An NAD-dependent enzyme that catalyzes the reversible DEAMINATION of L-ALANINE to PYRUVATE and AMMONIA. The enzyme is needed for growth when ALANINE is the sole CARBON or NITROGEN source. It may also play a role in CELL WALL synthesis because L-ALANINE is an important constituent of the PEPTIDOGLYCAN layer.
A class of enzymes that catalyze oxidation-reduction reactions of amino acids.
A pyridoxal-phosphate protein that reversibly catalyzes the conversion of L-alanine to D-alanine. EC 5.1.1.1.
A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM.
An oxidoreductase that catalyzes the oxidative DEAMINATION of GLYCINE to glyoxylate and AMMONIA in the presence of NAD. In BACTERIA lacking transaminating pathways the enzyme can act in the reverse direction to synthesize glycine from glyoxylate and ammonia and NADH.
A colorless alkaline gas. It is formed in the body during decomposition of organic materials during a large number of metabolically important reactions. Note that the aqueous form of ammonia is referred to as AMMONIUM HYDROXIDE.
A coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)
The rate dynamics in chemical or physical systems.
A characteristic feature of enzyme activity in relation to the kind of substrate on which the enzyme or catalytic molecule reacts.

Cold-adapted alanine dehydrogenases from two antarctic bacterial strains: gene cloning, protein characterization, and comparison with mesophilic and thermophilic counterparts. (1/60)

The genes encoding NAD(+)-dependent alanine dehydrogenases (AlaDHs) (EC 1.4.1.1) from the Antarctic bacterial organisms Shewanella sp. strain Ac10 (SheAlaDH) and Carnobacterium sp. strain St2 (CarAlaDH) were cloned and expressed in Escherichia coli. Of all of the AlaDHs that have been sequenced, SheAlaDH exhibited the highest level of sequence similarity to the AlaDH from the gram-negative bacterium Vibrio proteolyticus (VprAlaDH). CarAlaDH was most similar to AlaDHs from mesophilic and thermophilic Bacillus strains. SheAlaDH and CarAlaDH had features typical of cold-adapted enzymes; both the optimal temperature for catalytic activity and the temperature limit for retaining thermostability were lower than the values obtained for the mesophilic counterparts. The k(cat)/K(m) value for the SheAlaDH reaction was about three times higher than the k(cat)/K(m) value for VprAlaDH, but it was much lower than the k(cat)/K(m) value for the AlaDH from Bacillus subtilis. Homology-based structural models of various AlaDHs, including the two psychotropic AlaDHs, were constructed. The thermal instability of SheAlaDH and CarAlaDH may result from relatively low numbers of salt bridges in these proteins.  (+info)

Properties of the 40 kDa antigen of Mycobacterium tuberculosis, a functional L-alanine dehydrogenase. (2/60)

The 40 kDa antigen of Mycobacterium tuberculosis is the first antigen reported to be present in the pathogenic M. tuberculosis, but not in the vaccine strain Mycobacterium bovis BCG. It is a functional L-alanine dehydrogenase (EC 1.4.1.1) and hence one of the few antigens possessing an enzymic activity. This makes the 40 kDa antigen attractive for potential diagnostic and therapeutic interventions. Recently, we developed a strategy to purify quantities of the recombinant protein in active form, and here we describe the biochemical properties of this enzyme. In the oxidative-deamination reaction, the enzyme showed K(m) values of 13. 8 mM and 0.31 mM for L-alanine and NAD(+), respectively, in a random-ordered mechanism. K(m, app) values in the reductive-amination reaction are 35.4 mM, 1.45 mM and 98.2 microM for ammonium, pyruvate and NADH, respectively. The enzyme is highly specific for all of its substrates in both directions. The pH profile indicates that oxidative deamination virtually may not occur at physiological pH. Hence L-alanine most likely is the product of the reaction catalysed in vivo. The enzyme is heat-stable, losing practically no activity at 60 degrees C for several hours.  (+info)

Structure and mechanism of proton-translocating transhydrogenase. (3/60)

Recent developments have led to advances in our understanding of the structure and mechanism of action of proton-translocating (or AB) transhydrogenase. There is (a) a high-resolution crystal structure, and an NMR structure, of the NADP(H)-binding component (dIII), (b) a homology-based model of the NAD(H)-binding component (dI) and (c) an emerging consensus on the position of the transmembrane helices (in dII). The crystal structure of dIII, in particular, provides new insights into the mechanism by which the energy released in proton translocation across the membrane is coupled to changes in the binding affinities of NADP(+) and NADPH that drive the chemical reaction.  (+info)

Disruption of aldA influences the developmental process in Myxococcus xanthus. (4/60)

Previously, we identified a gene (aldA) from Myxococcus xanthus, which we suggested encoded the enzyme alanine dehydrogenase on the basis of similarity to known Ald protein sequences (M. J. Ward, H. Lew, A. Treuner-Lange, and D. R. Zusman, J. Bacteriol. 180:5668-5675, 1998). In this study, we have confirmed that aldA does encode a functional alanine dehydrogenase, since it catalyzes the reversible conversion of alanine to pyruvate and ammonia. Whereas an aldA gene disruption mutation did not significantly influence the rate of growth or spreading on a rich medium, AldA was required for growth on a minimal medium containing L-alanine as the major source of carbon. Under developmental conditions, the aldA mutation caused delayed aggregation in both wild-type (DZ2) and FB (DZF1) strains. Poorly formed aggregates and reduced levels of spores were apparent in the DZ2 aldA mutant, even after prolonged development.  (+info)

Protein-coding genes as molecular markers for ecologically distinct populations: the case of two Bacillus species. (5/60)

Bacillus globisporus and Bacillus psychrophilus are one among many pairs of ecologically distinct taxa that are distinguished by very few nucleotide differences in 16S rRNA gene sequence. This study has investigated whether the lack of divergence in 16S rRNA between such species stems from the unusually slow rate of evolution of this molecule, or whether other factors might be preventing neutral sequence divergence at 16S rRNA as well as every other gene. B. globisporus and B. psychrophilus were each surveyed for restriction-site variation in two protein-coding genes. These species were easily distinguished as separate DNA sequence clusters for each gene. The limited ability of 16S rRNA to distinguish these species is therefore a consequence of the extremely slow rate of 16S rRNA evolution. The present results, and previous results involving two Mycobacterium species, demonstrate that there exist closely related species which have diverged long enough to have formed clearly separate sequence clusters for protein-coding genes, but not for 16S rRNA. These results support an earlier argument that sequence clustering in protein-coding genes could be a primary criterion for discovering and identifying ecologically distinct groups, and classifying them as separate species.  (+info)

Reassessment of major products of N2 fixation by bacteroids from soybean root nodules. (6/60)

NH3/ was the principal product from soybean bacteroids, prepared by various procedures, when assayed in solution in a flow chamber under N2 fixation conditions. In addition, small quantities of alanine were produced (reaching 20% of NH3/ under some conditions). Some 15N was assimilated by bacteroids purified from soybean root nodules on Percoll density gradients and shaken with 15N2 and 0.008 atm O2. Under these conditions, accounted for 93% of the (15)N fixed into the soluble fraction. This fraction contained no measurable [15N]alanine. Neither these bacteroids nor those prepared by the previously used differential centrifugation method, when incubated with exogenous alanine under non-N2-fixing conditions, gave rise to NH3 from alanine. Therefore, contamination of bacteroid preparations with enzymes of plant cytosolic origin and capable of producing NH3 from alanine cannot explain the failure to detect [15N]alanine [as reported elsewhere: Waters, J. K., Hughes, B. L., II, Purcell, L. C., Gerhardt, K. O., Mawhinney, T. P. & Emerich, D. W. (1998). Proc Natl Acad Sci USA 95, 12038-12042]. Cell-free extracts of the bacteroids as used in the 15N experiments contained alanine dehydrogenase and were able to produce alanine from pyruvate and. Other experiments with alanine dehydrogenase in extracts of cultured rhizobia and bacteroids are reported and discussed in relation to the 15N experiments. Possible reasons for the differences between laboratories regarding the role of alanine are discussed. It is concluded that NH3 is the principal soluble product of N2 fixation by suspensions of soybean bacteroids ex planta and that should continue to be considered the principal product of N2 fixation which is assimilated in vivo in soybean nodules.  (+info)

Hypoxic response of Mycobacterium tuberculosis studied by metabolic labeling and proteome analysis of cellular and extracellular proteins. (7/60)

The events involved in the establishment of a latent infection with Mycobacterium tuberculosis are not fully understood, but hypoxic conditions are generally believed to be the environment encountered by the pathogen in the central part of the granuloma. The present study was undertaken to provide insight into M. tuberculosis protein expression in in vitro latency models where oxygen is depleted. The response of M. tuberculosis to low-oxygen conditions was investigated in both cellular and extracellular proteins by metabolic labeling, two-dimensional electrophoresis, and protein signature peptide analysis by liquid chromatography-mass spectrometry. By peptide mass fingerprinting and immunodetection, five proteins more abundant under low-oxygen conditions were identified from several lysates of M. tuberculosis: Rv0569, Rv2031c (HspX), Rv2623, Rv2626c, and Rv3841 (BfrB). In M. tuberculosis culture filtrates, two additional proteins, Rv0363c (Fba) and Rv2780 (Ald), were found in increased amounts under oxygen limitation. These results extend our understanding of the hypoxic response in M. tuberculosis and potentially provide important insights into the physiology of the latent bacilli.  (+info)

