Alanine Transaminase
Aspartate Aminotransferases
Alanine
Liver
4-Aminobutyrate Transaminase
Drug-Induced Liver Injury
Transaminases
Liver Function Tests
D-Alanine Transaminase
Carbon Tetrachloride
gamma-Glutamyltransferase
Protective Agents
Plant Extracts
Acetaminophen
Liver Cirrhosis
Alkaline Phosphatase
Liver Cirrhosis, Experimental
Fatty Liver
Alanine Racemase
Biological Markers
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
Hepatitis B, Chronic
L-Lactate Dehydrogenase
Reperfusion Injury
Analgesics, Non-Narcotic
Rats, Wistar
Lipid Peroxidation
Thiobarbituric Acid Reactive Substances
Hepatitis C, Chronic
Tyrosine Transaminase
An enzyme that catalyzes the conversion of L-TYROSINE and 2-oxoglutarate to 4-hydroxyphenylpyruvate and L-GLUTAMATE. It is a pyridoxal-phosphate protein. L-PHENYLALANINE is hydroxylated to L-tyrosine. The mitochondrial enzyme may be identical with ASPARTATE AMINOTRANSFERASES (EC 2.6.1.1.). Deficiency of this enzyme may cause type II Tyrosinemia (see TYROSINEMIAS). EC 2.6.1.5.
Antioxidants
Necrosis
The pathological process occurring in cells that are dying from irreparable injuries. It is caused by the progressive, uncontrolled action of degradative ENZYMES, leading to MITOCHONDRIAL SWELLING, nuclear flocculation, and cell lysis. It is distinct it from APOPTOSIS, which is a normal, regulated cellular process.
Rats, Sprague-Dawley
Antiviral Agents
Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly.
Hepatitis C
INFLAMMATION of the LIVER in humans caused by HEPATITIS C VIRUS, a single-stranded RNA virus. Its incubation period is 30-90 days. Hepatitis C is transmitted primarily by contaminated blood parenterally, and is often associated with transfusion and intravenous drug abuse. However, in a significant number of cases, the source of hepatitis C infection is unknown.
Disease Models, Animal
Interferon-alpha
One of the type I interferons produced by peripheral blood leukocytes or lymphoblastoid cells. In addition to antiviral activity, it activates NATURAL KILLER CELLS and B-LYMPHOCYTES, and down-regulates VASCULAR ENDOTHELIAL GROWTH FACTOR expression through PI-3 KINASE and MAPK KINASES signaling pathways.
Treatment Outcome
Alanine Dehydrogenase
An NAD-dependent enzyme that catalyzes the reversible DEAMINATION of L-ALANINE to PYRUVATE and AMMONIA. The enzyme is needed for growth when ALANINE is the sole CARBON or NITROGEN source. It may also play a role in CELL WALL synthesis because L-ALANINE is an important constituent of the PEPTIDOGLYCAN layer.
Hepacivirus
Ornithine-Oxo-Acid Transaminase
Aminooxyacetic Acid
Vigabatrin
Predictive Value of Tests
In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.
beta-Alanine-Pyruvate Transaminase
Retrospective Studies
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Amino Acids
Pyridoxal Phosphate
This is the active form of VITAMIN B 6 serving as a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. During transamination of amino acids, pyridoxal phosphate is transiently converted into pyridoxamine phosphate (PYRIDOXAMINE).
Tumor Necrosis Factor-alpha
Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.
Isoleucine
Prospective Studies
Ketoglutaric Acids
Amino Acid Sequence
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Aminobutyrates
Clinical Enzyme Tests
Pyridoxine
The 4-methanol form of VITAMIN B 6 which is converted to PYRIDOXAL PHOSPHATE which is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. Although pyridoxine and Vitamin B 6 are still frequently used as synonyms, especially by medical researchers, this practice is erroneous and sometimes misleading (EE Snell; Ann NY Acad Sci, vol 585 pg 1, 1990).
Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing)
Mutagenesis, Site-Directed
Glycine Transaminase
Glutamine
Aspartic Acid
Glutamates
Mutation
Succinyldiaminopimelate Transaminase
Pyridoxamine
Lyases
Valine
Escherichia coli
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.
Amination
Succinate-Semialdehyde Dehydrogenase
An enzyme that plays a role in the GLUTAMATE and butanoate metabolism pathways by catalyzing the oxidation of succinate semialdehyde to SUCCINATE using NAD+ as a coenzyme. Deficiency of this enzyme, causes 4-hydroxybutyricaciduria, a rare inborn error in the metabolism of the neurotransmitter 4-aminobutyric acid (GABA).
Amino Acid Substitution
The naturally occurring or experimentally induced replacement of one or more AMINO ACIDS in a protein with another. If a functionally equivalent amino acid is substituted, the protein may retain wild-type activity. Substitution may also diminish, enhance, or eliminate protein function. Experimentally induced substitution is often used to study enzyme activities and binding site properties.
Oxaloacetic Acid
Aminocaproates
Serine
Substrate Specificity
Quantitative aspects in the assessment of liver injury. (1/3443)
Liver function data are usually difficult to use in their original form when one wishes to compare the hepatotoxic properties of several chemical substances. However, procedures are available for the conversion of liver function data into quantal responses. These permit the elaboration of dose-response lines for the substances in question, the calculation of median effective doses and the statistical analysis of differences in liver-damaging potency. These same procedures can be utilized for estimating the relative hazard involved if one compares the liver-damaging potency to the median effective dose for some other pharmacologie parameter. Alterations in hepatic triglycerides, lipid peroxidation, and the activities of various hepatic enzymes can also be quantitiated in a dose-related manner. This permits the selection of equitoxic doses required for certain comparative studies and the selection of doses in chemical interaction studies. The quantitative problems involved in low-frequency adverse reactions and the difficulty these present in the detection of liver injury in laboratory animals are discussed. (+info)Activities of citrate synthase, NAD+-linked and NADP+-linked isocitrate dehydrogenases, glutamate dehydrogenase, aspartate aminotransferase and alanine aminotransferase in nervous tissues from vertebrates and invertebrates. (2/3443)
1. The activities of citrate synthase and NAD+-linked and NADP+-linked isocitrate dehydrogenases were measured in nervous tissue from different animals in an attempt to provide more information about the citric acid cycle in this tissue. In higher animals the activities of citrate synthase are greater than the sum of activities of the isocitrate dehydrogenases, whereas they are similar in nervous tissues from the lower animals. This suggests that in higher animals the isocitrate dehydrogenase reaction is far-removed from equilibrium. If it is assumed that isocitrate dehydrogenase activities provide an indication of the maximum flux through the citric acid cycle, the maximum glycolytic capacity in nervous tissue is considerably greater than that of the cycle. This suggest that glycolysis can provide energy in excess of the aerobic capacity of the tissue. 2. The activities of glutamate dehydrogenase are high in most nervous tissues and the activities of aspartate aminotransferase are high in all nervous tissue investigated. However, the activities of alanine aminotransferase are low in all tissues except the ganglia of the waterbug and cockroach. In these insect tissues, anaerobic glycolysis may result in the formation of alanine rather than lactate. (+info)Blockade of type beta transforming growth factor signaling prevents liver fibrosis and dysfunction in the rat. (3/3443)
We eliminated type beta transforming growth factor (TGF-beta) signaling by adenovirus-mediated local expression of a dominant-negative type II TGF-beta receptor (AdCATbeta-TR) in the liver of rats treated with dimethylnitrosamine, a model of persistent liver fibrosis. In rats that received a single application of AdCATbeta-TR via the portal vein, liver fibrosis as assessed by histology and hydroxyproline content was markedly attenuated. All AdCATbeta-TR-treated rats remained alive, and their serum levels of hyaluronic acid and transaminases remained at low levels, whereas all the AdCATbeta-TR-untreated rats died of liver dysfunction. The results demonstrate that TGF-beta does play a central role in liver fibrogenesis and indicate clearly in a persistent fibrosis model that prevention of fibrosis by anti-TGF-beta intervention could be therapeutically useful. (+info)Phase I and pharmacokinetic study of the topoisomerase II catalytic inhibitor fostriecin. (4/3443)
