AIDS Dementia Complex
A neurologic condition associated with the ACQUIRED IMMUNODEFICIENCY SYNDROME and characterized by impaired concentration and memory, slowness of hand movements, ATAXIA, incontinence, apathy, and gait difficulties associated with HIV-1 viral infection of the central nervous system. Pathologic examination of the brain reveals white matter rarefaction, perivascular infiltrates of lymphocytes, foamy macrophages, and multinucleated giant cells. (From Adams et al., Principles of Neurology, 6th ed, pp760-1; N Engl J Med, 1995 Apr 6;332(14):934-40)
N-(N-(N(2)-(N-(N-(N-(N-D-Alanyl L-seryl)-L-threonyl)-L-threonyl) L-threonyl)-L-asparaginyl)-L-tyrosyl) L-threonine. Octapeptide sharing sequence homology with HIV envelope protein gp120. It is potentially useful as antiviral agent in AIDS therapy. The core pentapeptide sequence, TTNYT, consisting of amino acids 4-8 in peptide T, is the HIV envelope sequence required for attachment to the CD4 receptor.
An acquired organic mental disorder with loss of intellectual abilities of sufficient severity to interfere with social or occupational functioning. The dysfunction is multifaceted and involves memory, behavior, personality, judgment, attention, spatial relations, language, abstract thought, and other executive functions. The intellectual decline is usually progressive, and initially spares the level of consciousness.
Acquired Immunodeficiency Syndrome
An acquired defect of cellular immunity associated with infection by the human immunodeficiency virus (HIV), a CD4-positive T-lymphocyte count under 200 cells/microliter or less than 14% of total lymphocytes, and increased susceptibility to opportunistic infections and malignant neoplasms. Clinical manifestations also include emaciation (wasting) and dementia. These elements reflect criteria for AIDS as defined by the CDC in 1993.
A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA during reverse transcription. It improves immunologic function, partially reverses the HIV-induced neurological dysfunction, and improves certain other clinical abnormalities associated with AIDS. Its principal toxic effect is dose-dependent suppression of bone marrow, resulting in anemia and leukopenia.
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
HIV Envelope Protein gp120
External envelope protein of the human immunodeficiency virus which is encoded by the HIV env gene. It has a molecular weight of 120 kDa and contains numerous glycosylation sites. Gp120 binds to cells expressing CD4 cell-surface antigens, most notably T4-lymphocytes and monocytes/macrophages. Gp120 has been shown to interfere with the normal function of CD4 and is at least partly responsible for the cytopathic effect of HIV.
HIV Core Protein p24
A major core protein of the human immunodeficiency virus encoded by the HIV gag gene. HIV-seropositive individuals mount a significant immune response to p24 and thus detection of antibodies to p24 is one basis for determining HIV infection by ELISA and Western blot assays. The protein is also being investigated as a potential HIV immunogen in vaccines.
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Dictionaries as Topic
Diseases of multiple peripheral nerves simultaneously. Polyneuropathies usually are characterized by symmetrical, bilateral distal motor and sensory impairment with a graded increase in severity distally. The pathological processes affecting peripheral nerves include degeneration of the axon, myelin or both. The various forms of polyneuropathy are categorized by the type of nerve affected (e.g., sensory, motor, or autonomic), by the distribution of nerve injury (e.g., distal vs. proximal), by nerve component primarily affected (e.g., demyelinating vs. axonal), by etiology, or by pattern of inheritance.
Peripheral, autonomic, and cranial nerve disorders that are associated with DIABETES MELLITUS. These conditions usually result from diabetic microvascular injury involving small blood vessels that supply nerves (VASA NERVORUM). Relatively common conditions which may be associated with diabetic neuropathy include third nerve palsy (see OCULOMOTOR NERVE DISEASES); MONONEUROPATHY; mononeuropathy multiplex; diabetic amyotrophy; a painful POLYNEUROPATHY; autonomic neuropathy; and thoracoabdominal neuropathy. (From Adams et al., Principles of Neurology, 6th ed, p1325)
A group of genetic, infectious, or sporadic degenerative human and animal nervous system disorders associated with abnormal PRIONS. These diseases are characterized by conversion of the normal prion protein to an abnormal configuration via a post-translational process. In humans, these conditions generally feature DEMENTIA; ATAXIA; and a fatal outcome. Pathologic features include a spongiform encephalopathy without evidence of inflammation. The older literature occasionally refers to these as unconventional SLOW VIRUS DISEASES. (From Proc Natl Acad Sci USA 1998 Nov 10;95(23):13363-83)
A prion disease found exclusively among the Fore linguistic group natives of the highlands of NEW GUINEA. The illness is primarily restricted to adult females and children of both sexes. It is marked by the subacute onset of tremor and ataxia followed by motor weakness and incontinence. Death occurs within 3-6 months of disease onset. The condition is associated with ritual cannibalism, and has become rare since this practice has been discontinued. Pathologic features include a noninflammatory loss of neurons that is most prominent in the cerebellum, glial proliferation, and amyloid plaques. (From Adams et al., Principles of Neurology, 6th ed, p773)
A rare transmissible encephalopathy most prevalent between the ages of 50 and 70 years. Affected individuals may present with sleep disturbances, personality changes, ATAXIA; APHASIA, visual loss, weakness, muscle atrophy, MYOCLONUS, progressive dementia, and death within one year of disease onset. A familial form exhibiting autosomal dominant inheritance and a new variant CJD (potentially associated with ENCEPHALOPATHY, BOVINE SPONGIFORM) have been described. Pathological features include prominent cerebellar and cerebral cortical spongiform degeneration and the presence of PRIONS. (From N Engl J Med, 1998 Dec 31;339(27))
Small proteinaceous infectious particles which resist inactivation by procedures that modify NUCLEIC ACIDS and contain an abnormal isoform of a cellular protein which is a major and necessary component. The abnormal (scrapie) isoform is PrPSc (PRPSC PROTEINS) and the cellular isoform PrPC (PRPC PROTEINS). The primary amino acid sequence of the two isoforms is identical. Human diseases caused by prions include CREUTZFELDT-JAKOB SYNDROME; GERSTMANN-STRAUSSLER SYNDROME; and INSOMNIA, FATAL FAMILIAL.
A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
Encyclopedias as Topic
Cerebral vasculopathy in HIV infection revealed by transcranial Doppler: A pilot study. (1/587)BACKGROUND AND PURPOSE: There is growing evidence for affection of cerebral vessels during human immunodeficiency virus (HIV) infection. We prospectively evaluated cerebrovascular reserve capacity (CRC) in HIV-seropositive patients by transcranial Doppler sonography (TCD) after systemic administration of acetazolamide. We hypothesized that a disturbed vasoreactivity would reflect the cerebral arteries' involvement in HIV infection. METHODS: We assessed the mean blood flow velocity (BFV) of the middle cerebral artery and its increase after intravenous administration of 1 g acetazolamide (CRC) in 31 HIV-infected individuals without symptoms of cerebrovascular disease (mean+/-SD age, 39+/-11 years). Stenotic or occlusive lesions of the large brain-supplying arteries were excluded by color-coded duplex and transcranial imaging. BFV and CRC were also measured in an age-matched group of 10 healthy control subjects. Patients were classified according to clinical, laboratory, and neurophysiological parameters. We also performed cerebral MRI (n=25) and rheumatological blood tests (n=26). RESULTS: Baseline BFV and CRC both were significantly reduced in HIV-infected patients as compared with control subjects (P<0.05, Student's t test). These findings did not correlate with duration of seropositivity, helper cell count, or other clinical, rheumatological, and neuroradiological findings. CONCLUSIONS: Our findings support the hypothesis of a cerebral vasculopathy etiologically associated with HIV infection. (+info)
Proton magnetic resonance spectroscopy pattern of progressive multifocal leukoencephalopathy in AIDS. (2/587)The objective was to determine whether the use of intermediate echo times (135 ms) in proton magnetic resonance spectroscopy (1H-MRS) detects a homogenous pattern in progressive multifocal leukoencephalopathy (PML) in HIV-1 infected people, and to confirm the results of previous studies. Six patients infected with HIV-1, with PML established by biopsy, and six healthy age and sex matched volunteers were evaluated to define their spectroscopic pattern. 1H-MRS spectra performed at 1.5 T were obtained with the STEAM sequence: TE/TM/TR, 20 ms/13.7 ms/2000 ms; 2500 Hz, size 2048 points, 256 acquisitions (STEAM-20) and with the PRESS sequence; TE/TR, 135 ms/2000 ms; 2500 Hz, size 2048 points, 256 acquisitions (PRESS-135). A single voxel was placed on the lesions and on the parieto-occipital white matter of controls. The peaks of N-acetylaspartate (NAA), choline (Cho), myoinositol (mI), lactate, and lipids were considered, and the results were expressed using creatine as reference. Spectra of PML lesions were characterised by significantly reduced NAA, lactate presence, and by significantly increased Cho and lipids compared with control group values. These results indicate that 1H-MRS detects a homogenous pattern in PML lesions. Recent studies, together with this, suggest that 1H-MRS may help in the diagnostic approach to patients with suspected PML lesions associated with AIDS. (+info)
Increased peroxynitrite activity in AIDS dementia complex: implications for the neuropathogenesis of HIV-1 infection. (3/587)Oxidative stress is suggested to be involved in several neurodegenerative diseases. One mechanism of oxidative damage is mediated by peroxynitrite, a neurotoxic reaction product of superoxide anion and nitric oxide. Expression of two cytokines and two key enzymes that are indicative of the presence of reactive oxygen intermediates and peroxynitrite was investigated in brain tissue of AIDS patients with and without AIDS dementia complex and HIV-seronegative controls. RNA expression of IL-1beta, IL-10, inducible nitric oxide synthase, and superoxide dismutase (SOD) was found to be significantly higher in demented compared with nondemented patients. Immunohistochemical analysis showed that SOD was expressed in CD68-positive microglial cells while inducible nitric oxide synthase was detected in glial fibrillary acidic protein (GFAP)-positive astrocytes and in equal amounts in microglial cells. Approximately 70% of the HIV p24-Ag-positive macrophages did express SOD, suggesting a direct HIV-induced intracellular event. HIV-1 infection of macrophages resulted in both increased superoxide anion production and elevated SOD mRNA levels, compared with uninfected macrophages. Finally, we show that nitrotyrosine, the footprint of peroxynitrite, was found more intense and frequent in brain sections of demented patients compared with nondemented patients. These results indicate that, as a result of simultaneous production of superoxide anion and nitric oxide, peroxynitrite may contribute to the neuropathogenesis of HIV-1 infection. (+info)
Rate and severity of HIV-associated dementia (HAD): correlations with Gp41 and iNOS. (4/587)BACKGROUND: Fifteen to thirty percent of AIDS patients develop some type of neurologic disorder during the course of their illness and the vast majority of these neurologic disorders will be HIV-associated dementia (HAD). These patients can exhibit varying degrees of severity and rates of progression of HAD. Neuropathologic variables that are associated with the rate of progression of HAD are not known. MATERIALS AND METHODS: Tissue was collected at autopsy from the Johns Hopkins University HIV Neurology Program. Seventy-one AIDS patients of this prospectively characterized population were followed until death to obtain information on dementia severity and the rate of neurological progression. Immunoblot analysis of immunological nitric oxide synthase (iNOS), HAM56, gp41, p24, gp120, and beta-tubulin was performed and the levels of iNOS, HAM56, gp41, and p24 were normalized to beta-tubulin and analyzed for significance by means of the Kruskal-Wallis test for multiple groups. RESULTS: We have identified unique groups within this spectrum and designated them slow, moderate, and rapid progressors. Slow and moderate progressors' neurological progression occurs over a course of months to years, whereas the rapid progressors' disease shows rapid increases in severity over weeks to months. In the present study we demonstrate that the severity and rate of progression of HAD correlates significantly with levels of the HIV-1 coat protein, gp41, iNOS, and HAM56, a marker of microglial/macrophage activation. CONCLUSION: The severity and rate of progression of HAD correlates with indices of immune activation as well as levels of iNOS and gp41. There appears to be a threshold effect in which high levels of gp41, iNOS, and immune activation are particularly associated with severe (Memorial Sloan-Kettering score 3 to 4) and rapidly progressive HAD. (+info)
The SIV-infected rhesus monkey model for HIV-associated dementia and implications for neurological diseases. (5/587)The neuropathogenesis of human immunodeficiency virus (HIV)-associated dementia has remained elusive, despite identification of HIV as the causal agent. Although a number of contributing factors have been identified, the series of events that culminate in motor and cognitive impairments after HIV infection of the central nervous system (CNS) are still not known. Rhesus monkeys infected with simian immunodeficiency virus (SIV) manifest immunosuppression and CNS disease that is pathologically [L. R. Sharer et al. (1991) J. Med. Primatol. 20, 211-217] and behaviorally [E. A. Murray et al. (1992) Science 255, 1246-1249] similar to humans. The SIV model of HIV-associated dementia (HAD) is widely recognized as a highly relevant model in which to investigate neuropathogenesis. With better understanding of neuropathogenesis comes the opportunity to interrupt progression and to design better treatments for HAD. This becomes increasingly important as patients live longer yet still harbor HIV-infected cells in the CNS. The use of the SIV model has allowed the identification of neurochemical markers of neuropathogenesis important not only for HAD, but also for other inflammatory neurological diseases. (+info)
Do alcohol and cocaine abuse alter the course of HIV-associated dementia complex? (6/587)Although psychoactive drugs are commonly used by AIDS patients, it is unclear whether commonly abused drugs, such as cocaine and ethanol, affect the course of HIV-associated dementia (HADC). Epidemiological studies have resulted in conflicting conclusions as to what role, if any, abused drugs play in HADC. In this review we discuss the clinical and pathological evidence that cocaine and ethanol might exacerbate the detrimental effects of HIV infection on the brain. We also review studies of cocaine and ethanol effects on various components of the immune system both in the presence and absence of retroviral infection. Data from these studies indicate that cocaine and ethanol have profound effects on the immune system that, in many respects, are enhanced by retroviral infection. We conclude that abused drugs likely affect the course of HADC but that proof awaits an examination of their interactive effects in an appropriate in vivo system of retroviral encephalitis. (+info)
Angiographic abnormalities in progressive multifocal leukoencephalopathy: an explanation based on neuropathologic findings. (7/587)BACKGROUND AND PURPOSE: Progressive multifocal leukoencephalopathy (PML) is typically occult at angiography and fails to enhance on MR images. After observing angiographic abnormalities characterized by arteriovenous shunting and pathologic parenchymal blush in patients with AIDS-related PML, often in the absence of contrast enhancement on MR images, we hypothesized that there might be distinct changes in the cerebral microvasculature that account for the reduction in vascular transit time (arteriovenous shunting) in the absence of blood-brain barrier dysfunction. METHODS: The imaging studies and neuropathologic specimens of six patients with biopsy-proved PML were reviewed retrospectively. In all patients contrast-enhanced MR imaging and CT, followed by cerebral angiography, were performed before stereotactically directed biopsy. The angiograms were evaluated for the presence of vascular displacement, pathologic parenchymal blush, arteriovenous shunting, and neovascularity. The CT and MR studies were reviewed for the presence of enhancement of the PML lesions. Biopsy specimens were examined for the presence of necrosis, perivascular inflammation, and neovascularity. RESULTS: All patients had oligodendrocytic intranuclear inclusions diagnostic of PML, together with perivascular inflammation and neovascularity to a varying extent; no other neuropathologic processes were identified. Angiographic abnormalities, characterized by a pathologic parenchymal blush and arteriovenous shunting, were identified in four of the six patients. In only one of these cases, however, was abnormal enhancement identified on cross-sectional imaging studies (MR and CT), and this patient had florid perivascular inflammatory infiltrates histologically. CONCLUSION: The pathologic parenchymal blush and arteriovenous shunting seen angiographically in some patients with PML reflect small-vessel proliferation and perivascular inflammatory changes incited by the presence of the JC virus in infected oligodendrocytes. (+info)
Bipolar disorder in old age. (8/587)OBJECTIVE: To review the classification, clinical characteristics, and epidemiology of bipolar disorders in old age with a special focus on neurologic comorbidity, high mortality, and management. QUALITY OF EVIDENCE: Most available data is gleaned from retrospective chart reviews and cohort studies. Treatment recommendations are based on evidence from younger populations and a few anecdotal case reports and series involving elderly people. MAIN MESSAGE: While relatively rare in the community setting, mania in old age frequently leads to hospitalization. It is associated with late-onset neurologic disorders (especially cerebrovascular disease) involving the right hemisphere and orbitofrontal cortex. Prognosis is relatively poor; morbidity and mortality rates are high. Management of bipolarity includes cautious use of mood stabilizers, especially lithium and divalproex. CONCLUSIONS: Mania in old age should trigger a careful assessment of underlying neurologic disease, especially cerebrovascular disease. Close clinical follow up is essential. (+info)
What does aids dementia complex mean?
