congestive heart failure (HEART FAILURE).Hand DermatosesAnalysis of Variance: A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.Case-Control Studies: Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.Wernicke Encephalopathy: An acute neurological disorder characterized by the triad of ophthalmoplegia, ataxia, and disturbances of mental activity or consciousness. Eye movement abnormalities include nystagmus, external rectus palsies, and reduced conjugate gaze. THIAMINE DEFICIENCY and chronic ALCOHOLISM are associated conditions. Pathologic features include periventricular petechial hemorrhages and neuropil breakdown in the diencephalon and brainstem. Chronic thiamine deficiency may lead to KORSAKOFF SYNDROME. (Adams et al., Principles of Neurology, 6th ed, pp1139-42; Davis & Robertson, Textbook of Neuropathology, 2nd ed, pp452-3)Gypsies: Ethnic group originating in India and entering Europe in the 14th or 15th century.Genome-Wide Association Study: An analysis comparing the allele frequencies of all available (or a whole GENOME representative set of) polymorphic markers in unrelated patients with a specific symptom or disease condition, and those of healthy controls to identify markers associated with a specific disease or condition.Psychiatric Status Rating Scales: Standardized procedures utilizing rating scales or interview schedules carried out by health personnel for evaluating the degree of mental illness.Endophenotypes: Measurable biological (physiological, biochemical, and anatomical features), behavioral (psychometric pattern) or cognitive markers that are found more often in individuals with a disease than in the general population. Because many endophenotypes are present before the disease onset and in individuals with heritable risk for disease such as unaffected family members, they can be used to help diagnose and search for causative genes.Delta Rhythm: Brain waves seen on EEG characterized by a high amplitude and a frequency of 4 Hz and below. They are considered the "deep sleep waves" observed during sleep in dreamless states, infancy, and in some brain disorders.Comorbidity: The presence of co-existing or additional diseases with reference to an initial diagnosis or with reference to the index condition that is the subject of study. Comorbidity may affect the ability of affected individuals to function and also their survival; it may be used as a prognostic indicator for length of hospital stay, cost factors, and outcome or survival.Receptors, Corticotropin-Releasing Hormone: Cell surface proteins that bind corticotropin-releasing hormone with high affinity and trigger intracellular changes which influence the behavior of cells. The corticotropin releasing-hormone receptors on anterior pituitary cells mediate the stimulation of corticotropin release by hypothalamic corticotropin releasing factor. The physiological consequence of activating corticotropin-releasing hormone receptors on central neurons is not well understood.Phenotype: The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.Lod Score: The total relative probability, expressed on a logarithmic scale, that a linkage relationship exists among selected loci. Lod is an acronym for "logarithmic odds."Substance Abuse Treatment Centers: Health facilities providing therapy and/or rehabilitation for substance-dependent individuals. Methadone distribution centers are included.Frontal Lobe: The part of the cerebral hemisphere anterior to the central sulcus, and anterior and superior to the lateral sulcus.Character: In current usage, approximately equivalent to personality. The sum of the relatively fixed personality traits and habitual modes of response of an individual.Cooperative Behavior: The interaction of two or more persons or organizations directed toward a common goal which is mutually beneficial. An act or instance of working or acting together for a common purpose or benefit, i.e., joint action. (From Random House Dictionary Unabridged, 2d ed)Myelinolysis, Central Pontine: A demyelinating condition affecting the PONS and characterized clinically by an acute progressive QUADRIPLEGIA; DYSARTHRIA; DYSPHAGIA; and alterations of consciousness. Pathologic features include prominent demyelination in the central PONS with sparing of axons and neurons. This condition is usually associated with systemic disorders such as HYPONATREMIA; chronic ALCOHOLISM; LIVER FAILURE; severe BURNS; malignant NEOPLASMS; hemorrhagic PANCREATITIS; HEMODIALYSIS; and SEPSIS. The rapid medical correction of hyponatremia has been cited as a cause of this condition. (From Adams et al., Principles of Neurology, 6th ed, pp1125-6)Indians, North American: Individual members of North American ethnic groups with ancient historic ancestral origins in Asia.

Lymphocyte proliferation inhibitory factor (PIF) in alcoholic liver disease. (1/5630)

Lymphocyte proliferation inhibitory factor (PIF) was determined in the supernatants of PHA-stimulated lymphocytes from patients with alcoholic liver disease. PIF was assayed by determining inhibition of DNA synthesis in WI-38 human lung fibroblasts. A two-fold greater inhibition in thymidine incorporation into DNA by lung fibroblasts was observed in supernatants of PHA stimulated lymphocytes from patients with alcoholic hepatitis or active Laennec's cirrhosis as compared with that found in control subjects or patients with fatty liver. It is suggested that decreased liver cell regeneration seen in some patients with alcoholic hepatitis may be due to increased elaboration of PIF.  (+info)

Antibodies against phospholipids and oxidized LDL in alcoholic patients. (2/5630)

Antiphospholipid antibodies (APA) are a generic term describing antibodies that recognize various phospholipids. Hepatocyte damage is a cardinal event in the course of alcoholic liver injury and autoantibodies against phospholipids could play an important role in this process. APA in alcoholic patients seem to reflect membrane lesions, impairment of immunological reactivity, liver disease progression and they correlate significantly with disease severity. LDL oxidation is supposed to be one of the most important pathogenic mechanisms of atherosclerosis and antibodies against oxidized low-density lipoprotein (oxLDL) are some kind of an epiphenomenon of this process. The scope of our study was to determine some autoantibodies (IgG-oxLDL and antiphospholipid antibodies) and their possible changes in alcoholic patients. We studied IgG-oxLDL and four APA - anticardiolipin antibodies (ACA), antiphosphatidylserine antibodies (APSA) antiphosphatidylethanolamine antibodies (APE) and antiphosphatidylcholine antibodies (APCA) in 35 alcoholic patients with mildly affected liver function at the beginning of the abuse treatment. The control group consisted of 60 healthy blood donors. In the studied group, we obtained positive results concerning total ACA in 17.1 % of alcoholic patients (8.3 % in the control group), 11.4 % IgG-ACA (6.7 %), 8.6 % IgM-ACA (3.3 %), 14.3 % total APE (6.7 %), 14.3 % total APCA (8.3 %) and 20 % total APSA (8.3 % in the control group). The IgG-oxLDL (406.4+/-52.5 vs 499.9+/-52.5 mU/ml) was not affected in alcoholic patients. We conclude that the autoantibodies against oxLDL are present in sera of alcoholics and healthy blood donors. Based on our results which revealed a wide range of IgG-oxLDL titres in the healthy population, this parameter does not appear to be very promising for the evaluation of the risk of atherosclerosis. Alcoholics with only mild affection of liver functions did not exhibit a significantly higher prevalence of all studied antiphospholipid antibodies (ACA, APSA, APE, APCA) which could lead to membrane lesions in these patients.  (+info)

Involvement of cytochromes P-450 2E1 and 3A4 in the 5-hydroxylation of salicylate in humans. (3/5630)

Hydroxylation of salicylate into 2,3 and 2,5-dihydroxybenzoic acids (2,3-DHBA and 2,5-DHBA) by human liver microsomal preparations was investigated. Kinetic studies demonstrated that salicylate was 5-hydroxylated with two apparent Km: one high-affinity Km of 606 microM and one low-affinity Km greater than 2 mM. Liver microsomes prepared from 15 human samples catalyzed the formation of 2,5-DHBA at metabolic rate of 21.7 +/- 8.5 pmol/mg/min. The formation of 2, 3-DHBA was not P-450 dependent. Formation of 2,5-DHBA was inhibited by 36 +/- 14% following preincubation of microsomes with diethyldithiocarbamate, a mechanism-based selective inhibitor of P-450 2E1. Furthermore, the efficiency of inhibition was significantly correlated with four catalytic activities specific to P-450 2E1, whereas the residual activity was correlated with three P-450 3A4 catalytic activities. Troleandomycin, a mechanism-based inhibitor selective to P-450 3A4, inhibited by 30 +/- 12% the 5-hydroxylation of salicylate, and this inhibition was significantly correlated with nifedipine oxidation, specific to P-450 3A4. The capability of seven recombinant human P-450s to hydroxylate salicylate demonstrated that P-450 2E1 and 3A4 contributed to 2, 5-DHBA formation in approximately equal proportions. The Km values of recombinant P-450 2E1 and 3A4, 280 and 513 microM, respectively, are in the same range as the high-affinity Km measured with human liver microsomes. The plasmatic metabolic ratio 2,5-DHBA/salicylate, measured 2 h after ingestion of 1 g acetylsalicylate, was increased 3-fold in 12 alcoholic patients at the beginning of their withdrawal period versus 15 control subjects. These results confirm that P-450 2E1, inducible by ethanol, is involved in the 5-hydroxylation of salicylate in humans. Furthermore, this ratio was still increased by 2-fold 1 week after ethanol withdrawal. This finding suggests that P-450 3A4, known to be also inducible by alcoholic beverages, plays an important role in this increase, because P-450 2E1 returned to normal levels in less than 3 days after ethanol withdrawal. Finally, in vivo and in vitro data demonstrated that P-450 2E1 and P-450 3A4, both inducible by alcohols, catalyzed the 5-hydroxylation of salicylate.  (+info)

The role of gamma-hydroxybutyric acid in the treatment of alcoholism: from animal to clinical studies. (4/5630)

Since its discovery nearly 40 years ago, gamma-hydroxybutyric acid (GHB) has attracted several waves of scientific interest due to new developments in the knowledge of its mechanisms of action and ideas for its potential use in clinical practice. Its effects have been claimed to treat different psychiatric conditions, but over time its use has become limited to a few specific situations (e.g. sedating patients in non-painful surgical procedures and narcolepsy). New interest in the drug derives from its potential use in the treatment of alcoholism. Recent studies demonstrated a marked effect of the substance in suppressing ethanol (ETOH) withdrawal symptoms and in reducing craving for alcohol, compared to other available drugs. However, GHB has to be given under very careful supervision because of its side-effects, including the risk of abuse and dependence and possible interference with the metabolic pathways of endogenous GHB and ETOH. This short review discusses these and related issues and we hope that it will stimulate further interest in GHB.  (+info)

The impact of Alcohol and Alcoholism among substance abuse journals. (5/5630)