Mycobacterium smegmatis L-alanine dehydrogenase (Ald) is required for proficient utilization of alanine as a sole nitrogen source and sustained anaerobic growth. (8/60)

NAD(H)-dependent L-alanine dehydrogenase (EC 1.4.1.1) (Ald) catalyzes the oxidative deamination of L-alanine and the reductive amination of pyruvate. To assess the physiological role of Ald in Mycobacterium smegmatis, we cloned the ald gene, identified its promoter, determined the protein expression levels, and analyzed the combined effects of nutrient supplementation, oxygen availability, and growth stage on enzyme activity. High Ald activities were observed in cells grown in the presence of L- or D-alanine regardless of the oxygen availability and growth stage. In exponentially growing cells under aerobic conditions, supplementation with alanine resulted in a 25- to 50-fold increase in the enzyme activity. In the absence of alanine supplementation, 23-fold-higher Ald activities were observed in cells grown exponentially under anaerobic conditions. Furthermore, M. smegmatis ald null mutants were constructed by targeted disruption and were shown to lack any detectable Ald activity. In contrast, the glycine dehydrogenase (EC 1.4.1.10) (Gdh) activity in mutant cells remained at wild-type levels, indicating that another enzyme protein is responsible for the physiologically relevant reductive amination of glyoxylate. The ald mutants grew poorly in minimal medium with L-alanine as the sole nitrogen source, reaching a saturation density 100-fold less than that of the wild-type strain. Likewise, mutants grew to a saturation density 10-fold less than that of the wild-type strain under anaerobic conditions. In summary, the phenotypes displayed by the M. smegmatis ald mutants suggest that Ald plays an important role in both alanine utilization and anaerobic growth.  (+info)