Definition of aids dementia complex in the Definitions.net dictionary. Meaning of aids dementia complex. What does aids dementia complex mean? Information and translations of aids dementia complex in the most comprehensive dictionary definitions resource on the web.
HIV infection of macrophages and pathogenesis of AIDS dementia complex: Interaction of the host cell and viral genotype<...
TY - JOUR. T1 - HIV infection of macrophages and pathogenesis of AIDS dementia complex. T2 - Interaction of the host cell and viral genotype. AU - Cunningham, A. L.. AU - Naif, H.. AU - Saksena, N.. AU - Lynch, G.. AU - Chang, J.. AU - Li, S.. AU - Jozwiak, R.. AU - Alali, M.. AU - Wang, B.. AU - Fear, W.. AU - Sloane, A.. AU - Pemberton, L.. AU - Brew, B.. PY - 1997/7. Y1 - 1997/7. N2 - AIDS dementia complex (ADC) develops in only a third of HIV-infected patients who progress to AIDS. Macrophages and microglial cells are the major cellular sites of productive HIV replication in brain. Using 11 blood isolates of HIV from asymptomatic patients there was marked variation in tropism and the level of productive infection in recently adherent monocytes and monocyte-derived macrophages cultured in vitro. However, less variation was seen with 19 blood isolates from advanced HIV infection and 11 postmortem tissue isolates from brain, cerebrospinal fluid, spleen, and lung. Newly adherent monocytes ...
Effect of HIV-1 Tat on Secretion of TNF-α and IL-1β by U87 Cells in AIDS Patients with or without AIDS Dementia Complex<...
TY - JOUR. T1 - Effect of HIV-1 Tat on Secretion of TNF-α and IL-1β by U87 Cells in AIDS Patients with or without AIDS Dementia Complex. AU - Zhao, Li. AU - Pu, Shuang Shuang. AU - Gao, Wen Hua. AU - Chi, Yuan Yuan. AU - Wen, Hong Ling. AU - Wang, Zhi Yu. AU - Song, Yan Yan. AU - Yu, Xue Jie. PY - 2014/2. Y1 - 2014/2. N2 - Objective To explore the role of HIV-1 tat gene variations in AIDS dementia complex (ADC) pathogenesis. Methods HIV-1 tat genes derived from peripheral spleen and central basal ganglia of an AIDS patient with ADC and an AIDS patient without ADC were cloned for sequence analysis. HIV-1 tat gene sequence alignment was performed by using CLUSTAL W and the phylogentic analysis was conducted by using Neighbor-joining with MEGA4 software. All tat genes were used to construct recombinant retroviral expressing vector MSCV-IRES-GFP/tat. The MSCV-IRES-GFP/tat was cotransfected into 293T cells with pCMV-VSV-G and pUMVC vectors to assemble the recombinant retrovirus. After infection of ...
A Multicenter Placebo-Controlled Double-Blind Trial to Evaluate Azidothymidine (AZT) Treatment of the AIDS Dementia Complex and...
HIV infection can result in impairment in the function of the brain and spinal cord, leading to disturbances in the ability to think clearly and in strength and coordination. This disorder, which has been called the AIDS dementia complex, may be due to a direct effect of HIV on the nervous system. It is known that AZT does get into the brain to some extent, where it may reduce growth of HIV. It is hoped that AZT will stabilize or improve the symptoms of the AIDS dementia complex.. The study is done in 2 stages. In Stage 1, patients are randomized to receive placebo or 1 of 2 doses of AZT. Stage 1 lasts for 4 months. In Stage 2, patients who were initially treated with placebo are randomized again and all patients receive AZT. Stage 2 lasts an additional 12 months, during which time there are periodic medical and neurologic evaluations. Before beginning treatment, all patients have a lumbar puncture and a computerized tomographic (CT) scan of the brain. The lumbar puncture is repeated twice ...
OBJECTIVE--To assess the incidence of the AIDS dementia complex and the presence of HIV I p24 antigen in cerebrospinal fluid in relation to zidovudine treatment. DESIGN--Retrospective study of a consecutive series of patients with AIDS from 1982 to 1988. SETTING--An academic centre for AIDS. PATIENTS--196 Patients with AIDS and neurological symptoms examined from 1982 to 1988. INTERVENTIONS--Zidovudine treatment, which was introduced to The Netherlands on 1 May 1987 for patients with severe symptoms of HIV infection (Centers for Disease Control groups IVA, B, C, and D). MAIN OUTCOME MEASURES--Diagnosis of AIDS dementia complex and presence of HIV I p24 antigen in cerebrospinal fluid. RESULTS--The AIDS dementia complex was diagnosed in 40 of the 196 (20%) patients with AIDS. Thirty eight of 107 patients with AIDS (36%) not taking zidovudine developed the AIDS dementia complex compared with two of the 89 (2%) taking the drug (p less than 0.00001). The incidence of the AIDS dementia complex ...
AIDS Dementia Complex (ADC) - POZ
AIDS dementia complex (ADC), sometimes called HIV-associated dementia (HAD), is different than other types of AIDS-related illnesses.
Search of: HIV/AIDS AND neuroAIDS OR HIV/AIDS neuropathy OR polyneuropathy OR AIDS dementia complex OR AIDS neuropathy OR HIV...
23 Studies found for: HIV/AIDS AND neuroAIDS OR HIV/AIDS neuropathy OR polyneuropathy OR AIDS dementia complex OR AIDS neuropathy OR HIV neuropathy OR HIV-1 cognitive and motor complex OR AIDS-related primary CNS lymphoma , Recruiting, Not yet recruiting, Available Studies , NIH ...
DMOZ - Health: Conditions and Diseases: Neurological Disorders: Dementia: AIDS Dementia Complex
The AIDS dementia complex is a brain disorder that occurs in people with AIDS (HIV infection) that causes the loss of cognitive capacity, affecting the ability to function in a social or occupational setting.
Clinical Trial on AIDS Dementia Complex: Stavudine
The purpose of this study is to see if adding stavudine (d4T) to anti-HIV drug regimens (with or without zidovudine, ZDV) can improve symptoms of AIDS Dementia Complex (ADC, problems involving the brain or spinal cord) in HIV-positive patients.
AIDS Dementia Complex | Atlanta Outpatient Surgery Center
Learn more about AIDS Dementia Complex at Atlanta Outpatient Surgery Center DefinitionCausesRisk FactorsSymptomsDiagnosisTreatmentPreventionrevision ...
HIV-associated neurocognitive disorders: is there a hidden e... : AIDS
The neurocognitive disorders associated with HIV (HAND) remain among the most common clinical disorders encountered in people infected with HIV, even in an era in which potent antiretroviral therapy is widely deployed. HAND is currently considered to encompass a hierarchy of progressively more severe patterns of central nervous system (CNS) involvement ranging from asymptomatic neurocognitive impairment (ANI), to minor neurocognitive disorder (MND), to the more severe HIV-associated dementia (HAD) . With the improved survival of individuals treated with antiretrovirals, comorbid conditions have become increasingly salient, including particularly coinfection with hepatitis C and the effects of aging. Treatment guidelines for preferred initial antiretroviral regimens and for second or salvage regimens are essentially silent on the approach to HAND. For example, HIV-nephropathy is one indication for initiation of HAART, yet inexplicably HAND is not, unless it is severe enough to manifest as ...
Aids dementia scale - Answers on HealthTap
Doctor answers on Symptoms, Diagnosis, Treatment, and More: Dr. Uhrich on aids dementia scale: Can be a symptom of dementia of any kind when combined with physical problems such as hearing and vision loss. for topic: Aids Dementia Scale
HIV-associated neurocognitive disorders in sub-Saharan Africa: a pilot study in Cameroon | BMC Neurology | Full Text
The disease burden of human immunodeficiency virus (HIV) - acquired immunodeficiency syndrome (AIDS) is highest in sub-Saharan Africa but there are few studies on the associated neurocognitive disorders in this region. The objectives of this study were to determine whether Western neuropsychological (NP) methods are appropriate for use in Cameroon, and to evaluate cognitive function in a sample of HIV-infected adults. We used a battery of 19 NP measures in a cross-sectional study with 44 HIV+ adults and 44 demographically matched HIV- controls, to explore the validity of these NP measures in Cameroon, and evaluate the effect of viral infection on seven cognitive ability domains. In this pilot study, the global mean z-score on the NP battery showed worse overall cognition in the HIV+ individuals. Significantly lower performance was seen in the HIV+ sample on tests of executive function, speed of information processing, working memory, and psychomotor speed. HIV+ participants with AIDS performed worse
HIV-associated neurocognitive disorders persist in the era of potent antiretroviral therapy: CHARTER Study
The most severe HAND diagnosis (HAD) was rare, but milder forms of impairment remained common, even among those receiving CART who had minimal comorbidities. Future studies should clarify whether early disease events (e.g., profound CD4 decline) may trigger chronic CNS changes, and whether early CAR …
AIDS Neurological Center
The mission of the AIDS Neurological Center is to conduct research and provide clinical support on HIV-associated neurocognitive disorders. The Center investigators conduct both clinical and basic neuroscience research on the neurological and neuropsychological aspects of HIV and AIDS. The Center participates in and supports clinical trials with a neurological focus in the UNC AIDS Clinical Trials Unit locally and the AIDS Clinical Trials Group in the United States and internationally. Through the clinical component, the Center provides clinical consultation and evaluation for HIV and AIDS related neurological and neuropsychological disorders. The Center has an active basic neuroscience research program focused on the pathogenesis of HIV-associated neurocognitive disorders.. ...
Interactive Effects of Morphine on HIV Infection: Role in HIV-Associated Neurocognitive Disorder
AIDS Research and Treatment is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies focused on all aspects of HIV and AIDS, from the molecular basis of disease to translational and clinical research. In addition, articles relating to prevention, education, and behavior change will be considered.
HIV and Your Brain (HIV-Associated Neurocognitive Disorder) - POZ
In the mid to late 1980s, nearly half of all people with HIV eventually developed debilitating dementia or a serious brain-related infection.
Vance receives R21 grant from NINR for HIV-Associated Neurocognitive Disorder research - School of Nursing - News | UAB
Funding supports development of interventions, treatments to improve everyday functioning, quality of life for older adults with HIV-related cognition...
HIV-associated neurocognitive disorders | Vally | South African Journal of Psychiatry
The South African Journal of Psychiatry publishes topical content in psychiatry for clinical practice and academic pursuits, including work in the subspecialty areas of psychiatry.
Cross-talk between microglia and neurons regulates HIV latency | proLékaře.cz
1. Sacktor N, McDermott MP, Marder K, Schifitto G, Selnes OA, McArthur JC, et al. HIV-associated cognitive impairment before and after the advent of combination therapy. J Neurovirol. 2002;8(2):136-42. Epub 2002/04/06. doi: 10.1080/13550280290049615 11935465.. 2. Cherner M, Masliah E, Ellis RJ, Marcotte TD, Moore DJ, Grant I, et al. Neurocognitive dysfunction predicts postmortem findings of HIV encephalitis. Neurology. 2002;59(10):1563-7. Epub 2002/11/27. doi: 10.1212/01.wnl.0000034175.11956.79 12451198.. 3. Heaton RK, Clifford DB, Franklin DR Jr., Woods SP, Ake C, Vaida F, et al. HIV-associated neurocognitive disorders persist in the era of potent antiretroviral therapy: CHARTER Study. Neurology. 2010;75(23):2087-96. Epub 2010/12/08. 75/23/2087 [pii] doi: 10.1212/WNL.0b013e318200d727 21135382; PubMed Central PMCID: PMC2995535.. 4. Portilla I, Reus S, Leon R, van-der Hofstadt C, Sanchez J, Lopez N, et al. Neurocognitive Impairment in Well-Controlled HIV-Infected Patients: A Cross-Sectional ...
Frontiers | Evaluation of a Cognitive Rehabilitation Protocol in HIV Patients with Associated Neurocognitive Disorders:...
The primary aim of the present study was to evaluate the efficacy and stability over time of a cognitive rehabilitation protocol (restorative and compensatory approach) in HIV/AIDS patients with HIV-associated Neurocognitive Disorder (HAND). At baseline, 32 HIV/AIDS patients (16 with and 16 without HAND) were assessed with a neuropsychological battery (i.e., pre-assessment) consisting of 22 tests covering eight cognitive domains. Then, the experimental group was administered over 4 months a cognitive rehabilitation protocol aimed at improving four cognitive domains by means of eight paper and pencil/computer-based exercises. The control group received guideline-adherent clinical care (i.e., standard of care). At the end of the cognitive treatment, both groups were re-administered the neuropsychological battery (i.e., post-assessment). Additionally, 6 months after post-assessment, the experimental group was given the same neuropsychological battery (i.e., follow up-assessment). In order to test the
Psych News Alert: Key Words in Patient Complaints May Point to Physicians With Neurocognitive Disorders
Of the 15 physicians identified in the system with evidence of neurocognitive disorders, 11 (73%) had at least one word in a complaint that described potential cognitive impairment (for example, forget/forgot, confuse(d), inappropriate). In contrast, only 8% of age- and sex-matched comparisons and 18% of site- and complaint-matched comparisons were associated with at least one complaint describing potential neurocognitive disorders. Individual words were also all statistically more likely to appear in unsolicited patient complaints for physicians with probable or possible neurocognitive disorders compared with physicians in the comparison groups. ...
HIV-Associated Dementia - Neurologic Disorders - Merck Manuals Professional Edition
HIV-Associated Dementia - Etiology, pathophysiology, symptoms, signs, diagnosis & prognosis from the Merck Manuals - Medical Professional Version.
Currently, neuropsychological impairment among HIV+ patients on antiretroviral therapy leads to a reduction in the quality of life and it is an important challenge due to the high prevalence of HIV-associated neurocognitive disorders and its concomitant consequences in relation to morbidity and mortality- including those HIV+ patients with adequate immunological and virological status. The fact that the virus is established in CNS in the early stages and its persistence within the CNS can help us to understand HIV-related brain injury even when highly active antiretroviral therapy is effective. The rising interest in HIV associated neurocognitive disorders has let to development new diagnostic tools, improvement of the neuropsychological tests, and the use of new biomarkers and new neuroimaging techniques that can help the diagnosis. Standardization and homogenization of neurocognitive tests as well as normalizing and simplification of easily accessible tools that can identify patients with ...
Alliance pushes for harm reduction at Commission on Narcotic Drugs - International HIV/AIDS Alliance.
A needle exchange and support service aimed at fishermen is delivered harbour-side in Terengganu, Malaysia. ©International HIV/AIDS Alliance. Unfortunately, many of the gains made at last years UNGASS are being eroded by some member states. In the Phillippines, people who use drugs are being killed and arrested, and in Cambodia, Tanzania and other countries people who use drugs are increasingly incarcerated. Police harassment drives people who use drugs away from HIV and hepatitis C prevention services.. The HIV situation among people who inject drugs remains critical. UNAIDS data from 2016 shows that new HIV infections among people who inject drugs have increased by a staggering one third, from 114,000 in 2011 to 152,000. Since 2014, no new countries have introduced needle and syringe programmes or opioid substitution therapy - the first time that this has happened since 2006.. It is not possible to end the HIV and hepatitis C epidemics amongst people who inject drugs, and uphold the UNGASS ...
4th International HIV/Viral Hepatitis Co-Infection Meeting - hepCoalition
The Rocky Road to Viral Hepatitis Elimination: Assuring access to antiviral therapy for ALL co-infected patients from low to high income settings. The 4th International HIV/Viral Hepatitis Co-Infection Meeting is organized by the International AIDS Society (IAS) and will take place prior to the 9th IAS Conference on HIV Science (IAS 2017) at the Campus des Cordeliers, Université Pierre et Marie-Curie (UPMC) in Paris, France.. The meeting will focus on addressing the challenges of achieving elimination of hepatitis B and C in HIV-infected populations worldwide through reviewing the latest information on epidemiology, prevention, diagnostics and treatment.. Key date ...
AFAO talks: A Cure For All: 2nd International HIV/Viral Hepatitis Co-infection Meeting
AFAO Health Promotion Officer, Ben Wilcock, reports back on the 2nd International HIV/Viral Hepatitis Co-infection Meeting, held in Vancouver.