This article concerns the question of journal impact factor and other bibliometric indicators made available by the Institute for Scientific Information in their Journal Citation Report for 1996. The impact factors of journals within the subject category 'substance abuse' are listed along with total citations, immediacy indices, and cited half-lives. The relationship between cited and citing journals is discussed with the main focus on the data available for Alcohol and Alcoholism. Some of the problems and limitations of bibliometric measures of productivity are dealt with, especially when these are used to evaluate the work of individual scientists. Although bibliometric measures are easy to compute, they become difficult to interpret, such as when dealing with collaborative research and the problem posed by multiple authorship. The need to adjust impact factors and citation counts for the number of co-authors in a paper becomes important when credit has to be attributed to one individual from a multi-author paper. This is often necessary in connection with grant applications and when making decisions about academic promotion and tenure. The impact factor of Alcohol and Alcoholism has increased steadily over the past 5 years, even after adjusting for the number of self-citations, which resulted in an even greater increase in impact. However, the impact factors of substance abuse journals are generally low, compared with disciplines such as immunology, genetics, and biochemistry. Some suggestions are made for increasing the impact factors of substance abuse journals if this is considered necessary. But instead of paying attention to the impact factor of a journal, scientists should give more consideration to the speed and efficiency of the editorial handling of their manuscripts and particularly to the quality and timeliness of the peer review.  (+info)

Enhancing the identification of excessive drinkers on medical wards: a 1-year follow-up study. (6/5630)

This paper describes a 1-year follow-up study examining whether hospital ward doctors and nurses continue to take quantitative alcohol histories and provide brief intervention to problem drinkers on general medical wards after the introduction of a simple protocol. Regular training in the use of this protocol was stipulated in the annual service contract between the Health Authority and the Hospital Trusts. Improvements in staff practice persisted at 1-year follow-up, although it fell from a peak at an earlier phase of the study. The positive role of state purchasers of health services in sustaining improvements in clinical practice is discussed.  (+info)

Urban-rural comparisons of drink-driving behaviour among late teens: a preliminary investigation. (7/5630)

A preliminary study was conducted to examine the nature and extent of urban-rural differences in self-reported drinking and driving among youths in Western Australia. A total of 102 youths aged 17, 18 and 19 years were surveyed via a random street sampling technique about their alcohol consumption and drink-driving behaviour. Analyses indicated that urban youths had a significantly higher level of self-reported drink-driving behaviour than their rural counterparts. Males indicated a higher level of self-reported drink-driving behaviour than females. This article also provides a review and summary of youth drink-driving literature with special focus on urban-rural comparisons.  (+info)

Alcohol consumption profile by time in middle-aged men: a longitudinal study based on three different diagnostic instruments. (8/5630)

This longitudinal study aimed at comparing aggregate measures of heavy or problem drinking and their variations across time among the same subjects. We examined middle-aged men participating in a health survey over a 5-year interval. Of the 133 consecutive men in the whole age group interviewed as 40-year-olds in 1989, 114 were reached and re-interviewed in 1994. Alcohol consumption was measured by self-report, Malmo-modified Michigan Alcoholism Screening Test (Mm-MAST), and serum carbohydrate-deficient transferrin (CDT). Self-reported alcohol consumption decreased with years (142 vs 105 g/week, P = 0.01), as did CDT (16.9 vs 14.4 U/l, P = 0.02), but there was no change in the Mm-MAST results. There was no significant difference in the number of heavy drinkers (either Mm-MAST score > or = 3, or by self-reported alcohol consumption > or = 280 g/week, or by CDT > or = 20 U/l) at 40 and 45 years of age (37 and 47% respectively). At the individual level, alcohol consumption both increased and decreased with age. At 45 years of age 5/114 (4%) of the men reported that they had increased their alcohol consumption by more than 80 g/week and 25/114 (22%) said that they had reduced their drinking by the same amount. The remaining 84 (74%) reported drinking the same amount as 5 years earlier (+/- 80 g/week). This indicates that alcohol drinking habits are not stable in middle age. Most heavy drinkers in both age groups were detected by Mm-MAST and this proportion increased with age while the proportion of positive self-reports and CDTs decreased. Thus, the social consequences, measured here by the Mm-MAST, may be more readily experienced with years even at smaller consumption levels.  (+info)

*ADH1B

This SNP may be related to alcohol consumption with the atypical genotype having reduced risk of alcoholism. Another SNP is ...

*Post-acute-withdrawal syndrome

Beleslin D (1991). "[Modern drug therapy in alcoholism]". Med Pregl. 44 (7-8): 279-84. PMID 1806768. Wilde MI; Wagstaff AJ ( ... "Comparative Efficiency of Proproten-100 during the Therapy of Patients with Alcoholism in the Stage of Therapeutic Remission". ... "Co-occurring psychiatric disorders and alcoholism". Handb Clin Neurol. 125: 573-88. doi:10.1016/B978-0-444-62619-6.00033-1. ...

*Alcohol dehydrogenase

If the variants of these genes encode slower metabolizing forms of ADH2 and ADH3, there is increased risk of alcoholism. The ... A study was conducted in order to find a correlation between allelic distribution and alcoholism, and the results suggest that ... The results of increased alcohol availability led to alcoholism and abuse by those able to acquire it, resulting in lower ... However, research continues in order to identify the genes and their influence on alcoholism. Drug dependence is another ...

*Alcohol withdrawal syndrome

In the Western world about 15% of people have problems with alcoholism at some point in time. About half of people with ... Kissin, Benjamin; Begleiter, Henri (2013). The Biology of Alcoholism: Volume 3: Clinical Pathology. Springer Science & Business ... protracted abstinence and negative affect in alcoholism: are they linked?". Addict Biol. 15 (2): 169-84. doi:10.1111/j.1369- ... "Neurobiological and neurocognitive effects of chronic cigarette smoking and alcoholism". Front. Biosci. 12 (8-12): 4079-100. ...

*Alcoholism

The term alcoholism is commonly used amongst laypeople, but the word is poorly defined. The WHO calls alcoholism "a term of ... Treatments are varied because there are multiple perspectives of alcoholism. Those who approach alcoholism as a medical ... With regard to alcoholism, BAC is useful to judge alcohol tolerance, which in turn is a sign of alcoholism. However, none of ... "alcoholism". That term now has a more specific meaning. The term "alcoholism" was first used in 1849 by the Swedish physician ...

*Alcoholism Treatment Quarterly

The Alcoholism Treatment Quarterly is a quarterly peer-reviewed medical journal published by Taylor & Francis. The editor-in- ... Alcoholism Treatment Quarterly. Taylor & Francis. Retrieved 7 September 2014. PsychINFO Journal Coverage, American ...

*Alcohol and Alcoholism

... is a bimonthly peer-reviewed medical journal covering alcoholism and other health effects of alcohol. It ... In 1968, it was renamed the Journal of Alcoholism, and in 1977, it was again renamed, this time to British Journal on Alcohol ... It is the official journal of both the MCA and the European Society for Biomedical Research on Alcoholism. The editors-in-chief ... British Journal on Alcohol and Alcoholism. 17 (4): 125-127. "Oxford University Press and Medical Council on Alcohol announce ...

*Alcoholism in adolescence

Alcoholism throughout adolescents is increasing yearly for a number of different reasons. These reasons include: Availability ... Alcoholism: Clinical and Experimental Research, 38: 1622-1629. doi: 10.1111/acer.12404 Foltran, F., Gregori, D., Franchin, L., ... Another important component to preventing alcoholism throughout adolescence is the responsibility of the government, to send a ... of alcohol Peer pressure Role model Television Anxiety or stress There are a number of ways to preventing alcoholism throughout ...

*College student alcoholism

56% of students reported binge drinking once a week.In comparison, the comparable figure of alcoholism for American Indian and ... National Institute on Alcohol Abuse and Alcoholism (NIAAA) reported in 2012, that more than 80% of college students drink ... Alcohol use among college students Alcohol advertising on college campuses American Indian alcoholism Cigarette smoking among ...

*Research Society on Alcoholism

... Retrieved 2011-02-13. "Journal Information". Alcoholism: Clinical and Experimental Research. ... The Research Society on Alcoholism (RSA) is a learned society of over 1600 active members based in Austin, Texas. Its objective ... The RSA holds an annual meeting and, together with the International Society for Biomedical Research on Alcoholism, sponsors ... the publication of Alcoholism: Clinical and Experimental Research, published by Wiley-Blackwell. RSA holds yearly elections for ...

*Disease theory of alcoholism

Managing Alcoholism as a Disease. Physician's News Digest, 1998 "Alcoholics Anonymous. What Is Alcoholism?". Archived from the ... The risk of developing alcoholism depends on many factors, such as environment. Those with a family history of alcoholism are ... NIH/National Institute on Alcohol Abuse and Alcoholism. 2001-2002 Survey Finds That Many Recover From Alcoholism: Researchers ... "Many doctors have been loath to prescribe drugs to treat alcoholism, sometimes because of the belief that alcoholism is a moral ...

*Alcoholism in family systems

... refers to the conditions in families that enable alcoholism, and the effects of alcoholic behavior ... Alcoholism is more prevalent among child abusing parents. Alcoholism is more strongly correlated to child abuse than depression ... Research shows that ACOAs feel less like blaming their parents for their alcoholism after learning that alcoholism is a disease ... Cermak, TL (1989). "Al-Anon and recovery". Recent developments in alcoholism. Recent Developments in Alcoholism. 7: 91-104. doi ...

*Michigan Alcoholism Screening Test

The Michigan Alcoholism Screening Test (MAST) screening tool was developed in 1971 and is one of the oldest alcoholism ... access-date= requires ,url= (help) Shields, A.L.; Howell, R. T.; Potter, J.; Weiss, R. D. (2007). "The Michigan Alcoholism ...

*World League Against Alcoholism

... the World League Against Alcoholism not only sought to prevent alcoholism but any consumption of alcoholic beverages. Following ... The World League Against Alcoholism was organized by the Anti-Saloon League, whose goal became establishing prohibition not ... Anti-Saloon leader Ernest Cherrington promoted creation of the World League Against Alcoholism. Created in 1919, the new ... League's fortunes fell dramatically and it found itself unable to continue supporting the World League Against Alcoholism. ...

*Alcoholism: Clinical and Experimental Research

... is a scientific journal covering research concerning alcohol abuse and its ... It is published by Wiley-Blackwell on behalf of the Research Society on Alcoholism and the International Society for Biomedical ... Research on Alcoholism. The journal is abstracted and indexed in Academic Search, Current Awareness in Biological Sciences, ... ". "Journal Information". Alcoholism: Clinical and Experimental Research. Wiley-Blackwell. Archived from the original on 30 ...

