AIDS Dementia Complex
Peptide T
Dementia
Acquired Immunodeficiency Syndrome
HIV-1
Zidovudine
Cycas
Brain
HIV Envelope Protein gp120
Dementia, Vascular
HIV Core Protein p24
Cerebral vasculopathy in HIV infection revealed by transcranial Doppler: A pilot study. (1/587)
BACKGROUND AND PURPOSE: There is growing evidence for affection of cerebral vessels during human immunodeficiency virus (HIV) infection. We prospectively evaluated cerebrovascular reserve capacity (CRC) in HIV-seropositive patients by transcranial Doppler sonography (TCD) after systemic administration of acetazolamide. We hypothesized that a disturbed vasoreactivity would reflect the cerebral arteries' involvement in HIV infection. METHODS: We assessed the mean blood flow velocity (BFV) of the middle cerebral artery and its increase after intravenous administration of 1 g acetazolamide (CRC) in 31 HIV-infected individuals without symptoms of cerebrovascular disease (mean+/-SD age, 39+/-11 years). Stenotic or occlusive lesions of the large brain-supplying arteries were excluded by color-coded duplex and transcranial imaging. BFV and CRC were also measured in an age-matched group of 10 healthy control subjects. Patients were classified according to clinical, laboratory, and neurophysiological parameters. We also performed cerebral MRI (n=25) and rheumatological blood tests (n=26). RESULTS: Baseline BFV and CRC both were significantly reduced in HIV-infected patients as compared with control subjects (P<0.05, Student's t test). These findings did not correlate with duration of seropositivity, helper cell count, or other clinical, rheumatological, and neuroradiological findings. CONCLUSIONS: Our findings support the hypothesis of a cerebral vasculopathy etiologically associated with HIV infection. (+info)Proton magnetic resonance spectroscopy pattern of progressive multifocal leukoencephalopathy in AIDS. (2/587)
The objective was to determine whether the use of intermediate echo times (135 ms) in proton magnetic resonance spectroscopy (1H-MRS) detects a homogenous pattern in progressive multifocal leukoencephalopathy (PML) in HIV-1 infected people, and to confirm the results of previous studies. Six patients infected with HIV-1, with PML established by biopsy, and six healthy age and sex matched volunteers were evaluated to define their spectroscopic pattern. 1H-MRS spectra performed at 1.5 T were obtained with the STEAM sequence: TE/TM/TR, 20 ms/13.7 ms/2000 ms; 2500 Hz, size 2048 points, 256 acquisitions (STEAM-20) and with the PRESS sequence; TE/TR, 135 ms/2000 ms; 2500 Hz, size 2048 points, 256 acquisitions (PRESS-135). A single voxel was placed on the lesions and on the parieto-occipital white matter of controls. The peaks of N-acetylaspartate (NAA), choline (Cho), myoinositol (mI), lactate, and lipids were considered, and the results were expressed using creatine as reference. Spectra of PML lesions were characterised by significantly reduced NAA, lactate presence, and by significantly increased Cho and lipids compared with control group values. These results indicate that 1H-MRS detects a homogenous pattern in PML lesions. Recent studies, together with this, suggest that 1H-MRS may help in the diagnostic approach to patients with suspected PML lesions associated with AIDS. (+info)Increased peroxynitrite activity in AIDS dementia complex: implications for the neuropathogenesis of HIV-1 infection. (3/587)
Oxidative stress is suggested to be involved in several neurodegenerative diseases. One mechanism of oxidative damage is mediated by peroxynitrite, a neurotoxic reaction product of superoxide anion and nitric oxide. Expression of two cytokines and two key enzymes that are indicative of the presence of reactive oxygen intermediates and peroxynitrite was investigated in brain tissue of AIDS patients with and without AIDS dementia complex and HIV-seronegative controls. RNA expression of IL-1beta, IL-10, inducible nitric oxide synthase, and superoxide dismutase (SOD) was found to be significantly higher in demented compared with nondemented patients. Immunohistochemical analysis showed that SOD was expressed in CD68-positive microglial cells while inducible nitric oxide synthase was detected in glial fibrillary acidic protein (GFAP)-positive astrocytes and in equal amounts in microglial cells. Approximately 70% of the HIV p24-Ag-positive macrophages did express SOD, suggesting a direct HIV-induced intracellular event. HIV-1 infection of macrophages resulted in both increased superoxide anion production and elevated SOD mRNA levels, compared with uninfected macrophages. Finally, we show that nitrotyrosine, the footprint of peroxynitrite, was found more intense and frequent in brain sections of demented patients compared with nondemented patients. These results indicate that, as a result of simultaneous production of superoxide anion and nitric oxide, peroxynitrite may contribute to the neuropathogenesis of HIV-1 infection. (+info)Rate and severity of HIV-associated dementia (HAD): correlations with Gp41 and iNOS. (4/587)
