AIDS Vaccines
Vaccines
Viral Vaccines
Vaccines, Synthetic
Vaccines, Inactivated
Vaccines, DNA
Recombinant DNA vectors encoding antigens administered for the prevention or treatment of disease. The host cells take up the DNA, express the antigen, and present it to the immune system in a manner similar to that which would occur during natural infection. This induces humoral and cellular immune responses against the encoded antigens. The vector is called naked DNA because there is no need for complex formulations or delivery agents; the plasmid is injected in saline or other buffers.
Bacterial Vaccines
SAIDS Vaccines
Simian immunodeficiency virus
Macaca mulatta
Vaccination
Vaccines, Subunit
Vaccines, Conjugate
Semisynthetic vaccines consisting of polysaccharide antigens from microorganisms attached to protein carrier molecules. The carrier protein is recognized by macrophages and T-cells thus enhancing immunity. Conjugate vaccines induce antibody formation in people not responsive to polysaccharide alone, induce higher levels of antibody, and show a booster response on repeated injection.
Simian Acquired Immunodeficiency Syndrome
HIV-1
Immunization, Secondary
Acquired Immunodeficiency Syndrome
An acquired defect of cellular immunity associated with infection by the human immunodeficiency virus (HIV), a CD4-positive T-lymphocyte count under 200 cells/microliter or less than 14% of total lymphocytes, and increased susceptibility to opportunistic infections and malignant neoplasms. Clinical manifestations also include emaciation (wasting) and dementia. These elements reflect criteria for AIDS as defined by the CDC in 1993.
Malaria Vaccines
Neutralization Tests
The measurement of infection-blocking titer of ANTISERA by testing a series of dilutions for a given virus-antiserum interaction end-point, which is generally the dilution at which tissue cultures inoculated with the serum-virus mixtures demonstrate cytopathology (CPE) or the dilution at which 50% of test animals injected with serum-virus mixtures show infectivity (ID50) or die (LD50).
HIV Antigens
Gene Products, env
Antibodies, Neutralizing
Papillomavirus Vaccines
Vaccines or candidate vaccines used to prevent PAPILLOMAVIRUS INFECTIONS. Human vaccines are intended to reduce the incidence of UTERINE CERVICAL NEOPLASMS, so they are sometimes considered a type of CANCER VACCINES. They are often composed of CAPSID PROTEINS, especially L1 protein, from various types of ALPHAPAPILLOMAVIRUS.
Meningococcal Vaccines
HIV Envelope Protein gp120
External envelope protein of the human immunodeficiency virus which is encoded by the HIV env gene. It has a molecular weight of 120 kDa and contains numerous glycosylation sites. Gp120 binds to cells expressing CD4 cell-surface antigens, most notably T4-lymphocytes and monocytes/macrophages. Gp120 has been shown to interfere with the normal function of CD4 and is at least partly responsible for the cytopathic effect of HIV.
HIV Infections
Hepatitis B Vaccines
Measles Vaccine
A live attenuated virus vaccine of chick embryo origin, used for routine immunization of children and for immunization of adolescents and adults who have not had measles or been immunized with live measles vaccine and have no serum antibodies against measles. Children are usually immunized with measles-mumps-rubella combination vaccine. (From Dorland, 28th ed)
Pertussis Vaccine
A suspension of killed Bordetella pertussis organisms, used for immunization against pertussis (WHOOPING COUGH). It is generally used in a mixture with diphtheria and tetanus toxoids (DTP). There is an acellular pertussis vaccine prepared from the purified antigenic components of Bordetella pertussis, which causes fewer adverse reactions than whole-cell vaccine and, like the whole-cell vaccine, is generally used in a mixture with diphtheria and tetanus toxoids. (From Dorland, 28th ed)
Immunization
Deliberate stimulation of the host's immune response. ACTIVE IMMUNIZATION involves administration of ANTIGENS or IMMUNOLOGIC ADJUVANTS. PASSIVE IMMUNIZATION involves administration of IMMUNE SERA or LYMPHOCYTES or their extracts (e.g., transfer factor, immune RNA) or transplantation of immunocompetent cell producing tissue (thymus or bone marrow).
Haemophilus Vaccines
Vaccines or candidate vaccines containing antigenic polysaccharides from Haemophilus influenzae and designed to prevent infection. The vaccine can contain the polysaccharides alone or more frequently polysaccharides conjugated to carrier molecules. It is also seen as a combined vaccine with diphtheria-tetanus-pertussis vaccine.
BCG Vaccine
Poliovirus Vaccine, Inactivated
Rabies Vaccines
Injections, Intramuscular
Cholera Vaccines
HIV
Human immunodeficiency virus. A non-taxonomic and historical term referring to any of two species, specifically HIV-1 and/or HIV-2. Prior to 1986, this was called human T-lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV). From 1986-1990, it was an official species called HIV. Since 1991, HIV was no longer considered an official species name; the two species were designated HIV-1 and HIV-2.
env Gene Products, Human Immunodeficiency Virus
Typhoid-Paratyphoid Vaccines
Smallpox Vaccine
A live VACCINIA VIRUS vaccine of calf lymph or chick embryo origin, used for immunization against smallpox. It is now recommended only for laboratory workers exposed to smallpox virus. Certain countries continue to vaccinate those in the military service. Complications that result from smallpox vaccination include vaccinia, secondary bacterial infections, and encephalomyelitis. (Dorland, 28th ed)
Chickenpox Vaccine
Diphtheria-Tetanus-Pertussis Vaccine
HIV Envelope Protein gp160
Gene Products, gag
Proteins coded by the retroviral gag gene. The products are usually synthesized as protein precursors or POLYPROTEINS, which are then cleaved by viral proteases to yield the final products. Many of the final products are associated with the nucleoprotein core of the virion. gag is short for group-specific antigen.
CD8-Positive T-Lymphocytes
Genetic Vectors
DNA molecules capable of autonomous replication within a host cell and into which other DNA sequences can be inserted and thus amplified. Many are derived from PLASMIDS; BACTERIOPHAGES; or VIRUSES. They are used for transporting foreign genes into recipient cells. Genetic vectors possess a functional replicator site and contain GENETIC MARKERS to facilitate their selective recognition.
Mumps Vaccine
Vaccines used to prevent infection by MUMPS VIRUS. Best known is the live attenuated virus vaccine of chick embryo origin, used for routine immunization of children and for immunization of adolescents and adults who have not had mumps or been immunized with live mumps vaccine. Children are usually immunized with measles-mumps-rubella combination vaccine.
Viral Load
Vaccinia virus
Hepatitis A Vaccines
Immunization Schedule
Adjuvants, Immunologic
Substances that augment, stimulate, activate, potentiate, or modulate the immune response at either the cellular or humoral level. The classical agents (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contain bacterial antigens. Some are endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Their mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy of many biological response modifiers is related to their antigen-specific immunoadjuvanticity.
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Dengue Vaccines
CD4-Positive T-Lymphocytes
A critical subpopulation of T-lymphocytes involved in the induction of most immunological functions. The HIV virus has selective tropism for the T4 cell which expresses the CD4 phenotypic marker, a receptor for HIV. In fact, the key element in the profound immunosuppression seen in HIV infection is the depletion of this subset of T-lymphocytes.
Vaccines, Virosome
T-Lymphocytes, Cytotoxic
Immunized T-lymphocytes which can directly destroy appropriate target cells. These cytotoxic lymphocytes may be generated in vitro in mixed lymphocyte cultures (MLC), in vivo during a graft-versus-host (GVH) reaction, or after immunization with an allograft, tumor cell or virally transformed or chemically modified target cell. The lytic phenomenon is sometimes referred to as cell-mediated lympholysis (CML). These CD8-positive cells are distinct from NATURAL KILLER CELLS and NATURAL KILLER T-CELLS. There are two effector phenotypes: TC1 and TC2.
Genes, env
Immunity, Cellular
Viral Hepatitis Vaccines
Poliovirus Vaccine, Oral
A live vaccine containing attenuated poliovirus, types I, II, and III, grown in monkey kidney cell tissue culture, used for routine immunization of children against polio. This vaccine induces long-lasting intestinal and humoral immunity. Killed vaccine induces only humoral immunity. Oral poliovirus vaccine should not be administered to immunocompromised individuals or their household contacts. (Dorland, 28th ed)
Yellow Fever Vaccine
Plague Vaccine
Clinical Trials as Topic
Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries.
Amino Acid Sequence
Fungal Vaccines
Cross Reactions
Rubella Vaccine
A live attenuated virus vaccine of duck embryo or human diploid cell tissue culture origin, used for routine immunization of children and for immunization of nonpregnant adolescent and adult females of childbearing age who are unimmunized and do not have serum antibodies to rubella. Children are usually immunized with measles-mumps-rubella combination vaccine. (Dorland, 28th ed)
Vaccines, Acellular
Epitopes, T-Lymphocyte
Salmonella Vaccines
Drug Design
The molecular designing of drugs for specific purposes (such as DNA-binding, enzyme inhibition, anti-cancer efficacy, etc.) based on knowledge of molecular properties such as activity of functional groups, molecular geometry, and electronic structure, and also on information cataloged on analogous molecules. Drug design is generally computer-assisted molecular modeling and does not include pharmacokinetics, dosage analysis, or drug administration analysis.
T-Lymphocytes
Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.
Vaccines, Virus-Like Particle
Influenza, Human
Gene Products, nef
Products of the retroviral NEF GENE. They play a role as accessory proteins that influence the rate of viral infectivity and the destruction of the host immune system. nef gene products were originally found as factors that trans-suppress viral replication and function as negative regulators of transcription. nef stands for negative factor.
Virus Replication
Vaccines, Attenuated
Disease Models, Animal
Diphtheria-Tetanus-acellular Pertussis Vaccines
International Cooperation
Cytomegalovirus Vaccines
Immunization Programs
Organized services to administer immunization procedures in the prevention of various diseases. The programs are made available over a wide range of sites: schools, hospitals, public health agencies, voluntary health agencies, etc. They are administered to an equally wide range of population groups or on various administrative levels: community, municipal, state, national, international.
Immunoglobulin G
Diphtheria-Tetanus Vaccine
Poliovirus Vaccines
Escherichia coli Vaccines
West Nile Virus Vaccines
Hemagglutination Inhibition Tests
Shigella Vaccines
Antibody Formation
Herpes Zoster Vaccine
Immunity, Humoral
Polysorbates
Brucella Vaccine
Herpesvirus Vaccines
Injections, Intradermal
Influenza A Virus, H1N1 Subtype
Aluminum Hydroxide
Alum Compounds
Herpes Simplex Virus Vaccines
Diphtheria Toxoid
The formaldehyde-inactivated toxin of Corynebacterium diphtheriae. It is generally used in mixtures with TETANUS TOXOID and PERTUSSIS VACCINE; (DTP); or with tetanus toxoid alone (DT for pediatric use and Td, which contains 5- to 10-fold less diphtheria toxoid, for other use). Diphtheria toxoid is used for the prevention of diphtheria; DIPHTHERIA ANTITOXIN is for treatment.
Respiratory Syncytial Virus Vaccines
Cross Protection
Japanese Encephalitis Vaccines
Enzyme-Linked Immunosorbent Assay
An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.
Vaccines, Edible
Whooping Cough
Immunotherapy, Active
Active immunization where vaccine is administered for therapeutic or preventive purposes. This can include administration of immunopotentiating agents such as BCG vaccine and Corynebacterium parvum as well as biological response modifiers such as interferons, interleukins, and colony-stimulating factors in order to directly stimulate the immune system.
Antigens, Protozoan
Vaccine Potency
Measles
Interferon-gamma
The major interferon produced by mitogenically or antigenically stimulated LYMPHOCYTES. It is structurally different from TYPE I INTERFERON and its major activity is immunoregulation. It has been implicated in the expression of CLASS II HISTOCOMPATIBILITY ANTIGENS in cells that do not normally produce them, leading to AUTOIMMUNE DISEASES.
Rickettsial Vaccines
Smallpox
First Aid
Immunity, Mucosal
Nonsusceptibility to the pathogenic effects of foreign microorganisms or antigenic substances as a result of antibody secretions of the mucous membranes. Mucosal epithelia in the gastrointestinal, respiratory, and reproductive tracts produce a form of IgA (IMMUNOGLOBULIN A, SECRETORY) that serves to protect these ports of entry into the body.
Parainfluenza Vaccines
Rotavirus Infections
Influenza A Virus, H5N1 Subtype
A subtype of INFLUENZA A VIRUS comprised of the surface proteins hemagglutinin 5 and neuraminidase 1. The H5N1 subtype, frequently referred to as the bird flu virus, is endemic in wild birds and very contagious among both domestic (POULTRY) and wild birds. It does not usually infect humans, but some cases have been reported.
Influenza A Virus, H3N2 Subtype
Influenza B virus
Species of the genus INFLUENZAVIRUS B that cause HUMAN INFLUENZA and other diseases primarily in humans. Antigenic variation is less extensive than in type A viruses (INFLUENZA A VIRUS) and consequently there is no basis for distinct subtypes or variants. Epidemics are less likely than with INFLUENZA A VIRUS and there have been no pandemics. Previously only found in humans, Influenza B virus has been isolated from seals which may constitute the animal reservoir from which humans are exposed.
Pseudorabies Vaccines
Hemagglutinin Glycoproteins, Influenza Virus
Membrane glycoproteins from influenza viruses which are involved in hemagglutination, virus attachment, and envelope fusion. Fourteen distinct subtypes of HA glycoproteins and nine of NA glycoproteins have been identified from INFLUENZA A VIRUS; no subtypes have been identified for Influenza B or Influenza C viruses.
Papillomavirus Infections
Poliomyelitis
An acute infectious disease of humans, particularly children, caused by any of three serotypes of human poliovirus (POLIOVIRUS). Usually the infection is limited to the gastrointestinal tract and nasopharynx, and is often asymptomatic. The central nervous system, primarily the spinal cord, may be affected, leading to rapidly progressive paralysis, coarse FASCICULATION and hyporeflexia. Motor neurons are primarily affected. Encephalitis may also occur. The virus replicates in the nervous system, and may cause significant neuronal loss, most notably in the spinal cord. A rare related condition, nonpoliovirus poliomyelitis, may result from infections with nonpoliovirus enteroviruses. (From Adams et al., Principles of Neurology, 6th ed, pp764-5)
Rabies
Dose-Response Relationship, Immunologic
Influenza A virus
The type species of the genus INFLUENZAVIRUS A that causes influenza and other diseases in humans and animals. Antigenic variation occurs frequently between strains, allowing classification into subtypes and variants. Transmission is usually by aerosol (human and most non-aquatic hosts) or waterborne (ducks). Infected birds shed the virus in their saliva, nasal secretions, and feces.
Disease Outbreaks
Vaccines, Marker
Haemophilus influenzae type b
Serotyping
Dendritic Cells
Specialized cells of the hematopoietic system that have branch-like extensions. They are found throughout the lymphatic system, and in non-lymphoid tissues such as SKIN and the epithelia of the intestinal, respiratory, and reproductive tracts. They trap and process ANTIGENS, and present them to T-CELLS, thereby stimulating CELL-MEDIATED IMMUNITY. They are different from the non-hematopoietic FOLLICULAR DENDRITIC CELLS, which have a similar morphology and immune system function, but with respect to humoral immunity (ANTIBODY PRODUCTION).
Immunotherapy
Yellow fever virus
Mumps
Neisseria meningitidis, Serogroup B
Immunity, Herd
The non-susceptibility to infection of a large group of individuals in a population. A variety of factors can be responsible for herd immunity and this gives rise to the different definitions used in the literature. Most commonly, herd immunity refers to the case when, if most of the population is immune, infection of a single individual will not cause an epidemic. Also, in such immunized populations, susceptible individuals are not likely to become infected. Herd immunity can also refer to the case when unprotected individuals fail to contract a disease because the infecting organism has been banished from the population.
Viral Envelope Proteins
Layers of protein which surround the capsid in animal viruses with tubular nucleocapsids. The envelope consists of an inner layer of lipids and virus specified proteins also called membrane or matrix proteins. The outer layer consists of one or more types of morphological subunits called peplomers which project from the viral envelope; this layer always consists of glycoproteins.
Pandemics
Virus Shedding
Tetanus
A disease caused by tetanospasmin, a powerful protein toxin produced by CLOSTRIDIUM TETANI. Tetanus usually occurs after an acute injury, such as a puncture wound or laceration. Generalized tetanus, the most common form, is characterized by tetanic muscular contractions and hyperreflexia. Localized tetanus presents itself as a mild condition with manifestations restricted to muscles near the wound. It may progress to the generalized form.
