Enzymes that act at a free C-terminus of a polypeptide to liberate a single amino acid residue.
A ZINC-containing exopeptidase primarily found in SECRETORY VESICLES of endocrine and neuroendocrine cells. It catalyzes the cleavage of C-terminal ARGININE or LYSINE residues from polypeptides and is active in processing precursors of PEPTIDE HORMONES and other bioactive peptides.
A ZINC-dependent carboxypeptidase primary found in the DIGESTIVE SYSTEM. The enzyme catalyzes the preferential cleavage of a C-terminal peptidyl-L-lysine or arginine. It was formerly classified as EC 3.4.2.2 and EC 3.4.12.3.
Carboxypeptidases that are primarily found the DIGESTIVE SYSTEM that catalyze the release of C-terminal amino acids. Carboxypeptidases A have little or no activity for hydrolysis of C-terminal ASPARTIC ACID; GLUTAMIC ACID; ARGININE; LYSINE; or PROLINE. This enzyme requires ZINC as a cofactor and was formerly listed as EC 3.4.2.1 and EC 3.4.12.2.
A metallocarboxypeptidase that removes C-terminal basic amino acid from peptides and proteins, with preference shown for lysine over arginine. It is a plasma zinc enzyme that inactivates bradykinin and anaphylatoxins.
A carboxypeptidase that catalyzes the release of a C-terminal amino acid with a broad specificity. It also plays a role in the LYSOSOMES by protecting BETA-GALACTOSIDASE and NEURAMINIDASE from degradation. It was formerly classified as EC 3.4.12.1 and EC 3.4.21.13.
A metallocarboxypeptidase that is predominantly expressed as a membrane-bound enzyme. It catalyzes the hydrolysis of an unsubstituted, C-terminal glutamyl residue, typically from PTEROYLPOLYGLUTAMIC ACIDS. It was formerly classified as EC 3.4.19.8.
A metallocarboxypeptidase that removes C-terminal lysine and arginine from biologically active peptides and proteins thereby regulating their activity. It is a zinc enzyme with no preference shown for lysine over arginine. Pro-carboxypeptidase U in human plasma is activated by thrombin or plasmin during clotting to form the unstable carboxypeptidase U.
Catalyzes the hydrolysis of pteroylpolyglutamic acids in gamma linkage to pterolylmonoglutamic acid and free glutamic acid. EC 3.4.19.9.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Enzyme which catalyzes the peptide cross-linking of nascent CELL WALL; PEPTIDOGLYCAN.
The rate dynamics in chemical or physical systems.
A carboxypeptidase that is specific for proteins that contain two ALANINE residues on their C-terminal. Enzymes in this class play an important role in bacterial CELL WALL biosynthesis.
A characteristic feature of enzyme activity in relation to the kind of substrate on which the enzyme or catalytic molecule reacts.
Any spaces or cavities within a cell. They may function in digestion, storage, secretion, or excretion.
Compounds which inhibit or antagonize biosynthesis or actions of proteases (ENDOPEPTIDASES).
A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM.
Peptides composed of two amino acid units.
The parts of a macromolecule that directly participate in its specific combination with another molecule.
Physiologically inactive substances that can be converted to active enzymes.
The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH = log 1/2[1/(H+)], where (H+) is the hydrogen ion concentration in gram equivalents per liter of solution. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
A penicillin derivative commonly used in the form of its sodium or potassium salts in the treatment of a variety of infections. It is effective against most gram-positive bacteria and against gram-negative cocci. It has also been used as an experimental convulsant because of its actions on GAMMA-AMINOBUTYRIC ACID mediated synaptic transmission.
The process of cleaving a chemical compound by the addition of a molecule of water.
A species of the genus SACCHAROMYCES, family Saccharomycetaceae, order Saccharomycetales, known as "baker's" or "brewer's" yeast. The dried form is used as a dietary supplement.
A subclass of PEPTIDE HYDROLASES that catalyze the internal cleavage of PEPTIDES or PROTEINS.
A subclass of lipid-linked proteins that contain a GLYCOSYLPHOSPHATIDYLINOSITOL LINKAGE which holds them to the CELL MEMBRANE.
Serum peptides derived from certain cleaved COMPLEMENT PROTEINS during COMPLEMENT ACTIVATION. They induce smooth MUSCLE CONTRACTION; mast cell HISTAMINE RELEASE; PLATELET AGGREGATION; and act as mediators of the local inflammatory process. The order of anaphylatoxin activity from the strongest to the weakest is C5a, C3a, C4a, and C5a des-arginine.
Organic compounds that generally contain an amino (-NH2) and a carboxyl (-COOH) group. Twenty alpha-amino acids are the subunits which are polymerized to form proteins.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
A metallic element of atomic number 30 and atomic weight 65.38. It is a necessary trace element in the diet, forming an essential part of many enzymes, and playing an important role in protein synthesis and in cell division. Zinc deficiency is associated with ANEMIA, short stature, HYPOGONADISM, impaired WOUND HEALING, and geophagia. It is known by the symbol Zn.
Partial proteins formed by partial hydrolysis of complete proteins or generated through PROTEIN ENGINEERING techniques.
A serine endopeptidase that is formed from TRYPSINOGEN in the pancreas. It is converted into its active form by ENTEROPEPTIDASE in the small intestine. It catalyzes hydrolysis of the carboxyl group of either arginine or lysine. EC 3.4.21.4.
The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).
An inhibitor of glutamate decarboxylase. It decreases the GAMMA-AMINOBUTYRIC ACID concentration in the brain, thereby causing convulsions.
A nodular organ in the ABDOMEN that contains a mixture of ENDOCRINE GLANDS and EXOCRINE GLANDS. The small endocrine portion consists of the ISLETS OF LANGERHANS secreting a number of hormones into the blood stream. The large exocrine portion (EXOCRINE PANCREAS) is a compound acinar gland that secretes several digestive enzymes into the pancreatic ductal system that empties into the DUODENUM.
The sum of the weight of all the atoms in a molecule.
Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.
The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
ENDOPEPTIDASES which use a metal such as ZINC in the catalytic mechanism.
Any of various enzymatically catalyzed post-translational modifications of PEPTIDES or PROTEINS in the cell of origin. These modifications include carboxylation; HYDROXYLATION; ACETYLATION; PHOSPHORYLATION; METHYLATION; GLYCOSYLATION; ubiquitination; oxidation; proteolysis; and crosslinking and result in changes in molecular weight and electrophoretic motility.
Proteins obtained from the species SACCHAROMYCES CEREVISIAE. The function of specific proteins from this organism are the subject of intense scientific interest and have been used to derive basic understanding of the functioning similar proteins in higher eukaryotes.
A family of neutral serine proteases with CHYMOTRYPSIN-like activity. Chymases are primarily found in the SECRETORY GRANULES of MAST CELLS and are released during mast cell degranulation.
Hydrolases that specifically cleave the peptide bonds found in PROTEINS and PEPTIDES. Examples of sub-subclasses for this group include EXOPEPTIDASES and ENDOPEPTIDASES.
Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.
An imperfect fungus present on most agricultural seeds and often responsible for the spoilage of seeds in bulk storage. It is also used in the production of fermented food or drink, especially in Japan.
The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.
The extent to which an enzyme retains its structural conformation or its activity when subjected to storage, isolation, and purification or various other physical or chemical manipulations, including proteolytic enzymes and heat.
Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.
The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.
A peptidyl-dipeptidase that catalyzes the release of a C-terminal dipeptide, -Xaa-*-Xbb-Xcc, when neither Xaa nor Xbb is Pro. It is a Cl(-)-dependent, zinc glycoprotein that is generally membrane-bound and active at neutral pH. It may also have endopeptidase activity on some substrates. (From Enzyme Nomenclature, 1992) EC 3.4.15.1.
The degree of similarity between sequences of amino acids. This information is useful for the analyzing genetic relatedness of proteins and species.
A compound produced from succinyl-CoA and GLYCINE as an intermediate in heme synthesis. It is used as a PHOTOCHEMOTHERAPY for actinic KERATOSIS.
Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.
A serine endopeptidase secreted by the pancreas as its zymogen, CHYMOTRYPSINOGEN and carried in the pancreatic juice to the duodenum where it is activated by TRYPSIN. It selectively cleaves aromatic amino acids on the carboxyl side.
Genetically engineered MUTAGENESIS at a specific site in the DNA molecule that introduces a base substitution, or an insertion or deletion.
Cephalosporin antibiotic, partly plasma-bound, that is effective against gram-negative and gram-positive organisms.
A family of SERINE ENDOPEPTIDASES isolated from Bacillus subtilis. EC 3.4.21.-
Proteins prepared by recombinant DNA technology.
Separation technique in which the stationary phase consists of ion exchange resins. The resins contain loosely held small ions that easily exchange places with other small ions of like charge present in solutions washed over the resins.
A glycoside hydrolase found primarily in PLANTS and YEASTS. It has specificity for beta-D-fructofuranosides such as SUCROSE.
Electrophoresis in which a polyacrylamide gel is used as the diffusion medium.
Any member of the group of ENDOPEPTIDASES containing at the active site a serine residue involved in catalysis.
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.
A subclass of EXOPEPTIDASES that act on the free N terminus end of a polypeptide liberating a single amino acid residue. EC 3.4.11.
The scattering of x-rays by matter, especially crystals, with accompanying variation in intensity due to interference effects. Analysis of the crystal structure of materials is performed by passing x-rays through them and registering the diffraction image of the rays (CRYSTALLOGRAPHY, X-RAY). (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
The property of objects that determines the direction of heat flow when they are placed in direct thermal contact. The temperature is the energy of microscopic motions (vibrational and translational) of the particles of atoms.
Granulated cells that are found in almost all tissues, most abundantly in the skin and the gastrointestinal tract. Like the BASOPHILS, mast cells contain large amounts of HISTAMINE and HEPARIN. Unlike basophils, mast cells normally remain in the tissues and do not circulate in the blood. Mast cells, derived from the bone marrow stem cells, are regulated by the STEM CELL FACTOR.
Mercuriphenols substituted with one or more chlorine atoms and one or more nitro groups. Some of these are sulfhydryl reagents which act as chromophoric probes in enzymes and other proteins.
A chromatographic technique that utilizes the ability of biological molecules to bind to certain ligands specifically and reversibly. It is used in protein biochemistry. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
A compound that, on administration, must undergo chemical conversion by metabolic processes before becoming the pharmacologically active drug for which it is a prodrug.
A broad category of proteins involved in the formation, transport and dissolution of TRANSPORT VESICLES. They play a role in the intracellular transport of molecules contained within membrane vesicles. Vesicular transport proteins are distinguished from MEMBRANE TRANSPORT PROTEINS, which move molecules across membranes, by the mode in which the molecules are transported.
The natural enzymatic dissolution of FIBRIN.
Proteins found in any species of fungus.
Peptides composed of between two and twelve amino acids.
A group of alkylating agents derived from mustard gas, with the sulfur replaced by nitrogen. They were formerly used as toxicants and vesicants, but now function as antineoplastic agents. These compounds are also powerful mutagens, teratogens, immunosuppressants, and carcinogens.
A thermostable extracellular metalloendopeptidase containing four calcium ions. (Enzyme Nomenclature, 1992) 3.4.24.27.
A serine endopeptidase that has specificity for cleavage at ARGININE. It cleaves a variety of prohormones including PRO-OPIOMELANOCORTIN, proluteinizing-hormone-releasing hormone, proenkephalins, prodynorphin, and PROINSULIN.
A small, unpaired gland situated in the SELLA TURCICA. It is connected to the HYPOTHALAMUS by a short stalk which is called the INFUNDIBULUM.
