Alcohol Dehydrogenase
Alcohol Oxidoreductases
A subclass of enzymes which includes all dehydrogenases acting on primary and secondary alcohols as well as hemiacetals. They are further classified according to the acceptor which can be NAD+ or NADP+ (subclass 1.1.1), cytochrome (1.1.2), oxygen (1.1.3), quinone (1.1.5), or another acceptor (1.1.99).
Alcohol Drinking
Alcohols
Ethanol
A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant. It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as the primary ingredient in ALCOHOLIC BEVERAGES.
L-Lactate Dehydrogenase
Aldehyde Dehydrogenase
NAD
A coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)
L-Iditol 2-Dehydrogenase
Acetaldehyde
Horses
Glyceraldehyde-3-Phosphate Dehydrogenases
Sugar Alcohol Dehydrogenases
Malate Dehydrogenase
Glutamate Dehydrogenase
Isocitrate Dehydrogenase
An enzyme of the oxidoreductase class that catalyzes the conversion of isocitrate and NAD+ to yield 2-ketoglutarate, carbon dioxide, and NADH. It occurs in cell mitochondria. The enzyme requires Mg2+, Mn2+; it is activated by ADP, citrate, and Ca2+, and inhibited by NADH, NADPH, and ATP. The reaction is the key rate-limiting step of the citric acid (tricarboxylic) cycle. (From Dorland, 27th ed) (The NADP+ enzyme is EC 1.1.1.42.) EC 1.1.1.41.
Benzyl Alcohols
Liver
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Alcoholism
A primary, chronic disease with genetic, psychosocial, and environmental factors influencing its development and manifestations. The disease is often progressive and fatal. It is characterized by impaired control over drinking, preoccupation with the drug alcohol, use of alcohol despite adverse consequences, and distortions in thinking, most notably denial. Each of these symptoms may be continuous or periodic. (Morse & Flavin for the Joint Commission of the National Council on Alcoholism and Drug Dependence and the American Society of Addiction Medicine to Study the Definition and Criteria for the Diagnosis of Alcoholism: in JAMA 1992;268:1012-4)
Carbohydrate Dehydrogenases
Amino Acid Sequence
Isoenzymes
Benzyl Alcohol
Substrate Specificity
Glucose 1-Dehydrogenase
Dihydrolipoamide Dehydrogenase
Succinate Dehydrogenase
NADP
Nicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
Coenzymes
Oxidation-Reduction
A chemical reaction in which an electron is transferred from one molecule to another. The electron-donating molecule is the reducing agent or reductant; the electron-accepting molecule is the oxidizing agent or oxidant. Reducing and oxidizing agents function as conjugate reductant-oxidant pairs or redox pairs (Lehninger, Principles of Biochemistry, 1982, p471).
1-Propanol
Hydroxysteroid Dehydrogenases
Glucose Dehydrogenases
Base Sequence
Oxidoreductases
The class of all enzymes catalyzing oxidoreduction reactions. The substrate that is oxidized is regarded as a hydrogen donor. The systematic name is based on donor:acceptor oxidoreductase. The recommended name will be dehydrogenase, wherever this is possible; as an alternative, reductase can be used. Oxidase is only used in cases where O2 is the acceptor. (Enzyme Nomenclature, 1992, p9)
Cloning, Molecular
Mannitol Dehydrogenases
3-Hydroxyacyl CoA Dehydrogenases
17-Hydroxysteroid Dehydrogenases
Methanol
Phosphogluconate Dehydrogenase
Acetobacter
NADH Dehydrogenase
A flavoprotein and iron sulfur-containing oxidoreductase that catalyzes the oxidation of NADH to NAD. In eukaryotes the enzyme can be found as a component of mitochondrial electron transport complex I. Under experimental conditions the enzyme can use CYTOCHROME C GROUP as the reducing cofactor. The enzyme was formerly listed as EC 1.6.2.1.
IMP Dehydrogenase
Hydrogen-Ion Concentration
PQQ Cofactor
Alcoholic Intoxication
Binding Sites
Formate Dehydrogenases
Flavoproteins that catalyze reversibly the reduction of carbon dioxide to formate. Many compounds can act as acceptors, but the only physiologically active acceptor is NAD. The enzymes are active in the fermentation of sugars and other compounds to carbon dioxide and are the key enzymes in obtaining energy when bacteria are grown on formate as the main carbon source. They have been purified from bovine blood. EC 1.2.1.2.
Central Nervous System Depressants
Acyl-CoA Dehydrogenase
Xanthine Dehydrogenase
Zinc
A metallic element of atomic number 30 and atomic weight 65.38. It is a necessary trace element in the diet, forming an essential part of many enzymes, and playing an important role in protein synthesis and in cell division. Zinc deficiency is associated with ANEMIA, short stature, HYPOGONADISM, impaired WOUND HEALING, and geophagia. It is known by the symbol Zn.
Sequence Homology, Amino Acid
Pyruvate Decarboxylase
Gram-Positive Asporogenous Rods, Irregular
3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide)
A ketone oxidoreductase that catalyzes the overall conversion of alpha-keto acids to ACYL-CoA and CO2. The enzyme requires THIAMINE DIPHOSPHATE as a cofactor. Defects in genes that code for subunits of the enzyme are a cause of MAPLE SYRUP URINE DISEASE. The enzyme was formerly classified as EC 1.2.4.3.
Retinal Dehydrogenase
Fermentation
Fetal Alcohol Spectrum Disorders
An umbrella term used to describe a pattern of disabilities and abnormalities that result from fetal exposure to ETHANOL during pregnancy. It encompasses a phenotypic range that can vary greatly between individuals, but reliably includes one or more of the following: characteristic facial dysmorphism, FETAL GROWTH RETARDATION, central nervous system abnormalities, cognitive and/or behavioral dysfunction, BIRTH DEFECTS. The level of maternal alcohol consumption does not necessarily correlate directly with disease severity.
Escherichia coli
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.
Pyruvate Dehydrogenase (Lipoamide)
11-beta-Hydroxysteroid Dehydrogenases
Electrophoresis, Starch Gel
Catalysis
Lignin
The most abundant natural aromatic organic polymer found in all vascular plants. Lignin together with cellulose and hemicellulose are the major cell wall components of the fibers of all wood and grass species. Lignin is composed of coniferyl, p-coumaryl, and sinapyl alcohols in varying ratios in different plant species. (From Merck Index, 11th ed)
Uridine Diphosphate Glucose Dehydrogenase
Dihydrouracil Dehydrogenase (NADP)
Gluconobacter
Protein Conformation
The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).
Stereoisomerism
Pseudomonas
Gene Expression Regulation, Enzymologic
Drosophila melanogaster
Glucosephosphate Dehydrogenase Deficiency
Saccharomyces cerevisiae
Enzyme Stability
Alanine Dehydrogenase
An NAD-dependent enzyme that catalyzes the reversible DEAMINATION of L-ALANINE to PYRUVATE and AMMONIA. The enzyme is needed for growth when ALANINE is the sole CARBON or NITROGEN source. It may also play a role in CELL WALL synthesis because L-ALANINE is an important constituent of the PEPTIDOGLYCAN layer.
Mutation
11-beta-Hydroxysteroid Dehydrogenase Type 1
Zymomonas
A genus of gram-negative, facultatively anaerobic, rod-shaped bacteria that is not known to be pathogenic for man, animals, or plants. Its organisms are spoilers for beers and ciders and in sweet English ciders they are the causative agents of a secondary fermentation known as "cider sickness." The species Z. mobilis is used for experiments in molecular genetic studies.
3-alpha-Hydroxysteroid Dehydrogenase (B-Specific)
A 3-hydroxysteroid dehydrogenase which catalyzes the reversible reduction of the active androgen, DIHYDROTESTOSTERONE to 5 ALPHA-ANDROSTANE-3 ALPHA,17 BETA-DIOL. It also has activity towards other 3-alpha-hydroxysteroids and on 9-, 11- and 15- hydroxyprostaglandins. The enzyme is B-specific in reference to the orientation of reduced NAD or NADPH.
Disulfiram
A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase.
Electrophoresis, Polyacrylamide Gel
Butylene Glycols
Fatty Alcohols
Usually high-molecular-weight, straight-chain primary alcohols, but can also range from as few as 4 carbons, derived from natural fats and oils, including lauryl, stearyl, oleyl, and linoleyl alcohols. They are used in pharmaceuticals, cosmetics, detergents, plastics, and lube oils and in textile manufacture. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
Species Specificity
The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.
Hydroxyprostaglandin Dehydrogenases
Hydroxysteroids
Spectrophotometry
Butyryl-CoA Dehydrogenase
Acinetobacter calcoaceticus
Genes
Alcohol Deterrents
Anaerobiosis
20-Hydroxysteroid Dehydrogenases
2-Propanol
Acetone
Multienzyme Complexes
Models, Molecular
Acinetobacter
Chemistry
11-beta-Hydroxysteroid Dehydrogenase Type 2
An high-affinity, NAD-dependent 11-beta-hydroxysteroid dehydrogenase that acts unidirectionally to catalyze the dehydrogenation of CORTISOL to CORTISONE. It is found predominantly in mineralocorticoid target tissues such as the KIDNEY; COLON; SWEAT GLANDS; and the PLACENTA. Absence of the enzyme leads to a fatal form of childhood hypertension termed, APPARENT MINERALOCORTICOID EXCESS SYNDROME.
Sequence Alignment
The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.
Chemical Phenomena
Polyvinyl Alcohol
Enzymes, Immobilized
Acyl-CoA Dehydrogenase, Long-Chain
Formates
Homoserine Dehydrogenase
Iodoacetates
Temperature
Pseudomonas putida
Isovaleryl-CoA Dehydrogenase
3-Isopropylmalate Dehydrogenase
Pyrazoles
Cortisone Reductase
Pyruvate Dehydrogenase (Lipoamide)-Phosphatase
Leucine Dehydrogenase
Phosphoglycerate Dehydrogenase
RNA, Messenger
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Protein Binding
Restriction Mapping
Propylene Glycol
Spectrophotometry, Ultraviolet
Estradiol Dehydrogenases
Sequence Homology, Nucleic Acid
Plasmids
D-Xylulose Reductase
Thermoanaerobacter
Succinate-Semialdehyde Dehydrogenase
An enzyme that plays a role in the GLUTAMATE and butanoate metabolism pathways by catalyzing the oxidation of succinate semialdehyde to SUCCINATE using NAD+ as a coenzyme. Deficiency of this enzyme, causes 4-hydroxybutyricaciduria, a rare inborn error in the metabolism of the neurotransmitter 4-aminobutyric acid (GABA).
Hydrogen
The first chemical element in the periodic table. It has the atomic symbol H, atomic number 1, and atomic weight [1.00784; 1.00811]. It exists, under normal conditions, as a colorless, odorless, tasteless, diatomic gas. Hydrogen ions are PROTONS. Besides the common H1 isotope, hydrogen exists as the stable isotope DEUTERIUM and the unstable, radioactive isotope TRITIUM.
Macromolecular Substances
Mitochondria
Semiautonomous, self-reproducing organelles that occur in the cytoplasm of all cells of most, but not all, eukaryotes. Each mitochondrion is surrounded by a double limiting membrane. The inner membrane is highly invaginated, and its projections are called cristae. Mitochondria are the sites of the reactions of oxidative phosphorylation, which result in the formation of ATP. They contain distinctive RIBOSOMES, transfer RNAs (RNA, TRANSFER); AMINO ACYL T RNA SYNTHETASES; and elongation and termination factors. Mitochondria depend upon genes within the nucleus of the cells in which they reside for many essential messenger RNAs (RNA, MESSENGER). Mitochondria are believed to have arisen from aerobic bacteria that established a symbiotic relationship with primitive protoeukaryotes. (King & Stansfield, A Dictionary of Genetics, 4th ed)
Enzyme Induction
Chromatography, Gel
Glucose
Glyceraldehyde-3-Phosphate Dehydrogenase (Phosphorylating)
Multigene Family
A set of genes descended by duplication and variation from some ancestral gene. Such genes may be clustered together on the same chromosome or dispersed on different chromosomes. Examples of multigene families include those that encode the hemoglobins, immunoglobulins, histocompatibility antigens, actins, tubulins, keratins, collagens, heat shock proteins, salivary glue proteins, chorion proteins, cuticle proteins, yolk proteins, and phaseolins, as well as histones, ribosomal RNA, and transfer RNA genes. The latter three are examples of reiterated genes, where hundreds of identical genes are present in a tandem array. (King & Stanfield, A Dictionary of Genetics, 4th ed)
Acetates
Models, Chemical
Vitamin A
Retinol and derivatives of retinol that play an essential role in metabolic functioning of the retina, the growth of and differentiation of epithelial tissue, the growth of bone, reproduction, and the immune response. Dietary vitamin A is derived from a variety of CAROTENOIDS found in plants. It is enriched in the liver, egg yolks, and the fat component of dairy products.
