Vitamin D-Binding Protein: An alpha-globulin found in the plasma of man and other vertebrates. It is apparently synthesized in the liver and carries vitamin D and its metabolites through the circulation and mediates the response of tissue. It is also known as group-specific component (Gc). Gc subtypes are used to determine specific phenotypes and gene frequencies. These data are employed in the classification of population groups, paternity investigations, and in forensic medicine.Serum Albumin: A major protein in the BLOOD. It is important in maintaining the colloidal osmotic pressure and transporting large organic molecules.Albumins: Water-soluble proteins found in egg whites, blood, lymph, and other tissues and fluids. They coagulate upon heating.Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)Blood Proteins: Proteins that are present in blood serum, including SERUM ALBUMIN; BLOOD COAGULATION FACTORS; and many other types of proteins.Egg White: The white of an egg, especially a chicken's egg, used in cooking. It contains albumin. (Random House Unabridged Dictionary, 2d ed)Serum Albumin, Bovine: Serum albumin from cows, commonly used in in vitro biological studies. (From Stedman, 25th ed)alpha-Fetoproteins: The first alpha-globulins to appear in mammalian sera during FETAL DEVELOPMENT and the dominant serum proteins in early embryonic life.Barbiturates: A class of chemicals derived from barbituric acid or thiobarbituric acid. Many of these are GABA MODULATORS used as HYPNOTICS AND SEDATIVES, as ANESTHETICS, or as ANTICONVULSANTS.Complement C5a, des-Arginine: A derivative of complement C5a, generated when the carboxy-terminal ARGININE is removed by CARBOXYPEPTIDASE B present in normal human serum. C5a des-Arg shows complete loss of spasmogenic activity though it retains some chemotactic ability (CHEMOATTRACTANTS).Protein-Losing Enteropathies: Pathological conditions in the INTESTINES that are characterized by the gastrointestinal loss of serum proteins, including SERUM ALBUMIN; IMMUNOGLOBULINS; and at times LYMPHOCYTES. Severe condition can result in HYPOGAMMAGLOBULINEMIA or LYMPHOPENIA. Protein-losing enteropathies are associated with a number of diseases including INTESTINAL LYMPHANGIECTASIS; WHIPPLE'S DISEASE; and NEOPLASMS of the SMALL INTESTINE.Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)Serum Albumin: A major protein in the BLOOD. It is important in maintaining the colloidal osmotic pressure and transporting large organic molecules.Albumins: Water-soluble proteins found in egg whites, blood, lymph, and other tissues and fluids. They coagulate upon heating.Hypoalbuminemia: A condition in which albumin level in blood (SERUM ALBUMIN) is below the normal range. Hypoalbuminemia may be due to decreased hepatic albumin synthesis, increased albumin catabolism, altered albumin distribution, or albumin loss through the urine (ALBUMINURIA).Lymphangiectasis, Intestinal: Dilatation of the intestinal lymphatic system usually caused by an obstruction in the intestinal wall. It may be congenital or acquired and is characterized by DIARRHEA; HYPOPROTEINEMIA; peripheral and/or abdominal EDEMA; and PROTEIN-LOSING ENTEROPATHIES.Acne Vulgaris: A chronic disorder of the pilosebaceous apparatus associated with an increase in sebum secretion. It is characterized by open comedones (blackheads), closed comedones (whiteheads), and pustular nodules. The cause is unknown, but heredity and age are predisposing factors.Isotretinoin: A topical dermatologic agent that is used in the treatment of ACNE VULGARIS and several other skin diseases. The drug has teratogenic and other adverse effects.Tretinoin: An important regulator of GENE EXPRESSION during growth and development, and in NEOPLASMS. Tretinoin, also known as retinoic acid and derived from maternal VITAMIN A, is essential for normal GROWTH; and EMBRYONIC DEVELOPMENT. An excess of tretinoin can be teratogenic. It is used in the treatment of PSORIASIS; ACNE VULGARIS; and several other SKIN DISEASES. It has also been approved for use in promyelocytic leukemia (LEUKEMIA, PROMYELOCYTIC, ACUTE).Nephrotic Syndrome: A condition characterized by severe PROTEINURIA, greater than 3.5 g/day in an average adult. The substantial loss of protein in the urine results in complications such as HYPOPROTEINEMIA; generalized EDEMA; HYPERTENSION; and HYPERLIPIDEMIAS. Diseases associated with nephrotic syndrome generally cause chronic kidney dysfunction.Serum Albumin: A major protein in the BLOOD. It is important in maintaining the colloidal osmotic pressure and transporting large organic molecules.Albumins: Water-soluble proteins found in egg whites, blood, lymph, and other tissues and fluids. They coagulate upon heating.Pichia: Yeast-like ascomycetous fungi of the family Saccharomycetaceae, order SACCHAROMYCETALES isolated from exuded tree sap.Serum Albumin, Bovine: Serum albumin from cows, commonly used in in vitro biological studies. (From Stedman, 25th ed)Serum Albumin, Radio-Iodinated: Normal human serum albumin mildly iodinated with radioactive iodine (131-I) which has a half-life of 8 days, and emits beta and gamma rays. It is used as a diagnostic aid in blood volume determination. (from Merck Index, 11th ed)Powders: Substances made up of an aggregation of small particles, as that obtained by grinding or trituration of a solid drug. In pharmacy it is a form in which substances are administered. (From Dorland, 28th ed)Recombinant Proteins: Proteins prepared by recombinant DNA technology.Saccharomyces cerevisiae: A species of the genus SACCHAROMYCES, family Saccharomycetaceae, order Saccharomycetales, known as "baker's" or "brewer's" yeast. The dried form is used as a dietary supplement.Technetium Tc 99m Aggregated Albumin: A gamma-emitting radionuclide imaging agent used for the diagnosis of diseases in many tissues, particularly in cardiovascular and cerebral circulation.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Genetics: The branch of science concerned with the means and consequences of transmission and generation of the components of biological inheritance. (Stedman, 26th ed)Turkeys: Large woodland game BIRDS in the subfamily Meleagridinae, family Phasianidae, order GALLIFORMES. Formerly they were considered a distinct family, Melegrididae.TurkeyAlbumins: Water-soluble proteins found in egg whites, blood, lymph, and other tissues and fluids. They coagulate upon heating.Serum Albumin: A major protein in the BLOOD. It is important in maintaining the colloidal osmotic pressure and transporting large organic molecules.Phenotype: The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.Genetics, Population: The discipline studying genetic composition of populations and effects of factors such as GENETIC SELECTION, population size, MUTATION, migration, and GENETIC DRIFT on the frequencies of various GENOTYPES and PHENOTYPES using a variety of GENETIC TECHNIQUES.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Mutation: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.Serum Albumin, Bovine: Serum albumin from cows, commonly used in in vitro biological studies. (From Stedman, 25th ed)Serum Albumin, Bovine: Serum albumin from cows, commonly used in in vitro biological studies. (From Stedman, 25th ed)Serum Albumin: A major protein in the BLOOD. It is important in maintaining the colloidal osmotic pressure and transporting large organic molecules.Platinum: Platinum. A heavy, soft, whitish metal, resembling tin, atomic number 78, atomic weight 195.09, symbol Pt. (From Dorland, 28th ed) It is used in manufacturing equipment for laboratory and industrial use. It occurs as a black powder (platinum black) and as a spongy substance (spongy platinum) and may have been known in Pliny's time as "alutiae".Albumins: Water-soluble proteins found in egg whites, blood, lymph, and other tissues and fluids. They coagulate upon heating.Adsorption: The adhesion of gases, liquids, or dissolved solids onto a surface. It includes adsorptive phenomena of bacteria and viruses onto surfaces as well. ABSORPTION into the substance may follow but not necessarily.Actinoid Series Elements: A series of radioactive elements from ACTINIUM, atomic number 89, to and including LAWRENCIUM, atomic number 103.Platinum Compounds: Inorganic compounds which contain platinum as the central atom.Proprotein Convertase 2: A serine endopeptidase that has specificity for cleavage at ARGININE. It cleaves a variety of prohormones including PRO-OPIOMELANOCORTIN, proluteinizing-hormone-releasing hormone, proenkephalins, prodynorphin, and PROINSULIN.Surface Properties: Characteristics or attributes of the outer boundaries of objects, including molecules.Cattle: Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.Serum Albumin: A major protein in the BLOOD. It is important in maintaining the colloidal osmotic pressure and transporting large organic molecules.Albumins: Water-soluble proteins found in egg whites, blood, lymph, and other tissues and fluids. They coagulate upon heating.Blood-Brain Barrier: Specialized non-fenestrated tightly-joined ENDOTHELIAL CELLS with TIGHT JUNCTIONS that form a transport barrier for certain substances between the cerebral capillaries and the BRAIN tissue.Serum Albumin, Bovine: Serum albumin from cows, commonly used in in vitro biological studies. (From Stedman, 25th ed)Specimen Handling: Procedures for collecting, preserving, and transporting of specimens sufficiently stable to provide accurate and precise results suitable for clinical interpretation.Cerebrospinal Fluid: A watery fluid that is continuously produced in the CHOROID PLEXUS and circulates around the surface of the BRAIN; SPINAL CORD; and in the CEREBRAL VENTRICLES.Blood: The body fluid that circulates in the vascular system (BLOOD VESSELS). Whole blood includes PLASMA and BLOOD CELLS.Tooth, Unerupted: A normal developing tooth which has not yet perforated the oral mucosa or one that fails to erupt in the normal sequence or time interval expected for the type of tooth in a given gender, age, or population group.Equipment Contamination: The presence of an infectious agent on instruments, prostheses, or other inanimate articles.Permeability: Property of membranes and other structures to permit passage of light, heat, gases, liquids, metabolites, and mineral ions.Albumins: Water-soluble proteins found in egg whites, blood, lymph, and other tissues and fluids. They coagulate upon heating.Pharmacists: Those persons legally qualified by education and training to engage in the practice of pharmacy.Serum Albumin: A major protein in the BLOOD. It is important in maintaining the colloidal osmotic pressure and transporting large organic molecules.Serum Albumin, Bovine: Serum albumin from cows, commonly used in in vitro biological studies. (From Stedman, 25th ed)Community Pharmacy Services: Total pharmaceutical services provided to the public through community pharmacies.Professional Role: The expected function of a member of a particular profession.Education, Pharmacy, Continuing: Educational programs designed to inform graduate pharmacists of recent advances in their particular field.Pharmaceutical Services: Total pharmaceutical services provided by qualified PHARMACISTS. In addition to the preparation and distribution of medical products, they may include consultative services provided to agencies and institutions which do not have a qualified pharmacist.Serum Albumin, Radio-Iodinated: Normal human serum albumin mildly iodinated with radioactive iodine (131-I) which has a half-life of 8 days, and emits beta and gamma rays. It is used as a diagnostic aid in blood volume determination. (from Merck Index, 11th ed)Pharmacy Service, Hospital: Hospital department responsible for the receiving, storing, and distribution of pharmaceutical supplies.Albumins: Water-soluble proteins found in egg whites, blood, lymph, and other tissues and fluids. They coagulate upon heating.Serum Albumin: A major protein in the BLOOD. It is important in maintaining the colloidal osmotic pressure and transporting large organic molecules.Serum Albumin, Bovine: Serum albumin from cows, commonly used in in vitro biological studies. (From Stedman, 25th ed)Serum Albumin, Radio-Iodinated: Normal human serum albumin mildly iodinated with radioactive iodine (131-I) which has a half-life of 8 days, and emits beta and gamma rays. It is used as a diagnostic aid in blood volume determination. (from Merck Index, 11th ed)Receptors, Albumin: Cell surface proteins that bind albumin with high affinity and trigger intracellular changes influencing the behavior of cells.Technetium Tc 99m Aggregated Albumin: A gamma-emitting radionuclide imaging agent used for the diagnosis of diseases in many tissues, particularly in cardiovascular and cerebral circulation.Albuminuria: The presence of albumin in the urine, an indicator of KIDNEY DISEASES.Health Resources: Available manpower, facilities, revenue, equipment, and supplies to produce requisite health care and services.Hypoalbuminemia: A condition in which albumin level in blood (SERUM ALBUMIN) is below the normal range. Hypoalbuminemia may be due to decreased hepatic albumin synthesis, increased albumin catabolism, altered albumin distribution, or albumin loss through the urine (ALBUMINURIA).2S Albumins, Plant: A major class of water-soluble seed storage proteins. Many proteins from this class are major PLANT ALLERGENS.

