RNA, Transfer, Ala
RNA Ligase (ATP)
Polynucleotide Ligases
Polynucleotide 5'-Hydroxyl-Kinase
RNA, Transfer
The small RNA molecules, 73-80 nucleotides long, that function during translation (TRANSLATION, GENETIC) to align AMINO ACIDS at the RIBOSOMES in a sequence determined by the mRNA (RNA, MESSENGER). There are about 30 different transfer RNAs. Each recognizes a specific CODON set on the mRNA through its own ANTICODON and as aminoacyl tRNAs (RNA, TRANSFER, AMINO ACYL), each carries a specific amino acid to the ribosome to add to the elongating peptide chains.
Alanine
Base Sequence
Amino Acyl-tRNA Synthetases
RNA Splicing
Basic-Leucine Zipper Transcription Factors
Saccharomyces cerevisiae
tRNA Methyltransferases
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Escherichia coli
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.
Ubiquitin-Protein Ligases
A diverse class of enzymes that interact with UBIQUITIN-CONJUGATING ENZYMES and ubiquitination-specific protein substrates. Each member of this enzyme group has its own distinct specificity for a substrate and ubiquitin-conjugating enzyme. Ubiquitin-protein ligases exist as both monomeric proteins multiprotein complexes.
Amino Acid Sequence
Alanine Transaminase
Anticodon
DNA Ligases
Alanine Racemase
RNA, Transfer, Amino Acid-Specific
RNA, Transfer, Amino Acyl
RNA, Transfer, Ser
Nucleic Acid Conformation
Ubiquitination
RNA, Transfer, Phe
Ubiquitin-Protein Ligase Complexes
Complexes of enzymes that catalyze the covalent attachment of UBIQUITIN to other proteins by forming a peptide bond between the C-terminal GLYCINE of UBIQUITIN and the alpha-amino groups of LYSINE residues in the protein. The complexes play an important role in mediating the selective-degradation of short-lived and abnormal proteins. The complex of enzymes can be broken down into three components that involve activation of ubiquitin (UBIQUITIN-ACTIVATING ENZYMES), conjugation of ubiquitin to the ligase complex (UBIQUITIN-CONJUGATING ENZYMES), and ligation of ubiquitin to the substrate protein (UBIQUITIN-PROTEIN LIGASES).
RNA, Transfer, Trp
Mutation
Cullin Proteins
Alanine Dehydrogenase
An NAD-dependent enzyme that catalyzes the reversible DEAMINATION of L-ALANINE to PYRUVATE and AMMONIA. The enzyme is needed for growth when ALANINE is the sole CARBON or NITROGEN source. It may also play a role in CELL WALL synthesis because L-ALANINE is an important constituent of the PEPTIDOGLYCAN layer.
RNA, Transfer, Arg
Ligases
RNA, Transfer, Met
RNA, Transfer, Gly
Ubiquitin
A highly conserved 76-amino acid peptide universally found in eukaryotic cells that functions as a marker for intracellular PROTEIN TRANSPORT and degradation. Ubiquitin becomes activated through a series of complicated steps and forms an isopeptide bond to lysine residues of specific proteins within the cell. These "ubiquitinated" proteins can be recognized and degraded by proteosomes or be transported to specific compartments within the cell.
RNA, Transfer, Ile
Glutamate-Cysteine Ligase
RNA, Transfer, Glu
RNA, Transfer, Asp
RNA, Transfer, Val
RNA, Transfer, Gln
RNA, Transfer, Pro
Protein Binding
Binding Sites
tRNA synthetase mutants of Escherichia coli K-12 are resistant to the gyrase inhibitor novobiocin. (1/81)
In previous studies we demonstrated that mutations in the genes cysB, cysE, and cls (nov) affect resistance of Escherichia coli to novobiocin (J. Rakonjac, M. Milic, and D. J. Savic, Mol. Gen. Genet. 228:307-311, 1991; R. Ivanisevic, M. Milic, D. Ajdic, J. Rakonjac, and D. J. Savic, J. Bacteriol. 177:1766-1771, 1995). In this work we expand this list with mutations in rpoN (the gene for RNA polymerase subunit sigma54) and the tRNA synthetase genes alaS, argS, ileS, and leuS. Similarly to resistance to the penicillin antibiotic mecillinam, resistance to novobiocin of tRNA synthetase mutants appears to depend upon the RelA-mediated stringent response. However, at this point the overlapping pathways of mecillinam and novobiocin resistance diverge. Under conditions of stringent response induction, either by the presence of tRNA synthetase mutations or by constitutive production of RelA protein, inactivation of the cls gene diminishes resistance to novobiocin but not to mecillinam. (+info)SmpB, a unique RNA-binding protein essential for the peptide-tagging activity of SsrA (tmRNA). (2/81)
In bacteria, SsrA RNA recognizes ribosomes stalled on defective messages and acts as a tRNA and mRNA to mediate the addition of a short peptide tag to the C-terminus of the partially synthesized nascent polypeptide chain. The SsrA-tagged protein is then degraded by C-terminal-specific proteases. SmpB, a unique RNA-binding protein that is conserved throughout the bacterial kingdom, is shown here to be an essential component of the SsrA quality-control system. Deletion of the smpB gene in Escherichia coli results in the same phenotypes observed in ssrA-defective cells, including a variety of phage development defects and the failure to tag proteins translated from defective mRNAs. Purified SmpB binds specifically and with high affinity to SsrA RNA and is required for stable association of SsrA with ribosomes in vivo. Formation of an SmpB-SsrA complex appears to be critical in mediating SsrA activity after aminoacylation with alanine but prior to the transpeptidation reaction that couples this alanine to the nascent chain. SsrA RNA is present at wild-type levels in the smpB mutant arguing against a model of SsrA action that involves direct competition for transcription factors. (+info)Single-nucleotide polymorphisms can cause different structural folds of mRNA. (3/81)
Single-nucleotide polymorphisms (SNPs) are the most common type of genetic variation in man. Genes containing one or more SNPs can give rise to two or more allelic forms of mRNAs. These mRNA variants may possess different biological functions as a result of differences in primary or higher order structures that interact with other cellular components. Here we report the observation of marked differences in mRNA secondary structure associated with SNPs in the coding regions of two human mRNAs: alanyl tRNA synthetase and replication protein A, 70-kDa subunit (RPA70). Enzymatic probing of SNP-containing allelic fragments of the mRNAs revealed pronounced allelic differences in cleavage pattern at sites 14 or 18 nt away from the SNP, suggesting that a single-nucleotide variation can give rise to different mRNA folds. By using phosphorothioate oligodeoxyribonucleotides complementary to the region of different allelic structures in the RPA70 mRNA, but not extending to the SNP itself, we find that the SNP exerts an allele-specific effect on the accessibility of its flanking site in the endogenous human RPA70 mRNA. This further supports the allele-specific structural features identified by enzymatic probing. These results demonstrate the contribution of common genetic variation to structural diversity of mRNA and suggest a broader role than previously thought for the effects of SNPs on mRNA structure and, ultimately, biological function. (+info)CDC64 encodes cytoplasmic alanyl-tRNA synthetase, Ala1p, of Saccharomyces cerevisiae. (4/81)