Chromatography on non-ionic gels without regard to the mechanism of solute discrimination.
Injuries caused by electric currents. The concept excludes electric burns (BURNS, ELECTRIC), but includes accidental electrocution and electric shock.
An essential aromatic amino acid that is a precursor of MELANIN; DOPAMINE; noradrenalin (NOREPINEPHRINE), and THYROXINE.
The functional hereditary units of FUNGI.
Condensed areas of cellular material that may be bounded by a membrane.
The chemical or biochemical addition of carbohydrate or glycosyl groups to other chemicals, especially peptides or proteins. Glycosyl transferases are used in this biochemical reaction.
A di-isopropyl-fluorophosphate which is an irreversible cholinesterase inhibitor used to investigate the NERVOUS SYSTEM.
A chelating agent that sequesters a variety of polyvalent cations such as CALCIUM. It is used in pharmaceutical manufacturing and as a food additive.
Chloride and mercury-containing derivatives of benzoic acid.
The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.
Precursor of plasmin (FIBRINOLYSIN). It is a single-chain beta-globulin of molecular weight 80-90,000 found mostly in association with fibrinogen in plasma; plasminogen activators change it to fibrinolysin. It is used in wound debriding and has been investigated as a thrombolytic agent.
A stack of flattened vesicles that functions in posttranslational processing and sorting of proteins, receiving them from the rough ENDOPLASMIC RETICULUM and directing them to secretory vesicles, LYSOSOMES, or the CELL MEMBRANE. The movement of proteins takes place by transfer vesicles that bud off from the rough endoplasmic reticulum or Golgi apparatus and fuse with the Golgi, lysosomes or cell membrane. (From Glick, Glossary of Biochemistry and Molecular Biology, 1990)
Conversion of an inactive form of an enzyme to one possessing metabolic activity. It includes 1, activation by ions (activators); 2, activation by cofactors (coenzymes); and 3, conversion of an enzyme precursor (proenzyme or zymogen) to an active enzyme.
Derivatives of SUCCINIC ACID. Included under this heading are a broad variety of acid forms, salts, esters, and amides that contain a 1,4-carboxy terminated aliphatic structure.
The sequential correspondence of nucleotides in one nucleic acid molecule with those of another nucleic acid molecule. Sequence homology is an indication of the genetic relatedness of different organisms and gene function.
An enzyme inhibitor that inactivates IRC-50 arvin, subtilisin, and the fatty acid synthetase complex.
A mitosporic Trichocomaceae fungal genus that develops fruiting organs resembling a broom. When identified, teleomorphs include EUPENICILLIUM and TALAROMYCES. Several species (but especially PENICILLIUM CHRYSOGENUM) are sources of the antibiotic penicillin.
The lipid- and protein-containing, selectively permeable membrane that surrounds the cytoplasm in prokaryotic and eukaryotic cells.
A sub-class of PEPTIDE HYDROLASES that act only near the ends of polypeptide chains.
Cyanogen bromide (CNBr). A compound used in molecular biology to digest some proteins and as a coupling reagent for phosphoroamidate or pyrophosphate internucleotide bonds in DNA duplexes.
A mass spectrometric technique that is used for the analysis of large biomolecules. Analyte molecules are embedded in an excess matrix of small organic molecules that show a high resonant absorption at the laser wavelength used. The matrix absorbs the laser energy, thus inducing a soft disintegration of the sample-matrix mixture into free (gas phase) matrix and analyte molecules and molecular ions. In general, only molecular ions of the analyte molecules are produced, and almost no fragmentation occurs. This makes the method well suited for molecular weight determinations and mixture analysis.
A DNA virus that closely resembles human hepatitis B virus. It has been recovered from naturally infected ducks.
The facilitation of a chemical reaction by material (catalyst) that is not consumed by the reaction.
Single-stranded complementary DNA synthesized from an RNA template by the action of RNA-dependent DNA polymerase. cDNA (i.e., complementary DNA, not circular DNA, not C-DNA) is used in a variety of molecular cloning experiments as well as serving as a specific hybridization probe.
A genus of gram-positive bacteria in the family Thermoactinomycetaceae, that can cause FARMER'S LUNG.
A generic term used to describe a group of polypeptides with related chemical structures and pharmacological properties that are widely distributed in nature. These peptides are AUTACOIDS that act locally to produce pain, vasodilatation, increased vascular permeability, and the synthesis of prostaglandins. Thus, they comprise a subset of the large number of mediators that contribute to the inflammatory response. (From Goodman and Gilman's The Pharmacologic Basis of Therapeutics, 8th ed, p588)
A trace element that is a component of vitamin B12. It has the atomic symbol Co, atomic number 27, and atomic weight 58.93. It is used in nuclear weapons, alloys, and pigments. Deficiency in animals leads to anemia; its excess in humans can lead to erythrocytosis.
A decapeptide bradykinin homolog cleaved from kininogen by kallikreins. It is a smooth-muscle stimulant and hypotensive agent that acts by vasodilatation.
The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.
Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors.
The formation of crystalline substances from solutions or melts. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Serine proteinase inhibitors which inhibit trypsin. They may be endogenous or exogenous compounds.
A zinc containing enzyme of the hydrolase class that catalyzes the removal of the N-terminal amino acid from most L-peptides, particularly those with N-terminal leucine residues but not those with N-terminal lysine or arginine residues. This occurs in tissue cell cytosol, with high activity in the duodenum, liver, and kidney. The activity of this enzyme is commonly assayed using a leucine arylamide chromogenic substrate such as leucyl beta-naphthylamide.
Organic compounds that contain phosphorus as an integral part of the molecule. Included under this heading is broad array of synthetic compounds that are used as PESTICIDES and DRUGS.
One of the endogenous pentapeptides with morphine-like activity. It differs from LEU-ENKEPHALIN by the amino acid METHIONINE in position 5. Its first four amino acid sequence is identical to the tetrapeptide sequence at the N-terminal of BETA-ENDORPHIN.
A 30-kDa protein synthesized primarily in the ANTERIOR PITUITARY GLAND and the HYPOTHALAMUS. It is also found in the skin and other peripheral tissues. Depending on species and tissues, POMC is cleaved by PROHORMONE CONVERTASES yielding various active peptides including ACTH; BETA-LIPOTROPIN; ENDORPHINS; MELANOCYTE-STIMULATING HORMONES; and others (GAMMA-LPH; CORTICOTROPIN-LIKE INTERMEDIATE LOBE PEPTIDE; N-terminal peptide of POMC or NPP).
Compounds consisting of glucosamine and lactate joined by an ether linkage. They occur naturally as N-acetyl derivatives in peptidoglycan, the characteristic polysaccharide composing bacterial cell walls. (From Dorland, 28th ed)
An essential amino acid. It is often added to animal feed.
Positively charged atoms, radicals or groups of atoms with a valence of plus 2, which travel to the cathode or negative pole during electrolysis.
A basic science concerned with the composition, structure, and properties of matter; and the reactions that occur between substances and the associated energy exchange.
Use of restriction endonucleases to analyze and generate a physical map of genomes, genes, or other segments of DNA.
A group of antibiotics that contain 6-aminopenicillanic acid with a side chain attached to the 6-amino group. The penicillin nucleus is the chief structural requirement for biological activity. The side-chain structure determines many of the antibacterial and pharmacological characteristics. (Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1065)
The composition, conformation, and properties of atoms and molecules, and their reaction and interaction processes.
Proteolytic enzymes that are involved in the conversion of protein precursors such as peptide prohormones into PEPTIDE HORMONES. Some are ENDOPEPTIDASES, some are EXOPEPTIDASES.
A product of putrefaction. Poisonous.
Transport proteins that carry specific substances in the blood or across cell membranes.
A pancreatic polypeptide of about 110 amino acids, depending on the species, that is the precursor of insulin. Proinsulin, produced by the PANCREATIC BETA CELLS, is comprised sequentially of the N-terminal B-chain, the proteolytically removable connecting C-peptide, and the C-terminal A-chain. It also contains three disulfide bonds, two between A-chain and B-chain. After cleavage at two locations, insulin and C-peptide are the secreted products. Intact proinsulin with low bioactivity also is secreted in small amounts.
An essential amino acid that is physiologically active in the L-form.
Acyltransferases that use AMINO ACYL TRNA as the amino acid donor in formation of a peptide bond. There are ribosomal and non-ribosomal peptidyltransferases.
Processes involved in the formation of TERTIARY PROTEIN STRUCTURE.
Organelles in CHROMAFFIN CELLS located in the adrenal glands and various other organs. These granules are the site of the synthesis, storage, metabolism, and secretion of EPINEPHRINE and NOREPINEPHRINE.
Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.
Yeast-like ascomycetous fungi of the family Saccharomycetaceae, order SACCHAROMYCETALES isolated from exuded tree sap.
Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).
The study of crystal structure using X-RAY DIFFRACTION techniques. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Antigens on surfaces of cells, including infectious or foreign cells or viruses. They are usually protein-containing groups on cell membranes or walls and may be isolated.
Disruption of the non-covalent bonds and/or disulfide bonds responsible for maintaining the three-dimensional shape and activity of the native protein.
One of the three major families of endogenous opioid peptides. The enkephalins are pentapeptides that are widespread in the central and peripheral nervous systems and in the adrenal medulla.
Derivatives of folic acid (pteroylglutamic acid). In gamma-glutamyl linkage they are found in many tissues. They are converted to folic acid by the action of pteroylpolyglutamate hydrolase or synthesized from folic acid by the action of folate polyglutamate synthetase. Synthetic pteroylpolyglutamic acids, which are in alpha-glutamyl linkage, are active in bacterial growth assays.
Compounds and molecular complexes that consist of very large numbers of atoms and are generally over 500 kDa in size. In biological systems macromolecular substances usually can be visualized using ELECTRON MICROSCOPY and are distinguished from ORGANELLES by the lack of a membrane structure.
EXOPEPTIDASES that specifically act on dipeptides. EC 3.4.13.
The reconstitution of a protein's activity following denaturation.
An analytical method used in determining the identity of a chemical based on its mass using mass analyzers/mass spectrometers.
A 7-carbon keto sugar having the mannose configuration.
A change from planar to elliptic polarization when an initially plane-polarized light wave traverses an optically active medium. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Salts and esters of hippuric acid.
The region of an enzyme that interacts with its substrate to cause the enzymatic reaction.
The smaller fragment generated from the cleavage of complement C3 by C3 CONVERTASE. C3a, a 77-amino acid peptide, is a mediator of local inflammatory process. It induces smooth MUSCLE CONTRACTION, and HISTAMINE RELEASE from MAST CELLS and LEUKOCYTES. C3a is considered an anaphylatoxin along with COMPLEMENT C4A; COMPLEMENT C5A; and COMPLEMENT C5A, DES-ARGININE.
Vesicles derived from the GOLGI APPARATUS containing material to be released at the cell surface.
Neural tissue of the pituitary gland, also known as the neurohypophysis. It consists of the distal AXONS of neurons that produce VASOPRESSIN and OXYTOCIN in the SUPRAOPTIC NUCLEUS and the PARAVENTRICULAR NUCLEUS. These axons travel down through the MEDIAN EMINENCE, the hypothalamic infundibulum of the PITUITARY STALK, to the posterior lobe of the pituitary gland.
A sub-subclass of endopeptidases that depend on an ASPARTIC ACID residue for their activity.
A non-essential amino acid. In animals it is synthesized from PHENYLALANINE. It is also the precursor of EPINEPHRINE; THYROID HORMONES; and melanin.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Chemical groups containing the covalent disulfide bonds -S-S-. The sulfur atoms can be bound to inorganic or organic moieties.
