Albendazole: A benzimidazole broad-spectrum anthelmintic structurally related to MEBENDAZOLE that is effective against many diseases. (From Martindale, The Extra Pharmacopoeia, 30th ed, p38)Anthelmintics: Agents destructive to parasitic worms. They are used therapeutically in the treatment of HELMINTHIASIS in man and animal.Anticestodal Agents: Agents used to treat tapeworm infestations in man or animals.Mebendazole: A benzimidazole that acts by interfering with CARBOHYDRATE METABOLISM and inhibiting polymerization of MICROTUBULES.Echinococcosis: An infection caused by the infestation of the larval form of tapeworms of the genus Echinococcus. The liver, lungs, and kidney are the most common areas of infestation.Ivermectin: A mixture of mostly avermectin H2B1a (RN 71827-03-7) with some avermectin H2B1b (RN 70209-81-3), which are macrolides from STREPTOMYCES avermitilis. It binds glutamate-gated chloride channel to cause increased permeability and hyperpolarization of nerve and muscle cells. It also interacts with other CHLORIDE CHANNELS. It is a broad spectrum antiparasitic that is active against microfilariae of ONCHOCERCA VOLVULUS but not the adult form.Diethylcarbamazine: An anthelmintic used primarily as the citrate in the treatment of filariasis, particularly infestations with Wucheria bancrofti or Loa loa.Echinococcus: A genus of very small TAPEWORMS, in the family Taeniidae. The adult form is found in various CARNIVORA but not humans. The larval form is seen in humans under certain epidemiologic circumstances.Echinococcosis, Hepatic: Liver disease caused by infections with parasitic tapeworms of the genus ECHINOCOCCUS, such as Echinococcus granulosus or Echinococcus multilocularis. Ingested Echinococcus ova burrow into the intestinal mucosa. The larval migration to the liver via the PORTAL VEIN leads to watery vesicles (HYDATID CYST).Filaricides: Pharmacological agents destructive to nematodes in the superfamily Filarioidea.Praziquantel: An anthelmintic used in most schistosome and many cestode infestations.Ascariasis: Infection by nematodes of the genus ASCARIS. Ingestion of infective eggs causes diarrhea and pneumonitis. Its distribution is more prevalent in areas of poor sanitation and where human feces are used for fertilizer.Echinococcus granulosus: A species of hydatid tapeworm (class CESTODA) in the family Taeniidae, whose adult form infects the DIGESTIVE TRACT of DOGS, other canines, and CATS. The larval form infects SHEEP; PIGS; HORSES; and may infect humans, where it migrates to various organs and forms permanent HYDATID CYSTS.Trichuriasis: Infection with nematodes of the genus TRICHURIS, formerly called Trichocephalus.Ascaris lumbricoides: A species of parasitic nematode that is the largest found in the human intestine. Its distribution is worldwide, but it is more prevalent in areas of poor sanitation. Human infection with A. lumbricoides is acquired by swallowing fully embryonated eggs from contaminated soil.Elephantiasis, Filarial: Parasitic infestation of the human lymphatic system by WUCHERERIA BANCROFTI or BRUGIA MALAYI. It is also called lymphatic filariasis.Helminthiasis: Infestation with parasitic worms of the helminth class.Antiparasitic Agents: Drugs used to treat or prevent parasitic infections.Antinematodal Agents: Substances used in the treatment or control of nematode infestations. They are used also in veterinary practice.Hookworm Infections: Infection of humans or animals with hookworms other than those caused by the genus Ancylostoma or Necator, for which the specific terms ANCYLOSTOMIASIS and NECATORIASIS are available.Trichuris: A genus of nematode worms comprising the whipworms.Fenbendazole: Antinematodal benzimidazole used in veterinary medicine.Neurocysticercosis: Infection of the brain, spinal cord, or perimeningeal structures with the larval forms of the genus TAENIA (primarily T. solium in humans). Lesions formed by the organism are referred to as cysticerci. The infection may be subacute or chronic, and the severity of symptoms depends on the severity of the host immune response and the location and number of lesions. SEIZURES represent the most common clinical manifestation although focal neurologic deficits may occur. (From Joynt, Clinical Neurology, 1998, Ch27, pp46-50)Wuchereria bancrofti: A white threadlike worm which causes elephantiasis, lymphangitis, and chyluria by interfering with the lymphatic circulation. The microfilaria are found in the circulating blood and are carried by mosquitoes.Encephalitozoonosis: Infection with FUNGI of the genus ENCEPHALITOZOON. Lesions commonly occur in the BRAIN and KIDNEY tubules. Other sites of infection in MAMMALS are the LIVER; ADRENAL GLANDS; OPTIC NERVES; RETINA; and MYOCARDIUM.Strongyloidiasis: Infection with nematodes of the genus STRONGYLOIDES. The presence of larvae may produce pneumonitis and the presence of adult worms in the intestine could lead to moderate to severe diarrhea.Strongylida: An order of nematodes of the subclass SECERNENTEA. Characteristics include an H-shaped excretory system with two subventral glands.Parasite Egg Count: Determination of parasite eggs in feces.Intestinal Diseases, Parasitic: Infections of the INTESTINES with PARASITES, commonly involving PARASITIC WORMS. Infections with roundworms (NEMATODE INFECTIONS) and tapeworms (CESTODE INFECTIONS) are also known as HELMINTHIASIS.Encephalitozoon: A genus of FUNGI originally considered a member of the class SPOROZOEA but now recognized as part of the class