OrganismsChemicals and DrugsPhenomena and ProcessesInformation Science
Alanine RacemaseRacemases and EpimerasesAlanineAmino Acid IsomerasesCycloserineAlanine DehydrogenaseAminoethylphosphonic AcidGeobacillus stearothermophilusBurkholderia malleiStereoisomerismPyridoxal PhosphateIsomerasesBacillus anthracisMolecular Sequence DataAmino Acid SequencePeriodic AcidEnterococcus faecalisEnterococcusEnterococcus faeciumAcetoin
Alanine Racemase
A pyridoxal-phosphate protein that reversibly catalyzes the conversion of L-alanine to D-alanine. EC 5.1.1.1.
Racemases and Epimerases
Enzymes that catalyze inversion of the configuration around an asymmetric carbon in a substrate having one (racemase) or more (epimerase) center(s) of asymmetry. (Dorland, 28th ed) EC 5.1.
Alanine
A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM.
Amino Acid Isomerases
Enzymes that catalyze either the racemization or epimerization of chiral centers within amino acids or derivatives. EC 5.1.1.
Cycloserine
Antibiotic substance produced by Streptomyces garyphalus.
Alanine Dehydrogenase
An NAD-dependent enzyme that catalyzes the reversible DEAMINATION of L-ALANINE to PYRUVATE and AMMONIA. The enzyme is needed for growth when ALANINE is the sole CARBON or NITROGEN source. It may also play a role in CELL WALL synthesis because L-ALANINE is an important constituent of the PEPTIDOGLYCAN layer.
Aminoethylphosphonic Acid
An organophosphorus compound isolated from human and animal tissues.
Geobacillus stearothermophilus
A species of GRAM-POSITIVE ENDOSPORE-FORMING BACTERIA in the family BACILLACEAE, found in soil, hot springs, Arctic waters, ocean sediments, and spoiled food products.
Burkholderia mallei
A species of gram-negative bacteria parasitic on HORSES and DONKEYS causing GLANDERS, which can be transmitted to humans.
Stereoisomerism
The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
Pyridoxal Phosphate
This is the active form of VITAMIN B 6 serving as a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. During transamination of amino acids, pyridoxal phosphate is transiently converted into pyridoxamine phosphate (PYRIDOXAMINE).
Isomerases
A class of enzymes that catalyze geometric or structural changes within a molecule to form a single product. The reactions do not involve a net change in the concentrations of compounds other than the substrate and the product.(from Dorland, 28th ed) EC 5.
Bacillus anthracis
A species of bacteria that causes ANTHRAX in humans and animals.
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Amino Acid Sequence
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
Periodic Acid
A strong oxidizing agent.
Enterococcus faecalis
A species of gram-positive, coccoid bacteria commonly isolated from clinical specimens and the human intestinal tract. Most strains are nonhemolytic.
Enterococcus
A genus of gram-positive, coccoid bacteria consisting of organisms causing variable hemolysis that are normal flora of the intestinal tract. Previously thought to be a member of the genus STREPTOCOCCUS, it is now recognized as a separate genus.
Enterococcus faecium
A species of gram-positive, coccoid bacteria whose organisms are normal flora of the intestinal tract. Unlike ENTEROCOCCUS FAECALIS, this species may produce an alpha-hemolytic reaction on blood agar and is unable to utilize pyruvic acid as an energy source.
Acetoin
A product of fermentation. It is a component of the butanediol cycle in microorganisms. In mammals it is oxidized to carbon dioxide.

Aromatic L-amino acid decarboxylase: conformational change in the flexible region around Arg334 is required during the transaldimination process. (1/84)

Aromatic L-amino acid decarboxylase (AADC) catalytic mechanism has been proposed to proceed through two consecutive intermediates (i.e., Michaelis complex and the external aldimine). Limited proteolysis of AADC that preferentially digested at the C-terminal side of Arg334 was slightly retarded in the presence of dihydroxyphenyl acetate that formed a stable Michaelis complex. On the contrary, AADC was scarcely digested in the presence of L-dopa methyl ester that formed a stable external aldimine. Similar protection by the substrate analogs was observed in the chemical modification experiment. From these results, we concluded that the region around Arg334 must be exposed and flexible in the unliganded state, and forming the Michaelis complex generated a subtle conformational change, then underwent marked conformational change during the subsequent transaldimination process prerequisite to forming the external aldimine. For further analyses, we constructed a mutant gene encoding in tandem the two peptides of AADC cleaved at the Asn327-Met328 bond inside the putative flexible region. The gene product, fragmentary AADC, was still active with L-dopa as substrate, but its k(cat) value was decreased 57-fold, and the Km value was increased 9-fold compared with those of the wild-type AADC. The absorption spectra of the fragmentary AADC in the presence of L-dopa methyl ester showed shift in the equilibrium of the transaldimination from the external aldimine to the Michaelis complex. Tryptic digestion of the fragmentary AADC removed seven amino acid residues, Met328-Arg334, and resulted in complete inactivation. Susceptibility of the fragmentary enzyme to trypsin was not changed by L-dopa methyl ester revealing the loss of appropriate conformational change in the flexible region induced by substrate binding. From these results we propose that the conformational change in the flexible region is required during the transaldimination process.  (+info)

Role of tyrosine 265 of alanine racemase from Bacillus stearothermophilus. (2/84)

Tyrosine 265 (Y265) of Bacillus stearothermophilus is believed to serve as a catalytic base specific to the L-enantiomer of a substrate amino acid by removing (or returning) an alpha-hydrogen from (or to) the isomer on the basis of the X-ray structure of the enzyme [Stamper, C.G., Morollo, A.A., and Ringe, D. (1998) Biochemistry 37, 10438-10443]. We found that the Y265-->Ala mutant (Y265A) enzyme is virtually inactive as a catalyst for alanine racemization. We examined the role of Y265 further with beta-chloroalanine as a substrate with the expectation that the Y265A mutant only catalyzes the alpha,beta-elimination of the D-enantiomer of beta-chloroalanine. However, L-beta-chloroalanine also served as a substrate; this enantiomer was rather better as a substrate than its antipode. Moreover, the mutant enzyme was as equally active as the wild-type enzyme in the elimination reaction. These findings indicate that Y265 is essential for alanine racemization but not for beta-chloroalanine elimination.  (+info)

Transcriptional control of peptidoglycan precursor synthesis during sporulation in Bacillus sphaericus. (3/84)

Synthesis of enzymes functional in the synthesis of nucleotide precursors of peptidoglycan ceases upon initiation of sporulation in Bacillus sphaericus. During sporulation, two periods of synthesis of these enzymes occur. The first starts at spore septum formation and is conincident with forespore engulfment; it involves the synthesis of those enzymes required for making the precursor of vegetative-type peptidoglycan, including L-lysyl ligase but no mesodiaminopimelyl ligase. The second period occurs shortly before the appearance of cortex. It involves the synthesis of diaminopimelyl ligase and the other enzymes needed for making the precursor of cortical peptidoglycan, but not lysyl ligase. Both events are a consequence of derepression at the level of transcription. Neither period of synthesis occurs in asporogenous mutants whose morphological block is at the point of spore septum formation.  (+info)

Tyrosine 265 of alanine racemase serves as a base abstracting alpha-hydrogen from L-alanine: the counterpart residue to lysine 39 specific to D-alanine. (4/84)

Alanine racemase of Bacillus stearothermophilus has been proposed to catalyze alanine racemization by means of two catalytic bases: lysine 39 (K39) abstracting specifically the alpha-hydrogen of D-alanine and tyrosine 265 (Y265) playing the corresponding role for the antipode L-alanine. The role of K39 as indicated has already been verified [Watanabe, A., Kurokawa, Y., Yoshimura, T., Kurihara, T., Soda, K., and Esaki, N. (1999) J. Biol. Chem. 274, 4189-4194]. We here present evidence for the functioning of Y265 as the base catalyst specific to L-alanine. The Y265-->Ala mutant enzyme (Y265A), like Y265S and Y265F, was a poor catalyst for alanine racemization. However, Y265A and Y265S catalyzed transamination with D-alanine much more rapidly than the wild-type enzyme, and the bound coenzyme, pyridoxal 5'-phosphate (PLP), was converted to pyridoxamine 5'-phosphate (PMP). The rate of transamination catalyzed by Y265F was about 9% of that by the wild-type enzyme. However, Y265A, Y265S, and Y265F were similar in that L-alanine was inert as a substrate in transamination. The apo-form of the wild-type enzyme catalyzes the abstraction of tritium non-specifically from both (4'S)- and (4'R)-[4'-(3)H]PMP in the presence of pyruvate. In contrast, apo-Y265A abstracts tritium virtually from only the R-isomer. This indicates that the side-chain of Y265 abstracts the alpha-hydrogen of L-alanine and transfers it supra-facially to the pro-S position at C-4' of PMP. Y265 is the counterpart residue to K39 that transfers the alpha-hydrogen of D-alanine to the pro-R position of PMP.  (+info)

A eukaryotic alanine racemase gene involved in cyclic peptide biosynthesis. (5/84)

The cyclic tetrapeptide HC-toxin is an essential virulence determinant for the plant pathogenic fungus Cochliobolus carbonum and an inhibitor of histone deacetylase. The major form of HC-toxin contains the D-isomers of Ala and Pro. The non-ribosomal peptide synthetase that synthesizes HC-toxin has only one epimerizing domain for conversion of L-Pro to D-Pro; the source of D-Ala has remained unknown. Here we present the cloning and characterization of a new gene involved in HC-toxin biosynthesis, TOXG. TOXG is present only in HC-toxin-producing (Tox2(+)) isolates of C. carbonum. TOXG is able to support D-Ala-independent growth of a strain of Escherichia coli defective in D-Ala synthesis. A C. carbonum strain with both of its copies of TOXG mutated grows normally in culture, and although it no longer makes the three forms of HC-toxin that contain D-Ala, it still makes a minor form of HC-toxin that contains Gly in place of D-Ala. The addition of D-Ala to the culture medium restores production of the D-Ala-containing forms of HC-toxin by the toxG mutant. The toxG mutant has only partially reduced virulence. It is concluded that TOXG encodes an alanine racemase whose function is to synthesize D-Ala for incorporation into HC-toxin.  (+info)

The manifold of vitamin B6 dependent enzymes. (6/84)

Pyridoxal-5'-phosphate (vitamin B6) binding enzymes form a large superfamily that contains at least five different folds. The availability of an increasing number of known three-dimensional structures for members of this superfamily has allowed a detailed structural classification. Most progress has been made with the fold type I or aspartate aminotransferase family.  (+info)

Serine and alanine racemase activities of VanT: a protein necessary for vancomycin resistance in Enterococcus gallinarum BM4174. (7/84)

Vancomycin resistance in Enterococcus gallinarum results from the production of UDP-MurNAc-pentapeptide[D-Ser]. VanT, a membrane-bound serine racemase, is one of three proteins essential for this resistance. To investigate the selectivity of racemization of L-Ser or L-Ala by VanT, a strain of Escherichia coli TKL-10 that requires D-Ala for growth at 42 degrees C was used as host for transformation experiments using plasmids containing the full-length vanT from Ent. gallinarum or the alanine racemase gene (alr) of Bacillus stearothermophilus: both plasmids were able to complement E. coli TKL-10 at 42 degrees C. No alanine or serine racemase activities were detected in the host strain E. coli TKL-10 grown at 30, 34 or 37 degrees C. Serine and alanine racemase activities were found almost exclusively (96%) in the membrane fraction of E. coli TKL-10/pCA4(vanT): the alanine racemase activity of VanT was 14% of the serine racemase activity in both E. coli TKL-10/pCA4(vanT) and E. coli XL-1 Blue/pCA4(vanT). Alanine racemase activity was present mainly (95%) in the cytoplasmic fraction of E. coli TKL-10/pJW40(alr), with a trace (1.6%) of serine racemase activity. Additionally, DNA encoding the soluble domain of VanT was cloned and expressed in E. coli M15 as a His-tagged polypeptide and purified: this polypeptide also exhibited both serine and alanine racemase activities; the latter was approximately 18% of the serine racemase activity, similar to that of the full-length, membrane-bound enzyme. N-terminal sequencing of the purified His-tagged polypeptide revealed a single amino acid sequence, indicating that the formation of heterodimers between subunits of His-tagged C-VanT and endogenous alanine racemases from E. coli was unlikely. The authors conclude that the membrane-bound serine racemase VanT also has alanine racemase activity but is able to racemize serine more efficiently than alanine, and that the cytoplasmic domain is responsible for the racemase activity.  (+info)

Functional characterization of alanine racemase from Schizosaccharomyces pombe: a eucaryotic counterpart to bacterial alanine racemase. (8/84)

Schizosaccharomyces pombe has an open reading frame, which we named alr1(+), encoding a putative protein similar to bacterial alanine racemase. We cloned the alr1(+) gene in Escherichia coli and purified the gene product (Alr1p), with an M(r) of 41,590, to homogeneity. Alr1p contains pyridoxal 5'-phosphate as a coenzyme and catalyzes the racemization of alanine with apparent K(m) and V(max) values as follows: for L-alanine, 5.0 mM and 670 micromol/min/mg, respectively, and for D-alanine, 2.4 mM and 350 micromol/min/mg, respectively. The enzyme is almost specific to alanine, but L-serine and L-2-aminobutyrate are racemized slowly at rates 3.7 and 0.37% of that of L-alanine, respectively. S. pombe uses D-alanine as a sole nitrogen source, but deletion of the alr1(+) gene resulted in retarded growth on the same medium. This indicates that S. pombe has catabolic pathways for both enantiomers of alanine and that the pathway for L-alanine coupled with racemization plays a major role in the catabolism of D-alanine. Saccharomyces cerevisiae differs markedly from S. pombe: S. cerevisiae uses L-alanine but not D-alanine as a sole nitrogen source. Moreover, D-alanine is toxic to S. cerevisiae. However, heterologous expression of the alr1(+) gene enabled S. cerevisiae to grow efficiently on D-alanine as a sole nitrogen source. The recombinant yeast was relieved from the toxicity of D-alanine.  (+info)