Presence of warmth or heat or a temperature notably higher than an accustomed norm.
Established cell cultures that have the potential to propagate indefinitely.
An essential amino acid that is required for the production of HISTAMINE.
A benign tumor of the pancreatic ISLET CELLS. Usually it involves the INSULIN-producing PANCREATIC BETA CELLS, as in INSULINOMA, resulting in HYPERINSULINISM.
A nonapeptide messenger that is enzymatically produced from KALLIDIN in the blood where it is a potent but short-lived agent of arteriolar dilation and increased capillary permeability. Bradykinin is also released from MAST CELLS during asthma attacks, from gut walls as a gastrointestinal vasodilator, from damaged tissues as a pain signal, and may be a neurotransmitter.
A system of cisternae in the CYTOPLASM of many cells. In places the endoplasmic reticulum is continuous with the plasma membrane (CELL MEMBRANE) or outer membrane of the nuclear envelope. If the outer surfaces of the endoplasmic reticulum membranes are coated with ribosomes, the endoplasmic reticulum is said to be rough-surfaced (ENDOPLASMIC RETICULUM, ROUGH); otherwise it is said to be smooth-surfaced (ENDOPLASMIC RETICULUM, SMOOTH). (King & Stansfield, A Dictionary of Genetics, 4th ed)
An organization of cells into an organ-like structure. Organoids can be generated in culture. They are also found in certain neoplasms.
A product of the lysis of plasminogen (profibrinolysin) by PLASMINOGEN activators. It is composed of two polypeptide chains, light (B) and heavy (A), with a molecular weight of 75,000. It is the major proteolytic enzyme involved in blood clot retraction or the lysis of fibrin and quickly inactivated by antiplasmins.
Enzymes that catalyze the transfer of hexose groups. EC 2.4.1.-.
Electropositive chemical elements characterized by ductility, malleability, luster, and conductance of heat and electricity. They can replace the hydrogen of an acid and form bases with hydroxyl radicals. (Grant & Hackh's Chemical Dictionary, 5th ed)
The intermediate lobe of the pituitary gland. It shows considerable size variation among the species, small in humans, and large in amphibians and lower vertebrates. This lobe produces mainly MELANOCYTE-STIMULATING HORMONES and other peptides from post-translational processing of pro-opiomelanocortin (POMC).
A syndrome characterized by marked limitation of abduction of the eye, variable limitation of adduction and retraction of the globe, and narrowing of the palpebral fissure on attempted adduction. The condition is caused by aberrant innervation of the lateral rectus by fibers of the OCULOMOTOR NERVE.
A plant genus of the family POACEAE that is the source of EDIBLE GRAIN. A hybrid with rye (SECALE CEREALE) is called TRITICALE. The seed is ground into FLOUR and used to make BREAD, and is the source of WHEAT GERM AGGLUTININS.
Recombinant proteins produced by the GENETIC TRANSLATION of fused genes formed by the combination of NUCLEIC ACID REGULATORY SEQUENCES of one or more genes with the protein coding sequences of one or more genes.
Proteins found in any species of bacterium.
The process of moving proteins from one cellular compartment (including extracellular) to another by various sorting and transport mechanisms such as gated transport, protein translocation, and vesicular transport.
A type of ion exchange chromatography using diethylaminoethyl cellulose (DEAE-CELLULOSE) as a positively charged resin. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
The movement of materials (including biochemical substances and drugs) through a biological system at the cellular level. The transport can be across cell membranes and epithelial layers. It also can occur within intracellular compartments and extracellular compartments.
The naturally occurring or experimentally induced replacement of one or more AMINO ACIDS in a protein with another. If a functionally equivalent amino acid is substituted, the protein may retain wild-type activity. Substitution may also diminish, enhance, or eliminate protein function. Experimentally induced substitution is often used to study enzyme activities and binding site properties.
Purifying or cleansing agents, usually salts of long-chain aliphatic bases or acids, that exert cleansing (oil-dissolving) and antimicrobial effects through a surface action that depends on possessing both hydrophilic and hydrophobic properties.
Short sequences (generally about 10 base pairs) of DNA that are complementary to sequences of messenger RNA and allow reverse transcriptases to start copying the adjacent sequences of mRNA. Primers are used extensively in genetic and molecular biology techniques.
The fluid containing digestive enzymes secreted by the pancreas in response to food in the duodenum.
A 150 kDa protein serine-threonine kinase that is found as a regulatory subunit of the class III phosphatidylinositol 3-kinases. The protein is believed to play an important role in the regulation of vesicular trafficking with the cell.
A family of neutral serine proteases with TRYPSIN-like activity. Tryptases are primarily found in the SECRETORY GRANULES of MAST CELLS and are released during mast cell degranulation.
An antiseptic with mild fungistatic, bacteriostatic, anthelmintic, and amebicidal action. It is also used as a reagent and metal chelator, as a carrier for radio-indium for diagnostic purposes, and its halogenated derivatives are used in addition as topical anti-infective agents and oral antiamebics.
An organic amine proton acceptor. It is used in the synthesis of surface-active agents and pharmaceuticals; as an emulsifying agent for cosmetic creams and lotions, mineral oil and paraffin wax emulsions, as a biological buffer, and used as an alkalizer. (From Merck, 11th ed; Martindale, The Extra Pharmacopoeia, 30th ed, p1424)
A decapeptide that is cleaved from precursor angiotensinogen by RENIN. Angiotensin I has limited biological activity. It is converted to angiotensin II, a potent vasoconstrictor, after the removal of two amino acids at the C-terminal by ANGIOTENSIN CONVERTING ENZYME.
A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).
Structurally related forms of an enzyme. Each isoenzyme has the same mechanism and classification, but differs in its chemical, physical, or immunological characteristics.
A potent inhibitor of membrane metalloendopeptidase (ENKEPHALINASE). Thiorphan potentiates morphine-induced ANALGESIA and attenuates naloxone-precipitated withdrawal symptoms.
A non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in the CENTRAL NERVOUS SYSTEM.
Enzyme that is a major constituent of kidney brush-border membranes and is also present to a lesser degree in the brain and other tissues. It preferentially catalyzes cleavage at the amino group of hydrophobic residues of the B-chain of insulin as well as opioid peptides and other biologically active peptides. The enzyme is inhibited primarily by EDTA, phosphoramidon, and thiorphan and is reactivated by zinc. Neprilysin is identical to common acute lymphoblastic leukemia antigen (CALLA Antigen), an important marker in the diagnosis of human acute lymphocytic leukemia. There is no relationship with CALLA PLANT.
Amino acid sequences found in transported proteins that selectively guide the distribution of the proteins to specific cellular compartments.
The level of protein structure in which regular hydrogen-bond interactions within contiguous stretches of polypeptide chain give rise to alpha helices, beta strands (which align to form beta sheets) or other types of coils. This is the first folding level of protein conformation.
A non-essential amino acid that is synthesized from GLUTAMIC ACID. It is an essential component of COLLAGEN and is important for proper functioning of joints and tendons.
Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.
Multicellular, eukaryotic life forms of kingdom Plantae (sensu lato), comprising the VIRIDIPLANTAE; RHODOPHYTA; and GLAUCOPHYTA; all of which acquired chloroplasts by direct endosymbiosis of CYANOBACTERIA. They are characterized by a mainly photosynthetic mode of nutrition; essentially unlimited growth at localized regions of cell divisions (MERISTEMS); cellulose within cells providing rigidity; the absence of organs of locomotion; absence of nervous and sensory systems; and an alternation of haploid and diploid generations.
Organic compounds that contain the (-NH2OH) radical.
Thin structures that encapsulate subcellular structures or ORGANELLES in EUKARYOTIC CELLS. They include a variety of membranes associated with the CELL NUCLEUS; the MITOCHONDRIA; the GOLGI APPARATUS; the ENDOPLASMIC RETICULUM; LYSOSOMES; PLASTIDS; and VACUOLES.
The inner portion of the adrenal gland. Derived from ECTODERM, adrenal medulla consists mainly of CHROMAFFIN CELLS that produces and stores a number of NEUROTRANSMITTERS, mainly adrenaline (EPINEPHRINE) and NOREPINEPHRINE. The activity of the adrenal medulla is regulated by the SYMPATHETIC NERVOUS SYSTEM.
Carboxypeptidase A (left) was the first protein structure from Lipscomb's group. Carboxypeptidase A is a digestive enzyme, a ... Lipscomb, WN; Hartsuck, JA; Reeke, GN Jr; Quiocho, FA; Bethge, PH; Ludwig, ML; Steitz, TA; Muirhead, H; et al. (June 1968). " ... Carboxypeptidase A digests by chopping off certain amino acids one-by-one from one end of a protein. The size of this structure ... "The Structure of Carboxypeptidase A, IV. Prelimitary Results at 2.8 A Resolution, and a Substrate Complex at 6 A Resolution". ...
"Carboxypeptidase". www.chemistry.wustl.edu. Retrieved 2019-03-23. Nelson DL, Cox MM, Lehninger AL (2013). Lehninger principles ... Carboxypeptidases cleave at the carboxyl end of the protein. While they can catabolize proteins, they are more often used in ... These enzymes have two classes: aminopeptidases are a brush border enzyme and carboxypeptidases which is from the pancreas. ...
"Entrez Gene: CPN1 carboxypeptidase N, polypeptide 1". Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets ... Davis DA, Singer KE, De La Luz Sierra M, et al. (2005). "Identification of carboxypeptidase N as an enzyme responsible for C- ... Sato T, Miwa T, Akatsu H, et al. (2000). "Pro-carboxypeptidase R is an acute phase protein in the mouse, whereas ... Hendriks D, Vingron M, Vriend G, et al. (1994). "On the specificity of carboxypeptidase N, a comparative study". Biol. Chem. ...
Bentley L, Nakabayashi K, Monk D, et al. (2003). "The imprinted region on human chromosome 7q32 extends to the carboxypeptidase ... Carboxypeptidase A5 is an enzyme that in humans is encoded by the CPA5 gene. Carboxypeptidases have functions ranging from ... "Entrez Gene: CPA5 carboxypeptidase A5". Human CPA5 genome location and CPA5 gene details page in the UCSC Genome Browser. ... Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The ...
Kayashima T, Yamasaki K, Yamada T, et al. (2003). "The novel imprinted carboxypeptidase A4 gene ( CPA4) in the 7q32 imprinting ... Carboxypeptidase A4 is an enzyme that in humans is encoded by the CPA4 gene. This gene is a member of the carboxypeptidase A/B ... Bentley L, Nakabayashi K, Monk D, et al. (2003). "The imprinted region on human chromosome 7q32 extends to the carboxypeptidase ... Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to ...
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to ... Probable carboxypeptidase X1 is an enzyme that in humans is encoded by the CPXM1 gene. The protein encoded by this gene is a ... "Entrez Gene: CPXM1 carboxypeptidase X (M14 family), member 1". Human CPXM1 genome location and CPXM1 gene details page in the ... Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the ...
"Entrez Gene: CPN2 carboxypeptidase N, polypeptide 2". Human CPN2 genome location and CPN2 gene details page in the UCSC Genome ... Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the ... Carboxypeptidase N subunit 2 is an enzyme that in humans is encoded by the CPN2 gene. GRCh38: Ensembl release 89: ... Skidgel RA, Bennett CD, Schilling JW, et al. (1988). "Amino acid sequence of the N-terminus and selected tryptic peptides of ...
... is an enzyme that is classified both as a cathepsin and a carboxypeptidase. In humans, it is encoded by the CTSA ... van der Horst GT, Kleijer WJ, Hoogeveen AT, et al. (1984). "Morquio B syndrome: a primary defect in beta-galactosidase". Am. J ... Zhou XY, Galjart NJ, Willemsen R, et al. (1992). "A mutation in a mild form of galactosialidosis impairs dimerization of the ... Chitayat D, Applegarth DA, Lewis J, et al. (1989). "Juvenile galactosialidosis in a white male: a new variant". Am. J. Med. ...