BACKGROUND: Fifteen to thirty percent of AIDS patients develop some type of neurologic disorder during the course of their illness and the vast majority of these neurologic disorders will be HIV-associated dementia (HAD). These patients can exhibit varying degrees of severity and rates of progression of HAD. Neuropathologic variables that are associated with the rate of progression of HAD are not known. MATERIALS AND METHODS: Tissue was collected at autopsy from the Johns Hopkins University HIV Neurology Program. Seventy-one AIDS patients of this prospectively characterized population were followed until death to obtain information on dementia severity and the rate of neurological progression. Immunoblot analysis of immunological nitric oxide synthase (iNOS), HAM56, gp41, p24, gp120, and beta-tubulin was performed and the levels of iNOS, HAM56, gp41, and p24 were normalized to beta-tubulin and analyzed for significance by means of the Kruskal-Wallis test for multiple groups. RESULTS: We have identified unique groups within this spectrum and designated them slow, moderate, and rapid progressors. Slow and moderate progressors' neurological progression occurs over a course of months to years, whereas the rapid progressors' disease shows rapid increases in severity over weeks to months. In the present study we demonstrate that the severity and rate of progression of HAD correlates significantly with levels of the HIV-1 coat protein, gp41, iNOS, and HAM56, a marker of microglial/macrophage activation. CONCLUSION: The severity and rate of progression of HAD correlates with indices of immune activation as well as levels of iNOS and gp41. There appears to be a threshold effect in which high levels of gp41, iNOS, and immune activation are particularly associated with severe (Memorial Sloan-Kettering score 3 to 4) and rapidly progressive HAD. (+info)The SIV-infected rhesus monkey model for HIV-associated dementia and implications for neurological diseases. (5/587)
The neuropathogenesis of human immunodeficiency virus (HIV)-associated dementia has remained elusive, despite identification of HIV as the causal agent. Although a number of contributing factors have been identified, the series of events that culminate in motor and cognitive impairments after HIV infection of the central nervous system (CNS) are still not known. Rhesus monkeys infected with simian immunodeficiency virus (SIV) manifest immunosuppression and CNS disease that is pathologically [L. R. Sharer et al. (1991) J. Med. Primatol. 20, 211-217] and behaviorally [E. A. Murray et al. (1992) Science 255, 1246-1249] similar to humans. The SIV model of HIV-associated dementia (HAD) is widely recognized as a highly relevant model in which to investigate neuropathogenesis. With better understanding of neuropathogenesis comes the opportunity to interrupt progression and to design better treatments for HAD. This becomes increasingly important as patients live longer yet still harbor HIV-infected cells in the CNS. The use of the SIV model has allowed the identification of neurochemical markers of neuropathogenesis important not only for HAD, but also for other inflammatory neurological diseases. (+info)Do alcohol and cocaine abuse alter the course of HIV-associated dementia complex? (6/587)
Although psychoactive drugs are commonly used by AIDS patients, it is unclear whether commonly abused drugs, such as cocaine and ethanol, affect the course of HIV-associated dementia (HADC). Epidemiological studies have resulted in conflicting conclusions as to what role, if any, abused drugs play in HADC. In this review we discuss the clinical and pathological evidence that cocaine and ethanol might exacerbate the detrimental effects of HIV infection on the brain. We also review studies of cocaine and ethanol effects on various components of the immune system both in the presence and absence of retroviral infection. Data from these studies indicate that cocaine and ethanol have profound effects on the immune system that, in many respects, are enhanced by retroviral infection. We conclude that abused drugs likely affect the course of HADC but that proof awaits an examination of their interactive effects in an appropriate in vivo system of retroviral encephalitis. (+info)Angiographic abnormalities in progressive multifocal leukoencephalopathy: an explanation based on neuropathologic findings. (7/587)