Immunity
Meningitis, Meningococcal
A fulminant infection of the meninges and subarachnoid fluid by the bacterium NEISSERIA MENINGITIDIS, producing diffuse inflammation and peri-meningeal venous thromboses. Clinical manifestations include FEVER, nuchal rigidity, SEIZURES, severe HEADACHE, petechial rash, stupor, focal neurologic deficits, HYDROCEPHALUS, and COMA. The organism is usually transmitted via nasopharyngeal secretions and is a leading cause of meningitis in children and young adults. Organisms from Neisseria meningitidis serogroups A, B, C, Y, and W-135 have been reported to cause meningitis. (From Adams et al., Principles of Neurology, 6th ed, pp689-701; Curr Opin Pediatr 1998 Feb;10(1):13-8)
Proliferative responses to human immunodeficiency virus type 1 (HIV-1) gp120 peptides in HIV-1-infected individuals immunized with HIV-1 rgp120 or rgp160 compared with nonimmunized and uninfected controls. (1/1614)
The proliferative responses to a series of peptides constituting the human immunodeficiency virus type 1 (HIV-1) gp120 sequence were evaluated in 19 HIV-1-infected rgp160 vaccine recipients, 17 HIV-1-infected rgp120 vaccine recipients, 15 HIV-1-infected placebo recipients, and 18 HIV-1-uninfected controls. Many regions of the gp120 molecule were found to contribute proliferative epitopes, although there were clearly regions of relative dominance and silence. Vaccine recipients tended to have broader, more robust, and more frequent peptide recognition than the placebo recipients. Despite the considerable variability in the pattern of peptide recognition among individuals, there was a striking similarity between the rgp160 and rgp120 vaccinee groups as a whole. Low-risk HIV-1-uninfected individuals may react to a few peptides within the gp120 sequence as well, despite a lack of significant response to the whole gp120 protein. (+info)Comparison of immunity generated by nucleic acid-, MF59-, and ISCOM-formulated human immunodeficiency virus type 1 vaccines in Rhesus macaques: evidence for viral clearance. (2/1614)
The kinetics of T-helper immune responses generated in 16 mature outbred rhesus monkeys (Macaca mulatta) within a 10-month period by three different human immunodeficiency virus type 1 (HIV-1) vaccine strategies were compared. Immune responses to monomeric recombinant gp120SF2 (rgp120) when the protein was expressed in vivo by DNA immunization or when it was delivered as a subunit protein vaccine formulated either with the MF59 adjuvant or by incorporation into immune-stimulating complexes (ISCOMs) were compared. Virus-neutralizing antibodies (NA) against HIV-1SF2 reached similar titers in the two rgp120SF2 protein-immunized groups, but the responses showed different kinetics, while NA were delayed and their levels were low in the DNA-immunized animals. Antigen-specific gamma interferon (IFN-gamma) T-helper (type 1-like) responses were detected in the DNA-immunized group, but only after the fourth immunization, and the rgp120/MF59 group generated both IFN-gamma and interleukin-4 (IL-4) (type 2-like) responses that appeared after the third immunization. In contrast, rgp120/ISCOM-immunized animals rapidly developed marked IL-2, IFN-gamma (type 1-like), and IL-4 responses that peaked after the second immunization. To determine which type of immune responses correlated with protection from infection, all animals were challenged intravenously with 50 50% infective doses of a rhesus cell-propagated, in vivo-titrated stock of a chimeric simian immunodeficiency virus-HIVSF13 construct. Protection was observed in the two groups receiving the rgp120 subunit vaccines. Half of the animals in the ISCOM group were completely protected from infection. In other subunit vaccinees there was evidence by multiple assays that virus detected at 2 weeks postchallenge was effectively cleared. Early induction of potent type 1- as well as type 2-like T-helper responses induced the most-effective immunity. (+info)Intracellular adhesion molecule-1 modulates beta-chemokines and directly costimulates T cells in vivo. (3/1614)
The potential roles of adhesion molecules in the expansion of T cell-mediated immune responses in the periphery were examined using DNA immunogen constructs as model antigens. We coimmunized cDNA expression cassettes encoding the adhesion molecules intracellular adhesion molecule-1 (ICAM-1), lymphocyte function associated-3 (LFA-3), and vascular cell adhesion molecule-1 (VCAM-1) along with DNA immunogens, and we analyzed the resulting antigen-specific immune responses. We observed that antigen-specific T-cell responses can be enhanced by the coexpression of DNA immunogen and adhesion molecules ICAM-1 and LFA-3. Coexpression of ICAM-1 or LFA-3 molecules along with DNA immunogens resulted in a significant enhancement of T-helper cell proliferative responses. In addition, coimmunization with pCICAM-1 (and more moderately with pCLFA-3) resulted in a dramatic enhancement of CD8-restricted cytotoxic T-lymphocyte responses. Although VCAM-1 and ICAM-1 are similar in size, VCAM-1 coimmunization did not have any measurable effect on cell-mediated responses. These results suggest that ICAM-1 and LFA-3 provide direct T-cell costimulation. These observations are further supported by the finding that coinjection with ICAM-1 dramatically enhanced the level of interferon-gamma (IFN-gamma) and beta-chemokines macrophage inflammatory protein-1alpha (MIP-1alpha), MIP-1beta, and regulated on activation normal T-cell expression and secreted (RANTES) produced by stimulated T cells. Through comparative studies, we observed that ICAM-1/LFA-1 T-cell costimulatory pathways are independent of CD86/CD28 pathways and that they may synergistically expand T-cell responses in vivo. (+info)Rectal transmission of human immunodeficiency virus type 1 to chimpanzees. (4/1614)
Inoculation of chimpanzees with human immunodeficiency virus type 1 (HIV-1) has been used as a model system to define mechanisms of pathogenesis and to test protective efficacy of candidate HIV-1 vaccines. In most of these studies, the animals were inoculated intravenously. However, because HIV-1 is transmitted primarily across mucosal surfaces, future evaluations of vaccines should employ mucosal routes for administering infectious virus to immunized animals. To develop a model of rectal transmission of HIV-1, chimpanzees were exposed without trauma to 4 different HIV-1 strains at doses ranging from 200 to 10,000 TCIDs. Infection, characterized by seroconversion and repeated isolation of virus from lymphocytes, was established in 1 of 5 animals. This animal was sequentially inoculated with a subtype B and then an E strain and was infected with both strains. The results show that rectal exposure of adult chimpanzees to cell-free HIV-1 was not an efficient mode of transmission in this cohort. (+info)Mucosal vaccination strategies for women. (5/1614)
Women were immunized orally, rectally, or vaginally with a recombinant cholera toxin B-containing vaccine to determine which of these mucosal immunization routes generate the greatest levels of antibody in the female genital tract and rectum. ELISA was used to measure concentrations of cholera toxin B-specific IgA and IgG antibody in serum and secretions before and after three immunizations. Each immunization route similarly increased specific IgG in serum and specific IgA in saliva. Only the vaginal route increased IgA antibodies in genital tract secretions and could be shown to induce a local IgG response. However, vaginal immunization failed to produce antibody in the rectum. In a similar fashion, rectal immunization elicited highest concentrations of locally derived IgA and IgG antibody in the rectum but was ineffective for generating antibody in the genital tract. The data suggest that local immunization may induce the greatest immune responses in the female genital tract and rectum of humans. (+info)Detection of intracellular antigen-specific cytokines in human T cell populations. (6/1614)
Determination of antigen-specific cytokine responses of T lymphocytes after vaccination is made difficult by the low frequency of responder cells. In order to detect these responses, the profile of intracellular cytokines was analyzed using flow cytometry after antigenic expansion. Peripheral blood mononuclear cells were stimulated with antigens for 5 days, further expanded with interleukin (IL)-2, and then restimulated on day 10. Cytokine production was detected by intracellular staining with monoclonal antibodies after saponin-based permeabilization. Influenza expansion resulted in specific interferon-gamma (IFN-gamma) production of 6%-20%, with less IL-4 production (0%-2%). Tetanus toxoid resulted in even greater production. IL-4 and IFN-gamma were produced mainly by memory cells of the CD45RO+ phenotype. IFN-gamma production was contributed by both CD4 and CD8 populations. These methods were then applied to a clinical trial of a candidate human immunodeficiency virus type 1 vaccine. Antigen-specific increases in IFN-gamma were measured, which corresponded to antibody production, lymphoproliferation, and skin testing. (+info)Protection of Macaques against pathogenic simian/human immunodeficiency virus 89.6PD by passive transfer of neutralizing antibodies. (7/1614)
The role of antibody in protection against human immunodeficiency virus (HIV-1) has been difficult to study in animal models because most primary HIV-1 strains do not infect nonhuman primates. Using a chimeric simian/human immunodeficiency virus (SHIV) based on the envelope of a primary isolate (HIV-89.6), we performed passive-transfer experiments in rhesus macaques to study the role of anti-envelope antibodies in protection. Based on prior in vitro data showing neutralization synergy by antibody combinations, we evaluated HIV immune globulin (HIVIG), and human monoclonal antibodies (MAbs) 2F5 and 2G12 given alone, compared with the double combination 2F5/2G12 and the triple combination HIVIG/2F5/2G12. Antibodies were administered 24 h prior to intravenous challenge with the pathogenic SHIV-89.6PD. Six control monkeys displayed high plasma viremia, rapid CD4(+)-cell decline, and clinical AIDS within 14 weeks. Of six animals given HIVIG/2F5/2G12, three were completely protected; the remaining three animals became SHIV infected but displayed reduced plasma viremia and near normal CD4(+)-cell counts. One of three monkeys given 2F5/2G12 exhibited only transient evidence of infection; the other two had marked reductions in viral load. All monkeys that received HIVIG, 2F5, or 2G12 alone became infected and developed high-level plasma viremia. However, compared to controls, monkeys that received HIVIG or MAb 2G12 displayed a less profound drop in CD4(+) T cells and a more benign clinical course. These data indicate a general correlation between in vitro neutralization and protection and suggest that a vaccine that elicits neutralizing antibody should have a protective effect against HIV-1 infection or disease. (+info)Mucosal vaccination overcomes the barrier to recombinant vaccinia immunization caused by preexisting poxvirus immunity. (8/1614)
Overcoming preexisting immunity to vaccinia virus in the adult population is a key requirement for development of otherwise potent recombinant vaccinia vaccines. Based on our observation that s.c. immunization with vaccinia induces cellular and antibody immunity to vaccinia only in systemic lymphoid tissue and not in mucosal sites, we hypothesized that the mucosal immune system remains naive to vaccinia and therefore amenable to immunization with recombinant vaccinia vectors despite earlier vaccinia exposure. We show that mucosal immunization of vaccinia-immune BALB/c mice with recombinant vaccinia expressing HIV gp160 induced specific serum antibody and strong HIV-specific cytotoxic T lymphocyte responses. These responses occurred not only in mucosal but also in systemic lymphoid tissue, whereas systemic immunization was ineffective under these circumstances. In this context, intrarectal immunization was more effective than intranasal immunization. Boosting with a second dose of recombinant vaccinia was also more effective via the mucosal route. The systemic HIV-specific cytotoxic T lymphocyte response was enhanced by coadministration of IL-12 at the mucosal site. These results also demonstrate the independent compartmentalization of the mucosal versus systemic immune systems and the asymmetric trafficking of lymphocytes between them. This approach to circumvent previous vaccinia immunity may be useful for induction of protective immunity against infectious diseases and cancer in the sizable populations with preexisting immunity to vaccinia from smallpox vaccination. (+info)
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JCI -
DNA priming and gp120 boosting induces HIV-specific antibodies in a randomized clinical trial
Merck HIV Vaccine Trial Kills Participants: Could This Have Been Avoided?
JCI -
Volume 129, Issue 11
JCI -
Volume 129, Issue 11
JCI -
Welcome
Study: Many Americans think HIV vaccine already exists (8677) | Advocate.com
Toward an AIDS Vaccine: Lessons From Natural Simian Immunodeficiency Virus Infections of African Nonhuman Primate Hosts - PubMed
OHSU AIDS vaccine candidate appears to completely clear virus from the body
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Clinical Alert: Immunizations Are Discontinued in Two HIV Vaccine Trials
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Nabi Biopharmaceuticals Announces Successful Final Results of NicVAX(R) Immunogenicity Study; Increased Antibody Response...
Effect of therapeutic HIV recombinant poxvirus vaccines on the size of by Deborah Persaud, Katherine Luzuriaga et al.
Antibody-Dependent Cellular Cytotoxicity-Mediating Antibodies from an HIV-1 Vaccine Efficacy Trial Target Multiple Epitopes and...
HIV vaccines may induce HIV antibodies in trial participants, can cause false-positive test result
Harvard Medical School Vaccine Clinical Trials Unit - Raphael Dolin
British Library EThOS: Formulation strategies for the mucosal delivery of HIV vaccines
JCI -
Antibody Fc effector functions and IgG3 associate with decreased HIV-1 risk
JCI -
Antibody Fc effector functions and IgG3 associate with decreased HIV-1 risk
Frontiers | Enforced OX40 Stimulation Empowers Booster Vaccines to Induce Effective CD4+ and CD8+ T Cell Responses against...
NIH-Led Scientists Find Antibodies that Prevent Most HIV Strains from Infecting Human Cells - Healthcanal.com : Healthcanal.com
Independent Evaluation Group - Wikipedia
Consequences of Adenovirus Vector Vaccination on T Cell Activation and by Irene Bukh
Advertising=S Longitudinal Effects on Brand Attitudes: the Moderating Roles of Evaluation Goals and Attitude Confidence by...
Modeling the economic benefits of an AIDS vaccine<...
Comparative Immunogenicity in Rhesus Monkeys of DNA Plasmid, Recombinant Vaccinia Virus, and Replication-Defective Adenovirus...
Corrigendum to The Starting Treatment for Ethanol in Primary care Trials (STEP Trials): Protocol for three parallel multi-site...
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Vaccine regimen fails to prevent HIV-1 infection in South Africa.
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Synthesis and Vaccine Evaluation of the Tumor Associated Carbohydrate Antigen RM2 from Prostate Cancer - Hong-Yang Chuang -...
GeoVax Vaccine Only 5th AIDS Vaccine Moving to Phase 2 Hu... ( ATLANTA Feb. 25 /- GeoVax Labs In...)
HCV Research and News: Promising AIDS Vaccine Being Developed
AIDS Vaccine 200
... through its Action Cycling 200 and AIDS Vaccine 200 rides has donated a total of $2,781,090 for AIDS vaccine research and AIDS- ... The majority of these funds ($557,000) has gone towards AIDS vaccine research at Emory Vaccine Center. The ride also ... who has helped raise big bucks for AIDS research - and his company Pallotta announces end to AIDS Vaccine Rides: Even with ... 2.4 million to the Emory Vaccine Center, one of the world's leading vaccine research centers working to find an HIV vaccine. ...
AIDS Vaccine Advocacy Coalition
"AIDS Vaccine Advocacy Coalition". AVAC. Retrieved 2008-12-08. "AIDS Vaccine Advocacy Coalition(AVAC)". Archived from the ... the International AIDS Vaccine Initiative, Until There's a Cure Foundation, Broadway Cares/Equity Fights AIDS, the Gill ... AVAC works to provide independent analysis, policy advocacy, public education and mobilisation to enhance AIDS vaccine research ... HIV vaccine research, Organizations established in 1995, HIV/AIDS organizations in the United States, Vaccination-related ...
World AIDS Vaccine Day
... , also known as HIV Vaccine Awareness Day, is observed annually on May 18. HIV vaccine advocates mark the ... preventive HIV vaccine can limit and eventually eliminate the threat of AIDS." The first World AIDS Vaccine Day was observed on ... South African AIDS Vaccine Initiative (SAAVI) World AIDS Day Bill Clinton's commencement speech at Morgan State University AIDS ... International AIDS Vaccine Initiative The South Africa AIDS Vaccine Initiative (SAAVI) (Articles lacking in-text citations from ...
International AIDS Vaccine Initiative
... to evaluate the challenges facing HIV/AIDS vaccine development and identify ways to jump-start research. The International AIDS ... The International AIDS Vaccine Initiative (IAVI) is a global not-for-profit, public-private partnership working to accelerate ... It also partners with civil society organizations and other entities to advocate jointly for the development of AIDS vaccines, ... To address major obstacles in AIDS vaccine development, IAVI partners with HIV researchers from around the world. Its ...
Collaboration for AIDS Vaccine Discovery
The Collaboration for AIDS Vaccine Discovery (CAVD) is an international network of scientists, research organizations, and ... The CAVD was founded in 2006 when the Bill & Melinda Gates Foundation donated $287 million USD to promote HIV vaccine research ... The CAVD itself supports the Global HIV Vaccine Enterprise. The network comprises many individual institutions. "Gates ... Official website (Orphaned articles from August 2019, All orphaned articles, AC with 0 elements, HIV/AIDS research ...
South African AIDS Vaccine Initiative
"Development of an AIDS vaccine: perspective from the South African AIDS Vaccine Initiative". BMJ: British Medical Journal. 329 ... HIV/AIDS research organisations, HIV vaccine research, HIV/AIDS in South Africa, Medical research institutes in South Africa, ... The South African AIDS Vaccine Initiative (SAAVI) was a South African organisation with the mission of coordinating the ... Faul, Michelle (20 June 2009). "South Africa launches AIDS vaccine trial but slashes research funding". washingtonexaminer.com ...
