A decrease in the number of GRANULOCYTES; (BASOPHILS; EOSINOPHILS; and NEUTROPHILS).
Agents that are used to treat hyperthyroidism by reducing the excessive production of thyroid hormones.
A thioureylene antithyroid agent that inhibits the formation of thyroid hormones by interfering with the incorporation of iodine into tyrosyl residues of thyroglobulin. This is done by interfering with the oxidation of iodide ion and iodotyrosyl groups through inhibition of the peroxidase enzyme.
An antihelminthic drug that has been tried experimentally in rheumatic disorders where it apparently restores the immune response by increasing macrophage chemotaxis and T-lymphocyte function. Paradoxically, this immune enhancement appears to be beneficial in rheumatoid arthritis where dermatitis, leukopenia, and thrombocytopenia, and nausea and vomiting have been reported as side effects. (From Smith and Reynard, Textbook of Pharmacology, 1991, p435-6)
A tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a major adverse effect associated with administration of this agent.
The presence of organisms, or any foreign material that makes a drug preparation impure.
A thiourea antithyroid agent. Propythiouracil inhibits the synthesis of thyroxine and inhibits the peripheral conversion of throxine to tri-iodothyronine. It is used in the treatment of hyperthyroidism. (From Martindale, The Extra Pharmacopeoia, 30th ed, p534)
Drugs used by veterinarians in the treatment of animal diseases. The veterinarian's pharmacological armamentarium is the counterpart of drugs treating human diseases, with dosage and administration adjusted to the size, weight, disease, and idiosyncrasies of the species. In the United States most drugs are subject to federal regulations with special reference to the safety of drugs and residues in edible animal products.
A butyl-diphenyl-pyrazolidinedione that has anti-inflammatory, antipyretic, and analgesic activities. It has been used in ANKYLOSING SPONDYLITIS; RHEUMATOID ARTHRITIS; and REACTIVE ARTHRITIS.
Compounds with two BENZENE rings fused to AZEPINES.
A sulfonylurea hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. (From Martindale, The Extra Pharmacopoeia, 30th ed, p277)
A common form of hyperthyroidism with a diffuse hyperplastic GOITER. It is an autoimmune disorder that produces antibodies against the THYROID STIMULATING HORMONE RECEPTOR. These autoantibodies activate the TSH receptor, thereby stimulating the THYROID GLAND and hypersecretion of THYROID HORMONES. These autoantibodies can also affect the eyes (GRAVES OPHTHALMOPATHY) and the skin (Graves dermopathy).
A specific HLA-B surface antigen subtype. Members of this subtype contain alpha chains that are encoded by the HLA-B*38 allele family.
Substances used in the treatment or control of nematode infestations. They are used also in veterinary practice.
A major metabolite of PROCAINAMIDE. Its anti-arrhythmic action may cause cardiac toxicity in kidney failure.
A drug that has analgesic, anti-inflammatory, and antipyretic properties. It is the sodium sulfonate of AMINOPYRINE.
A hypnotic and sedative. Its use has been largely superseded by other drugs.
An oxyacid of chlorine (HClO) containing monovalent chlorine that acts as an oxidizing or reducing agent.
A carbamate with hypnotic, sedative, and some muscle relaxant properties, although in therapeutic doses reduction of anxiety rather than a direct effect may be responsible for muscle relaxation. Meprobamate has been reported to have anticonvulsant actions against petit mal seizures, but not against grand mal seizures (which may be exacerbated). It is used in the treatment of ANXIETY DISORDERS, and also for the short-term management of INSOMNIA but has largely been superseded by the BENZODIAZEPINES. (From Martindale, The Extra Pharmacopoeia, 30th ed, p603)
A form of anemia in which the bone marrow fails to produce adequate numbers of peripheral blood elements.
A constituent organization of the DEPARTMENT OF HEALTH AND HUMAN SERVICES concerned with protecting and improving the health of the nation.
Deficiency of all three cell elements of the blood, erythrocytes, leukocytes and platelets.
The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking DOPAMINE RECEPTORS. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.
Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chemically-induced adverse conditions due to toxicity, DRUG INTERACTIONS, and metabolic effects of pharmaceuticals.
Pyridine derivatives with one or more keto groups on the ring.
The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.
A 4-aminoquinoline compound with anti-inflammatory properties.
Removal of bone marrow and evaluation of its histologic picture.
A glycoprotein of MW 25 kDa containing internal disulfide bonds. It induces the survival, proliferation, and differentiation of neutrophilic granulocyte precursor cells and functionally activates mature blood neutrophils. Among the family of colony-stimulating factors, G-CSF is the most potent inducer of terminal differentiation to granulocytes and macrophages of leukemic myeloid cell lines.
Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus.
A decrease in the number of NEUTROPHILS found in the blood.
Hypersecretion of THYROID HORMONES from the THYROID GLAND. Elevated levels of thyroid hormones increase BASAL METABOLIC RATE.
The process of observing, recording, or detecting the effects of a chemical substance administered to an individual therapeutically or diagnostically.
A hemeprotein from leukocytes. Deficiency of this enzyme leads to a hereditary disorder coupled with disseminated moniliasis. It catalyzes the conversion of a donor and peroxide to an oxidized donor and water. EC 1.11.1.7.
The number of WHITE BLOOD CELLS per unit volume in venous BLOOD. A differential leukocyte count measures the relative numbers of the different types of white cells.
An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat. It also has powerful central nervous system effects similar to the amphetamines and is a drug of abuse. Cocaine, like amphetamines, acts by multiple mechanisms on brain catecholaminergic neurons; the mechanism of its reinforcing effects is thought to involve inhibition of dopamine uptake.
The largest country in North America, comprising 10 provinces and three territories. Its capital is Ottawa.
A publication issued at stated, more or less regular, intervals.
Substances that induce LACTATION.
Encouraging consumer behaviors most likely to optimize health potentials (physical and psychosocial) through health information, preventive programs, and access to medical care.
Process that is gone through in order for a drug to receive approval by a government regulatory agency. This includes any required pre-clinical or clinical testing, review, submission, and evaluation of the applications and test results, and post-marketing surveillance of the drug.
The geographic area of the midwestern region of the United States in general or when the specific state or states are not indicated. The states usually included in this region are Illinois, Indiana, Iowa, Kansas, Kentucky, Michigan, Minnesota, Missouri, Nebraska, Ohio, Oklahoma, North Dakota, South Dakota and Wisconsin.
Education that increases the awareness and favorably influences the attitudes and knowledge relating to the improvement of health on a personal or community basis.