Pseudomonadaceae
Acetoin
Lactobacillus brevis
Xylitol
Clostridium
Cobalt
Cyclohexanols
Oxidoreductases Acting on CH-CH Group Donors
Apoenzymes
Prephenate Dehydrogenase
Genotype
Methylphenazonium Methosulfate
Geobacillus stearothermophilus
Chromatography, High Pressure Liquid
Hsp60 is targeted to a cryptic mitochondrion-derived organelle ("crypton") in the microaerophilic protozoan parasite Entamoeba histolytica. (1/1587)
Entamoeba histolytica is a microaerophilic protozoan parasite in which neither mitochondria nor mitochondrion-derived organelles have been previously observed. Recently, a segment of an E. histolytica gene was identified that encoded a protein similar to the mitochondrial 60-kDa heat shock protein (Hsp60 or chaperonin 60), which refolds nuclear-encoded proteins after passage through organellar membranes. The possible function and localization of the amebic Hsp60 were explored here. Like Hsp60 of mitochondria, amebic Hsp60 RNA and protein were both strongly induced by incubating parasites at 42 degreesC. 5' and 3' rapid amplifications of cDNA ends were used to obtain the entire E. histolytica hsp60 coding region, which predicted a 536-amino-acid Hsp60. The E. histolytica hsp60 gene protected from heat shock Escherichia coli groEL mutants, demonstrating the chaperonin function of the amebic Hsp60. The E. histolytica Hsp60, which lacked characteristic carboxy-terminal Gly-Met repeats, had a 21-amino-acid amino-terminal, organelle-targeting presequence that was cleaved in vivo. This presequence was necessary to target Hsp60 to one (and occasionally two or three) short, cylindrical organelle(s). In contrast, amebic alcohol dehydrogenase 1 and ferredoxin, which are bacteria-like enzymes, were diffusely distributed throughout the cytosol. We suggest that the Hsp60-associated, mitochondrion-derived organelle identified here be named "crypton," as its structure was previously hidden and its function is still cryptic. (+info)Ciprofloxacin decreases the rate of ethanol elimination in humans. (2/1587)
BACKGROUND: Extrahepatic ethanol metabolism is postulated to take place via microbial oxidation in the colon, mediated by aerobic and facultative anaerobic bacteria. AIMS: To evaluate the role of microbial ethanol oxidation in the total elimination rate of ethanol in humans by reducing gut flora with ciprofloxacin. METHODS: Ethanol was administered intravenously at the beginning and end of a one week period to eight male volunteers. Between ethanol doses volunteers received 750 mg ciprofloxacin twice daily. RESULTS: A highly significant (p=0.001) reduction in the ethanol elimination rate (EER) was detected after ciprofloxacin medication. Mean (SEM) EER was 107.0 (5.3) and 96.9 (4.8) mg/kg/h before and after ciprofloxacin, respectively. Faecal Enterobacteriaceae and Enterococcus sp. were totally absent after medication, and faecal acetaldehyde production capacity was significantly (p<0.05) decreased from 0.91 (0.15) to 0.39 (0.08) nmol/min/mg protein. Mean faecal alcohol dehydrogenase (ADH) activity was significantly (p<0. 05) decreased after medication, but ciprofloxacin did not inhibit human hepatic ADH activity in vitro. CONCLUSIONS: Ciprofloxacin treatment decreased the ethanol elimination rate by 9.4%, with a concomitant decrease in intestinal aerobic and facultative anaerobic bacteria, faecal ADH activity, and acetaldehyde production. As ciprofloxacin has no effect on liver blood flow, hepatic ADH activity, or cytochrome CYP2E1 activity, these effects are probably caused by the reduction in intestinal flora. (+info)Diet, genetic susceptibility and human cancer etiology. (3/1587)
There is evidence that high penetrance hereditary genes cause a number of relatively uncommon tumors in the familial setting, whereas common cancers are influenced by multiple loci that alter susceptibility to cancer and other conditions. The latter category of genes are involved in the metabolism of carcinogens (activation, detoxification) as well as those that interact with dietary exposure. This paper will consider some of the basic principles in studying susceptibility genes and provide a few examples in which they interact with dietary components. (+info)Ciprofloxacin administration decreases enhanced ethanol elimination in ethanol-fed rats. (4/1587)
Many colonic aerobic bacteria possess alcohol dehydrogenase (ADH) activity and are capable of oxidizing ethanol to acetaldehyde. Accordingly, some ingested ethanol can be metabolized in the colon in vivo via the bacteriocolonic pathway for ethanol oxidation. By diminishing the amount of aerobic colonic bacteria with ciprofloxacin treatment, we recently showed that the bacteriocolonic pathway may contribute up to 9% of total ethanol elimination in naive rats. In the current study we evaluated the role of the bacteriocolonic pathway in enhanced ethanol metabolism following chronic alcohol administration by diminishing the amount of gut aerobic flora by ciprofloxacin treatment. We found that ciprofloxacin treatment totally abolished the enhancement in ethanol elimination rate (EER) caused by chronic alcohol administration and significantly diminished the amount of colonic aerobic bacteria and faecal ADH activity. However, ciprofloxacin treatment had no significant effects on the hepatic microsomal ethanol-oxidizing system, hepatic ADH activity or plasma endotoxin level. Our data suggest that the decrease in the amount of the aerobic colonic bacteria and in faecal ADH activity by ciprofloxacin is primarily responsible for the decrease in the enhanced EER in rats fed alcohol chronically. Extrahepatic ethanol metabolism by gastrointestinal bacteria may therefore contribute significantly to enhanced EER. (+info)Linkage disequilibrium at the ADH2 and ADH3 loci and risk of alcoholism. (5/1587)
Two of the three class I alcohol dehydrogenase (ADH) genes (ADH2 and ADH3) encode known functional variants that act on alcohol with different efficiencies. Variants at both these genes have been implicated in alcoholism in some populations because allele frequencies differ between alcoholics and controls. Specifically, controls have higher frequencies of the variants with higher Vmax (ADH2*2 and ADH3*1). In samples both of alcoholics and of controls from three Taiwanese populations (Chinese, Ami, and Atayal) we found significant pairwise disequilibrium for all comparisons of the two functional polymorphisms and a third, presumably neutral, intronic polymorphism in ADH2. The class I ADH genes all lie within 80 kb on chromosome 4; thus, variants are not inherited independently, and haplotypes must be analyzed when evaluating the risk of alcoholism. In the Taiwanese Chinese we found that, only among those chromosomes containing the ADH3*1 variant (high Vmax), the proportions of chromosomes with ADH2*1 (low Vmax) and those with ADH2*2 (high Vmax) are significantly different between alcoholics and controls (P<10-5). The proportions of chromosomes with ADH3*1 and those with ADH3*2 are not significantly different between alcoholics and controls, on a constant ADH2 background (with ADH2*1, P=.83; with ADH2*2, P=.53). Thus, the observed differences in the frequency of the functional polymorphism at ADH3, between alcoholics and controls, can be accounted for by the disequilibrium with ADH2 in this population. (+info)Biochemical characterization of the small heat shock protein IbpB from Escherichia coli. (6/1587)
Escherichia coli IbpB was overexpressed in a strain carrying a deletion in the chromosomal ibp operon and purified by refolding. Under our experimental conditions, IbpB exhibited pronounced size heterogeneity. Basic oligomers, roughly spherical and approximately 15 nm in diameter, interacted to form larger particles in the 100-200-nm range, which themselves associated to yield loose aggregates of micrometer size. IbpB suppressed the thermal aggregation of model proteins in a concentration-dependent manner, and its CD spectrum was consistent with a mostly beta-pleated secondary structure. Incubation at high temperatures led to a partial loss of secondary structure, the progressive exposure of tryptophan residues to the solvent, the dissociation of high molecular mass aggregates into approximately 600-kDa oligomers, and an increase in surface hydrophobicity. Structural changes were reversible between 37 and 55 degrees C, and, up to 55 degrees C, hydrophobic sites were reburied upon cooling. IbpB exhibited a biphasic unfolding trend upon guanidine hydrochloride (GdnHCl) treatment and underwent comparable conformational changes upon melting and during the first GdnHCl-induced transition. However, hydrophobicity decreased with increasing GdnHCl concentrations, suggesting that efficient exposure of structured hydrophobic sites involves denaturant-sensitive structural features. By contrast, IbpB hydrophobicity rose at high NaCl concentrations and increased further at high temperatures. Our results support a model in which temperature-driven conformational changes lead to the reversible exposure of normally shielded binding sites for nonnative proteins and suggest that both hydrophobicity and charge context may determine substrate binding to IbpB. (+info)Nonsense mutations in the alcohol dehydrogenase gene of Drosophila melanogaster correlate with an abnormal 3' end processing of the corresponding pre-mRNA. (7/1587)
From bacteria to mammals, mutations that generate premature termination codons have been shown to result in the reduction in the abundance of the corresponding mRNA. In mammalian cells, more often than not, the reduction happens while the RNA is still associated with the nucleus. Here, it is reported that mutations in the alcohol dehydrogenase gene (Adh) of Drosophila melanogaster that generate premature termination codons lead to reduced levels of cytoplasmic and nuclear mRNA. Unexpectedly, it has been found that the poly(A) tails of Adh mRNAs and pre-mRNAs that carry a premature termination codon are longer than in the wild-type transcript. The more 5' terminal the mutation is, the longer is the poly(A) tail of the transcript. These findings suggest that the integrity of the coding region may be required for accurate mRNA 3' end processing. (+info)Drosophila lebanonensis alcohol dehydrogenase: pH dependence of the kinetic coefficients. (8/1587)
The alcohol dehydrogenase (ADH) from Drosophila lebanonensis shows 82% positional identity to the alcohol dehydrogenases from Drosophila melanogaster. These insect ADHs belong to the short-chain dehydrogenase/reductase family which lack metal ions in their active site. In this family, it appears that the function of zinc in medium chain dehydrogenases has been replaced by three amino acids, Ser138, Tyr151 and Lys155. The present work on D. lebanonensis ADH has been performed in order to obtain information about reaction mechanism, and possible differences in topology and electrostatic properties in the vicinity of the catalytic residues in ADHs from various species of Drosophila. Thus the pH dependence of various kinetic coefficients has been studied. Both in the oxidation of alcohols and in the reduction of aldehydes, the reaction mechanism of D. lebanonensis ADH in the pH 6-10 region was consistent with a compulsory ordered pathway, with the coenzymes as the outer substrates. Over the entire pH region, the rate limiting step for the oxidation of secondary alcohols such as propan-2-ol was the release of the coenzyme product from the enzyme-NADH complex. In the oxidation of ethanol at least two steps were rate limiting, the hydride transfer step and the dissociation of NADH from the binary enzyme-NADH product complex. In the reduction of acetaldehyde, the rate limiting step was the dissociation of NAD+ from the binary enzyme-NAD+ product complex. The pH dependences of the kon velocity curves for the two coenzymes were the opposite of each other, i.e. kon increased for NAD+ and decreased for NADH with increasing pH. The two curves appeared complex and the kon velocity for the two coenzymes seemed to be regulated by several groups in the free enzyme. The kon velocity for ethanol and the ethanol competitive inhibitor pyrazole increased with pH and was regulated through the ionization of a single group in the binary enzyme-NAD+ complex, with a pKa value of 7.1. The kon velocity for acetaldehyde was pH independent and showed that in the enzyme-NADH complex, the pKa value of the catalytic residue must be above 10. The koff velocity of NAD+ appeared to be partly regulated by the catalytic residue, and protonation resulted in an increased dissociation rate. The koff velocity for NADH and the hydride transfer step was pH independent. In D. lebanonensis ADH, the pKa value of the catalytic residue was 0.5 pH units lower than in the ADHS alleloenzyme from D. melanogaster. Thus it can be concluded that while most of the topology of the active site is mainly conserved in these two distantly related enzymes, the microenvironment and electrostatic properties around the catalytic residues differ. (+info)
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Isolation and DNA sequence of ADH3, a nuclear gene encoding the mitochondrial isozyme of alcohol dehydrogenase in Saccharomyces...
Computational studies of human class V alcohol dehydrogenase - the odd sibling
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How to Prevent Hangovers: Understanding the Physiology of Alcohol & Using It To Our Benefit - Distilled Science
ADH4 - Wikipedia
Short-term effects of alcohol consumption
Short-term effects of alcohol consumption - Wikipedia
Pharmaceutics | Free Full-Text | Encapsulation of Alcohol Dehydrogenase in Mannitol by Spray Drying
Extreme halophilic alcohol dehydrogenase mediated highly efficient syntheses of enantiopure aromatic alcohols - Nottingham...
Molecular systematics of the genus Neotoma based on DNA sequences from intron 2 of the alcohol dehydrogenase gene<...
Regulation of the expression of the rat alcohol dehydrogenase gene by glucocorticoids.<...
DSpace at EWHA: 노랑초파리 (Drosophila melanogaster)의 발생과정 중 threonine이 Adh유전자의 발현에 미치는 영향
Alkohol dehidrogenase - Wikipedia bahasa Indonesia, ensiklopedia bebas
CiNii 論文 -
Root specific expression of Na^+/H^+ antiporter gene from Synechocystis sp. PCC...
Design of Experiments Methodology to Build a Multifactorial Statistical Model Describing the Metabolic Interactions of Alcohol...
