Albumins: Water-soluble proteins found in egg whites, blood, lymph, and other tissues and fluids. They coagulate upon heating.Serum Albumin: A major protein in the BLOOD. It is important in maintaining the colloidal osmotic pressure and transporting large organic molecules.Serum Albumin, Bovine: Serum albumin from cows, commonly used in in vitro biological studies. (From Stedman, 25th ed)Serum Albumin, Radio-Iodinated: Normal human serum albumin mildly iodinated with radioactive iodine (131-I) which has a half-life of 8 days, and emits beta and gamma rays. It is used as a diagnostic aid in blood volume determination. (from Merck Index, 11th ed)Receptors, Albumin: Cell surface proteins that bind albumin with high affinity and trigger intracellular changes influencing the behavior of cells.Technetium Tc 99m Aggregated Albumin: A gamma-emitting radionuclide imaging agent used for the diagnosis of diseases in many tissues, particularly in cardiovascular and cerebral circulation.Albuminuria: The presence of albumin in the urine, an indicator of KIDNEY DISEASES.Hypoalbuminemia: A condition in which albumin level in blood (SERUM ALBUMIN) is below the normal range. Hypoalbuminemia may be due to decreased hepatic albumin synthesis, increased albumin catabolism, altered albumin distribution, or albumin loss through the urine (ALBUMINURIA).2S Albumins, Plant: A major class of water-soluble seed storage proteins. Many proteins from this class are major PLANT ALLERGENS.Blood Proteins: Proteins that are present in blood serum, including SERUM ALBUMIN; BLOOD COAGULATION FACTORS; and many other types of proteins.Bromcresol Green: An indicator and reagent. It has been used in serum albumin determinations and as a pH indicator.Bilirubin: A bile pigment that is a degradation product of HEME.Capillary Permeability: The property of blood capillary ENDOTHELIUM that allows for the selective exchange of substances between the blood and surrounding tissues and through membranous barriers such as the BLOOD-AIR BARRIER; BLOOD-AQUEOUS BARRIER; BLOOD-BRAIN BARRIER; BLOOD-NERVE BARRIER; BLOOD-RETINAL BARRIER; and BLOOD-TESTIS BARRIER. Small lipid-soluble molecules such as carbon dioxide and oxygen move freely by diffusion. Water and water-soluble molecules cannot pass through the endothelial walls and are dependent on microscopic pores. These pores show narrow areas (TIGHT JUNCTIONS) which may limit large molecule movement.Liver: A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.Cattle: Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.Protein Binding: The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.alpha-Fetoproteins: The first alpha-globulins to appear in mammalian sera during FETAL DEVELOPMENT and the dominant serum proteins in early embryonic life.Plasma Volume: Volume of PLASMA in the circulation. It is usually measured by INDICATOR DILUTION TECHNIQUES.CreatinineDialysis: A process of selective diffusion through a membrane. It is usually used to separate low-molecular-weight solutes which diffuse through the membrane from the colloidal and high-molecular-weight solutes which do not. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Blood Protein Electrophoresis: Electrophoresis applied to BLOOD PROTEINS.Plasma Substitutes: Any liquid used to replace blood plasma, usually a saline solution, often with serum albumins, dextrans or other preparations. These substances do not enhance the oxygen- carrying capacity of blood, but merely replace the volume. They are also used to treat dehydration.Proteinuria: The presence of proteins in the urine, an indicator of KIDNEY DISEASES.Diabetic Nephropathies: KIDNEY injuries associated with diabetes mellitus and affecting KIDNEY GLOMERULUS; ARTERIOLES; KIDNEY TUBULES; and the interstitium. Clinical signs include persistent PROTEINURIA, from microalbuminuria progressing to ALBUMINURIA of greater than 300 mg/24 h, leading to reduced GLOMERULAR FILTRATION RATE and END-STAGE RENAL DISEASE.Kinetics: The rate dynamics in chemical or physical systems.Bromcresol Purple: An indicator and reagent. It has been used for several purposes including the determination of serum albumin concentrationsTime Factors: Elements of limited time intervals, contributing to particular results or situations.Nephelometry and Turbidimetry: Chemical analysis based on the phenomenon whereby light, passing through a medium with dispersed particles of a different refractive index from that of the medium, is attenuated in intensity by scattering. In turbidimetry, the intensity of light transmitted through the medium, the unscattered light, is measured. In nephelometry, the intensity of the scattered light is measured, usually, but not necessarily, at right angles to the incident light beam.Renal Dialysis: Therapy for the insufficient cleansing of the BLOOD by the kidneys based on dialysis and including hemodialysis, PERITONEAL DIALYSIS, and HEMODIAFILTRATION.Transferrin: An iron-binding beta1-globulin that is synthesized in the LIVER and secreted into the blood. It plays a central role in the transport of IRON throughout the circulation. A variety of transferrin isoforms exist in humans, including some that are considered markers for specific disease states.Kidney Failure, Chronic: The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION.Rabbits: The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.Biological Markers: Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.OrosomucoidSerum Globulins: All blood proteins except albumin ( = SERUM ALBUMIN, which is not a globulin) and FIBRINOGEN (which is not in the serum). The serum globulins are subdivided into ALPHA-GLOBULINS; BETA-GLOBULINS; and GAMMA-GLOBULINS on the basis of their electrophoretic mobilities. (From Dorland, 28th ed)Hydrogen-Ion Concentration: The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH = log 1/2[1/(H+)], where (H+) is the hydrogen ion concentration in gram equivalents per liter of solution. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Kidney: Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.Ultrafiltration: The separation of particles from a suspension by passage through a filter with very fine pores. In ultrafiltration the separation is accomplished by convective transport; in DIALYSIS separation relies instead upon differential diffusion. Ultrafiltration occurs naturally and is a laboratory procedure. Artificial ultrafiltration of the blood is referred to as HEMOFILTRATION or HEMODIAFILTRATION (if combined with HEMODIALYSIS).Kidney Glomerulus: A cluster of convoluted capillaries beginning at each nephric tubule in the kidney and held together by connective tissue.Rats, Inbred Strains: Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding.Colloids: Two-phase systems in which one is uniformly dispersed in another as particles small enough so they cannot be filtered or will not settle out. The dispersing or continuous phase or medium envelops the particles of the discontinuous phase. All three states of matter can form colloids among each other.Protein-Losing Enteropathies: Pathological conditions in the INTESTINES that are characterized by the gastrointestinal loss of serum proteins, including SERUM ALBUMIN; IMMUNOGLOBULINS; and at times LYMPHOCYTES. Severe condition can result in HYPOGAMMAGLOBULINEMIA or LYMPHOPENIA. Protein-losing enteropathies are associated with a number of diseases including INTESTINAL LYMPHANGIECTASIS; WHIPPLE'S DISEASE; and NEOPLASMS of the SMALL INTESTINE.Nephrotic Syndrome: A condition characterized by severe PROTEINURIA, greater than 3.5 g/day in an average adult. The substantial loss of protein in the urine results in complications such as HYPOPROTEINEMIA; generalized EDEMA; HYPERTENSION; and HYPERLIPIDEMIAS. Diseases associated with nephrotic syndrome generally cause chronic kidney dysfunction.Protein-Energy Malnutrition: The lack of sufficient energy or protein to meet the body's metabolic demands, as a result of either an inadequate dietary intake of protein, intake of poor quality dietary protein, increased demands due to disease, or increased nutrient losses.Adsorption: The adhesion of gases, liquids, or dissolved solids onto a surface. It includes adsorptive phenomena of bacteria and viruses onto surfaces as well. ABSORPTION into the substance may follow but not necessarily.Immunoglobulin G: The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.Hydroxyethyl Starch Derivatives: Starches that have been chemically modified so that a percentage of OH groups are substituted with 2-hydroxyethyl ether groups.Fibrinogen: Plasma glycoprotein clotted by thrombin, composed of a dimer of three non-identical pairs of polypeptide chains (alpha, beta, gamma) held together by disulfide bonds. Fibrinogen clotting is a sol-gel change involving complex molecular arrangements: whereas fibrinogen is cleaved by thrombin to form polypeptides A and B, the proteolytic action of other enzymes yields different fibrinogen degradation products.Nutritional Status: State of the body in relation to the consumption and utilization of nutrients.Fructosamine: An amino sugar formed when glucose non-enzymatically reacts with the N-terminal amino group of proteins. The fructose moiety is derived from glucose by the "classical" Amadori rearrangement.Glomerular Filtration Rate: The volume of water filtered out of plasma through glomerular capillary walls into Bowman's capsules per unit of time. It is considered to be equivalent to INULIN clearance.Low Density Lipoprotein Receptor-Related Protein-2: An LDL-RECEPTOR RELATED PROTEIN found in the neuroepithelium and in proximal tubular cells of the kidney. It is considered a multiligand receptor in that it binds to a variety of ligands with relatively high affinity and may function in mediating the uptake and lysosomal degradation of macromolecules such as: LIPOPROTEINS; ENDOPEPTIDASES; and PROTEASE INHIBITORS.Binding Sites: The parts of a macromolecule that directly participate in its specific combination with another molecule.Spectrometry, Fluorescence: Measurement of the intensity and quality of fluorescence.Biological Transport: The movement of materials (including biochemical substances and drugs) through a biological system at the cellular level. The transport can be across cell membranes and epithelial layers. It also can occur within intracellular compartments and extracellular compartments.Electrophoresis, Polyacrylamide Gel: Electrophoresis in which a polyacrylamide gel is used as the diffusion medium.Oleic Acids: A group of fatty acids that contain 18 carbon atoms and a double bond at the omega 9 carbon.Cells, Cultured: Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.Hematocrit: The volume of packed RED BLOOD CELLS in a blood specimen. The volume is measured by centrifugation in a tube with graduated markings, or with automated blood cell counters. It is an indicator of erythrocyte status in disease. For example, ANEMIA shows a low value; POLYCYTHEMIA, a high value.Rats, Sprague-Dawley: A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.Hypoproteinemia: A condition in which total serum protein level is below the normal range. Hypoproteinemia can be caused by protein malabsorption in the gastrointestinal tract, EDEMA, or PROTEINURIA.Proteins: Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.Urea: A compound formed in the liver from ammonia produced by the deamination of amino acids. It is the principal end product of protein catabolism and constitutes about one half of the total urinary solids.Radioimmunoassay: Classic quantitative assay for detection of antigen-antibody reactions using a radioactively labeled substance (radioligand) either directly or indirectly to measure the binding of the unlabeled substance to a specific antibody or other receptor system. Non-immunogenic substances (e.g., haptens) can be measured if coupled to larger carrier proteins (e.g., bovine gamma-globulin or human serum albumin) capable of inducing antibody formation.Reference Values: The range or frequency distribution of a measurement in a population (of organisms, organs or things) that has not been selected for the presence of disease or abnormality.Carbonates: Salts or ions of the theoretical carbonic acid, containing the radical CO2(3-). Carbonates are readily decomposed by acids. The carbonates of the alkali metals are water-soluble; all others are insoluble. (From Grant & Hackh's Chemical Dictionary, 5th ed)Fatty Acids: Organic, monobasic acids derived from hydrocarbons by the equivalent of oxidation of a methyl group to an alcohol, aldehyde, and then acid. Fatty acids are saturated and unsaturated (FATTY ACIDS, UNSATURATED). (Grant & Hackh's Chemical Dictionary, 5th ed)GlobulinsChromatography, High Pressure Liquid: Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.Perfusion: Treatment process involving the injection of fluid into an organ or tissue.Glycosylation End Products, Advanced: Products derived from the nonenzymatic reaction of GLUCOSE and PROTEINS in vivo that exhibit a yellow-brown pigmentation and an ability to participate in protein-protein cross-linking. These substances are involved in biological processes relating to protein turnover and it is believed that their excessive accumulation contributes to the chronic complications of DIABETES MELLITUS.Blood Chemical Analysis: An examination of chemicals in the blood.Evans Blue: An azo dye used in blood volume and cardiac output measurement by the dye dilution method. It is very soluble, strongly bound to plasma albumin, and disappears very slowly.Iodine Radioisotopes: Unstable isotopes of iodine that decay or disintegrate emitting radiation. I atoms with atomic weights 117-139, except I 127, are radioactive iodine isotopes.Kidney Diseases: Pathological processes of the KIDNEY or its component tissues.Fluorescein-5-isothiocyanate: Fluorescent probe capable of being conjugated to tissue and proteins. It is used as a label in fluorescent antibody staining procedures as well as protein- and amino acid-binding techniques.Kidney Tubules, Proximal: The renal tubule portion that extends from the BOWMAN CAPSULE in the KIDNEY CORTEX into the KIDNEY MEDULLA. The proximal tubule consists of a convoluted proximal segment in the cortex, and a distal straight segment descending into the medulla where it forms the U-shaped LOOP OF HENLE.Iodine Isotopes: Stable iodine atoms that have the same atomic number as the element iodine, but differ in atomic weight. I-127 is the only naturally occurring stable iodine isotope.Immunoelectrophoresis: A technique that combines protein electrophoresis and double immunodiffusion. In this procedure proteins are first separated by gel electrophoresis (usually agarose), then made visible by immunodiffusion of specific antibodies. A distinct elliptical precipitin arc results for each protein detectable by the antisera.Antibodies: Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).Peritoneal Dialysis: Dialysis fluid being introduced into and removed from the peritoneal cavity as either a continuous or an intermittent procedure.Ascites: Accumulation or retention of free fluid within the peritoneal cavity.Coloring Agents: Chemicals and substances that impart color including soluble dyes and insoluble pigments. They are used in INKS; PAINTS; and as INDICATORS AND REAGENTS.Hemoglobins: The oxygen-carrying proteins of ERYTHROCYTES. They are found in all vertebrates and some invertebrates. The number of globin subunits in the hemoglobin quaternary structure differs between species. Structures range from monomeric to a variety of multimeric arrangements.gamma-Globulins: Serum globulins that migrate to the gamma region (most positively charged) upon ELECTROPHORESIS. At one time, gamma-globulins came to be used as a synonym for immunoglobulins since most immunoglobulins are gamma globulins and conversely most gamma globulins are immunoglobulins. But since some immunoglobulins exhibit an alpha or beta electrophoretic mobility, that usage is in decline.RNA, Messenger: RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.Paracentesis: A procedure in which fluid is withdrawn from a body cavity or organ via a trocar and cannula, needle, or other hollow instrument.Thyroxine-Binding Proteins: Blood proteins that bind to THYROID HORMONES such as THYROXINE and transport them throughout the circulatory system.Dextrans: A group of glucose polymers made by certain bacteria. Dextrans are used therapeutically as plasma volume expanders and anticoagulants. They are also commonly used in biological experimentation and in industry for a wide variety of purposes.Rats, Wistar: A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.Lactoglobulins: Globulins of milk obtained from the WHEY.Permeability: Property of membranes and other structures to permit passage of light, heat, gases, liquids, metabolites, and mineral ions.Amino Acids: Organic compounds that generally contain an amino (-NH2) and a carboxyl (-COOH) group. Twenty alpha-amino acids are the subunits which are polymerized to form proteins.Malnutrition: An imbalanced nutritional status resulted from insufficient intake of nutrients to meet normal physiological requirement.Immunoassay: A technique using antibodies for identifying or quantifying a substance. Usually the substance being studied serves as antigen both in antibody production and in measurement of antibody by the test substance.Oleic Acid: An unsaturated fatty acid that is the most widely distributed and abundant fatty acid in nature. It is used commercially in the preparation of oleates and lotions, and as a pharmaceutical solvent. (Stedman, 26th ed)Cerebrospinal Fluid Proteins: Proteins in the cerebrospinal fluid, normally albumin and globulin present in the ratio of 8 to 1. Increases in protein levels are of diagnostic value in neurological diseases. (Brain and Bannister's Clinical Neurology, 7th ed, p221)Liver Neoplasms, Experimental: Experimentally induced tumors of the LIVER.Blood Protein DisordersAlpha-Globulins: Serum proteins that have the most rapid migration during ELECTROPHORESIS. This subgroup of globulins is divided into faster and slower alpha(1)- and alpha(2)-globulins.Binding, Competitive: The interaction of two or more substrates or ligands with the same binding site. The displacement of one by the other is used in quantitative and selective affinity measurements.Microspheres: Small uniformly-sized spherical particles, of micrometer dimensions, frequently labeled with radioisotopes or various reagents acting as tags or markers.Oxyphenbutazone: A non-steroidal anti-inflammatory drug. Oxyphenbutazone eyedrops have been used abroad in the management of postoperative ocular inflammation, superficial eye injuries, and episcleritis. (From AMA, Drug Evaluations Annual, 1994, p2000) It had been used by mouth in rheumatic disorders such as ankylosing spondylitis, osteoarthritis, and rheumatoid arthritis but such use is no longer considered justified owing to the risk of severe hematological adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p27)Hepatocytes: The main structural component of the LIVER. They are specialized EPITHELIAL CELLS that are organized into interconnected plates called lobules.Blood Pressure: PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.Nutrition Disorders: Disorders caused by nutritional imbalance, either overnutrition or undernutrition.

