Albuminuria: The presence of albumin in the urine, an indicator of KIDNEY DISEASES.Diabetic Nephropathies: KIDNEY injuries associated with diabetes mellitus and affecting KIDNEY GLOMERULUS; ARTERIOLES; KIDNEY TUBULES; and the interstitium. Clinical signs include persistent PROTEINURIA, from microalbuminuria progressing to ALBUMINURIA of greater than 300 mg/24 h, leading to reduced GLOMERULAR FILTRATION RATE and END-STAGE RENAL DISEASE.Glomerular Filtration Rate: The volume of water filtered out of plasma through glomerular capillary walls into Bowman's capsules per unit of time. It is considered to be equivalent to INULIN clearance.Podocytes: Highly differentiated epithelial cells of the visceral layer of BOWMAN CAPSULE of the KIDNEY. They are composed of a cell body with major CELL SURFACE EXTENSIONS and secondary fingerlike extensions called pedicels. They enwrap the KIDNEY GLOMERULUS capillaries with their cell surface extensions forming a filtration structure. The pedicels of neighboring podocytes interdigitate with each other leaving between them filtration slits that are bridged by an extracellular structure impermeable to large macromolecules called the slit diaphragm, and provide the last barrier to protein loss in the KIDNEY.Kidney Glomerulus: A cluster of convoluted capillaries beginning at each nephric tubule in the kidney and held together by connective tissue.CreatinineDiabetes Mellitus, Type 2: A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.Kidney Diseases: Pathological processes of the KIDNEY or its component tissues.Kidney: Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.Glutamyl Aminopeptidase: A ZINC-dependent membrane-bound aminopeptidase that catalyzes the N-terminal peptide cleavage of GLUTAMATE (and to a lesser extent ASPARTATE). The enzyme appears to play a role in the catabolic pathway of the RENIN-ANGIOTENSIN SYSTEM.Proteinuria: The presence of proteins in the urine, an indicator of KIDNEY DISEASES.Blood Pressure: PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.Renal Insufficiency: Conditions in which the KIDNEYS perform below the normal level in the ability to remove wastes, concentrate URINE, and maintain ELECTROLYTE BALANCE; BLOOD PRESSURE; and CALCIUM metabolism. Renal insufficiency can be classified by the degree of kidney damage (as measured by the level of PROTEINURIA) and reduction in GLOMERULAR FILTRATION RATE.Renal Insufficiency, Chronic: Conditions in which the KIDNEYS perform below the normal level for more than three months. Chronic kidney insufficiency is classified by five stages according to the decline in GLOMERULAR FILTRATION RATE and the degree of kidney damage (as measured by the level of PROTEINURIA). The most severe form is the end-stage renal disease (CHRONIC KIDNEY FAILURE). (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002)Kidney Function Tests: Laboratory tests used to evaluate how well the kidneys are working through examination of blood and urine.Glomerulosclerosis, Focal Segmental: A clinicopathological syndrome or diagnostic term for a type of glomerular injury that has multiple causes, primary or secondary. Clinical features include PROTEINURIA, reduced GLOMERULAR FILTRATION RATE, and EDEMA. Kidney biopsy initially indicates focal segmental glomerular consolidation (hyalinosis) or scarring which can progress to globally sclerotic glomeruli leading to eventual KIDNEY FAILURE.Risk Factors: An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.Hypertension: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.Glomerular Filtration Barrier: A specialized barrier in the kidney, consisting of the fenestrated CAPILLARY ENDOTHELIUM; GLOMERULAR BASEMENT MEMBRANE; and glomerular epithelium (PODOCYTES). The barrier prevents the filtration of PLASMA PROTEINS.Diabetes Mellitus, Experimental: Diabetes mellitus induced experimentally by administration of various diabetogenic agents or by PANCREATECTOMY.Hypertension, Renal: Persistent high BLOOD PRESSURE due to KIDNEY DISEASES, such as those involving the renal parenchyma, the renal vasculature, or tumors that secrete RENIN.Albumins: Water-soluble proteins found in egg whites, blood, lymph, and other tissues and fluids. They coagulate upon heating.Diabetes Mellitus, Type 1: A subtype of DIABETES MELLITUS that is characterized by INSULIN deficiency. It is manifested by the sudden onset of severe HYPERGLYCEMIA, rapid progression to DIABETIC KETOACIDOSIS, and DEATH unless treated with insulin. The disease may occur at any age, but is most common in childhood or adolescence.Kidney Failure, Chronic: The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION.Cross-Sectional Studies: Studies in which the presence or absence of disease or other health-related variables are determined in each member of the study population or in a representative sample at one particular time. This contrasts with LONGITUDINAL STUDIES which are followed over a period of time.Losartan: An antagonist of ANGIOTENSIN TYPE 1 RECEPTOR with antihypertensive activity due to the reduced pressor effect of ANGIOTENSIN II.Indians, North American: Individual members of North American ethnic groups with ancient historic ancestral origins in Asia.Disease Progression: The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.Cardiovascular Diseases: Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.Biological Markers: Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.Antihypertensive Agents: Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS.Glomerulonephritis: Inflammation of the renal glomeruli (KIDNEY GLOMERULUS) that can be classified by the type of glomerular injuries including antibody deposition, complement activation, cellular proliferation, and glomerulosclerosis. These structural and functional abnormalities usually lead to HEMATURIA; PROTEINURIA; HYPERTENSION; and RENAL INSUFFICIENCY.Angiotensin-Converting Enzyme Inhibitors: A class of drugs whose main indications are the treatment of hypertension and heart failure. They exert their hemodynamic effect mainly by inhibiting the renin-angiotensin system. They also modulate sympathetic nervous system activity and increase prostaglandin synthesis. They cause mainly vasodilation and mild natriuresis without affecting heart rate and contractility.Prevalence: The total number of cases of a given disease in a specified population at a designated time. It is differentiated from INCIDENCE, which refers to the number of new cases in the population at a given time.Collagen Type IV: A non-fibrillar collagen found in the structure of BASEMENT MEMBRANE. Collagen type IV molecules assemble to form a sheet-like network which is involved in maintaining the structural integrity of basement membranes. The predominant form of the protein is comprised of two alpha1(IV) subunits and one alpha2(IV) subunit, however, at least six different alpha subunits can be incorporated into the heterotrimer.Angiotensin II Type 1 Receptor Blockers: Agents that antagonize ANGIOTENSIN II TYPE 1 RECEPTOR. Included are ANGIOTENSIN II analogs such as SARALASIN and biphenylimidazoles such as LOSARTAN. Some are used as ANTIHYPERTENSIVE AGENTS.Diabetic Angiopathies: VASCULAR DISEASES that are associated with DIABETES MELLITUS.Fumarates: Compounds based on fumaric acid.Cystatin C: An extracellular cystatin subtype that is abundantly expressed in bodily fluids. It may play a role in the inhibition of interstitial CYSTEINE PROTEASES.Diabetes Complications: Conditions or pathological processes associated with the disease of diabetes mellitus. Due to the impaired control of BLOOD GLUCOSE level in diabetic patients, pathological processes develop in numerous tissues and organs including the EYE, the KIDNEY, the BLOOD VESSELS, and the NERVE TISSUE.Hemoglobin A, Glycosylated: Minor hemoglobin components of human erythrocytes designated A1a, A1b, and A1c. Hemoglobin A1c is most important since its sugar moiety is glucose covalently bound to the terminal amino acid of the beta chain. Since normal glycohemoglobin concentrations exclude marked blood glucose fluctuations over the preceding three to four weeks, the concentration of glycosylated hemoglobin A is a more reliable index of the blood sugar average over a long period of time.Northern Territory: Territory in north central Australia, between the states of Queensland and Western Australia. Its capital is Darwin.Urinalysis: Examination of urine by chemical, physical, or microscopic means. Routine urinalysis usually includes performing chemical screening tests, determining specific gravity, observing any unusual color or odor, screening for bacteriuria, and examining the sediment microscopically.Nephritis: Inflammation of any part of the KIDNEY.Cohort Studies: Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.Oceanic Ancestry Group: Individuals whose ancestral origins are in the islands of the central and South Pacific, including Micronesia, Melanesia, Polynesia, and traditionally Australasia.Enalapril: An angiotensin-converting enzyme inhibitor that is used to treat HYPERTENSION and HEART FAILURE.Nephrosis: Pathological processes of the KIDNEY without inflammatory or neoplastic components. Nephrosis may be a primary disorder or secondary complication of other diseases. It is characterized by the NEPHROTIC SYNDROME indicating the presence of PROTEINURIA and HYPOALBUMINEMIA with accompanying EDEMA.Disease Models, Animal: Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.Diabetes Mellitus: A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.North DakotaProspective Studies: Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.Nephrectomy: Excision of kidney.Follow-Up Studies: Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.TetrazolesAutomobile Driver Examination: Government required written and driving test given to individuals prior to obtaining an operator's license.Glomerular Mesangium: The thin membranous structure supporting the adjoining glomerular capillaries. It is composed of GLOMERULAR MESANGIAL CELLS and their EXTRACELLULAR MATRIX.Chronic Disease: Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care. (Dictionary of Health Services Management, 2d ed)Renin-Angiotensin System: A BLOOD PRESSURE regulating system of interacting components that include RENIN; ANGIOTENSINOGEN; ANGIOTENSIN CONVERTING ENZYME; ANGIOTENSIN I; ANGIOTENSIN II; and angiotensinase. Renin, an enzyme produced in the kidney, acts on angiotensinogen, an alpha-2 globulin produced by the liver, forming ANGIOTENSIN I. Angiotensin-converting enzyme, contained in the lung, acts on angiotensin I in the plasma converting it to ANGIOTENSIN II, an extremely powerful vasoconstrictor. Angiotensin II causes contraction of the arteriolar and renal VASCULAR SMOOTH MUSCLE, leading to retention of salt and water in the KIDNEY and increased arterial blood pressure. In addition, angiotensin II stimulates the release of ALDOSTERONE from the ADRENAL CORTEX, which in turn also increases salt and water retention in the kidney. Angiotensin-converting enzyme also breaks down BRADYKININ, a powerful vasodilator and component of the KALLIKREIN-KININ SYSTEM.Rats, Transgenic: Laboratory rats that have been produced from a genetically manipulated rat EGG or rat EMBRYO, MAMMALIAN. They contain genes from another species.Streptozocin: An antibiotic that is produced by Stretomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.South DakotaMesangial Cells: Smooth muscle-like cells adhering to the wall of the small blood vessels of the KIDNEY at the glomerulus and along the vascular pole of the glomerulus in the JUXTAGLOMERULAR APPARATUS. They are myofibroblasts with contractile and phagocytic properties. These cells and their MESANGIAL EXTRACELLULAR MATRIX constitute the GLOMERULAR MESANGIUM.Animals, Congenic: Animals that are produced through selective breeding to eliminate genetic background differences except for a single or few specific loci. They are used to investigate the contribution of genetic background differences to PHENOTYPE.Nephrotic Syndrome: A condition characterized by severe PROTEINURIA, greater than 3.5 g/day in an average adult. The substantial loss of protein in the urine results in complications such as HYPOPROTEINEMIA; generalized EDEMA; HYPERTENSION; and HYPERLIPIDEMIAS. Diseases associated with nephrotic syndrome generally cause chronic kidney dysfunction.Incidence: The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases, new or old, in the population at a given time.Glycosuria: The appearance of an abnormally large amount of GLUCOSE in the urine, such as more than 500 mg/day in adults. It can be due to HYPERGLYCEMIA or genetic defects in renal reabsorption (RENAL GLYCOSURIA).Aminopeptidases: A subclass of EXOPEPTIDASES that act on the free N terminus end of a polypeptide liberating a single amino acid residue. EC 3.4.11.Ramipril: A long-acting angiotensin-converting enzyme inhibitor. It is a prodrug that is transformed in the liver to its active metabolite ramiprilat.Basement Membrane: A darkly stained mat-like EXTRACELLULAR MATRIX (ECM) that separates cell layers, such as EPITHELIUM from ENDOTHELIUM or a layer of CONNECTIVE TISSUE. The ECM layer that supports an overlying EPITHELIUM or ENDOTHELIUM is called basal lamina. Basement membrane (BM) can be formed by the fusion of either two adjacent basal laminae or a basal lamina with an adjacent reticular lamina of connective tissue. BM, composed mainly of TYPE IV COLLAGEN; glycoprotein LAMININ; and PROTEOGLYCAN, provides barriers as well as channels between interacting cell layers.Antigens, Thy-1: A group of differentiation surface antigens, among the first to be discovered on thymocytes and T-lymphocytes. Originally identified in the mouse, they are also found in other species including humans, and are expressed on brain neurons and other cells.Biphenyl CompoundsUnited StatesPuromycin Aminonucleoside: PUROMYCIN derivative that lacks the methoxyphenylalanyl group on the amine of the sugar ring. It is an antibiotic with antineoplastic properties and can cause nephrosis.