We conducted a phase I and pharmacokinetic study of the topoisomerase II catalytic inhibitor fostriecin. Fostriecin was administered intravenously over 60 min on days 1-5 at 4-week intervals. Dose was escalated from 2 mg m(-2) day(-1) to 20 mg m(-2) day(-1) in 20 patients. Drug pharmacokinetics was analysed with high performance liquid chromatography with UV-detection. Plasma collected during drug administration was tested in vitro for growth inhibition of a teniposide-resistant small-cell lung cancer (SCLC) cell line. The predominant toxicities were elevated liver transaminases (maximum common toxicity criteria (CTC) grade 4) and serum creatinine (maximum CTC grade 2). These showed only a limited increase with increasing doses, often recovered during drug administration and were fully reversible. Duration of elevated alanine-amino transferase (ALT) was dose-limiting in one patient at 20 mg m(-2). Other frequent toxicities were grade 1-2 nausea/vomiting, fever and mild fatigue. Mean fostriecin plasma half-life was 0.36 h (initial; 95% CI, 0-0.76 h) and 1.51 h (terminal; 95% CI, 0.41-2.61 h). A metabolite, most probably dephosphorylated fostriecin, was detected in plasma and urine. No tumour responses were observed, but the plasma concentrations reached in the patients were insufficient to induce significant growth inhibition in vitro. The maximum tolerated dose (MTD) has not been reached, because drug supply was stopped at the 20 mg m(-2) dose level. However, further escalation seems possible and is warranted to achieve potentially effective drug levels. Fostriecin has a short plasma half-life and longer duration of infusion should be considered. (+info)Influences of Kupffer cell stimulation and suppression on immunological liver injury in mice. (5/3443)
AIM: To study the possible involvement of Kupffer cells (KC) in immunological liver injury in mice. METHODS: Liver injury was induced by i.v. injection of Bacillus Calmette-Guerin (BCG) 5 x 10(7) viable bacilli followed by i.v. injection of lipopolysaccharides (LPS) 7.5 micrograms to each mouse. Indian ink and silica were i.v. injected to suppress KC and retinol was given po to stimulate KC in these mice. Plasma alanine aminotransferase (AlaAT), aspatate aminotransferase (AspAT), nitric oxide (NO), and liver tissue were examined. RESULTS: Injection of LPS following BCG injection resulted in a remarkable elevation of plasma NO, AlaAT, and AspAT levels, and severe liver damage. The damages were enhanced by the activation of KC with retinol and reduced by suppression of KC with silica and Indian ink. CONCLUSION: The degree of liver injury induced by BCG + LPS is closely correlated with the status of KC, and NO from KC plays an important role in the pathogenesis of the liver damage in mice. (+info)Effect of epidermal growth factor on cultured rat hepatocytes poisoned by CCl4. (6/3443)
AIM: To study the effects of epidermal growth factor (EGF) on CCl4-induced primary cultured hepatocytes injury. METHODS: Alanine amino-transferase (AlaAT) and aspartate aminotransferase (AspAT) activities and K+ concentractions were determined by the Auto-biochemistry Assay System. Malondialdehyde (MDA) was determined by thiobarbituric acid method. Radioactivity was determined by liquid scintillometry. Light microscopy and electron microscopy were used. RESULTS: EGF 40 micrograms.L-1 decreased CCl4 (10 mmol.L-1)-induced damages of rat primary cultured hepatocytes by decreasing AlaAT and AspAT leakage and MDA production, and promoted RNA and DNA synthesis, with a high positive correlation between intracellular K+ leakage and DNA syntheses (r = 0.99, P < 0.01). Cytopathological study showed that EGF decreased damage of liver cells. CONCLUSION: EGF maintains the stability of cellular lipid membrane and promotes syntheses of RNA and DNA of hepatocytes, and intracellular K+ transference is a promotor of the message transmission of DNA synthesis. (+info)Continuous versus intermittent portal triad clamping for liver resection: a controlled study. (7/3443)
OBJECTIVE: The authors compared the intra- and postoperative course of patients undergoing liver resections under continuous pedicular clamping (CPC) or intermittent pedicular clamping (IPC). SUMMARY BACKGROUND DATA: Reduced blood loss during liver resection is achieved by pedicular clamping. There is controversy about the benefits of IPC over CPC in humans in terms of hepatocellular injury and blood loss control in normal and abnormal liver parenchyma. METHODS: Eighty-six patients undergoing liver resections were included in a prospective randomized study comparing the intra- and postoperative course under CPC (n = 42) or IPC (n = 44) with periods of 15 minutes of clamping and 5 minutes of unclamping. The data were further analyzed according to the presence (steatosis >20% and chronic liver disease) or absence of abnormal liver parenchyma. RESULTS: The two groups of patients were similar in terms of age, sex, nature of the liver tumors, results of preoperative assessment, proportion of patients undergoing major or minor hepatectomy, and nature of nontumorous liver parenchyma. Intraoperative blood loss during liver transsection was significantly higher in the IPC group. In the CPC group, postoperative liver enzymes and serum bilirubin levels were significantly higher in the subgroup of patients with abnormal liver parenchyma. Major postoperative deterioration of liver function occurred in four patients with abnormal liver parenchyma, with two postoperative deaths. All of them were in the CPC group. CONCLUSIONS: This clinical controlled study clearly demonstrated the better parenchymal tolerance to IPC over CPC, especially in patients with abnormal liver parenchyma. (+info)Folate nutriture alters choline status of women and men fed low choline diets. (8/3443)
Choline and folate share methylation pathways and, in studies of rats, were shown to be metabolically inter-related. To determine whether choline status is related to folate intake in humans, we measured the effect of controlled folate depletion and repletion on the plasma choline and phosphatidylcholine concentrations of 11 healthy men (33-46 y) and 10 healthy women (49-63 y) fed low-choline diets in two separate metabolic unit studies. Total folate intake was varied by supplementing low folate (25 and 56 microg/d for men and women, respectively) and low choline (238 and 147 mg/d for men and women, respectively) diets with pteroylglutamic acid for 2-6 wk following folate-depletion periods of 4-5 wk. The low folate/choline intakes resulted in subclinical folate deficiencies; mean plasma choline decreases of 28 and 25% in the men and women, respectively; and a plasma phosphatidylcholine decrease of 26% in the men (P < 0. 05). No functional choline deficiency occurred, as measured by serum transaminase and lipid concentrations. The decreases in choline status measures returned to baseline or higher upon moderate folate repletion and were more responsive to folate repletion than plasma folate and homocysteine. Feeding methionine supplements to the men did not prevent plasma choline depletion, indicating that folate is a more limiting nutrient for these methylation pathways. The results indicate that 1) choline is utilized as a methyl donor when folate intake is low, 2) the de novo synthesis of phosphatidylcholine is insufficient to maintain choline status when intakes of folate and choline are low, and 3) dietary choline is required by adults in an amount > 250 mg/d to maintain plasma choline and phosphatidylcholine when folate intake is low. (+info)
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Lactate dehydrogenase
from alanine (Alanine cycle):. *Alanine transaminase. from glycerol:. *Glycerol kinase. *Glycerol dehydrogenase ... Alanine and lactate are major gluconeogenic precursors that enter gluconeogenesis as pyruvate. The high NADH/NAD+ ratio shifts ... The noticeable difference between the two subunits that make up LDH's tertiary structure is the replacement of alanine (in the ...