Isolation of rat liver albumin messenger RNA. (1/2483)

Rat liver albumin messenger RNA has been purified to apparent homogeneity by means of polysome immunoprecipitation and poly(U)-Sepharose affinity chromatography. Specific polysomes synthesizing albumin were separated from total liver polysomes through a double antibody technique which allowed isolation of a specific immunoprecipitate. The albumin-polysome immunoprecipitate was dissolved in detergent and the polysomal RNA was separated from protein by sucrose gradient centrifugation. Albumin mRNA was then separated from ribosomal RNA by affinity chromatography through the binding of poly(U)-Sepharose to the polyadenylate 3' terminus of the mRNA. Pure albumin mRNA migrated as an 18 S peak on 85% formamide-containing linear sucrose gradients and as a 22 S peak on 2.5% polyacrylamide gels in sodium dodecyl sulfate. It coded for the translation of authentic liver albumin when added to a heterologous protein-synthesizing cell-free system derived from either rabbit reticulocyte lysates or wheat germ extracts. Translation analysis in reticulocyte lysates indicated that albumin polysomes were purified approximately 9-fold from total liver polysomes, and that albumin mRNA was purified approximately 74-fold from albumin polysomal RNA. The total translation product in the mRNA-dependent wheat germ system, upon addition of the pure mRNA, was identified as authentic albumin by means of gel electrophoresis and tryptic peptide chromatography.  (+info)

Sentinel lymph node biopsy and axillary dissection in breast cancer: results in a large series. (2/2483)

BACKGROUND: Axillary lymph node dissection is an established component of the surgical treatment of breast cancer, and is an important procedure in cancer staging; however, it is associated with unpleasant side effects. We have investigated a radioactive tracer-guided procedure that facilitates identification, removal, and pathologic examination of the sentinel lymph node (i.e., the lymph node first receiving lymphatic fluid from the area of the breast containing the tumor) to predict the status of the axilla and to assess the safety of foregoing axillary dissection if the sentinel lymph node shows no involvement. METHODS: We injected 5-10 MBq of 99mTc-labeled colloidal particles of human albumin peritumorally in 376 consecutive patients with breast cancer who were enrolled at the European Institute of Oncology during the period from March 1996 through March 1998. The sentinel lymph node in each case was visualized by lymphoscintigraphy, and its general location was marked on the overlying skin. During breast surgery, the sentinel lymph node was identified for removal by monitoring the acoustic signal from a hand-held gamma ray-detecting probe. Total axillary dissection was then carried out. The pathologic status of the sentinel lymph node was compared with that of the whole axilla. RESULTS: The sentinel lymph node was identified in 371 (98.7%) of the 376 patients and accurately predicted the state of the axilla in 359 (95.5%) of the patients, with 12 false-negative findings (6.7%; 95% confidence interval = 3.5%-11.4%) among a total of 180 patients with positive axillary lymph nodes. CONCLUSIONS: Sentinel lymph node biopsy using a gamma ray-detecting probe allows staging of the axilla with high accuracy in patients with primary breast cancer. A randomized trial is necessary to determine whether axillary dissection may be avoided in those patients with an uninvolved sentinel lymph node.  (+info)