Prevalence of peripheral arterial disease and associated risk factors in American Indians: the Strong Heart Study. (1/2491)

Studies of peripheral arterial disease (PAD) in minority populations provide researchers with an opportunity to evaluate PAD risk factors and disease severity under different types of conditions. Examination 1 of the Strong Heart Study (1989-1992) provided data on the prevalence of PAD and its risk factors in a sample of American Indians. Participants (N = 4,549) represented 13 tribes located in three geographically diverse centers in the Dakotas, Oklahoma, and Arizona. Participants in this epidemiologic study were aged 45-74 years; 60% were women. Using the single criterion of an ankle brachial index less than 0.9 to define PAD, the prevalence of PAD was approximately 5.3% across centers, with women having slightly higher rates than men. Factors significantly associated with PAD in univariate analyses for both men and women included age, systolic blood pressure, hemoglobin A1c level, albuminuria, fibrinogen level, fasting glucose level, prevalence of diabetes mellitus, and duration of diabetes. Multiple logistic regression analyses were used to predict PAD for women and men combined. Age, systolic blood pressure, current cigarette smoking, pack-years of smoking, albuminuria (micro- and macro-), low density lipoprotein cholesterol level, and fibrinogen level were significantly positively associated with PAD. Current alcohol consumption was significantly negatively associated with PAD. In American Indians, the association of albuminuria with PAD may equal or exceed the association of cigarette smoking with PAD.  (+info)

Acute haemodynamic and proteinuric effects of prednisolone in patients with a nephrotic syndrome. (2/2491)

BACKGROUND: Administration of prednisolone causes an abrupt rise in proteinuria in patients with a nephrotic syndrome. METHODS: To clarify the mechanisms responsible for this increase in proteinuria we have performed a placebo controlled study in 26 patients with a nephrotic syndrome. Systemic and renal haemodynamics and urinary protein excretion were measured after prednisolone and after placebo. RESULTS: After i.v. administration of 125-150 mg prednisolone total proteinuria increased from 6.66+/-4.42 to 9.37+/-6.07 mg/min (P<0.001). By analysing the excretion of proteins with different charge and weight (albumin, transferrin, IgG, IgG4 and beta2-microglobulin) it became apparent that the increase of proteinuria was the result of a change in size selectivity rather than a change in glomerular charge selectivity or tubular protein reabsorption. Glomerular filtration rate rose from 83+/-34 ml to 95+/-43 ml/min (P<0.001) after 5 h, whereas effective renal plasma flow and endogenous creatinine clearance remained unchanged. As a result filtration fraction was increased, compatible with an increased glomerular pressure, which probably contributes to the size selectivity changes. Since corticosteroids affect both the renin-angiotensin system and renal prostaglandins, we have evaluated the effects of prednisolone on proteinuria after pretreatment with 3 months of the angiotensin-converting enzyme inhibitor lisinopril or after 2 weeks of the prostaglandin synthesis inhibitor indomethacin. Neither drug had any effect on prednisolone-induced increases of proteinuria. CONCLUSIONS: Prednisolone increases proteinuria by changing the size selective barrier of the glomerular capillary. Neither the renin-angiotensin axis nor prostaglandins seem to be involved in these effects of prednisolone on proteinuria.  (+info)

Increased renal resistive index in patients with essential hypertension: a marker of target organ damage. (3/2491)

BACKGROUND: Increased renal resistance detected by ultrasound (US) Doppler has been reported in severe essential hypertension (EH) and recently was shown to correlate with the degree of renal impairment in hypertensive patients with chronic renal failure. However, the pathophysiological significance of this finding is still controversial. METHODS: In a group of 211 untreated patients with EH, we evaluated renal resistive index (RI) by US Doppler of interlobar arteries and early signs of target organ damage (TOD). Albuminuria was measured as the albumin to creatinine ratio (ACR) in three non-consecutive first morning urine samples. Left ventricular mass was evaluated by M-B mode echocardiography, and carotid wall thickness (IMT) by high resolution US scan. RESULTS: RI was positively correlated with age (r=0.25, P=0.003) and systolic blood pressure (SBP) (r=0.2, P=0.02) and with signs of early TOD, namely ACR (r=0.22, P=0.01) and IMT (r=0.17, P<0.05), and inversely correlated with renal volume (r=-0.22, P=0.01) and diastolic blood pressure (r=-0.23, P=0.006). Multiple linear regression analysis demonstrated that age, gender, ACR and SBP independently influence RI and together account for approximately 20% of its variations (F=8.153, P<0.0001). When clinical data were analysed according to the degree of RI, the patients in the top quartile were found to be older (P<0.05) and with higher SBP (P<0.05) as well as early signs of TOD, namely increased ACR (P<0.002) and IMT (P<0.005 by ANOVA), despite similar body mass index, uric acid, fasting blood glucose, lipid profile and duration of hypertension. Furthermore, patients with higher RI showed a significantly higher prevalence of microalbuminuria (13 vs 12 vs 3 vs 33% chi2=11.72, P=0.008) and left ventricular hypertrophy (40 vs 43 vs 32 vs 60%, chi2=9.25, P<0.05). CONCLUSIONS: Increased RI is associated with early signs of TOD in EH and could be a marker of intrarenal atherosclerosis.  (+info)

Cardiovascular, endocrine, and renal effects of urodilatin in normal humans. (4/2491)

Effects of urodilatin (5, 10, 20, and 40 ng. kg-1. min-1) infused over 2 h on separate study days were studied in eight normal subjects with use of a randomized, double-blind protocol. All doses decreased renal plasma flow (hippurate clearance, 13-37%) and increased fractional Li+ clearance (7-22%) and urinary Na+ excretion (by 30, 76, 136, and 99% at 5, 10, 20, and 40 ng. kg-1. min-1, respectively). Glomerular filtration rate did not increase significantly with any dose. The two lowest doses decreased cardiac output (7 and 16%) and stroke volume (10 and 20%) without changing mean arterial blood pressure and heart rate. The two highest doses elicited larger decreases in stroke volume (17 and 21%) but also decreased blood pressure (6 and 14%) and increased heart rate (15 and 38%), such that cardiac output remained unchanged. Hematocrit and plasma protein concentration increased with the three highest doses. The renin-angiotensin-aldosterone system was inhibited by the three lowest doses but activated by the hypotensive dose of 40 ng. kg-1. min-1. Plasma vasopressin increased by factors of up to 5 during infusion of the three highest doses. Atrial natriuretic peptide immunoreactivity (including urodilatin) and plasma cGMP increased dose dependently. The urinary excretion rate of albumin was elevated up to 15-fold (37 +/- 17 micrograms/min). Use of a newly developed assay revealed that baseline urinary urodilatin excretion rate was low (<10 pg/min) and that fractional excretion of urodilatin remained below 0.1%. The results indicate that even moderately natriuretic doses of urodilatin exert protracted effects on systemic hemodynamic, endocrine, and renal functions, including decreases in cardiac output and renal blood flow, without changes in arterial pressure or glomerular filtration rate, and that filtered urodilatin is almost completely removed by the renal tubules.  (+info)

Microalbuminuria and peripheral arterial disease are independent predictors of cardiovascular and all-cause mortality, especially among hypertensive subjects: five-year follow-up of the Hoorn Study. (5/2491)

Microalbuminuria (MA) is associated with increased cardiovascular and all-cause mortality. It has been proposed that MA reflects generalized atherosclerosis and may thus predict mortality. To investigate this hypothesis, we studied the associations between, on the one hand, MA and peripheral arterial disease (PAD), a generally accepted marker of generalized atherosclerosis, and, on the other hand, cardiovascular and all-cause mortality in an age-, sex-, and glucose tolerance-stratified sample (n=631) of a population-based cohort aged 50 to 75 years followed prospectively for 5 years. At baseline, the albumin-to-creatinine ratio (ACR) was measured in an overnight spot urine sample; MA was defined as ACR >2.0 mg/mmol. PAD was defined as an ankle-brachial pressure index below 0.90 and/or a history of a peripheral arterial bypass or amputation. After 5 years of follow-up, 58 subjects had died (24 of cardiovascular causes). Both MA and PAD were associated with a 4-fold increase in cardiovascular mortality. After adjusting for age, sex, diabetes mellitus, hypertension, levels of total and HDL-cholesterol and triglyceride, body mass index, smoking habits, and preexistent ischemic heart disease, the relative risks (RR) (95% confidence intervals) were 3.2 (1.3 to 8.1) for MA and 2.4 (0.9 to 6.1) for PAD. When both MA and PAD were included in the multivariate analysis, the RRs were 2.9 (1.1 to 7.3) for MA and 2.0 (0.7 to 5.7) for PAD. MA and PAD were both associated with an about 2-fold increase in all-cause mortality. The RRs of all-cause mortality associated with MA and PAD were about 4 times higher among hypertensive than among normotensive subjects. We conclude that both MA and PAD are associated with an increased risk of cardiovascular mortality. MA and PAD are mutually independent risk indicators. The associations of MA and PAD with all-cause mortality are somewhat weaker. They are more pronounced in the presence of hypertension than in its absence. These data suggest that MA affects mortality risk through a mechanism different from generalized atherosclerosis.  (+info)

Chronic bradykinin infusion and receptor blockade in angiotensin II hypertension in rats. (6/2491)

The influence of endogenous bradykinin(BK) on the control of arterial pressure and the development of cardiac hypertrophy was assessed in chronically angiotensin II(Ang II)-infused rats (200 ng. kg-1. min-1) through the effects of concomitant infusion of 3 doses of BK (15 ng. kg-1. d-1, 100 ng. kg-1. d-1 and 100 ng. kg-1. min-1 ie, 144 000 ng. kg-1. d-1) or BK-blockade by Hoe140 (300 microg. kg-1. d-1) for 10 days. In Ang II-infused rats, tail-cuff pressure increased from 124+/-3 to 174+/-6 mm Hg (P<0.001). The pressor effect of Ang II was not affected by simultaneous infusion of BK or Hoe140. At the end of the experiments, cardiac mass was higher in rats infused with Ang II alone (3.56+/-0.10 versus 2.89+/-0.05 mg/g in untreated controls, P<0.01) and the development of cardiac hypertrophy was not modified by administration of the 3 doses of BK or Hoe140. In addition, the fall in cardiac output associated with Ang II was prevented only by the moderate and high doses of BK, mainly through an increase in stroke volume and a decrease in total peripheral resistance. In the same way, the renal vasoconstrictor effect of Ang II was abolished by the medium and high dose of BK. Hoe140 did not affect cardiac output or renal blood flow in this model. No influence of BK or Hoe140 on the increase in albuminuria induced by Ang II was detected. In conclusion, exogenous BK may oppose the effect of Ang II on vascular tone, but it cannot prevent hypertension and target-organ damage associated with this experimental model of hypertension, even at a very high dose.  (+info)

Cyclosporine nephrotoxicity in type 1 diabetic patients. A 7-year follow-up study. (7/2491)

OBJECTIVE: To evaluate kidney function 7 years after the end of treatment with cyclosporine A (CsA) (initial dosage of 9.3 tapered off to 7.0 mg.kg-1.day-1) in young patients (mean age 20 years) with newly diagnosed type 1 diabetes participating in a randomized, double-blind, placebo-controlled CsA trial. RESEARCH DESIGN AND METHODS: In this study, 21 patients received CsA for 12.5 +/- 4.0 months (mean +/- SD) and 19 patients received placebo for 14.4 +/- 3.8 months. The two groups were similar with regard to mean arterial blood pressure (BP), urinary albumin excretion rate (UAER), serum creatinine, and estimated glomerular filtration rate (GFR [Cockcroft and Gault]) at initiation of CsA treatment (baseline). HbA1c (mean +/- SEM) during 7 years of follow-up was also the same: 8.7 +/- 0.4 vs. 8.3 +/- 0.4% in the CsA and placebo groups, respectively. RESULTS: During the 7 years after cessation of study medication, two CsA group patients and one control patient were lost to follow-up. One placebo-treated patient developed IgA nephropathy (biopsy proven) and was excluded. Four CsA-treated patients developed persistently elevated UAER > 30 mg/24 h (n = 3 with microalbuminuria), whereas all the 17 placebo-treated patients had normal UAER (< 30 mg/24 h) after 7 years of follow-up. At the end of follow-up, the CsA group had a more pronounced rise in UAER: 2.5-fold (95% CI 1.4-4.5) higher than baseline value vs. 1.1-fold (0.7-1.7) in the placebo-treated group (P < 0.05). Estimated GFR (ml.min-1.1.73 m-2) declined from baseline to end of follow-up (1994) by 6.3 +/- 6.0 in the former CsA group, whereas it rose by 7.4 +/- 5.0 in the placebo group (P = 0.05). In 1994, 24-h blood pressure was nearly the same: 131/77 +/- 4/2 vs. 127/75 +/- 2/2 mmHg (NS) in the CsA and placebo groups, respectively. Five randomly selected CsA-treated patients had a kidney biopsy performed shortly after the CsA treatment was stopped. Interstitial fibrosis/tubular atrophy and/or arteriolopathy were present in two subjects who both subsequently developed persistent microalbuminuria. CONCLUSIONS: The results of our 7-year follow-up study suggested that short-lasting CsA treatment in young, newly diagnosed type 1 diabetic patients accelerated the rate of progression in UAER and tended to induce a loss in kidney function. Longer term follow-up is mandatory to clarify whether CsA-treated patients are at increased risk of developing clinical nephropathy.  (+info)

Microalbuminuria prevalence varies with age, sex, and puberty in children with type 1 diabetes followed from diagnosis in a longitudinal study. Oxford Regional Prospective Study Group. (8/2491)

OBJECTIVE: The predictive value of microalbuminuria (MA) in children with type 1 diabetes has not been defined. We describe the natural history of MA in a large cohort of children recruited at diagnosis of type 1 diabetes. RESEARCH DESIGN AND METHODS: Between 1985 and 1996, 514 children (279 male) who developed type 1 diabetes before the age of 16 years (91% of those eligible from a region where ascertainment of new cases is 95%) were recruited for a longitudinal study with central annual assessment of HbAlc and albumin excretion (three urine samples). Dropout rates have been < 1% per year, and 287 children have been followed for > 4.5 years. RESULTS: MA (defined as albumin-to-creatinine ratio > or = 3.5 and > or = 4.0 mg/mmol in boys and girls, respectively) developed in 63 (12.8%) and was persistent in 22 (4.8%) of the subjects. The cumulative probability (based on the Kaplan-Meier method) for developing MA was 40% after 11 years. HbAlc was worse in those who developed MA than in others (mean difference +/- SEM: 1.1% +/- 0.2, P < 0.001). In subjects who had been 5-11 years of age when their diabetes was diagnosed, the appearance of MA was delayed until puberty, whereas of those whose age was < 5 years at diagnosis of diabetes, 5 of 11 (45%) developed MA before puberty. The adjusted proportional probability (Cox model) of MA was greater for female subjects (200%), after pubertal onset (310%), and with greater HbAlc (36% increase for every 1% increase in HbAlc). Despite earlier differences based on age at diagnosis of diabetes (< 5, 5-11, and > 11 years), the overall cumulative risks in these groups were similar (38 vs. 29 vs. 39%, respectively) after 10 years' duration of diabetes. CONCLUSIONS: Prepubertal duration of diabetes and prepubertal hyperglycemia contribute to the risk of postpubertal MA. The differences in rates of development of MA relating to HbAlc, sex, and age at diagnosis relative to puberty may have long-term consequences for the risk of subsequent nephropathy and for cardiovascular risk.  (+info)

*Diabetes Control and Complications Trial

Intensive control therapy reduced albuminuria (300 mg/day) by 54%. Intensive control therapy reduced clinical neuropathy by 60 ...