*Molecular and epigenetic mechanisms of alcoholism

... which could lead to therapeutic targets for alcoholism. Treatments for alcoholism aim to end ethanol consumption and provide ... In Alcoholism (p. 14). Santa Barbara, Calif.: Greenwood Press/ABC-CLIO. Bolanos, C. A. and Nestler, E. J. (2004). Neurotrophic ... Alcoholism: Clinical and Experimental Research, 27(3), 396-409. Pandey, S.C., Roy, A., Mittal, N. (2001). Effects of chronic ... Whether or not tolerance and alcoholism are related is still under debate. Further work must be done in order to find a ...

*The Natural History of Alcoholism Revisited

"Alcoholism." Emedicine.com. Etiology and Natural History of Alcoholism. National Institute on Alcohol Abuse and Alcoholism.. ... "Alcoholism can simultaneously reflect both a conditioned habit and a disease." Factors predicting alcoholism were related to ... Depression, clinically so often found to occur with alcoholism, was likewise found to be a result of alcoholism. Evidence such ... Unhappy family environments caused alcoholism only if the unhappy environments were the result of alcoholism in the first place ...

*National Council on Alcoholism and Drug Dependence

"National Council on Alcoholism and Drug Dependence - NCADD - fights the stigma and the disease of alcoholism and other drug ... The National Council on Alcoholism and Drug Dependence (NCADD) is an American advocacy organization focused on alcoholism, drug ... Defined "alcoholism" as a disease and successfully worked for its adoption by the American Medical Association (AMA). Formed ... Successfully advocated for insurance coverage for alcoholism and addiction treatment equal to other illnesses. Alcohol and ...

*Collaborative Study on the Genetics of Alcoholism

In studying alcoholism, COGA hopes to find better ways of treating alcoholism and improving the lives of the millions of people ... The Collaborative Study on the Genetics of Alcoholism: An Update Alcoholism and Human Electrophysiology Defining Alcohol- ... and probably cause a susceptibility to alcoholism as well. COGA is attempting to find those chromosomes involved in alcoholism ... COGA's aim is to identify the genes involved in alcoholism. There is a large body of twin-studies and adoption-studies that ...

*National Institute on Alcohol Abuse and Alcoholism

The National Institute on Alcohol Abuse and Alcoholism (NIAAA), as part of the U.S. National Institutes of Health, supports and ... conducts biomedical and behavioral research on the causes, consequences, treatment, and prevention of alcoholism and alcohol- ...

*Propyphenazone/paracetamol/caffeine

... alcoholism; gastrointestinal ulcera or bleeding; pregnancy and lactation; infants and children under 6 to 12 years (varying by ...

*Lo que callamos las mujeres

Alcoholism; age disparities in sexual relationships; Corruption or Exploitation; Unjust firings; Diabetes; Male infertility; ...

*Alcohol advertising

Alcohol and Alcoholism 2011; 46: 210-13. Two articles among many are Effects of Alcohol Advertising Exposure on Drinking Among ... There have been various campaigns to help prevent alcoholism, under-age drinking and drunk driving. The Portman Group, an ... In: Wekesser, Carol (ed.) Alcoholism. San Diego, CA: Greenhaven Press, 1994. Pp. 132-135, p. 133. "Issues" at the Distilled ... Alcohol and Alcoholism. 44 (3): 229-243. doi:10.1093/alcalc/agn115. ISSN 0735-0414. PMID 19144976. Waiters, Elizabeth D.; Treno ...

*David J. Hanson

In: Roleff, T. (ed). Alcoholism. Detroit, MI: Greenhaven Press, 2010. Alcohol Advertising. In: Esposito, R. (ed). Mass Media. ... "Find Alcoholism Help" Disclaimer for the website "Alcohol Facts" Webpage about David J. Hanson Alcohol: Problems and Solutions ... Alcohol Facts Find Alcoholism Help Mangled Drunk Driving Data? - Dr. David J. Hanson interview Fox News: Lawsuits, Alcohol ...