"The FSGS factor:" enrichment and in vivo effect of activity from focal segmental glomerulosclerosis plasma. (3/2483)

A circulating causative factor has been postulated in focal segmental glomerulosclerosis (FSGS). It has been shown that serum or plasma from some FSGS increases glomerular albumin permeability (Palb) in vitro. Palb greater than 0.5 (i.e., FS activity) is associated with recurrence after transplantation. Specimens from 15 FSGS patients were studied to document the presence of a permeability factor, to isolate this factor, to characterize its biochemical properties, and to show its effect in vivo. Total lipids were extracted by chloroform/methanol (2: 1); FS activity was absent from total lipid extract. Chylomicrons and lipoproteins were removed from the plasma with dextran sulfate, followed by sequential precipitation of proteins at 50 and 70% ammonium sulfate saturation. FS activity was retained in the 70% ammonium sulfate supernatant and exhibited a 100-fold purification. FS activity was lost after heating at 100 degrees C for 10 min or after protease digestion. Under nondenaturing conditions, electrophoresis of the FSGS 70% supernatant showed a prominent low molecular weight band that was not evident in the 70% supernatant from normal plasma. Dialysis and centrifugation-based membrane ultrafiltration of the FSGS factor indicated a molecular size between 30 and 50 kD. Injection of the 70% FSGS supernatant into rats caused a threefold increase in urine protein in collections from 6 to 24 h after injection. No increase in proteinuria occurred in rats injected with 70% supernatant from normal individuals. It is concluded that the FSGS factor is a low molecular weight protein with the potential to increase Palb in vitro and to cause proteinuria in vivo.  (+info)

Triacylglycerol biosynthesis in rat adipose-tissue homogenates. (4/2483)

The optimum cofactor requirements for triacylglycerol biosynthesis in rat adipose-tissue homogenates containing mitochondrial, microsomal and cytosolic fractions were investigated. In general the optimum concentrations of cofactors for triacylglycerol biosynthesis were found to differ from those for total fatty acid esterification. The results provided further evidence for the key role of phosphatidate phosphohydrolase in the regulation of triacylglycerol biosynthesis. Albumin was included in the incubation medium to permit the use of concentrations of added fatty acids that would swamp the effects of endogenous fatty acids. The addition of albumin had little effect on the incorporation of palmitic acid and stearic acid into lipids including triacylglycerols. By contrast, a critical concentration of albumin (about 60 muM) was required before incorporation of oleic acid or linoleic acid into triacylglycerols occurred. The system was used to study the incorporation of different 1-14C-labelled fatty acids from a mixture of unesterified fatty acids [palmitic acid 30%; stearic acid 10%; oleic acid 40%; linoleic acid 20% (molar percentages)] separately into the positions 1,2 and 3 of triacyl-sn-glycerols. In general the stereo-specific distribution of the labelled fatty acids incorporated into triacylglycerols paralleled the normal distribution of fatty acids within rat adipose-tissue triacylglycerols, suggesting that the specificities of the relevant acyltrasferases have the major role in determining the positional distribution of fatty acids within triacylglycerols.  (+info)

von Willebrand factor contained in a high purity FVIII concentrate (Fanhdi) binds to platelet glycoproteins and supports platelet adhesion to subendothelium under flow conditions. (5/2483)

BACKGROUND AND OBJECTIVE: There is evidence suggesting that von Willebrand factor (VWF) from high purity factor VIII concentrates could be of clinical use in the management of patients suffering from VWD. We analyzed structural and functional characteristics of VWF present in a high purity factor VIII concentrate VWFHPC (Fanhdi). The multimeric structure, the ability to bind to platelet GP Ib/IX or GP IIb/IIIa, and the capacity of VWFHPC to promote platelet adhesion on injured vessels were investigated and compared with that present in standard plasma cryoprecipitates [VWFCRYO]. DESIGN AND METHODS: Binding studies were carried out by incubating radiolabeled VWF and washed platelets, which were activated with either ristocetin (1 mg/mL; for GP Ib/IX), or thrombin (2.5 U/mL; for GP IIb/IIIa). Platelet adhesion was assessed in a perfusion system (shear rate = 800 s-1, 10 min) in which the source of VWF was added (at 0.4 or 0.8 U/mL VWF:Ag) to washed platelets and red cells suspended in a human albumin solution. The deposition of platelets onto the perfused subendothelial surface was morphometrically evaluated and expressed as percentage of surface coverage (%SC). RESULTS: The VWFHPC (152 Units VWF:RCof/mg protein; VWF:RCof/VWF:Ag = 0.97), lacked only a small proportion of high-molecular-weight multimers present in VWFCRYO. Binding affinities (Kd values, nM) of VWFHPC were similar to those of VWFCRYO (5.3 +/- 0.86 vs 5.2 +/- 0.95, for GP Ib/IX; and 11.6 +/- 2.7 vs 15.4 +/- 1.7 for GPIIb-IIIa). A slightly, though not significantly, higher binding capacity for these receptors (Bmax values, molecules/pit) was obtained for VWFHPC. The %SC in perfusions in the presence of albumin was < 10%. Addition of VWFHPC or VWFCRYO significantly increased the %SC, with values of 27.1 +/- 4.9 and 17.5 +/- 2.8%, respectively with 0.4 U/mL (p < 0.004 and p < 0.02 vs albumin); and 30.8 +/- 4.9% and 20.03 +/- 4.1%, respectively, at 0.8 U/mL (p < 0.001 and p < 0.02 vs albumin). INTERPRETATION AND CONCLUSIONS: Our data show that VWF present in the high purity FVIII concentrate Fanhdi retains the functional capacity to bind to GPs Ib/IX and IIb/IIIa and to promote platelet adhesion onto exposed subendothelium.  (+info)

Secretory cells of the peripheral pulmonary epithelium as targets for toxic agents. (6/2483)

The extracellular lining of the pulmonary peripheral airways is of vital importance to the lung. In this report, some aspects of the pulmonary extracellular lining and the epithelial cells believed to be responsible for its formation and secretion have been briefly reviewed. The influence of a number of toxic agents on the extracellular lining either directly or via those cells involved in its formation indicates that the extracellular lining may be important in understanding numerous toxic agent interactions with the lung.  (+info)

Peritoneal clearance of leptin in CAPD patients: impact of local insulin administration. (7/2483)

INTRODUCTION: The ob gene product leptin is secreted by fat cells and the serum leptin levels reflects the body fat content. Markedly elevated serum leptin levels have been reported in patients with chronic renal failure. The aim of the present study was to assess if the dialysate leptin levels in peritoneal dialysate are similar to what can be expected from passive diffusion or if intraperitoneal synthesis of leptin may occur. METHODS: We studied 39 patients (20 males), mean age 54+/-12 years, who had been treated with peritoneal dialysis for 17+/-12 months. Ten of the patients were diabetics of which seven used intraperitoneal insulin. A 24-h collection of dialysate was performed and dialysate and fasting blood samples were analysed for leptin, albumin and beta2-microglobulin, and the peritoneal clearances (PCl) were calculated for these solutes. RESULTS: Serum leptin (mean 47+/-76, range 3-350 ng/ml) was related to body mass index (r=0.35, P<0.05). In multiple regression analysis, serum leptin also correlated to serum TNF-alpha. Although dialysate leptin levels correlated to serum leptin, they were higher than expected from the molecular weight of 16 kD. PCl of leptin was 1.3 ml/min (range 0.2-5.9 ml/min), which was 1.6 times higher than expected from the molecular weight of leptin and PCl for albumin and beta2-microglobulin, not taking the protein binding of leptin into account. A strong correlation was found between PCI for albumin and beta2-microglobulin (r = 0.68, P < 0.0001) but neither PCl albumin, nor PCl beta2-microglobulin correlated to PCI leptin. The PCl of leptin was markedly higher in diabetics using intraperitoneal insulin (n = 7) compared to the other 32 patients (2.6+/-2.0 vs 1.1+/-0.7 ml/min, P<0.05). CONCLUSION: Serum leptin is locally produced in the peritoneal cavity, and intraperitoneal insulin enhances local production of leptin.  (+info)

The cytotoxicity of mafosfamide on G-CSF mobilized hematopoietic progenitors is reduced by SH groups of albumin--implications for further purging strategies. (8/2483)

The efficacy of mafosfamide purging depends on factors like incubation time, drug and erythrocyte concentration. To determine the influence of protein-bound SH groups in the incubation medium, the cytotoxicity of mafosfamide on G-CSF mobilized CD34+/- cells was evaluated by short-term culture assays and drug concentration measurements. 100 micromol/ml mafosfamide was incubated for 30 min in five buffers (PBS, PBS with 1%, 5% and 10% BSA and plasma). The mean calculated areas under the concentration-time curves (AUC) were 2489 +/- 198, 1561 +/- 286, 976 +/- 201, 585 +/- 62 and 605 +/- 196 micromol/l/min. The mean reductions of CFU-GM growth were 79.4%, 73.0%, 62.5%, 30.3%, 6.2% respectively. Similar results were obtained for BFU-E. Regression analysis showed a good correlation between cytotoxicity and AUCs (CFU-GM: r = 0.8195; BFU-E: r = 0.8207). This effect is well explained by the different concentrations of SH moieties in the incubation medium resulting in a higher drug binding capacity. The profound difference between AUCs and CFU-GMs in plasma and 10% BSA cannot be explained by the quantity of SH-groups. It is probably due to an additional enzymatic drug degeneration by the 3'-5'exonuclease subsite of plasma DNA polymerase. In conclusion, the concentration of albumin-associated SH groups strongly influences the cytotoxicity of mafosfamide. It has to be considered as a new and important aspect in ex vivo bone marrow purging.  (+info)