The cdc64-1 mutation causes G(1) arrest in Saccharomyces cerevisiae corresponding to a type II Start phenotype. We report that CDC64 encodes Ala1p, an alanyl-tRNA synthetase. Thus, cdc64-1 might affect charging of tRNA(Ala) and thereby initiation of cell division. (+info)Identification of discriminator base atomic groups that modulate the alanine aminoacylation reaction. (5/81)
Specific aminoacylation of tRNAs involves activation of an amino acid with ATP followed by amino acid transfer to the tRNA. Previous work showed that the transfer of alanine from Escherichia coli alanyl-tRNA synthetase to a cognate RNA minihelix involves a transition state sensitive to changes in the tRNA acceptor stem. Specifically, the "discriminator" base at position 73 of minihelix(Ala) is a critical determinant of the transfer step of aminoacylation. This single-stranded nucleotide has previously been shown by solution NMR to be stacked predominantly onto G(1) of the first base pair of the alanine acceptor stem helix. In this work, RNA duplex(Ala) variants were prepared to investigate the role of specific discriminator base atomic groups in aminoacylation catalytic efficiency. Results indicate that the purine structure appears to be important for stabilization of the transition state and that major groove elements are more critical than those located in the minor groove. This result is in accordance with the predicted orientation of a class II synthetase at the end of the acceptor helix. In particular, substitution of the exocyclic amino group of A(73) with a keto-oxygen resulted in negative discrimination at this site. Taken together, these new results are consistent with the involvement of major groove atomic groups of the discriminator base in the formation of the transition state for the amino acid transfer step. (+info)Expression of Arabidopsis thaliana mitochondrial alanyl-tRNA synthetase is not sufficient to trigger mitochondrial import of tRNAAla in yeast. (6/81)
It has often been suggested that precursors to mitochondrial aminoacyl-tRNA synthetases are likely carriers for mitochondrial import of tRNAs in those organisms where this process occurs. In plants, it has been shown that mutation of U(70) to C(70) in Arabidopsis thaliana tRNA(Ala)(UGC) blocks aminoacylation and also prevents import of the tRNA into mitochondria. This suggests that interaction of tRNA(Ala) with alanyl-tRNA synthetase (AlaRS) is necessary for import to occur. To test whether this interaction is sufficient to drive import, we co-expressed A. thaliana tRNA(Ala)(UGC) and the precursor to the A. thaliana mitochondrial AlaRS in Saccharomyces cerevisiae. The A. thaliana enzyme and its cognate tRNA were correctly expressed in yeast in vivo. However, although the plant AlaRS was efficiently imported into mitochondria in the transformed strains, we found no evidence for import of the A. thaliana tRNA(Ala) nor of the endogenous cytosolic tRNA(Ala) isoacceptors. We conclude that at least one other factor besides the mitochondrial AlaRS precursor must be involved in mitochondrial import of tRNA(Ala) in plants. (+info)Importance of discriminator base stacking interactions: molecular dynamics analysis of A73 microhelix(Ala) variants. (7/81)
Transfer of alanine from Escherichia coli alanyl-tRNA synthetase (AlaRS) to RNA minihelices that mimic the amino acid acceptor stem of tRNA(Ala) has been shown, by analysis of variant minihelix aminoacylation activities, to involve a transition state sensitive to changes in the 'discriminator' base at position 73. Solution NMR has indicated that this single-stranded nucleotide is predominantly stacked onto G1 of the first base pair of the alanine acceptor stem helix. We report the activity of a new variant with the adenine at position 73 substituted by its non-polar isostere 4-methylindole (M). Despite lacking N7, this analog is well tolerated by AlaRS. Molecular dynamics (MD) simulations show that the M substitution improves position 73 base stacking over G1, as measured by a stacking lifetime analysis. Additional MD simulations of wild-type microhelix(Ala) and six variants reveal a positive correlation between N73 base stacking propensity over G1 and aminoacylation activity. For the two DeltaN7 variants simulated we found that the propensity to stack over G1 was similar to the analogous variants that contain N7 and we conclude that the decrease in aminoacylation efficiency observed upon deletion of N7 is likely due to loss of a direct stabilizing interaction with the synthetase. (+info)Origin of mitochondria in relation to evolutionary history of eukaryotic alanyl-tRNA synthetase. (8/81)
The origin of the eukaryotic cell remains an unsolved question. Numerous experimental and phylogenetic observations support the symbiotic origin of the modern eukaryotic cell, with its nucleus and (typically) mitochondria. Incorporation of mitochondria has been proposed to precede development of the nucleus, but it is still unclear whether mitochondria were initially part of basal eukaryotes. Data on alanyl-tRNA synthetase from an early eukaryote and other sources are presented and analyzed here. These data are consistent with the notion that mitochondrial genesis did not significantly precede nucleus formation. Moreover, the data raise the possibility that diplomonads are primary amitochondriates that radiated from the eukaryotic lineage before mitochondria became fully integrated as a cellular organelle. (+info)
A mammalian cell mutant with an altered alanyl-trna synthetase. Abstr by K Sato
AARS Polyclonal Antibody | EpiGentek
AARS1 Gene - GeneCards | SYAC Protein | SYAC Antibody
PathBank
Mitochondrial aminoacyl-tRNA synthetase disorders: an emerging group of developmental disorders of myelination | Journal of...
British Library EThOS: Glycyl-tRNA synthetase mutations in neurological disease :
mechanisms and models
dtd - D-aminoacyl-tRNA deacylase - Escherichia coli (strain K12) - dtd gene & protein
Human AARS1 P49588 Information | Boster Bio
alaS - Alanine--tRNA ligase - Aquifex aeolicus (strain VF5) - alaS gene & protein
ENZYME entry 2.3.2.10
PL-900 Power Platform Fundamentals Practice Tests ...
Addgene: PL-452 N-CyPet
Accounting for horizontal gene transfers explains conflicting hypotheses regarding the position of aquificales in the phylogeny...