*Richard R. Peabody

"Alcoholism". About.com. V., Diane. "History of the Program". A Friend of Bill W. Apopka, Florida. Archived from the original on ... He died of alcoholism at age 44. Born on 23 Jan 1892 to Jacob Crowninshield Rogers Peabody and Florence Dumaresq Wheatland, his ... He was the first authority to proclaim that there was no cure for alcoholism. His book became a best seller and was a major ... He was the first authority to assert there was no cure for alcoholism, writing in his book, His book became a best seller and ...
Chronic alcoholism medical definition Acute and chronic alcoholism definition Chronic alcoholism definition Definition of chronic alcoholism ➥ This article will describe the connection between alcohol and anemia and address how alcohol induced anemia can be prevented and treated. ➤ Chronic alcoholism medical definition Acute and chronic alcoholism definition Chronic alcoholism definition Definition of chronic alcoholism on the site ➦ alcohol-ism.info
Page 2 Ξ Alcoholism and depression Alcoholism and diabetes Alcoholism and genetics Alcoholism and dementia Alcoholism and anxiety Alcoholism and diarrhea Alcoholism and the brain Alcoholism and weight loss Alcoholism and anemia Alcoholism and pancreatitis Alcoholi ➥ Alcoholism and relapse ➥ Alcoholism 5 years ➥ Alcoholism and weight loss ➥ Alcoholism and yellow diarrhea ➥ Alcoholism 19th century ➥ Alcoholism and cramps ➥ Alcoholism and nervous system ➥ Alcoholism and the heart ➥ Alcoholism and depression Alcoholism and diabetes Alcoholism and genetics Alcoholism and dementia Alcoholism and anxiety Alcoholism and diarrhea Alcoholism and the brain Alcoholism and weight loss Alcoholism and anemia Alcoholism and pancreatitis Alcoholism and anger Alcoholism and addiction Alcoholism and abuse Alcoholism and adhd Alcoholism and ada Alcoholism and anorexia Alcoholism and anger issues Alcoholism and aging Alcoholism and afib Hepatitis a and alcoholism Vitamin a and alcoholism Alcoholism and a
The terms alcoholism and alcohol dependency are often used interchangeably. While both indicate a physical reliance upon alcohol, alcohol dependency is characterized by a dependence upon alcohol that results in physical withdrawal symptoms while alcoholism is an addiction to alcohol characterized by marked behavioral problems due to prolonged and excessive harmful use.
The terms alcoholism and alcohol dependency are often used interchangeably. While both indicate a physical reliance upon alcohol, alcohol dependency is characterized by a dependence upon alcohol that results in physical withdrawal symptoms while alcoholism is an addiction to alcohol characterized by marked behavioral problems due to prolonged and excessive harmful use.
Ethyl alcohol - the symptoms of alcohol dependency. To replace their God given spirit, begins with understanding at some level the symptoms of alcohol dependency and spirit to affect the symptoms of alcohol dependency and body coordinating connection. Look to breathing forms as force that works from the symptoms of alcohol dependency into the symptoms of alcohol dependency next of the symptoms of alcohol dependency about alcohol use if it wasnt a problem so they wont have to adjust to the symptoms of alcohol dependency, especially family members. Often the affected family members becoming desperate, angry, frustrated, nervous, afraid and guilty. In many ways they start behaving like the symptoms of alcohol dependency, even though they do not know how to feel and think within events of life experiences and other natural resources such as MADD, and school and college administrators.. When something like alcohol use if it wasnt a problem in their life to be connected with sexual assault. For ...
Ethyl alcohol - the symptoms of alcohol dependency. To replace their God given spirit, begins with understanding at some level the symptoms of alcohol dependency and spirit to affect the symptoms of alcohol dependency and body coordinating connection. Look to breathing forms as force that works from the symptoms of alcohol dependency into the symptoms of alcohol dependency next of the symptoms of alcohol dependency about alcohol use if it wasnt a problem so they wont have to adjust to the symptoms of alcohol dependency, especially family members. Often the affected family members becoming desperate, angry, frustrated, nervous, afraid and guilty. In many ways they start behaving like the symptoms of alcohol dependency, even though they do not know how to feel and think within events of life experiences and other natural resources such as MADD, and school and college administrators.. When something like alcohol use if it wasnt a problem in their life to be connected with sexual assault. For ...
Alcohol dependence is a heavy burden on patients, their families, and society. Epidemiological studies indicate that alcohol dependence will affect many individuals at some time in their lives, with men affected more frequently than women. Since alcohol-dependent patients often exhibit a lack of social skills and suffer from interpersonal problems, the aim of this study is to elucidate whether men and women experience the same interpersonal problems. Eighty-five alcohol-dependent patients (48 men; 37 women) after detoxification and 62 healthy controls (35 men; 27 women) were recruited. Interpersonal problems were measured with the Inventory of Interpersonal Problems (IIP-64). Additionally, alcohol-dependent patients were interviewed with the Alcohol Use Disorders Identification Test (AUDIT) and were subtyped according to Leschs Alcohol Typology (LAT). There were no significant gender differences in the AUDIT and LAT between alcohol-dependent men and women. Interpersonal problems of alcohol-dependent
Alcohol dependency is common, but it is also commonly overlooked. One reason why is that the negative symptoms of alcoholism are closely linked with other chronic health conditions and aging in general. If a woman over 65 imbibes in several drinks, then falls and is injured, the cause of the fall will likely be attributed to her age - even if it is more likely that alcohol caused the fall.. Likewise, medical issues such as headaches, fatigue, stomach pain, and depression are common symptoms of drinking to excess on a regular basis. Still, if these symptoms appear in older women, they are often written off as age-related.. Another reason for overlooking alcohol dependency in older women is that women are not largely thought of as having substance abuse problems. By contrast, men are generally the ones who end up on the receiving end of interventions and legal action because of their behavior while under the influence. It is generally accepted that if a man is seen overindulging in alcohol, he ...
There are lots of types of essays, so it isnt hard to eliminate an eye on all of your writing assignments.. For instance, an superb cause and effect article on alcoholism should start with a overview of alcoholism. You should briefly explain what the article is all about and how youre likely to be presenting it. If youre considering writing an general informative article on alcohol, then you are able to write about various forms of alcohol, the manner that it is prepared, distinct brands and prices etc.. If you do not find out how to start your essay or where to search for encouraging information, we are going to be delighted to help you.. If youre in need of a custom created essay on Alcoholism dont hesitate to contact our essay writing firm. A study paper on alcoholism should also consist of sources on the topic ...
Read this full essay on Alcohol Dependency. Alcohol Dependency Dependence is defined as a cluster of three or more existing criteria according to the ...
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If you or a loved one have been drinking too much or have experienced problems with alcoholism, you probably know a thing or two about the harmful short-term effects of alcohol abuse. There are the hangovers, the vomiting, the big red nose with the broken capillaries, the shakes. Theres the violence, too, and all the bad decisions you make. But you know all that. What you might not know is that alcohol addiction can have serious long-term effects on almost every system in your body.. Most people know that alcoholism can cause cirrhosis of the liver. But did you know that it can also lead to neuropathic disorders and stroke? Hepatitis is a major risk, as well as cancer of the mouth, throat, esophagus, breast, colon, and liver. Cardiovascular issues such as myocardial infarction, cardiomyopathy, atrial fibrillation, and hypertension are also extremely common among patients with alcohol dependency. Gastrointestinal problems such as gastritis and pancreatitis can also result. The fact is that ...
This report presents the findings of the 1987 National Drug and Alcoholism Treatment Unit Survey, a national survey designed to measure the location, scope, and characteristics of drug abuse and alcoholism treatment and prevention facilities, services, and activities throughout the United States, including the District of Columbia, and the U.S. territories. An introductory chapter describes the background of the survey, the report format, characteristics of the reporting base, and data considerations and limitations. Chapter 2 examines utilization rates, locations of units, unit ownership, unit orientation, the annual unduplicated count of clients, client demographics, type of care, services provided, and estimates of the number of intravenous drug users among both drug abuse and alcoholism clients. Chapter 3 presents data on drug abuse clients and chapter 4 examines alcoholism clients. Since separate client matrices were used to collect data on drug abuse and alcoholism clients,
Alcohol dependency It is not unusual to enjoy an alcoholic drink with friends etc, but drinking habits can become unhealthy without us noticing. Long-term heavy drinking or regular binge drinking … read more
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LONDON (Reuters) - A novel drug to fight alcohol dependency has been endorsed for use on Britains state health service by the countrys cost-effectiveness watchdog NICE in a boost to its Danish
Acamprosate has been shown to reduce drinking days in alcohol dependent patients and promote abstinence, with few reported side effects. A limitation of these studies, however, has been their lack of generalizability due to restrictive inclusion and exclusion criteria. Furthermore, most of the previous studies of acamprosate have been conducted in Europe, in a different treatment setting from the typical American Family Medicine center, where alcohol dependent patients are most likely to be first identified in the U.S.. The present study is designed to determine the efficacy of acamprosatefor alcohol dependence in a Family Medicine setting using minimal psychotherapeutic interventions-as would also likely occur in a primary care setting. The study will be a 12-week, double-blind, placebo-controlled, randomized trial comparing 666 mg acamprosate t.i.d. to placebo in patients at the UNC Family Medicine Center with alcohol dependence. Subjects will be seen by Family Medicine physicians and receive ...
Alcoholism Statistics. One of the most insightful ways to study alcoholism is to look at the main statistics on alcoholism that are available.
Some physicians, scientists and others have rejected the disease theory of alcoholism on logical, empirical and other grounds.[48][49][50][51][52][53] Indeed, some addiction experts such as Stanton Peele are outspoken in their rejection of the disease model, and other prominent alcohol researchers such as Nick Heather have authored books intending to disprove the disease model.[54] Some critics of the disease model argue alcoholism still involves choice, not total loss of control, and stripping alcohol abusers of their choice, by applying the disease concept, is a threat to the health of the individual; the disease concept gives the substance abuser an excuse. A disease cannot be cured by force of will; therefore, adding the medical label transfers the responsibility from the abuser to caregivers. Inevitably the abusers become unwilling victims, and just as inevitably they take on that role. They argue that the disease theory of alcoholism exists only to benefit the professionals and ...
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Poor response inhibition has been implicated in the development of alcohol dependence, yet little is known about how neural pathways underlying cognitive control are affected in this disorder. Moreover, endogenous opioid levels may impact the functionality of inhibitory control pathways. This study investigated the relationship between alcohol dependence severity and functional connectivity of fronto-striatal networks during response inhibition in an alcohol-dependent sample. A secondary aim of this study was to test the moderating effect of a functional polymorphism (A118G) of the μ-opioid receptor (OPRM1) gene. Twenty individuals with alcohol dependence (six females; 90% Caucasian; mean age = 29.4) who were prospectively genotyped on the OPRM1 gene underwent blood oxygen level-dependent functional magnetic resonance imaging while performing a Stop-Signal Task. The relationship between alcohol dependence severity and functional connectivity within fronto-striatal networks important for ...
People who are homosexual, bisexual or lesbian or who have had a same sex relationship in the past are 1.5 to 2x more likely to have experienced violent events during their childhood and have double the risk of experiencing post-traumatic stress disorder as a consequence of these events. Researchers from Harvard School of Public Health and the Childrens Hospital, Boston used data from the National Epidemiological Survey on Alcohol and Related Conditions and found that 48% of sexual minority women and 28% of sexual minority men experienced violence or abuse in childhood compared to 21% of women and 20% of men in the general population ...
5 Research on the Effectiveness of Alcoholism Treatment 5. Research on the Effectiveness of Alcoholism Treatment Despite the lack of well-controlled and generalizable research on the efficacy and effectiveness
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This method has proven to be reliable in helping people with alcoholism to overcome this habit and achieve complete abstinence. Others have shown a tendency to continue using the drugs they had been introduced to prior to alcohol consumption. Though they may not achieve total abstinence, they have exhibited a tendency of not relapsing to their former levels of alcoholism and therefore achieve their goals.. The Sinclair Method has proven to be popular with an increasing number of people seeking an inpatient alcohol abuse rehab. However, the fact that there still lacks enough studies conducted on the method means that not many rehab centers, especially those offering inpatient services, are willing to fully embrace, implement, and recommend it to their patients. Therefore, it is perceived that more time is required for it to gain widespread acceptance.. Patients undergoing inpatient rehab who exhibit acute withdrawal symptoms are given sodium oxybate to alleviate this problem. This drug also helps ...
Learn everything you need to know about the disease of alcoholism, also known as alcohol addiction. Find signs, symptoms and causes of alcohol addiction. Learn about treatment options and how alcoholics recover.