*Proteinuria

Albuminuria Microalbuminuria List of terms associated with diabetes Protein toxicity Major urinary proteins URINALYSIS Ed ...

*Albuminuria

... and albuminuria category (A1, A2, A3). Causes of albuminuria can be discriminated between by the amount of protein excreted. ... Albuminuria is a pathological condition wherein the protein albumin is abnormally present in the urine. It is a type of ... The term albuminuria is now preferred in Nephrology since there is not a "small albumin" (microalbuminuria) or a "big albumin ... Also a urine dipstick test for proteinuria can give a rough estimate of albuminuria. This is because albumin is by far the ...

*Orthostatic albuminuria

Orthostatic proteinuria (synonyms: orthostatic albuminuria, postural proteinuria) is a benign condition. A change in renal ...

*Major urinary proteins

1933). "Albuminuria in the normal male rat". Journal of Physiology. 79 (2): 191-93. PMC 1394952 . PMID 16994453. Parfentjev IA ... Comper WD, Hilliard LM, Nikolic-Paterson DJ, Russo LM (2008). "Disease-dependent mechanisms of albuminuria". Am. J. Physiol. ...

*Glossary of diabetes

Albuminuria release of the protein albumin in urine. As this protein is strongly conserved, this is evidence of abnormal kidney ...

*List of Italian scientists

... discovered albuminuria (about a half century before Richard Bright); one of the first scientists to identify urea in human ...

*Microalbuminuria

Albuminuria Abid O, Sun Q, Sugimoto K, Mercan D, Vincent JL (2001). "Predictive value of microalbuminuria in medical ICU ... Lin, Julie; Fung, Teresa T.; Hu, Frank B.; Curhan, Gary C. (2011-02-01). "Association of dietary patterns with albuminuria and ... Lin, Julie; Hu, Frank B.; Curhan, Gary C. (2010-05-01). "Associations of diet with albuminuria and kidney function decline". ... An albumin level above the upper limit values is called "macroalbuminuria", or sometimes just albuminuria. Sometimes, the upper ...

*Kidney disease

Lin, Julie; Fung, Teresa T.; Hu, Frank B.; Curhan, Gary C. (2011-02-01). "Association of dietary patterns with albuminuria and ... "Associations of diet with albuminuria and kidney function decline". Clinical Journal of the American Society of Nephrology. 5 ( ...

*Acute proliferative glomerulonephritis

It can be a risk factor for future albuminuria. In adults, the signs and symptoms of infection may still be present at the time ...

*Hermann Senator

He was the author of influential works associated with diabetes and albuminuria, and is credited with disproving the once held ... Gansevoort, RT; Ritz, E. "Hermann Senator and albuminuria--forgotten pioneering work in the 19th century". Nephrol Dial ... Berlin, A. Hirschwald, 1882, (Albuminuria in healthy and diseased states); translated into several foreign languages. Die ... belief that albuminuria was always a sign of primary kidney disease. His treatise on diseases of the kidneys, "Die Erkrankungen ...

*Renal osteodystrophy

Lucas RC (1833). "Form of late rickets associated with albuminuria, rickets of adolescents". The Lancet. 1: 993-994. doi: ...

*Diabetic nephropathy

Albumin measurements are defined as follows: Normal albuminuria: urinary albumin excretion ... called albuminuria). As diabetic nephropathy progresses, a structure in the glomeruli known as the glomerular filtration ... on the measurement of abnormal levels of urinary albumin in a diabeticcoupled with exclusion of other causes of albuminuria. ...

*Hypertensive kidney disease

This leads to an elevated concentration of albumin in the urine (albuminuria). This albuminuria usually does not cause symptoms ...

*Heinrich von Bamberger

He provided early descriptions of hematogenous albuminuria, uremic pericarditis and progressive polyserositis. The eponymous " ... Volume 15 Bamberger's albuminuria @ Who Named It JAMA: The Journal of the American Medical Association, Volume 25 Bamberger's ...

*Petroleum ether

Other clinical findings include albuminuria, hematuria, hepatic enzyme derangement, and cardiac arrhythmias. Doses as low as 10 ...

*Hydrocarbon pneumonitis

Other clinical findings include albuminuria, hematuria, hepatic enzyme derangement, and cardiac arrhythmias. Doses as low as 10 ...

*Serum albumin

Occasionally albumin appears in the urine of normal persons following long standing (postural albuminuria). Albumin functions ...

*Epidemiology of metabolic syndrome

In men the significant predictors of CVD were diabetes, age, LDL, albuminuria, and hypertension. Interestingly, and unlike ... The significant independent predictors of CVD in Native American women were diabetes, age, obesity, LDL, albuminuria, ...

*Finerenone

"Effect of Finerenone on Albuminuria in Patients with Diabetic Nephropathy: A Randomized Clinical Trial". JAMA. 314 (9): 884-94 ...

*Atrasentan

"The endothelin antagonist atrasentan lowers residual albuminuria in patients with type 2 diabetic nephropathy". Journal of the ...

*Hyperhomocysteinemia

... albuminuria : The Hoorn Study". Arteriosclerosis, Thrombosis, and Vascular Biology. 21 (1): 74-81. doi:10.1161/01.ATV.21.1.74. ...

*ENU

These diabetic mice had a dominant Akita mutation in the insulin-2 gene (Ins2Akita). These mice developed albuminuria, a ...

*Perlecan

Decreased perlecan in the glomerular basement membrane has a central role in the development of diabetic albuminuria. Perlecan ... "Diminished loss of proteoglycans and lack of albuminuria in protein kinase C-alpha-deficient diabetic mice". Diabetes. 53 (8): ...