Glucose 6-phosphatase
from alanine (Alanine cycle):. *Alanine transaminase. from glycerol:. *Glycerol kinase. *Glycerol dehydrogenase ...
Glutamine synthetase
Alanine, glycine, and serine bind to the glutamate substrate site. GDP, AMP, ADP bind to the ATP site.[6] L-serine, L-alanine, ... "Feedback inhibition of fully unadenylylated glutamine synthetase from Salmonella typhimurium by glycine, alanine, and serine" ... Other inhibitors/regulators are glycine and alanine. ... alanine→. *Alanine transaminase. cysteine→. *D-cysteine ...
Kynureninase
... alanines. Humans express one kynureninase enzyme that is encoded by the KYNU gene located on chromosome 2.[6][7] ... Aspartate transaminase. *Glutamate dehydrogenase. *Pyruvate dehydrogenase complex. urea cycle. *Carbamoyl phosphate synthetase ...
Glycine cleavage system
alanine→. *Alanine transaminase. cysteine→. *D-cysteine desulfhydrase. threonine→. *L-threonine dehydrogenase. G→glutamate→. α- ...
PFKFB2
from alanine (Alanine cycle):. *Alanine transaminase. from glycerol:. *Glycerol kinase. *Glycerol dehydrogenase ...
Cori cycle
from alanine (Alanine cycle):. *Alanine transaminase. from glycerol:. *Glycerol kinase. *Glycerol dehydrogenase ... pyruvate and alanine, lead to excess lactate.[9] Normally, the excess lactate would be cleared by the kidneys, but in patients ...
Amino acid synthesis
... undergoes transamination catalyzed either by an alanine-valine transaminase or a glutamate-valine transaminase. Valine ... Alanine[edit]. Alanine is produced by the transamination of one molecule of pyruvate using two alternate steps: 1) conversion ... Pyruvate: alanine, valine, and leucine[edit]. Pyruvate, the end result of glycolysis, can feed into both the TCA cycle and ... Alanine and aspartate are synthesized by the transamination of pyruvate and oxaloacetate, respectively. Glutamine is ...
Creatine kinase
Aspartate transaminase. *Glutamate dehydrogenase. *Pyruvate dehydrogenase complex. urea cycle. *Carbamoyl phosphate synthetase ...
L-DOPA
alanine→. *Alanine transaminase. cysteine→. *D-cysteine desulfhydrase. threonine→. *L-threonine dehydrogenase. G→glutamate→. α- ...
Pyruvic acid
Transamination by alanine transaminase produces alanine. Reduction by lactate dehydrogenase produces lactate. Pyruvate is sold ... It can also be used to construct the amino acid alanine and can be converted into ethanol or lactic acid via fermentation. ... to the amino acid alanine, and to ethanol. Therefore, it unites several key metabolic processes. In glycolysis, ...
Bonny Light oil
aspartate transaminase (AST) and alanine transaminase (ALT) concentrations rose too. Fishes which are exposed to crude oil get ...
Cefovecin
Mildly increased serum alanine transaminase (ALT) and gamma-glutamyltransferase may also occur. Other reported events in dogs ...
Ribociclib
16%). The drug also increases the QT interval and liver enzymes (alanine transaminase, aspartate transaminase). As ribociclib ...
Dicarboxylic aminoaciduria
Below is an example of how glutamate is used to synthesize alanine via alanine transaminase. Glutamate + pyruvate ⇌ α- ... ketoglutarate + Alanine Another example is the conversion of aspartate to glutamate via the enzyme aspartate transaminase. ... In the case of dicarboxylic aminoaciduria, where glutamate and aspartate transport are impaired, the alanine, aspartate and ...
Grazoprevir
The most important risks are alanine transaminase elevation, hyperbilirubinemia, drug resistance development and drug ...
Liver disease
serum proteins, serum albumin, serum globulin, alanine transaminase, aspartate transaminase, prothrombin time, partial ...
Phenelzine
... of which are alanine transaminase (ALA-T), and γ-Aminobutyric acid transaminase (GABA-T), the latter of which is not caused by ... "Effects of the antidepressant/antipanic drug phenelzine on alanine and alanine transaminase in rat brain". Cellular and ... Transaminases such as GABA-transaminase have been shown to be dependent upon vitamin B6 and may be involved in a potentially ... phenelzine causes an increase in the alanine and GABA levels in the brain and body. GABA is the major inhibitory ...
Primary hyperoxaluria
Vitamin B6 (pyridoxine) is used for primary hyperoxaluria type1 as alanine glyoxylate transaminase require pyridoxine as ...
Hepatic artery thrombosis
... alanine transaminase (ALT) and aspartate transaminase (AST). Often the AST is greater than the ALT. Hepatic artery thrombosis ...
Ruxolitinib
Laboratory abnormalities have included alanine transaminase (ALT) abnormalities, aspartate transaminase (AST) abnormalities, ...
Entecavir
Laboratory tests may show an increase in alanine transaminase (ALT), hematuria, glycosuria, and an increase in lipase. Periodic ...
Pirfenidone
... can increase hepatic enzyme levels, especially those of aspartate transaminase, alanine transaminase and gamma- ...
Wilson's disease
Most have slightly abnormal liver function tests such as a raised aspartate transaminase, alanine transaminase and bilirubin ...
Tocilizumab
The enzyme alanine transaminase was also elevated in at least 5% of patients, but in most cases without symptoms. Elevated ... medications used in the treatments during the study were found to be associated with peak hospitalization liver transaminase ...
TBC1D10A
... alanine transaminase and alkaline phosphatase levels. GRCh38: Ensembl release 89: ENSG00000099992 - Ensembl, May 2017 GRCm38: ...