TY - JOUR. T1 - Mycobacterium smegmatis L-alanine dehydrogenase (Ald) is required for proficient utilization of alanine as a sole nitrogen source and sustained anaerobic growth. AU - Feng, Zhengyu. AU - Cáceres, Nancy E.. AU - Sarath, Gautam. AU - Barletta, Raúl G.. PY - 2002/9. Y1 - 2002/9. N2 - NAD(H)-dependent L-alanine dehydrogenase (EC 1.4.1.1) (Aid) catalyzes the oxidative deamination of L-alanine and the reductive amination of pyruvate. To assess the physiological role of Aid in Mycobacterium smegmatis, we cloned the ald gene, identified its promoter, determined the protein expression levels, and analyzed the combined effects of nutrient supplementation, oxygen availability, and growth stage on enzyme activity. High Ald activities were observed in cells grown in the presence of L- or D-alanine regardless of the oxygen availability and growth stage. In exponentially growing cells under aerobic conditions, supplementation with alanine resulted in a 25- to 50-fold increase in the enzyme ...
TY - JOUR. T1 - Identification and Purification of an L-Alanine Dehydrogenase Homolog that Catalyzes the Formation of L-Ornithine Lactam from Streptomyces incarnatus Sinefungin-Producing NRRL8089. AU - Inagaki, Kenji. PY - 2010. Y1 - 2010. M3 - Article. VL - 24. SP - 63. EP - 65. JO - Actinomycetologica. JF - Actinomycetologica. IS - 2. ER - ...
Alanine dehydrogenase catalyses the NAD-dependent reversible reductive amination of pyruvate into alanine. Pyridine nucleotide transhydrogenase catalyses the reduction of NADP+ to NADPH with the concomitant oxidation of NADH to NAD+. This enzyme is located in the plasma membrane of prokaryotes and in the inner membrane of the mitochondria of eukaryotes. The transhydrogenation between NADH and NADP is coupled with the translocation of a proton across the membrane. In prokaryotes the enzyme is composed of two different subunits, an alpha chain (gene pntA) and a beta chain (gene pntB), while in eukaryotes it is a single chain protein.. The sequence of alanine dehydrogenase from several bacterial species is related with that of the alpha subunit of bacterial pyridine nucleotide transhydrogenase and the N-terminal half of the eukaryotic enzyme. The two most conserved regions correspond respectively to the N-terminal domain of these proteins, and to a central glycine-rich region which is part of the ...
1OMO: Structure of alanine dehydrogenase from Archaeoglobus: active site analysis and relation to bacterial cyclodeaminases and mammalian mu crystallin.
1OMO: Structure of alanine dehydrogenase from Archaeoglobus: active site analysis and relation to bacterial cyclodeaminases and mammalian mu crystallin.
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Adherencia al tratamiento en enfermedad cardiovascular: rediseño y validación de un instrumento / Adherence to treatment in cardiovascular disease: Re-design and validation of an instrument / Aderência ao tratamento em doença cardiovascular: Redesenho e validação de um instrumento
The primers used to make this knockout were AACAATGTATTCACCGAAAACAAACATATAAATCACAGGAGTCGCCCATGATTCCGGGGATCCGTCGACC and GAGGAAAAAACCTCCGCCTCTTTCACTCATTAAGACTGTAAATAAACCACTGTAGGCTGGAGCTGCTTCG the bolded sequence matches the pKD13 ...
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An NAD-dependent enzyme that catalyzes the reversible Deamination of L-Alanine to PYRUVATE and Ammonia. The enzyme is needed for Growth when Alanine is the sole Carbon or Nitrogen source. It may also play a Role in Cell Wall synthesis because L-Alanine is an important constituent of the PEPTIDOGLYCAN layer ...
Marius Ader is the author of this article in the Journal of Visualized Experiments: Subretinal Transplantation of MACS Purified Photoreceptor Precursor Cells into the Adult Mouse Retina
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Resumo: Apresenta-se, neste trabalho, o estudo desenvolvido sobre o fenômeno da aderência em Concretos de Alto Desempenho, através de ensaios à flexão de vigas de concreto armado com CAD. A aderência foi analisada sob os aspectos de ancoragem e fissuração na região das barras longitudinais emendadas por transpasse. Os modelos das vigas ensaiadas foram de três tipos, conforme a maneira em que as barras foram transpassadas. Para cada modelo, foram avaliados os parâmetros de: resistência do concreto, diâmetro das barras, comprimento de emenda, cobrimentos das barras e o comportamento das variadas emendas. Os resultados foram, ainda, analisados com as equações internacionais para predição da aderência e com a NBR 6118: ...
Alda returned to Broadway in November 2014, playing the role of Andrew Makepeace in the revival of at the alongside. Share Generally, there are five stages to Parkinsons.
The company is now developing a diagnostic kit for prostate cancer with the aptamer immuno-PCR, enabling to detect and quantify three different target proteins at the same time in one tube including PSA. Preliminary studies have shown that the simultaneous detection of multiple proteins is possible with this technology. Importantly, the test with the aptamer immuno-PCR has shown that the detection of PSA is 1,000 times more sensitive than ELISA. Additionally, one of the advantages of the method is that both urine samples and serum samples can be used for the diagnosis of prostate cancer for easy collection of clinical samples and convenient use in clinical laboratories ...
Resumo: Com vistas ao uso crescente de materiais reciclados provenientes da construção civil, principalmente como substituição de parte dos agregados em misturas de concreto, torna-se necessário suprir o meio técnico com informações sobre o desempenho destas novas mistura. Então, este trabalho avaliou o desempenho do concreto com agregado graúdo de resíduo de cerâmica vermelha para fins estruturais. Para tanto, foram produzidas quatro misturas de concreto; uma de referência, sem qualquer substituição, e outras três misturas com substituição gradual do agregado graúdo por um agregado de resíduos de cerâmica vermelha (20%, 40% e 100% de substituição, em volume). Uma primeira etapa avaliou a tensão de aderência entre barras de aço e concreto. Os resultados obtidos, com relação à tensão de aderência entre barra de aço e concreto, indicaram a viabilidade de emprego do resíduo de cerâmica vermelha como substituição de parte do agregado graúdo na produção de ...
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All content on this website is for informational purposes only and should not be considered to be a specific diagnosis or treatment plan for any individual situation. Use of this website and the information contained herein does not create a doctor-patient relationship. Always consult with your own doctor in connection with any questions or issues you may have regarding your own health or the health of others ...
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Alan Alda chats with Seth about the keys to communication from his book If I Understood You, Would I Have This Look On My Face? and explains why you shouldnt perform gibberish shows for drunken sailors. ...
Two experts from the Alan Alda Center for Communicating Science explain why formulating and delivering a message is not enough, regardless of the audience.
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L-Alanine (C3 H7 NO2) is a non-essential amino acid which may be considered essential under some circumstances. L-Alanine is highly concentrated in muscle tissue. Excess L-Alanine may be broken down into glucose and used as an energy source. L-Alanine can also function as an inhibitory or calming neurotransmitter in th
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The M*A*S*H star told CBS This Morning Tuesday that he was diagnosis with the disease three and a half years ago but has managed to live a full life since then.
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Per sostanze con un l-o un prefisso L-come L-alanine o DL-alanine, per favore, vedi la pagina di genitori (in questo caso alanine).. ...
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AuxInfo=1/1/N:4,2,3,1,5,6/E:(5,6)/it:im/rA:6nN+CCCOO-/rB:s1;s2;P2;d3;s3;/rC:-1.0717,-.2062,0;-.3572,.2062,0;.3572,-.2062,0;-.3572,1.0312,0;.3572,-1.0312,0;1.0717,.2062,0 ...
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minggu lepas aku rasa cam sedih sket kat dunia K-POP . 2PM leader JaeBom keluar group sbb preassure dr netizen buat aku pun rase tension. bukan aku minat pun ngan 2PM tp budak tuh bukan nyer buat kesalahan bunuh org ker merompak ker sampai netizen suruh dia gi bunuh diri. Lagi satu pasal group kesayangan aku 2NE1 pun asyik kena target jer kat blog2 yg jeles ngan dia org ni. yerla memang ler dia org ni takder cantik mcm budak2 SNSD yg plastic tu tp kureng2 nye dia org ader style & talented, nak buat camne kan org talent memang ler selalu menang award. Yg penting jangan ader group member 2NE1 yg tension dan keluar dr group udah ...
ok, otak kiter pun ader switch off button....dipanggil reticular activating system RAS.......bila otak dah switch off badan, dia pun auto switch off RAS ni......so tinggal automatic function (degupan jantung, bernafas etc.) jer yang on.....kirenyer screensaver laaa or hibernate... so,, bila kita bangun, RAS switched on balik......kita sedar fully awake state....tapi kadang2, electrical signal tak diactivate kan oleh otak suh switch on balik badan kiter...... maka masa tu laa badan kita lumpuh seketika... before otak activate balik......mmg menakutkan tapi benar..... tapi paralysis tu tak semestinyer complete atau full..kadang2 partial atau sebahagian jer...tu ader yang boleh gerakkan ibu jari, tp badan lain lumpuh etc ...