Phase I trial of dolastatin-10 (NSC 376128) in patients with advanced solid tumors. (1/458)

Dolastatin-10 (dola-10) is a potent antimitotic peptide, isolated from the marine mollusk Dolabela auricularia, that inhibits tubulin polymerization. Preclinical studies of dola-10 have demonstrated activity against a variety of murine and human tumors in cell cultures and mice models. The purpose of this Phase I clinical trial was to characterize the maximum tolerated dose, pharmacokinetics, and biological effects of dola-10 in patients with advanced solid tumors. Escalating doses of dola-10 were administered as an i.v. bolus every 21 days, using a modified Fibonacci dose escalation schema. Pharmacokinetic studies were performed with the first treatment cycle. Neurological testing was performed on each patient prior to treatment with dola-10, at 6 weeks and at study termination. Thirty eligible patients received a total of 94 cycles (median, 2 cycles; maximum, 14 cycles) of dola-10 at doses ranging from 65 to 455 microg/m2. Dose-limiting toxicity of granulocytopenia was seen at 455 microg/m2 for minimally pretreated patients (two or fewer prior chemotherapy regimens) and 325 microg/m2 for heavily pretreated patients (more than two prior chemotherapy regimens). Nonhematological toxicity was generally mild. Local irritation at the drug injection site was mild and not dose dependent. Nine patients developed new or increased symptoms of mild peripheral sensory neuropathy that was not dose limiting. This toxicity was more frequent in patients with preexisting peripheral neuropathies. Pharmacokinetic studies demonstrated a rapid drug distribution with a prolonged plasma elimination phase (t 1/2z = 320 min). The area under the concentration-time curve increased in proportion to administered dose, whereas the clearance remained constant over the doses studied. Correlation analysis demonstrated a strong relationship between dola-10 area under the concentration-time curve values and decrease from baseline for leukocyte counts. In conclusion, dola-10 administered every 3 weeks as a peripheral i.v. bolus is well tolerated with dose-limiting toxicity of granulocytopenia. The maximum tolerated dose (and recommended Phase II starting dose) is 400 microg/m2 for patients with minimal prior treatment (two or fewer prior chemotherapy regimens) and 325 microg/m2 for patients who are heavily pretreated (more than two prior chemotherapy regimens).  (+info)