Oral polio vaccine AIDS hypothesis
Vaccine. 22 (15-16): 1831-1835. doi:10.1016/j.vaccine.2004.01.028. PMID 15121291. Koprowski (1992). "AIDS and the Polio Vaccine ... The oral polio vaccine (OPV) AIDS hypothesis is a now-discredited hypothesis that the AIDS pandemic originated from live polio ... The second vaccine, an oral polio vaccine (OPV), is a live-attenuated vaccine, produced by the passage of the virus through non ... I never made, nor do I know of anyone in the lab who made polio vaccine in chimpanzee cells. The OPV AIDS hypothesis has been ...
Vaccine Research Center
"Nabel to Head AIDS Vaccine Institute". www.science.org. Retrieved 2022-02-11. "NIAID selects new director of the Vaccine ... The discovery, a potentially landmark one in the drive to find a vaccine for AIDS should it be validated and further improved. ... Anthony Fauci regarding research addressing HIV/AIDS. Recognizing the potential impact a vaccine could make in decreasing the ... Notable visits to Vaccine Research Center President George W. Bush visits the Vaccine Research Center President Barack Obama ...
HIV vaccine development
Global Alliance for Vaccines and Immunization (GAVI) International AIDS Vaccine Initiative (IAVI) AIDS Vaccine Advocacy ... An HIV vaccine is a potential vaccine that could be either a preventive vaccine or a therapeutic vaccine, which means it would ... Viruses portal Cabotegravir COVID-19 vaccine HIV Vaccine Trials Network World AIDS Vaccine Day Broadly neutralizing HIV-1 ... Vaccine Research Center (VRC)- Information concerning Preventive HIV vaccine research studies NIAID HIV vaccine site (DAIDS) ...
Vaccine and Infectious Disease Organization
"New Money Aids Saskatchewan's Search for COVID-19 Vaccine , News and Media". Government of Saskatchewan. Retrieved March 26, ... The Vaccine and Infectious Disease Organization - International Vaccine Centre (VIDO-InterVac) is a research organization of ... "Combatting Infectious Disease Through Vaccine Research: VIDO/InterVac at the U of S" (PDF). University of Saskatchewan. 2009. ... "University of Saskatchewan University of Saskatchewan, International Vaccine Centre (InterVac)". MCW Hemsiphere Ltd. Retrieved ...
Duke University Human Vaccine Institute
In 2005, DHVI became the home to the NIAID funded Center for HIV/AIDS Vaccine Immunology, a $350M grant to speed the ... DHVI investigators have been at the forefront in the battle against AIDS and specifically in the quest for an HIV vaccine. In ... development of an AIDS vaccine. Led by Barton Haynes, MD this effort has had a major effect on the progress of the entire field ... The vaccine strategy of the Duke CHAVI-ID is based on identifying and targeting novel HIV-1 vulnerabilities to B, T, and NK ...
Global HIV Vaccine Enterprise
Coordinating Committee of the Global HIV/AIDS Vaccine Enterprise (2005) The Global HIV/AIDS Vaccine Enterprise: Scientific ... 18 January 2005 Global HIV/AIDS Vaccine Enterprise (2005). "The Global HIV/AIDS Vaccine Enterprise: Scientific Strategic Plan ... International AIDS Vaccine Initiative, French National Agency for Research on AIDS and Viral Hepatitis. In June 2003, a group ... The article asserted that current attempts to develop such a vaccine were insufficient and that a renewed HIV vaccine research ...
T-cell vaccine
T-cell vaccines underwent clinical trials for HIV/AIDS. As of July 2012[update] none have been approved. As December 2020, The ... A T-cell vaccine is a vaccine designed to induce protective T-cells. T-cell vaccines are designed to induce cellular immunity. ... Vaccines, All stub articles, COVID-19 vaccine stubs, Vaccine stubs). ... "T-cell Vaccines Could Treat Elusive Diseases". Commissioner, Office of the (2020-12-14). "FDA Takes Key Action in Fight Against ...
Vaccine-naive
Paediatric European Network for Treatment of AIDS (PENTA) Vaccines Group; Penta Steering, C.; Children's HIV Association (CHIVA ... Vaccine-naive is a lack of immunity, or immunologic memory, to a disease because the person has not been vaccinated. There are ... Vaccine-naive persons threaten what epidemiologists call herd immunity. This is because vaccinations provide not just ... Wallace, H. Shortages require practices to take extra measures to keep patients up-to-date on vaccines: Calling the shots. AAP ...
Phillip Ragon
Trafton, Anne (4 February 2009). "Alum's $100 million gift targets AIDS vaccines". Archived from the original on 2009-02-05. ... In 2009, Ragon pledged to donate US $100 million over 10 years period for AIDS research through the Phillip T. and Susan M. ... "Businessman donates $100 million to AIDS research". Reuters. 4 February 2009. Retrieved 2020-11-23. "Mass General Receives $200 ... 200 million to Massachusetts General Hospital for a vaccine-research center. In 2022, Ragon received the Golden Plate Award of ...
Barney S. Graham
... where he led the first human trial on the AIDS vaccine. The results of the trial found that the two experimental AIDS vaccines ... "New experiment with AIDS vaccines called encouraging". The Sacramento Bee. June 22, 1991. Retrieved January 10, 2021 - via ... "First human tests of AIDS vaccine slated". Auburn Journal. August 12, 1987. Retrieved January 10, 2021 - via newspapers.com. " ... In 2000, the National Institutes of Health (NIH) recruited him to create a vaccine evaluation clinic (Vaccine Research Center ...
Raghavan Varadarajan
Merck have tested the a few vaccines and some of the other proposals are being tested by International AIDS Vaccine Initiative ... organized by the Department of Biotechnology and International AIDS Vaccine Initiative for the development of HIV vaccines. He ... International AIDS Vaccine Initiative. 2 May 2007. Retrieved 19 October 2016. "Seminar by Prof. Raghavan Varadarajan". ... his team developed a number of immunogens which have been demonstrated to have positive effect as HIV-1 vaccines and he holds ...
Long-term nonprogressor
"Understanding Long-term Nonprogressors". International AIDS Vaccine Initiative. Archived from the original on October 9, 2006. ... AIDS. 20 (5): 685-9. doi:10.1097/01.aids.0000216368.23325.bc. PMID 16514298. S2CID 27932324. Thorven, M; Grahn, A; Hedlund, KO ... "Mitochondrial DNA haplogroups influence AIDS progression". AIDS. 22 (18): 2429-39. doi:10.1097/QAD.0b013e32831940bb. ISSN 0269- ... Without the symptoms of AIDS, many LTNP patients may not know they are infected. Genetic traits that confer greater resistance ...
Immunome
International AIDS Vaccine Initiative. 18 (3): 14-7. PMID 25401194. Plaza, David F; Gomez, Manuel; Patarroyo, Manuel (31 ... De Groot, Anne (1 December 2009). "Exploring the immunome: A brave new world for human vaccine development". Human Vaccines. 5 ... Human Vaccines & Immunotherapeutics. 14 (9): 2214-2216. doi:10.1080/21645515.2018.1476813. PMID 6183335. "The Human Vaccines ... The development of vaccines is also an application of immunome study as shown by Carlos F. Suárez and his colleagues. They were ...
The Exposé
"Facebook yanks Bolsonaro video claiming vaccines cause AIDS". NBC News. Reuters. 26 October 2021. Retrieved 22 October 2022. " ... have full blown Covid-19 vaccine induced acquired immunodeficiency syndrome (AIDS) by the end of [the month]." In March 2022, ... "Facebook yanks Bolsonaro video claiming vaccines cause AIDS". Associated Press. Retrieved 22 October 2022. "Facebook, YouTube ... "The COVID-19 vaccines protect people from severe COVID-19 and don't weaken the immune system". Health Feedback. 28 January 2022 ...
Hildegund C. J. Ertl
"Building a better vaccine Hildegund Ertl and her Philadelphia researchers pursue a new way to conquer the AIDS virus, threats ... human papilloma virus vaccines, rabies vaccine models, universal influenza vaccine, vaccines to Epstein-Barr virus, and using ... Her research is focused on developing vaccines for AIDS and various forms of cancer. Her lab is currently working on projects ... In interviews, Ertl has been cautious and critical when it comes to the development of vaccines for AIDS. Her research has ...
Immortality
Vaccines are being researched for AIDS and tuberculosis. Genes associated with type 1 diabetes and certain types of cancer have ...
Hilary Koprowski
... "oral polio vaccine AIDS hypothesis", which posited that the AIDS pandemic originated from live polio vaccines such as ... Albert Sabin Discredited HIV/AIDS origins theories Jonas Salk List of Polish people Poles Polio vaccine Wistar Institute ... 119-130 online Archived 2008-08-02 at the Wayback Machine Hilary Koprowski (1992). "AIDS and the polio vaccine". Science. 257 ( ... "Origin of AIDS: contaminated polio vaccine theory refuted" (PDF file, direct download 203 KB). Nature. 428 (6985): 820. Bibcode ...
Linda-Gail Bekker
In 2018 she was elected to the board of the International AIDS Vaccine Initiative. She is concerned about Donald Trump ... "Board of Directors". IAVI - International AIDS Vaccine Initiative. Archived from the original on 14 April 2017. Retrieved 14 ... In 2016 she was elected President of the International AIDS Society. She gave the opening address at the International AIDS ... She saw young people dying from HIV/AIDS and was frustrated that she couldn't help them. Her PhD was funded by the John E. ...
Sherri Tenpenny
Gage, Brandon (3 April 2022). "Anti-vax activist claims COVID-19 vaccines cause AIDS". Salon. Archived from the original on 3 ... Srikanth, Anagha (24 March 2021). "12 prominent people opposed to vaccines are responsible for two-thirds of anti-vaccine ... every fully vaccinated person over the age of 30 may have the equivalent of full-blown vaccine-induced immune suppressed AIDS ... During the course, Tenpenny explains her views on the immune system and vaccines, and Hunt instructs participants on how best ...
Ian Gust
... particularly in the prevention of hepatitis and AIDS. Gust, Ian D.; Kahn, Patricia; Koff, Wayne C. (2007). AIDS Vaccine ... Gust's area of work is in the development of drugs and vaccines against viral diseases and he is best known for the development ... "Professor Ian Gust". Vaccine and Immunotherapy Technologies. Sir Mark Oliphant Conferences. 2008. Archived from the original on ... The most cited are: Gust, I.D. "Epidemiological patterns of hepatitis A in different parts of the world" (1992) Vaccine, 10 ( ...
Howard Bachrach
Kendall, Don (June 20, 1981). "Vaccine to aid human, animal diseases". Nashua Telegraph. Associated Press. Retrieved June 2, ... This vaccine was the first one developed using genetic engineering. Bachrach retired in 1981. In 1982, he was elected to ... In turn, the bacterium produced a large amount of VP3, and the Bachrach team felt that this could lead to a vaccine against the ... The development of the foot-and-mouth disease vaccine, which was only effective against a single strain of the illness, taught ...
Ocean Biomedical
"Immune children aid malaria vaccine hunt". BBC News. May 22, 2014. Raj, Dipak K.; Nixon, Christian P.; Nixon, Christina E.; ... "Groundbreaking malaria vaccine discovery". April 22, 2020. "Punjab NRI's company to try its new malaria vaccine on Covid-19 ... "New Malaria Vaccine Shows Promise in Mice". www.science.org. "partnerships". ocean biomedical. "Brown Alpert Medical School ... Ocean Biomedical has worked on developing vaccines for tropical diseases such as malaria, as well as for emerging diseases like ...
Eckard Wimmer
"Live attenuated influenza virus vaccines by computer-aided rational design". Nat. Biotechnol. 28 (7): 723-727. doi:10.1038/nbt. ... This strategy allows for the generation of new vaccines in a very short time. Recently, Wimmer's lab has elucidated the key ... synthetic biology has led to a new kind of RNA virus genetics and has been used to develop rapid methods for computer-aided ...
Mary Lou Clements-Mann
An Expert on AIDS Vaccines". The New York Times. Retrieved July 18, 2014. "Founder - Mary Lou Clements-Mann". Center for ... She was a member of the US Centers for Disease Control Advisory Committee on the Children's Vaccine Initiative and the World ... Mary Lou Clements-Mann (September 17, 1946 - September 2, 1998) was the longtime head of the Division of Vaccine Sciences at ... During this time, she joined the university's Center for Vaccine Development. She later became the chief of the clinical ...
Cervical cancer
The vaccines are between 92% and 100% effective against HPV 16 and 18 up to at least 8 years. HPV vaccines are typically given ... Also, not only does it aid in the development of HPV, but also if the woman is already HPV-positive, she is at an even greater ... 2006: First HPV vaccine was approved by the FDA. 2015: HPV Vaccine shown to protect against infection at multiple body sites. ... August 2018). "Evidence for single-dose protection by the bivalent HPV vaccine-Review of the Costa Rica HPV vaccine trial and ...
Hurricane Inez
"U.S. Planes Aid Victims of Hurricane". Gettysburg Times. Associated Press. 1966-10-15. Retrieved 2013-02-22. "15 Die as Mercy ... The United States also sent vaccines and 4,360 pounds of food. In Cuba, sailors on the USS America (CV-66) spent about 1,700 ... Damage totaled $20.35 million in Haiti, prompting the United States government to send aid for the first time in nearly ten ... Drew Pearson (1966-11-20). "Haiti Back on U.S. Aid Rolls". The Press-Courier. Retrieved 2013-02-22. "Inez Sweeps Florida Keys ...
Benjamin Franklin
And if a sparrow cannot fall to the ground without his notice, is it probable that an empire can rise without his aid? We have ... "A Founding Father's Vaccine Regret". Retrieved September 27, 2021 - via Boston Globe. Korn, Michael (September 28, 2015). " ... His efforts proved vital for the American Revolution in securing French aid. He was promoted to deputy postmaster-general for ... "He waged a public relations campaign, secured secret aid, played a role in privateering expeditions, and churned out effective ...
Helen Rees
... and the Center for HIV/AIDS Vaccine Immunology Immunogen Discovery (CHAVI-ID) Scientific Advisory Board. In 2001 Rees was made ... She chaired the WHO Committee on the STV Vaccine Roadmap and continues to advise WHO on STI vaccine development and on STI ... and HIV vaccines, and vaccine use in humanitarian emergencies. She is a member of the SAGE Working Group on Measles and Rubella ... Rees is the current Chair of the WHO SAGE Working Group on Ebola Vaccines, the TFI Working group on Ebola and she chaired the ...
GeoVax
"Expansion of HIV/AIDS Vaccine Program Announced by GeoVax Labs, Inc." Media Release. April 11, 2011. "Encouraged By Early ... The vaccine works with a combined DNA vaccine and MVA (modified vaccinia Ankara) vaccine both of which lead to the insertion of ... "GeoVax Labs Granted Allowance by FDA To Start Phase 1 Clinical Trial for HIV/AIDS Therapeutic Vaccine: Company Will Begin Non- ... "ARCA Seeks Volunteers for Historic HIV Vaccine Trial." GA Voice. June 11, 2010. GeoVax Labs, Inc. "New Progress for HIV/AIDS ...
T-cell vaccination
Crohn's disease and AIDS. Cohen IR (2001). "T-cell vaccination for autoimmune disease: a panorama". Vaccine. 20 (5-6): 706-10. ... Expert Rev Vaccines. 1 (3): 285-92. doi:10.1586/14760584.1.3.285. PMID 12901569. v t e (Immunology, All stub articles, Vaccine ...
Wingcopter
As part of a humanitarian aid project in Malawi in 2019/20, medicines were delivered by Wingcopter to remote areas that were ... Wingcopter has also been active with UNICEF and DHL in delivering vaccines and other medications in Vanuatu and some African ... Copley, Caroline (2021-01-25). "Drone company Wingcopter gets more firepower in vaccine delivery race". Reuters. Retrieved 2021 ... "Vanuatu awards international drone companies with commercial contracts for vaccine delivery". www.unicef.org. Retrieved 2020-09 ...
2022 monkeypox outbreak
Another monkeypox vaccine, the modern LC16m8 vaccine was developed in Japan as a national asset, and the manufacturer said it ... had HIV/AIDS, of which 96% were on antiretroviral therapy, while 57% of the persons who were not known to have HIV infection ... a number of countries have stated they are buying vaccines and/or releasing vaccines from national stockpiles for use in the ... FDA Authorizes Emergency Use of JYNNEOS Vaccine to Increase Vaccine Supply". FDA. 9 August 2022. Retrieved 14 August 2022. " ...