FRI0468 Long-Term Outcome of Pulmonary Function in the Anti-Synthetase Syndrome | Annals of the Rheumatic Diseases
Q18BE7 | alaS | Alanine--tRNA ligase | Druggability | Cancer
The distal hereditary motor neuropathies | Journal of Neurology, Neurosurgery & Psychiatry
KEGG BRITE: KEGG Orthology (KO) - Brevibacillus brevis
AARS Hot Topics - July 15, 2017 Issue | American Acne and Rosacea Society
Anti-valyl tRNA synthetase antibody [VARSA7E6] (ab50898)
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KEGG BRITE: KEGG Orthology (KO) - Halomonas chromatireducens
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Anti-Glutamyl Prolyl tRNA synthetase antibody - N-terminal (ab71253)
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Seryl tRNA synthetase Antibody (1H4) [DyLight 488] (H00006301-M01G): Novus Biologicals
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Aars | definition of Aars by Medical dictionary
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Search Results
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Histidyl TRNA Synthetase (HARS) ELISA Kits
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Alanine-tRNA ligase
... alanine-transfer RNA ligase, alanine transfer RNA synthetase, alanine tRNA synthetase, alanine translase, alanyl-transfer ... In enzymology, an alanine-tRNA ligase (EC 6.1.1.7) is an enzyme that catalyzes the chemical reaction ATP + L-alanine + tRNAAla ... L-alanine, and tRNA(Ala), whereas its 3 products are AMP, diphosphate, and L-alanyl-tRNA(Ala). This enzyme belongs to the ... The systematic name of this enzyme class is L-alanine:tRNAAla ligase (AMP-forming). Other names in common use include alanyl- ...
AARS2
Alanyl-tRNA synthetase, mitochondrial, also known as alanine-tRNA ligase (AlaRS) or alanyl-tRNA synthetase 2 (AARS2), is an ... "Entrez Gene: alanyl-tRNA synthetase 2". Bonnefond L, Fender A, Rudinger-Thirion J, Giegé R, Florentz C, Sissler M (March 2005 ... "Toward the full set of human mitochondrial aminoacyl-tRNA synthetases: characterization of AspRS and TyrRS". Biochemistry. 44 ( ... "Toward the full set of human mitochondrial aminoacyl-tRNA synthetases: characterization of AspRS and TyrRS". Biochemistry. 44 ( ...
Aspartate-tRNA(Asn) ligase
This enzyme participates in alanine and asparagine metabolism. Ibba M, Soll D (2000). "Aminoacyl-tRNA synthesis". Annual Review ... Aspartate-tRNAAsn ligase (EC 6.1.1.23, nondiscriminating aspartyl-tRNA synthetase) is an enzyme with systematic name L- ... When this enzyme acts on tRNAAsp, it catalyses the same reaction as EC 6.1.1.12, aspartate---tRNA ligase. It has, however, ... This enzyme belongs to the family of ligases, to be specific those forming carbon-oxygen bonds in aminoacyl-tRNA and related ...
Aspartate-tRNA ligase
This enzyme participates in alanine and aspartate metabolism and aminoacyl-trna biosynthesis. As of late 2007, 10 structures ... In enzymology, an aspartate-tRNA ligase (EC 6.1.1.12) is an enzyme that catalyzes the chemical reaction ATP + L-aspartate + ... and L-aspartyl-tRNA(Asp). This enzyme belongs to the family of ligases, to be specific those forming carbon-oxygen bonds in ... aminoacyl-tRNA and related compounds. The systematic name of this enzyme class is L-aspartate:tRNAAsp ligase (AMP-forming). ...
Asparagine-tRNA ligase
This enzyme participates in alanine and aspartate metabolism and aminoacyl-trna biosynthesis. As of late 2007, 3 structures ... In enzymology, an asparagine-tRNA ligase (EC 6.1.1.22) is an enzyme that catalyzes the chemical reaction ATP + L-asparagine + ... and L-asparaginyl-tRNA(Asn). This enzyme belongs to the family of ligases, to be specific those forming carbon-oxygen bonds in ... aminoacyl-tRNA and related compounds. The systematic name of this enzyme class is L-asparagine:tRNAAsn ligase (AMP-forming). ...
Morganellaceae
... histidine-tRNA ligase, and N-acetylmuramoyl-L-alanine amidase. These molecular signatures provide a novel and reliable means of ...
D-alanine-poly(phosphoribitol) ligase
This enzyme belongs to the family of ligases, to be specific those forming carbon-oxygen bonds in aminoacyl-tRNA and related ... D-alanine: membrane acceptor ligase, D-alanine-D-alanyl carrier protein ligase, D-alanine-membrane acceptor ligase, and D- ... In enzymology, a D-alanine-poly(phosphoribitol) ligase (EC 6.1.1.13) is an enzyme that catalyzes the chemical reaction ATP + D- ... The systematic name of this enzyme class is D-alanine:poly(phosphoribitol) ligase (AMP-forming). Other names in common use ...
Caldibacillus
O-succinylbenzoate-CoA ligase, tetratricopeptide repeat protein, d-alanyl-d-alanine carboxypeptidase, ribonuclease Z, late ... tRNA uridine-5- carboxymethylaminomethyl(34) synthesis enzyme MnmG, ...
List of EC numbers (EC 6)
... leucine-tRNA ligase EC 6.1.1.5: isoleucine-tRNA ligase EC 6.1.1.6: lysine-tRNA ligase EC 6.1.1.7: alanine-tRNA ligase EC 6.1. ... valine-tRNA ligase EC 6.1.1.10: methionine-tRNA ligase EC 6.1.1.11: serine-tRNA ligase EC 6.1.1.12: aspartate-tRNA ligase EC ... glycine-tRNA ligase EC 6.1.1.15: proline-tRNA ligase EC 6.1.1.16: cysteine-tRNA ligase EC 6.1.1.17: glutamate-tRNA ligase EC ... glutamine-tRNA ligase EC 6.1.1.19: arginine-tRNA ligase EC 6.1.1.20: phenylalanine-tRNA ligase EC 6.1.1.21: histidine-tRNA ...
List of MeSH codes (D08)
... alanine-tRNA ligase MeSH D08.811.464.263.200.100 - arginine-tRNA ligase MeSH D08.811.464.263.200.150 - aspartate-tRNA ligase ... glutamate-trna ligase MeSH D08.811.464.263.200.350 - glycine-trna ligase MeSH D08.811.464.263.200.400 - histidine-trna ligase ... isoleucine-trna ligase MeSH D08.811.464.263.200.500 - leucine-trna ligase MeSH D08.811.464.263.200.550 - lysine-trna ligase ... serine-trna ligase MeSH D08.811.464.263.200.800 - threonine-tRNA ligase MeSH D08.811.464.263.200.850 - tryptophan-tRNA ligase ...
Transfer-messenger RNA
... including the acceptor stem with elements like those in alanine tRNA that promote its aminoacylation by alanine-tRNA ligase. It ... The standard bacterial tmRNA consists of a tRNA(Ala)-like domain (allowing addition of a non-encoded alanine to mRNAs that ... the tmRNA can be charged by alanyl-tRNA synthetase with alanine. CLPP Ribosome Messenger RNA Keiler KC (2008). "Biology of ... With the exception of the N-terminal alanine, which comes from the 3' end of tmRNA itself, this tag sequence was traced to a ...