Kuba K, Imai Y, Rao S, Gao H, Guo F, Guan B, et al. (August 2005). "A crucial role of angiotensin converting enzyme 2 (ACE2) in ... September 2000). "A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1 ... Xu X, Chen P, Wang J, Feng J, Zhou H, Li X, et al. (March 2020). "Evolution of the novel coronavirus from the ongoing Wuhan ... Zhou P, Yang XL, Wang XG, Hu B, Zhang L, Zhang W, et al. (March 2020). "A pneumonia outbreak associated with a new coronavirus ...
doi:10.1007/s13365-012-0108-z Rahn KA, Watkins CC, Alt J, et al. Inhibition of glutamate carboxypeptidase II (GCPII) activity ... doi:10.1073/pnas.96.6.3059 Watkins CC, Sawa A, Jaffrey S, et al. Insulin restores neuronal nitric oxide synthase expression and ... et al. Poly(ADP-ribose) polymerase-deficient mice are protected from streptozotocin-induced diabetes. Proc Natl Acad Sci U S A ...
Cho et al., 2007). Aagaard et al.: "An inflammatory role for the mammalian carboxypeptidase inhibitor latexin: relationship to ... Arg-Leu-Pro-Ala-Pro-Trp-Ser-Gly-Pro-Arg-Gly-Pro-Arg-Pro-Thr-Ala-Pro-Leu-Leu-Ala-Leu-Leu-Leu-Leu-Leu-Ala-Pro-Val-Ala-Ala-Pro-Ala ... Gln-Gln-Lys-Ala-Arg-Ala-Ala-Leu-His-Phe-Phe-Asn-Phe-Arg-Ser-Gly-Ser-Pro-Ser-Ala-Leu-Arg-Val-Leu-Ala-Glu-Val-Gln-Glu-Gly-Arg-Ala ... Gautron et al.: "Ovacalyxin-32, a novel chicken eggshell matrix protein." J Biol Chem 276(42), 39243-39252, 2001. Jing et al ...
G.A. Cordell (1989). I.W. Southon; et al. (eds.). Dictionary of alkaloids (1. publ. ed.). London: Chapman and Hall. ISBN 0-412- ... a new selective serine carboxypeptidase inhibitor from Streptomyces lavendofoliae MJ908-WF13". Journal of Enzyme Inhibition. 11 ... a new selective serine carboxypeptidase inhibitor from Streptomyces lavendofoliae MJ908-WF13". Journal of Enzyme Inhibition. 11 ...
Fan X, Olson SJ, Blevins LS, et al. (2003). "Immunohistochemical localization of carboxypeptidases D, E, and Z in pituitary ... Carboxypeptidase Z is an enzyme that in humans is encoded by the CPZ gene. This gene encodes a member of the ... "Entrez Gene: CPZ carboxypeptidase Z". Human CPZ genome location and CPZ gene details page in the UCSC Genome Browser. Reznik SE ... This enzyme displays carboxypeptidase activity towards substrates with basic C-terminal residues. It is most active at neutral ...
Zhang P, Chan DW, Zhu Y, et al. (2007). "Identification of carboxypeptidase of glutamate like-B as a candidate suppressor in ... Ghose S, Weickert CS, Colvin SM, et al. (2004). "Glutamate carboxypeptidase II gene expression in the human frontal and ... Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to ... Beta-Ala-His dipeptidase is an enzyme that in humans is encoded by the CNDP1 gene. This gene encodes a member of the M20 ...
Jeffrey KD, Alejandro EU, Luciani DS et al (2008) Carboxypeptidase E mediates palmitate-induced beta-cell ER stress and ... J Cell Sci 121:2308-2318 Oyadomari S, Takeda K, Takiguchi M et al (2001) Nitric oxide-induced apoptosis in pancreatic beta ... Endocr Rev 29:42-61 Laybutt DR, Preston AM, Akerfeldt MC et al (2007) Endoplasmic reticulum stress contributes to beta cell ... Diabetologia 52:2369-2373 Cunha DA, Hekerman P, Ladriere L et al (2008) Initiation and execution of lipotoxic ER stress in ...
Lysosomal Pro-X carboxypeptidase is an enzyme that in humans is encoded by the PRCP gene. The protein encoded by this gene is a ... Watson B, Nowak NJ, Myracle AD, et al. (1997). "The human angiotensinase C gene (HUMPCP) maps to 11q14 within 700 kb of D11S901 ... Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The ... Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human ...
Riesewijk AM, Blagitko N, Schinzel AA, Hu L, Schulz U, Hamel BC, et al. (1998). "Evidence against a major role of PEG1/MEST in ... 2003). "The imprinted region on human chromosome 7q32 extends to the carboxypeptidase A gene cluster: an imprinted candidate ... Kobayashi S, Uemura H, Kohda T, Nagai T, Chinen Y, Naritomi K, et al. (2001). "No evidence of PEG1/MEST gene mutations in ... Yamada T, Mitsuya K, Kayashima T, Yamasaki K, Ohta T, Yoshiura K, et al. (2004). "Imprinting analysis of 10 genes and/or ...
Sommaruga et al.(2014) also improved the stability and reaction yield of a well-characterized carboxypeptidase from S. ... Frols et al. and Ajon et al. hypothesized that the UV-inducible DNA transfer process and subsequent homologous recombinational ... Ajon et al. showed that UV-induced cellular aggregation mediates chromosomal marker exchange with high frequency. Recombination ... Fröls S, Ajon M, Wagner M, Teichmann D, Zolghadr B, Folea M, et al. (November 2008). "UV-inducible cellular aggregation of the ...
Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton ... Retinoid-inducible serine carboxypeptidase is an enzyme that in humans is encoded by the SCPEP1 gene. GRCh38: Ensembl release ... Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the ... Chen J, Streb JW, Maltby KM, Kitchen CM, Miano JM (Sep 2001). "Cloning of a novel retinoid-inducible serine carboxypeptidase ...
Shown in the picture below is the proposed model for the active site of LAP-A in tomato based on the work of Strater et al. It ... the mechanisms of carboxypeptidases and endoprotease have been much more well-studied and understood by researchers (Ref #6 ... The Gu et al. from 1999 demonstrated that six 55kDA enzymatically inactive LAP-A protomers come together to form the 353kDa ... LAP-A), a product of the octadecanoid pathway in some solanaceous plants, has been shown by Fowler et al. to have a regulatory ...
Pereira PJ, Wang ZM, Rubin H, et al. (1999). "The 2.2 A crystal structure of human chymase in complex with succinyl-Ala-Ala-Pro ... chloromethylketone: structural explanation for its dipeptidyl carboxypeptidase specificity". J. Mol. Biol. 286 (1): 163-73. doi ... Pereira PJ, Wang ZM, Rubin H, et al. (1999). "The 2.2 A Crystal Structure of Human Chymase in Complex with Succinyl-Ala-Ala-Pro ... Urata H, Kinoshita A, Perez DM, et al. (1991). "Cloning of the gene and cDNA for human heart chymase". J. Biol. Chem. 266 (26 ...
M.S.et al. Lysianadioic acid, a carboxypeptidase B inhibitor from Lysiana subfalcata Bio-organic & Medicinal Chemistry Letters ... was a carboxypeptidase B (CPB) inhibitor. It is a potent inhibitor of CPB with an IC50 of 0.36 lM. This is the first known ...
It has also been found to affect the activity of carboxypeptidase H and phenylmethylsulfonylfluoride-inhibited carboxypeptidase ... Kost NV; Sokolov OIu; Gabaeva MV; et al. (2001). "Semax and selank inhibit the enkephalin-degrading enzymes from human serum". ... Solov'ev VB, Gengin MT, Sollertinskaia TN, Latynova IV, Zhivaeva LV (2012). "[Effect of selank on the main carboxypeptidases in ...
... may refer to: Muramoylpentapeptide carboxypeptidase, an enzyme Serine-type D-Ala-D-Ala carboxypeptidase, an enzyme ...
Lai et al. studied the effects of dynorphin A2-13 that did not contain the N-terminal tyrosine. Based on the results of ... Cleavage at single basic residues and enhanced processing in the presence of carboxypeptidase activity". J. Biol. Chem. 273 (2 ... Shirayama et al. used several animal depression models in rats to describe the effects of dynorphins A and B in depression. The ... Berman et al. studied the levels of dynorphin during periods of food restriction. The group found that while food did not alter ...
This enzyme catalyses the following chemical reaction Cleavage of the C-terminal propeptide at Ala-Asp in type I and II ... procollagen carboxypeptidase, procollagen carboxy-terminal proteinase, procollagen peptidase) is an enzyme. ...
... carboxypeptidase U MeSH D08.811.277.656.350.245.252 - Serine-type D-Ala-D-Ala carboxypeptidase MeSH D08.811.277.656.350.245.280 ... carboxypeptidase B MeSH D08.811.277.656.350.245.111 - carboxypeptidase C MeSH D08.811.277.656.350.245.167 - carboxypeptidase H ... carboxypeptidase b MeSH D08.811.277.656.350.555.250 - carboxypeptidase h MeSH D08.811.277.656.350.555.300 - carboxypeptidase u ... carboxypeptidase b MeSH D08.811.277.656.675.555.250 - carboxypeptidase h MeSH D08.811.277.656.675.555.300 - carboxypeptidase u ...
D-alanine carboxypeptidase, D-alanyl carboxypeptidase, and serine-type D-Ala-D-Ala carboxypeptidase.) is a bacterial enzyme ... The MEROPS online database for peptidases and their inhibitors: S11.001 EC 3.4.16.4 Serine-Type+D-Ala-D-Ala+Carboxypeptidase at ... "E.C.3.4.16.4 Serine-type D-Ala-D-Ala carboxypeptidase". Enzyme Structures Database. Archived from the original on May 17, 2006 ... Penicillin is a cyclic analogue of the D-Ala-D-Ala terminated carbonyl donors, therefore in the presence of this antibiotic, ...
In 1989, Tamura et al. found that, by themselves, basic residues such as Lys-Gly and Lys-Lys produced sour and salty tastes in ... who carried out the experiment using the Edman degradation method for N-terminus sequencing and carboxypeptidase A (Cpase A) ... Lys-Gly-Asp-Glu-Glu-Ser-Leu-Ala The primary structure was first determined by Yamasaki and Maekawa, ... Lys-Gly-Asp-Glu-Glu-Ser-Leu-Ala) from beef soup". Agricultural and Biological Chemistry. 53 (2): 319-325. doi:10.1271/ ...
"Carboxypeptidase". www.chemistry.wustl.edu. Retrieved 2019-03-23.. *^ Nelson DL, Cox MM, Lehninger AL (2013). Lehninger ... Carboxypeptidases cleave at the carboxyl end of the protein. While they can catabolize proteins, they are more often used in ... aminopeptidases and carboxypeptidases. Aminopeptidases are enzymes that remove amino acids from the amino terminus of protein. ...
"Binding of D-phenylalanine and D-tyrosine to carboxypeptidase A." Journal of Biological Chemistry 1989 Aug 5;264(22):12849-53. ... Dawson, R.M.C., et al., Data for Biochemical Research, Oxford, Clarendon Press, 1959. ...
Pervasive and required for several enzymes such as carboxypeptidase, liver alcohol dehydrogenase, and carbonic anhydrase ... Authors: Nielsen, Forrest H. USDA, ARS Source: Modern nutrition in health and disease / editors, Maurice E. Shils ... et al.. ...