Diseases of poverty
... therefore accelerating the progression of AIDS. AIDS is a disease of the human immune system caused by the human ... Malaria vaccines are an area of intensive research. Intestinal parasites are extremely prevalent in tropical areas. These ... Elieen Stillwaggon, Aids and the Ecology of Poverty. Oxford University Press. New York "Non communicable diseases". www.who.int ... Critics of AIDS policies promoting safe sexual behaviors believe that these policies miss the biological mechanisms and social ...
Andrew Wakefield
... which is taken to include live attenuated measles vaccine virus, measles virus, mumps vaccine virus and rubella vaccine virus, ... Deer, Brian (31 December 2006). "MMR doctor given legal aid thousands". The Times. London, UK. Retrieved 10 August 2007 - via ... His continued claims that the vaccine is harmful have contributed to a climate of distrust of all vaccines and the reemergence ... would succeed in marketing products and developing a replacement vaccine if "public confidence in the MMR vaccine was damaged ...
E-government
Now, it is being used for travel; entering commercial buildings, hospitals, and schools within the Kingdom; setting vaccine ... Lyman, Jay (1 February 2006). "AT&T Sued for Role in Aiding US Government Surveillance". TechNewsWorld. Retrieved 28 February ...
Timeline of the COVID-19 pandemic in the United Kingdom (July-December 2021)
French vaccine manufacturer Valneva is seeking an apology from the UK government after doubt was cast over whether its vaccine ... "Government wins vote to lock in cuts to overseas aid". BBC News. 13 July 2021. Retrieved 28 August 2021. "Most Covid rules set ... Vaccines Minister Nadhim Zahawi subsequently confirms all children in this age group will be offered a single vaccine. Figures ... The vaccine had previously been omitted from a published list of approved vaccines, something that attracted criticism from MPs ...
List of people from Newton, Massachusetts
... setting the stage for the development of a vaccine Judy Smith, nurse who disappeared from Philadelphia in 1997; found murdered ... head of the World Health Organization's global AIDS project Charles Johnson Maynard, naturalist and ornithologist; lived in the ...
Arma 3
... the International Development and Aid Project (IDAP), a non-governmental organization specializing in humanitarian aid; the ... With no data, vaccine tests are ineffective and a cure is never made, allowing Atrox to spread and worsen. Santiago, paid ... If Santiago kills Miller and gives the counteragent to Drábek, the Global Health Initiative develops a vaccine and a cure. But ... However, by the time the vaccine is made and distributed, countless Tanoans have already died. Though Tanoa is finally at peace ...
Yves Lévy
In 2006, Lévy became scientific director of the vaccine programme of the French National Agency for Research on AIDS and Viral ... Lévy became a professor of clinical immunology, specializing on immunotherapies and vaccines for HIV infection, ... Industry Collaboration Group International AIDS Society (IAS). Council World Health Summit. Board of Directors French ... he created the Vaccine Research Institute laboratory of excellence under the Investissement d'Avenir (Investment for the Future ...
Nicki Minaj
Shortly after, Minaj recommended other people get the vaccine and set up a Twitter poll on COVID-19 vaccine brands. She tweeted ... Rodriguez, Cindy Y. "Nicki Minaj And Ricky Martin Promote MAC Viva Glam, Bring HIV/AIDS Awareness To Latin America". The ... The White House offered her a phone call with a doctor to answer questions about the safety of the vaccine. In an Instagram ... In September 2021, Minaj announced she would not be attending the 2021 Met Gala due to the COVID-19 vaccine requirement. She ...
Race Against Time: Searching for Hope in AIDS-Ravaged Africa
... investing in vaccine and microbicide research; eliminating school fees for primary education; using microcredit money pots for ... HIV/AIDS in literature, HIV/AIDS in Africa, Massey Lectures books, Books about Africa, House of Anansi Press books, English- ... Lewis wrote the book, not as an employee of the UN, but as a citizen concerned with the world's response to the AIDS challenge ... Several reviewers noted that the book could be used as an effective tool to educate about the HIV/AIDS crisis and the plight of ...
History of San Marino
In April 2021, the nation received headlines for using the Russian Sputnik V COVID-19 vaccine rather than vaccines approved by ... He was aiding certain rebels, and acting possibly contrary to the orders of Pope Clement XII. However, civil disobedience ... stokes envy with speedy Russian-supplied vaccine campaign", Washington Post, 2 April 2021 "Shut Out on Vaccines, Tiny San ... the EU following a slow rollout for the latter vaccines. At the 2020 Summer Olympics, San Marino became the smallest country to ...
Timeline of the Bill Clinton presidency (1993)
October 1 - In a statement, President Clinton states his directing of the federal government to provide aid to India in ... vaccine manufacturers; and Federal, State, and local governments to protect our Nation's children from the deadly onslaught of ... Remarks on the Observance of World AIDS Day (December 1, 1993) Exchange With Reporters Prior to Discussions With Prime Minister ... Commission in the Indian Treaty Room of the Old Executive Office Building and delivers an address in observance to Worlds AIDS ...
Correlates of immunity
doi:10.1186/s12929-022-00853-8. International AIDS Vaccine Initiative HIV Vaccine Trials Network (Articles with short ... "COVID-19 vaccine update: vaccine effectiveness, SARS-CoV-2 variants, boosters, adverse effects, and immune correlates of ... The fact that the correlates of immunity/protection remain unclear is a significant barrier to HIV vaccine research. There is ... However, without knowing the correlates of immunity, scientists cannot know exactly what sort of immune response a vaccine ...
Brucella suis
DnaK is part of the heat shock protein 70 family, and aids in the correct synthesis and activation of certain virulence factors ... The Brucella abortus (rough LPS Brucella) vaccine, developed for bovine brucellosis and licensed by the USDA Animal Plant ... but there is currently no approved vaccine for swine brucellosis. In the United States, B. suis was the first biological agent ...
List of timelines
Timeline of AIDS (1930s-present) Timeline of antibiotics (1935 CE-present) Timeline of medicine and medical technology (27th ... century BCE-present) Timeline of sexual orientation and medicine (1886-present) Timeline of vaccines (1796-present) 2009 flu ...
Texas Biomedical Research Institute
Rigby, Wendy (21 July 2016). "San Antonio On Front Lines Of AIDS Vaccine Research". Texas Public Radio. Rigby, Wendy (21 August ... and vaccine development. Developing an animal model to test vaccines to protect people against the Zika virus. On April 14, ... Developed vaccines, antibodies and antitoxins for deadly agents of bioterrorism such as Ebola, botulinum neurotoxins, and ... Developing vaccine strategies for Ebola, HIV, Lassa virus, West Nile virus, Japanese encephalitis viruses, and herpes. ...
List of Puerto Rican scientists and inventors
She also served as Coordinator for AIDS Research for NICHD from September 1987. In this role, she developed a particular ... dedicated his life to researching tropical allergies and developing vaccines that would effectively prevent or minimize ... On March 9, 2007, Solís performed, in the "Hospital Auxilio Mutuo" (Mutual Aid Hospital), the first simultaneous pancreas and ... Mutual Aid Hospital). His book, "Organ transplantation", the first to be published in Spanish on the topic, won the Prize of ...
Trimeric autotransporter adhesin
The trimerisation aids translocation, and no translocation would occur without its beta-barrel membrane anchor. The type V ... 2002). "NadA, a novel vaccine candidate of Neisseria meningitidis". J Exp Med. 195 (11): 1445-54. doi:10.1084/jem.20020407. PMC ... The function of the ESPR is to aid inner membrane translocation by acting as a temporary tether. This prevents the accumulation ... Function: The function of the membrane anchor domain is to aid the movement of the polypeptide chain through the cell membrane ...
History of the hippie movement
Their early escapades were chronicled by Tom Wolfe in The Electric Kool-Aid Acid Test. Ken Kesey and the Merry Pranksters are ... MD, Frances R. Frankenburg (16 January 2017). Human Medical Experimentation: From Smallpox Vaccines to Secret Government ... ISBN 0-7876-5417-5. Bryan (1968-08-18). "'The Pump House Gang' and 'The Electric Kool-Aid Acid Test'". Books. The New York ... Therefore, they made LSD available to anyone interested in partaking - most famously through the "electric kool-aid" made ...
Jakob Segal
... published a 47-page pamphlet titled AIDS-Its Nature and Origin, in which they speculated that AIDS was the creation of the U.S ... He also supported the idea of a p24- vaccine without gp120 which was patented by Jonas Salk as "Remune". Jakob Segal/Lilli ... AIDS can be conquered, Verlag Neuer Weg 1995/2001, ISBN 3-88021-296-1 Jakob Segal: AIDS Zellphysiologie Pathologie und Therapie ... Ähnlichkeit von Aids und Visna Report by Jakob Segal about the origin of AIDS (published by monochrom in 1993; German language ...
2022 in the United States
"Covid vaccines for children under 5: CDC director endorses Covid vaccines for babies, toddlers". NBC News. Sewell Chan; Eric ... May 12 - The United States Senate seeks to pass a bill of bipartisan support on sorely needed aid to Ukraine in the Russo- ... March 24 - In New York City, Mayor Eric Adams lifts the vaccine mandate for unvaccinated athletes from teams like the New York ... The United States Senate passes another US$40 billion in aid to Ukraine. A shooting near Chicago's Magnificent Mile kills two ...
Ngozi Okonjo-Iweala
Friends of The Global Fund Africa officially launched Archived 9 May 2020 at the Wayback Machine Global Fund to Fight AIDS, ... In July 2021, she joined the Multilateral Leaders Task Force on COVID-19 Vaccines, Therapeutics, and Diagnostics for Developing ... Okonjo-Iweala, Ngozi (June 2007). Aid versus trade (TED Talk). Archived from the original on 17 February 2021. Okonjo-Iweala, ... "WTO Director-General Ngozi Okonjo-Iweala Discusses Vaccines". The World: Public Radio. Retrieved 24 June 2021. "Prince William ...
WhizzKids United
Bruce Walker of Harvard Medical School, one of the world's leading HIV/AIDS researchers. Boston Red Sox Owner John Henry ... http://harvardmagazine.com/extras/life-on-the-soccer-field WhizzKids United: From HIV Vaccine Development to Soccer. http://www ... WhizzKids United is a youth HIV / AIDS prevention, care, treatment and support programme that uses football as an educational ... The programme recognises the gendered nature of HIV/AIDS in South Africa and as such includes gender equality as a central ...
Current Trends Hepatitis B Vaccine: Evidence Confirming Lack of
AIDS Transmission
In addition, the rate of AIDS for HB vaccine recipients in CDC vaccine trials among homosexually active men in Denver and San ... In addition, epidemiologic monitoring of AIDS cases and high-risk groups confirms the lack of AIDS transmission by HB vaccine. ... Epidemiologic approaches to detect an association between HB vaccine and AIDS have included analysis of data on AIDS cases ... AIDS. The effect of the HB vaccine inactivation process on the AIDS virus and two other human retroviruses (HTLV-I and HTLV-II ...
Browsing by Subject "AIDS Vaccines"
African AIDS Vaccine Programme. Forum (3rd : 2005 : Yaoundé, Cameroon); WHO Initiative for Vaccine Research; UNAIDS (World ... African AIDS Vaccine Programme. Forum (2nd : 2003 : Addis Ababa, Ethiopia); WHO Initiative for Vaccine Research; UNAIDS ( ... Accelerating the global effort for HIV vaccine research : report of the third Forum of the African AIDS Vaccine Programme, ... Scientific and ethical issues in AIDS vaccines Bloom, Barry R.; Macklin, R.; Natth, B. (World Health Organization, 1998-11) ...
Hepatitis B Vaccine: Confirming Lack of AIDS Transmission
Current Trends Hepatitis B Vaccine: Evidence Confirming Lack of AIDS Transmission ... In addition, the rate of AIDS for HB vaccine recipients in CDC vaccine trials among homosexually active men in Denver and San ... In addition, epidemiologic monitoring of AIDS cases and high-risk groups confirms the lack of AIDS transmission by HB vaccine. ... Epidemiologic approaches to detect an association between HB vaccine and AIDS have included analysis of data on AIDS cases ...
Browsing Publications by Author "African AIDS Vaccine Programme. Forum (2nd : 2003 : Addis Ababa, Ethiopia)"
African AIDS Vaccine Programme. Forum (2nd : 2003 : Addis Ababa, Ethiopia); WHO Initiative for Vaccine Research; UNAIDS ( ... Browsing Publications by Author "African AIDS Vaccine Programme. Forum (2nd : 2003 : Addis Ababa, Ethiopia)". 0-9. A. B. C. D ... report of the WHO-UNAIDS sponsored second Forum of the African AIDS Vaccine Programme (AAVP) ... Strategies for the development of HIV vaccine trial sites in Africa : challenges and opportunities : ...
AIDS Vaccine Development: Challenges and Opportunities - Volume 13, Number 11-November 2007 - Emerging Infectious Diseases...
Global HIV Vaccine Enterprise, the Partnership for AIDS Vaccine Evaluation, and the Center for HIV-AIDS Vaccine Immunology). ... AIDS Vaccine Development: Challenges and Opportunities. Emerging Infectious Diseases. 2007;13(11):1802. doi:10.3201/ ... Chen, R. T. (2007). AIDS Vaccine Development: Challenges and Opportunities. Emerging Infectious Diseases, 13(11), 1802. https ... AIDS Vaccine Development: Challenges and Opportunities. Volume 13, Number 11-November 2007 ...
Petition · UK to immediately send Covid Aid and Vaccines to Nepal · Change.org
Discovery Of Two Antibodies Could Move AIDS Vaccine Development Forward | KFF
... many strains of the AIDS virus, a discovery that might help create a long-sought vaccine against the deadly disease, Bloomberg ... potentially better target on HIV to focus our efforts for vaccine design," said Wayne Koff of the International AIDS Vaccine ... The findings themselves are an exciting advance toward the goal of an effective AIDS vaccine because now weve got a new, ... Discovery Of Two Antibodies Could Move AIDS Vaccine Development Forward. Sep 04, 2009 ...
UPS Aids in COVID-19 Vaccine Delivery - UPS Healthcare™ - Belgium
A look into the planning and teamwork that went into safely delivering the first COVID-19 vaccines across the US during the ... As it became apparent that the Pfizer-BioNTech vaccine stood the best chance of being the first vaccine to gain approval from ... "Vaccine distribution is a key part of moving our world forward by delivering what matters," Carol said. "We have dedicated and ... UPS Healthcares humanitarian aid to Malawi shows skill, will and a good heart beneath it all.. Read More ...
How Often Should Cats With FIV/Feline AIDS Receive Vaccines? - Catster
Avoid non-core vaccines such as Bordetella and ringworm.. *Ask that no modified live vaccines be used in your cat. In my ... Some vaccines are made from attenuated (modified) live pathogens. The organisms in these vaccines can in rare instances revert ... Re-vaccinate at one year of age, and then repeat the vaccines no more often than every three years. Core vaccines include ... Feline immunodeficiency virus, or FIV, is very similar to the virus that causes human AIDS. There is no evidence that FIV poses ...
Polio vaccine-AIDS theory dead | The Scientist Magazine®
Polio vaccine-AIDS theory dead. Study finds that Kisangani chimpanzees contain a virus unrelated to HIV-1. David Secko([email protected] ... The OPV/AIDS theory holds that chimpanzees from the Kisangani (previously Stanleyville) area in the Democratic Republic of ... crossed into humans as a result of contamination of oral polio vaccine (OPV), according to a new study. In the April 22 Nature ...
Hepatitis A Vaccine | Hepatitis A Immunization | Rite Aid
What AIDS Taught Coronavirus Leaders: You Can't Bank on a Fast Vaccine - WSJ
What AIDS Taught Coronavirus Leaders: You Cant Bank on a Fast Vaccine. ... And the most influential doctor in the U.S. today would devote his career to HIV and AIDS-training for another virus that would ... https://www.wsj.com/articles/what-the-doctors-leading-the-way-on-coronavirus-learned-from-aids-11586354416 ...
Federal vaccine aid could leave Memphis due to low demand for shots
AIDS research Canadian lab gets OK to test vaccine - Winnipeg Free Press
AIDS research Canadian lab gets OK to test vaccine By: Sheryl Ubelacker Posted: 1:00 AM CST Wednesday, Dec. 21, 2011. ... If the SAV001 vaccine is found to be safe, it would require two more clinical trials that prove it works before it could be ... To make the vaccine, the researchers start by altering the genetic makeup of the human immunodeficiency virus to make it non- ... The SAV001 vaccine, developed by Dr. Chil-Yong Kangs lab with financial support from Sumagen Canada, has been shown to ...
Trust, transparency aided COVID-19 vaccine partnership
... how the firm worked with Moderna on patient recruitment strategy and other solutions in the road to launching a vaccine. ... Trust, transparency aided COVID-19 vaccine partnership: Praxis. By Jenni Spinner ... Related tags: Moderna, COVID-19, Coronavirus, Patient recruitment, Clinical trials, Vaccine A leader from Praxis explains how ... OSP: Could you please describe how your company and Moderna got to collaborate on the COVID-19 vaccine? What were early ...