New Classes of Alanine Racemase Inhibitors Identified by High-Throughput Screening Show Antimicrobial Activity against...
PubMed Central Canada (PMC Canada) provides free access to a stable and permanent online digital archive of full-text, peer-reviewed health and life sciences research publications. It builds on PubMed Central (PMC), the U.S. National Institutes of Health (NIH) free digital archive of biomedical and life sciences journal literature and is a member of the broader PMC International (PMCI) network of e-repositories.
http://pubmedcentralcanada.ca/pmcc/articles/PMC3102704/?lang=en-ca
Structural insights into the alanine racemase from Enterococcus faecalis<...
TY - JOUR. T1 - Structural insights into the alanine racemase from Enterococcus faecalis. AU - Priyadarshi, Amit. AU - Lee, Eun Hye. AU - Sung, Min Woo. AU - Nam, Ki Hyun. AU - Lee, Won Ho. AU - Kim, Eunice EunKyeong. AU - Hwang, Kwang Yeon. PY - 2009/7/1. Y1 - 2009/7/1. N2 - Alanine racemase (AlaR) is a bacterial enzyme that belongs to the fold-type III group of pyridoxal 5′-phosphate (PLP)-dependent enzymes. AlaR catalyzes the interconversion between l- and d-alanine, which is important for peptidoglycan biosynthesis. This enzyme is common in prokaryotes, but absent in eukaryotes, which makes it an attractive target for the design of new antibacterial drugs. Here, we report the crystal structures of both the apoenzyme and the d-cycloserine (DCS) complex of AlaR from the pathogenic bacterium Enterococcus faecalis v583, at a resolution of 2.5 Å. DCS is a suicide inhibitor of AlaR and, as such, serves as an antimicrobial agent and has been used to treat tuberculosis and urinary tract ...
https://koreauniv.pure.elsevier.com/en/publications/structural-insights-into-the-alanine-racemase-from-enterococcus-f
Alanine racemase elisa and antibodyAlanine racemase elisa and antibody
Shop Alanine racemase ELISA Kit, Recombinant Protein and Alanine racemase Antibody at MyBioSource. Custom ELISA Kit, Recombinant Protein and Antibody are available.
https://www.mybiosource.com/protein_family.php?root=alanine-racemase
Silica-immobilized His(6)-tagged enzyme : Alanine racemase in hydrophobic solventSilica-immobilized His(6)-tagged enzyme : Alanine racemase in hydrophobic solvent
A new immobilization method for enzymes is presented to facilitate synthetic applications in aqueous as well as organic media. The enzyme Alanine racemase (AlaR) from Geobacillus stearothermophilus was cloned, overexpressed and then immobilized on a silica-coated thin-layer chromatography plate to create an enzyme surface. The enzyme, fused to a His(6)-tag at its N-terminal, was tethered to the chemically modified silica-coated TLC plate through cobalt ions. The immobilized enzyme showed unaltered kinetic parameters in small-scale stirred reactions and retained its activity after rinsing, drying, freezing or immersion in n-hexane. This practical method is a first step towards a general immobilization method for synthesis applications with any enzyme suitable for His(6)-tagging.. ...
http://kth.diva-portal.org/smash/record.jsf?pid=diva2:335319
Active site of A. baumannii alanine racemase. (a) 2Fo | Open-iActive site of A. baumannii alanine racemase. (a) 2Fo | Open-i
Active site of A. baumannii alanine racemase. (a) 2Fo− Fc electron-density map of the active site contoured at 1.0σ with isomesh map shown (1.6 Å carve).
https://openi.nlm.nih.gov/detailedresult.php?img=PMC4157418_f-70-01199-fig5&req=4
Alanine racemase C-terminal domain-like superfamilyAlanine racemase C-terminal domain-like superfamily
The SCOP classification for the Alanine racemase C-terminal domain-like superfamily including the families contained in it. Additional information provided includes InterPro annotation (if available), Functional annotation, and SUPERFAMILY links to genome assignments, alignments, domain combinations, taxonomic visualisation and hidden Markov model information.
http://supfam.mrc-lmb.cam.ac.uk/SUPERFAMILY/cgi-bin/scop.cgi?sunid=50621
EC 5.1.1.1EC 5.1.1.1
Accepted name: alanine racemase. Reaction: L-alanine = D-alanine. Other name(s): L-alanine racemase. Systematic name: alanine racemase. Comments: A pyridoxal-phosphate protein.. Links to other databases: BRENDA, EXPASY, GTD, KEGG, Metacyc, PDB, CAS registry number: 9024-06-0. References:. 1. Marr, A.G. and Wilson, P.W. The alanine racemase of Brucella abortus. Arch. Biochem. Biophys. 49 (1954) 424-433.. 2. Wood, W.A. Amino acid racemases. Methods Enzymol. 2 (1955) 212-217.. 3. Wood, W.A. and Gunsalus, I.C. D-Alanine formation: a racemase in Streptococcus faecalis. J. Biol. Chem. 190 (1951) 403-416.. ...
http://www.sbcs.qmul.ac.uk/iubmb/enzyme/EC5/1/1/1.html
30 Tips for Styling Your Entryway Table - Mamici Magice
For homes that have a narrow entryway, try to keep things light and airy. We love the pale table and decorations that are used in this entryway from Jessica Nelson Design. Even with a reasonable size table, you wont feel like the space is too cluttered. Pale wood and white work well together to create a calming first welcome to any home and will look good in both modern and traditional buildings. The basket to the side of the table is a great addition, and you can hide clutter in there instead of placing it on the table.. We hope youve enjoyed this look into styling your entryway table and will take inspiration from some of these projects the next time you restyle this area. Remember, the entryway can be adjusted throughout the year to reflect the seasons. By adding a fun, welcoming table to your home at Halloween or Christmas, youll set the tone for the rest of the house when you have friends and family to visit. Redecorating this space is easy to achieve with very little time or money. Have ...
https://mamicimagice.com/2021/03/26/30-tips-for-styling-your-entryway-table/
Global D-Alanine Racemase Market Research Report 2018 Share, Size, Analysis and Forecast 2023 - Market Research Reports and...
D-Alanine Racemase Report by Material, Application, and Geography - Global Forecast to 2022 is a professional and in-depth research report on the worlds major regional market conditions, focusing on the main regions (North America, Europe and Asia-Pacific) and the main countries (United States, Ger
https://9dimenresearchstore.com/report/global-dalanine-racemase-market-2861
Its A Grandville Life : Narrow Front Entryway Ideas, Small And Narrow Entryway Ideas - LukeIts A Grandville Life : Narrow Front Entryway Ideas, Small And Narrow Entryway Ideas - Luke
Small and narrow entryway ideas: its a grandville life : narrow front entryway ideas, making the most out of my narrow hallway entrance one, 37 best entry table ideas (decorations and designs) for 2017
https://www.lukeseatinghouse.com/1202/13/
Silicone Entryway Storage, Coat Racks & Silicone Umbrella Stands | The Container StoreSilicone Entryway Storage, Coat Racks & Silicone Umbrella Stands | The Container Store
Shop Silicone Entryway Storage & Coat Racks at The Container Store. Give a warm welcome with a tidy entry! The Container Stores entryway storage options offer convenient coat racks and umbrella stands - Shop now! Shop Entryway Storage & Coat Racks today.
https://www.containerstore.com/s/entryway/Silicone/White/1lc
WikiGenes - dadX - alanine racemaseWikiGenes - dadX - alanine racemase
The worlds first wiki where authorship really matters. Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts.
https://www.wikigenes.org/e/gene/e/3994254.html
Sequence Similarity Search - BLAST
ppu:PP_5269 K01775 alanine racemase [EC:5.1.1.1] , (RefSeq) dadX; alanine racemase (A) MRPARALIDLQALRHNYRLARELTGAKALAVIKADAYGHGAVRCALALEAEADGFAVACI EEALELRAAGIKAPVLLLEGFFEASELALIAEHDLWCVVHSLWQLEAIEKTPLHKPLNVW LKLDSGMHRVGLHPKDYHDAYQRLLASGKVSRIVLMTHFARADELDADATSQQIAVFEAA RQGLAAECSLRNSPGVLGWPQAPSDWVRPGLMLYGATPFEVAQAEAARLQPVMTLQSRVI SVRELPAGEPVGYGAKFVSPRPTRVGVVAMGYADGYPRQAPNGTPVLVAGKRTQLIGRVS MDMLSIDLTDVPQATVGSPVEFWGKQVLASEVAAHAGTIPYQIFCNLKRVPRDYIGE ...
http://www.genome.jp/tools-bin/search_sequence?prog=blast&seqid=ppu:PP_5269+aa
Sequence Similarity Search - BLAST
vpa:VP2734 K01775 alanine racemase [EC:5.1.1.1] , (RefSeq) alr; alanine racemase (A) MKAAKACIDLSALQHNLQRVKAQAPESKVMAVVKANGYGHGLRHVAKHANHADAFGVARI EEALQLRACGVVKPILLLEGFYSPGDLPVLVTNNIQTVVHCEEQLIALEQADLETPVVVW LKIDSGMHRLGVRPEQYDEFISRLKTCPNVAKPLRYMSHFGCADELDSSITPQQIELFMS LTSGCQGERSLAASAGLLAWPQSQLEWVRPGIIMYGVSPFSDKTAQDLGYQPVMTLKSHL IAVREVKQGESVGYGGIWTSERDTKVGVIAVGYGDGYPRSAPNGTPVWVNGRTVPIAGRV SMDMLTVDLGPDATDKVSDEAILWGKELPVEEVANHIGTIAYELVTKLTPRVEMEYTK ...
http://www.genome.jp/tools-bin/search_sequence?prog=blast&seqid=vpa:VP2734+aa
alanine racemase [Frankia sp. CcI3] - Protein - NCBIalanine racemase [Frankia sp. CcI3] - Protein - NCBI
This record was replaced or removed. The sequence YP_479735 is 100% identical to WP_011435075.1 over its full length. Be aware that a NCBI nonredundant RefSeq protein (WP_) can be annotated on large numbers of bacterial genomes that encode that identical protein.. Old YP_479735.1 New WP_011435075.1 Identical proteins Re-annotation project. ...
https://www.ncbi.nlm.nih.gov/protein/86739335
garage door springs menards
You may likewise have an old, one piece entryway that swings outward as it goes up and overhead. This specific plan will have springs mounted on the sides of the entryway opening - at about your midriff stature, gotten to a switch section framework that broadens the springs toward the roof at the entryway shutting. Its anything but an old and very risky framework, not made any longer. On the off chance that you have such a framework in the carport, Id energetically suggest supplanting it.. Carport entryway twist springs - there are either single or twofold spring plans. The spring will typically break while under the greatest pressure which is the point at which the overhead carport entryway shuts/goes down, or it is as of now totally shut (USUALLY). In case youre shutting it physically and it occurs during this activity, dont attempt to keep it from pounding down, let it go … indeed, except if your foot is the place where the entryway will hammer!. At the point when one of the two carport ...
https://oemeco.com/tag/garage-door-springs-menards/
ZipWall Heavy Duty Zipper - How to Create an Entryway in a Dust ...ZipWall Heavy Duty Zipper - How to Create an Entryway in a Dust ...
Watch ZipWall Heavy Duty Zipper - How to Create an Entryway in a Dust Barrier - Video | Environmental XPRT. How to quickly create an entryway in a plastic ...
https://www.environmental-expert.com/videos/zipwall-heavy-duty-zipper-how-to-create-an-entryway-in-a-dust-barrier-video-791046
PDB 2rjh structure summary ‹ Protein Data Bank in Europe (PDBe) ‹ EMBL-EBIPDB 2rjh structure summary ‹ Protein Data Bank in Europe (PDBe) ‹ EMBL-EBI
2rjh: Residues Asp164 and Glu165 at the substrate entryway function potently in substrate orientation of alanine racemase from E. coli: Enzymatic characterization with crystal structure analysis.
https://www.ebi.ac.uk/pdbe/entry/pdb/2rjh
AID 726209 - Inhibition of human recombinant DAO expressed in G418-resistant HEK293/NEO cells assessed as effect on D-alanine...AID 726209 - Inhibition of human recombinant DAO expressed in G418-resistant HEK293/NEO cells assessed as effect on D-alanine...
BioAssay record AID 726209 submitted by ChEMBL: Inhibition of human recombinant DAO expressed in G418-resistant HEK293/NEO cells assessed as effect on D-alanine level at 17 uM incubated for 30 mins prior to D-alanine addition measured after 24 hrs by HPLC analysis relative to vehicle-treated control.
https://pubchem.ncbi.nlm.nih.gov/bioassay/726209
Essentiality of Mycobacterium tuberculosis D-alanine racemase - Ofelia ChaconEssentiality of Mycobacterium tuberculosis D-alanine racemase - Ofelia Chacon
Mycobacterium tuberculosis (Mtb), the main etiologic agent of human tuberculosis (TB), remains a leading cause of worldwide morbidity and mortality. The percent...
https://grantome.com/grant/NIH/R21-AI087561-02
Plumbing Nightmares and Entryway Dreams | Rehab Addict | DIY
After transforming the exterior of the Minnehaha House, Nicole Curtis turns her attention to the interior where massive plumbing and electrical problems lurk behind the walls. Construction cannot start until the 100-year-old wiring and piping are up to code, and that means the little Sheetrock that is up must come down. At the same time, anxious to get started on cosmetic work, Nicole restores antique exterior sconces, and works with restoration experts to repair the glass window for the grand front door. When the lights finally go on and the water flows, the walls go up throughout the house and Nicole completes her entryway restoration.
http://www.diynetwork.com/shows/rehab-addict/episodes/100/plumbing-nightmare-to-powder-room-dreams
Replacing exterior exposed non weight bearing beams in entryway | This Old HouseReplacing exterior exposed non weight bearing beams in entryway | This Old House
Help -- Our entryway here in California has beams extending from the roof line that create a nice little bit of shade, an arbor for large fushia and climber roses as well as an nice entry statement. These are non weight bearing 5x6 x 24 and extend 18 under the roof line. The Stucco wall holding the beam ends need a lot of help as well as you can see from the photos-- well, cant seem to get the photos small enough - can anyone help with that?
https://www.thisoldhouse.com/discussions/topic/replacing-exterior-exposed-non-weight-bearing-beams-entryway