The purpose of this trial is to determine the benefit of the combination of nab-paclitaxel plus gemcitabine given for 6 cycles, followed by maintenance
Japans largest platform for academic e-journals: J-STAGE is a full text database for reviewed academic papers published by Japanese societies
Abraxane use in ovarian cancer, abraxane with tykerb, abraxane billing code, abraxane blood brain barrier and abraxane oncology. Abraxane carboplatin, abraxane mixing, abraxane 2008 sales and abraxane gradishar or abraxane cost.
The use of hyperoncotic albumin (HA) for shock resuscitation is controversial given concerns about its cost, effectiveness, and potential for nephrotoxicity. We evaluated the association between early exposure to hyperoncotic albumin (within the first 48 h of onset of shock) and acute organ dysfunction in post-surgical patients with shock. This retrospective, cohort study included 11,512 perioperative patients with shock from 2009 to 2012. Shock was defined as requirement for vasopressors to maintain adequate mean arterial pressure and/or elevated lactate (| 2.2 mmol/L). Subsets of 3600 were selected after propensity score and exact matching on demographics, comorbidities, and treatment variables (| 30). There was a preponderance of cardiac surgery patients. Proportional odds logistic regression, multivariable logistic regression or Cox proportional hazard regression models measured association between hyperoncotic albumin and acute kidney injury (AKI), hepatic injury, ICU days, and mortality.
OBJECT: Human albumin is used to induce hypervolemia (central venous pressure [CVP] , 8 mm Hg) after subarachnoid hemorrhage (SAH). Unfortunately, human albumin may increase the mortality rate in critically ill patients; because of this, its use became restricted in the authors hospital in May 1999. The goal of this study was to determine the effect of human albumin on outcome and cost in patients with SAH before and after this restriction was put into place. METHODS: All patients with aneurysmal SAH who were admitted to the authors institution between May 1998 and May 2000 were studied. Basic demographic information, dosage of human albumin given, length of stay, and the incidence of in-hospital deaths and complications were collected. The authors obtained Glasgow Outcome Scale (GOS) scores at 3 months after SAH (good outcome, GOS , or = 4). Data were analyzed using t-test and chi-square analysis. Logistic regression was used to identify independent associations between use of human albumin ...
5438 Background: Docetaxel (Taxotere) is currently formulated in the surfactant Tween 80. Removal of surfactants from taxane formulations e.g., in the case of nanoparticle albumin-bound paclitaxel (Abraxane) resulted in significantly higher response rates and greater safety (Gradishar, JCO, 2005, 23:7794). Tween 80 strongly inhibited the binding of taxanes to albumin, possibly inhibiting albumin based drug transport via the gp60 endothelial receptor (Desai, EORTC-NCI-AACR, 2004) and consequent reduction of albumin-binding to tumor secreted SPARC. Herein, we compared the efficacy, toxicity, and pharmacokinetics (PK) of nab-docetaxel vs Taxotere. Methods: Nanoparticle nab-docetaxel was prepared using nab technology and characterized. Nab-docetaxel and Taxotere were tested in vivo against HCT-116 human colon carcinoma xenograft in nude mice (n=10/group) at equitoxic doses of 22 mg/kg of nab-docetaxel and 15 mg/kg of Taxotere, on a q4dx3 schedule. Single dose toxicity (TOX) of nab-docetaxel was ...
article{8d460a00-2713-4df9-af4f-6169013fd070, author = {Bakoush, Omran and Tencer, Jan and Torffvit, Ole and Tenstad, Olav and Skogvall, Ingela and Rippe, Bengt}, issn = {1460-2385}, language = {eng}, number = {7}, pages = {1724--1731}, publisher = {Oxford University Press}, series = {Nephrology Dialysis Transplantation}, title = {Increased glomerular albumin permeability in old spontaneously hypertensive rats.}, url = {http://dx.doi.org/10.1093/ndt/gfh276}, volume = {19}, year = {2004 ...
Preclinical studies have recently shown that albumin has neuroprotective effects for stroke in animal models. Thus, we sought to evaluate the effects of albumin therapy in patients with acute cerebral infarcts. We prospectively studied 49 patients with moderate-to-severe cerebral infarcts within the middle cerebral arterial territory into one of two groups: the control group (N = 18) received saline, whereas the albumin group (N = 31) received either 40 g or 80 g of albumin within 24 h from symptom onset.. The modified National Institutes of Health Stroke Scale (mNIHSS) and diffusion-weighted imaging (DWI) were serially checked. There was no adverse effect related to albumin therapy. Although there was no significant difference in both baseline mNIHSS score and DWI lesion volume on admission, the mNIHSS scores at the 14(th) day after treatment and the increase in DWI lesion volume 72-96 h after treatment were significantly reduced in patients of the albumin group (p = 0.001 and 0.012, ...
[126 Pages Report] Check for Discount on Global Albumin-based Sealants Sales Market Report 2016 report by QYResearch Group. Notes: Sales, means the sales volume of Albumin-based Sealants...
Purpose: Circulating Tumor cells (CTC) are prognostic in metastatic breast cancer (MBC). We tested whether EpCAM based capture system (CellSearch®) is effective in patients with triple negative (TN) MBC, and whether CTC-apoptosis and clustering enhances the prognostic role of CTC. Experimental Design: CTC enumeration and apoptosis was determined using the CXC CellSearch® kit at baseline and days 15 and 29 in blood drawn from TN MBC patients who participated in a prospective randomized phase II trial of nanoparticle albumin-bound paclitaxel (nab-PAC) with or without tigatuzumab (TIG). Association between levels of CTC and patient outcomes was assessed using logistic regression, Kaplan Meier curves, and Cox proportional hazards modeling. Results: Nineteen of 52 (36.5%), 14/52 (26.9%), and 13/49 (26.5%) patients who were evaluable had elevated CTC (≥5CTC/7.5 ml WB) at baseline, days 15 and 29, respectively. Patients with elevated vs. not elevated CTC at each time point had worse progression ...
this section was added after the table:. Description of selected adverse reactions Blood and lymphatic system disorders. Neutropenia was the most notable important haematological toxicity (reported in 79% of patients), and was rapidly reversible and dose dependent; leukopenia was reported in 71% of patients. Grade 4 neutropenia (, 0.5 x 109/l) occurred in 9% of patients treated with Abraxane. Febrile neutropenia occurred in four patients on Abraxane. Anaemia (Hb , 10 g/dl) was observed in 46% of patients on Abraxane, and was severe (Hb , 8 g/dl) in three cases. Lymphopenia was observed in 45% of the patients.. Nervous system disorders In general, the frequency and severity of neurotoxicity was dose‑dependent in patients receiving Abraxane. Peripheral neuropathy (mostly Grade 1 or 2 sensory neuropathy) was observed in 68% of patients on Abraxane with 10% being Grade 3, and no cases of Grade 4.. Gastrointestinal disorders Nausea occurred in 29% of the patients and diarrhoea in 25% of the ...
Pancreatic cancer is a hypoperfused tumor, characterized by a high stroma density precluding cytotoxics delivery to the epithelial tumoral compartment. There is thus a rationale for combining chemotherapy and antistromal drugs like nab-paclitaxel (Abraxane), a solvent (Cremophor® EL)-free, albumin-bound form of paclitaxel that has been initially developed to reduce the toxicities associated with Taxol injection while maintaining or improving its chemotherapeutic effect. This unique protein formulation provides a novel approach of increasing intra-tumoral concentrations of the drug by a receptor-mediated transport process allowing transcytosis across the endothelial cell.. Abraxane has been approved for commercialization in 38 countries, including the US, Canada, the EU, Australia, China, India and Korea for the treatment of women with metastatic breast cancer. Abraxane alone and in combination is being evaluated in a number of cancers, including metastatic melanoma, non-small cell lung cancer, ...
Biocon Limited, Indias pioneering biotechnology company, and Abraxis BioScience, Inc. (NASDAQ:ABII), a fully integrated biotechnology company, today announced the launch of ABRAXANE(R) (paclitaxel protein-bound particles for injectable suspension) (albumin-bound) in India for the treatment of breast cancer after failure of combination therapy for metastatic disease or relapse within six months of adjuvant chemotherapy. ABRAXANE is now available in India as a single-use 100 mg vial (as a lyophilized powder, to be reconstituted for intravenous administration). In October 2007, ABRAXANE was approved by the Drug Controller General of India. The approval was based on the clinical trial data that was the basis of approval in the United States. The Phase III clinical trial in the U.S. demonstrated that ABRAXANE nearly doubled the response rate, significantly prolonged time to progression, and significantly improved overall survival in the second-line setting versus solvent-based Taxol(R) in the ...
Introduction- Exercise-induced plasma volume (PV) expansion is typically associated with an increase in plasma albumin content. Increased hepatic albumin synthesis, a transcriptionally regulated process, is thought to contribute to the increase in albumin content. Objective- We tested the hypothesis that exercise training induces an increase in albumin gene expression in relationship to the increase in PV. Methods and Results- 40 adult male Sprague-Dawley rats weighing between 245-350 grams were randomly assigned to one of four groups: cage control (CC); sham exercise 10 min/day at 48% VO2max (NE); continuous exercise training, 60 min /day at 72% VO2max (LI); and high intensity, intermittent exercise training, 8 bouts of 4 min at 98% VO2max followed by 5 min at 48% VO2max (HI). The training period lasted for two weeks with 12 training sessions with equalized training volumes in the exercise groups. 24 hours after the last training session the rats were anesthetized and a jugular catheter was placed for