This study examined the potential mediating role of Ego Strength, Self-Esteem, and Negative Emotionality/neuroticism (NEGE) in the relationship between traumatic parental failures and childhood adversity on the development and severity of alcoholism, in a sample of 296 alcoholic and non-alcoholic Roman Catholic women Religious. Potential mediators and addiction severity were measured with the MMPI-2 subscales. The mediational model was tested using logistic regression, and the results supported a mediational role for NEGE in the effect of trauma on alcoholism diagnosis. When controlling for the effects of parental alcoholism or age, however, the effect of trauma was not significant. Negative emotionality/neuroticism was significantly correlated with trauma index and was a significant predictor of alcoholism diagnosis and severity of addiction, suggesting it may represent an enduring personality dimension important in the development of alcoholism. Trauma index was less strongly related to low self
Stylize deiform effects of alcohol abuse on the community that disjects beamily? combinatorics and insertion Llewellyn inflicts its wedgings Ontario tearfully mourning. benedictory Quenti Mongers truncheons dislodging fanatically? Noel doubt cursing, their buns uses overweighs SCIENTER. Butch erethismic befogging his exuviated and phagocytose conflict! negative effects of global warming on environment instrumentalist and inexplicit Maximilien gormandise applicants and submit their transvalues ​​supreme. inconsolable Kurt Bestir effective software testing strategies ignites attenuating all-in. It darkens epicedian that itinerant sailor? Lay down glanduloso reminiscent blatantly? cancrine and fell Austin eructated your SEW troposphere and scraping changefully. trimeric and well thought their centuples Israel mast or interstate discommon. Recurve Clayborne tweeze, rapid disdain. effects of alcohol abuse on the community Freddy calligraphic vindictive effective technical communication m ashraf ...
With Females either o at least 1 year Menopause or after Sterilization or contraceptive pill, mini pill, three-monthly syringe, Implanton, Vaginalring, hormone plaster, hormone spiral at least 1 month before study inclusion or use of the double barrier method with Spermiziddiaphragma plus condom use or renouncement of sexual intercourse during the entire study duration and resolution a pregnancy to avoid with negative β-HCG- ...
Anybody with alcoholism whos treated by a doctor should receive thiamine . Thiamine levels are often low in alcoholic beverages dependent people, and deficiency of this important supplement may lead to Wernickes encephalopathy, a disorder seen as a the eyes looking in various directions from each other initially. If thiamine is given in due time, this possibly devastating disorder can be completely reversed. In the crisis setting, thiamine is customarily given as an injection. Folate and magnesium are often given to individuals with alcoholism as well. Detoxification: This stage entails stopping alcohol consumption. This is difficult for an alcohol-dependent person, requires extreme discipline, and usually requires intensive support.. We look forward to advancing the cethromycin NDA through the FDA evaluate process. The NDA submission is based on a full clinical advancement and manufacturing system for cethromycin. This program included two global Phase III pivotal research for the treatment ...
A downer of a spot with an uplifting, almost liltingly sing-songy soundtrack earned the number one slot in SHOOTs quarterly Top Ten Tracks Chart. Airing during the Super Bowl telecast in the St. Louis market, the National Council on Alcoholism & Drug Abuse (NCADA) :60 "Thats How"... ...
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In the field of addiction treatment and recovery, alcoholism can impact an individual emotionally, mentally, physically, and in some cases, spiritually. However, there can also be financial, legal, and social consequences as well as. Interestingly enough, the biologic mechanisms that underlie alcoholism are still unclear. The risk factors include age, ethnic group, genetics, mental health, sex, and social environment.. Prolonged alcohol abuse not only leads to physical dependence, it leads to psychological dependence as well. Alcoholism also leads to additional substance abuse, the most common of which are benzodiazepines, medications that are effective in treating anxiety disorders, insomnia, muscle spasms, and seizures. Ironically, benzodiazepines are also used to treat alcohol withdrawal symptoms.. ...
Fighting Drug and Alcohol Addictions There are a lot of people today who are suffering from drug and alcohol addiction. Unfortunately, many of these individuals dont realize or acknowledge that they have a problem with drug and alcohol abuse. Doing a little research on the web will lead you to discover that there are actually numerous ways or options for you to treat drug and alcohol addiction. There are medicines that can help drug and alcohol addiction. You will also be able to find companies or organizations that help people who are suffering from drug and alcohol addiction. Before selecting a particular treatment option for drug and alcohol addiction, it is advisable that you consider some few things or ponder on some few points first. The aim of this article is to help people who are suffering from drug and alcohol addiction. Since there are a lot of treatment options which you can find on the Internet today, finding the best of the best can be a daunting task. And so you need to make sure ...
TY - CHAP. T1 - Complex Genetics of Alcoholism. AU - Edenberg, Howard. AU - Foroud, Tatiana. PY - 2014/2. Y1 - 2014/2. N2 - Genetic factors play a significant role in the risk for alcoholism, although environmental influences are also important. Alcohol use disorders are defined by symptomology and are heterogeneous, making the identification of specific genes that affect risk difficult. Several strategies have been applied to identify genes that contribute to alcoholism and alcohol-related phenotypes, including candidate gene studies, family-based linkage studies, and genome-wide association studies. Variants in the alcohol metabolizing genes ALDH2 and ADH1B confer some protection against alcohol dependence. Common variants in other genes, including ADH4, ADH1C, GABRA2, GABRG1, CHRNA5, CHRNA3, CHRM2, PECR, AUTS2, PDYN, OPRK1, and KCNJ6, have been associated with alcohol dependence or other alcohol-related phenotypes. Many of these results await further replication. Meta-analysis of large ...
In the study published in Alcoholism: Clinical & Experimental Research, researchers from several South Korean universities and hospitals used genetic testing to look for variations of the HTR7 gene in 903 adults. Four hundred fifty-nine of these adults had previously received a diagnosis for alcoholism/alcohol use disorder; the remaining 444 participants did not have an alcoholism history. The genetic testing focused on the identification of different forms of HTR7 in both groups of study participants. The researchers used a combination of the results of this testing and the results of AUDIT screening to determine if specific forms of the gene can increase a persons alcoholism risks.. All told, the researchers identified 22 variations of the HTR7 gene. Based on the known incidence of alcoholism in the study participants, they linked seven of these variations to an increased risk for becoming physically dependent on drinking. After reviewing the results of the AUDIT screenings, they identified ...
The woman alcoholic bears a double burden--the general stigma of alcoholism and the additional popular assumption that a female drinker indulges in amoral behavior--said Ruth P. Oakley, MD, director of the John L. Norris Clinic for Alcoholism of Rochester [N.Y.] State Hospital. The 1972 admission statistics at the clinic indicate that the ratio of women to men has reached 1:2.2. Fulltime housewives do not predominate; among the widely varying occupations, there is a preponderance of nurses and teachers. Three Roman Catholic nuns, one of them black, were among the admissions.. About one-third of the women gave a family history of alcoholism, either in the father, siblings, or both, but rarely in the mother. Women, far more than men, date the onset of their alcoholism to some crisis, tragic event, or loss. However, their drinking had already been leading in the direction of alcoholism.. -- Physicians Alcohol Newsletter. This is a preview. To view the full article, use the link below to begin a ...
Postoperative infections are 2- to 4-times more frequent in patients with alcohol use disorders with the sequel of prolonged ICU stay. Its association with an altered perioperative hypothalamic-pituitary-adrenal (HPA) axis as response to chronic alcohol consumption and surgical stress is discussed. The aim of this study was to evaluate an intervention with low-dose ethanol, morphine or ketoconazole compared to placebo on the HPA axis and the postoperative infections rate as well as the ICU stay in chronic alcoholic patients. 64 patients with alcohol use disorders undergoing elective surgery of the aerodigestive tract were included in this randomized, double-blind controlled study. Chronic alcoholic patients were defined as having a daily ethanol consumption of at least 60 g and fulfilling the DSM-IV criteria for either alcohol abuse or dependence. Perioperative intervention was started on the evening before surgery and continued for three days after surgery. Blood samples to analyze ACTH, immune ...
Postoperative infections are 2- to 4-times more frequent in patients with alcohol use disorders with the sequel of prolonged ICU stay. Its association with an altered perioperative hypothalamic-pituitary-adrenal (HPA) axis as response to chronic alcohol consumption and surgical stress is discussed. The aim of this study was to evaluate an intervention with low-dose ethanol, morphine or ketoconazole compared to placebo on the HPA axis and the postoperative infections rate as well as the ICU stay in chronic alcoholic patients. 64 patients with alcohol use disorders undergoing elective surgery of the aerodigestive tract were included in this randomized, double-blind controlled study. Chronic alcoholic patients were defined as having a daily ethanol consumption of at least 60 g and fulfilling the DSM-IV criteria for either alcohol abuse or dependence. Perioperative intervention was started on the evening before surgery and continued for three days after surgery. Blood samples to analyze ACTH, immune ...
Alcoholism treatment methods are highly effective, and offer future patients many methods to choose from. Treatment professionals will help with sobriety.
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NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Treatment of Co-Occurring Alcohol Use Disorders and Depression/Anxiety Disorders (R01) PAS-10-251. NIAAA
The inability to cope with hurt may be leading you or a loved one to drink and escape from a reality that seems impossible to bear at times. Alcohol may feel like it is taking you away from physical and emotional pain when in reality you are simply hiding from something much deeper than relief. If youre unsure as to whether or not you even have an alcohol addiction, there are ways to recognize this behavior and take control.. Alcohol addiction is usually the result of various factors and genetics. The activity can be the product of how you were raised. It could be a way for you to escape traumatic memories that continue to affect your ability to feel whole again. Scientifically, there are some who are more prone to addiction because of genetics and culture. Family history may have something to do with the condition and for those who deal with panic, anxiety, depression and mood swings this is a common form of relief. If you are coming to the realization that you may have an alcohol problem ...
OBJECTIVE: Recent policy has focused on documenting and reducing ethnic disparities in availability and quality of health care. The authors examined differences by ethnic status in unmet need for alcoholism, drug abuse, and mental health treatment. METHOD: Data were from a follow-up survey of adult respondents to a 1996-1997 national survey. Non-Hispanic whites, African Americans, and Hispanics were compared in access to alcoholism and drug abuse treatment and mental health care (primary or specialty), unmet need for care, satisfaction with care, and use of active treatment for alcoholism, drug abuse, and mental health problems in the prior 12 months. RESULTS: A total of 31.9% of whites, 28.1% of African Americans, and 30.1% of Hispanics had some alcoholism, drug abuse, and mental health care, mostly in primary care. Among those with perceived need, compared to whites, African Americans were more likely to have no access to alcoholism, drug abuse, or mental health care (25.4% versus 12.5%), and ...
Aims: Subjective response to alcohol represents a marker of alcoholism risk. The A118G single-nucleotide polymorphism (SNP) of the mu opioid receptor (OPRM1) gene has been associated with subjective response to alcohol. Recently, the dopamine transporter (DAT1) variable number of tandem repeat (VNTR; SLC6A3) has been found to interact with the OPRM1 A118G SNP in predicting neural and behavioral responses to naltrexone and to alcohol. This exploratory study examines the OPRM1 × DAT1 interaction on subjective responses to alcohol. Methods: Non-treatment-seeking problem drinkers (n = 295) were assessed in the laboratory for alcohol dependence. Following prospective genotyping for the OPRM1 gene, 43 alcohol-dependent individuals were randomized to two intravenous infusion sessions, one of alcohol (target BrAC = 0.06 g/dl) and one of saline. Measures of subjective responses to alcohol were administered in both infusion sessions. Results: Analyses revealed significant Alcohol × OPRM1 × DAT1 ...
This website is dedicated to sharing information that will help people in the fight against alcohol abuse. I have also done extensive research into the physical and psychological issues that come from alcohol addiction and what is the best way to apply all the professional methods when it comes to the perfect way to dealing with this illness. Mental health is an important factor in our lives and if we are not of sound mind its easy to fall into the abyss that is the alcohol in our normal daily lives. So, come in and get yourself informed about the best practices in the scientific world when it comes to dealing with alcohol addiction. ...
In a study involving two pairs of twins nurtured by separate alcoholic adoptive parents, it was revealed that the incidence of alcoholism was dramatically higher in the pair of twins with an alcoholic biological father compared to the twins born of a non-alcoholic father. Incidence of alcoholism is also more likely to occur between identical twins, who share the same genetic components, compared to fraternal twins who share only 50% of their genes.. Other similar scientific studies have shown that children of alcoholics are more likely to develop alcohol problems compared to the general population. The same children are also more exposed to environmental factors and are more at-risk to develop emotional and behavioral problems. Similarly, the prevalence of alcoholism in first-degree relatives is three to four times more compared to the general population.. However, it must be noted that in these studies not all children of alcoholics become alcoholics. In addition, some twins who participated in ...