MICROSPOREA.Antiplatyhelmintic Agents: Agents used to treat cestode, trematode, or other flatworm infestations in man or animals.Taenia: A genus of large tapeworms.Echinococcosis, Pulmonary: Helminth infection of the lung caused by Echinococcus granulosus or Echinococcus multilocularis.Cysticercosis: Infection with CYSTICERCUS, the larval form of the various tapeworms of the genus Taenia (usually T. solium in man). In humans they penetrate the intestinal wall and invade subcutaneous tissue, brain, eye, muscle, heart, liver, lung, and peritoneum. Brain involvement results in NEUROCYSTICERCOSIS.Strongyloides stercoralis: A species of parasitic nematode widely distributed in tropical and subtropical countries. The females and their larvae inhabit the mucosa of the intestinal tract, where they cause ulceration and diarrhea.Helminths: Commonly known as parasitic worms, this group includes the ACANTHOCEPHALA; NEMATODA; and PLATYHELMINTHS. Some authors consider certain species of LEECHES that can become temporarily parasitic as helminths.Antiprotozoal Agents: Substances that are destructive to protozoans.Larva Migrans: Infections caused by nematode larvae which never develop into the adult stage and migrate through various body tissues. They commonly infect the skin, eyes, and viscera in man. Ancylostoma brasiliensis causes cutaneous larva migrans. Toxocara causes visceral larva migrans.Nematode Infections: Infections by nematodes, general or unspecified.Eye Infections, Parasitic: Mild to severe infections of the eye and its adjacent structures (adnexa) by adult or larval protozoan or metazoan parasites.Filariasis: Infections with nematodes of the superfamily FILARIOIDEA. The presence of living worms in the body is mainly asymptomatic but the death of adult worms leads to granulomatous inflammation and permanent fibrosis. Organisms of the genus Elaeophora infect wild elk and domestic sheep causing ischemic necrosis of the brain, blindness, and dermatosis of the face.Loiasis: A parasitic infection caused by the nematode Loa loa. The vector in the transmission of this infection is the horsefly (Tabanus) or the deerfly or mango fly (Chrysops). The larvae may be seen just beneath the skin or passing through the conjunctiva. Eye lesions are not uncommon. The disease is generally mild and painless.Microfilaria: The prelarval stage of Filarioidea in the blood and other tissues of mammals and birds. They are removed from these hosts by blood-sucking insects in which they metamorphose into mature larvae.Thiabendazole: 2-Substituted benzimidazole first introduced in 1962. It is active against a variety of nematodes and is the drug of choice for STRONGYLOIDIASIS. It has CENTRAL NERVOUS SYSTEM side effects and hepatototoxic potential. (From Smith and Reynard, Textbook of Pharmacology, 1992, p919)Taenia solium: Species of tapeworm in the genus TAENIA, that infects swine. It is acquired by humans through the ingestion of cured or undercooked pork.Skin Diseases, Parasitic: Skin diseases caused by ARTHROPODS; HELMINTHS; or other parasites.Angiostrongylus cantonensis: A species of parasitic nematodes distributed throughout the Pacific islands that infests the lungs of domestic rats. Human infection, caused by consumption of raw slugs and land snails, results in eosinophilic meningitis.Ancylostomatoidea: A superfamily of nematode parasitic hookworms consisting of four genera: ANCYLOSTOMA; NECATOR; Bunostomum; and Uncinaria. ANCYLOSTOMA and NECATOR occur in humans and other mammals. Bunostomum is common in ruminants and Uncinaria in wolves, foxes, and dogs.Encephalitozoon cuniculi: A species of parasitic FUNGI. This intracellular parasite is found in the BRAIN; HEART; and KIDNEYS of several MAMMALS. Transmission is probably by ingestion of the spores (SPORES, FUNGAL).Gnathostoma: A genus of parasitic nematodes that occurs in mammals including man. Infection in humans is either by larvae penetrating the skin or by ingestion of uncooked fish.Microsporida: An order of parasitic FUNGI found mostly in ARTHROPODS; FISHES; and in some VERTEBRATES including humans. It comprises two suborders: Pansporoblastina and APANSPOROBLASTINA.Antibodies, Helminth: Immunoglobulins produced in a response to HELMINTH ANTIGENS.Trichinellosis: An infection with TRICHINELLA. It is caused by eating raw or undercooked meat that is infected with larvae of nematode worms TRICHINELLA genus. All members of the TRICHINELLA genus can infect human in addition to TRICHINELLA SPIRALIS, the traditional etiological agent. It is distributed throughout much of the world and is re-emerging in some parts as a public health hazard and a food safety problem.Drug Therapy, Combination: Therapy with two or more separate preparations given for a combined effect.Strongylida Infections: Infections with nematodes of the order STRONGYLIDA.Feces: Excrement from the INTESTINES, containing unabsorbed solids, waste products, secretions, and BACTERIA of the DIGESTIVE SYSTEM.Strongyloides: A genus of parasitic nematodes widely distributed as intestinal parasites of mammals.Microsporidiosis: Infections with FUNGI of the phylum MICROSPORIDIA.Giardia lamblia: A species of parasitic EUKARYOTES that attaches itself to the intestinal mucosa and feeds on mucous secretions. The organism is roughly pear-shaped and motility is somewhat erratic, with a slow oscillation about the long axis.Central Nervous System Helminthiasis: Infections of the BRAIN; SPINAL CORD; or MENINGES caused by HELMINTHS (parasitic worms).