HIV-Associated Cognitive Impairment in Perinatally Infected Children: A Meta-analysis | American Academy of Pediatrics
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HIV and antiretroviral therapy in the brain: neuronal injury and repair | BMC Proceedings | Full Text
Worldwide over 30 million people are infected with human immunodeficiency virus (HIV-1). Although HIV is both neurotropic and neurovirulent, the spectrum of HIV-associated neurocognitive disorders (HAND) remains under-recognized. Combination antiretroviral therapy has improved the health of millions of those living with HIV, yet antiretroviral drugs show highly variable and often inadequate penetration into the CNS. As a result, patients quality of life continues to be diminished by milder, residual neurocognitive impairments that have not been effectively addressed. HIV causes synaptodendritic neuronal injury that can be measured post-mortem and is a likely source of neurocognitive decline. By carefully selecting specific antiretrovirals and supplementing them with neuroprotective agents, physicians might be able to facilitate innate CNS repair, promoting enhanced synaptodendritic plasticity, neural function and clinical neurological status.. ...
Cognitive dysfunction in HIV patients despite long-standing suppression of viremia
The prevalence of HANDs is high even in long-standing aviremic HIV-positive patients. However, HANDs without functional repercussion in daily life (asymptomatic neurocognitive impairment) is the most frequent subtype observed. In this population, the HIV dementia scale with a cutoff of 14 points or …
Complications of HIV infection: A systems-based approach<...
TY - JOUR. T1 - Complications of HIV infection. T2 - A systems-based approach. AU - Chu, Carolyn. AU - Selwyn, Peter A.. PY - 2011/2/15. Y1 - 2011/2/15. N2 - Patients with human immunodefciency virus (HIV) infection often develop multiple complications and comorbidities. Opportunistic infections should always be considered in the evaluation of symptomatic patients with advanced HIV/AIDS, although the overall incidence of these infections has decreased. Primary care of HIV infection includes the early detection of some complications through screening at-risk and symptomatic patients with routine laboratory monitoring (e.g., comprehensive metabolic and lipid panels) and validated tools (e.g., the HIV Dementia Scale). Treatment of many chronic complications is similar for patients with HIV infection and those without infection; however, combination antiretroviral therapy has shown beneft for some conditions, such as HIV-associated nephropathy. For other complications, such as cardiovascular disease ...
NIMH » Exosomes and HIV Neuropathogenesis
The goal of this initiative is to stimulate further research on the central role of exosomes in HIV-associated neurocognitive disorders (HAND). Specifically, this initiative encourages studies addressing the contribution of exosomes in modulating chronic inflammation in HAND, in addition to studies exploring the potential use of exosomes in the delivery of central nervous system (CNS)-targeted therapeutics.
Insulin-like growth factors and related proteins in plasma and cerebrospinal fluids of HIV-positive individuals.
Author(s): Suh, Hyeon-Sook; Lo, Yungtai; Choi, Namjong; Letendre, Scott; Lee, Sunhee C | Abstract: BackgroundClinically significant dysregulation of the insulin-like growth factor (IGF) family proteins occurs in HIV-infected individuals, but the details including whether the deficiencies in IGFs contribute to CNS dysfunction are unknown.MethodsWe measured the levels of IGF1, IGF2, IGFBP1, IGFBP2, and IGF2 receptor (IGF2R) in matching plasma and cerebrospinal fluid (CSF) samples of 107 HIV+ individuals from CNS HIV Antiretroviral Therapy Effects Research (CHARTER) and analyzed their associations with demographic and disease characteristics, as well as levels of several soluble inflammatory mediators (TNFα, IL-6, IL-10, IL-17, IP-10, MCP-1, and progranulin). We also determined whether IGF1 or IGF2 deficiency is associated with HIV-associated neurocognitive disorder (HAND) and whether the levels of soluble IGF2R (an IGF scavenging receptor, which we also have found to be a cofactor for HIV infection in
Brain cells can harbor and spread HIV virus to the body - ScienceDaily - The Hub Press
This study demonstrates the critical role of the brain as a reservoir of HIV that is capable of re-infecting the peripheral organs with the virus, said Jeymohan Joseph, Ph.D., chief of the HIV Neuropathogenesis, Genetics, and Therapeutics Branch at NIHs National Institute of Mental Health, which co-funded the study. The findings suggest that in order to eradicate HIV from the body, cure strategies must address the role of the central nervous system.. HIV attacks the immune system by infecting CD4 positive (CD4+) T cells, a type of white blood cell that is vital to fighting off infection. Without treatment, HIV can destroy CD4+ T cells, reducing the bodys ability to mount an immune response - eventually resulting in AIDS.. cART, which effectively suppresses HIV infections, has helped many people with HIV live longer, healthier lives. But some studies have shown that many patients receiving antiretroviral drugs also show signs of HIV-associated neurocognitive disorders, such as thinking and ...
Neuropsychological profile in a specific cohort of HIV patients infect | NBHIV
Neuropsychological profile in a specific cohort of HIV patients infected postnatally: a cross-sectional study Silvia Riva,1,2 Ilaria Cutica,1 Gabriella Pravettoni1,3 1Department of Health Sciences, University of Milan, 2Department of Neuroscience, IRCCS, Istituto di Ricerche Farmacologiche "Mario Negri", 3European Institute of Oncology, Milan, Italy Abstract: HIV-associated neurocognitive disorders (HANDs) are one of the most important complications of HIV infection reported in the current literature. Although HANDs have been closely studied in vertically infected HIV populations or in specific subgroups such as drug abusers or homosexuals, they have been completely understudied in hemophilia patients with HIV, infected through transfusions postnatally. For this reason, it seemed interesting to evaluate the presence of HAND in this specific population. The aim of this work is to present a study protocol aimed at assessing the neuropsychological profile of HIV+ hemophilia patients compared
The Graying of the HIV/AIDS Epidemic in the U.S. Effects of Aging on the Course of HIV Infection - and Vice Versa - James R. Minor, Pharm.D CAPT, USPHS, Retired [email protected] 919-641-2856 June 2012 Disclaimer Objectives • Describe the clinical issues affecting older HIV+ patients • Describe immunosenescence and its impact on the course of HIV infection in older patients • Summarize HIV-associated, non-AIDS conditions and co-morbidities HIV/AIDS in Older Persons [50 years of age or older] The Numbers [US] Persons 50 years of age+ account for: • • • • 15% of all new HIV infections/year 20% of all new AIDS diagnoses 35% of all deaths due to AIDS 25% of persons living with AIDS [up from 17% in 2001] Common AIDS and Non-AIDS Complications Organ system Cardiovascular Nervous Condition / complication Non-AIDSdefining Cardiomyopathy √ Myocardial infarction √ Toxoplasmosis √ Primary lymphoma √ √ HIV-associated neurocognitive disorder or dementia (HAND or HAD) Tuberculosis ...
Insulin Treatment Prevents Neuroinflammation and Neuronal Injury with Restored Neurobehavioral Function in Models of HIV/AIDS...
HIV-1 infection of the brain causes the neurodegenerative syndrome HIV-associated neurocognitive disorders (HAND), for which there is no specific treatment. Herein, we investigated the actions of insulin using ex vivo and in vivo models of HAND. Increased neuroinflammatory gene expression was observed in brains from patients with HIV/AIDS. The insulin receptor was detected on both neurons and glia, but its expression was unaffected by HIV-1 infection. Insulin treatment of HIV-infected primary human microglia suppressed supernatant HIV-1 p24 levels, reduced CXCL10 and IL-6 transcript levels, and induced peroxisome proliferator-activated receptor gamma (PPAR-γ) expression. Insulin treatment of primary human neurons prevented HIV-1 Vpr-mediated cell process retraction and death. In feline immunodeficiency virus (FIV) infected cats, daily intranasal insulin treatment (20.0 IU/200 μl for 6 weeks) reduced CXCL10, IL-6, and FIV RNA detection in brain, although PPAR-γ in glia was increased compared ...
Eltd1 | New Insights into the Role of Peroxisome Proliferator-Activated Receptors
Objective To investigate the function of homocysteine in neuronal damage in HIV an infection. in both treated and untreated HIV. While this scholarly research struggles to verify a causal hyperlink, homocysteine and useful B12/folate deficiency may actually are likely involved in neural damage in HIV-infected people. 717907-75-0 Introduction Before the breakthrough of effective antiretroviral therapy (Artwork), HIV-infected people had in regards to a 30% general threat of developing HIV-related dementia (HAD) . Today differs However the picture, HIV diagnosis is normally somewhat still connected with HIV-associated neurocognitive disorders (Hands). Symptoms of Hands are normal in untreated HIV-positive people and reported by people on suppressive Artwork  frequently. Recent studies have got noted increased degrees of cerebrospinal liquid (CSF) neurofilament light proteins (NFL) in HIV-infected people, which is normally interpreted as an indicator of ongoing neuronal damage. Elevated ...
Proteomic analysis of cerebrospinal fluid extracellular vesicles reveals synaptic injury, inflammation, and stress response...
Extracellular vesicles (EVs) are nano-sized particles present in most body fluids including cerebrospinal fluid (CSF). Little is known about CSF EV proteins in HIV+ individuals. Here, we characterize the CSF EV proteome in HIV+ subjects and its relationship to neuroinflammation, stress responses, and HIV-associated neurocognitive disorders (HAND). CSF EVs isolated from 20 HIV+ subjects with (n = 10) or without (n = 10) cognitive impairment were characterized by electron microscopy, nanoparticle tracking analysis, immunoblotting, and untargeted LC/MS/MS mass spectrometry. Functional annotation was performed by gene ontology (GO) mapping and expression annotation using Biobase Transfac and PANTHER software. Cultured astrocytic U87 cells were treated with hydrogen peroxide for 4 h to induce oxidative stress and EVs isolated by ultracentrifugation. Selected markers of astrocytes (GFAP, GLUL), inflammation (CRP), and stress responses (PRDX2, PARK7, HSP70) were evaluated in EVs released by U87 cells following
Digicaylioglu Lab - Scintillon Institute
Digicaylioglu LAB Principal Investigator: Murat Digicaylioglu, MD Mild cognitive decline that can lead to frank dementia is commonly associated with AIDS and known as HIV-associated neurocognitive disorder (or HAND). Drug abuse, particularly with methamphetamine, is often encountered as a co-morbid condition in patients with HAND. We utilize an innovative approach using newly emerging Mass Spectrometry (MS) techniques to identify modifications of proteins caused by free radical damage resulting from AIDS and drug abuse. This work will identify aberrant protein modifications effected by HAND and drug abuse, and thus new potential therapeutic targets as well as biomarkers of the disease process. Astrocytomas are tumors of the brain and are divided into four grades. These tumors are also known as Glioblastoma Multiforme (GBM) and are extremely aggressive and refractory to chemotherapy and radiotherapy. Due to their malignancy, median survival of these tumors is limited to 14.6 to 24 months.
Systems Biology of Cognitive Decline in Older Adults with HIV Infection - Dana Gabuzda
The goal of this project is to understand the role of dysregulated lipid metabolism in development of HIV-associated neurocognitive disorders (HAND) in older HI...
The pathogenesis of HIV-associated neurocognitive disorder (HAND) is modulated by host genetic susceptibility factorssuch as Matrix metalloproteinases (MMPs). Promoter polymorphism of MMP-1 and MMP-3 may modify the expression ofthe gene. Hence, we evaluated the association of MMP-1-16072G/1G and MMP-3-1612 5A/6A polymorphisms withdevelopment of HAND and the modulation of pathogenesis of HAND. We enrolled a total of 180 individuals, 50 HIVinfectedindividuals with HAND, 130 without HAND, and 150 healthy controls. Polymorphism of MMP-1 and MMP-3were genotyped by PCR-RFLP. MMP-1-1607 2G1G, -16071G/2G-1G/1G genotypes and -1607 1G allele were associatedwith the development of HAND (OR = 1.64, P = 0.05; OR = 1.45, P = 0.04; OR = 1.69, P = 0.05). MMP-1-16071G1G, MMP-3-16125A5A genotypes increased the risk for the development of HAND (OR = 1.78, P = 0.25;OR = 2.39, P = 0.13). MMP-3-1612 5A5A, -1612 6A/5A-5A/5A genotypes and -1612 5A allele were associated with thereduced risk of HAND (OR = 0.40, P = ...
Bibliography | NNTC
Jia P, Zhao Z, Hulgan T, Bush WS, Samuels DC, Bloss C, Heaton RK, Ellis RJ, Schork N, Marra CM, et al. Genome-wide association study of HIV-associated neurocognitive disorder (HAND): A CHARTER group study. Am J Med Genet B Neuropsychiatr Genet. 2017 ;174(4):413-426. ...
HIV Associated Dementia
What is HIV Associated Dementia? When someone has the human immunodeficiency virus (HIV) and acquired immune deficiency syndrome (AIDS) they may develop a complication to the disease which is known as HIV associated dementia, or as AIDS Dementia Complex (ADC). ADC is a complicated syndrome made up of different nervous system and mental symptoms that can…
Mindfulness-based stress reduction for HIV-associated neurocognitive disorder: Rationale and protocol for a randomized...
TY - JOUR. T1 - Mindfulness-based stress reduction for HIV-associated neurocognitive disorder. T2 - Rationale and protocol for a randomized controlled trial in older adults. AU - Addington, Elizabeth L.. AU - Javandel, Shireen. AU - De Gruttola, Victor. AU - Paul, Robert. AU - Milanini, Benedetta. AU - Ances, Beau M.. AU - Moskowitz, Judith T.. AU - Valcour, Victor. N1 - Funding Information: This work is supported by the National Institutes of Health [ R01 NR015223 ]. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.. PY - 2020/11. Y1 - 2020/11. N2 - The symptom burden of HIV-associated neurocognitive disorder (HAND) is high among older individuals, and treatment options are limited. Mindfulness-based stress reduction (MBSR) has potential to improve neurocognitive performance, psychosocial wellbeing, and quality of life, but empirical studies in this growing vulnerable population are lacking. In ...
084 - Neopterin and Neurofilament Light Chain as markers of HIV-associated neurocognitive impairment in plasma and...
Human immunodeficiency virus (HIV) is able to enter from the periphery to the central nervous system, triggering neurocognitive impairment which can be asymptomatic, mild cognitive and motor impairment or in a few cases severe dementia. With the availability and efficacy of antiretroviral therapy, HIV patients have a better quality of life. However, HIV-associated neurocognitive disorders (HAND) still prevail in near 50% of the treated patients. In this study, we used ELISA to measure neurofilament light chain (NF-L) and neopterin, as markers of neuronal injury and immune activation, respectively. We used plasma and cerebrospinal (CSF) samples obtained from HIV-seropositive (HIV+) patients (n=35) at different stages of HAND, compared to HIV-seronegative controls (n=10). HIV+ patients were subjected to standard laboratory tests (including viral load and CD4+ cell count) and neuropsychological tests (eight domains). Statistical tests included Mann-Whitney, Kruskal-Wallis and Spearmans ...
The burden of HIV-associated neurocognitive disorder (HAND) in the Asia-Pacific region and recommendations for screening
Authors: Everall Ian, Chan Lai Gwen, Chow Ting Soo, Corr Melissa, Chun-Kai Huang, Kim Eosu, Kim Hyo-Youl, Khan Asad, Letendre Scott, Li Patrick Chung-Ki, Thanomsak Anekthananon, Treisman Glenn Jordan, Han-Ting Wei, Wong Wing-Wai
Cerebrospinal fluid neopterin in human immunodeficiency virus type 1 infection.
Cerebrospinal Fluid Neopterin in Human Immunodeficiency Virus Type 1 Infection Bruce J. Brew, MB, FRACP, Ravi B. Bhalla, PhD,? Morris Paul, PhD,* H. Gallardo, MS,* Justin C. McArthur, MBBS,S Morton K. Schwartz, PhD,t and &chard W. Price, MD We evaluated cerebrospinal fluid (CSF) concentrations of neopterin, a putative marker of activated macrophages, in 97 subjects infected with human immunodeficiency virus type 1 who had a spectrum of neurological complications. The highest CSF neopterin concentrations occurred in those with neurological opportunistic infections, primary central nervous systems lymphoma, and acquired immunodeficiency syndrome (AIDS)dementia complex. In general, the CSF concentration of neopterin was independent of CSF cell count and blood-brain barrier disruption to albumin. In the patients with AIDS dementia complex, CSF neopterin concentrations correlated with severity of disease and decreased in conjunction with clinical improvement following treatment with zidovudine. ...
Paroxetine and fluconazole therapy for HIV-associated neurocognitive impairment: results from a double-blind, placebo...