Alpha-Ketoglutaric acid
The enzyme alanine transaminase converts α-ketoglutarate and L-alanine to L-glutamate and pyruvate, respectively, as a ...
HELLP syndrome
Elevated serum levels of certain proteins, in particular, LDH, alanine transaminase (ALT) and aspartate transaminase (AST), are ... an aspartate transaminase greater than 70 U/l, and platelets less than 100x109/l. If not all the criteria are present, the ...
Thioacetamide
... which include elevation in the levels of serum alanine transaminase, aspartate transaminase and aspartic acid. International ... Its administration in rat induces hepatic encephalopathy, metabolic acidosis, increased levels of transaminases, abnormal ...
Beta-alanine-pyruvate transaminase
Other names in common use include beta-alanine-pyruvate aminotransferase, and beta-alanine-alpha-alanine transaminase. This ... L-alanine + 3-oxopropanoate ⇌. {\displaystyle \rightleftharpoons }. pyruvate + beta-alanine. Thus, the two substrates of this ... In enzymology, a beta-alanine-pyruvate transaminase (EC 2.6.1.18) is an enzyme that catalyzes the chemical reaction ... Stinson RA, Spencer MS (1969). "Beta alanine aminotransferase (s) from a plant source". Biochem. Biophys. Res. Commun. 34 (1): ...
Glutamate decarboxylase
Inhibitors: β-Alanine. *Bafilomycin A1. *Chicago sky blue 6B. *Evans blue. *GABA ...
Telcagepant
... locations stated that telcagepant had preliminarily been reported to increase the hepatic liver enzyme alanine transaminase ( ... "identification of two patients with significant elevations in serum transaminases".[4] A memo to study ...
Biyokimika, ang malayang ensiklopedya
Ang mga mamalya ay mayroong mga ensimas upang makagawa ng alanine, asparagine, aspartate, cysteine, glutamate, glutamine, ... Ang mga ensimang tinatawag na mga transaminasas (transaminases) ay madaling makapaglilipat ng grupong amino mula sa isang asido ... "alanine-glycine-tryptophan-serine-glutamate-asparagine-glycine-lysine-...". Ang sekundaryong estruktura ay nauukol sa lokal na ...
Hepatotoxicity
An elevation in serum bilirubin level of more than 2 times ULN with associated transaminase rise is an ominous sign. This ... Biochemical markers (e.g. alanine transferase, alkaline phosphatase and bilirubin) are often used to indicate liver damage. ... Arora N, Goldhaber SZ (2006). "Anticoagulants and transaminase elevation". Circulation. 113 (15): e698-702. doi:10.1161/ ... predominantly initial Alanine transferase elevation) and cholestatic (initial alkaline phosphatase rise) types. However they ...
Elbasvir/grazoprevir
The most important risks are Alanine transaminase elevation, hyperbilirubinemia, drug resistance development and drug ...
Glutamic acid
Alanine + α-ketoglutarate ⇌ pyruvate + glutamate. Aspartate + α-ketoglutarate ⇌ oxaloacetate + glutamate. Both pyruvate and ... typically catalysed by a transaminase. The reaction can be generalised as such: R1-amino acid + R2-α-ketoacid ⇌ R1-α-ketoacid ...
Gynecomastia
... investigations to find the underlying cause of gynecomastia include tests for aspartate transaminase and alanine transaminase ...
Citric acid cycle
De-aminated alanine, cysteine, glycine, serine, and threonine are converted to pyruvate and can consequently either enter the ... intra-mitochondrial oxaloacetate is an early step in the gluconeogenic pathway which converts lactate and de-aminated alanine ...
gamma-Aminobutyric acid
GABA transaminase inhibitors: gabaculine, phenelzine, valproate, vigabatrin, lemon balm (Melissa officinalis).[76] ... GABA transaminase enzymes catalyze the conversion of 4-aminobutanoic acid (GABA) and 2-oxoglutarate (α-ketoglutarate) into ... transaminase genes in plants or Pseudomonas syringae reduce bacterial virulence". Plant J. 64 (2): 318-30. doi:10.1111/j.1365- ... 4-aminobutyrate transaminase (GABA-transaminase) deficiency. Notes[edit]. .mw-parser-output .reflist{font-size:90%;margin- ...
Valpromide
Inhibitors: β-Alanine. *Bafilomycin A1. *Chicago sky blue 6B. *Evans blue. *GABA ...
Enzyme promiscuity
An example of a commonly evolved enzyme is ω-transaminase which can replace a ketone with a chiral amine[32] and consequently ... β-cyclohexyl-L-alanine, 4-amino-L-phenylalanine and L-norleucine.[28] ... Shin JS, Kim BG (August 2001). "Comparison of the omega-transaminases from different microorganisms and application to ...
Biochemistry
Enzymes called transaminases can easily transfer the amino group from one amino acid (making it an α-keto acid) to another α- ... Mammals do possess the enzymes to synthesize alanine, asparagine, aspartate, cysteine, glutamate, glutamine, glycine, proline, ... The primary structure of a protein simply consists of its linear sequence of amino acids; for instance, "alanine-glycine- ...
Oxaloacetic acid
Six essential amino acids and three nonessential are synthesized from oxaloacetate and pyruvate.[5] Aspartate and alanine are ... After that, oxaloacetate will be recycled to aspartate, as transaminases prefer these keto acids over the others. This ...
Elevated transaminases
The two transaminases commonly measured are alanine transaminase (ALT) and aspartate transaminase (AST).[1] These levels ... Alanine transaminase is one of the two transaminases measured (Aspartate transaminase is the other).. ... In medicine, the presence of elevated transaminases, commonly the transaminases alanine transaminase (ALT) and aspartate ... Elevated transaminases that persist less than six months are termed "acute" in nature, and those values that persist for six ...
Transamination
The products usually are either alanine, aspartate or glutamate, since their corresponding alpha-keto acids are produced ... Transamination in biochemistry is accomplished by enzymes called transaminases or aminotransferases. α-ketoglutarate acts as ... The two common types of aminotransferases are Alanine aminotransferase (ALT) and Aspartate aminotransferase (AST). ...
AGXT - Wicipedia
alanine-glyoxylate transaminase activity. • serine-pyruvate transaminase activity. • transaminase activity. • protein self- ... AGXT, AGT, AGT1, AGXT1, PH1, SPAT, SPT, TLH6, alanine-glyoxylate aminotransferase, alanine--glyoxylate and serine--pyruvate ... L-alanine catabolic process. • response to glucocorticoid. • response to cAMP. • L-cysteine catabolic process. • cellular ... "Effects of interface mutations on the dimerization of alanine glyoxylate aminotransferase and implications in the mistargeting ...
Ascending cholangitis
... with elevations in alanine transaminase and aspartate transaminase.[1] Blood cultures are often performed in people with fever ...
Bilirubin
... especially the enzymes alanine transaminase, aspartate transaminase, gamma-glutamyl transpeptidase, alkaline phosphatase), ...