Persistent damage to Enterocytozoon bieneusi, with persistent symptomatic relief, after combined furazolidone and albendazole in AIDS patients. (1/555)AIM: To investigate morphological changes in Enterocytozoon bieneusi and the duration of symptomatic relief after combination treatment with furazolidone and albendazole in AIDS patients. METHODS: Four severely immunocompromised AIDS patients with symptomatic E bieneusi infection of the gut received an 18 day course of combined furazolidone and albendazole (500 + 800 mg daily). All patients were monitored for parasite shedding in stool by light microscopy at the end of treatment and monthly during follow up. At the end of treatment, duodenal biopsy specimens obtained from three patients were studied by transmission electron microscopy by two pathologists blind to the patients' treatment or clinical outcome. Duodenal biopsy specimens obtained from one of the patients two months after completion of treatment were also studied electronmicroscopically. RESULTS: All patients had long lasting symptomatic relief, with a major decrease--or transient absence--of spore shedding in stools from completion of treatment. After treatment, changes in faecal spores were persistently found by light microscopy in all cases, and there was evidence of both a substantial decrease in the parasite load and ultrastructural damage in the parasite in all biopsy specimens. The treatment was well tolerated, and no patient had clinical or parasitological relapse during follow up (up to 15 months). CONCLUSIONS: The long lasting symptomatic relief observed in all four treated patients correlated with the persistent decrease in parasite load both in tissue and in stool, and with the morphological changes observed in the life cycle of the protozoan. These data suggest that combined treatment with furazolidone and albendazole is active against E bieneusi and may result in lasting remission even in severely immunocompromised patients. (+info)
Double-blind placebo-controlled study of concurrent administration of albendazole and praziquantel in schoolchildren with schistosomiasis and geohelminths. (2/555)A double-blind placebo-controlled study of the concurrent administration of albendazole and praziquantel was conducted in>1500 children with high prevalences of geohelminths and schistosomiasis. The study sites were in China and the Philippines, including 2 strains of Schistosoma japonicum, and 2 different regions of Kenya, 1 each with endemic Schistosoma mansoni or Schistosoma haematobium. Neither medication affected the cure rate of the other. There was no difference between the side effect rate from albendazole or the double placebo. Praziquantel-treated children had more nausea, abdominal pain, and headache but these side effects were statistically more common in children with schistosomiasis, suggesting a strong influence of dying parasites. The subjects were followed for 6 months for changes in infection status, growth parameters, hemoglobin, and schistosomiasis morbidity. In all 4 sites, a significant 6-month increase in serum hemoglobin was observed in children who received praziquantel, strongly supporting population-based mass treatment. (+info)
Neurocysticercosis in an Italian traveler to Latin America. (3/555)Neurocysticercosis is rarely reported in short-term travelers, although the disease remains a major public health problem in tropical regions. We present a case of neurocysticercosis that was probably acquired by ingestion of Taenia solium eggs contained in the stomach of a pig butchered by the traveler. Complete clinical resolution was obtained by medical treatment, underlying the importance of early suspicion and diagnosis of the disease. (+info)
The cost effectiveness of strategies for the treatment of intestinal parasites in immigrants. (4/555)BACKGROUND: Currently, more than 600,000 immigrants enter the United States each year from countries where intestinal parasites are endemic. At entry persons with parasitic infections may be asymptomatic, and stool examinations are not a sensitive method of screening for parasitosis. Albendazole is a new, broad-spectrum antiparasitic drug, which was approved recently by the Food and Drug Administration. International trials have shown albendazole to be safe and effective in eradicating many parasites. In the United States there is now disagreement about whether to screen all immigrants for parasites, treat all immigrants presumptively, or do nothing unless they have symptoms. METHODS: We compared the costs and benefits of no preventive intervention (watchful waiting) with those of universal screening or presumptive treatment with 400 mg of albendazole per day for five days. Those at risk were defined as immigrants to the United States from Asia, the Middle East, sub-Saharan Africa, Eastern Europe, and Latin America and the Caribbean. Cost effectiveness was expressed both in terms of the cost of treatment per disability-adjusted life-year (DALY) averted (one DALY is defined as the loss of one year of healthy life to disease) and in terms of the cost per hospitalization averted. RESULTS: As compared with watchful waiting, presumptive treatment of all immigrants at risk for parasitosis would avert at least 870 DALYs, prevent at least 33 deaths and 374 hospitalizations, and save at least $4.2 million per year. As compared with watchful waiting, screening would cost $159,236 per DALY averted. CONCLUSIONS: Presumptive administration of albendazole to all immigrants at risk for parasitosis would save lives and money. Universal screening, with treatment of persons with positive stool examinations, would save lives but is less cost effective than presumptive treatment. (+info)
Serum cytokine detection in the clinical follow up of patients with cystic echinococcosis. (5/555)The relation of serum cytokine levels and outcome of chemotherapy was evaluated in 15 patients with cystic echinococcosis. Serum IL-4, IL-10 and interferon-gamma (IFN-gamma) concentrations were determined by ELISA before and after a 3-month course of albendazole treatment: at least one serum sample per patient from 13 patients (87%) contained measurable amounts of IL-4; samples from five patients (33%) measurable amounts of IL-10 and samples from only two patients (13%) measurable amounts of IFN-gamma. Clinical assessment at 1 year after the end of therapy showed that 11 of the 15 patients had responded clinically. Seven of these patients had lower IL-4 serum concentrations, two had unchanged and two undetectable amounts (pre- versus post-therapy, n = 11, P = 0.008). Conversely, of the patients who did not respond, three had higher and one patient unchanged serum IL-4 concentrations. Serum IL-10 10 levels also decreased in all patients who responded (3/5) and increased in all patients who did not (2/5). No association was found between cytokine concentrations and cyst characteristics or antibody levels. Overall these data suggest that serum IL-4 detection may be useful in the follow up of patients with cystic echinococcosis. (+info)
