Water-soluble proteins found in egg whites, blood, lymph, and other tissues and fluids. They coagulate upon heating.
A major protein in the BLOOD. It is important in maintaining the colloidal osmotic pressure and transporting large organic molecules.
Serum albumin from cows, commonly used in in vitro biological studies. (From Stedman, 25th ed)
Normal human serum albumin mildly iodinated with radioactive iodine (131-I) which has a half-life of 8 days, and emits beta and gamma rays. It is used as a diagnostic aid in blood volume determination. (from Merck Index, 11th ed)
Cell surface proteins that bind albumin with high affinity and trigger intracellular changes influencing the behavior of cells.
A gamma-emitting radionuclide imaging agent used for the diagnosis of diseases in many tissues, particularly in cardiovascular and cerebral circulation.
The presence of albumin in the urine, an indicator of KIDNEY DISEASES.
A condition in which albumin level in blood (SERUM ALBUMIN) is below the normal range. Hypoalbuminemia may be due to decreased hepatic albumin synthesis, increased albumin catabolism, altered albumin distribution, or albumin loss through the urine (ALBUMINURIA).
A major class of water-soluble seed storage proteins. Many proteins from this class are major PLANT ALLERGENS.
Proteins that are present in blood serum, including SERUM ALBUMIN; BLOOD COAGULATION FACTORS; and many other types of proteins.
An indicator and reagent. It has been used in serum albumin determinations and as a pH indicator.
A bile pigment that is a degradation product of HEME.
The property of blood capillary ENDOTHELIUM that allows for the selective exchange of substances between the blood and surrounding tissues and through membranous barriers such as the BLOOD-AIR BARRIER; BLOOD-AQUEOUS BARRIER; BLOOD-BRAIN BARRIER; BLOOD-NERVE BARRIER; BLOOD-RETINAL BARRIER; and BLOOD-TESTIS BARRIER. Small lipid-soluble molecules such as carbon dioxide and oxygen move freely by diffusion. Water and water-soluble molecules cannot pass through the endothelial walls and are dependent on microscopic pores. These pores show narrow areas (TIGHT JUNCTIONS) which may limit large molecule movement.
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.
The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.
The first alpha-globulins to appear in mammalian sera during FETAL DEVELOPMENT and the dominant serum proteins in early embryonic life.
Volume of PLASMA in the circulation. It is usually measured by INDICATOR DILUTION TECHNIQUES.
A process of selective diffusion through a membrane. It is usually used to separate low-molecular-weight solutes which diffuse through the membrane from the colloidal and high-molecular-weight solutes which do not. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Electrophoresis applied to BLOOD PROTEINS.
Any liquid used to replace blood plasma, usually a saline solution, often with serum albumins, dextrans or other preparations. These substances do not enhance the oxygen- carrying capacity of blood, but merely replace the volume. They are also used to treat dehydration.
The presence of proteins in the urine, an indicator of KIDNEY DISEASES.
KIDNEY injuries associated with diabetes mellitus and affecting KIDNEY GLOMERULUS; ARTERIOLES; KIDNEY TUBULES; and the interstitium. Clinical signs include persistent PROTEINURIA, from microalbuminuria progressing to ALBUMINURIA of greater than 300 mg/24 h, leading to reduced GLOMERULAR FILTRATION RATE and END-STAGE RENAL DISEASE.
The rate dynamics in chemical or physical systems.
An indicator and reagent. It has been used for several purposes including the determination of serum albumin concentrations
Elements of limited time intervals, contributing to particular results or situations.
Chemical analysis based on the phenomenon whereby light, passing through a medium with dispersed particles of a different refractive index from that of the medium, is attenuated in intensity by scattering. In turbidimetry, the intensity of light transmitted through the medium, the unscattered light, is measured. In nephelometry, the intensity of the scattered light is measured, usually, but not necessarily, at right angles to the incident light beam.
Therapy for the insufficient cleansing of the BLOOD by the kidneys based on dialysis and including hemodialysis, PERITONEAL DIALYSIS, and HEMODIAFILTRATION.
An iron-binding beta1-globulin that is synthesized in the LIVER and secreted into the blood. It plays a central role in the transport of IRON throughout the circulation. A variety of transferrin isoforms exist in humans, including some that are considered markers for specific disease states.
The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION.
The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
All blood proteins except albumin ( = SERUM ALBUMIN, which is not a globulin) and FIBRINOGEN (which is not in the serum). The serum globulins are subdivided into ALPHA-GLOBULINS; BETA-GLOBULINS; and GAMMA-GLOBULINS on the basis of their electrophoretic mobilities. (From Dorland, 28th ed)
The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH = log 1/2[1/(H+)], where (H+) is the hydrogen ion concentration in gram equivalents per liter of solution. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.
The separation of particles from a suspension by passage through a filter with very fine pores. In ultrafiltration the separation is accomplished by convective transport; in DIALYSIS separation relies instead upon differential diffusion. Ultrafiltration occurs naturally and is a laboratory procedure. Artificial ultrafiltration of the blood is referred to as HEMOFILTRATION or HEMODIAFILTRATION (if combined with HEMODIALYSIS).
A cluster of convoluted capillaries beginning at each nephric tubule in the kidney and held together by connective tissue.
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding.
Two-phase systems in which one is uniformly dispersed in another as particles small enough so they cannot be filtered or will not settle out. The dispersing or continuous phase or medium envelops the particles of the discontinuous phase. All three states of matter can form colloids among each other.
Pathological conditions in the INTESTINES that are characterized by the gastrointestinal loss of serum proteins, including SERUM ALBUMIN; IMMUNOGLOBULINS; and at times LYMPHOCYTES. Severe condition can result in HYPOGAMMAGLOBULINEMIA or LYMPHOPENIA. Protein-losing enteropathies are associated with a number of diseases including INTESTINAL LYMPHANGIECTASIS; WHIPPLE'S DISEASE; and NEOPLASMS of the SMALL INTESTINE.
A condition characterized by severe PROTEINURIA, greater than 3.5 g/day in an average adult. The substantial loss of protein in the urine results in complications such as HYPOPROTEINEMIA; generalized EDEMA; HYPERTENSION; and HYPERLIPIDEMIAS. Diseases associated with nephrotic syndrome generally cause chronic kidney dysfunction.
The lack of sufficient energy or protein to meet the body's metabolic demands, as a result of either an inadequate dietary intake of protein, intake of poor quality dietary protein, increased demands due to disease, or increased nutrient losses.
The adhesion of gases, liquids, or dissolved solids onto a surface. It includes adsorptive phenomena of bacteria and viruses onto surfaces as well. ABSORPTION into the substance may follow but not necessarily.
The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.
Starches that have been chemically modified so that a percentage of OH groups are substituted with 2-hydroxyethyl ether groups.
Plasma glycoprotein clotted by thrombin, composed of a dimer of three non-identical pairs of polypeptide chains (alpha, beta, gamma) held together by disulfide bonds. Fibrinogen clotting is a sol-gel change involving complex molecular arrangements: whereas fibrinogen is cleaved by thrombin to form polypeptides A and B, the proteolytic action of other enzymes yields different fibrinogen degradation products.
State of the body in relation to the consumption and utilization of nutrients.
An amino sugar formed when glucose non-enzymatically reacts with the N-terminal amino group of proteins. The fructose moiety is derived from glucose by the "classical" Amadori rearrangement.
The volume of water filtered out of plasma through glomerular capillary walls into Bowman's capsules per unit of time. It is considered to be equivalent to INULIN clearance.
An LDL-RECEPTOR RELATED PROTEIN found in the neuroepithelium and in proximal tubular cells of the kidney. It is considered a multiligand receptor in that it binds to a variety of ligands with relatively high affinity and may function in mediating the uptake and lysosomal degradation of macromolecules such as: LIPOPROTEINS; ENDOPEPTIDASES; and PROTEASE INHIBITORS.
The parts of a macromolecule that directly participate in its specific combination with another molecule.
Measurement of the intensity and quality of fluorescence.
The movement of materials (including biochemical substances and drugs) through a biological system at the cellular level. The transport can be across cell membranes and epithelial layers. It also can occur within intracellular compartments and extracellular compartments.
Electrophoresis in which a polyacrylamide gel is used as the diffusion medium.
A group of fatty acids that contain 18 carbon atoms and a double bond at the omega 9 carbon.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
The volume of packed RED BLOOD CELLS in a blood specimen. The volume is measured by centrifugation in a tube with graduated markings, or with automated blood cell counters. It is an indicator of erythrocyte status in disease. For example, ANEMIA shows a low value; POLYCYTHEMIA, a high value.
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
A condition in which total serum protein level is below the normal range. Hypoproteinemia can be caused by protein malabsorption in the gastrointestinal tract, EDEMA, or PROTEINURIA.
Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.
A compound formed in the liver from ammonia produced by the deamination of amino acids. It is the principal end product of protein catabolism and constitutes about one half of the total urinary solids.
Classic quantitative assay for detection of antigen-antibody reactions using a radioactively labeled substance (radioligand) either directly or indirectly to measure the binding of the unlabeled substance to a specific antibody or other receptor system. Non-immunogenic substances (e.g., haptens) can be measured if coupled to larger carrier proteins (e.g., bovine gamma-globulin or human serum albumin) capable of inducing antibody formation.
The range or frequency distribution of a measurement in a population (of organisms, organs or things) that has not been selected for the presence of disease or abnormality.
Salts or ions of the theoretical carbonic acid, containing the radical CO2(3-). Carbonates are readily decomposed by acids. The carbonates of the alkali metals are water-soluble; all others are insoluble. (From Grant & Hackh's Chemical Dictionary, 5th ed)
Organic, monobasic acids derived from hydrocarbons by the equivalent of oxidation of a methyl group to an alcohol, aldehyde, and then acid. Fatty acids are saturated and unsaturated (FATTY ACIDS, UNSATURATED). (Grant & Hackh's Chemical Dictionary, 5th ed)
Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.
Treatment process involving the injection of fluid into an organ or tissue.
Products derived from the nonenzymatic reaction of GLUCOSE and PROTEINS in vivo that exhibit a yellow-brown pigmentation and an ability to participate in protein-protein cross-linking. These substances are involved in biological processes relating to protein turnover and it is believed that their excessive accumulation contributes to the chronic complications of DIABETES MELLITUS.
An examination of chemicals in the blood.
An azo dye used in blood volume and cardiac output measurement by the dye dilution method. It is very soluble, strongly bound to plasma albumin, and disappears very slowly.
Unstable isotopes of iodine that decay or disintegrate emitting radiation. I atoms with atomic weights 117-139, except I 127, are radioactive iodine isotopes.
Pathological processes of the KIDNEY or its component tissues.
Fluorescent probe capable of being conjugated to tissue and proteins. It is used as a label in fluorescent antibody staining procedures as well as protein- and amino acid-binding techniques.
The renal tubule portion that extends from the BOWMAN CAPSULE in the KIDNEY CORTEX into the KIDNEY MEDULLA. The proximal tubule consists of a convoluted proximal segment in the cortex, and a distal straight segment descending into the medulla where it forms the U-shaped LOOP OF HENLE.
Stable iodine atoms that have the same atomic number as the element iodine, but differ in atomic weight. I-127 is the only naturally occurring stable iodine isotope.
A technique that combines protein electrophoresis and double immunodiffusion. In this procedure proteins are first separated by gel electrophoresis (usually agarose), then made visible by immunodiffusion of specific antibodies. A distinct elliptical precipitin arc results for each protein detectable by the antisera.
Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).
Dialysis fluid being introduced into and removed from the peritoneal cavity as either a continuous or an intermittent procedure.
Accumulation or retention of free fluid within the peritoneal cavity.
Chemicals and substances that impart color including soluble dyes and insoluble pigments. They are used in INKS; PAINTS; and as INDICATORS AND REAGENTS.
The oxygen-carrying proteins of ERYTHROCYTES. They are found in all vertebrates and some invertebrates. The number of globin subunits in the hemoglobin quaternary structure differs between species. Structures range from monomeric to a variety of multimeric arrangements.
Serum globulins that migrate to the gamma region (most positively charged) upon ELECTROPHORESIS. At one time, gamma-globulins came to be used as a synonym for immunoglobulins since most immunoglobulins are gamma globulins and conversely most gamma globulins are immunoglobulins. But since some immunoglobulins exhibit an alpha or beta electrophoretic mobility, that usage is in decline.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
A procedure in which fluid is withdrawn from a body cavity or organ via a trocar and cannula, needle, or other hollow instrument.
Blood proteins that bind to THYROID HORMONES such as THYROXINE and transport them throughout the circulatory system.
A group of glucose polymers made by certain bacteria. Dextrans are used therapeutically as plasma volume expanders and anticoagulants. They are also commonly used in biological experimentation and in industry for a wide variety of purposes.
A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.
Globulins of milk obtained from the WHEY.
Property of membranes and other structures to permit passage of light, heat, gases, liquids, metabolites, and mineral ions.
Organic compounds that generally contain an amino (-NH2) and a carboxyl (-COOH) group. Twenty alpha-amino acids are the subunits which are polymerized to form proteins.
An imbalanced nutritional status resulted from insufficient intake of nutrients to meet normal physiological requirement.
A technique using antibodies for identifying or quantifying a substance. Usually the substance being studied serves as antigen both in antibody production and in measurement of antibody by the test substance.
An unsaturated fatty acid that is the most widely distributed and abundant fatty acid in nature. It is used commercially in the preparation of oleates and lotions, and as a pharmaceutical solvent. (Stedman, 26th ed)
Proteins in the cerebrospinal fluid, normally albumin and globulin present in the ratio of 8 to 1. Increases in protein levels are of diagnostic value in neurological diseases. (Brain and Bannister's Clinical Neurology, 7th ed, p221)
Experimentally induced tumors of the LIVER.
Serum proteins that have the most rapid migration during ELECTROPHORESIS. This subgroup of globulins is divided into faster and slower alpha(1)- and alpha(2)-globulins.
The interaction of two or more substrates or ligands with the same binding site. The displacement of one by the other is used in quantitative and selective affinity measurements.
Small uniformly-sized spherical particles, of micrometer dimensions, frequently labeled with radioisotopes or various reagents acting as tags or markers.
A non-steroidal anti-inflammatory drug. Oxyphenbutazone eyedrops have been used abroad in the management of postoperative ocular inflammation, superficial eye injuries, and episcleritis. (From AMA, Drug Evaluations Annual, 1994, p2000) It had been used by mouth in rheumatic disorders such as ankylosing spondylitis, osteoarthritis, and rheumatoid arthritis but such use is no longer considered justified owing to the risk of severe hematological adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p27)
The main structural component of the LIVER. They are specialized EPITHELIAL CELLS that are organized into interconnected plates called lobules.
Disorders caused by nutritional imbalance, either overnutrition or undernutrition.

Isolation of rat liver albumin messenger RNA. (1/2483)

Rat liver albumin messenger RNA has been purified to apparent homogeneity by means of polysome immunoprecipitation and poly(U)-Sepharose affinity chromatography. Specific polysomes synthesizing albumin were separated from total liver polysomes through a double antibody technique which allowed isolation of a specific immunoprecipitate. The albumin-polysome immunoprecipitate was dissolved in detergent and the polysomal RNA was separated from protein by sucrose gradient centrifugation. Albumin mRNA was then separated from ribosomal RNA by affinity chromatography through the binding of poly(U)-Sepharose to the polyadenylate 3' terminus of the mRNA. Pure albumin mRNA migrated as an 18 S peak on 85% formamide-containing linear sucrose gradients and as a 22 S peak on 2.5% polyacrylamide gels in sodium dodecyl sulfate. It coded for the translation of authentic liver albumin when added to a heterologous protein-synthesizing cell-free system derived from either rabbit reticulocyte lysates or wheat germ extracts. Translation analysis in reticulocyte lysates indicated that albumin polysomes were purified approximately 9-fold from total liver polysomes, and that albumin mRNA was purified approximately 74-fold from albumin polysomal RNA. The total translation product in the mRNA-dependent wheat germ system, upon addition of the pure mRNA, was identified as authentic albumin by means of gel electrophoresis and tryptic peptide chromatography.  (+info)

Sentinel lymph node biopsy and axillary dissection in breast cancer: results in a large series. (2/2483)

BACKGROUND: Axillary lymph node dissection is an established component of the surgical treatment of breast cancer, and is an important procedure in cancer staging; however, it is associated with unpleasant side effects. We have investigated a radioactive tracer-guided procedure that facilitates identification, removal, and pathologic examination of the sentinel lymph node (i.e., the lymph node first receiving lymphatic fluid from the area of the breast containing the tumor) to predict the status of the axilla and to assess the safety of foregoing axillary dissection if the sentinel lymph node shows no involvement. METHODS: We injected 5-10 MBq of 99mTc-labeled colloidal particles of human albumin peritumorally in 376 consecutive patients with breast cancer who were enrolled at the European Institute of Oncology during the period from March 1996 through March 1998. The sentinel lymph node in each case was visualized by lymphoscintigraphy, and its general location was marked on the overlying skin. During breast surgery, the sentinel lymph node was identified for removal by monitoring the acoustic signal from a hand-held gamma ray-detecting probe. Total axillary dissection was then carried out. The pathologic status of the sentinel lymph node was compared with that of the whole axilla. RESULTS: The sentinel lymph node was identified in 371 (98.7%) of the 376 patients and accurately predicted the state of the axilla in 359 (95.5%) of the patients, with 12 false-negative findings (6.7%; 95% confidence interval = 3.5%-11.4%) among a total of 180 patients with positive axillary lymph nodes. CONCLUSIONS: Sentinel lymph node biopsy using a gamma ray-detecting probe allows staging of the axilla with high accuracy in patients with primary breast cancer. A randomized trial is necessary to determine whether axillary dissection may be avoided in those patients with an uninvolved sentinel lymph node.  (+info)