Private Demand for a HIV/AIDS Vaccine: Evidence from Guadalajara, Mexico | RTI
Evaluating New Approaches to Developing AIDS Vaccines by Creating Virus-like Particles that Display HIV Antigens or by Using...
If an AIDS vaccine could elicit antibodies of this type, it might protect people from the many different circulating varieties ... Evaluating New Approaches to Developing AIDS Vaccines by Creating Virus-like Particles that Display HIV Antigens or by Using ... Evaluating New Approaches to Developing AIDS Vaccines by Creating Virus-like Particles that Display HIV Antigens or by Using ... These studies provide new scientific insight and tools for developing and evaluating vaccines for HIV/AIDS. The experience with ...
New vector and vaccine platforms: mRNA, DNA, viral vectors : Current Opinion in HIV and AIDS
ChAdOx1\r, clinical trials\r, DNA vaccines\r, HIV cure\r, HIV prevention\r, RNA vaccines\r, subunit genetic vaccines. ... Vaccine licensed for use in the United States. 2022. https://www.fda.gov/vaccines-blood-biologics/vaccines/vaccines-licensed- ... ChAdOx1; clinical trials; DNA vaccines; HIV cure; HIV prevention; RNA vaccines; subunit genetic vaccines ... New vector and vaccine platforms: mRNA, DNA, viral vectors : Current Opinion in HIV and AIDS. ...
01: Back to the beginning: AIDS and the elusive vaccine | International AIDS Society (IAS)
Within two years, the virus that causes AIDS was discovered, spurring hopes for a vaccine. But a vaccine has proven to be ... Udom Likhitwonnawut is a member of the Vaccine Advocacy Resource Group (VARG) and has been a consultant for AIDS Vaccine ... Gregg Gonsalves: Back then it was, who had AIDS drugs? And now, who has a COVID vaccine is the new apartheid in the medical ... Home , HIV unmuted podcast , #01: Back to the beginning: AIDS and the elusive vaccine ...
Free and Low- Cost Vaccine and Care Clinics for Pets - AIDS Action
For $10 the Waggin offers a physical exam, rabies vaccine, distemper vaccine, Flea treatment and microchip for cats and dogs. ... Free and Low- Cost Vaccine and Care Clinics for Pets. By Charlotte Grossman. August 12, 2021 Resources ... Dog Licensing and Low-Cost Vaccine Clinic for Pets Twice a month from 10:00-2:00 on Saturdays Animal Care and Control is ... Clinics include low cost or free dog licensing, rabies and distemper vaccines for $5 dollars and free microchipping. No ...
Mr. President, There Is No AIDS Vaccine - Health GAP (Global Access Project)
Rite Aid, CVS, Walgreens to offer COVID vaccine for kids under 12
Gene work could aid vaccines, cancer therapy | MIT News | Massachusetts Institute of Technology
... we might have more effective vaccines for a variety of diseases, including AIDS." ... "BCG vaccines have a long record of safe use, but their reported efficacy varies tremendously," said Dr. Murray, the Whitehead ... "Depending on the vaccine trial, efficacy figures range from 0 to 80 percent. Such variability, combined with the increase in ... The Whitehead scientists will also begin to hone in on the ideal genetic make-up of an improved TB vaccine for human beings. ...
HIV/AIDS vaccine and cure: American Gene Technologies | 5newsonline.com
We can be donating our time to HIV/AIDS organizations. We can be lobbying the Red Cross to lift their ban on gay men not being ... There have been promises of a cure since the first cases of what would later be known as HIV/AIDS.. The Centers for Disease ... "My hope is that people realize the seriousness of HIV, but that people are living with HIV and not dying as much from AIDS ... RELATED: It felt like being in a war , First AIDS cases reported 40 years ago ...
New Findings in Humans Provide Encouraging Foundation for Upcoming AIDS Vaccine Clinical Trial
This method is a valuable tool in the design of more targeted and effective vaccines against AIDS, providing the ability to vet ... The findings by scientists from The Scripps Research Institute (TSRI), the International AIDS Vaccine Initiative (IAVI) and the ... This work was supported by the International AIDS Vaccine Initiative Neutralizing Antibody Consortium and Center; the Ragon ... New Findings in Humans Provide Encouraging Foundation for Upcoming AIDS Vaccine Clinical Trial. ...
Australia to send 2.5 million AstraZeneca vaccine doses to Indonesia and offers emergency aid as COVID-19 crisis deepens - ABC...
Australia will dip into its domestic vaccine stockpile and rush medical supplies to Indonesia as the country grapples with a ... Australia to send 2.5 million AstraZeneca vaccine doses to Indonesia and offers emergency aid as COVID-19 crisis deepens. By ... Archie Law, from aid agency Save the Children, said the situation in Indonesia may eventually require a response like that ... The 2.5 million AstraZeneca vaccine doses pledged by Senator Payne will be drawn from the 20 million doses Prime Minister Scott ...
covid-vaccine-facts-logo-trans - Ontario Association of Children's Aid Societies
News Brief: Vaccine Vote, Lawsuits Against Facebook, Relief Aid Debate | KUER
The FDA will vote on whether to clear Pfizers COVID-19 vaccine for emergency use. Two lawsuits question how Facebook got so ... HORSLEY: Aid to state and local governments also provides a lot of bang for the buck; grants to small businesses, probably less ... Experts are going to weigh the benefits and the risks of clearing Pfizers COVID-19 vaccine for emergency use in the U.S. Now, ... The FDA has built a case that this vaccine should be authorized for emergency use. Now, the meeting starts at 9 a.m. Eastern ...
Advances from Animal Research: AIDS and Zika Vaccines Update - Speaking of Research
... two other developments focusing on treatments for AIDS and Zika fever have caught our eye. These fall under the topic #MPAR, ... 2021Professor Christopher Petkov Although we have been focusing on updates on Covid-19 vaccines and their reliance on research ... by EditorPosted in News, Science NewsTagged #AnimalResearchSavesLives, #MPAR, #timescales, aids, hiv, SIV, vaccine, zika. Post ... Advances from Animal Research: AIDS and Zika Vaccines Update. April 19th, 2021. Professor Christopher Petkov ...
EN (en)
Vaccine approaches against AIDS have focused on inducing cellular immune responses, since many studies revealed the role of T ... After preclinical evaluations, DNA has entered clinical trials for a therapeutic or prophylactic gene-based AIDS vaccine. ... The experimental infection of rhesus macaques with SIV or chimeric SHIV is routinely used as a model for AIDS. In such models, ... High level of Bcl-2 counteracts apoptosis mediated by a live rabies virus vaccine strain and induces long-term infection ...
COVIDDosesVaccinationAntibodiesCoronavirusAfrican AIDS Vaccine ProgrammeInternational AIDS VacciClinicalDiseases20222021InfectionProgrammeReceive the vaccineLive attenuatedModernaPfizer-BioNTechDrugs and VaccinesPolio vaccineGlobal HIV Vaccine EnterpriseAntigensEpidemicRite AidSouth AfricaImmunogenicityPreventionTuberculosisEfficacy trialsSubunit vaccinesIterative vaccineUNAIDSTrials NetworkImmunisationDoseRecombinant vaccinesImmune systemResearchersViralDevelopmentAntibodyPandemicPreventiveUptakeOperation Warp SpeedGeneticHepatitisHuman papillomavirusProteinsImmunogensProteinHesitancyRemains an elusive goalGloballyCandidatesAdjuvantScientistsSafeApproaches
COVID79
- We owe the Nepalese people and the Ghurkas who have sacrificed themselves, fighting alongside the UK for decades in the name of our freedom the aid they need to help their people fight off COVID-19. (change.org)
- Invited to be part of the planning of Operation Warp Speed , UPS was at the table as logistical scenarios were developed while public/private partnerships raced to develop and test effective COVID-19 vaccines. (ups.com)
- Reggie in Ann Arbor, ironically only about 90 minutes from one of the vaccine production facilities, was now, finally, making one of the first deliveries of a vaccine that could end the scourge of COVID-19 illnesses and deaths. (ups.com)
- Tricia Barrett, senior vice president and managing director for Praxis, is one of the two presenters (the other Diane Montross, senior director of patient recruitment and retention at Moderna) for Operation Warp Speed: Recruitment and Retention, Launching a Recruitment Strategy for a Phase III COVID-19 Vaccine Trial, taking place online Tuesday, March 2 at 2:20 pm EST. (outsourcing-pharma.com)
- OSP: Could you please describe how your company and Moderna got to collaborate on the COVID-19 vaccine? (outsourcing-pharma.com)
- TB: Diane Montross, who joined Moderna in June 2020 as their senior director of patient recruitment and retention, invited us to collaborate on their Phase III COVID-19 vaccine trial. (outsourcing-pharma.com)
- The focus is on HIV-1/AIDS with reference to the most successful as well as currently tested COVID-19 vaccines, and human trials, which best inform iterative vaccine improvements. (lww.com)
- Intensive research into HIV-1 vaccines is entering its fifth decade, although with fewer than 10 funded phase 3 trials testing preventive efficacy of candidate vaccines since the start of the AIDS epidemic (compared with nine licensed vaccines and over three dozen vaccine efficacy trials in the first 2 years of the COVID-19 pandemic [2] ). (lww.com)
- Indonesia appreciates Australia's offer of vaccines, ventilators & oxygen-related supplies to deal with the latest surge of COVID-19,' she said on social media. (abc.net.au)
- Experts are going to weigh the benefits and the risks of clearing Pfizer's COVID-19 vaccine for emergency use in the U.S. Now, depending on how this meeting goes, we could know soon when our vaccination program is going to start. (kuer.org)
- Although we have been focusing on updates on Covid-19 vaccines and their reliance on research with nonhuman animals including primates (as an example post see here ), two other developments focusing on treatments for AIDS and Zika fever have caught our eye. (speakingofresearch.com)
- The OECD's Development Assistance Committee (DAC) is facing an impasse among its membership on the adoption of controversial new rules that would allow rich countries to report the donation of surplus Covid-19 vaccines as aid. (eurodad.org)
- 21 June, Istanbul - World Vision, International Blue Crescent Relief and Development Foundation (IBC) and the Research Centre on Asylum and Migration (IGAM) together with other local actors meet today to discuss equal access to COVID-19 vaccines for Syrian refugees in Turkey. (wvi.org)
- Families who are most ravaged by COVID-19 continue to have the least access to vaccines - and many who have the power to change this are looking on. (wvi.org)
- IBC implements awareness-raising sessions to beneficiaries about appointment processes for the vaccine and the importance of the Covid-19 measurements. (wvi.org)
- Doses of Moderna's COVID-19 vaccine are prepared at the Liacouras Center, where the Black Doctors Consortium held a 24-hour mass vaccination clinic on Feb. 19, 2021. (whyy.org)
- Ask us about COVID-19: What questions do you have about the coronavirus and vaccines? (whyy.org)
- As of last week, all of Pennsylvania's skilled nursing facilities participating in the federal Pharmacy Partnership for Long-Term Care Program have completed their first dose COVID-19 vaccine clinics. (whyy.org)
- CONCORD, N.H - New Hampshire is getting nearly $30.7 million in additional federal money to support COVID-19 vaccines to correct a CDC formula that previously shortchanged small states. (thenationalherald.com)
- A vaccine that uses messenger RNA technology, the same one found in some COVID-19 vaccines, but this time against AIDS, has shown promising first results in animals, researchers said. (vaughantoday.ca)
- Scientists from this institute conducted this work in collaboration with researchers from the US company Moderna, which is behind one of the most widely used vaccines against COVID-19. (vaughantoday.ca)
- Rite Aid announced Friday that it is now taking walk-in customers for a COVID-19 vaccination shot at all 129 of its New Jersey locations. (roi-nj.com)
- The availability of vaccines in every Rite Aid location is a major milestone in our ongoing effort to fight COVID-19," he said. (roi-nj.com)
- Also, in addition to the grassroots efforts we've undertaken with our community partners, the availability of these walk-in appointments provides another way for those with limited or no technology access to more easily obtain COVID vaccines. (roi-nj.com)
- Individuals ages 18 and over can schedule appointments using the Rite Aid scheduling tool found at www.RiteAid.com/covid-19 . (roi-nj.com)
- 1 year ) it took to advance from sequencing SARS-CoV-2 to producing enough candidate modRNA/spike protein vaccine for large (30,000 volunteer) clinical trials, as well as hundreds of millions of doses of the two currently approved vaccines for COVID-19 by Pfizer/BioNTech (illustrated here) and Moderna. (trilinkbiotech.com)
- 3D illustration of the Pfizer/BioNTech vaccine for COVID-19 on the production line. (trilinkbiotech.com)
- The flood of COVID-relief aid -- $5.2 trillion in all -- that Congress approved in 2020 and 2021 under Republican President Donald Trump and his Democratic successor Joe Biden has emerged as an early target for House of Representatives Republicans as they search for ways to rein in federal spending. (medscape.com)
- But unspent COVID aid is a small target, with less than $80 billion unspent as of January, White House budget figures show. (medscape.com)
- Another $6.8 billion remains to fight the virus itself by developing improved vaccines and tests and researching topics like long COVID, according to the White House. (medscape.com)
- Natural News ) Evidence continues to mount showing that Wuhan coronavirus (Covid-19) "vaccines" are causing recipients everywhere to develop AIDS. (dcclothesline.com)
- Covid-19 Vaccine Induced Acquired Immune Deficiency Syndrome, or VAIDS , appears to be one of the more serious long-term adverse effects caused by the injections. (dcclothesline.com)
- A vaccine effectiveness of +50% would mean that the fully vaccinated are 50% more protected against Covid-19 than the unvaccinated," reported the Daily Exposé . (dcclothesline.com)
- Therefore, the Covid-19 vaccines have damaged the immune system. (dcclothesline.com)
- The lowest Covid-19 vaccine effectiveness was seen in the 40-49 age group in England throughout January 2022, recorded at minus-209.4%, with the 50-59 age group not far behind," it was determined. (dcclothesline.com)
- Real world Covid-19 vaccine effectiveness against death in England between 3rd Jan and 30th Jan 22 was as low as -110.24% in the over 80's, -97% in people aged 70-79, and -98.14% on average in all adults over age 18," the Exposé reports. (dcclothesline.com)
- More related news about Wuhan coronavirus (Covid-19) "vaccines" can be found at ChemicalViolence.com . (dcclothesline.com)
- Doses of the Oxford-AstraZeneca Covid-19 vaccine are going unused across the EU amid low confidence in the jab after the company was repeatedly criticized by Brussels for not sharing sufficient data and supply problems. (rt.com)
- Rite Aid offers painless Rite Aid Covid Testing at most of the Drive-Thru test locations. (nufo.org)
- First, take the Rite Aid Covid Testing kit from the drive-through window, Open the wrapper of the swab & place the swab midway in your nose rotate or circle twice then hold your nose for 15 seconds, and repeat the same steps with the same swab in the other nostril. (nufo.org)
- How to book an appointment for Rite Aid Covid Testing Through Drive Thro? (nufo.org)
- All Rite-Aid COVID 19 tests are free and available for ages 4 and up, but reservations are required to take the test. (nufo.org)
- The Biden administration made direct payments to nearly all major corporate media outlets to deploy a $1 billion taxpayer-funded outreach campaign designed to push only positive coverage about COVID-19 vaccines and to censor any negative coverage, according to documents obtained by The Blaze. (ca1776.com)
- The ad campaigns were timed in conjunction with the increased availability of COVID vaccines. (ca1776.com)
- BuzzFeed News advised everyone age 65 or older, people with health conditions that put them at high risk of severe illness from COVID, healthcare workers and those at high risk of exposure to the virus to get vaccine boosters , in accordance with guidance from the Centers for Disease Control and Prevention (CDC). (ca1776.com)
- Newsmax said COVID vaccines have "been demonstrated to be safe and effective" and "encouraged citizens, especially those at risk, to get immunized. (ca1776.com)
- Yet, the latest data from the CDC's Vaccine Adverse Event Reporting System shows 1,151,450 reports of adverse events from all age groups following COVID vaccines, including 24,827 deaths since Dec. 14, 2020. (ca1776.com)
- Numerous scientists and public health experts have questioned the safety and efficacy of COVID vaccines, as well as the data underlying the U.S. Food and Drug Administration's authorization of the shots. (ca1776.com)
- The media rarely covered negative news stories about COVID vaccines, and some have labeled anyone who questions the shots " science denialists " or " conspiracy theorists . (ca1776.com)
- CBS 58) -- The Washington County Public Health Department hosted its last COVID-19 vaccine clinic Thursday morning, June 3. (cbs58.com)
- Health leaders say COVID-19 cases are down and vaccine demand is dropping so they feel comfortable shutting down the clinic. (cbs58.com)
- To start your search for a COVID-19 vaccine, CLICK HERE . (cbs58.com)
- An experimental HIV vaccine based on mRNA-the same platform technology used in two highly effective COVID-19 vaccines-shows promise in mice and non-human primates, according to scientists at the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health. (nih.gov)
- The experimental vaccine works like mRNA COVID-19 vaccines. (nih.gov)
- Late last year, the Pfizer and Moderna COVID vaccines jabs were both licensed for emergency use only by the U.S. Food and Drug Administration (FDA). (swfinstitute.org)
- The COVID mRNA vaccine partly works by inducing local inflammatory reactions to trigger the immune system. (swfinstitute.org)
- The country received its first shipment of COVID-19 vaccine doses in July. (wypr.org)
- One week after Haiti's president was assassinated, the country's first shipment of COVID-19 vaccines finally arrived. (wypr.org)
- He is a veteran physician who has been on the front lines of Haiti's HIV/AIDS crisis and co-leads the country's efforts against COVID-19. (wypr.org)
- A case in point is the Novavax COVID-19 vaccine manufactured by Novavax, a biotechnology firm from Maryland. (legalreader.com)