Efficacies of albendazole sulfoxide and albendazole sulfone against In vitro-cultivated Echinococcus multilocularis metacestodes. (6/555)The metacestode stage of Echinococcus multilocularis is the causative agent of alveolar echinococcosis (AE), a parasitic disease affecting the liver, with occasional metastasis into other organs. Benzimidazole carbamate derivatives such as mebendazole and albendazole are currently used for chemotherapeutic treatment of AE. Albendazole is poorly resorbed and is metabolically converted to its main metabolite albendazole sulfoxide, which is believed to be the active component, and further to albendazole sulfone. Chemotherapy with albendazole has been shown to have a parasitostatic rather than a parasitocidal effect; it is not effective in all cases, and the recurrence rate is rather high once chemotherapy is stopped. Thus, development of new means of chemotherapy of AE is needed. This could include modifications of benzimidazoles and elucidiation of the respective biological pathways. In this study we performed in vitro drug treatment of E. multilocularis metacestodes with albendazole sulfoxide and albendazole sulfone. High-performance liquid chromatography analysis of vesicle fluids showed that the drugs were taken up rapidly by the parasite. Transmission electron microscopic investigation of parasite tissues and nuclear magnetic resonance spectroscopy of vesicle fluids demonstrated that albendazole sulfoxide and albendazole sulfone had similar effects with respect to parasite ultrastructure and changes in metabolites in vesicle fluids. This study shows that the in vitro cultivation model presented here provides an ideal first-round test system for screening of antiparasite drugs. (+info)
Cost of school-based drug treatment in Tanzania. The Partnership for Child Development. (7/555)It has been argued that targeting delivery of anthelmintics to school-children by taking advantage of the existing education infrastructure and administrative system can be one of the most cost-effective approaches in minimizing the intensity of infections with both schistosomiasis and major intestinal nematodes in many developing countries. The study was conducted in January 1997, shortly after the completion of the drug intervention programme. This paper provides an analysis of the costs of providing age-targeted treatment of school-children for urinary schistosomiasis using praziquantel and for intestinal nematodes using albendazole as an integral part of the School Health Programme in Tanga Region, Tanzania. The analysis shows that the total financial cost of the intervention programme in 1996 prices was US$54 252.28 (exchange rate: TSH 573 = US$1). Of this amount, the cost of drugs constitutes 80.6%, while the delivery cost appears relatively low, representing just below 20%. Even when the opportunity cost of unpaid days of labour input is included, the cost of drugs still remains the highest cost component of the intervention (55.8%). In the current epidemiological and logistic setting of Tanzania, the financial cost per child treated using praziquantel, which involved prior screening at the school level, was US$0.79, while treatment using albendazole was as low as US$0.23, of which US$0.20 was drug purchase cost. It is concluded that the base cost of delivering a universal, standard, school-based health intervention such as albendazole can be as low as US$0.03 per child tested, but even a very slight increase in the complexity of delivery can have a very significant impact on the cost of intervention. (+info)
Evidence for an improvement in cognitive function following treatment of Schistosoma japonicum infection in Chinese primary schoolchildren. (8/555)A double-blind, placebo-controlled, treatment trial was conducted in Sichuan, China to investigate the unique and combined effects on the cognitive function (working memory) of children after treating geohelminth infections with albendazole and treating Schistosoma japonicum infection with praziquantel. One hundred eighty-one children 5-16 years of age participated. At baseline, the praziquantel and placebo groups were similar in all background characteristics. Three months after praziquantel treatment, there was a significant reduction in the prevalence and intensity of S. japonicum infection. There were significant age group by praziquantel treatment interaction effects in three of the five cognitive tests, Fluency, Picture Search, and Free Recall, with effects being strongest in the youngest children (5-7 years old). Exploratory analysis within the youngest children showed a significant positive main effect of treatment on Fluency (P < 0.001), after controlling for sex, anthropometric, and parasitic and iron status. There was also a treatment by height-for-age interaction (P = 0.03) and a treatment by iron status interaction (P = 0.024) on Fluency. There was a treatment by S. japonicum intensity interaction (P < 0.001) on Free Recall, but the main effect of treatment on Picture Search was not significant (P = 0.058). Younger children and those who are physically the most vulnerable are likely to benefit the most from the treatment of S. japonicum infection in terms of improved performance on tests of working memory. (+info)
While albendazole is the preferred drug, mebendazole can also be used if the treatment is to be for an extended period of time ... An alternative to albendazole is mebendazole for at least 3 to 6 months. The other alternative to surgery is PAIR with ... The medication used is albendazole, which may be needed for years. The alveolar disease may result in death. The disease occurs ... Patients who undergo PAIR typically take albendazole or mebendazole from 7 days before the procedure until 28 days after the ...