Morning sickness might occur due to hormonal changes or stretching and distension of the uterus. Dam may appear a bit apathetic. She may be off her feed for a while and vomit from time to time. Feeding the dam several meals spaced throughout the day might help. Your veterinarian may want to prescribe a drug to relax the uterus. Alda is now very mellow and sleepy. Her response to seeing the Vet for the ultrasound was quiet and unexcited (not her usual self). She is eating well and seems hungry.. ...
SINOGEL Amino Acid Co., Ltd.(China) is located in Huaibei Economic Development Zone,Anhui,China.It is found in June,2008,the registered capital is US$4.65million.The main products are L-Alanine,DL-Alanine and L-Asparitic acid.
saya seorang yang lactose pada susu tepung...masa pregnant kan Umar Asif,saya daha try semua jenis susu tepung tapi semua saya lactose..aper itu lactose?kesan nyer mcm mn?----sebelum saya tahu saya seorang yang lactose pada susu tepung ni,saya try minum susu mamil tp kesan nyer saya sakit perut,buang air besar cirit sikit,kentut busuk(sori klu bunyi mcm kotor,sekadar perkongsian jer tau),pastu saya try susu enfa n semua yang lain pon sama kesan nyer...last sekali saya jumpa doctor n bagi tau nyer dan rupe² nyer saya lactose pada susu,perut saya xleh sesuai ngan susu tepung..jadi akhirnyer saya minum HL,tu pun permulaannyer kesannyer masih sama tapi x ketara sgt so saya proceed HL dan juga DUTCH LADY dalam kotak tu sahaja sb memula sahaja saya sakit perut pastu ok dan ok...sampai bertimbun² kotak² itu semua di celah sudut umah saya masa tu..tapi kali ni,suami saya masih lagi cadangkan susu tepung,tapi saya xyakin takut rugi nnti beli pastu tercirit pastu x minum..klu ader yang mcm 3 in 1 tu ok ...
well spanjang demam yg tak leh handle hari tuh mmg aku nangis , sebab sakit sangat . rasa cam nak pecah kepala jer...n jgn marah yer smua saya tak gie klinik just amik panadol sebab saya nie DEGIL org nyer just ader satu hari tuh ...memmg saya tak tido spanjang malam because sakit n couldnt take it anymore,......dah lah sakit yg menambah peritnya...takder tmpt mgadu...pon...mula lah masa tuh macam bermain di kepala hotak berkecamuk semua nya jadi..... mmg nangis tak ingat n i meraung panggil my mum...n hoping to fall a sleep ....but it takes time ...
Converted from rat to human using ortholog information, originally from KEGG. Originally edited by Sebastien Burel. This pathway describes the degradation of alanine and aspartate. Alanine is broken down by oxidative deamination, the inverse reaction of the reductive amination biosynthesis, catalyzed by the same enzymes. Proteins on this pathway have targeted assays available via the CPTAC Assay Portal ...
Alan Alda is Trying to Find the Next Carl Sagan Miles OBrien reports on a contest created by actor Alan Alda, which challenges scientists to flex their communication muscles by answering the seemingly simple question, What is a flame? Thousands of 11-year-olds serve as judges.. ...
I had this album and really liked it. I wish I could find it in a digital format. Id buy it again. I had a penchant for somewhat obscure bands in those days, I guess I still do. Totally disagree with any Roxy music comparison. As I recall, its been a while, they seemed to bridge that spot between the rock and roll of the day and the hard core new wave, sometimes ahead of the curve and sometimes woefully behind. But the album was entertaining and definitaly listenable. For some reason overnight jets has stayed with me... ...
I had this album and really liked it. I wish I could find it in a digital format. Id buy it again. I had a penchant for somewhat obscure bands in those days, I guess I still do. Totally disagree with any Roxy music comparison. As I recall, its been a while, they seemed to bridge that spot between the rock and roll of the day and the hard core new wave, sometimes ahead of the curve and sometimes woefully behind. But the album was entertaining and definitaly listenable. For some reason overnight jets has stayed with me... ...
Expression of AKR1B1 (ALDR1, AR) in colon tissue. Antibody staining with HPA026425, HPA052751, CAB027391 and CAB047353 in immunohistochemistry.
To know about L Alanine - L-Alanine is non-polar amino acid. L-Alanine synthesized by the muscle cells from lactic acid and plays a vital role as a building block
You are viewing an interactive 3D depiction of the molecule 3-(3-hydroxy-2-oxo-2,3-dihydro-1h-indol-3-yl)-l-alanine (C11H12N2O4) from the PQR.
Symptomatic Women with ALD Bootcamp August 7, 2021 Register here: https://events.r20.constantcontact.com/register/eventReg?oeidk=a07ei9g462x0097a356&oseq=&c=&ch= *schedule subject to change* 11:00 AM EDT WEBINAR Overview of Symptoms in Women with ALD 12:00 PM EDT WEBINAR Symptom Management 1:00 PM EDT WEBINAR Coping with an ALD Diagnosis 2:00 PM EDT WEBINAR Looking Ahead: Future studies 3:00 PM EDT OPEN DISCUSSION Ask…. ...
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L-alanine dehydrogenase, NAD+-linked alanine dehydrogenase, alpha-alanine dehydrogenase, NAD+-dependent alanine dehydrogenase, ... alanine oxidoreductase, and NADH-dependent alanine dehydrogenase. T Alanine dehydrogenase contains both a N-terminus and C- ... Alanine dehydrogenase (EC 1.4.1.1) is an enzyme that catalyzes the chemical reaction L-alanine + H2O + NAD+ ⇌ {\displaystyle \ ... O'Connor RJ, Halvorson H (March 1961). "The substrate specificity of L-alanine dehydrogenase". Biochimica et Biophysica Acta. ...
This is confirmed by the presence of glutamine synthetase, glutamate synthase, and alanine dehydrogenase. Since M. scandinavica ... The TCA cycle is incomplete due to the inactivity of the α-ketoglutarate dehydrogenase enzyme. M. scandinavica also uses ...
Dando PR (1981). "Strombine [N-(carboxymethyl)-D-alanine] dehydrogenase and alanopine [meso-N-(1-carboxyethyl)-alanine] ... alanine]dehydrogenase, meso-N-(1-carboxyethyl)-alanine:NAD+ oxidoreductase, alanopine: NAD+ oxidoreductase, ADH, and alanopine: ... Alanopine dehydrogenase (EC 1.5.1.17) is an enzyme that catalyzes the chemical reaction 2,2'-iminodipropanoate + NAD+ + H2O ... Its 4 products are L-alanine, pyruvate, nicotinamide adenine dinucleotide, and hydrogen ion. This enzyme belongs to the family ...
... alanine transaminase and lactic dehydrogenase. Diagnosis is made by estimating the acid alpha glucosidase activity in either ...
Transamination by alanine transaminase produces alanine. Reduction by lactate dehydrogenase produces lactate. Pyruvic acid is ... It can also be used to construct the amino acid alanine and can be converted into ethanol or lactic acid via fermentation. ... Jaimes, R., III (Jul 2015). "Functional response of the isolated, perfused normoxic heart to pyruvate dehydrogenase activation ... Pyruvate from glycolysis is converted by fermentation to lactate using the enzyme lactate dehydrogenase and the coenzyme NADH ...
... pyruvate is either converted into alanine via alanine aminotransferase or converted into lactic acid by lactate dehydrogenase; ... Leigh syndrome can also be caused by deficiency of the pyruvate dehydrogenase complex (PDHC), most commonly involving a PDHC ... Thiamine (vitamin B1) may be given if pyruvate dehydrogenase deficiency is known or suspected. The symptoms of lactic acidosis ... Laboratory findings of lactic acidosis or acidemia and hyperalaninemia (elevated levels of alanine in the blood) can also ...
Methylmalonate semialdehyde dehydrogenase deficiency is characterized by elevated beta-alanine, 3-hydroxypropionic acid, and ... demonstration of defective valine and beta-alanine metabolism and reduced malonic semialdehyde dehydrogenase activity in ... "CoA-dependent methylmalonate-semialdehyde dehydrogenase, a unique member of the aldehyde dehydrogenase superfamily. cDNA ... "CoA-dependent methylmalonate-semialdehyde dehydrogenase, a unique member of the aldehyde dehydrogenase superfamily. cDNA ...
Dando PR (1981). "Strombine [N-(carboxymethyl)-D-alanine] dehydrogenase and alanopine [meso-N-(1-carboxyethyl)-alanine ... D-alanine]dehydrogenase, and N-(carboxymethyl)-D-alanine: NAD+ oxidoreductase. ... In enzymology, a strombine dehydrogenase (EC 1.5.1.22) is an enzyme that catalyzes the chemical reaction N-(carboxymethyl)-D- ... The systematic name of this enzyme class is N-(carboxymethyl)-D-alanine:NAD+ oxidoreductase (glycine-forming). Other names in ...
In E. coli K12 D-amino acid dehydrogenase is most active with D-alanine as its substrate, as this amino acid is the sole source ... For example, it was found that specifically D-alanine dehydrogenases from E. coli and P. aeruginosa would lose most of their ... Solubilized D-amino acid dehydrogenase tends to increase its affinity for D-alanine, D-asparagine, and D- α {\displaystyle \ ... Obtaining D-Amino Acid Dehydrogenase In one study, in order to test the viability of using D-amino dehydrogenase in synthesis ...
... alanine aminotransferase, and lactate dehydrogenase are closely examined. Abnormal levels of these proteins are indicative of ... Muscle enzymes are increased, commonly lactate dehydrogenase (LDH). Many dietary factors and aberrations can induce ANIM. ...
This enzyme participates in beta-alanine metabolism. Nakamura K, Bernheim F (June 1961). "Studies on malonic semialdehyde ... In enzymology, a malonate-semialdehyde dehydrogenase (EC 1.2.1.15) is an enzyme that catalyzes the chemical reaction 3- ... dehydrogenase from Pseudomonas aeruginosa". Biochimica et Biophysica Acta. 50: 147-52. doi:10.1016/0006-3002(61)91071-X. PMID ...
This enzyme participates in beta-alanine metabolism and propanoate metabolism. Den H, Robinson WG, Coon MJ (1959). "Enzymatic ... In enzymology, a 3-hydroxypropionate dehydrogenase (EC 1.1.1.59) is an enzyme that catalyzes the chemical reaction 3- ...