1cdo - Proteopedia, life in 3D
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Human ADH5 cDNA ORF Clone, N-HA tag, HG17057-NY | Sino Biological
Recombinant Human ADH5 protein (ab124573) References
Alcohol flush reaction - wikidoc
Cocarcinogenic effects of alcohol in hepatocarcinogenesis | Gut
ADH genotypes and alcohol use and dependence in Europeans
British Library EThOS: Consequences of the interaction of amyloid beta with amyloid binding alcohol dehydrogenase and the...
Identification of functional regions in the yeast transcriptional activator ADR1. | Molecular and Cellular Biology
Hominids adapted to metabolize ethanol long before human-directed fermentation | PNAS
Hominids adapted to metabolize ethanol long before human-directed fermentation<...
Remote sensing of gene expression in Planta: transgenic plants as monitors of exogenous stress perception in extraterrestrial...
Losing the wine flush: a cure for the red face : Vinography
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SWISS-MODEL Template Library | 3cos
DISEASES - SORD
EC 1.1.99.36
Best friends drinking can negate the protective effects of an alcohol dehydrogenase 1B gene variant | EurekAlert! Science News
Human ADH1(Alcohol Dehydrogenase 1) ELISA Kit - Dla Różnorodności Biologicznej - Life Sciences
Cross-reactive monoclonal antibodies to alcohol dehydrogenases | SpringerLink
RCSB PDB
- 1MGO: Horse Liver Alcohol Dehydrogenase Phe93Ala Mutant Literature Report Page
RCSB PDB
- 1A72: AN ACTIVE-SITE DOUBLE MUTANT (PHE93->TRP, VAL203->ALA) OF HORSE LIVER ALCOHOL DEHYDROGENASE IN...
Frontiers | Prioritized Expression of BDH2 under Bulk Translational Repression and Its Contribution to Tolerance to Severe...
Heres why some people turn super-red after drinking alcohol - Science News Hub
Molecular Biosciences
Etanolmetabolismen ur ett alkoholistperspektiv : Kemin vid nedbrytning av etanol i kroppen, dess betydelse för kroppens kemiska...
PROSITE
Minerals ~ Zinc
Alcohol dehydrogenase activity in mouse brown adipose tissue
- Manipal Academy of Higher Education, Manipal, India
Characterization of new medium-chain alcohol dehydrogenases adds resolution to duplications of the class I/III and the sub...
Induction by ethanol of alcohol dehydrogenase activity in Acetobacter pasteurianus. | Journal of Bacteriology
Effects of Trehalose on Pressure-Induced Inactivation of Yeast Alcohol Dehydrogenase | Bentham Science
Translation Initiation in Drosophila melanogaster Is Reduced by Mutations Upstream of the AUG Initiator Codon<...
Hydride transfer in liver alcohol dehydrogenase: Quantum dynamics, kinetic isotope effects, and role of enzyme motion<...
Preventive Nutrition and Food Science
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fruit fly size
Why Does Alcohol Make Your Face Red? - Purple Tree
Alcohol metabolism | definition of Alcohol metabolism by Medical dictionary
Ethanol and galactose metabolism as influenced by 4-methylpyrazole in alcoholics with and without nutritional deficiencies....
ADH promoter control in S.cerevisiae?
Influence of temperature on the production of archaeal thermoactive alcohol dehydrogenases from Pyrococcus furiosus with...
JCI -
Schwann cells expressing nociceptive channel TRPA1 orchestrate ethanol-evoked neuropathic pain in mice
JCI -
Schwann cells expressing nociceptive channel TRPA1 orchestrate ethanol-evoked neuropathic pain in mice
Human Metabolome Database: Showing metabocard for Methanol (HMDB0001875)
Suspicious News: How to Drink All Night Without Getting Drunk
Description: Increasing the NADPH supply for whole-cell biotransformation and development of a novel biosensor
Characterization of polymorphisms of genes ADH2, ADH3, ALDH2 and CYP2E1 and relationship to the alcoholism in a Colombian...
Molecular Characterization of Zinc- and Iron- Containing Alcohol Dehydrogenases from Anaerobic Hyperthermophiles
Drosophila genetics in the classroom. | Genetics
Drosophila melanogaster Adult enhancer factor 1 (Aef1) GENTAUR-58b433fb7eca0 | Gentaursearch
Incorporation of the genetic control of alcohol dehydrogenase into a physiologically based pharmacokinetic model for ethanol in...
Metabolism and pharmacokinetics of 3-n-butylphthalide (NBP) in humans: the role of cytochrome P450s and alcohol dehydrogenase...
Acetaldehyde as an underestimated risk factor for cancer development: role of genetics in ethanol metabolism | Genes &...
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Association of ADH4 genetic variants with alcohol dependence risk...: Ingenta Connect
Predisposición genética en el consumo de alcohol: el caso de la Alcohol Deshidrogenasa 1C
adh - Alcohol dehydrogenase - Staphylococcus epidermidis (strain ATCC 35984 / RP62A) - adh gene & protein
How Coca-Colas Pro-Aspartame PR Misleads the Public - RiseEarth
Monkey ADH1(Alcohol Dehydrogenase 1) ELISA Kit - Kits de ELISA, Proteínas, Anticorpos | ABKIT
ADH1 - Alcohol dehydrogenase 1 - Apteryx australis (Southern brown kiwi) - ADH1 gene & protein
Alcohol metabolism - University of Missouri Libraries
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Highlighting PQQ research
Alcohol dehydrogenase 1C*1 allele is a genetic marker for alcohol-associated cancer in heavy drinkers. - PubMed - NCBI
UniProt: P0A9Q7
An automatic apparatus for the study of enzyme kinetics | Biochemical Journal
Gastrointestinal alcohol dehydrogenase. - PubMed - NCBI
In vivo footprinting reveals unique cis-elements and different modes of hypoxic induction in maize Adh1 and Adh2. | Plant Cell
PTGR1 Gene - GeneCards | PTGR1 Protein | PTGR1 Antibody
Gösta Pettersson (biochemist)
... especially for the enzyme alcohol dehydrogenase. He has written a text book on enzyme kinetics He also made contributions in ... Liver alcohol dehydrogenase. http://www.tandfonline.com/doi/abs/10.3109/10409238609113616 G. Pettersson, 1975 (in Swedish). ...
Ethanol fermentation
"Yeast alcohol dehydrogenase structure and catalysis". Biochemistry. 53: 5791-803. doi:10.1021/bi5006442. PMC 4165444. PMID ... This reaction is catalyzed by alcohol dehydrogenase (ADH1 in baker's yeast).[3] ... The Alcohol Fuel Handbook. InfinityPublishing.com. ISBN 0-7414-0646-2.. *^ Gil, C.; Gómez-Cordovés, C. (1986). "Tryptophol ... "The Alcohol Content of Bread". Canadian Medical Association Journal. 16 (11): 1394-5. November 1926. PMC 1709087. PMID 20316063 ...
Neomycin
... a putative alcohol dehydrogenase gene (btrE, neo5); another putative dehydrogenase (similar to chorine dehydrogenase and ...
Metronidazole
Gupta NK, Woodley CL, Fried R (October 1970). "Effect of metronidazole on liver alcohol dehydrogenase". Biochemical ... Consuming alcohol while taking metronidazole has been suspected in case reports to cause a disulfiram-like reaction with ... some studies call into question the mechanism of the interaction of alcohol and metronidazole,[40][41][42] and a possible ... People are often advised not to drink alcohol during systemic metronidazole therapy and for at least 48 hours after completion ...
2,2,2-Trifluoroethanol
It competitively inhibits alcohol dehydrogenase for example. [5] Reactions[edit]. Oxidation of trifluoroethanol yields ... Also known as TFE or trifluoroethyl alcohol, this colourless, water-miscible liquid has a smell reminiscent of ethanol. Due to ... Positive modulators: Alcohols (e.g., brometone, chlorobutanol (chloretone), ethanol (alcohol), tert-butanol (2M2P), ... the electronegativity of the trifluoromethyl group, this alcohol exhibits a stronger acidic character compared to ethanol. Thus ...
Oxidoreductase
Alcohol + NADP+ ⇌. {\displaystyle \rightleftharpoons }. Aldehyde + NADPH + H+ Alcoholdehydrogenase (NADP+) Ja 1.1.1.3 L- ... oxoglutarate dehydrogenase (succinyl-transferring) Ja 1.2.4.4 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl- ... Alcohol + NAD+ ⇌. {\displaystyle \rightleftharpoons }. Aldehyde of keton + NADH + H+ Alcoholdehydrogenase (NAD+) Ja ... L-iditol 2-dehydrogenase Ja 1.1.1.15 D-iditol + NAD+ ⇌. {\displaystyle \rightleftharpoons }. D-sorbose + NADH + H+ D-iditol 2- ...
Crabtree effect
Thomson JM, Gaucher EA, Burgan MF, De Kee DW, Li T, Aris JP, Benner SA (2005). "Resurrecting ancestral alcohol dehydrogenases ... This critical value, above which alcoholic fermentation occurs, is dependent on the strain and the culture conditions. More ... alcohol) in aerobic conditions at high external glucose concentrations rather than producing biomass via the tricarboxylic acid ... recent evidences demonstrated that the occurrence of alcoholic fermentation is not primarily due to a limited respiratory ...
Azotobacter
Gama-Castro S.; Núñez C.; Segura D.; Moreno S.; Guzmán J. & Espín G. (2001). "Azotobacter vinelandii Aldehyde Dehydrogenase ... Regulated by ς54: Role in Alcohol Catabolism and Encystment". Journal of Bacteriology. 183 (21): 6169-6174. doi:10.1128/JB. ... it is also affected by aldehyde dehydrogenase[13] and the response regulator AlgR.[14] ...
Alkohol dehidrogenase bahasa Indonesia, ensiklopedia bebas
... alcohol dehydrogenase (NAD); aliphatic alcohol dehydrogenase; ethanol dehydrogenase; NAD-dependent alcohol dehydrogenase; NAD- ... NADH-alcohol dehydrogenase; NADH-aldehyde dehydrogenase; primary alcohol dehydrogenase; yeast alcohol dehydrogenase, NAD+ ...
Frank Westheimer
I. The Reaction Catalyzed by Alcohol Dehydrogenase". J. Biol. Chem. 202 (2): 687-697. PMID 13061492. Loewus, F. A.; Ofner, P.; ... In 1953, soon after completing the work on alcohol dehydrogenase, Westheimer moved to Harvard University. He continued his ... Vennesland had developed a project involving the fate of hydrogen atoms in alcohol dehydrogenase. Vennesland and Fisher's ... based on the idea of enantiotopicity to explain how the enzyme alcohol dehydrogenase removed hydrogen from the alcohol molecule ...
S-Nitrosoglutathione
Jensen DE, Belka GK, Du Bois GC (April 1998). "S-Nitrosoglutathione is a substrate for rat alcohol dehydrogenase class III ... Staab CA, Alander J, Morgenstern R, Grafström RC, Höög JO (March 2009). "The Janus face of alcohol dehydrogenase 3". Chem. Biol ... Hedberg JJ, Griffiths WJ, Nilsson SJ, Höög JO (March 2003). "Reduction of S-nitrosoglutathione by human alcohol dehydrogenase 3 ...
ADH7
This gene encodes class IV alcohol dehydrogenase 7 mu or sigma subunit, which is a member of the alcohol dehydrogenase family. ... "The complete structure of human class IV alcohol dehydrogenase (retinol dehydrogenase) determined from the ADH7 gene". The ... Alcohol dehydrogenase class 4 mu/sigma chain is an enzyme that in humans is encoded by the ADH7 gene. ... "Entrez Gene: ADH7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide". Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ...
Artificial metalloenzyme
"Biocatalyst-artificial metalloenzyme cascade based on alcohol dehydrogenase". Chemical Science. Royal Society of Chemistry. 9 ( ... For example, Mutant L124V can selectively reduce certain ketone into R-alcohol while S112A-K121N can reduce the same substance ... So far, ArMs can catalyze a lot of chemical reactions, such as: allylic alkylation, allylic amination, aldol reation, alcohol ... into S-alcohol. Play media Besides biotin-avidin based ArMs, another important attempt utilizing supuramolecular interaction is ...
Ethylene glycol poisoning
Fomepizole is a potent inhibitor of alcohol dehydrogenase; similar to ethanol, it acts to block the formation of the toxic ... Initially it is metabolized by alcohol dehydrogenase to glycolaldehyde, which is then oxidized to glycolic acid by aldehyde ... Ethanol acts by competing with ethylene glycol for alcohol dehydrogenase, the first enzyme in the degradation pathway. Because ... Many cases of poisoning are the result of using ethylene glycol as a cheap substitute for alcohol or intentional ingestions in ...
Rhodomicrobium vannielii
Sandhu GR, Carr NG (1970). "A novel alcohol dehydrogenase present in Rhodomicrobium vannielii". Archiv für Mikrobiologie. 70 (4 ...
Enzyme
Examples are lactase, alcohol dehydrogenase and DNA polymerase. Different enzymes that catalyze the same chemical reaction are ... He wrote that "alcoholic fermentation is an act correlated with the life and organization of the yeast cells, not with the ... A few decades later, when studying the fermentation of sugar to alcohol by yeast, Louis Pasteur concluded that this ... a molecule containing an alcohol group (EC 2.7.1). Sequence similarity. EC categories do not reflect sequence similarity. For ...