"The FSGS factor:" enrichment and in vivo effect of activity from focal segmental glomerulosclerosis plasma. (3/2483)

A circulating causative factor has been postulated in focal segmental glomerulosclerosis (FSGS). It has been shown that serum or plasma from some FSGS increases glomerular albumin permeability (Palb) in vitro. Palb greater than 0.5 (i.e., FS activity) is associated with recurrence after transplantation. Specimens from 15 FSGS patients were studied to document the presence of a permeability factor, to isolate this factor, to characterize its biochemical properties, and to show its effect in vivo. Total lipids were extracted by chloroform/methanol (2: 1); FS activity was absent from total lipid extract. Chylomicrons and lipoproteins were removed from the plasma with dextran sulfate, followed by sequential precipitation of proteins at 50 and 70% ammonium sulfate saturation. FS activity was retained in the 70% ammonium sulfate supernatant and exhibited a 100-fold purification. FS activity was lost after heating at 100 degrees C for 10 min or after protease digestion. Under nondenaturing conditions, electrophoresis of the FSGS 70% supernatant showed a prominent low molecular weight band that was not evident in the 70% supernatant from normal plasma. Dialysis and centrifugation-based membrane ultrafiltration of the FSGS factor indicated a molecular size between 30 and 50 kD. Injection of the 70% FSGS supernatant into rats caused a threefold increase in urine protein in collections from 6 to 24 h after injection. No increase in proteinuria occurred in rats injected with 70% supernatant from normal individuals. It is concluded that the FSGS factor is a low molecular weight protein with the potential to increase Palb in vitro and to cause proteinuria in vivo.  (+info)

Triacylglycerol biosynthesis in rat adipose-tissue homogenates. (4/2483)

The optimum cofactor requirements for triacylglycerol biosynthesis in rat adipose-tissue homogenates containing mitochondrial, microsomal and cytosolic fractions were investigated. In general the optimum concentrations of cofactors for triacylglycerol biosynthesis were found to differ from those for total fatty acid esterification. The results provided further evidence for the key role of phosphatidate phosphohydrolase in the regulation of triacylglycerol biosynthesis. Albumin was included in the incubation medium to permit the use of concentrations of added fatty acids that would swamp the effects of endogenous fatty acids. The addition of albumin had little effect on the incorporation of palmitic acid and stearic acid into lipids including triacylglycerols. By contrast, a critical concentration of albumin (about 60 muM) was required before incorporation of oleic acid or linoleic acid into triacylglycerols occurred. The system was used to study the incorporation of different 1-14C-labelled fatty acids from a mixture of unesterified fatty acids [palmitic acid 30%; stearic acid 10%; oleic acid 40%; linoleic acid 20% (molar percentages)] separately into the positions 1,2 and 3 of triacyl-sn-glycerols. In general the stereo-specific distribution of the labelled fatty acids incorporated into triacylglycerols paralleled the normal distribution of fatty acids within rat adipose-tissue triacylglycerols, suggesting that the specificities of the relevant acyltrasferases have the major role in determining the positional distribution of fatty acids within triacylglycerols.  (+info)

von Willebrand factor contained in a high purity FVIII concentrate (Fanhdi) binds to platelet glycoproteins and supports platelet adhesion to subendothelium under flow conditions. (5/2483)

BACKGROUND AND OBJECTIVE: There is evidence suggesting that von Willebrand factor (VWF) from high purity factor VIII concentrates could be of clinical use in the management of patients suffering from VWD. We analyzed structural and functional characteristics of VWF present in a high purity factor VIII concentrate VWFHPC (Fanhdi). The multimeric structure, the ability to bind to platelet GP Ib/IX or GP IIb/IIIa, and the capacity of VWFHPC to promote platelet adhesion on injured vessels were investigated and compared with that present in standard plasma cryoprecipitates [VWFCRYO]. DESIGN AND METHODS: Binding studies were carried out by incubating radiolabeled VWF and washed platelets, which were activated with either ristocetin (1 mg/mL; for GP Ib/IX), or thrombin (2.5 U/mL; for GP IIb/IIIa). Platelet adhesion was assessed in a perfusion system (shear rate = 800 s-1, 10 min) in which the source of VWF was added (at 0.4 or 0.8 U/mL VWF:Ag) to washed platelets and red cells suspended in a human albumin solution. The deposition of platelets onto the perfused subendothelial surface was morphometrically evaluated and expressed as percentage of surface coverage (%SC). RESULTS: The VWFHPC (152 Units VWF:RCof/mg protein; VWF:RCof/VWF:Ag = 0.97), lacked only a small proportion of high-molecular-weight multimers present in VWFCRYO. Binding affinities (Kd values, nM) of VWFHPC were similar to those of VWFCRYO (5.3 +/- 0.86 vs 5.2 +/- 0.95, for GP Ib/IX; and 11.6 +/- 2.7 vs 15.4 +/- 1.7 for GPIIb-IIIa). A slightly, though not significantly, higher binding capacity for these receptors (Bmax values, molecules/pit) was obtained for VWFHPC. The %SC in perfusions in the presence of albumin was < 10%. Addition of VWFHPC or VWFCRYO significantly increased the %SC, with values of 27.1 +/- 4.9 and 17.5 +/- 2.8%, respectively with 0.4 U/mL (p < 0.004 and p < 0.02 vs albumin); and 30.8 +/- 4.9% and 20.03 +/- 4.1%, respectively, at 0.8 U/mL (p < 0.001 and p < 0.02 vs albumin). INTERPRETATION AND CONCLUSIONS: Our data show that VWF present in the high purity FVIII concentrate Fanhdi retains the functional capacity to bind to GPs Ib/IX and IIb/IIIa and to promote platelet adhesion onto exposed subendothelium.  (+info)

Secretory cells of the peripheral pulmonary epithelium as targets for toxic agents. (6/2483)

The extracellular lining of the pulmonary peripheral airways is of vital importance to the lung. In this report, some aspects of the pulmonary extracellular lining and the epithelial cells believed to be responsible for its formation and secretion have been briefly reviewed. The influence of a number of toxic agents on the extracellular lining either directly or via those cells involved in its formation indicates that the extracellular lining may be important in understanding numerous toxic agent interactions with the lung.  (+info)

Peritoneal clearance of leptin in CAPD patients: impact of local insulin administration. (7/2483)

INTRODUCTION: The ob gene product leptin is secreted by fat cells and the serum leptin levels reflects the body fat content. Markedly elevated serum leptin levels have been reported in patients with chronic renal failure. The aim of the present study was to assess if the dialysate leptin levels in peritoneal dialysate are similar to what can be expected from passive diffusion or if intraperitoneal synthesis of leptin may occur. METHODS: We studied 39 patients (20 males), mean age 54+/-12 years, who had been treated with peritoneal dialysis for 17+/-12 months. Ten of the patients were diabetics of which seven used intraperitoneal insulin. A 24-h collection of dialysate was performed and dialysate and fasting blood samples were analysed for leptin, albumin and beta2-microglobulin, and the peritoneal clearances (PCl) were calculated for these solutes. RESULTS: Serum leptin (mean 47+/-76, range 3-350 ng/ml) was related to body mass index (r=0.35, P<0.05). In multiple regression analysis, serum leptin also correlated to serum TNF-alpha. Although dialysate leptin levels correlated to serum leptin, they were higher than expected from the molecular weight of 16 kD. PCl of leptin was 1.3 ml/min (range 0.2-5.9 ml/min), which was 1.6 times higher than expected from the molecular weight of leptin and PCl for albumin and beta2-microglobulin, not taking the protein binding of leptin into account. A strong correlation was found between PCI for albumin and beta2-microglobulin (r = 0.68, P < 0.0001) but neither PCl albumin, nor PCl beta2-microglobulin correlated to PCI leptin. The PCl of leptin was markedly higher in diabetics using intraperitoneal insulin (n = 7) compared to the other 32 patients (2.6+/-2.0 vs 1.1+/-0.7 ml/min, P<0.05). CONCLUSION: Serum leptin is locally produced in the peritoneal cavity, and intraperitoneal insulin enhances local production of leptin.  (+info)

The cytotoxicity of mafosfamide on G-CSF mobilized hematopoietic progenitors is reduced by SH groups of albumin--implications for further purging strategies. (8/2483)

The efficacy of mafosfamide purging depends on factors like incubation time, drug and erythrocyte concentration. To determine the influence of protein-bound SH groups in the incubation medium, the cytotoxicity of mafosfamide on G-CSF mobilized CD34+/- cells was evaluated by short-term culture assays and drug concentration measurements. 100 micromol/ml mafosfamide was incubated for 30 min in five buffers (PBS, PBS with 1%, 5% and 10% BSA and plasma). The mean calculated areas under the concentration-time curves (AUC) were 2489 +/- 198, 1561 +/- 286, 976 +/- 201, 585 +/- 62 and 605 +/- 196 micromol/l/min. The mean reductions of CFU-GM growth were 79.4%, 73.0%, 62.5%, 30.3%, 6.2% respectively. Similar results were obtained for BFU-E. Regression analysis showed a good correlation between cytotoxicity and AUCs (CFU-GM: r = 0.8195; BFU-E: r = 0.8207). This effect is well explained by the different concentrations of SH moieties in the incubation medium resulting in a higher drug binding capacity. The profound difference between AUCs and CFU-GMs in plasma and 10% BSA cannot be explained by the quantity of SH-groups. It is probably due to an additional enzymatic drug degeneration by the 3'-5'exonuclease subsite of plasma DNA polymerase. In conclusion, the concentration of albumin-associated SH groups strongly influences the cytotoxicity of mafosfamide. It has to be considered as a new and important aspect in ex vivo bone marrow purging.  (+info)