- About 80% of Americans have had their first dose of the COVID-19 vaccine, and two-thirds have completed both rounds. (legalreader.com)
- Should you get a COVID-19 vaccine? (health.mil)
- As the COVID-19 vaccines continue to be administered across military hospitals and smaller clinics and outposts under Centers for Disease Control and Prevention guidance, the advice from the military and a multitude of national maternal and fetal health professional associations is the same: For most pregnant people, getting the COVID-19 vaccine as soon as possible is the safest choice based on the science to date. (health.mil)
- The COVID-19 vaccines made by Pfizer and Moderna are mRNA vaccines. (health.mil)
- As COVID-19 vaccines were being developed, studies in the laboratory and animals showed no reproductive health problems," Ryan added. (health.mil)
- Pregnant people are entering clinical trials for COVID-19 vaccines "literally now and going into March, so more data will be known soon," Dr. Anthony Fauci, President Joe Biden's chief medical adviser on COVID-19, told a Blue Star Families virtual town hall Feb. 4. (health.mil)
- Many who are pregnant are health care providers who said the risk of getting COVID-19 from their patients was worse than that from getting the vaccine," said Fauci, director of the National Institute of Allergy and Infectious Diseases at the National Institutes of Health. (health.mil)
- As for those who do not want to take the vaccine, "we know there are significantly increased risks for pregnant people who contract COVID-19, e.g., they are three times more likely to be admitted to the ICU and need breathing support," said Navy Cmdr. (health.mil)
- Ryan went on to say that specialists from the CDC, American College of Obstetrics and Gynecology, and American Academy of Breastfeeding Medicine "all agree that breastfeeding should not be a barrier to receipt of a COVID-19 vaccine. (health.mil)
- Introduction: as the coronavirus disease 2019 (COVID-19) vaccines are distributed and administered globally, hesitancy towards the vaccine hinders the immunisation of a significant number of vulnerable populations, such as people living with HIV/AIDS. (bvsalud.org)
- Hence, this study aims to assess COVID-19 vaccine hesitancy among people living with HIV/AIDS (PLHIV) attending clinicaloutpatient follow-up at State Specialist Hospital Maiduguri (SSHM), Borno State, Nigeria. (bvsalud.org)
- Methods: a hospital-based cross-sectional study design was conducted to assess COVID-19 vaccine hesitancy among 344 PLHIV receiving antiretroviral therapy (ART) at the United States President´s Emergency Plan for AIDS (PEPFAR) clinic in SSHM from 4 th January to 25th February 2022. (bvsalud.org)
- The factors that are associated with COVID-19 vaccine hesitancy were identified using the Chi-square statistical test. (bvsalud.org)
- Results: among the 344 respondents of the study, only 88 (26.6%) received the COVID-19 vaccine. (bvsalud.org)
- Conclusion: hesitancy towards COVID-19 vaccine is high among PLHIV and there is no any statistically significant association between COVID-19 vaccine hesitancy and the independent variables of the study where p-value is greater than 0.05. (bvsalud.org)
- The CDC updated COVID-19 vaccine recommendations for vaccination in April 2023 to simplify and allow flexibility for people at higher risk. (medscape.com)
- The FDA Vaccines and Related Biological Products Advisory Committee (VRBPAC) continues to assess the optimal composition of COVID-19 primary and booster vaccines. (medscape.com)
- It provides the number of bivalent mRNA vaccine doses an individual needs based on COVID-19 vaccine doses previously received, including the number of prior doses, whether the doses were monovalent or bivalent, and the vaccine manufacturer (Moderna, Novavax, or Pfizer-BioNTech). (medscape.com)
- It supports research to identify potential vaccines for a variety of emerging infectious diseases, including COVID-19, Zika virus, and HIV/AIDS. (medlineplus.gov)
Doses13
- Several genetic subunit vaccines against SARS-CoV-2 demonstrated protection against severe disease, obtained Emergency Use Authorization and scaled their production to billions of doses. (lww.com)
- The Federal Government has also promised to send Indonesia 2.5 million AstraZeneca vaccine doses this year, drawn from Australia's domestic stockpile. (abc.net.au)
- HARRIS: And if there is a quick decision, the first doses of this vaccine could get into people's arms within days. (kuer.org)
- Secondly, we have not seen any mechanism to ensure that DAC members do not report more than the original cost of the vaccine doses they are donating as ODA (that would be the case for example with the surplus donation of Astrazeneca doses which cost less than the $6.72 price tag). (eurodad.org)
- They have access to only three per cent of global vaccine doses. (wvi.org)
- Overall, more than 150,000 doses of the vaccine have been administered to residents of these facilities, and 140,000 doses were administered to staff members. (whyy.org)
- Thursday's clinic was strictly for second doses, or walk-ins for the Johnson & Johnson vaccine. (cbs58.com)
- Although the doses of mRNA delivered were high, the vaccine was well tolerated and produced only mild, temporary adverse effects in the macaques, such as loss of appetite. (nih.gov)
- Earlier this year, Haiti shrugged off two offers of doses AstraZeneca - first from India and then from COVAX, the global vaccine sharing program . (wypr.org)
- And in mid-July, the U.S. sent half a million doses of the Moderna vaccine through COVAX to the Caribbean nation. (wypr.org)
- While the announcement of a commitment of a $1 billion-worth of vaccine doses also hit headlines, the overall sentiment seemed to be: We knew the Africa-China relationship would begin to deteriorate! (wita.org)
- First, while China is already the largest supplier of vaccine doses to African countries, having sent 200 million doses to date, now China could become Africa's largest vaccine donor, with a commitment to donate $600 million doses and locally manufacture $400 million doses with partners on the continent. (wita.org)
- Most people aged ≥ 6 years who are not moderately or severely immunocompromised and have received 1 dose of a bivalent mRNA vaccine (from either Moderna or Pfizer ) do not need any further vaccine doses as of April 2023. (medscape.com)
Vaccination14
- Although some thoughtful and reasonable veterinarians may disagree with this (remember, there is no consensus among vets about vaccines in general), I recommend that you follow standard kitten vaccination guidelines for core vaccines. (catster.com)
- This would allow proper planning of any vaccination campaign and to understand whether vaccines donated are reaching the final beneficiaries in developing countries. (eurodad.org)
- This makes the optimal age for vaccination even younger, since adolescents should ideally receive a preventive AIDS vaccine before they become sexually active. (vaxreport.org)
- Results from HPV and HBV vaccine trials also give researchers good reason to be optimistic that adolescents may respond even better to vaccination than adults. (vaxreport.org)
- However, given the need for potent cross-clade humoral and T-cell immunity for protection against HIV, and the uncertainty surrounding the efficacy of protein subunit vaccines, it is most likely that plant-made HIV vaccines will find their niche as booster immunizations in prime-boost vaccination schedules. (edu.au)
- discuss the history of polio globally and the United States, outline the current investigation and response to the case of paralytic polio New York, describe how to recognize, diagnose, and report suspected paralytic polio cases in the United States, and distinguish the differences between inactivated polio vaccine and oral polio vaccine and the importance of maintaining high polio vaccination coverage. (cdc.gov)
- understand the history of polio in the U.S. and globally, describe polioviruses, understand the incubation period and transmission of poliovirus, and understand the impact of polio vaccination and the different types of vaccine. (cdc.gov)
- CDC recommends annual influenza vaccination for everyone 6 months and older with any flu vaccine licensed by the Food and Drug Administration (FDA) that is appropriate for the recipient's age and health status. (cdc.gov)
- Should pro-vaccine parents engage in the anti-vaccination debate? (vaccinestoday.eu)
- Defining surrogate serologic tests with respect to predicting protective vaccine efficacy: Poliovirus vaccination. (who.int)
- Initial data with showed effectiveness of full vaccination with monoclonal vaccines in older adults to prevent hospitalization was estimated for the period between February through April 2021. (medscape.com)
- During its February 2015 meeting, the Advisory Committee on Immunization Practices (ACIP) recommended 9-valent human papillomavirus (HPV) vaccine (9vHPV) (Gardasil 9, Merck and Co., Inc.) as one of three HPV vaccines that can be used for routine vaccination ( Table 1 ). (cdc.gov)
- HPV vaccine is recommended for routine vaccination at age 11 or 12 years ( 1 ). (cdc.gov)
- This report summarizes evidence considered by ACIP in recommending 9vHPV as one of three HPV vaccines that can be used for vaccination and provides recommendations for vaccine use. (cdc.gov)
Antibodies14
- The third approach attempted to detect seroconversion to AIDS virus antibodies in paired sera of HB vaccine recipients. (cdc.gov)
- Scientists from Scripps Research Institute on Thursday announced they have discovered and isolated two antibodies "with the ability to neutralize [or block the action of] many strains of the AIDS virus, a discovery that might help create a long-sought vaccine against the deadly disease," Bloomberg reports. (kff.org)
- Though "[t]he antibodies are produced naturally by a minority of people infected with HIV," scientists "believe they can create an effective vaccine if they are able to stimulate the body to produce such … antibodies before exposure to HIV," Agence France-Presse writes (9/3). (kff.org)
- Researchers now have to work out how these antibodies bind to HIV, the virus that causes AIDS, and use that property as the basis for a vaccine. (kff.org)
- If an AIDS vaccine could elicit antibodies of this type, it might protect people from the many different circulating varieties of HIV. (fda.gov)
- Some people infected with HIV naturally produce antibodies that effectively neutralize many strains of the rapidly mutating virus, and scientists are working to develop a vaccine capable of inducing such "broadly neutralizing" antibodies that can prevent HIV infection. (infectioncontroltoday.com)
- An emerging vaccine strategy involves immunizing people with a series of different engineered HIV proteins as immunogens to teach the immune system to produce broadly neutralizing antibodies against HIV. (infectioncontroltoday.com)
- The scientists noted, however, that the levels of obtained antibodies were relatively low, and that a vaccine that would require multiple injections would be difficult to implement in humans. (vaughantoday.ca)
- indicate that the modRNA-LNP platform could improve the elicitation of neutralizing antibodies against HIV (used herein interchangeably with HIV-1 , the causative agent for AIDS). (trilinkbiotech.com)
- Examining these structures has allowed them to reverse engineer molecules that specifically activate the precursors of effective, neutralizing antibodies against the virus - molecules that may be components of a future vaccine against HIV. (factbuckscounty.org)
- In studies with mice, two injections of the VLP-forming mRNA vaccine induced neutralizing antibodies in all animals, the investigators report. (nih.gov)
- In addition to neutralizing antibodies, the VLP mRNA vaccine also induced a robust helper T-cell response. (nih.gov)
- To design a successful HIV vaccine that elicits protective antibodies and induces long-term protective immunity, we propose integrated efforts focused on three areas. (chavd.org)
- Focus on broadly neutralizing antibodies is strong as they have proven to be protective in robust non-human primate models and because some non-neutralizing antibodies may have protective qualities that might be exploited in vaccine discovery. (chavd.org)
Coronavirus7
- South Korea previously offered to send vaccines and other medical aid to the North to help it deal with its coronavirus outbreak. (koreaherald.com)
- The New York Times has published a coronavirus vaccine tracker that shows the progress of the more than 165 vaccines in development, and the 30 that are in human trials. (mymcmedia.org)
- The coronavirus pandemic has forced researchers to condense years of research and testing into a shorter time frame, with the goal to produce a safe and effective vaccine by 2021. (mymcmedia.org)
- Their vaccine is protein-based, which means it takes a coronavirus protein and uses it to create the immune response. (mymcmedia.org)
- The New York Times says that "in June, the F.D.A. said that a coronavirus vaccine would have to protect at least 50% of vaccinated people to be considered effective. (mymcmedia.org)
- However, instead of carrying mRNA instructions for the coronavirus spike protein, the vaccine delivers coded instructions for making two key HIV proteins, Env and Gag. (nih.gov)
- Republicans who run the Legislature's budget committee used a forum with Wisconsin's superintendent of schools Tuesday to criticize federal school aid payments during the coronavirus pandemic, suggesting it could play a role in the education budget they pass later this year. (urbanmilwaukee.com)
African AIDS Vaccine Programme2
International AIDS Vacci3
- The findings themselves are an exciting advance toward the goal of an effective AIDS vaccine because now we've got a new, potentially better target on HIV to focus our efforts for vaccine design," said Wayne Koff of the International AIDS Vaccine Initiative, the group which sponsored the study, Reuters reports (Fox, 9/3). (kff.org)
- The findings by scientists from The Scripps Research Institute (TSRI), the International AIDS Vaccine Initiative (IAVI) and the La Jolla Institute for Allergy and Immunology were published in Science on March 25. (infectioncontroltoday.com)
- The work was funded by the International AIDS Vaccine Initiative Neutralizing Antibody Center, the Scripps Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery and the National Institute of Allergy and Infectious Diseases (one of the National Institutes of Health). (factbuckscounty.org)
Clinical20
- The editors were careful to include chapters on important nonscientific aspects of HIV vaccine development, such as clinical site development, regulatory issues, scale-up, and manufacturing. (cdc.gov)
- We started planning this back in April when we got involved with the clinical trials (of vaccines)," said Wes. (ups.com)
- FDA approval for human clinical trials is an extremely significant milestone for our vaccine, which has the potential to save the lives of millions of people around the world by preventing HIV infection," said Kang, whose lab has spent 10 years developing the vaccine. (winnipegfreepress.com)
- If the SAV001 vaccine is found to be safe, it would require two more clinical trials that prove it works before it could be brought to market. (winnipegfreepress.com)
- The SAV001 is not the first experimental HIV vaccine to show promise in pre-clinical testing. (winnipegfreepress.com)
- He is a Clinical Associate Professor of Medicine at the David Geffen School of Medicine at the University of California, Los Angeles, and medical advisor to the Elizabeth Taylor AIDS Foundation and the Global AIDS Interfaith Alliance (GAIA). (iasociety.org)
- He has been involved in community engagement for over 18 years, supporting the MUL Masaka research site to conduct a wide range of community-based bio-medical research, including HIV vaccine clinical trials. (iasociety.org)
- Using a new technique, we were able to show-well in advance of clinical trials-that most humans actually have the right B cells that will bind to this vaccine candidate. (infectioncontroltoday.com)
- The work offers encouraging insights for a planned Phase 1 clinical trial to test a nanoparticle version of the engineered HIV vaccine protein, the "eOD-GT8 60mer. (infectioncontroltoday.com)
- This method is a valuable tool in the design of more targeted and effective vaccines against AIDS, providing the ability to vet germline-targeting immunogens before testing them in large, time-consuming and costly clinical trials. (infectioncontroltoday.com)
- This promising improved vaccine may now enter clinical trials for it to be assessed for effectiveness. (speakingofresearch.com)
- After preclinical evaluations, DNA has entered clinical trials for a therapeutic or prophylactic gene-based AIDS vaccine. (pasteur.fr)
- NIH-supported research efforts include two late-stage, multinational vaccine clinical trials called Imbokodo and Mosaico , both key components to the NIAID's approach towards HIV vaccine development . (trilinkbiotech.com)
- We will only pursue development and clinical testing of vaccines that elicit bnAbs under physiological conditions relevant to humans. (chavd.org)
- mRNA vaccines didn't reveal such side effects in clinical tests, but these cases appeared only after administering millions of injections. (legalreader.com)
- HIV researchers around the globe are regrouping after this week's announcement that a promising new vaccine had failed a critical test, shutting down a major clinical trial in South Africa two years before it was scheduled to end. (fredhutch.org)
- Its findings were a surprise when they came out in 2009, because the Thai vaccine was a combination of two vaccine candidates that had failed in prior clinical trials. (fredhutch.org)
- HIV Vaccine Trials Network (HVTN) Executive Director, James Kublin, MD, MPH, lead a one-day training on 3 October 2014, in Harare, aimed at orienting Zimbabwe national regulators to the work of the HVTN, the P5 Initiative in Southern Africa, and Phase I clinical trials the network is planning for implementation in the region. (uz-ctrc.org)
- Globally, at least 12 vaccines are approved for full use, more than 20 vaccines are authorized for early or limited use, and as of Fall 2022, 42 vaccines were in phase 3 clinical trials. (medscape.com)
- From October 2013 to February 2015, the ACIP HPV Vaccine Work Group reviewed clinical trial data assessing the efficacy, immunogenicity, and safety of 9vHPV, modeling data on cost-effectiveness of 9vHPV, and data on burden of type-specific HPV-associated disease in the United States. (cdc.gov)
Diseases17
- The purpose of this review is to share the excitement of new developments in the field of vaccine vector modalities against infectious diseases. (lww.com)