Decreased albumin synthesis by hepatocytes in liver injury is thought to occur in response to Kupffer cell-derived acute-phase cytokines. In this study we used hepatocytes maintained in a differentiated phenotype, by culture on a laminin-rich gel substratum (Engelbreth-Holm-Swarm matrix), to investigate the effects of Kupffer cell-conditioned medium and purified cytokines (interleukin-1, interleukin-6 and tumor necrosis factor-a) on albumin synthesis. Kupffer cell-conditioned medium caused a reversible decrease in albumin synthesis to 64.7% of control (p , 0.01, Wilcoxons rank sum test, n = 11) on day 2. Repeated doses caused further dose-dependent reversible responses. The same result was obtained when protease inhibitors (α1-antitrypsin and α2-macroglobulin) were added to Kupffer cell-conditioned medium (n = 3), thus eliminating the potential effect of matrix degradation. Pure interleukin-1, interleukin-6 and tumor necrosis factor-α also inhibited albumin synthesis (p , 0.05, Wilcoxons ...
The phase III clinical trials in the US and China on which this approval was based demonstrated that Abraxane doubled the response rate, significantly prolonged time to tumour progression, and in the US trial, significantly improved overall survival versus Taxol in the approved indication.. Data from the US pivotal head-to-head trial demonstrated that Abraxane nearly doubled the overall response rate versus Taxol (33% vs. 19%; P = .001) and achieved a 25% percent improvement in time to tumour progression when compared to Taxol. Furthermore, patients receiving Abraxane in the second-line setting had a significantly prolonged survival by an additional 27% compared to solvent-based Taxol. The tolerability with Abraxane and Taxol was comparable, despite the 50% greater dose of paclitaxel administered as Abraxane.. A second head-to-head trial in Chinese patients with metastatic breast cancer further demonstrated the improved efficacy of Abraxane compared to solvent-based Paclitaxel Injection. ...
Next article in issue: Detection of albumin messenger RNA in blood is not restricted to hepatocellular carcinoma Next article in issue: Detection of albumin messenger RNA in blood is not restricted to hepatocellular carcinoma ...
Abraxane® (nab-paclitaxel) prolonged life in patients with metastatic pancreatic cancer by an average of two months longer than chemotherapy and significantly increased the percentage of patients who survived for up to two years, according to the results of a study presented at the 2013 Gastrointestinal Cancers Symposium in San Francisco.. Pancreatic cancer is one of the deadliest forms of cancer. Each year, approximately 43,000 people are diagnosed with pancreatic cancer in the United States and close to 37,000 die from the disease. The disease is often diagnosed at an advanced stage, and treatment of advanced disease remains challenging.. Gemzar® (gemcitabine) has been a standard chemotherapy drug for the treatment of advanced pancreatic cancer for some time. Abraxane is a novel form of the widely used cancer drug Taxol (paclitaxel). In Abraxane, the paclitaxel is bound to albumin, a human protein in tiny particles. This formulation improves the delivery of the drug directly to cancer cells ...
Rabbit plasma albumin was labelled with I131, injected intravenously, and measurements were made of the radioactivity in plasma, urine, and feces over many days. In some experiments plasma radioactivity was fractionated into I131-albumin activity and that of labelled breakdown products. Curves of these radioactivities were compared with corresponding curves predicted by four mathematical models. Each model included a vascular and extravascular albumin compartment in transfer equilibrium, a radioactive breakdown products compartment, and an excretion compartment; but model A supposed I131-albumin catabolism to occur within the vascular system, model B within the extravascular compartment, model C within both, and model D within a separate compartment receiving albumin for catabolism from the plasma. The experimental data were reasonably well predicted by models A and C. However, model D, though data were insufficient for its complete validation, gave the best predictions and agrees with present ...
TY - JOUR. T1 - Treatment Rationale and Design for J-AXEL. T2 - A Randomized Phase 3 Study Comparing Nab-Paclitaxel With Docetaxel in Patients With Previously Treated Advanced Non-Small-Cell Lung Cancer. AU - Yoneshima, Yasuto. AU - Morita, Satoshi. AU - Ando, Masahiko. AU - Miura, Satoru. AU - Yoshioka, Hiroshige. AU - Abe, Tetsuya. AU - Kato, Terufumi. AU - Kondo, Masashi. AU - Hosomi, Yukio. AU - Hotta, Katsuyuki. AU - Yamamoto, Nobuyuki. AU - Kishimoto, Junji. AU - Nakanishi, Yoichi. AU - Okamoto, Isamu. PY - 2017/1/1. Y1 - 2017/1/1. N2 - Background Nanoparticle albumin-bound (nab) paclitaxel is a promising new therapeutic agent for all histologic types of non-small-cell lung cancer (NSCLC). We recently performed a phase 2 study of weekly nab-paclitaxel in patients with previously treated advanced NSCLC, finding promising activity and acceptable toxicity for this regimen. We have now designed a randomized phase 3 intergroup study (J-AXEL, UMIN000017487) to examine the clinical benefit and ...
The review by Wilkes and Navickis is the 13th meta-analysis evaluating the effect of fluids on mortality in seriously ill patients. The strengths of this meta-analysis are the comprehensive search strategies used to identify primary studies, which minimised publication and English language bias; the explicit selection criteria used; the use of methodological quality, such as random assignment, as an inclusion criterion; extraction of data in duplicate; and rating of treatment allocation, crossovers, and blinding for each included study. However, all relevant co-interventions, such as blood products, were not well reported in the original trials. 23 of 78 potentially eligible studies were excluded because no mortality data were available, highlighting how many trials were designed to address short term physiological endpoints.. In this meta-analysis, the relative risk (RR) of mortality for all patients was 1.11 (table⇑). Subgroup analyses were planned a priori, and included surgery or trauma ...
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details ...
Roche (SIX: RO, ROG; OTCQX: RHHBY) today announced that the European Medicines Agencys (EMA) Committee for Medicinal Products for Human Use (CHMP) has adopted a positive opinion for Tecentriq® (atezolizumab) in combination with chemotherapy (carboplatin and Abraxane® [albumin-bound paclitaxel; nab-paclitaxel]), for the initial (first-line) treatment of adults with metastatic non-squamous non-small cell lung cancer (NSCLC) who do not have EGFR mutant or ALK-positive NSCLC. This decision is based on results from the Phase III IMpower130 study, which demonstrated that the Tecentriq combination therapy helped people live significantly longer, compared with chemotherapy alone (median overall survival [OS]=18.6 versus 13.9 months; hazard ratio [HR]=0.79; 95% CI: 0.64-0.98; p=0.033) in the intention-to-treat (ITT) population.1 The Tecentriq-based combination also significantly reduced the risk of disease worsening or death (progression-free survival, PFS) compared with chemotherapy alone (median ...
Gentaur molecular products has all kinds of products like :search , AbD \ RABBIT ANTI MOUSE ALBUMIN, Product Type Polyclonal Antibody, Specificity ALBUMIN, Target Species Mouse, Host Rabbit, Format Serum, Isotypes Polyclonal IgG, Applications ID, WB, Clone \ 0220-1829 for more molecular products just contact us
Buy EVOEGG 2.0 (EGG ALBUMIN) Online.Egg albumin protein, suitable for vegetarians100% egg white albumin from free hensHigh protein content, 25g per serving!Without fillers or amino spiking
Thank you for your interest in spreading the word about Biochemical Journal.. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.. ...
Although gemcitabine exhibits potent cytotoxicity against PDA cells in vitro, its short half-life may contribute to its relatively weak antitumor activity in vivo. Indeed, methods that increase gemcitabine delivery (3) or stability (22) have been proposed to circumvent this problem clinically. Taxanes are also active in pancreatic cancer xenografts and patients, although treatment is limited by systemic toxicity (23, 24). nab-Paclitaxel is a solvent-free formulation composed of paclitaxel and human albumin with a mean particle size of 130 nm. It offers several advantages over solvent-based paclitaxel, including increased water solubility that obviates Cremophor EL-based toxicities. In addition, albumin is hypothesized to target paclitaxel to stromal-rich tumors and thereby increase the local concentration. Although combinations of gemcitabine and taxanes have demonstrated antitumor activity in patients with PDA, its toxicity has limited its use in the clinic (25). Accumulating clinical data ...
The Therapeutic Goods Administration (TGA) has taken steps today to quarantine CSL Human Albumin solutions from further use while an asse
Relationship between ischemia/reperfusion-induced albumin clearance across the mucosa of the small intestine and the reduction in oxygen consumption induced during the ischemic period. Used with permission from Gastroenterology 1985; 89: pp. 852-857.
The anatomy of PFO suggests that it can allow thrombi and potentially harmful circulatory factors to travel directly from the venous to the arterial circulation - altering circulatory phenotype. Our previous publication using high-resolution LC-MS/MS to profile protein and peptide expression patterns in plasma showed that albumin was relatively increased in donor samples from PFO-related than other types of ischemic strokes. Since albumin binds a host of molecules and acts as a carrier for lipoproteins, small molecules and drugs, we decided to investigate the albumin-bound proteins (in a similar sample cohort) in an effort to unravel biological changes and potentially discover biomarkers related to PFO-related stroke and PFO endovascular closure. The method used in this study combined albumin immuno-enrichment with high resolution LC-MS in order to specifically capture and quantify the albumin-bound proteins. Subsequently, we measured cholesterol and HDL in a larger, separate cohort of PFO stroke
albumin - MedHelps albumin Center for Information, Symptoms, Resources, Treatments and Tools for albumin. Find albumin information, treatments for albumin and albumin symptoms.
Gentaur molecular products has all kinds of products like :search , Nordic Immunological Lab \ rabbit IgG against mouse albumin, conjugated with Biotin \ RAM/Alb/Bio for more molecular products just contact us