*Menarini

"Blood pressure control is similar in treated hypertensive patients with optimal or with high-normal albuminuria". American ...
Smoking has been pinpointed as a factor causing progression of chronic nephropathies. It is worth noting that smoking increases urinary albumin concentration, even at albumin concentrations below that of microalbuminuria (1). There is growing evidence that smoking not only increases the risk of albuminuria but also the risk of renal functional deterioration. The frequency of nephropathy is progressively higher with increasing cigarette consumption. The available literature documents that smoking increases the risk of developing microalbuminuria, accelerates the rate of progression from microalbumunuria to manifest proteinuria, and accelerates the progression of renal failure (1). Chase et al. (2) reported that in a group of 359 young patients with type 1 diabetes, the prevalence of borderline and frankly elevated urinary albumin excretion rates was 2.8-fold higher in smokers than in nonsmokers. Concerning the risk of microalbumunuria progressing to overt proteinuria, a 4-year prospective study ...
Analytic note on comparing the urine albumin-creatinine ratio of the random urine (first collection) and the follow-up first-morning void urine (second collection). Persistent albuminuria, as measured by the urine albumin-creatinine ratio (ACR) in two urines from an individual, is used to determine the prevalence of stages 1 and 2 of chronic kidney disease. In NHANES 2009-2010, two urine samples were collected from participants ages 6 years and older. A random urine was initially collected in the NHANES mobile examination center (MEC). Participants were then asked to collect a first-morning void urine in their home within 10 days of the MEC examination.. The random urine (first collection) has a higher mean ACR compared with the mean of the first-morning void urine (second collection) because of factors such as orthostatic (postural) proteinuria and exercise. For participants 20 years and older in NHANES 2009-2010 (n=5247), the weighted (using MEC examined sample weights) mean random ACR (first ...
Background: Microalbuminuria in diabetes is strongly predictive of nephropathy, end-stage renal disease, and premature cardiovascular morbidity and mortality. Effective preventive therapies are therefore a clinical priority.. Objective: To determine whether the angiotensin-receptor blocker candesartan compared with placebo affects microalbuminuria incidence or rate of change in albuminuria in type 1 and type 2 diabetes.. Design: 3 randomized trials of the DIRECT (Diabetic Retinopathy Candesartan Trials) Program.. Setting: 309 secondary care centers.. Patients: 3326 and 1905 patients with type 1 and type 2 diabetes, respectively. Most were normotensive, and all had normoalbuminuria (median urinary albumin excretion rate, 5.0 µg/min).. Intervention: Candesartan, 16 mg/d increasing to 32 mg/d, versus placebo. Assignment was done centrally using an interactive voice-response system. Patients, caregivers, and researchers were blinded to treatment assignment. During a median follow-up of 4.7 years, ...
Aims: To examine the relationships between baseline characteristics and urinary albumin excretion in the extensively phenotyped patients in the ALiskiren Observation of heart Failure Treatment ( ALOFT ) study. Methods and results: Urinary albumin creatinine ratio ( UACR ) was available in 190 of 302 ( 63% ) patients randomized in ALOFT. Of these, 107 ( 56% ) had normal albumin excretion, 63 ( 33% ) microalbuminuria, and 20 ( 11% ) macroalbuminuria. Compared with patients with normoalbuminuria, those with microalbuminuria had a greater prevalence of diabetes ( 48 vs. 26%, P = 0.005 ) and a lower estimated glomerular filtration rate ( eGFR ) ( 60.7 vs. 68.3 mL/min/1.73 m2, P = 0.01 ). Patients with macroalbuminuria had additional differences from those with a normal UACR, including younger age ( 63 vs. 69 years, P = 0.02 ), higher glycated haemoglobin ( HbA1c; 7.9 vs. 6.2%, P | 0.001 ), and different echocardiographic findings. Of the non-diabetic patients, 28% had microalbuminuria and 7% had
The present data demonstrate that DHEA may be a causal intermediate in the relationship between degree of urinary albumin excretion and CVD in male patients with type 2 diabetes.. Albuminuria, a marker of established CVD (5) and an independent predictor of carotid intima-media thickness as determined by carotid ultrasonography (19), is associated with several known and potential CVD risk factors, including hypertension, dyslipidemia, increased platelet aggregability, and hyperinsulinemia (20-22). As an indication of increased renal endothelial permeability, albuminuria may be a convenient marker of diffuse endothelial dysfunction. Thus, albuminuria could serve as a readily determined marker of CVD as well as of existing endothelial dysfunction, being likely to reflect both macrovascular and microvascular disease.. Previous investigations could not establish a direct causal link between elevated urinary albumin excretion and increased CVD risk. Mattock et al. (23) demonstrated that ...
OBJECTIVES: There has been no report investigating the impact of the arterial stiffness reduction induced by antihypertensive medications on the improvement of target organ damage in hypertension. The aim of this study was to assess the association o
AIMS Cardiovascular events are the most relevant events in patients with diabetes mellitus. We aimed to compare the predictive values of N-terminal pro-brain natriuretic peptide (NT-proBNP) and the state-of-the-art marker, albuminuria, for cardiac events in diabetic patients. METHODS In this prospective observational study we recruited 1071 patients with diabetes mellitus. NT-proBNP and albuminuria ⊟ defined as a urinary albumin/creatinine ratio |30 mg/g were measured at baseline. Patients were followed during a mean observation period of 33.1 months. A total of 103 patients reached the defined endpoint (unplanned hospitalization due to a cardiac event or death). RESULTS The mean duration of diabetes was 15 ± 12 years and the mean HbA(1c) was 7.5 ± 3.1%. At baseline, 23.7% of the patients presented with albuminuria and 36.6% had plasma NT-proBNP values |125 pg/ml. Multiple Cox regression analysis including age, gender, duration of diabetes HbA(1c), albuminuria, and lnNT-proBNP revealed that lnNT
The exact time window of albuminuria onset in individual patients with diabetes mellitus or hypertension is difficult to identify, and to obtain renal tissues from patients with repetitive biopsies would be, for ethical reasons, not feasible. Thus, to identify the early molecular glomerular changes preceding the onset of albuminuria at the tissue level appears impossible in humans. In contrast, a recent study in the MWF rat model demonstrated the importance and feasibility of the experimental approach to obtain new insights into the sequence of events leading to the development of spontaneous albuminuria.13. We demonstrated that reduction of the nephron number in MWF animals and the consecutive increase in single glomerular filtration rate demonstrated previously in this strain9,16 associates with early adaptation of the glomerulus, which includes the development of glomerular hypertrophy in young MWF animals at 4 weeks of age.13 Moreover, preceding the onset of significant albuminuria at 6 ...
... definition. Explain albuminuria. What is albuminuria? albuminuria meaning. albuminuria sense. albuminuria FAQ. albuminuria synonyms.
Aim:. The primary aim of our study is to evaluate the antiproteinuric effect of irbesartan 300, 600 and 900 mg once daily in type 2 diabetic patients with microalbuminuria. Secondary to evaluate the effect on 24-h ambulatory blood pressure, glomerular filtration rate (GFR), urinary TGF beta excretion, and markers of endothelial dysfunction, and finally to evaluate the association between treatment response and genotypes with possible implications for the risk of cardiovascular disease.. Patients 60 type 2 diabetic patients with persistent microalbuminuria (at least two out of three 24-h urinary collections with albumin excretion between 30 and 300 mg/24-h).. Duration of study 38 weeks (8 weeks wash-out and 30 weeks of double-blind randomized cross-over (treatment with irbesartan 300, 600 and 900 mg for 10 weeks at each dose level)).. Design The study consists of an eight week wash-out period followed by a double-blind randomized three 10 week treatment period cross-over trial (please see ...
Albuminuria development in hypertensive patients is an indicator of higher cardiovascular (CV) risk and renal damage. Chronic renin-angiotensin system (RAS) suppression facilitates blood pressure control but it does not prevent from albuminuria development. We pursued the identification of protein indicators in urine behind albuminuria development in hypertensive patients under RAS suppression. Urine was collected from 100 patients classified in three groups according to albuminuria development: (a) patients with persistent normoalbuminuria; (b) patients developing de novo albuminuria; (c) patients with maintained albuminuria. Quantitative analysis was performed in a first discovery cohort by isobaric labeling methodology. Alterations of proteins of interest were confirmed by target mass spectrometry analysis in an independent cohort. A total of 2416 proteins and 1223 functional categories (coordinated protein responses) were identified. Immune response, adhesion of immune and blood cells, and ...
For microalbuminuria screening in patients with diabetes, measuring urinary albumin concentration (UAC) in random urine samples offers sensitivity and specificity similar to those of the albumin-to-creatinine ratio (ACR), reports a study in JAMA Internal Medicine.A meta-analysis was performed with the use of data on 2078 patients from 14 studies evaluating UAC and ACR in random urine samples. All studies included 24-hour urine collections as the criterion standard for diagnosis of microalbuminuria.
Define digestive albuminuria. digestive albuminuria synonyms, digestive albuminuria pronunciation, digestive albuminuria translation, English dictionary definition of digestive albuminuria. n. The presence of albumin in the urine, sometimes indicating kidney disease. al·bu′mi·nu′ric adj. n pathol the presence of albumin in the urine.
Micro- or macroalbuminuria is associated with increased cardiovascular risk factors among patients with type 2 diabetes, but whether albuminuria within the normal range predicts long-term cardiovascular risk is unknown. We evaluated the relationships between albuminuria and cardiovascular events in 1208 hypertensive, normoalbuminuric patients with type 2 diabetes from the BErgamo NEphrologic Diabetes Complication Trial (BENEDICT), all of whom received angiotensin-converting enzyme inhibitor (ACEI) therapy at the end of the trial and were followed for a median of 9.2 years. The main outcome was time to the first of fatal or nonfatal myocardial infarction; stroke; coronary, carotid, or peripheral artery revascularization; or hospitalization for heart failure. Overall, 189 (15.6%) of the patients experienced a main outcome event (2.14 events/100 patient-years); 24 events were fatal. Albuminuria independently predicted events (hazard ratio [HR], 1.05; 95% confidence interval [CI], 1.02-1.08). ...
In the Bakker abstract [Albumin-to-creatinine ratio in a timed overnight urine sample was accurate for screening for microalbuminuria in diabetes mellitus (1)], under the subheading "Description of tests and diagnostic standard," "Patients with UAER (20 mg/min)" should have been "Patients with UAER (20 µg/min ...
Introduction: Albuminuria is an important indicator of cardiovascular risk. Whether albuminuria predicts cardiovascular events independently of the baseline coronary artery state in patients with the metabolic syndrome (MetS) and in subjects who do not have the MetS has not been investigated yet.. Hypothesis: We hypothesized that albuminuria predicts cardiovascular events independently of the baseline coronary artery state both in patients with the MetS and in subjects who do not have the MetS. Methods: We measured urinary albumin and creatinine concentrations in 872 consecutive patients undergoing coronary angiography for the evaluation of established or suspected stable CAD. Albuminuria was defined as a urinary albumin to creatinine ratio (ACR) of 30 μg/mg or greater. Prospectively, we recorded vascular events over 3.1±1.2 years.. Results: During follow up, 17.5% of our patients suffered cardiovascular events. In the total study population, albuminuria significantly predicted the incidence ...
Current therapies targeting albuminuria in diabetic nephropathy leave residual urinary albumin secretion, which meanwhile leave residual cardiovascular risk. Previous studies demonstrated that sulodexide could reduce albuminuria in type 2 diabetic patients. But no data concerning Chinese population is available. The investigators aim to provide evidence of effects of sulodexide on diabetic nephropathy in Chinese diabetic patients. Further the investigators also test the hypothesis that sequential administration of intravenous and oral replacement of the drug would gain an earlier and greater reduction of albuminuria, compared with oral use only ...
To the Editor:. It was with great interest that I read the article in Circulation by Wang et al,1 who reported on the results of a recent analysis of low-grade albuminuria (UA) performed within the Framingham Heart Study. The authors found that UA increased the future risk for development of hypertension among the normotensive segment of the Framingham cohort. They concluded that UA can be considered as a useful biomarker for better targeting prehypertensive individuals for nonpharmacological intervention. These results are at variance with those from the Hypertension and Ambulatory Recording VEnetia STudy (HARVEST) recently published by our group.2 In a cohort of 1033 young subjects screened for stage 1 hypertension and never treated for the disease, we found that UA was not helpful for identifying those subjects destined to develop sustained hypertension requiring antihypertensive therapy. The reason for the discrepancy between the Framingham and HARVEST findings could be the different mean ...
BACKGROUND: Moderate-to-severe kidney disease increases risk for sudden cardiac death (SCD). Limited studies have evaluated how mild degrees of kidney dysfunction impact SCD risk.OBJECTIVE: The purpose of this study was to evaluate the association of albuminuria, which is one of the earliest biomarkers of kidney injury, and SCD.METHODS: The Reasons for Geographic and Racial Differences in Stroke (REGARDS) study is a prospective, population-based cohort of U.S. adults. Associations between albuminuria, which is categorized using urinary albumin-to-creatinine ratio (ACR), estimated glomerular filtration rate (eGFR), and SCD were assessed independently and in combination.RESULTS: After median follow-up of 6.1 years, we identified 335 SCD events. Compared to participants with ACR ,15 mg/g, those with higher levels had an elevated adjusted risk of SCD (ACR 15-30 mg/g, hazard ratio [HR] 1.53, 95% confidence interval [CI] 1.11-2.11; ACR ,30 mg/g, HR 1.56, 95% CI 1.17-2.11). In contrast, compared to the ...
In patients with insulin-dependent diabetes mellitus (IDDM), microalbuminuria is a predictor of widespread severe microangiopathy and macroangiopathy. Patients with microalbuminuria show generalized dysfunction of the vascular endothelium, but it is unknown whether endothelial dysfunction precedes the development of microalbuminuria. We examined a cohort of 17 IDDM patients at baseline and on three occasions during a follow-up of (median) 64 months (range 51-89). All had normal (| 15 micrograms/min) urinary albumin excretion (UAE) at the first three examinations. At the fourth examination, 11 patients had normal UAE and 6 had microalbuminuria (median 25.7 micrograms/min [range 15.3-42.8]). Compared with patients with normal UAE, microalbuminuric patients had significantly higher plasma levels of von Willebrand factor (vWF), a marker of endothelial dysfunction, at the second (200% [168-274] vs. 131% [69-186]), third (208% [188-270] vs. 125% [82-190]), and fourth examinations (231% [202-269] vs. 132% [88
We studied 42 white subjects with normal glucose tolerance and microalbuminuria and 79 with normoalbuminuria. Because we were studying healthy subjects on two occasions over a period of 3 years and needed to maximize subject compliance, we estimated AER both at screening and at recall on two rather than three collections, as would be usual in diabetic patients. In consequence, we used for our main classification of microalbuminuria an AER of 20 to 200 μg/min on either or both collections. We found that only 29% of individuals identified as microalbuminuric at screening remained so at follow-up, while 15% of normoalbuminuric subjects changed category. Microalbuminuria is thus a highly unstable variable in nondiabetic subjects. Nevertheless, we have previously shown it to be powerfully related to cardiovascular risk in this population.6 These observations suggest that, allowing for biological variability, the relationship between microalbuminuria (or its genetic or environmental determinants) and ...
Studies have shown that microalbuminuria may develop within 5 years of onset of insulin-dependent diabetes mellitus. In NIDDM, microalbuminuria may be present at the diagnosis of diabetes because the diagnosis is often delayed for several years after the onset of asymptomatic hyperglycemia. The most important reason for screening for microalbuminuria in patients with NIDDM has been its predictive power for progressive increases in albumin excretion and decline in renal function. This important meta-analysis by Dineen and Gerstein also confirms microalbuminuria in patients with NIDDM as a significant risk factor for cardiovascular morbidity and mortality. Many mechanisms for this increased cardiovascular risk have been postulated. For example, it may be caused by a generalized state of vascular hyperpermeability leading to increased penetration of lipoproteins into the subendothelial space or may simply be another manifestation of an atherogenic insulin-resistant state (1, 2). Currently, the ...
Background: Epidemiological studies have shown that microalbuminuria is an important risk factor for arteriosclerosis, coronary heart disease and other vascular diseases in persons with type 2 diabetes. In the present study we examined the prevalence and risk factors for micro- and macroalbuminuria and examined glycemic control as well as treatment of modifiable cardiovascular risk factors in persons with known type 2 diabetes in Germany. Methods: The presented data were derived from the `KORA Augsburg Diabetes Family Study, conducted between October 2001 and September 2002. Participants were adults aged 29 years and older with previously diagnosed type 2 diabetes (n = 581). Microalbuminuria was defined as an albumin-creatinine ratio of 30 to 300 mg/g, and macroalbuminuria as an albumin-creatinine ratio of more than 300 mg/g. Results: Microalbuminuria was revealed in 27.2% and macroalbuminuria in 9.0% of the 581 included diabetic persons. Multivariable regression analysis identified HBA1c, ...
There are three major findings from this prospective investigation in individuals with type 2 diabetes. First, patients with (micro)albuminuria and high plasma concentrations of soluble vascular cell adhesion molecule 1 (a putative marker of endothelial dysfunction) and C-reactive protein (a marker of inflammation) had an increased risk of death. Importantly, these associations were not only independent of conventional cardiovascular risk factors, but also of each other, which suggests that the pathway linking (micro)albuminuria to mortality does not involve endothelial dysfunction or increased inflammatory activity to the extent reflected by these markers. Second, however, markers of endothelial dysfunction and of inflammatory activity were strongly associated with increases in urinary albumin excretion during the 10-year follow-up. These associations were independent of major risk factors for developing (micro)albuminuria, such as high blood pressure and poor glycemic control. These findings ...
Normally, the glomerular filtration barrier almost completely excludes circulating albumin from entering the urine. Genetic variation and both pre- and postnatal environmental factors may affect albuminuria in humans. Here we determine whether glomerular gene expression in mouse strains with naturally occurring variations in albuminuria would allow identification of proteins deregulated in relatively leaky glomeruli. Albuminuria increased in female B6 to male B6 to female FVB/N to male FVB/N mice, whereas the number of glomeruli/kidney was the exact opposite. Testosterone administration led to increased albuminuria in female B6 but not female FVB/N mice. A common set of 39 genes, many expressed in podocytes, were significantly differentially expressed in each of the four comparisons: male versus female B6 mice, male versus female FVB/N mice, male FVB/N versus male B6 mice, and female FVB/N versus female B6 mice. The transcripts encoded proteins involved in oxidation/reduction reactions, ion transport,
Background: The objective was to evaluate the association of albuminuria with cancer mortalities in adults ages 50 and older.. Methods: A total of 6,112 adults ages 50 years and above without a history of cancer at baseline in the Third National Health and Nutrition Examination Survey (NHANES III, 1988-1994) were included in the analysis. Albuminuria was measured with urinary albumin-to-creatinine ratio (UACR) in mg/mmol. Cancer mortality was obtained from the NHANES III-linked follow-up database (up to December 31, 2006). Cox-regression models were used to examine the associations of interest.. Results: Albuminuria was present in 705 men (17.5%) and 592 women (14.3%). During an average follow-up of 149 months, 613 subjects died of cancers including 184 lung cancers, 65 colorectal cancers, 55 prostate cancers, and 309 other cancers. There was an increased mortality risk associated with logarithmically transformed UACR for all-cancer [relative risk (RR), 1.20; 95% confidence interval (CI), ...
... is measured as part of the urine/albumin creatinine ratio in the investigation of microalbuminuria in Diabetes Mellitus and in the further investigation of chronic kidney disease stage 3a and above.. ...