Entryway and Hallway | Storage | JYSK.CAEntryway and Hallway | Storage | JYSK.CA
At JYSK Canada, we offer a wide range of furniture for your hallway such as benches, coat stands, shoe racks and shoe cupboards, hallway shelves, and coat hooks and hangers. Browse our selection of entryway and hallway furniture on JYSK.CA today!
https://www.jysk.ca/storage/entryway-hallway.html?colour=234%2C239
Entryway Mats - Free ShippingEntryway Mats - Free Shipping
Keep your building clean and safe using a three stage entry mat system: Outdoor Scraper Mats to stop dirt before it gets inside, Entryway Wiper/Scraper Mats to clean up remaining dirt and trap water, and Interior Wiper Carpet Mats to protect your floors.
http://www.gotopac.com/products/floor-mats/entryway-mats.html?manufacturer=1231&p_length=138
Entryway Mats - Free ShippingEntryway Mats - Free Shipping
Keep your building clean and safe using a three stage entry mat system: Outdoor Scraper Mats to stop dirt before it gets inside, Entryway Wiper/Scraper Mats to clean up remaining dirt and trap water, and Interior Wiper Carpet Mats to protect your floors.
http://www.gotopac.com/products/floor-mats/entryway-mats.html?p_length=1725
Come On In: Welcoming and Stylish Entryway Ideas
Your entryway is the first part of the home any visitor will encounter.Take a look at this compilation ideas on how to create a flawless first impression.
https://wuwizz.com/entryway-ideas/
Best 25+ Cote de texas ideas on Pinterest | Arched interior doors, Stone sink and Grand entrywayBest 25+ Cote de texas ideas on Pinterest | Arched interior doors, Stone sink and Grand entryway
Find and save ideas about Cote de texas on Pinterest. | See more ideas about Arched interior doors, Stone sink and Grand entryway.
https://gr.pinterest.com/explore/cote-de-texas/
A bit of Abbey Lee Kershaw listing. There isnt Elisabeth Harnois there. Signora Colorni opened the entryway, a little lady...
A bit of Abbey Lee Kershaw listing. There isnt Elisabeth Harnois there. Signora Colorni opened the entryway, a little lady with a dark top and blue displays ...
http://shaneru.net/9149584/888112346.html
Multi-Color, Entryway, Chandeliers | Lamps PlusMulti-Color, Entryway, Chandeliers | Lamps Plus
Browse Entryway Multi-Color chandeliers - 62 available at Lamps Plus! 120% low price protection guarantee - Possini Euro Fabrizio 22&Quot; Wide Contemporary Glass Pendant, Avalon Br...
http://www.lampsplus.com/products/chandeliers/[email protected]/usage_entryway/
Gray, Seedling By Thomas Paul, Entryway, Chandeliers | Lamps PlusGray, Seedling By Thomas Paul, Entryway, Chandeliers | Lamps Plus
Entryway Gray Seedling By Thomas Paul chandeliers at Lamps Plus! 120% low price protection guarantee - Seedling By Thomaspaul Damask 24&Quot; Wide Pendant Chandelier, Seedling By Th...
http://www.lampsplus.com/products/chandeliers/color_gray/usage_entryway/manufacturer_seedling-by-thomas-paul/
DiVA - Search resultDiVA - Search result
Three C X bond formation mechanisms observed in the oxidation of (HBpz(3))ReO(R)(OTf) [HBpz(3) = hydrotris(1-pyrazolypborate; R = Me, Et, and iPr; OTf = OSO(2)CF(3)] by dimethyl sulfoxide (DMSO) were investigated using quantum mechanics (M06//B3LYP DFT) combined with solvation (using the PBF Poisson Boltzmann polarizable continuum solvent model). For R = Et we find the alkyl group is activated through alpha-hydrogen abstraction by external base OTf(-) with a free energy barrier of only 12.0 kcal/mol, leading to formation of acetaldehyde. Alternatively, ethyl migration across the M=O bond (leading to the formation of acetaldehyde and ethanol) poses a free energy barrier of 22.1 kcal/mol, and the previously proposed alpha-hydrogen transfer to oxo (a 2+2 forbidden reaction) poses a barrier of 44.9 kcal/mol. The rate-determining step to formation of the final product acetaldehyde is an oxygen atom transfer from DMSO to the ethylidene, with a free energy barrier of 15.3 kcal/mol. When R = iPr, the ...
http://kth.diva-portal.org/smash/resultList.jsf?af=%5B%5D&aq=%5B%5B%7B%22personId%22%3A%22authority-person%3A31658+OR+0000-0002-1553-4027%22%7D%5D%5D&aqe=%5B%5D&aq2=%5B%5B%5D%5D&language=en&query=
Ausgewählte Publikationen des Jahres 2014 • Chemie • Fachbereich Biologie, Chemie, PharmazieAusgewählte Publikationen des Jahres 2014 • Chemie • Fachbereich Biologie, Chemie, Pharmazie
NMR Studies of Protonation and Hydrogen Bond States of Internal Aldimines of Pyridoxal 5-Phosphate Acid-Base in Alanine Racemase, Aspartate Aminotransferase and Poly-L-lysine. Monique Chan-Huot, Alexandra Dos, Reinhard Zander, Shasad Sharif, Peter M. Tolstoy, Shara Compton, Emily Fogle, Michael D. Toney, Ilya Shenderovich, Gleb S. Denisov, and Hans-Heinrich Limbach, J. Am. Chem. Soc. 2013, 135(48), 18160-18175. ...
https://www.bcp.fu-berlin.de/chemie/chemie/_PaperHighlightsArchive/2014.html
SWISS-MODEL Template Library | 6q70.1
SWISS-MODEL Template Library (SMTL) entry for 6q70.1. Crystal structure of the alanine racemase Bsu17640 from Bacillus subtilis in the presence of HEPES
https://swissmodel.expasy.org/templates/6q70
The Summoning Pits/Walkthrough - Destinypedia, the Destiny wikiThe Summoning Pits/Walkthrough - Destinypedia, the Destiny wiki
Boss: Phogoth, the Untamed The final room contains Phogoth, who is initially chained up. The room also has multiple balconies with enemies on them, including Knights and Acolytes armed with Boomers. Players should take advantage of the situation and take out the Boomer-equipped enemies before engaging Phogoth, as he will not attack until he breaks free which will only happen if he is damaged. Players can hang back in the initial doorway, though a Shrieker will periodically spawn in that room, and Thralls and Knights will try to swarm them. The narrow doorway also makes it difficult to hit Phogoth without being exposed to its Eye Beam attack. The sides offer more protection than the entryway, though in a pinch Guardians can hide behind the narrow columns on the entryway balcony. Inside the room itself, Phogoth is partially penned in by large walls, three on either side. So long as players keep the walls between Phogoth and themselves, they are relatively safe from its Eye Beam attack. Stronger ...
https://www.destinypedia.com/The_Summoning_Pits/Walkthrough
Targeting Dual Points of Entry | A&U Magazine
Drug discovery and early to mid-stage drug development for HIV primarily takes place at academic institutions and small biotechnology companies. At the Frontiers in Developing Antiretroviral Therapy Conference (HIV DART 2014), which took place from December 9-12 in Miami, Florida, there were numerous presentations on promising new treatments for HIV being researched by academic institutions. One project that particularly stood out involved the development of early stage, dual-tropic HIV entry inhibitors that also inhibit HIV reverse transcriptase.. HIV entry into immune cells involves an initial interaction between the viral surface receptor, gp120, and the human cell surface receptor, CD4. This is followed by a subsequent interaction with one of two human cell surface co-receptors: CCR5 or CXCR4. CCR5 is the entryway for M-tropic viruses and CXCR4 is the entryway for T-tropic viruses. Tropism simply refers to the type of cell that HIV infects, and thus characterizes different HIV strains. ...
http://aumag.org/2015/02/18/targeting-dual-points-of-entry/
Ten June: Entryway Design: Before & After PicsTen June: Entryway Design: Before & After Pics
That board + batten treatment is divine. As part of my e-designs, I provide clients with an extensive source list and (if youre up for it!) a full DIY tutorial for any DIY suggestions I make. I certainly gave her a full tutorial for the board + batten treatment; hopefully my suggestions really helped her as she made over the space ...
http://www.tenjuneblog.com/2012/06/entryway-design-before-after-pics.html?showComment=1338898171848
News - Tagged ModernFarmhouse - Catanexus
Sometimes, its truly amazing how affordable and simple it can be! Having a modern farmhouse entryway is like entering a home, and it greets you with a nice hug. If you are eager to add this space in your home, we have a great collection today, which is about modern farmhouse entryway ideas with bench that are affordable and doable. All of these great spaces, regardless of how small or big, embrace you as you come home and provide you with that homey feeling. We are hoping you get completely motivated to produce a welcoming space of your own. It.... ...
https://catanexus.com/blogs/news/tagged/modernfarmhouse
Small Entryway Makeover: Add Board and Batten Wainscotting & Bench to a Small EntranceSmall Entryway Makeover: Add Board and Batten Wainscotting & Bench to a Small Entrance
This small entry became much more functional with the addition of a bench and board and batten along one wall. Now theres a space to hang scarves, coats, as well as a place for pulling on boots and cold weather gear.
https://betweennapsontheporch.net/small-entryw-makeover-add-storage-and-function-with-board-batten-wainscoting/?replytocom=121656
Small Entryway Makeover: Add Board and Batten Wainscotting & Bench to a Small EntranceSmall Entryway Makeover: Add Board and Batten Wainscotting & Bench to a Small Entrance
This small entry became much more functional with the addition of a bench and board and batten along one wall. Now theres a space to hang scarves, coats, as well as a place for pulling on boots and cold weather gear.
https://betweennapsontheporch.net/small-entryw-makeover-add-storage-and-function-with-board-batten-wainscoting/?replytocom=121188
Slim Bookcases in Natural Steel - Modern Storage and Entryway Furniture - Room & BoardSlim Bookcases in Natural Steel - Modern Storage and Entryway Furniture - Room & Board
|p|The recycled natural steel of our Slim bookcase gives weight to a handcrafted design that features subtle weld marks unique to each piece.|/p|
https://www.roomandboard.com/catalog/storage-and-entryway/room-dividers/slim-bookcases-in-natural-steel
About Taunton Garage Door with its speciality - Libertarian Party Of HawaiiAbout Taunton Garage Door with its speciality - Libertarian Party Of Hawaii
Insulation. In the circumstances, including private appended carports where the protecting worth and the vitality proficiency of a carport entryway is critical to forestall overheating and freezing issues, just as for solace and vitality reserve funds.. A few producers publicize exceptionally high protecting qualities for a portion of their carport entryways (R-15 to R-17); however, it might be valid for just for some focal segments. The genuine R-values - for the full entry - are frequently 1/2 or 1/3 of the promoted esteem.. Twist spring lift mechanism. A twist spring balance framework comprises of a couple of firmly wrapped up springs on a steel shaft with link drums at the two finishes. The whole contraption mounts on the header divider over the carport entryway and has three backings: a middle bearing plate with a steel or nylon bearing and two end bearing plates at the two finishes. The springs themselves comprise of the steel wire with a fixed cone toward one side and a winding cone at ...
http://www.libertarianpartyofhawaii.org/about-taunton-garage-door-with-its-speciality/
Regulation of the dauBAR operon and characterization of d-amino acid dehydrogenase DauA in arginine and lysine catabolism of...Regulation of the dauBAR operon and characterization of d-amino acid dehydrogenase DauA in arginine and lysine catabolism of...
A unique d-to-l racemization of arginine by coupled arginine dehydrogenases DauA and DauB encoded by the dauBAR operon has been recently reported as a prerequisite for d-arginine utilization as the sole source of carbon and nitrogen through l-arginine catabolic pathways in P. aeruginosa. In this study, enzymic properties of the catabolic FAD-dependent d-amino acid dehydrogenase DauA and the physiological functions of the dauBAR operon were further characterized with other d-amino acids. These results establish DauA as a d-amino acid dehydrogenase of broad substrate specificity, with d-Arg and d-Lys as the two most effective substrates, based on the kinetic parameters. In addition, expression of dauBAR is specifically induced by exogenous d-Arg and d-Lys, and mutations in the dauBAR operon affect utilization of these two amino acids alone. The function of DauR as a repressor in the control of the dauBAR operon was demonstrated by dauB promoter activity measurements in vivo and mobility shift assays with
https://www.microbiologyresearch.org/content/journal/micro/10.1099/mic.0.033282-0
Permalien vers Combined approaches for drug design points the way to novel proline racemase inhibitor candidates to fight...Permalien vers Combined approaches for drug design points the way to novel proline racemase inhibitor candidates to fight...
Lien vers Pubmed [PMID] - 23613764. PLoS ONE 2013;8(4):e60955. Chagas disease is caused by Trypanosoma cruzi, a protozoan transmitted to humans by blood-feeding insects, blood transfusion or congenitally. Previous research led us to discover a parasite proline racemase (TcPRAC) and to establish its validity as a target for the design of new chemotherapies against the disease, including its chronic form. A known inhibitor of proline racemases, 2-pyrrolecarboxylic acid (PYC), is water-insoluble. We synthesized soluble pyrazole derivatives, but they proved weak or inactive TcPRAC inhibitors. TcPRAC catalytic site is too small and constrained when bound to PYC to allow efficient search for new inhibitors by virtual screening. Forty-nine intermediate conformations between the opened enzyme structure and the closed liganded one were built by calculating a transition path with a method we developed. A wider range of chemical compounds could dock in the partially opened intermediate active site models ...