Isolation of rat liver albumin messenger RNA. (1/2483)

Rat liver albumin messenger RNA has been purified to apparent homogeneity by means of polysome immunoprecipitation and poly(U)-Sepharose affinity chromatography. Specific polysomes synthesizing albumin were separated from total liver polysomes through a double antibody technique which allowed isolation of a specific immunoprecipitate. The albumin-polysome immunoprecipitate was dissolved in detergent and the polysomal RNA was separated from protein by sucrose gradient centrifugation. Albumin mRNA was then separated from ribosomal RNA by affinity chromatography through the binding of poly(U)-Sepharose to the polyadenylate 3' terminus of the mRNA. Pure albumin mRNA migrated as an 18 S peak on 85% formamide-containing linear sucrose gradients and as a 22 S peak on 2.5% polyacrylamide gels in sodium dodecyl sulfate. It coded for the translation of authentic liver albumin when added to a heterologous protein-synthesizing cell-free system derived from either rabbit reticulocyte lysates or wheat germ extracts. Translation analysis in reticulocyte lysates indicated that albumin polysomes were purified approximately 9-fold from total liver polysomes, and that albumin mRNA was purified approximately 74-fold from albumin polysomal RNA. The total translation product in the mRNA-dependent wheat germ system, upon addition of the pure mRNA, was identified as authentic albumin by means of gel electrophoresis and tryptic peptide chromatography.  (+info)

Sentinel lymph node biopsy and axillary dissection in breast cancer: results in a large series. (2/2483)

BACKGROUND: Axillary lymph node dissection is an established component of the surgical treatment of breast cancer, and is an important procedure in cancer staging; however, it is associated with unpleasant side effects. We have investigated a radioactive tracer-guided procedure that facilitates identification, removal, and pathologic examination of the sentinel lymph node (i.e., the lymph node first receiving lymphatic fluid from the area of the breast containing the tumor) to predict the status of the axilla and to assess the safety of foregoing axillary dissection if the sentinel lymph node shows no involvement. METHODS: We injected 5-10 MBq of 99mTc-labeled colloidal particles of human albumin peritumorally in 376 consecutive patients with breast cancer who were enrolled at the European Institute of Oncology during the period from March 1996 through March 1998. The sentinel lymph node in each case was visualized by lymphoscintigraphy, and its general location was marked on the overlying skin. During breast surgery, the sentinel lymph node was identified for removal by monitoring the acoustic signal from a hand-held gamma ray-detecting probe. Total axillary dissection was then carried out. The pathologic status of the sentinel lymph node was compared with that of the whole axilla. RESULTS: The sentinel lymph node was identified in 371 (98.7%) of the 376 patients and accurately predicted the state of the axilla in 359 (95.5%) of the patients, with 12 false-negative findings (6.7%; 95% confidence interval = 3.5%-11.4%) among a total of 180 patients with positive axillary lymph nodes. CONCLUSIONS: Sentinel lymph node biopsy using a gamma ray-detecting probe allows staging of the axilla with high accuracy in patients with primary breast cancer. A randomized trial is necessary to determine whether axillary dissection may be avoided in those patients with an uninvolved sentinel lymph node.  (+info)

"The FSGS factor:" enrichment and in vivo effect of activity from focal segmental glomerulosclerosis plasma. (3/2483)

A circulating causative factor has been postulated in focal segmental glomerulosclerosis (FSGS). It has been shown that serum or plasma from some FSGS increases glomerular albumin permeability (Palb) in vitro. Palb greater than 0.5 (i.e., FS activity) is associated with recurrence after transplantation. Specimens from 15 FSGS patients were studied to document the presence of a permeability factor, to isolate this factor, to characterize its biochemical properties, and to show its effect in vivo. Total lipids were extracted by chloroform/methanol (2: 1); FS activity was absent from total lipid extract. Chylomicrons and lipoproteins were removed from the plasma with dextran sulfate, followed by sequential precipitation of proteins at 50 and 70% ammonium sulfate saturation. FS activity was retained in the 70% ammonium sulfate supernatant and exhibited a 100-fold purification. FS activity was lost after heating at 100 degrees C for 10 min or after protease digestion. Under nondenaturing conditions, electrophoresis of the FSGS 70% supernatant showed a prominent low molecular weight band that was not evident in the 70% supernatant from normal plasma. Dialysis and centrifugation-based membrane ultrafiltration of the FSGS factor indicated a molecular size between 30 and 50 kD. Injection of the 70% FSGS supernatant into rats caused a threefold increase in urine protein in collections from 6 to 24 h after injection. No increase in proteinuria occurred in rats injected with 70% supernatant from normal individuals. It is concluded that the FSGS factor is a low molecular weight protein with the potential to increase Palb in vitro and to cause proteinuria in vivo.  (+info)

Triacylglycerol biosynthesis in rat adipose-tissue homogenates. (4/2483)

The optimum cofactor requirements for triacylglycerol biosynthesis in rat adipose-tissue homogenates containing mitochondrial, microsomal and cytosolic fractions were investigated. In general the optimum concentrations of cofactors for triacylglycerol biosynthesis were found to differ from those for total fatty acid esterification. The results provided further evidence for the key role of phosphatidate phosphohydrolase in the regulation of triacylglycerol biosynthesis. Albumin was included in the incubation medium to permit the use of concentrations of added fatty acids that would swamp the effects of endogenous fatty acids. The addition of albumin had little effect on the incorporation of palmitic acid and stearic acid into lipids including triacylglycerols. By contrast, a critical concentration of albumin (about 60 muM) was required before incorporation of oleic acid or linoleic acid into triacylglycerols occurred. The system was used to study the incorporation of different 1-14C-labelled fatty acids from a mixture of unesterified fatty acids [palmitic acid 30%; stearic acid 10%; oleic acid 40%; linoleic acid 20% (molar percentages)] separately into the positions 1,2 and 3 of triacyl-sn-glycerols. In general the stereo-specific distribution of the labelled fatty acids incorporated into triacylglycerols paralleled the normal distribution of fatty acids within rat adipose-tissue triacylglycerols, suggesting that the specificities of the relevant acyltrasferases have the major role in determining the positional distribution of fatty acids within triacylglycerols.  (+info)

von Willebrand factor contained in a high purity FVIII concentrate (Fanhdi) binds to platelet glycoproteins and supports platelet adhesion to subendothelium under flow conditions. (5/2483)

BACKGROUND AND OBJECTIVE: There is evidence suggesting that von Willebrand factor (VWF) from high purity factor VIII concentrates could be of clinical use in the management of patients suffering from VWD. We analyzed structural and functional characteristics of VWF present in a high purity factor VIII concentrate VWFHPC (Fanhdi). The multimeric structure, the ability to bind to platelet GP Ib/IX or GP IIb/IIIa, and the capacity of VWFHPC to promote platelet adhesion on injured vessels were investigated and compared with that present in standard plasma cryoprecipitates [VWFCRYO]. DESIGN AND METHODS: Binding studies were carried out by incubating radiolabeled VWF and washed platelets, which were activated with either ristocetin (1 mg/mL; for GP Ib/IX), or thrombin (2.5 U/mL; for GP IIb/IIIa). Platelet adhesion was assessed in a perfusion system (shear rate = 800 s-1, 10 min) in which the source of VWF was added (at 0.4 or 0.8 U/mL VWF:Ag) to washed platelets and red cells suspended in a human albumin solution. The deposition of platelets onto the perfused subendothelial surface was morphometrically evaluated and expressed as percentage of surface coverage (%SC). RESULTS: The VWFHPC (152 Units VWF:RCof/mg protein; VWF:RCof/VWF:Ag = 0.97), lacked only a small proportion of high-molecular-weight multimers present in VWFCRYO. Binding affinities (Kd values, nM) of VWFHPC were similar to those of VWFCRYO (5.3 +/- 0.86 vs 5.2 +/- 0.95, for GP Ib/IX; and 11.6 +/- 2.7 vs 15.4 +/- 1.7 for GPIIb-IIIa). A slightly, though not significantly, higher binding capacity for these receptors (Bmax values, molecules/pit) was obtained for VWFHPC. The %SC in perfusions in the presence of albumin was < 10%. Addition of VWFHPC or VWFCRYO significantly increased the %SC, with values of 27.1 +/- 4.9 and 17.5 +/- 2.8%, respectively with 0.4 U/mL (p < 0.004 and p < 0.02 vs albumin); and 30.8 +/- 4.9% and 20.03 +/- 4.1%, respectively, at 0.8 U/mL (p < 0.001 and p < 0.02 vs albumin). INTERPRETATION AND CONCLUSIONS: Our data show that VWF present in the high purity FVIII concentrate Fanhdi retains the functional capacity to bind to GPs Ib/IX and IIb/IIIa and to promote platelet adhesion onto exposed subendothelium.  (+info)

Secretory cells of the peripheral pulmonary epithelium as targets for toxic agents. (6/2483)

The extracellular lining of the pulmonary peripheral airways is of vital importance to the lung. In this report, some aspects of the pulmonary extracellular lining and the epithelial cells believed to be responsible for its formation and secretion have been briefly reviewed. The influence of a number of toxic agents on the extracellular lining either directly or via those cells involved in its formation indicates that the extracellular lining may be important in understanding numerous toxic agent interactions with the lung.  (+info)

Peritoneal clearance of leptin in CAPD patients: impact of local insulin administration. (7/2483)

INTRODUCTION: The ob gene product leptin is secreted by fat cells and the serum leptin levels reflects the body fat content. Markedly elevated serum leptin levels have been reported in patients with chronic renal failure. The aim of the present study was to assess if the dialysate leptin levels in peritoneal dialysate are similar to what can be expected from passive diffusion or if intraperitoneal synthesis of leptin may occur. METHODS: We studied 39 patients (20 males), mean age 54+/-12 years, who had been treated with peritoneal dialysis for 17+/-12 months. Ten of the patients were diabetics of which seven used intraperitoneal insulin. A 24-h collection of dialysate was performed and dialysate and fasting blood samples were analysed for leptin, albumin and beta2-microglobulin, and the peritoneal clearances (PCl) were calculated for these solutes. RESULTS: Serum leptin (mean 47+/-76, range 3-350 ng/ml) was related to body mass index (r=0.35, P<0.05). In multiple regression analysis, serum leptin also correlated to serum TNF-alpha. Although dialysate leptin levels correlated to serum leptin, they were higher than expected from the molecular weight of 16 kD. PCl of leptin was 1.3 ml/min (range 0.2-5.9 ml/min), which was 1.6 times higher than expected from the molecular weight of leptin and PCl for albumin and beta2-microglobulin, not taking the protein binding of leptin into account. A strong correlation was found between PCI for albumin and beta2-microglobulin (r = 0.68, P < 0.0001) but neither PCl albumin, nor PCl beta2-microglobulin correlated to PCI leptin. The PCl of leptin was markedly higher in diabetics using intraperitoneal insulin (n = 7) compared to the other 32 patients (2.6+/-2.0 vs 1.1+/-0.7 ml/min, P<0.05). CONCLUSION: Serum leptin is locally produced in the peritoneal cavity, and intraperitoneal insulin enhances local production of leptin.  (+info)

The cytotoxicity of mafosfamide on G-CSF mobilized hematopoietic progenitors is reduced by SH groups of albumin--implications for further purging strategies. (8/2483)

The efficacy of mafosfamide purging depends on factors like incubation time, drug and erythrocyte concentration. To determine the influence of protein-bound SH groups in the incubation medium, the cytotoxicity of mafosfamide on G-CSF mobilized CD34+/- cells was evaluated by short-term culture assays and drug concentration measurements. 100 micromol/ml mafosfamide was incubated for 30 min in five buffers (PBS, PBS with 1%, 5% and 10% BSA and plasma). The mean calculated areas under the concentration-time curves (AUC) were 2489 +/- 198, 1561 +/- 286, 976 +/- 201, 585 +/- 62 and 605 +/- 196 micromol/l/min. The mean reductions of CFU-GM growth were 79.4%, 73.0%, 62.5%, 30.3%, 6.2% respectively. Similar results were obtained for BFU-E. Regression analysis showed a good correlation between cytotoxicity and AUCs (CFU-GM: r = 0.8195; BFU-E: r = 0.8207). This effect is well explained by the different concentrations of SH moieties in the incubation medium resulting in a higher drug binding capacity. The profound difference between AUCs and CFU-GMs in plasma and 10% BSA cannot be explained by the quantity of SH-groups. It is probably due to an additional enzymatic drug degeneration by the 3'-5'exonuclease subsite of plasma DNA polymerase. In conclusion, the concentration of albumin-associated SH groups strongly influences the cytotoxicity of mafosfamide. It has to be considered as a new and important aspect in ex vivo bone marrow purging.  (+info)

*Lymphangiectasia

With a very low serum albumin, transfusion with blood plasma or an infusion of hetastarch may be necessary to treat the signs ... chronic diarrhea and loss of proteins such as serum albumin and globulin. It is considered to be a chronic form of protein- ...