Alanine transaminase
Redirected from Alanine aminotransferase). Alanine transaminase (ALT) is a transaminase enzyme (EC 2.6.1.2). It is also called ... It catalyzes the two parts of the alanine cycle. Serum ALT level, serum AST (aspartate transaminase) level, and their ratio ( ... Alanine+transaminase at the US National Library of Medicine Medical Subject Headings (MeSH) ... Alanine transaminase shows a marked diurnal variation.[citation needed]. The AST/ALT ratio (with AST being aspartate ...
Beta-alanine-pyruvate transaminase - Wikipedia
Other names in common use include beta-alanine-pyruvate aminotransferase, and beta-alanine-alpha-alanine transaminase. This ... L-alanine + 3-oxopropanoate ⇌. {\displaystyle \rightleftharpoons }. pyruvate + beta-alanine. Thus, the two substrates of this ... In enzymology, a beta-alanine-pyruvate transaminase (EC 2.6.1.18) is an enzyme that catalyzes the chemical reaction ... Stinson RA, Spencer MS (1969). "Beta alanine aminotransferase (s) from a plant source". Biochem. Biophys. Res. Commun. 34 (1): ...
Alanine transaminase (ALT) blood test: MedlinePlus Medical Encyclopedia
The alanine transaminase (ALT) blood test measures the level of the enzyme ALT in the blood. ... Alanine aminotransferase (ALT, alanine transaminase, SGPT) - serum. In: Chernecky CC, Berger BJ, eds. Laboratory Tests and ... The alanine transaminase (ALT) blood test measures the level of the enzyme ALT in the blood. ... Alanine transaminase (ALT) blood test. URL of this page: //medlineplus.gov/ency/article/003473.htm Alanine transaminase (ALT) ...
Alanine transaminase - Wikipedia
Alanine transaminase (ALT) is a transaminase enzyme (EC 2.6.1.2). It is also called alanine aminotransferase (ALAT) and was ... Alanine+transaminase at the US National Library of Medicine Medical Subject Headings (MeSH) ALT: analyte monograph; The ... It catalyzes the two parts of the alanine cycle. Serum ALT level, serum AST (aspartate transaminase) level, and their ratio ( ... The term transaminase is outdated and no longer used in liver disease. Aspartate transaminase Liver function tests Karmen A, ...
Alanine-oxomalonate transaminase - Wikipedia
Other names in common use include alanine-oxomalonate aminotransferase, L-alanine-ketomalonate transaminase, and alanine- ... In enzymology, an alanine-oxomalonate transaminase (EC 2.6.1.47) is an enzyme that catalyzes the chemical reaction L-alanine + ... This enzyme belongs to the family of transferases, specifically the transaminases, which transfer nitrogenous groups. The ... ketomalonate (mesoxalate) transaminase. It employs one cofactor, pyridoxal phosphate. Nagayama H, Muramatsu M, Shimura K (1958 ...
Alanine transaminase - Wikipedia
Redirected from Alanine aminotransferase). Alanine transaminase (ALT) is a transaminase enzyme (EC 2.6.1.2). It is also called ... It catalyzes the two parts of the alanine cycle. Serum ALT level, serum AST (aspartate transaminase) level, and their ratio ( ... Alanine+transaminase at the US National Library of Medicine Medical Subject Headings (MeSH) ... Alanine transaminase shows a marked diurnal variation.[citation needed]. The AST/ALT ratio (with AST being aspartate ...
Anti-Alanine Transaminase antibody (ab34832) | Abcam
Sheep polyclonal Alanine Transaminase antibody. Validated in WB, IP, ELISA, Dot and tested in Pig. Immunogen corresponding to ... Amino-acid degradation; L-alanine degradation via transaminase pathway; pyruvate from L-alanine: step 1/1. ... Protein - Recombinant mouse Alanine Transaminase protein (Active) (ab222953) MS, Functional Studies, SDS-PAGE ... Primary - Sheep Anti-Alanine Transaminase antibody (ab34832) Dot blot, WB, ELISA, IP ...
ALANINE TRANSAMINASE (ALT), SERUM
Recombinant Human Alanine Transaminase protein (ab113862) References
decreased circulating alanine transaminase level Mammalian Phenotype Term (MP:0002942)
The Mammalian Phenotype (MP) Ontology is a community effort to provide standard terms for annotating phenotypic data. You can use this browser to view terms, definitions, and term relationships in a hierarchical display. Links to summary annotated phenotype data at MGI are provided in Term Detail reports.
Alanine transaminase | definition of alanine transaminase by Medical dictionary
What is alanine transaminase? Meaning of alanine transaminase medical term. What does alanine transaminase mean? ... Looking for online definition of alanine transaminase in the Medical Dictionary? alanine transaminase explanation free. ... Synonym(s): alanine transaminase, glutamic-pyruvic transaminase, serum glutamic:pyruvic transaminase. alanine transaminase. /al ... Related to alanine transaminase: Aspartate transaminase. alanine transaminase. [al´ah-nēn trans-am´ĭ-nās] an enzyme that ...
WikiGenes - Gpt - glutamic-pyruvate transaminase (alanine...
Synonyms: ALT1, Aat1, Alanine aminotransferase 1, GPT 1, Glutamate pyruvate transaminase 1, ... ... 3. The increase in alanine metabolism on high-protein diets was associated with an increase in alanine aminotransferase and in ... Glutamic oxalacetic transaminase, glutamic pyruvic transaminase, and guanase activities were found to be significantly elevated ... Serum enzymes, creatine phosphokinase, serum glutamic oxalo-pyruvic transaminase, serum glutamic pyruvic transaminase, lactate ...
Three Stars Medical Supplies - Alanine transaminase Manufacturer & Exporters
Clinical, histological, and virological features of hepatitis C virus carriers with persistently normal or abnormal alanine...
... and virological features of hepatitis C virus carriers with persistently normal or abnormal alanine transaminase levels. ... and virological features of hepatitis C virus carriers with persistently normal or abnormal alanine transaminase levels. ... Assessment of liver function in patients with hepatitis C and normal transaminase levels. Eur J Gastroenterol Hepatol 1996; 8: ... Liver histology in hepatitis C infection: a comparison between patients with persistently normal or abnormal transaminases. Gut ...
Hepatitis C virus infection and alanine transaminase levels in the general population: a survey in a southern Italian town
Frontiers | Peptide Bond Formation Between the Hetrosubunits of ω-Transaminase, Alanine Dehydrogenase, and Formate...
... alanine dehydrogenase (AlaDH), and formate dehydrogenase (FDH), peptide bond formation between the hetrosubunits has been ... alanine dehydrogenase (AlaDH), and formate dehydrogenase (FDH), peptide bond formation between the hetrosubunits has been ... For the multimeric enzymes R-ω-transaminase (RTA), ... For the multimeric enzymes R-ω-transaminase (RTA), ... R-ω-Transaminase (RTA) and alanine dehydrogenase (AlaDH) are dimeric enzymes, each consisting of two subunits. ZE was fused to ...