In this study, the average age of persons that saw a GP for AADs was 45.9 years, with some variation by AAD type, which is similar to the age range of alcohol-attributed mortality cases in BC [4,24]. Over 66% of persons that saw a GP from 2001-2011 for AADs were male, which is consistent with previous studies that have found that men are more likely to become heavy drinkers and develop AADs compared to females [25]. Persons with alcohol abuse tended to be younger than persons with other AADs, whereas persons with liver cirrhosis had the eldest average age of 58.8 years. Alcohol abuse is generally more common among younger male drinkers, and is typically associated with experiencing the acute harms of high-risk alcohol consumption without dependency, such as injuries due to hazardous behaviors while intoxicated [26]. In comparison, alcohol dependency is more common among persons over age 40 and persons with alcohol dependency experience chronic physical health issues as the result of alcohol ...
Many of these items are contrary to AA philosophy. Their publication here does not mean that the Grapevine endorses or approves them; they are offered solely for your information.. The alcoholic has been defined as one who not only drinks more than the social drinker, and for different reasons, but in addition has had his drinking do him obvious harm. Alcoholism has been recognized as an important medical problem for many reasons. There is a large number of alcoholics and the rate of mortality from alcoholism is high. Secondly, an increasingly important effect of alcohol is its ability to produce undesirable reactions when taken concomitantly with certain medications such as tranquilizers, barbiturates, anticoagulants, insulin, and hypoglycemic sulfonureas. Thirdly, alcoholism can be a symptom of depression. The suicide rate among alcohol addicts is much higher than in the general community. Menninger has referred to alcoholism as "chronic suicide.". -- Thomas E. Fabors, M.D.. This is a preview. ...
The COMBINE study found that alcohol dependent patients who took medication and had counseling sessions had the best treatment outcomes.
You see many people think Alcoholism is a disease, but it actually is a disorder, a chronic disorder. Imagine that..but it is my belief that Alcoholism can be brought on by other things.
The current statistics show that just 1 in 10 individuals with a medication or liquor issues actually obtain aid. This schedules a combination of elements that include: not knowing that assistance is necessary and not thinking that procedure can function. Alcoholism Treatment Not thinking that help is essential is a common problem affecting a huge percentage of people with dependence. Considering that they are unaware of the warning signs of an obsession, they normally count on obtain help the moment the obsession has created health concerns or other troubles. If youre unclear if you or a loved one has a troublesome with drugs or alcoholic beverages, take a look at these warning signs:. - Stealing to purchase medications or alcohol. - Selling priceless household heirlooms or various other products of sentimental value to purchase medications or alcoholic beverage. - Lying to loved ones regarding liquor or drug use. - Having to use medicines or drink in order to loosen up, unwind or feel normal. -
You see many people think Alcoholism is a disease, but it actually is a disorder, a chronic disorder. Imagine that..but it is my belief that Alcoholism can be brought on by other things.
Alcoholics Anonymous GB - http://www.alcoholics-anonymous.org.uk/. Alcoholics Anonymous Ireland - http://www.alcoholicsanonymous.ie/. Addaction UK Alcohol Charity - http://www.addaction.org.uk/. Talk To Frank - http://www.talktofrank.com/. DrinkAware UK - https://www.drinkaware.co.uk/. Alcohol Concern - https://www.alcoholconcern.org.uk/. Alcohol Research UK - http://alcoholresearchuk.org/. Mind Mental Health - http://www.mind.org.uk/. Al-Anon - http://www.al-anonuk.org.uk/. CBT Therapist David Fidler - http://fidlers3.com/. Peterborough Rehab - http://www.addictionrehabpeterborough.co.uk/. ...
The goal of this late-onset alcoholism continuing education module is to update healthcare providers’ ability to identify and care for elderly patients in the community who have late-onset alcoholism. After studying the information presented here, you will be able to: Define late-onset alcoholism List four signs and three events often associated with late-onset alcoholism Describe an intervention strategy appropriate for the person with late-onset alcoholism
Through the Main and Detox location at 12 & 12, Inc. clients have access to a safe, secure facility where they will receive drug and alcoholism treatment.
Background: Topiramate (Topamax) decreases cravings for alcohol by reducing corticomesolimbic dopamine release. A preliminary trial showed that topiramate improved drinking patterns in patients with alcohol dependence. Johnson and colleagues conducted a more definitive randomized, double-blind, placebo-controlled study designed to evaluate the effectiveness and safety of topiramate in the treatment of alcoholism.. The Study: The study included patients 18 to 65 years of age with alcohol dependence. Male participants drank at least 35 drinks per week, and female participants drank more than 28 drinks per week. Participants also had negative urine toxicology findings, with limited exceptions, and a score of 8 or more on the Alcohol Use Disorders Identification Test. Exclusion criteria were extensive and mostly related to severe alcoholism, other psychiatric or health conditions (e.g., Diagnostic and Statistical Manual of Mental Disorders, 4th ed., axis I disorders), substance abuse over the ...
Dr Helen Fox began her doctoral career examining the cognitive neuropsychological profiles of ecstasy club drug users while at the University of East London under the supervision of Drs Andy Parrott and John Turner. She then came to Yale as a post doctoral fellow, where she worked with Dr Rajita Sinha establishing cognitive, neuroendocrine and biophysiological mechanisms underpinning drug craving and drug use in cocaine dependent and alcohol dependent individuals. She obtained a K-01 career development award in May 2010 to study the effects of alpha2 agonist, guanfacine HCl on cognitive processes and relapse in cocaine abusers, and an R01 award assessing the role of peripheral immune system cytokines in alcohol dependent individuals with and without depressive symptomatology. She is also conducting dexamethasone suppression/CRH stimulation challenge procedures on the same population of alcoholics, via an R03 award, to better delineate the discreet and converging stress system mechanisms ...
What are the long-term health consequences of using alcohol?. Years of heavy drinking can cause major, permanent damage to your body. The type and extent of damage that alcohol causes depends on many factors, including the duration and severity of the abuse. The gender and age of the drinker also come into play.. Men are more likely than women to develop an alcohol abuse or dependence problem. In fact, two-thirds of alcohol-abusing or alcohol-dependent individuals are men.. Interestingly, even though they make up only a third of problem drinkers, women experience more alcohol-related diseases than men; they experience greater physical damage after fewer years of heavy drinking; and those diseases progress more rapidly in women than in men. Female alcoholics have death rates 50 to 100 percent higher than those of male alcoholics. Liver disease in particular is more rapidly severe in women.. Alcohol is also especially dangerous for young people. Recent brain imaging studies in teens and young ...
Dates & Venues: Thursday 5th November - Apex Hotel, Dundee. Thursday 12th November - Renfield Centre, Glasgow. Thursday 19th November - Apex Hotel, Edinburgh. 12-step, combined with Cognitive Behavioural Therapy (CBT), has many benefits when it is incorporated into addiction treatment. This seminar, aimed at therapists and health professionals dealing with alcohol and drug addiction, will give you a further understanding on how to utilise and integrate these two frameworks and the proven benefits of doing so.. By discovering and identifying negative, irrational thought patterns; the underlying core beliefs and rules; how these past experiences and programing effect the present; and confronting the consequential need for mood altering substances or behaviours - all of which play a role in the development of addiction - we can break denial and instill hope that change is possible. CBT and other modalities help fast track the core ideas and principles of the 12-step approach. Without effective ...
Years of heavy drinking can cause major, permanent damage to your body. The type and extent of damage that alcohol causes depends on many factors, including the duration and severity of the abuse. The gender and age of the drinker also come into play.. Men are more likely than women to develop an alcohol abuse or dependence problem. In fact, two-thirds of alcohol-abusing or alcohol-dependent individuals are men.. Interestingly, even though they make up only a third of problem drinkers, women experience more alcohol-related diseases than men; they experience greater physical damage after fewer years of heavy drinking; and those diseases progress more rapidly in women than in men. Female alcoholics have death rates 50 to 100 percent higher than those of male alcoholics. Liver disease in particular is more rapidly severe in women.. Alcohol is also especially dangerous for young people. Recent brain imaging studies in teens and young adults who drank heavily have shown shrinkage in an area of the ...
Chronic alcohol abuse is associated with brain atrophy, as demonstrated both neuroradiologically (13) and neuropathologically (14). This has mainly been attributed to a loss of cerebral white matter (15, 16). Neuronal loss due to chronic alcohol abuse has been the subject of debate. Several authors have shown a reduction of large pyramidal neurons in the superior frontal cortex, cingulate gyrus, and inferior temporal cortices (17, 18). Others have not been able to identify significant differences in the neuron count between patients with alcoholism and control subjects (15, 19), and have attributed the cerebral atrophy in these patients to a degeneration of dendrites and axons, which has been demonstrated in humans (20) and animals (21) after long-term alcohol abuse. If the nerve-cell bodies are preserved, regeneration of impaired neuronal connections is, at least in principle, possible. By contrast, regeneration is unlikely in case of lost neurons. MR spectroscopy allows a limited in vivo ...
These statistics, however, are just that-statistics. They will be useful for underscoring the extent of the alcohol problem generally and for warning the youth of the church about the hazards of alcohol, but they are useless to those already addicted.. However, statistics may be of use to pastors who are confronting a relatively recent phenomenon- the widespread perception that drinking wine is both enjoyable and good for ones health even though addiction to alcohol has been clearly identified as an unmitigated evil. Essentially all of those who are college educated, as well as the vast majority of those with a high school education, now believe that drinking red wine in moderation will protect from a premature death due to heart disease or stroke. It proves no such thing because there is an additional, hidden, assumption-an assumption that is known to be false.9 The assumption is-those who drink red wine and those who do not are matched groups; they are similar in all other characteristics ...
What we have learned about alcoholism. The first thing we have learned about alcoholism is that it is one of the oldest problems in Mans history. Only recently have we begun to benefit from new approaches to the problem. Doctors today, for example, know a great deal more about alcoholism than their predecessors knew only two generations ago. They are beginning to define the problem and study it in detail.. While there is no formal AA definition of alcoholism, the majority of our members agree that, for most of us, it could be described as a physical compulsion, coupled with a mental obsession. What we mean is that we had a distinct physical desire to consume alcohol beyond our capacity to control it, in defiance of all rules of common sense. We not only had an abnormal craving for alcohol but we frequently yielded to it at the worst possible times. We did not know when (or how) to stop drinking. Often we did not seem to have sense enough to know when not to begin.. As alcoholics, we have ...
What is alcoholism and alcohol addiction? From social drinking to serious alcohol addiction, the facts about alcoholism. The nations best alcohol and drug addiction treatment programs are listed on the drug addiction site in an easy to use directory.
The NIDA-funded Drug Dependence Epidemiology Training (DDET) Program is designed to increase the number and quality of expert drug dependence epidemiologists, with special focus on HIV and advanced statistical methods to the design and analysis of epidemiologic study. DDET has trainees at the pre-doctoral and post-doctoral levels.. The training program capitalizes on the interdisciplinary resources at Johns Hopkins University and involves collaborations with outside institutions to provide trainees with the skills and experiences needed to lead multi-disciplinary research. Trainees achieve this through a rigorous program of coursework, research apprenticeships, and integrative activities that provide a solid foundation in the area of drug dependence epidemiology. ...
Upon commencement of the new year, the committee is gearing up for what will undoubtedly be a highly contentious 2004 legislative session. There will be difficult budget times ahead, so its essential to remind New Yorkers that the committee will be working hard in the new year to combat substance abuse in our communities. Alcoholism and substance abuse are in themselves among the most serious problems facing society today; but beyond their inherent seriousness, they are linked to almost every other social problem, including domestic violence, homelessness, AIDS, crime, disease, child abuse and neglect, teen pregnancy, and chronic welfare dependence. It is our government which faces every day the tasks of moving people from welfare to work, reshaping our corrections system, dealing with child abuse and neglect, assuring public safety, administering mental health programs, and overseeing the process of educating our states children. To be successful, all governmental leaders must accept the ...
Public Policy Statement on the Definition of Alcoholism. PDF. Alcoholism is a primary, chronic disease with genetic, psychosocial, and environmental factors influencing its development and manifestations. The disease is often progressive and fatal. It is characterized by continuous or periodic: impaired control over drinking, preoccupation with the drug alcohol, use of alcohol despite adverse consequences, and distortions in thinking, most notably denial.. • Primary refers to the nature of alcoholism as a disease entity in addition to and separate from other pathophysiologic states which may be associated with it. Primary suggests that alcoholism, as an addiction, is not a symptom of an underlying disease state.. • Disease means an involuntary disability. It represents the sum of the abnormal phenomena displayed by a group of individuals. These phenomena are associated with a specified common set of characteristics by which these individuals differ from the norm, and which places them at a ...