https://research.pasteur.fr/fr/publication/combined-approaches-for-drug-design-points-the-way-to-novel-proline-racemase-inhibitor-candidates-to-fight-chagas-disease/
dadA - D-amino acid dehydrogenase - Escherichia coli (strain K12) - dadA gene & proteindadA - D-amino acid dehydrogenase - Escherichia coli (strain K12) - dadA gene & protein
Catalyzes the oxidative deamination of D-amino acids. Has broad substrate specificity; is mostly active on D-alanine, and to a lesser extent, on several other D-amino acids such as D-methionine, D-serine and D-proline, but not on L-alanine. Participates in the utilization of L-alanine and D-alanine as the sole source of carbon, nitrogen and energy for growth. Is also able to oxidize D-amino acid analogs such as 3,4-dehydro-D-proline, D-2-aminobutyrate, D-norvaline, D-norleucine, cis-4-hydroxy-D-proline, and DL-ethionine.
http://www.uniprot.org/uniprot/P0A6J5
Amazon.com: SONGMICS Bamboo Shoe Rack Bench for Boots, Entryway Storage Organizer, 3 Tiers Shoe Shelf, Multi Function for...
Buy SONGMICS Bamboo Shoe Rack Bench for Boots, Entryway Storage Organizer, 3 Tiers Shoe Shelf, Multi Function for Hallway Bathroom Living Room Corridor and Garden, Brown: Storage Benches - Amazon.com ✓ FREE DELIVERY possible on eligible purchases
https://uedata.amazon.com/SONGMICS-Entryway-Organizer-Function-ULBS06Z/dp/B01NBVZDMH
RelB belongs to the family of Rel-related proteins, - awardban fun
Factors Associated with the Success of In Vitro Fertilization in Women with Inflammatory Bowel Disease. The aim of this study cialis daily was to review a series of consecutive patients managed at our unit at least 1 year prior to the onset of the study. Based on the new Ultralite-foil-crown the mechanical strength of the Ultralite-molar-crown is tested.. A single assay for simultaneously testing effectors of alanine racemase and/or D-alanine: D-alanine ligase. All three agents demonstrated anticancer activity at very low dosages compared with current clinically useful anticancer agents. Women that smoked had higher cialis 30 day trial coupon SRS scores as compared with female nonsmokers, and also higher than in males, smokers and nonsmokers. A retrospective study was performed in 38 cases of intussusception in 35 children over a 33-month cialis generic period at a pediatric hospital. Psychopedagogic rehabilitation of learning disorders in school children The main barrier to reduction of ...
http://awardban.fun/relb-belongs-to-the-family-of-rel-related-proteins/
Plus itPlus it
D-Cycloserine is a competitive inhibitor of alanine racemase for which its Ki is 100 times smaller than the Km for either of the substrates, D- and L-alanine. L-Cycloserine, however, does not inhibit this enzyme. A hypothesis is proposed, based on molecular models, that D-cycloserine has the conformation required of the substrates on the enzyme surface. L-Cycloserine cannot have this conformation.. ...
http://molpharm.aspetjournals.org/content/2/1/92
Solid Wood Coat Rack Entryway Hall Tree Coat Tree Rack for Coat Hat Pu - European Hand Tools
Sturdy solid wood construction tree stand--- prong legs design add balance stability coat rack convenient hooks allow diy assemble different length number layersModern design coat tree hanger holder --- match most home office eacute cor styles this floor rack perfect choice coats jackets handbags purses scarves umbrell
https://europeanhandtools.com/products/umbrella-stand-solid-wood-coat-rack-entryway-hall-tree-coat-tree-rack-for-c-b07cwt7d8b
June 8, 2020
Each time the machine is punched down, it makes one of the unmistakable indents in the key. Other cutting techniques are utilized by locksmiths to make new keys, however this the code machines fills in as a standard strategy, that for all intents and purposes each locksmith sees how to utilize. On the off chance that you have ever secured your keys in the vehicle of coincidentally went out, you realize that practically any locksmith can come and open your bolted entryway for you. There are various techniques utilized by proficient locksmiths, from thin Jims, to knock keys to copy keys. A decent locksmith ought to have the option to open your vehicle, house or other entryway without harming the lock or the property itself. In the event that the locksmith is messy and scratches your vehicle or damages your home lock, you would be shrewd to pick another service whenever around, as harm is not essential in any way. League City Locksmith services can put in new secures for you a convenient, ...
https://www.rdatransformation.com/2020/06/08
1:47 am
Items i 32 of Lay aside wish the placement of the dressing table and chairperson and repositing work bench astatine end of Like the idea of. And our bedrooms are downstairs. For entry closetold bedroom dresser Painted DIY Repurpose an old drawer into a incline set back with storage. 77 DIY work bench Ideas Storage Pallet Garden Cushion says Aug Coaster Classic Storage work bench with Nailhead reduce Design Tan Microfiber computer memory Bench For Bedroom.. Frame a storage work bench for the residence hall entryway operating room porch with i of the many release plans. SMLXL beginning woodworking classes front page bench plane Group A wooden storage work bench seat is the perfect every bit angstrom decorative and useful entryway beginners wood projects or sleeping accommodation storage and seating However for those that are handy you behind look up.. ...
http://shandy.crabdance.com/download-bedroom-storage-bench-plans-pdf-bench-vise/
tile - Exterior metal threshold to transition from concrete to tiled entryway? - Home Improvement Stack Exchangetile - Exterior metal threshold to transition from concrete to tiled entryway? - Home Improvement Stack Exchange
There is a significant issue with aluminum in concrete - e.g., an aluminum post or conduit embedded in concrete is not a good idea. My hunch is that a piece of aluminum on top of already cured concrete will not have the same issues. However, I am not a metallurgist and so, to play it safe, I would look for a similar piece of steel instead.. On the other hand, a quick search finds steel thresholds to be a bit on the expensive side. I suggest checking with an aluminum threshold manufacturer to see if installation on top of concrete is acceptable.. ...
https://diy.stackexchange.com/questions/207830/exterior-metal-threshold-to-transition-from-concrete-to-tiled-entryway
Honey Do Woodworking: Entryway Mirror ProgressHoney Do Woodworking: Entryway Mirror Progress
I tried to use my jack plane and shooting board to square up the end grain, but it was bothering my shoulder. Carolyn has said she wants to buy me the Lie-Nielsen No.51 Shooting Board Plane for Birthday/Christmas this year, but thats over a month and a half away. Not wanting to wait on the project I looked around for an alternative method for squaring up the ends of the boards ...
http://honeydowoodworking.blogspot.com/2012/11/entryway-mirror-progress.html
artisan gift box
Stack our Artisan Gift Boxes together on a mantel top, at an entryway, or beneath the boughs of your tree. Youll want one of each color for a complete collection.Perfectly sized for an entryway or hearthside displayEach is crafted from wood with antiqued red, green, or ivory finishAll three styles are adorned with aged-tin bows and holly accentsEach is individually handcrafted, so no two are .... ...
https://www.hotelmix.pl/21704/artisan/gift/box.html
Bow-front entryway table - by Jim Good @ LumberJocks.com ~ woodworking communityBow-front entryway table - by Jim Good @ LumberJocks.com ~ woodworking community
This was the third project I made at the Center for Furniture Craftsmanship in Rockport, Maine. I did the 12-week intensive there last winter. Great school, excellent instructors. This table has a hand-cut walnut veneered floating top, with Q-S ...
http://lumberjocks.com/projects/87124
Home - ALRA
With campuses in both London and Wigan, Greater Manchester, ALRA has an international reputation for providing comprehensive, rigorous training and is one of the top destinations for aspiring performing arts talent ...
https://alra.co.uk/?DramaGroups
Ember Wall Light by SPRK | Gantri ®Ember Wall Light by SPRK | Gantri ®
Introducing Ember Wall Light from SPRK, a new studio focused on creating sensual, at-home experiences after dark with provocative, detail oriented designs. Inspired by intimate moments and unforgettable nights, SPRK enhances allure with lighting that sets the mood. Ember Wall Light transforms the same design concepts of Discus into a whole new form factor. Ember adorns a spherical diffuser embedded into a geometric base that features Gantris innovative wall mount for simple install. Its also coupled with a versatile, built-in hook that allows for easy storage of your outerwear, keys or headphones. Ember is perfect for your entryway, offering guiding light to fuel your daily passions.
https://www.gantri.com/products/10090/ember-wall-light-by-sprk/10090-lg-forest
Eames Molded Plywood Folding Screen - Design Within ReachEames Molded Plywood Folding Screen - Design Within Reach
Shop Eames Molded Plywood Folding Screen and see our wide selection of Entryway Accessories at Design Within Reach. In stock, exclusive, and ready to ship -- authentic modern furniture from iconic designers.
https://www.dwr.com/entryway-accessories/eames-molded-plywood-folding-screen/663014.html?lang=en_US
Security Single Door 36 In. X 80 In. Heavy-duty Lockbox Copper Surface MountSecurity Single Door 36 In. X 80 In. Heavy-duty Lockbox Copper Surface Mount
The Unique Home Designs ArcadaMax Security Door adds extra security to any home. This door is made from steel with 1/2 in. Square-tube pickets for added stability and intruder deterrence.. The powder-coat finish complements the handsome design and coordinates well with a variety of exteriors. The perforated metal screen offers additional security and visibility. Made from steel for strength with a heavy-duty 2 in. Expanded metal screen provides visibility and ventilation. Square-tube, forged steel pickets in a classy arched design. Heavy-duty lockbox with 2-3/8 in. Protective powder-coat for a beautiful and durable finish. Reversible for left or right-handing allows versatility when installing. Surface mount door affixes to the face of entryway trim 1 in. Flat surface required for installation, see image in info and guides specifications. One-way screws and one-time-use one-way driver bit included. Use Unique Home Designs one-way screw drill bit driver for easier installation (not included). ...
http://dutysteelmount.com/en/security_single_door_36_in_x_80_in_heavy_duty_lockbox_copper_surface_mount.html
Composite Prototyping Center (CPC) - Campolo, Middleton & McCormick, LLPComposite Prototyping Center (CPC) - Campolo, Middleton & McCormick, LLP
Just off the LIE where Nassau and Suffolk meet sits the Composite Prototyping Center (CPC), a state-of-the-art, innovative entryway into Long Islands future. Unassuming from the outside, tucked into an industrial area on Express Street in Plainview, the visionary CPC uses cutting-edge composite technology that enables businesses to design and build virtually anything they can dream up. How can HIA-LIs members, particularly those in the robust manufacturing industry, benefit from this hidden jewel? HIA-LI Board Chairman Joe Campolo, President and CEO Terri Alessi-Miceli, and board member Dr. Ann-Marie Scheidt recently toured this visionary facility and met with some of its leaders and board members to find out.. ...
https://cmmllp.com/composite-prototyping-center-cpc/
Well-Being in our Sukkah « Congregation Beth MordecaiWell-Being in our Sukkah « Congregation Beth Mordecai
A - Accomplishments. Each of these elements can be measured, some subjectively and some more concretely, and they each contribute to our own sense of well-being. I wonder if this what the Torah and our sages of blessed memory mean when they describe this holiday as zman simchateinu. Maybe its not simply about life satisfaction but in fact about well-being and flourishing.. Lets see if by using our sukkot we might make some gains in the five elements of PERMA.. P-Positive Emotion - Just walking into a sukkah changes my mood. Even getting my sweaters out of storage for nighttime sukkah sitting makes me feel good. Its hard to describe but somewhere between being outside but not really, the decorations and the lights, the new years cards hung on the walls, the mention of historic and contemporary ushpizin - holy invited guests - just makes me feel great.. E-Engagement - When I am in a sukkah, I find it easier to be in the flow. As if by some magic, crossing the threshold of the entryway elevates ...
http://bethmordecai.org/rabbis-journal/well-being-in-our-sukkah/
6 Tier Shoe Rack, White - Click! Design That Fits6 Tier Shoe Rack, White - Click! Design That Fits
Sleek and modern shoe rack, perfect for your entryway. The top shelf is just right for storing your keys and the optional (included) hook keeps your shoe-horn or umbrella at the ready. 6 tier shoe rack measures 34.3