Other drugs that are effective are albendazole and thiabendazole (25 mg/kg twice daily for 5 days-400 mg maximum (generally)). ...
Albendazole is given at a single dose. WHO recommends annual treatment in areas where between 20 and 50% of people are infected ... For this purpose, broad-spectrum benzimidazoles such as mebendazole and albendazole are the drugs of choice recommended by WHO ... The World Health Organizations recommended albendazole or mebendazole for treatment. One strategy to control the disease in ... However, it has been reported that albendazole, mebendazole, and pyrantel pamoate are not entirely effective against T. ...
For example, the treatment of choice for soil-transmitted helminths is mebendazole and albendazole and praziquantel for ... Benzimidazoles: Albendazole - effective against threadworms, roundworms, whipworms, tapeworms, hookworms Mebendazole - ...
In enzymology, an albendazole monooxygenase (EC 184.108.40.206) is an enzyme that catalyzes the chemical reaction albendazole + ... H2O The four substrates of this enzyme are albendazole, NADPH, H+, and O2, whereas its three products are albendazole S-oxide, ... Other names in common use include albendazole oxidase, and albendazole sulfoxidase. It employs one cofactor, FAD. "Showing ... Enzyme 220.127.116.11 at KEGG Fargetton X, Galtier P, Delatour P (1986). "Sulfoxidation of albendazole by a cytochrome P450- ...
DMOZ - Health: Pharmacy: Drugs and Medications: A: Albendazole
Consumer information regarding drug use, side effects, interactions and pill identification. ...
Another agent used is albendazole. "Microsporidiosis: Parasitic Infections: Merck Manual Home Health Handbook". ...
Pinworms are treated with albendazole. Vulvar Candida infections are uncommon in children, and generally occur in infants after ...
Albendazole is also highly effective. Atrabine is quite effective but has adverse effects in humans. Taeniasis is predominantly ...
Reportedly, albendazole can also be effective. Another interesting potential diagnostic tool and treatment is the contrast ... Molodozhnikova NM, Volodin AV, Bakulina NG (Nov-Dec 1991). "[The action of albendazole on the broad tapeworm]". Meditsinskaia ...
Alternative agents include mebendazole and albendazole. Successful treatment with ivermectin has also been reported. Another ...
Albendazole is a common drug treatment. Sullivan, John (2011). A Color Atlas of Parasitology. pp. 150-151. ISBN 0-9665807-7-X. ...
Albendazole can be used as an alternative. A randomised-controlled trial published in 2011 showed that the broad-spectrum anti- ...
... although treatment with albendazole alone (avoiding surgery) has been reported to be successful. Intestinal perforation (an ... "Albendazole for the Treatment of Anisakiasis Ileus". Clinical Infectious Diseases. 41 (12): 1825-26. doi:10.1086/498309. PMID ...
Albendazole is very effective on the microfilariae. Hetrazan, tetramisole and levamisole are most commonly used. Anderson, R.C ... Nayak, A.; Gayen, P.; Saini, P.; Maitra, S.; Sinha Babu, S.P. (2011). "Albendazole induces apoptosis in adults and ...
Albendazole is not effective in treating this condition; praziquantel is the preferred agent. "Genus Bertiella Stiles & Hassall ...
The benzimidazole compounds albendazole (brand names e.g., Albenza, Eskazole, Zentel and Andazol) and mebendazole (brand names ... Treatment is typically with two doses of the medications mebendazole, pyrantel pamoate, or albendazole two weeks apart. ...
The effective dosage at which albendazole has been shown effective is 90 mg/kg twice a day for 21 straight days. On the other ... Maleewong W, Loahabhan P, Wongkham C, Intapan P, Morakote N, Khamboonruang C (1992). "Effects of albendazole on Gnathostoma ... Laboratory testing on mice treated once or twice daily with albendazole were shown to have a significant reduction in worm ...
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Albendazole in the Management of Extraocular Cysticercosis (Abst). Ophthalmology 1996 (S) : 175. 221. Vajpayee RB, Kasra T, ... Oral Albendazole in the management of extraocular cysticercosis. British Journal of Ophthalmology, 1994; 78:621-623. 229. Kumar ...
The US Protocol includes a single dose of albendazole. In many states, the domestic health screening exam recommends that all ... of intestinal parasites among newly arrived Southeast Asian and African refugees after empiric predeparture albendazole ...
Jitpimolmard, S (2007). "Albendazole therapy for eosinophilic meningitis caused by Angiostrongylus cantonensis". Parasitol Res ... Although early research did not show treatment with antihelminthic agents like thiobendazole or albendazole effective in ... Although combination therapy using albendazole and prednisolone has no significant advantage compared to treatment using ... Chotmongkol, V (2004). "Treatment of eosinophilic meningitis with a combination of albendazole and corticosteroid". Southeast ...