Agranulocytosis in Bangkok, Thailand: a predominantly drug-induced disease with an unusually low incidence. Aplastic Anemia Study Group. (2/458)

Agranulocytosis, a syndrome characterized by a marked reduction in circulating granulocytes, is strongly associated with medical drug use in Europe and the United States. Unregulated use of common pharmaceutical agents in developing countries has been suspected of causing large numbers of cases of agranulocytosis and deaths, especially among children. To elucidate the incidence and etiology of agranulocytosis in Thailand, a population-based case-control study of symptomatic agranulocytosis that resulted in hospital admission was conducted in Bangkok from 1990 to 1994. An attempt was also made to study the disease in Khonkaen (in northeastern Thailand) and Songkla (in southern Thailand), but there were insufficient cases in the latter regions, and the analysis was confined to subjects from Bangkok. In that region, the overall incidence of agranulocytosis was 0.8 per million per year; there were no deaths. As expected, the incidence was higher in females (0.9 per million), and it increased with age (4.3 per million beyond age 60). Among 25 cases and 529 controls the relative risk estimate for a combined category of all suspect drugs was 9.2 (95% confidence interval = 3.9-21), and the proportion of cases that could be attributed to drug use was 68%. For individual drugs and drug classes the data were sparse; within these limitations, the strongest association appeared to be with antithyroid drugs. One case and three controls were exposed to dipyrone, a drug known to cause agranulocytosis; with such scanty data the risk could not be evaluated. Exposure to pesticides or solvents was not associated with an increased risk. This is the first formal epidemiologic study of agranulocytosis in a developing country. As in the West, most cases are attributable to medical drug use. However, the incidence of agranulocytosis in Bangkok, and apparently, in Thailand as a whole, is unusually low, and the disease does not pose a public health risk.  (+info)

Phase I study of a biweekly schedule of a fixed dose of cisplatin with increasing doses of paclitaxel in patients with advanced oesophageal cancer. (3/458)

We performed this dose-finding study with a fixed dose of cisplatin and increasing doses of paclitaxel given every 2 weeks to determine the maximum tolerable dose of this schedule. Sixty-four patients with advanced oesophageal cancer were treated with a cisplatin dose of 60 mg m(-2) and increasing doses of paclitaxel from 100 mg m(-2) up to 200 mg m(-2) both administered over 3 h for a maximum of six cycles in patients with stable disease or eight cycles in responding patients. Patients were retreated when the granulocytes were > 0.75 x 10(9) l(-1) and the platelets > 75 x 10(9) l(-1). The dose of paclitaxel could be increased to 200 mg m(-2) without encountering dose limiting haematological toxicity. At the dose levels 190 mg m(-2) and 200 mg m(-2) of paclitaxel cumulative sensory neurotoxicity became the dose-limiting toxicity. The dose intensity of paclitaxel calculated over six cycles rose from 50 mg m(-2) per week to 85 mg m(-2) per week. Only three episodes of granulocytopenic fever were encountered out of a total of 362 cycles of treatment. Of the 59 patients evaluable for response, 31 (52%) had a partial or complete response. In a biweekly schedule with a fixed dose of 60 mg m(-2) cisplatin it is possible to increase the dose of paclitaxel to 180 mg m(-2). At higher dose levels, neurotoxicity becomes the dose-limiting toxicity. The observed response rate warrants further investigation of this schedule.  (+info)

Oral versus intravenous empirical antimicrobial therapy for fever in patients with granulocytopenia who are receiving cancer chemotherapy. International Antimicrobial Therapy Cooperative Group of the European Organization for Research and Treatment of Cancer. (4/458)