It binds carboxypeptidase E (CPE), and the disruption of this binding has been proposed to cause the loss of sorting of BDNF ... Mandel AL, Ozdener H, Utermohlen V (July 2009). "Identification of pro- and mature brain-derived neurotrophic factor in human ... Willer CJ, Speliotes EK, Loos RJ, Li S, Lindgren CM, Heid IM, et al. (January 2009). "Six new loci associated with body mass ... Jiang X, Tian F, Du Y, Copeland NG, Jenkins NA, Tessarollo L, et al. (January 2008). "BHLHB2 controls Bdnf promoter 4 activity ...
Eifler J. B.; Feng Z.; Lin B. M.; Partin M. T.; Humphreys E. B.; Han M.; Epstein J. I.; Walsh P. C.; Trock B. J.; et al. (2013 ... Prostate specific membrane antigen is a transmembrane carboxypeptidase and exhibits folate hydrolase activity.[75] This protein ... Potosky AL, Miller BA, Albertsen PC, Kramer BS (February 1995). "The role of increasing detection in the rising incidence of ... Lozano R, Naghavi M, Foreman K, Lim S, Shibuya K, Aboyans V, Abraham J, Adair T, Aggarwal R, Ahn SY, et al. (Dec 15, 2012). " ...
Shils, M.S.; et al., eds. (2005). Modern Nutrition in Health and Disease. Lippincott Williams and Wilkins. ISBN 978-0781741330. ... Zinc required for several enzymes such as carboxypeptidase, liver alcohol dehydrogenase, and carbonic anhydrase ... Armstrong LE, Pumerantz AC, Roti MW, Judelson DA, Watson G, Dias JC, Sokmen B, Casa DJ, Maresh CM, et al. (2005). "Fluid, ... Baldi, S. (ED.) et al. (2009). Technical Report and Data File User's Manual for the 2003 National Assessment of Adult Literacy ...
a b c d Murphy K, Travers P, Walport M, with contributions by Ehrenstein M et al. (2008). Janeway's Immunobiology (7th ed.), ... and is usually rapidly cleaved by carboxypeptidase B. Both C3a and C5a have anaphylatoxin activity, directly triggering ... DeFranco AL, Locksley RM, Robertson M (2007). Immunity : The Immune Response in Infectious and Inflammatory Disease. London; ... CS1 maint: Explicit use of et al. (link). *^ Datta, P.K.; Rappaport, J. (2006). "HIV and complement: Hijacking an immune ...
Coux O, Tanaka K, Goldberg AL (1996). "Structure and functions of the 20S and 26S proteasomes". Annual Review of Biochemistry. ... Serine type carboxypeptidases: Cathepsin A. *DD-transpeptidase. 3.4.17. Metalloexopeptidases. Carboxypeptidase A. A2. B. C. E. ...
a b c d e f g h i j k l m n o p q r s t u v w x y z aa ab ac ad ae af ag ah ai aj ak al am an ao ap aq ar as at au av aw ax ay ... Zinc required for several enzymes such as carboxypeptidase, liver alcohol dehydrogenase, carbonic anhydrase ... Polhamus B, et al. (2004). "Pediatric Nutrition Surveillance 2003 Report, Table 18D" (PDF). U.S. Department of Health and Human ... Villa P, Bouville C, Courtin J, Helmer D, Mahieu E, Shipman P, et al. (July 1986). "Cannibalism in the neolithic". Science. 233 ...
Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton ... carboxypeptidase activity. • hydrolase activity. • metallopeptidase activity. • metallocarboxypeptidase activity. • ... Cloning and functional expression as a captopril-insensitive carboxypeptidase". The Journal of Biological Chemistry. 275 (43): ... "Hydrolysis of biological peptides by human angiotensin-converting enzyme-related carboxypeptidase". The Journal of Biological ...
Kuba K, Imai Y, Rao S, Gao H, Guo F, Guan B, et al. (August 2005). "A crucial role of angiotensin converting enzyme 2 (ACE2) in ... September 2000). "A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1 ... Xu X, Chen P, Wang J, Feng J, Zhou H, Li X, et al. (March 2020). "Evolution of the novel coronavirus from the ongoing Wuhan ... Zhou P, Yang XL, Wang XG, Hu B, Zhang L, Zhang W, et al. (March 2020). "A pneumonia outbreak associated with a new coronavirus ...
Pelc LA, Chen Z, Gohara DW, et al. (2015). "Why Ser and not Thr brokers catalysis in the trypsin fold". Biochemistry. 54 (7): ... Murein tetrapeptidase LD-carboxypeptidase (Pseudomonas aeruginosa) ST. S54. Rhomboid-1 (Drosophila melanogaster) ... Sun Y, Yin S, Feng Y, et al. (2014). "Molecular basis of the general base catalysis of an α/β-hydrolase catalytic triad". J. ... Mao S, Dong Z, Liu J, et al. (2005). "Semisynthetic tellurosubtilisin with glutathione peroxidase activity". J. Am. Chem. Soc. ...
Anker SD, Ponikowski P, Varney S, Chua TP, Clark AL, Webb-Peploe KM, Harrington D, Kox WJ, Poole-Wilson PA, Coats AJ (1997). " ... David Cushman, Miguel Ondetti and colleagues used peptide analogues to study the structure of ACE, using carboxypeptidase A as ...
Gibbs, R. A.; et al. (2007). "Evolutionary and Biomedical Insights from the Rhesus Macaque Genome" (pdf). Science 316 (5822): ... "Binding of D-Phenylalanine and D-Tyrosine to Carboxypeptidase A" (pdf). Journal of Biological Chemistry 264 (22): 12849-12853 ... Dawson, R. M. C.; et al. (1959). Data for Biochemical Research. Oxford: Clarendon Press.. ... Mortell KH, Anderson DJ, Lynch JJ, et al. (March 2006). "Structure-activity relationships of alpha-amino acid ligands for the ...
Al-Abdallah Q, Brakhage AA, Gehrke A, Plattner H, Sprote P, Tuncher A (2004). "Regulation of Penicillin Biosynthesis in ... Penicillin acylates the active site of Bacillus stearothermophilus D-alanine carboxypeptidase". The Journal of Biological ... Model of Structure of Penicillin, by Dorothy Hodgkin et al., Museum of the History of Science, Oxford ...
Barbara Mühlemann et al. (9 May 2018). "Ancient hepatitis B viruses from the Bronze Age to the Medieval period". Nature. doi: ... There is evidence that the receptor in the closely related duck hepatitis B virus is carboxypeptidase D.[53][54] The virions ... Zuckerman AJ (1996). "Hepatitis Viruses". In Baron S; et al. Baron's Medical Microbiology (4th ed.). University of Texas ... help)CS1 maint: Uses authors parameter (link) CS1 maint: Explicit use of et al. (link) ...
Meija, J.; et al. (2016). "Atomic weights of the elements 2013 (IUPAC Technical Report)". Pure and Applied Chemistry. 88 (3): ... Carboxypeptidase cleaves peptide linkages during digestion of proteins. A coordinate covalent bond is formed between the ... Gerhartz, Wolfgang; et al. (1996). Ullmann's Encyclopedia of Industrial Chemistry (5th ed.). VHC. p. 509. ISBN 3-527-20100-9.. ... 1996). S. Demirci; et al., eds. A Roman zinc tablet from Bern, Switzerland: Reconstruction of the Manufacture. Archaeometry 94 ...
Westermark P, Wernstedt C, Wilander E, et al. (1987). "Amyloid fibrils in human insulinoma and islets of Langerhans of the ... Marzban L, Soukhatcheva G, Verchere CB (April 2005). "Role of carboxypeptidase E in processing of pro-islet amyloid polypeptide ... Cooper GJ, Willis AC, Clark A, et al. (1988). "Purification and characterization of a peptide from amyloid-rich pancreases of ... Butler PC, Chou J, Carter WB, et al. (1990). "Effects of meal ingestion on plasma amylin concentration in NIDDM and nondiabetic ...
... (EC 3.4.17.14, Zn2+ G peptidase, D-alanyl-D-alanine hydrolase, D-alanyl-D-alanine-cleaving ... Zinc D-Ala-D-Ala carboxypeptidase at the US National Library of Medicine Medical Subject Headings (MeSH) Molecular and Cellular ... carboxypeptidase, DD-carboxypeptidase, G enzyme, DD-carboxypeptidase-transpeptidase) is an enzyme. This enzyme catalyses the ... "The complete amino acid sequence of the Zn2+-containing D-alanyl-D-alanine-cleaving carboxypeptidase of Streptomyces albus G". ...
Carboxypeptidase, which is a pancreatic brush border enzyme, splits one amino acid at a time. Aminopeptidase and dipeptidase ... and has a mean length of 5 metres (3 - 8.5 metres) when measured intraoperatively in the living adult (Tietelbaum et al 2013). ... Solomon et al. (2002) Biology Sixth Edition, Brooks-Cole/Thomson Learning ISBN 0-03-033503-5 ... Townsend et al. (2004) Sabiston Textbook of Surgery, Elsevier ISBN 0-7216-0409-9 ...
Al3+. Cr3+. Hydrated Ion [Fe(H2O)6]2+ Pale green. Solution [Fe(H2O)6]3+ Yellow/brown. Solution [Co(H2O)6]2+. Pink. Solution [Cu ... and carboxypeptidase, a hydrolytic enzyme important in digestion. Another complex ion enzyme is catalase, which decomposes the ... Al(H2O)3(OH)3]. White. Precipitate [Cr(H2O)3(OH)3]. Green. Precipitate ... Al(H2O)6]3+. Colourless. Solution [Cr(H2O)6]3+. Green. Solution ... Al(NH3)3]3+. White. Precipitate [Cr(NH3)6]3+. Purple. Solution ...
21 (FVII · FIX · FX · FXI · FXII · FD · PROC · Trombin) · .22 · .23 · .24 (.1 ALA · .7 MMP-1 · .17 MMP-3/MMP-6 · .19 BMP-1 · . ... procollagen carboxypeptidase; procollagen carboxy-terminal proteinase; procollagen peptidase, BMP-1, EC 3.4.24.19) merupakan ... enzim metaloprotease yang mengiris terminus-C pada posisi Ala-Asp pada prokolagen tipe I dan II, dan pada posisi arg-Asp pada ...
1 2 3 Donoghue M., Hsieh F., Baronas E., Godbout K., Gosselin M., Stagliano N et al. A novel angiotensin-converting enzyme- ... carboxypeptidase activity. • гидролазная активность. • metallopeptidase activity. • metallocarboxypeptidase activity. • ... 1 2 Vickers C., Hales P., Kaushik V., Dick L., Gavin J., Tang J et al. Hydrolysis of biological peptides by human angiotensin- ... Lambert D. W., Yarski M., Warner F. J., Thornhill P., Parkin E. T., Smith AI et al. Tumor necrosis factor-alpha convertase ( ...
Daily dosing during 2 weeks, reduced BACE1 activity by 50-75% and CSF Aβ42 by 72% (Willis et al., 2012; Bowman Rogers and ... Serine type carboxypeptidases: Cathepsin A. *DD-transpeptidase. 3.4.17. .mw-parser-output .nobold{font-weight:normal}. ... Biere AL, Curran E, Burgess T, Louis JC, Collins F, Treanor J, Rogers G, Citron M (Oct 1999). "Beta-secretase cleavage of ...
Rojas R, van Vlijmen T, Mardones GA, Prabhu Y, Rojas AL, Mohammed S, Heck AJ, Raposo G, van der Sluijs P, Bonifacino JS (Nov ... Early study on sorting of acid hydrolases such as carboxypeptidase Y (CPY) in S. cerevisiae mutants has led to the ...