https://clickdesignthatfits.com/collections/home-accessories/products/6-tier-shoe-rack-white
153 Ornate Avenue, Fairhope Al, 36532, Fairhope, AL, United States being shown by Bellator Real Estate & Development with MLS #...153 Ornate Avenue, Fairhope Al, 36532, Fairhope, AL, United States being shown by Bellator Real Estate & Development with MLS #...
Welcome home to the Macon Plan by Truland Homes in The Tracery. This home comes tons of upgrades including wood flooring throughout the living, dining, kitchen area, granite counters in kitchen and master bath, gas log fireplace in the family room, custom-crafted cabinets throughout with painted upgrade in the kitchen, and ceramic tiled shower in master bath. From this impressive entryway into the great room with its 10 foot ceiling surrounded by crown molding, it will catch your breath at the airy open space for living, dining, and entertaining. Planning, preparing and sharing meals here in the spacious island in the kitchen connected to a large breakfast area can be a joy. A roomy master sanctuary with vaulted ceiling and a bathroom with double vanities also his & her closets. Gather around the cozy corner fireplace, a comfort on cool southern evenings. Live surrounded by the tasteful finishes youve come to expect from a Truland Home, a solace after a day out in the world. Wood flooring, painted
https://www.leadingre.com/listings/b5e18cd5-1a55-4b41-be63-b186d11e091f/153-ornate-avenue-fairhope-al-36532-fairhope-36532
http://ufdc.ufl.edu/IR00001720/00001http://ufdc.ufl.edu/IR00001720/00001
Salvaging Hurricane-Damaged Palms in the Nursery 2 dying. This may not be feasible for field nurseries without irrigation, but rainfall may be adequate to keep rootballs moist. If the trunk of a single-stemmed (versus clustering or clumping) palm is broken, whether completely severed at the base or anywhere along its length, splintered or sharply bent (kinked) at some point along its length -that palm is unredeemably damaged and cannot be save. Palm stems have no ability to heal as do broad-leaved trees. Clustering or clumping palms, however, continuously produce new stems and should not be removed, even if all the conspicuous, tall stems are badly damaged. Broken stems of a clustering palm should be carefully cut as close to their base as possible. Application of a fungicide after this operation is recommended, since the stumps can provide entryway for disease organisms. Even though a palm may have been left standing after the hurricanes passage, severe stresses to the crown and, most ...
http://ufdc.ufl.edu/IR00001720/00001
Hand Crafted Ketchikan Double-Wide Radius-Head Entry Doors by Christies Wood and Glass | CustomMade.comHand Crafted Ketchikan Double-Wide Radius-Head Entry Doors by Christies Wood and Glass | CustomMade.com
Made from Ponderosa pine with a Driftwood finish, this entryway is 62 wide x 83 high. The asymmetrical design has three inulated, beveled glass pan…
https://www.custommade.com/ketchikan-double-wide-radius-head-entry-doors/by/christieswoodandglass/
HONEY 70X350 - Classic with a TwistHONEY 70X350 - Classic with a Twist
The Honey Rug is a beautifully designed rug with a bold honeycomb geometric pattern on the front and back. This makes a perfect entryway rug, as a hallway runner or as a mud room mat. Its durable, easy to maintain and features a reversible design that works as well indoors as it does out - making it a great choice for
https://classicwithatwist.com.au/products/honey-70x350-6
WAN:: New Abuja City Gate by Ehrlich Architects in Abuja, NigeriaWAN:: New Abuja City Gate by Ehrlich Architects in Abuja, Nigeria
The New Abuja City Gate provides a dynamic entryway to Nigerias new capital city, serving multiple symbolic and practical functions. The iconic design of the Gates tower and pedestrian bridge creates an international landmark that points the way
http://www.worldarchitecturenews.com/index.php?fuseaction=wanappln.showprojectbigimages&img=1&pro_id=14335
shoes cube organizer - foaqashoes cube organizer - foaqa
DescriptionIntroduction: a stylish design shoe rack adds a touch of style to entryway or bedroom. It is great and practical in use for home and office. We strongly recommend this portable shoe rack which is perfect for organizing shoes, classic designed, highly funtional and collapsible for easy transportation. Really
https://foaqa.com/products/shoes-cube-organizer
Classic Border Monogrammed Coco Door Mat | FrontgateClassic Border Monogrammed Coco Door Mat | Frontgate
Framed in a sophisticated, bold border, our Classic Border Monogrammed Coco Door Mat graces an entryway with your single initial. Constructed of 100% durable coir fibers, this handsome mat is stenciled in fade-resistant dyes for long-lasting luxury. Stenciled in fade-resistant dyes Constructed of 100% coir fibers Protects your floors from mud, sand, water, and dirt 1-1/2 thick View complete care instructionsDo not place in area where it will remain wet for long periods of time with no sunlight for dryingThe natural dyes can produce a brown stain that is difficult to remove from certain surfaces; using a rug pad is recommendedNot recommended for use on slate, granite, cobblestone, or limestone porches that have been chemically sealed If you are not satisfied with this specific monogrammed item, you may return it within 90 days, and well replace it or refund the cost (excluding Shipping and Handling fees).
https://www.frontgate.com/classic-border-monogrammed-coco-door-mat/695759?bvstate=pg:2/ct:q
Melinda Loomis: May 2019
The highlight for us was the last house we hit on the tour, the beautiful Victorian known as Idlewild, which just happens to be for sale. It was also the only multi-level home where we werent allowed upstairs, which was disappointing, plus I wasnt overwhelmed by the kitchen, but the rest of it was impressive as hell. The entryway is gorgeous and the wooden arch between the living room and dining room was absolutely stunning (the picture on the listing doesnt do it justice). I think The Brother was still kind of meh about it until we got outside and were directed to the wine cellar, which is only accessible from the side yard. I think that sold it for him. Probably a good thing he doesnt have a spare $1.7 million laying around. They also wisely didnt have any actual wine in there so we didnt have to fight off the temptation to make off with a souvenir ...
http://www.melindaloomis.com/2019/05/
UofL Libraries Digital Collections
Exterior of the Louisville Service Club building located at 525 S. 5th St. in Louisville, Ky. The multi story building has a stone facade and a metal awning over the entryway along the first floor. Along the side of the building is a painted sign ...
http://digital.library.louisville.edu/cdm/search/searchterm/%20Soldiers/field/subjec/mode/exact/order/subjec/page/13
The Welcome Home Olive WreathThe Welcome Home Olive Wreath
Theres no better way to welcome guests than with a modern wreath adding warmth to your entryway. Whether youre hosting a dinner party for friends or in need of a housewarming gift to congratulate their next big move, this olive wreaths green leaves and branches are beautiful and inviting. ...
https://www.proflowers.com/product/the-welcome-home-olive-wreath-prd-p2276?ref=PFCFeedGoogle
Court Rules for Dog-Killing Cop in Judgment in Rule 50 Appeal - FindLawCourt Rules for Dog-Killing Cop in Judgment in Rule 50 Appeal - FindLaw
In 2006, Deputy James Carroll and other officers from the Greater Rochester Area Narcotics Enforcement Team executed a no-knock warrant for Sherry Carrolls home. Deputy Carroll, who was in charge of securing the entryway, was the first to enter the house. Thats when he saw a dog growling, barking, and quickly and aggressively approaching. Once the dog had advanced to within a foot of him, Deputy Carroll fired one shot from his shotgun at the animals head and killed him.
https://www.findlaw.com/legalblogs/second-circuit/court-rules-for-dog-killing-cop-in-judgment-in-rule-50-appeal/
I GOT UP Hot Wheels / Athens | | Flash...I GOT UP Hot Wheels / Athens | | Flash...
Four identical postcards displayed in the gallerys entryway bear the stamped, enigmatic phrase I GOT UP AT, followed by the time that the sender awoke.
https://flash---art.com/2021/08/i-got-up-hot-wheels-athens/
Roots Planted in Dallas with a Custom Map Poster - Color & ChicRoots Planted in Dallas with a Custom Map Poster - Color & Chic
Upon coming home, seeing my custom map poster of Dallas on my entryway console brings a smile to my face. Its a little piece of home I can enjoy far away.
http://colorandchic.com/roots-planted-in-dallas-custom-map-poster/
Horned Skull Door KnockerHorned Skull Door Knocker
When you wish to have a truly foreboding home or simply wish to have a dark aesthetic for your entryway, consider using the Horned Skull Door Knocker.
https://www.medievalcollectibles.com/product/horned-skull-door-knocker/
UofL Libraries Digital Collections
Address: 1705 Stevens Avenue. Kings Daughters and Sons Home (Home for Incurables) sits at the corner of Stevens Avenue and Quadrant Avenue in 1928. It is a three-story brick building with a staircase to the front entryway and a small front porch ...
http://digital.library.louisville.edu/cdm/search/field/descri/searchterm/diseases
Sundsvall Console Table - Black | HayneedleSundsvall Console Table - Black | Hayneedle
Crafted from solid beechwood, the Sundsvall Console Table - Black will bring both style and grace to your living room, entryway, or foyer....
https://www.hayneedle.com/product/sundsvallconsoletable.cfm
BALENTINE MEMOIRS: On wisdomBALENTINE MEMOIRS: On wisdom
Wisdom tells me that happiness is temporary, fleeting. Happiness is a decision on how to react to the circumstances right in front of you. Teddy is an amazing example of reacting with either happiness or sadness to the thing that is right in front of his face. Last night when we picked up Teddy at my parents house, we brought everyone some chocolate chip cookies that we could all share together. We walked in my parents house through door off the garage and were greeted by Teddy (and Sophie the bop bop). Within seconds, Teddys gaze moved to cookies. He nodded vigorously, gasped excitedly, said Dees! Dees! (which seems to be an efficient combination of this, these and please), and sat right down on the floor in the entryway as if to say, Lets do this. Right here. Right now. We had not even shut the door behind us to come inside yet! Of course, we caved in and gave Teddy a cookie, but at least made him stand up and walk into the kitchen. His body wiggled with happiness, and he made grunts of ...
http://www.balentinememoirs.com/2014/02/on-wisdom.html
Just through the portal | Lifeonthecutoffs BlogJust through the portal | Lifeonthecutoffs Blog
While icy cold still pervades here on the Cutoff, temperatures have climbed a bit above freezing and the sun has shown its face enough to encourage icicles to form. These frozen daggers have sculpted themselves above our entryway; that back door portal of our comings and goings in our daily life. It was Tuesday morning,…
https://lifeonthecutoff.wordpress.com/2013/12/18/just-through-the-portal/
Important Strategies Big Brands Implement With Influencers - Cem Neuilly SurmarneImportant Strategies Big Brands Implement With Influencers - Cem Neuilly Surmarne
This is 2018 and individuals are looking for data from those they trust or see as specialists. That is the thing that makes Influencer App Business so important. It opens the entryway for real stories and encounters to form around brands in a manner that cannot be cultivated through different kinds of publicizing.. Assuming youve been reluctant to venture out into Influencer App Business, ideally these five techniques that enormous brands execute will adjust your perspective.. Famous people or No Celebrities? That is the Question.. It is a good idea to imagine that if a brand employed a big name with a huge number of adherents, their mission would be more fruitful in light of the fact that it is anything but a bigger crowd.. However, this could not possibly be more off-base.. Late examination has shown that commitment really begins to diminish as devotee tallies develop. In the wake of assessing more than 800,000 Instagram clients, Markerly found that those with 1,000 or less adherents had a 8% ...
https://cem-neuillysurmarne.com/important-strategies-big-brands-implement-with-influencers.htm
Front Door Decorations That Celebrate Everything We Love About Fall | Martha StewartFront Door Decorations That Celebrate Everything We Love About Fall | Martha Stewart
Give your front door an autumnal update with these DIY decorating ideas. Browse our gallery of fall entryway ideas for creative wreaths and more.
https://www.marthastewart.com/1125867/front-door-decorations-celebrate-love-fall
Project: Write your own eulogy!Project: Write your own eulogy!
You know what sometimes makes me a little sad? If you ride SEPTA you know the strangely accented woman who voices the stops on the Broad Street line. A couple years ago I became hyper aware of the particular announcement she gives just before the metal entryway slides shut and the car starts to pull…
https://swimpony.org/2013/03/01/project-write-your-own-eulogy/
June 2019 - Sweet Earth Organic FarmJune 2019 - Sweet Earth Organic Farm
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http://www.sweetearthorganicfarm.com/2019/06