Asparaginyl-tRNA synthase (glutamine-hydrolysing)
This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds carbon-nitrogen ligases with ... This enzyme participates in glutamate metabolism and alanine and aspartate metabolism. Min B, Pelaschier JT, Graham DE, Tumbula ... aspartyl-tRNA(Asn), and L-glutamine, whereas its 4 products are ADP, phosphate, asparaginyl-tRNA(Asn), and L-glutamate. ... In enzymology, an asparaginyl-tRNA synthase (glutamine-hydrolysing) (EC 6.3.5.6) is an enzyme that catalyzes the chemical ...
Glutaminyl-tRNA synthase (glutamine-hydrolysing)
This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds carbon-nitrogen ligases with ... This enzyme participates in glutamate metabolism and alanine and aspartate metabolism. Horiuchi KY, Harpel MR, Shen L, Luo Y, ... glutamyl-tRNA(Gln), and L-glutamine, whereas its 4 products are ADP, phosphate, glutaminyl-tRNA(Gln), and L-glutamate. ... Ibba M, Soll D (2000). "Aminoacyl-tRNA synthesis". Annu. Rev. Biochem. 69: 617-50. doi:10.1146/annurev.biochem.69.1.617. PMID ...
Selenocysteine
The selenocysteine tRNAs are initially charged with serine by seryl-tRNA ligase, but the resulting Ser-tRNASec is not used for ... Selenocysteine is decomposed by the enzyme selenocysteine lyase into L-alanine and selenide. As of 2021[update], 136 human ... two enzymes are required to convert tRNA-bound seryl residue into tRNA selenocysteinyl residue: PSTK (O-phosphoseryl-tRNA[Ser] ... The primary and secondary structure of selenocysteine-specific tRNA, tRNASec, differ from those of standard tRNAs in several ...
List of biomolecules
... in this case alanine). Lactase Lactic acid Lactose Lanolin Lauric acid Lectin Leptin Leptomycin B Leucine Leukotriene Ligase ... tRNA) Triacsin C Thyroid-stimulating hormone (TSH) Thyrotropin-releasing hormone (TRH) Thyroxine (T4) Tocopherol (Vitamin E) ... prefix such as L-alanine or DL-alanine, please see the parent page ( ... Aequorin Aflatoxin Agar Alamethicin Alanine Albumins Aldosterone Aleurone Alpha-amanitin Alpha-MSH (Melaninocyte stimulating ...
List of EC numbers (EC 4)
3-chloro-D-alanine dehydrochlorinase EC 4.5.1.3: dichloromethane dehalogenase EC 4.5.1.4: L-2-amino-4-chloropent-4-enoate ... tRNA-intron lyase EC 4.6.1.17: cyclic pyranopterin monophosphate synthase * EC 4.6.1.18: pancreatic ribonuclease * EC 4.6.1.19 ... heme ligase EC 4.99.1.9:: coproporphyrin ferrochelatase * EC 4.99.1.10: magnesium dechelatase * EC 4.99.1.11: sirohydrochlorin ... tRNA 4-demethylwyosine synthase (AdoMet-dependent) * EC 4.1.3.45: 3-hydroxybenzoate synthase * EC 4.1.3.46: (R)-citramalyl-CoA ...
N-end rule
The removal of the methionine is more efficient when the second residue is small and uncharged (for example alanine), but ... In eukaryotic cells, these N-terminal residues are recognized and targeted by ubiquitin ligases, mediating ubiquitination ... destabilising residues are modified by the attachment of a Primary destabilising residue by the enzyme leucyl/phenylalanyl-tRNA ... This study revealed that Alanine, Serine, Threonine, and Valine were the most abundant N-terminal residues, while Leucine, ...
TRNA-intron endonuclease
Popow J, Schleiffer A, Martinez J (August 2012). "Diversity and roles of (t)RNA ligases". Cellular and Molecular Life Sciences ... leading to a substitution at position 307 of alanine by serine. This mutation causes destabilization of the β-β-interaction, ... The use of tRNA-intron endonuclease in pre-tRNA intron excision is just one of the steps for tRNA maturation. pre-tRNAs undergo ... tRNA-intron lyase (EC 4.6.1.16, tRNA intron endonuclease, transfer ribonucleate intron endoribonuclease, tRNA splicing ...
List of EC numbers (EC 3)
... alanine carboxypeptidase EC 3.4.17.7: Now EC 3.5.1.28, N-acetylmuramoyl-L-alanine amidase EC 3.4.17.8: muramoylpentapeptide ... tRNA(adenine34) deaminase * EC 3.5.4.34: tRNAAla(adenine37) deaminase * EC 3.5.4.35: tRNA(cytosine8) deaminase * EC 3.5.4.36: ... glutamateammonia ligase] phosphorylase EC 3.1.4.16: 2′,3′-cyclic-nucleotide 2′-phosphodiesterase EC 3.1.4.17: 3′,5′-cyclic- ... alanine carboxypeptidase EC 3.4.17.7: Now EC 3.5.1.28, N-acetylmuramoyl-L-alanine amidase EC 3.4.17.8: muramoylpentapeptide ...
Mitochondrion
Mitochondrial tRNA genes have different sequences from the nuclear tRNAs, but lookalikes of mitochondrial tRNAs have been found ... which converts lactate and de-aminated alanine into glucose, under the influence of high levels of glucagon and/or epinephrine ... kynurenine hydroxylase and fatty acid Co-A ligase. Disruption of the outer membrane permits proteins in the intermembrane space ... It encodes 37 genes: 13 for subunits of respiratory complexes I, III, IV and V, 22 for mitochondrial tRNA (for the 20 standard ...
List of enzymes
L-firefly luciferin-CoA ligase EC 6.2.1.53: L-proline-L-prolyl-carrier protein ligase EC 6.2.1.54: D-alanine-D-alanyl-carrier ... L-seryl-tRNA(Sec) selenium transferase EC 2.9.1.2: O-phospho-L-seryl-tRNA(Sec):L-selenocysteinyl-tRNA synthase Hydrolytic ... Glutarate-CoA ligase EC 6.2.1.7: Cholate-CoA ligase EC 6.2.1.8: Oxalate-CoA ligase EC 6.2.1.9: Malate-CoA ligase EC 6.2.1.10: ... ligase EC 6.2.1.23: Dicarboxylate-CoA ligase EC 6.2.1.24: Phytanate-CoA ligase EC 6.2.1.25: Benzoate-CoA ligase EC 6.2.1.26: o- ...
Chromosome 2
Ubiquitin ligase PLGLB2: Plasminogen-related protein B POLR1A: DNA-directed RNA polymerase I subunit RPA1 PREPL: Prolyl ... "genetype trna"[Properties] OR "genetype scrna"[Properties] OR "genetype snrna"[Properties] OR "genetype snorna"[Properties]) ... alanine-glyoxylate aminotransferase (oxalosis I; hyperoxaluria I; glycolicaciduria; serine-pyruvate aminotransferase) ALS2: ... encoding protein Neuralized E3 ubiquitin protein ligase 3 NCL: Nucleolin NR4A2: nuclear receptor subfamily 4, group A, member 2 ...