A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9». Circulation ...
Galagan JE, et al. (December 2005). "Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. ... Enzymes: strong secretion of amylases (α-amylase and glucoamylase); some carboxypeptidase; low tyrosinase ... Machida, Masayuki; et al. (December 2005). "Genome sequencing and analysis of Aspergillus oryzae". Nature. 438 (7071): 1157- ...
Although the tubulin carboxypeptidase has yet to be identified, the tubulin-tyrosine ligase (TTL) is known. Delta2: the removal ... Alberts B, Johnson A, Lewis J, et al. Molecular Biology of the Cell. 4th edition. New York: Garland Science; 2002. The Self- ... Bakhoum SF, Thompson SL, Manning AL, Compton DA (January 2009). "Genome stability is ensured by temporal control of kinetochore ...
291-296) (Maslowska et al. 1999, pp. 679-686) (Koistinen et al. 2001, pp. 1034-1039) (Cianflone et al. 1997, pp. 1239-1244) ... In the human body, C3a is rapidly cleaved by carboxypeptidase B or carbxyopeptidase N, that remove the carboxyl-terminal ... Baldo et al. 1993, pp. 1543-1547) (Cianflone et al., pp. 426-430) (Sniderman, Maslowska & Cianflone 2000, pp. ... harv error: no target: CITEREFCianfloneZhangGenest_JrSniderman1997 (help) (Cui et al. 2009, pp. 3207-3217) harv error: no ...
Zinc D-Ala-D-Ala carboxypeptidase (EC 3.4.17.14, Zn2+ G peptidase, D-alanyl-D-alanine hydrolase, D-alanyl-D-alanine-cleaving ... Zinc+D-Ala-D-Ala+carboxypeptidase at the US National Library of Medicine Medical Subject Headings (MeSH) Biology portal. ... carboxypeptidase, DD-carboxypeptidase, G enzyme, DD-carboxypeptidase-transpeptidase) is an enzyme. This enzyme catalyses the ... "The complete amino acid sequence of the Zn2+-containing D-alanyl-D-alanine-cleaving carboxypeptidase of streptomyces albus G". ...
D-alanine carboxypeptidase; DD-carboxypeptidase; D-alanyl carboxypeptidase ... Preferential cleavage: (Ac)2-L-Lys-D-Ala┼D-Ala. Also transpeptidation of peptidyl-alanyl moieties that are N-acyl substituents ... DD-peptidase; D-alanyl-D-alanine-carboxypeptidase; D-alanyl-D-alanine-cleaving-peptidase; D-alanyl-D-alanine-cleaving peptidase ... serine-type D-Ala-D-Ala carboxypeptidase. serine-type D-Ala-D-Ala carboxypeptidase. ...
Carboxypeptidase A (left) was the first protein structure from Lipscombs group. Carboxypeptidase A is a digestive enzyme, a ... Lipscomb, WN; Hartsuck, JA; Reeke, GN Jr; Quiocho, FA; Bethge, PH; Ludwig, ML; Steitz, TA; Muirhead, H; et al. (June 1968). " ... Carboxypeptidase A digests by chopping off certain amino acids one-by-one from one end of a protein. The size of this structure ... "The Structure of Carboxypeptidase A, IV. Prelimitary Results at 2.8 A Resolution, and a Substrate Complex at 6 A Resolution". ...
Preferential cleavage: Ac2-L-Lys-D-Ala-,-D-Ala. Also transpeptidation of peptidyl-alanyl moieties that are N-acyl substituents ... See also Velankar et al., Nucleic Acids Research 33, D262-265 (2005). ...
Redlitz et al. (30) showed that a potato carboxypeptidase inhibitor-sensitive (PCI-sensitive) activity (PCI inhibits pCPB but ... Characterization of a carboxypeptidase in human serum distinct from carboxypeptidase N. J Clin Chem Clin Biochem 1989. 27:277- ... Carboxypeptidase U, a plasma carboxypeptidase with high affinity for plasminogen. J Biol Chem 1994. 269:15937-15944. View this ... Menell, JS, et al. Annexin II and bleeding in acute promyelocytic leukemia. N Engl J Med 1999. 340:994-1004. View this article ...
Naggert et al., 1995;Fricker et al., 1996; Rovere et al., 1996; Cain et al., 1997; Lacourse et al., 1997, 1998; Udupi et al., ... Mendel et al., 1995; Segalat et al., 1995; Brundage et al., 1996; Korswagen et al., 1997; Roayaie et al., 1998; Jansen et al., ... Duret et al., 1998; Gregoire et al., 1998; Li et al., 1999b; Kawano et al., 2000; Pierce et al., 2001). This could be an ... Naggert et al., 1995; Fricker et al., 1996) and E300 (Qian et al., 1999), are conserved in EGL-21 (Fig.1B). Mammalian CPEs are ...
Lee et al. [7] reported that reconstituted HDL particles containing apoA-I were cleaved either at the N-terminus (Tyr18 or Phe ... carboxypeptidase A, cardiovascular disease, chymase, mass spectrometry, mast cell, truncated apolipoprotein A-I ... Identification of sites in apolipoprotein A-I susceptible to chymase and carboxypeptidase A digestion Yoko Usami Yoko Usami ... However, Lee et al. [7] used both recombinant human chymase and rat chymase (MC granule remnants). On the basis of previous ...
Serine-type D-ala-d-ala Carboxypeptidase. A carboxypeptidase that is specific for proteins that contain two ALANINE residues on ... Carboxypeptidase B. A ZINC-dependent carboxypeptidase primary found in the DIGESTIVE SYSTEM. The enzyme catalyzes the ... Home » Topics » Enzymes » Research » The D-alanyl-d-alanine carboxypeptidase enzyme is essential for virulence in the Schu S4 ... Pro-carboxypeptidase U in human plasma is activated by thrombin or plasmin during clotting to form the unstable ...
serine-type D-Ala-D-Ala carboxypeptidase activity Source: InterPro. Complete GO annotation on QuickGO ... ... CarboxypeptidaseImported. ,p>Information which has been imported from another database using automatic procedures.,/p> ,p>,a ... tr,A0A2N0U7E6,A0A2N0U7E6_AERHY D-alanyl-D-alanine carboxypeptidase OS=Aeromonas hydrophila OX=644 GN=AHGSH82_010320 PE=3 SV=1 ... D-alanyl-D-alanine carboxypeptidaseImported. Automatic assertion inferred from database entriesi ...
C51 family D-Ala-D-Gly carboxypeptidase. Cell wall hydrolase. 85. (24). ... Arndt D, Grant JR, Marcu A, Sajed T, Pon A, Liang Y, et al. PHASTER: a better, faster version of the PHAST phage search tool. ... King NP, Beatson SA, Totsika M, Ulett GC, Alm RA, Manning PA, et al. UafB is a serine-rich repeat adhesin of Staphylococcus ... González-García S, Belo S, Dias AC, Rodrigues JV, Da Costa RR, Ferreira A, et al. Life cycle assessment of pigmeat production: ...
Uyanik et al. (2001) and Karamouzet al. (2010) showed that zinc supplementation had no significant effect on serum alkaline ... pancreatic carboxypeptidase A; and liver nuclear DNA dependent RNA-polymerase may be depressed. Many authors have suggested ... Wedekind et al., 1992). Sandoval et al. (1998) reported that ZnO was about 60% available compared with reagent-grade ZnSO4 and ... Balas et al., 1994). Fetal abnormalities occur and hatchability of eggs is reduced (Bao et al., 2007;Golden, 1988). Zinc ...
Peptidase S11, D-Ala-D-Ala carboxypeptidase A, C-terminal (IPR012907). *Penicillin-binding protein 4, C-terminal domain ( ... as well as at the C-terminal of D-Ala-D-Ala carboxypeptidase A, a member of the MEROPS S11 peptidase family (PBP4 and PBP5 also ...
Rattu, M. et al. Glucarpidase (Voraxaze), a Carboxypeptidase Enzyme for Methotrexate Toxicity ... Weber, J et al. Reaffirming and Clarifying the American Society of Clinical Oncologys Policy Statement on the Critical Role of ...
Analysis of the three-dimensional structure of ACE shows that it bears little similarity to that of carboxypeptidase A, but ... but were instead designed on the basis of an assumed mechanistic homology with carboxypeptidase A1. Here we present the X-ray ... Arndt, J. W. et al. Crystal structure of a novel carboxypeptidase from the hyperthermophilic archaeon Pyrococcus furiosus. ... Junot, C. et al. RXP 407, a selective inhibitor of the N-domain of angiotensin I-converting enzyme, blocks in vivo the ...
Mathews, K.P., et al., Familial carboxypeptidase N deficiency. Ann Intern Med, 1980. 93(3): p. 443-5. ... Warner et al, found that 32% of patients with angioedema due to an ARB had a prior episode of angioedema attributed to an ACE ... Lombardi, C., et al., Are physicians aware of the side effects of angiotensin-converting enzyme inhibitors?: a questionnaire ... Ishoo, E., et al., Predicting airway risk in angioedema: staging system based on presentation. Otolaryngol Head Neck Surg, 1999 ...
Osterman AL, Grishin NV, Smulevitch SV, Matz MV, Zagnitko OP, Revina LP, Stepanov VM. Primary structure of carboxypeptidase T: ... This entry represents the carboxypeptidase domain found in carboxypeptidase (CP) E (CPE, also known as carboxypeptidase H, and ... The carboxypeptidase A family can be divided into four subfamilies: M14A (carboxypeptidase A or digestive), M14B ( ... Carboxypeptidase E in the mouse placenta.. Differentiation 74 648-60 2006. Rawlings ND, Barrett AJ. Evolutionary families of ...
Cathepsin A is an enzyme that is classified both as a cathepsin and a carboxypeptidase. In humans, it is encoded by the CTSA ... Chitayat D, Applegarth DA, Lewis J, et al. (1989). "Juvenile galactosialidosis in a white male: a new variant". Am. J. Med. ... carboxypeptidase activity. • enzyme activator activity. • hydrolase activity. • exo-alpha-sialidase activity. • serine-type ... van der Horst GT, Kleijer WJ, Hoogeveen AT, et al. (1984). "Morquio B syndrome: a primary defect in beta-galactosidase". Am. J ...
Serine-type D-Ala-D-Ala carboxypeptidase. STRPM. 410. Serine-type D-Ala-D-Ala carboxypeptidase. Streptococcus pyogenes GA06023 ... Serine-type D-Ala-D-Ala carboxypeptidase. STRPO. 412. UniRef50_A0A4U9ZLU4. Serine-type D-Ala-D-Ala carboxypeptidase. STRPY ...
Serine-Type D-Ala-D-Ala Carboxypeptidase Grant support * 101824/Wellcome Trust/United Kingdom ...
Me Sung Y, Dakshanamurthy S, Ji Y, Kumar D, et al. Tumor suppressor RARRES1 interacts with cytoplasmic carboxypeptidase AGBL2 ... et al.. A first-in-human study of the dual ROCK I/II inhibitor, AT13148, in patients with advanced cancers. J Clin Oncol 2015; ... et al.. Accuracy of 3D volumetric image registration based on CT, MR and PET/CT phantom experiments. J Appl Clin Med Phys 2008; ... et al.. Acetylated tubulin (AT) as a prognostic marker in squamous cell carcinoma of the head and neck. Head Neck Pathol 2014;8 ...
Family M14: carboxypeptidase A family Family M15: zinc D-Ala-D-Ala carboxypeptidase family ...