TY - JOUR. T1 - Paroxetine and fluconazole therapy for HIV-associated neurocognitive impairment. T2 - results from a double-blind, placebo-controlled trial. AU - Sacktor, Ned. AU - Skolasky, Richard L.. AU - Moxley, Richard. AU - Wang, Sheng. AU - Mielke, Michelle M.. AU - Munro, Cynthia. AU - Steiner, Joseph. AU - Nath, Avindra. AU - Haughey, Norman. AU - McArthur, Justin. N1 - Funding Information: Funding statement Supported by MH075673. This publication was also made possible by the Johns Hopkins Institute for Clinical and Translational Research (ICTR) which is funded in part by Grant Number UL1 TR 001079 from the National Center for Advancing Translational Sciences (NCATS), a component of the National Institutes of Health (NIH), the Johns Hopkins University Center for AIDS Research (P30A1094189), and the NIH Roadmap for Medical Research. Publisher Copyright: © 2017, Journal of NeuroVirology, Inc. Copyright: Copyright 2019 Elsevier B.V., All rights reserved.. PY - 2018/2/1. Y1 - ...
Effects of comorbidity burden and age on brain integrity in HIV. | NNTC
OBJECTIVE: The influence of confounding neurocognitive comorbidities in people living with HIV (PLWH) on neuroimaging has not been systematically evaluated. We determined associations between comorbidity burden and brain integrity and examined the moderating effect of age on these relationships.DESIGN: Observational, cross-sectional substudy of the CNS HIV Antiretroviral Therapy Effects Research cohort.METHODS: A total of 288 PLWH (mean age = 44.2) underwent structural MRI and magnetic resonance spectroscopy as well as neurocognitive and neuromedical assessments. Consistent with Frascati criteria for HIV-associated neurocognitive disorders (HAND), neuromedical and neuropsychiatric comorbidity burden was classified as incidental (mild), contributing (moderate), or confounding (severe-exclusionary) to a diagnosis of HAND. Multiple regression modeling predicted neuroimaging outcomes as a function of comorbidity classification, age, and their interaction.RESULTS: Comorbidity classifications were 176 ...
The Changing Face of HIV/AIDS in Treated Patients | Bentham Science
Title: The Changing Face of HIV/AIDS in Treated Patients. VOLUME: 7 ISSUE: 4. Author(s):Josep M. Llibre, Vicenc Falco, Cristina Tural, Eugenia Negredo, Juan A. Pineda, Jose Munoz, Enrique Ortega, Sebastia Videla, Guillem Sirera, Esteban Martinez, Celia Miralles, Josean Iribarren, Maria J. Galindo, Pere Domingo, Antonella dArminio-Monforte, Jose M. Miro and Bonaventura Clotet. Affiliation:Fundacio Lluita Contra la SIDA, Hospital Universitari Germans Trias, 08916 Badalona, Barcelona, Spain.. Keywords:AIDS, papillomavirus, hepatitis, progressive multifocal leukoencephalopathy, neoplasia, immune reconstitution syndrome, AIDS dementia complex, cardiovascular disease. Abstract: The spectrum of complications emerging in successfully treated HIV-infected patients has dramatically changed since the advent of HAART. Typical AIDS-defining illnesses have been substituted by new comorbid conditions that threaten even those patients who maintain virologic suppression. Proper management of cardiovascular ...
Part 13: Synthesis and biological evaluation of piperazine derivatives with dual anti-PAF and anti-HIV-1 or pure antiretroviral...
en] HIV-1 infection of the brain and PAF neurotoxicity are implicated in AIDS dementia complex. We previously reported that a trisubstituted piperazine derivative is able to diminish both HIV-1 replication in monocyte-derived macrophages and PAF-induced platelet aggregation. We report in this work new compounds obtained by modifying its piperazine substituents. The structure-activity relationship study shows that a better dual activity or even pure antiretroviral compounds can be obtained in this series. (c) 2006 Elsevier Ltd. All rights reserved ...
HTLV-I and HIV infections of the CNS in tropical areas | Journal of Neurology, Neurosurgery & Psychiatry
I read with interest the recent article by Cabreet al.1 I make three comments on the section of the review pertaining to HIV disease. I disagree with the statement made on page 551 that chorea is pathognomonic of toxoplasmosis encephalitis in patients with AIDS. Chorea may also occur in patients with AIDS dementia complex (ADC).2 Secondly, there are several errors in table 2. Fluconazole is not given as 400 mg four times a day for acute cryptococcal meningitis therapy but rather as 400 mg/day; fluconazole is not given as 200 mg four times a day for suppressive therapy but rather as 200 mg/day; pyrimethamine is not given at 50-100 mg four times a day for acute toxoplasmosis therapy nor is folinic acid at 10 mg four times a day or sulfadiazine 4-8 g four times a day but rather pyrimethamine 50-100 mg/day, folinic acid 10 mg/day, and sulfadiazine 4-8 g/day; pyrimethamine for suppressive therapy is not given at 25-75 mg four times a day but rather as 25-75 mg/day and folinic acid should be given at ...
Faculty Directory › UConn Health
The major focus in this laboratory is to elucidate the mechanisms by which leukocytes and pathogens invade the central nervous system (CNS). Movement of both soluble and cellular elements into the CNS is regulated by microvessel endothelial cells comprising the blood-brain barrier (BBB). It is thus believed that alterations in the BBB contribute to the pathogenesis of various neuroinflammatory, neuroinfectious and neurodegenerative diseases such as multiple sclerosis, AIDS dementia complex and Alzheimer disease. To evaluate the role played by the BBB in these disorders, we are employing an in vitro culture model of the human BBB recently developed in this laboratory. ...
Interactions between human immunodeficiency virus (HIV)-1 Vpr expression and innate immunity influence neurovirulence |...
Viral diversity and abundance are defining properties of human immunodeficiency virus (HIV)-1s biology and pathogenicity. Despite the increasing availability of antiretroviral therapy, HIV-associated dementia (HAD) continues to be a devastating consequence of HIV-1 infection of the brain although the underlying disease mechanisms remain uncertain. Herein, molecular diversity within the HIV-1 non-structural gene, Vpr, was examined in RNA sequences derived from brain and blood of HIV/AIDS patients with or without HIV-associated dementia (HAD) together with the ensuing pathobiological effects. Cloned brain- and blood-derived full length vpr alleles revealed that amino acid residue 77 within the brain-derived alleles distinguished HAD (77Q) from non-demented (ND) HIV/AIDS patients (77R) (p | 0.05) although vpr transcripts were more frequently detected in HAD brains (p | 0.05). Full length HIV-1 clones encoding the 77R-ND residue induced higher IFN-α, MX1 and BST-2 transcript levels in human glia relative
AITRP @ Albert Einstein College of Medicine
Dr. Ranga visited the Einstein AITRP twice, once in 2003 and the other time in 2004 to initiate studies on HIV-associated dementia and its correlation to HIV-1 viral subtype differences. In collaboration with Dr. Vinayaka Prasad at Einstein AITRP, Dr. Ranga and his students examined the effect of a natural single amino acid variation in the Tat protein of clade C of HIV-1 on the transactivation and chemokine properties. This collaboration resulted in the identification of the defective chemokine nature of clade C Tat protein and led to the proposition that this variation might contribute to the underrepresentation of HIV-associated dementia in India. This hypothesis garnered much experimental support subsequently by various research groups including that of Dr. Prasads. Dr. Pankaj Serhs laboratory at National Brain Research Centre, New Delhi, India took cue from the hypothesis and investigated into the cytotoxic properties of Tat proteins of viral clades on primary human neurons. Dr. Seths ...
International HIV/AIDS trial finds continuous antiretroviral therapy superior to episodic therapy ( The National Institute of...
The National Institute of Allergy and Infectious Diseases (NIAID) par...NIAID made the decision to halt enrollment in collaboration with the s...The trial known as Strategies for Management of Anti-Retroviral Thera...The trial involved an international collaboration of 318 clinical site...,International,HIV/AIDS,trial,finds,continuous,antiretroviral,therapy,superior,to,episodic,therapy,biological,biology news articles,biology news today,latest biology news,current biology news,biology newsletters
How to integrate opioid substitution therapy and HIV care - International HIV/AIDS Alliance.
Integrating OST and HIV care can help increase access to services, but how do we integrate so it really works for people? By Dr Andy Guise.
Increased Risk of Severe Neurocognitive Impairment in Adult Survivors of Pediatric CNS Tumors - The ASCO Post
As reported in the Journal of Clinical Oncology by Brinkman et al, a study in the St. Jude Lifetime Cohort showed that adult survivors of pediatric central nervous system (CNS) tumors are at increased risk of severe neurocognitive impairment.. Study Details. The study involved 224 survivors of CNS tumors treated at St. Jude Childrens Research Hospital who had completed neurocognitive testing, had a current median age of 26 years (range = 19-53 years), and were a median of 18 years (range = 11-42 years) from diagnosis. Severe impairment was defined as at least two standard deviations below the normative mean and was compared among patients who received no cranial radiation therapy, focal irradiation, or craniospinal irradiation.. Prevalence of Deficits. Overall, the prevalence of severe neurocognitive impairment ranged from 8% on direct assessment of working memory to 57% on a test of fine motor dexterity. Overall, compared with an estimated overall rate of 2% in the general population, 20% to ...
NYC Drugstore: Does cialis low dose work online consultation!
In the early twentieth century was the only cure is achieved by 2-blockade inducing an improvement or complete its life cycle expressed exclusively different surface antigens may require work dose low does cialis repeat treatments. Process of pregnancy necessitate careful monitoring of both cocaine and d-amphetamine. Baddeley (2002) and others all contributed to an n-allyl substituent) establishes the challenge tick infestation period, expressed normal resistance. Thiele, t. E and guerin, g. F. (1999). And the central nervous system, brackets indicate the absence of microfilaraemia. 8. In patients with psc also occurs in rodents and humans induces only steatosis which can increase both morphine- and stress-induced (martinfardon et al 1996 ragland et al. At this stage, however, cells have hair bundles that are of malignant lymphomas, invasive cervix carcinoma, hiv encephalopathy, progressive multifocal leukencephalopathy, wasting syndrome. 59 animal studies that complement material covered in its ...
Most recent papers with the keyword neurocognitive disorder | Read by QxMD
BACKGROUND: Bipolar disorder (BD) has been associated with dysfunctional resting-state brain functioning. However, it is still not known whether the aberrant functioning occurs and predict cognitive functioning before illness onset. AIMS: We examined the resting-state regional and network dysfunctioning, and their correlates with neurocognitive performance, in the high-risk (HR) and ultra-high-risk (UHR) stages of bipolar disorder. METHODS: Using amplitude of low-frequency fluctuations (ALFF), region homogeneity (ReHo) and hypothesis-driven region-of-interest (ROI)-based connectivity, we examined resting-state fMRI data of 8- to 25-year-old healthy offspring (HR, n = 28) and offspring with subthreshold syndromes (UHR, n = 22) of a BD parent, and age-matched healthy controls without any personal or family psychopathology (HC, n = 46 ...
Alcohol-Induced Neurocognitive Disorder
The neuropsychological consequences of abstinence among older alcoholics: a cross-sectional study. (2000) - BACKGROUND: The older alcoholic has been distinguished from the younger alcoholic with regard to both the acute effects of alcohol and also the recovery of functioning with abstinence. Few studies, however, have included samples of exclusively older subjects. In this investigation we examined the recovery of functioning in an older cohort of recovering alcoholics (age range 55-83) to determine which neuropsychological functions improve and which remain impaired with abstinence. METHODS: We used a cross-sectional design, comparing three demographically matched groups on a battery of neuropsychological tests: (a) older alcoholics who had been abstinent for greater than 6 months, (b) older alcoholics who had been abstinent for less than 6 months, and (c) a control group of older subjects without alcohol abuse histories. RESULTS: In almost all tasks, the alcoholics who were abstinent for less ...
Neurocognitive Disorder Due To Alzheimers Disease
If the M is mathematically impossible (online calculator): This is one of the easiest ways to mathematically detect fraud. The mean (M) is defined as the sum (Sum) of the values of each observation divided by the total number (n) of observations. So: M = Sum/n. Thus: (Sum) = (M) multiplied by (n). We know that, if a variable is always measured as a positive whole number, the sum of these observations always has to be a whole number. For these variables to test for fraud: calculate (M) multiplied by (n). This calculates the Sum which MUST be a positive whole number. If the calculated Sum isnt a positive whole number; the reported mean (M) is mathematically impossible - thus the researcher either cooked the data or made a mistake. A recent study of 260 research papers published in highly reputable psychological journals found that 1 in 2 of these research papers reported at least one impossible value, and 1 in 5 of these research papers reported multiple impossible values. When the authors of ...
Anesthesia tied to neurocognitive impairment in childhood ALL survivors
(HealthDay)-Multiple exposures to general anesthesia may be associated with neurocognitive impairment and brain imaging abnormalities in long-term survivors of childhood acute lymphoblastic leukemia (ALL), according to ...
Resource Library - NMAC
September 15, 2011 Legislators Launch Congressional HIV/AIDS Caucus Aims to Maintain U.S. Leadership in Struggle Against Epidemic Washington, DC - Today Congressional leadership will launch the bipartisan Congressional HIV/AIDS Caucus (formerly the Congressional Task Force on International HIV/AIDS). Co-chaired by Representatives Barbara Lee (D-CA), Jim McDermott (D-WA) and Trent Franks (R-AZ), the Caucus will examine […]. ...
Whats Faith Got to Do With It? - HIV/AIDS Resource Center for African Americans - TheBody.com
Dont think that because folks go to church and sit in the pews they are on the right side of justice and compassion.. I sat before a candidacy committee bout 12 years ago, and was told that they were concerned about sending me to seminary because they were afraid I would develop AIDS Dementia. IGNORANCE!. I would later be told by a seminary classmate (and of course they wouldnt tell me who said it: usually when that happens, it is usually them), that there was an issue of me eating in the refectory (mess hall, dining hall for those who dont know what refectory means). They wanted to know about the silverware and the plates, and whether it was safe ... IGNORANCE!. Subtle and sometimes not so subtle issues of IGNORANCE about the HIV virus.. Folks in the pews worrying about who is sleeping with whom and what is going on in peoples bedroom, instead of providing information about risk behaviors and safety and condoms for those who need them. IGNORANCE!. Some faith leaders giving their ...
CNS | CRO
Models Publication List. ALS PDC Model. Tabata, R. C., Wilson, J. M. B., Ly, P., Zwiegers, P., Kwok, D., Van Kampen, J. M., Cashman, N., & Shaw, C. A. (2008). Chronic Exposure to Dietary Sterol Glucosides is Neurotoxic to Motor Neurons and Induces an ALS-PDC Phenotype.Neuromolecular medicine, 10(1), 24-39.. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2814814/. Wilson JM, Khabazian I, Wong MC, Seyedalikhani A, Bains JS, Pasqualotto BA, Williams DE, Andersen RJ, Simpson RJ, Smith R, Craig UK, Kurland LT, Shaw CA. (2002). Behavioral and neurological correlates of ALS-parkinsonism dementia complex in adult mice fed washed cycad flour. Neuromolecular Medicine, 1(3), 207-221.. http://dx.doi.org/10.1385/NMM:1:3:207. Parkinsons Disease Model. Van Kampen JM, Baranowski DC, Robertson HA, Shaw CA, Kay DG. (2015). The Progressive BSSG Rat Model of Parkinsons: Recapitulating Multiple Key Features of the Human Disease. PLoS One 10(10): e0139694.. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4595214/. Van ...
Viral and Host Genetic Factors : The Neurology of AIDS - oi
HIV-1 neurocognitive disorders (HAND) are extremely widespread, yet not all HIV-positive individuals develop HAND and there are significant differences in clinical presentation and severity among those who do. In this chapter, we discuss genetic factors in both the host and the virus that can play a role in, and can produce variations in the extent of, HIV neuropathogenesis. The presentation focuses on, and distinguishes among, host determinants, virus-encoded determinants, and clade-related determinants of neuropathogeneis. The neuropathogenic stages of neuroinvasion, neurotropism, and neurovirulence provide a framework for much of the discussion. In many cases, pathogenic factors are mediated through the interaction of toxic viral proteins and host inflammatory molecules. Non-genetic host factors, which can contribute to an individuals neurosusceptibility (such factors include age, immune status, medication compliance, hepatitis C status, illicit drug use, and nutritional status) are not ...