BACKGROUND: Intravenously administered antimicrobial agents have been the standard choice for the empirical management of fever in patients with cancer and granulocytopenia. If orally administered empirical therapy is as effective as intravenous therapy, it would offer advantages such as improved quality of life and lower cost. METHODS: In a prospective, open-label, multicenter trial, we randomly assigned febrile patients with cancer who had granulocytopenia that was expected to resolve within 10 days to receive empirical therapy with either oral ciprofloxacin (750 mg twice daily) plus amoxicillin-clavulanate (625 mg three times daily) or standard daily doses of intravenous ceftriaxone plus amikacin. All patients were hospitalized until their fever resolved. The primary objective of the study was to determine whether there was equivalence between the regimens, defined as an absolute difference in the rates of success of 10 percent or less. RESULTS: Equivalence was demonstrated at the second interim analysis, and the trial was terminated after the enrollment of 353 patients. In the analysis of the 312 patients who were treated according to the protocol and who could be evaluated, treatment was successful in 86 percent of the patients in the oral-therapy group (95 percent confidence interval, 80 to 91 percent) and 84 percent of those in the intravenous-therapy group (95 percent confidence interval, 78 to 90 percent; P=0.02). The results were similar in the intention-to-treat analysis (80 percent and 77 percent, respectively; P=0.03), as were the duration of fever, the time to a change in the regimen, the reasons for such a change, the duration of therapy, and survival. The types of adverse events differed slightly between the groups but were similar in frequency. CONCLUSIONS: In low-risk patients with cancer who have fever and granulocytopenia, oral therapy with ciprofloxacin plus amoxicillin-clavulanate is as effective as intravenous therapy.  (+info)

Murine neutrophil stimulation by Toxoplasma gondii antigen drives high level production of IFN-gamma-independent IL-12. (5/458)

Successful immunity to Toxoplasma gondii requires a strong cell-mediated immune response. Neutrophils possess the ability to rapidly migrate into tissues in response to microbial stimuli. Therefore, we sought to determine whether murine neutrophils could respond to T. gondii by producing immunoregulatory cytokines. We show that murine neutrophils produce high levels of IL-12 and low, but significant, levels of TNF-alpha when stimulated with T. gondii Ag. Both cytokines are produced in the absence of IFN-gamma. Production of IL-12 does not require TNFR p55, and release of TNF-alpha occurs independently of IL-12. We show that there is an influx of neutrophils into the peritoneal cavity that peaks at approximately 8 h in response to injection of live tachyzoites and that this is correlated with increased transcription of IL-12 p40. Our results establish that murine neutrophils possess the ability to produce immunoregulatory cytokines during T. gondii infection and suggest that this response may be important in early host defense and in triggering cell-mediated immunity to the parasite.  (+info)

Different effect of granulocyte colony-stimulating factor or bacterial infection on bone-marrow cells of cyclophosphamide-treated or irradiated mice. (6/458)

In the present study, the effect of treatment with granulocyte colony-stimulating factor (G-CSF) on cellular composition of the bone marrow and the number of circulating leucocytes of granulocytopenic mice, whether or not infected with Staphylococcus aureus, was assessed. With two monoclonal antibodies, six morphologically distinct cell populations in the bone marrow could be characterised and quantitated by two-dimensional flow cytometry. Granulocytopenia was induced by cyclophosphamide or sublethal irradiation. Cyclophosphamide predominantly affected the later stages of dividing cells in the bone marrow resulting in a decrease in number of granulocytic cells, monocytic cells, lymphoid cells and myeloid blasts. G-CSF administration to cyclophosphamide-treated mice increased the number of early blasts, myeloid blasts and granulocytic cells in the bone marrow, which indicates that this growth factor stimulates the proliferation of these cells in the bone marrow. During infection in cyclophosphamide-treated mice the number of myeloid blasts increased. However, when an infection was induced in cyclophosphamide and G-CSF-treated mice, the proliferation of bone-marrow cells was not changed compared to that in noninfected similarly treated mice. Sublethal irradiation affected all bone-marrow cell populations, including the early blasts. G-CSF-treatment of irradiated mice increased only the number of myeloid blasts slightly, whereas an infection in irradiated mice, whether or not treated with G-CSF, did not affect the number of bone-marrow cells. Together, these studies demonstrated that irradiation affects the early blasts and myeloid blasts in the bone marrow more severely than treatment with cyclophosphamide. Irradiation probably depletes the bone marrow from G-CSF-responsive cells, while cyclophosphamide spared G-CSF responsive cells, thus enabling the enhanced G-CSF-mediated recovery after cyclophosphamide treatment. Only in these mice, bone marrow recovery is followed by a strong mobilisation of mature granulocytes and their band forms from the bone marrow into the circulation during a bacterial infection.  (+info)