Alanine and lactate are major gluconeogenic precursors that enter gluconeogenesis as pyruvate. The high NADH/NAD+ ratio shifts ... Lactate dehydrogenase-A deficiency is caused by a mutation to the LDHA gene, while lactate dehydrogenase-B deficiency is caused ... Wilks HM, Holbrook JJ (December 1988). "A Specific, Highly Active Malate Dehydrogenase by Redesign of a Lactate Dehydrogenase ... Ethanol is dehydrogenated to acetaldehyde by alcohol dehydrogenase, and further into acetic acid by acetaldehyde dehydrogenase ...
It also participates in beta-alanine metabolism and pantothenate and coa biosynthesis. The systematic name of this enzyme class ... DHU dehydrogenase hydropyrimidine dehydrogenase dihydropyrimidine dehydrogenase (NADP+) As of late 2007, 5 structures have been ... dihydrothymine dehydrogenase dihydrouracil dehydrogenase (NADP+) 4,5-dihydrothymine: oxidoreductase DPD DHPDH dehydrogenase, ... "Entrez Gene: DPYD dihydropyrimidine dehydrogenase". Chung T, Na J, Kim YI, Chang DY, Kim YI, Kim H, Moon HE, Kang KW, Lee DS, ...
The malonate semialdehyde can then be converted into malonate via malonate-semialdehyde dehydrogenase. Malonate is then ... α-alanine). The IUPAC name for β-alanine is 3-aminopropanoic acid. Unlike its counterpart α-alanine, β-alanine has no ... histidine and β-alanine. Hence, by weight, only about 40% of the dose is available as β-alanine. Because β-alanine dipeptides ... β-alanine > taurine ≫ alanine, L-serine > proline). β-alanine has five known receptor sites, including GABA-A, GABA-C a co- ...
"Activity of human dihydrolipoamide dehydrogenase is largely reduced by mutation at isoleucine-51 to alanine". Journal of ... "How dihydrolipoamide dehydrogenase-binding protein binds dihydrolipoamide dehydrogenase in the human pyruvate dehydrogenase ... "How dihydrolipoamide dehydrogenase-binding protein binds dihydrolipoamide dehydrogenase in the human pyruvate dehydrogenase ... Dihydrolipoamide dehydrogenase (DLD), also known as dihydrolipoyl dehydrogenase, mitochondrial, is an enzyme that in humans is ...
This enzyme participates in urea cycle and metabolism of amino groups and beta-alanine metabolism. It has 2 cofactors: FAD, and ... IIE2a Speridine dehydrogenase". Adv. Enzymol. Relat. Areas Mol. Biol. 36: 225-226. Portal: Biology v t e (EC 1.5.99, Flavin ... In enzymology, a spermidine dehydrogenase (EC 1.5.99.6) is an enzyme that catalyzes the chemical reaction spermidine + acceptor ... "Identification of flavin adenine dinucleotide and heme in a homogeneous spermidine dehydrogenase from Serratia marcescens". J. ...
This enzyme participates in the urea cycle and the metabolism of amino groups and beta-alanine. Callewaert, Denis M.; ... ABAL dehydrogenase, 4-aminobutyraldehyde dehydrogenase, 4-aminobutanal dehydrogenase, gamma-aminobutyraldehyde dehydrogenase, 1 ... In enzymology, an aminobutyraldehyde dehydrogenase (EC 1.2.1.19) is an enzyme that catalyzes the chemical reaction 4- ... Prieto MI, Martin J, Balana-Fouce R, Garrido-Pertierra A (1987). "Properties of gamma-aminobutyraldehyde dehydrogenase from ...
N-acetylmuramoyl-L-alanine amidase, NAD(P)H dehydrogenase (quinone), superoxide dismutase, glutathione transferase, class 3 ... aldehyde dehydrogenase, glucose-6-phosphate isomerase, and tissue kallikrein (function unknown) Cells: possibly as many as 8 ...
... and dihydrouracil dehydrogenase (NAD+). This enzyme participates in 3 metabolic pathways: pyrimidine metabolism, beta-alanine ... Other names in common use include dehydrogenase, dihydrouracil, dihydropyrimidine dehydrogenase, dihydrothymine dehydrogenase, ... In enzymology, a dihydrouracil dehydrogenase (NAD+) (EC 1.3.1.1) is an enzyme that catalyzes the chemical reaction 5,6- ... Purification and properties of dihydrouracil dehydrogenase". The Journal of Biological Chemistry. 227 (2): 693-700. PMID ...
In the first step, α-ketoglutarate, ammonia and NADH are converted by glutamate dehydrogenase to glutamate, NAD+ and water. In ... Fermentation routes to L-alanine are complicated by alanine racemase. Racemic alanine can be prepared by the condensation of ... is so-called alanine scanning, where every position in turn is mutated to alanine. Hydrogenation of alanine gives the amino ... forming alanine and α-ketoglutarate. The alanine enters the bloodstream, and is transported to the liver. The alanine ...
The systematic name of this enzyme class is N-(D-1-carboxyethyl)-beta-alanine:NAD+ oxidoreductase (beta-alanine-forming). Sato ... Beta-alanopine dehydrogenase (EC 1.5.1.26) is an enzyme that catalyzes the chemical reaction beta-alanopine + NAD+ + H2O ⇌ {\ ... displaystyle \rightleftharpoons } beta-alanine + pyruvate + NADH + H+ The 3 substrates of this enzyme are beta-alanopine, ... nicotinamide adenine dinucleotide ion, and water, whereas its 4 products are beta-alanine, pyruvate, nicotinamide adenine ...
... then transaminated by alanine aminotransferase into lactate-derived pyruvate to form alanine, which is exported to astrocytes. ... The ammonia fixed as part of the glutamate dehydrogenase enzyme reaction in the neurons is transaminated into α-ketoisocaproate ... In the opposite direction of the amino acid, a corresponding molecule is transported; for alanine this molecule is lactate; for ... The ammonia produced in neurons is fixed into α-ketoglutarate by the glutamate-dehydrogenase reaction to form glutamate, ...
... beta-alanine metabolism, glycerolipid metabolism, pyruvate metabolism, 1,2-dichloroethane degradation, propanoate metabolism, 3 ... NAD-aldehyde dehydrogenase, NAD-dependent 4-hydroxynonenal dehydrogenase, NAD-dependent aldehyde dehydrogenase, NAD-linked ... Other names in common use include CoA-independent aldehyde dehydrogenase, m-methylbenzaldehyde dehydrogenase, ... aldehyde dehydrogenase, propionaldehyde dehydrogenase, and aldehyde dehydrogenase (NAD). This enzyme participates in 17 ...
The pyrimidine bases uracil and thymine are degraded via the consecutive action of dihydropyrimidine dehydrogenase (DHPDH), ... dihydropyrimidinase (DHP) and beta-ureidopropionase (UP) to beta-alanine and beta-aminoisobutyric acid, respectively. UP ...
... glutamate dehydrogenase (GlDH), EC 1.4.1.2 glutamate pyruvate transaminase (GPT), also called alanine transaminase (ALT), EC ... the malate dehydrogenase reaction and the malate decarboxylase reaction. Due to low glutamate dehydrogenase and glutamate ... and lactate dehydrogenase (LDH; EC 1.1.1.27) according to the following equations: malate + NAD(P)+→ pyruvate + NAD(P)H + H+ + ... alanine and citrate. Glutaminolysis partially recruits reaction steps from the citric acid cycle and the malate-aspartate ...
UDP-N-acetylmuramate dehydrogenase, 50S ribosomal protein L11 methyltransferase, iron-sulphur cluster-binding protein and ... alanine racemase, which in most cases are exclusively shared by either all or most members of this genus. These molecular ...
The systematic name of this enzyme class is N-methyl-L-alanine:NADP+ oxidoreductase (demethylating, deaminating). Lin MC, ... In enzymology, a N-methylalanine dehydrogenase (EC 1.4.1.17) is an enzyme that catalyzes the chemical reaction N-methyl-L- ... H+ The 3 substrates of this enzyme are N-methyl-L-alanine, H2O, and NADP+, whereas its 4 products are pyruvate, methylamine, ... Wagner C (1975). "Purification and characterization of N-methylalanine dehydrogenase". J. Biol. Chem. 250 (10): 3746-51. PMID ...
The resulting Pyruvate is transaminated to alanine, diffusing to the mesophyll. Alanine is finally transaminated to pyruvate ( ... This cycle bypasses the reaction of malate dehydrogenase in the mesophyll and therefore does not transfer reducing equivalents ...
These six are alanine, aspartic acid, asparagine, glutamic acid, serine, and selenocysteine (considered the 21st amino acid). ... Glutamate dehydrogenase catalyzes the reductive amination of α-ketoglutarate to glutamate. A transamination reaction takes ... Alanine and aspartate are synthesized by the transamination of pyruvate and oxaloacetate, respectively. Glutamine is ...
UMP synthesis from orotic acid or uridine and conversion of uracil to beta-alanine: enzymes and cDNAs. Progress in Nucleic Acid ... dihydropyrimidine dehydrogenase, thymidine phosphorylase, and orotate phosphoribosyl transferase in prostate cancer". Prostate ... "Both gene expression for orotate phosphoribosyltransferase and its ratio to dihydropyrimidine dehydrogenase influence outcome ...
The degradation of L-leucine in the muscle to this compound allows for the production of the amino acids alanine and glutamate ... This is disease is caused by a partial branched-chain alpha-keto acid dehydrogenase deficiency, which leads to a buildup of ... whereas the dehydrogenase enzyme is found exclusively in the mitochondrion (Sabourin and Bieber 1981, 1983). Importantly, this ...
In a later stage of cholestasis aspartate transaminase (AST), alanine transaminase (ALT) and unconjugated bilirubin may be ... February 1995). "Heterogeneity of autoreactive T cell clones specific for the E2 component of the pyruvate dehydrogenase ... the E2 subunit of mitochondrial pyruvate dehydrogenase complex) may be a trigger for PSC. Specifically, PDC-E2 in apoptotic ...
Stalvey JR (July 2002). "Inhibition of 3beta-hydroxysteroid dehydrogenase-isomerase in mouse adrenal cells: a direct effect of ... Hsu YC, Tai DI (2011). "Unusually high alanine aminotransferase to aspartate aminotransferase ratio in a patient with ...
This causes an alanine to valine residue substitution at amino acid position 114, a location highly conserved in all organisms ... In addition, it removes the inhibition of steroidogenic enzymes like 3β-hydroxysteriod dehydrogenase and 17α-hydroxylase. ...