*Congenital nephrotic syndrome

Due to the protein (albumin) losses many patients have reduced muscle tone and may experience delays in certain physical ... Most patients will undergo regular and frequent albumin infusion (often daily) to replace what kidneys have lost. Infusions are ... Congenital nephrotic syndrome can be successfully controlled with early diagnosis and aggressive treatment including albumin ... albumin) in the urine. Antibiotics may be needed to control infections. Patients may also take iron supplements, potassium ...

*Albumin

Cohn process (human serum albumin purification method) Serum albumin Bovine serum albumin Human serum albumin This article ... Specific types include: human serum albumin bovine serum albumin (cattle serum albumin) or BSA, often used in medical and ... Albumins at the US National Library of Medicine Medical Subject Headings (MeSH) The Albumin website Albumin binding prediction ... Albumin binds to the cell surface receptor albondin. Serum albumin is the main protein of human blood plasma. It binds water, ...

*Blood proteins

Serum albumin accounts for 55% of blood proteins, and is a major contributor to maintaining the osmotic pressure of plasma to ...

*Protein losing enteropathy

Therefore, it is useful to categorize patients based on their serum albumin levels, if less than normal (typically less than ...

*CSF albumin

... is a measurement used to determine the levels of albumin in cerebrospinal fluid. A closely related test, CSF total ... It combines the albumin, IgG, and other proteins. It can be useful in distinguishing among causes of Meningitis. It is more ...

*Ovandrotone albumin

... (INN, BAN) (brand names Fecundin, Ovastim), also known as polyandroalbumin, as well as ovandrotone:human ... Indeed, ovandrotone albumin has been found to significantly increase luteinizing hormone levels throughout the estrous cycle in ... It is a conjugate of ovandrotone (androstenedione-7α-carboxyethylthioether) and human serum albumin. The drug was developed by ... Ovandrotone albumin produces transient immunity against androstenedione, and the generation of antibodies against ...

*Albumin I

... (PA1b) is a hormone-like peptide found in the seeds of legumes such as the pea plant (Pisum sativum) or soya bean ( ... "Molecular Requirements for the Insecticidal Activity of the Plant Peptide Pea Albumin 1 Subunit b (PA1b)". Journal of ...

*Serum albumin

... , often referred to simply as blood albumin, is an albumin (a type of globular protein) found in vertebrate blood ... Serum albumin is widely distributed in mammals. The human version is human serum albumin. Bovine serum albumin, or BSA, is ... Nephrotic syndrome patients are sometimes given albumin to replace the lost albumin. The general structure of albumin is ... Human serum albumin is encoded by the ALB gene. Other mammalian forms, such as bovine serum albumin, are chemically similar. ...

*Bovine serum albumin

... (also known as BSA or "Fraction V") is a serum albumin protein derived from cows. It is often used as a ... Acceptable daily intake Protein allergy Human serum albumin Serum albumin Ge S, Kojio K, Takahara A, Kajiyama T (1998). "Bovine ... "Albumin from bovine serum" (PDF). Sigma-Aldrich. Retrieved 5 July 2013. Axelsson I (May 1978). "Characterization of proteins ... The process was first commercialized with human albumin for medical use and later adopted for production of BSA. The full- ...

*Radioiodinated serum albumin

... , abbreviated RISA, is a marker used in identifying blood plasma via the dilution method in renal ... "Radioiodinated Albumin (Systemic)". Retrieved 23 December 2013. (Archived) Further reading Brocklehurst, G (1968). "Use of ... Hibbard, B. M. (1961). "Placental Localization Using Radio-Iodinated Serum Albumin (R.i.s.a.)1". BJOG: an International Journal ... "Comparison of the radioiodinated serum albumin (RISA) dilution technique with direct volumetric measurements in animal models ...

*Human serum albumin

Human Albumin structure in the Protein data bank Human Albumin information in the Swis-Prot/TrEMBL database Human Serum Albumin ... Human serum albumin has been shown to interact with FCGRT. Bovine serum albumin Serum albumin "Harmonisation of Reference ... The lost albumin can be detected by a simple urine test. Depending on the amount of albumin lost, a patient may have normal ... The Albumin Reviewers (Alderson P, Bunn F, Li Wan Po A, Li L, Pearson M, Roberts I, Schierhout G). Human albumin solution for ...

*Surfactant-albumin ratio

The surfactant-albumin ratio is a test for assessing fetal lung maturity. The test, no longer commercially available, used an ... Higher amounts of lecithin - in reference to albumin - is indicative of lung maturity (and thus survival of the neonate). When ... the Standards of Laboratory Practice set the threshold for lung maturity at 55 mg of lecithin per gram of albumin. Liu KZ, Shaw ... and albumin in such a way that direct quantitative measurements of both substances could be attained. ...

*Technetium (99mTc) albumin aggregated

After being allowed to set at room temperature for 15 minutes to ensure maximum tagging of 99mTc to the human albumin, the kit ... No less than 90% of the radioactivity present in the product must be tagged to albumin particles. Thus, no more than 10% ... It consists of a sterile aqueous suspension of Technetium-99m (99mTc) labeled to human albumin aggregate particles. It is ... Technetium 99mTc macro aggregated albumin (99mTc-MAA) is an injectable radiopharmaceutical used in nuclear medicine. ...

*CSF/serum albumin ratio

... is a test performed to compare the levels of albumin in the cerebrospinal fluid and the serum. It is ... Anckarsäter H, Forsman A, Blennow K (July 2005). "Increased CSF/serum albumin ratio: a recurrent finding in violent offenders ...

*Serum-ascites albumin gradient

The formula is as follows: SAAG = (serum albumin) − (albumin level of ascitic fluid). Ideally, the two values should be ... concentrating the serum albumin. The albumin does not move across membrane spaces easily because it is a large molecule. A high ... The serum-ascites albumin gradient or gap (SAAG) is a calculation used in medicine to help determine the cause of ascites. The ... which in turn forces water into the peritoneal cavity but leaves proteins such as albumin within the vasculature. Important ...

*Zafirlukast

... is highly plasma protein bound, 99% bound to albumin. Albumin is a the most abundant protein found in human plasma ... "plasma albumin". TheFreeDictionary.com. Saunders. Retrieved 7 January 2018. Vries, Helga E. de; Kuiper, Johan; Boer, Albertus G ...

*Alpha-Parinaric acid

For example, this technique is used to investigate how fatty acids bind to serum albumin (a highly abundant blood protein), ... Berde CB, Hudson BS, Simoni RD, Sklar LA (January 1979). "Human serum albumin. Spectroscopic studies of binding and proximity ... which will compete for binding sites on serum albumin. α-Parinaric acid has been used to study the hydrophobicity and foaming ... binding to bovine serum albumin". Biochemistry. 16 (23): 5100-8. doi:10.1021/bi00642a024. PMID 911814. ...

*Enzyme replacement therapy

Poznansky, M. J. (1984). "Enzyme-albumin polymers. New approaches to the use of enzymes in medicine". Applied biochemistry and ...

*Albumen (disambiguation)

Albumin is a class of several hundred proteins. Albumen or Albumin may also refer to: Serum albumin, a protein, encoded by the ... by The Egg Human serum albumin - the human variant Bovine serum albumin - the cow variant Endosperm, tissue produced in the ... "Albumin" All pages with a title containing Albumin. ...

*The Torment

... (albumin sivuviitteet). Retroactive Records. 2006. Album at Metal Archives. ...

*Intravenous therapy

Crystalloids generally are much cheaper than colloids.(blood, albumin, plasma, etc.) Volume expanders may either be isotonic, ...

*Let's Go to Bed (No Angels song)

"Polydor schickt zweites No Angels-Album ins Rennen". Musikwoche (in German). Mediabiz. June 14, 2002. Retrieved August 25, 2013 ...

*Still in Love with You (No Angels song)