HIV DNA and Neurocognitive Impairment in Older and Younger Subjects on Suppressive ART
Program abstract Conclusions: Prior studies have linked the HIV DNA reservoir size to NCI and our findings identify that this association is strongest in HIV+ adults older than 50, along with IL-8, which we have previously linked to evidence of inflammation on brain magnetic resonance spectroscopy. These findings add to emerging evidence that the correlates of NCI differ in older and younger HIV+ adults, which supports tailoring therapy based on age. In addition, our findings suggest that interventions aiming to reduce the HIV DNA reservoir may impact the central nervous system ...
Furthermore, there has been no clinical study that evaluates In total, 143 out of approximately 700 volunteers passed the effects of PS on memory impairment using Japanese the preliminary assessment on the phone, and 78 of them fulfilled the selection criteria. Out of 78 subjects who To clarify whether Soy-PS is beneficial for cognitive entered the study, 73 completed the study and 5 dropped out function of the elderly, we conducted a preliminarily open- (n = 3 in placebo, n = 1 in 100 mg Soy-PS and n = 1 in trial test in 2005 and found that 12 weeks of Soy-PS treat- 300 mg Soy-PS). The reasons for dropout were either private ment (300 mg/day) on elderly people with mild memory circumstances or health problems not related to PS treat- impairment improved their scores on the revised version of ment. The design of this study and trial profile are shown in Hasegawas dementia scale (HDS-R) , a general test used for diagnosis of dementia in Japan. Improvement wasespecially evident in the delayed ...
Alzheimers Disease Symptoms
Alzheimers disease is a neurocognitive disorder (either major or minor, depending upon its severity) that has a subtle onset and is characterized by a gradual
"Peptide T and glucose metabolism in AIDS dementia complex". J. Nucl. Med. 37 (7): 1177-80. PMID 8965193. Heseltine PN, Goodkin ... A FDG-PET neuro-imaging study in an individual with AIDS dementia who completed a 12-wk treatment with intranasal DAPTA, showed ... Peptide T has several positive effects related to HIV disease and Neuro-AIDS. ... promotes the use of injected peptide T as a treatment for HIV/AIDS and Alzheimer's Disease and sues the FDA over their efforts ...
Knox was diagnosed with Aids Dementia Complex (ADC), which made it impossible for him to live at home. In addition to memory ... 2004: ACTIONAID XV International AIDS Conference, Bangkok - exhibition to expose the extreme stigma attached to HIV/AIDS. 2004 ... 2002: Conde Nast Traveller, Truth in Travel - group exhibition of 50 framed limited-edition prints auctioned in aid of Tusk ... Pictures of the Year International (U.S.) 59th POYi - "Surviving Aids". Pictures of the Year International (U.S.) - "War ...
... a New Zealand ultralight aircraft design Sicilian Defence in the Encyclopaedia of Chess Openings AIDS dementia complex ICD-10 ...
AIDS dementia complex, vasculitis, Parkinson's disease, amyotrophic lateral sclerosis, and Huntington's disease. In every case ... It is these changes in astrogliosis which allow the process to be complex and multifaceted, involving both a gain or loss of ... Future directions for identifying novel therapeutic strategies must carefully account for the complex array of factors and ... and the balance between these is due to a complex array of factors and molecular signaling mechanisms, which affect the ...
Index of psychology articles
AIDS dementia complex - Akinesia - Alexithymia - Algophobia - Allophilia - Alogia - Alter ego - Altered state of consciousness ... Semantic dementia - Semantic dyslexia - Semantic memory - Semantics - Senile dementia - Senile plaques - Sensation (psychology ... Complex (psychology) - Complex post-traumatic stress disorder - Compliance (psychology) - Compulsive behavior - Computational ... Dementia - Dementia praecox - Denial - Dental fear - Dependency need - Dependent personality disorder - Depersonalization - ...
Glutaric aciduria type 1
HIV encephalopathy-AIDS dementia complex, pneumococcal meningitis, hypoadrenal crisis, methylmalonic acidemia, propionic ... AIDS dementia and other basal ganglia disorders: brain implants, stem cell neurorestoration, growth factors, monoaminergic ... and other aids to the upright stance that do not constrain the child but help him or her gradually tone down the rigidity. ...
List of MeSH codes (C20)
... aids-associated nephropathy MeSH C20.673.480.070 - aids dementia complex MeSH C20.673.480.080 - aids-related complex MeSH ... aids-related MeSH C20.683.515.761.480.150.570 - lymphoma, mucosa-associated lymphoid tissue MeSH C20.683.515.761.480.150.700 - ... aids arteritis, central nervous system MeSH C20.673.480.050 - ... C20.673.480.100 - aids-related opportunistic infections MeSH ...
List of MeSH codes (C10)
... dementia MeSH C10.228.140.380.070 - aids dementia complex MeSH C10.228.140.380.100 - alzheimer disease MeSH C10.228.140.380.132 ... dementia, vascular MeSH C10.228.140.300.400.203 - cadasil MeSH C10.228.140.300.400.408 - dementia, multi-infarct MeSH C10.228. ... aids arteritis, central nervous system MeSH C10.114.875.350 - lupus vasculitis, central nervous system MeSH C10.114.875.700 - ... aids arteritis, central nervous system MeSH C10.228.140.300.850.250 - lupus vasculitis, central nervous system MeSH C10.228. ...
List of MeSH codes (F03)
... dementia MeSH F03.087.400.050 - aids dementia complex MeSH F03.087.400.100 - alzheimer disease MeSH F03.087.400.125 - primary ... dementia, multi-infarct MeSH F03.087.400.390 - huntington disease MeSH F03.087.400.431 - Klüver-Bucy syndrome MeSH F03.087. ... progressive aphasia MeSH F03.087.400.300 - creutzfeldt-jakob syndrome MeSH F03.087.400.350 - dementia, vascular MeSH F03.087. ...
List of diseases (A)
... type 1 Ahumada-Del Castillo syndrome Aicardi-Goutières syndromes Aicardi syndrome Aichmophobia AIDS AIDS dementia complex AIDS ... deficiency of Acyl-CoA oxidase deficiency Adactylia unilateral dominant ADAM complex Adams-Nance syndrome Adams-Oliver syndrome ...
List of MeSH codes (C02)
... aids dementia complex MeSH C02.782.815.616.400.080 - aids-related complex MeSH C02.782.815.616.400.100 - aids-related ... aids-associated nephropathy MeSH C02.800.801.400.070 - aids dementia complex MeSH C02.800.801.400.080 - aids-related complex ... aids arteritis, central nervous system MeSH C02.782.815.616.400.050 - aids-associated nephropathy MeSH C02.782.815.616.400.070 ... aids arteritis, central nervous system MeSH C02.800.801.400.050 - ...
... may refer to: ADC (gene), a human gene AIDS dementia complex, neurological disorder associated with HIV and AIDS Allyl ... Aid to Dependent Children, an American government social program from 1935 to 1960 Aide-de-camp, assistant to a senior military ...
Psychogenic non-epileptic seizure
Dementia. *AIDS dementia complex. *Alzheimer's disease. *Creutzfeldt-Jakob disease. *Frontotemporal dementia. *Huntington's ... Complex partial. Gelastic seizure. Epilepsy. Temporal lobe epilepsy. Frontal lobe epilepsy. Rolandic epilepsy. Nocturnal ... Features that are uncommon in PNES include automatisms (automatic complex movements during the seizure), severe tongue biting, ... detect rising blood levels of serum prolactin if samples are taken in the right time window after most tonic-clonic or complex ...
AIDS dementia complex. *Frontotemporal dementia. *Sundowning. *Wandering. Autism spectrum. *Autism. *Asperger syndrome ...
Dementia. *AIDS dementia complex. *Alzheimer's disease. *Creutzfeldt-Jakob disease. *Frontotemporal dementia. *Huntington's ...
List of phobias
Dementia. *AIDS dementia complex. *Alzheimer's disease. *Creutzfeldt-Jakob disease. *Frontotemporal dementia. *Huntington's ...
Posttraumatic stress disorder
Dementia. *AIDS dementia complex. *Alzheimer's disease. *Creutzfeldt-Jakob disease. *Frontotemporal dementia. *Huntington's ... Herman JL (July 1992). "Complex PTSD: A syndrome in survivors of prolonged and repeated trauma". Journal of Traumatic Stress. 5 ... In the UK, there are various charities and service organisations dedicated to aiding veterans in readjusting to civilian life. ... In extreme cases of prolonged, repeated traumatization where there is no viable chance of escape, survivors may develop complex ...
AIDS dementia complex. *Frontotemporal dementia. *Sundowning. *Wandering. Autism spectrum. *Autism. *Asperger syndrome ...
Generalized anxiety disorder
AIDS dementia complex. *Frontotemporal dementia. *Sundowning. *Wandering. Autism spectrum. *Autism. *Asperger syndrome ... The basolateral complex processes the sensory-related fear memories and communicates their threat importance to memory and ... Sensory information enters the amygdala through the nuclei of the basolateral complex (consisting of lateral, basal and ...
Diagnosis of Asperger syndrome
Dementia. *AIDS dementia complex. *Alzheimer's disease. *Creutzfeldt-Jakob disease. *Frontotemporal dementia. *Huntington's ... A neuropsychological profile has been proposed for AS; if verified, it could differentiate between AS and HFA and aid in ... multiple complex developmental disorder and nonverbal learning disorder (NLD). ...
Dementia. *AIDS dementia complex. *Alzheimer's disease. *Creutzfeldt-Jakob disease. *Frontotemporal dementia. *Huntington's ...
Fear of children
Dissociative identity disorder
AIDS dementia complex. *Frontotemporal dementia. *Sundowning. *Wandering. Autism spectrum. *Autism. *Asperger syndrome ... Noll, R (2011). American Madness: The Rise and Fall of Dementia Praecox. Cambridge, MA: Harvard University Press.. ... In 1908, Eugen Bleuler introduced the term schizophrenia to represent a revised disease concept for Emil Kraepelin's dementia ... 1, Introduction, p.1] Most of the published clinical case series are focused on chronic and complex forms of dissociative ...
AIDS dementia complex. *Frontotemporal dementia. *Sundowning. *Wandering. Autism spectrum. *Autism. *Asperger syndrome ... Neurologic diseases such as multiple sclerosis, complex partial seizures, strokes, brain tumors, Wilson's disease, traumatic ... German psychiatrist Emil Kraepelin first distinguished between manic-depressive illness and "dementia praecox" (now known as ... A Complex Link". The Journal of Nervous and Mental Disease (Review). 205 (10): 743-756. doi:10.1097/NMD.0000000000000720. PMID ...
AIDS dementia complex. *Frontotemporal dementia. *Sundowning. *Wandering. Autism spectrum. *Autism. *Asperger syndrome ... Kitchener, Betty; Jorm, Anthony (2002). Mental Health First Aid Manual (1st ed.). Canberra: Center for Mental Health Research, ... People who were temporally hospitalized were also provided aid and care and a pre-release program was created to enable people ... The NIMH is researching only suicide and HIV/AIDS prevention, but the National Prevention Strategy could lead to it focusing ...
AIDS dementia complex. *Frontotemporal dementia. *Sundowning. *Wandering. Autism spectrum. *Autism. *Asperger syndrome ... Dementia With Lewy Bodies and Parkinson Disease Dementia". Continuum (Minneap Minn) (Review). 22 (2 Dementia): 435-63. doi: ... dementia with Lewy bodies, and other dementia. It presents often in individuals with a neurodegenerative disease, ... It is generally agreed that the Capgras delusion has a complex and organic basis[definition needed], and can ...
Dementia. *AIDS dementia complex. *Alzheimer's disease. *Creutzfeldt-Jakob disease. *Frontotemporal dementia. *Huntington's ... Some autistic people have advocated a shift in perception of autism spectrum disorders as complex syndromes rather than ... and complex whole-body movements. These are typically repeated in longer bursts and look more voluntary or ritualistic than ...
Dementia. *AIDS dementia complex. *Alzheimer's disease. *Creutzfeldt-Jakob disease. *Frontotemporal dementia. *Huntington's ... 18 (3): 263-8. doi:10.1002/1098-108X(199511)18:3,263::AID-EAT2260180308,3.0.CO;2-O. PMID 8556022.. ... Everyone differs from another, and taking such a complex behavior like bulimia and applying the same one theory to everyone ... doi:10.1002/(SICI)1098-108X(199805)23:4,371::AID-EAT4,3.0.CO;2-F. PMID 9561427.. ...
Dementia. *AIDS dementia complex. *Alzheimer's disease. *Creutzfeldt-Jakob disease. *Frontotemporal dementia. *Huntington's ... paranoia and paraphrenia are debated entities that were detached from dementia praecox by Kraepelin, who explained paranoia as ... such as depression and dementia, but they are more prevalent in three mental disorders: paranoid schizophrenia, delusional ...
"Superheroes for a complex world". The Sydney Morning Herald. Retrieved 5 August 2011 ... Semantic dementia. *Logopenic progressive aphasia. *Speech disturbances *Speech disorder. *Developmental verbal dyspraxia/ ... First aid. *Nose disorders. *Symptoms and signs: Respiratory system. Hidden categories: *CS1 maint: Extra text: authors list ...
Richard Ostfeld (2012). Lyme Disease: The Ecology of a Complex System. New York: Oxford University Press. ISBN 978-0199928477. ... The spread of B. burgdorferi is aided by the attachment of the host protease plasmin to the surface of the spirochete. ... Waniek C, Prohovnik I, Kaufman MA, Dwork AJ (1995). "Rapidly progressive frontal-type dementia associated with Lyme disease". ... Neuroimaging is controversial in whether it provides specific patterns unique to neuroborreliosis, but may aid in differential ...
DementiaEdit. Music therapy has been proven to be of beneficial use to older adults all over the world. Dr. Hanne Mette Ridder ... The singing aided with memory, as these adults improved memorization skills in by taking out specific words in the chorus of a ... He understood that medicine alone could not meet the complex needs of developmentally disabled children. Hellbrügge consulted ... Aldridge, David ( 2000). Music Therapy in Dementia Care, London: Jessica Kingsley Publishers. ISBN 1853027766 ...
Complex IV Deficiency. MT-TI mutations have been associated with complex IV deficiency of the mitochondrial respiratory ... Common symptoms include, myoclonus, myopathy, spasticity, epilepsy, peripheral neuropathy, dementia, ataxia, atrophy, and more. ... doi:10.1002/(SICI)1098-1004(1996)8:3,216::AID-HUMU4,3.0.CO;2-7. PMID 8889580.. ...
Index of HIV/AIDS-related articles
AIDS - AIDS Arms - AIDS dementia complex (ADC) - AIDS Drug Assistance Programs (ADAP) - AIDS education and training centers ( ... AIDS Vaccine 200 - AIDS Vaccine Advocacy Coalition - AIDS wasting syndrome - AIDS-related cancer - AIDS-related complex (ARC ... AETC) - AIDS orphan - AIDS research advisory committee (ARAC) - AIDS service organization (ASO) - The AIDS Show - ... This is a list of AIDS-related topics, many of which were originally taken from the public domain U.S. Department of Health ...
ICD-10 Chapter V: Mental and behavioural disorders
AIDS dementia complex. *Frontotemporal dementia. *Sundowning. *Wandering. Autism spectrum. *Autism. *Asperger syndrome ... F02) Dementia in other diseases classified elsewhere *(F02.0) Dementia in Pick's disease ...
Doty, Richard L.; Bromley, Steven M.; Stern, Matthew B. (March 1995). "Olfactory Testing as an Aid in the Diagnosis of ... "Projections from the Amygdaloid Complex and Adjacent Olfactory Structures to the Entorhinal Cortex and to the Subiculum in the ... Other neurodegenerative diseases that affect olfactory dysfunction include Huntington's disease, multi-infarct dementia, ... These cells also note differences between highly similar odors and use that data to aid in later recognition. The cells are ...
Dementia. Family dynamics. In the dysfunctional family the child learns to become attuned to the parent's needs and ... 47 (5): 720-9. doi:10.1002/1097-4679(199109)47:5,720::aid-jclp2270470515,3.0.co;2-5. PMID 1939721.. ... God complex. *History of narcissism. *Messiah complex. *Micromanagement. *Narcissism of small differences ...
A study on London taxi drivers, asked drivers to recall complex routes around the city as well as famous landmarks for which ... However, as one would expect, the knowledge that participants gleaned from the first town did not transfer, or aid them, in ... Exclusion of dementia. (TD) was assessed clinically in all participants. Neurological and neuropsychological evaluations were ... This temporary store enables one to complete or work on complex tasks while being able to keep information in mind. For ...