Artificial gene synthesis
Taq DNA ligase repairs the nicks on both DNA strands. Because the T5 exonuclease is heat labile, it is inactivated at 50 °C ... Synthesis of the first complete gene, a yeast tRNA, was demonstrated by Har Gobind Khorana and coworkers in 1972. Synthesis of ... Total synthesis of the structural gene for an alanine transfer ribonucleic acid from yeast". Journal of Molecular Biology. 72 ( ... Next, each linker part is attached to its respective DNA part by incubating with T4 DNA ligase. Each DNA part will have a ...
List of EC numbers (EC 2)
... glutamate-tRNA ligase, EC 1.2.1.70, glutamyl-tRNA reductase and EC 5.4.3.8 EC 2.7.2.14: branched-chain-fatty-acid kinase EC 2.7 ... D-alanine 2-hydroxymethyltransferase EC 2.1.2.8: deoxycytidylate 5-hydroxymethyltransferase EC 2.1.2.9: methionyl-tRNA ... tRNA (guanine46-N7)-methyltransferase EC 2.1.1.34: tRNA (guanosine18-2′-O)-methyltransferase EC 2.1.1.35: tRNA (uracil54-C5)- ... tRNA (guanine110-N2)-dimethyltransferase EC 2.1.1.214: tRNA (guanine10-N2)-methyltransferase EC 2.1.1.215: tRNA (guanine26-N2/ ...
HOMD :: SEQF2940
Alanine--tRNA ligase. 183. SEQF2940,KI515728.1. SEQF2940_00186 jb [NA] [AA] 1386/461. 187677-186292. putative AAA domain- ... Aspartate--tRNA(Asp/Asn) ligase. 186. SEQF2940,KI515728.1. SEQF2940_00189 jb [NA] [AA] 933/310. 191067-191999. hypothetical ... Histidine--tRNA ligase. 191. SEQF2940,KI515728.1. SEQF2940_00194 jb [NA] [AA] 636/211. 197458-196823. Hydroxyacylglutathione ... Pup--protein ligase. 70. SEQF2940,KI515728.1. SEQF2940_00072 jb [NA] [AA] 192/63. 69135-68944. Prokaryotic ubiquitin-like ...
HOMD :: SEQF2448
Alanine--tRNA ligase. 7. SEQF2448,KI273076.1. SEQF2448_00007 jb [NA] [AA] 1155/384. 4062-2908. Glycerate 2-kinase. ... tRNA ligase alpha subunit. 96. SEQF2448,KI273077.1. SEQF2448_00098 jb [NA] [AA] 2427/808. 85828-88254. Phenylalanine--tRNA ... D-alanyl-D-alanine carboxypeptidase DacB. 20. SEQF2448,KI273076.1. SEQF2448_00020 jb [NA] [AA] 1416/471. 19857-21272. ... Putative TrmH family tRNA/rRNA methyltransferase. 118. SEQF2448,KI273077.1. SEQF2448_00121 jb [NA] [AA] 1014/337. 112542-113555 ...
Code System Concept
Alanyl-tRNA synthetase Active Synonym false false 2971540018 Alanine-transfer ribonucleic acid ligase Active Synonym false ... Alanine-transfer ribonucleic acid ligase (substance). Code System Preferred Concept Name. Alanine-transfer ribonucleic acid ... Alanine-tRNA ligase Active Synonym false false 113649019 ...
DeCS
Alanine-tRNA ligase - Concept préféré Concept UI. M0000623. Terme préféré. Alanine-tRNA ligase ... Alanine-tRNA ligase Descripteur en anglais: Alanine-tRNA Ligase Descripteur en espagnol: Alanina-ARNt Ligasa Espagnol dEspagne ... An enzyme that activates alanine with its specific transfer RNA. EC 6.1.1.7.. ... Alanina-tRNA Ligase Synonymes:. Alanine-ARNt ligase. Alanine-ARNt synthétase. Alanyl-ARNt synthétase. ...
UBCG] Gene set - EzBioCloud Help center
Alanine-tRNA ligase. argS. J. COG0018. TIGR00456. Arginine-tRNA ligase. aspS. J. COG0173. TIGR00459. Aspartate-tRNA ligase. ... Histidine-tRNA ligase. ileS. J. COG0060. TIGR00392. Isoleucine-tRNA ligase 1. infB. J. COG0532. TIGR00487. Translation ... Phenylalanine-tRNA ligase alpha subunit. pheT. J. COG0073. TIGR00472. Phenylalanine-tRNA ligase beta subunit. ...
HOMD :: SEQF1909
Alanine--tRNA ligase. 199. SEQF1909,AJZR01000006.1. SEQF1909_00205 jb [NA] [AA] 564/187. 96983-97546. Acyl carrier protein ... Phenylalanine--tRNA ligase alpha subunit. 39. SEQF1909,AJZR01000002.1. SEQF1909_00039 jb [NA] [AA] 2442/813. 37456-39897. ... Alanine racemase 1. 123. SEQF1909,AJZR01000006.1. SEQF1909_00128 jb [NA] [AA] 768/255. 15711-14944. 2%2C3-dehydroadipyl-CoA ... D-alanyl-D-alanine carboxypeptidase. 138. SEQF1909,AJZR01000006.1. SEQF1909_00144 jb [NA] [AA] 876/291. 31939-31064. Succinate ...
Network Portal - Function aminoacyl-tRNA ligase activity
alanine-tRNA ligase activity. GO:0004814. arginine-tRNA ligase activity. GO:0004815. aspartate-tRNA ligase activity. ... aminoacyl-tRNA ligase activity. id: GO:0004812. name: aminoacyl-tRNA ligase activity. namespace: molecular_function. type: go. ... Description: Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and ... valine-tRNA ligase activity. GO:0043767. pyrrolysyl-tRNA synthetase activity. GO:0043816. phosphoserine-tRNA(Cys) ligase ...
SustainPineDB
Protein Ontology
lcl|LHPG02000004.1 cds PRW59070.1 7315 details
CCL20590 details
Systematic identification of miRNA-regulatory networks unveils their potential roles in sugarcane response to Sorghum mosaic...
ANKRD16 prevents neuron loss caused by an editing-defective tRNA synthetase<...
Alanine-tRNA Ligase Medicine & Life Sciences 100% * Amino Acyl-tRNA Synthetases Medicine & Life Sciences 99% ... Editing domains of aminoacyl tRNA synthetases correct tRNA charging errors to maintain translational fidelity. A mutation in ... N2 - Editing domains of aminoacyl tRNA synthetases correct tRNA charging errors to maintain translational fidelity. A mutation ... AB - Editing domains of aminoacyl tRNA synthetases correct tRNA charging errors to maintain translational fidelity. A mutation ...