Drosophila melanogaster
Adh: Alcohol dehydrogenase- Drosophila melanogaster can express the alcohol dehydrogenase (ADH) mutation, thereby preventing ... "Drosophila melanogaster alcohol dehydrogenase: mechanism of aldehyde oxidation and dismutation". The Biochemical Journal. 329 ( ... "Deletion of a conserved regulatory element in the Drosophila Adh gene leads to increased alcohol dehydrogenase activity but ... "Alpha-ketoglutarate reduces ethanol toxicity in Drosophila melanogaster by enhancing alcohol dehydrogenase activity and ...
Retinyl palmitate
"Characterization of Esterase and Alcohol Dehydrogenase Activity in Skin. Metabolism of Retinyl Palmitate to Retinol (Vitamin A ... Palmitate is attached to the alcohol form of vitamin A, retinol, in order to make vitamin A stable in milk.[citation needed] ...
Tris(tert-butoxy)silanethiol
Modeling of the Alcohol Dehydrogenase Active Site: Two Different Modes of Alcohol Binding in Crystals of Zinc and Cadmium Tri- ... A. Dołęga: Alcohol dehydrogenase and its simple inorganic models. Coord. Chem. Rev. 254 (2010) 916-937. A. Pladzyk, Ł. ...
HSD17B4
It's an alcohol oxidoreductase, specifically 17β-Hydroxysteroid dehydrogenase. It is involved in fatty acid β-oxidation and ... 17beta-hydroxysteroid dehydrogenase 4 and D-3-hydroxyacyl-coenzyme A dehydrogenase/hydratase involved in Zellweger syndrome". ... It was first identified as a 17-beta-estradiol dehydrogenase (Leenders et al., 1996; van Grunsven et al., 1998). Peroxisomal ... Green VL, Speirs V, Landolt AM, Foy PM, Atkin SL (April 1999). "17Beta-hydroxysteroid dehydrogenase type 1, 2, 3, and 4 ...
ADH1C
This gene encodes class I alcohol dehydrogenase, gamma subunit, which is a member of the alcohol dehydrogenase family. Members ... "Entrez Gene: ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide". Seitz HK, Meier P (Jun 2007). "The role of ... Class I alcohol dehydrogenase, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibit high ... Xu YL, Carr LG, Bosron WF, Li TK, Edenberg HJ (Apr 1988). "Genotyping of human alcohol dehydrogenases at the ADH2 and ADH3 loci ...
Antimicrobial surface
Snodgrass, P. J.; Vallee, B. L.; Hoch, F. L. (1960). "Effects of silver and mercurials on yeast alcohol dehydrogenase". J. Biol ... These ions can inhibit oxidative enzymes such as yeast alcohol dehydrogenase. Silver ions have also been shown to interact with ...
Abacavir
Ethanol may result in increased levels of abacavir through the inhibition of alcohol dehydrogenase. Abacavir is metabolized by ... Abacavir is metabolized primarily through the enzymes alcohol dehydrogenase and glucuronyl transferase to an inactive ... Abacavir is metabolized by both alcohol dehydrogenase and glucuronidation. ... both alcohol dehydrogenase and glucuronidation. Methadone may diminish the therapeutic effect of Abacavir. Abacavir may ...
Fomepizole
... is a competitive inhibitor of the enzyme alcohol dehydrogenase, found in the liver. This enzyme plays a key role in ... Fomepizole slows the production of acetaldehyde by inhibiting alcohol dehydrogenase, which in turn allows more time to further ... By competitively inhibiting the first enzyme, alcohol dehydrogenase, in the metabolism of ethylene glycol and methanol, ... Methanol is first metabolized to formaldehyde by alcohol dehydrogenase. Formaldehyde then undergoes further oxidation, via ...
Acidogenesis
... and NADPH-linked alcohol dehydrogenase. By its side, the acidogenic activity was found in the early 20th century, but it was ... activated lactate dehydrogenase; H2 by pyruvate ferredoxin oxidoreductase and hydrogenase; and ethanol via NADH- ...
Corneal keratocyte
According to one study, patient's keratocytes have decreased levels of one of the alcohol dehydrogenase subforms, they secrete ... Mootha VV, Kanoff JM, Shankardas J, Dimitrijevich S (2009). "Marked reduction of alcohol dehydrogenase in keratoconus corneal ...
FGFBP1
Lange LG, Sytkowski AJ, Vallee BL (1976). "Human liver alcohol dehydrogenase: purification, composition, and catalytic features ...
Aerobic fermentation
Pyruvate is converted to acetaldehyde by Pdc and then acetaldehyde is converted to ethanol by alcohol dehydrogenase (Adh). ... "Resurrecting ancestral alcohol dehydrogenases from yeast". Nature Genetics. 37 (6): 630-635. doi:10.1038/ng1553. PMC 3618678. ... Alcoholic fermentation is often used by plants in anaerobic conditions to produce ATP and regenerate NAD+ to allow for ... Beer and other alcoholic beverages, throughout human history, have played a significant role in society through drinking ...
Mineral (nutrient)
Pervasive and required for several enzymes such as carboxypeptidase, liver alcohol dehydrogenase, and carbonic anhydrase ...
MT-TI
Isocitrate dehydrogenase. *Oxoglutarate dehydrogenase complex. *Succinyl coenzyme A synthetase. *Fumarase. *Malate ...
Alkoholna dehidrogenaza
Sund, H. and Theorell, H. (1963). "Alcohol dehydrogenase". u Boyer, P.D., Lardy, H. and Myrbäck, K. The Enzymes 7 (2nd iz.). ... Brändén, G.-I., Jörnvall, H., Eklund, H. and Furugren, B. (1975). "Alcohol dehydrogenase". u Boyer, P.D. The Enzymes 11 (3rd iz ... Theorell, H. (1958). "Kinetics and equilibria in the liver alcohol dehydrogenase system". Adv. Enzymol. Relat. Subj. Biochem. ... Alcohol dehydrogenase na US National Library of Medicine Medical Subject Headings (MeSH) ...
Peroxisome
... and alcohol, by means of the peroxidation reaction: H. 2. O. 2. +. R. ′. H. 2. →. R. ′. +. 2. H. 2. O. {\displaystyle \mathrm { ... and the NADP-dehydrogenases of the pentose-phosphate pathway. It has been demonstrated that peroxisomes generate superoxide (O2 ... About 25% of the ethanol alcohol humans drink is oxidized to acetaldehyde in this way.[8] In addition, when excess H2O2 ...
L-xylulose reductase
Oxidoreductases: alcohol oxidoreductases (EC 1.1). 1.1.1: NAD/NADP acceptor. *3-hydroxyacyl-CoA dehydrogenase ...
효소 - 위키백과, 우리 모두의 백과사전
효소의 이름은 보통 효소의 기질이나 효소가 촉매하는 화학 반응에서 유래된 단어 끝에 접미사 "-에이스(-ase)"를 붙여서 짓는다.[2] 락테이스(lactase), 알코올 탈수소효소(alcohol dehydrogenase), ...
Vitamin C
l-galactonolactone dehydrogenase.[131] to produce ascorbic acid.[122] l-Ascorbic acid has a negative feedback on l-galactose ... The aldehyde group of this compound is reduced to a primary alcohol using the enzyme glucuronate reductase and the cofactor ... l-galactose dehydrogenase, whereby the lactone ring opens and forms again but with between the carbonyl on C1 and hydroxyl ... UDP-glucose 6-dehydrogenase uses the co-factor NAD+ as the electron acceptor. The transferase UDP-glucuronate pyrophosphorylase ...
Vitamin C
UDP-glucose 6-dehydrogenase uses the co-factor NAD+ as the electron acceptor. The transferase UDP-glucuronate pyrophosphorylase ... The aldehyde group of this compound is reduced to a primary alcohol using the enzyme glucuronate reductase and the cofactor ... Leferink, N. G.; van den Berg, W. A.; van Berkel, W. J. (2008). "L-Galactono-γ-lactone Dehydrogenase from Arabidopsis thaliana ... L-Galactose reacts with the enzyme L-galactose dehydrogenase, whereby the lactone ring opens and forms again but with between ...
Homoisocitrate dehydrogenase
Oxidoreductases: alcohol oxidoreductases (EC 1.1). 1.1.1: NAD/NADP acceptor. *3-hydroxyacyl-CoA dehydrogenase ... Other names in common use include 2-hydroxy-3-carboxyadipate dehydrogenase, 3-carboxy-2-hydroxyadipate dehydrogenase, ... In enzymology, a homoisocitrate dehydrogenase (EC 1.1.1.87) is an enzyme that catalyzes the chemical reaction ... Rowley B, Tucci AF (1970). "Homoisocitric dehydrogenase from yeast". Arch. Biochem. Biophys. 141 (2): 499-, 510. doi:10.1016/ ...
Blood alcohol content
Alcohol is metabolized mainly by the group of six enzymes collectively called alcohol dehydrogenase. These convert the ethanol ... Blood alcohol content (BAC), also called blood alcohol concentration or blood alcohol level, is a measurement of alcohol ... Blood alcohol content, blood ethanol concentration, blood alcohol level, blood alcohol concentration, blood alcohol. ... Furthermore, alcohol dehydrogenase is present in the stomach lining. After absorption, the alcohol passes to the liver through ...
AKR1B1
alcohol dehydrogenase (NADP+) activity. • retinal dehydrogenase activity. • allyl-alcohol dehydrogenase activity. • NADP- ... retinol dehydrogenase activity. Cellular component. • mast cell granule. • Schwann cell microvillus. • Schmidt-Lanterman ... dependent enzyme catalyzing the reduction of various aldehydes and ketones to the corresponding alcohol. The involvement in ... dependent enzyme catalyzing the reduction of various aldehydes and ketones to the corresponding alcohol. It also participates ...
Retinal
catalyzed by retinol dehydrogenases (RDHs)[9] and alcohol dehydrogenases (ADHs).[10] Retinol is called vitamin A alcohol, or ... catalyzed by retinal dehydrogenases[11] also known as retinaldehyde dehydrogenases (RALDHs)[10] as well as retinal oxidases.[12 ... all-trans-retinal + NADPH + H+ → all-trans-retinol + NADP+; all-trans-retinol dehydrogenases, ... 11-cis-retinol + NAD+ → 11-cis-retinal + NADH + H+; 11-cis-retinol dehydrogenases, ...
Hypotaurine
Positive modulators: Alcohols (e.g., brometone, chlorobutanol (chloretone), ethanol (alcohol), tert-butanol (2M2P), ... Hypotaurine is enzymatically oxidized to yield taurine by hypotaurine dehydrogenase.[2] Hypotaurine (3) is an intermediate in ...
Hyperuricemia
... and consumption of excess alcoholic beverages.[4] Of these, alcohol consumption is the most important.[5] ... and is a possible weak inhibitor of xanthine dehydrogenase. As a byproduct of its fermentation process, beer additionally ... High intake of alcohol (ethanol), a significant cause of hyperuricemia, has a dual action that is compounded by multiple ... Mixed causes include high levels of alcohol and/or fructose in the diet, and starvation. ...
Ataxia
Succinic semialdehyde dehydrogenase deficiency[edit]. Succinic semialdehyde dehydrogenase deficiency is an autosomal-recessive ... List of countries by alcohol consumption per capita *Alcohol consumption by youth in the United States ... The most common example is ethanol (alcohol), which is capable of causing reversible cerebellar and vestibular ataxia. Other ... Non-hereditary causes of cerebellar degeneration include chronic alcohol abuse, head injury, paraneoplastic and non- ...
Arachidonate 5-lipoxygenase
5-HETE may be further metabolized by 5-Hydroxyeicosanoid dehydrogenase (5-HEDH) to 5-oxo-eicosatetraenoic acid (5-oxo-ETE). ... it may also contribute to hypersensitivity responses of the respiratory system to cold air and possibly even alcohol beverages ... may then be released by the enzyme and rapidly reduced by cellular glutathione peroxidases to its corresponding alcohol, 5(S)- ...
Alcohol intolerance
Acute alcohol sensitivity. Alcohol intolerance is due to a genetic polymorphism of the enzyme alcohol dehydrogenase, the enzyme ... Congener (Alcohol congener analysis). *Ethanol (Blood alcohol content, Breathalyzer, Recommended maximum intake of alcoholic ... Alcohol flush reaction. References[edit]. *^ "Acute alcohol sensitivity , Genetic and Rare Diseases Information Center (GARD ... similar to alcohol-containing medications, vinegar, inhalation of alcohol or the vapour of alcohol-containing cleaning agents. ...
AKR1A1 - Wicipedia
retinol dehydrogenase activity. • allyl-alcohol dehydrogenase activity. Cydrannau o'r gell. • cytosol. • extracellular exosome ... alcohol dehydrogenase (NADP+) activity. • protein binding. • aldo-keto reductase (NADP) activity. • L-glucuronate reductase ...