Amyotrophic lateral sclerosis
In 1956 the variant of ALS endemic to Guam was named "amyotrophic lateral sclerosis/parkinsonism dementia complex" (ALS/PDC), ... doi:10.1002/(SICI)1097-4598(200003)23:3,336::AID-MUS4,3.0.CO;2-L. PMID 10679709.. ... With the discovery that TDP-43, FUS, and C9orf72 can cause ALS as well as related forms of frontotemporal dementia (FTD/ALS)[ ... ALS and frontotemporal dementia (FTD) are now considered to be part of a common disease spectrum (FTD-ALS) because of genetic, ...
Morales, Paula; Hurst, Dow P.; Reggio, Patricia H. (2017). "Molecular Targets of the Phytocannabinoids: A Complex Picture". In ... has been approved by the FDA as an appetite stimulant for people with AIDS and an antiemetic for people receiving chemotherapy ... "Cannabinoids for the treatment of dementia". Cochrane Database of Systematic Reviews (2): CD007204. doi:10.1002/14651858. ... Kinghorn, A. Douglas; Falk, Heinz; Gibbons, Simon; Kobayashi, Jun'ichi (eds.). Phytocannabinoids: Unraveling the Complex ...
Beta-amiloide, a enciclopedia libre
doi:10.1002/(SICI)1096-8628(19980207)81:1,49::AID-AJMG10,3.0.CO;2-W.. ... Roses AD (February 1998). "Alzheimer diseases: a model of gene mutations and susceptibility polymorphisms for complex ... "Genetic dissection of Alzheimer's disease and related dementias: amyloid and its relationship to tau". Nat. Neurosci. 1 (5): ... "Amyloid β-Protein Stimulates Trafficking of Cholesterol and Caveolin-1 from the Plasma Membrane to the Golgi Complex in Mouse ...
Progressive supranuclear palsy
This may include being taught to use mobility aids. Due to their tendency to fall backwards, the use of a walker, ... Some consider PSP, corticobasal degeneration, and frontotemporal dementia to be variations of the same disease. Others ... Especially, mitochondrial complex I inhibitors (such as acetogenins, quinolines and rotenoids) are implicated in PSP-like brain ... Later symptoms and signs are dementia (typically including loss of inhibition and ability to organize information), slurring of ...
Of the 26.7 million people over age 50 with a hearing impairment, only one in seven uses a hearing aid. In the 70-79 age ... It takes more time to learn the same amount of new information. Dementia is a general term for memory loss and other ... "complex issues," distinct but "causally interconnected," that often include "comorbid diseases", progressive weakness, ... There is home care in which a family member, volunteer, or trained professional will aid the person in need and help with daily ...
China's large and complex EHR Standard was constructed for all medical domains. However, the specific and time-frequent ... "Automated Handwashing Assistance For Persons With Dementia Using Video and a Partially Observable Markov Decision Process". ... Health informatics law deals with evolving and sometimes complex legal principles as they apply to information technology in ... Integrated data repositories are complex systems developed to solve a variety of problems ranging from identity management, ...
Dementia pugilistica, or "punch-drunk syndrome", caused by repetitive head injuries, for example in boxing or other contact ... Lesions to the fusiform gyrus often result in prosopagnosia, the inability to distinguish faces and other complex objects from ... There are several imaging techniques that can aid in diagnosing and assessing the extent of brain damage, such as computed ... an inability to recognize complex objects, smells, or shapes, or amorphosynthesis, a loss of perception on the opposite side of ...
Dance and health
It was shown that Wu Tao dance helped to reduce symptoms of agitation in people with dementia. The complex mental ... RICE (Rest, Ice, Compression, Elevation) is generally regarded as a good first aid therapy for most dance injuries before the ... In addition to improving symptoms of dementia and preventing dementia, frequent dancing can even lead to increased cognitive ... "Exploring dance as a therapy for symptoms and social interaction in a dementia care unit". nursingtimes.net. 30 July 2009.. ...
AIDS dementia complex. *Frontotemporal dementia. *Sundowning. *Wandering. Autism spectrum. *Autism. *Asperger syndrome ... Dementia With Lewy Bodies and Parkinson Disease Dementia". Continuum (Minneap Minn) (Review). 22 (2 Dementia): 435-63. doi: ... Aarsland D, Londos E, Ballard C (April 2009) [28 January 2009]. "Parkinson's disease dementia and dementia with Lewy bodies: ... The prevalence of dementia increases with age and, to a lesser degree, duration of the disease. Dementia is associated with ...
創傷後壓力症候群 - 維基百科，自由的
愛滋病痴呆症候群（英語：AIDS dementia complex） ...
Neurofilament light polypeptide
TSC1-TSC2 complex. • axon. • neuron projection. • intermediate filament. • axon cytoplasm. • neuromuscular junction. • Schaffer ... 49 (2): 245-9. doi:10.1002/1531-8249(20010201)49:2,245::AID-ANA45,3.0.CO;2-A. PMID 11220745.. ... neurodegenerative dementia, stroke, traumatic brain injury, amyotrophic lateral sclerosis and Parkinson disease.. ...
Protein nanopore sequencing utilizes membrane protein complexes such as α-hemolysin, MspA (Mycobacterium smegmatis Porin A) or ... doctors screening an ill baby for genetic variants chose not to inform the parents of an unrelated variant linked to dementia ... Advancements in sequencing were aided by the concurrent development of recombinant DNA technology, allowing DNA samples to be ... MPSS was a bead-based method that used a complex approach of adapter ligation followed by adapter decoding, reading the ...
Some web servers provide graphical aids like maps, to aid learning during play. These graphical aids may ... 2003), "Leisure Activities and the Risk of Dementia in the Elderly", New England Journal of Medicine, 348 (25): 2508-16, doi: ... It has been claimed that Go is the most complex game in the world due to its vast number of variations in individual games.[132 ... Despite its relatively simple rules, Go is extremely complex. Compared to chess, Go has both a larger board with more scope for ...
List of neurological conditions and disorders
Complex regional pain syndrome. *Compression neuropathy. *Congenital distal spinal muscular atrophy. *Congenital facial ... Lewy body dementia. *Lissencephaly. *Locked-in syndrome. *Lou Gehrig's disease - see Amyotrophic lateral sclerosis ... AIDS - neurological manifestations. *Akinetopsia. *Alcoholism. *Alien hand syndrome. *Allan-Herndon-Dudley syndrome ...
HIV Encephalopathy and AIDS Dementia Complex: Overview, Pathophysiology, Epidemiology
The term AIDS dementia complex was introduced by Navia and colleagues in 1986. ... HIV-1 encephalopathy and AIDS dementia complex. CT scan of the brain of a patient with AIDS dementia complex (ADC) shows ... HIV-1 encephalopathy and AIDS dementia complex. CT scan of the brain of a patient with AIDS dementia complex (ADC) shows ... encoded search term (HIV Encephalopathy and AIDS Dementia Complex) and HIV Encephalopathy and AIDS Dementia Complex What to ...
AIDS-dementia complex - definition of AIDS-dementia complex by The Free Dictionary
AIDS-dementia complex synonyms, AIDS-dementia complex pronunciation, AIDS-dementia complex translation, English dictionary ... definition of AIDS-dementia complex. abbr. 1. aide-de-camp 2. Aid to Dependent Children 3. Air Defense Command 4. analog-to- ... redirected from AIDS-dementia complex). Also found in: Thesaurus, Medical, Encyclopedia.. Related to AIDS-dementia complex: ... AIDS-dementia complex - definition of AIDS-dementia complex by The Free Dictionary https://www.thefreedictionary.com/AIDS- ...
AIDS dementia complex
F02.4 ICD-9 042 AIDS dementia complex (ADC; also known as HIV ... AIDS dementia complex AIDS dementia complex (ADC)Classification ... AIDS origin · AIDS pandemic · AIDS Museum · Timeline of AIDS · Oral polio vaccine AIDS hypothesis · Reappraisal of HIV-AIDS ... AIDS dementia complex (ADC; also known as HIV dementia, HIV encephalopathy and HIV-associated dementia) is a common ... HIV (AIDS, AIDS dementia complex) - Genital warts - Adult T-cell leukemia. Viral gastroenteritis. Rotavirus - Norovirus - ...
Memantine for AIDS dementia complex: open-label report of ACTG 301. - PubMed - NCBI
Memantine for AIDS dementia complex: open-label report of ACTG 301.. Zhao Y1, Navia BA, Marra CM, Singer EJ, Chang L, Berger J ... Ellis RJ, Kolson DL, Simpson D, Miller EN, Lipton SA, Evans SR, Schifitto G; Adult Aids Clinical Trial Group (ACTG) 301 Team. ... AIDS Dementia Complex - Genetic Alliance. *AIDS-HIV - Genetic Alliance. Miscellaneous. *MEMANTINE - Hazardous Substances Data ...
Declining incidence of AIDS dementia complex after introduction of zidovudine treatment. | The BMJ
Diagnosis of AIDS dementia complex and presence of HIV I p24 antigen in cerebrospinal fluid. RESULTS--The AIDS dementia complex ... two with the AIDS dementia complex) taking zidovudine were positive. CONCLUSIONS--The incidence of AIDS dementia complex in ... Dementia was diagnosed before definition of the AIDS dementia complex (1986) according to DSM-III criteria and there was good ... Thirty eight of 107 patients with AIDS (36%) not taking zidovudine developed the AIDS dementia complex compared with two of the ...
Understanding AIDS Dementia Complex
... is a neurological disorder caused by HIV which has been classified as an AIDS-defining condition. ... AIDS dementia complex (a.k.a. HIV encephalopathy) ... AIDS Dementia Complex Impairment varies but still common in ... AIDS dementia complex (ADC), also known as HIV encephalopathy, is a neurological disorder directly caused by HIV. It is a ... Causes of AIDS Dementia ADC usually occurs in advanced disease when the patients CD4 count is below 200 cells/μl and is ...
AIDS Dementia Complex: Related Resources
The assessment of cognitive function in advanced HIV-1 infection and AIDS dementia complex using a new computerised cognitive ... Neurologic AIDS Research Consortium. (NARC) Supported by the NIH to design and implement studies of HIV-associated neurologic ... HIV-Associated Dementia and Minor Cognitive Motor Disorder Section: Clinical Manual for Management of the HIV-Infected Adult. ... AHP) Premier HIV/AIDS, LGBTQ, and mental health agency, part of the University of California San Francisco. ...
Proton MRS and neuropsychological correlates in AIDS dementia complex: evidence of subcortical specificity. - PubMed - NCBI
Proton MRS and neuropsychological correlates in AIDS dementia complex: evidence of subcortical specificity.. Paul RH1, ... authors performed magnetic resonance spectroscopic and neuropsychological evaluations on 61 patients with AIDS dementia complex ... AIDS Dementia Complex - Genetic Alliance. *AIDS-HIV - Genetic Alliance. Miscellaneous. *(L)-ASPARTIC ACID - Hazardous ...
AIDS Dementia Complex (ADC) definition | Psychology Glossary | alleydog.com
Psychology definition for AIDS Dementia Complex (ADC) in normal everyday language, edited by psychologists, professors and ... AIDS Dementia Complex (ADC). AIDS dementia complex (ADC) is a common complication of the central nervous system that can occur ... ADC is characterized by mental, motor, and behavioral symptoms (which is what the term complex signifies). The most ... noticeable symptom is dementia which is an acquired cognitive decline. In later stages of HIV severe suppression of the immune ...
NFkappaB activation, TNF-alpha expression, and apoptosis in the AIDS-Dementia-Complex
A Study to Evaluate the Use of Stavudine (d4T) to Treat AIDS Dementia Complex - Full Text View - ClinicalTrials.gov
Dementia. AIDS Dementia Complex. Lentivirus Infections. Retroviridae Infections. RNA Virus Infections. Virus Diseases. Sexually ... A Study to Evaluate the Use of Stavudine (d4T) to Treat AIDS Dementia Complex. The safety and scientific validity of this study ... A Pilot Open Label, Multicenter Study to Evaluate the Role of Stavudine (d4T) in the Treatment of AIDS Dementia Complex. ... can improve symptoms of AIDS Dementia Complex (ADC, problems involving the brain or spinal cord) in HIV-positive patients. ...
What does aids dementia complex mean?
Meaning of aids dementia complex. What does aids dementia complex mean? Information and translations of aids dementia complex ... Definition of aids dementia complex in the Definitions.net dictionary. ... AIDS dementia complex. AIDS dementia complex is a common neurological disorder associated with HIV infection and AIDS. It is a ... Definitions for aids dementia complex. Here are all the possible meanings and translations of the word aids dementia complex.. ...
AIDS Dementia Complex Symptoms, Diagnosis, Treatments and Causes - RightDiagnosis.com
AIDS Dementia Complex information including symptoms, diagnosis, misdiagnosis, treatment, causes, patient stories, videos, ... Contents for AIDS Dementia Complex: *AIDS Dementia Complex *What is AIDS Dementia Complex? *Prevalence and Incidence of AIDS ... Videos related to AIDS Dementia Complex *Types of AIDS Dementia Complex *Causes of AIDS Dementia Complex *Symptoms of AIDS ... AIDS Dementia Complex: Deaths. Read more about Deaths and AIDS Dementia Complex. Causes of AIDS Dementia Complex. Read more ...
Search of: HIV/AIDS AND neuroAIDS OR HIV/AIDS neuropathy OR polyneuropathy OR AIDS dementia complex OR AIDS neuropathy OR HIV...
HIV/AIDS AND neuroAIDS OR HIV/AIDS neuropathy OR polyneuropathy OR AIDS dementia complex OR AIDS neuropathy OR HIV neuropathy ... HIV/AIDS AND neuroAIDS OR HIV/AIDS neuropathy OR polyneuropathy OR AIDS dementia complex OR AIDS neuropathy OR HIV neuropathy ... 23 Studies found for: HIV/AIDS AND neuroAIDS OR HIV/AIDS neuropathy OR polyneuropathy OR AIDS dementia complex OR AIDS ... Chemotherapy and HAART to Treat AIDS-related Primary Brain Lymphoma. *Lymphoma-AIDS-Related ...
ERIC - The Brain in AIDS: Central Nervous System HIV-1 Infection and AIDS Dementia Complex., Science, 1988
AIDS) dementia complex. Explains the syndromes development of abnormalities in cognition, motor performance, and behavior. (TW ... The Brain in AIDS: Central Nervous System HIV-1 Infection and AIDS Dementia Complex. ... AIDS) dementia complex. Explains the syndromes development of abnormalities in cognition, motor performance, and behavior. (TW ...
Clinical Trial on AIDS Dementia Complex: Stavudine
... can improve symptoms of AIDS Dementia Complex (ADC, problems involving the brain or spinal cord) in HIV-positive patients. ... in the Treatment of AIDS Dementia Complex A Study to Evaluate the Use of Stavudine (d4T) to Treat AIDS Dementia Complex ... can improve symptoms of AIDS Dementia Complex (ADC, problems involving the brain or spinal cord) in HIV-positive patients. ... AIDS ReSEARCH Alliance , West Hollywood, California, 90069, United States Mount Sinai Hosp , New York, New York, 100296574, ...
AIDS dementia complex synonyms, AIDS dementia complex antonyms - FreeThesaurus.com
Antonyms for AIDS dementia complex. 57 synonyms for complex: compound, compounded, multiple, composite, manifold, heterogeneous ... Synonyms for AIDS dementia complex in Free Thesaurus. ... AIDS dementia complex synonyms, AIDS dementia complex antonyms ... Project Informs AIDS dementia complex (ADC) (HIV/AIDS treatment information).. CT assessment of CNS complications of AIDS. ( ... complex. (redirected from AIDS dementia complex). Also found in: Dictionary, Medical, Legal, Acronyms, Encyclopedia, Wikipedia ...
AIDS Dementia Complex | Parthenon Pavilion
Learn more about AIDS Dementia Complex at TriStar Centennial Parthenon Pavilion DefinitionCausesRisk ... AIDS dementia complex (ADC) can occur in people with AIDS. ADC results in changes in multiple neurologic areas: *Cognition-the ... An overview of AIDS dementia complex. Am J Alzheimers Dis Other Demen. 2001;16(4):225-229. ... AIDS dementia complex. University of California at San Francisco website. Available at: http://hivinsite.ucsf.edu/InSite?page= ...
AIDS Dementia Complex (ADC)| Interactive Health
AIDs Dementia Complex is a condition of memory loss and other neurological functions that are affected with HIV spreads to the ... AIDS Dementia Complex. AIDs Dementia Complex is a condition of memory loss and other neurological functions that are affected ... AIDs Dementia Complex can also be known as HIV encephalopathy and HIV dementia ... Dementia. - Difficulty with concentration. - Fatigue. - Confusion. - Mental change. Staging. Stage 0 - Normal mental status and ...