Improved Performance of Serum Alpha-Fetoprotein for Hepatocellular Carcinoma Diagnosis in HCV cirrhosis with Normal Alanine...
Results: HCV etiology, Non-White race, and serum alanine transaminase (ALT) predicted elevated AFP in cirrhotics. Non-White ... Performance of Serum Alpha-Fetoprotein for Hepatocellular Carcinoma Diagnosis in HCV cirrhosis with Normal Alanine Transaminase ... Performance of Serum Alpha-Fetoprotein for Hepatocellular Carcinoma Diagnosis in HCV cirrhosis with Normal Alanine Transaminase ... Performance of Serum Alpha-Fetoprotein for Hepatocellular Carcinoma Diagnosis in HCV cirrhosis with Normal Alanine Transaminase ...
Recombinant Human Glutamic-Pyruvate Transaminase/Alanine Aminotransferase Heart | Cell Sciences
Frontiers | Saccharomyces cerevisiae Differential Functionalization of Presumed ScALT1 and ScALT2 Alanine Transaminases Has...
Diversification analysis of ScAlt1/ScAlt2 indicated that while ScAlt1 is an alanine transaminase, ScAlt2 lost this activity, ... functional diversification could have determined loss of ScAlt2 alanine transaminase activity and thus its role in alanine ... functional diversification could have determined loss of ScAlt2 alanine transaminase activity and thus its role in alanine ... that could result in lack of alanine transaminase activity in ScAlt2. The fact that ScAlt2 forms a catalytically active Schiff ...
Anti-GPT / Alanine Transaminase Antibody | Rabbit anti-Human | LSBio
Alanine Transaminase antibody LS-C100675 is an unconjugated rabbit polyclonal antibody to human Alanine Transaminase (GPT ). ... Alanine Transaminase antibody LS-C100675 is an unconjugated rabbit polyclonal antibody to human Alanine Transaminase (GPT ). ... GPT / Alanine Transaminase Antibody (aa31‑80) LS‑C80760 Species: Human, Monkey, Mouse, Rat, Bat, Bovine, Dog, Guinea pig, ... GPT / Alanine Transaminase Antibody (aa86‑112) LS‑C100675 GPT / Alanine Transaminase Antibody (aa86‑112) LS‑C100675 ...
Anti-GPT / Alanine Transaminase Antibody | Rabbit anti-Rat WB | LSBio
Alanine Transaminase antibody LS-C292687 is an unconjugated rabbit polyclonal antibody to rat Alanine Transaminase (GPT ). ... Alanine Transaminase antibody LS-C292687 is an unconjugated rabbit polyclonal antibody to rat Alanine Transaminase (GPT ). ... GPT / Alanine Transaminase Antibody (aa31‑80) LS‑C80760 Species: Human, Monkey, Mouse, Rat, Bat, Bovine, Dog, Guinea pig, ... GPT / Alanine Transaminase Antibody (aa1‑496) LS‑C292687 GPT / Alanine Transaminase Antibody (aa1‑496) LS‑C292687 ...
AID 1106867 - Hepatoprotective activity against CCL4-induced toxicity in human HuH7 cells assessed as decrease in alanine...
HIE Multimedia - Alanine transaminase (ALT) blood test
Alanine transaminase (ALT) blood test. SGPT; Serum glutamate pyruvate transaminase; Alanine transaminase; Alanine ... Alanine aminotransferase (ALT, alanine transaminase, SGPT) - serum. In: Chernecky CC, Berger BJ, eds. Laboratory Tests and ... The alanine transaminase (ALT) blood test measures the level of the enzyme ALT in the blood.. Enzyme. Enzymes are complex ... Tests for Alanine transaminase (ALT) blood test. *Alanine transaminase (ALT) blood test ...
Metabolic Cause of Obesity: The Role of Alanine Transaminase in Increasing BMI, Cholesterol, Blood Pressure and Blood Glucose ...
The effectiveness of fermented turmeric powder in subjects with elevated alanine transaminase levels: a randomised controlled...
... on liver function in subjects with elevated alanine transaminase (ALT) levels. A randomised, double-blind, placebo-controlled ... The effectiveness of fermented turmeric powder in subjects with elevated alanine transaminase levels: a randomised controlled ... on liver function in subjects with elevated alanine transaminase (ALT) levels. ... Flow chart for the study subjects. AEs, adverse events; ALT, alanine aminotransferase; FTP, fermented turmeric powder; ITT, ...
alanine transaminase - oi
alanine transaminase can also refer to... alanine transaminase The Association of Alanine Transaminase With Aging, Frailty, ... pyruvic transaminase; glutamic‐alanine transaminase. An enzyme that catalyses the reversible reaction:. l‐alanine + 2‐ ... Fine Particle Pollution, Alanine Transaminase, and Liver Cancer: A Taiwanese Prospective Cohort Study (REVEAL-HBV) ... Elevated serum alanine transaminase in patients with type 1 or type 2 diabetes mellitus ...
Alanine Transaminase | Viapath
Cairoscan | Alanine Transaminase (ALT)
ALT (Alanine Transaminase) | Viapath
Alanine Transaminase (ALT/SGPT) - MolQ
Diagnosis and monitoring of liver disease associated with hepatic necrosisAlanine transaminase (ALT) is also called alanine ... or serum glutamic-pyruvic transaminase (SGPT). ALT is found in plasma and in various body tissues, but is most common in the ... aminotransferase (ALAT) and was formerly called serum glutamate-pyruvate transaminase (SGPT) ...