Jet injector
... showed that jet injectors would frequently transmit the viral infection lactate dehydrogenase elevating virus (LDV) from one ... beyond the reach of alcohol swabbing or acetone swabbing)," stated Dr. Bruce Weniger.[15] ...
Secondary hypertension
Drugs: In particular, alcohol, nasal decongestants with adrenergic effects, NSAIDs, MAOIs, adrenoceptor stimulants, and ... Vantyghem MC, Marcelli-Tourvieille S, Defrance F, Wemeau JL (October 2007). "11beta-hydroxysteroide dehydrogenases. Recent ... involves a defect in the gene for 11β-hydroxysteroid dehydrogenase, an enzyme that normally inactivates circulating cortisol to ... by causing inhibition of the 11β-hydroxysteroid dehydrogenase enzyme and likewise leading to secondary apparent ...
Co-factor - Simple English Wikipedia, the free encyclopedia
Alcohol dehydrogenase. Carbonic anhydrase. DNA polymerase A simple [Fe2S2] cluster containing two iron atoms and two sulfur ...
Carbon monoxide
In bacteria, carbon monoxide is produced via the reduction of carbon dioxide by the enzyme carbon monoxide dehydrogenase, an Fe ...
Aspirin
Livingstone FB (1985). Frequencies of hemoglobin variants: thalassemia, the glucose-6-phosphate dehydrogenase deficiency, G6PD ... Chyka PA, Erdman AR, Christianson G, Wax PM, Booze LL, Manoguerra AS, Caravati EM, Nelson LS, Olson KR, Cobaugh DJ, Scharman EJ ... For example, acetazolamide and ammonium chloride are known to enhance the intoxicating effect of salicylates, and alcohol also ... drink alcohol, take other NSAIDs, or are on other blood thinners.[4] Aspirin is not recommended in the last part of pregnancy.[ ...
Hangover
After being ingested, the ethanol in alcoholic beverages is first converted to acetaldehyde by the enzyme alcohol dehydrogenase ... This is thought to be caused by declining supplies of alcohol dehydrogenase, the enzyme involved in metabolizing alcohol. ... doi:10.1016/j.alcohol.2007.07.009. PMID 17980785.. *^ Ylikahri R, Heikkonen E, Soukas A (1988). "The sauna and alcohol". Annals ... For example, some people (predominantly East Asians) have a mutation in their alcohol dehydrogenase gene that makes this enzyme ...
RNA interference
... gene silencing of Alcohol dehydrogenase by white-Adh transgenes is Polycomb dependent". Cell. 90 (3): 479-90. doi:10.1016/S0092 ...
Ætanol, den frie encyklopædi
"Does alcohol burn off in cooking?". Ochef.com. Hentet 2009-08-29.. ... af acetaldehyd dehydrogenase samt af xanthin oxidase, de to sidstnævnte enzymer hæmmes af et nedbrydningsprodukt af antabus, ... 2003-12-05, Science Daily: Moderate Alcohol Consumption Linked To Brain Shrinkage Citat: "...found a link between low to ... "Our findings do not support the hypothesis that low or moderate alcohol intake offers any protection against cerebral ...
Interferencia de ARN, a enciclopedia libre
Pal-Bhadra M, Bhadra U, Birchler J (1997). "Cosuppression in Drosophila: gene silencing of Alcohol dehydrogenase by white-Adh ...
Lactate dehydrogenase
Ethanol is dehydrogenated to acetaldehyde by alcohol dehydrogenase, and further into acetic acid by acetaldehyde dehydrogenase ... lactate dehydrogenase A. (subunit M). Human lactate dehydrogenase M4 (the isoenzyme found in skeletal muscle). From PDB: 1I10. ... D-lactate dehydrogenase, membrane binding. crystal structure of d-lactate dehydrogenase, a peripheral membrane respiratory ... Lactate dehydrogenase-A deficiency is caused by a mutation to the LDHA gene, while lactate dehydrogenase-B deficiency is caused ...
Cyclophosphamide
Most of the aldophosphamide is then oxidised by the enzyme aldehyde dehydrogenase (ALDH) to make carboxycyclophosphamide. A ... alcohol, barbiturates, rifampicin, or phenytoin) may result in accelerated metabolism of cyclophosphamide into its active ... Kohn FR, Sladek NE (1985). "Aldehyde dehydrogenase activity as the basis for the relative insensitivity of murine pluripotent ...
Gastrointestinal alcohol dehydrogenase. - PubMed - NCBI
Gastrointestinal alcohol dehydrogenase.. Seitz HK1, Oneta CM.. Author information. 1. Department of Medicine, Salem Medical ... Alcohol dehydrogenase (ADH) consists of a family of isozymes that convert alcohols to their corresponding aldehydes using NAD+ ... and its inhibition by alcohol may lead to an alteration of epithelial cell differentiation and cell growth and may also be ... toxic compound that binds to cellular protein and DNA if not further metabolized to acetate by acetaldehyde dehydrogenase ...
Mammalian alcohol dehydrogenase - Functional and structural implications | SpringerLink
Mammalian alcohol dehydrogenase (ADH) constitutes a complex system with different forms and extensive multiplicity (ADH1-ADH6) ... Jörnvall H, Höög J-O. Nomenclature of alcohol dehydrogenases. Alcohol Alcohol 30:153-161;1995.PubMedGoogle Scholar ... Human liver class I alcohol dehydrogenase γγ isozyme: The sole cytosolic 3β-hydroxysteroid dehydrogenase of iso-bile acids. ... Three-dimensional structure of horse liver alcohol dehydrogenase at 2.4 Å resolution. J Mol Biol 102:27-59;1976.PubMedGoogle ...
Alcohol dehydrogenase - Wikipedia
Alcohol dehydrogenase (NAD(P)+) Aldehyde dehydrogenase Oxidoreductase Blood alcohol content for rates of metabolism This ... Edenberg HJ, McClintick JN (October 2018). "Alcohol dehydrogenases, aldehyde dehydrogenases and alcohol use disorders: a ... Edenberg HJ, McClintick JN (December 2018). "Alcohol Dehydrogenases, Aldehyde Dehydrogenases, and Alcohol Use Disorders: A ... alcohol dehydrogenases. Brewers yeast also has another alcohol dehydrogenase, ADH2, which evolved out of a duplicate version ...
Alcohol dehydrogenase 1 - Catharanthus roseus (Madagascar periwinkle)
Belongs to the zinc-containing alcohol dehydrogenase family. Class-P subfamily.Sequence analysis ... sp,P85440,ADH1_CATRO Alcohol dehydrogenase 1 (Fragments) OS=Catharanthus roseus OX=4058 PE=1 SV=1 ... A secondary alcohol + NAD+ = a ketone + NADH.. ,p>This subsection of the Function section provides information relevant to ... A primary alcohol + NAD+ = an aldehyde + NADH.. ... alcohol dehydrogenase (NAD) activity Source: UniProtKB-EC. * ...
Coniferyl-alcohol dehydrogenase - Wikipedia
... a coniferyl-alcohol dehydrogenase (EC 1.1.1.194) is an enzyme that catalyzes the chemical reaction coniferyl alcohol + NADP+ ... Mansell RL, Babbel GR, Zenk MH (1976). "Multiple forms and specificity of coniferyl alcohol dehydrogenase from cambial regions ... "Purification and properties of isoenzymes of cinnamyl-alcohol dehydrogenase from soybean-cell-suspension cultures". Eur. J. ... The systematic name of this enzyme class is coniferyl-alcohol:NADP+ oxidoreductase. This enzyme is also called CAD. ...
Mutant alcohol dehydrogenase leads to improved ethanol tolerance in Clostridium thermocellum | PNAS
1994) Purification of acetaldehyde dehydrogenase and alcohol dehydrogenases from Thermoanaerobacter ethanolicus 39E and ... characterization of the secondary-alcohol dehydrogenase (2 degrees Adh) as a bifunctional alcohol dehydrogenase-acetyl-CoA ... Mutant alcohol dehydrogenase leads to improved ethanol tolerance in Clostridium thermocellum. Steven D. Brown, Adam M. Guss, ... Mutant alcohol dehydrogenase leads to improved ethanol tolerance in Clostridium thermocellum. Steven D. Brown, Adam M. Guss, ...
RCSB PDB - 2EIH: Crystal Structure of NAD-dependent alcohol dehydrogenase
HADH - Horse Liver Alcohol Dehydrogenase | AcronymFinder
HADH stands for Horse Liver Alcohol Dehydrogenase. HADH is defined as Horse Liver Alcohol Dehydrogenase rarely. ... The kinetics of the compound of horse liver alcohol dehydrogenase and reduced diphosphopyridine nucleotide. ... www.acronymfinder.com/Horse-Liver-Alcohol-Dehydrogenase-(HADH).html. *Chicago style: Acronym Finder. S.v. "HADH." Retrieved ... www.acronymfinder.com/Horse-Liver-Alcohol-Dehydrogenase-(HADH).html,HADH,/a,. ...
4DXH: Horse Liver Alcohol Dehydrogenase Complexed With Nad+ And 2,2,2- Trifluoroethanol
Cross-reactive monoclonal antibodies to alcohol dehydrogenases | SpringerLink
Alcohol dehydrogenase 1A - Saara hardwickii (Indian spiny-tailed lizard)
Alcohol dehydrogenase 1AAdd BLAST. 375. Amino acid modifications. Feature key. Position(s). DescriptionActions. Graphical view ... "Linking of isozyme and class variability patterns in the emergence of novel alcohol dehydrogenase functions. Characterization ... Belongs to the zinc-containing alcohol dehydrogenase family. Class-I subfamily.Curated ... sp,P25405,ADH1A_SAAHA Alcohol dehydrogenase 1A OS=Saara hardwickii OX=40250 PE=1 SV=2 ...
Anti-Alcohol Dehydrogenase 2 Antibody Products | Biocompare
RCSB PDB - Protein Feature View
- NAD-dependent alcohol dehydrogenase - Q9Y9P9 (Q9Y9P9 AERPE)
The PDB archive contains information about experimentally-determined structures of proteins, nucleic acids, and complex assemblies. As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists.
Isolation of Alcohol Dehydrogenase cDNA and Basal Regulatory Region from Metroxylon sagu
... specific motifs such as the two zinc-binding domains that bind to the adenosine ribose of the coenzyme and binding to alcohol ... Alcohol dehydrogenase (Adh) is a versatile enzyme involved in many biochemical pathways in plants such as in germination and ... "Characteristics of alcohol/polyol dehydrogenases. The zinc-containing long-chain alcohol dehydrogenases," European Journal of ... Isolation of Alcohol Dehydrogenase cDNA and Basal Regulatory Region from Metroxylon sagu,. International Scholarly Research ...
Pharmaceutics | Free Full-Text | Encapsulation of Alcohol Dehydrogenase in Mannitol by Spray Drying
The retention of the enzyme activity of alcohol dehydrogenase (ADH) has been studied in various drying processes such as spray ... Keywords: alcohol dehydrogenase; encapsulation; spray drying; mannitol alcohol dehydrogenase; encapsulation; spray drying; ... Shiga, H.; Joreau, H.; Neoh, T.L.; Furuta, T.; Yoshii, H. Encapsulation of Alcohol Dehydrogenase in Mannitol by Spray Drying. ... Encapsulation of Alcohol Dehydrogenase in Mannitol by Spray Drying. Hirokazu Shiga 1. ...
alcohol dehydrogenase 7 Proteins: Novus Biologicals
Browse our alcohol dehydrogenase 7 Protein catalog backed by our Guarantee+. ... alcohol dehydrogenase 7 Proteins. We offer alcohol dehydrogenase 7 Peptides and alcohol dehydrogenase 7 Proteins for use in ... alcohol dehydrogenase VII protein, alcohol dehydrogenase-7 protein, class IV sigma-1 alcohol dehydrogenase protein, class IV ... Gastric alcohol dehydrogenase protein, Retinol dehydrogenase protein. 3 Results for "alcohol-dehydrogenase-7" in Peptides and ...
alcohol dehydrogenase 5 Proteins: Novus Biologicals
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Biomatik CorporationHuman Alcohol Dehydrogenase 2 (ADH2) ELISA Kit, 96
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Shop a large selection of products and learn more about Biomatik CorporationHuman Alcohol Dehydrogenase 2 (ADH2) ELISA Kit, 96 ... The Human Alcohol Dehydrogenase 2 (ADH2) ELISA Kit allows for quantitative determination of Alcohol Dehydrogenase 2 in Serum, ... Cross Activity: No significant cross-reactivity or interference between Alcohol Dehydrogenase 2 and analogues was observed. ...
Computational studies of human class V alcohol dehydrogenase - the odd sibling
... Östberg, Linus J. Karolinska Inst, Sci Life Lab ... Background: All known attempts to isolate and characterize mammalian class V alcohol dehydrogenase (class V ADH), a member of ... Alcohol dehydrogenase, Mutational pressure, Pseudoenzyme, Sequence analysis, Structural calculations National Category Medical ...