TY - JOUR. T1 - Macromolecule uptake into the cultured endothelial cells and the cell morphology in separated flow. AU - Kudo, Susumu. AU - Sato, Masashi. AU - Machida, Kazutoshi. AU - Yamaguchi, Ryuhei. AU - Kurokawa, Motoyoshi. AU - Matsuzawa, Teruo. AU - Ikeda, Mariko. AU - Oka, Kotaro. AU - Tanishita, Kazuo. PY - 1999/11. Y1 - 1999/11. N2 - One purpose of this study is to investigate the morphological change of endothelial cells in a separated flow area. The other is to reveal the albumin uptake into endothelial cells, the albumin uptake area, and the its content per unit area in the separated flow area. After 24 hr of exposure to flow induced in a back step flow channel, the endothelial cells were incubated in 37°C for 60 minutes in PBS containing tetramethylrhodamine isothiocyanate conjugated albumin (TRITC-albumin). Thereafter, the cell morphology, the density, and the albumin uptake were observed by a confocal laser scanning microscope (CLSM). In low shear stress areas (stagnant and ...
The National Institute for Health and Care Excellence has published new recommendations rejecting the use of Celgene’s Abraxane (nab-paclitaxel) on the National Health Service to treat patients with advanced pancreatic cancer. - News - PharmaTimes
This trial will investigate the efficacy and tolerability of everolimus [RAD001] and paclitaxel [Abraxane] in women with locally advanced or metastatic breast
Nexus Lifecare Pvt. Ltd. manufacturers, suppliers of anticancer drugs and anti cancer injections, Reditux Injection, Sorafenib, Herclon 440mg Injection, Abraxane 100mg Injection, Velcade Injection, Taxol injections, Kemocarb Injections, Lipodox injections in Mumbai.
Paclitaxel, Abraxane monotherapy is indicated for the treatment of metastatic breast cancer in adult patients who have failed first-line treatment for metastatic disease and for whom standard, anthracycline co
Phase II LAPACT trial results reported on the safety and efficacy of ABRAXANE + gemcitabine induction therapy on tumor burden, disease control, and symptoms SUMMIT, N.J.--(BUS...
Sorry for this but I feel I should ask a different question related to my other Thread. Here it is: Is anyone here aware of an insurance company refusing to cover Abraxane for Stage IV Pancreatic Cancer based in whether it was to be the first or second treatment?
Approval Based on MPACT Study of ABRAXANE in Combination with Gemcitabine Demonstrating a Clinically Meaningful Increase in Overall Survival-. -First New Treatment Approved for Metastatic Adenocarcinoma of the Pancreas in Nearly 8 Years-Continue reading→. ...
Abraxane in Tamil - ன் பயன்பாடுகள், மருந்தளவு, பக்க விளைவுகள், நன்மைகள், தொடர்புகள் மற்றும் எச்சரிக்கைகள் ஆகியவற்றை கண்டுபிடியுங்கள்.
Renal failure commonly develops in the setting of SBP, and its development is a sensitive predictor of in-hospital mortality. The renal impairment is thought to stem from decreased effective arterial blood volume secondary to the systemic inflammatory response to the infection. In our current practice, there are certain circumstances in which we administer albumin early in the SBP disease course in order to reduce the risk of renal failure and mortality. Ultimately, our current protocol originated from the 1999 study of albumin in SBP by Sort et al.. The trial enrolled adults with SBP and randomized them to treatment with either cefotaxime and albumin infusion 1.5 gm/kg within 6hrs of enrollment, followed by 1 gm/kg on day 3 or cefotaxime alone. The primary outcome was the development of "renal impairment" (a "nonreversible" increase in BUN or Cr by more than 50% to a value greater than 30 mg/dL or 1.5 mg/dL, respectively) during hospitalization. The secondary outcome was in-hospital ...
Our site contains links to third-party Web sites. We have no influence whatsoever on the information on these Web sites and accept no guaranty for its correctness. The content of such third-party sites is the responsibility of the respective owners/providers. At the time third-party Web sites were linked to ours, we found NO GROUNDS WHATSOEVER of any likely contravention of the law. We shall promptly delete a link upon becoming aware that it violates the law ...
Kaplan-Meier plots of overall survival in the full analysis set of patients with unresectable or recurrent gastric cancer receiving nanoparticle albumin-bound
BSA, or bovine serum albumin, has a molecular weight of 66 kilodaltons. BSA is a serum albumin protein that is derived from cows. This protein is utilized in research laboratories as a protein...
Unscramble ALBUMIN. Words with ALBUMIN unscrambled into word lists. Unscrambling ALBUMIN to anagrams made from letters. Word unscrambler rearranges scrambled letters to words.
Urine albumin trace - Hi my mom just did a nlood test and the results are HDL 35 Mg/dl LDL 103Mg/dl Albumin (+) (traces in urine) Are they related in some way please help? No. The results of cholesterol in the blood have no relation with the urine results. HDL is borderline low and LDL is slightly high, depending on the reference ranges of the lab you used. Also you did not mention how high the total cholesterol is, and if there is family history of heart disease. Trace albumin in the urine is commonly seen, not significantmay need repeat if your doctor is concerned.
MADREN HEALTHCARE LLP - Exporter, Manufacturer & Supplier of Protein Supplement 200g Soya Ren Powder,200g Whey Mad Protein,Egg White Albumin Protein Powder,1 Kg Weight Gainer, India
Comparison of the supercooling preservation of rat hepatocytes with other preservation modalities in long term plate culture.Albumin secretion of cells preserve
Theres no detailed assessment of that. The investigators can argue that they have more context to interpret what perhaps will be ambiguous imaging findings. On the other hand, they (we) may also be more biased to interpret results as favorable because they want their patients to be doing well; they may also allow their clinical perception of how a patient is doing to affect their judgment of the findings on the scans. Its not completely clear whos more right or wrong, but we generally rely on the professional radiologists who comprise the independent reviewing committee as being more objective.. The company suggested that additional efficacy data would be available later this year. Ill admit that it makes me skeptical when a company has response rate data in March but doesnt have progression-free survival data, at least. There isnt that long of a lag between the first few scans and a detection of progression in many patients (unfortunately). Since we generally see that companies will shout ...
Serum albumin purification[edit]. Of many uses of affinity chromatography, one use of it is seen in affinity purification of ... In affinity purification of serum albumin, the stationary used for collecting or attracting serum proteins can be Cibacron Blue ... This type of purification is helpful in removing excess albumin and α2-macroglobulin contamination, when performing mass ... Naval, Javier; Calvo, Miguel; Lampreave, Fermin; Piñeiro, Andrés (1983-01-01). "Affinity chromatography of serum albumin: An ...
Albumin[edit]. Albumin is the major fraction in a normal SPEP. A fall of 30% is necessary before the decrease shows on ... Absence of albumin, known as analbuminaemia, is rare. A decreased level of albumin, however, is common in many diseases, ... Increased AMG is also noted in rats with no albumin indicating that this is a response to low albumin rather than nephrotic ... Albumin - alpha-1 interzone[edit]. Even staining in this zone is due to alpha-1 lipoprotein (high density lipoprotein - HDL). ...
Albumin historia[muokkaa , muokkaa wikitekstiä]. Nauhoittaminen ja julkaisu[muokkaa , muokkaa wikitekstiä]. Rumpali Steven ... Vaihtoehtoisesti hän esitti kahden tupla-albumin - tässä tapauksessa siis Use Your Illusion I:n ja Use Your Illusion II:n - ... Albumin on tuottanut Mike Clink, ja se julkaistiin 17. syyskuuta vuonna 1991 samanaikaisesti yhtyeen neljännen studioalbumin, ... Albumin avausraita "Right Next Door to Hell" kertoo Rosen mukaan hänen jatkuvasta vihasuhteestaan pakkomielteiseen naapuriinsa. ...
Albumin single[muokkaa , muokkaa wikitekstiä]. Vuosi Kappale Billboard Hot 100 Hot R&B/Hip-Hop Singles & Tracks ... Albumin kaikki kappaleet ovat ennen julkaisemattomia. Still I Risen julkaisi 14. joulukuuta 1999 Interscope Records, Death Row ... ". "Baby Don't Cry (Keep Ya Head Up II)" on myös albumin ainoa kappale, josta kuvattiin musiikkivideo. ...
Albumin tuotti Martin Birch, ja levy-yhtiö EMI julkaisi albumin Euroopassa 11. huhtikuuta 1988. Yhdysvalloissa albumin julkaisi ... Albumin kahdeksasta kappaleesta kolmea säveltänyt Adrian Smith erosi yhtyeestä albumin kiertueen jälkeen. ... Albumin teema, sanoitukset ja synty[muokkaa , muokkaa wikitekstiä]. »Se oli meidän seitsemäs studiolevy, eikä mulla ollut sille ... Albumin kappaleista "Can I Play with Madness" (Britannian singlelistan 3.), "The Evil That Men Do" (brittilistan 5.) ja "The ...
Albumin konsepti[muokkaa , muokkaa wikitekstiä]. Albumin peruskonsepti on erittäin tummanpuhuva. Sanoitukset käsittelevät ... Albumin myötä yhtye nousi suureen suosioon ja siitä tuli yksi grunge-musiikin johtavista kokoonpanoista. Albumi käsittelee ... Monet albumin sanoituksista, eritoten kappaleet "God Smack", "Angry Chair" ja "Junkhead", puivat laulaja Layne Staleyn ... Albumin viimeinen kappale "Would?" on Cantrellin kunnianosoitus vuonna 1990 kuolleelle Andrew Woodille. ...
tammikuuta 2012.[14] Albumin nimi, MDNA on näennäinen lyhenne Madonnan nimestä.[15][16] Albumin nimestä nousi pian nimen ... Kansikuva ja albumin nimeäminen[muokkaa , muokkaa wikitekstiä]. Madonna julkisti uuden albuminsa nimen The Graham Norton ... Albumin avaussingle Give Me All Your Luvin' vuosi internetiin 8. marraskuuta nimellä "Give Me All Your Love".[5] 15. joulukuuta ... Albumin ensimmäinen single, "Give Me All Your Luvin'", julkaistiin helmikuun 3. päivä digitaalisesti.[3] Singlen demo vuosi ...
Kyseisessä julkaisussa albumin nimi on kuitenkin Alive IV: The Millenium Concert. Kappalelista[edit , edit source]. Levy 1[edit ... sillä albumin julkaisusta tiedotettiin jo vuonna 1999[2]. Albumin kansitaide ehdittiin jo paljastaa, ja levylle konsertissa ... Albumin taustaa[edit , edit source]. Kissin alkuperäisen eli Gene Simmonsin, Paul Stanleyn, Peter Crissin ja Ace Frehleyn ... Albumin tuotti Mark Opitz[1], ja se on yhtyeen Alive-livealbumisarjan neljäs osa. ...
... albumin, transferrin and transthyretin: a practical, simple and clinically relevant approach in a large cohort". Journal of ... "Transcriptional regulation of transferrin and albumin genes by retinoic acid in human hepatoma cell line Hep3B". The ...
Serum albumin. *Human serum albumin. *Bovine serum albumin. *Prealbumin. Other. *C-reactive protein ...