Ortiz JJ, Favennec L, Chegne NL, Gargala G (2002). "Comparative clinical studies of nitazoxanide, albendazole and praziquantel ... Single-dose albendazole (400 mg) is also very efficacious (>95%). A three-day course of nitazoxanide is 75-93 ...
In general cestode infections are treated with praziquantel and albendazole. Atrabine is quite effective but indicates adverse ...
Albendazole is also highly effective for treatment of cattle infection. Adequate cooking (56 °C for 5 minutes) of beef viscera ...
... can be treated with albendazole, mebendazole and benzimidazoles. Pyrantel pamoate is an alternative. In ...
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The current treatments against Trichuris trichiura, albendazole and mebendazole, are only poorly efficacious. Therefore, combination chemotherapy was recommended for treating soil-transmitted helminthiasis. Albendazole-mebendazole and albendazole-oxantel pamoate have shown promising results in clinical trials. However, in vitro and in vivo drug interaction studies should be performed before their simultaneous treatment can be recommended. Inhibition of human recombinant cytochromes P450 (CYPs) CYP1A2, CYP2C9, CYP2C19, CYP2D6, and CYP3A4 was tested by exposure to albendazole, albendazole sulfoxide, mebendazole, and oxantel pamoate, as well as albendazole-mebendazole, albendazole sulfoxide-mebendazole, albendazole-oxantel pamoate, and albendazole sulfoxide-oxantel pamoate. A high-pressure liquid chromatography (HPLC)-UV/visible spectroscopy method was developed and validated for simultaneous quantification of albendazole sulfoxide, albendazole sulfone, mebendazole, and oxantel pamoate in plasma. ...
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Therapeutic efficacy of different brands of albendazole against soil transmitted helminths among students of Mendera Elementary...
INTRODUCTION: different brands Albendazole are commercially available and the efficacious brand/s is/are required for effective control of STHs infection. Thus, this study is aimed at determining the therapeutic efficacy of different brands of albendazole against soil transmitted helminths among school children of Jimma town. METHODS: a cross sectional survey for prevalence of geohelminths and a randomized trial for efficacy study of different brands of albendazole was conducted among students Mendera Elementary School from March 29 to April 29, 2010. Positive subjects were randomized into three treatment arms using lottery method. The collected stool samples were examined by the McMaster method. CRs were calculated using SPSS windows version 16 and ERRs were calculated using appropriate formula. RESULTS: of the 715 school children who had their stools examined, 326 were positive for STHs with a prevalence rate of 45.6%. The cure rates (CR) for A. lumbricoides, T. trichiura and Hookworm were 99.4, 59.9
A Multinational Trial of the Efficacy of Albendazole Against Soil-transmitted Nematode Infections in Children - Tabular View -...
The three major Soil-Transmitted Helminths (STH), Ascaris lumbricoides, Necator americanus/Ancylostoma duodenal and Trichuris trichiura are among the most prevalent parasites worldwide. The objective of this multicentre international study is to define the efficacy of a single 400 milligram dose of albendazole (ALB) against these three STHs using a standardised protocol. The trial will be undertaken among school age children in seven countries - Brazil, Cameroon, Cambodia, Ethiopia, India, Tanzania (Zanzibar) and Vietnam - each with a different epidemiologic pattern of infection. A trial of this nature is urgently required because in spite of the wide usage of albendazole over the last 3 decades, there is still no key publication reporting the efficacy of the anthelmintic accurately, and to modern conventional standards, that can act as a central reference for the baseline efficacy. The latter is critically important because albendazole is now being used even more widely, as large scale mass ...
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The effect of different anthelmintic treatment regimens combined with iron supplementation on the nutritional status of...
A randomized controlled trial in KwaZulu-Natal (South Africa) of 428 primary-school pupils (stratified into 6 groups by age, sex and intervention) measured the effect of different anthelmintic treatments and iron supplementation regimens provided twice at 6-monthly intervals for 1 year (1996/97). Half the pupils received iron supplementation (ferrous fumarate 200 mg weekly for 10 weeks). Pupils received 2 anthelmintic regimens, either (i) albendazole 400 mg plus praziquantel 40 mg/kg or (ii) albendazole 400 mg on 3 consecutive days plus praziquantel 40 mg/kg or (iii) placebo. Baseline prevalences of Ascaris 55.9%, Trichuris 83.6%, hookworm spp. 59.4%, were reduced after 12 months for single-dose albendazole treatment to Ascaris 17.4% (P , 0.005), Trichuris 61.5% (NS), hookworm spp. 0% (P , 0.005), and for triple-dose albendazole treatment to Ascaris 14.8% (P , 0.005), Trichuris 25.0% (P , 0.01), hookworm 0% (P , 0.005). Schistosoma haematobium 43.4% was reduced among treated groups to 8.3% (P , ...
Effect of Albendazole Treatments on the Prevalence of Atopy in Children Living in Communities Endemic for Geohelminth Parasites...
Epidemiological studies have shown inverse associations between geohelminth (intestinal helminth) infection and atopy, leading to the suggestion that geohelminths might protect against allergy. Periodic deworming of school children with anthelmintics is a widely implemented intervention and has raised concerns that such programmes could increase allergy. We investigated the effect of repeated anthelmintic treatments with albendazole over 12 months on the prevalence of atopy and clinical indices of allergy. ...