Anti-Alcohol Dehydrogenase antibody (HRP) - Azide free (ab34575) References
Alcohol dehydrogenase | definition of alcohol dehydrogenase by Medical dictionary
What is alcohol dehydrogenase? Meaning of alcohol dehydrogenase medical term. What does alcohol dehydrogenase mean? ... Looking for online definition of alcohol dehydrogenase in the Medical Dictionary? alcohol dehydrogenase explanation free. ... See also: alcohol dehydrogenase (acceptor), alcohol dehydrogenase (NADP+). alcohol dehydrogenase. /al·co·hol de·hy·dro·gen·ase ... alcohol dehydrogenase. Also found in: Dictionary, Acronyms, Encyclopedia, Wikipedia.. Related to alcohol dehydrogenase: ...
HPLC-CD selectivity assay for alcohol dehydrogenases - Hamzic - 2011 - Chirality - Wiley Online Library
Furaldehyde substrate specificity and kinetics of Saccharomyces cerevisiae alcohol dehydrogenase 1 variants
Alcohol dehydrogenase molecule - Stock Image C035/5378 - Science Photo Library
Alcohol dehydrogenase (ADH) is an enzyme that facilitates the breakdown of alcohols in the body, which could otherwise be toxic ... Computer model showing the structure of human beta3 alcohol dehydrogenase (magenta, blue) with nicotinamide-adenine- ... Caption: Human alcohol dehydrogenase molecule. Computer model showing the structure of human beta3 alcohol dehydrogenase ( ... Alcohol dehydrogenase (ADH) is an enzyme that facilitates the breakdown of alcohols in the body, which could otherwise be toxic ...
WikiGenes - PP 3839 - alcohol dehydrogenase
Sequence of the gene for a NAD(P)-dependent formaldehyde dehydrogenase (class III alcohol dehydrogenase) from a marine ... Electron transfer from quinohemoprotein alcohol dehydrogenase to blue copper protein azurin in the alcohol oxidase respiratory ... Formaldehyde dehydrogenase from Pseudomonas putida (PFDH) is a member of the zinc-containing medium-chain alcohol dehydrogenase ... We were unable to measure appreciable levels of NAD(P)-dependent formaldehyde dehydrogenases or alcohol dehydrogenase ...
aldehyde-alcohol dehydrogenase (AdhE) | Applied and Environmental Microbiology
Alcohol dehydrogenase class 4 mu/sigma chain - DrugBank
Induction by ethanol of alcohol dehydrogenase activity in Acetobacter pasteurianus. | Journal of Bacteriology
Induction by ethanol of alcohol dehydrogenase activity in Acetobacter pasteurianus.. H Takemura, K Kondo, S Horinouchi, T Beppu ... Induction by ethanol of alcohol dehydrogenase activity in Acetobacter pasteurianus.. H Takemura, K Kondo, S Horinouchi, T Beppu ... Induction by ethanol of alcohol dehydrogenase activity in Acetobacter pasteurianus.. H Takemura, K Kondo, S Horinouchi, T Beppu ... The membrane-bound alcohol dehydrogenase (ADH) activity of Acetobacter pasteurianus NCI1380 was enhanced more than 10-fold by ...
Alcohol dehydrogenase, molecular model - Stock Image - A605/0212 - Science Photo Library
Alcohol dehydrogenase (ADH) is an enzyme that facilitates the break-down of alcohols in the body, which could otherwise be ... Alcohol dehydrogenase, molecular model. Alcohol dehydrogenase (ADH) is an enzyme that facilitates the break-down of alcohols in ... The alcohol is converted to acetaldehyde, an even more toxic molecule, which is then quickly converted into acetate and other ...
Recombinant Anti-Alcohol Dehydrogenase antibody [EPR4439] - BSA and Azide free (ab247607)
Rabbit recombinant monoclonal Alcohol Dehydrogenase antibody [EPR4439] - BSA and Azide free. Validated in WB, IHC, ICC/IF and ... Anti-Alcohol Dehydrogenase antibody [EPR4439] - BSA and Azide free. See all Alcohol Dehydrogenase primary antibodies. ... Primary - Rabbit Anti-Alcohol Dehydrogenase antibody [EPR4439] - BSA and Azide free (ab247607) ICC/IF, WB, IHC-P ... Synthetic peptide within Human Alcohol Dehydrogenase aa 1-100. The exact sequence is proprietary. ...
GeneEthanolHorse liver alcohol dehydCharacterizationOxidoreductaseCDNAAdhEAbstractLiverADH1EnzymesOxidoreductasesSubunitProteinDrosophilaAldehyde dehydrogenasesAlleleSorbitol dehydrogenaseADH2NADHGlutathione-dependent formaldehyde dehydrogenaseGlucose dehydrogenaseMetabolismMolecularAlcoholsGenesGastricSaccharomycesConiferyl alcohol dehydGlobal Alcohol DehydrogenaseSinapyl alcohol dehydrogenaseCinnamyl alcohol dehydrogenasesYeastActivityGeneticsADH3ADH1BZincBenzyl alcoholProteinsADH7NADPEnzymologyClass I alcoholHuman
Gene32
- In humans, sequencing of the ADH1B gene (responsible for production of an alcohol dehydrogenase polypeptide) shows several functional variants. (wikipedia.org)
- Here, we resequence the genome of an ethanol-tolerant mutant, show that the tolerant phenotype is primarily due to a mutated bifunctional acetaldehyde-CoA/alcohol dehydrogenase gene ( adhE ), hypothesize based on structural analysis that cofactor specificity may be affected, and confirm this hypothesis using enzyme assays. (pnas.org)
- In order to elucidate the mechanism of the ethanol induction, a gene cluster encoding the dehydrogenase and cytochrome c subunits of ADH was cloned from this strain, and its nucleotide sequence was determined. (asm.org)
- Transcriptional analysis of the cloned genes by primer extension revealed that the gene cluster was transcribed from two different promoters upstream from the dehydrogenase gene. (asm.org)
- A new study looks at the effects of interplay between peer drinking and the functional variant rs1229984 in the alcohol dehydrogenase 1B gene (ADH1B) among adolescents. (eurekalert.org)
- A study of the interplay between peer drinking and the functional polymorphism rs1229984 in the alcohol dehydrogenase 1B gene (ADH1B) in the development of adolescent drinking milestones has found that peer drinking reduces the protective effects of an ADH1B variant. (eurekalert.org)
- For example, some people have a particular variant of the ADH1B gene that causes an amino acid change in this enzyme, which leads to faster enzyme activity so individuals with this variant metabolize alcohol more rapidly which means that acetaldehyde levels are temporarily increased. (eurekalert.org)
- Molecular and functional characterization of novel glycerol-3-phosphate dehydrogenase 1 like gene (GPD1-L) mutations in sudden infant death syndrome. (harvard.edu)
- Yasunami M, Chen CS, Yoshida A: A human alcohol dehydrogenase gene (ADH6) encoding an additional class of isozyme. (hmdb.ca)
- Polymorphism of the human alcohol dehydrogenase 4 (ADH4) promoter affects gene expression. (thefreedictionary.com)
- Hines' group studied the influence of the gene that encodes alcohol dehydrogenase 3. (thefreedictionary.com)
- Heterologous expression of the Thermoanaerobacter pseudethanolicus 39E bdhA gene, that encodes an alcohol dehydrogenase, in Clostridium thermocellum significantly increased resistance to furan derivatives at concentrations found in acid-pretreated biomass. (osti.gov)
- The gene encoding a novel short-chain alcohol dehydrogenase in the thermophilic bacterium, Carboxydothermus hydrogenoformans, was identified and overexpressed in Escherichia coli. (sigmaaldrich.com)
- This gene encodes class I alcohol dehydrogenase, alpha subunit, which is a member of the alcohol dehydrogenase family. (acris-antibodies.com)
- The aim of this study is to resolve effects of Si on formation of microstructure and regulation of cinnamyl alcohol dehydrogenase (CAD), a key gene responsible for lignin biosynthesis. (frontiersin.org)
- Sequence analysis revealed that this gene encodes a pyrrolo-quinoline quinone-dependent alcohol dehydrogenase (ADH). (apsnet.org)
- Hyun Park, Gene Kidman and Dexter B. Northrop, " Effects of Trehalose on Pressure-Induced Inactivation of Yeast Alcohol Dehydrogenase", Protein & Peptide Letters (2005) 12: 597. (eurekaselect.com)
- We analyzed effects of single nucleotide polymorphisms (SNP) in the alcohol dehyrdogenase gene cluster (ADH1) and interactions with alcohol consumption in relation to GC risk in a case-control study nested in the EPIC cohort (EurGast). (aacrjournals.org)
- The gene encoding an alcohol dehydrogenase from T. hypogea was cloned, sequenced and over-expressed. (uwaterloo.ca)
- Holmes, R. S., 1977, The genetics of a-hydroxyacid oxidase and alcohol dehydrogenase in the mouse: evidence for multiple gene loci and linkage between Hao-2 and Adh-3, Genetics 87:709. (springer.com)
- Holmes, R. S., 1979a, Genetics and ontogeny of alcohol dehydrogenase isozymes in the mouse - evidence for a cis-acting regulator gene (Adh-3-t) controlling C 2 isozyme expression in reproductive tissues and close linkage of Adh-3 and Adh-3-t on chromosome 3, Biochem. (springer.com)
- The ABA2 gene product belongs to the family of short-chain dehydrogenases/reductases, which are known to be NAD- or NADP-dependent oxidoreductases. (plantcell.org)
- Isolation and DNA sequence of ADH3, a nuclear gene encoding the mitochondrial isozyme of alcohol dehydrogenase in Saccharomyces cerevisiae. (asm.org)
- The Saccharomyces cerevisiae nuclear gene, ADH3, that encodes the mitochondrial alcohol dehydrogenase isozyme ADH III was cloned by virtue of its nucleotide homology to ADH1 and ADH2. (asm.org)
- A Nonsense Mutation in a Cinnamyl Alcohol Dehydrogenase Gene Is Respon" by Scott E. Sattler, Aaron J. Saathoff et al. (unl.edu)
- A gene on chromosome 4q23 that encodes a member of the alcohol dehydrogenase family, which metabolise various substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids and lipid peroxidation products. (thefreedictionary.com)
- The class IV alcohol dehydrogenase gene ADH7 encodes an enzyme that is involved in ethanol and retinol metabolism. (iupui.edu)
- Yankovsky, N. 2005-12-14 00:00:00 Frequencies of alleles and genotypes for alcohol dehydrogenase gene ADH1B (arg47his polymorphism), associated with alcohol tolerance/sensitivity, were determined. (deepdyve.com)
- This result gives a third type of evidence, based on purifications and enzyme characterization in lower vertebrates, that the classical liver alcohol dehydrogenase originated by a gene duplication early in the evolution of vertebrates. (diva-portal.org)
- Murtha, MT & Cavener, DR 1989, ' Ecdysteroid regulation of glucose dehydrogenase and alcohol dehydrogenase gene expression in Drosophila melanogaster ', Developmental biology , vol. 135, no. 1, pp. 66-73. (elsevier.com)
- A gene encoding a cinnamyl alcohol dehydrogenase homolog in Arabidopsis thaliana. (edu.au)
- Somers D.A., Nourse J.P., Manners J.M., Abrahams S. and Watson J.M. (1995) A gene encoding a cinnamyl alcohol dehydrogenase homolog in Arabidopsis thaliana. (edu.au)
Ethanol22
- The metabolism of ethanol by gastrointestinal ADH isozymes results in the production of acetaldehyde, a highly toxic compound that binds to cellular protein and DNA if not further metabolized to acetate by acetaldehyde dehydrogenase isozymes. (nih.gov)
- The metabolism of retinol and the generation of retinoic acid is a function of class I and class IV ADH, and its inhibition by alcohol may lead to an alteration of epithelial cell differentiation and cell growth and may also be involved in ethanol-associated gastrointestinal cocarcinogenesis. (nih.gov)
- ADH3 (identical to glutathione-dependent formaldehyde dehydrogenase) is clearly the ancestral ADH form and S-hydroxymethylglutathione is the main physiological substrate, but the enzyme can still oxidize ethanol at high concentrations. (springer.com)
- Cronholm T. Effect of ethanol on the redox state of the coenzyme bound to alcohol dehydrogenase studied in isolated hepatocytes. (springer.com)
- Induction by ethanol of alcohol dehydrogenase activity in Acetobacter pasteurianus. (asm.org)
- The membrane-bound alcohol dehydrogenase (ADH) activity of Acetobacter pasteurianus NCI1380 was enhanced more than 10-fold by the addition of ethanol to the medium. (asm.org)
- Immunoblot analyses showed that almost the same amounts of the cytochrome c and the 15-kDa subunits were produced in both the presence and absence of ethanol and that the amount of the dehydrogenase subunit localized in the membrane was decreased in the absence of ethanol. (asm.org)
- This incorrect localization of the dehydrogenase subunit might be one of the factors responsible for the low ADH activity in the absence of ethanol. (asm.org)
- Other names in common use include primary alcohol dehydrogenase, MDH, quinohemoprotein alcohol dehydrogenase, quinoprotein alcohol dehydrogenase, quinoprotein ethanol dehydrogenase, and alcohol:(acceptor) oxidoreductase. (morebooks.de)
- Narezode (6-methylpyrazole) is a known competitive inhibitor of alcohol dehydrogenase (12-14) that could substitute for ethanol in the treatment of EG poisoning. (thefreedictionary.com)
- Today, humans rely on an enzyme called alcohol dehydrogenase 4, or ADH4, to break down ethanol. (thefreedictionary.com)