BACKGROUND AND PURPOSE: Progressive multifocal leukoencephalopathy (PML) is typically occult at angiography and fails to enhance on MR images. After observing angiographic abnormalities characterized by arteriovenous shunting and pathologic parenchymal blush in patients with AIDS-related PML, often in the absence of contrast enhancement on MR images, we hypothesized that there might be distinct changes in the cerebral microvasculature that account for the reduction in vascular transit time (arteriovenous shunting) in the absence of blood-brain barrier dysfunction. METHODS: The imaging studies and neuropathologic specimens of six patients with biopsy-proved PML were reviewed retrospectively. In all patients contrast-enhanced MR imaging and CT, followed by cerebral angiography, were performed before stereotactically directed biopsy. The angiograms were evaluated for the presence of vascular displacement, pathologic parenchymal blush, arteriovenous shunting, and neovascularity. The CT and MR studies were reviewed for the presence of enhancement of the PML lesions. Biopsy specimens were examined for the presence of necrosis, perivascular inflammation, and neovascularity. RESULTS: All patients had oligodendrocytic intranuclear inclusions diagnostic of PML, together with perivascular inflammation and neovascularity to a varying extent; no other neuropathologic processes were identified. Angiographic abnormalities, characterized by a pathologic parenchymal blush and arteriovenous shunting, were identified in four of the six patients. In only one of these cases, however, was abnormal enhancement identified on cross-sectional imaging studies (MR and CT), and this patient had florid perivascular inflammatory infiltrates histologically. CONCLUSION: The pathologic parenchymal blush and arteriovenous shunting seen angiographically in some patients with PML reflect small-vessel proliferation and perivascular inflammatory changes incited by the presence of the JC virus in infected oligodendrocytes. (+info)Bipolar disorder in old age. (8/587)
OBJECTIVE: To review the classification, clinical characteristics, and epidemiology of bipolar disorders in old age with a special focus on neurologic comorbidity, high mortality, and management. QUALITY OF EVIDENCE: Most available data is gleaned from retrospective chart reviews and cohort studies. Treatment recommendations are based on evidence from younger populations and a few anecdotal case reports and series involving elderly people. MAIN MESSAGE: While relatively rare in the community setting, mania in old age frequently leads to hospitalization. It is associated with late-onset neurologic disorders (especially cerebrovascular disease) involving the right hemisphere and orbitofrontal cortex. Prognosis is relatively poor; morbidity and mortality rates are high. Management of bipolarity includes cautious use of mood stabilizers, especially lithium and divalproex. CONCLUSIONS: Mania in old age should trigger a careful assessment of underlying neurologic disease, especially cerebrovascular disease. Close clinical follow up is essential. (+info)The exact cause of ADC is not fully understood, but it is believed to be related to the progression of HIV infection in the brain. As HIV replicates in the brain, it can damage brain cells and disrupt normal brain function.
ADC typically affects individuals who have advanced HIV infection and a low CD4 cell count (a measure of immune system health). It is more common in women than men and tends to occur at an older age.
There are several symptoms of ADC, including:
1. Cognitive impairment: difficulty with memory, concentration, and decision-making.
2. Changes in personality and behavior: depression, anxiety, and agitation.
3. Difficulty with speech and language: slurred speech, trouble finding the right words.
4. Coordination and balance problems: unsteadiness, tremors, and difficulty with movement.
5. Seizures: ADC can cause seizures, which can be a sign of a more severe form of the disorder.
There is no cure for ADC, but treatment can help manage its symptoms and slow its progression. Treatment typically involves a combination of antiretroviral therapy (ART) to suppress HIV replication, and medications to manage cognitive and behavioral symptoms. In addition, supportive care, such as physical therapy and occupational therapy, can help improve quality of life.