... is known to be plasma protein bound to albumin, SHBG, and CBG.[4][5][6] ...
... , also known as "whey protein", is the albumin contained in milk and obtained from whey. Lactalbumin is found in the ... Serum proteins, including albumin, remained unchanged and within normal range, indicating that protein replenishment per se was ... The presence in the serum albumin fraction of glutamylcysteine groups (rare in food protein) and the specific intramolecular ... Whey protein concentrate was prepared so that the most thermosensitive proteins, such as serum albumin which contains 6 ...
albumin. *α1-acid glycoprotein. *lipoproteins. Some drug interactions with warfarin are due to changes in protein binding.[16] ...
In medicine, it is known as the primary carrier of basic (positively charged) drugs (whereas albumin carries acidic (negatively ... Aging causes a small decrease in plasma albumin levels; if anything, there is a small increase in alpha-1-acid glycoprotein. ... the other three are albumin, very low-density lipoprotein particle size, and citrate).[7] ...
Albumin- oids Crude Fiber Extractive Matter Free From Nitrogen Fat Meadow hay- poor 14.3 5.0 7.5 33.5 38.2 1.5 ...
Albumin , 4.0 g/dl. *White blood count ≥ 15,000/µl. Other studies have reported the following to be the most important adverse ...
... is highly plasma protein bound, 99% bound to albumin. Albumin is a the most abundant protein found in human plasma ... "plasma albumin". TheFreeDictionary.com. Saunders. Retrieved 7 January 2018. Vries, Helga E. de; Kuiper, Johan; Boer, Albertus G ...
... , or trenbolone cyclohexylmethylcarbonate, sold under the brand names Parabolan and Hexabolan, is a synthetic, injected anabolic-androgenic steroid (AAS) of the nandrolone group and an androgen ester - specifically, the C17β hexahydrobenzylcarbonate (cyclohexylmethylcarbonate) ester of trenbolone - which was marketed in France for medical use in humans but has since been discontinued.[1] It was introduced in France in 1980 and was voluntarily discontinued by its manufacturer in 1997.[1][2] The drug acts as a long-lasting prodrug of trenbolone when administered via intramuscular injection.[1] It was used clinically at a dosage of one ampoule (76 mg, corresponding to 50 mg trenbolone base) every 10 days.[1] ...
Androstenedione immunogens: Androvax (androstenedione albumin). *Ovandrotone albumin (Fecundin). *#WHO-EM. *‡Withdrawn from ...
InChI=1S/C29H31NO4/c1-20-26-14-11-24(32)19-27(26)34-29(28(20)21-5-9-23(31)10-6-21)22-7-12-25(13-8-22)33-18-17-30-15-3-2-4-16-30/h5-14,19,29,31-32H,2-4,15-18H2,1H3/t29-/m0/ ...
The Women's Health Initiative trials were conducted between 1991 and 2006 and were the first large, double-blind, placebo-controlled clinical trials of HRT in healthy women.[52] Their results were both positive and negative, suggesting that during the time of hormone therapy itself, there are increases in invasive breast cancer, stroke and lung clots. Other risks include increased endometrial cancer, gallbladder disease, and urinary incontinence, while benefits include decreased hip fractures, decreased incidence of diabetes, and improvement of vasomotor symptoms. There also is an increased risk of dementia with HRT in women over 65, though when given earlier it appears to be neuroprotective. After the cessation of HRT, the WHI continued observe its participants, and found that most of these risks and benefits dissipated, though some elevation in breast cancer risk did persist.[24] Other studies have also suggested an increased risk of ovarian cancer.[43] The arm of the WHI receiving combined ...
The plasma protein binding of norethisterone is 97%.[4] It is bound 61% bound to albumin and 36% bound to SHBG.[4] ...
CDMT was the key steroid administered to approximately 10,000 athletes from East Germany (GDR) as secret official policy, often without their knowing the nature of the "vitamins" they were forced to take. The doping program was run by the East German Government from about 1968 until 1989 when the Berlin Wall was destroyed. The doping program was known as State Plan Topic 14.25. The doping was done in secret; it was only in the 1990s that Franke and Berendonk looked closely at the original archived information and discovered the true scope of just how well-planned and successful the doping regime had been (in terms of medal success and world record performances).[2] After the collapse of the East German regime, people responsible for the forced doping were found guilty of causing grievous bodily harm to about 10,000 sportspeople; victims were compensated. In later life former athletes developed serious health problems believed due to the drugs; psychotic episodes were attributed to CDMT.[3] ...
... (INN) (brand names Colpotrofin, Colpotrophine, Delipoderm), also known as estradiol 3-propyl 17β-methyl diether, is a synthetic steroidal estrogen which is used topically in a 1% cream formulation.[1][2][3][4] It is the 3-propyl and 17β-methyl diether of estradiol.[5] The drug is described as a tropic agent and antiseborrheic.[1] It has not been found to be effective in the treatment of androgenic alopecia or other conditions of cutaneous androgenization.[6][7] ...
... (INN, JAN) (brand names Steranabol Depo, Steranabol Ritardo; former developmental code name FI-5852), or oxabolone cypionate, also known as 4-hydroxy-19-nortestosterone 17β-cypionate or estr-4-en-4,17β-diol-3-one 17β-cypionate, is synthetic and injected anabolic-androgenic steroid (AAS) and derivative of nandrolone (19-nortestosterone) which has been marketed in Europe.[1][2][3] It is the C17β cypionate ester and a prodrug of oxabolone (4-hydroxy-19-nortestosterone).[2][3] ...
... batches of bromocresol green were used in a study of several modifications of the bromocresol green method for serum albumin. ...
The albumin level that was 3. He was treated by intravenous albumin and intermittent parenteral nutritional support. Lipid and ...
Serum albumin[edit]. Main article: Serum albumin. Serum albumin is the most abundant blood plasma protein and is produced in ... For the specific albumins found in vertebrate bloodstreams, see serum albumin. For other uses, see Albumin (disambiguation). ... Serum albumin levels[edit]. The normal range of human serum albumin in adults (, 3 y.o.) is 3.5 to 5 g/dL. For children less ... Wikisource has the text of the 1911 Encyclopædia Britannica article Albumin.. *Albumins at the US National Library of Medicine ...
ALBUMIN_1 (PS00212). Accession PS00212 Integration. Serum albumin, conserved site (IPR020857) Member database. PROSITE patterns ...
Albumin definition, any of a class of simple, sulfur-containing, water-soluble proteins that coagulate when heated, occurring ... albumin. in Science. albumin. [ăl-byōō′mĭn]. *A class of proteins found in egg white, milk, blood, and various other plant and ... albumin. in Medicine. albumin. (ăl-byōō′mĭn). n.. *A class of simple, water-soluble proteins that can be coagulated by heat and ... albumin. albumen. noun. *any of a group of simple water-soluble proteins that are coagulated by heat and are found in blood ...
InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites. We combine protein signatures from a number of member databases into a single searchable resource, capitalising on their individual strengths to produce a powerful integrated database and diagnostic tool.
I had a test done showing my albumin levels are a little low than normal. Can this be dangerous?? If so in what ... ... Albumin gopo92 Hello. I am 18 years ood and have been suffering from intestinal disease since 10 years. I had a test done ... Albumin is a protein produced by the liver and it forms an important part of the blood as it helps keep the water in the blood ... If your albumin were very low you then you would be increasingly worried that this value was representative of one of the ...
Is there a home test for albumin levels?. Not for blood albumin; you can test for high albumin levels in urine with a dipstick ... Albumin may also be ordered to evaluate a persons nutritional status.. When is it ordered?. An albumin test is frequently ... The urine albumin test (in the past, called a microalbumin test) detects and measures albumin in the urine as an early ... A low albumin level may be an indication that further investigation may be warranted. A low albumin may reflect a temporary ...
... with albumin) Injection: learn about side effects, dosage, special precautions, and more on MedlinePlus ... with albumin) injection. If you are female, you should use birth control during your treatment with paclitaxel (with albumin) ... Paclitaxel (with albumin) may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away: *pain ... Paclitaxel (with albumin) injection may cause a large decrease in the number of white blood cells (a type of blood cell that is ...
A serum albumin test measures the amount of this protein in the clear liquid portion of the blood. ... Albumin is a protein made by the liver. ... Albumin is a protein made by the liver. A serum albumin test ... Decreased blood albumin may occur when your body does not get or absorb enough nutrients, such as with:. *After weight-loss ... Albumin - serum, urine, and 24-hour urine. In: Chernecky CC, Berger BJ, eds. Laboratory Tests and Diagnostic Procedures. 6th ed ...
The role of albumin receptors in regulation of albumin homeostasis: Implications for drug delivery ... Interdomain zinc site on human albumin. Alan J. Stewart, Claudia A. Blindauer, Stephen Berezenko, Darrell Sleep, Peter J. ... Interdomain zinc site on human albumin. Alan J. Stewart, Claudia A. Blindauer, Stephen Berezenko, Darrell Sleep, Peter J. ... Interdomain zinc site on human albumin. Alan J. Stewart, Claudia A. Blindauer, Stephen Berezenko, Darrell Sleep, and Peter J. ...
A list of US medications equivalent to Human Albumin Demo is available on the Drugs.com website. ... Human Albumin Demo is a medicine available in a number of countries worldwide. ... Ingredient matches for Human Albumin Demo. Albumin Human. Albumin Human is reported as an ingredient of Human Albumin Demo in ... Human Albumin Demo. Human Albumin Demo may be available in the countries listed below. ...
ALBUMIN PHENOTYPES IN TURKEYS. Indalecio R. Quinteros, R. W. C. Stevens, C. Stormont and V. S. Asmundson ... ALBUMIN PHENOTYPES IN TURKEYS. Indalecio R. Quinteros, R. W. C. Stevens, C. Stormont and V. S. Asmundson ... ALBUMIN PHENOTYPES IN TURKEYS. Indalecio R. Quinteros, R. W. C. Stevens, C. Stormont and V. S. Asmundson ...