Ampullary carcinoma is a rare tumor and evidence on the treatment of recurrent metastatic disease is scarce. We report the case of a 60-year-old patient with an R0-resected node-positive adenocarcinoma of the papilla of Vater of an initially diagnosed intestinal subtype who developed pulmonary metastases 2 months after adjuvant gemcitabine chemotherapy and, subsequently, liver metastases. Palliative combination chemotherapy with standard regimens for intestinal-type adenocarcinoma (FOLFOX and FOLFIRI) failed. However, subsequent combination chemotherapy with nanoparticle albumin-bound paclitaxel and gemcitabine, a regimen with proven efficacy in metastatic adenocarcinoma of the pancreas, resulted in a durable, very good partial remission. Treatment was manageable and well tolerated. Primary tumor and metastatic tissue were reassessed by immunohistochemistry and had to be reclassified to a mixed phenotype containing predominant elements of the pancreatobiliary subtype. Our case suggests that combination
AIM: To assess the impact of guidelines for albumin prescription in an academic hospital, which is a referral center for liver diseases. METHODS: Although randomized trials and guidelines support albumin administration for some complications of cirrhosis, the high cost of albumin greatly limits its use in clinical practice. In 2003, a multidisciplinary panel at SantOrsola-Malpighi University Hospital (Bologna, Italy) used a literature-based consensus method to list all the acute and chronic conditions for which albumin is indicated as first- or second-line treatment. Indications in hepatology included prevention of post-paracentesis circulatory dysfunction and renal failure induced by spontaneous bacterial peritonitis, and treatment of hepatorenal syndrome and refractory ascites. Although still debated, albumin administration in refractory ascites is accepted by the Italian health care system. We analyzed albumin prescription and related costs before and after implementation of the new ...
The purpose of this trial is to determine the benefit of the combination of nab-paclitaxel plus gemcitabine given for 6 cycles, followed by maintenance
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The use of hyperoncotic albumin (HA) for shock resuscitation is controversial given concerns about its cost, effectiveness, and potential for nephrotoxicity. We evaluated the association between early exposure to hyperoncotic albumin (within the first 48 h of onset of shock) and acute organ dysfunction in post-surgical patients with shock. This retrospective, cohort study included 11,512 perioperative patients with shock from 2009 to 2012. Shock was defined as requirement for vasopressors to maintain adequate mean arterial pressure and/or elevated lactate (| 2.2 mmol/L). Subsets of 3600 were selected after propensity score and exact matching on demographics, comorbidities, and treatment variables (| 30). There was a preponderance of cardiac surgery patients. Proportional odds logistic regression, multivariable logistic regression or Cox proportional hazard regression models measured association between hyperoncotic albumin and acute kidney injury (AKI), hepatic injury, ICU days, and mortality.
OBJECT: Human albumin is used to induce hypervolemia (central venous pressure [CVP] , 8 mm Hg) after subarachnoid hemorrhage (SAH). Unfortunately, human albumin may increase the mortality rate in critically ill patients; because of this, its use became restricted in the authors hospital in May 1999. The goal of this study was to determine the effect of human albumin on outcome and cost in patients with SAH before and after this restriction was put into place. METHODS: All patients with aneurysmal SAH who were admitted to the authors institution between May 1998 and May 2000 were studied. Basic demographic information, dosage of human albumin given, length of stay, and the incidence of in-hospital deaths and complications were collected. The authors obtained Glasgow Outcome Scale (GOS) scores at 3 months after SAH (good outcome, GOS , or = 4). Data were analyzed using t-test and chi-square analysis. Logistic regression was used to identify independent associations between use of human albumin ...
5438 Background: Docetaxel (Taxotere) is currently formulated in the surfactant Tween 80. Removal of surfactants from taxane formulations e.g., in the case of nanoparticle albumin-bound paclitaxel (Abraxane) resulted in significantly higher response rates and greater safety (Gradishar, JCO, 2005, 23:7794). Tween 80 strongly inhibited the binding of taxanes to albumin, possibly inhibiting albumin based drug transport via the gp60 endothelial receptor (Desai, EORTC-NCI-AACR, 2004) and consequent reduction of albumin-binding to tumor secreted SPARC. Herein, we compared the efficacy, toxicity, and pharmacokinetics (PK) of nab-docetaxel vs Taxotere. Methods: Nanoparticle nab-docetaxel was prepared using nab technology and characterized. Nab-docetaxel and Taxotere were tested in vivo against HCT-116 human colon carcinoma xenograft in nude mice (n=10/group) at equitoxic doses of 22 mg/kg of nab-docetaxel and 15 mg/kg of Taxotere, on a q4dx3 schedule. Single dose toxicity (TOX) of nab-docetaxel was ...
article{8d460a00-2713-4df9-af4f-6169013fd070, author = {Bakoush, Omran and Tencer, Jan and Torffvit, Ole and Tenstad, Olav and Skogvall, Ingela and Rippe, Bengt}, issn = {1460-2385}, language = {eng}, number = {7}, pages = {1724--1731}, publisher = {Oxford University Press}, series = {Nephrology Dialysis Transplantation}, title = {Increased glomerular albumin permeability in old spontaneously hypertensive rats.}, url = {http://dx.doi.org/10.1093/ndt/gfh276}, volume = {19}, year = {2004 ...
Preclinical studies have recently shown that albumin has neuroprotective effects for stroke in animal models. Thus, we sought to evaluate the effects of albumin therapy in patients with acute cerebral infarcts. We prospectively studied 49 patients with moderate-to-severe cerebral infarcts within the middle cerebral arterial territory into one of two groups: the control group (N = 18) received saline, whereas the albumin group (N = 31) received either 40 g or 80 g of albumin within 24 h from symptom onset.. The modified National Institutes of Health Stroke Scale (mNIHSS) and diffusion-weighted imaging (DWI) were serially checked. There was no adverse effect related to albumin therapy. Although there was no significant difference in both baseline mNIHSS score and DWI lesion volume on admission, the mNIHSS scores at the 14(th) day after treatment and the increase in DWI lesion volume 72-96 h after treatment were significantly reduced in patients of the albumin group (p = 0.001 and 0.012, ...
Gonzalez-Villasana V, Rodriguez-Aguayo C, Arumugam T, Cruz-Monserrate Z, Fuentes-Mattei E, Deng D, Hwang RF, Wang H, Ivan C, Garza RJ, Cohen E, Gao H, Armaiz-Pena GN, Del C Monroig-Bosque P, Philip B, Rashed MH, Aslan B, Erdogan MA, Gutierrez-Puente Y, Ozpolat B, Reuben JM, Sood AK, Logsdon C, Lopez-Berestein G. Bisphosphonates inhibit stellate cell activity and enhance antitumor effects of nanoparticle albumin-bound paclitaxel in pancreatic ductal adenocarcinoma. . 2014 Nov; 13(11):2583-94 ...
[126 Pages Report] Check for Discount on Global Albumin-based Sealants Sales Market Report 2016 report by QYResearch Group. Notes: Sales, means the sales volume of Albumin-based Sealants...
Purpose: Circulating Tumor cells (CTC) are prognostic in metastatic breast cancer (MBC). We tested whether EpCAM based capture system (CellSearch®) is effective in patients with triple negative (TN) MBC, and whether CTC-apoptosis and clustering enhances the prognostic role of CTC. Experimental Design: CTC enumeration and apoptosis was determined using the CXC CellSearch® kit at baseline and days 15 and 29 in blood drawn from TN MBC patients who participated in a prospective randomized phase II trial of nanoparticle albumin-bound paclitaxel (nab-PAC) with or without tigatuzumab (TIG). Association between levels of CTC and patient outcomes was assessed using logistic regression, Kaplan Meier curves, and Cox proportional hazards modeling. Results: Nineteen of 52 (36.5%), 14/52 (26.9%), and 13/49 (26.5%) patients who were evaluable had elevated CTC (≥5CTC/7.5 ml WB) at baseline, days 15 and 29, respectively. Patients with elevated vs. not elevated CTC at each time point had worse progression ...
Ampullary carcinoma is a rare tumor and evidence on the treatment of recurrent metastatic disease is scarce. We report the case of a 60-year-old patient with an R0-resected node-positive adenocarcinoma of the papilla of Vater of an initially diagnosed intestinal subtype who developed pulmonary metastases 2 months after adjuvant gemcitabine chemotherapy and, subsequently, liver metastases. Palliative combination chemotherapy with standard regimens for intestinal-type adenocarcinoma (FOLFOX and FOLFIRI) failed. However, subsequent combination chemotherapy with nanoparticle albumin-bound paclitaxel and gemcitabine, a regimen with proven efficacy in metastatic adenocarcinoma of the pancreas, resulted in a durable, very good partial remission. Treatment was manageable and well tolerated. Primary tumor and metastatic tissue were reassessed by immunohistochemistry and had to be reclassified to a mixed phenotype containing predominant elements of the pancreatobiliary subtype. Our case suggests that ...
this section was added after the table:. Description of selected adverse reactions Blood and lymphatic system disorders. Neutropenia was the most notable important haematological toxicity (reported in 79% of patients), and was rapidly reversible and dose dependent; leukopenia was reported in 71% of patients. Grade 4 neutropenia (, 0.5 x 109/l) occurred in 9% of patients treated with Abraxane. Febrile neutropenia occurred in four patients on Abraxane. Anaemia (Hb , 10 g/dl) was observed in 46% of patients on Abraxane, and was severe (Hb , 8 g/dl) in three cases. Lymphopenia was observed in 45% of the patients.. Nervous system disorders In general, the frequency and severity of neurotoxicity was dose‑dependent in patients receiving Abraxane. Peripheral neuropathy (mostly Grade 1 or 2 sensory neuropathy) was observed in 68% of patients on Abraxane with 10% being Grade 3, and no cases of Grade 4.. Gastrointestinal disorders Nausea occurred in 29% of the patients and diarrhoea in 25% of the ...
Pancreatic cancer is a hypoperfused tumor, characterized by a high stroma density precluding cytotoxics delivery to the epithelial tumoral compartment. There is thus a rationale for combining chemotherapy and antistromal drugs like nab-paclitaxel (Abraxane), a solvent (Cremophor® EL)-free, albumin-bound form of paclitaxel that has been initially developed to reduce the toxicities associated with Taxol injection while maintaining or improving its chemotherapeutic effect. This unique protein formulation provides a novel approach of increasing intra-tumoral concentrations of the drug by a receptor-mediated transport process allowing transcytosis across the endothelial cell.. Abraxane has been approved for commercialization in 38 countries, including the US, Canada, the EU, Australia, China, India and Korea for the treatment of women with metastatic breast cancer. Abraxane alone and in combination is being evaluated in a number of cancers, including metastatic melanoma, non-small cell lung cancer, ...
Biocon Limited, Indias pioneering biotechnology company, and Abraxis BioScience, Inc. (NASDAQ:ABII), a fully integrated biotechnology company, today announced the launch of ABRAXANE(R) (paclitaxel protein-bound particles for injectable suspension) (albumin-bound) in India for the treatment of breast cancer after failure of combination therapy for metastatic disease or relapse within six months of adjuvant chemotherapy. ABRAXANE is now available in India as a single-use 100 mg vial (as a lyophilized powder, to be reconstituted for intravenous administration). In October 2007, ABRAXANE was approved by the Drug Controller General of India. The approval was based on the clinical trial data that was the basis of approval in the United States. The Phase III clinical trial in the U.S. demonstrated that ABRAXANE nearly doubled the response rate, significantly prolonged time to progression, and significantly improved overall survival in the second-line setting versus solvent-based Taxol(R) in the ...
Introduction- Exercise-induced plasma volume (PV) expansion is typically associated with an increase in plasma albumin content. Increased hepatic albumin synthesis, a transcriptionally regulated process, is thought to contribute to the increase in albumin content. Objective- We tested the hypothesis that exercise training induces an increase in albumin gene expression in relationship to the increase in PV. Methods and Results- 40 adult male Sprague-Dawley rats weighing between 245-350 grams were randomly assigned to one of four groups: cage control (CC); sham exercise 10 min/day at 48% VO2max (NE); continuous exercise training, 60 min /day at 72% VO2max (LI); and high intensity, intermittent exercise training, 8 bouts of 4 min at 98% VO2max followed by 5 min at 48% VO2max (HI). The training period lasted for two weeks with 12 training sessions with equalized training volumes in the exercise groups. 24 hours after the last training session the rats were anesthetized and a jugular catheter was placed for
Decreased albumin synthesis by hepatocytes in liver injury is thought to occur in response to Kupffer cell-derived acute-phase cytokines. In this study we used hepatocytes maintained in a differentiated phenotype, by culture on a laminin-rich gel substratum (Engelbreth-Holm-Swarm matrix), to investigate the effects of Kupffer cell-conditioned medium and purified cytokines (interleukin-1, interleukin-6 and tumor necrosis factor-a) on albumin synthesis. Kupffer cell-conditioned medium caused a reversible decrease in albumin synthesis to 64.7% of control (p , 0.01, Wilcoxons rank sum test, n = 11) on day 2. Repeated doses caused further dose-dependent reversible responses. The same result was obtained when protease inhibitors (α1-antitrypsin and α2-macroglobulin) were added to Kupffer cell-conditioned medium (n = 3), thus eliminating the potential effect of matrix degradation. Pure interleukin-1, interleukin-6 and tumor necrosis factor-α also inhibited albumin synthesis (p , 0.05, Wilcoxons ...
The phase III clinical trials in the US and China on which this approval was based demonstrated that Abraxane doubled the response rate, significantly prolonged time to tumour progression, and in the US trial, significantly improved overall survival versus Taxol in the approved indication.. Data from the US pivotal head-to-head trial demonstrated that Abraxane nearly doubled the overall response rate versus Taxol (33% vs. 19%; P = .001) and achieved a 25% percent improvement in time to tumour progression when compared to Taxol. Furthermore, patients receiving Abraxane in the second-line setting had a significantly prolonged survival by an additional 27% compared to solvent-based Taxol. The tolerability with Abraxane and Taxol was comparable, despite the 50% greater dose of paclitaxel administered as Abraxane.. A second head-to-head trial in Chinese patients with metastatic breast cancer further demonstrated the improved efficacy of Abraxane compared to solvent-based Paclitaxel Injection. ...
Next article in issue: Detection of albumin messenger RNA in blood is not restricted to hepatocellular carcinoma Next article in issue: Detection of albumin messenger RNA in blood is not restricted to hepatocellular carcinoma ...
Albumin has a long serum half-life due to its unique ability to bind the cellular neonatal Fc receptor (FcRn), which provides protection from intracellular degradation. The interaction can be capitalized to improve the efficacy of drugs by extending their serum persistence. However, species-specific binding of albumin to FcRn challenges preclinical development. The goal of this brief review is to provide insights into how FcRn and cross-species binding differences affect the pharmacokinetics of human serum albumin (HSA) in different animal models, and gives an overview of genetically modified mice that may serve as improved models for testing of albumin-based drugs. Curr Opin Chem Eng 2018 Mar; 19:68-76.
Although a critical role for caveolae-mediated albumin transcytosis in pulmonary endothelium is well established, considerably less is known about caveolae-independent pathways. In this current study, we confirmed that cultured rat pulmonary microvascular (RPMEC) and pulmonary artery (RPAEC) endothelium endocytosed Alexa488-labeled albumin in a saturable, temperature-sensitive mode and internalization resulted in co-localization by fluorescence microscopy with cholera B toxin and caveolin-1. Although siRNA to caveolin-1 (cav-1) in RPAEC significantly inhibited albumin uptake, a remnant portion of albumin uptake was cav-1-independent, suggesting alternative pathways for albumin uptake. Thus, we isolated and cultured mouse lung endothelial cells (MLEC) from wild type and cav-1-/- mice and noted that ∼ 65% of albumin uptake, as determined by confocal imaging or live cell total internal reflectance fluorescence microscopy (TIRF), persisted in total absence of cav-1. Uptake of colloidal gold ...
Abraxane® (nab-paclitaxel) prolonged life in patients with metastatic pancreatic cancer by an average of two months longer than chemotherapy and significantly increased the percentage of patients who survived for up to two years, according to the results of a study presented at the 2013 Gastrointestinal Cancers Symposium in San Francisco.. Pancreatic cancer is one of the deadliest forms of cancer. Each year, approximately 43,000 people are diagnosed with pancreatic cancer in the United States and close to 37,000 die from the disease. The disease is often diagnosed at an advanced stage, and treatment of advanced disease remains challenging.. Gemzar® (gemcitabine) has been a standard chemotherapy drug for the treatment of advanced pancreatic cancer for some time. Abraxane is a novel form of the widely used cancer drug Taxol (paclitaxel). In Abraxane, the paclitaxel is bound to albumin, a human protein in tiny particles. This formulation improves the delivery of the drug directly to cancer cells ...
The curative effects of nanoparticle albumin-bound (nab)-paclitaxel in the first-line treatment of metastatic breast cancer (MBC) are still controversial, with even more after the removal of marketing approval of indication of bevacizumab. Five electronic databases and the related resources were searched for eligible randomized clinical trials (RCTs) without year and language restrictions to perform a meta-analysis. The studies were comparing the efficacy and safety between nab-paclitaxel chemotherapy versus solvent-based (sb)-taxanes chemotherapy such as sb-paclitaxel and docetaxel. The primary end points were overall response rate (ORR) and disease control rate (DCR). Secondary end points were progression-free survival (PFS), overall survival (OS), adverse events (AEs), and dose discontinuation rate (DDR). Five RCTs (1,554 patients) were finally identified from 1,902 studies. When compared to sb-paclitaxel, nab-paclitaxel showed significant beneficial effects in terms of ORR (OR 2.39, 95% CI ...
Rabbit plasma albumin was labelled with I131, injected intravenously, and measurements were made of the radioactivity in plasma, urine, and feces over many days. In some experiments plasma radioactivity was fractionated into I131-albumin activity and that of labelled breakdown products. Curves of these radioactivities were compared with corresponding curves predicted by four mathematical models. Each model included a vascular and extravascular albumin compartment in transfer equilibrium, a radioactive breakdown products compartment, and an excretion compartment; but model A supposed I131-albumin catabolism to occur within the vascular system, model B within the extravascular compartment, model C within both, and model D within a separate compartment receiving albumin for catabolism from the plasma. The experimental data were reasonably well predicted by models A and C. However, model D, though data were insufficient for its complete validation, gave the best predictions and agrees with present ...