In conclusion, AIDS Dementia Complex (ADC) is a serious neurological disorder that affects individuals with advanced HIV infection. It is characterized by cognitive impairment, changes in personality and behavior, and difficulty with speech and movement. While there is no cure for ADC, treatment can help manage its symptoms and slow its progression.
There are several types of dementia, each with its own set of symptoms and characteristics. Some common types of dementia include:
* Alzheimer's disease: This is the most common form of dementia, accounting for 50-70% of all cases. It is a progressive disease that causes the death of brain cells, leading to memory loss and cognitive decline.
* Vascular dementia: This type of dementia is caused by problems with blood flow to the brain, often as a result of a stroke or small vessel disease. It can cause difficulty with communication, language, and visual-spatial skills.
* Lewy body dementia: This type of dementia is characterized by the presence of abnormal protein deposits called Lewy bodies in the brain. It can cause a range of symptoms, including memory loss, confusion, hallucinations, and difficulty with movement.
* Frontotemporal dementia: This is a group of diseases that affect the front and temporal lobes of the brain, leading to changes in personality, behavior, and language.
The symptoms of dementia can vary depending on the underlying cause, but common symptoms include:
* Memory loss: Difficulty remembering recent events or learning new information.
* Communication and language difficulties: Struggling to find the right words or understand what others are saying.
* Disorientation: Getting lost in familiar places or having difficulty understanding the time and date.
* Difficulty with problem-solving: Trouble with planning, organizing, and decision-making.
* Mood changes: Depression, anxiety, agitation, or aggression.
* Personality changes: Becoming passive, suspicious, or withdrawn.
* Difficulty with movement: Trouble with coordination, balance, or using utensils.
* Hallucinations: Seeing or hearing things that are not there.
* Sleep disturbances: Having trouble falling asleep or staying asleep.
The symptoms of dementia can be subtle at first and may progress slowly over time. In the early stages, they may be barely noticeable, but as the disease progresses, they can become more pronounced and interfere with daily life. It is important to seek medical advice if you or a loved one is experiencing any of these symptoms, as early diagnosis and treatment can help improve outcomes.
The symptoms of AIDS can vary depending on the individual and the stage of the disease. Common symptoms include:
1. Fever
2. Fatigue
3. Swollen glands
4. Rash
5. Muscle aches and joint pain
6. Night sweats
7. Diarrhea
8. Weight loss
9. Memory loss and other neurological problems
10. Cancer and other opportunistic infections.
AIDS is diagnosed through blood tests that detect the presence of HIV antibodies or the virus itself. There is no cure for AIDS, but antiretroviral therapy (ART) can help manage the symptoms and slow the progression of the disease. Prevention methods include using condoms, pre-exposure prophylaxis (PrEP), and avoiding sharing needles or other injection equipment.
In summary, Acquired Immunodeficiency Syndrome (AIDS) is a severe and life-threatening condition caused by the Human Immunodeficiency Virus (HIV). It is characterized by a severely weakened immune system, which makes it difficult to fight off infections and diseases. While there is no cure for AIDS, antiretroviral therapy can help manage the symptoms and slow the progression of the disease. Prevention methods include using condoms, pre-exposure prophylaxis, and avoiding sharing needles or other injection equipment.
The symptoms of vascular dementia can vary depending on the location and severity of the damage to the brain, but common symptoms include:
* Memory loss, such as difficulty remembering recent events or learning new information
* Confusion and disorientation
* Difficulty with communication, including trouble finding the right words or understanding what others are saying
* Difficulty with problem-solving, decision-making, and judgment
* Mood changes, such as depression, anxiety, or agitation
* Personality changes, such as becoming more passive or suspicious
* Difficulty with coordination and movement, including trouble walking or balance
Vascular dementia can be caused by a variety of conditions that affect the blood vessels in the brain, including:
* Stroke or transient ischemic attack (TIA, or "mini-stroke")
* Small vessel disease, such as tiny strokes or changes in the blood vessels that occur over time
* Moyamoya disease, a rare condition caused by narrowing or blockage of the internal carotid artery and its branches
* Cerebral amyloid angiopathy, a condition in which abnormal protein deposits build up in the blood vessels of the brain
* Other conditions that can cause reduced blood flow to the brain, such as high blood pressure, diabetes, or cardiovascular disease
There is no cure for vascular dementia, but there are several treatment options available to help manage its symptoms and slow its progression. These may include medications to improve memory and cognitive function, physical therapy to maintain mobility and strength, and lifestyle changes such as a healthy diet and regular exercise. In some cases, surgery or endovascular procedures may be recommended to treat the underlying cause of the dementia, such as a stroke or blocked blood vessel.