"Polydor schickt zweites No Angels-Album ins Rennen". Musikwoche (in German). Mediabiz. June 14, 2002. Retrieved August 25, 2013 ...
Abraxane use in ovarian cancer, abraxane with tykerb, abraxane billing code, abraxane blood brain barrier and abraxane oncology. Abraxane carboplatin, abraxane mixing, abraxane 2008 sales and abraxane gradishar or abraxane cost.
The use of hyperoncotic albumin (HA) for shock resuscitation is controversial given concerns about its cost, effectiveness, and potential for nephrotoxicity. We evaluated the association between early exposure to hyperoncotic albumin (within the first 48 h of onset of shock) and acute organ dysfunction in post-surgical patients with shock. This retrospective, cohort study included 11,512 perioperative patients with shock from 2009 to 2012. Shock was defined as requirement for vasopressors to maintain adequate mean arterial pressure and/or elevated lactate (| 2.2 mmol/L). Subsets of 3600 were selected after propensity score and exact matching on demographics, comorbidities, and treatment variables (| 30). There was a preponderance of cardiac surgery patients. Proportional odds logistic regression, multivariable logistic regression or Cox proportional hazard regression models measured association between hyperoncotic albumin and acute kidney injury (AKI), hepatic injury, ICU days, and mortality.
OBJECT: Human albumin is used to induce hypervolemia (central venous pressure [CVP] , 8 mm Hg) after subarachnoid hemorrhage (SAH). Unfortunately, human albumin may increase the mortality rate in critically ill patients; because of this, its use became restricted in the authors hospital in May 1999. The goal of this study was to determine the effect of human albumin on outcome and cost in patients with SAH before and after this restriction was put into place. METHODS: All patients with aneurysmal SAH who were admitted to the authors institution between May 1998 and May 2000 were studied. Basic demographic information, dosage of human albumin given, length of stay, and the incidence of in-hospital deaths and complications were collected. The authors obtained Glasgow Outcome Scale (GOS) scores at 3 months after SAH (good outcome, GOS , or = 4). Data were analyzed using t-test and chi-square analysis. Logistic regression was used to identify independent associations between use of human albumin ...
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Diabetes is accompanied by dysregulation of glucose, lipid, and protein metabolism. In recent years, much effort has been spent on understanding how insulin regulates glucose and lipid metabolism, while the effect of insulin on protein metabolism has received less attention. In diabetes, hepatic production of serum albumin decreases, and it has long been established that insulin positively controls albumin gene expression. Yet, the detailed pathway via which insulin exerts this effect has not been described. In this study, we used a genetic approach in mice to identify the mechanism by which insulin regulates albumin production, both transcriptionally and post-transcriptionally. Albumin expression was significantly decreased in livers with insulin signaling disrupted by ablation of insulin receptor or Akt. Concomitant deletion of Forkhead Box O1 (Foxo1) in these livers rescued the decreased albumin secretion. Furthermore, expressing a constitutively active Foxo1 in the liver is sufficient to suppress
5438 Background: Docetaxel (Taxotere) is currently formulated in the surfactant Tween 80. Removal of surfactants from taxane formulations e.g., in the case of nanoparticle albumin-bound paclitaxel (Abraxane) resulted in significantly higher response rates and greater safety (Gradishar, JCO, 2005, 23:7794). Tween 80 strongly inhibited the binding of taxanes to albumin, possibly inhibiting albumin based drug transport via the gp60 endothelial receptor (Desai, EORTC-NCI-AACR, 2004) and consequent reduction of albumin-binding to tumor secreted SPARC. Herein, we compared the efficacy, toxicity, and pharmacokinetics (PK) of nab-docetaxel vs Taxotere. Methods: Nanoparticle nab-docetaxel was prepared using nab technology and characterized. Nab-docetaxel and Taxotere were tested in vivo against HCT-116 human colon carcinoma xenograft in nude mice (n=10/group) at equitoxic doses of 22 mg/kg of nab-docetaxel and 15 mg/kg of Taxotere, on a q4dx3 schedule. Single dose toxicity (TOX) of nab-docetaxel was ...
article{8d460a00-2713-4df9-af4f-6169013fd070, author = {Bakoush, Omran and Tencer, Jan and Torffvit, Ole and Tenstad, Olav and Skogvall, Ingela and Rippe, Bengt}, issn = {1460-2385}, language = {eng}, number = {7}, pages = {1724--1731}, publisher = {Oxford University Press}, series = {Nephrology Dialysis Transplantation}, title = {Increased glomerular albumin permeability in old spontaneously hypertensive rats.}, url = {http://dx.doi.org/10.1093/ndt/gfh276}, volume = {19}, year = {2004 ...
Preclinical studies have recently shown that albumin has neuroprotective effects for stroke in animal models. Thus, we sought to evaluate the effects of albumin therapy in patients with acute cerebral infarcts. We prospectively studied 49 patients with moderate-to-severe cerebral infarcts within the middle cerebral arterial territory into one of two groups: the control group (N = 18) received saline, whereas the albumin group (N = 31) received either 40 g or 80 g of albumin within 24 h from symptom onset.. The modified National Institutes of Health Stroke Scale (mNIHSS) and diffusion-weighted imaging (DWI) were serially checked. There was no adverse effect related to albumin therapy. Although there was no significant difference in both baseline mNIHSS score and DWI lesion volume on admission, the mNIHSS scores at the 14(th) day after treatment and the increase in DWI lesion volume 72-96 h after treatment were significantly reduced in patients of the albumin group (p = 0.001 and 0.012, ...
[126 Pages Report] Check for Discount on Global Albumin-based Sealants Sales Market Report 2016 report by QYResearch Group. Notes: Sales, means the sales volume of Albumin-based Sealants...
Purpose: Circulating Tumor cells (CTC) are prognostic in metastatic breast cancer (MBC). We tested whether EpCAM based capture system (CellSearch®) is effective in patients with triple negative (TN) MBC, and whether CTC-apoptosis and clustering enhances the prognostic role of CTC. Experimental Design: CTC enumeration and apoptosis was determined using the CXC CellSearch® kit at baseline and days 15 and 29 in blood drawn from TN MBC patients who participated in a prospective randomized phase II trial of nanoparticle albumin-bound paclitaxel (nab-PAC) with or without tigatuzumab (TIG). Association between levels of CTC and patient outcomes was assessed using logistic regression, Kaplan Meier curves, and Cox proportional hazards modeling. Results: Nineteen of 52 (36.5%), 14/52 (26.9%), and 13/49 (26.5%) patients who were evaluable had elevated CTC (≥5CTC/7.5 ml WB) at baseline, days 15 and 29, respectively. Patients with elevated vs. not elevated CTC at each time point had worse progression ...
Biocon Limited, Indias pioneering biotechnology company, and Abraxis BioScience, Inc. (NASDAQ:ABII), a fully integrated biotechnology company, today announced the launch of ABRAXANE(R) (paclitaxel protein-bound particles for injectable suspension) (albumin-bound) in India for the treatment of breast cancer after failure of combination therapy for metastatic disease or relapse within six months of adjuvant chemotherapy. ABRAXANE is now available in India as a single-use 100 mg vial (as a lyophilized powder, to be reconstituted for intravenous administration). In October 2007, ABRAXANE was approved by the Drug Controller General of India. The approval was based on the clinical trial data that was the basis of approval in the United States. The Phase III clinical trial in the U.S. demonstrated that ABRAXANE nearly doubled the response rate, significantly prolonged time to progression, and significantly improved overall survival in the second-line setting versus solvent-based Taxol(R) in the ...
Introduction- Exercise-induced plasma volume (PV) expansion is typically associated with an increase in plasma albumin content. Increased hepatic albumin synthesis, a transcriptionally regulated process, is thought to contribute to the increase in albumin content. Objective- We tested the hypothesis that exercise training induces an increase in albumin gene expression in relationship to the increase in PV. Methods and Results- 40 adult male Sprague-Dawley rats weighing between 245-350 grams were randomly assigned to one of four groups: cage control (CC); sham exercise 10 min/day at 48% VO2max (NE); continuous exercise training, 60 min /day at 72% VO2max (LI); and high intensity, intermittent exercise training, 8 bouts of 4 min at 98% VO2max followed by 5 min at 48% VO2max (HI). The training period lasted for two weeks with 12 training sessions with equalized training volumes in the exercise groups. 24 hours after the last training session the rats were anesthetized and a jugular catheter was placed for
Decreased albumin synthesis by hepatocytes in liver injury is thought to occur in response to Kupffer cell-derived acute-phase cytokines. In this study we used hepatocytes maintained in a differentiated phenotype, by culture on a laminin-rich gel substratum (Engelbreth-Holm-Swarm matrix), to investigate the effects of Kupffer cell-conditioned medium and purified cytokines (interleukin-1, interleukin-6 and tumor necrosis factor-a) on albumin synthesis. Kupffer cell-conditioned medium caused a reversible decrease in albumin synthesis to 64.7% of control (p , 0.01, Wilcoxons rank sum test, n = 11) on day 2. Repeated doses caused further dose-dependent reversible responses. The same result was obtained when protease inhibitors (α1-antitrypsin and α2-macroglobulin) were added to Kupffer cell-conditioned medium (n = 3), thus eliminating the potential effect of matrix degradation. Pure interleukin-1, interleukin-6 and tumor necrosis factor-α also inhibited albumin synthesis (p , 0.05, Wilcoxons ...
Current guidelines as those from the AGO-Breast commission recommend for neoadjuvant breast cancer patients either a sequence of 4 cycles EC followed by 4 cycles of a taxane or 6 cycles of TAC based on previous large scale studies.. Treatment of patients with HER2-positive disease should include also simultaneous application of trastuzumab.. Solvent-based taxanes (paclitaxel, docetaxel) cause severe toxicities not only by the active agents itself but also by the solvents like cremophor. Nab-paclitaxel (Abraxane®) is a solvent-free formulation of paclitaxel encapsulated in albumin. It does not require premedication with corticosteroids or antihistamines to prevent the risk of solvent-mediated hypersensitivity reactions. This new formulation improves safety profile, allows higher dosing with shorter infusion duration, and produces higher tumor drug concentration.. As neoadjuvant treatment does not only allow to compare competing treatment approaches with a very high quality (homogenous treatment ...
The phase III clinical trials in the US and China on which this approval was based demonstrated that Abraxane doubled the response rate, significantly prolonged time to tumour progression, and in the US trial, significantly improved overall survival versus Taxol in the approved indication.. Data from the US pivotal head-to-head trial demonstrated that Abraxane nearly doubled the overall response rate versus Taxol (33% vs. 19%; P = .001) and achieved a 25% percent improvement in time to tumour progression when compared to Taxol. Furthermore, patients receiving Abraxane in the second-line setting had a significantly prolonged survival by an additional 27% compared to solvent-based Taxol. The tolerability with Abraxane and Taxol was comparable, despite the 50% greater dose of paclitaxel administered as Abraxane.. A second head-to-head trial in Chinese patients with metastatic breast cancer further demonstrated the improved efficacy of Abraxane compared to solvent-based Paclitaxel Injection. ...
Next article in issue: Detection of albumin messenger RNA in blood is not restricted to hepatocellular carcinoma Next article in issue: Detection of albumin messenger RNA in blood is not restricted to hepatocellular carcinoma ...
Nanoparticle albumin-bound (nab)-paclitaxel, an albumin-bound-stabilised paclitaxel formulation, has recently demonstrated significant improvements in median survival of patients with metastatic PDA when combined with gemcitabine.18 Since this drug combination represents the first therapeutic regimen that significantly extends survival of advanced stage PDA patients and is accompanied by an acceptable toxicity profile, nab-paclitaxel and gemcitabine will likely become the new standard of care chemotherapy and will shortly be implemented in national and international PDA treatment guidelines. Apart from the striking antitumour effect of nab-paclitaxel alone in KPC tumours, our group previously discovered a potential synergistic drug-drug interaction of gemcitabine and nab-paclitaxel due to ROS-mediated degradation of cytidine deaminase that resulted in higher levels of activated intratumoural gemcitabine metabolites.19 However, the limited availability of patient tissue and the lack of murine ...
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Abraxane® (nab-paclitaxel) prolonged life in patients with metastatic pancreatic cancer by an average of two months longer than chemotherapy and significantly increased the percentage of patients who survived for up to two years, according to the results of a study presented at the 2013 Gastrointestinal Cancers Symposium in San Francisco.. Pancreatic cancer is one of the deadliest forms of cancer. Each year, approximately 43,000 people are diagnosed with pancreatic cancer in the United States and close to 37,000 die from the disease. The disease is often diagnosed at an advanced stage, and treatment of advanced disease remains challenging.. Gemzar® (gemcitabine) has been a standard chemotherapy drug for the treatment of advanced pancreatic cancer for some time. Abraxane is a novel form of the widely used cancer drug Taxol (paclitaxel). In Abraxane, the paclitaxel is bound to albumin, a human protein in tiny particles. This formulation improves the delivery of the drug directly to cancer cells ...
How fast do we infuse albumin? Is it 30 minutes or 1 hour or 2 hours? Special long tubing-a primary tubing comes from pharmacy. I thought it would be secondary tubing. It has that rolling drip
Rabbit plasma albumin was labelled with I131, injected intravenously, and measurements were made of the radioactivity in plasma, urine, and feces over many days. In some experiments plasma radioactivity was fractionated into I131-albumin activity and that of labelled breakdown products. Curves of these radioactivities were compared with corresponding curves predicted by four mathematical models. Each model included a vascular and extravascular albumin compartment in transfer equilibrium, a radioactive breakdown products compartment, and an excretion compartment; but model A supposed I131-albumin catabolism to occur within the vascular system, model B within the extravascular compartment, model C within both, and model D within a separate compartment receiving albumin for catabolism from the plasma. The experimental data were reasonably well predicted by models A and C. However, model D, though data were insufficient for its complete validation, gave the best predictions and agrees with present ...
Patients will receive 2 cycles of gemcitabine and abraxane prior to the start of chemoradiation. Chemoradiation will commence 2 week after the completion of second cycle of gemcitabine/abraxane. Patients will receive an additional 2 cycles of gemcitabine and abraxane to start 2-4 weeks after the completion of chemoradiation. After the last two cycles of chemotherapy, if well tolerated with continued tumor response additional cycles of chemotherapy may be given ...
The review by Wilkes and Navickis is the 13th meta-analysis evaluating the effect of fluids on mortality in seriously ill patients. The strengths of this meta-analysis are the comprehensive search strategies used to identify primary studies, which minimised publication and English language bias; the explicit selection criteria used; the use of methodological quality, such as random assignment, as an inclusion criterion; extraction of data in duplicate; and rating of treatment allocation, crossovers, and blinding for each included study. However, all relevant co-interventions, such as blood products, were not well reported in the original trials. 23 of 78 potentially eligible studies were excluded because no mortality data were available, highlighting how many trials were designed to address short term physiological endpoints.. In this meta-analysis, the relative risk (RR) of mortality for all patients was 1.11 (table⇑). Subgroup analyses were planned a priori, and included surgery or trauma ...
Sigma-Aldrich manufactures & distributes different types of albumins. We offer serum albumins purified from a variety of primary methods.
Gentaur molecular products has all kinds of products like :search , AbD \ RABBIT ANTI MOUSE ALBUMIN, Product Type Polyclonal Antibody, Specificity ALBUMIN, Target Species Mouse, Host Rabbit, Format Serum, Isotypes Polyclonal IgG, Applications ID, WB, Clone \ 0220-1829 for more molecular products just contact us