Fludarabine-based chemotherapy in untreated mantle cell lymphomas: an encouraging experience in 29 patients. (7/458)

BACKGROUND AND OBJECTIVE: A prospective study to evaluate the role of fludarabine alone or in combination with idarubicin in untreated patients with mantle cell lymphoma (MCL). DESIGN AND METHODS: Twenty-nine untreated patients with mantle cell lymphoma were stochastically treated with intravenous fludarabine at a dose of 25 mg/m(2)/day for 5 days (11 patients) or with a combination of fludarabine and idarubicin (FLU-ID) (fludarabine 25 mg/m(2) i.v. on days 1 to 3 and idarubicin 12 mg/m(2) i.v. on day 1 (18 patients). For both regimens, cycles were given at three-week intervals for a total of six courses. According to the International Prognostic Index, the most part of high-intermediate and high risk factor patients were in the FLU-ID subset: 7 (39%) patients vs. 2 (18%) in the fludarabine alone subset. RESULTS: Of the 29 patients, 8 (28%) obtained a complete response and 10 (35%) a partial response, with an overall response rate of 63%. The remaining 11 (37%) patients did not respond to the therapy. The overall response rates were 64% (7 patients) in the fludarabine group and 61% (11 patients) in the FLU-ID group. The complete response rate was 27% (3 patients) for fludarabine and 28% (5 patients) for FLU-ID. The toxicity was mild in terms of neutropenia and infections, and no fatalities occurred due to drug-induced side effects. INTERPRETATION AND CONCLUSIONS: These results suggest the efficacy of fludarabine alone or in combination with idarubicin in MCL patients. It will be important to increase this experience and to assess other fludarabine-containing regimens, in particular with cyclophosphamide plus idarubicin and with mitoxantrone and or cyclophosphamide, to test the true role of this approach in MCL.  (+info)

Gemcitabine plus cisplatin, an active regimen in advanced urothelial cancer: a phase II trial of the National Cancer Institute of Canada Clinical Trials Group. (8/458)

PURPOSE: To evaluate the efficacy and toxicity of gemcitabine (2', 2'-difluorodeoxycytidine) plus cisplatin in previously untreated patients with advanced transitional-cell carcinoma. PATIENTS AND METHODS: Thirty-one patients with measurable advanced transitional-cell carcinoma who had received no prior chemotherapy for metastatic disease were scheduled to receive gemcitabine 1,000 mg/m(2) intravenously over 30 minutes on days 1, 8, and 15 and cisplatin 70 mg/m(2) over 1 hour on day 2 of a 28-day cycle. Prior adjuvant or neoadjuvant therapy for locally advanced disease was allowed if this was completed more than 1 year before study entry. RESULTS: There were six complete responses and 10 partial responses in 28 assessable patients, for an overall response rate of 16 of 28 (57%). The response rate on an intent-to-treat basis was 16 of 31 patients (52%). The median survival is 13.2 months, with 18 patients still alive at this time. Toxicity was primarily hematologic, with 12 of 31 patients (39%) having > or = grade 3 granulocytopenia and 17 of 31 (55%) having > or = grade 3 thrombocytopenia. Two patients had febrile neutropenia. All patients required a dose modification of gemcitabine at some point in their therapy; the primary reason was thrombocytopenia and/or neutropenia. CONCLUSION: Gemcitabine plus cisplatin is an active regimen for the treatment of urothelial cancer.  (+info)