TY - JOUR. T1 - Treatment Rationale and Design for J-AXEL. T2 - A Randomized Phase 3 Study Comparing Nab-Paclitaxel With Docetaxel in Patients With Previously Treated Advanced Non-Small-Cell Lung Cancer. AU - Yoneshima, Yasuto. AU - Morita, Satoshi. AU - Ando, Masahiko. AU - Miura, Satoru. AU - Yoshioka, Hiroshige. AU - Abe, Tetsuya. AU - Kato, Terufumi. AU - Kondo, Masashi. AU - Hosomi, Yukio. AU - Hotta, Katsuyuki. AU - Yamamoto, Nobuyuki. AU - Kishimoto, Junji. AU - Nakanishi, Yoichi. AU - Okamoto, Isamu. PY - 2017/1/1. Y1 - 2017/1/1. N2 - Background Nanoparticle albumin-bound (nab) paclitaxel is a promising new therapeutic agent for all histologic types of non-small-cell lung cancer (NSCLC). We recently performed a phase 2 study of weekly nab-paclitaxel in patients with previously treated advanced NSCLC, finding promising activity and acceptable toxicity for this regimen. We have now designed a randomized phase 3 intergroup study (J-AXEL, UMIN000017487) to examine the clinical benefit and ...
The review by Wilkes and Navickis is the 13th meta-analysis evaluating the effect of fluids on mortality in seriously ill patients. The strengths of this meta-analysis are the comprehensive search strategies used to identify primary studies, which minimised publication and English language bias; the explicit selection criteria used; the use of methodological quality, such as random assignment, as an inclusion criterion; extraction of data in duplicate; and rating of treatment allocation, crossovers, and blinding for each included study. However, all relevant co-interventions, such as blood products, were not well reported in the original trials. 23 of 78 potentially eligible studies were excluded because no mortality data were available, highlighting how many trials were designed to address short term physiological endpoints.. In this meta-analysis, the relative risk (RR) of mortality for all patients was 1.11 (table⇑). Subgroup analyses were planned a priori, and included surgery or trauma ...
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Roche (SIX: RO, ROG; OTCQX: RHHBY) today announced that the European Medicines Agencys (EMA) Committee for Medicinal Products for Human Use (CHMP) has adopted a positive opinion for Tecentriq® (atezolizumab) in combination with chemotherapy (carboplatin and Abraxane® [albumin-bound paclitaxel; nab-paclitaxel]), for the initial (first-line) treatment of adults with metastatic non-squamous non-small cell lung cancer (NSCLC) who do not have EGFR mutant or ALK-positive NSCLC. This decision is based on results from the Phase III IMpower130 study, which demonstrated that the Tecentriq combination therapy helped people live significantly longer, compared with chemotherapy alone (median overall survival [OS]=18.6 versus 13.9 months; hazard ratio [HR]=0.79; 95% CI: 0.64-0.98; p=0.033) in the intention-to-treat (ITT) population.1 The Tecentriq-based combination also significantly reduced the risk of disease worsening or death (progression-free survival, PFS) compared with chemotherapy alone (median ...
SOUTH SAN FRANCISCO, Calif.-(BUSINESS WIRE)-Genentech, a member of the Roche Group (SIX: RO, ROG; OTCQX: RHHBY), today announced positive results from the Phase III IMpassion130 study of Tecentriq® (atezolizumab) plus chemotherapy (Abraxane® [albumin-bound paclitaxel; nab-paclitaxel]) for the initial (first-line) treatment of unresectable locally advanced or metastatic triple-negative breast cancer (TNBC). The Tecentriq and chemotherapy combination significantly reduced the risk of disease worsening or death (progression-free survival; PFS) compared with chemotherapy alone in all randomized patients (intention-to-treat [ITT]) (median PFS=7.2 vs. 5.5 months; hazard ratio [HR]=0.80, 95% CI: 0.69-0.92, p=0.0025) and the PD-L1-positive population (median PFS=7.5 vs. 5.0 months; HR=0.62, 95% CI: 0.49-0.78, p,0.0001), a subgroup determined by PD-L1 biomarker testing. At this interim analysis, statistical significance was not met for overall survival (OS) in the ITT population (median OS=21.3 vs. ...
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Although gemcitabine exhibits potent cytotoxicity against PDA cells in vitro, its short half-life may contribute to its relatively weak antitumor activity in vivo. Indeed, methods that increase gemcitabine delivery (3) or stability (22) have been proposed to circumvent this problem clinically. Taxanes are also active in pancreatic cancer xenografts and patients, although treatment is limited by systemic toxicity (23, 24). nab-Paclitaxel is a solvent-free formulation composed of paclitaxel and human albumin with a mean particle size of 130 nm. It offers several advantages over solvent-based paclitaxel, including increased water solubility that obviates Cremophor EL-based toxicities. In addition, albumin is hypothesized to target paclitaxel to stromal-rich tumors and thereby increase the local concentration. Although combinations of gemcitabine and taxanes have demonstrated antitumor activity in patients with PDA, its toxicity has limited its use in the clinic (25). Accumulating clinical data ...
The Therapeutic Goods Administration (TGA) has taken steps today to quarantine CSL Human Albumin solutions from further use while an asse
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Relationship between ischemia/reperfusion-induced albumin clearance across the mucosa of the small intestine and the reduction in oxygen consumption induced during the ischemic period. Used with permission from Gastroenterology 1985; 89: pp. 852-857.
The anatomy of PFO suggests that it can allow thrombi and potentially harmful circulatory factors to travel directly from the venous to the arterial circulation - altering circulatory phenotype. Our previous publication using high-resolution LC-MS/MS to profile protein and peptide expression patterns in plasma showed that albumin was relatively increased in donor samples from PFO-related than other types of ischemic strokes. Since albumin binds a host of molecules and acts as a carrier for lipoproteins, small molecules and drugs, we decided to investigate the albumin-bound proteins (in a similar sample cohort) in an effort to unravel biological changes and potentially discover biomarkers related to PFO-related stroke and PFO endovascular closure. The method used in this study combined albumin immuno-enrichment with high resolution LC-MS in order to specifically capture and quantify the albumin-bound proteins. Subsequently, we measured cholesterol and HDL in a larger, separate cohort of PFO stroke
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TY - JOUR. T1 - Macromolecule uptake into the cultured endothelial cells and the cell morphology in separated flow. AU - Kudo, Susumu. AU - Sato, Masashi. AU - Machida, Kazutoshi. AU - Yamaguchi, Ryuhei. AU - Kurokawa, Motoyoshi. AU - Matsuzawa, Teruo. AU - Ikeda, Mariko. AU - Oka, Kotaro. AU - Tanishita, Kazuo. PY - 1999/11. Y1 - 1999/11. N2 - One purpose of this study is to investigate the morphological change of endothelial cells in a separated flow area. The other is to reveal the albumin uptake into endothelial cells, the albumin uptake area, and the its content per unit area in the separated flow area. After 24 hr of exposure to flow induced in a back step flow channel, the endothelial cells were incubated in 37°C for 60 minutes in PBS containing tetramethylrhodamine isothiocyanate conjugated albumin (TRITC-albumin). Thereafter, the cell morphology, the density, and the albumin uptake were observed by a confocal laser scanning microscope (CLSM). In low shear stress areas (stagnant and ...
Albumin synthesis was measured in the isolated perfused rat liver by using the livers of both well-fed and starved rats. Starvation markedly decreased albumin synthesis. The livers from starved rats were unable to increase synthesis rates after the addition to the perfusates of single amino acids or the addition of both glucagon and tryptophan. Arginine, asparagine, isoleucine, leucine, lysine, methionine, phenylalanine, proline, threonine, tryptophan and valine, added together to ten times their normal peripheral blood concentrations, restored synthesis rates to normal. The plasma aminogram (i.e. the relative concentrations, of amino acids) was altered by depriving rats of protein for 48h. The use of blood from the deprived rats as perfusate, instead of normal blood, decreased albumin synthesis rates significantly by livers obtained from well-fed rats. The addition of single amino acids, including the non-metabolizable amino acid, α-aminoisobutyric acid, to the above mixture increased albumin ...
Albumin is the most abundant plasma protein. Critical illness is often associated with altered, predominately decreased, serum albumin levels. This hypoalbuminaemia is usually corrected by administration of exogenous albumin. This study aimed to track the concentration-dependent influence of albumin on blood coagulation in vitro. Whole blood (WB) samples from 25 volunteers were prepared to contain low (19.3 ± 7.7 g/L), physiological (45.2 ± 7.8 g/L), and high (67.5 ± 18.1 g/L) levels of albumin. Haemostatic profiling was performed using a platelet function analyzer (PFA) 200, impedance aggregometry, a Cone and Platelet analyzer (CPA), calibrated automated thrombogram, and thrombelastometry (TEM). Platelet aggregation-associated ATP release was assessed via HPLC analysis. In the low albumin group, when compared to the physiological albumin group, we found: i) shortened PFA 200-derived closure times indicating increased primary haemostasis; ii) increased impedance aggregometry-derived amplitudes,
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TY - GEN. T1 - Effect of pulsatile flow on the Albumin permeability across the endothelial cell layer. AU - Kawarabayashi, Minoru. AU - Ikeda, Mariko. AU - Tanishita, Kazuo. PY - 2001. Y1 - 2001. N2 - The effect of pulsatile flow on the albumin permeability across the endothelial cell layer was discussed. The morphology and functions of the cells were affected by the external mechanical stimulus. It was found that the pulsation promoted the different mechano-transduction process from that of the steady flow.. AB - The effect of pulsatile flow on the albumin permeability across the endothelial cell layer was discussed. The morphology and functions of the cells were affected by the external mechanical stimulus. It was found that the pulsation promoted the different mechano-transduction process from that of the steady flow.. UR - http://www.scopus.com/inward/record.url?scp=0242693884&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0242693884&partnerID=8YFLogxK. M3 - Conference ...
To avoid the potentially devastating consequences of the complications of cirrhosis, a better understanding of the effectiveness of available prevention and treatment strategies would be useful. While the use of albumin in the management of cirrhosis complications is currently recommended and widely employed, the effectiveness of albumin to prevent specific disease complications is less clear. Previous reviews have evaluated the effects of albumin therapy both in cirrhotic patients with infections (SBP and non-SBP)4 5 and in patients with cirrhosis-related ascites undergoing paracentesis.6 7 The reviews of albumin use in patients with infections,4 5 however, were written more than 5 years ago and new studies may have been conducted since. The most recent reviews in albumin use in paracentesis, published in 20127 and 2017,6 on the other hand, have come to contradictory conclusions on the albumins effectiveness to prevent of death after the procedure. None of the reviews included SBP as a study ...
Albumin was isolated from pooled fetal serum from 58 placentas obtained at normal delivery at term and from pooled adult plasma from 8 individuals. Albumin isolation was carried out by means of PEG precipitation followed by ion-exchange chromatography on DEAE-Sephadex A 50 and then on SP-Sephadex C 50. The electrophoresis on SDS-polyacrylamide gels showed only one spot that comigrated with commercial human albumin. Binding to albumin was measured by equilibrium dialysis of an aliquot of albumin solution (0.7 ml) against the same volume of 0.13 M sodium orthophosphate buffer (pH 7.4). At a total concentration of 2-mu-g/ml (therapeutic range), the unbound fraction of furosemide was 2.71% (fetal albumin) and 2.51% (adult albumin). Two classes of binding sites for furosemide were observed in fetal and adult albumin. The number of binding sites (moles of furosemide per mole of albumin) was 1.22 (fetal albumin) and 1.58 (adult albumin) for the high-affinity site and 2.97 (fetal albumin) and 3.25 ...
Basel, 17. Januar 2019. Roche (SIX: RO, ROG; OTCQX: RHHBY) today announced that the US Food and Drug Administration (FDA) has accepted the companys supplemental Biologics License Application (sBLA) for Tecentriq® (atezolizumab) in combination with Abraxane® [albumin-bound paclitaxel; nab-paclitaxel]) and carboplatin for the initial (first-line) treatment of people with metastatic non-squamous non-small cell lung cancer (NSCLC) who do not have EGFR or ALK genomic tumour aberrations. The FDA is expected to make a decision on approval by 2 September 2019.. We look forward to working with the FDA in order to bring this Tecentriq-based combination to people with non-squamous non-small cell lung cancer as soon as possible, said Sandra Horning, MD, Roches Chief Medical Officer and Head of Global Product Development. Lung cancer is a challenging disease to treat, and this review takes us one step closer towards offering a new treatment option that has shown a clinically meaningful survival ...
Albumin is the primary component of plasma proteins and accounts for 80% of colloid osmotic pressure. Its three domains determine the binding properties for several endogenous molecules and drugs. The cystein -SH residue accounts for its antioxidant properties and binding of nitric oxide, modulating its effect. The imidazole residues of 16 istidine molecules make albumin the most powerful buffer in the extravascular space. Plasma albumin concentration is a powerful dose-dependent predictor of mortality. Three relevant subsequent metanalysis, in sequence, found albumin administration harmful, neutral and advantageous. The blind, controlled and randomized SAFE study, performed in a large Intensive Care population, found similar outcomes in patient treated with 4% albumin or crystalloids for fluid resuscitation. The subgroup analysis showed a beneficial trend in septic patients treated with albumin and unfavourable trend in trauma patients with brain injury. Unfortunately albumin has been mainly ...
Albumins are a group of acidic proteins which occur plentifully in the body fluids and tissues of mammals and in some plant seeds. Unlike globulins, albumins have comparatively low molecular weights, are soluble in water, are easily crystallized, and contain an excess of acidic amino acids. Serum and plasma albumin is carbohydrate-free and comprises 55-62% of the protein present.. Albumin binds water, Ca2+, Na+, and K+. Due to a hydrophobic cleft, albumin binds fatty acids, bilirubin, hormones, and drugs. The main biological function of albumin is to regulate the colloidal osmotic pressure of blood. Human and bovine albumins contain 16% nitrogen and are often used as standards in protein calibration studies. Albumin is used to solubilize lipids, and is also used as a blocking agent in Western blots or ELISA applications. Globulin free albumins are suitable for use in applications where no other proteins should be present (e.g., electrophoresis).. ...
Healthy volunteers in the postabsorptive state (n = 10), patients with acute inflammatory abdominal disease and plasma C-reactive protein over 100 mg/L (n = 10), and patients scheduled for elective pancreatic resection at the beginning of surgical procedure (n = 10) were studied. The albumin synthesis rate was measured by the flooding dose technique comprising the incorporation of deuterium-labeled phenylalanine in de novo synthesized albumin determined by a gas chromatography mass spectrometer.[1] Total albumin pool was determined by measuring plasma volume using 125I-albumin and plasma albumin concentrations. The 3 groups were compared by means of one-way analysis of variance. ...
TY - JOUR. T1 - The organ targetability of small and large albumin microspheres containing free and HSA conjugated methotrexate. AU - Kim, Chong Kook. AU - Hwang, Sung Joo. AU - Lee, Myung Gull. PY - 1993/1/15. Y1 - 1993/1/15. N2 - The organ-targeting ability of [3H]methotrexate ([3H]MTX), [3H]MTX-human serum albumin (HSA) conjugates, and small (mean volume diameter, 10.0 μm) and large (mean volume diameter, 22.4 μm) size hydrophilic albumin microspheres (HAMs) containing different ratios of [3H]MTX-HSA conjugates to [3H]MTX was evaluated after i.v. administration of the compounds, equivalent to 150 nCi via the tail vein of mice. The total radioactivity in the lung increased immediately in a few minutes after i.v. injection of the both small and large HAMs, and then declined for up to 3-4 weeks, apparently reaching a plateau thereafter. However, the radioactivity in the liver, spleen and kidney increased slowly during the rapid decrease in radioactivity in the lung. This suggested that the ...
The IMpassion130 trial was a global, randomised, double-blind, phase III study of atezolizumab+nab-paclitaxel versus placebo+nab-paclitaxel in patients with treatment naive locally advanced or metastatic triple-negative breast cancer. Here, progression-free survival was statistically significantly longer in patients treated with the combination of atezolizumab+nab-paclitaxel compared with placebo+nab-paclitaxel. The side effect profile was favourable as no unexpected toxicities were observed in the intervention compared with the control arm. In the current podcast, PS provides insight on the response rate and the preliminary survival analysis of IMpassion130. Further possible biomarkers and the impact of the results on the treatment standard in breast cancer are discussed.. ...
This work is a continuation of electrophoretic investigations aimed at revealing a wild relative ofVicia faba. Electrophoretic analysis (PAGE) of seed albumins covered 52 accessions representing eightVicia species of sect.Hypechusa and two species of sect.Peregrinae. Most of the examined species showed an intraspecific variation due to differences between accessions and/or individual variation within accessions. In spite of the intraspecific variation, marked interspecific differences were recorded. However, none of the investigated species displayed electrophoretic seed albumin patterns similar to those reported earlier forV. faba. Contribution of the obtained results to characterization of the examined taxa is discussed.
Low wall shear stress (WSS) is implicated in endothelial dysfunction and atherogenesis. The accumulation of macromolecules is also considered as an important factor contributing to the development of atherosclerosis. In the present study, a fluid-wall single-layered model incorporated with shear-dependent transport parameters was used to investigate albumin and low-density lipoprotein (LDL) transport in an in vivo computed tomographic image-based human right coronary artery (RCA). In the fluid-wall model, the bulk blood flow was modeled by the Navier-Stokes equations, Darcys law was employed to model the transmural flow in the arterial wall, mass balance of albumin and LDL was governed by the convection-diffusion mechanism with an additional reaction term in the wall, and the Kedem-Katchalsky equations were applied at the endothelium as the interface condition between the lumen and wall. Shear-dependent models for hydraulic conductivity and albumin permeability were derived from experimental ...
Serum albumin is the most abundant plasma protein and has a long half-life due to neonatal Fc receptor (FcRn)-mediated transcytosis by many cell types, including proximal tubule cells of the kidney. Albumin also interacts with, and is modified by, many small and large molecules. Therefore, the focus of the present study was to address the impact of specific known biological albumin modifications on albumin-FcRn binding and cellular handling. Binding at pH 6.0 and 7.4 was performed since FcRn binds albumin strongly at acidic pH and releases it after transcytosis at physiological pH. Equilibrium dissociation constants were measured using microscale thermophoresis. Since studies have shown that glycated albumin is excreted in the urine at a higher rate than unmodified albumin, we studied glucose and methylgloxal modified albumins (21 days). All had reduced affinity to FcRn at pH 6.0, suggesting these albumins would not be returned to the circulation via the transcytotic pathway. To address why ...