AminotransferasePyruvateGlutamatePlasma levels of alanineBilirubinSerum alanineLactate dehydrogenasePyridoxal phosphateProteinEnzymesLevelsFatty liverHepatitisBiomarkersElevationsELISABloodALT1MitochondrialSkeletal muscleRatioCatalyzesPathwayMetabolismAmino groupsWaistDiseaseLevelTransientLaboratoryUrea
Aminotransferase24
- The systematic name of this enzyme class is L-alanine:3-oxopropanoate aminotransferase . (wikipedia.org)
- Other names in common use include beta-alanine-pyruvate aminotransferase , and beta-alanine-alpha-alanine transaminase . (wikipedia.org)
- It is also called alanine aminotransferase (ALAT) and was formerly called serum glutamate-pyruvate transaminase or serum glutamic-pyruvic transaminase (SGPT) and was first characterized in the mid-1950s by Arthur Karmen and colleagues. (wikipedia.org)
- In 2000, the American Association for Clinical Chemistry determined that the appropriate terminology for AST and ALT are aspartate aminotransferase and alanine aminotransferase. (wikipedia.org)
- Other names in common use include alanine-oxomalonate aminotransferase, L-alanine-ketomalonate transaminase, and alanine-ketomalonate (mesoxalate) transaminase. (wikipedia.org)
- Alanine aminotransferase (ALT, alanine transaminase, SGPT) - serum. (medlineplus.gov)
- Alanine aminotransferase subfamily. (abcam.com)
- Called also alanine aminotransferase and glutamic-pyruvic transaminase . (thefreedictionary.com)
- Levels of the liver enzymes aspartate aminotransferase (AST) and alanine transaminase (ALT) did not differ between the naltrexone and placebo group at baseline or at 1 month of treatment, nor did the percentage of individuals with levels out of the normal range: 3. (thefreedictionary.com)
- Quantitative determination of alanine aminotransferase (ALT) activity in human serum. (viapath.co.uk)
- Alanine aminotransferase, alanine transaminase, (serum) glutamate pyruvate transaminase (SGPT). (viapath.co.uk)
- Diagnosis and monitoring of liver disease associated with hepatic necrosisAlanine transaminase (ALT) is also called alanine aminotransferase (ALAT) and was formerly called serum glutamate-pyruvate transaminase (SGPT) or serum glutamic-pyruvic transaminase (SGPT). (molq.in)
- Another "small Sanyang" middle aged patients, HBV DNA negative, but in January two liver function test alanine aminotransferase were more than 60 U/L. What is the reason? (scleritis.net)
- So for patients with mildly elevated alanine aminotransferase, 2 weeks after the review of normal, may be the cause of the accident, such as colds, strenuous exercise, menstrual period, drunk, etc. (scleritis.net)
- Alanine Transaminase (ALT) test is also known as Alanine aminotransferase test, Serum Glutamic-Pyruvate Transaminase, SGPT, and GPT. (1mg.com)
- Prior history was notable for HCV infection documented in March 2014 following mildly elevated blood alanine transaminase (ALT) and aspartate aminotransferase (AST) levels. (hindawi.com)
- Alanine aminotransferase (ALT) is an enzyme found mostly in the cells of the liver and kidney. (labtestsonline.org)
- In both strains of mice, plasma levels of alanine aminotransferase increased from week 1, when hepatic steatosis was also observed. (nih.gov)
- Cases were defined by a discrete onset of symptoms, alanine aminotransferase (ALT) levels greater than 2.5 times the upper limit of normal (xULN), negative findings for serologic markers for acute hepatitis A and B, and positive findings for antibody to HCV or HCV RNA. (mendeley.com)
- This test measures the level of alanine aminotransferase. (rochester.edu)
- The aim of this study was to evaluate the hepatoprotective effects of Bellamya javanica meat (BJM) in mice by quantifying alanine aminotransferase (ALT), aspartate transaminase (AST), and alkaline phosphatase (ALP) activity and observing liver histology. (innovareacademics.in)
- The aim of this study was to determine the prevalence of elevated serum alanine aminotransferase levels and the possible liver damages in this region. (ac.ir)
- The alanine aminotransferase (ALT) test is typically used to detect liver injury. (labcorp.com)
- 5 ) identify a syndrome characterized by the association of fatty liver and lobular hepatitis and chronically elevated alanine aminotransferase plasma levels in patients with negligible alcohol intake. (diabetesjournals.org)
Pyruvate20
- Thus, the two substrates of this enzyme are L-alanine and 3-oxopropanoate , whereas its two products are pyruvate and beta-alanine . (wikipedia.org)
- ALT catalyzes the transfer of an amino group from L-alanine to α-ketoglutarate, the products of this reversible transamination reaction being pyruvate and L-glutamate. (wikipedia.org)
- L-alanine + α-ketoglutarate ⇌ pyruvate + L-glutamate ALT (and all aminotransferases) require the coenzyme pyridoxal phosphate, which is converted into pyridoxamine in the first phase of the reaction, when an amino acid is converted into a keto acid. (wikipedia.org)
- In enzymology, an alanine-oxomalonate transaminase (EC 2.6.1.47) is an enzyme that catalyzes the chemical reaction L-alanine + oxomalonate ⇌ {\displaystyle \rightleftharpoons } pyruvate + aminomalonate Thus, the two substrates of this enzyme are L-alanine and oxomalonate, whereas its two products are pyruvate and aminomalonate. (wikipedia.org)
- Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate. (abcam.com)
- pyruvate from L-alanine: step 1/1. (abcam.com)
- an enzyme that catalyzes the reversible transfer of an amino group from alanine to α-ketoglutarate to form pyruvate and glutamate. (thefreedictionary.com)
- glutamic-pyruvate transaminase (alanine. (wikigenes.org)
- Formate dehydrogenase is integrated into the network to recycle NADH, which is needed for the reductive amination of pyruvate to alanine. (frontiersin.org)
- It is speculated that for efficient conversion of those ketones, the amine donor alanine and coproduct pyruvate as well as NADH and NAD + must be efficiently transferred between RTA and AlaDH and between AlaDH and FDH, respectively. (frontiersin.org)
- l‐alanine + 2‐oxoglutarate = pyruvate + l‐glutamate. (oup.com)
- Its function is to convert alanine (an amino acid found in proteins) to pyruvate (intermediate in cellular energy production). (1mg.com)
- L-alanine + glyoxylate = pyruvate + glycine. (uniprot.org)
- In muscle, pyruvate is converted to alanine, while in liver, alanine is converted to pyruvate. (prezi.com)
- Transamination of pyruvate by alanine transaminase, ALT (also referred to as serum glutamate-pyruvate transaminase, SGPT). (prezi.com)
- Pyruvate can be transaminated to alanine. (prezi.com)
- Within the liver, alanine is converted back to pyruvate by deamination. (prezi.com)
- The key feature of the cycle is that in 1 molecule, alanine, peripheral tissue exports pyruvate and ammonia to the liver, where the carbon skeleton is recycled and most nitrogen eliminated. (prezi.com)
- Please see the web pages for more details on AST (Serum glutamic-oxaloacetic transaminase- SGOT) and ALT (SGPT- Serum glutamate pyruvate transaminase). (yahoo.com)
- 2 The enzyme formerly known as GPT (glutamate pyruvate transaminase) has a new name: ALT (alanine aminotransfer. (bartleby.com)
Glutamate1
- one d -alanine transaminase effects the same reaction, but using d -alanine and d -glutamate. (thefreedictionary.com)
Plasma levels of alanine1
- We tested the association of rs72613567 with plasma levels of alanine transaminase (ALT) and clinical liver disease and mortality in 111,612 individuals from the Danish general population, including 497 with cirrhosis and 113 with hepatocellular carcinoma. (cdc.gov)
Bilirubin3
- 2 mmol/L Creatinine 91 [micro]mol/L Albumin 47 g/L Bilirubin 8 [micro]mol/L Alkaline phosphatase 93 IU/L Alanine transaminase 14 IU/L Corrected calcium 2. (thefreedictionary.com)