Alanine can also be used as a precursor of glyceroneogenesis because alanine can be degraded to pyruvate. Alanine will degrade ... First of all, glutamate can be converted to 2-oxoglutarate with expense of NAD+ and H2O with help of glutamate dehydrogenase. ... Alanine aminotransferase will cleave off the amino group from alanine and binds it to 2-oxoglutarate which generates pyruvate ... Glyceroneogenesis uses pyruvate, alanine, glutamine or any substances from the TCA cycle as precursors for glycerol 3-phosphate ...
P. falciparum lactate dehydrogenase (PfLDH) is a 33 kDa oxidoreductase [EC 1.1.1.27]. It is the last enzyme of the glycolytic ... The histidine-rich protein II (HRP II) is a histidine- and alanine-rich, water-soluble protein, which is localized in several ... Glutamate dehydrogenase provides an oxidizable carbon source used for the production of energy as well as a reduced electron ... Bzik DJ, Fox BA, Gonyer K (1993). "Expression of Plasmodium falciparum lactate dehydrogenase in Escherichia coli". Mol Biochem ...
Some studies have revealed that the expression of Pyrubate dehydrogenase kinase (PDK), which is an enzymatic regulator in some ... there is a change of an aspartic acid to an alanine) that completely alters the formation of the CNNM3-PRL 2 complex is ... Sun, Hong; Zhu, Anyou; Zhou, Xiang; Wang, Fengchao (2017-04-10). "Suppression of pyruvate dehydrogenase kinase-2 re-sensitizes ...
Alanine (Ala, A), Arginine (Arg, R), Asparagine (Asn, N), Aspartic acid (Asp, D), Cysteine (Cys, C), Glutamic acid (Glu, E), ... "Nucleotide sequence of rat mitochondrial NADH dehydrogenase subunit 1. GTG, a new initiator codon in vertebrate mitochondrial ...
ALP and GGT levels typically rise with one pattern while aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ... Pathologic causes of neonatal jaundice include: Formula jaundice Hereditary spherocytosis Glucose-6-phosphate dehydrogenase ... Sickle-cell anemia Spherocytosis Thalassemia Pyruvate kinase deficiency Glucose-6-phosphate dehydrogenase deficiency ...
This also supports the role of β-alanine as a neurotransmitter that promotes sleep in mice. The quality of sleep may be ... For instance, mice lacking dihydropyrimidine dehydrogenase (Dpyd) had 78.4 min less sleep during the lights-off period than ... Dpyd encodes the rate-limiting enzyme in the metabolic pathway that catabolizes uracil and thymidine to β-alanine, an ... December 2021). "The dihydropyrimidine dehydrogenase gene contributes to heritable differences in sleep in mice". Current ...
... hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha ... alanine-glyoxylate aminotransferase (oxalosis I; hyperoxaluria I; glycolicaciduria; serine-pyruvate aminotransferase) ALS2: ... Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial MTIF2: mitochondrial translational ... subunit HADHB: hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional ...
This MT-ND6 G14459A mutation replaces the amino acid alanine with the amino acid valine at protein position 72 in the NADH- ... This mutation changes a single amino acid in the NADH dehydrogenase 6 protein at position 64, from methionine to valine. The ... MT-ND6 is one of seven mitochondrial genes encoding subunits of the enzyme NADH dehydrogenase (ubiquinone), together with MT- ... Jun AS, Brown MD, Wallace DC (June 1994). "A mitochondrial DNA mutation at nucleotide pair 14459 of the NADH dehydrogenase ...
Alcohol dehydrogenase (NAD) EC 1.1.1.1 Alcohol dehydrogenase (NADP) EC 1.1.1.2 Homoserine dehydrogenase EC 1.1.1.3 ... EC 2.6.1 Alanine transaminase EC 2.6.1.2 Aspartate transaminase EC 2.6.1.1 Category:EC 2.7.2 Butyrate kinase (EC 2.7.2.7) EC ... Acetaldehyde dehydrogenase EC 1.2.1.10 Glyceraldehyde 3-phosphate dehydrogenase EC 1.2.1.12 Pyruvate dehydrogenase EC 1.2.1.51 ... L-xylulose reductase EC 1.1.1.10 Lactate dehydrogenase EC 1.1.1.27 Malate dehydrogenase EC 1.1.1.37 Isocitrate dehydrogenase EC ...
... is a derivative of the amino acids arginine and alanine. It was the first member of the class of chemical compounds ... "A Structural Basis for Substrate Selectivity and Stereoselectivity in Octopine Dehydrogenase from Pecten maximus". Journal of ... by reductive condensation of pyruvic acid and arginine through the action of the NADH-dependent enzyme octopine dehydrogenase ( ...
Rash Alanine aminotransferase increased Aspartate aminotransferase increased Fractures Hematuria Uncommon (0.1-1% frequency): ... 3β-Hydroxysteroid dehydrogenase inhibitors, 5α-Reductase inhibitors, Acetate esters, Androstanes, Antiestrogens, ...
Homochirality may have started in outer space, as on the Murchison meteorite the amino acid L-alanine is more than twice as ... Its key enzyme unit, carbon monoxide dehydrogenase/acetyl-CoA synthase, contains mixed nickel-iron-sulfur clusters in its ...
L-alanine + H2O This enzyme contains pyridoxal phosphate. Bittner F, Oreb M, Mendel RR (November 2001). "ABA3 is a molybdenum ... cofactor sulfurase required for activation of aldehyde oxidase and xanthine dehydrogenase in Arabidopsis thaliana". The Journal ...
... or sinapyl-alcohol dehydrogenase (SAD). Coniferyl alcohol is then converted to an ester in the presence of the substrate ... ATPase activity and alanine absorption in the rat jejunum". Food and Chemical Toxicology. 38 (9): 755-62. doi:10.1016/S0278- ... Coniferaldeyhyde is then further reduced to coniferyl alcohol by cinnamyl-alcohol dehydrogenase (CAD) ...
... releasing the terminal D-alanine unit in the process. The structure of ceftriaxone mimics the D-alanyl-D-alanine moiety, and ... Acetaldehyde dehydrogenase inhibitors, Cephalosporin antibiotics, Hoffmann-La Roche brands, Thiazoles, Triazines, World Health ... PBPs act on a terminal D-alanyl-D-alanine moiety on a pentapeptide unit and catalyze the formation of a peptide bond between ... the PBP attacks the beta-lactam ring in ceftriaxone as if it were its normal D-alanyl-D-alanine substrate. The peptidoglycan ...
L-alanine dehydrogenase-like. Timeline for Family c.23.12.2: L-alanine dehydrogenase-like: *Family c.23.12.2: L-alanine ... L-alanine dehydrogenase. *Family c.23.12.2: L-alanine dehydrogenase-like appears in SCOP 1.65. *Family c.23.12.2: L-alanine ... Lineage for Family c.23.12.2: L-alanine dehydrogenase-like. *Root: SCOP 1.67 *. Class c: Alpha and beta proteins (a/b) [51349 ... dehydrogenase-like appears in SCOP 1.69. *Family c.23.12.2: L-alanine dehydrogenase-like appears in the current release, SCOPe ...
Alanine dehydrogenase in mycobacteria--a preliminary report.. Autor : Kannan, K B. Katoch, V M. Bharadwaj, V P. Sharma, V D. ... Electrophoretic mobilities of alanine dehydrogenase from different species of mycobacteria were not found to be significant for ... It was found that alanine dehydrogenase was present in all species of mycobacteria tested irrespective of the fact whether they ... Kannan KB, Katoch VM, Bharadwaj VP, Sharma VD, Dutta AK, Venkatesan K. Alanine dehydrogenase in mycobacteria--a preliminary ...
Elevated levels of lactate dehydrogenase, alanine aminotransferase, and hepatic transaminase. * Elevated creatine kinase level ... Laboratory features - Including marked lymphopenia and leukocytosis, elevated lactate dehydrogenase level, hepatitis, high SARS ...
Elevated levels of aspartate aminotransferase, alanine aminotransferase, and lactate dehydrogenase. Absence of other causes. ...
Alanine dehydrogenase 2 (Ald2). Q99TF4. 1.86 ↓. 7. Phenylalanine--tRNA ligase α subunit (PheS). P68848. 1.55 ↓. ... Pyruvate dehydrogenase E1 component subunit β (PdhB). P99063. 1.84 ↓. 2.23 ↓. 12. Dihydrolipoyl dehydrogenase (PdhD). P99084. ... Glyceraldehyde-3-phosphate dehydrogenase 1 (GapA1). P99136. 1.62 ↓. * the arrow denotes the direction of regulation; ↑ up- and ... Glyceraldehyde-3-phosphate dehydrogenase 1 (GapA1). P99136. 1.5 ↓. 16. 3-hexulose-6-phosphate synthase (HPS). Q7A774. 1.92 ↓. ...
Liver function tests: Including lactic acid dehydrogenase (LDH), aspartate aminotransferase (AST), alanine aminotransferase ( ...
... alanine aminotransferase, and lactate dehydrogenase. Thirteen patients were hospitalized, and none died. Twenty-two patients ...
The l-alanine dehydrogenase of Bacillus subtilis (BasAlaDH), which is strictly dependent on NADH as redox cofactor, efficiently ... Analogues of the natural product duocarmycin bearing an indole moiety were shown to bind aldehyde dehydrogenase 1A1 (ALDH1A1) ... The thermostable NAD+-dependent alcohol dehydrogenase from Geobacillus stearothermophilus (BsADH) was exploited with regard to ... To enable application of BasAlaDH as regenerating enzyme in coupled reactions with NADPH-dependent alcohol dehydrogenases, we ...
... alanine dehydrogenase (Ald). Ald was found to be a limiting resource during starvation, which is allocated to spores and ... U = 23 (UP=0.01 = 75). c Spore revival in response to a rich nutrient stimulus (33% LB, 33% AGFK, and 33 mM l-alanine). Left: ... U = 10 (UP=0.01 = 70). c Spore revival in response to a rich nutrient stimulus (33% LB, 33% AGFK, and 33 mM l-alanine). Left: ... U = 6 (UP=0.01 = 7). d Spore revival in response to a poor nutrient stimulus (100 mM l-alanine). Left: micrograph of spore ...
Liver enzymes alanine aminotransferase and glutamate dehydrogenase increased.. In 2015, I was diagnosed with glaucoma. ...
Maximal aspartate aminotransferase, alanine aminotransferase, and kinase levels were also significantly higher in patients with ... Although abnormalities in platelet counts and lactate dehydrogenase, blood urea nitrogen, and creatinine levels tended to be ... We investigated the following values: platelet counts; aspartate aminotransferase (AST), alanine aminotransferase (ALT), ... lactate dehydrogenase, creatinine kinase, blood urea nitrogen, creatinine, glucose, and ammonia levels; and cell counts and ...