This study looks into the distinctions between albumin-water, natural rubber-hydroxide, blends of each plastic, and tensile properties of albumin concentration after application of tissue. With lower content of both water and glycerol, the two studies showed anti-inflammatory effect and accumulation effect. The second interaction between albumin was most likely due to the albumin protein itself. This peak albumin in the waters cell membrane could have been due to the presence of different polymers. For instance, the first peak seen at 30c was the initial degradation of the protein in the plastic. However, after the addition of moisture, the plastics maintained a high moisture content after 90 hours of molding. Overall, based on the previous data, it was found that after conditioning for 20h, the plastics would maintain consistent values.. This loss in moisture content was due to the loss of water from heat, using a larger plastic, and more. It could render this plastic frame useful for the ...
Is overamplification of the conventional macrophage defensive position critical to generic 130 mg malegra dxt amex impotence for males lesion growth? Southeast zygosity for factor V R506Q and prothrombin G20210A Asian J Trop Med Public Health 1993;24(Suppl 1):92?5 order malegra dxt no prescription erectile dysfunction causes weight. In addition to buy discount malegra dxt on line beta blocker causes erectile dysfunction the lower number of blood cells within the circulation, the cells may be myelodysplasia merely implies that the mature blood cells found within the bone marrow or circulating within the blood ?look funny. Drugs for breast most cancers that has unfold (superior breast most cancers) q Taxanes, such as paclitaxel (Taxol), docetaxel (Taxotere), and albumin-bound paclitaxel (Abraxane) q Anthracyclines (Doxorubicin, pegylated liposomal doxorubicin, and Epirubicin) q Platinum brokers (cisplatin, carboplatin) q Vinorelbine (Navelbine) q Capecitabine (Xeloda) q Gemcitabine (Gemzar) q ...
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Urinary excretion of albumin indicates kidney damage and is recognized as a risk factor for progression of kidney disease and cardiovascular disease. The role of urinary albumin measurements has focused attention on the clinical need for accurate and clearly reported results. The National Kidney Disease Education Program and the IFCC convened a conference to assess the current state of preanalytical, analytical, and postanalytical issues affecting urine albumin measurements and to identify areas needing improvement. The chemistry of albumin in urine is incompletely understood. Current guidelines recommend the use of the albumin/creatinine ratio (ACR) as a surrogate for the erro-prone collection of timed urine samples. Although ACR results are affected by patient preparation and time of day of sample collection, neither is standardized. Considerable intermethod differences has been reported for both albumin and creatinine measurement, but trueness is unknown because there are no reference measurement
Background: Inflammatory markers such as C-reactive protein and Albumin have previously been associated with poor prognosis in ST-elevation myocardial infarction (STEMI). Objective: The present study aims to investigate the relationship between the in
The global Albumin (Human) Market research report portrays a deep analysis of the global Albumin (Human) market. The market value is calculated by analyzing the revenue (USD Million) and size (k.MT) of the global Albumin (Human) market. The report covers the recent technological trends and key industry improvements of the Albumin (Human) market. It also demonstrates the analysis of the restraints, new opportunities, and drivers of the global Albumin (Human) market. The research report profiles the key players in the Albumin (Human) market operating across the globe. The dominating players in the Albumin (Human) market are CSL Behring, Baxter, Grifols, Octapharma, Zhongsheng Group, Taibang Bio, Shanghai Laishi, Hualan Bio. Click Here To Access The Report: https://www.reportsbuzz.com/request-for-sample.html?repid=61173. The report covers a review of recent developments and volume of all market segments. It uses SWOT analysis to estimate the current Albumin (Human) market trends. The report ...
Stem cell therapy is a cutting-edge therapeutic field, but still young and with a lot of room for optimization to ensure they reach patients. Recombinant human albumin offers a safe solution for optimized cell performance. As an animal and human component free product it provides regulatory benefits while improving cell viability and controlling batch-to-batch consistency. In this webinar, we will share examples of how using a ultra-pure recombinant human albumin source in the down-stream processing of cell therapies offers advantages along the entire value chain ...
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The addition of pyruvate to the culture medium has been reported to improve the maintenance of P450-dependent enzyme expression in primary rat hepatocyte cultures. In this study, the effects of 30mM pyruvate on cell morphology, albumin secretion and glutathione Stransferase (GST) expression were investigated as a function of the time in culture. The effect of triiodothyronine (T3) exposure on GST expression was also measured in pyruvate-treated cultures. Transmission electron microscopy showed that untreated hepatocytes deteriorated after culture for 7 days, whereas the morphology of the pyruvate-treated cells was similar to that observed in intact liver tissue. The albumin secretion rate was significantly higher in rat hepatocytes exposed to pyruvate than in control cells. In the presence of pyruvate, μ and α class GST activities were well maintained, whereas GST π activity was increased over the entire culture period. HPLC analysis revealed that the complement of GST subunits present in ...
Subunit vaccines have been investigated in over 1000 clinical trials of cancer immunotherapy, but have shown limited efficacy. Nanovaccines may improve efficacy but have rarely been clinically translated. By conjugating molecular vaccines with Evans blue (EB) into albumin-binding vaccines (AlbiVax), here we develop clinically promising albumin/AlbiVax nanocomplexes that self-assemble in vivo from AlbiVax and endogenous albumin for efficient vaccine delivery and potent cancer immunotherapy. PET pharmacoimaging, super-resolution microscopies, and flow cytometry reveal almost 100-fold more efficient co-delivery of CpG and antigens (Ags) to lymph nodes (LNs) by albumin/AlbiVax than benchmark incomplete Freunds adjuvant (IFA). Albumin/AlbiVax elicits ~10 times more frequent peripheral antigen-specific CD8+ cytotoxic T lymphocytes with immune memory than IFA-emulsifying vaccines. Albumin/AlbiVax specifically inhibits progression of established primary or metastatic EG7.OVA, B16F10, and MC38 tumors; ...
Albumin is a blood protein. The word albumin comes from the Latin for egg white (egg white contains albumin, which is one reason why eggs are a rich source of protein). Albumin is produced in the liver. It is important in the maintenance of blood consistency and regulating blood pressure, and in the transmission of certain nutrients through the bloodstream. Its reasonable to say that this is a very important substance in the blood.. Test. A test for albumin is useful in the diagnosis of many different illnesses. Low levels of albumin can be an indicator of kidney dysfunction. Thats because healthy kidneys that are functioning properly leave albumin in the blood for the most part while removing waste substances. A low serum albumin level combined with the detection of higher than normal levels of albumin in urine shows that the kidneys are not doing this properly.. Causes. Other causes of low albumin include certain liver diseases such as liver cancer or hepatitis. This can interfere with the ...
This trial is investigating the efficacy and tolerability of paclitaxel [Abraxane] combined with gemcitabine in patients with metastatic breast cancer.
What is Protein bound paclitaxel (Abraxane) ? Source: National Cancer Institute protein-bound paclitaxel (PROH-teen... PAK-lih-TAK-sil) A drug used to treat
After much discussion between the four of us (Me, Mark & Sarah) and Dr. Anderson, we are changing up my treatment plan after my chemo vaca week next week. Ill have a weekly infusion of Carboplatin (the dreaded one that sets me back so, but a much lower dose), along with a new drug, Abraxane. The Abraxane will cause me to have a new short cool do for the summer (baldness) :-), and possibly neuropathy. But we are looking to keep things moving in the right direction, since I have probably gotten the most out of the current plan at 4 cycles, and hopefully we will see tumor reduction of the breast with the change to Abraxane. It is hard on the blood too, so although it is a weekly infusion, Dr. Anderson says chances are Ill need a Nupagen shot now and then, which will add delays into the weekly schedule now and again. But the Abraxane should be easier to tolerate, even with the Carboplatin, since it will be a much smaller dose of that one ...
In this trial, the safety of combination treatment of Adriamycin plus cyclophosphamide followed by Abraxane as adjuvant therapy will be evaluated in pat
The degree of permeability of the blood-brain barrier can be evaluated by the quantitative measurements of albumin in the CSF and the serum on specimens obtained at the same time. Albumin is a particularly suitable indicator of protein because it is neither synthesized nor metabolized intrathecally. In CSF that is free of blood contamination, therefore, albumin must necessarily have come from plasma through the blood-brain barrier.. Using the results of quantitative CSF and serum albumin assays, a CSF (in mg/dL)/serum (in g/dL) albumin index can be calculated. An index value ,9 is considered consistent with an intact barrier. Values of 9-14 are interpreted as slight impairment, 14−30 as moderate impairment, and 30−100 as severe impairment. Values ,100 indicate complete breakdown of the barrier.1 ...
URINE Albumin Urine with protein or albumin is related to Hypertension or Diabetic. Kidneys normally prevent large molecules such as albumin from being excreted in the urine, high levels of urinary albumin excretion, called albuminuria, also indicates kidney is some how not functioning properly. It also reflects dysfunction of endothelial cells throughout the body, which…
International Protein Natural Egg White Albumen Protein is an easily absorbed whole food protein with an excellent amino acid profile which is still considered the gold standard of protein supplements. It is a medium release protein which makes it great for a betwee
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Tissue-resident memory T cells (TRMs) can profoundly enhance mucosal immunity, but parameters governing TRM induction by vaccination remain poorly understood. Here, we describe an approach exploiting natural albumin transport across the airway epithelium to enhance mucosal TRM generation by vaccination. Pulmonary immunization with albumin-binding amphiphile conjugates of peptide antigens and CpG adjuvant (amph-vaccines) increased vaccine accumulation in the lung and mediastinal lymph nodes (MLNs). Amph-vaccines prolonged antigen presentation in MLNs over 2 weeks, leading to 25-fold increased lung-resident T cell responses over traditional immunization and enhanced protection from viral or tumor challenge. Mimicking such prolonged exposure through repeated administration of soluble vaccine revealed that persistence of both antigen and adjuvant was critical for optimal TRM induction, mediated through T cell priming in MLNs after prime, and directly in the lung tissue after boost. Thus, vaccine ...
* found in: SIGMA Albumin from bovine serum, lyophilized powder, essentially fatty acid free, =96% (agarose gel electrophoresis), SIGMA Albumin from bovine..
Human Albumin SimpleStep ELISA® Kit is a highly sensitive (0.1 ng/ml), single-wash 90 min immunoassay suitable for Cell culture supernatant, Serum, Hep Plasma, EDTA Plasma, Cit plasma samples.
The neurotoxicity of albumin was studied in the rat. Solutions of rat albumin (3, 10 and 30 mg/ml) essentially free of fatty acids and globulins were injected into one neostriatum, physiological saline into the other. Injections were also performed with sodium glutamate (10 and 30 mM). Both albumin …
Serum albumin purification[edit]. Of many uses of affinity chromatography, one use of it is seen in affinity purification of ... In affinity purification of serum albumin, the stationary used for collecting or attracting serum proteins can be Cibacron Blue ... This type of purification is helpful in removing excess albumin and α2-macroglobulin contamination, when performing mass ... Naval, Javier; Calvo, Miguel; Lampreave, Fermin; Piñeiro, Andrés (1983-01-01). "Affinity chromatography of serum albumin: An ...
Albumin[edit]. Albumin is the major fraction in a normal SPEP. A fall of 30% is necessary before the decrease shows on ... Absence of albumin, known as analbuminaemia, is rare. A decreased level of albumin, however, is common in many diseases, ... Increased AMG is also noted in rats with no albumin indicating that this is a response to low albumin rather than nephrotic ... Albumin - alpha-1 interzone[edit]. Even staining in this zone is due to alpha-1 lipoprotein (high density lipoprotein - HDL). ...
Albumin historia[muokkaa , muokkaa wikitekstiä]. Nauhoittaminen ja julkaisu[muokkaa , muokkaa wikitekstiä]. Rumpali Steven ... Vaihtoehtoisesti hän esitti kahden tupla-albumin - tässä tapauksessa siis Use Your Illusion I:n ja Use Your Illusion II:n - ... Albumin on tuottanut Mike Clink, ja se julkaistiin 17. syyskuuta vuonna 1991 samanaikaisesti yhtyeen neljännen studioalbumin, ... Albumin avausraita "Right Next Door to Hell" kertoo Rosen mukaan hänen jatkuvasta vihasuhteestaan pakkomielteiseen naapuriinsa. ...
Albumin single[muokkaa , muokkaa wikitekstiä]. Vuosi Kappale Billboard Hot 100 Hot R&B/Hip-Hop Singles & Tracks ... Albumin kaikki kappaleet ovat ennen julkaisemattomia. Still I Risen julkaisi 14. joulukuuta 1999 Interscope Records, Death Row ... ". "Baby Don't Cry (Keep Ya Head Up II)" on myös albumin ainoa kappale, josta kuvattiin musiikkivideo. ...
Albumin tuotti Martin Birch, ja levy-yhtiö EMI julkaisi albumin Euroopassa 11. huhtikuuta 1988. Yhdysvalloissa albumin julkaisi ... Albumin kahdeksasta kappaleesta kolmea säveltänyt Adrian Smith erosi yhtyeestä albumin kiertueen jälkeen. ... Albumin teema, sanoitukset ja synty[muokkaa , muokkaa wikitekstiä]. »Se oli meidän seitsemäs studiolevy, eikä mulla ollut sille ... Albumin kappaleista "Can I Play with Madness" (Britannian singlelistan 3.), "The Evil That Men Do" (brittilistan 5.) ja "The ...
Albumin konsepti[muokkaa , muokkaa wikitekstiä]. Albumin peruskonsepti on erittäin tummanpuhuva. Sanoitukset käsittelevät ... Albumin myötä yhtye nousi suureen suosioon ja siitä tuli yksi grunge-musiikin johtavista kokoonpanoista. Albumi käsittelee ... Monet albumin sanoituksista, eritoten kappaleet "God Smack", "Angry Chair" ja "Junkhead", puivat laulaja Layne Staleyn ... Albumin viimeinen kappale "Would?" on Cantrellin kunnianosoitus vuonna 1990 kuolleelle Andrew Woodille. ...
Kyseisessä julkaisussa albumin nimi on kuitenkin Alive IV: The Millenium Concert. Kappalelista[edit , edit source]. Levy 1[edit ... sillä albumin julkaisusta tiedotettiin jo vuonna 1999[2]. Albumin kansitaide ehdittiin jo paljastaa, ja levylle konsertissa ... Albumin taustaa[edit , edit source]. Kissin alkuperäisen eli Gene Simmonsin, Paul Stanleyn, Peter Crissin ja Ace Frehleyn ... Albumin tuotti Mark Opitz[1], ja se on yhtyeen Alive-livealbumisarjan neljäs osa. ...
tammikuuta 2012.[14] Albumin nimi, MDNA on näennäinen lyhenne Madonnan nimestä.[15][16] Albumin nimestä nousi pian nimen ... Kansikuva ja albumin nimeäminen[muokkaa , muokkaa wikitekstiä]. Madonna julkisti uuden albuminsa nimen The Graham Norton ... Albumin avaussingle Give Me All Your Luvin' vuosi internetiin 8. marraskuuta nimellä "Give Me All Your Love".[5] 15. joulukuuta ... Albumin ensimmäinen single, "Give Me All Your Luvin'", julkaistiin helmikuun 3. päivä digitaalisesti.[3] Singlen demo vuosi ...
... albumin, transferrin and transthyretin: a practical, simple and clinically relevant approach in a large cohort". Journal of ... "Transcriptional regulation of transferrin and albumin genes by retinoic acid in human hepatoma cell line Hep3B". The ...
Serum albumin. *Human serum albumin. *Bovine serum albumin. *Prealbumin. Other. *C-reactive protein ...
... is known to be plasma protein bound to albumin, SHBG, and CBG.[4][5][6] ...
... , also known as "whey protein", is the albumin contained in milk and obtained from whey. Lactalbumin is found in the ... Serum proteins, including albumin, remained unchanged and within normal range, indicating that protein replenishment per se was ... The presence in the serum albumin fraction of glutamylcysteine groups (rare in food protein) and the specific intramolecular ... Whey protein concentrate was prepared so that the most thermosensitive proteins, such as serum albumin which contains 6 ...
albumin. *α1-acid glycoprotein. *lipoproteins. Some drug interactions with warfarin are due to changes in protein binding.[16] ...
In medicine, it is known as the primary carrier of basic (positively charged) drugs (whereas albumin carries acidic (negatively ... Aging causes a small decrease in plasma albumin levels; if anything, there is a small increase in alpha-1-acid glycoprotein. ... the other three are albumin, very low-density lipoprotein particle size, and citrate).[7] ...
Albumin- oids Crude Fiber Extractive Matter Free From Nitrogen Fat Meadow hay- poor 14.3 5.0 7.5 33.5 38.2 1.5 ...
Albumin , 4.0 g/dl. *White blood count ≥ 15,000/µl. Other studies have reported the following to be the most important adverse ...
... is highly plasma protein bound, 99% bound to albumin. Albumin is the most abundant protein found in human plasma ... "plasma albumin". TheFreeDictionary.com. Saunders. Retrieved 7 January 2018. de Vries HE, Kuiper J, de Boer AG, Van Berkel TJ, ...
Rhian Daly (August 15, 2014). "Celebration - 'Albumin'". Nme.com. Retrieved April 29, 2018. T. Ballard Lesemann (October 24, ... Albumin - (August, 2014) Wounded Healer - (June, 2017) "Diamonds" - (December 5, 2005) "War" - (February 20, 2006) "New Skin ...
For example, this technique is used to investigate how fatty acids bind to serum albumin (a highly abundant blood protein), ... Berde CB, Hudson BS, Simoni RD, Sklar LA (January 1979). "Human serum albumin. Spectroscopic studies of binding and proximity ... which will compete for binding sites on serum albumin. α-Parinaric acid has been used to study the hydrophobicity and foaming ... binding to bovine serum albumin". Biochemistry. 16 (23): 5100-8. doi:10.1021/bi00642a024. PMID 911814. ...
Poznansky, M. J. (1984). "Enzyme-albumin polymers. New approaches to the use of enzymes in medicine". Applied Biochemistry and ...
album-in 1922. Molecular studies have shown that the current species concept for H. repandum needed revision as there was a ...
... , or trenbolone cyclohexylmethylcarbonate, sold under the brand names Parabolan and Hexabolan, is a synthetic, injected anabolic-androgenic steroid (AAS) of the nandrolone group and an androgen ester - specifically, the C17β hexahydrobenzylcarbonate (cyclohexylmethylcarbonate) ester of trenbolone - which was marketed in France for medical use in humans but has since been discontinued.[1] It was introduced in France in 1980 and was voluntarily discontinued by its manufacturer in 1997.[1][2] The drug acts as a long-lasting prodrug of trenbolone when administered via intramuscular injection.[1] It was used clinically at a dosage of one ampoule (76 mg, corresponding to 50 mg trenbolone base) every 10 days.[1] ...
Androstenedione immunogens: Androvax (androstenedione albumin). *Ovandrotone albumin (Fecundin). *#WHO-EM. *‡Withdrawn from ...
InChI=1S/C29H31NO4/c1-20-26-14-11-24(32)19-27(26)34-29(28(20)21-5-9-23(31)10-6-21)22-7-12-25(13-8-22)33-18-17-30-15-3-2-4-16-30/h5-14,19,29,31-32H,2-4,15-18H2,1H3/t29-/m0/ ...