Barinka C, Byun Y, Dusich CL, Banerjee SR, Chen Y, Castanares M, et al. Interactions between human glutamate carboxypeptidase ... Afshar-Oromieh A, Avtzi E, Giesel FL, Holland-Letz T, Linhart HG, Eder M, et al. The diagnostic value of PET/CT imaging with ... Rowe SP, Gage KL, Faraj SF, Macura KJ, Cornish TC, Gonzalez-Roibon N, et al. 18F-DCFBC PET/CT for PSMA-based detection and ... Dietlein M, Kobe C, Kuhnert G, Stockter S, Fischer T, Schomäcker K, et al. Comparison of [18F]DCFPyL and [68Ga]Ga-PSMA-HBED-CC ...
1 2 3 Donoghue M., Hsieh F., Baronas E., Godbout K., Gosselin M., Stagliano N et al. A novel angiotensin-converting enzyme- ... carboxypeptidase activity. • гидролазная активность. • metallopeptidase activity. • metallocarboxypeptidase activity. • ... 1 2 Vickers C., Hales P., Kaushik V., Dick L., Gavin J., Tang J et al. Hydrolysis of biological peptides by human angiotensin- ... Lambert D. W., Yarski M., Warner F. J., Thornhill P., Parkin E. T., Smith AI et al. Tumor necrosis factor-alpha convertase ( ...
Donoghue M, Hsieh F, Baronas E, et al. A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts ... Berlaimont V, Billiouw JM, Brohet C, et al. Lessons from ONTARGET. Acta Clin Belg. 2008;63:142-151.PubMedGoogle Scholar ... Rice GI, Jones AL, Grant PJ, Carter AM, Turner AJ, Hooper NM. Circulating activities of angiotensin-converting enzyme, its ... Santos RA, Simoes E Silva AC, Maric C, et al. Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas ...
PESSOA, L. G. ; BAPTISTA, H. A. ; BADER, M. ; PAIVA, A. C. M. ; PESQUERO, Jo o Bosco . Human carboxypeptidase M gene and ... papel da ponte dissulfeto Cys18-Cys-274 e da terceira al a extracelular.. In: XX Reuni o Anual da FESBE, 2005, guas de Lind ia ... Molecular structure and alternative splicing of the human carboxypeptidase M gene. Biological Chemistry. , v. 383, p. 263-269, ... Molecular structure and alternative splicing of the human carboxypeptidase M gene. In: An International Multidisciplinary ...
... zinc D-Ala-D-Ala carboxypeptidase [EC:3.4.17.14] K02491 kinA; two-component system, sporulation sensor kinase A [EC:2.7.13.3] ...
Kayashima T, Yamasaki K, Yamada T, Sakai H, Miwa N, Ohta T. et al. The novel imprinted carboxypeptidase A4 gene ( CPA4) in the ... 5. Ross PL, Cheng I, Liu X, Cicek MS, Carroll PR, Casey G. et al. Carboxypeptidase 4 gene variants and early-onset intermediate ... et al. Mcm2, Geminin, and KI67 define proliferative state and are prognostic markers in renal cell carcinoma. Clin Cancer Res. ... et al. Altered Expression of Imprinted Genes in Squamous Cell Carcinoma of the Head and Neck. Anticancer research. 2016;36:2251 ...
Mouse Monoclonal Anti-Carboxypeptidase A1/CPA1 Antibody (OTI2A3). Validated: WB, ICC/IF, IHC, IHC-P. Tested Reactivity: Human. ... Villani V, Thornton ME, Zook HN et al. SOX9+/PTF1A+ Cells Define the Tip Progenitor Cells of the Human Fetal Pancreas of the ... Home » Carboxypeptidase A1/CPA1 » Carboxypeptidase A1/CPA1 Antibodies » Carboxypeptidase A1/CPA1 Antibody (OTI2A3) ... Blogs on Carboxypeptidase A1/CPA1. There are no specific blogs for Carboxypeptidase A1/CPA1, but you can read our latest blog ...
Donoghue, M., et al. 2000. A novel ACE-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin1-9. Circ. Res. 87: ... Vickers, C., et al. 2002. Hydrolysis of biological peptides by human angiotensin-converting enzyme-related carboxypeptidase. J ... Ito, M., et al. 1995. Regulation of blood pressure by the type IA receptor for angiotensin II. Proc. Natl. Acad. Sci. U. S. A. ... Esposito, G., et al. 2000. Cellular and functional defects in a mouse model of heart failure. Am. J. Physiol. 279:H3101-H3112. ...
Glutamate Carboxypeptidase-Like Protein 2 2 3 4 * Beta-Ala-His Dipeptidase 2 3 4 ... G Biosciences Immunotag™ Human CNDP1 (Beta-Ala-His dipeptidase) ELISA and Immunotag™ Beta-Ala-His dipeptidase ELISA Kit ... Lower frequency of the 5/5 homozygous CNDP1 genotype in South Asian Surinamese. (PMID: 19577318) Mooyaart AL … de Heer E ( ... Association between CNDP1 genotype and diabetic nephropathy is sex specific. (PMID: 20332346) Mooyaart AL … De Heer E (Diabetes ...
  • Zinc D-Ala-D-Ala carboxypeptidase (EC 3.4.17.14, Zn2+ G peptidase, D-alanyl-D-alanine hydrolase, D-alanyl-D-alanine-cleaving carboxypeptidase, DD-carboxypeptidase, G enzyme, DD-carboxypeptidase-transpeptidase) is an enzyme. (wikipedia.org)
  • The D-alanyl-d-alanine carboxypeptidase enzyme is essential for virulence in the Schu S4 strain of Francisella tularensis and a dacD mutant is able to provide protection against a pneumonic challenge. (bioportfolio.com)
  • Members of the carboxypeptidase A family are synthesised as inactive molecules with propeptides that must be cleaved to activate the enzyme. (ebi.ac.uk)
  • Hyperproinsulinaemia in obese fat/fat mice associated with a carboxypeptidase E mutation which reduces enzyme activity. (ebi.ac.uk)
  • Cathepsin A is an enzyme that is classified both as a cathepsin and a carboxypeptidase . (wikipedia.org)
  • A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9 (англ. (wikipedia.org)
  • Hydrolysis of Biological Peptides by Human Angiotensin-converting Enzyme -related carboxypeptidase. (sigmaaldrich.com)
  • Human CPN (carboxypeptidase N) is a tetrameric plasma enzyme containing two glycosylated 83 kDa non-catalytic/regulatory subunits that carry and protect two active catalytic subunits. (biochemj.org)
  • Several clinical trials of ADEPT systems based on the bacterial enzyme carboxypeptidase G2 have been done. (aacrjournals.org)
  • The "go or grow" poten-tial of gliomas is linked to the neuropeptide processing enzyme carboxypeptidase E and mediated by metabolic stress. (thefreedictionary.com)
  • With a New York University Cancer Institute colleague, the researchers reported that the mixture of free-floating blood proteins created by the enzyme carboxypeptidase N accurately predicted the presence of early-stage breast cancer tissue in mice and in a small population of human patients. (thefreedictionary.com)
  • Researchers from the Houston Methodist Research Institute and New York University Cancer Institute, conducted experiments on mice models and breast cancer patients, and found that a mixture of free-floating blood proteins created by carboxypeptidase N or CPN (an enzyme that plays a major role in modifying proteins after they are being created), accurately signalled the early stages of the deadly disease. (thefreedictionary.com)
  • PCR detection of the insertion/ deletion polymorphism of the human angiotensin converting enzyme gene (DCP1) (dipeptidyl carboxypeptidase 1). (thefreedictionary.com)
  • For example, angiotensin I (Ang I) is metabolised by the dipeptide carboxypeptidase, angiotensin-converting enzyme (ACE) to form angiotensin II (Ang II) and Ang II is metabolised by the carboxypeptidase, ACE2, producing the vasodilator, angiotensin (1-7) (Ang 1-7) [ 2 - 4 ]. (hindawi.com)
  • 1992). Angiotensin I converting enzyme, ACE (dipeptidyl carboxypeptidase, EC 3.4.15.1), a zinc metal peptidase, plays an important role in this system. (thefreelibrary.com)
  • Cleavage of the pro region activates the enzyme (Wei et al. (origene.com)
  • Prostate-Specific Membrane Antigen (PSMA) is a transmembrane glutamate carboxypeptidase expressed on tumor-associated vasculature that positively regulates angiogenesis in a laminin-dependent manner. (thefreedictionary.com)
  • Glutamate carboxypeptidase II: a polymorphism associated with lower levels of serum folate and hyperhomocysteinemia. (thefreedictionary.com)
  • This antibody is specific for Homo sapiens carboxypeptidase A1 (pancreatic) (CPA1). (novusbio.com)
  • We show here that the Caenorhabditis elegans egl-21 gene encodes a protein that is very similar to carboxypeptidase E (CPE) and is broadly expressed in the nervous system. (jneurosci.org)
  • Gene Ontology (GO) annotations related to this gene include hydrolase activity and carboxypeptidase activity . (genecards.org)
  • The agouti gene was cloned in 1992 and was found to encode a 131 amino acid polypeptide (Bultman et al. (google.com)
  • The gene encoding human AGRP has been cloned and sequenced (Shutter et al. (google.com)
  • Godbole A, Lyga S, Lohse MJ and Calebiro D (2017) Internalized TSH receptors en route to the TGN induce local Gs‐protein signaling and gene transcription. (els.net)
  • A spontaneous point mutation in the coding region of the carboxypeptidase E (CPE) gene in Cpe(fat)/Cpe(fat) mice affects proinsulin processing. (atcc.org)
  • SNP detection of carboxypeptidase E gene and its association with meat quality and carcass traits in Korean cattle. (thefreedictionary.com)
  • Cells deficient in this gene began to die soon after overexpressing a model misfolding protein, a mutant carboxypeptidase Y, even though the UPR was stimulated about fivefold. (alzforum.org)
  • The second position will focus on the functional analysis of the serine carboxypeptidase-like (SCPL) gene family of Arabidopsis. (bio.net)
  • 2000) Cloning of the SNG1 gene of Arabidopsis reveals a role for a serine carboxypeptidase-like protein as an acyltransferase in secondary metabolism. (bio.net)
  • A human carboxypeptidase E gene mutation in an Alzheimer's disease patient causes neurodegeneration, memory deficits and depression. (nih.gov)
  • A novel single nucleotide T980C polymorphism in the human carboxypeptidase E gene results in loss of neuroprotective function. (nih.gov)
  • Whilst three of these, heme oxygenase-1 (HO-1), aquaporin-1 (AQP-1), and B-cell CLL/lymphoma 2 (Bcl-2) have already been associated with EPO-induced renoprotection, this study for the first time suggests carboxypeptidase M (CPM), dipeptidyl peptidase IV (DPPIV), and cytoglobin (Cygb) to play a role in this process. (hindawi.com)
  • Structural features and dynamics of protein unfolding (R. Lange, et al. ). (elsevier.com)
  • Pressure studies on protein folding, misfolding, protein-DNA interactions and amyloidogenesis (D. Ishimaru, et al. ). (elsevier.com)
  • High pressure gel mobility shift analysis and molecular dynamics: investigating specific protein-nucleic acid recognition (T.W. Lynch, et al. ). (elsevier.com)
  • In situ measurements of the solubility of protein crystals under high pressure (Y. Suzuki, et al. ). (elsevier.com)
  • Effects of pressure on growth kinetics of protein crystals (Y. Suzuki, et al. ). (elsevier.com)
  • Penicillin-binding protein 5 expressed by E. coli (P04287) functions as a D-alanyl-D-alanine carboxypeptidase. (embl-heidelberg.de)
  • Penicillin-binding protein 5 (PBP 5) of Escherichia coli functions as ad-alanine carboxypeptidase, cleaving the C-terminal d-alanine residue fromcell wall peptides. (embl-heidelberg.de)
  • Major kininases in rat urine are neutral endopeptidase and carboxypeptidase Y‐like exopeptidase. (nii.ac.jp)
  • Proinsulin is less extensively processed in NIT-2 than in NIT-1 cells, indicating that the Cpe(fat)mutation affects both the endopeptidase and carboxypeptidase reactions. (atcc.org)