- Serum T3, T4, TSH were analyzed by electrochemiluminescence, total bilirubin by diazzonium ion (blanked) and ALT (Alanine transaminase) by IFCC without PLP method. (innovativepublication.com)
- Hepatotoxicity: Monitor liver laboratory tests every 2 weeks during the first 3 months of treatment, then once a month and as clinically indicated, with more frequent testing in patients who develop transaminase and bilirubin elevations. (nih.gov)
Serum alanine3
- Results: HCV etiology, Non-White race, and serum alanine transaminase (ALT) predicted elevated AFP in cirrhotics. (aacrjournals.org)
- Serum alanine transaminase levels in hospital personnel and effect before and after hepatitis B vaccination. (bvsalud.org)
- The elevation of serum alanine aminotranferase levels is associated most commonly with some forms of liver diseases. (ac.ir)
Lactate dehydrogenase1
- To assess the levels of serum lactate dehydrogenase (LDH), aspartate transaminase (AST) and alanine transaminase (ALT) among asphyxiated term neonates at birth (in cord blood), 0-4 hours and 18 to 24 hours after birth, to compare their levels in 3 grades of asphyxia, to correlate the values with the severity of asphyxia and to ascertain the best time interval for their estimation. (sljol.info)
Pyridoxal phosphate1
- This paper analyzes structural organization and pyridoxal phosphate (PLP) binding properties of Sc Alt1 and Sc Alt2 indicating functional diversification could have determined loss of Sc Alt2 alanine transaminase activity and thus its role in alanine metabolism. (frontiersin.org)
Protein1
- Alanine is the major amino acid present when muscle (protein) is degraded. (prezi.com)
Enzymes1
- For the multimeric enzymes R-ω-transaminase (RTA), alanine dehydrogenase (AlaDH), and formate dehydrogenase (FDH), peptide bond formation between the hetrosubunits has been achieved by the intein-mediated in vivo subunit splicing. (frontiersin.org)
Levels6
- The purpose of the study is to investigate the hepatoprotective effect of fermented turmeric powder (FTP) on liver function in subjects with elevated alanine transaminase (ALT) levels. (biomedcentral.com)
- The researchers found that pretreatment with baicalein significantly decreased aspartate transaminase (AST) and alanine transaminase (ALT) serum levels as well as apoptosis in the liver. (naturalnews.com)
- Alanine Transaminase test measures the levels of alanine transaminase in the blood. (1mg.com)
- Generally, these levels of alanine transaminase in the blood remain low in healthy individuals. (1mg.com)
- Alanine transaminase (ALT) levels in healthy hospital personnel were studied. (bvsalud.org)
- 3 No controlled clinical trials have compared approaches to the management of abnormal transaminase levels. (aafp.org)
Fatty liver3
- High Risk of Fatty Liver Disease Amplifies the Alanine Transaminase-Lowering Effect of a HSD17B13 Variant. (cdc.gov)
- It seemed that high proportions of people (16%) in this region had an elevated serum enzyme activity of alanine amino-tranferase and according to well-documented reports, it might probably be associated with non-alcoholic fatty liver disease. (ac.ir)
- This study was carried out to see the role of Alanine transaminase [ALT] as an indicator of Non Alcoholic Fatty liver disease [ NAFLD ] in patients having Type-2 Diabetes Mellitus . (bvsalud.org)
Hepatitis2
- But pay attention to a point, "small Sanyang" patients, the hepatitis B virus (HBV DNA) higher than 10 of the 5 party, no matter how much can transaminase, HBeAg negative chronic hepatitis B. Why, in general, the immune function under the action of "big 3 this world" to "small three", HBV DNA will soon turn. (scleritis.net)
- Potential causes of liver transaminase elevations include viral hepatitis, alcohol use, medication use, steatosis or steatohepatitis, and cirrhosis. (aafp.org)
Biomarkers1
- Serum ALT level, serum AST (aspartate transaminase) level, and their ratio (AST/ALT ratio) are commonly measured clinically as biomarkers for liver health. (wikipedia.org)
Elevations4
- Mild elevations in liver chemistry tests such as alanine transaminase and aspartate transaminase can reveal serious underlying conditions or have transient and benign etiologies. (aafp.org)
- Other common health conditions, such as diabetes, heart disease, and thyroid disease, can cause or augment liver transaminase elevations. (aafp.org)
- Given the frequency of this problem, physicians should develop an informed approach to the investigation of transaminase elevations. (aafp.org)
- In the asymptomatic patient with negative serum testing and mild transaminase elevations, a period of lifestyle modification can be tried. (aafp.org)
ELISA1
- This product has been assayed against 1.0 ug of Alanine Transaminase (ALT) [Pig Heart] in a standard sandwich ELISA using Peroxidase conjugated affinity purified anti-Sheep IgG [H&L] (Goat) and ABTS as a substrate for 30 minutes at RT. (abcam.com)
Blood4
- The alanine transaminase (ALT) blood test measures the level of the enzyme ALT in the blood. (medlineplus.gov)
- However, if there is any damage to the liver, alanine transaminase is released in the blood. (1mg.com)
- Hepatic transaminase tests such as alanine transaminase (ALT) and aspartate transaminase (AST) often are part of standard laboratory panels in asymptomatic outpatients, similar to screening tests for blood donors and for life insurance applicants. (aafp.org)
- The alanine then enters the blood stream and is transported to the liver. (prezi.com)
ALT11
- Diversification analysis of Sc Alt1/ Sc Alt2 indicated that while Sc Alt1 is an alanine transaminase, Sc Alt2 lost this activity, constituting an example in which one of the members of the gene pair lacks the apparent ancestral physiological role. (frontiersin.org)
Mitochondrial1
- Datta, K. (1986) Affinity purification and properties of rat liver mitochondrial L-alanine:4,5-dioxovalerate transaminase and its inhibition by hemin Archives of Biochemistry and Biophysics, 248 (2). (ias.ac.in)
Skeletal muscle1
- The glucose-alanine cycle occurs in skeletal muscle to eliminate nitrogen while replenishing (renewing) the energy supply for muscle. (prezi.com)
Ratio1
- The AST/ALT ratio (with AST being aspartate transaminase ) also has clinical significance. (wikipedia.org)
Catalyzes1
- It catalyzes the two parts of the alanine cycle. (wikipedia.org)
Pathway1
- This pathway is termed the glucose-alanine cycle. (prezi.com)
Metabolism1
- Only hemin among the intermediate compounds of heme metabolism tested was shown to be an inhibitor of purified alanine:4,5-dioxovalerate transaminase. (ias.ac.in)
Amino groups1
- Also known as Cahill cycle or alanine cycle.A series of reactions in which amino groups from the muscle are transported to the liver. (prezi.com)
Waist1
- EVOO supplementation was associated with a reduction in body weight, waist circumference, body mass index (BMI), alanine transaminase and FLI, as well as interleukin (IL)-6, IL-17A, tumor necrosis factor-α and IL-1B, while IL-10 increased. (unipa.it)
Disease1
- The term transaminase is outdated and no longer used in liver disease. (wikipedia.org)
Level2
- 1 This is consistent with the usual definition of an elevated transaminase level of the top 2.5 percent of the population range. (aafp.org)
- This test measures the level of aspartate transaminase. (rochester.edu)
Transient1
- It turned out that excessive strenuous exercise led to a transient fluctuation of transaminase. (scleritis.net)
Laboratory1
- In our study the laboratory parameter was observed alanine transaminase to be lower in dengue patients than the reference ranges. (thefreedictionary.com)
Urea1
- The amino group transported from the muscle to the liver in the form of alanine, is converted to urea in the urea cycle and excreted. (prezi.com)