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Material and Methods. Chemicals and reagents. DP and mono-N-depropyldisopyramide (MNDP) were kindly supplied by Laboratórios Silva Araújo Roussel Roussel UCLAF (Brazil). ABZ, albendazole sulfoxide (ASOX) and albendazole sulfone (ASON) were provided by Robert Young & Co. Ltd (Scotland, U.K.). Iodosylbenzene (PhIO) was synthesized according to a previously described method.12 The porphyrins H2(TDCPP) and H2(TNPP) (Figure 1) were purchased from Midcentury (USA) and iron insertion into the free base porphyrins was carried out according to the literature.13 The perchloration of [Fe(TNPP)] was carried out according to Wijesekera et al.14. Methanol and acetonitrile (EM Science, USA) were of HPLC grade. All other chemicals were analytical-reagent grade and were used without further purification. The water used for mobile phase preparation was purified with a Milli-Q Plus System (Millipore, USA).. Oxidation reactions. The reaction mixtures (2 mL) in dichloroethane contained 6.0 mmol L-1 DP or ABZ, 0.3 ...
The adverse effects of albendazole and praziquantel in mass drug administration by trained schoolteachers.
Eastern and Southern Africa Centre of International Parasite Control (ESACIPAC) conducted stool examinations for soil transmitted helminthiases (STH) and Schistosoma mansoni, among school children in Mwea Division, Central Kenya where both infections are endemic. Mass drug administrations (MDAs) were then conducted in 2004 and 2005 using schoolteachers trained on how to administer treatment, physically and psychologically prepare the children to take the medication, have them eat before treatment, handle minor and refer serious side eﬀects to local health facilities. Local health workers were on standby to help manage severe side eﬀects. This study examined side eﬀects of the drugs and the teachers preparedness to handle the children when such eﬀects occurred. No serious side eﬀects requiring referral to the health centre occurred and the minor ones observed were temporal. In 2005 children in Mwea schools were treated with albendazole 400mg and praziquantel 40mg/kg body weight while ...
Abstract Albendazole was administered preoperatively to two patients with active alveolar hydatid disease for 58 and 84 days. Vesicles of larval Echinococcus multilocularis obtained from surgical tissues were inoculated into red-backed voles for in vivo testing viability. No proliferation of the larval cestode had occurred when the animals were dissected three months post-inoculation. These findings suggest that short-term therapy with albendazole was effective in killing the larval cestode in these two cases. Albendazole was found to be hepatotoxic but resulting transaminase abnormalities have been reversible. Close monitoring of liver function and hematology is essential in patients under albendazole therapy.
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Chemotherapy plays a very important role not only in reducing patient morbidity and mortality but also in reducing transmission of the parasitic infection. Many of the drugs used to treat parasitic infections have serious side effects; therefore, before initiation of therapy, it is important to consider the following factors: health of the patient, parasite drug resistance, accuracy of the original dose, potential drug toxicity, and the need for follow-up examinations to monitor therapy. This chapter talks about antiparasitic drugs that include albendazole, amphotericin B, amphotericin B, artemether and benznidazole. The systemic anthelmintic activity has been attributed to the primary metabolite, albendazole sulfoxide. Patients being treated for neurocysticercosis should receive appropriate steroid and anticonvulsant therapy as required. Oral or intravenous corticosteroids should be considered to prevent cerebral hypertensive episodes during the first week of anticysticercal therapy. AmBisome treatment
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A Comparative Trial of a Single-Dose Ivermectin Versus Three Days of Albendazole for Treatment of Strongyloides Stercoralis and...
Abstract A randomized trial carried out in rural Zanzibar comparing a single dose of 200 µg/kg of ivermectin and 400 mg/day for three days of albendazole for treatment of strongyloidiasis and other intestinal nematodes is described. In 301 children with Strongyloides stercoralis infection, treatment with ivermectin or albendazole resulted in cure rates of 83% and 45%, respectively. While both drugs were very effective against Ascaris lumbricoides, Trichuris trichiura was cured only in 11% (ivermectin) and 43% (albendazole) of the subjects, although the mean eggload was reduced by 59% and 92%, respectively. Ivermectin was ineffective against hookworms, while albendazole resulted in a cure rate of 98%. No severe side effects were recorded and mild side effects were of transient nature for both treatments. Therefore, ivermectin provides a safe and highly effective single dose treatment for S. stercoralis and A. lumbricoides, while it is not an alternative for the treatment of T. trichiura and hookworm
HealthyMuslim.Com | Effects of Nigella Sativa and Albendazole Alone and in Combination in Toxocara Canis Infected Mice
OBJECTIVE: nigella sativa extract has been used in the Middle East as a traditional medicine for several complaints. We aimed to evaluate the biochemical, histopathological and hematologic changes in Toxocara canis-infected mice after treatment with nigella sativa extract, albendazole or a combination of both. METHODS: This comparative study was conducted between June and July 2008 at the Itarran University Saniturla Turkey. Sixty healthy adult BALB/c male mice were randomly divided into six groups (D0-D5). Mice in groups D1-D5 received 500 embryonated T. canis eggs via esophageal tube. Groups DO and D1 served as a non-infected sham group and an infected control group, respectively. Groups D2 and D3 received 100 and 200 mg/kg N. sativa extract (NSE), respectively. Group D4 received 100 mg/kg albendazole. Group D5 received the combination dose (100+100 mg/kg NSE+albendazole). RESULTS: Treatment with N. sativa of both doses or the combination dose of N. sativa and albendazole reduced the degree of ...