  • ChiX is shown to be a zinc-containing metalloenzyme, and in vitro assays demonstrate that ChiX is an l -Ala d -Glu endopeptidase that cleaves the cross-links in bacterial peptidoglycan. (portlandpress.com)
  • Nodule extracts prepared from Glycine max var Woodworth possessed endopeptidase, aminoptidase, and carboxypeptidase actiities. (unl.edu)
  • Aspartic protease, [beta]-galactosidase, peroxidase and serine carboxypeptidase were detected in three Ephedra species. (thefreedictionary.com)
  • Han har sedan 2002 en tjänst som professor i Funktionsgenomik vid Göteborgs universitet. (gu.se)
  • Zinc supplementation of poultry, swine and dairy cattle diets improves the performance as measured by final body weight or feed efficiency ratio (Feng et al . (scielo.br)
  • Analysis of the three-dimensional structure of ACE shows that it bears little similarity to that of carboxypeptidase A, but instead resembles neurolysin 2 and Pyrococcus furiosus carboxypeptidase 3 -zinc metallopeptidases with no detectable sequence similarity to ACE. (nature.com)
  • Structural analyses in combination with comparisons with the recently reported structures of DacB from S. pneumoniae D39 and R6 clearly demonstrate that DacB adopts a zinc-dependent carboxypeptidase fold and belongs to the metallopeptidase M15B subfamily. (nih.gov)
  • Ang II undergoes further processing by the carboxypeptidase ACE2 to form Ang-(1-7). (springer.com)
  • [ 20 ] Ademais, de acordo cos estudos realizados en ratos , a interacción da proteína da espícula do coronavirus co ACE2 induce unha caída nos niveis de ACE2 nas células por medio da internalización e degradación da proteína e así pode contribuír aos danos pulmonares. (wikipedia.org)
  • Tanto os inhibidores de ACE coma os bloqueantes do receptor de anxiotensina que se utilizan para tratar a presion arterial alta mostraron en estudos feitos en roedores que regulan á alza a expresión do ACE2 e así poden afectar a gravidade das infeccións por coronavirus . (wikipedia.org)
  • O ACE2 humano recombinante (rhACE2) suponse que é unha boa terapia nova para a lesión pulmonar aguda , e parece mellorar a hemodinámica pulmonar e a saturación de oxíxeno en bácoros cunha síndrome de disfunción respiratoria aguda inducida por lipopolisacáridos . (wikipedia.org)
  • However, unlike ACE, it functions as a carboxypeptidase, rather than a dipeptidase, and ACE2 activity is not antagonized by conventional ACE inhibitors [ 4 ]. (hindawi.com)
  • A novel subfamily of mouse cytosolic carboxypeptidases. (ebi.ac.uk)
  • The cytosolic carboxypeptidases CCP2 and CCP3 catalyze posttranslational removal of acidic amino acids. (nih.gov)
  • Two critical processing steps are proteolytic cleavage after dibasic residues by proprotein convertases (PCs) and removal of the dibasic residues from the C terminals of the cleaved peptides by carboxypeptidases. (jneurosci.org)
  • Members of subfamily M14B have longer C-termini than those of subfamily M14A [ PMID: 1449602 ], and carboxypeptidase M (a member of the H family) is bound to the membrane by a glycosylphosphatidylinositol anchor, unlike the majority of the M14 family, which are soluble [ PMID: 7674922 ]. (ebi.ac.uk)
  • Members of the A/B subfamily of carboxypeptidases, such as CPA5, contain an approximately 90-amino acid pro region that assists in the folding of the active carboxypeptidase domain. (origene.com)
  • The renin-angiotensin system is a vital regulator of blood pressure and fluid homeostasis (Laragh et al. (thefreelibrary.com)
  • ACE can increase the blood pressure both by catalyzing the conversion of decapeptide angiotensin I to the potent vasoconstricting octapeptide angiotensin II, and by inactivating the vasodilator bradykinin (Bhoola et al. (thefreelibrary.com)
  • The carboxypeptidase A family can be divided into four subfamilies: M14A (carboxypeptidase A or digestive), M14B (carboxypeptidase H or regulatory), M14C (gamma-D-glutamyl-L-diamino acid peptidase I) and M14D (AGTPBP-1/Nna1-like proteins) [ PMID: 7674922 , PMID: 17244818 ]. (ebi.ac.uk)
  • Effect of pressure and pressure-denaturation on fast molecular motions of solvated myoglobin (W. Doster, et al. ). (elsevier.com)
  • 1998). Among the studied inhibitors, only two are specific for MCP, i.e. , the potato carboxypeptidase inhibitor (PCI) and its close homolog found in tomato plants (TCI). (bio-protocol.org)
  • CPR (identical to carboxypeptidase U [CPU], plasma carboxypeptidase B [plasma CPB]) has also been described as an inhibitor of fibrinolysis, and termed TAFI (thrombin activatable fibrinolysis inhibitor). (biomedcentral.com)
  • Herein we describe a simple and accessible microplate method for the study of the specific and dose-response carboxypeptidase A inhibitory activities present in Andean potato tubers. (bio-protocol.org)
  • It was found that several antihypertensive agents such as captopril, lisinopril and enalapril owe their therapeutic efficacy to ACE inhibitory activities (Ondetti et al. (thefreelibrary.com)
  • Chymotrypsin and carboxypeptidase activities were not detected in any midgut fraction examined. (nih.gov)
  • CPA (carboxypeptidase A) is another MC protease, co-localized with chymase in severe atherosclerotic lesions. (portlandpress.com)
  • In higher plants, small proteinaceous protease inhibitors are wound-induced molecules produced as a part of its defense system against insect attack (Graham et al . (bio-protocol.org)
  • Carboxypeptidases (CP), carboxypeptidase N (CPN) and carboxypeptidase R (CPR), have been reported as a protease, which can cleave carboxy-terminal arginine or lysine residues from biologically active peptides, such as C3a and C5a, and regulate their activity. (biomedcentral.com)
  • YaxinBio is specialized in the research and the production of Animal Origin Free recombinant carboxypeptidase B and recombinant trypsin, which are of high importance for the production of human recombinant insulin. (thefreedictionary.com)
  • An ASP carboxy-terminal peptide encompassing amino acids 83-131 has been generated via expression cloning and is purportedly as active as full length ASP (Willard et al. (google.com)
  • Human AGRP contains 11 cysteines, the majority of which are located at the carboxy terminal end of the polypeptide, and form 5 disulfide bridges (Bures et al. (google.com)
  • The L,D-carboxypeptidase DacB plays a key role in the remodelling of Streptococcus pneumoniae peptidoglycan during cell division. (nih.gov)
  • In addition, enzymatic activity assays further confirm that DacB indeed acts as an L,D-carboxypeptidase towards the tetrapeptide L-Ala-D-iGln-L-Lys-D-Ala of the peptidoglycan stem, with Km and kcat values of 2.84 ± 0.37 mM and 91.49 ± 0.05 s(-1), respectively. (nih.gov)
  • Structural and biochemical analyses of the Streptococcus pneumonia L,D-carboxypeptidase DacB. (nih.gov)
  • The complete amino acid sequence of the Zn2+-containing D-alanyl-D-alanine-cleaving carboxypeptidase of Streptomyces albus G". Eur. (wikipedia.org)
  • 1. A carboxypeptidase U (CPU) mutant polypeptide having greater thermal stability than the wild-type polypeptides, which mutant possesses at least two amino acid substitutions relative to the wild-type polypeptide, at least one of which is located at an amino acid residue position relative to SEQ ID NO: 2 selected from: 327, 355 and 357. (freepatentsonline.com)
  • 2. A carboxypeptidase U (CPU) mutant polypeptide according to claim 1, wherein at least two of the amino acid substitutions are selected from: 327, 355 and 357. (freepatentsonline.com)
  • In support of this, they found that removing all the cysteine amino acids from carboxypeptidase stimulated growth in cells overexpressing this mutant. (alzforum.org)
  • Fluctuation of apomyoglobin monitored from H/D exchange and proteolysis under high pressure (N. Tanaka, et al. ). (elsevier.com)
  • The ability of plasma carboxypeptidase B (pCPB) to remove these residues suggests that it may act as a suppressor of these Plg functions. (jci.org)
  • Proprotein convertases (PCs) cleave precursors after dibasic residues, and carboxypeptidases remove basic residues from the C terminals. (jneurosci.org)
  • 37:991-997 [1998]) have prepared various Ala scan mutants, and Perry et al. (google.com)
  • To this end, new methods for the early detection and prognosis of breast cancer, including circulating proteolytic products of carboxypeptidase N, viable circulating tumor cells, and metastasis-related miRNA, are presented in this issue (12-14). (thefreedictionary.com)
  • Carboxypeptidase E is a prediction marker for tumor recurrence in early-stage hepatocellular carcinoma. (nih.gov)
  • This superfamily represents a structural motif found at the C-terminal of penicillin-binding proteins 4 (PBP4) and 5 (PBP5), as well as at the C-terminal of D-Ala-D-Ala carboxypeptidase A, a member of the MEROPS S11 peptidase family (PBP4 and PBP5 also belong to this peptidase family). (ebi.ac.uk)
  • Western Blot: Carboxypeptidase A1/CPA1 Antibody (2A3) [NBP1-47704] - HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY Carboxypeptidase A(Right lane) cDNA for 48 hrs and lysed. (novusbio.com)
  • Carboxypeptidase H-like Immunoreactivity in the Striatum of Cats and Monkeys," Regulatory Peptides, 20:151-159 (1988). (patentgenius.com)
  • Natural peptides with ACE inhibitory activity were discovered first in snake venom (Ondetti et al. (thefreelibrary.com)
  • Carboxypeptidases have functions ranging from digestion of food to selective biosynthesis of neuroendocrine peptides. (origene.com)
  • Sun L, Guo C, Burnett J, Pan J, Yang Z, Ran Y, Sun D. Association between expression of Carboxypeptidase 4 and stem cell markers and their clinical significance in liver cancer development. (jcancer.org)
  • This study aimed to evaluate the expression of carboxypeptidase 4 (CPA4) in hepatitis, liver cirrhosis and liver cancer tissues, and revealed its clinical significance in liver cancer progression. (jcancer.org)
  • Immunohistochemistry-Paraffin: Carboxypeptidase A1/CPA1 Antibody (2A3) [NBP1-47704] - Staining of paraffin-embedded liver using anti-Carboxypeptidase A mouse monoclonal antibody. (novusbio.com)
  • This invention relates to mutant forms of carboxypeptidase U with increased thermal stability relative to wild-type. (freepatentsonline.com)
  • Some have demonstrated efficacy in reducing systolic blood pressure in spontaneously hypertensive rats (SHRs) following their administration (Li et al. (thefreelibrary.com)
  • Enzymes in membrane-like surfactant-based media: perspectives for pressure regulation (N.L. Klyachko, et al. ). (elsevier.com)
  • The potential of carboxypeptidase G.sub.2 -antibody conjugates as anti-tumour agents. (patentgenius.com)
  • coli , most LMM PBP exhibit dd-carboxypeptidase activity, are not essential for growth in routine laboratory media, and contributions to virulent phenotypes remain largely unknown. (bioportfolio.com)