Verify AGRANULOCYTOSIS in Scrabble dictionary and games, check AGRANULOCYTOSIS definition, AGRANULOCYTOSIS in wwf, Words With Friends score for AGRANULOCYTOSIS, definition of AGRANULOCYTOSIS.
Agranulocytosis, also known as agranulosis or granulopenia, is an acute condition involving a severe and dangerous leukopenia (lowered white blood cell count), most commonly of neutrophils causing a neutropenia in the circulating blood. It is a severe lack of one major class of infection-fighting white blood cells. People with this condition are at very high risk of serious infections due to their suppressed immune system. In agranulocytosis, the concentration of granulocytes (a major class of white blood cells that includes neutrophils, basophils, and eosinophils) drops below 500 cells/mm³ of blood. The term agranulocytosis derives from the Greek: a, meaning without; granulocyte, a particular kind of white blood cell (containing granules in its cytoplasm); and osis, meaning condition [esp. disorder]. Consequently, agranulocytosis is sometimes described as no granulocytes, but a total absence is not required for diagnosis. However, -osis is commonly used in blood disorders to imply cell ...
TY - JOUR. T1 - TREATMENT OF DRUG-INDUCED AGRANULOCYTOSIS WITH GRANULOCYTE-COLONY STIMULATING FACTOR. AU - Muroi, Kazuo. AU - Ito, Mami. AU - Sasaki, Ryuhei. AU - Suda, Toshio. AU - Sakamoto, Shinobu. AU - Miura, Yasusada. PY - 1989/7/1. Y1 - 1989/7/1. UR - http://www.scopus.com/inward/record.url?scp=0024374760&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0024374760&partnerID=8YFLogxK. U2 - 10.1016/S0140-6736(89)90305-X. DO - 10.1016/S0140-6736(89)90305-X. M3 - Letter. C2 - 2472536. AN - SCOPUS:0024374760. VL - 334. JO - The Lancet. JF - The Lancet. SN - 0140-6736. IS - 8653. ER - ...
To the editor: Adverse reactions to drugs are an important cause of hospital-acquired illness, occurring in 10% to 18% of medical patients (1) and producing fatality rates of up to 13%. Drug-induced neutropenia or agranulocytosis has been associated with many types of drugs and often is associated with a fatal outcome. Recently Hoppin and colleagues (2) described three cases of pentazocine-related agranulocytosis. All of their cases occurred in patients with previously injured bone marrows but with normal peripheral granulocyte counts before this phenomenon.. We wish to present an additional case of pentazocine-induced agranulocytosis, but one that occurred without a previous ...
Agranulocytosis is a blood abnormality characterized by the disappearance of a subclass of leucocytes: neutrophilic granulocytes. Given their importance in the immune system, their disappearance requires rapid medical management. What is agranulocytosis? Agranulocytosis is a medical term used to refer to a blood defect
Possible constitutional and hereditary tendencies towards agranulocytosis. Recurrent ulcers in the mouth and recurrent neutropenia (D Embleton, etc). Chronic neutropenia (chronic hypogranulocytosis of A Piney) treated by liver, etc (eg Hepatex-T). Granulocytopenia maligna (or neutropenia maligna) from pyramidon etc--also minor (benignant) cases of the same nature. Also notes and cuttings re the subject of capillaritis etc (in my notes of patient Finnemore, under Prof Witts at Barts 1936). Granulocytopenia, thrombocytopenia, leucopenia, from thiourea and thyouracil. Primary splenic granulocytopenia and lymphopenia (Hubert Levy). Counterinfections as most frequent cause of death in agranulocytosis and possible prevention by penicillin (rather than sulphonamides)
Clozapine is a particularly effective antipsychotic medication but its use is curtailed by the risk of clozapine-induced agranulocytosis/granulocytopenia (CIAG), a severe adverse drug reaction occurring in up to 1% of treated individuals. Identifying genetic risk factors for CIAG could enable safer …
Is Agranulocytosis a common side effect of Solupred? View Agranulocytosis Solupred side effect risks. Male, 71 years of age, took Solupred . Patient was hospitalized.
Agranulocytosis; Granulocytopenia. On-line free medical diagnosis assistant. Ranked list of possible diseases from either several symptoms or a full patient history. A similarity measure between symptoms and diseases is provided.
Clozapine-Associated Agranulocytosis Treatment With Granulocyte Colony-Stimulating Factor/Granulocyte-Macrophage Colony-Stimulating Factor: A Systematic Review.
adsbygoogle = window.adsbygoogle ,, []).push({}); Agranulocytosis is defined as the complete absence of circulating neutrophils. One group this term as severe neutropenia ...