Retrospective studies of patients with non-insulin-dependent diabetes mellitus (NIDDM) have suggested that microalbuminuria predicts early all-cause (mainly cardiovascular) mortality independently of arterial blood pressure. These findings have not been confirmed in prospective studies, and it is not known whether the predictive power of microalbuminuria is independent of other major cardiovascular risk factors. During 1985-1987, we examined a representative group of 141 nonproteinuric patients with NIDDM for the prevalence of coronary heart disease and several of its established and putative risk factors, including raised urinary albumin excretion (UAE) rate. Thirty-six patients had microalbuminuria (UAE 20-200 μg/min), and 105 had normal UAE (, 20 μg/min). At follow-up, an average of 3.4 yr later, 14 patients had died. There was a highly significant excess mortality (chiefly from cardiovascular disease) among those with microalbuminuria (28%) compared to those without microalbuminuria (4%, P ...
Results:. Current smokers had a higher median albumin excretion than nonsmokers and were more likely to have microalbuminuria and high normal albuminuria with elevated or decreased GFR. After adjustment for several potential confounding factors, persons who smoked 20 or fewer cigarettes/d and persons who smoked more than 20 cigarettes/d, respectively, showed a dose-dependent association between smoking and high normal albuminuria (relative risk, 1.33 [95% CI, 1.10 to 1.61] and 1.98 [CI, 1.49 to 2.64]), microalbuminuria (relative risk, 1.92 [CI, 1.54 to 2.39] and 2.15 [CI, 1.52 to 3.03]), elevated GFR (relative risk, 1.82 [CI, 1.31 to 2.53] and 1.84 [CI, 1.12 to 3.02]), and decreased GFR (relative risk, 1.53 [CI, 1.04 to 2.24] and 1.83 [CI, 1.05 to 3.20]), respectively. Quitting smoking was associated only with microalbuminuria. ...
Methods: We analyzed longitudinal data from 1,436 participants in the Diabetes Control and Complications Trial. We defined average intake of eicosapentaenoic- and docosahexaenoic acid from diet histories. Urinary albumin excretion rates (UAER) were measured over 24 hours; incident albuminuria was considered the first occurrence of an UAER >40 mg/24 hr sustained for >/=1 year in normo-albuminuric individuals ...
Albuminuria, either micro- or macro-, is considered as an independent cardiovascular and renal risk factor that must be determined in any patient with diabetes and with arterial hypertension. The presence of microalbuminuria has also been shown to be a risk factor of similar magnitude in the general population,1 although the possibility of its estimation in the whole population remains as an elusive objective. Recently, 2 relevant issues related to albuminuria have been published: first, prevention of development of microalbuminuria has been demonstrated as an attainable objective in type 2 diabetic patients2 and, second, diminution of the urinary excretion of albumin has been shown to be followed by a significant decrease in the development of cardiovascular events and death.3 All of these facts enhance the need to improve our knowledge on predictors of the development and evolution of microalbuminuria. Further progression to macroalbuminuria occurs in a significant number of cases, ...
The current evidence-based recommendation by the American Diabetes Association (ADA) and the American Association of Clinical Chemistry (AACC) have suggested that semi-quantitative screening tests should have a clinical sensitivity exceeding 95% if they are to be used for detecting albuminuria.. In comparing both semi-quantitative and and quantitative POC test to this standard, the semi-quantitative test falls short.. Since the technical performance of the quantitative POC test for albuminuria is equivalent to that of laboratory tests, and its diagnostic accuracy meet the above standard, this opens the possibility of larger in-office screening and diagnosis of albuminuria and kidney disease.. ...
I too have to calculate the albumin to creatinine ratio in HTN patients (why dont lab reports do this!? but I digress….). You mention that the units have to be in mg/L or mg/mL but the example above has units in mg/dL (which is the units I see most often). If they are both in mg/dL will you get the same result? Also, are you multiplying the ratio by a thousand to get the units for the creatinine in grams or are you converting the microalbumin to albumin? Thanks!. ...
This large, international, multicenter, CV disease prevention trial-which found ramipril, but not vitamin E, protective-has clearly shown that the presence of albuminuria indicates increased risk for myocardial infarction, stroke, CV death, CHF, and all-cause mortality. This increase was true in patients with or without diabetes and in those receiving ramipril or placebo. The increase in risk began even below the threshold level for microalbuminuria used to indicate incipient diabetic nephropathy in patients with DM. The authors point out that many CV risk factors are associated with microalbuminuria, including smoking, dyslipidemia, hypertension, hyperhomocystinemia, dietary protein, and markers of acute phase response. Although the authors adjusted for many of these factors in the analyses, further research is necessary to more clearly assess the independent CV risk signaled by albuminuria. More important, researchers need to clarify whether increasing albuminuria is a causal risk factor for ...
Diabetic nephropathy (DN) is the leading cause of kidney failure in the world. To understand important mechanisms underlying this condition, and to develop new therapies, good animal models are required. In mouse models of type-1 diabetes, the DBA/2J strain has been shown to be more susceptible to develop kidney disease than other common strains. We hypothesized this would also be the case in type-2 diabetes. We studied db/db and wt DBA/2J mice and compared these with the db/db BLKS/J mouse, which is currently the most widely used type-2 DN model. Mice were analyzed from age 6 to 12 weeks for systemic insulin resistance, albuminuria and glomerular histopathological and ultra-structural changes. Body weight and non-fasted blood glucose were increased by 8-weeks in both genders, while systemic insulin resistance commenced by 6-weeks in female and 8-weeks in male db/db DBA/2J mice. The urinary albumin-to-creatinine ratio (ACR) was closely linked to systemic insulin resistance in both sexes and was ...
Diabetes is a serious public health threat that leads to a variety of complications including diabetic nephropathy. Initiated by elevated blood glucose levels, glomerular and proximal tubule damage promotes progressive nephron deterioration leading to end stage renal failure. A common indicator of impending kidney failure is an increase in urinary albumin levels. Urinary proteins are efficiently reabsorbed via receptor-mediated endocytosis in the epithelial cells of the renal proximal tubules by endocytic proteins megalin and cubilin. CD13 has been previously identified as a negative regulator of receptor-mediated endocytosis of numerous cell types. Urinary albumin levels were significantly decreased in CD13KO animals compared to wild type animals in models of diabetic nephropathy and albumin overload. CD13 negatively regulates receptor-mediated endocytosis of albumin in proximal tubules. Currently, there are limited reliable biomarkers that accurately detect renal injury and its progression. Single
Background: Microalbuminuria (MA) is a known predictor of cardiovascular disease (CVD) in European origin populations, but such data are lacking in native Indo-Asian populations, where CVD risks are high. Major electrocardiographic (ECG) changes are predictive of cardiovascular mortality. We determined the association of MA with major ECG changes in the general population of Pakistan. Methods: A total of 3143 subjects aged ≥40 years from 12 randomly selected communities in Karachi participated. MA was defined as the urine albumin to creatinine (ACR) ratio of | 300 mg/g creatinine and ≥17 mg/g in men and ≥25 mg/g in women from a single-spot morning urine sample. Major changes on ECG were coded in duplicate using Minnesota classification. Results: The mean age of subjects was 51.5 (10.7) years. The median (25-75 percentile) ACR was 4.2 (2.9-7.9) mg/g in men and 6.0 (3.9-10.8) mg/g in women (P | 0.001). The overall prevalence (95% CI) of MA was 12.3% (11.1-13.5%), and 20.3% in those with major ECG
The MNSIE was completed in 399 subjects, including 329 youth with type 1 diabetes (mean age 15.7 ± 4.3 years, duration 6.2 ± 0.9 years) and 70 with type 2 diabetes (mean age 21.6 ± 4.1 years, duration 7.6 ± 1.8 years). Glycated hemoglobin (A1C) was similar in both groups (8.8 ± 1.8% for type 1 vs. 8.5 ± 2.9% for type 2). The prevalence of DPN was significantly higher in youth with type 2 compared with those with type 1 diabetes (25.7 vs. 8.2%; P < 0.0001). In unadjusted analyses, diabetes type, older age, longer duration of diabetes, increased waist circumference, elevated blood pressure, lower HDL cholesterol, and presence of microalbuminuria (urinary albumin-to-creatinine ratio >30 mg/g) were associated with DPN. The association between diabetes type and DPN remained significant after adjustment for age and sex (odds ratio 2.29 [95% CI 1.05-5.02], P = 0.03 ...
In this randomized clinical trial of subjects with CAD, daily supplementation with Lovaza for 1 year attenuated the worsening of albuminuria in diabetic subjects, the majority of whom had an ACR ,30 μg/mg. Moreover, significantly more (3‐fold) subjects on Lovaza had a decrease in ACR compared to control, and 3 on Lovaza had a change in category from ,30 to ,30 μg/mg whereas no controls did. These results suggest that there is benefit and perhaps even reversal of ACR with Lovaza at an early stage of disease in those with ACR ,30 μg/mg and those with microalbuminuria. Since ACE‐I or ARB therapy has been shown to reduce pathologic albuminuria and associated cardiovascular morbidity and mortality27, 28, 29 and is now considered standard of care for diabetic patients,30 we examined whether Lovaza added any benefit in diabetic subjects who were receiving ACE‐I or ARB treatment and had normal renal function. The current results show that Lovaza attenuated the increase in ACR in diabetic ...
Mutation of Pseudomonas aeruginosa specifying reduced affinity for penicillin G. Furthermore, when the HOG pathway was blocked, CFO2 also responded to oxidative and osmotic sildenafil citrate stress and the response of CFO1 was increased. There is also increasing evidence of an association between urinary albumin/creatinine ratio (ACR) and AKI.. Low-grade mucinous tumors of the appendix appear to have a simple histological structure. A total of 4277 Sudanese school-going sildenafil dosage adolescents (aged 11-17 years) from 23 schools who completed an anonymous self-administered questionnaire on the use of tobacco products. All patients were classified according to the three prognostic criteria sildenafil citrate generic viagra 100mg (NIH, AFIP and Nomogram MSKCC) and the three instruments were compared with the Kaplan-Meier method. Tetracycline is known to cause hepatic dysfunction in humans by inducing steatosis.. The results suggest that targeting both the Hsp70 family, as well as the Hsp90 ...
This was one of those snap quizzes, where you read an article, answer a couple questions, and get 0.25 CME credits. It had to do with biomarkers for cardiac risk. After plowing through a ton of obscure information about CRP, urinary albumin-to-creatinine ratio, and things like that, I get to the test questions: A 65-year-old…. ...
Only a minority of diabetic patients with DKD had quantitative albuminuria assessments. The relatively low proportion of DKD patients with ACEi or ARB prescriptions suggests a gap between healthcare practice and available scientific evidence during the study period. Increased albuminuria and older age were the most consistent predictors of subsequent eGFR decline (International Journal of Clinical Practice). ...
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URINE Albumin Urine with protein or albumin is related to Hypertension or Diabetic. Kidneys normally prevent large molecules such as albumin from being excreted in the urine, high levels of urinary albumin excretion, called albuminuria, also indicates kidney is some how not functioning properly. It also reflects dysfunction of endothelial cells throughout the body, which…
Olmesartan reduced the risk of microalbuminuria by 23% in normoalbuminuric patients with Type 2 diabetes and at least one additional cardiovascular
2007 (English)In: British Journal of Obstetrics and Gynecology, ISSN 1470-0328, E-ISSN 1471-0528, Vol. 114, no 1, 119-119 p.Article in journal, Letter (Refereed) Published ...
BARCELONA -- Even when macro albuminuria is not observed in a diabetic patient, it is not a guarantee that the patient is free of advanced chronic kidney disease, researchers reported here.
... which is also called Proteinuria is the condition of having excessive urine-protein levels indicating kidney problems or possible kidney failure.
Experimental and pathological albuminuria : a contribution to the study of the source from which the proteid excreted in normal and pathological conditions of the kidney is derived ...
Since the time of Bright, albuminuria has commonly been associated with disease of the kidneys. More recently the distinction has been made between non-nephriti
Efect of short term glycemic control on microalbuminuria and glomerular filtration rate in type 2 diabetic patients with poor glycemic control ...
This study is a secondary analysis of incident CKD and incident albuminuria performed in a subgroup of SPRINT (a randomized, controlled, open-label trial) participants without baseline CKD. Participants were ≥50 years of age, had a SBP of 130 to 180 mm Hg, and had a heightened risk for CVD. Recruitment took place between November 2010 and March 2013. Participants were randomly assigned to an intensive or standard SBP control group. In the intensive group, 3 326 and 3 295 participants were analyzed for CVD and CKD outcomes, respectively. In the standard group, 3 336 and 3 295 corresponding participants were analyzed. Researchers found that at 6 months, there was a difference in adjusted mean estimated glomerular filtration rate (eGFR) of -3.32 mL/min/1.73 m2 (95%CI, -3.90 to -2.74 mL/min/1.73 m2) between the intensive and standard SBP lowering groups. At 18 months, the difference was -4.50 mL/min/1.73 m2 (CI, -5.16 to -3.85 mL/min/1.73 m2), with subsequent rates remaining relatively stable. At ...
Isolated microalbuminuria indicates a poor medical prognosis.: Isolated microalbuminuria indicates a poor prognosis and warrants medical attention.
I am a 36 years old man having |b|microalbumin level|/b| at 99.8 mcg/ml in my urine sample; creatinine is 199.97 mg/dl, UA/C ratio is at 49.91 ug/mg. My HbA1c is 4.6% and my average blood glucose level is 67.18 mg/dl. What could be the cause for such a high level of microalbumin? What course of action should be taken?
... ,For the quantitative in vitro determination of Microalbumin in human urine.,medicine,medical supply,medical supplies,medical product
In type 2 diabetics with microalbuminuria, irbesartan reduces albumin excretion independent of its antihypertensive effect. That, according to the results of a randomized controlled trial reported in the November issue of Diabetes Care. Angiotensin-converting enzyme (ACE) inhibitors delay the progression from
Urinalysis, quantitation of Protein urine or Albumin urine is indicated for the diagnosis and monitoring of the nephrotic syndrome and progressive renal disease.. In Diabetes mellitus, quantitation of Albumin urine to detect slight increases (microalbuminuria) is indicated for early detection of diabetic nephropathy.. Quantitation may be performed on random, timed or 24 hour urine collections.. See also Proteinuria.. ...
Pioglitazone delays proximal tubule dysfunction and improves cerebral vessel endothelial dysfunction in normoalbuminuric people with type 2 diabetes mellitus.
In this report we explore the hypothesis that arterial stiffness indices, which predict cardiovascular disease, might also correlate with microalbuminuria (MA) in type 1 diabetes (T1D), and thus have potential for risk assessment. Three pulse wave an
In our long-term studies on Natural History of Microalbuminuria (MA) in type 1 diabetes we found that in the majority of patients MA regresses to normo-albuminu...
Online Doctor Chat - Microalbumin and urinary analysis test, Ask a Doctor about Urinalysis, Online doctor patient chat conversation by Dr. Jyoti Patil
Liquid, human urine based control for monitoring the precision of Microalbumin test procedures; designed using human Albumin for testing across a wide range of popular instruments
1. The proteids consisted of albumins and globulins, varying in quantity between the extremes of .9010 grm. and .2592 grm. in the 24 hours, but usually between .7 and .37 grm., the average being .5317 grm.. 2. The quantity of the proteids varies directly as the urea, inversely as the external temperature. The relation between the quantity of urine and the quantity of proteid is not constant. The quantity of the proteida is little affected by diuretics; it tends to be increased by certain drugs that act upon the circulation. It is lessened during sleep.. It is apt to suffer a sudden temporary increase, returning as suddenly to the usual average. For this phenomenon we have no explanation.. 3. From .5449 to .6616 grm. of coagulable proteids a day (.0079 to .0094 grm. per kilo of body-weight) may be excreted through the urine for an indefinite time by an otherwise healthy individual without damage to either kidneys or organism.. ...
strouding entanglingly retroiridian eponymous antimachinery tauryl sprowsy ungenerate proabsolutism playbox cystoadenoma turbodynamo seismologue hancockite hierurgical acquaint outbounds sampaloc Alfurese [email protected] ...
So I was being so good. I had no tests in the house but I was getting crazy symptoms. So DH and I are at the Dollar Tree, shopping for the bbq and I caved and bought a test. Dh was SOO mad at me. But I got it anyway. I put it under the counter and said it would be for tomorrow morning. About 10 seconds later I was ripping it open. So I tested this afternoon (11Dpiui and not firt morning urine ...
Increased urinary albumin excretion is an important marker of kidney injury and a strong risk factor for cardiovascular disease. Black individuals have higher levels of urinary albumin excretion than white individuals, which may contribute to racial disparities in cardiovascular outcomes," according to background information in the study. Previous research indicated that the association of urinary albumin-to-creatinine ratio (ACR) with incident stroke differed by race, such that higher urinary ACR was independently associated with a greater risk of incident stroke in black individuals but not in white individuals. Whether similar associations extend to coronary heart disease (CHD) is unclear. Orlando M. Gutierrez, M.D., M.M.Sc., of the University of Alabama at Birmingham, and colleagues conducted a study to determine whether the association of urinary albumin excretion with CHD events differs by race. The study included black and white U.S. adults, 45 years and older, who were enrolled within ...
Renin-angiotensin-aldosterone system inhibitors prevent the progression of kidney disease in patients with diabetic nephropathy, and we studied how that benefit varies by the type of diabetes and baseline urinary albumin. We pooled data from 49 randomized controlled trials in a meta-analysis using the ratio of endpoint urinary albumin levels in those treated compared to those untreated with renin-angiotensin-aldosterone system inhibitors in both fixed- and random-effects models. The urinary albumin excretion for treated microalbuminuric patients with Type 1 diabetes was on average 60% lower at the end of the trial compared with patients not treated with renin-angiotensin- aldosterone system inhibitors using the fixed-effects model and 67% lower using the random-effects model. There was no significant effect of treatment in patients with normal albumin excretion. For normoalbuminuric patients with Type 2 diabetes, urinary albumin excretion was on average 12% lower after treatment using the fixed-effects
Looking for online definition of postural albuminuria in the Medical Dictionary? postural albuminuria explanation free. What is postural albuminuria? Meaning of postural albuminuria medical term. What does postural albuminuria mean?
Chronic kidney disease (CKD) is defined as the presence of kidney damage or an estimated glomerular filtration rate (eGFR) less than 60 ml/min/1.73 mt2, persisting for 3 months or more, irrespective of the cause.[1] It is a state of progressive loss of kidney function ultimately resulting in the need for renal replacement therapy (dialysis or transplantation). Kidney damage refers to pathologic abnormalities either suggested by imaging studies or renal biopsy, abnormalities in urinary sediment, or increased urinary albumin excretion rates. The 2012 KDIGO CKD classification recommends details about the cause of the CKD and classifies into 6 categories based on glomerular filtration rate (G1 to G5 with G3 split into 3a and 3b). It also includes the staging based on three levels of albuminuria (A1, A2, and A3), with each stage of CKD being sub-categorized according to the urinary albumin-creatinine ratio in (mg/gm) or (mg/mmol) in an early morning
We can confirm that dual blockade of the renin-angiotensisn system, both at the level of ACE and at the level of the AII receptor, is associated with more effective reduction in blood pressure than observed with a single agent and that this observation extends to patients with diabetes. We cannot, however, determine from the present study if these further effects on urinary albumin excretion relate to more effective reduction in blood pressure or to more complete blockade of the renin-angiotensin system. Our results provide additional evidence for a role for agents which interrupt the renin-angiotensin system in conferring renoprotective effects in patients with incipient diabetic nephropathy.. Our results are consistent with experimental data that emphasise the central role of interruption of the renin-angiotensin system in mediating the renoprotective effects of ACE inhibitors.13 We cannot exclude that the similarity in effects between ACE inhibitors and AII receptor antagonists relates ...
We can confirm that dual blockade of the renin-angiotensisn system, both at the level of ACE and at the level of the AII receptor, is associated with more effective reduction in blood pressure than observed with a single agent and that this observation extends to patients with diabetes. We cannot, however, determine from the present study if these further effects on urinary albumin excretion relate to more effective reduction in blood pressure or to more complete blockade of the renin-angiotensin system. Our results provide additional evidence for a role for agents which interrupt the renin-angiotensin system in conferring renoprotective effects in patients with incipient diabetic nephropathy.. Our results are consistent with experimental data that emphasise the central role of interruption of the renin-angiotensin system in mediating the renoprotective effects of ACE inhibitors.13 We cannot exclude that the similarity in effects between ACE inhibitors and AII receptor antagonists relates ...