It is important for individuals with vascular dementia to receive timely and accurate diagnosis and treatment, as well as ongoing support and care from healthcare professionals, family members, and caregivers. With appropriate management, many people with vascular dementia are able to maintain their independence and quality of life for as long as possible.
Jack Picone
B22
Gliosis
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Peptide T
AIDS Clinical Trials Group
Causes of mental disorders
Hearing
Alzheimer's disease
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Neuroserpin
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List of neurological conditions and disorders
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Encephalopathy3
- HIV-associated progressive encephalopathy (HPE) is a syndrome complex with cognitive, motor, and behavioral features seen in children. (medscape.com)
- HIV-associated encephalopathy and dementia were among the most common diagnoses in people with AIDS at the time of death [ 3 , 4 ]. (biomedcentral.com)
- HAD is often referred to as AIDS dementia complex (ADC) or HIV encephalopathy. (h-i-v.net)
Acquired immunode9
- It was usually observed in the late stages of acquired immunodeficiency syndrome (AIDS), when CD4 + lymphocyte counts fall below 200 cells/mL, and was seen in up to 50% of patients prior to their deaths. (medscape.com)
- BACKGROUND: Acquired immunodeficiency syndrome (AIDS) is associated with a high rate of pulmonary infections (bacteria, fungi, and viruses). (bvsalud.org)
- Acquired immunodeficiency syndrome (AIDS) is the final stage of HIV. (dgsmith.org)
- Human immunodeficiency virus (HIV), the causative viral organism of acquired immunodeficiency syndrome (AIDS), was first recognized over 20 years ago, and has since infected approximately 50 million people worldwide. (clinicalpainadvisor.com)
- As of August 10, 1987, physicians and health departments in the United States had reported 40,051 patients (39,493 adults and 558 children) meeting the current case definition for national reporting of the acquired immunodeficiency syndrome (AIDS) (1-3). (cdc.gov)
- Update: acquired immunodeficiency syndrome (AIDS)--United States. (cdc.gov)
- Assurance of Confidentiality The data and documentation files on the enclosed diskettes contain informa- tion abstracted from acquired immunodeficiency syndrome (AIDS) case reports received by CDC. (cdc.gov)
- BACKGROUND In 1981, after early reports of Pneumocystis carinii pneumonia, Kaposi's sarcoma, and other opportunistic infections in young homosexual men in Los Angeles, New York City, and San Francisco, CDC began surveillance for a newly recognized constellation of diseases, now termed the acquired immunodeficiency syndrome (AIDS). (cdc.gov)
- 1. AIDS: Acquired immune deficiency syndrome Acquired immunodeficiency syndrome 2. (cdc.gov)
Cognitive6
- The term AIDS dementia complex (ADC) was coined as a diagnosis of severe decline secondary to HIV, typically involving areas of cognitive, motor, and behavioral function [ 3 ]. (biomedcentral.com)
- HAND encompasses a range of cognitive impairment from mild cognitive difficulties with no functional impairment (asymptomatic neurocognitive impairment, or ANI) to cognitive difficulties with mild functional impairment (mild neurocognitive disorder, or MND) to dementia with significant functional impairment (HIV-associated dementia, or HAD). (biomedcentral.com)
- A 38-year-old female with profound motor and cognitive impairment was diagnosed with AIDS dementia complex (ADC) by neurological, radiological (MRI/MRS) and HIV RNA levels. (unthsc.edu)
- There are many different types of dementia and other similar cognitive disorders that can result from HIV. (h-i-v.net)
- HAND can then be broken down into less severe cognitive disorders, including minor neurocognitive disorder (MND) and more severe disorders, like HIV-associated dementia (HAD). (h-i-v.net)
- A less severe version of HAD, called minor cognitive motor disorder (MCMD), has become one of the most common versions of HIV-related dementia and may be more manageable. (h-i-v.net)
Neurocognitive2
- The spectrum ranges from asymptomatic neurocognitive impairment (ANI) to minor neurocognitive disorder (MND) to more severe HIV-associated dementia (HAD). (medscape.com)