PathBank
ISMARA results: CEBPB
threonine-tRNA ligase activity(GO:0004829). 0.0. 0.1. GO:0004813. alanine-tRNA ligase activity(GO:0004813). ... glutamate-tRNA ligase activity(GO:0004818) proline-tRNA ligase activity(GO:0004827). ... glutamine-tRNA ligase activity(GO:0004819) leucine-tRNA ligase activity(GO:0004823). ... isoleucine-tRNA ligase activity(GO:0004822). 0.0. 0.0. GO:1990259. protein-glutamine N-methyltransferase activity(GO:0036009) ...
En donde puedo comprar esteroides en guatemala steroider online køb, sm bodybuilding 2022 resultat | Clean Coats Painting
MMTB
6.1.1.15 proline---tRNA ligase 6.1.1.20 phenylalanine---tRNA ligase 6.1.1.6 lysine---tRNA ligase 6.1.1.7 alanine---tRNA ligase ... tRNAMet + L-alanine + ATP <=> L-alanyl-[tRNAAla] + diphosphate + AMP 6.1.1.7 alanine---tRNA ligase - M ... ATP + L-alanine + anticapsin <=> ADP + phosphate + L-alanyl-L-anticapsin + H+ 6.3.2.49 L-alanine---L-anticapsin ligase - BMK ... L-glutamate + L-alanine + ATP <=> gamma-L-glutamyl-D-alanine + ADP + phosphate + H+ 6.3.2.2 glutamate---cysteine ligase - ...
Model Search | BioModels
Alanine--tRNA ligase, mitochondrial (4) * 1,3-beta-glucan synthase component FKS1 (4) ... Glutamate--tRNA ligase, mitochondrial (4) * High-affinity glucose transporter HXT2 (4) * Tyrosine--tRNA ligase, mitochondrial ( ... Phenylalanine--tRNA ligase beta subunit (4) * Phenylalanine--tRNA ligase alpha subunit (4) ...
AARS Gene - genomics-online.com | cDNA | ORF | Primers | Kits
alanine--tRNA ligase. *transfer RNA-Ala synthetase. Proteomics products related to AARS Gene. Other products related to AARS ... AARS (Alanyl tRNA Synthetase, AARS). Short Description: The human alanyl-tRNA synthetase (AARS) belongs to a family of tRNA ... tRNA synthases are the enzymes that interpret the RNA code and attach specific aminoacids to the tRNAs that contain the cognate ... Class II tRNA synthases evolved early in evolution and are highly conserved. This is reflected by the fact that 498 of the 968- ...
Búsqueda | BVS Bolivia
Domain IPR003439:ABC transporter-like
Alanine-tRNA ligase, class IIc 32 Domain IPR015879:Aromatic-ring-hydroxylating dioxygenase, alpha subunit, C-terminal domain 32 ... D-alanine--D-alanine ligase/VANA/B/C, conserved site 37 Family IPR006127:Periplasmic solute binding protein, ZnuA-like 37 ... D-alanine--D-alanine ligase, N-terminal domain 34 Domain IPR001086:Prephenate dehydratase 34 Domain IPR004150:NAD-dependent DNA ... D-alanine--D-alanine ligase 28 Domain IPR012792:3-oxoacid CoA-transferase, subunit A 28 Family IPR003170:UDP-N- ...
ALA1 - LEU4 | S. cerevisiae SSL interaction - Slorth
aminoacyl-tRNA ligase activity. alanine-tRNA ligase activity. ATP binding. nucleotide binding. nucleic acid binding. ligase ... tRNA binding. amino acid binding. metal ion binding. ligase activity. RNA binding. AARS2 (H. sapiens). AARS (H. sapiens). ... activity, forming aminoacyl-tRNA and related compounds. ...
Genes | Free Full-Text | Impacts of the Type I Toxin-Antitoxin System, SprG1/SprF1, on Staphylococcus aureus Gene Expression
Alanine dehydrogenase 2 (Ald2). Q99TF4. 1.86 ↓. 7. Phenylalanine--tRNA ligase α subunit (PheS). P68848. 1.55 ↓. ... Glutamate----tRNA ligase (GltX). P99170. 1.74 ↓. 1.72 ↓. 2. 1-pyrroline-5-carboxylate dehydrogenase (RocA). P99076. 1.96 ↓. ... Succinate--CoA ligase (ADP-forming) subunit α (SucD). P99070. 1.55 ↓. 3. Putative peptidyl-prolyl cis-trans isomerase (PpiB). ... Formate--tetrahydrofolate ligase (FHS). Q7A535. 3.41 ↓. 2.75 ↓. 18. Phosphoenolpyruvate-protein phosphotransferase (PtsI). ...
SCOP 1.57: Superfamily c.26.1: Nucleotidylyl transferase
SMART: Pfam domain Anticodon 1
The aminoacyl-tRNA synthetases (also known as aminoacyl-tRNA ligases) catalyse the attachment of an amino acid to its cognate ... The synthetases specific for alanine, asparagine, aspartic acid, glycine, histidine, phenylalanine, proline, serine, threonine ... In reactions catalysed by the class I aminoacyl-tRNA synthetases, the aminoacyl group is coupled to the 2-hydroxyl of the tRNA ... Based on their mode of binding to the tRNA acceptor stem, both classes of tRNA synthetases have been subdivided into three ...
SMPDB
tRNA(Met). Selenomethionyl-. tRNA(Met). Aspartate. Metabolism. Glutamate. Metabolism. Alanine. Metabolism. D-Arginine and. D- ... tRNA ligase,. cytoplasmic. Bifunctional. 3-. phosphoadenosine. 5-. phosphosulfate. synthase 1. Bifunctional. 3-. ... Alanine. Metabolism. D-Arginine and. D-Ornithine. Metabolism. Internal. digestion and. absorption. ... L-Alanine. Selenite. Selenite. Se-Methylselenocysteine. Se-Methylselenocysteine. Selenocysteine. Selenocysteine. Hydrogen ...
A systems biology approach to investigate the response of Synechocystis sp. PCC6803 to a high salt environment | Aquatic...
Cell envelope enzyme UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diamino-pimelate-D-alanyl-D-alanine ligase (p+ = NA, 0.9918) is ... the 1.83 and 2.32-fold induction of glutamyl-tRNA synthetase (p+ = 1, 0.99394) has been observed previously in the long-term [ ... Smith CA: Structure, function and dynamics in the mur family of bacterial cell wall ligases. J Mol Biol. 2006, 362: 640-655. ... ammonia ligase (p+ = NA, 0.9965), which functions in the same pathway. Both proteins have not previously been identified in the ...