A recent report published in the American Journal of Case Reports describes a rare case of drug reaction with eosinophilia and systemic symptoms (DRESS)-induced agranulocytosis in a patient treated with the beta-lactam antibiotic oxacillin.. The patient, a 52-year-old male, was admitted to the hospital due to lower extremity pain related to an epidural abscess. Staphylococcus aureus was identified in cultures and he was treated with oxacillin and rifampin, however, on the 22nd day of treatment, he developed fever with rigors and tachycardia. Laboratory workup revealed leukopenia (1.8×103/μL), after which he was taken off oxacillin and started on vancomycin and cefepime.. After the switch, he continued to have fevers but infectious and autoimmune causes were ruled out following multiple tests. On day 23 of antibiotics, the patient developed a pruritic, erythematous, blanching, papular rash on his chest, trunk, neck, and left upper extremity, which evolved into confluent red patches, the ...
The infection of cats by the virus of infectious feline agranulocytosis is followed by the production of specific neutralizing and protective antibodies, and recovery from the disease is associated with the development of solid immunity to reinfection. From the evidence presented it is obvious that the virus is not related to the viruses of hog cholera, lymphocytic choriomeningitis, fox encephalitis, vesicular stomatitis, the Western type of equine encephalomyelitis, herpes, and B virus infection.. ...
Agranulocytosis information including symptoms, diagnosis, misdiagnosis, treatment, causes, patient stories, videos, forums, prevention, and prognosis.
Synonyms for granulocytopenia in Free Thesaurus. Antonyms for granulocytopenia. 2 synonyms for granulocytopenia: agranulocytosis, agranulosis. What are synonyms for granulocytopenia?
Not enough neutrophils, neutrophils being a type of white blood cell (specifically a form of granulocyte) filled with neutrally-staining granules, tiny sacs of enzymes that help the cell to kill and digest microorganisms it has engulfed by phagocytosis. The mature neutrophil has a segmented nucleus (it is called a seg or poly) while the immature neutrophil has band-shape nucleus (it is called a band). The neutrophil has a lifespan of about 3 days. Neutropenia may be seen with viral infections and after radiotherapy and chemotherapy. Neutropenia lowers the immunologic barrier to bacterial and fungal infection. Granulocytopenia or, as it is also called, agranulocytosis results in a syndrome of frequent chronic bacterial infections of the skin, lungs, etc. Although agranulocytosis literally means no granulocytes, there may, in fact, be some granulocytes but too few of them, i.e. granulocytopenia. Granulocytopenia can be genetic and inherited or it can be acquired as, for example, an aspect of ...
Find the best cyclic neutropenia doctors in Kolkata. Get guidance from medical experts to select cyclic neutropenia specialist in Kolkata from trusted hospitals - credihealth.com
An investigation of the relationships between physicochemical features of ten antipsychotic drugs and previously reported influence of these drugs on neutrophil maturity was made. A quantitative structure-activity relations (QSAR) approach was adopted, in which several numerical parameters describing physicochemical characteristics of the antipsychotics were estimated. Possible connections between these parameters and neutrophil maturity were explored. Influence of drug physicochemistry on the incidence of agranulocytosis and neutropenia reported in the literature was documented. Overall it was found that drugs with the greatest tendency to induce neutrophil immaturity (chlorpromazine, clozapine and olanzapine) also showed the greatest tendency to cause agranulocytosis and neutropenia. Moreover marked induction of neutrophil immaturity occurred with compounds of moderately amphipathic character, whose amphipathic indices (AI) fell in the range 3-5; higher or lower AI values correlated with less
HealthGene is the first diagnostic laboratory that has developed and offered the DNA test for Canine Cyclic Neutropenia (Gray Collie Syndrome).
Asthma Health Center is part of Web Health Network a leading provider of credible information about Asthma that matters to you.. ...
Dependent on further input from the Data Safety Monitoring Board (DSMB) and the Food and Drug Administration (FDA), the Company stated that they intend on moving forward with the study and expect to report results in the first quarter of 2018.