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Although gemcitabine exhibits potent cytotoxicity against PDA cells in vitro, its short half-life may contribute to its relatively weak antitumor activity in vivo. Indeed, methods that increase gemcitabine delivery (3) or stability (22) have been proposed to circumvent this problem clinically. Taxanes are also active in pancreatic cancer xenografts and patients, although treatment is limited by systemic toxicity (23, 24). nab-Paclitaxel is a solvent-free formulation composed of paclitaxel and human albumin with a mean particle size of 130 nm. It offers several advantages over solvent-based paclitaxel, including increased water solubility that obviates Cremophor EL-based toxicities. In addition, albumin is hypothesized to target paclitaxel to stromal-rich tumors and thereby increase the local concentration. Although combinations of gemcitabine and taxanes have demonstrated antitumor activity in patients with PDA, its toxicity has limited its use in the clinic (25). Accumulating clinical data ...
The Therapeutic Goods Administration (TGA) has taken steps today to quarantine CSL Human Albumin solutions from further use while an asse
Relationship between ischemia/reperfusion-induced albumin clearance across the mucosa of the small intestine and the reduction in oxygen consumption induced during the ischemic period. Used with permission from Gastroenterology 1985; 89: pp. 852-857.
In the last few years, the involvement of EC caveolae in transcytosis of macromolecules from the blood to the tissue has been addressed using the caveolin-1-deficient mice (195, 196). Studies of caveolin-1-deficient mice indicated a profound dysfunction of the vascular system (aberrations in the endothelium-dependent relaxation, contractility, maintenance of the myogenic tone, and, as a consequence, reduced physical ability), significant cardiopulmonary pathology including cardiomyopathy, pulmonary hypertension, thickening of the alveolar septa by uncontrolled EC proliferation, and lung interstitial fibrosis (37). Despite lack of caveolae, the albumin concentration in the cerebrospinal fluid and the extravascular oncotic pressure were normal. This finding suggested that an alternative pathway might compensate for albumin transport (37). Studies examining in detail albumin transport across the vasculature of mice devoid of caveolin-1 and caveolae indicated that radioiodinated albumin was not ...
albumin - MedHelps albumin Center for Information, Symptoms, Resources, Treatments and Tools for albumin. Find albumin information, treatments for albumin and albumin symptoms.
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The National Institute for Health and Care Excellence has published new recommendations rejecting the use of Celgene’s Abraxane (nab-paclitaxel) on the National Health Service to treat patients with advanced pancreatic cancer. - News - PharmaTimes
Nexus Lifecare Pvt. Ltd. manufacturers, suppliers of anticancer drugs and anti cancer injections, Reditux Injection, Sorafenib, Herclon 440mg Injection, Abraxane 100mg Injection, Velcade Injection, Taxol injections, Kemocarb Injections, Lipodox injections in Mumbai.
Paclitaxel, Abraxane monotherapy is indicated for the treatment of metastatic breast cancer in adult patients who have failed first-line treatment for metastatic disease and for whom standard, anthracycline co
Phase II LAPACT trial results reported on the safety and efficacy of ABRAXANE + gemcitabine induction therapy on tumor burden, disease control, and symptoms SUMMIT, N.J.--(BUS...
Sorry for this but I feel I should ask a different question related to my other Thread. Here it is: Is anyone here aware of an insurance company refusing to cover Abraxane for Stage IV Pancreatic Cancer based in whether it was to be the first or second treatment?
Over 30 yr ago, glucosylated albumin was found to be present in normal human serum and increased in diabetes (13, 19). Soon afterward, it was reported that glucosylated albumin was handled differently than unmodified albumin, leading to the editing hypothesis, which proposed selective filtration and excretion of glucosylated albumin (17, 29, 30). This editing process was reduced in diabetic animals, and it was proposed that the proximal tubule may be the site of editing and that normal editing returned if blood glucose levels were controlled (29). Diabetes, aging, and other factor known to alter albumin may alter its interaction with renal proximal tubules independent of glomerular changes (9, 31, 49, 74). More recent data using the rat streptozotocin diabetes model showed no significant change in glomerular filtration but a significant decrease in albumin uptake by proximal tubules, supporting earlier studies that predicted that editing was done in the proximal tubule (50, 71). In the present ...
Kaplan-Meier plots of overall survival in the full analysis set of patients with unresectable or recurrent gastric cancer receiving nanoparticle albumin-bound
BSA, or bovine serum albumin, has a molecular weight of 66 kilodaltons. BSA is a serum albumin protein that is derived from cows. This protein is utilized in research laboratories as a protein...
Urine albumin trace - Hi my mom just did a nlood test and the results are HDL 35 Mg/dl LDL 103Mg/dl Albumin (+) (traces in urine) Are they related in some way please help? No. The results of cholesterol in the blood have no relation with the urine results. HDL is borderline low and LDL is slightly high, depending on the reference ranges of the lab you used. Also you did not mention how high the total cholesterol is, and if there is family history of heart disease. Trace albumin in the urine is commonly seen, not significantmay need repeat if your doctor is concerned.
Albumin is a protein made by the liver that makes up about 60% of the total protein in the blood and plays many roles in the body. An albumin test is routinely used to help evaluate a persons overall health status as part of a comprehensive metabolic panel (CMP) and may also be used to evaluate conditions such as liver or kidney disease.
Comparison of the supercooling preservation of rat hepatocytes with other preservation modalities in long term plate culture.Albumin secretion of cells preserve
Theres no detailed assessment of that. The investigators can argue that they have more context to interpret what perhaps will be ambiguous imaging findings. On the other hand, they (we) may also be more biased to interpret results as favorable because they want their patients to be doing well; they may also allow their clinical perception of how a patient is doing to affect their judgment of the findings on the scans. Its not completely clear whos more right or wrong, but we generally rely on the professional radiologists who comprise the independent reviewing committee as being more objective.. The company suggested that additional efficacy data would be available later this year. Ill admit that it makes me skeptical when a company has response rate data in March but doesnt have progression-free survival data, at least. There isnt that long of a lag between the first few scans and a detection of progression in many patients (unfortunately). Since we generally see that companies will shout ...
Purified Native Human Ischemia Modified Albumin (IMA) Protein from Creative Biomart. Native Human Ischemia Modified Albumin (IMA) Protein can be used for research.
Liverpoolin lääketieteellinen edelläkävijä, grind core-legenda Carcass julkaisee uuden albumin vuoden 2013 aikana. Yhtyeen ärisijä-basisti Jeff Walkerin Decibel-sivustolle antaman haastattelun perusteella uusi raatoalbumi on ollut jo tovin valmiina. Yhtyeen studiokokoonpanoon Walkerin lisäksi kuuluu alkuperäiskitaristi Bill Steer (ex-Napalm Death), ja rumpalin osuudet albumilla kolkuttava Daniel Wilding. Walker vihjailee myös yhtyeen alkuperäisen rumpalin Ken Owenin osallistumisesta albumin toteutukseen jossain määrin. Owen invalidisoitui pahanlaatuisen aivohalvauksen seurauksena vuonna 1999.. Livekokoonpanossaan yhtye tulee jatkamaan nelimiehisenä, mutta Walkerin sanoista päätellen ilmeisestikään kokoonpanossa ei tulla näkemään Arch Enemyssa vaikuttavia "nimimiehiä", Michael Amottia eikä myöskään 2000-luvulla Carcassissa mättänyttä rumpalia Daniel Erlandsonia.. Uuden Carcass-albumin on tuottanut metalliäänivelho Colin Richardson. Tuleva albumi on yhtyeen ...
Z-Scan technique: To measure the total protein and albumin in blood. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
Get an overview of VOLUMEX (iodinated i-131 albumin injection, solution), including warnings and precautions, directions, and the names of other drugs and products that include the same medication.
Albumin test is to check the level of protein in the blood which helps in diagnosing kidney or liver disease and checks whether the body is absorbing enough protein. Learn more
Learn about the known and possible side effects of Albumin Human Not everyone will experience one or all of these side effects. In case of any doubt please consult your doctor or pharmacist
Këngëtari i njohur Meti Maloku nuk po ndalet me realizimin e projekteve të reja. Bashkë me Trinota, Meti nxjerrë sot në shitje albumin muzikor, përcjellë zico.tv.. Këtë e ka bërë të ditur këngëtari gjilanas në rrjetin social Facebook.. ...
Umfassende Darstellung von medizinischen Laborparametern. Mehr als die H lfte aller Erkrankungen werden durch Laborparameter entdeckt oder im Verlauf kontrolliert.
Albumin synthesis was measured in the isolated perfused rat liver by using the livers of both well-fed and starved rats. Starvation markedly decreased albumin synthesis. The livers from starved rats were unable to increase synthesis rates after the addition to the perfusates of single amino acids or the addition of both glucagon and tryptophan. Arginine, asparagine, isoleucine, leucine, lysine, methionine, phenylalanine, proline, threonine, tryptophan and valine, added together to ten times their normal peripheral blood concentrations, restored synthesis rates to normal. The plasma aminogram (i.e. the relative concentrations, of amino acids) was altered by depriving rats of protein for 48h. The use of blood from the deprived rats as perfusate, instead of normal blood, decreased albumin synthesis rates significantly by livers obtained from well-fed rats. The addition of single amino acids, including the non-metabolizable amino acid, α-aminoisobutyric acid, to the above mixture increased albumin ...
Albumin is the most abundant plasma protein. Critical illness is often associated with altered, predominately decreased, serum albumin levels. This hypoalbuminaemia is usually corrected by administration of exogenous albumin. This study aimed to track the concentration-dependent influence of albumin on blood coagulation in vitro. Whole blood (WB) samples from 25 volunteers were prepared to contain low (19.3 ± 7.7 g/L), physiological (45.2 ± 7.8 g/L), and high (67.5 ± 18.1 g/L) levels of albumin. Haemostatic profiling was performed using a platelet function analyzer (PFA) 200, impedance aggregometry, a Cone and Platelet analyzer (CPA), calibrated automated thrombogram, and thrombelastometry (TEM). Platelet aggregation-associated ATP release was assessed via HPLC analysis. In the low albumin group, when compared to the physiological albumin group, we found: i) shortened PFA 200-derived closure times indicating increased primary haemostasis; ii) increased impedance aggregometry-derived amplitudes,
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Albumin was isolated from pooled fetal serum from 58 placentas obtained at normal delivery at term and from pooled adult plasma from 8 individuals. Albumin isolation was carried out by means of PEG precipitation followed by ion-exchange chromatography on DEAE-Sephadex A 50 and then on SP-Sephadex C 50. The electrophoresis on SDS-polyacrylamide gels showed only one spot that comigrated with commercial human albumin. Binding to albumin was measured by equilibrium dialysis of an aliquot of albumin solution (0.7 ml) against the same volume of 0.13 M sodium orthophosphate buffer (pH 7.4). At a total concentration of 2-mu-g/ml (therapeutic range), the unbound fraction of furosemide was 2.71% (fetal albumin) and 2.51% (adult albumin). Two classes of binding sites for furosemide were observed in fetal and adult albumin. The number of binding sites (moles of furosemide per mole of albumin) was 1.22 (fetal albumin) and 1.58 (adult albumin) for the high-affinity site and 2.97 (fetal albumin) and 3.25 ...
Albumin is the primary component of plasma proteins and accounts for 80% of colloid osmotic pressure. Its three domains determine the binding properties for several endogenous molecules and drugs. The cystein -SH residue accounts for its antioxidant properties and binding of nitric oxide, modulating its effect. The imidazole residues of 16 istidine molecules make albumin the most powerful buffer in the extravascular space. Plasma albumin concentration is a powerful dose-dependent predictor of mortality. Three relevant subsequent metanalysis, in sequence, found albumin administration harmful, neutral and advantageous. The blind, controlled and randomized SAFE study, performed in a large Intensive Care population, found similar outcomes in patient treated with 4% albumin or crystalloids for fluid resuscitation. The subgroup analysis showed a beneficial trend in septic patients treated with albumin and unfavourable trend in trauma patients with brain injury. Unfortunately albumin has been mainly ...
Albumins are a group of acidic proteins which occur plentifully in the body fluids and tissues of mammals and in some plant seeds. Unlike globulins, albumins have comparatively low molecular weights, are soluble in water, are easily crystallized, and contain an excess of acidic amino acids. Serum and plasma albumin is carbohydrate-free and comprises 55-62% of the protein present.. Albumin binds water, Ca2+, Na+, and K+. Due to a hydrophobic cleft, albumin binds fatty acids, bilirubin, hormones, and drugs. The main biological function of albumin is to regulate the colloidal osmotic pressure of blood. Human and bovine albumins contain 16% nitrogen and are often used as standards in protein calibration studies. Albumin is used to solubilize lipids, and is also used as a blocking agent in Western blots or ELISA applications. Globulin free albumins are suitable for use in applications where no other proteins should be present (e.g., electrophoresis).. ...
This work is a continuation of electrophoretic investigations aimed at revealing a wild relative ofVicia faba. Electrophoretic analysis (PAGE) of seed albumins covered 52 accessions representing eightVicia species of sect.Hypechusa and two species of sect.Peregrinae. Most of the examined species showed an intraspecific variation due to differences between accessions and/or individual variation within accessions. In spite of the intraspecific variation, marked interspecific differences were recorded. However, none of the investigated species displayed electrophoretic seed albumin patterns similar to those reported earlier forV. faba. Contribution of the obtained results to characterization of the examined taxa is discussed.
Low wall shear stress (WSS) is implicated in endothelial dysfunction and atherogenesis. The accumulation of macromolecules is also considered as an important factor contributing to the development of atherosclerosis. In the present study, a fluid-wall single-layered model incorporated with shear-dependent transport parameters was used to investigate albumin and low-density lipoprotein (LDL) transport in an in vivo computed tomographic image-based human right coronary artery (RCA). In the fluid-wall model, the bulk blood flow was modeled by the Navier-Stokes equations, Darcys law was employed to model the transmural flow in the arterial wall, mass balance of albumin and LDL was governed by the convection-diffusion mechanism with an additional reaction term in the wall, and the Kedem-Katchalsky equations were applied at the endothelium as the interface condition between the lumen and wall. Shear-dependent models for hydraulic conductivity and albumin permeability were derived from experimental ...
Serum albumin is the most abundant plasma protein and has a long half-life due to neonatal Fc receptor (FcRn)-mediated transcytosis by many cell types, including proximal tubule cells of the kidney. Albumin also interacts with, and is modified by, many small and large molecules. Therefore, the focus of the present study was to address the impact of specific known biological albumin modifications on albumin-FcRn binding and cellular handling. Binding at pH 6.0 and 7.4 was performed since FcRn binds albumin strongly at acidic pH and releases it after transcytosis at physiological pH. Equilibrium dissociation constants were measured using microscale thermophoresis. Since studies have shown that glycated albumin is excreted in the urine at a higher rate than unmodified albumin, we studied glucose and methylgloxal modified albumins (21 days). All had reduced affinity to FcRn at pH 6.0, suggesting these albumins would not be returned to the circulation via the transcytotic pathway. To address why ...
This study looks into the distinctions between albumin-water, natural rubber-hydroxide, blends of each plastic, and tensile properties of albumin concentration after application of tissue. With lower content of both water and glycerol, the two studies showed anti-inflammatory effect and accumulation effect. The second interaction between albumin was most likely due to the albumin protein itself. This peak albumin in the waters cell membrane could have been due to the presence of different polymers. For instance, the first peak seen at 30c was the initial degradation of the protein in the plastic. However, after the addition of moisture, the plastics maintained a high moisture content after 90 hours of molding. Overall, based on the previous data, it was found that after conditioning for 20h, the plastics would maintain consistent values.. This loss in moisture content was due to the loss of water from heat, using a larger plastic, and more. It could render this plastic frame useful for the ...