The Women's Health Initiative trials were conducted between 1991 and 2006 and were the first large, double-blind, placebo-controlled clinical trials of HRT in healthy women.[52] Their results were both positive and negative, suggesting that during the time of hormone therapy itself, there are increases in invasive breast cancer, stroke and lung clots. Other risks include increased endometrial cancer, gallbladder disease, and urinary incontinence, while benefits include decreased hip fractures, decreased incidence of diabetes, and improvement of vasomotor symptoms. There also is an increased risk of dementia with HRT in women over 65, though when given earlier it appears to be neuroprotective. After the cessation of HRT, the WHI continued observe its participants, and found that most of these risks and benefits dissipated, though some elevation in breast cancer risk did persist.[24] Other studies have also suggested an increased risk of ovarian cancer.[43] The arm of the WHI receiving combined ...
The plasma protein binding of norethisterone is 97%.[4] It is bound 61% bound to albumin and 36% bound to SHBG.[4] ...
CDMT was the key steroid administered to approximately 10,000 athletes from East Germany (GDR) as secret official policy, often without their knowing the nature of the "vitamins" they were forced to take. The doping program was run by the East German Government from about 1968 until 1989 when the Berlin Wall was destroyed. The doping program was known as State Plan Topic 14.25. The doping was done in secret; it was only in the 1990s that Franke and Berendonk looked closely at the original archived information and discovered the true scope of just how well-planned and successful the doping regime had been (in terms of medal success and world record performances).[2] After the collapse of the East German regime, people responsible for the forced doping were found guilty of causing grievous bodily harm to about 10,000 sportspeople; victims were compensated. In later life former athletes developed serious health problems believed due to the drugs; psychotic episodes were attributed to CDMT.[3] ...
... (INN) (brand names Colpotrofin, Colpotrophine, Delipoderm), also known as estradiol 3-propyl 17β-methyl diether, is a synthetic steroidal estrogen which is used topically in a 1% cream formulation.[1][2][3][4] It is the 3-propyl and 17β-methyl diether of estradiol.[5] The drug is described as a tropic agent and antiseborrheic.[1] It has not been found to be effective in the treatment of androgenic alopecia or other conditions of cutaneous androgenization.[6][7] ...
... (INN, JAN) (brand names Steranabol Depo, Steranabol Ritardo; former developmental code name FI-5852), or oxabolone cypionate, also known as 4-hydroxy-19-nortestosterone 17β-cypionate or estr-4-en-4,17β-diol-3-one 17β-cypionate, is synthetic and injected anabolic-androgenic steroid (AAS) and derivative of nandrolone (19-nortestosterone) which has been marketed in Europe.[1][2][3] It is the C17β cypionate ester and a prodrug of oxabolone (4-hydroxy-19-nortestosterone).[2][3] ...
A 2017 population-based, matched-cohort study of 93,197 men aged 66 years and older with BPH found that finasteride and dutasteride were associated with a significantly increased risk of depression (HR, 1.94; 95% CI, 1.73-2.16) and self-harm (HR, 1.88; 95% CI, 1.34-2.64) during the first 18 months of treatment, but were not associated with an increased risk of suicide (HR, 0.88; 95% CI, 0.53-1.45).[31][32][33][21] After the initial 18 months of therapy, the risk of self-harm was no longer heightened, whereas the elevation in risk of depression lessened but remained marginally increased (HR, 1.22; 95% CI, 1.08-1.37).[31][32][21] The absolute increase in the rate of depression was 247 per 100,000 patient-years and of self-harm was 17 per 100,000 patient-years.[21][34] As such, on the basis of these findings, it has been stated that cases of depression in patients that are attributable to 5-ARIs will be encountered on occasion, while cases of self-harm attributable to 5-ARIs will be encountered ...
Serum albumin[edit]. Main article: Serum albumin. Serum albumin is the most abundant blood plasma protein and is produced in ... For the specific albumins found in vertebrate bloodstreams, see serum albumin. For other uses, see Albumin (disambiguation). ... Serum albumin levels[edit]. The normal range of human serum albumin in adults (, 3 y.o.) is 3.5 to 5 g/dL. For children less ... Wikisource has the text of the 1911 Encyclopædia Britannica article Albumin.. *Albumins at the US National Library of Medicine ...
ALBUMIN_1 (PS00212). Accession PS00212 Integration. Serum albumin, conserved site (IPR020857) Member database. PROSITE patterns ...
Albumin definition, any of a class of simple, sulfur-containing, water-soluble proteins that coagulate when heated, occurring ... albumin. in Science. albumin. [ăl-byōō′mĭn]. *A class of proteins found in egg white, milk, blood, and various other plant and ... albumin. in Medicine. albumin. (ăl-byōō′mĭn). n.. *A class of simple, water-soluble proteins that can be coagulated by heat and ... albumin. albumen. noun. *any of a group of simple water-soluble proteins that are coagulated by heat and are found in blood ...
InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites. We combine protein signatures from a number of member databases into a single searchable resource, capitalising on their individual strengths to produce a powerful integrated database and diagnostic tool.
I had a test done showing my albumin levels are a little low than normal. Can this be dangerous?? If so in what ... ... Albumin gopo92 Hello. I am 18 years ood and have been suffering from intestinal disease since 10 years. I had a test done ... Albumin is a protein produced by the liver and it forms an important part of the blood as it helps keep the water in the blood ... If your albumin were very low you then you would be increasingly worried that this value was representative of one of the ...
Is there a home test for albumin levels?. Not for blood albumin; you can test for high albumin levels in urine with a dipstick ... Albumin may also be ordered to evaluate a persons nutritional status.. When is it ordered?. An albumin test is frequently ... The urine albumin test (in the past, called a microalbumin test) detects and measures albumin in the urine as an early ... A low albumin level may be an indication that further investigation may be warranted. A low albumin may reflect a temporary ...
... with albumin) Injection: learn about side effects, dosage, special precautions, and more on MedlinePlus ... with albumin) injection. If you are female, you should use birth control during your treatment with paclitaxel (with albumin) ... Paclitaxel (with albumin) may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away: *pain ... Paclitaxel (with albumin) injection may cause a large decrease in the number of white blood cells (a type of blood cell that is ...
The role of albumin receptors in regulation of albumin homeostasis: Implications for drug delivery ... Interdomain zinc site on human albumin. Alan J. Stewart, Claudia A. Blindauer, Stephen Berezenko, Darrell Sleep, Peter J. ... Interdomain zinc site on human albumin. Alan J. Stewart, Claudia A. Blindauer, Stephen Berezenko, Darrell Sleep, Peter J. ... Interdomain zinc site on human albumin. Alan J. Stewart, Claudia A. Blindauer, Stephen Berezenko, Darrell Sleep, and Peter J. ...
A list of US medications equivalent to Human Albumin Demo is available on the Drugs.com website. ... Human Albumin Demo is a medicine available in a number of countries worldwide. ... Ingredient matches for Human Albumin Demo. Albumin Human. Albumin Human is reported as an ingredient of Human Albumin Demo in ... Human Albumin Demo. Human Albumin Demo may be available in the countries listed below. ...
Albumin: The Natural Choice for Diagnostic Tests The availability of established diagnostic kits has enabled researchers to ... The patent involves the formulation and use of recombinant human serum albumin and gluteraldehyde, and now becomes part of ... CryoLife purchases patent involving formulation, use of recombinant human serum albumin and gluteraldehyde CryoLife, Inc., an ... high quality Bovine Serum Albumin, to do contract filling & provide BSA to customers requiring less than Proliants standard 10 ...
ALBUMIN PHENOTYPES IN TURKEYS. Indalecio R. Quinteros, R. W. C. Stevens, C. Stormont and V. S. Asmundson ... ALBUMIN PHENOTYPES IN TURKEYS. Indalecio R. Quinteros, R. W. C. Stevens, C. Stormont and V. S. Asmundson ... ALBUMIN PHENOTYPES IN TURKEYS. Indalecio R. Quinteros, R. W. C. Stevens, C. Stormont and V. S. Asmundson ...
Serum albumin, often referred to simply as blood albumin, is an albumin (a type of globular protein) found in vertebrate blood ... Serum albumin is widely distributed in mammals. The human version is human serum albumin. Bovine serum albumin, or BSA, is ... Nephrotic syndrome patients are sometimes given albumin to replace the lost albumin. The general structure of albumin is ... Human serum albumin is encoded by the ALB gene. Other mammalian forms, such as bovine serum albumin, are chemically similar. ...
Albumin Antibody in Routine Rhesus Grouping Br Med J 1951; 1 :1490 ... Albumin Antibody in Routine Rhesus Grouping. Br Med J 1951; 1 doi: https://doi.org/10.1136/bmj.1.4721.1490 (Published 30 June ...
View more information on albumin>human serum albumin. ... Sigma-Aldrich has partnered with the technology holders of recombinant human albumin products expressed in Rice, Pichia Product Directory > Biochemicals and Reagents > Proteins and Derivatives > Albumin > Recombinant/Transgenic Human ... Albumin human recombinant, expressed in Pichia pastoris, 5% in aqueous buffer, ≥90% (SDS-PAGE) * pricing ...
This medicine works by increasing plasma volume or levels of albumin in the blood. Albumin is used to replace blood volume loss ... Medicinal albumin is made of plasma proteins from human blood. ... Albumin is a protein produced by the liver that circulates in ... What is albumin?. Albumin is a protein produced by the liver that circulates in plasma (the clear liquid portion of your blood ... How is albumin given?. Albumin is injected into a vein through an IV. A healthcare provider will give you this injection. ...
Preoperative albumin to globulin ratio predicts survival in clear cell renal cell carcinoma patients. In this retrospective ... The role of preoperative albumin to globulin ratio in predicting prognosis in testicular cancer patients. In recent years, the ... Prognostic role of pretreatment serum albumin in renal cell carcinoma: a systematic review and meta-analysis. Recently, many ... Thus, we examined the association of C-reactive protein (CRP), haptoglobin, albumin and white blood cells (WBC) with prostate ...
Make research projects and school reports about albumin easy with credible articles from our FREE, online encyclopedia and ... Principal forms are egg albumin (egg white), milk albumin and blood albumin. In a healthy human, it constitutes about 5% of the ... albumin (ălbyōō´mən) [Lat.,=white of egg], member of a class of water-soluble, heat-coagulating proteins. Albumins are widely ... Albumins occur in egg white (the protein component of which is known as albumen), blood, milk, and plants. Serum albumins, ...
Rate your experience with Albumin-Saline injection on - WebMD including the side effects, drug interactions, effectiveness, ...
Human serum albumin (HSA) is the intravenous protein most commonly used in the world for therapeutic ends. It is employed to ... Human serum albumin (HSA) is the intravenous protein most commonly used in the world for therapeutic ends. It is employed to ... Commercial albumin is currently extracted from blood, but the lack of sufficient reserves to cover all worldwide needs has ... While the price at the pharmacy of albumin produced using plasma is 4 euros per gram, that obtained from yeasts or mammal cells ...
Treatments and Tools for albumin. Find albumin information, treatments for albumin and albumin symptoms. ... albumin - MedHelps albumin Center for Information, Symptoms, Resources, ... Hi, My most recent tests came back with high lymphocytes (4.46X10) and high albumin (28.8 ... ... My 15 year olds results: albumin 4.71 globulin 2.23 a/g ratio 2.11 bilirubin total... ...
Using the results of quantitative CSF and serum albumin assays, a CSF (in mg/dL)/serum (in g/dL) albumin index can be ... Albumin is a particularly suitable indicator of protein because it is neither synthesized nor metabolized intrathecally. In CSF ... The degree of permeability of the blood-brain barrier can be evaluated by the quantitative measurements of albumin in the CSF ... Albumin, Cerebrospinal Fluid. 1746-7. 012230. Albumin, CSF. mg/dL. 1746-7. ...
Albumin is the most prevalent protein in your blood, and without it, you can experience a number of symptoms. ... The role of albumin in fluid balance and transport means low albumin levels can cause bodily problems that manifest in symptoms ... The albumin in your blood moves the mineral calcium, the hormone progesterone and medicines throughout your tissues. Albumin ... To maintain normal blood albumin ranges, you should have between 3.4 and 5.4 g/dL of albumin in your blood. ...
ALBUMIN HUMAN (UNII: ZIF514RVZR) (ALBUMIN HUMAN - UNII:ZIF514RVZR) ALBUMIN HUMAN. 12.5 g in 50 mL. ... Albumin (Human) 25% Solution AlbuRx® 25 Contains: 12.5 g Albumin (Human) in 50 mL of buffered diluent. Stabilized with 0.02 M ... One vial containing 12.5 grams of albumin. [NDC 44206-251-90]. 100 mL. 44206-251-10. One vial containing 25 grams of albumin. [ ... In all these settings, the circulating albumin mass is initially maintained by a gradual transfer of extravascular albumin to ...
Biochemically, the mutant was characterized by an extraordinarily low serum albumin content and a hyperlipidemia. Total serum ... Serum cholesterol was inversely correlated with a decrease in albumin; the correlation coefficient for ablumin was --.92. These ... rats may serve as a model of human familial analbuminemia and may also be useful in elucidating the functional roles of albumin ...
Learn about the known and possible side effects of Albumin Human Not everyone will experience one or all of these side effects ... Albumin Human - Information. Albumin Human is derived from human plasma, used to treat shock as a result of blood loss in the ... Side effect(s) of Albumin Human Read the side effects of Albumin Human as described in the medical literature. In case of any ... Albumin 20% (100ml) , Biseko , Biseko (50ml) , Granocyte , Roferon -A , Sll Human Albumin , Verglob 1000MG , Verglob 2500 , ...
NANOPARTICLE ALBUMIN-BOUND PACLITAXEL (Na no PAHR ti kuhl al BYOO muhn-bound PAK li TAX el) is a chemotherapy drug. ... Nanoparticle Albumin-Bound Paclitaxel injection. What is this medicine?. NANOPARTICLE ALBUMIN-BOUND PACLITAXEL (Na no PAHR ti ... an unusual or allergic reaction to paclitaxel, albumin, other chemotherapy, other medicines, foods, dyes, or preservatives ...
Albumin from hamster for your research needs. Find product specific information including CAS, MSDS, protocols and references. ...
Albumin Human (UNII: ZIF514RVZR) (Albumin Human - UNII:ZIF514RVZR) Albumin Human. 2.5 g in 50 mL. ... Albumin (Human). 5%, USP. albuked™ 5 Heated 60°C 10 hours. For Intravenous Infusion Only. This package contains: 12.5 g albumin ... Situations in Which Albumin Administration is Not Warranted(1) In chronic nephrosis, infused albumin is promptly excreted by ... it is common practice to adjust the albumin and crystalloid pump prime to achieve a hematocrit of 20% and a plasma albumin ...
Albumin human synonyms, Albumin human pronunciation, Albumin human translation, English dictionary definition of Albumin human ... albumin. (redirected from Albumin human). Also found in: Thesaurus, Medical, Encyclopedia.. Related to Albumin human: ... lactalbumin - albumin occurring in milk. serum albumin - albumin occurring in blood serum; serves to maintain the somatic ... albumen, albumin - Albumen is the white of an egg, from Latin albus, "white"; albumin is a protein within the albumen.. See ...
  • A number of blood transport proteins are evolutionarily related, including serum albumin, alpha-fetoprotein , vitamin D-binding protein and afamin . (wikipedia.org)
  • Serum albumin is the main protein of human blood plasma. (wikipedia.org)
  • Albumin comprises three homologous domains that assemble to form a heart-shaped protein. (wikipedia.org)
  • Serum albumin is the most abundant blood plasma protein and is produced in the liver and forms a large proportion of all plasma protein. (wikipedia.org)
  • The human version is human serum albumin , and it normally constitutes about 50% of human plasma protein. (wikipedia.org)
  • Albumin is a protein produced by the liver and it forms an important part of the blood as it helps keep the water in the blood vessels and also helps carry many substances in the blood. (medhelp.org)
  • Albumin is a protein made by the liver. (labcorp.com)
  • Levels of albumin may decrease, to a greater or lesser degree, when conditions interfere with its production by the liver, increase protein breakdown, increase protein loss via the kidneys, and/or expand the volume of plasma, the liquid portion of blood (diluting the blood). (labcorp.com)
  • Human types include: Human serum albumin is the main protein of human blood plasma. (wikipedia.org)
  • Extracellular matrix protein 1 is a less canonical albumin. (wikipedia.org)
  • They are not in the same family as vertebrate albumins: Ovalbumin is a storage protein in egg white (albumen). (wikipedia.org)
  • Albumin is a 65-70 kDa protein. (wikipedia.org)
  • A serum albumin test measures the amount of this protein in the clear liquid portion of the blood. (medlineplus.gov)
  • Serum albumin, often referred to simply as blood albumin, is an albumin (a type of globular protein) found in vertebrate blood. (wikipedia.org)
  • Serum albumin is produced by the liver, occurs dissolved in blood plasma and is the most abundant blood protein in mammals. (wikipedia.org)
  • Albumin functions primarily as a carrier protein for steroids, fatty acids, and thyroid hormones in the blood and plays a major role in stabilizing extracellular fluid volume by contributing to oncotic pressure (known also as colloid osmotic pressure) of plasma. (wikipedia.org)
  • Albumin is synthesized in the liver as preproalbumin which has an N-terminal peptide that is removed before the nascent protein is released from the rough endoplasmic reticulum. (wikipedia.org)
  • Albumin is a globular, water-soluble, un-glycosylated serum protein of approximate molecular weight of 65,000 Daltons. (wikipedia.org)
  • Bovine serum albumin, or BSA, is commonly used in immunodiagnostic procedures, clinical chemistry reagents, cell culture media, protein chemistry research (including venom toxicity), and molecular biology laboratories (usually to leverage its non-specific protein binding properties). (wikipedia.org)
  • RCSB Protein Data Bank : Molecule of the Month - Serum Albumin Albumin binding prediction Overview of all the structural information available in the PDB for UniProt: P02768 (Human Serum albumin) at the PDBe-KB. (wikipedia.org)
  • Albumin is a protein produced by the liver that circulates in plasma (the clear liquid portion of your blood). (rexhealth.com)
  • Ovalbumin is the main protein of egg‐white, lactalbumin occurs in milk, and plasma or serum albumin is one of the major blood proteins. (encyclopedia.com)
  • Serum albumin concentration is sometimes measured as an index of protein‐energy malnutrition . (encyclopedia.com)
  • Human serum albumin (HSA) is the intravenous protein most commonly used in the world for therapeutic ends. (scienceblog.com)
  • Commercial albumin is currently extracted from blood, but the lack of sufficient reserves to cover all worldwide needs has instigated researchers to look for new formulae to multiply this protein. (scienceblog.com)
  • Albumin is a particularly suitable indicator of protein because it is neither synthesized nor metabolized intrathecally. (labcorp.com)
  • Albumin is the most prevalent protein in your blood, and without it, you can experience a number of symptoms. (livestrong.com)