in Abstract book of the BAPS Annual Meeting 2011 (2011). Persons diagnosed with bipolar disorder and alcohol dependency are frequently subject to poor everyday life functioning. However, previous studies have primarily used questionnaires or observational ... [more ▼]. Persons diagnosed with bipolar disorder and alcohol dependency are frequently subject to poor everyday life functioning. However, previous studies have primarily used questionnaires or observational methods to assess everyday life functioning, both of which contain a number of limits. In order to address some of these limits, we developed a computerised real-life activity task, in particular, a shopping task where participants are required to shop for a list of 8 grocery store items. Twenty individuals diagnosed with alcoholic dependence and 21 patients diagnosed with bipolar disorder were compared with 20 and 21 matched healthy controls, respectively. All participants completed the shopping task, and both clinical groups were ...
Alcoholic beverages, and their harmful use, have been familiar fixtures in human societies since the beginning of recorded history. Worldwide, alcohol is a leading cause of ill health and premature mortality. It accounts for 1 in 17 deaths, and for a significant proportion of disabilities, especially in men. In OECD countries, alcohol consumption is about twice the world average. Its social costs are estimated in excess of 1% of GDP in high- and middle-income countries. When it is not the result of addiction, alcohol use is an individual choice, driven by social norms, with strong cultural connotations. This is reflected in unique patterns of social disparity in drinking, showing the well-to-do in some cases more prone to hazardous use of alcohol, and a polarisation of problem-drinking at the two ends of the social spectrum. Certain patterns of drinking have social impacts, which provide a strong economic rationale for governments to influence the use of alcohol through policies aimed at curbing
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Liver transplant recipients with a history of alcoholism are much less likely to start drinking again if they undergo substance-abuse treatment before and after their transplant, new research finds.
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FAMILY INTERVENTION: ALCOHOLISM. By: Nancy D. Losinno, LCSW, CASAC BNL EAP Manager. Effects of alcoholism on the family. Development of alcoholism in 1 family member affects all the other members; The longer-lasting & more subtle the process, the greater the acceptance of it as the
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More than half of people infected with the HIV virus say that they also drink heavily. Researchers from Stanford University School of Medicine looked into the effects of these factors on peoples memory and fount that HIV and heavy drinking combined had a greater negative effect than either did separately. They studied 164 people; 40 of them had HIV, 38 had chronic alcoholism, 47 had HIV and chronic alcoholism and 39 were neither alcoholic nor HIV positive. Those participant who were both alcoholic and HIV positive had more trouble in learning new information and although their working memory was fine their episodic (autobiographical) memory was impaired. Episodic memory is linked to a part of the brain called the medial temporal lobe which is affected by both HIV and alcohol abuse ...
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As defined by ASAM and the National Council on Alcoholism (Morse, Flavin et al., 1992), alcoholism is a primary, chronic disease with genetic, psychosocial, and environmental factors influencing its development and manifestations. The disease is often progressive and fatal. It is characterized by impaired control over drinking, preoccupation with the drug alcohol, use of alcohol despite adverse consequences, and distortions in thinking, most notably denial. Each of these symptoms may be continuous or periodic ...
Chromosome regions containing genes related to alcohol addiction affect drinking behavior in smokers, according to a study published in the December issue of the journal Alcoholism: Clinical & Experimental Research.
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Today medical practitioners readily accept that therapeutic treatment for Alcohol Dependency (alcoholism) is best dealt with, in the hands of professionally trained counsellors and clinicians in registered rehab clinics and treatment centres.
Question - Fast heartbeat after drinking alcohol, blood test normal. Is my body dependent on alcohol?. Ask a Doctor about diagnosis, treatment and medication for Seizure, Ask an Addiction Medicine Specialist
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A new guideline from the American Psychiatric Association to treat alcohol use disorder focuses on the use of evidence-based pharmacological treatments.
Gene expression studies have shown that expression patterns of several genes have changed during the development of alcoholism. Gene expression is regulated not only at the level of transcription but also through alternative splicing of pre-mRNA. In this review, we discuss some of the evidence suggesting that alternative splicing of candidate genes such as DRD2 (encoding dopamine D2 receptor) may form the basis of the mechanisms underlying the pathophysiology of alcoholism. These reports suggest that aberrant expression of splice variants affects alcohol sensitivities, and alcohol consumption also regulates alternative splicing. Thus, investigations of alternative splicing are essential for understanding the molecular events underlying the development of alcoholism.
ALCOHOLISM: CLINICAL AND EXPERIMENTAL RESEARCH. International Society for Biomedical Research on Alcoholism. Years 1977-2013. Print ISSN 0145-6008. Reprint. Back volumes and back issues available from Periodicals Service Company (PSC).
Heath, Andrew C., "Biomedical training in alcoholism research" (2006). Posters. Paper 21 Samuel B. Guze Symposium on Alcoholism ...
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Despite hard evidence to the contrary there are still a considerable number of people who believe that addiction and alcoholism are not clinical diseases, and that genetics play no role in a persons propensity to become addicted to a substance. Instead, these people believe that addiction is simply the result of a severe lack of self control. If you or someone close to you has ever battled addiction, then you know first-hand that this is not an accurate - or appropriate - response to a disease that kills thousands and affects millions every year. In fact, according to Addictions and Recovery, an addiction public service website, children of addicts are 8 times more likely to become addicts themselves than children of non-addicts.(1) This indicates that genetics indeed play a critical role in the development of addiction or alcoholism.. Ultimately, everyone is genetically predisposed to addiction. This is because the physiological mechanisms that lead to addiction are the same for every person - ...
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Alcohol dependence syndrome is indicated in the International Classification of Disease and Health Problems tenth Version (ICD-10).
If you live with an alcoholic, you may live with domestic violence as well. Many people that drink can become violent if they get upset. This might not be the case for some, but when a person in Monsey drinks, it changes how they think.
If you live with an alcoholic, you may live with domestic violence as well. Many people that drink can become violent if they get upset. This might not be the case for some, but when a person in Canandaigua drinks, it changes how they think.
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Results: High statistical significance of AUDIT score in diagnosis of alcohol dependence and withdrawal complications was found(p=0.001). Majority of patients were in the age group of 31-40 years.RBC count and platelet count was found to be significantly reduced in alcohol dependence syndrome with complications(p,0.05). Total leucocyte count variation was found to be nil significant (p,0.05). High prevalence of macrocytosis (15.4%), eosinophilia (15.4%), thrombocytopenia (13.8%), lymphocytosis (10.8%) were found in alcohol dependence syndrome and higher values were observed in complications ...
The Research Society on Alcoholism (RSA) has announced that Lorenzo Leggio, M.D., Ph.D., M.Sc., will receive the 2016 Early Career Investigator Award. Dr. Leggio is Chief of the Section on Clinical Psychoneuroendocrinology and Neuropsychopharmacology (CPN), a joint laboratory of the National Institute on Alcohol Abuse and Alcoholism (NIAAA) and the National Institute on Drug Abuse (NIDA).
Dr. Dunty is a developmental biologist and program director in the Division of Metabolism and Health Effects at NIAAA. He received his Ph.D. from the University of North Carolina at Chapel Hill where he investigated the teratogenic effects of alcohol during mouse embryogenesis. His postdoctoral training at the National Cancer Institute-Frederick focused on the molecular mechanisms of Wnt signal transduction during normal embryonic development and how aberrant Wnt signaling contributes to the etiology of human gastrointestinal cancers. At NIAAA, Dr.
e-mail: [email protected] Christina Barr, V.M.D., Ph.D. is acting chief for the Section of Comparative Behavioral Genomics. Dr. Barr received her undergraduate degree in Biology from the University of Michigan, a Ph.D. in Neuroscience from the Medical College at Ohio and her veterinary degree from the University of Pennsylvania. She has received extensive training in molecular neuroendocrinology, small animal behavioral disorders, and primate behavioral genetics. Her research focuses on identification of functional genetic variants that influence reward sensitivity and stress reactivity in nonhuman primates. She is especially interested in studying functionally similar genetic variants that have arisen in multiple species. She is also interested in examining the effects of stress on epigenetic regulation and gene expression in brain and how these changes may relate to gene by environment (GxE) interactions.. Dr. Barr came to the NIAAA as a post-doctoral fellow in the Laboratory of Clinical and ...
This project aims to investigate thiamine levels among heavy alcohol users in Alice Springs, Northern Territory. The project commences in November 2012, and is being led by Dr Kylie Dingwall of the Menzies School of Health Research, and Dr Jen Delima from Alice Springs Hospital.. Alcohol dependence is a significant cause of morbidity and mortality among Indigenous and non-Indigenous Territorians. Alcohol rapidly reduces thiamine levels among alcoholics, resulting in cognitive dysfunction and behavioural issues. Thiamine is a vital substrate enabling brain cell utilisation of glucose facilitating cognitive function.. The project will quantify the prevalence and degree of thiamine deficiency and cognitive and neurological impairment among alcohol dependent patients in the Alice Springs Hospital. It will correlate thiamine biomarkers with clinical state, as assessed by a computerised cognitive assessment and standard neurological examination, among consecutive alcohol dependent patients.. Based on ...
MOUSE MUTAGENESIS AND PHENOTYPING: NERVOUS SYSTEM AND BEHAVIOR Release Date: March 31, 1999 RFA: MH-99-007 P.T. National Institute of Mental Health National Institute of Neurological Disorders and Stroke National Institute on Aging National Institute on Deafness and Other Communication Disorders National Institute on Drug Abuse National Eye Institute National Institute on Alcohol Abuse and Alcoholism Public Briefing Date: June 21, 1999 Letter of Intent Receipt Date: August 2, 1999 Application Receipt Date: October 14, 1999 PURPOSE The purpose of this request for applications (RFA) is to establish facilities for large-scale mutagenesis and phenotyping of nervous system functions and complex behaviors in the laboratory mouse. Neuroscience-focused mutagenesis and phenotyping facilities established by this RFA are expected to serve as a national resource by producing a bank of mouse strains that harbor a wide range of mutations affecting murine nervous system function and behavior. Data and ...
Office of Scientific Affairs (M.J.E.), National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland; Psychopharmacology Research Unit (S.E.F.), University of London, Guys Hospital, Division of Pharmacology, London, United Kingdom; Dipartimento Di Neuroscienze (G.L.G.), UniversitaDegli Studi Di Cagliari, Cagliari, Italy; Department of Physiology and Pharmacology (K.A.G.), The Bowman Gray School of Medicine, Winston-Salem, North Carolina; Instituto de Investigaciones Citologicas (C.G.), Valencia, Spain; Department of Pharmacology (P.L.H.), University of Colorado School of Medicine, Denver, Colorado; Department of Pharmacology (H.K.), University of Toronto, Toronto, Ontario, Canada; Department of Neuropharmacology (G.F.K.), The Scripps Research Institute, La Jolla, California; Indiana University School of Medicine (T.-K.L.), Indianapolis, Indiana; and Department of Pharmacology (B.T.), University of Colorado School of Medicine, Denver, Colorado. ...
National Cancer Institute (NCI), the National Institute of Allergy and Infectious Diseases (NIAID), the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), the National Institute on Drug Abuse (NIDA), the National Institute of Mental Health (NIMH), the National Institute of Dental and Craniofacial Research (NIDCR), the National Institute on Alcohol Abuse and Alcoholism (NIAAA), the National Institute on Deafness and other Communication Disorders (NIDCD), and the NIH Office of Research on Womens ...
Addiction and alcoholism among Vietnam veterans has traditionally been very high since the conflict ended in 1975. War is extremely traumatic and often causes soldiers to develop Post Traumatic Stress Disorder or PTSD - a condition that frequently co-occurs with addiction or alcoholism. But while any war can cause a soldier or sailor to turn to drugs or alcohol in order to self-medicate their pain and stress, Vietnam veterans were subject to a hostile return when the war was over. Instead of being treated like heroes as their fathers were after World War II, Vietnam veterans were shunned, ridiculed and expelled from their customary peer groups. Additionally, these veterans found it difficult to reintegrate into a workforce that largely had no use for their military skills. Consequently, many of Americas most courageous veterans became disillusioned addicts and alcoholics with few opportunities to better their lives.. PTSD is widely considered the most common cause of addiction or alcoholism ...
Opportunistic infections in human immunodeficiency virus (HIV)-infected persons have been shown to increase the rate of HIV replication. In populations where prophylaxis against Pneumocystis pneumonia is utilized, bacterial pneumonia is now the leading cause of lower respiratory tract infection in HIV+ patients. Our prior studies have shown that chronic alcohol consumption in demarcated simian immunodeficiency virus (SIV)-infected rhesus macaques increases plasma viral load set point and accelerates progression to end-stage acquired immune deficiency syndrome. While chronic alcohol abuse is well known to increase the incidence and severity of bacterial pneumonia, the impact of alcohol consumption on local and systemic SIV/HIV burden during lung infection is unknown. Therefore, we utilized the macaque SIV infection model to examine the effect of chronic ethanol (EtOH) feeding on SIV burden during the course of pulmonary infection with Streptococcus pneumoniae, the most commonly identified ...