Urinary excretion of albumin indicates kidney damage and is recognized as a risk factor for progression of kidney disease and cardiovascular disease. The role of urinary albumin measurements has focused attention on the clinical need for accurate and clearly reported results. The National Kidney Disease Education Program and the IFCC convened a conference to assess the current state of preanalytical, analytical, and postanalytical issues affecting urine albumin measurements and to identify areas needing improvement. The chemistry of albumin in urine is incompletely understood. Current guidelines recommend the use of the albumin/creatinine ratio (ACR) as a surrogate for the erro-prone collection of timed urine samples. Although ACR results are affected by patient preparation and time of day of sample collection, neither is standardized. Considerable intermethod differences has been reported for both albumin and creatinine measurement, but trueness is unknown because there are no reference measurement
The addition of pyruvate to the culture medium has been reported to improve the maintenance of P450-dependent enzyme expression in primary rat hepatocyte cultures. In this study, the effects of 30mM pyruvate on cell morphology, albumin secretion and glutathione Stransferase (GST) expression were investigated as a function of the time in culture. The effect of triiodothyronine (T3) exposure on GST expression was also measured in pyruvate-treated cultures. Transmission electron microscopy showed that untreated hepatocytes deteriorated after culture for 7 days, whereas the morphology of the pyruvate-treated cells was similar to that observed in intact liver tissue. The albumin secretion rate was significantly higher in rat hepatocytes exposed to pyruvate than in control cells. In the presence of pyruvate, μ and α class GST activities were well maintained, whereas GST π activity was increased over the entire culture period. HPLC analysis revealed that the complement of GST subunits present in ...
Albumin is a blood protein. The word "albumin" comes from the Latin for egg white (egg white contains albumin, which is one reason why eggs are a rich source of protein). Albumin is produced in the liver. It is important in the maintenance of blood consistency and regulating blood pressure, and in the transmission of certain nutrients through the bloodstream. Its reasonable to say that this is a very important substance in the blood.. Test. A test for albumin is useful in the diagnosis of many different illnesses. Low levels of albumin can be an indicator of kidney dysfunction. Thats because healthy kidneys that are functioning properly leave albumin in the blood for the most part while removing waste substances. A low serum albumin level combined with the detection of higher than normal levels of albumin in urine shows that the kidneys are not doing this properly.. Causes. Other causes of low albumin include certain liver diseases such as liver cancer or hepatitis. This can interfere with the ...
What is Protein bound paclitaxel (Abraxane) ? Source: National Cancer Institute protein-bound paclitaxel (PROH-teen... PAK-lih-TAK-sil) A drug used to treat
After much discussion between the four of us (Me, Mark & Sarah) and Dr. Anderson, we are changing up my treatment plan after my chemo vaca week next week. Ill have a weekly infusion of Carboplatin (the dreaded one that sets me back so, but a much lower dose), along with a new drug, Abraxane. The Abraxane will cause me to have a new short cool do for the summer (baldness) :-), and possibly neuropathy. But we are looking to keep things moving in the right direction, since I have probably gotten the most out of the current plan at 4 cycles, and hopefully we will see tumor reduction of the breast with the change to Abraxane. It is hard on the blood too, so although it is a weekly infusion, Dr. Anderson says chances are Ill need a Nupagen shot now and then, which will add delays into the weekly schedule now and again. But the Abraxane should be easier to tolerate, even with the Carboplatin, since it will be a much smaller dose of that one ...
In this trial, the safety of combination treatment of Adriamycin plus cyclophosphamide followed by Abraxane as adjuvant therapy will be evaluated in pat
The degree of permeability of the blood-brain barrier can be evaluated by the quantitative measurements of albumin in the CSF and the serum on specimens obtained at the same time. Albumin is a particularly suitable indicator of protein because it is neither synthesized nor metabolized intrathecally. In CSF that is free of blood contamination, therefore, albumin must necessarily have come from plasma through the blood-brain barrier.. Using the results of quantitative CSF and serum albumin assays, a CSF (in mg/dL)/serum (in g/dL) albumin index can be calculated. An index value ,9 is considered consistent with an intact barrier. Values of 9-14 are interpreted as slight impairment, 14−30 as moderate impairment, and 30−100 as severe impairment. Values ,100 indicate complete breakdown of the barrier.1 ...
URINE Albumin Urine with protein or albumin is related to Hypertension or Diabetic. Kidneys normally prevent large molecules such as albumin from being excreted in the urine, high levels of urinary albumin excretion, called albuminuria, also indicates kidney is some how not functioning properly. It also reflects dysfunction of endothelial cells throughout the body, which…
International Protein Natural Egg White Albumen Protein is an easily absorbed whole food protein with an excellent amino acid profile which is still considered the gold standard of protein supplements. It is a medium release protein which makes it great for a betwee
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A liquid-activated formulation is provided, comprising a liquid-activated colorant, a hydrochromic ionic compound, an opacifier, and a solvent-based binding matrix.
Article New solvent-based process could dramatically reduce the cost and environmental impact of recovering oil from tar sands. Untitled Document A new Canadian technology shows promise as an environmentally-friendly way to extract oil...
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A) Diagram of a segment of aortic wall showing the regions in which tracer concentrations were measured. The intimal surface of the aortic wall is represented en face, with one intercostal branch ostium in the center. Mean aortic flow (heavy arrow) is from top to bottom. Serial longitudinal sections 2 μm thick were cut through the wall, perpendicular to the luminal surface, starting with a section along the midline (CC′ ). A notch scored on the surface of the block permitted correct alignment of sections in the longitudinal direction. Sections were cut until approximately 80 or 345 μm past the edge of the ostium (light arrows) to create narrow field and wide field maps, respectively. Bar=500 μm (B) Sections along the lines CC′ and DD′ are shown in diagrammatic form (the real section along DD′ is shown in Fig 3); in upstream and downstream regions of each section, the wall was divided into 6 strips, indicated by dotted lines in section CC′ ; tracer concentrations were averaged in the ...
TY - JOUR. T1 - An interstitial peptide is readily processed from within seed proteins. AU - Pouvreau, Benjamin. AU - Fenske, Ricarda. AU - Ivanova, Aneta. AU - Murcha, Monika W.. AU - Mylne, Joshua S.. PY - 2019/8/1. Y1 - 2019/8/1. N2 - The importance of de novo protein evolution is apparent, but most examples are de novo coding transcripts evolving from silent or non-coding DNA. The peptide macrocycle SunFlower Trypsin Inhibitor 1 (SFTI-1) evolved over 45 million years from genetic expansion within the N-terminal discarded region of an ancestral seed albumin precursor. SFTI-1 and its adjacent albumin are both processed into separate, mature forms by asparaginyl endopeptidase (AEP). Here to determine whether the evolution of SFTI-1 in a latent region of its precursor was critical, we used a transgene approach in A. thaliana analysed by peptide mass spectrometry and RT-qPCR. SFTI could emerge from alternative locations within preproalbumin as well as emerge with precision from unrelated seed ...
As a SuppVersity reader you are well aware of the interactions between casein micelles and the low and high pH milieu of the intestinal tract. They clump and form a mass that is significantly harder to digest than the easily digestible albumin proteins from whey. But what happens if you ingest them in a complex(er) food matrix? Dutch scientists recently found out...
Albumin is a protein produced by the liver that carries vital nutrients and hormones and circulates them to different organs and tissues of the body. This type of protein is extremely essential to maintain the growth and repair the tissues. If a person has low albumin content and suffers from various symptoms alike- fatigue, unexpected…
Causes of high levels of albumin in urine and the normal range. Urine protein or albumin in urine test may be done using a random sample of your urine as well
Find patient medical information for Albumin on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings.
A new drug, Abraxane, has been developed, and when given with gemcitabine, the FDA approved pancreatic cancer chemo drug, Abraxane extends life about 54 days at a cost of $6,000-8,000 per month. To a pancreatic cancer patient, these 54 days are likely anything but quality days. The proper diet and antifungal drugs can often dramatically increase not only lifespan, but also quality of life. Factoring in a good juicer, some organic vegetables and fruits, the cost of antifungal drugs or great antifungal supplements, and Alpha-glycopeptides to stimulate the bodys immune system to heal itself, within 3 months youll probably spend about $2500! This natural therapy has a 92% "smiling rate" compared to the 54 miserable days laid out by the great pharmaceutical industry. We are getting smarter & we have learned that the barbaric methods are not ...
Access Biologicals offers human-derived proteins in both powder and solution formats.. Powders are soluble, off-white, diagnostic grade of ultra-high purity, fractionated according to Cohn Cold Alcohol techniques from fully traceable, documented plasma from U.S. sources.. Solutions are available in a variety of concentrations suitable for diagnostic or cell culture upgrades and can be custom manufactured to meet your specifications.. All units of plasma used to manufacture Access Biologicals Albumin Powders and solutions were collected exclusively in the U.S., and have been tested and found to be non reactive for HBsAG, Anti-HCV, Anti-HIV-1 and 2.. Performance. 98% Protein with Albumin Purity levels >97%, virtually inactivated, low endotoxin and low protease levels. Ideal choice for sensitive diagnostic assays and applications, extensively tested for a full panel of safety and analytical data. ...
Albumin human, USP, 25% solution is an injectable medication containing the protein albumin in a concentration of 25%. It is obtained from human blood
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Maintenance of blood pressure for tissue perfusion is a cornerstone of sepsis treatment, and albumin plays a significant role in maintaining plasma oncotic
Question - Urinary test done. RBC, pus, ephithelial cells, traces of albumin found. What does it mean?. Ask a Doctor about diagnosis, treatment and medication for Urinary tract infection, Ask a Radiologist
Introduction The majority of deaths from breast cancer are a total result of metastases; nevertheless, small is definitely recognized about the hereditary modifications root their starting point. had been scored by cell keeping track of, circulation cytometry, and scuff and … Continue reading →. ...
Human plasma albumen solutions are prepared from a mixture of blood, plasma, serum or placental tissues obtained from healthy donors. They are then treated by a heat process to inactivate any...
He gave me the option to skip the Abraxane infusion a couple of months back and I opted to go ahead with the chemo. That was when the breast was flaring up again and it scared the heck out of me. But now, the breast looks good. The thought of not having a weekly appointment and infusion was so freeing to even consider, but felt like I was playing hooky. And to think, my hair may start to grow back and provide some winter warmth for me. It is all so hard to even fathom. But I think I could get used to it. We do know that this could only be temporary until we need to find something new to fight these cunning cancer cells trying to take over my body. It is the fight of Metastases, Stage IV Liver Metastasized Breast Cancer. My lifes struggle. ...
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PAB028Hu05, Polyclonal Antibody to Albumin (ALB), 白蛋白(ALB)多克隆抗体, Serum albumin | 仅供体外研究使用,不用于临床诊断!请索取进口关税税单及报关单!
Introduction The majority of deaths from breast cancer are a total result of metastases; nevertheless, small is definitely recognized about the hereditary modifications root their starting point. had been scored by cell keeping track of, circulation cytometry, and scuff and … Continue reading →. ...
Purchase a copy of United States Solvent-based Ink Resin Market Research Report at: http://www.absolutereports.com/purchase/10371290. Further in the United States Solvent-based Ink Resin Market Industry Analysis report, the United States Solvent-based Ink Resin Market is examined for price, cost and gross. These three points are analysed for types, companies and regions. In continuation with this data sale price is for various types, applications and region is also included. The United States Solvent-based Ink Resin Market for major regions is given. Additionally, type wise and application wise consumption figures are also given.. With the help of supply and consumption data, gap between these two is also explained.. Get Discount on United States Solvent-based Ink Resin Market Research Report at: http://www.absolutereports.com/enquiry/request-discount/10371290. To provide information on competitive landscape, this report includes detailed profiles of United States Solvent-based Ink Resin Market ...
Could anybody tell me please what happens to serum albumin on platinum Surfaces. More precisely : How can the unusual adsorption behaviour of serum albumin on platinum, measured by means of ellipsometry, be explained. The time dependence of the amount adsorbed is not reproducible. Thanks a lot ! Trixi Leistner, Joachim Steiner ...
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β-cells release hexameric Zn2+-insulin into the extracellular space, but monomeric Zn2+-free insulin appears to be the only biologically active form. The mechanisms implicated in dissociation of the hexamer remain unclear, but they seem to be Zn2+ concentration-dependent. In this study, we investigate the influence of albumin binding to Zn2+ on Zn2+-insulin dissociation into Zn2+-free insulin and its physiological, methodological and therapeutic relevance. Glucose and K+-induced insulin release were analyzed in isolated mouse islets by static incubation and perifusion experiments in the presence and absence of albumin and Zn2+ chelators. Insulin tolerance tests were performed in rats using different insulin solutions with and without Zn2+ and/or albumin. Albumin-free buffer does not alter quantification by RIA of Zn2+-free insulin but strongly affects RIA measurements of Zn2+-insulin. In contrast, accurate determination of Zn2+-insulin was obtained only when bovine serum albumin or Zn2+ ...
We sought to confirm the prognostic importance of simple clinically available biomarkers of c-reactive protein, serum albumin, and ferritin prior to allogeneic hematopoietic cell transplantation. The study population consisted of 784 adults with acute myeloid leukemia in remission or myelodysplastic syndromes undergoing unrelated donor transplant reported to the Center for International Blood and Marrow Transplant Research. C-reactive protein and ferritin were centrally quantified by ELISA from cryopreserved plasma whereas each center provided pre-transplant albumin. In multivariate analysis, transplant related mortality was associated with the pre-specified thresholds of c-reactive protein , 10 mg/L (P = .008) and albumin , 3.5 g/dL (P = .01) but not ferritin , 2500 ng/mL. Only low albumin independently influenced overall mortality. Optimal thresholds affecting transplant-related mortality were defined as: c-reactive protein , 3.67 mg/L, log(ferritin), and albumin , 3.4 g/dL . A three level ...
0034] Treatment compositions which include serum albumin in accordance with the invention, or the preferable recombinant human serum albumin, can be effectively formulated with a wide variety of conventional ingredients common to lotions, bases, ointments, creams, balms and the like which can comprise the vehicles, excipients or carriers in accordance with the invention, Example of these ingredients include, but are not limited to: Water, Ppg-15 Stearyl Ether, Oxidized Polyethylene, Stearyl Alcohol, Cetyl Betaine, Salicylic Acid, Distearyldimonium Chloride, Sodium Lauryl Sulfate, Cetyl Alcohol, Alcohol, Steareth-21, Cyclopentasiloxane, Niacinamide, Ethylene/Acrylic Acid. Copolymer, Dimethicone Crosspolymer, Propylene Glycol, Butylene Glycol, Panthenol, Peg-10 Dimethicone Crosspolymer, Tocopheryl Acetate Cyclopentasiloxane, Polymethylsilsesquioxane, Stearyl Dimethicone, Palmitoyl Pentapeptide-3, Cetearyl Alcohol, Polysorbate 60, Helianthus annuus (sunflower) seed oil, Butyrospermum parkii (shea ...
Hepatorenal syndrome is a serious complication in patients with liver failure where the patient develops rapidly progressive renal failure that usually results in death. The condition occurs in the context of end-stage liver disease and is often associated with diuretic use for ascites or large-volume paracentesis or spontaneous bacterial peritonitis. ...
UCL Discovery is UCLs open access repository, showcasing and providing access to UCL research outputs from all UCL disciplines.