Methods-We retrospectively reviewed 85 consecutive patients with acute small subcortical infarcts in the lenticulostriate artery territory who were admitted to our stroke center within 24 hours of symptom onset and underwent serial diffusion-weighted imaging (DWI). Albuminuria was determined based on the urinary albumin-to-creatinine ratio obtained from a first morning spot urine after admission. Infarct volume was measured on axial sections of the initial and follow-up DWI. Early neurological deterioration (END) was defined as an increase of ≥2 points in the National Institutes of Health Stroke Scale score during the first 5 days after admission.. ...
Objective. To explore the relationship between adiponectin and albuminuria in a large group of overweight and obese nondiabetic individuals after controlling for potential confounders. Material and Methods. Detailed anthropometiy, computed tomography-measured visceral abdominal adipose tissue, 24-h albuminuria, adiponectin and a series of biochemical parameters were assessed. Four hundred forty patients, predominantly of Caucasian origin, were included (80.2% female). A multiple linear regression model was developed, with albuminuria as the dependent variable and potential predictors as independent variables. Results. The mean age was 40 +/- 13 years, the mean body mass index was 35.7 +/- 6.6 kg/m(2), and the median visceral abdominal adipose tissue was 142.4 (92.3-194.0) cm(2). 10.9% of subjects exhibited microalbuminuria. The median adiponectin level was 9.08 (6.23-12.94) mu g/ml, and the median fasting serum glucose level was 83 (77-89) mg/dl. The strongest significant univariate correlations ...
Looking for online definition of microalbuminuria screening in the Medical Dictionary? microalbuminuria screening explanation free. What is microalbuminuria screening? Meaning of microalbuminuria screening medical term. What does microalbuminuria screening mean?
We have demonstrated for the first time that not only the brachial artery but also retinal and intrarenal hemodynamic responses to an intravenous infusion of l-arginine are impaired in type 2 diabetic patients. Despite no significant difference in the vascular responses of the retinal and brachial arteries after the nitroglycerin administration between the patient and control groups, there were significant differences in the vascular responses of these arteries in both the normoalbuminuric and microalbuminuric patients compared with the control subjects after the l-arginine infusion, suggesting that the endothelium-dependent vascular responses in the retinal and brachial arteries are impaired but that the responsiveness of the smooth muscle to exogenous NO is not impaired in diabetic patients. On the other hand, the reduction in vascular resistance of the interlobar artery after the nitroglycerin administration was significantly lower in the microalbuminuric patients than in the control ...
Acyclovir is a drug that is used to treat shingles, genital herpes, and chickenpox? If youre like most parents, citalopram uk you probably have old medications and leftover prescriptions taking up space in your medicine cabinet! After separating layers, the organic layer was back extracted with 1% TFA/H 2O (500mL)! Con 1 dosis materna de valaciclovir de 500 mg 2 veces al día, citalopram and cannabinoids este nivel expondría al lactante amamantado a una dosis diaria oral de aciclovir de alrededor de 061 mg/kg/día! Prevent any disease without the supervision of a medical doctor? In another further embodiment, citalopram uk the phenyl R 7 group is substituted with an amino group. In this meta-analysis, we looked at studies that compared the eradication success rate of H! Trega das barracas aos ambulantes da Rua Grande? The results are reported as a urine albumin-to-creatinine ratio? 2074 clomid canada trenchantly (2011), al-Kidd argued that his arrest and detention as a material witness ...
How is urinary albumin to urinary creatinine ratio abbreviated? UA/UC stands for urinary albumin to urinary creatinine ratio. UA/UC is defined as urinary albumin to urinary creatinine ratio very rarely.
RESULTS: CTRP9 was detected in plasma from 14 out of a total of 28 patients. The values were not normally distributed. In comparing between groups in which CTRP9 was or was not detected, there were statistically significant differences in the high molecular weight adiponectin (HAN) and the urinary albumin/creatinine ratio (ACR). This indicates that both CTRP9 and HAN reflect the pathophysiology of renal involvement in T2DM. HAN correlated with Body Mass Index, ACR, and homeostasis model assessment of insulin resistance. However, CTRP9 did not correlate with HAN or any other parameters ...
Diabetes has become the main public health challenge for the 21st century. Pronounced changes in the human environment and in human behavior and lifestyle, have accompanied globalization, and these have resulted in escalating rates of diabetes. Microalbuminuria is considered as a clinically important indicator of deteriorating renal function in diabetic patients. Microalbuminuria is the strong predictor of diabetic nephropathy, which is the main cause of mortality and morbidity in patients with diabetes mellitus. It is also characterized by increased prevalence of arterial hypertension, proliferative retinopathy, and peripheral neuropathy. Detection of microalbuminuria is an indication for initiation of appropriate therapy for the purpose of preventing the advance of progressive diabetic nephropathy. Diabetic kidney disease or nephropathy is the most common cause of end stage renal disease (ESRD) or kidney failure. One of the early markers of not only diabetic nephropathy, but also vascular disease
BACKGROUND: Urine albumin excretion in the high normal range [urine albumin to creatinine ratio (UACR) 10-29 mg/g)] predicts hypertension in European-origin populations. However, the prognostic significance of UACR in the high normal range for incident hypertension is unclear in Indo-Asians. The objective of this study was to examine the relationship of normal to high normal levels of UACR and incident hypertension. METHODS: We conducted a nested cohort study within a cluster randomized controlled trial in Pakistan on 1272 normotensive non-diabetic adults aged ≥ 40 years with UACR/g. Incident hypertension was defined as new onset of systolic blood pressure (SBP) ≥ 140 mmHg or diastolic ≥ 90 mmHg or initiation of antihypertensive therapy. RESULTS: A total of 920 (72.3%) participants completed the 2-year final follow-up. During this time, 105 (11.4%) developed incident hypertension. In the multivariable model, the odds [95% confidence interval (CI)] for incident hypertension were 2.45(1.21-4.98)
... ? Diabetic Nephropathy is the most serious disease in kidney problems. It has so many common complications, so people need to pay attention to it in daily life.
The prevalence of CKD in men and women was 6.9% and 9.1%, respectively (p , 0.001). Besides gender itself, age distribution, frequency of obesity (BMI ≥ 25), and concurrent chronic diseases, including DM, hypertension, and dyslipidemia, were different according to gender. Thus, the risk of CKD is higher in women than men (OR, 1.354; p , 0.001), and the difference seems to be caused by the susceptibility to albuminuria (OR, 1.416; p , 0.001) rather than decreased GFR (OR, 1.057; p = 0.683). When GFR was estimated using the MDRD Study equation, the increased risks of GFR , 60 mL/min/1.73 m2 in women were observed in previous studies: OR, 3.16 (p , 0.001) using KNHANES III and IV-1 [12]; frequencies of 3.4%, 9.7%, 10.2%, and 4.6% in women, and 1.0%, 5.4%, 3.1%, and 2.6% were seen in men through KNHANES I-IV [13]. There seemed to be no difference in ACR according to gender in the previous study (10.1% and 10.3% in women and men, respectively) [11]. A similar observation was reported for ...
Abstract BACKGROUND: Microalbuminuria is an important risk factor for cardiovascular diseases. Microalbuminuria may be seen due to hypoxemia in patients with chronic obstructive pu..
TY - JOUR. T1 - Anti-glycation and anti-albuminuric effects of GLY-230 in human diabetes. AU - Kennedy, Laurence. AU - Pilar Solano, Maria. AU - Meneghini, Luigi. AU - Lo, Margaret. AU - Cohen, Margo P.. PY - 2010/2. Y1 - 2010/2. N2 - Background/Aims: Inhibiting nonenzymatic glycation with GLY-230 lowers glycated albumin without affecting hyperglycemia and ameliorates renal dysfunction in the db/db mouse, but the effects of this compound in man have not been assessed. We report results from the first clinical trial in patients with diabetes of this new glycation inhibitor. Methods: 21 diabetic men were randomly assigned to receive a total dose of 250, 500 or 750 mg of GLY-230 or placebo (1:1:1:1.2 ratio) daily for 14 days to evaluate safety and the effect of drug on plasma concentrations of glycated albumin and on urinary albumin. Results: GLY-230 dose-responsively decreased glycated albumin in all participants, in whom HbA1c did not change. Among participants exhibiting microalbuminuria at ...
Albuminuria versus GFR as markers of diabetic CKD progression KDIGO Controversies Conference: Diabetic Kidney Disease New Delhi, March 2012 Richard J MacIsaac PhD FRACP Director of Endocrinology & Diabetes,
article{3f16f9c6-3aba-41c7-9ff0-8c2ca2600ac6, author = {Torffvit, Ole and Tapia, Juan and Rippe, Bengt and Alm, Per and Willner, Julian and Tencer, Jan}, issn = {1873-460X}, language = {eng}, number = {6}, pages = {328--335}, publisher = {Elsevier}, series = {Journal of Diabetes and its Complications1992-01-01+01:00}, title = {Ambulatory blood pressure in type 2 diabetic patients with albuminuria; Relation to the renal function and structural lesions.}, url = {http://dx.doi.org/10.1016/j.jdiacomp.2004.03.004}, volume = {18}, year = {2004 ...
New Herbal Approaches for the Treatment of Diabetic Kidney Diseases and Its Therapeutic Implications: 10.4018/978-1-5225-5207-9.ch015: Diabetic Kidney Diseases (DKD) is a very serious complication of diabetes. There is recent steep rise in the prevalence of metabolic syndrome and DKD
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Diabetic nephropathy - MedHelps Diabetic nephropathy Center for Information, Symptoms, Resources, Treatments and Tools for Diabetic nephropathy. Find Diabetic nephropathy information, treatments for Diabetic nephropathy and Diabetic nephropathy symptoms.
In contrast to previous studies in which good glucose control prevented, but did not reverse, nephropathy in a model of Type 1 diabetes [2], in the present studies the ketogenic diet reversed nephropathy, as reflected by albumin/creatinine ratios, after it had developed in models of both Type 1 and Type 2 diabetes. The reversal of functional nephropathy was associated with robust normalization of expression of genes induced by oxidative and other forms of stress. In contrast to the complete reversal of nephropathy as reflected by albuminuria and gene expression, histological evidence of nephropathy was only partially reversed in the model for Type 2 diabetes (kidneys from the Akita mice were not available for histological analysis). This suggests, perhaps not surprisingly, that functional and molecular aspects of nephropathy reverse more quickly than morphological aspects of diabetic nephropathy ...
In contrast to previous studies in which good glucose control prevented, but did not reverse, nephropathy in a model of Type 1 diabetes [2], in the present studies the ketogenic diet reversed nephropathy, as reflected by albumin/creatinine ratios, after it had developed in models of both Type 1 and Type 2 diabetes. The reversal of functional nephropathy was associated with robust normalization of expression of genes induced by oxidative and other forms of stress. In contrast to the complete reversal of nephropathy as reflected by albuminuria and gene expression, histological evidence of nephropathy was only partially reversed in the model for Type 2 diabetes (kidneys from the Akita mice were not available for histological analysis). This suggests, perhaps not surprisingly, that functional and molecular aspects of nephropathy reverse more quickly than morphological aspects of diabetic nephropathy ...
Microalbumin/Creatinine Ratio urine test that may help to determine if kidneys are functioning normally. This test is an early indicator of kidney failure.
Archives issue of International Journal of Pharma and Bio Sciences which aims to cover the latest outstanding developments in the field of pharmaceutical and biological sciences
Our £3.4m funding has enabled the creation of a Diabetic Kidney Centre dedicated to the treatment and research of diabetic kidney disease.
Electronic bloom annal (EHRs) may advice doctors accommodate decidedly added good affliction to individuals with blazon 2 diabetes, according to a fresh abstraction appear in the Fresh England Journal of Medicine.. The advisers showed that back doctors use EHRs, they are decidedly added acceptable to administrate recommended tests to their diabetic patients. These screenings can ensure that individuals are appropriately authoritative their claret amoroso and alienated ailing affairs habits.. For the study, the aggregation advised annal from patients actuality advised at 21 medical offices about the greater Cleveland area. They were attractive to see if patients with blazon 2 diabetes accustomed testing for HbA1c levels, which actuate abiding claret amoroso control; urinary microalbumin, which can announce branch complications; eyes to analysis for signs of retinopathy and cholesterol. Additionally, the aggregation arrested to see if a pneumococcal anesthetic had been administered.. "EHR sites ...
Nephropathy (diabetic kidney disease) is the most common cause of kidney failure in the United States and the greatest threat to life in adults with Type 1
Mitochondrial dysfunction is a pathological mediator of diabetic kidney disease (DKD). Our objective was to test the mitochondrially targeted agent, MitoQ, alone and in combination with first line therapy for DKD. Intervention therapies (i) vehicle (D); (ii) MitoQ (DMitoQ;0.6 mg/kg/day); (iii) Ramipril (DRam;3 mg/kg/day) or (iv) combination (DCoAd) were administered to male diabetic db/db mice for 12 weeks (n = 11-13/group). Non-diabetic (C) db/m mice were followed concurrently. No therapy altered glycaemic control or body weight. By the study end, both monotherapies improved renal function, decreasing glomerular hyperfiltration and albuminuria. All therapies prevented tubulointerstitial collagen deposition, but glomerular mesangial expansion was unaffected. Renal cortical concentrations of ATP, ADP, AMP, cAMP, creatinine phosphate and ATP:AMP ratio were increased by diabetes and mostly decreased with therapy. A higher creatine phosphate:ATP ratio in diabetic kidney cortices, suggested a ...
According to WebMD, a normal albumin level is 3.5 to 5.0 grams per deciliter, or 35 to 50 grams per liter. This level is determined by a blood...
WHITE PHARMACEUTICALS - Exporter, Importer, Distributor, Supplier, Trading Company of Human Normal Albumin IP based in New Delhi, India
Diabetic nephropathy is a leading cause of end-stage renal disease in Japan. Microalbuminuria has been considered as the first clinical sign of diabetic nephropathy. However, recent studies demonstrated that normoalbuminuric renal insufficiency is not uncommon for diabetic patients, especially in type 2 diabetes. Although the pathogenesis of normoalbuminuric renal insufficiency in diabetic nephropathy remains to be fully elucidated, distinct clinical and pathological features of diabetic patients with this finding have been reported as compared to those in diabetic patients with a typical clinical course. In type 1 diabetes, more advanced glomerular lesions were found in patients with normoalbuminuric renal insufficiency than in patients with normoalbuminuric preserved renal function. In contrast, disproportionately advanced tubulointerstitial and vascular lesions, despite minor diabetic glomerular lesions, which denote the presence of diabetic kidney lesions as well as nephrosclerosis, were ...
eng] BACKGROUND: The TEMPO 3:4 Trial results suggested that tolvaptan had no effect compared with placebo on albuminuria in autosomal-dominant polycystic kidney disease (ADPKD) patients. However, the use of categorical albuminuria events may have resulted in a loss of sensitivity to detect changes. The aim of this study is to investigate the effects of tolvaptan on albuminuria as a continuous variable. METHODS: Post hoc analysis of a 3-year prospective, blinded randomized controlled trial, including 1375 ADPKD patients. Albuminuria was measured in a spot morning urine sample prior to tolvaptan dosing and expressed as albumin-to-creatinine ratio (ACR). RESULTS: Baseline median (interquartile range) ACR was 3.2 (1.7-7.1) mg/mmol. Of note, 47.9% of ADPKD patients had normal, 48.7% moderately increased and 3.4% severely increased ACR. Subjects with higher baseline ACR had higher blood pressure and total kidney volume (TKV) and lower estimated glomerular filtration rate (eGFR). During follow-up, ...
Serum IgA class reticulin autoantibody test was performed prospectively once a year on 238 children and adolescents with insulin dependent diabetes mellitus (IDDM). At the initial testing, within one year after onset of IDDM, five were positive and 233 were negative. During follow up a further 11 of the initially antibody negative children became positive (6.7%). Jejunal biopsy was performed at the appearance of the autoantibodies and silent coeliac disease was shown in nine (3.8%). One of these children showed on initial biopsy after the onset of IDDM to have normal jejunal mucosal architecture deteriorating later to a flat lesion. Jejunal immunohistochemical studies of another of the patients positive for reticulin autoantibodies but normal on routine biopsy showed an increased density of intraepithelially located gamma/delta T cells and aberrant HLA-DR expression in the crypts pointing to ongoing mucosal inflammation and potential coeliac disease. This study shows that in IDDM patients, ...
1. Microalbuminuria is a risk factor for cardiovascular disease in patients with insulin-dependent diabetes mellitus, and may be a marker of microvascular dysfunction including endothelial damage. The purpose of this study was to determine whether vasoconstrictor responses to NG-monomethyl-L-arginine, an inhibitor of endothelium-derived relaxing factor/nitric oxide biosynthesis, differ between healthy subjects and insulin-dependent patients with or without microalbuminuria.. 2. Twenty-eight insulin-dependent diabetic patients (14 with normal albumin excretion, 14 with microalbuminuria) were studied under euglycaemic conditions, together with 14 healthy control subjects. Forearm vascular responses to brachial artery infusions of NG-monomethyl-L-arginine, sodium nitroprusside (an endothelium-independent nitrovasodilator) and carbachol (an endothelium-dependent vasodilator) were determined by strain gauge plethysmography.. 3. Basal blood flow and vasodilator responses were similar in each group. ...
BACKGROUND: Few studies have directly compared the renoprotective effects of angiotensin II-receptor blockers and angiotensin-converting-enzyme (ACE) inhibitors in persons with type 2 diabetes. METHODS: In this prospective, multicenter, double-blind, five-year study, we randomly assigned 250 subjects with type 2 diabetes and early nephropathy to receive either the angiotensin II-receptor blocker telmisartan (80 mg daily, in 120 subjects) or the ACE inhibitor enalapril (20 mg daily, in 130 subjects). The primary end point was the change in the glomerular filtration rate (determined by measuring the plasma clearance of iohexol) between the baseline value and the last available value during the five-year treatment period. Secondary end points included the annual changes in the glomerular filtration rate, serum creatinine level, urinary albumin excretion, and blood pressure, the rates of end-stage renal disease and cardiovascular events, and the rate of death from all causes. RESULTS: After five ...
Five insulin dependent diabetic patients are reported on who had a few small retinal cotton-wool spots or soft exudates either totally isolated or associated with fewer than 10 microaneurysms. These observations suggest that cotton-wool spots may be an early finding in diabetic retinopathy. Significant biological abnormalities in these patients were high levels of glycosylated haemoglobin and mild increases in thrombin generation, indicating slight activation of the coagulation system. The possible significance of these clinical and biological findings is discussed. ...
Bappal et al. (1999) estimated the prevalence and incidence rates of permanent neonatal insulin dependant diabetes mellitus (PNIDDM) and described its profile in Oman by studying all children (five children) diagnosed with this condition between 1991 and 1995. They were also investigated by viral serology for TORCH and Coxackie virus, presence of islet cells antibodies by indirect immunofluorescence technique on human pancreatic sections, plasma C-peptide concentration by radioimmunoassay, and glycated hemoglobin. HLA typing of all the children was also undertaken. The treatment plan was the same in all the children with a combination of intermediate and short acting human insulin once or twice a day according to the patients needs. The prevalence and incidence rates (which included the prevalence of insulin dependant diabetes mellitus among the children of under five years) were estimated by using the final results of the general census of population which was published yearly by the Ministry ...
Is the Chronic Kidney Disease Epidemiology Collaboration creatinineâ cystatin C equation useful for glomerular filtration rate estimation in the elderly? Xun Liu,1,2,* Huijuan Ma,1,* Hui Huang,3 Cheng Wang,1 Hua Tang,1 Ming Li,1 Yanni Wang,1 Tanqi Lou1 1Division of Nephrology, Department of Internal Medicine, The Third Affiliated Hospital of Sun Yat-sen University, 2College of Biology Engineering, South China University of Technology, 3Department of Cardiology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, Peoples Republic of China*These authors contributed equally to the paperBackground: We aimed to evaluate the performance of the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) creatinineâ cystatin C equation in a cohort of elderly Chinese participants.Materials and methods: Glomerular filtration rate (GFR) was measured in 431 elderly Chinese participants by the technetium-99m diethylene-triamine-penta-acetic acid (99mTc-DTPA) renal dynamic imaging method, and was