  • The common causes of hypoproteinemia are protein-calorie malnutrition, defective absorption in gastro-intestinal disorders, faulty albumin synthesis in chronic hepatic failure, increased protein catabolism postoperatively or with sepsis, and abnormal renal losses of albumin with chronic kidney disease. (nih.gov)
  • Albumin Human is derived from human plasma, used to treat shock as a result of blood loss in the body (hypovolemia), burns, low protein levels (hypoproteinemia) due to surgery or liver failure, adult respiratory distress syndrome, dialysis, and as an additional medicine in bypass surgery. (medindia.net)
  • Albumin is a transport protein and it may be useful in severe jaundice in hemolytic disease of the newborn. (nih.gov)
  • albumin is a protein within the albumen. (thefreedictionary.com)
  • Results are expressed as a ratio (%) of glycated albumin to total albumin, thus minimizing differences in protein concentrations between patients. (news-medical.net)
  • Albumin makes up about 60% of the total protein. (labtestsonline.org)
  • Produced by the liver, albumin serves a variety of functions including as a carrier protein for many small molecules and ions, as a source of amino acids for tissue metabolism, and as the principle component involved in maintaining osmotic pressure (preventing fluid from leaking out of blood vessels). (labtestsonline.org)
  • Some laboratories report total protein, albumin, and the calculated ratio of albumin to globulins, termed the A/G ratio. (labtestsonline.org)
  • The A/G ratio is calculated from measured total protein, measured albumin, and calculated globulin (total protein - albumin). (labtestsonline.org)
  • Paclitaxel albumin-stabilized nanoparticle formulation is a form of paclitaxel contained in nanoparticles (very tiny particles of protein ). (cancer.gov)
  • Albumin is the most abundant protein in the blood. (labtestsonline.org.uk)
  • An albumin test checks urine for a protein called albumin . (cigna.com)
  • However, the magnitude of these responses is dependent upon dietary protein and is insufficient to normalize serum albumin. (nih.gov)
  • The Northwestern scientists are conducting a controlled study of a new "artificial liver" that uses albumin -- a protein that is produced naturally by the body and is a major component of human blood plasma -- to remove toxins from the blood of patients in chronic liver failure who are comatose. (eurekalert.org)
  • Human serum albumin (HSA) is an abundant plasma protein that binds a remarkably wide range of drugs, thereby restricting their free, active concentrations. (rcsb.org)
  • Serum albumin , often referred to simply as albumin , is the most abundant plasma protein in humans and other mammals. (bionity.com)
  • Bovine serum albumin, or BSA, is commonly used in immunodiagnostic procedures, clinical chemistry reagents, cell culture media, protein chemistry research and molecular biology laboratories. (bionity.com)
  • Albumin is a protein that is present in the blood. (labtestsonline.org.uk)
  • Too little albumin is present to be detected by the usual simple urine test strip (sometimes called a protein dipstick). (labtestsonline.org.uk)
  • This is termed microalbuminuria because of the low but significant concentration of albumin in the urine, not because it is a smaller type of the protein. (labtestsonline.org.uk)
  • Albumin is a protein made in the liver that has many functions in the body. (livestrong.com)
  • In the book "Krause's Food and Nutrition Therapy," author Mary D. Litchford reports that albumin accounts for around 60 percent of protein found in blood plasma, or the liquid part of blood. (livestrong.com)
  • In a few cases, severe protein-energy malnutrition may lead to decreased serum albumin levels. (livestrong.com)
  • More recently, science shows that low albumin is highly related to the disease state rather than nutritional status, so the effectiveness of eating a high-protein diet or drinking nutritional supplements is questionable. (livestrong.com)
  • There are forms of malnutrition, such as kwashiorkor, defined as chronic negligible protein calorie intake, where restoring adequate protein and calorie intake is important in improving albumin levels. (livestrong.com)
  • Aside from such cases, however, as long as you consume a balanced diet that includes adequate protein -- 0.8 g per kilogram per day for the average individual without illness -- the food you eat will likely not have an effect on your albumin level. (livestrong.com)
  • We examined the impact of sevoflurane and isoflurane on the dimerization of human serum albumin (HSA), a protein with anesthetic binding sites that are well characterized. (hindawi.com)
  • Albumin is a major protein normally present in blood, but virtually no albumin is present in the urine when the kidneys are functioning properly. (labtestsonline.org)
  • A healthy liver transforms the protein a person ingests into albumin. (medicalnewstoday.com)
  • If albumin levels are found to be too high, it may indicate a person is eating a high protein diet or is dehydrated. (medicalnewstoday.com)
  • Approximately 0.28 nanomole equivalent EDB/milligram protein was associated with albumin. (cdc.gov)
  • From blood to the lab: the protein albumin is responsible for many vital processes in the human body. (medindia.net)
  • Albumin is a protein that is found in large quantities in the blood of all mammals. (medindia.net)
  • When albumin deficit is the result of excessive protein loss, the effect of administration of albumin will be temporary unless the underlying disorder is reversed. (rxlist.com)
  • In most cases, increased nutritional replacement of amino acids and/or protein with concurrent treatment of the underlying disorder will restore normal plasma albumin levels more effectively than administration of albumin solutions. (rxlist.com)
  • In conjunction with appropriate crystalloid therapy, BUMINATE 5%, Albumin (Human), 5% Solution may be useful for treatment of protein deficits after the initial 24-hour period following extensive burns. (rxlist.com)
  • The interaction between captopril, an inhibitor of angiotensin converting enzyme and human serum albumin, a principal plasma protein in the liver has been investigated in vitro under a simulated physiological condition by UV-vis spectrophotometry and fluorescence spectrometry. (scirp.org)
  • No randomised or controlled trial was identified comparing albumin to crystalloids (other than normal saline) or non-protein colloids, or a combination of both, in the treatment of symptomatic hypotension during dialysis. (cochrane.org)
  • To compare the benefits and harms of volume expansion with human albumin, alone or in combination with crystalloid or non-protein colloids, for treating IDH in haemodialysis patients. (cochrane.org)
  • Bovine serum albumin (BSA) is used extensively as a carrier protein to dilute antibodies and as a general protein blocking agent in immunoassays and immunodetection protocols. (thomassci.com)
  • We offer two options for the BSA protein standards: Bovine Serum Albumin Standard BSA standard (2mg/ml) prepared in saline buffer. (thomassci.com)
  • Serum and plasma albumin is carbohydrate free and comprises 55-62% of the protein present. (thomassci.com)
  • Chicken egg albumin is the major protein constituent of egg whites. (thomassci.com)
  • Using affinity chromatography and surface plasmon resonance analysis, we have identified cubilin, a 460-kDa receptor heavily expressed in kidney proximal tubule epithelial cells, as an albumin binding protein. (jci.org)
  • Oxidation of human serum albumin (HSA), the major plasma protein, occurs in chronic kidney disease and leads to further activation of neutrophils. (clinicaltrials.gov)
  • Here we report adsorption properties of two carbon-based materials, thermally expanded graphite (EGr) and graphene nanoplatelets (GnP), for bovine serum albumin (BSA), the most abundant blood plasma protein. (mdpi.com)
  • In nephrotic syndrome, very high amounts of albumin are lost through the kidneys. (labcorp.com)
  • A symptom of high albumin levels is dehydration because your cells might be taking in more water to balance the higher amounts of albumin in your blood. (livestrong.com)
  • But when the kidneys are damaged, abnormal amounts of albumin leak into the urine. (cigna.com)
  • If early kidney damage is not treated, larger amounts of albumin may leak into the urine. (cigna.com)
  • When the kidneys are working properly, only tiny amounts of albumin pass from the bloodstream into the urine. (labtestsonline.org.uk)
  • A long time before this amount of damage, small changes in the kidney allow very small, but abnormal amounts of albumin to leak through, often as a result of having diabetes . (labtestsonline.org.uk)
  • Dogs with a functional defect in cubilin excrete large amounts of albumin in combination with virtually abolished proximal tubule reabsorption, showing the critical role for cubilin in the uptake of albumin by the proximal tubule. (jci.org)
  • The role of albumin in fluid balance and transport means low albumin levels can cause bodily problems that manifest in symptoms. (livestrong.com)
  • In order to investigate a possible role of albumin in regulating NETosis in vitro, we examined the effects of albumin depletion on cultured neutrophils. (nature.com)
  • The solid-phase antibody is reacted with a urine specimen, and the urine albumin-antigen complexes with the solid-phase antibody. (cdc.gov)
  • the fluorescence is directly proportional to the amount of urine albumin present. (cdc.gov)
  • Note: See Analytical Note on comparing the urine albumin-creatinine ratio of the random urine (first collection) and the follow-up first-morning void urine (second collection). (cdc.gov)
  • Urine albumin-creatinine ratio is used to classify stages of chronic kidney disease. (cdc.gov)
  • The ratio of urine albumin to urine creatinine is used to predict nephropathy risk in diabetic patients. (cdc.gov)
  • The urine albumin-antigen complexes with the solid-phase antibody. (cdc.gov)
  • The urine albumin test (formerly called microalbumin) detects and measures the amount of albumin in the urine to screen for kidney disease. (labtestsonline.org)
  • Sigma-Aldrich has partnered with the technology holders of recombinant human albumin products expressed in Rice, Pichia , and Saccharomyces to manufacture and distribute both research grade as well as custom bulk manufacturing grades. (sigmaaldrich.com)
  • Results of the fluorescent immunoassay (FIA) are reproducible, and the test is accurate and sensitive for the detection of human urinary albumin excretion. (cdc.gov)
  • Because urinary albumin excretion follows a circadian rhythym, the preferred method to collect urine for albumin assessment is to collect a 24 hour urine specimen. (cdc.gov)
  • Since the ACR depends not only on urinary albumin but also on urinary creatinine excretion, it will be affected by gender and age because muscle mass is lower in females than in males and decreases with age. (cdc.gov)
  • The nephrotic syndrome is characterized by the increased urinary excretion of albumin and of other serum proteins of intermediate molecular weight accompanied by a decrease in their serum concentration. (nih.gov)
  • In type 2 diabetics with microalbuminuria, irbesartan reduces albumin excretion independent of its antihypertensive effect. (diabetesincontrol.com)
  • Angiotensin-converting enzyme (ACE) inhibitors delay the progression from incipient to overt diabetic nephropathy and reduce albumin excretion rate (AER), independently of blood pressure,' write Ferdinando C. Sasso, MD, PhD, and colleagues from the Second University of Naples in Italy. (diabetesincontrol.com)
  • In addition, we find that mice lacking the endocytic receptor megalin show altered urinary excretion, and reduced tubular reabsorption, of albumin. (jci.org)
  • The rate constant for urinary excretion (k(10)) was slightly reduced by the preceding surgery, by a marked rise in plasma albumin, and by a high preinfusion urinary concentration of creatinine. (diva-portal.org)
  • Additionally, an albumin test may be ordered as part of a liver panel to evaluate liver function or with a creatinine , blood urea nitrogen (BUN) , or renal panel to evaluate kidney function. (labcorp.com)
  • Results of albumin testing are evaluated along with those from other tests done at the same time, such as the tests included in a CMP , basic metabolic panel (BMP) , liver panel , or renal panel . (labcorp.com)
  • This medicine is also used to treat low albumin levels caused by surgery, dialysis, abdominal infections, liver failure, pancreatitis, respiratory distress, bypass surgery, ovarian problems caused by fertility drugs, and other many other conditions. (rexhealth.com)
  • The liver then uses these proteins to create albumin, which is then circulated through the body. (livestrong.com)
  • Albumin also moves bilirubin, a yellow pigment and bile byproduct created in the liver, throughout your body. (livestrong.com)
  • Certain conditions such as liver disease can contribute to low albumin levels because liver disease impairs the body's ability to create proteins. (livestrong.com)
  • (1) This could also be of importance in acute liver failure where albumin might serve the dual role of supporting plasma oncotic pressure, as well as binding excessive plasma bilirubin. (nih.gov)
  • An albumin blood level test is typically done to test liver and kidney function. (reference.com)
  • Albumin is made in the liver and is extremely sensitive to liver damage. (labtestsonline.org.uk)
  • The concentration of albumin drops when the liver is damaged, when a person is malnourished, or if a person experiences inflammation in the body. (labtestsonline.org.uk)
  • CHICAGO --- Adding albumin to a dialysis solution may help patients wake up faster from coma due to chronic liver failure, according to researchers at Northwestern University Medical School. (eurekalert.org)
  • When the body is under inflammatory stress, the liver focuses on producing inflammatory proteins, like cytokines, rather than albumin. (livestrong.com)
  • In addition to decreased production by the liver, albumin that has already been produced and entered the bloodstream may be broken down for use in making proteins that will help fight the illness. (livestrong.com)
  • The TCA soluble fractions of kidney and liver tissues from rats injected with acrolein adducted albumin contained more radioactivity than those from rats injected with native albumin. (cdc.gov)
  • The authors conclude that the albumin/acrolein adduct is cleared more rapidly from the circulation and degraded more rapidly by the liver and kidney than native albumin. (cdc.gov)
  • Pseudo colored Green immunofluorescence staining of paraffin embedded rabbit liver with purified ab106582 Anti-Albumin at a working dilution of 1 in 100. (abcam.com)
  • If the results indicate an abnormal amount of albumin, it may suggest a problem with the liver or kidneys. (medicalnewstoday.com)
  • The liver releases albumin as part of its normal functioning. (medicalnewstoday.com)
  • When the liver is not functioning correctly, this process decreases and may lead to a drop in albumin levels. (medicalnewstoday.com)
  • A doctor will typically administer a serum albumin test if symptoms of liver disease or other liver problems are present. (medicalnewstoday.com)
  • In-vitro analysis involved incubation of human plasma or purified albumin with EDB in the presence of phenobarbital treated rat liver microsomes and an NADPH generating system for 2 hours. (cdc.gov)
  • Preoperative albumin to globulin ratio predicts survival in clear cell renal cell carcinoma patients. (urotoday.com)
  • In this retrospective analysis, we evaluated associations between albumin to globulin ratio (AGR), clinicopathological characteristics, and survival in 592 patients with localized or locally advanced clear cell renal cell carcinoma (CCRCC) prior to nephrectomy. (urotoday.com)
  • This observation is consistent with a hypothesis that increased renal catabolism contributes to total albumin catabolism in nephrosis. (nih.gov)
  • Effect of intravenous albumin on renal impairement and mortality in patients with cirrhosis and spontaneous bacterial peritonitis. (medicin.dk)
  • What they showed was that if you had less than 30 mg of albumin in your urine, your chances of going onto end stage renal disease was zero, almost zero. (diabetesincontrol.com)
  • Also, by immunoblotting and immunocytochemistry we show that previously identified low-molecular-weight renal albumin binding proteins are fragments of cubilin. (jci.org)
  • This process may prove important for understanding interstitial renal inflammation and fibrosis caused by proximal tubule uptake of an increased load of filtered albumin. (jci.org)
  • Endotoxemia in renal insufficiency leads to impaired neutrophil function and to increased albumin oxidation. (clinicaltrials.gov)
  • albumin ( albumen ) A group of relatively small proteins which are soluble in water and readily coagulated by heat. (encyclopedia.com)
  • ALBUMIN , or Albumen (Lat. (wikisource.org)
  • It specifically measures both glycated albumin (enzymatic) and total albumin (BCP) in separate reactions. (news-medical.net)
  • A defect in this property results in nephrotic syndrome leading to albumin loss in the urine. (wikipedia.org)
  • Nephrotic syndrome patients are sometimes given albumin to replace the lost albumin. (wikipedia.org)
  • Metabolism of albumin and immunoglobulins in the nephrotic syndrome. (nih.gov)
  • AlbuRx ® 25, Albumin (Human) 25% solution is a sterile aqueous solution for intravenous administration containing the albumin component of human blood. (nih.gov)
  • AlbuRx ® 25, Albumin (Human) 25% solution should not be used as an intravenous nutrient because of the slow breakdown and relatively unfavorable composition of the albumin molecule with respect to its content of essential amino acids. (nih.gov)
  • Human serum albumin, at 2 g/kg, administered over 2 hours by intravenous infusion, will be compared to placebo (isovolumic normal saline) among patients with acute ischemic stroke. (clinicaltrials.gov)
  • BUMINATE 5%, Albumin (Human), 5% Solution is a sterile, nonpyrogenic preparation of albumin in a single dosage form for intravenous administration. (rxlist.com)
  • Aims A population kinetic model was developed for the body fluid shifts occurring when 20% albumin is given by intravenous infusion. (diva-portal.org)
  • Methods An intravenous infusion of 3 mL/kg 20% albumin over 30 minutes was given to 15 volunteers and to 15 patients on the 1(st) day after major open abdominal surgery. (diva-portal.org)
  • Albumins are commonly found in blood plasma and differ from other blood proteins in that they are not glycosylated . (wikipedia.org)
  • Serum albumins are important in regulating blood volume by maintaining the oncotic pressure (also known as colloid osmotic pressure ) of the blood compartment. (wikipedia.org)
  • Albumins are widely distributed in plant and animal tissues, e.g., ovalbumin of egg, myogen of muscle, serum albumin of blood, lactalbumin of milk, legumelin of peas, and leucosin of wheat. (factmonster.com)
  • Separation of serum albumins from other blood proteins can be carried out by electrophoresis or by fractional precipitation with various salts. (factmonster.com)
  • Albumins and other proteins of the blood aid significantly in regulating the distribution of water and maintenance of proper osmotic pressure in the body. (factmonster.com)
  • This test measures the level of albumin in the blood. (labcorp.com)
  • Albumin keeps fluid from leaking out of blood vessels, nourishes tissues, and transports hormones, vitamins, drugs, and substances like calcium throughout the body. (labcorp.com)
  • Albumin is present in high concentrations in the blood, and when the kidneys are functioning properly, virtually no albumin is lost in the urine. (labcorp.com)
  • Paclitaxel (with albumin) injection may cause a large decrease in the number of white blood cells (a type of blood cell that is needed to fight infection) in your blood. (medlineplus.gov)
  • You should not receive paclitaxel (with albumin) if you already have a low number of white blood cells. (medlineplus.gov)
  • without albumin, the high pressure in the blood vessels would force more fluids out into the tissues. (wikipedia.org)
  • Because smaller animals (for example rats) function at a lower blood pressure, they need less oncotic pressure to balance this[citation needed], and thus need less albumin to maintain proper fluid distribution. (wikipedia.org)