Intestinal Lymphangiectasia - Mar Vista Animal Medical CenterIntestinal Lymphangiectasia - Mar Vista Animal Medical Center

Low Albumin Level. Low blood albumin level is the most consistent finding in lymphangiectasia, though it is possible to have ... where the albumin is lost via leaking kidney membranes), reduced albumin production by a diseased liver, Hypoadrenocorticisim ( ... Albumin can be considered sort of a mass transit system in the bloodstream, a bus or subway, if you will, carrying important ... Albumin, by being the most prevalent blood protein, also is responsible for actually keeping water in ones bloodstream. When ...
more infohttp://marvistavet.com/intestinal-lymphangiectasia.pml

Bioavailable Vitamin D (1, 25 dihydroxy) |  Pan..."Bioavailable" Vitamin D (1, 25 dihydroxy) | Pan...

Alias Names : Weakly bound Vitamin D 1,25 ; Albumin bound Vitamin D 1, 25 dihydroxy(1,25 di OH) ... Using an affinity constant of 1, 25 dihydroxy D for DBP and albumin, Bioavailable Vitamin D( 1,25 dihydroxy is calculated. ... The free fraction along with the albumin bound fraction, called bioavailable Vitamin D (1, 25 dihydroxy), which is readily ... To obtain the bioavailable fraction, total vitamin D 1,25 dihydroxy, DBP, and albumin were quantitated. ...
more infohttp://panlaboratories.com/bioavailable-vitamin-d-1-25-dihydroxy/

Albumin - WikipediaAlbumin - Wikipedia

Serum albumin[edit]. Main article: Serum albumin. Serum albumin is the most abundant blood plasma protein and is produced in ... For the specific albumins found in vertebrate bloodstreams, see serum albumin. For other uses, see Albumin (disambiguation). ... Serum albumin levels[edit]. The normal range of human serum albumin in adults (, 3 y.o.) is 3.5 to 5 g/dL. For children less ... Wikisource has the text of the 1911 Encyclopædia Britannica article Albumin.. *Albumins at the US National Library of Medicine ...
more infohttps://en.wikipedia.org/wiki/Albumin

Albumin - WikipediaAlbumin - Wikipedia

Serum albumin[edit]. Main article: Serum albumin. Serum albumin is the most abundant blood plasma protein and is produced in ... For the specific albumins found in vertebrate bloodstreams, see serum albumin. For other uses, see Albumin (disambiguation). ... Serum albumin levels[edit]. Normal range of human serum albumin in adults (, 3 y.o.) is 3.5 to 5 g/dL. For children less than ... Wikisource has the text of the 1911 Encyclopædia Britannica article Albumin.. *Albumins at the US National Library of Medicine ...
more infohttps://en.wikipedia.org/wiki/Albumins

Albumin - Undiagnosed Symptoms - MedHelpAlbumin - Undiagnosed Symptoms - MedHelp

I had a test done showing my albumin levels are a little low than normal. Can this be dangerous?? If so in what ... ... Albumin gopo92 Hello. I am 18 years ood and have been suffering from intestinal disease since 10 years. I had a test done ... Albumin is a protein produced by the liver and it forms an important part of the blood as it helps keep the water in the blood ... If your albumin were very low you then you would be increasingly worried that this value was representative of one of the ...
more infohttps://www.medhelp.org/posts/Undiagnosed-Symptoms/Albumin/show/1495525

Albumin  | Definition | AIDSinfoAlbumin | Definition | AIDSinfo

Albumin Albumin Speaker A protein made by the liver and found in the blood. Levels of this protein may be measured as part of a ...
more infohttps://aidsinfo.nih.gov/understanding-hiv-aids/glossary/3365/albumin

Assess Urine Albumin | NIDDKAssess Urine Albumin | NIDDK

A urine albumin-to-creatinine ratio on a spot urine specimen is the recommended test to assess and monitor urine albumin. ... Assess Urine Albumin. For many people, albuminuria is the earliest sign of CKD. A urine albumin-to-creatinine ratio (UACR) on a ... UACR (mg/g)* = Urine Albumin (mg/dL) / Urine Creatinine (g/dL). *UACR (mg/g) is approximately equal to Albumin excretion in mg/ ... Urine albumin is a continuous risk factor. UACR greater than 30 mg/g is considered abnormal. Traditionally, 30-300 mg/g has ...
more infohttps://www.niddk.nih.gov/health-information/communication-programs/nkdep/identify-manage-patients/evaluate-ckd/assess-urine-albumin

albumin (human)albumin (human)

This medicine works by increasing plasma volume or levels of albumin in the blood. Albumin is used to replace blood volume loss ... Medicinal albumin is made of plasma proteins from human blood. ... Albumin is a protein produced by the liver that circulates in ... What is albumin?. Albumin is a protein produced by the liver that circulates in plasma (the clear liquid portion of your blood ... How is albumin given?. Albumin is injected into a vein through an IV. A healthcare provider will give you this injection. ...
more infohttps://www.rexhealth.com/rh/health-library/document-viewer/?id=d02376a1

AlbuminAlbumin

... is made in the liver and is extremely sensitive to liver damage. The concentration of albumin drops when the liver is ... Albumin is the most abundant protein in the blood. It keeps fluid from leaking out of blood vessels; nourishes tissues; and ...
more infohttps://labtestsonline.org.uk/glossary/albumin

Albumin | Define Albumin at Dictionary.comAlbumin | Define Albumin at Dictionary.com

Albumin definition, any of a class of simple, sulfur-containing, water-soluble proteins that coagulate when heated, occurring ... albumin. in Science. albumin. [ăl-byōō′mĭn]. *A class of proteins found in egg white, milk, blood, and various other plant and ... albumin. in Medicine. albumin. (ăl-byōō′mĭn). n.. *A class of simple, water-soluble proteins that can be coagulated by heat and ... albumin. albumen. noun. *any of a group of simple water-soluble proteins that are coagulated by heat and are found in blood ...
more infohttps://www.dictionary.com/browse/albumin

Human Albumin Demo - Drugs.comHuman Albumin Demo - Drugs.com

A list of US medications equivalent to Human Albumin Demo is available on the Drugs.com website. ... Human Albumin Demo is a medicine available in a number of countries worldwide. ... Ingredient matches for Human Albumin Demo. Albumin Human. Albumin Human is reported as an ingredient of Human Albumin Demo in ... Human Albumin Demo. Human Albumin Demo may be available in the countries listed below. ...
more infohttps://www.drugs.com/international/human-albumin-demo.html