CallanishCallanish
At the start of my tour, Margaret took me to her workshop, where she demonstrated how the Callanish stone circles were designed to be ellipses-not just poorly made circle-and how the stones were erected. She even let me hold a 4,000-year-old arrowhead-a tiny remnant of the prehistoric people who lived on this island. Mind-boggling!. Later, we ambled through Callanish I, the main stone ellipsis, which Margaret calls both a stone-age computer (because it marks solar and lunar events) and a community center (because it was a gathering place for singing, dancing, and burying the dead).. In a way, Callanish is still a community center-of World Heritage Site calibre. Over the days, I heard visitors from several continents speaking various languages, and I watched children have foot-races down the stone-lined avenue, the ancient entryway to the main circle. I saw photographers and artists capturing images of the stones on paper or in digital format. Couples paused to kiss. Baaing sheep gazed over ...
https://www.laurelkallenbach.com/lkblog/tag/callanish/
40 IKEA Malm Dresser Hacks | ComfyDwelling.com40 IKEA Malm Dresser Hacks | ComfyDwelling.com
IKEA Malm dresser is a cool piece that can fit any bedroom, closet, entryway or any other room. Taken in white, its perfect for most of modern interiors ...
http://comfydwelling.com/furniture/40-ikea-malm-dresser-hacks-that-fit-every-space.html/comment-page-62
D-ALANINE (2,3-13C2, 99%) - Creative Proteomics
Creative-Proteomics offer cas 338-69-2 D-ALANINE (2,3-13C2, 99%). We are specialized in manufacturing Stabel Isotope Labeled Analytical Standard products.
https://www.creative-proteomics.com/product/detail-cpil100340_29403.htm
D-ALANINE (3-13C, 99%) - Creative Proteomics
Creative-Proteomics offer cas 338-69-2 D-ALANINE (3-13C, 99%). We are specialized in manufacturing Stabel Isotope Labeled Analytical Standard products.
https://www.creative-proteomics.com/product/detail-cpil101562_29366.htm
Alanine racemaseAlanine racemase
... can be found in some invertebrates. Bacteria can have one (alr gene) or two alanine racemase genes. Bacterial ... The systematic name of this enzyme class is alanine racemase. This enzyme is also called L-alanine racemase. This enzyme ... The D-alanine produced by alanine racemase is used for peptidoglycan biosynthesis. Peptidoglycan is found in the cell walls of ... In enzymology, an alanine racemase (EC 5.1.1.1) is an enzyme that catalyzes the chemical reaction L-alanine ⇌ {\displaystyle \ ...
https://en.wikipedia.org/wiki/Alanine_racemase
AlanineAlanine
Fermentation routes to L-alanine are complicated by alanine racemase. Racemic alanine can be prepared by the condensation of ... is so-called alanine scanning, where every position in turn is mutated to alanine. Hydrogenation of alanine gives the amino ... forming alanine and α-ketoglutarate. The alanine enters the bloodstream, and is transported to the liver. The alanine ... Alanine (symbol Ala or A), or α-alanine, is an α-amino acid that is used in the biosynthesis of proteins. It contains an amine ...
https://en.wikipedia.org/wiki/Alanine
Diaminopimelate decarboxylaseDiaminopimelate decarboxylase
DAPDC is a PLP-dependent enzyme belonging to the alanine racemase family. This enzyme is generally dimeric with each monomer ... "Functional classification of amino acid decarboxylases from the alanine racemase structural family by phylogenetic studies". ...
https://en.wikipedia.org/wiki/Diaminopimelate_decarboxylase
CiclosporinCiclosporin
The racemization of L-Ala to D-Ala by alanine racemase is pyridoxal phosphate-dependent. The formation of butenyl-methyl-L- ... Of these 12 genes, SimA (Q09164) is the cyclosporin synthetase, SimB (CAA02484.1) is the alanine racemase, and SimG (similar to ... di Salvo ML, Florio R, Paiardini A, Vivoli M, D'Aguanno S, Contestabile R (January 2013). "Alanine racemase from Tolypocladium ... Cyclosporin synthetase substrates include L-valine, L-leucine, L-alanine, glycine, 2-aminobutyric acid, 4-methylthreonine, and ...
https://en.wikipedia.org/wiki/Ciclosporin
Tolypocladium inflatumTolypocladium inflatum
The expression levels of alanine racemase affects the level of cyclosporine production by T. inflatum. Ciclosporin A was first ... "Alanine racemase from Tolypocladium inflatum: A key PLP-dependent enzyme in cyclosporin biosynthesis and a model of catalytic ...
https://en.wikipedia.org/wiki/Tolypocladium_inflatum
Mycobacterium lepraeMycobacterium leprae
... and one of them is alanine racemase (alr). This enzyme is significant because it is found in D-alanine-D-alanine ligase and ... alanine/Aspartate metabolism. Other essential enzymes include putative dTDP4deydrorhamnose 3, 5epimerase (rm1C) which plays an ...
https://en.wikipedia.org/wiki/Mycobacterium_leprae
Pyridoxal phosphatePyridoxal phosphate
AlaP (alanine phosphonate) inhibits alanine racemases, but its lack of specificity has prompted further designs of ALR ... D-alanine aminotransferase family and the alanine racemase family. An example of the evolutionary similarity in the Beta family ... Fold Type I - aspartate aminotransferase family Fold Type II - tryptophan synthase family Fold Type III - alanine racemase ... 2011). Ahmed N (ed.). "New classes of alanine racemase inhibitors identified by high-throughput screening show antimicrobial ...
https://en.wikipedia.org/wiki/Pyridoxal_phosphate
D-threonine aldolaseD-threonine aldolase
"Threonine aldolase and alanine racemase: novel examples of convergent evolution in the superfamily of vitamin B6-dependent ...
https://en.wikipedia.org/wiki/D-threonine_aldolase
Dan T. MajorDan T. Major
"A Combined Quantum Mechanical and Molecular Mechanical Study of the Reaction Mechanism and α-Amino Acidity in Alanine Racemase ...
https://en.wikipedia.org/wiki/Dan_T._Major
ExosporiumExosporium
Seven proteins have been identified in washed exosporium: alanine racemase, inosine hydrolase, ExsF, CotY, ExsY, CotB, and a ...
https://en.wikipedia.org/wiki/Exosporium
Orientia tsutsugamushiOrientia tsutsugamushi
... alr encodes an enzyme L-alanine racemase, which converts L-alanine to D-alanine in the first step of peptidoglycan synthesis ...
https://en.wikipedia.org/wiki/Orientia_tsutsugamushi
CycloserineCycloserine
... alanine racemase (Alr) and D-alanine:D-alanine ligase (Ddl). The first enzyme is a pyridoxal 5'-phosphate-dependent enzyme ... Lambert MP, Neuhaus FC (June 1972). "Mechanism of D-cycloserine action: alanine racemase from Escherichia coli W". Journal of ... If both of these enzymes are inhibited, then D-alanine residues cannot form and previously formed D-alanine molecules cannot be ... Prosser GA, de Carvalho LP (February 2013). "Kinetic mechanism and inhibition of Mycobacterium tuberculosis D-alanine:D-alanine ...
https://en.wikipedia.org/wiki/Cycloserine
List of MeSH codes (D08)List of MeSH codes (D08)
... alanine racemase MeSH D08.811.399.894.500 - carbohydrate epimerases MeSH D08.811.399.894.500.700 - UDP-glucose 4-epimerase MeSH ... beta-alanine-pyruvate transaminase MeSH D08.811.913.477.700.347 - d-alanine transaminase MeSH D08.811.913.477.700.470 - ... alanine-tRNA ligase MeSH D08.811.464.263.200.100 - arginine-tRNA ligase MeSH D08.811.464.263.200.150 - aspartate-tRNA ligase ... alanine dehydrogenase MeSH D08.811.682.664.500.125 - d-amino-acid oxidase MeSH D08.811.682.664.500.261 - d-aspartate oxidase ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D08)
List of EC numbers (EC 5)List of EC numbers (EC 5)
EC 5.1.1.1: alanine racemase EC 5.1.1.2: methionine racemase EC 5.1.1.3: glutamate racemase EC 5.1.1.4: proline racemase EC 5.1 ... allantoin racemase EC 5.1.99.4: α-methylacyl-CoA racemase EC 5.1.99.5: hydantoin racemase EC 5.1.99.6: NAD(P)H-hydrate ... lactate racemase EC 5.1.2.2: mandelate racemase EC 5.1.2.3: 3-hydroxybutyryl-CoA epimerase EC 5.1.2.4: acetoin racemase EC 5.1. ... arginine racemase EC 5.1.1.10: amino-acid racemase EC 5.1.1.11: phenylalanine racemase (ATP-hydrolysing) EC 5.1.1.12: ornithine ...
https://en.wikipedia.org/wiki/List_of_EC_numbers_(EC_5)
Enterococcus faecalisEnterococcus faecalis
D-alanine-D-serine ligase, alanine racemase, phosphate acetyltransferase, NADH peroxidase,Phosphopantetheine ... Glutamate racemase, hydroxymethylglutaryl-CoA synthase, diphosphomevalonate decarboxylase, topoisomerase DNA gyrase B, ...
https://en.wikipedia.org/wiki/Enterococcus_faecalis
SiminovitchiaSiminovitchia
... iron-sulphur cluster-binding protein and alanine racemase, which in most cases are exclusively shared by either all or most ...
https://en.wikipedia.org/wiki/Siminovitchia
Aspartate racemaseAspartate racemase
It was then determined that aspartate racemase also racemizes L-alanine around half as quickly as it does L-aspartate, but does ... proline racemase, and hydroxyproline-2-epimerase. Mammalian aspartate racemase, in contrast with bacterial aspartate racemase, ... First, D-aspartate is isomerized to L-aspartate by aspartate racemase, followed by decarboxylation to form L-alanine. D-amino ... Notably, aspartate racemase in E. coli is also able to catalyze the racemization of glutamate. In 2004, an aspartate racemase ...
https://en.wikipedia.org/wiki/Aspartate_racemase
Epimerase and racemaseEpimerase and racemase
Human epimerases include methylmalonyl-CoA epimerase, involved in the metabolic breakdown of the amino acids alanine, ... Racemases catalyze the stereochemical inversion around the asymmetric carbon atom in a substrate having only one center of ... Epimerases and racemases are isomerase enzymes that catalyze the inversion of stereochemistry in biological molecules. ... "Isomerase , enzyme , Britannica". http://medical-dictionary.thefreedictionary.com/racemase http://medical-dictionary. ...
https://en.wikipedia.org/wiki/Epimerase_and_racemase
D-Amino acidD-Amino acid
D-alanine. L-alanine. L- and D-amino acids are usually enantiomers. The exceptions are two amino acids with two stereogenic ... D-Amino-acid racemase, a PLP-dependent enzyme, racemizes amino acids via the formation of the alpha-iminoacids, where the ... The D-alanine in peptidoglycans that comprise bacterial cell walls helps its host resist attack by proteolytic enzymes. Several ... They have been known to synthesize more than 10 kinds of D-amino acids, most frequently D-alanine and D-glutamate for ...
https://en.wikipedia.org/wiki/D-Amino_acid
D-amino-acid transaminaseD-amino-acid transaminase
Other names in common use include D-aspartate transaminase, D-alanine aminotransferase, D-aspartic aminotransferase, D-alanine- ... "Characterization of the genes encoding D-amino acid transaminase and glutamate racemase, two D-glutamate biosynthetic enzymes ... In enzymology, a D-amino-acid transaminase (EC 2.6.1.21) is an enzyme that catalyzes the chemical reaction: D-alanine + 2- ... Martinez-Carrion M, Jenkins WT (1965). "D-Alanine-D-glutamate transaminase. I. Purification and characterization". J. Biol. ...
https://en.wikipedia.org/wiki/D-amino-acid_transaminase
NMDA receptorNMDA receptor
... endogenous glycine site agonist Alanine (D-alanine, L-alanine) - endogenous glycine site agonist Milacemide - synthetic glycine ... It is produced by serine racemase, and is enriched in the same areas as NMDA receptors. Removal of D-serine can block NMDA- ... 1 takes part to the Ca2+-related prosurvival pathway of SOD1 in primary motor neurons exposed to beta-methylamino-L-alanine". ...
https://en.wikipedia.org/wiki/NMDA_receptor
Vitamin B6Vitamin B6
The DXP-dependent pathway: The starting material is either the amino acid alanine, or propionic acid converted into alanine via ... Serine racemase which synthesizes the neuromodulator D-serine from its enantiomer is a PLP-dependent enzyme. PLP is a coenzyme ...
https://en.wikipedia.org/wiki/Vitamin_B6
List of enzymesList of enzymes
EC 5.1.1 Amino-acid racemase: Phenylalanine racemase (ATP-hydrolysing) Serine racemase Category:EC 5.1.2 Mandelate racemase ... EC 2.6.1 Alanine transaminase EC 2.6.1.2 Aspartate transaminase EC 2.6.1.1 Category:EC 2.7.2 Butyrate kinase (EC 2.7.2.7) EC ... D-alanine-D-alanyl-carrier protein ligase EC 6.2.1.55: E1 SAMP-activating enzyme Glutamine synthetase (EC 6.3.1.2) ... EC 3.4.11 Alanine aminopeptidase Category:EC 3.4.15 Angiotensin converting enzyme Category:EC 3.4.21 Serine protease ...
https://en.wikipedia.org/wiki/List_of_enzymes
Glutamic acidGlutamic acid
Examples are as follows: Alanine + α-ketoglutarate ⇌ pyruvate + glutamate Aspartate + α-ketoglutarate ⇌ oxaloacetate + ... which can manufacture it from the l form with the enzyme glutamate racemase) and the liver of mammals. Although they occur ...
https://en.wikipedia.org/wiki/Glutamic_acid
Non-proteinogenic amino acidsNon-proteinogenic amino acids
Examples include β-alanine, GABA, and δ-aminolevulinic acid. β-alanine: an amino acid produced by aspartate 1-decarboxylase and ... serine racemase from vancomycin-resistant Enterococcus gallinarum BM4174". Molecular Microbiology. 31 (6): 1653-1664. doi: ... alanine aminoisobutyric acid dehydroalanine A subset of L-α-amino acids are ambiguous as to which of two ends is the α-carbon. ... This compound is similar to alanine, but possesses an additional methyl group on the α-carbon instead of a hydrogen. It is ...
https://en.wikipedia.org/wiki/Non-proteinogenic_amino_acids
MorpheeinMorpheein