Functional albuminuria definition | Drugs.comFunctional albuminuria definition | Drugs.com

Definition of functional albuminuria. Provided by Stedmans medical dictionary and Drugs.com. Includes medical terms and ... functional albuminuria. Definition: a collective term denoting types of benign albuminuria that are associated with physical ...
more infohttps://www.drugs.com/dict/functional-albuminuria.html

Postrenal albuminuria definition | Drugs.comPostrenal albuminuria definition | Drugs.com

Definition of postrenal albuminuria. Provided by Stedmans medical dictionary and Drugs.com. Includes medical terms and ...
more infohttps://www.drugs.com/dict/postrenal-albuminuria.html

The Significance of Albuminuria | The BMJThe Significance of Albuminuria | The BMJ

The Significance of Albuminuria. Br Med J 1873; 1 doi: https://doi.org/10.1136/bmj.1.631.132 (Published 01 February 1873) Cite ...
more infohttp://www.bmj.com/content/1/631/132.1

Albuminuria: Albumin in the Urine | NIDDKAlbuminuria: Albumin in the Urine | NIDDK

Reviews the signs of albuminuria and provides information about testing procedures and treatment options. ... Defines albuminuria and discusses who is at risk. ... Albuminuria: Albumin in the Urine Albuminuria: Albumin in the ... What is albuminuria?. Albuminuria is a sign of kidney disease and means that you have too much albumin in your urine. Albumin ... How is albuminuria detected?. A health care provider often tests for albuminuria using a urine dipstick test followed by a ...
more infohttps://www.niddk.nih.gov/health-information/kidney-disease/chronic-kidney-disease-ckd/tests-diagnosis/albuminuria-albumin-urine

Recurrence of Albuminuria during Pregnancy | The BMJRecurrence of Albuminuria during Pregnancy | The BMJ

Recurrence of Albuminuria during Pregnancy. Br Med J 1882; 2 doi: https://doi.org/10.1136/bmj.2.1146.1201 (Published 16 ...
more infohttp://www.bmj.com/content/2/1146/1201

Albuminuria | National Kidney FoundationAlbuminuria | National Kidney Foundation

What is albuminuria? Albumin is a type of protein that is normally found in the blood. Your body needs protein. It is an ... If I have albuminuria, does it mean I have kidney disease?. It may be an early sign of kidney disease, but your doctor will ... What is albuminuria?. Albumin is a type of protein that is normally found in the blood. Your body needs protein. It is an ... If I have albuminuria, will I need treatment?. If kidney disease is confirmed, your healthcare provider will create a treatment ...
more infohttps://www.kidney.org/atoz/content/albuminuria

Treatment of hypertension induced albuminuria | Science CodexTreatment of hypertension induced albuminuria | Science Codex

Treatment of hypertension induced albuminuria. Albuminuria is a renal disease that is found to be independently associated with ... Changes in albuminuria were considered to moderate prognostic value in routine evaluations. ACEIs and ARBs were prescribed in ... Hence, it was also advised that patients should use different antihypertensive drugs if their goal is to reduce albuminuria ... A multifactorial and early antialbuminuric treatment is suggested for patients even when albuminuria values are below the cut- ...
more infohttps://sciencecodex.com/treatment-hypertension-induced-albuminuria-624121

albuminuria | American Society of Nephrologyalbuminuria | American Society of Nephrology

A Combination of Change in Albuminuria and GFR as a Surrogate End Point for Progression of CKD Josef Coresh and Andrew S. Levey ... Combination of Changes in Estimated GFR and Albuminuria and the Risk of Major Clinical Outcomes Toshiaki Ohkuma, Min Jun, John ...
more infohttps://cjasn.asnjournals.org/keyword/albuminuria

Evaluation of Albuminuria HIV-Infected Patients - Tabular View - ClinicalTrials.govEvaluation of Albuminuria HIV-Infected Patients - Tabular View - ClinicalTrials.gov

Evaluation of Albuminuria HIV-Infected Patients. Official Title Prospective Evaluation of Albuminuria in HIV Positive Patients ... Evaluation of Albuminuria HIV-Infected Patients. The safety and scientific validity of this study is the responsibility of the ... Participants who are found to have albuminuria or proteinuria are asked to undergo a kidney biopsy for research purposes. The ... The earliest indicator of the possible presence of kidney disease is albuminuria (increased amounts of the protein albumin in ...
more infohttps://clinicaltrials.gov/ct2/show/record/NCT00524992?term=%22Metabolic+Syndrome%22&lup_s=06%2F21%2F2013&lup_d=14&show_rss=Y&sel_rss=mod14