  • The general structure of albumin is characterized by several long α helices allowing it to maintain a relatively static shape, which is essential for regulating blood pressure. (wikipedia.org)
  • Blood plasma fractionation Bovine serum albumin Chromatography in blood processing Human serum albumin Lactalbumin Ovalbumin Sugio S, Kashima A, Mochizuki S, Noda M, Kobayashi K (June 1999). (wikipedia.org)
  • You should not receive albumin if you have severe anemia (lack of red blood cells), or severe heart failure. (rexhealth.com)
  • Medicinal albumin is made of plasma proteins from human blood. (rexhealth.com)
  • This medicine works by increasing plasma volume or levels of albumin in the blood. (rexhealth.com)
  • Albumin is used to replace blood volume loss resulting from trauma such as a severe burns or an injury that causes blood loss. (rexhealth.com)
  • Albumin is made from human plasma (part of the blood) which may contain viruses and other infectious agents. (rexhealth.com)
  • Your breathing, pulse, blood pressure, electrolyte levels, kidney function, and other vital signs will be watched closely while you are receiving albumin. (rexhealth.com)
  • The degree of permeability of the blood-brain barrier can be evaluated by the quantitative measurements of albumin in the CSF and the serum on specimens obtained at the same time. (labcorp.com)
  • In CSF that is free of blood contamination, therefore, albumin must necessarily have come from plasma through the blood-brain barrier. (labcorp.com)
  • If your physician suspects you might not have enough albumin in your body, he can perform a blood test to determine your range and recommend treatments to correct albumin levels. (livestrong.com)
  • To maintain normal blood albumin ranges, you should have between 3.4 and 5.4 g/dL of albumin in your blood. (livestrong.com)
  • The albumin in your blood moves the mineral calcium, the hormone progesterone and medicines throughout your tissues. (livestrong.com)
  • 16 The two main indications for the use of AlbuRx ® 25, Albumin (Human) 25% solution are therefore a plasma or blood volume deficit and the oncotic deficit resulting from hypoproteinemia. (nih.gov)
  • In such circumstances, the use of albumin infusion may be required to support the blood volume. (nih.gov)
  • Two classes of proteins are found in the blood, albumin and globulin. (labtestsonline.org)
  • Albumin is normally found in the blood and filtered by the kidneys. (cigna.com)
  • With MARS, toxic substances in the blood bind to the albumin, cross into the dialysis solution and are therefore removed from the body. (eurekalert.org)
  • Basically, this means that albumin is highly responsible for keeping water inside of blood vessels. (livestrong.com)
  • The neurotoxicity of albumin could be of importance in disease states which are accompanied by leakiness of the blood-brain barrier. (nih.gov)
  • However, one blood test for albumin about 10 days after surgery was a little low (3.0g/dL) but I had been suffering from diarrhea for a week from the cephalosporin antibiotics they were pumping into me and I didn't get any food to eat for approx. (rutgers.edu)
  • The serum albumin test looks at the levels of albumin in a person's blood. (medicalnewstoday.com)
  • Albumin is one of the most abundant proteins found in the blood. (medicalnewstoday.com)
  • A doctor will order a blood test, which will include a serum albumin element. (medicalnewstoday.com)
  • Typically, the range for albumin in the blood is between 3.4 to 5.4 grams per deciliter. (medicalnewstoday.com)
  • The serum albumin test requires only a small amount of blood. (medicalnewstoday.com)
  • BUMINATE 5%, Albumin (Human), 5% Solution contains no blood group isoagglutinins thereby permitting its administration without regard to the recipient 's blood group. (rxlist.com)
  • Because albumin is a relatively rare and expensive blood product, we asked if albumin had an advantage over other fluids to treat IDH. (cochrane.org)
  • All the proteins of the albumin family are water- soluble , moderately soluble in concentrated salt solutions, and experience heat denaturation . (wikipedia.org)
  • Serum albumin test: Why is it done and what do the results mean? (medicalnewstoday.com)
  • What does a serum albumin test tell you? (medicalnewstoday.com)
  • A doctor will often request a serum albumin test as part of a metabolic panel. (medicalnewstoday.com)
  • A doctor may use the serum albumin test in other cases to monitor existing conditions, such as kidney disease or chronic pancreatitis . (medicalnewstoday.com)
  • A serum albumin test does not usually require people to fast. (medicalnewstoday.com)
  • Since the serum albumin test is often one of several tests administered at any one time, a doctor will interpret all the results together to determine if any underlying conditions exist. (medicalnewstoday.com)
  • Can Nutrition Increase Albumin Levels? (livestrong.com)
  • Historically, albumin has been used as a marker of nutritional status, so often nutritional supplements would be prescribed to help increase albumin levels. (livestrong.com)
  • Older studies in septic patients, however, did not show any benefit of albumin over saline solution. (clinicaltrials.gov)
  • Solutions of rat albumin (3, 10 and 30 mg/ml) essentially free of fatty acids and globulins were injected into one neostriatum, physiological saline into the other. (nih.gov)
  • Thus 3, 10 and 30 mg/ml albumin produced lesions in excess of saline of 22 +/- 24 microns3, 67 +/- 25 microns3 and 170 +/- 44 microns3, (P = 0.82, 0.03 and 0.0005, respectively). (nih.gov)
  • Injection of 10 mg/ml albumin together with 10 mM sodium glutamate caused lesions of 70 +/- 11 microns3 in excess of saline (P = 0.005). (nih.gov)
  • This bottle contains 12.5 g albumin from venous plasma in saline and is osmotically equivalent to an equal volume of normal human plasma. (rxlist.com)
  • These can include saline, albumin or other fluids such as gelatins and starches. (cochrane.org)
  • This trial showed no difference between albumin and normal saline in all outcomes except for the amount of additional saline given, which was less in the group treated with albumin. (cochrane.org)
  • Results from 45 assessable participants did not lead to rejection of the null hypothesis of no difference between 5% albumin and normal saline in the primary outcome measure of percentage target ultrafiltration achieved, nor in 11/12 secondary outcomes. (cochrane.org)
  • Additional ( unblinded ) saline was given less often when 5% albumin was used compared with saline (16% versus 36%, P = 0.04). (cochrane.org)
  • Albumin Antibody in. (bmj.com)
  • The fluorescent immunoassay is a non-competitive, double-antibody method for the determination of human albumin in urine. (cdc.gov)
  • Antibody to human albumin is covalently attached to derivatized polyacrylamide beads. (cdc.gov)
  • Occasionally albumin appears in the urine of normal persons following long periods of standing (postural albuminuria). (wikipedia.org)
  • Microalbuminuria" is slowly being replaced with the term "albuminuria," which refers to any elevation of albumin in the urine. (labtestsonline.org)
  • For the specific albumins found in vertebrate bloodstreams, see serum albumin . (wikipedia.org)
  • Drinking too much water (water intoxication) may also cause abnormal albumin results. (medlineplus.gov)
  • If the amount of albumin is very small, but still abnormal, it is called microalbuminuria. (cigna.com)
  • People are at a higher risk for abnormal levels of albumin if they have an open wound or burn or following surgery. (medicalnewstoday.com)
  • 2018. "Adsorption of Bovine Serum Albumin on Carbon-Based Materials. (mdpi.com)
  • When the kidneys are working as they should, there may be a very small amount of albumin in the urine. (cigna.com)
  • This is because the amount of albumin can change, depending on how much water is in your urine. (cigna.com)
  • The presence of a small amount of albumin in the urine may be an early indicator of kidney disease. (labtestsonline.org)
  • A small amount of albumin in the urine is sometimes referred to as urine microalbumin or microalbuminuria. (labtestsonline.org)
  • With the aid of infrared spectroscopy the group is now able to demonstrate how the structure of albumin changes when exposed to heat. (medindia.net)
  • Another option worked on over recent years has been the production of albumin from vegetables, always using nuclear transformation. (scienceblog.com)
  • A property highly valued by the experts has to be added to these positive results: the production of albumin from plants using this technique does not involve the escape of genes through pollen transmission given that, with most crops under cultivation, the genome of the plastids is inherited maternally. (scienceblog.com)
  • Since the oncotic pressure of AlbuRx ® 25, Albumin (Human) 25% solution is about four times higher than that of normal human serum, it will expand the plasma volume if interstitial water is available for an inflow through the capillary walls. (nih.gov)
  • Albumin synthesis is increased at the level of mRNA synthesis in response to decreased serum oncotic pressure. (nih.gov)
  • In addition to being the major transport vessel for various hormones, enzymes, minerals, fatty acids and other metabolites, the main function of albumin is to maintain something known as oncotic pressure. (livestrong.com)
  • The four canonical human albumins are arranged on chromosome 4 region 4q13.3 in a tandem manner. (wikipedia.org)
  • If you do lose albumin in your body, the fluid can leak into your tissues and cause swelling. (livestrong.com)
  • Albumins are a group of acidic proteins which occur in the body fluids and tissues of mammals and in some plant seeds. (thomassci.com)
  • 96%, white lyophilized powder Synonyms: BSA, Bovine albumin Albumins are a group of acidic proteins which occur plentifully in the body fluids and tissues of mammals and in some plant seeds. (thomassci.com)
  • High albumin ( hyperalbuminemia ) is almost always caused by dehydration. (wikipedia.org)
  • Abstract We will evaluate four photoactivatable fatty acid analogs and three photoactivatable C16 alkylchain derivatives for their ability to derivatize to four representative biomaterials and subsequently adsorbhuman albumin. (sbir.gov)
  • Your doctor will order certain tests to check your body's response to paclitaxel (with albumin) injection. (medlineplus.gov)
  • Talk to your doctor about the risks of receiving paclitaxel (with albumin) injection. (medlineplus.gov)
  • Paclitaxel (with albumin) injection is used to treat breast cancer that has spread to other parts of the body and has not improved or worsened after treatment with other medications. (medlineplus.gov)
  • Paclitaxel (with albumin) injection is also used in combination with other chemotherapy medications to treat non-small cell lung cancer (NSCLC). (medlineplus.gov)
  • Paclitaxel (with albumin) injection is used in combination with gemcitabine (Gemzar) to treat cancer of the pancreas. (medlineplus.gov)
  • Paclitaxel (with albumin) injection comes as a powder to be mixed with liquid to be injected over 30 minutes intravenously (into a vein) by a doctor or nurse in a medical facility. (medlineplus.gov)
  • When paclitaxel (with albumin) injection is used to treat breast cancer, it is usually given once every 3 weeks. (medlineplus.gov)
  • When paclitaxel (with albumin) injection is used to treat non-small cell lung cancer it is usually given on days 1, 8, and 15 as part of a 3 week cycle. (medlineplus.gov)
  • Albumin human 25% solution for injection vial or plastic bag 50ml. (thefreedictionary.com)
  • A primed-constant infusion of a stable isotopic tracer of phenylalanine was used to determine hepatic fractional synthetic rate (FSR) and absolute synthetic rate (ASR) of albumin from the enrichment of phenylalanine in albumin. (nih.gov)
  • Albumin infusion in patients undergoing large-volume paracentesis: a meta-analysis of randomized trials. (medicin.dk)
  • Kidney disease-one of the many functions of the kidneys is to conserve plasma proteins such as albumin so that they are not released along with waste products when urine is produced. (labcorp.com)
  • Albumin in the urine usually denotes the presence of kidney disease. (wikipedia.org)
  • When the kidneys spill albumin, it can mean serious kidney damage is present. (cigna.com)
  • Like albumin, IgG is lost in the urine, its serum concentration is decreased, and the fractional rate of its catabolism is increased, suggesting that the kidney contributes to IgG catabolism in the presence of proteinuria. (nih.gov)
  • However, albumin may be detected in the urine even in the early stages of kidney disease . (labtestsonline.org)
  • This concept will change the understanding of several aspects of chronic kidney disease and will potentially help to stratify patients into different groups at risk according to their endotoxin status, and their immune and albumin dysfunction. (clinicaltrials.gov)
  • My 15 year old's results: albumin 4.71 globulin 2.23 a/g ratio 2.11 bilirubin total. (medhelp.org)
  • The binding properties of albumin may provide an indication for its use in severe hemolytic disease of the newborn, where it may lower the plasma concentration of free bilirubin pending an exchange transfusion. (nih.gov)
  • W.J. Cashore, W. Oh, and R. Brodersen, Reserve albumin and bilirubin toxicity index in infant serum, Acta Pædiatr. (springer.com)
  • F. Ebbesen, Effect of exchange transfusion on serum reserve albumin for binding of bilirubin and index of serum bilirubin toxicity, Acta Pædiatr. (springer.com)
  • F. Ebbesen, The relationship between serum bilirubin and reserve albumin for binding of bilirubin during phototherapy of preterm infants, Acta Pædiatr. (springer.com)
  • F. Ebbesen, Bilirubin, reserve albumin for binding of bilirubin and pH in plasma during phototherapy (ordinary and double light) of term newborn infants, Acta Pædiatr. (springer.com)
  • Agricultural engineer, Alicia Fernández San Millán, has developed a novel technique in Spain - plastidial transformation, in order to produce, in a recombinant form, human albumin from tobacco plants. (scienceblog.com)
  • Please inquire about custom formulations with Recombinant Albumin, which can be utilized in vaccine development. (neb.com)
  • Recombinant Albumin, Molecular Biology Grade, is a non-bovine derived albumin that can serve as an alternative to Bovine Serum Albumin (BSA). (neb.com)
  • Choose Recombinant Albumin, when there is a need to avoid BSA. (neb.com)
  • Equivalent stability performance between BSA and Recombinant Albumin. (neb.com)
  • BSA and Recombinant Albumin are used to stabilize enzymes in a reaction. (neb.com)
  • NcoI-HF ( NEB #R3193 ) was formulated with either BSA, Molecular Biology Grade or Recombinant Albumin and then stored at -20°C for 2 years. (neb.com)
  • The data shows equivalency between enzyme formulated with BSA, Molecular Biology Grade and Recombinant Albumin. (neb.com)
  • Recombinant Albumin that can serve as an alternative to BSA, which can prevent adhesion of enzymes to reaction tubes and pipette surfaces as well as stabilizes some proteins during incubation. (neb.com)
  • Please inquire about custom formulations with Recombinant Albumin. (neb.com)
  • However, since albumin levels respond to a variety of conditions in addition to malnutrition, a decrease in albumin needs to be evaluated carefully. (labcorp.com)
  • If he finds that you have low albumin due to malnutrition, adequate nutrition will be integral in getting your body back to health. (livestrong.com)
  • The doctor is now claiming that one low albumin level on that one particular day indicated I was suffering from malnutrition and that is one of the reasons my surgery failed. (rutgers.edu)
  • Albumin plays a major role in maintaining fluid balance in your body. (livestrong.com)
  • In addition to its role in maintaining fluid balance, albumin also acts as a transport vessel. (livestrong.com)
  • Increased albumin content and reduced free water clearance contribute to a retention of fluid within the circulation after intense exercise. (nih.gov)
  • A remarkable change occurs when many albumins are boiled with water, or treated with certain acids, their solubility and general characters being entirely altered, and the fluid becoming coagulated. (wikisource.org)
  • The use of this ratio allows the albumin concentration to be related to the dilution of urine (as indicated by the creatinine concentration) which can depend on how much fluid you have consumed that day. (labtestsonline.org.uk)
  • Albumin maintains the fluid balance in the body. (medicalnewstoday.com)
  • Substances containing albumins, such as egg white , are called albuminoids . (wikipedia.org)
  • Substances containing albumins are called albuminoids. (wikipedia.org)
  • The vegetable kingdom is the original source of albuminous substances, the albumins being found in greatest quantity in the seed. (wikisource.org)
  • However, if a person's kidneys become damaged or diseased, they begin to lose their ability to conserve albumin and other proteins. (labcorp.com)
  • Urinary albumin and urinary creatinine are measured in a random urine collected in the MEC. (cdc.gov)
  • Urinary albumin and urinary creatinine are measured in a random urine collected in the MEC (first collection) and a first morning void urine collected by the participant at home (second collection). (cdc.gov)
  • Therefore, measurement of urinary albumin and creatinine concentrations are performed and an albumin:creatinine ratio (ACR) was determined from both a random urine and a first morning void. (cdc.gov)
  • ACR measurement in random urine samples has been shown to be just as good as the measurement of albumin alone in 24 hour urine samples and is much more convenient for the person being tested. (labtestsonline.org.uk)
  • This property of creatinine allows its measurement to be used to correct for urine concentration when measuring albumin in a random urine sample. (labtestsonline.org)
  • When the hypovolemia is long-standing and hypoalbuminemia exists accompanied by adequate hydration or edema, treatment with BUMINATE 25%, Albumin (Human), 25% Solution is preferable. (rxlist.com)
  • Hypoalbuminemia is another possible indication for use of BUMINATE 5%, Albumin (Human), 5% Solution. (rxlist.com)
  • Occasionally hypoalbuminemia accompanying severe injuries, infections or severe pancreatitis cannot be quickly reversed and nutritional supplements may fail to restore adequate plasma albumin levels. (rxlist.com)
  • tell your doctor and pharmacist if you are allergic to paclitaxel, docetaxel, any other medications, or human albumin, Ask your doctor or pharmacist if you do not know if a medication that you are allergic to contains human albumin. (medlineplus.gov)
  • This page contains brief information about paclitaxel albumin-stabilized nanoparticle formulation and a collection of links to more information about the use of this drug, research results, and ongoing clinical trials. (cancer.gov)
  • Paclitaxel albumin-stabilized nanoparticle formulation is also being studied in the treatment of other types of cancer . (cancer.gov)
  • For more information about paclitaxel that may apply to paclitaxel albumin-stabilized nanoparticle formulation, see the Drug Information Summary for Paclitaxel . (cancer.gov)
  • Find Clinical Trials for Paclitaxel Albumin-stabilized Nanoparticle Formulation - Check for trials from NCI's list of cancer clinical trials now accepting patients. (cancer.gov)
  • The clinical trials on this list are studying Paclitaxel Albumin-Stabilized Nanoparticle Formulation. (cancer.gov)
  • When serum albumin levels decrease, the water in the plasma seeps into the empty space surrounding the cells where water doesn't usually collect, leading to swelling. (livestrong.com)
  • Another important impact of HSA oxidation is the decrease of its binding capacity leading to impaired detoxification ability of albumin. (clinicaltrials.gov)
  • Fatty Acid Free, ≥98%, Off-white Powder, sometimes with greenish hue Albumin bovine fraction V is the only commercially available Bovine Serum Albumin that is essentially fatty acid free. (thomassci.com)
  • Urinary albumin and creatinine are measured. (cdc.gov)