- Human immunodeficiency virus (HIV) infection is known to cause brain injury and neurocognitive impairment, variously termed HIV associated dementia or AIDS dementia complex (ADC), and primarily affecting areas of mental processing, behaviour, and motor control. (bmj.com)
Disorder3
- AIDS dementia complex (ADC) is a nervous system disorder that harms the neurons in different parts of the brain. (bvsalud.org)
- Dementia with Lewy bodies is a nervous system disorder characterized by a decline in intellectual function (dementia), a group of movement problems known as parkinsonism, visual hallucinations, sudden changes (fluctuations) in behavior and intellectual ability, and acting out dreams while asleep (REM sleep behavior disorder). (medlineplus.gov)
- REM sleep behavior disorder may be the first sign of dementia with Lewy bodies. (medlineplus.gov)
Severe3
- Dementia can also be caused by changes in blood flow in the brain, including strokes, brain bleeds, or long-term, severe high blood pressure. (h-i-v.net)
- While these acronyms can be confusing, they are referring to one large spectrum of dementia-related disorders and are classified based on how severe a person's symptoms are. (h-i-v.net)
- Thankfully, severe dementia is decreasing among those living with HIV due to ART and better control of the virus. (h-i-v.net)
Diagnosis3
- A doctor makes a diagnosis of dementia based on a variety of factors. (h-i-v.net)
- CONCLUSIONS: In conclusion, mNGS analysis provides fast and precise pathogen detection and identification, contributing substantially to the accurate diagnosis, real-time monitoring, and treatment appropriateness of pulmonary infection in patients with AIDS. (bvsalud.org)
- The median interval between diagnosis of an AIDS case and notification of CDC is 2 months. (cdc.gov)
Symptoms4
- Essentially, dementia related to HIV is a spectrum of disorders and symptoms. (h-i-v.net)
- This could cause direct damage and lead to dementia-related symptoms. (h-i-v.net)
- The symptoms of dementia can be hard to spot. (h-i-v.net)
- When symptoms are very mild and testing does not show an obvious cause but a doctor is still suspicious of HIV-associated dementia, neuropsychological testing may be helpful. (h-i-v.net)
Morbidity2
- Prior to the advent of highly active antiretroviral therapy (HAART), dementia was a common source of morbidity and mortality in HIV-infected patients. (medscape.com)
- The advent of combination antiretroviral therapy (cART) in the late 1990s led to reductions in HIV-associated mortality and morbidity [ 5 ] and a precipitous decline in incidence of dementia [ 12 ]. (biomedcentral.com)
Chronic1
- Because, historically, most health departments have not required reporting of the additional manifestations of human immunodeficiency virus (HIV) infection included in the expanded case definition (HIV dementia complex, chronic wasting syndrome, etc.), the number of cases that will be added to existing case counts as a result of this revision is unknown. (cdc.gov)
Antiretroviral1
- Prior to the availability of antiretroviral drugs, dementia occurred in over 20% of HIV-infected people [ 4 ]. (biomedcentral.com)
Manifestations1
- Clinical manifestations also include emaciation (wasting) and dementia. (bvsalud.org)
Common2
- They may also look for common causes of dementia, including testing the blood for infections, vitamin deficiencies, and HIV viral load. (h-i-v.net)
- It accounts for about 5 percent of all dementia cases in older individuals and is the second most common dementia after Alzheimer's disease . (medlineplus.gov)
Diseases6
- AIDS Program, Center for Infectious Diseases, CDC. (cdc.gov)
- In comparison to many reportable diseases, the reporting level for AIDS has been high (5). (cdc.gov)
- With this revision, AIDS cases involving patients with presumptively diagnosed indicator diseases, which were previously not reportable because they lacked biopsy or other specific confirmation required by the former surveillance case definition, will now be reportable. (cdc.gov)
- Since most patients with the wasting syndrome and HIV dementia develop the opportunistic diseases included in the previous AIDS case definition, addition of these conditions to the case definition may result in earlier reporting without adding substantially to the ultimate case count. (cdc.gov)