Regulatory albuminuria | definition of regulatory albuminuria by Medical dictionaryRegulatory albuminuria | definition of regulatory albuminuria by Medical dictionary

What is regulatory albuminuria? Meaning of regulatory albuminuria medical term. What does regulatory albuminuria mean? ... Looking for online definition of regulatory albuminuria in the Medical Dictionary? regulatory albuminuria explanation free. ... regulatory albuminuria. reg·u·la·to·ry al·bu·min·ur·i·a. transitory albuminuria occurring after unusual physical exertion. ... Regulatory albuminuria , definition of regulatory albuminuria by Medical dictionary https://medical-dictionary. ...
more infohttps://medical-dictionary.thefreedictionary.com/regulatory+albuminuria

Evaluation of Albuminuria HIV-Infected Patients - Full Text View - ClinicalTrials.govEvaluation of Albuminuria HIV-Infected Patients - Full Text View - ClinicalTrials.gov

Albuminuria. Glomerulosclerosis, Focal Segmental. Urination Disorders. Urologic Diseases. Urological Manifestations. Signs and ... Participants who are found to have albuminuria or proteinuria are asked to undergo a kidney biopsy for research purposes. The ... The earliest indicator of the possible presence of kidney disease is albuminuria (increased amounts of the protein albumin in ... This study will examine the following: 1) how common albuminuria and proteinuria are among HIV-positive patients, 2) what ...
more infohttps://clinicaltrials.gov/show/NCT00524992?order=11

Association of Albuminuria and Cancer Mortality | Cancer Epidemiology, Biomarkers & PreventionAssociation of Albuminuria and Cancer Mortality | Cancer Epidemiology, Biomarkers & Prevention

Understanding the biological link between albuminuria and cancer will be critical for determining whether albuminuria ... Association of Albuminuria and Cancer Mortality. Yu-Sheng Lin, Fu-Chun Chiu, Jou-Wei Lin, Juey-Jen Hwang and James L. Caffrey ... Association of Albuminuria and Cancer Mortality Message Subject (Your Name) has forwarded a page to you from Cancer ... Results: Albuminuria was present in 705 men (17.5%) and 592 women (14.3%). During an average follow-up of 149 months, 613 ...
more infohttp://cebp.aacrjournals.org/content/early/2010/10/22/1055-9965.EPI-10-0617

Association of Albuminuria and Cancer Mortality | Cancer Epidemiology, Biomarkers & PreventionAssociation of Albuminuria and Cancer Mortality | Cancer Epidemiology, Biomarkers & Prevention

Understanding the biological link between albuminuria and cancer will be critical for determining whether albuminuria ... Association of Albuminuria and Cancer Mortality. Yu-Sheng Lin, Fu-Chun Chiu, Jou-Wei Lin, Juey-Jen Hwang and James L. Caffrey ... Association of Albuminuria and Cancer Mortality Message Subject (Your Name) has forwarded a page to you from Cancer ... Results: Albuminuria was present in 705 men (17.5%) and 592 women (14.3%). During an average follow-up of 149 months, 613 ...
more infohttp://cebp.aacrjournals.org/content/19/11/2950

Bamberger albuminuria | definition of Bamberger albuminuria by Medical dictionaryBamberger albuminuria | definition of Bamberger albuminuria by Medical dictionary

What is Bamberger albuminuria? Meaning of Bamberger albuminuria medical term. What does Bamberger albuminuria mean? ... Looking for online definition of Bamberger albuminuria in the Medical Dictionary? Bamberger albuminuria explanation free. ... Bamberger albuminuria. Bam·ber·ger al·bu·min·ur·i·a. (bambĕr-gĕr), obsolete term for hematogenous albuminuria that is ... Bamberger albuminuria - obsolete term for hematogenous albuminuria that is sometimes observed during the later phases of ...
more infohttp://medical-dictionary.thefreedictionary.com/Bamberger+albuminuria

albuminuriaalbuminuria

Explain albuminuria. What is albuminuria? albuminuria meaning. albuminuria sense. albuminuria FAQ. albuminuria synonyms. ... albuminuria. English Dictionary -> Letter A -> albuminuria. Search Dictionary: albuminuria Definition. *(n) the presence of ...
more infohttp://www.wordthrill.com/define/albuminuria/

Albuminuria Change and Risk of End-Stage Kidney DiseaseAlbuminuria Change and Risk of End-Stage Kidney Disease

Albuminuria change as a surrogate endpoint for progression of chronic kidney disease strongly supported by biological ... Change in albuminuria as a surrogate endpoint for progression of chronic kidney disease strongly supported by biological ... A study was done to assess the consistency of the association between change in albuminuria and risk of end-stage kidney ... Cohort data were eligible if participants were age 18 years or older, they had a repeated measure of albuminuria during an ...
more infohttp://www.diabetesincontrol.com/albuminuria-change-and-risk-of-end-stage-kidney-disease/

Albuminuria | Profiles RNSAlbuminuria | Profiles RNS

"Albuminuria" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... Kidney function, albuminuria and age-related macular degeneration in NHANES III. Nephrol Dial Transplant. 2011 Oct; 26(10):3159 ... This graph shows the total number of publications written about "Albuminuria" by people in this website by year, and whether " ... Relation of kidney function and albuminuria with atrial fibrillation (from the Heart and Soul Study). Am J Cardiol. 2009 Dec 1 ...
more infohttps://profiles.umassmed.edu/display/124201

PRELIMINARY OBSERVATIONS ON A CASE OF PHYSIOLOGICAL ALBUMINURIA | JEMPRELIMINARY OBSERVATIONS ON A CASE OF PHYSIOLOGICAL ALBUMINURIA | JEM

PRELIMINARY OBSERVATIONS ON A CASE OF PHYSIOLOGICAL ALBUMINURIA. Torald Sollmann, E. C. McComb ...
more infohttp://jem.rupress.org/content/3/1/137

Evolution, Risk Factors, and Prognostic Implications of Albuminuria in NIDDM | Diabetes CareEvolution, Risk Factors, and Prognostic Implications of Albuminuria in NIDDM | Diabetes Care

Evolution, Risk Factors, and Prognostic Implications of Albuminuria in NIDDM. Leo K Niskanen, Ilkka Penttilã, Markku Parviainen ... Evolution, Risk Factors, and Prognostic Implications of Albuminuria in NIDDM. Leo K Niskanen, Ilkka Penttilã, Markku Parviainen ... control subjects for any albuminuria; 5 years: 6.0 and 0.8%, P , 0.01; 10 years: 11.9 and 0.8%, P , 0.001). The most important ... Evolution, Risk Factors, and Prognostic Implications of Albuminuria in NIDDM Message Subject (Your Name) has forwarded a page ...
more infohttp://care.diabetesjournals.org/content/19/5/486

Podocyte Number in Normotensive Type 1 Diabetic Patients With Albuminuria | DiabetesPodocyte Number in Normotensive Type 1 Diabetic Patients With Albuminuria | Diabetes

Podocyte Number in Normotensive Type 1 Diabetic Patients With Albuminuria. Kathryn E. White, Rudolf W. Bilous, Sally M. ... Podocyte Number in Normotensive Type 1 Diabetic Patients With Albuminuria. Kathryn E. White, Rudolf W. Bilous, Sally M. ... Podocyte Number in Normotensive Type 1 Diabetic Patients With Albuminuria Message Subject (Your Name) has forwarded a page to ... Our cross-sectional data show that this group of type 1 diabetic patients with albuminuria but normal BP have increased numbers ...
more infohttp://diabetes.diabetesjournals.org/content/51/10/3083

Albuminuria Associated With Cognitive Decline, DementiaAlbuminuria Associated With Cognitive Decline, Dementia

Doctors from the University of Athens examined the correlation between albuminuria and cognitive impairment, dementia, and ... Albuminuria in Association with Cognitive Function and Dementia: A Systematic Review and Meta-Analysis. J Am Geriatr Soc. 2017 ... HealthDay News - Albuminuria is associated with cognitive impairment, dementia, and cognitive decline, according to a review ... The researchers found that albuminuria correlated with cognitive impairment, dementia, clinical Alzheimers disease, and ...
more infohttps://www.psychiatryadvisor.com/news/cognitive-impairment-dementia-and-cognitive-decline-are-linked-to-albuminuria/article/637788/

Differential dyslipidemia associated with albuminuria in type 2 diabetic patients in Taiwan.  - PubMed - NCBIDifferential dyslipidemia associated with albuminuria in type 2 diabetic patients in Taiwan. - PubMed - NCBI

Differential dyslipidemia associated with albuminuria in type 2 diabetic patients in Taiwan.. Tseng CH1. ... This study evaluated the lipid abnormalities associated with different stages of albuminuria in type 2 diabetic patients. ... Ln(TG) increased progressively with increasing albuminuria. In multivariate logistic regression analyses, only ApoB showed ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/19324028?dopt=Abstract

Albuminuria and Nephritis in Dairy Cows - Herbert John Metzger, Fordyce Ely, F. E. Hull - Google BooksAlbuminuria and Nephritis in Dairy Cows - Herbert John Metzger, Fordyce Ely, F. E. Hull - Google Books

acetic acid albuminuria and nephritis amount of albumin animals Apparently normal bladder Born breeder breeds calculi calves ... Albuminuria and Nephritis in Dairy Cows. Issue 373 of Bulletin (Kentucky Agricultural Experiment Station). Volume 373 of ... material postmortem notes regarding pus cells Record Date Albumin record is given samples of urine Sept showed albuminuria Sold ... gb-gplus-shareAlbuminuria and Nephritis in Dairy Cows. ... Albuminuria and Nephritis in Dairy Cows. Herbert John Metzger, ...
more infohttps://books.google.com/books/about/Albuminuria_and_nephritis_in_dairy_cows.html?id=N2EnAQAAMAAJ&hl=en

Albuminuria and Mortality in Hypertension | Annals of Internal Medicine | American College of PhysiciansAlbuminuria and Mortality in Hypertension | Annals of Internal Medicine | American College of Physicians

Albuminuria and Mortality in Hypertension Kristian Wachtell, MD, PhD; Michael Hecht Olsen, MD, PhD; Hans Ibsen, MD ... Wachtell K, Olsen MH, Ibsen H. Albuminuria and Mortality in Hypertension. Ann Intern Med. ;141:245. doi: 10.7326/0003-4819-141- ... Albuminuria and Cardiovascular Risk in Hypertensive Patients with Left Ventricular Hypertrophy: The LIFE Study ... In our study sample, the relative impact of blood pressure on the relation between albuminuria and cardiovascular outcome was ...
more infohttp://annals.org/aim/article-abstract/717713/albuminuria-mortality-hypertension
  • HealthDay News - Albuminuria is associated with cognitive impairment, dementia, and cognitive decline, according to a review published online in the Journal of the American Geriatrics Society . (psychiatryadvisor.com)
  • Albuminuria is a renal disease that is found to be independently associated with cardiovascular and renal problems without any links to diabetes. (sciencecodex.com)
  • Withdrawal of red meat from the usual diet reduces albuminuria and improves serum fatty acid profile in type 2 diabetes patients with macroalbuminuria. (wikipedia.org)
  • Our aim was to estimate the number of mesangial and endothelial cells and podocytes in a group of normotensive type 1 diabetic patients with albuminuria who were part of the European Study for the Prevention of Renal Disease in Type 1 Diabetes (ESPRIT) ( 11 , 12 ). (diabetesjournals.org)
  • It is concluded that albuminuria is associated with cancer incidence in individuals without a history of diabetes, macroalbuminuria, or previous cancer and that it might confer risks of varying magnitude for different types of cancer. (asnjournals.org)
  • Conclusions: It is becoming increasingly apparent that a considerable proportion of subjects with type 2 diabetes can develop renal impairment in the absence of albuminuria. (scirp.org)
  • Kramer, H.J., Nguyen, Q.D., Curhan, G. and Hsu, C.Y. (2003) Renal insufficiency in the absence of albuminuria and retinopathy among adults with type 2 diabetes mellitus. (scirp.org)
  • Gema Ruiz-Hurtado, PhD, from the Hospital Universitario 12 de Octubre in Madrid, and colleagues examined the quantitative differences in nighttime SBP across albuminuria levels in patients with and without diabetes and chronic kidney disease. (empr.com)
  • Albuminuria in hypertensive patients is accompanied by quantitatively striking higher nighttime SBP, particularly in those with diabetes with very high albuminuria and low eGFR," the authors write. (empr.com)
  • The ESPRIT study ( 11 ) was a multicenter, prospective, placebo-controlled, double-blind, randomized pilot study of the effects of an ACE inhibitor, enalapril, or a calcium channel blocker, nifedipine retard, on renal structure and function over a 3-year period in a group of normotensive type 1 diabetic patients with albuminuria. (diabetesjournals.org)
  • Albuminuria has also been observed in individuals with different kinds of cancers, such as lung, breast, renal cell, colon/rectal, and non-Hodgkin's lymphoma. (asnjournals.org)
  • Differential dyslipidemia associated with albuminuria in type 2 diabetic patients in Taiwan. (nih.gov)
  • This study evaluated the lipid abnormalities associated with different stages of albuminuria in type 2 diabetic patients. (nih.gov)
  • Causes of albuminuria can be discriminated between by the amount of protein excreted. (wikipedia.org)
  • Marios K. Georgakis, MD, from the University of Athens in Greece, and colleagues conducted a systematic review to examine the correlation between albuminuria and cognitive impairment, dementia, and cognitive function. (psychiatryadvisor.com)
  • medical citation needed] Nephritic syndrome results in far less albuminuria. (wikipedia.org)
  • Worse global cognitive performance and accelerated cognitive decline for subjects with albuminuria. (psychiatryadvisor.com)
  • The analysis shows that albuminuria is associated with an increased risk of cancer death, specifically for all-cause, lung, and prostate cancers in men ages 50 and above. (aacrjournals.org)
  • This graph shows the total number of publications written about "Albuminuria" by people in this website by year, and whether "Albuminuria" was a major or minor topic of these publications. (umassmed.edu)
  • They further adjusted for regression dilution to account for imprecision in the estimation of albuminuria at the participant level. (diabetesincontrol.com)