Ligase - Wikipédia
... alanine ligase EC 6.3.2.2 glutamate-cysteine ligase EC 6.3.2.3 glutathione synthase EC 6.3.2.4 D-alanine-D-alanine ligase EC ... EC 6.3.4.17 formate-dihydrofolate ligase EC 6.3.4.18 5-(carboxyamino)imidazole ribonucleotide synthase EC 6.3.4.19 tRNAIle- ... γ-L-glutamate ligase EC 6.3.2.35 D-alanine-D-serine ligase EC 6.3.2.36 4-phosphopantoate-β-alanine ligase EC 6.3.2.37 UDP-N- ... ARNt ligase EC 6.1.1.6 lysine ARNt ligase EC 6.1.1.7 alanine ARNt ligase EC 6.1.1.8 supprimé EC 6.1.1.9 valine ARNt ligase EC ...
SynthetaseAminoacyl tRNA syntheThreonineEnzymesAmino acidCysteineMRNAGeneRRNAIsoleucineCatalyseBiosynthesisAcceptorSynthaseLeucylHydrolysisActivityEnzymeSerineGlutamineInvolvesReactionsClass IIProcessSynthetaseMitochondrialSubunitCysteine-tRNA lAminoacyl-tRNA syntheAaRSDiphthine-ammoniAminoacylationHistidineCognateUbiquitin ligaseSynthetasesGenesRibosomeAttachmentProteinsCatalyzes
Synthetase5
- A mutation in the editing domain of alanyl tRNA synthetase (AlaRS) in Aars sti mutant mice results in an increase in the production of serine-mischarged tRNA Ala and the degeneration of cerebellar Purkinje cells. (elsevier.com)
- These results identify an amino-acid-accepting co-regulator of tRNA synthetase editing as a new layer of the machinery that is essential to the prevention of severe pathologies that arise from defects in editing. (elsevier.com)
- A mutation in the editing domain of alanyl tRNA synthetase (AlaRS) in Aarssti mutant mice results in an increase in the production of serine-mischarged tRNAAla and the degeneration of cerebellar Purkinje cells. (elsevier.com)
- The human alanyl-tRNA synthetase (AARS) belongs to a family of tRNA synthases, of the class II enzymes. (genomics-online.com)
- These enzymes are involved in joining together 2 substrates e.g., alanyl-t-RNA synthetase, glutamine synthetase, DNA ligases. (amano-enzyme.com)
Aminoacyl tRNA synthe3
- Editing domains of aminoacyl tRNA synthetases correct tRNA charging errors to maintain translational fidelity. (elsevier.com)
- The 20 aminoacyl-tRNA synthetases are divided into two classes, I and II. (embl.de)
- In reactions catalysed by the class I aminoacyl-tRNA synthetases, the aminoacyl group is coupled to the 2'-hydroxyl of the tRNA, while, in class II reactions, the 3'-hydroxyl site is preferred. (embl.de)
Threonine1
- Compositional properties of Threonine--tRNA ligase (bottom) versus UniprotKB/SwissProt (top). (ucy.ac.cy)
Enzymes5
- tRNA synthases are the enzymes that interpret the RNA code and attach specific aminoacids to the tRNAs that contain the cognate trinucleotide anticodons. (genomics-online.com)
- Le nom courant des enzymes de type ligase inclut souvent le terme « ligase » comme l' ADN ligase du phage T4 utilisée pour structurer des fragments d' ADN . (wikipedia.org)
- Attention cependant à ne pas confondre les enzymes synthétases avec les enzymes synthases (qui sont toutes deux des enzymes du groupe des ligases). (wikipedia.org)
- Les ligases sont classées EC 6 dans la nomenclature EC des enzymes. (wikipedia.org)
- These enzymes catalyze the transfer of a particular group from one substrate to another e.g., aspartate amino transferase (AST), alanine aminotransferase (ALT), hexokinase, phosphoglucomutase, hexose- 1-phosphate uridyltransferase, ornithine carbamoyl transferase etc. (amano-enzyme.com)
Amino acid5
- Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP. (systemsbiology.net)
- They consist of a catalytic domain which interacts with the amino acid acceptor-T psi C helix of the tRNA, and a second domain which interacts with the rest of the tRNA structure. (genomics-online.com)
- This helps bind amino-acid to tRNA. (studyread.com)
- We then establish a genetic firewall by discovering viral tRNAs that provide exceptionally efficient codon reassignment allowing us to develop cells bearing an amino acid-swapped genetic code that reassigns two of the six serine codons to leucine during translation. (bvsalud.org)
- E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. (cusabio.com)
Cysteine2
- As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. (string-db.org)
- Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. (cusabio.com)
MRNA1
- Another undetectable mRNA existing addition was that transition receptor ligase NCAPD2 and NCAPH are complete upon contraction transcription, frequently by forest or formalism replication( Matsuoka et al. (evakoch.com)
Gene1
- Here we show that such mobile transfer RNAs (tRNAs) enable gene transfer and allow viral replication in Escherichia coli despite the genome-wide removal of 3 of the 64 codons and the previously essential cognate tRNA and release factor genes. (bvsalud.org)
RRNA1
- D) tRNA, rRNA and others are not transcribed. (easynotecards.com)
Isoleucine1
- Catalyzes the attachment of isoleucine to tRNA(Ile). (string-db.org)
Catalyse1
- En biochimie , une ligase est une enzyme qui catalyse la jonction de deux molécules (en anglais ligation ) par de nouvelles liaisons covalentes avec hydrolyse concomitante de l' ATP ou d'autres molécules similaires. (wikipedia.org)
Biosynthesis1
- Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. (cusabio.com)
Acceptor1
- Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). (string-db.org)
Synthase1
- En fait la synthase forme et défait les doubles liaisons d'une protéine. (wikipedia.org)
Leucyl1
- This domain is found methionyl, valyl, leucyl and isoleucyl tRNA synthetases. (embl.de)
Hydrolysis1
- One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. (string-db.org)
Activity1
- Replacement of individual amino acids of the 3His/1Glu metal binding motif by alanine drastically reduced or abolished quercetinase activity and affected its structural integrity. (biomedcentral.com)
Enzyme2
- An enzyme that activates alanine with its specific transfer RNA. (bvsalud.org)
- In fact, the origins of the word "Enzyme" derive from Greek: "en" (in) and "zyme" (ferment). (amano-enzyme.com)
Serine1
- Serine that is misactivated by AlaRS is captured by the lysine side chains of ANKRD16, which prevents the charging of serine adenylates to tRNA Ala and precludes serine misincorporation in nascent peptides. (elsevier.com)
Glutamine1
- EC 6.3.5 Carbone-Azote Ligases avec Glutamine comme Amido-N-Donneur. (wikipedia.org)
Involves1
- However, tRNA binding involves an alpha-helical structure that is conserved between class I and class II synthetases. (embl.de)
Reactions1