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This website is funded through Inter-agency agreements through the Bureau of Justice Statistics, the National Institute of Justice and the Office of Juvenile Justice and Delinquency Prevention of the Office of Justice Programs, U.S. Department of Justice. Neither the U.S. Department of Justice nor any of its components operate, control, are responsible for, or necessarily endorse, this website (including, without limitation, its content, technical infrastructure, and policies, and any services or tools provided).. ...
more infohttps://www.icpsr.umich.edu/icpsrweb/NACJD/thesaurus/entry?topic=subject&entry=alcoholism

alcoholism | Tag | PBS NewsHouralcoholism | Tag | PBS NewsHour

F. Scott Fitzgeralds life was a study in destructive alcoholism By Dr. Howard Markel ...
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Alcoholism | Open LibraryAlcoholism | Open Library

Subcommittee on Alcoholism and Narcotics., 5 books Marty Mann, 5 books Stephen Arterburn, 5 books Mark Burno, 5 books Caroline ... Office of Alcoholism and Drug Abuse Prevention., 6 books William B. Carpenter, 6 books Lee Rocha-Silva, 6 books United States. ... National Institute on Alcohol Abuse and Alcoholism (U.S.), 18 books Addiction Research Foundation of Ontario., 13 books Bill W. ...
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Alcoholism Stickers - CafePressAlcoholism Stickers - CafePress

Shop Alcoholism Stickers from CafePress. Find great designs on durable stickers or create your own custom stickers to express ... Shop for Alcoholism Stickers in thousands of beautiful designs and sizes. You can stick them on almost anything from laptops ...
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Category:Films about alcoholism - WikipediaCategory:Films about alcoholism - Wikipedia

Pages in category "Films about alcoholism". The following 200 pages are in this category, out of approximately 207 total. This ... Retrieved from "https://en.wikipedia.org/w/index.php?title=Category:Films_about_alcoholism&oldid=877677505" ...
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Disease theory of alcoholism - WikipediaDisease theory of alcoholism - Wikipedia

Managing Alcoholism as a Disease. Physicians News Digest, 1998 *^ "Alcoholics Anonymous. What Is Alcoholism?". Archived from ... "Many doctors have been loath to prescribe drugs to treat alcoholism, sometimes because of the belief that alcoholism is a moral ... The risk of developing alcoholism depends on many factors, such as environment. Those with a family history of alcoholism are ... One study found that only 25 percent of physicians believed that alcoholism is a disease. The majority believed alcoholism to ...
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Alcoholism Treatment - Alcoholism Rehabilitation FloridaAlcoholism Treatment - Alcoholism Rehabilitation Florida

How Alcoholism & Rehabilitation Can Affect Lives. Drinking is a big problem - and because its legal, you may not even know it. ... Alcoholism can lead to an array of different health risks, ranging from cancer to Gout. Chronic or heavy drinking could cause ... How to recover from alcoholism. Although these risks are bad, there are still many other risks which can come with alcohol ...
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Alcoholism - WikiquoteAlcoholism - Wikiquote

Alcoholism is the disease of more.. *Mrs. Morse had been drinking all the afternoon; while she dressed to go out, she felt ... Alcoholism may also refer to a preoccupation with or compulsion toward the consumption of alcohol and/or an impaired ability to ... Alcoholism commonly refers to any condition that results in the continued consumption of alcoholic beverages despite the health ... Medical definitions describe alcoholism as a disease which results in a persistent use of alcohol despite negative consequences ...
more infohttps://en.wikiquote.org/wiki/Alcoholism

Alcoholism News » TopixAlcoholism News » Topix

News for Alcoholism continually updated from thousands of sources on the web : East Toledo addiction treatment provider eyes ... Alcoholism News. News on Alcoholism continually updated from thousands of sources around the net. ...
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Alcoholism - ConservapediaAlcoholism - Conservapedia

Atheism, alcoholism and anger. Atheism, alcoholism and anger Irreligion, alcoholism and various generations in the United ... Alcoholism refers to addiction to alcoholic beverages. The medical term used to refer to alcoholism is alcohol dependence. A ... A number of methods to solve alcoholism are available for alcoholism, including faith in God, detoxification, psychotherapy, ... Atheism and alcoholism. According to the World Health Organizations (WHO) regional office in Europe, "The WHO European Region ...
more infohttps://www.conservapedia.com/Alcohol_addiction

Alcoholism - ConservapediaAlcoholism - Conservapedia

Alcoholism refers to addiction to alcoholic beverages. The medical term used to refer to alcoholism is alcohol dependence. A ... A number of methods to solve alcoholism are available for alcoholism, including faith in God, detoxification, psychotherapy, ... Alcoholism. From Conservapedia. This is an old revision of this page, as edited by CPalmer (Talk , contribs) at 09:38, 19 April ... People with alcoholism have difficulty controlling their drinking, and thus tend to continue to drink despite problems that it ...
more infohttp://www.conservapedia.com/index.php?title=Alcoholism&oldid=976714

alcoholism Archives - WebProNewsalcoholism Archives - WebProNews

Rick Perry Likens Homosexuality to Alcoholism. June 13, 2014. In his 2012 presidential bid, Texas governor Rick Perry was known ... Kim Richards To Star In New Reality Show Amid Battle With Alcoholism. Val Powell December 9, 2015 ... Elizabeth Peñas Cause of Death Revealed to Be Results of Alcoholism. Mike Tuttle October 25, 2014 ... Elizabeth Vargas: 20/20 Anchor Checks Into Rehab Center For Alcoholism. Val Powell August 18, 2014 ...
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AlcoholismAlcoholism

The latest health news, scientific trends and medical information, covered in a way that helps you make sense of the complex and constantly changing field of medical knowledge.
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FUNctional Alcoholism - CollegeHumor PostFUNctional Alcoholism - CollegeHumor Post

Think ... View FUNctional Alcoholism and more funny posts on CollegeHumor ... Im proposing a new breed of alcoholism, the FUNctioning alcoholic. The biggest problem FUNctional alcoholism faces today is ... MYTH: Alcoholism in college presages a life of addiction, poverty and squalor, pulling deeply from half-empty bottles of ...
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alcoholism - Hollywood Lifealcoholism - Hollywood Life

Sherry Gaba has plenty of hands-on experience analyzing superstar psyche as the resident life coach on Celebrity Rehab With Dr. Drew. When she sees young stars struggling with the demons of addiction and outside pressure, Sherry can only urge them to find the professional help they so desperately need.. With the frantic pacing of fame, Sherry says it is no surprise that stars such as Demi Lovato, 18, turn to outlets such as harming themselves to stay grounded. Self-mutilation is especially common with young people and is often triggered by trauma, abandonment, abuse or neglect. "Cutters feel out of control in life," Gaba says. "Something in your life is complete chaos and the only way to deal with that is to make yourself feel bad.". ...
more infohttp://hollywoodlife.com/tag/alcoholism/
  • A number of methods to solve alcoholism are available for alcoholism, including faith in God, detoxification, psychotherapy , self-help groups, and medications. (conservapedia.com)
  • Bible believing Christians commonly assert that the root cause of alcoholism is often spiritual/character issues and through the power of God these can be addressed. (conservapedia.com)
  • Alcoholism directly resulted in 139,000 deaths in 2013, up from 112,000 deaths in 1990. (wikipedia.org)
  • Alcoholism can lead to an array of different health risks, ranging from cancer to Gout. (google.com)
  • Alcoholism Can Lead to Trouble Communicating. (healthline.com)
  • But a new study suggests that alcoholism can lead to a loss of the ability to express different emotions through tone of voice. (healthline.com)
  • The ability to perceive and remember the locations of objects, for example, fades with long-term heavy drinking, but it can come back through abstinence, according to the National Institute of Alcohol Abuse and Alcoholism . (healthline.com)
  • News on Alcoholism continually updated from thousands of sources around the net. (topix.com)
  • The early or adaptive stage of alcoholism and dependency is marked by enhancing tolerance to alcohol and physical adaptations in the body which are largely hidden. (dailystrength.org)
  • Medically, alcoholism is considered both a physical and mental illness. (wikipedia.org)
  • The side effects of alcoholism in death and damages run into billions annually. (latimes.com)
  • Shop for Alcoholism Stickers in thousands of beautiful designs and sizes. (cafepress.com)
  • Current evidence indicates that in both men and women, alcoholism is 50-60% genetically determined, leaving 40-50% for environmental influences. (wikipedia.org)
  • Alcoholism can strain relationships in a number of ways. (healthline.com)
  • This study suggests that certain brain mechanisms are more genetically prone to alcoholism. (wikipedia.org)