Human Albumin Baxalta - Drugs.comHuman Albumin Baxalta - Drugs.com

A list of US medications equivalent to Human Albumin Baxalta is available on the Drugs.com website. ... Human Albumin Baxalta is a medicine available in a number of countries worldwide. ... Ingredient matches for Human Albumin Baxalta. Albumin Human. Albumin Human is reported as an ingredient of Human Albumin ... Human Albumin Baxalta. Human Albumin Baxalta may be available in the countries listed below. ...
more infohttps://www.drugs.com/international/human-albumin-baxalta.html

ALBUMIN 1 (PS00212) | InterPro | EMBL-EBIALBUMIN 1 (PS00212) | InterPro | EMBL-EBI

ALBUMIN_1 (PS00212). Accession PS00212 Integration. Serum albumin, conserved site (IPR020857) Member database. PROSITE patterns ...
more infohttp://www.ebi.ac.uk/interpro/ISignatureOverview?sig=PS00212&query=P

Serum albumin (P02768) | InterPro | EMBL-EBISerum albumin (P02768) | InterPro | EMBL-EBI

InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites. We combine protein signatures from a number of member databases into a single searchable resource, capitalising on their individual strengths to produce a powerful integrated database and diagnostic tool.
more infohttp://www.ebi.ac.uk/interpro/protein/P02768

Recombinant/Transgenic Human Albumins - Albumin | Sigma-AldrichRecombinant/Transgenic Human Albumins - Albumin | Sigma-Aldrich

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View more information on albumin>human serum albumin. ... Sigma-Aldrich has partnered with the technology holders of recombinant human albumin products expressed in Rice, Pichia Product Directory > Biochemicals and Reagents > Proteins and Derivatives > Albumin > Recombinant/Transgenic Human ... Albumin human recombinant, expressed in Pichia pastoris, 5% in aqueous buffer, ≥90% (SDS-PAGE) * pricing ...
more infohttps://www.sigmaaldrich.com/life-science/biochemicals/biochemical-products.html?TablePage=105233201

ALBUMIN PHENOTYPES IN TURKEYS | GeneticsALBUMIN PHENOTYPES IN TURKEYS | Genetics

ALBUMIN PHENOTYPES IN TURKEYS. Indalecio R. Quinteros, R. W. C. Stevens, C. Stormont and V. S. Asmundson ... ALBUMIN PHENOTYPES IN TURKEYS. Indalecio R. Quinteros, R. W. C. Stevens, C. Stormont and V. S. Asmundson ... ALBUMIN PHENOTYPES IN TURKEYS. Indalecio R. Quinteros, R. W. C. Stevens, C. Stormont and V. S. Asmundson ...
more infohttp://www.genetics.org/content/50/4/579

Serum Albumin on PlatinumSerum Albumin on Platinum

... Joachim Steiner steiner at biomed.uni-erlangen.de Thu Jan 29 03:49:16 EST 1998 *Previous message: ... Could anybody tell me please what happens to serum albumin on platinum Surfaces. More precisely : How can the unusual ... adsorption behaviour of serum albumin on platinum, measured by means of ellipsometry, be explained. The time dependence of the ...
more infohttp://www.bio.net/bionet/mm/methods/1998-January/064238.html

ALBUMIN, SERUMALBUMIN, SERUM

ID:1,Note:Reference Interval has been last updated on 22 Apr 2013. ,Date:2013-04-29T10:10:00.000Z,Deleted:false,IsNew:true ...
more infohttps://www.sgh.com.sg/patient-care/specialties-services/albumin-serum-

Role of Albumin | Livestrong.comRole of Albumin | Livestrong.com

Albumin is the most prevalent protein in your blood, and without it, you can experience a number of symptoms. ... The role of albumin in fluid balance and transport means low albumin levels can cause bodily problems that manifest in symptoms ... The albumin in your blood moves the mineral calcium, the hormone progesterone and medicines throughout your tissues. Albumin ... To maintain normal blood albumin ranges, you should have between 3.4 and 5.4 g/dL of albumin in your blood. ...
more infohttps://www.livestrong.com/article/488109-role-of-albumin/

012229: Albumin, Cerebrospinal Fluid | LabCorp012229: Albumin, Cerebrospinal Fluid | LabCorp

Using the results of quantitative CSF and serum albumin assays, a CSF (in mg/dL)/serum (in g/dL) albumin index can be ... Albumin is a particularly suitable indicator of protein because it is neither synthesized nor metabolized intrathecally. In CSF ... The degree of permeability of the blood-brain barrier can be evaluated by the quantitative measurements of albumin in the CSF ... Albumin, Cerebrospinal Fluid. 1746-7. 012230. Albumin, CSF. mg/dL. 1746-7. ...
more infohttps://www.labcorp.com/test-menu/18916/albumin-cerebrospinal-fluid

Albumin Human - Side effect(s)Albumin Human - Side effect(s)

Learn about the known and possible side effects of Albumin Human Not everyone will experience one or all of these side effects ... Albumin Human - Information. Albumin Human is derived from human plasma, used to treat shock as a result of blood loss in the ... Side effect(s) of Albumin Human Read the side effects of Albumin Human as described in the medical literature. In case of any ... Albumin 20% (100ml) , Biseko , Biseko (50ml) , Granocyte , Roferon -A , Sll Human Albumin , Verglob 1000MG , Verglob 2500 , ...
more infohttp://www.medindia.net/drugs/medication-side-effects/albumin_human.htm

Nanoparticle Albumin-Bound Paclitaxel injectionNanoparticle Albumin-Bound Paclitaxel injection

NANOPARTICLE ALBUMIN-BOUND PACLITAXEL (Na no PAHR ti kuhl al BYOO muhn-bound PAK li TAX el) is a chemotherapy drug. ... Nanoparticle Albumin-Bound Paclitaxel injection. What is this medicine?. NANOPARTICLE ALBUMIN-BOUND PACLITAXEL (Na no PAHR ti ... an unusual or allergic reaction to paclitaxel, albumin, other chemotherapy, other medicines, foods, dyes, or preservatives ...
more infohttps://www.nationwidechildrens.org/family-resources-education/family-resources-library/nanoparticle-albumin-bound-paclitaxel-injection

Albumin from hamster | Sigma-AldrichAlbumin from hamster | Sigma-Aldrich

Albumin from hamster for your research needs. Find product specific information including CAS, MSDS, protocols and references. ...
more infohttps://www.sigmaaldrich.com/catalog/product/sial/a5409?lang=en®ion=US

DailyMed - ALBURX (albumin- human solutionDailyMed - ALBURX (albumin- human solution

ALBUMIN HUMAN (UNII: ZIF514RVZR) (ALBUMIN HUMAN - UNII:ZIF514RVZR) ALBUMIN HUMAN. 12.5 g in 50 mL. ... Albumin (Human) 25% Solution AlbuRx® 25 Contains: 12.5 g Albumin (Human) in 50 mL of buffered diluent. Stabilized with 0.02 M ... One vial containing 12.5 grams of albumin. [NDC 44206-251-90]. 100 mL. 44206-251-10. One vial containing 25 grams of albumin. [ ... In all these settings, the circulating albumin mass is initially maintained by a gradual transfer of extravascular albumin to ...
more infohttps://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=ad74b7f5-b380-47ab-b19d-eef92c8eb7a4

Albumin-deficient rat mutant | ScienceAlbumin-deficient rat mutant | Science

Biochemically, the mutant was characterized by an extraordinarily low serum albumin content and a hyperlipidemia. Total serum ... Serum cholesterol was inversely correlated with a decrease in albumin; the correlation coefficient for ablumin was --.92. These ... rats may serve as a model of human familial analbuminemia and may also be useful in elucidating the functional roles of albumin ...
more infohttp://science.sciencemag.org/content/205/4406/590
  • However, the 300 mg/g cut-off merely represents a rough correlation with the lower limit of sensitivity of the traditional urine dipstick for albumin. (nih.gov)
  • Note that the protein "albumin" is spelled with an "i", while "albumen" with an "e", is the white of an egg, which contains (among other things) several dozen types of albumin (with an "i"), mostly ovalbumin. (wikipedia.org)
  • Agricultural engineer, Alicia Fernández San Millán, has developed a novel technique in Spain - plastidial transformation, in order to produce, in a recombinant form, human albumin from tobacco plants. (scienceblog.com)
  • AlbuRx ® 25, Albumin (Human) 25% solution is a sterile aqueous solution for intravenous administration containing the albumin component of human blood. (nih.gov)
  • AlbuRx ® 25, Albumin (Human) 25% solution should not be used as an intravenous nutrient because of the slow breakdown and relatively unfavorable composition of the albumin molecule with respect to its content of essential amino acids. (nih.gov)
  • 16 The two main indications for the use of AlbuRx ® 25, Albumin (Human) 25% solution are therefore a plasma or blood volume deficit and the oncotic deficit resulting from hypoproteinemia. (nih.gov)
  • In the absence of hyperhydration, the treatment of an acute volume deficit with AlbuRx ® 25 should therefore include isotonic electrolyte solutions with an albumin:electrolyte ratio of 1:3 or 1:4. (nih.gov)
  • Dip sticks, similar to common pregnancy tests, have been developed to detect the presence of bear albumin in traditional medicine products, indicating that bear bile had been used in their creation. (wikipedia.org)
  • A urine albumin level that stays the same or goes down may mean that treatments are working. (nih.gov)
  • Competition between drugs for albumin binding sites may cause drug interaction by increasing the free fraction of one of the drugs, thereby affecting potency. (wikipedia.org)
  • You may be able to reduce the amount of albumin in your urine by taking medicines that lower blood pressure called ACE inhibitors or ARBs . (nih.gov)
  • The common causes of hypoproteinemia are protein-calorie malnutrition, defective absorption in gastro-intestinal disorders, faulty albumin synthesis in chronic hepatic failure, increased protein catabolism postoperatively or with sepsis, and abnormal renal losses of albumin with chronic kidney disease. (nih.gov)
  • The doctor is now claiming that one low albumin level on that one particular day indicated I was suffering from malnutrition and that is one of the reasons my surgery failed. (rutgers.edu)
  • The NKDEP Laboratory Working Group , in collaboration with the International Federation of Clinical Chemistry and Laboratory Medicine, has undertaken an effort to standardize the laboratory assessment of urine albumin and the reporting of results to clinicians. (nih.gov)
  • Because you will receive albumin in a clinical setting, you are not likely to miss a dose. (rexhealth.com)
  • The colloid osmotic or oncotic properties of albumin at this moment constitute the predominant reason for its clinical use. (nih.gov)
  • The concentration of albumin drops when the liver is damaged, when a person is malnourished, or if a person experiences inflammation in the body. (labtestsonline.org.uk)
  • Talk with your health care provider about how often you should get a urine test for albumin. (nih.gov)
  • However, one blood test for albumin about 10 days after surgery was a little low (3.0g/dL) but I had been suffering from diarrhea for a week from the cephalosporin antibiotics they were pumping into me and I didn't get any food to eat for approx. (rutgers.edu)
  • Treatment that lowers the urine albumin level may lower the chances that kidney disease will progress to kidney failure. (nih.gov)
  • Is one slightly low albumin level an independent risk factor for adverse results specifically after surgery on ischial ulcers? (rutgers.edu)
  • While the price at the pharmacy of albumin produced using plasma is 4 euros per gram, that obtained from yeasts or mammal cells costs between 300 and 4,000 euros per gram. (scienceblog.com)
  • Another option worked on over recent years has been the production of albumin from vegetables, always using nuclear transformation. (scienceblog.com)
  • A property highly valued by the experts has to be added to these positive results: the production of albumin from plants using this technique does not involve the escape of genes through pollen transmission given that, with most crops under cultivation, the genome of the plastids is inherited maternally. (scienceblog.com)
  • In lab experiments it has been shown that all-trans retinoic acid down regulates human albumin production Other albumin types include the storage protein ovalbumin in egg white, and different storage albumins in the seeds of some plants, including hemp. (wikipedia.org)
  • Albumins dissolve in water and form solid or semisolid masses when heated, such as cooked egg white. (dictionary.com)