Albumin Antibody in Routine Rhesus Grouping Br Med J 1951; 1 :1490 ... Albumin Antibody in Routine Rhesus Grouping. Br Med J 1951; 1 doi: https://doi.org/10.1136/bmj.1.4721.1490 (Published 30 June ...
BR/>
View more information on albumin>human serum albumin. ... Sigma-Aldrich has partnered with the technology holders of recombinant human albumin products expressed in Rice, Pichia Product Directory > Biochemicals and Reagents > Proteins and Derivatives > Albumin > Recombinant/Transgenic Human ... Albumin human recombinant, expressed in Pichia pastoris, 5% in aqueous buffer, ≥90% (SDS-PAGE) * pricing ...
... Joachim Steiner steiner at biomed.uni-erlangen.de Thu Jan 29 03:49:16 EST 1998 *Previous message: ... Could anybody tell me please what happens to serum albumin on platinum Surfaces. More precisely : How can the unusual ... adsorption behaviour of serum albumin on platinum, measured by means of ellipsometry, be explained. The time dependence of the ...
This medicine works by increasing plasma volume or levels of albumin in the blood. Albumin is used to replace blood volume loss ... Medicinal albumin is made of plasma proteins from human blood. ... Albumin is a protein produced by the liver that circulates in ... What is albumin?. Albumin is a protein produced by the liver that circulates in plasma (the clear liquid portion of your blood ... How is albumin given?. Albumin is injected into a vein through an IV. A healthcare provider will give you this injection. ...
Make research projects and school reports about albumin easy with credible articles from our FREE, online encyclopedia and ... Principal forms are egg albumin (egg white), milk albumin and blood albumin. In a healthy human, it constitutes about 5% of the ... albumin (ălbyōō´mən) [Lat.,=white of egg], member of a class of water-soluble, heat-coagulating proteins. Albumins are widely ... Albumins occur in egg white (the protein component of which is known as albumen), blood, milk, and plants. Serum albumins, ...
Rate your experience with Albumin-Saline injection on - WebMD including the side effects, drug interactions, effectiveness, ...
Human serum albumin (HSA) is the intravenous protein most commonly used in the world for therapeutic ends. It is employed to ... Human serum albumin (HSA) is the intravenous protein most commonly used in the world for therapeutic ends. It is employed to ... Commercial albumin is currently extracted from blood, but the lack of sufficient reserves to cover all worldwide needs has ... While the price at the pharmacy of albumin produced using plasma is 4 euros per gram, that obtained from yeasts or mammal cells ...
Treatments and Tools for albumin. Find albumin information, treatments for albumin and albumin symptoms. ... albumin - MedHelps albumin Center for Information, Symptoms, Resources, ... Hi, My most recent tests came back with high lymphocytes (4.46X10) and high albumin (28.8 ... ... My 15 year olds results: albumin 4.71 globulin 2.23 a/g ratio 2.11 bilirubin total... ...
Ovandrotone albumin (INN, BAN) (brand names Fecundin, Ovastim), also known as polyandroalbumin, as well as ovandrotone:human ... Indeed, ovandrotone albumin has been found to significantly increase luteinizing hormone levels throughout the estrous cycle in ... It is a conjugate of ovandrotone (androstenedione-7α-carboxyethylthioether) and human serum albumin. The drug was developed by ... Ovandrotone albumin produces transient immunity against androstenedione, and the generation of antibodies against ...
Using the results of quantitative CSF and serum albumin assays, a CSF (in mg/dL)/serum (in g/dL) albumin index can be ... Albumin is a particularly suitable indicator of protein because it is neither synthesized nor metabolized intrathecally. In CSF ... The degree of permeability of the blood-brain barrier can be evaluated by the quantitative measurements of albumin in the CSF ... Albumin, Cerebrospinal Fluid. 1746-7. 012230. Albumin, CSF. mg/dL. 1746-7. ...
Albumin is the most prevalent protein in your blood, and without it, you can experience a number of symptoms. ... The role of albumin in fluid balance and transport means low albumin levels can cause bodily problems that manifest in symptoms ... The albumin in your blood moves the mineral calcium, the hormone progesterone and medicines throughout your tissues. Albumin ... To maintain normal blood albumin ranges, you should have between 3.4 and 5.4 g/dL of albumin in your blood. ...
ALBUMIN HUMAN (UNII: ZIF514RVZR) (ALBUMIN HUMAN - UNII:ZIF514RVZR) ALBUMIN HUMAN. 12.5 g in 50 mL. ... Albumin (Human) 25% Solution AlbuRx® 25 Contains: 12.5 g Albumin (Human) in 50 mL of buffered diluent. Stabilized with 0.02 M ... One vial containing 12.5 grams of albumin. [NDC 44206-251-90]. 100 mL. 44206-251-10. One vial containing 25 grams of albumin. [ ... In all these settings, the circulating albumin mass is initially maintained by a gradual transfer of extravascular albumin to ...
  • Sigma-Aldrich has partnered with the technology holders of recombinant human albumin products expressed in Rice, Pichia , and Saccharomyces to manufacture and distribute both research grade as well as custom bulk manufacturing grades. (sigmaaldrich.com)
  • EKF Diagnostics, the global in vitro diagnostics company, announces the availability of a liquid, enzymatic test for glycated albumin (GA) that was recently FDA cleared for sales in the U.S. GA, used for intermediate term monitoring of glycemic control in diabetes patients, will be showcased at the 2019 AACC Clinical Lab Expo (August 6-8th in Anaheim, CA, Booth #2952). (news-medical.net)
  • In vitro covalent modification of serum albumin by acrolein. (cdc.gov)
  • Albumin in vitro SimpleStep ELISA ® (Enzyme-Linked Immunosorbent Assay) kit is designed for the quantitative measurement of Albumin levels in human plasma, serum, and urine. (abcam.com)
  • In the unadjusted samples, albumin was degraded in 11 out of 40 samples stored at -20 degrees C. In the in vitro experiments, both endogenous albumin and exogenous albumin added to urine were rapidly degraded into large fragments within minutes after adjustment to low pH. (nih.gov)
  • We hypothesize that the orientation of albumin at the air/liquid interface plays an important role in vapor TDI conjugation and, thus, could influence biological responses to exposure and the development of in vitro assays for exposure and immune sensitivity. (cdc.gov)
  • 96%, white lyophilized powder Synonyms: BSA, Bovine albumin Albumins are a group of acidic proteins which occur plentifully in the body fluids and tissues of mammals and in some plant seeds. (thomassci.com)
  • Another option worked on over recent years has been the production of albumin from vegetables, always using nuclear transformation. (scienceblog.com)
  • A property highly valued by the experts has to be added to these positive results: the production of albumin from plants using this technique does not involve the escape of genes through pollen transmission given that, with most crops under cultivation, the genome of the plastids is inherited maternally. (scienceblog.com)
  • The colloid osmotic or oncotic properties of albumin at this moment constitute the predominant reason for its clinical use. (nih.gov)
  • The results indicated that although lysine and histidine residues were modified, such modification did not alter the functions or biological properties of albumin, such as binding to palmitic-acid or bromcresol-green. (cdc.gov)
  • Agricultural engineer, Alicia Fernández San Millán, has developed a novel technique in Spain - plastidial transformation, in order to produce, in a recombinant form, human albumin from tobacco plants. (scienceblog.com)
  • Since the oncotic pressure of AlbuRx ® 25, Albumin (Human) 25% solution is about four times higher than that of normal human serum, it will expand the plasma volume if interstitial water is available for an inflow through the capillary walls. (nih.gov)
  • In the absence of hyperhydration, the treatment of an acute volume deficit with AlbuRx ® 25 should therefore include isotonic electrolyte solutions with an albumin:electrolyte ratio of 1:3 or 1:4. (nih.gov)
  • Albumin is essential for maintaining the osmotic pressure needed for proper distribution of body fluids between intravascular compartments and body tissues. (bionity.com)
  • All the proteins of the albumin family are water- soluble , moderately soluble in concentrated salt solutions, and experience heat denaturation . (wikipedia.org)
  • A primed-constant infusion of a stable isotopic tracer of phenylalanine was used to determine hepatic fractional synthetic rate (FSR) and absolute synthetic rate (ASR) of albumin from the enrichment of phenylalanine in albumin. (nih.gov)
  • Albumin infusion in patients undergoing large-volume paracentesis: a meta-analysis of randomized trials. (medicin.dk)
  • Abstract We will evaluate four photoactivatable fatty acid analogs and three photoactivatable C16 alkylchain derivatives for their ability to derivatize to four representative biomaterials and subsequently adsorbhuman albumin. (sbir.gov)
  • Albumin plays a major role in maintaining fluid balance in your body. (livestrong.com)
  • If you do lose albumin in your body, the fluid can leak into your tissues and cause swelling. (livestrong.com)
  • In addition to its role in maintaining fluid balance, albumin also acts as a transport vessel. (livestrong.com)
  • Increased albumin content and reduced free water clearance contribute to a retention of fluid within the circulation after intense exercise. (nih.gov)
  • A remarkable change occurs when many albumins are boiled with water, or treated with certain acids, their solubility and general characters being entirely altered, and the fluid becoming coagulated. (wikisource.org)
  • Human albumin is the only colloid solution of biologic origin with a molecular weight of 60 kDa. (clinicaltrials.gov)
  • Although crystalloid solutions and colloid-containing plasma substitutes can be used in emergency treatment of shock , Albumin (Human) has a longer intravascular half-life than crystalloid solutions. (rxlist.com)
  • First, the significant expense and theoretic risks of albumin and other colloid solutions dictate that it is incumbent on the users and manufacturers of colloid products to demonstrate superiority to crystalloid. (annals.org)
  • In lab experiments it has been shown that all-trans retinoic acid down regulates human albumin production Other albumin types include the storage protein ovalbumin in egg white, and different storage albumins in the seeds of some plants, including hemp. (wikipedia.org)