- For more complex diseases such as AIDS, tuberculosis (TB), malaria, cancers, autoimmune and neurodegenerative diseases, vaccine development requires a much greater understanding of the principles and pathways towards effective immunity. (lww.com)
- This achievement could lead to more effective vaccines for a broad range of human diseases and also--because the same organism is used in immunotherapy for bladder cancer--to safer, more effective cancer therapy. (mit.edu)
- The new Whitehead study represents the first systematic effort to determine which mammalian growth factors might be most suitable for a new BCG recombinant vaccine for tuberculosis and other diseases. (mit.edu)
- If we could make these responses stronger, we might have more effective vaccines for a variety of diseases, including AIDS. (mit.edu)
- AIDS makes the person vulnerable to diseases that are otherwise well controlled by the immune system. (speakingofresearch.com)
- This experimental mRNA vaccine combines several features that could overcome the failures of other experimental HIV vaccines, and therefore represents a promising approach," added the director of the US National Institute of Allergy and Infectious Diseases (NIAD). (vaughantoday.ca)
- According to information from the National Institute for Allergies and Infectious Diseases (NIAID), for which Dr. Anthony Fauci serves as Director, HIV (human immunodeficiency virus) causes AIDS (acquired immunodeficiency syndrome) and can be transmitted during sexual intercourse, by sharing syringes, or perinatally during pregnancy, childbirth, or breastfeeding. (trilinkbiotech.com)
- An ongoing dialogue on HIV/AIDS, infectious diseases, all matters medical, and some not so medical. (jwatch.org)
- For most vaccines this is in infants, who are susceptible to many diseases that they would normally catch during early childhood. (vaxreport.org)
- As 2014 draws to a close, one theme that has been continuously present is the importance of a strong public health infrastructure in a country to effectively protect against vaccine-preventable diseases (VPDs). (cdc.gov)
- This scenario had been located in a hypothetical Dixon Tiller County, U.S.A., and was used as a teaching aid regarding the prevention of vaccine preventable diseases. (cdc.gov)
- Gene therapy holds promise for treating a wide range of diseases, such as cancer, cystic fibrosis, heart disease, diabetes, hemophilia and AIDS. (swfinstitute.org)
- August is National Immunization Awareness Month, which brings attention to the value of protecting yourself and your family from vaccine-preventable diseases like chickenpox and the flu. (medlineplus.gov)
- Vaccines help control and sometimes get rid of diseases like measles or polio that in years past sickened or killed many people. (medlineplus.gov)
- Vaccine research is a priority for the National Institute of Allergy and Infectious Diseases. (medlineplus.gov)
- Vaccines help control and sometimes get rid of diseases like measles or polio. (medlineplus.gov)
20225
- AIDS 2022 - Will mRNA technology be able to deliver an HIV vaccine? (univadis.com)
- These FDA-licensed vaccine products are available in the United States for the 2021-2022 flu season. (cdc.gov)
- This is the only LAIV nasal spray vaccine available for use during the 2021-2022 season. (cdc.gov)
- This is the only cell-based inactivated influenza vaccine that has been licensed by the FDA for using during the 2021-2022 flu season. (cdc.gov)
- Taking into account diminished VE, new bivalent mRNA vaccine boosters were authorized in Fall 2022 containing Omicron BA.4/BA.5 components. (medscape.com)
20213
- In March 2021, Congress appropriated $1 billion U.S. tax dollars for the Secretary of Health and Human Services to spend on activities to "strengthen vaccine confidence in the United States," with $3 billion set aside for the CDC to fund "support and outreach efforts" in states through community-based organizations and trusted leaders. (ca1776.com)
- One way to think about this, as evident from our comparison table below, is that in 2018, China effectively put both a target but also an upper limit on aid and loans to African countries at $15 billion - this is the part of the overall 2018 $60 billion commitment that is now "missing" in 2021. (wita.org)
- To commemorate the 33rd World AIDS Day, on December 1, 2021, Treatment Action Group in collaboration with the HIV Vaccine Trials Network, Southern AIDS Coalition, and Black AIDS Institute held this webinar to reflect on the past and celebrate the many successes and innovations in biomedical research that help to shape the prevention landscape for community members, people living with HIV, advocates, and researchers. (cdc.gov)
Infection18
- and (3) look for serologic markers of infection from the AIDS virus in vaccine recipients. (cdc.gov)
- WHO-IFPMA Working Group on the Development, Testing, Utilization and Supply of Drugs and Vaccines for HIV Infection and HIV-related Disease. (who.int)
- TORONTO -- Canadian researchers have been given the green light for human testing of an experimental HIV vaccine, but the initial trial will determine only its safety, not whether it prevents infection. (winnipegfreepress.com)
- The first monkey trials of rubella/Gag vectors showed vaccine potency: antibody titers to the vectors were as high as to natural infection with SIV. (fda.gov)
- The experimental infection of rhesus macaques with SIV or chimeric SHIV is routinely used as a model for AIDS. (pasteur.fr)
- There Is No Vaccine to Prevent or Treat HIV Infection. (trilinkbiotech.com)
- US-supported HIV.gov states that there is currently no vaccine available that will prevent HIV infection or treat those who have it. (trilinkbiotech.com)
- eveloping safe, effective, and affordable vaccines that can prevent HIV infection is the NIH's highest HIV research priority given its game-changing potential for controlling and ultimately ending the HIV/AIDS pandemic. (trilinkbiotech.com)
- If those experiments go well, he said, further studies will examine whether it can protect animals against infection, and human trials for safety and vaccine efficacy would be next - though it may be years before those results are known. (factbuckscounty.org)
- While designing a vaccine against any pathogen is a long, hard process, HIV has been particularly difficult, and despite decades of efforts and hundreds of millions of dollars spent in the process, we still do not yet have an effective vaccine that can prevent infection. (factbuckscounty.org)
- Findings from this AIDS research could boost the development of vaccines that will thwart infection by targeting and crippling the sticky HIV-1 spike proteins. (fsu.edu)
- Until now, despite intensive study by many laboratories, the design details of the spikes and their distribution pattern on the surface of the virus membrane have been poorly understood, which has limited our understanding of how the virus infection actually occurs and frustrated efforts to create vaccines,' Roux said. (fsu.edu)
- Around the world and here in the United States, HIV infection rates are on the rise again, especially in younger people," says Todd Wiggins, the founder of Action Cycling Atlanta and its first AIDS Vaccine ride in 2003. (projectq.us)
- Then the infection will progress to AIDS. (medlineplus.gov)
- However many had the misconception that "HIV/AIDS does not influence Iran" and "I will not be infected with HIV/AIDS under any conditions" and 63.6% agreed that lack of religious and moral commitment could spread AIDS infection. (who.int)
- Rhesus macaques receiving a priming vaccine followed by multiple booster inoculations had a 79% lower per-exposure risk of infection by simian-human immunodeficiency virus (SHIV) compared to unvaccinated animals. (nih.gov)
- The goal of the trial, designated HVTN 702 and known as Uhambo, was to test in South Africa the improved version of the Thai vaccine, which remains the only one ever shown to reduce HIV infection rates. (fredhutch.org)
- When you get a vaccine, it sparks your immune system to create immune responses that help your body fight off infection. (medlineplus.gov)
Programme1
- NaturalNews) Representing the seventh round of cases successfully treated since 2007, 68 people were recently discharged from Gambia's Presidential Alternative Medical Treatment Programme (PAMTP) after reportedly being cured of either HIV or AIDS. (vaccineliberationarmy.com)
Receive the vaccine4
- To register to receive the vaccine, visit www.phila.gov/vaccineinterest , or call the Health Department at (215) 685-5488. (whyy.org)
- Then there is phase 2, expanded trials, where hundreds of people receive the vaccine, in groups to see if there is a different response depending on the age group. (mymcmedia.org)
- Then the vaccine progresses to phase 3, efficacy trials, where thousands of people receive the vaccine, and researchers see how many become infected. (mymcmedia.org)
- Out of the 4,913 school-aged children eligible to receive the vaccine, only 317 are fully vaccinated. (chestercity.com)
Live attenuated7
- Many successful vaccines are based on live attenuated (weakened) versions of the parental virus. (fda.gov)
- Live, attenuated influenza vaccine (LAIV) is a nasal spray that can be given to non-pregnant people 2 through 49 years of age. (cdc.gov)
- Also known as live, attenuated influenza vaccine (LAIV), this nasal spray contains live viruses. (cdc.gov)
- FDA approved this live attenuated influenza virus (LAIV) nasal spray vaccine for persons 2 through 49 years of age. (cdc.gov)
- Conventional vaccines such as live attenuated and killed virus fail against the highly variable and evasive HIV. (chavd.org)
- Inactivated and trivalent oral poliovirus vaccines contain either formalin- inactivated or live, attenuated poliovirus, respectively, of the three serotypes. (who.int)
- Recommendations to assure the quality, safety and efficacy of live attenuated poliomyelitis vaccine (oral). (who.int)
Moderna2
- A leader from Praxis explains how the firm worked with Moderna on patient recruitment strategy and other solutions in the road to launching a vaccine. (outsourcing-pharma.com)
- [ 1 ] Two mRNA monoclonal vaccines (Comirnaty by Pfizer and Spikevax by Moderna) gained full approval by the US Food and Drug Administration (FDA). (medscape.com)
Pfizer-BioNTech1
- As it became apparent that the Pfizer-BioNTech vaccine stood the best chance of being the first vaccine to gain approval from the FDA and similar agencies around the world, the picture began to became clearer. (ups.com)
Drugs and Vaccines1
- In the future, this work may aid the development of much needed drugs and vaccines against RVFV. (st-andrews.ac.uk)
Polio vaccine2
- These organizations, collaborations, and researchers are attempting to better organize the human and technical resources needed to challenge this formidable foe on the scale of the Manhattan Project or the March of Dimes search for a polio vaccine. (cdc.gov)
- The final nail is in the coffin for the now largely refuted theory that the human immunodeficiency virus type 1 (HIV-1) crossed into humans as a result of contamination of oral polio vaccine (OPV), according to a new study. (the-scientist.com)
Global HIV Vaccine Enterprise2
- Global HIV Vaccine Enterprise, the Partnership for AIDS Vaccine Evaluation, and the Center for HIV-AIDS Vaccine Immunology). (cdc.gov)
- She is a member of the Advisory Group of the IAS Global HIV Vaccine Enterprise. (iasociety.org)
Antigens7
- We are using two proven strategies for increasing vaccine potency: the first is to present HIV antigens as part of a virus-like particle (VLP). (fda.gov)
- The experience with HIV vaccine antigens will provide CBER with the expertise it needs to evaluate proposed HIV vaccines and anticipate their likely side effects. (fda.gov)
- mRNA/modRNA vaccines represent attractive options because they can be relatively rapidly designed against various pathogen antigens and manufactured at scale. (trilinkbiotech.com)
- Pilot studies by a number of groups have demonstrated that plant viral expression systems can produce HIV antigens in quantities that are appropriate for use in vaccines. (edu.au)
- Vaccines or candidate vaccines containing inactivated HIV or some of its component antigens and designed to prevent or treat AIDS . (bvsalud.org)
- Some vaccines containing antigens are recombinantly produced. (bvsalud.org)
- Small synthetic peptides that mimic surface antigens of pathogens and are immunogenic, or vaccines manufactured with the aid of recombinant DNA techniques. (rush.edu)
Epidemic8
- Despite the enormous success of drug treatment, vaccines remain the best solution and likely a necessary component of any package that truly ends the AIDS epidemic. (lww.com)
- To stop the epidemic and related health inequities by eliminating new infections, maximizing healthier outcomes for those infected and at risk, and tackling the root causes of HIV/AIDS. (aac.org)
- There are multiple genetic variants of HIV-1 driving the epidemic in the region and too few vaccine candidates in the pipeline targeting those subtypes. (who.int)
- The epidemic is becoming more youth-driven," says Linda-Gail Bekker of the Desmond Tutu HIV Centre in Cape Town, who is preparing for AIDS vaccine trials involving adolescents in South Africa. (vaxreport.org)
- AIDS Czar Kristine Gebbie describes her efforts to control the epidemic and prevent future spread of the disease. (charlierose.com)
- Mary Fisher of the National Commission on AIDS describes her mission to communicate the urgency of the AIDS epidemic. (charlierose.com)
- There are no vaccines or treatments available for use in humans so if there is a serious outbreak of the virus it could become an epidemic and cause great economic loss and severe human disease. (st-andrews.ac.uk)
- A pioneering virologist who has led HIV/AIDS research on treatments and vaccines since the early days of the epidemic, Corey is also president and director emeritus of Fred Hutch. (fredhutch.org)
Rite Aid9
- Rite Aid said it still recommends scheduling an appointment, but it will now make a limited number of shots available for walk-in customers. (roi-nj.com)
- Rite Aid Chief Operating Officer Jim Peters said the announcement is another positive step. (roi-nj.com)
- If traveling to Hawaii, please note that Rite Aid and Bartell Drugs are not currently among the approved partners for testing before traveling to Hawaii. (nufo.org)
- On the day of your Test be sure to bring your government-issued ID Card like a license drive for the drive-through at your selected rite aid testing location, a Rite Aid pharmacist will greet you and confirm your appointment and identity they'll place a testing kit through the window of the drive-through then they'll walk you through the test. (nufo.org)
- Does Rite Aid doing anything to keep their customers safe? (nufo.org)
- During this unprecedented crisis, we have taken several additional precautions to continue to serve Rite Aid customers when they are most in need of Rite Aid help. (nufo.org)
- of the Rite Aid stores, pharmacies, and distribution centers comply with CDC guidelines to prevent the spread of the virus. (nufo.org)
- You are leaving the main Rite Aid website to visit our photo site. (riteaid.com)
- Rite Aid Rewards is not valid on photo purchases. (riteaid.com)
South Africa3
- In fact, some 60% of Power Africa financial aid goes to relatively wealthy Nigeria and South Africa, not the numerous really poor countries - and countries receiving funds for wind and solar are not getting money for gas-fired power. (wattsupwiththat.com)
- Dr. Larry Corey is principal investigator for the Hutch-based HIV Vaccine Trials Network, which carried out the study of the Uhambo vaccine in South Africa. (fredhutch.org)
- The deeply disappointing findings were sobering news for researchers at Seattle's Fred Hutchinson Cancer Research Center, which leads the HIV Vaccine Trials Network , or HVTN, which coordinated the trials with partners in South Africa. (fredhutch.org)
Immunogenicity2
- a key question for HIV-1 vaccine development is whether the immunogenicity of mRNA vaccines encoding HIV-1 immunogens, a poorly immunogenic protein that requires extensive post-translational modifications, is comparable to that of proteins that can be purified after in vitro production. (trilinkbiotech.com)
- Safety and immunogenicity of a polyvalent peptide C4-V3 HIV vaccine in conjunction with IL-12. (rush.edu)
Prevention11
- While some prevention successes have been attained (e.g., screening of the blood supply in industrialized countries), a safe and effective vaccine-the "holy grail" of public health prevention-remains elusive. (cdc.gov)
- The Economist examines how despite gains in HIV/AIDS treatment and prevention, years of research has brought "the field no nearer to what is really neededâ€"a vaccine that will stop people getting infected in the first place. (kff.org)
- As an HIV/AIDS researcher, he has been involved in the scientific effort since AIDS was recognized in 1981, conducting pivotal studies that underpin the current understanding of the disease and efforts to develop therapies and tools of prevention. (iasociety.org)
- Prevention is key to the strategy to fighting AIDS, but it's clearly not going to work with everybody everywhere, so research for an AIDS vaccine has to be a prominent part of the overall strategy," he continues. (projectq.us)
- Prevention and treatment, yes, but a vaccine is the only way we're ever going to see an end to this thing. (projectq.us)
- Refinement and development of existing and new prevention and treatment technologies--including safe, effective, and accessible AIDS vaccines--are urgent public health priorities. (who.int)
- Is there a role for plant-made vaccines in the prevention of HIV/AIDS? (edu.au)
- This study investigated the knowledge, attitudes and practices towards HIV/AIDS prevention of a random sample of prisoners in 5 prisons in Mazandaran province. (who.int)
- HIV/AIDS prevention efforts are needed for prisoners in Mazandaran province. (who.int)
- Reducing HIV incidence , as well as prevalence and AIDS -related mortality , in these high- risk fishing communities in Uganda is attainable over 15 years with a combination prevention package. (bvsalud.org)
- Since its inception in 1994, our studies have helped to shape national and global responses to the HIV/AIDS pandemic, and have defined policies and standards regarding the course of HIV acquisition, prevention, treatment, and care. (uz-ctrc.org)
Tuberculosis1
- Early in this century, researchers in France demonstrated that a weakened strain of the bacterium responsible for cow tuberculosis could provide some protection against human TB when administered as a vaccine. (mit.edu)