- We have developed a recombinant hepatic cell line stably transfected with murine alcohol dehydrogenase cDNA to serve as an in vitro model to investigate these ethanol-induced impairments. (hindawi.com)
- These results indicate that the ethanol-induced impairment in endocytosis is exacerbated by the inhibition of aldehyde dehydrogenase, suggesting the involvement of acetaldehyde in this dysfunction. (hindawi.com)
- Class I alcohol dehydrogenase, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibits high activity for ethanol oxidation and plays a major role in ethanol catabolism. (acris-antibodies.com)
- Kinetic studies of yeast alcohol dehydrogenase with NAD+ and ethanol, hexanol or decanol as substrates invariably result in non-linear Lineweaver-Burk plots if the alcohol is the variable substrate. (thebiogrid.org)
- Effects of castration and chronic morphine administration on liver alcohol dehydrogenase and the metabolism of ethanol in the male Sprague-Dawley rat. (aspetjournals.org)
- The effects of castration on liver alcohol dehydrogenase (ADH) activity and the in vivo metabolism of ethanol were examined in the male Sprague-Dawley-derived rat. (aspetjournals.org)
- The optimal pHs for ethanol oxidation and acetaldehyde reduction were 10.5 and 7.5 respectively, while the activity for alcohol oxidation was much higher than that of aldehyde reduction. (uwaterloo.ca)
- The optimal pHs for ethanol oxidation and acetaldehyde reduction were 11.0 and 8.0 respectively, while activity for alcohol oxidation were higher than that of aldehyde reduction. (uwaterloo.ca)
- This study aims to evaluate the effect of ADH1B and ADH7 genotypes on blood acetaldehyde and ethanol levels after alcohol ingestion, and to measure the genotoxic effect of smoking and ethanol on the buccal cells, also controlling for ADH variants. (separationsnow.com)
- NADP-dependent isopropanol dehydrogenase belongs to the superfamily of alcohol dehydrogenases with a preference for medium chain secondary alcohols, such as 2- butanol and isopropanol, while it has low activity with primary alcohols, such as ethanol. (creative-enzymes.com)
- Immunoblot analysis showed that ADH I is detected in cells grown on each alcohol tested, but ethanol was the most effective inducer. (alpfmedical.info)
Horse liver alcohol dehyd4
- Three-dimensional structure of horse liver alcohol dehydrogenase at 2.4 Å resolution. (springer.com)
- The kinetics of the compound of horse liver alcohol dehydrogenase and reduced diphosphopyridine nucleotide. (acronymfinder.com)
- Three anti-horse liver alcohol dehydrogenase (HLADH) monoclonal antibodies are described. (springer.com)
- The role of arginyl residues in directing carboxymethylation of horse liver alcohol dehydrogenase. (harvard.edu)
Characterization7
- Analysis of rat cytosolic 9-cis-retinol dehydrogenase activity and enzymatic characterization of rat ADHII. (springer.com)
- Functional characterization of SlscADH1, a fruit-ripening-associated short-chain alcohol dehydrogenase of tomato. (sigmaaldrich.com)
- Purification and characterization of human liver sorbitol dehydrogenase. (harvard.edu)
- Biocatalytic characterization of a short-chain alcohol dehydrogenase with broad substrate specificity from thermophilic Carboxydothermus hydrogenoformans. (sigmaaldrich.com)
- Human liver alcohol dehydrogenase: purification and kinetic characterization of the beta 2 beta 2, beta 2 beta 1, alpha beta 2, and beta 2 gamma 1 "Oriental" isoenzymes. (reactome.org)
- Purification and characterization of a novel NADP-dependent branched-chain alcohol dehydrogenase from Saccharomyces cerevisiae. (asm.org)
- We report here the molecular cloning and characterization of the corresponding cDNA, CAD 1-5, which encodes this novel aromatic alcohol dehydrogenase. (deepdyve.com)
Oxidoreductase3
- The systematic name of this enzyme class is coniferyl-alcohol:NADP+ oxidoreductase. (wikipedia.org)
- alcohol:NAD+ oxidoreductase, EC 1.1.1.1). (caltech.edu)
- alcohol:NAD+ oxidoreductase, EC 1.1.1.1) locus in members of the grass family is analyzed. (mysciencework.com)
CDNA3
- Hoog JO, von Bahr-Lindstrom H, Heden LO, Holmquist B, Larsson K, Hempel J, Vallee BL, Jornvall H: Structure of the class II enzyme of human liver alcohol dehydrogenase: combined cDNA and protein sequence determination of the pi subunit. (hmdb.ca)
- Ikuta T, Szeto S, Yoshida A: Three human alcohol dehydrogenase subunits: cDNA structure and molecular and evolutionary divergence. (hmdb.ca)
- The expression system was obtained by ligation of a cDNA fragment corresponding to the fl-subunit of human liver alcohol dehydrogenase into the vector pKK 223-3 containing the tac promoter. (portlandpress.com)
AdhE2
- In the course of engineering these strains, a number of mutations have been discovered in their adhE genes, which encode both alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) enzymes. (asm.org)
- L2 also possess an alcohol dehydrogenase E (ADHE) that makes them unique among hydrogenosome-bearing anaerobes. (nih.gov)
Abstract1
- article{d0bd3d3e-39d7-4ff8-8414-d6b625dafbb7, abstract = {Biosensors for measurement of glycerol in FIA were constructed using NAD(+)-dependent glycerol dehydrogenase (GlDH) either co-immobilized with phenazine methosulphate (PMS) or cross-linked to an Os-complex-modified poly(vinylimidazole) redox polymer (PVI(13)dmeOs) using poly(ethyleneglycole) diglycidilether (PEGDGE). (lu.se)
Liver8
- Isolation of Π-alcohol dehydrogenase of human liver: Is it a determinant of alcoholism? (springer.com)
- Marschall H-U, Opperman UCT, Svensson S, Nordling E, Persson B, Höög J-O, Jörnvall H. Human liver class I alcohol dehydrogenase γγ isozyme: The sole cytosolic 3β-hydroxysteroid dehydrogenase of iso-bile acids. (springer.com)
- The key enzymes involved in alcohol metabolism in the liver are alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH). (thefreedictionary.com)
- Here we report two 1 A resolution crystal structures of liver alcohol dehydrogenase in complex with NADH and two inhibitors: dimethyl sulfoxide and isobutyramide. (lu.se)
- Human liver alcohol dehydrogenase: purification, composition, and catalytic features. (reactome.org)
- Ahd-1 (encoding AHD-A 2 ) was found on chromosome 4 near Gpd-1 (encoding the liver isozyme of glucose-6-phosphate dehydrogenase), whereas the aldehyde oxidase loci (Aox-1, Aox-2) were closely linked on chromosome 1 near Id-1 (encoding isocitrate dehydrogenase). (springer.com)
- The results allow conclusions about the structural and evolutionary relationships within the large family of MDR alcohol dehydrogenases from characterizations of the pigeon (Columba livia) and dogfish (Scyliorhinus canicula) major liver alcohol dehydrogenases. (diva-portal.org)
- After adjustment for age, daily alcohol consumption and amount of cigarette smoking, significantly increased risks (odds ratios) in the presence of the ALDH2 *2 allele were found for oropharyngolaryngeal (11.14), esophageal (12.50), stomach (3.49), colon (3.35), lung (8.20) and esophageal cancer concomitant with oropharyngolaryngeal and/or stomach cancer (54.20) but not for liver or other cancers. (oup.com)
ADH15
- Mammalian alcohol dehydrogenase (ADH) constitutes a complex system with different forms and extensive multiplicity (ADH1-ADH6) that catalyze the oxidation and reduction of a wide variety of alcohols and aldehydes. (springer.com)
- In analyses of interactions between ADH1 locus SNPs and baseline alcohol consumption, we observed a statistically significant interaction between rs1230025 and beer consumption in relation to GC risk (P value=0.003): variant homozygotes were associated with GC in beer consumers (OR=8.58, 95%CI=3.35-22.0), but not in non-consumers (OR=1.21, 95%CI=0.64-2.30). (aacrjournals.org)
- Conclusions: Our results suggest that individuals who are heavy consumers of alcohol (specifically beer) and those with certain alleles in the ADH1 locus, and their combination, are at a greater risk for non-cardia gastric adenocarcinoma. (aacrjournals.org)
- In conclusion, genetic variants at ADH1 and ALDH2 loci may influence GC risk, and alcohol intake may further modify the effect of ADH1 rs1230025. (environment-health.ac.uk)
- Studies on the properties of the human alcohol dehydrogenase isozymes determined by the different loci ADH1, ADH2, ADH3. (escholarship.org)
Enzymes7
- Alcohol dehydrogenases (ADH) (EC 1.1.1.1) are a group of dehydrogenase enzymes that occur in many organisms and facilitate the interconversion between alcohols and aldehydes or ketones with the reduction of nicotinamide adenine dinucleotide (NAD+) to NADH. (wikipedia.org)
- The most robust result to emerge from these studies was the demonstration that the genes involved in alcohol metabolism--that is, genes encoding the alcohol dehydrogenase and aldehyde dehydrogenase enzymes--play important roles in the risk for alcoholism (for more information, see the article by Hurley and Edenberg, pp. (thefreedictionary.com)
- The data presented here can yield a better understanding of alcohol dehydrogenases lacking the catalytic zinc as well as the structural features inherent to thermostable enzymes. (ku.edu)
- Creative Enzymes is one of the few companies in the world that provides spectrophotometric assays for allyl-alcohol dehydrogenase. (biocatalogue.org)
- With specialized knowledge in oxidoreductases, especially the ones such as allyl-alcohol dehydrogenase, Creative Enzymes successfully demonstrated the first-in-class test quality and service reliability. (biocatalogue.org)
- The first step of RA synthesis is controlled by enzymes of the alcohol dehydrogenase (ADH) and retinol dehydrogenase (RDH) families that catalyze oxidation of retinol to retinaldehyde. (ozgene.com)
- Both of these enzymes contain heme c in addition to PQQ and function as quinohemoprotein dehydrogenases. (alpfmedical.info)
Oxidoreductases1
- Persson B, Zigler JS Jr, Jörnvall H. A superfamily of medium-chain dehydrogenases/reductases (MDR): Sub-lines including ζ-crystallin, alcohol and polyol dehydrogenases, quinone oxidoreductases, enoyl reductases, VAT-1 and other proteins. (springer.com)
Subunit2
- ADH1A is class I alcohol dehydrogenase, alpha subunit, which is a member of the alcohol dehydrogenase family. (acris-antibodies.com)
- Altered expression of four proteins, including NADH dehydrogenase flavoprotein 2 (NDUFV2), glyoxalase 1 (GLO1), proteasome subunit beta type 4 (PSMB4, or β7 subunit of proteasome) and nitrilase family, member 2 (Nit2) have been observed between Tg mAPP/DN-RAGE mice cortex and Tg mAPP mice cortex. (bl.uk)
Protein4
- We offer alcohol dehydrogenase 7 Peptides and alcohol dehydrogenase 7 Proteins for use in common research applications: ELISA, Protein Array, Western Blot. (novusbio.com)
- Each alcohol dehydrogenase 7 Peptide and alcohol dehydrogenase 7 Protein is fully covered by our Guarantee+, to give you complete peace of mind and the support when you need it. (novusbio.com)
- Background: All known attempts to isolate and characterize mammalian class V alcohol dehydrogenase (class V ADH), a member of the large ADH protein family, at the protein level have failed. (diva-portal.org)
- The SlscADH1 recombinant protein produced in Escherichia coli exhibited dehydrogenase-reductase activity towards several volatile compounds present in tomato flavour with a strong preference for the NAD/NADH co-factors. (sigmaaldrich.com)
Drosophila3
- Physiological significance of the alcohol dehydrogenase polymorphism in larvae of Drosophila. (thefreedictionary.com)
- Here we use Drosophila melanogaster alcohol dehydrogenase (ADH) in an experimental test for selective differences between these two mechanisms. (genetics.org)
- The temporal patterns of glucose dehydrogenase (Gld) and alcohol dehydrogenase (Adh) expression in Drosophila are correlated positively and negatively, respectively, with ecdysterone titers during the late third instar. (elsevier.com)
Aldehyde dehydrogenases2
- Four additional variants of alcohol and aldehyde dehydrogenases have been purified and functionally characterized, and their primary structures have been determined. (diva-portal.org)
- Alcohol and aldehyde dehydrogenases: Retinoid metabolic effects in mouse knockout models. (ozgene.com)
Allele3
- Those with the variant allele have little tolerance for alcohol, thus lowering chance of dependence and abuse. (wikipedia.org)
- Alcohol dehydrogenase F allele frequencies Accelerated Control Parental Accelerated p = 1. (thefreedictionary.com)
- Genetic polymorphism of alcohol dehydrogenase in Europeans: The ADH2*2 allele decreases the risk for alcoholism and is associated with ADH3*1. (thefreedictionary.com)
Sorbitol dehydrogenase1