Ashiuchi, M.; Kuwana, E; Yamamoto, T; Komatsu, K; Soda, K; Misono, H (2002). "Glutamate Racemase is an Endogenous DNA Gyrase ... Schulz, Ju¨Rgen; Sparmann, Gisela; Hofmann, Eberhard (1975). "Alanine-mediated reversible inactivation of tumour pyruvate ... Ashiuchi, M.; Tani, K.; Soda, K.; Misono, H. (1998). "Properties of Glutamate Racemase from Bacillus subtilis IFO 3336 ... 2007). "Structural and Functional Analysis of Two Glutamate Racemase Isozymes from Bacillus anthracis and Implications for ...
https://en.wikipedia.org/wiki/Morpheein
alanine racemase造句 用alanine racemase造句alanine racemase造句 用"alanine racemase"造句
... or two alanine racemase genes. 2. The traditional mechanism attributed to an alanine racemase reaction is that of a two-base ... alanine racemase的造句和例句： 1. Bacteria can have one ( alr gene ) ... mechanism with a PLP-stabilized carbanion intermediate.点击查看更多alanine racemase的造句... ... Bacteria can have one ( alr gene ) or two alanine racemase genes.. *The traditional mechanism attributed to an alanine racemase
http://www.ichacha.net/mzj/alanine%20racemase.html
Structural insights into the alanine racemase from Enterococcus faecalis<...
title = "Structural insights into the alanine racemase from Enterococcus faecalis",. abstract = "Alanine racemase (AlaR) is a ... N2 - Alanine racemase (AlaR) is a bacterial enzyme that belongs to the fold-type III group of pyridoxal 5′-phosphate (PLP)- ... AB - Alanine racemase (AlaR) is a bacterial enzyme that belongs to the fold-type III group of pyridoxal 5′-phosphate (PLP)- ... Alanine racemase (AlaR) is a bacterial enzyme that belongs to the fold-type III group of pyridoxal 5′-phosphate (PLP)-dependent ...
https://koreauniv.pure.elsevier.com/en/publications/structural-insights-into-the-alanine-racemase-from-enterococcus-f
A Novel PLP-Dependent Alanine/Serine Racemase From the Hyperthermophilic Archaeon Pyrococcus horikoshii OT-3 - Bioscience and...
A Novel PLP-Dependent Alanine/Serine Racemase From the Hyperthermophilic Archaeon Pyrococcus horikoshii OT-3 ... A Novel PLP-Dependent Alanine/Serine Racemase From the Hyperthermophilic Archaeon Pyrococcus horikoshii OT-3 ... The enzyme was therefore designated Ala/Ser racemase (ASR). Like BAR, ASR was highly stable at high temperatures and over a ... In this study, we detected pyridoxal 5-phosphate (PLP)-dependent amino acid racemase activity in the protein encoded by PH0782 ...
https://repo.lib.tokushima-u.ac.jp/en/list/department/Bioscience%20and%20Bioindustry,%E7%94%9F%E7%89%A9%E8%B3%87%E6%BA%90%E7%B3%BB/83698/item/114287
Thermostable Alanine Racemase from Bacillus Stearothermophilus: DNA and Protein Sequence Determination and Secondary Structure...
The alanine racemase gene consists of 1158 base pairs encoding a protein of 386 amino acid residues; the molecular weight of ... The alanine racemase gene consists of 1158 base pairs encoding a protein of 386 amino acid residues; the molecular weight of ... The alanine racemase gene consists of 1158 base pairs encoding a protein of 386 amino acid residues; the molecular weight of ... The alanine racemase gene consists of 1158 base pairs encoding a protein of 386 amino acid residues; the molecular weight of ...
https://okayama.pure.elsevier.com/en/publications/thermostable-alanine-racemase-from-bacillus-stearothermophilus-dn
Pyridoxal phosphate - WikipediaPyridoxal phosphate - Wikipedia
AlaP (alanine phosphonate) inhibits alanine racemases, but its lack of specificity has prompted further designs of ALR ... alanine aminotransferase family and the alanine racemase family. An example of the evolutionary similarity in the Beta family ... "New classes of alanine racemase inhibitors identified by high-throughput screening show antimicrobial activity against ... liver cysteine desulfhydrase activity disappears and serine and threonine dehydrase and alanine glutamate transaminase ...
https://en.wikipedia.org/wiki/Pyridoxal_phosphate
Impairment of d-alanine biosynthesis in Mycobacterium smegmatis determines decreased intracellular survival in human...Impairment of d-alanine biosynthesis in Mycobacterium smegmatis determines decreased intracellular survival in human...
... a reaction catalysed by d-alanine racemase (Alr). Mycobacterium smegmatis alr insertion mutants are not dependent on d-alanine ... The primary route of d-alanine biosynthesis in eubacteria is the enantiomeric conversion from l-alanine, ... In this study, we demonstrate that the M. smegmatis alr insertion mutant TAM23 can synthesize d-alanine at lower levels than ... d-Alanine supplementation considerably increased TAM23 viability in nutritionally deficient media and within macrophages. These ...
https://www.microbiologyresearch.org/content/journal/micro/10.1099/mic.0.024901-0
HOMD :: SEQF2617HOMD :: SEQF2617
alanine racemase. 135. SEQF2617,KI669434.1. ETD24276.1 jb [NA] [AA] 429/142. 14531-14103. hypothetical protein. ...
https://www.homd.org/genome/explorer?gid=SEQF2617&anno=ncbi
Display 100 results per pageDisplay 100 results per page
... from both the alanine racemase (AR) and aspartate aminotransferase (AAT) folds. Two homologous forms of AAT-fold decarboxylase ...
https://www.jbc.org/Metabolism?startPage=0&pageSize=100
"sequence id","alias","species","description",...
... "alanine racemase 2 [Ensembl]. Alanine racemase [Interproscan].","protein_coding" "AAL20718","STM1803","Salmonella enterica","D- ... "alanine racemase [Ensembl]. N-terminal domain, C-terminal domain [InterProScan].","protein_coding" "AGT23716","N559_1989"," ... D-alanyl-D-alanine carboxypeptidase [Interproscan].","protein_coding" "AAC73941","potF","Escherichia coli","putrescine ABC ... ","D-alanine/D-serine/glycine transport protein [Ensembl]. Amino acid permease/ SLC12A domain [InterProScan].","protein_coding ...
https://bacteria.sbs.ntu.edu.sg/go/sequences/table/10511
Difference between revisions of "Methanococcus maripaludis" - microbewiki
Also, this species is able to use L- and D- Alanine as a nitrogen source utilizing alanine dehydrogenase and alanine racemase ...
https://microbewiki.kenyon.edu/index.php?title=Methanococcus_maripaludis&diff=prev&oldid=25001
New TB Drugs Possible With Understanding of an Old AntibioticNew TB Drugs Possible With Understanding of an Old Antibiotic
The drug attacks bacteria by inhibiting two separate enzymes (D-alanine racemase and D-alanine--D-alanine ligase) each required ... With the D-alanine racemase enzyme, it is known that the drug forms a molecular bond with a chemical group required for the ... The researchers have observed, for the first time, how D-cycloserine inhibits the D-alanine-D-alanine ligase enzyme. ... we see that D-cycloserine binds to the D-alanine-D-alanine ligase enzyme and becomes chemically modified on the enzyme. The ...
https://www.infectioncontroltoday.com/view/new-tb-drugs-possible-understanding-old-antibiotic
15+ Isomerase Enzyme Example: Detailed Facts - Lambda Geeks15+ Isomerase Enzyme Example: Detailed Facts - Lambda Geeks
7. Alanine racemase. An alanine racemase is a catalyzing enzyme for a chemical process. This enzyme is a member of the ... Methionine racemase. An isomerase enzyme called methionine racemase stimulates the chemical change. Pyridoxal phosphate is the ... Maleate isomerase, also known as maleate cis-trans isomerase, is a bacterial member of the Glu racemase superfamily. It is a ... isomerase family, particularly racemases and epimerases that operate on amino acids and other derivatives. ...
https://lambdageeks.com/isomerase-enzyme-example/
New tuberculosis drugs possible with understanding of old antibioticNew tuberculosis drugs possible with understanding of old antibiotic
The drug attacks bacteria by inhibiting two separate enzymes (D-alanine racemase and D-alanine-D-alanine ligase) each required ... With the D-alanine racemase enzyme, it is known that the drug forms a molecular bond with a chemical group required for the ... "In this new discovery, we see that D-cycloserine binds to the D-alanine-D-alanine ligase enzyme and becomes chemically modified ... The researchers have observed, for the first time, how D-cycloserine inhibits the D-alanine-D-alanine ligase enzyme. ...
https://medicalxpress.com/news/2017-12-tuberculosis-drugs-antibiotic.html
Team:Bielefeld-Germany/Datapage - 2013.igem.orgTeam:Bielefeld-Germany/Datapage - 2013.igem.org
Alanine racemase (alr) under the control of the Ptac promoter: Testing part for the complementation of the alanine racemase ( ... Alanine racemase from E. coli: Catalyzes the reversible isomerization from L-alanine into the enatiomer D-alanine. In an D- ... bbpart,BBa_K1172903,/bbpart, - Alanine racemase (alr) with double terminator: Cloning intermediate of the construction of the ... bbpart,BBa_K1172909,/bbpart, - Biosafety System araCtive: Biosafety System taking advantage of the alanine racemase and the ...
https://2013.igem.org/wiki/index.php?title=Team:Bielefeld-Germany/Datapage&printable=yes
DeCSDeCS
Alanine Racemase - Preferred Concept UI. M0000622. Scope note. A pyridoxal-phosphate protein that reversibly catalyzes the ... A pyridoxal-phosphate protein that reversibly catalyzes the conversion of L-alanine to D-alanine. EC 5.1.1.1.. ...
https://decs.bvsalud.org/en/ths/resource/?id=414
Code System Concept
Alanine racemase (substance). Code System Preferred Concept Name. Alanine racemase (substance). Concept Status. Published. ...
https://phinvads.cdc.gov/vads/ViewCodeSystemConcept.action?oid=2.16.840.1.113883.6.96&code=9582000
Andres SAndres S
Role of alanine racemase mutations in Mycobacterium tuberculosis D-cycloserine resistance *Autores: Andres S, Aung HL, Beckert ... of Mycobacterium tuberculosis revealed evolutionary patterns characteristic of positive selection for three alanine racemase ( ...
https://ghtm.ihmt.unl.pt/authors/andres-s/
HOMD :: SEQF1173HOMD :: SEQF1173
Alanine racemase. 23. SEQF1173,CP002468.1. SEQF1173_00023 jb [NA] [AA] 462/153. 25593-26054. hypothetical protein. ... D-alanyl-D-alanine carboxypeptidase DacC. 104. SEQF1173,CP002468.1. SEQF1173_00106 jb [NA] [AA] 978/325. 126806-125829. Aldose ...
https://ehomd.org/genome/explorer?gid=SEQF1173&anno=prokka
B6db sequences : edt66487
Alanine racemase. Activity. 5.1.1.1. Family. 5.1.1.1.a. Evidence. IDA - direct assay. ...
http://bioinformatics.unipr.it/cgi-bin/bioinformatics/B6db/seq.pl/Show?edt66487
Thermus thermophilus HB8 Whole Cell Project Database -Target List
alanine racemase. 1:complement(58555..59637). First , Prev , Records1 - 50 / 8255 , Next , Last. ...
http://www.tanpaku.org/ThermusDB/fmi/xsl/InfoCenter3/recordlist.xsl?-lay=IC3_WebList2&-max=50&-findall
English-Armenian Medical - Terms starting with 'L' - MEDINDEX.AM
4. ALANINE AMINOTRANSFERASE [ԱԼԱՆԻՆՆԱՄԻՆՈՏՐԱՆՍՖԵՐԱԶԱ] 54. ALGAE, GREEN [ՋՐԻՄՈՒՌՆԵՐ ԿԱՆԱՉ] 5. ALANINE RACEMASE [ԱԼԱՆԻՆՌԱՑԵՄԱԶԱ] ...
https://www.medindex.am/glossary/index.php/list/English-Armenian+Medical/,A,L,.xhtml
"sequence id","alias","species","description",...
Alanine racemase [Interproscan].","protein_coding" "AAC76001","nupG","Escherichia coli","nucleoside transporter [Ensembl]. ... ","1,6-anhydro-N-acetylmuramyl-L-alanine amidase, Zn-dependent; murein amidase [Ensembl]. N-acetylmuramoyl-L-alanine amidase [ ... ","D-alanyl-D-alanine endopeptidase [Ensembl]. D-alanyl-D-alanine carboxypeptidase [Interproscan].","protein_coding" "AAC75204 ... D-alanyl-D-alanine carboxypeptidase [Interproscan].","protein_coding" "CCL18922","argH","Clostridioides difficile"," ...
https://bacteria.sbs.ntu.edu.sg/go/sequences/table/7015
Nucleoid (470)
Alanine racemase (EC 5.1.1.1). cytoplasmic. A. 3MGH_STRCO. Q9S208. SCO1792 SCI51.32c ...
http://stopsdb.eu/scoel_toplist.php?start=21
Network Portal - Gene BC2583
Alanine racemase (NCBI ptt file). 10, 223. BC2189. BC2189. Aminoglycoside phosphotransferase (NCBI ptt file). 209, 407. ... D-alanyl-D-alanine carboxypeptidase (NCBI ptt file). 163, 209. BC3265. BC3265. hypothetical Cytosolic Protein (NCBI ptt file). ...
http://networks.systemsbiology.net/bce/gene/BC2583
NWMN RS07380 - AureoWikiNWMN RS07380 - AureoWiki
TIM_barrel (CL0036) Ala_racemase_N; Alanine racemase, N-terminal domain (PF01168; HMM-score: 21.1) ...
https://aureowiki.med.uni-greifswald.de/NWMN_RS07380
Pesquisa | Portal Regional da BVSPesquisa | Portal Regional da BVS
... maritima has neither alanine racemase nor glutamate racemase enzymes; hence, the precise biosynthetic pathways of d-alanine and ... We previously identified a lysine racemase involved in d-lysine biosynthesis, and this enzyme also possesses alanine racemase ... Alanina Racemase , Aminoácidos , Alanina/genética , Alanina/metabolismo , Alanina Racemase/metabolismo , Aminoácidos/ ... TM0831 is a novel d-amino acid aminotransferase with racemase activity that is involved in the production of d-amino acids in T ...
https://pesquisa.bvsalud.org/portal/?lang=pt&q=mh:%C3%81cido+Asp%C3%A1rtico/gen%C3%A9tica
DeCS 2017 - December 21, 2017 versionDeCS 2017 - December 21, 2017 version
Racemase, Alanine use Alanine Racemase Racemases use Racemases and Epimerases Racemases and Epimerases ...
https://decs.bvs.br/I/DeCS2017_Alfab-R.htm
Cycloserine: Uses, Interactions, Mechanism of Action | DrugBank OnlineCycloserine: Uses, Interactions, Mechanism of Action | DrugBank Online
L-alanine racemase, which forms D-alanine from L-alanine, and D-alanylalanine synthetase, which incorporates D-alanine into the ... Catalyzes the interconversion of L-alanine and D-alanine.. Gene Name. alr. Uniprot ID. Q9L888. Uniprot Name. Alanine racemase. ... Feng Z, Barletta RG: Roles of Mycobacterium smegmatis D-alanine:D-alanine ligase and D-alanine racemase in the mechanisms of ... Gene cloning, characterization, and kinetics of its alanine racemase and D-alanyl-D-alanine ligase, which are target enzymes of ...