A cold-active β-galactosidase from C. maltaromaticum and a cold-adapted alanine dehydrogenase from a Carnobacterium sp. related ... A cold-active β-galactosidase from C. maltaromaticum and a cold-adapted alanine dehydrogenase from a Carnobacterium species ... A cold-active β-galactosidase from C. maltaromaticum and a cold-adapted alanine dehydrogenase from a Carnobacterium species ...
Increased serum alanine aminotransferase (ALT), aspartate aminotransferase, lactate dehydrogenase, and alkaline phosphatase ( ...
Activities of alanine aminotransferase (ALT) and isocitrate dehydrogenase (ICD) were statistically increased in both sexes of ... Activities of serum sorbitol dehydrogenase (SDH) were statistically increased in male and female rats (200 to 800 ppm) on study ...
Electromyographic examinations; measurement of plasma creatine kinase, alanine aminotransferase, aspartate aminotransferase, ... and lactate dehydrogenase 5 isoenzyme activities and was characterized by nemaline rod inclusions, substantial and progressive ... lactate, and lactate dehydrogenase isoenzyme activities; and skeletal muscle morphologic-morphometric examinations were ...
... lactate dehydrogenase, protein, urea, albumin, bilirubin, creatinine, triglycerides, and cholesterol in serum. Lipid ... alanine aminotransferase (ALT) [29], alkaline phosphatase (SALP) [30], lactate dehydrogenase (LDH) [31], and serum protein ... Alanine aminotransferase (ALT); Lactate dehydrogenase (LDH), and Alkaline phosphatase (SALP).. ... lactate dehydrogenase, protein, urea, albumin, bilirubin, creatinine, triglycerides, and cholesterol in serum. Lipid ...
BPPs reduced the serum levels of aspartate aminotransferase, alanine aminotransferase and lactate dehydrogenase in a CCl4‑ ... AST, aspartate aminotransferase; ALT, alanine aminotransferase; LDH, lactate dehydrogenase; BPP, banana peel polyphenol. ... Serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), malondialdehyde ... Tomizawa M, Kawanabe Y, Shinozaki F, Sato S, Motoyoshi Y, Sugiyama T, Yamamoto S and Sueishi M: Elevated levels of alanine ...
... alanine transaminase; LDH: lactate dehydrogenase; CRP: C‐reactive protein; IL-6: interleukine-6. ... Lactate dehydrogenase levels predict coronavirus disease 2019 (COVID-19) severity and mortality: A pooled analysis. Am J Emerg ... lactate dehydrogenase (LDH), ferritin, interleukin-6 (IL-6), and liver and kidney function tests. Repeat PCR testing was ...
The effects of pumpkin seed (Cucurbita pepo) protein isolate on the activity levels of lactate dehydrogenase (LD), alanine ...
... lactate dehydrogenase, ALT: alanine aminotransferase, AST: aspartate aminotransferase, CRP: C-reactive protein. ... lactate dehydrogenase, ALT: alanine aminotransferase, AST: aspartate aminotransferase, CRP: C-reactive protein. ...
... lactate dehydrogenase, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, bilirubin, sodium, potassium ...
Even though the ESX-5a region is required for the secretion of Alanine-L dehydrogenase (ALD), it does not contain genes ...
... dinucleotide dehydrogenase quinone 1 and alanine transaminase. The enzyme levels were significantly higher in tumor than in ... We have reported previously a high level of [1-(13)C]alanine in an orthotopic HCC using single-voxel hyperpolarized [1-(13)C] ... More importantly, the results demonstrated that the metabolic fate of [1-(13)C]pyruvate conversion to [1-(13)C]alanine ... quantitative real-time polymerase chain reaction was used to determine the mRNA levels of lactate dehydrogenase A, nicotinamide ...
Elevated levels of aspartate aminotransferase, alanine aminotransferase, and lactate dehydrogenase. Absence of other causes. ...
Alanine dehydrogenase (substance). Code System Preferred Concept Name. Alanine dehydrogenase (substance). Concept Status. ...
  • Thirteen patients had mild serum elevations of liver enzymes aspartase aminotransferase, alanine aminotransferase, and lactate dehydrogenase. (cdc.gov)
  • Hypothyroid myopathy was associated with significant increases in plasma creatine kinase, aspartate aminotransferase, and lactate dehydrogenase 5 isoenzyme activities and was characterized by nemaline rod inclusions, substantial and progressive predominance of type I myofibers, decrease in mean type II fiber area, subsarcolemmal accumulations of abnormal mitochondria, and myofiber degeneration. (avma.org)
  • BPPs reduced the serum levels of aspartate aminotransferase, alanine aminotransferase and lactate dehydrogenase in a CCl4‑induced mouse model of hepatic injury. (spandidos-publications.com)
  • Serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), malondialdehyde (MDA), glutathione (GSH) and triglyceride (TG) were evaluated, and in addition tissue levels of MDA, GSH and TG were determined. (spandidos-publications.com)
  • In addition, plasma activities of alanine transaminase ( P = .046), lactate dehydrogenase ( P = .039), and creatine kinase ( P = .030) were significantly lower after 6 months in the 50 g/day dried plum group. (nih.gov)
  • Elevated levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and lactate dehydrogenase (LDH) in patients with nonspecific symptoms often direct attention to liver disease. (rheumatologynetwork.com)
  • Abnormal levels of at least 1 of the following enzymes: creatine kinase (CK), aldolase, lactate dehydrogenase, aspartate aminotransaminase (AST), alanine aminotransferase (ALT), based on central laboratory results b. (who.int)
  • Our results showed that all dosages induced no significant alterations in growth parameters and the seric levels of total protein, albumin, globulin, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol and triglycerides and activities of glutamic pyruvic transaminase, glutamic oxaloacetic transaminase, alkaline phosphatase and lactate dehydrogenase, when compared to the control group. (blogspot.com)
  • tate dehydrogenase, and creatine kinase. (cdc.gov)
  • Her alanine aminotransferase level was 46 U/L, aspartate aminotransferase level 120 U/L, and lactic acid dehydrogenase level 274 U/L. (medscape.com)
  • The activity of hexokinase, lactic dehydrogenase, isocitric dehydrogenase malic enzyme, 6-phospho-gluconic dehydrogenase, alanine transaminase and aspartase has been studied in the basaliomas using quantitative histochemical methods. (elsevier.com)
  • Activities of serum sorbitol dehydrogenase (SDH) were statistically increased in male and female rats (200 to 800 ppm) on study days 4, 24, and 91 (13 weeks). (cdc.gov)
  • Association of 11ß-hydroxysteroid dehydrogenase type 1 gene polymorphisms with serum alanine aminotransferase activity. (cdc.gov)
  • Various mycobacterial species namely M. phlei, M. vaccae, M. scrofulaceum, M. avium and M. tuberculosis have been investigated for the presence of enzyme alanine dehydrogenase which could be important for utilization of alanine by TCA cycle. (who.int)
  • An NAD -dependent enzyme that catalyzes the reversible DEAMINATION of L-ALANINE to PYRUVATE and AMMONIA . (bvsalud.org)
  • The enzyme is needed for growth when ALANINE is the sole CARBON or NITROGEN source. (bvsalud.org)
  • Liver function enzymes, aspartate aminotransferase, and alanine aminotransferase activities including total cholesterol, total protein, albumin, and globulin were not changed by BV supplementation. (blogspot.com)
  • Overview: GapMind describes D-alanine catabolism via D-alanine dehydrogenase, which forms pyruvate. (lbl.gov)
  • In principle, D-alanine might also be catabolized via racemization to L-alanine and transamination to pyruvate, but this is not described here. (lbl.gov)
  • When elevated above normal values, the ALT (alanine aminotransferase) and AST (aspartate aminotransferase) tests indicate liver damage. (hepa-merz.com)
  • The MT-ND4L gene provides instructions for making a protein called NADH dehydrogenase 4L. (medlineplus.gov)
  • This mutation, which can be written as T10663C or Val65Ala, changes a single protein building block (amino acid) in the NADH dehydrogenase 4L protein. (medlineplus.gov)
  • Specifically, it replaces the amino acid valine with the amino acid alanine at protein position 65. (medlineplus.gov)
  • Penicillin-binding protein 5, D-alanyl-D-alanine carboxypeptidase [Interproscan]. (ntu.edu.sg)
  • SLBB domain, 4Fe-4S dicluster domain, RnfC Barrel sandwich hybrid domain, Respiratory-chain NADH dehydrogenase 51 Kd subunit [Interproscan]. (ntu.edu.sg)
  • Even though the ESX-5a region is required for the secretion of Alanine-L dehydrogenase (ALD), it does not contain genes encoding for the components of a secretion system. (umd.edu)
  • N-acetylmuramoyl-L-alanine amidase [Interproscan]. (ntu.edu.sg)
  • Acyl-CoA dehydrogenase, Domain of unknown function (DUF1974) [Interproscan]. (ntu.edu.sg)
  • Aldehyde dehydrogenase family [Interproscan]. (ntu.edu.sg)
  • It was found that alanine dehydrogenase was present in all species of mycobacteria tested irrespective of the fact whether they are rapid or slow growers. (who.int)
  • Electrophoretic mobilities of alanine dehydrogenase from different species of mycobacteria were not found to be significant for taxonomical differentiation of rapid and slow growers. (who.int)
  • Alliin, S-allyl-N-acetyl cysteine, S-allylsulfonyl alanine, and S-methyl cysteine had no effect on cholesterol synthesis. (nih.gov)
  • This reaction is part of the MetaCyc pathway for L-alanine catabolism via D-alanine ( link ). (lbl.gov)
  • DPD constitutes the first step of the pyrimidine degradation pathway, in which the pyrimidine bases uracil and thymine are catabolized to beta-alanine and the R-enantiomer of beta-aminoisobutyric acid respectively. (hmdb.ca)
  • It has been suggested that altered homeostasis of beta-alanine underlies some of the clinical abnormalities encountered in patients with a dihydropyrimidine dehydrogenase (DPD) deficiency. (hmdb.ca)
  • Maximal aspartate aminotransferase, alanine aminotransferase, and kinase levels were also significantly higher in patients with diffuse lesions. (ajnr.org)