- Called also sorbitol dehydrogenase, SDH. (thefreedictionary.com)
ADH23
- The Human Alcohol Dehydrogenase 2 (ADH2) ELISA Kit allows for quantitative determination of Alcohol Dehydrogenase 2 in Serum, Plasma, Tissue homogenates and other biological fluids. (fishersci.com)
- The authors examined the association of the alcohol dehydrogenase 2 (ADH2) genotype with vascular events in community-dwelling Japanese (1,102 men/1,093 women). (neurology.org)
- Enzymatic synthesis of enantiopure aromatic secondary alcohols (including substituted, heteroaromatic and bicyclic structures) were carried out using the halophilic alcohol dehydrogenase ADH2 from Haloferax volcanii (HvADH2). (nottingham.ac.uk)
NADH5
- A primary alcohol + NAD + = an aldehyde + NADH. (uniprot.org)
- A secondary alcohol + NAD + = a ketone + NADH. (uniprot.org)
- A previously discovered mutant of Saccharomyces cerevisiae alcohol dehydrogenase 1 (Adh1p) was shown to enable a unique NADH-dependent reduction of 5-hydroxymethylfurfural (HMF), a well-known inhibitor of yeast fermentation. (diva-portal.org)
- In alcoholic fermentation, it catalyzes the final step of reducing an aldehyde to an alcohol in the presence of NADH and hydrogen. (umassmed.edu)
- We have determined the X-ray crystal structures of the NADH-dependent alcohol dehydrogenase LlAdhA from Lactococcus lactis and its laboratory-evolved variant LlAdhA^(RE1) at 1.9 Å and 2.5 Å resolution, respectively. (caltech.edu)
Glutathione-dependent formaldehyde dehydrogenase1
- Genetic evidence from comparisons of multiple organisms showed that a glutathione-dependent formaldehyde dehydrogenase, identical to a class III alcohol dehydrogenase (ADH-3/ADH5), is presumed to be the ancestral enzyme for the entire ADH family. (wikipedia.org)
Glucose dehydrogenase1
- In this study, a novel biocatalyst consisting of magnetic combined cross-linked enzyme aggregates (combi-CLEAs) of 3-quinuclidinone reductase (QNR) and glucose dehydrogenase (GDH) for enantioselective synthesis of ( R )-3-quinuclidinolwith regeneration of cofactors in situ was developed. (mdpi.com)
Metabolism3
- the role of decreased gastric alcohol dehydrogenase and first pass metabolism. (thefreedictionary.com)
- Metabolism and pharmacokinetics of 3-n-butylphthalide (NBP) in humans: the role of cytochrome P450s and alcohol dehydrogenase in biotransformation. (curehunter.com)
- Aldehyde dehydrogenase-2 (ALDH2) eliminates most of the acetaldehyde produced during alcohol metabolism. (oup.com)
Molecular1
- Molecular evolution of alcohol dehydrogenase 1 in members of t. (mysciencework.com)
Alcohols11
- Alcohol dehydrogenase (ADH) consists of a family of isozymes that convert alcohols to their corresponding aldehydes using NAD+ as a cofactor. (nih.gov)
- In humans and many other animals, they serve to break down alcohols that otherwise are toxic, and they also participate in generation of useful aldehyde, ketone, or alcohol groups during biosynthesis of various metabolites. (wikipedia.org)
- The alcohol dehydrogenases comprise a group of several isozymes that catalyse the oxidation of primary and secondary alcohols to aldehydes and ketones, respectively, and also can catalyse the reverse reaction. (wikipedia.org)
- Alcohol dehydrogenase (ADH) is an enzyme that facilitates the breakdown of alcohols in the body, which could otherwise be toxic. (sciencephoto.com)
- ADH functions primarily in the detoxification of ingested alcohols, and it is thought that the evolution of this enzyme, accompanied by adaptation to survival in alcohol-rich environments such as rotting fruits, has played an important role in the evolution of the family Drosophilidae, particularly the subfamily Drosophilinae ( A shburner 1998 ). (genetics.org)
- Cinnamyl alcohol dehydrogenase is a zinc- and NADPH-dependent dehydrogenase catalyzing the reversible conversion of p-hydroxycinnamaldehydes to their corresponding hydroxycinnamyl alcohols. (unboundmedicine.com)
- Kinetics and reaction mechanism of yeast alcohol dehydrogenase with long-chain primary alcohols. (thebiogrid.org)
- The kinetic coefficients determined from secondary plots are consistent with an 'equilibrium random-order' mechanism for extremely low alcohol concentrations and for all alcohols, the transformation of the ternary complexes being the rate-limiting step of the reaction. (thebiogrid.org)
- Alcohol dehydrogenase (ADH) is a key enzyme responsible for alcohol production, catalyzing interconversions between alcohols and corresponding ketones or aldehydes. (uwaterloo.ca)
- Rising Demand to Produce Pure Stereoisomers of Chiral Alcohols is also expected to contribute significantly to the Alcohol Dehydrogenase market. (advancemarketanalytics.com)
- Alcohol substrates: Seventeen different alcohols were tested. (escholarship.org)
Genes2
- Only a limited number of studies have investigated the interplay between specific robust genes associated with the development of alcohol dependence and environments during the critical developmental period of adolescence," said Bierut. (eurekalert.org)
- Disruption of the genes encoding both cinnamyl alcohol dehydrogenases ( CADs ), including CADC and CADD , in Arabidopsis thaliana results in the atypical incorporation of hydroxycinnamaldehydes into lignin. (plantcell.org)
Gastric3
- In contrast with the report the alcohol dehydrogenase activity in gastric mucosa is lower in women than in men[6], in this small study we noted no significant difference in activities between the sexes. (thefreedictionary.com)
- Genetic variation in alcohol dehydrogenase (ADH1A, ADH1B, ADH1C, ADH7) and aldehyde dehydrogenase (ALDH2), alcohol consumption and gastric cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. (environment-health.ac.uk)
- Studies that have examined the association between alcohol consumption and gastric cancer (GC) risk have been inconsistent. (environment-health.ac.uk)
Saccharomyces2
- The first-ever isolated alcohol dehydrogenase (ADH) was purified in 1937 from Saccharomyces cerevisiae (brewer's yeast). (wikipedia.org)
- An NADP-dependent branched-chain alcohol dehydrogenase was purified from Saccharomyces cerevisiae var. (asm.org)
Coniferyl alcohol dehyd1
- In enzymology, a coniferyl-alcohol dehydrogenase (EC 1.1.1.194) is an enzyme that catalyzes the chemical reaction coniferyl alcohol + NADP+ ⇌ {\displaystyle \rightleftharpoons } coniferyl aldehyde + NADPH + H+ Thus, the two substrates of this enzyme are coniferyl alcohol and NADP+, whereas its 3 products are coniferyl aldehyde, NADPH, and H+. (wikipedia.org)
Global Alcohol Dehydrogenase2
- Along with this, the Global Alcohol Dehydrogenase market size has been validated using both top-down and bottom-up approaches. (advancemarketanalytics.com)
- The Global Alcohol Dehydrogenase market size will be XX million (USD) in 2023, from the XX million (USD) in 2017, with a CAGR (Compound Annual Growth Rate) of XX% from between 2017 and 2023. (reportsnreports.com)
Sinapyl alcohol dehydrogenase1
- The structure of HpCAD is highly homologous to the sinapyl alcohol dehydrogenase and the plant CAD with well-conserved residues involved in catalysis and zinc binding. (unboundmedicine.com)
Cinnamyl alcohol dehydrogenases1
- Enzyme activity and substrate specificity of the major cinnamyl alcohol dehydrogenases in sorghum. (plantphysiol.org)
Yeast4
- In yeast, plants, and many bacteria, some alcohol dehydrogenases catalyze the opposite reaction as part of fermentation to ensure a constant supply of NAD+. (wikipedia.org)
- Though this feature is not adaptive from an energy point of view, by making alcohol in such high concentrations so that they would be toxic to other organisms, yeast cells could effectively eliminate their competition. (wikipedia.org)
- Isozymes of yeast alcohol dehydrogenase are slowly denatured at moderate hydrostatic pressures ( (eurekaselect.com)
- Alcohol dehydrogenase derived from yeast is a metalloenzyme containing four tightly bound zinc atoms per molecule (Vallee and Hoch, Proc. (p212121.com)
Activity4
- The retention of the enzyme activity of alcohol dehydrogenase (ADH) has been studied in various drying processes such as spray drying. (mdpi.com)
- Cross Activity: No significant cross-reactivity or interference between Alcohol Dehydrogenase 2 and analogues was observed. (fishersci.com)
- A CAD homolog from Helicobacter pylori (HpCAD) possesses broad substrate specificities like the plant CADs and additionally a dismutation activity converting benzaldehyde to benzyl alcohol and benzoic acid. (unboundmedicine.com)
- Combining detailed structural information and directed evolution, we have achieved significant improvements in non-native alcohol dehydrogenase activity that will facilitate the production of next-generation fuels such as isobutanol from renewable resources. (caltech.edu)
Genetics2
- Can genetics predict risk for alcohol dependence? (thefreedictionary.com)
- Holmes, R.S., 1978b, Genetics and ontogeny of aldehyde dehydrogenase isozymes in the mouse: localization of Ahd-1 encoding the mitochondrial isozymes on chromosome 4, Biochem. (springer.com)
ADH31
- Expression of alcohol dehydrogenase 3 (ADH3) in tissue and cultured cells from human oral mucosa. (springer.com)
ADH1B4
- Given the toxicity of acetaldehyde, negative effects are experienced by people with this ADH1B variant when they drink alcohol, which discourages heavy drinking and serves as a protective effect. (eurekalert.org)
- Because peer drinking is known to have a strong effect on youth alcohol use, we hypothesized that this important environmental influence would alter the effect of the ADH1B variant on early drinking milestones, such as becoming intoxicated or experiencing a symptom of an AUD. (eurekalert.org)
- Study authors selected 1,550 European and African-American individuals (766 females, 784 males) who had a full drink of alcohol before age 18, since the ADH1B variant is expected to exhibit a protective effect only in response to alcohol consumption. (eurekalert.org)
- A known functional SNP in ADH1B (rs1229984) was associated with alcohol intake (P-value = 0.04) but not GC risk. (environment-health.ac.uk)
Zinc2
- The putative basal msAdh 1 regulatory region was further determined to contain promoter signals of TATA and AGGA boxes and predicted amino acids analyses showed several Adh -specific motifs such as the two zinc-binding domains that bind to the adenosine ribose of the coenzyme and binding to alcohol substrate. (hindawi.com)
- Belongs to the zinc-containing alcohol dehydrogenase family. (abcam.com)
Benzyl alcohol2
- It is highly specific for benzyl alcohol. (mybiosource.com)
- Also known as Aryl-alcohol dehydrogenase (Benzyl alcohol dehydrogenase) (BADH). (mybiosource.com)
Proteins3
- Our alcohol dehydrogenase 7 Peptides and alcohol dehydrogenase 7 Proteins can be used in a variety of model species: Human. (novusbio.com)
- Choose from our alcohol dehydrogenase 7 Peptides and Proteins. (novusbio.com)
- Comparison of the deduced amino acid sequences and the NH2-terminal sequences determined with purified proteins showed that the dehydrogenase and cytochrome c subunits contained typical signal peptides of 35 and 26 amino acids, respectively. (asm.org)
ADH72
- ADH7 and aldehyde dehydrogenase, ALDH2), alcohol intake and GC risk. (environment-health.ac.uk)
- Variants in ADH7 were not associated with alcohol intake or GC risk. (environment-health.ac.uk)
NADP1
- Also known as Aryl-alcohol dehydrogenase [NADP(+)] (AAD). (mybiosource.com)
Enzymology1
- In enzymology, an alcohol dehydrogenase (acceptor) (EC 1.1.99.8) is an enzyme that catalyzes the chemical reaction a primary alcohol + acceptor \rightleftharpoons an aldehyde + reduced acceptor Thus, the two substrates of this enzyme are primary alcohol and acceptor, whereas its two products are aldehyde and reduced acceptor. (morebooks.de)
Class I alcohol1
- Niederhut MS, Gibbons BJ, Perez-Miller S, Hurley TD: Three-dimensional structures of the three human class I alcohol dehydrogenases. (hmdb.ca)
Human5
- Human alcohol dehydrogenase molecule. (sciencephoto.com)
- Computer model showing the structure of human beta3 alcohol dehydrogenase (magenta, blue) with nicotinamide-adenine-dinucleotides shown in green. (sciencephoto.com)
- Synthetic peptide within Human Alcohol Dehydrogenase aa 1-100. (abcam.com)
- Human alcohol dehydrogenase (ADH, tiff isozyme of class I) was expressed in Escherichia coli, purified to homogeneity, and characterized regarding N-terminal processing. (portlandpress.com)
- Using M3-2 and 11-hydroxy-NBP as substrates, human subcellular fractions experiments revealed that P450, alcohol dehydrogenase , and aldehyde dehydrogenase catalyzed the generation of M2 and M5-2. (curehunter.com)