https://go.drugbank.com/drugs/DB00260
Serine racemaseLigaseEnzymesMycobacteriumCarboxypeptidaseEnzymeAmino acidGlutamateProteinReactionBiosynthesisAmidaseInhibitsGenePeptidoglycanStructuralCatalyzesGenesStrainSimilarFindProline racemaseHistidine racemaseBacillusPseudomonasCompoundsArgininePathwayOenococcusNitrogen sourceCharacterizationBacteriaBurkholderiaSubstrateStructuresResiduesSpeciesEssentialActivityFoldStructureSignificant
Serine racemase4
  • RESULTS The vanGCar locus contained four genes encoding a carboxypeptidase, a d-alanine:d-serine ligase, a serine transporter and a serine racemase, and was present in the seven C. argentinense studied. (archives-ouvertes.fr)
  • A similar enzyme is serine racemase (EC 2.6.1.3). (matteoferla.com)
  • There are two types of serine racemase, the eukaryotic and archaeal one, srr encoded, and a bacterial one, vanT encoded. (matteoferla.com)
  • This study investigated N-methyl-D-aspartate receptor (NMDAR) antagonist interactions with serine racemase (SR) to obtain potential chronic pain target therapy. (d-aminoacids.com)
Ligase5
  • D-cylcoserine phosphate in complex with ADP and magnesium bound at the active site of E. coli D-ala-D-alanine ligase. (infectioncontroltoday.com)
  • The drug attacks bacteria by inhibiting two separate enzymes (D-alanine racemase and D-alanine--D-alanine ligase) each required to build and maintain the structural integrity of bacterial cell walls. (infectioncontroltoday.com)
  • The researchers have observed, for the first time, how D-cycloserine inhibits the D-alanine-D-alanine ligase enzyme. (infectioncontroltoday.com)
  • David Roper, who is professor of biochemistry and structural biology at the University Warwick, commented, 'In this new discovery, we see that D-cycloserine binds to the D-alanine-D-alanine ligase enzyme and becomes chemically modified on the enzyme. (infectioncontroltoday.com)
  • In this new discovery, we see that D-cycloserine binds to the D-alanine-D-alanine ligase enzyme and becomes chemically modified on the enzyme . (medicalxpress.com)
Enzymes4
  • Alanine racemase (AlaR) is a bacterial enzyme that belongs to the fold-type III group of pyridoxal 5′-phosphate (PLP)-dependent enzymes. (elsevier.com)
  • It interferes with an early step in bacterial cell wall synthesis in the cytoplasm by competitive inhibition of two enzymes, L-alanine racemase, which forms D-alanine from L-alanine, and D-alanylalanine synthetase, which incorporates D-alanine into the pentapeptide necessary for peptidoglycan formation and bacterial cell wall synthesis. (drugbank.com)
  • These proteins are fold type III PLP-dependent enzymes that contain an N-terminal PLP-binding TIM-barrel domain and a C-terminal beta-sandwich domain, similar to bacterial alanine racemases, eukaryotic ornithine decarboxylases and diaminopimelate decarboxylases. (umbc.edu)
  • These enzymes catalyze the transfer of a particular group from one substrate to another e.g., aspartate amino transferase (AST), alanine aminotransferase (ALT), hexokinase, phosphoglucomutase, hexose- 1-phosphate uridyltransferase, ornithine carbamoyl transferase etc. (amano-enzyme.com)
Mycobacterium2
  • Mycobacterium smegmatis alr insertion mutants are not dependent on d -alanine for growth and display a metabolic pattern consistent with an alternative pathway for d -alanine biosynthesis. (microbiologyresearch.org)
  • A screening of more than 1,500 drug-resistant strains of Mycobacterium tuberculosis revealed evolutionary patterns characteristic of positive selection for three alanine racemase (Alr) mutations. (unl.pt)
Carboxypeptidase1
  • Penicillin-binding protein 5, D-alanyl-D-alanine carboxypeptidase [Interproscan]. (ntu.edu.sg)
Enzyme9
  • The enzyme was therefore designated Ala/Ser racemase (ASR). (tokushima-u.ac.jp)
  • With the D-alanine racemase enzyme, it is known that the drug forms a molecular bond with a chemical group required for the enzyme activity, stopping it from working. (infectioncontroltoday.com)
  • An alanine racemase is a catalyzing enzyme for a chemical process. (lambdageeks.com)
  • This enzyme is a member of the isomerase family, particularly racemases and epimerases that operate on amino acids and other derivatives. (lambdageeks.com)
  • Cysteine racemase: an impossible enzyme? (matteoferla.com)
  • Cysteine racemase is an enzyme (EC 5.1.1.10) that was characterised in lysates long ago, but have never been found since. (matteoferla.com)
  • The alanine racemase inhibitor β-chloroalanine works thanks to the fact that the enzyme tries to racemise it, but instead quickly eliminates it and the PLP π-stacking tyrosine (eventually) gets alkylated (=electrophilic aromatic substitution). (matteoferla.com)
  • Broad spectrum racemases, such as the one encoded by bsrV in Vibrio , also can racemise cysteine and this is the strongest proof that the enzyme activity is actually possible. (matteoferla.com)
  • In fact, the origins of the word "Enzyme" derive from Greek: "en" (in) and "zyme" (ferment). (amano-enzyme.com)
Amino acid4
  • We recently identified and characterized a novel broad substrate specificity amino acid racemase (BAR) from the hyperthermophilic archaeon Pyrococcus horikoshii OT-3. (tokushima-u.ac.jp)
  • In this study, we detected pyridoxal 5'-phosphate (PLP)-dependent amino acid racemase activity in the protein encoded by PH0782. (tokushima-u.ac.jp)
  • Cycloserine is an analog of the amino acid D-alanine. (drugbank.com)
  • It is an analogue of D-alanine amino acid. (pharmasyntez.com)
Glutamate2
  • X-ray diffraction data for the Crystal structure of glutamate racemase from Francisella tularensis subsp. (proteindiffraction.org)
  • In this reaction the amino group from alanine is transferred to α -ketoglutarate to form glutamate. (brainkart.com)
Protein2
  • Biosafety System taking advantage of the alanine racemase and the tight repression of the arabinose promoter P araBAD by the AraC protein. (igem.org)
  • A pyridoxal-phosphate protein that reversibly catalyzes the conversion of L-alanine to D-alanine. (bvsalud.org)
Reaction3
  • The traditional mechanism attributed to an alanine racemase reaction is that of a two-base mechanism with a PLP-stabilized carbanion intermediate. (ichacha.net)
  • The primary route of d -alanine biosynthesis in eubacteria is the enantiomeric conversion from l -alanine, a reaction catalysed by d -alanine racemase (Alr). (microbiologyresearch.org)
  • No enzymatic steps are represented because L-alanine is a single transamination reaction away from pyruvate, which is a central metabolic intermediate. (lbl.gov)
Biosynthesis1
  • AlaR catalyzes the interconversion between l- and d-alanine, which is important for peptidoglycan biosynthesis. (elsevier.com)
Amidase2
  • N-acetylmuramoyl-L-alanine amidase [Interproscan]. (ntu.edu.sg)
  • X-ray diffraction data for the 2.15 Angstrom Crystal Structure of N-acetylmuramoyl-L-alanine Amidase from Staphylococcus aureus. (proteindiffraction.org)
Inhibits1
  • It competitively inhibits activity of alanine racemase converting L-alanine into D-alanine and D-alanine syntase which incorporates D-alanine into the pentapeptide necessary for peptidoglycan formation and bacterial cell wall synthesis. (pharmasyntez.com)
Gene2
  • Bacteria can have one ( alr gene ) or two alanine racemase genes. (ichacha.net)
  • The nucleotide sequence of the alanine racemase (EC 5.1.1.1) gene from a thermophile, Bacillus stearothermophilus, was determined by the dideoxy chain termination method with universal and synthetic site-specific primers. (elsevier.com)
Peptidoglycan2
  • d -Alanine is a structural component of mycobacterial peptidoglycan. (microbiologyresearch.org)
  • Peptidoglycan precursors may contain D-lactate as the C-terminal D-alanine residue of the muramyl pentapeptide is replaced by D-lactate, known as a pentadepsipeptide. (biomedcentral.com)
Structural1
  • Our results provide structural insights into AlaR that may be used for the development of new antibiotics targeting the alanine racemase in pathogenic bacteria. (elsevier.com)
Catalyzes1
  • Catalyzes the reversible isomerization from L-alanine into the enatiomer D-alanine. (igem.org)
Genes1
  • Bacterial species with two genes for alanine racemase have one that is continually expressed and one that is inducible, which makes it difficult to target both genes for drug studies. (ichacha.net)
Strain2
  • In this study, we demonstrate that the M. smegmatis alr insertion mutant TAM23 can synthesize d -alanine at lower levels than the parental strain. (microbiologyresearch.org)
  • In an D-alanine auxotrophic strain it can be used as a antibiotic free selection marker. (igem.org)
Similar1
  • Although the residues common inthe four racemases are not continuously arrayed, these constitute distinct domains and theirhydropathy profiles are very similar. (elsevier.com)
Find1
  • It's difficult to find alanine racemase in a sentence. (ichacha.net)
Proline racemase1
  • In pathway II, proline racemase (prdF) forms D-proline, and a reductase forms 5-aminovalerate. (lbl.gov)
Histidine racemase2
  • The first identification and characterization of a histidine-specific amino acid racemase, histidine racemase from a lactic acid bacterium, Leuconostoc mesenteroides subsp. (unipr.it)
  • We expressed a histidine racemase from Leuconostoc mesenteroides subsp. (unipr.it)
Bacillus1
  • The domain makeup of each monomer is similar to that of Bacillus and Pseudomonas alanine racemases and includes both an alpha/beta-barrel at the N-terminus and a C-terminus primarily made of beta-strands. (nih.gov)
Pseudomonas1
  • Arginine racemase of Pseudomonas graveolens. (unipr.it)
Compounds1
  • Chemical derivatization of the lead resulted in compounds NR-1213 AND NR-1124 as the potent M. tuberculosis glutamate racemase inhibitors with IC50 of 4-5µM which are remarkable and were found to be non-cytotoxic. (waset.org)
Arginine1
  • Can also use arginine and ornithine, but not alanine. (uniprot.org)
Pathway1
  • This indicates that S. pombe has catabolic pathways for both enantiomers of alanine and that the pathway for L-alanine coupled with racemization plays a major role in the catabolism of D-alanine. (omicsdi.org)
Oenococcus1
  • When comparing the 3D structure of Lm-HisR with those of racemases from Geobacillus stearothermophilus and Oenococcus oeni, Met315 was completely conserved, but Val357 was not. (unipr.it)
Nitrogen source1
  • Saccharomyces cerevisiae differs markedly from S. pombe: S. cerevisiae uses L-alanine but not D-alanine as a sole nitrogen source. (omicsdi.org)
Characterization1
  • Functional characterization of alanine racemase from Schizosaccharomyces pombe: a eucaryotic counterpart to bacterial alanine racemase. (omicsdi.org)
Bacteria2
  • Comparison of AlrAba with alanine racemases from closely related bacteria demonstrates a conserved overall fold. (omicsdi.org)
  • Phylogenetic analysis of Lm-HisR showed that Lm-HisR was located far from the cluster of alanine racemases reported thus far and only in lactic acid bacteria of the genus Leuconostoc. (unipr.it)
Burkholderia1
  • Alanine racemase mutants of Burkholderia pseudomallei and Burkholderia mallei and use of alanine racemase as a non-antibiotic-based selectable marker. (ucdenver.edu)
Substrate1
  • Based on the structural analysis, comparison with alanine racemase, and docking simulation, three significant residues, Phe44, His286, and Val357, were identified that may control the substrate specificity of Lm-HisR. (unipr.it)
Structures1
  • Also, as observed in other alanine racemase structures, PLP adopts a conformation that significantly distorts the planarity of the extended conjugated system between the PLP ring and the internal aldimine bond. (nih.gov)
Residues1
  • Analysis of the active site pocket, in the context of other known alanine racemases, allows us to propose the inclusion of conserved residues found at the entrance to the binding pocket as additional targets in ongoing structure-aided drug design efforts. (nih.gov)
Species1
  • Binding of both alanine enantiomers leads to the appearance of an external aldimine absorbing at 429 nm and of a band absorbing at 498 nm, indicative of a quinonoid species. (omicsdi.org)
Essential1
  • As D-alanine is an essential component of the bacterial cell wall, its inhibition is lethal to prokaryotes, making it an excellent antibiotic drug target. (omicsdi.org)
Activity3
  • Treponema denticola cystalysin exhibits significant alanine racemase activity accompanied by transamination: mechanistic implications. (omicsdi.org)
  • During the reaction of cystalysin with L- or D-alanine, a time-dependent loss of beta-elimination activity occurs concomitantly with the conversion of the pyridoxal 5'-phosphate (PLP) coenzyme into pyridoxamine 5'-phosphate (PMP). (omicsdi.org)
  • Lm-HisR showed amino acid racemase activity on histidine specifically. (unipr.it)
Fold1
  • The catalytic efficiency of the half-transamination of L-alanine is found to be 5.3x10(-5) mM(-1) x s(-1), 5-fold higher when compared with that of D-alanine. (omicsdi.org)
Structure1
  • The structure of alanine racemase from Acinetobacter baumannii. (omicsdi.org)
Significant1
  • In addition, two significant differences were observed between Lm-HisR and G. stearothermophilus alanine racemase. (unipr.it)