- AIDS surveillance in the United States has achieved a high degree of completeness relative to other notifiable diseases. (cdc.gov)
- General Information The AIDS Public Information Data Set is created twice a year by the Division of HIV/AIDS, National Center for Infectious Diseases, Centers for Disease Control (CDC) and consists of a data file containing 44 variables extracted from CDC's national AIDS surveillance data base and a documentation file which contains cross tabulations of 8 of these variables. (cdc.gov)
Malignant1
- In some patients with AIDS, EBV may induce the formation of malignant B-cell lymphomas or oral hairy leukoplakia. (pressbooks.pub)
Term2
- In 1986, the term HIV-associated dementia (HAD) was introduced to describe a unique constellation of neurobehavioral findings. (medscape.com)
- The French long-term care (LTC) sector is complex with multiple funders and care providers managed by different levels of government. (who.int)
Infection3
- Six patients who presented with rapidly progressive dementia within four to 12 weeks of the primary manifestation of their HIV infection were evaluated. (bmj.com)
- to be applied?APRICOT : AIDS Pegasys Ribavirin International CO-infection Trial?APSAC: Anisolyated plasminogen streptokinase activator complex?APT: Alum-precipitated toxoid?aPTT: Activated partial thromboplastin time?APTT: Activated partial thromboplastin time?aq. (kuwaitpharmacy.com)
- In addition, the surveillance system has been modified as understanding of AIDS and HIV infection has grown. (cdc.gov)
People4
- The National Institutes of Health recommends prescription hearing aids for people who do not hear louder sounds or struggle to hear conversations in quiet settings. (theentcenter.com)
- Most people with dementia with Lewy bodies experience visual hallucinations, which often involve people or animals. (medlineplus.gov)
- Parkinsonism is usually the last major feature to develop in people with dementia with Lewy bodies, although it can appear earlier in some individuals. (medlineplus.gov)
- Dementia with Lewy bodies is estimated to affect 1.4 million people in the United States. (medlineplus.gov)
Importantly1
- Importantly, many of the effects described here are related to the failure of the immune system in progressing HIV and AIDS. (dgsmith.org)
Clinical2
- Epidemiologic and clinical AIDS patient information is reported through state and local health departments to CDC on a standard, confidential case report form. (cdc.gov)
- As described in the MMWR supplement being released this week, CDC, in consultation with state and local public health officials and clinical specialists, has revised the case definition for national reporting of AIDS (8). (cdc.gov)
Cases6
- In the United States, there are between 850,000 to 1 million cases of HIV/AIDS, with 40,000 new infections documented per year. (clinicalpainadvisor.com)
- The number of AIDS cases reported per year continues to increase in all patient groups (Table 1). (cdc.gov)
- AIDS cases have been reported from all 50 states, the District of Columbia, and four U.S. territories. (cdc.gov)
- At present, an estimated 6,000 to 8,000 AIDS cases (15% to 20% of the total number of cases) have been diagnosed and will be reported soon to CDC. (cdc.gov)
- Data from this review suggest that 11% of AIDS cases are not reported to state and local public health departments, primarily because of breakdowns in established reporting procedures (e.g., absence of the individual responsible for reporting when the case was diagnosed). (cdc.gov)
- As the epidemic became more widespread, state and local health departments began to assume the responsibility for AIDS surveillance, and by 1985 all states had regulations requiring physicians and other health-care providers to report AIDS cases directly to state or local health departments. (cdc.gov)
Completeness1
- In late 1985, a 3-month review of death certificates was conducted in four major U.S. cities to assess the completeness of AIDS case reporting (4). (cdc.gov)
Develop3
- Not everyone with HIV will go on to develop AIDS. (dgsmith.org)
- This behavior becomes less pronounced as dementia with Lewy bodies worsens and additional features develop. (medlineplus.gov)