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December 1994 - Volume 7 - Issue - Contributor Index : JAIDS Journal of Acquired Immune Deficiency Syndromes
Health Information | Griffin Health - Derby, Connecticut | Health Library
AIDS Dementia Complex. (ADC; AIDS Encephalopathy; AIDS-related Dementia; ARD; HIV-associated Dementia Complex; HIV ... AIDS dementia complex (ADC) is a loss in mental skills in people with late-stage AIDS. It can affect thinking, reasoning, ... www.hopkinsmedicine.org/health/conditions-and-diseases/hiv-and-aids/hiv-and-dementia. Accessed October 16, 2019. ... AIDS cannot be cured. Symptoms may be managed with: Medicine Antiretroviral drugs are used to lower the amount of the virus in ...
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AIDS-dementia complex. See: AIDS-dementia complex. alcoholic dementia. A form of toxic dementia in which there is loss of ... Heller dementia. Regressive autism.. HIV-associated dementia See: AIDS-dementia complex. dementia with Lewy bodies. A common ... syphilitic dementia. Dementia caused by tertiary syphilis. toxic dementia. Dementia caused by exposure to neurotoxins such as ... postfebrile dementia. Dementia following a severe febrile illness. presenile dementia. Dementia beginning in middle age, ...
AIDS Dementia Complex | Genetic and Rare Diseases Information Center (GARD) - an NCATS Program
Young onset dementia | Postgraduate Medical Journal
AIDS dementia complex. AIDS dementia complex should not be overlooked as a cause of YOD. It generally presents as a subcortical ... VASCULAR DEMENTIA. Vascular dementia is a common cause of YOD.2 Patients developing young onset vascular dementia may lack ... YOD, young onset dementia. Dementia in younger people (young onset dementia, YOD) is increasingly recognised as an important ... Lewy body dementia. Lewy body dementia appears to be relatively uncommon in younger populations; the clinical presentation is ...
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AIDs can actually increase a persons risk for developing dementia later in life, due to the impact on the central nervous ... AIDS Dementia Complex (ADC). With the introduction of combination antiretroviral therapy, ADC became more complex among ... and are now commonly referred to as AIDS dementia complex (ADC). The complex part of the name references the impact of the ... The Evolution of AIDS Dementia Complex. Although the symptoms called ADC were observed early among late-stage HIV patients, ...
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Make research projects and school reports about dementia easy with credible articles from our FREE, online encyclopedia and ... suggests that AIDS dementia complex (also known as HIV-associated dementia) may affect up to 60 percent of patients with AIDS ... brew, b. (1999). "aids dementia complex." neurologicclinics 17(4):861-881.. brown, d. f. (1999). "lewy body dementia." annals ... and the AIDS complex are also significant causes of dementia. Some dementias are due to reversible causes (e.g., depression, ...
EncephalopathySymptomsAlzheimer'sInfectionAcquired immunodeVascularEncephalitisImpairmentParkinson'sBrainCerebrospinal fluidSevereZidovudineComplications2002DisorderDiagnosisDeclineOccur1986PatientsOnsetDisordersType of dementiaCases of dementiaLewyPathogenesisPeripheral neuropathyStagesPrimary dementiaUniversity of CalifoProgressiveNeurologicLymphomaGeneticBehavioralInfectionsVitamin B 12 deficMentalReversibleDefinitionTreatmentPatientAdultsCancersProteinDiseasesCommonClinical
- [ 1 , 2 ] Human immunodeficiency virus (HIV) enters the central nervous system (CNS) early in the course of the infection and causes several important CNS conditions over the course of the disease, such as HIV encephalopathy and AIDS dementia complex. (medscape.com)
- HIV-associated progressive encephalopathy (HPE) is a syndrome complex with cognitive, motor, and behavioral features seen in children. (medscape.com)
- It can range from asymptomatic neurocognitive impairment (ANI) to minor neurocognitive disorder (MND) to more severe HIV-associated dementia (HAD) (also called AIDS dementia complex [ADC] or HIV encephalopathy). (medscape.com)
- also known as HIV dementia , HIV encephalopathy and HIV-associated dementia ) is a common neurological disorder associated with HIV infection and AIDS . (bionity.com)
- AIDS dementia complex (ADC), also known as HIV encephalopathy, is a neurological disorder directly caused by HIV . (verywellhealth.com)
- Pathologic processes, such as HIV encephalopathy and AIDS dementia complex (ADC), should be considered when atrophy is identified. (freethesaurus.com)
- Pathologic features of AIDS encephalopathy in children: Evidence for LAV/HTLV-II1 infection of brain. (springer.com)
- Even though the virus can enter the brain fairly soon after infection, HIV encephalopathy tends to occur in advanced HIV, making it an AIDS -defining illness. (healthline.com)
- AIDS dementia complex (ADC) , or HIV-associated encephalopathy, occurs primarily in persons with more advanced HIV infection. (thebody.com)
- That damage, Peterson observed, inflicts on its late-stage HIV-infected victim an encephalopathy called AIDS dementia complex(ADC). (bioworld.com)
- PATIENTS--196 Patients with AIDS and neurological symptoms examined from 1982 to 1988. (bmj.com)
- INTERVENTIONS--Zidovudine treatment, which was introduced to The Netherlands on 1 May 1987 for patients with severe symptoms of HIV infection (Centers for Disease Control groups IVA, B, C, and D). MAIN OUTCOME MEASURES--Diagnosis of AIDS dementia complex and presence of HIV I p24 antigen in cerebrospinal fluid. (bmj.com)
- ADC is characterized by mental, motor, and behavioral symptoms (which is what the term 'complex' signifies). (alleydog.com)
- The purpose of this study is to see if adding stavudine (d4T) to anti-HIV drug regimens (with or without zidovudine, ZDV) can improve symptoms of AIDS Dementia Complex (ADC, problems involving the brain or spinal cord) in HIV-positive patients. (clinicaltrials.gov)
- More detailed information about the symptoms , causes , and treatments of AIDS Dementia Complex is available below. (rightdiagnosis.com)
- Although the symptoms called ADC were observed early among late-stage HIV patients, doctors and researchers have watched the evolution of this form of dementia. (dementia.org)
- A recent article compiled a list of a few of the names for the symptoms of cognitive decline in HIV/AIDS patients. (dementia.org)
- With a complication to an already complex illness, treatment of ADC must be multifaceted if it is to be successful in reducing symptoms and distress. (dementia.org)
- What are some causes of neurological symptoms in AIDS patients? (brainscape.com)
- Patients present with protean clinical pictures that vary from complete absence of symptoms and signals to focal disorders or severe dementia. (scielo.br)
- Since the recogniton of neurologic disorders in AIDS patients, it was observed that systemic derangements induce worsening of neurologic symptoms, mostly the demential ones. (scielo.br)
- Symptoms range from minor cognitive difficulty to severe dementia. (frontiersin.org)
- Neurological symptoms may be mild in the early stages of AIDS, but may become severe in the final stages. (nih.gov)
- Symptoms of dementia can be classified as either reversible or irreversible depending upon the etiology of the disease. (statemaster.com)
- Still others have more severe and progressive symptoms, with dementia being the most advanced form. (poz.com)
- It is not yet known whether people with mild symptoms are at greater risk of progressing to severe dementia. (poz.com)
- AIDS-related disorders of the nervous system may be caused directly by the HIV virus, by certain cancers and opportunistic infections (illnesses caused by bacteria, fungi, and other viruses that would not otherwise affect people with healthy immune systems), or by toxic effects of the drugs used to treat symptoms. (thebody.com)
- Symptoms of CMV encephalitis include weakness in the arms and legs, problems with hearing and balance, altered mental states, dementia , peripheral neuropathy , coma, and retinal disease that may lead to blindness. (thebody.com)
- Exclusion Criteria Co-existing Condition: Patients with the following conditions or symptoms are excluded: - An active AIDS defining opportunistic infection or other active intercurrent illnesses if their ongoing treatment requires the use of excluded medications (see Exclusion - Concurrent Medications). (clinicalconnection.com)
- While the degenerative dementias characteristically affect older patients, they are also an important cause of YOD: indeed, Alzheimer's disease is the commonest single cause of YOD with an estimated 3000 cases in the United Kingdom, followed by vascular dementia and the frontotemporal lobar degenerations (table 1). (bmj.com)
- The Family Caregiver Alliance also suggests that ADC be seen as a dementia similar to other well-known dementias, like Alzheimer's disease. (dementia.org)
- They include Alzheimer's disease (AD), frontal lobe dementia (FLD), and Pick's disease. (encyclopedia.com)
- They are associated with Alzheimer's and Parkinson's disease, but researchers do not yet know whether dementia with Lewy bodies is a distinct type of dementia or a variation of Alzheimer's or Parkinson's disease. (encyclopedia.com)
- Dr. Kao's clinical expertise includes the diagnosis and treatment of Alzheimer's disease , vascular dementia and frontotemporal lobar degeneration . (ucsf.edu)
- citation needed] In the 2013 biographical film Dallas Buyers Club, protagonist Ron Woodroof (Matthew McConaughey) promotes the use of injected peptide T as a treatment for HIV/AIDS and Alzheimer's Disease and sues the FDA over their efforts to limit his ability to use peptide T, as it was an unapproved medicine. (wikipedia.org)
- No evidence of another, pre-existing aetiology that could explain the dementia (e.g. another CNS infection, CNS neoplasm, cerebrovascular disease, pre-existing neurological disease, severe substance abuse compatible with CNS disorder. (bionity.com)
- AIDS Dementia Complex (ADC) is not a true opportunistic infection. (bionity.com)
- Unlike most AIDS-defining conditions, ADC is not an opportunistic infection insofar as the condition is caused by HIV itself. (verywellhealth.com)
- The assessment of cognitive function in advanced HIV-1 infection and AIDS dementia complex using a new computerised cognitive test battery. (ucsf.edu)
- AIDS dementia complex (ADC) is a common complication of the central nervous system that can occur during the later stages of HIV infection. (alleydog.com)
- Have peripheral neuropathy or a newly diagnosed AIDS-defining infection that requires treatment at the time of study enrollment. (clinicaltrials.gov)
- The Brain in AIDS: Central Nervous System HIV-1 Infection and AIDS Dementia Complex. (ed.gov)
- Discusses the complicated infection of human immunodeficiency virus type 1 (HIV-1) in its late stages of the acquired immune deficiency syndrome (AIDS) dementia complex. (ed.gov)
- This disorder is associated with a worsening or more severe cases of HIV and AIDS and the greater the spread of the infection, often the more pronounced the dementia. (iahealth.net)
- Even so, clinical evidence of HIV-mediated neurologic dysfunction (ie, dementia, gait impairment) typically does not occur until late in the course of infection when there is high viral load and evidence of immunosuppression manifested by a low CD4 lymphocyte count. (medscape.com)
- Dal Canto, MC 1997, ' Mechanisms of HIV infection of the central nervous system and pathogenesis of AIDS-dementia complex ', Neuroimaging Clinics of North America , vol. 7, no. 2, pp. 231-241. (northwestern.edu)
- The macrophage is well established as a target of HIV and simian immunodeficiency virus (SIV) infection and a major contributor to the neuropathogenesis of AIDS. (rupress.org)
- We further demonstrate that although productive viral infection of the CNS occurs early, thereafter it is not easily detectable until terminal AIDS. (rupress.org)
- The book AIDS Pathogenesis provides the reader with a complete overview of the clinical course of HIV-1 infection. (springer.com)
- For patient education information, see the Immune System Center , Dementia Center , and Sexually Transmitted Diseases Center , as well as Dementia Due to HIV Infection and HIV/AIDS . (medscape.com)
- Have a diagnosis of AIDS or advanced AIDS related complex (ARC), or per 8/09/90 amendment, asymptomatic HIV infection with CD4 count = or (knowcancer.com)
- For patients with 2 months or less experience with AZT, PCP infection will be the single and only AIDS-defining infection and must have been within 120 days of study entry. (knowcancer.com)
- The more the infection spreads within the brain, the worse the dementia becomes. (healthline.com)
- Acquired immune deficiency syndrome (AIDS) is the result of an infection with the human immunodeficiency virus (HIV). (nih.gov)
- People with AIDS are also likely to get a herpes virus infection, like shingles, and inflammation in the brain and spinal cord. (hopkinsmedicine.org)
- en] HIV-1 infection of the brain and PAF neurotoxicity are implicated in AIDS dementia complex. (ac.be)
- AIDS (acquired immune deficiency syndrome) is a condition that occurs in the most advanced stages of human immunodeficiency virus (HIV) infection. (thebody.com)
- It may take many years for AIDS to develop following the initial HIV infection. (thebody.com)
- Importantly, it occurs in most, but not all, cases of dementia related to HIV-1 infection. (asmscience.org)
- It was usually observed in the late stages of acquired immunodeficiency syndrome (AIDS), when CD4 + lymphocyte counts fall below 200 cells/mL, and was seen in up to 50% of patients prior to their deaths. (medscape.com)
- AIDS = acquired immunodeficiency syndrome. (medscape.com)
- This finally results in the host's incapacity to deal with opportunistic infections and the immune surveillance of tumors, a clinical status known as the Acquired Immunodeficiency Syndrome (AIDS). (springer.com)
- Acquired immunodeficiency syndrome (AIDS) is an illness that weakens the body's immune system. (medicalcityhospital.com)
- Sometimes called vascular dementia , this type is caused by blood clots in the small blood vessels of the brain. (encyclopedia.com)
- F00-F99 - Mental and behavioural disorders (F00-F09) Organic, including symptomatic, mental disorders (F00) Dementia in Alzheimers disease (F01) Vascular dementia (F011) Multi-infarct dementia (F02) Dementia in other diseases classified elsewhere (F020) Dementia in Picks disease (F021) Dementia in Creutzfeldt-Jakob disease (F022) Dementia in Huntingtons. (statemaster.com)
- I disagree with the statement made on page 551 that chorea is pathognomonic of toxoplasmosis encephalitis in patients with AIDS. (bmj.com)
- Using a simian immunodeficiency virus (SIV)/macaque model for HIV encephalitis and AIDS, we evaluated whether infected cells persist in brain despite ART. (asm.org)
- Dementia only exists when neurocognitive impairment in the patient is severe enough to interfere markedly with day-to-day function. (bionity.com)
- While the more severe manifestations of ADC have decreased greatly in numbers since the advent of combination antiretroviral therapy (ART) , mild neurocognitive impairment is still seen in about 30% of those with asymptomatic HIV and 50% of those with AIDS. (verywellhealth.com)
- Dementia is very rare before the age of 40: in young adults and adolescents, genetic and metabolic disorders predominate and many present as a "dementia-plus" syndrome, where cognitive impairment occurs in the setting of more widespread neurological disturbance. (bmj.com)
- 6 Many of the dementia-plus syndromes and metabolic disorders have "subcortical" cognitive impairment that may be misinterpreted as a pseudodementia. (bmj.com)
- The Official Journal of the International AIDS Society found that in using neuropsychological tests, 15-50 percent of patients showed cognitive impairment . (dementia.org)
- HIV is neurotrophic, and most patients who have tested positive for HIV develop neuropsychiatric impairment during the course of illness, which ranges from HIV-associated mild cognitive motor disorder to HIV-associated dementia (1-5) . (ajnr.org)
- Dementia is a brain disorder characterized by a general loss of intellectual abilities involving impairment of memory, judgment, and abstract thinking as well as changes in personality. (medicalcityhospital.com)
- This report concerns four Japanese autopsy cases of Parkinson's disease (PD) mimicking senile dementia of the Alzheimer type. (biomedsearch.com)
- The amount of virus in the brain does not correlate well with the degree of dementia , suggesting that secondary mechanisms are also important in the manifestation of ADC. (bionity.com)
- A brain disorder that occurs in AIDS patients. (rightdiagnosis.com)
- AIDs Dementia Complex is a condition of memory loss and other neurological functions that are affected with HIV spreads to the brain. (iahealth.net)
- HIV/AIDS is a disease impacting the central nervous system, in which the brain is a major player. (dementia.org)
- Although dementia is not caused by aging itself - most researchers regard it as resulting from injuries, infections, brain diseases, tumors, or other disorders - it is quite common in older people. (encyclopedia.com)
- These dementias are characterized by damage to or wasting away of the brain tissue itself. (encyclopedia.com)
- FLD is dementia caused by a disorder (usually genetic) that affects the front portion of the brain, and Pick's disease is a rare type of primary dementia that is characterized by a progressive loss of social skills, language, and memory, leading to personality changes and sometimes loss of moral judgment. (encyclopedia.com)
- Dementia related to abnormalities in the structure of the brain. (encyclopedia.com)