Efficacy trials1
- The large efficacy trials for the HPV vaccine involved thousands of adolescent (age 12-18) and pre-adolescent girls, and many researchers are closely monitoring the acceptance and inclusion of this new vaccine into immunization programs to help gauge the response to vaccines still in development that aim to prevent other sexually-transmitted infections, including HIV and herpes simplex virus type 2. (vaxreport.org)
Subunit vaccines1
- In my opinion killed virus and subunit vaccines are more appropriate for your cat's circumstances. (catster.com)
Iterative vaccine1
- Detailed analysis and understanding of immune responses in humans will be crucial to iterative vaccine design improvements. (chavd.org)
UNAIDS3
- According to the Joint UN Program on AIDS (UNAIDS), an estimated 4.9 million adults and children are living with HIV in Asia and the Pacific. (who.int)
- Our projected intervention coverage levels are well within the national targets set by the Uganda government and enable coming close to reaching the UNAIDS 95-95-95 targets to end AIDS as a public health threat by 2030. (bvsalud.org)
- Apresenta o Relatório sobre o Acesso Universal ao HIV/AIDS, publicado pela Organização Mundial da Saúde (OMS), o Fundo de Nações Unidas para a Infância (UNICEF) e o Programa Conjunto das Nações Unidas sobre o HIV/Aids (UNAIDS). (bvs.br)
Trials Network2
- In December, the clinic began enrolling about 120 local men in its portion of the HIV Vaccine Trials Network Lifeforward Study , which is testing a preventative vaccine on 1,350 men in 12 U.S. cities. (projectq.us)
- UZCHS-CTU's Seke South CRS has been officially selected as a protocol specific site by the US National Institutes of Health's HIV Vaccine Trials Network (HVTN). (uz-ctrc.org)
Immunisation1
- Alliance for Vaccines and Immunisation. (cdc.gov)
Dose6
- The vaccine contained no detectable AIDS virus-related sequences at a sensitivity of less than one picogram of DNA per 20-ug dose of vaccine. (cdc.gov)
- Following at least half a year of negotiations, the DAC seemed to agree on a price per vaccine of US$6.72 per dose. (eurodad.org)
- Firstly, so far the DAC has failed to put in place strong ODA-eligibility criteria for vaccine dose donations. (eurodad.org)
- They will also work closely with those same facilities to ensure a seamless second-dose process, and to provide vaccines to new residents and staff upon their arrival over the next several months. (whyy.org)
- Vaccine efficacy (VE) was shown to wane over time following an initial 2-dose primary series with the mRNA vaccines and the 1-dose regimen with the Janssen vaccine. (medscape.com)
- People aged ≥ 65 years who received 1 dose of a vaccine have the option to receive 1 additional dose at least 4 months after the first bivalent dose. (medscape.com)
Recombinant vaccines1
- Despite advances in recombinant DNA technology, only a handful of recombinant vaccines have been approved so far, and these are particle formers: hepatitis B surface antigen (HBsAg) assembles 22 nm particles with a strong lipid component. (fda.gov)
Immune system3
- Vaccines are designed to help the immune system organize and prepare for exposure to disease. (catster.com)
- Designing an effective HIV/AIDS vaccine is something of a paradox: a good vaccine would be safe and look enough like HIV to kick-start the immune system into neutralizing the virus - but the problem is that this is exactly what the human immune system has trouble doing even when it's exposed to the real thing. (factbuckscounty.org)
- The details of the vaccine regimen differed among subgroups of vaccinated animals but involved priming the immune system with a vaccine modified to optimize antibody creation. (nih.gov)
Researchers8
- The number of HIV vaccine researchers is now increasing, given the support of several organizations (e.g. (cdc.gov)
- The U.S. Food and Drug Administration granted approval for researchers at the University of Western Ontario to test the vaccine, which is based on a genetically modified killed whole virus. (winnipegfreepress.com)
- To make the vaccine, the researchers start by altering the genetic makeup of the human immunodeficiency virus to make it non-pathogenic - incapable of causing disease - then further inactivate it with chemicals and radiation. (winnipegfreepress.com)
- The new work also provides a method for researchers to assess whether other new vaccine proteins can bind their intended precursor B cells. (infectioncontroltoday.com)
- But before AIDS vaccine trials with promising candidates can be initiated in adolescents, researchers must tackle potentially thorny legal, ethical, and regulatory issues, and make sure they adequately address the concerns of parents about their children participating in research. (vaxreport.org)
- Statistics like these are helping to fuel discussions amongst researchers, sponsoring organizations, and regulatory agencies about how and when to test AIDS vaccine candidates in younger volunteers. (vaxreport.org)
- It's an excellent model for AIDS vaccine researchers," says Jeffrey Safrit of the Elizabeth Glaser Pediatric AIDS Foundation. (vaxreport.org)
- The vaccine was able to be made quickly because researchers already constructed an mRNA platform for cancer and other vaccines under trial. (swfinstitute.org)
Viral6
- The challenge for vaccine developers is to determine if an immunogen can present a particular viral surface in a way that distinct B cells can be activated, proliferate and be useful," said study co-author Shane Crotty, professor at the La Jolla Institute. (infectioncontroltoday.com)
- If proven, the preventative vaccine could slow the progression of HIV by decreasing the viral load of people already infected. (projectq.us)
- Agência fundada em 1992, sediada em Paris, que desenvolve pesquisas relacionadas à Aids e à hepatite viral B e C. Disponibiliza acesso a publicações e relatórios, informações sobre saúde púb. (bvsalud.org)
- patients with viral loads greater than 30,000/mL are 18.5 times more likely to die of AIDS than those with undetectable viral loads. (medscape.com)
- New combination vaccines should induce similar or superior levels of neutralizing antibody in serum for individual protection against paralytic disease and mucosal immunity that effectively decreases viral replication in the intestine and pharynx for population protection against transmission of poliovirus. (who.int)
- Two other monoclonal vaccines, a viral vector vaccine (Janssen) and an adjuvanted protein subunit vaccine (Novavax), were granted emergency use approval (EUA) in the United States. (medscape.com)
Development14
- We worked with Pfizer and 8 of the 10 vaccines in development," said Kate. (ups.com)
- In contrast, development of HIV-1 vaccines has been extremely difficult. (lww.com)
- This ongoing process of vaccine development and refinement relies on #animalresearch and as such can be labelled #MPAR. (speakingofresearch.com)
- These vaccines were never purchased for development purposes and both Eurodad and our partners have been saying for months that they should not not be counted as such. (eurodad.org)
- IMSEAR at SEARO: Expanding research capacity and accelerating AIDS vaccine development in Asia. (who.int)
- The Asian region faces several challenges for AIDS vaccine development. (who.int)
- In a document issued in May 2006 ( Development of Preventive HIV Vaccines for Use in Pediatric Populations ) the agency provided vaccine trial sponsors with direction on the requirements for licensure in adolescent populations. (vaxreport.org)
- co-chaired by Susan Buchbinder, US, and Georgia Tomaras, US, experts discussed the similarities and differences between HIV and SARS-CoV-2 mRNA vaccine development and how the renewed interest in exploiting the technology for the former-owing to its success in combatting. (univadis.com)
- Novavax has also been selected to participate in Operation Warp Speed and has been awarded $1.6 billion to aid in vaccine development. (mymcmedia.org)
- Our overall mission is to define immunogens and immunization regimens that can guide product development strategies for a preventive human AIDS vaccine. (chavd.org)
- Learn more about the Scripps Consortium for HIV/AIDS Vaccine Development and our scientific advances. (chavd.org)
- However, the Novavax vaccine leverages the older vaccine development techniques , where the injection introduces the protein and not the genetic recipe. (legalreader.com)
- The HVTN's mission is to facilitate the process of testing preventative vaccines against HIV/AIDS and is a global leader in vaccine development. (uz-ctrc.org)
- WHO would also like to thank the Government of Ireland (Irish Aid), the United States Agency for International Development (USAID), and the Office of Foreign Disaster Assistance (OFDA) of USAID for their continued support in the development of these documents. (who.int)
Antibody3
- A research team has now found that the right precursor ("germline") cells for one kind of HIV broadly neutralizing antibody are present in most people, and has described the design of an HIV vaccine germline-targeting immunogen capable of binding those B cells. (infectioncontroltoday.com)
- Too much inflammation and Antibody production causes AIDS. (healthyindianow.in)
- Their results, published in Nature Medicine , show that the novel vaccine was safe and prompted desired antibody and cellular immune responses against an HIV-like virus. (nih.gov)
Pandemic5
- Dr Fauci has been a key advisor to six U.S. Presidents and their administrations on global AIDS issues and initiatives to bolster medical and public health preparedness against emerging infectious disease threats, such as pandemic influenza. (iasociety.org)
- Clawing back any unspent funds from the trillions that Washington flooded the economy with during the pandemic is an obvious starting place for any debt ceiling discussion," said Tim Reitz, executive director of the House Freedom Caucus, one of several Republican groups that has said the remaining aid should be canceled. (medscape.com)
- Progress in these areas will help guarantee that an effective AIDS vaccine, when available, will reach both adult and adolescent populations as quickly as possible, offering the greatest chance for curbing the pandemic. (vaxreport.org)
- Although educational programs have had some impact, immunization against HIV will be necessary to control the AIDS pandemic. (edu.au)
- An HIV vaccine is essential to end the global pandemic, and we hoped this vaccine candidate would work. (fredhutch.org)
Preventive1
- Ethical considerations in HIV preventive vaccine research. (who.int)
Uptake1
- Hence, it is necessary to develop targeted strategies to boost vaccine uptake among this vulnerable population. (bvsalud.org)
Operation Warp Speed2
- We have spent months strategising with Operation Warp Speed officials and our healthcare customers about efficient vaccine logistics, and the time has come to put the plan into action. (ups.com)
- We are honored to partner with Operation Warp Speed to move our vaccine candidate forward with extraordinary urgency in the quest to provide vital protection to our nation's population," said Stanley C. Erck, President and Chief Executive Officer of Novavax. (mymcmedia.org)
Genetic3
- The Whitehead scientists will also begin to hone in on the ideal genetic make-up of an improved TB vaccine for human beings. (mit.edu)
- The vaccine works by delivering genetic instructions to the body, which results in the formation of two types of proteins characteristic of the virus. (vaughantoday.ca)
- These vaccines inject the genetic recipe into the body cells, and those cells, in turn, produce the protein so that our immunity can fight the disease. (legalreader.com)
Hepatitis5
- Recent studies have provided important additional assurances concerning the safety of hepatitis B (HB) vaccine. (cdc.gov)
- The vaccine currently licensed in the United States is produced from pooled plasma of hepatitis B surface antigen-positive individuals, some of whom are also in high-risk groups for acquired immunodeficiency syndrome (AIDS). (cdc.gov)
- A vaccine against hepatitis B virus (HBV) was the only one to target this age group until a vaccine for human papillomavirus (HPV) was recently licensed by the FDA for girls aged 9 to 26 (see February 2006 Spotlight article, Cervical cancer vaccines ). (vaxreport.org)
- Other vaccines that combine DTP and/or Haemophilus influenzae type b and/or hepatitis B with IPV appear feasible but require further investigation. (who.int)
- Other vaccines that use the same model as Novavax include diphtheria toxoid vaccines, tetanus toxoid vaccines, the hepatitis B virus, and others. (legalreader.com)
Human papillomavirus1
- Attitudes about human papillomavirus vaccine in young women. (bvsalud.org)
Proteins2
- The Env proteins produced in the mice from the mRNA instructions closely resembled those in the whole virus, an improvement over previous experimental HIV vaccines. (nih.gov)
- So, the main difference is that this vaccine uses proteins made outside the body and injects them into the system to aid immunity. (legalreader.com)
Immunogens1
- These include at least the HIV-1-derived immunogens, their delivery, vaccine formulation and immunomodulation [11▪,12,13] . (lww.com)
Protein5
- The vaccine elicited a strong T cell response to SIV Gag protein. (fda.gov)
- It is remarkable that protein design can be so specific as to 'find' one in a million cells, demonstrating the feasibility of this new vaccine strategy. (infectioncontroltoday.com)
- As the world marks the 25th year since the first diagnosed case of AIDS, groundbreaking research by scientists at Florida State University has produced remarkable three-dimensional images of the virus and the protein spikes on its surface that allow it to bind and fuse with human immune cells. (fsu.edu)
- Traditional vaccines revolved around injecting part of the pathogen, such as a protein or sugar, to induce an immune response. (swfinstitute.org)
- It is unclear what change this new vaccine can bring about, but the makers promote it as a traditional protein-style vaccine. (legalreader.com)
Hesitancy1
- Yet, Syrian refugees in the country report highest numbers of hesitancy in taking the vaccine shots - 71% according to our latest findings. (wvi.org)
Remains an elusive goal2
- Despite nearly four decades of efforts by the global scientific community, finding an effective HIV vaccine remains an elusive goal," immunologist Anthony Fauci, co-author of the study and a House of Representatives adviser, said in a statement. (vaughantoday.ca)
- Despite nearly four decades of effort by the global research community, an effective vaccine to prevent HIV remains an elusive goal," said NIAID Director Anthony S. Fauci, M.D., chief of the Laboratory and a paper co-author. (nih.gov)
Globally2
- Since that study, millions of people have died from HIV/AIDS globally. (5newsonline.com)
- Hopefully implementation data from UK will soon increase confidence in what I hope will still be an important globally accessible vaccine. (rt.com)
Candidates1
- In fact, said principal investigator and FSU Professor Kenneth H. Roux, at least two laboratories already are crafting vaccine candidates based on preliminary results uncovered by his team of structural biologists. (fsu.edu)
Adjuvant2
- This vaccine also contains immune stimulants like adjuvant. (legalreader.com)
- In addition, the vaccine used a different adjuvant, an ingredient designed to stir the immune response. (fredhutch.org)
Scientists5
- Our laboratory is working to solve some of the difficult problems facing scientists who are trying to develop a safe and effective vaccine against HIV, the virus that causes AIDS. (fda.gov)
- Thus scientists need to stay vigilant and to regularly obtain scientific information on how vaccines could be updated to help the body to fight off viruses. (speakingofresearch.com)
- By understanding how the vaccine works and how it can be modified to be more effective against SIV in monkeys, the scientists obtained evidence suggesting it is likely to be highly effective with HIV, also establishing the scientific bridge to humans along the way by modifying the vaccine in ways needed to be effective against HIV. (speakingofresearch.com)
- Making an HIV vaccine is a difficult and complex task that has eluded scientists for more than 35 years. (chavd.org)
- It works like a giant microscope, harnessing the power of electrons to produce bright light that scientists can use to study anything from fossils to jet engines to viruses and vaccines. (st-andrews.ac.uk)
Safe10
- BCG vaccines have a long record of safe use, but their reported efficacy varies tremendously," said Dr. Murray, the Whitehead postdoctoral fellow who is first author of the PNAS paper. (mit.edu)
- That is, is the vaccine safe, and is it effective? (kuer.org)
- Vaccine availability is improving every day, and our pharmacists are ready to administer vaccines safely and efficiently, providing the benefits of pharmacist-administered vaccines in a safe and sterile environment right in your neighborhood. (roi-nj.com)
- Wealthy nations also would provide funding to pharmaceutical companies when they produce safe and effective vaccines, and drug makers would sell the vaccines at reduced prices in developing countries when G8 nations have provided the promised amount. (khn.org)
- Everybody should go with that vaccine as long as it's safe and effective. (rt.com)
- There are safe vaccines that can help reduce the risk from flu and its potentially serious complications. (cdc.gov)
- As the New York Times outlines, there are specific phases a vaccine needs to go through in order to be deemed safe for the public. (mymcmedia.org)
- DSMBs periodically monitor such large-scale trials to see if the vaccine is safe and effective. (fredhutch.org)
- On January 23, they found that while the vaccine was perfectly safe, it was not working. (fredhutch.org)
- Research continues on other approaches to a safe and effective HIV vaccine, which I still believe can be achieved. (fredhutch.org)
Approaches2
- Epidemiologic approaches to detect an association between HB vaccine and AIDS have included analysis of data on AIDS cases reported to CDC concerning their receipt of HB vaccine and monitoring rates of AIDS in groups of homosexually active men who did or did not receive HB vaccine in the vaccine trials conducted by CDC in Denver, Colorado, and San Francisco, California. (cdc.gov)
- Vaccine approaches against AIDS have focused on inducing cellular immune responses, since many studies revealed the role of T cell responses in the control of human immunodeficiency virus or simian immunodeficiency virus (SIV) infections. (pasteur.fr)