An unusual recurrence of pruritic creeping eruption after treatment of cutaneous larva migrans in an adult Ghanaian male: a...
The hookworm related Cutaneous Larva Migrans is a common disease present in the tropic and subtropical areas of the world. The disease is self limiting and would naturally resolve within weeks. However, an unusual recurrence of the disease in a Ghanaian male after standard treatment was observed and is herein reported. A 52 year old Ghanaian male of Akan dissent was diagnosed with Cutaneous Larva Migrans in a clinic in Accra, Ghana. Symptoms of the disease persisted for three days after treatment with a 400mg single dose Albendazole and was only resolved after re-dosing with 400mg daily of the same drug for three days. Two months post-treatment, the usual pruritic creeping eruption typical with the disease re-appeared even though the victim has not been re-exposed to any possible larva contaminated source. This could possibly be a case of hookworm- related larva resistance to a standard anti-helminthic therapy and host immunity.
Community-based trial of annual versus biannual single-dose ivermectin plus albendazole against Wuchereria bancrofti infection...
With the failure to interrupt the transmission of LF in some areas following the recommended years of MDA, alternative and effective MDA regimens and strategies are needed if the GPELF is to achieve the goals of global elimination. Simonsen and colleagues, therefore, recommended treatment to be given at shorter intervals - perhaps every 6 months . Further, a study reported that in villages which were hyperendemic for onchocerciasis, after some 14 years of biannual treatment with IVM, no Wuchereria bancrofti could be detected, while in adjacent villages a prevalence of around 3% was found . The elimination of onchocerciasis in some countries in the Americas has been attributed to the use of twice-yearly treatment regimens [11, 12]. Even though there are no studies that explicitly compare the effects of once yearly versus twice-yearly treatment in onchocerciasis control , this provides some evidence that biannual treatment may be effective in the control of LF in areas with persistent ...
Efficacy of 3 anthelmintics in communally grazed sheep as reflected by faecal egg count reduction tests in a semi-arid area of...
ABSTRACT. A survey was conducted on the occurrence of anthelmintic resistance of nematodes in communally grazed sheep in a semi-arid area near Mafikeng South Africa, from January to March 2006. In the herds belonging to twelve smallholder sheep farmers, the efficacies of albendazole, levamisole and closantel were tested by faecal egg count reduction tests where 80 % efficacy was considered the cut off for anthelmintic resistance. The results of the faecal egg count reduction tests showed more than 80 % efficacy with all the drugs used in most cases, but there were notable exceptions. In 1 case, closantel had an efficacy of 72%, albendazole had an efficacy of 68 % and levamisole showed efficacies of 58%, 60% and 75 =% respectively on 4 farms. The occurrence of anthelmintic resistance in this farming sector is of concern and steps should be taken to prevent its further spread and development to avoid a situation developing as on numerous commercial sheep farms in South Africa where resistance is ...
Fatal liver and lung alveolar echinococcosis with newly developed neurologic symptoms due to the brain involvement - Zurich...
The fox tapeworm Echinococcus multilocularis causes human alveolar echinococcosis, commonly affecting the liver. However, in ∼1% of cases, systematic spread of the disease involves the brain as well. A patient had a 6-year history of liver and lung alveolar echinococcosis that was considered not suitable for surgery, and treatment with albendazole was introduced. After the appearance of neurologic disturbances, an intracranial mass lesion was demonstrated by radiologic imaging. The lesion was surgically removed, and histologic analysis revealed metacestode tissue of E. multilocularis. Despite the surgical resection of the lesion, the patient died of progression of systemic alveolar echinococcosis. The authors highly recommend implementing neurologic monitoring to the follow-up algorithm for patients with systemically disseminated alveolar echinococcosis. When neurologic symptoms occur, radiologic imaging of the brain should be obtained immediately. Surgery should be considered for all ...
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BALB/c Mice Immunity to Hydatidosis Induced by In-vitro Reared Echinococcus granulosus Adult Worm Antigens
Background: Echinococcosis is a zoonotic parasitic disease caused by the larval stage of Echinococcus granulosus. Several native and recombinant antigens, derived from different stages of E. granulosus life cycle, have been used for vaccine trials. In vitro reared adult worms are good candidates for vaccination as they do not produce fertile egg/s and do not have any risk of contamination for researchers. Objective: To evaluate different antigens derived from in vitro reared E. granulosus adult worms for the immunization of BALB/c mice against secondary hydatidosis. Methods: Viable protoscoleces (PCSs) of sheep hydatid cyst were cultivated in S.10E.H media. Excretory secretory (E/S) and crude antigens were prepared from reared adult worms. A total of fifty BALB/c mice, each 8-weeks-old, were divided into 5 groups of 10 mice. Three groups were subcutaneously immunized with crude, E/S and immunodominant antigens on days 1 and 28. The fourth group received only PBS and the fifth group had no injection.
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