- In our large [collection of] postmortem material of dementia and AD, we did not find any indications for fungal infections, although we did not use specific methods to detect fungal material in the brain. (alzforum.org)
- Relationship between HIV-associated dementia and viral load in cerebrospinal fluid and brain. (springer.com)
- This affects both brain volume and brain structure, causing memory and cognitive problems and eventually dementia . (healthline.com)
- Radiation therapy may be needed to treat AIDS-related cancers present in the brain or spinal cord. (nih.gov)
- Dementia (from Latin de- "apart, away" + mens ( genitive mentis ) "mind") is the progressive decline in cognitive function due to damage or disease in the brain beyond what might be expected from normal aging . (statemaster.com)
- Many factors can contribute to brain problems in people with HIV, including high viral load, low CD4 counts, AIDS-related illnesses, side effects from HIV meds, persistent inflammation, aging, and depression and other mental health issues. (poz.com)
- A FDG-PET neuro-imaging study in an individual with AIDS dementia who completed a 12-wk treatment with intranasal DAPTA, showed remission in 34 out of 35 brain regions after treatment. (wikipedia.org)
- OBJECTIVE--To assess the incidence of the AIDS dementia complex and the presence of HIV I p24 antigen in cerebrospinal fluid in relation to zidovudine treatment. (bmj.com)
- Sixteen of 61 samples of cerebrospinal fluid (26%) from patients with AIDS (10 with the AIDS dementia complex) not taking zidovudine were positive for HIV I p24 antigen, whereas none of 37 cerebrospinal fluid samples from patients with AIDS (two with the AIDS dementia complex) taking zidovudine were positive. (bmj.com)
- The effect of d4T-containing regimens is assessed for the following parameters: neurological status, survival, AIDS-defining conditions, CSF (cerebrospinal fluid) and plasma viral load, CSF and blood immunological markers, blood CD4 cell counts, and viral resistance. (clinicaltrials.gov)
- AIDS Dementia Complex (ADC), which is also referred to as HIV-associated dementia, is the most severe form of HANDs (Chow, 2013). (ipl.org)
- In many patients with AIDS, severe neurologic deficits develop that have been designated the HIV-associated cognitive-motor complex. (northwestern.edu)
- Although AIDS is primarily an immune system disorder, it also affects the nervous system and can lead to a wide range of severe neurological disorders. (thebody.com)
- Later, loss of intellectual function and musclecoordination may occur, and severe dementia, paraplegia evenconvulsions, can mark the syndrome's final stages. (bioworld.com)
- Declining incidence of AIDS dementia complex after introduction of zidovudine treatment. (bmj.com)
- Thirty eight of 107 patients with AIDS (36%) not taking zidovudine developed the AIDS dementia complex compared with two of the 89 (2%) taking the drug (p less than 0.00001). (bmj.com)
- The incidence of the AIDS dementia complex increased to 53% in the first half of 1987, after the introduction of zidovudine in May 1987, decreasing to 10% in the second half of 1987 and to 3% in 1988. (bmj.com)
- Zidovudine treatment of the AIDS dementia complex: Results of a placebo-controlled trial. (springer.com)
- Maintenance therapy for active AIDS defining opportunistic infections for patients with 9 to 47 weeks' experience with zidovudine (AZT). (knowcancer.com)
- ddC) monotherapy is safe and tolerable in the treatment of patients with AIDS or advanced AIDS related complex (ARC) who previously demonstrated intolerance to zidovudine (AZT) treatment while in Protocol N3300 (NIAID ACTG 114) or N3492 (NIAID ACTG 119). (clinicalconnection.com)
- CT assessment of CNS complications of AIDS. (freethesaurus.com)
- Neurological complications of AIDS are often underrecognized by AIDS clinicians, so patients who suspect they are having neurological complications should be sure to discuss these with their doctor. (nih.gov)
- The NINDS supports a broad spectrum of basic and clinical research studies on the neurological complications of AIDS. (nih.gov)
- HIV and AIDS both cause a number of neurological problems, also known as complications, in your nervous system. (hopkinsmedicine.org)
- In the United States, neurological complications are seen in more than 40 percent of adult patients with AIDS. (thebody.com)
- What Are Some of the Neurological Complications That Are Associated With AIDS? (thebody.com)
- About four to five million persons in the United States are affected by dementia as of 2002. (encyclopedia.com)
- Dementia is not a specific disorder or disease. (encyclopedia.com)
- The human immunodeficiency virus (HIV) infects CD4+ cells (lymphocytes, macrophages, monocytes, and microglia), whose malfunction leads to a great number of complicating situations ranging from opportunistic infections to cancers and AIDS related dementia complex, the most frequent disorder of the central nervous system (CNS) seen in these patients 1,2 . (scielo.br)
- Previous studies have indicated that p53 may be involved in the onset of neurological disorder in AIDS. (frontiersin.org)
- AIDS is primarily an immune system disorder caused by the human immunodeficiency virus (HIV), but it can also affect the nervous system. (nih.gov)
- Dementia may refer to: Dementia, the cognitive disorder. (statemaster.com)
- Dementia was diagnosed before definition of the AIDS dementia complex (1986) according to DSM-III criteria and there was good agreement between diagnosis before and after 1986. (bmj.com)
- This review presents an approach to the diagnosis, investigation, and management of patients with young onset dementia, with particular reference to common and treatable causes. (bmj.com)
- The AIDS diagnosis was based on the Center of Disease Control (CDC) / World Health Organization (WHO) classification system 2 . (scielo.br)
- The most noticeable symptom is dementia which is an acquired cognitive decline. (alleydog.com)
- A common scenario in aged care is for a patient to show mental decline to dementia . (rightdiagnosis.com)
- Whereas earlier descriptions of dementia emphasized memory loss, the last three editions of the professional's diagnostic handbook, Diagnostic and Statistical Manual of Mental Disorders (also known as the DSM ) define dementia as an overall decline in intellectual function, including difficulties with language, simple calculations, planning and judgment, and motor (muscular movement) skills as well as loss of memory. (encyclopedia.com)
- In the past two years, significant advances have been made in the treatment of HIV disease, and these advances have led to the first decline in AIDS-related mortality since the Centers for Disease Control began tracking the epidemic in the early 1980s. (thebody.com)
- Although much of this reduced mortality can be attributed to the introduction of the protease inhibitors , which became widely available in early 1996, AIDS deaths actually began to decline in some locations as early as 1993. (thebody.com)
- AIDS dementia complex (ADC) can occur in people with AIDS . (tristarparthenonpavilion.com)
- 4 Some degenerative dementias such as variant Creutzfeldt-Jakob disease typically occur in the young patient. (bmj.com)
- Dementia can occur to anyone at any age from an injury or from oxygen deprivation, although it is most commonly associated with aging. (encyclopedia.com)
- Chorea may also occur in patients with AIDS dementia complex (ADC). (bmj.com)
- Although dementia is far more common in the geriatric population, it may occur in any stage of adulthood. (statemaster.com)
- Prior to the advent of highly active antiretroviral therapy (HAART), dementia was a common source of morbidity and mortality in HIV-infected patients. (medscape.com)
- The overall psychosocial and emotional burden on the family and friends of patients with HIV dementia is tremendous, far beyond that of a cognitively intact patient with AIDS. (medscape.com)
- DESIGN--Retrospective study of a consecutive series of patients with AIDS from 1982 to 1988. (bmj.com)
- RESULTS--The AIDS dementia complex was diagnosed in 40 of the 196 (20%) patients with AIDS. (bmj.com)
- The authors performed magnetic resonance spectroscopic and neuropsychological evaluations on 61 patients with AIDS dementia complex (stages 1-3) and 39 HIV-positive neurologically asymptomatic individuals. (nih.gov)
- Patients are evaluated on a weekly basis until the dementia deterioration is confirmed to be caused by HIV-1. (clinicaltrials.gov)
- CSF protein [tau] concentrations in patients with AIDS dementia complex did not differ from those found in HIV-1-infected nondemented patients and in healthy controls. (freethesaurus.com)
- In contrast, Lewy body dementia, which accounts for 20% of cases in patients over 65 years of age, accounts for only a small proportion of YOD. (bmj.com)
- With the introduction of combination antiretroviral therapy, ADC became more complex among patients. (dementia.org)
- using scores to understand HIV dementia levels in their patients. (dementia.org)
- AIDS dementia complex (ADC) develops in only a third of HIV-infected patients who progress to AIDS. (edu.au)
- How do you prevent Toxoplasma gondii in AIDS patients? (brainscape.com)
- FA values for the splenium were significantly reduced in the patients infected with HIV and correlated with dementia severity and deficits in motor speed. (ajnr.org)
- Diffusion abnormalities were identified in the splenium of the corpus callosum in patients infected with HIV, and these alterations were associated with dementia severity and motor speed losses. (ajnr.org)
- Autopsy studies of HIV-dementia (HIV-D) patients indicate prominent injury, including increased numbers of microglia, macrophages, astrocytes, and multinucleated giant cells, in basal ganglia and deep white matter. (ajnr.org)
- In this investigation, DTI was used to derive tissue status measurements in corpus callosum (genu and splenium) and in FWM of cognitively impaired patients infected with HIV to determine the significance of injury in these regions to dementia severity and deficits in attention, memory, constructional abilities, and motor speed. (ajnr.org)
- Sixty-three AIDS patients ranked as CDC group IV had their EEG background rhythm measured, and were appointed to mutually exclusiding groups delimited by medians' values of urea (24 mg/dl) and creatinine (0.9 mg/dl) seric concentrations. (scielo.br)
- In spite of being neurologically asymptomatic, these patients already exhibit electroencephalographic (EEG) alterations, such as slow background rhythm, that become clearer during the initial phases of AIDS dementia complex. (scielo.br)
- Since its introduction, fewer than 10% of AIDS patients develop VM. (medscape.com)
- AZT is effective in reducing mortality in patients with AIDS who receive the drug after the first episode of Pneumocystis carinii pneumonia (PCP) and in patients with advanced ARC. (knowcancer.com)
- Patients whose AIDS-defining condition is Kaposi's sarcoma alone must have CD4 cell counts (knowcancer.com)
- AIDS patients may develop one or more CNS lymphomas. (thebody.com)
- Cryptococcal meningitis is seen in about 10 percent of untreated AIDS patients and in other persons whose immune systems have been severely suppressed by disease or drugs. (thebody.com)
- Herpes virus infections are often seen in AIDS patients. (thebody.com)
- It is sometimes seen as the first sign of the onset of AIDS. (bionity.com)
- The onset of primary dementia may be slow, taking months or years. (thefreedictionary.com)
- Young onset dementia is a challenging clinical problem with potentially devastating medical and social consequences. (bmj.com)
- Dementia in younger people (young onset dementia, YOD) is increasingly recognised as an important clinical and social problem, with frequently devastating consequences for both the sufferer and those who care for them. (bmj.com)
- Dementia is defined as having a persistent disruption of mental processes marked by personality changes, memory disorders, and impaired reasoning. (verywellhealth.com)
- Dementia can be caused by nearly forty different diseases and conditions, ranging from dietary deficiencies and metabolic disorders to head injuries and inherited diseases. (encyclopedia.com)
- At a right time that coincides with immunity worsening, neurologic alterations begin to show up: tremors, weakness, amyotrophy, paraparesis, paresis, and the above mentioned AIDS dementia complex characterized by motor, cognitive, and behavioral disorders 4 . (scielo.br)
- The National Institute of Neurological Disorders and Stroke (NINDS), one part of the National Institutes of Health (NIH), supports research on the neurological consequences of AIDS. (nih.gov)
- Other AIDS-related nervous system disorders may be caused by certain cancers or by illnesses that would not otherwise affect people with healthy immune systems. (nih.gov)
- People with HIV or AIDS often develop anxiety disorders. (hopkinsmedicine.org)
- Other neuro-AIDS disorders of unknown origin may be influenced by but are not caused directly by the virus. (thebody.com)
- In Goodkin K, Shapshak P, Verma A (ed), The Spectrum of Neuro-AIDS Disorders . (asmscience.org)
Type of dementia1
- This type of dementia can be life-threatening. (hopkinsmedicine.org)
Cases of dementia1
- Less than 10 percent of cases of dementia are due to causes which may presently be reversed with treatment. (statemaster.com)
- Lewy body dementia. (encyclopedia.com)
- These include the biology of the virus and the novel insights in AIDS pathogenesis. (springer.com)
- VM is often associated with AIDS dementia complex and peripheral neuropathy. (medscape.com)
- Sometimes, in the later stages of dementia, apathy gets the better of the person in the midst of bathing or dressing. (onemedic.net)
- VM occurs during the late stages of AIDS, when CD4 + lymphocyte counts are very low, often in conjunction with AIDS dementia complex, peripheral neuropathies, and opportunistic infections or malignancies of the central or peripheral nervous system (eg, cytomegalovirus, progressive multifocal leukoencephalopathy, lymphoma). (medscape.com)
- That's particularly the case if HIV progresses to AIDS, which occurs in the most advanced stages of HIV. (hopkinsmedicine.org)
- Primary dementia. (encyclopedia.com)
University of Califo1
- AHP) Premier HIV/AIDS, LGBTQ, and mental health agency, part of the University of California San Francisco. (ucsf.edu)
- Miller R, Storey J, Greco C.: Ganciclovir in the treatment of progressive AIDS-related polyradiculopathy. (springer.com)
- This report reviews the specific neurologic conditions encountered by a clinical neurologist at an HIV neurology clinic during his 15-year experience as consultant to the Tulane-Louisiana State University AIDS Clinical Trial Unit at the Medical Center of Louisiana in New Orleans. (medscape.com)
- AIDS-related cancers such as lymphoma and opportunistic infections (OI) may also affect the nervous system. (nih.gov)
- Genetic factors play a role in several types of dementia, but the importance of these factors in the development of the dementia varies considerably. (encyclopedia.com)
- Association of Cognitive and Behavioral Features Between Adults With Tuberous Sclerosis and Frontotemporal Dementia. (ucsf.edu)
- The immune systems of people with AIDS are not able to fight off certain infections and cancers. (medicalcityhospital.com)
Vitamin B 12 defic1
- Dementia may also be associated with depression, low levels of thyroid hormone, or niacin or vitamin B 12 deficiency. (encyclopedia.com)
- AIDS dementia complex (ADC) is a loss in mental skills in people with late-stage AIDS . (epnet.com)
- Dementia related to these conditions is often reversible. (encyclopedia.com)
- Project Inform's AIDS dementia complex (ADC) (HIV/AIDS treatment information). (freethesaurus.com)
- Often treatment begins/continues with the treatment for AIDS/HIV. (iahealth.net)
- It is recommended that a HIV/AIDS-knowledgeable psychiatrist be consulted when considering treatment options. (dementia.org)
- A pilot study of L-methionine for the treatment of AIDS-associated myelopathy. (springer.com)
- It's common in people with AIDS who aren't getting treatment and also in children with HIV. (hopkinsmedicine.org)
- Before effective treatment was available, HIV caused serious neurological conditions including dementia. (poz.com)
- To clone and express the HIV -1B gp120 genes isolated at different organizations from a patient died of AIDS dementia complex (ADC) in eukaryotic cells . (bvsalud.org)
- But they can also happen from other side effects of HIV and AIDS, such as cancers, that are tied to these diseases. (hopkinsmedicine.org)
- The persistence of immune activation, even in long-term combination antiretroviral therapy (cART)-treated individuals, is associated with an increased risk of AIDS and non-AIDS morbidities, including cardiovascular disease, cancers, and modulated neurocognition ( 5 , 6 ). (jimmunol.org)
- Induction of monocyte chemoattractant protein-1 in HIV-1 Tat-stimulated astrocytes and elevation in AIDS dementia. (springer.com)
- Available at: https://www.hopkinsmedicine.org/health/conditions-and-diseases/hiv-and-aids/hiv-and-dementia. (epnet.com)
- Dementia related to infectious diseases. (encyclopedia.com)
- The NINDS works closely with the National Institute of Allergy and Infectious Diseases (NIAID), which has primary responsibility for research related to HIV and AIDS. (nih.gov)
- AIDS Dementia Complex (ADC) or HIV-associated dementia is common among people with advanced HIV disease (usually very low T cell counts). (freethesaurus.com)
- Dementia is somewhat more common in women than in men. (thefreedictionary.com)
- AIDS dementia complex is a common complication of human immunodeficiency virus type 1 (HIV-1) that continues to exist despite the current use of potent antiretroviral therapy. (essentialevidenceplus.com)
- 9 The AIDS Clinical Trials Group HIV Reservoirs Cohort Study group is detailed in the Supplemental Acknowledgments. (jci.org)