- Dementia is often the second major feature to develop in dementia with Lewy bodies. (medlineplus.gov)
Conditions1
- AIDS-like syndrome: AIDS-like disease (illness) (syndrome) ARC AIDS-related complex Pre-AIDS AIDS-related conditions Prodromal-AIDS 3. (cdc.gov)
Condition2
- One serious comorbid condition is dementia. (h-i-v.net)
- In this condition, dementia often leads to impaired ability to perform visual-spatial tasks such as assembling puzzles. (medlineplus.gov)
Form1
- Human immunodeficiency virus (HIV) leucoencephalopathy (HIVL) is an uncommon and rapidly progressive form of AIDS dementia complex (ADC) that has remained poorly understood. (bmj.com)
Include1
- Most areas employ multifaceted active surveillance programs that include four major sources of AIDS information: hospitals and hospital-based physicians, physicians in nonhospital practices, public and private clinics, and medical records systems (death certificates, tumor registries, hospital discharge abstracts, and communicable disease reports). (cdc.gov)
Surveillance6
- AIDS surveillance is conducted by health departments in each state, territory, and the District of Columbia. (cdc.gov)
- AIDS: Public Information Data (1991) ABSTRACT Summary Public health surveillance represents an ongoing and regular collection, analysis, interpretation, and application of health data for disease prevention and control. (cdc.gov)
- AIDS surveillance, like other national surveillance efforts, depends on health-care providers and the state and local health departments and, thus, requires a balance between information needs versus practical limitations. (cdc.gov)
- Users of the AIDS Public Information Data Set should be familiar with the characteristics of public-health surveillance in general as well as with the evolution of AIDS surveillance. (cdc.gov)
- Section 1, AIDS Surveillance in the United States, describes the data collection process and the effect changes in this process may have on data analysis and interpretation. (cdc.gov)
- The section reviews the source of AIDS surveillance data and describes which patients are included in the Centers for Disease Control (CDC) definition for AIDS. (cdc.gov)
Time2
- Your hearing loss may change with time and require adjustments to your hearing aids. (theentcenter.com)
- Affected individuals may require walking aids or wheelchair assistance over time. (medlineplus.gov)
General1
- seul un traitement medical symptomatique est propose en general aux patients victimes d'hemorragie cerebrale. (bvsalud.org)
Experience1
- Individuals with dementia with Lewy bodies may also experience a sharp drop in blood pressure upon standing ( orthostatic hypotension ), fainting episodes (syncope), reduced sense of smell, increased saliva production and drooling, difficulty controlling the flow of urine (incontinence), or constipation. (medlineplus.gov)
Older1
- According to one study, almost 86% of Americans 50 and older with hearing loss do not wear hearing aids . (theentcenter.com)
Percent1
- One study found that 73% percent of participants picked the wrong aid based on their audiogram. (theentcenter.com)
Physicians1
- Hearing loss experts, including our physicians and audiologists at Georgia Hearing Institute, can provide the hearing aid that will serve you best and program it to fit your hearing needs and lifestyle. (theentcenter.com)
Disease2
- Estos elementos reflejan los criterios de SIDA definidos por los CDC (Centers for Disease Control and Prevention) en 1993. (bvsalud.org)
- It is not considered an AIDS-defining disease. (bvsalud.org)
Provide1
- Hearing loss experts do more than provide you with hearing aids. (theentcenter.com)
Cells1
- Ultimately, a rising viral count, extreme compromise of the immune system, and a CD4+ cell count of fewer than 200 cells/mL heralds the onset of AIDS. (clinicalpainadvisor.com)
Increase1
- There are multiple versions of the APOE gene, one version, called the e4 allele, seems to increase an individual's risk for developing dementia with Lewy bodies, although the mechanism is unclear. (medlineplus.gov)
Require1
- Over-the-counter hearing aids, which do not require a prescription, might seem like a straightforward way to get treatment for your hearing loss. (theentcenter.com)