  • Genetic Variation in the 11ß-hydroxysteroid-dehydrogenase 1 Gene Determines NAFLD and Visceral Obesity. (cdc.gov)
  • Activities of alanine aminotransferase (ALT) and isocitrate dehydrogenase (ICD) were statistically increased in both sexes of rats exposed to 800 ppm DMF at all time points. (cdc.gov)
  • L-alanine = 499 reactions were found. (tu-bs.de)
  • It may also play a role in CELL WALL synthesis because L-ALANINE is an important constituent of the PEPTIDOGLYCAN layer. (bvsalud.org)
  • Comment: Transporters were identified using: query: transporter:D-alanine:D-ala. (lbl.gov)
  • Males also showed statistically significant decreases in sorbitol dehydrogenase activity at 400 ppm, alanine aminotransferase activity at levels ≥50 ppm, and alkaline phosphatase activity at levels ≥100 ppm. (europa.eu)
  • Alanine aminotransferase activity was decreased at ≥200 ppm, and alkaline phosphatase activity decreased at the 400 ppm, in females. (europa.eu)
  • In seven cases, blood samples taken during or shortly before surgery were analysed for concentrations of alpha-amylase, 1,2-o-dilauryl-rac-glycero-3-glutaric acid-(6'-methylresorufin) ester lipase (DGGR lipase), C-reactive protein (CRP), alanine aminotransferase, glutamate dehydrogenase, alkaline phosphatase (ALP), canine trypsin-like immunoreactivity (cTLI) and canine pancreatic lipase immunoreactivity (cPLI). (laboklin.com)
  • Serum alanine aminotransferase (ALT), an indicator of hepatocellular injury, has been suggested as a surrogate marker for NAFLD. (nih.gov)
  • Activities of serum sorbitol dehydrogenase (SDH) were statistically increased in male and female rats (200 to 800 ppm) on study days 4, 24, and 91 (13 weeks). (cdc.gov)
  • Male mice treated with 3 and 6 mg/kg-day and females treated with 6 mg/kg-day demonstrated significantly elevated serum markers of liver injury including alanine aminotransferase (ALT), glutamate dehydrogenase (GLDH), and liver/body weight percent. (pfascentral.org)
  • Co-treatment with LPS and Aroclor 1248 resulted in pronounced liver injury as demonstrated from increased activities of alanine aminotransferase and isocitrate dehydrogenase in plasma. (nih.gov)
  • Activities of alanine aminotransferase (ALT) and isocitrate dehydrogenase (ICD) were statistically increased in both sexes of rats exposed to 800 ppm DMF at all time points. (cdc.gov)
  • May contribute to beta-alanine production via aldehyde dehydrogenase conversion of 3-amino-propanal. (nih.gov)
  • Objective Aldehyde dehydrogenase 2 (ALDH2), a key enzyme to detoxify acetaldehyde in the liver, exists in both active and inactive forms in humans. (bmj.com)
  • In vivo, l -glutamine and l -alanine are quantitatively the most abundant amino acids in the blood and extracellular fluids followed closely by the branched chain amino acids ( 6 ). (diabetesjournals.org)
  • Since there is only one dehydrogenase enzyme for all three amino acids, all three a-keto acids accumulate and are excreted in the urine. (drugbank.com)
  • Little alteration was found in alanine aminotransferase and UDP-glucose dehydrogenase activity in the lesion. (elsevier.com)
  • Name": "CB - Order Information" }, { "Language": "en", "Value": "Recombinant dehydrogenase, that catalyzes the oxidation of Glucose-6-phosphate. (roche.com)
  • Pyruvate dehydrogenase complex (PDC) deficiency (PDCD) is one of the most common neurodegenerative disorders associated with abnormal mitochondrial metabolism. (medscape.com)
  • Pyruvate dehydrogenase complex (PDC) converts pyruvate to ACoA, which is one of the two essential substrates needed to produce citrate (see the image below). (medscape.com)
  • 0:28:02 Thiamin's role in energy metabolism: pyruvate dehydrogenase, alpha-ketoglutarate dehydrogenase, and branched-chain alpha-keto acid dehydrogenase. (substack.com)
  • This indicates that S. pombe has catabolic pathways for both enantiomers of alanine and that the pathway for L-alanine coupled with racemization plays a major role in the catabolism of D-alanine. (omicsdi.org)
  • Because pyruvate does not proceed to acetyl-coenzyme A (CoA), it is shunted to other pathways that produce lactic acid and alanine. (medscape.com)
  • 6. Carnosine and anserine homeostasis in skeletal muscle and heart is controlled by β-alanine transamination. (nih.gov)
  • Treponema denticola cystalysin exhibits significant alanine racemase activity accompanied by transamination: mechanistic implications. (omicsdi.org)
  • Racemization and transamination reactions were observed to occur with both alanine isomers as substrates. (omicsdi.org)
  • The catalytic efficiency of the half-transamination of L-alanine is found to be 5.3x10(-5) mM(-1) x s(-1), 5-fold higher when compared with that of D-alanine. (omicsdi.org)
  • The partition ratio between racemization and half-transamination reactions is 2.3x10(3) for L-alanine and 1.4x10(4) for D-alanine. (omicsdi.org)
  • In the reaction, ALT catalyzes the reversible transamination of L-alanine and -ketoglutarate to pyruvate and L-glutamate. (cdc.gov)
  • Functional characterization of alanine racemase from Schizosaccharomyces pombe: a eucaryotic counterpart to bacterial alanine racemase. (omicsdi.org)
  • The structure of alanine racemase from Acinetobacter baumannii. (omicsdi.org)
  • Alanine racemase (Alr) is a pyridoxal 5'-phosphate dependent enzyme that is responsible for racemization between enantiomers of alanine. (omicsdi.org)
  • The crystal structure of A. baumannii alanine racemase (AlrAba) from the highly antibiotic-resistant NCTC13302 strain has been solved to 1.9 Å resolution. (omicsdi.org)
  • The recombinant yeast was relieved from the toxicity of D-alanine. (omicsdi.org)
  • An NAD -dependent enzyme that catalyzes the reversible DEAMINATION of L-ALANINE to PYRUVATE and AMMONIA . (bvsalud.org)
  • It may also play a role in CELL WALL synthesis because L-ALANINE is an important constituent of the PEPTIDOGLYCAN layer. (bvsalud.org)
  • DPO is made from threonine and alanine, and its synthesis depends on threonine dehydrogenase (Tdh). (princeton.edu)
  • Other proteins claimed to be associated with the cell wall of mycobacteria are the 10-kDa GroES and 70-kDa DnaK homologs, SodA, alanine dehydrogenase (2), and the chaperonin 65-kDa GroEL-2 homolog (14, 20). (recob-tlse.org)
  • The enzyme is needed for growth when ALANINE is the sole CARBON or NITROGEN source. (bvsalud.org)
  • S. pombe uses D-alanine as a sole nitrogen source, but deletion of the alr1(+) gene resulted in retarded growth on the same medium. (omicsdi.org)
  • Saccharomyces cerevisiae differs markedly from S. pombe: S. cerevisiae uses L-alanine but not D-alanine as a sole nitrogen source. (omicsdi.org)
  • However, heterologous expression of the alr1(+) gene enabled S. cerevisiae to grow efficiently on D-alanine as a sole nitrogen source. (omicsdi.org)
  • These similarities suggest that antibodies which recognized the alanine dehydrogenase of Mycobacterium tuberculosis can also be directed against the membrane bound pyridine nucleotide transhydrogenase. (unamur.be)
  • Giffin MM, Shi L, Gennaro ML, Sohaskey CD.Role of Alanine Dehydrogenase of Mycobacterium tuberculosis during Recovery from Hypoxic Nonreplicating Persistence. (fudan.edu.cn)
  • Additionally, it was observed that those hospitalised with COVID-19 have elevated levels of lactic dehydrogenase, α-hydroxybutyrate dehydrogenase, alanine aminotransferase, and γ-glutamyltransferase. (fitterfly.com)
  • however, high levels of deuterium enrichment were detected in all presented molecules - for phenylalanine the enrichment was six, leucine/isoleucine - 5.1, valine - 4.7, and alanine - 3.1 deuterium atoms. (ukrreferat.com)
  • use ACYLTRANSFERASES 1973-1979, use COENZYME A & PHOSPHOLIPIDS 1973-1978 MH - 1-Pyrroline-5-Carboxylate Dehydrogenase UI - D050842 MN - D8.811.682.662.693 MS - An enzyme that catalyzes the oxidation of 1-pyrroline-5-carboxylate to L-GLUTAMATE in the presence of NAD. (nih.gov)
  • HN - 2006(1983) MH - 2-Oxoisovalerate Dehydrogenase (Acylating) UI - D050645 MN - D8.811.682.657.350.825 MS - An NAD+ dependent enzyme that catalyzes the oxidation 3-methyl-2-oxobutanoate to 2-methylpropanoyl-CoA. (nih.gov)
  • use ANTHRANILIC ACID 1974-1979 MH - 3-Isopropylmalate Dehydrogenase UI - D050539 MN - D8.811.682.47.500 MS - An NAD+ dependent enzyme that catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate to 3-carboxy-4-methyl-2-oxopentanoate. (nih.gov)
  • 11β-Hydroxysteroid dehydrogenase type 1 (HSD11B1), which converts inactive glucocorticoid to active glucocorticoid, plays a critical role in pathogenesis of non-alcoholic fatty liver disease (NAFLD). (nih.gov)
  • Genetic Variation in the 11ß-hydroxysteroid-dehydrogenase 1 Gene Determines NAFLD and Visceral Obesity. (cdc.gov)
  • N o correlation between alanine dehydrogenase activity and nitrogenase activity in these other eight strains was observed. (mpg.de)
  • β-Alanopine dehydrogenase activity, which catalyzes the reductive condensation of β-alanine and pyruvate, was confirmed in this bivalve mollusc. (elsevier.com)
  • Since tissues of this bivalve showed a high β-alanopine dehydrogenase activity and contained large amounts of β-alanine, β-alanopine dehydrogenase may play an important physiological role in the regulation of cytoplasmic redox balance like other opine dehydrogenases. (elsevier.com)
  • During the reaction of cystalysin with L- or D-alanine, a time-dependent loss of beta-elimination activity occurs concomitantly with the conversion of the pyridoxal 5'-phosphate (PLP) coenzyme into pyridoxamine 5'-phosphate (PMP). (omicsdi.org)
  • 1. β-Alanine intercede metabolic recovery for amelioration of human cervical and renal tumors. (nih.gov)