- L-alanine = 499 reactions were found. (tu-bs.de)
Class II1
- Class II tRNA synthases evolved early in evolution and are highly conserved. (genomics-online.com)
Process1
- As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. (string-db.org)
Synthetase13
- CDC64 encodes cytoplasmic alanyl-tRNA synthetase, Ala1p, of Saccharomyces cerevisiae. (tamu.edu)
- We report that CDC64 encodes Ala1p, an alanyl-tRNA synthetase. (tamu.edu)
- The protein encoded by this gene belongs to the class-II aminoacyl-tRNA synthetase family. (nih.gov)
- Protein biosynthesis.aminoacyl-tRNA synthetase. (ntu.edu.sg)
- threonyl-tRNA synthetase, putative / threonine--tRNA. (ntu.edu.sg)
- Sequence and structural studies show that two highly conserved amino acid residues, Asp and Asn, in the tRNA-binding domain of alanyl-tRNA synthetase (AlaRS) are responsible for recognition of the canonical identity elements G3:U70. (ncu.edu.tw)
- This domain is found at the amino terminus of Arginyl tRNA synthetase, also called additional domain 1 (Add-1). (embl.de)
- Crystal structure of arginyl-tRNA synthetase from Klebsiella pneumoniae subsp. (embl.de)
- Mutations in the nuclear encoded mitochondrial arginyl- tRNA synthetase gene underlie PCH6. (biomedcentral.com)
- The tRNA splicing endonuclease, the mitochondrial arginyl- tRNA synthetase and the vaccinia related kinase1 are mutated in the minority of PCH1 cases. (biomedcentral.com)
- In this review we describe the neuroradiological, neuropathological, clinical and genetic features of the different PCH subtypes and we report on in vitro and in vivo studies on the tRNA splicing endonuclease and mitochondrial arginyl-tRNA synthetase and discuss their relation to pontocerebellar hypoplasia. (biomedcentral.com)
- Ito, K., Kawakami, K., and Nakamura, Y. (1993) Multiple control of Escherichia coli lysyl-tRNA synthetase expression involves a transcriptional repressor and a translational enhancer element. (zfin.org)
- Nakamura, Y., and Kawakami, K. (1992) Overproduction and purification of lysyl-tRNA synthetase encoded by the herC gene of Escherichia coli. (zfin.org)
Mitochondrial1
- The encoded protein is a mitochondrial enzyme that specifically aminoacylates alanyl-tRNA. (nih.gov)
Subunit2
- In ltn1∆ mutant cells, Rqc2 engages the stalled nascent chain, and recruits tRNAs charged with alanine and threonine, so that the 60S catalyzes the C-terminal addition of alanine and threonine to the nascent chain (a "CAT-tail") in an unusual reaction that is not dependent on either the 40S subunit or mRNA 12 . (nature.com)
- Mutations in three tRNA splicing endonuclease subunit genes were found to be responsible for PCH2, PCH4 and PCH5. (biomedcentral.com)
Cysteine-tRNA l1
- EC 6.1.1.28: proline/cysteine-tRNA ligase. (wikibedia.ru)
Aminoacyl-tRNA synthe4
- Aminoacyl-tRNA synthetases play critical roles in mRNA translation by charging tRNAs with their cognate amino acids. (nih.gov)
- Aminoacyl-tRNA synthetases (aaRSs) are a family of translation enzymes, each of which catalyzes the attachment of a specific amino acid to its cognate tRNAs. (ncu.edu.tw)
- The 20 aminoacyl-tRNA synthetases are divided into two classes, I and II. (embl.de)
- In reactions catalysed by the class I aminoacyl-tRNA synthetases, the aminoacyl group is coupled to the 2'-hydroxyl of the tRNA, while, in class II reactions, the 3'-hydroxyl site is preferred. (embl.de)
AaRS2
- Each tRNA is recognized by its cognate aaRS through a specific set of "identity elements", which often reside in the acceptor stem and anticodon. (ncu.edu.tw)
- In contrast to DTD1, deacylates L-Ala mischarged on tRNA(Thr)(G4.U69) by alanine-tRNA ligase AARS (PubMed:29410408). (nih.gov)
Diphthine-ammoni1
- EC 6.3.2.22: Now EC 6.3.1.14 , diphthine-ammonia ligase. (wikibedia.ru)
Aminoacylation1
- For example, almost all known alanine tRNA (tRNAAla) isoacceptors contain a G3:U70 wobble base pair in the acceptor stem that identifies tRNAAla for aminoacylation with alanine. (ncu.edu.tw)
Histidine3
- Histidine-tRNA Ligase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (ouhsc.edu)
- This graph shows the total number of publications written about "Histidine-tRNA Ligase" by people in this website by year, and whether "Histidine-tRNA Ligase" was a major or minor topic of these publications. (ouhsc.edu)
- Below are the most recent publications written about "Histidine-tRNA Ligase" by people in Profiles. (ouhsc.edu)
Cognate1
- This raised the question of how AARS2 recognizes its cognate tRNA. (ncu.edu.tw)
Ubiquitin ligase1
- Here we report that ubiquitination of the 40S ribosomal protein uS10 by the E3 ubiquitin ligase Hel2 (or RQT1) is required for RQC. (nature.com)
Synthetases2
- However, tRNA binding involves an alpha-helical structure that is conserved between class I and class II synthetases. (embl.de)
- Kawakami, K., Ito, K., and Nakamura, Y. (1992) Differential regulation of two genes encoding lysyl-tRNA synthetases in Escherichia coli: lysU-constitutive mutations compensate for a lysS null mutation. (zfin.org)
Genes4
- Five rRNA operons and 74 tRNA genes constitute a total of 89 RNA genes leaving 4,953 protein-encoding genes (CDS). (atm-signaling.com)
- D. hafniense DZNeP in vivo Y51 contains six rRNA operons and 59 tRNA genes, and has a slightly larger genome by 448 kb (8.5% of the DCB-2 genome) with 166 more genes [9]. (atm-signaling.com)
- A download Französisches und Deutsches of required genes combine been trained to approach to the target in a tRNA and UNC119B: ARL3: ubiquitin turn. (evakoch.com)
- These genes are involved in essential processes in protein synthesis in general and tRNA processing in particular. (biomedcentral.com)
Ribosome1
- Cryo-electron microscopy analysis reveals that Hel2-bound ribosome are dominantly the rotated form with hybrid tRNAs. (nature.com)
Attachment1
- Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. (nih.gov)
Proteins4
- There are 26085 Arg_tRNA_synt_N domains in 26083 proteins in SMART's nrdb database. (embl.de)
- Taxonomic distribution of proteins containing Arg_tRNA_synt_N domain. (embl.de)
- The complete taxonomic breakdown of all proteins with Arg_tRNA_synt_N domain is also avaliable . (embl.de)
- Click on the protein counts, or double click on taxonomic names to display all proteins containing Arg_tRNA_synt_N domain in the selected taxonomic class. (embl.de)
Catalyzes1
- Catalyzes the hydrolysis of D-tyrosyl-tRNA(Tyr), has no activity on correctly charged L-tyrosyl-tRNA(Tyr) (By similarity). (nih.gov)