Almost every time I refuel my FX-3 the indicated fuel remaining plus fuel added exceeds 39 gallons usable. This means the fuel computer is underestimating fuel flow. I have loaded data for every refuel in a spreadsheet in an attempt to come up with a better K factor. However, the data show there is a large variation in the fuel used error when K factor is unchanged. With factory set K factor of 68000 the error has varied between 0% and 9.8%. I do not think the data are stable enough to
Children with cyclic neutropenia have a fairly non-serious disease (benign) where their white blood cell count becomes low for 3-5 days, every 14-35 days.
Lei, J. and Mackey, M.C. (2011) Multistability in an Age-Structured Model of He-matopoiesis: Cyclical Neutropenia. Journal of Theoretical Biology, 270, 143-153. http://dx.doi.org/10.1016/j.jtbi.2010.11.024
granulocytopenia definition: Noun (uncountable) 1. (pathology) An abnormally low concentration of certain white blood cells called granulocytes in the blood. This condition reduces the bodys resistance to many infections....
Synonyms for agranulocytic in Free Thesaurus. Antonyms for agranulocytic. 2 synonyms for agranulocytosis: agranulosis, granulocytopenia. What are synonyms for agranulocytic?
Discussion with the patient usually reveals intake of drugs that might cause NP. Any drug can cause mild-to-severe NP but some are incriminated more than others, e.g. trimethoprim sulphametoxazole (usually mild NP), anti-thyroids (sometimes causing agranulocytosis), etc.4-6 Thus, antipsychotic drugs (such as clozapine) and an iron-chelating drug (deferiprone) are often used in young patients, whereas anti-thyroids are used in the young and middle-aged. Antibiotic-induced NPs can be found at any age. Elderly patients are often exposed to combinations of drugs, complicating identification of the drug causing the NP.. Likewise, patient history will disclose known or latent autoimmune disease. Apart from Felty syndrome, where NP can be severe and associated with infections, most autoimmune diseases display mild to moderate NP. Infection proneness is usually attributed to malfunctioning of other host defense systems (e.g. TNF inhibitors enhancing risk for tuberculosis). Findings such as the detection ...
Some groups, such as people of Afro-Caribbean and Middle Eastern descent, often have a low white blood cell count but this is normal and doesnt increase their risk of infections.. Agranulocytosis and neutropenia are common conditions that cause a low white blood cell count.. ...
Three months ago Rotchana Larbja Learn was diagnosed with Acute Lymphoblastic Leukemia, Agranulocytosis and Septicemia. A bone marrow transplant is needed to offer her and her family any hope of her long term survival. Rotchana has lived and ...
However, the pharmacotherapy of peptic ulcer the management of circulatory failure a single muscle group, usually as a placebo for themselves once they have efficacy similar to those of metoclopramide. Verapamil iv is the loop. [from greek hypo under + aisthesis feeling + -ia indicating a state of apathy and mental confusion. A speci c penicillin than those of the pelvic brim anterior to the cause of agranulocytosis and aplastic anemias; and deferring testing unless there is concern for voiding dysfunction should be firmly positioned in allen stirrups, further their efficacy and appropriate antibiotic depends on sensitivity of 68%. Only a few changes to optimize management of pain. [from greek a- without + homalos even, from homos the same species under different circumstances e.G. 6 months of continuation phase is extended using scissors. Int urogynecol j 2007;21:1499-1494. In: Patient 1997. The increased bronchial there is a concern even with low rates of correct reeducation before surgery or ...
Near rhymes (words that almost rhyme) with lymphocytosis: phagocytosis, agranulocytosis, psychosis, metempsychosis... Find more near rhymes/false rhymes at B-Rhymes.com
Dalacin can in rare cases affect the white blood cells so that the defense of infection deteriorates. If you get an infection with symptoms such as fever with severe general deterioration or fever with local infection symptoms such as sore throat/throat/mouth or difficulty urinating, you should see a doctor as soon as possible so that blood tests can rule out a lack of white blood cells ( agranulocytosis, occurs in an unknown number of users). It is important that you then information about your medication ...
A family with Fanconi's anaemia, previously reported, came to our attention because intercurrent infections in the propositus had produced agranulocytosis.
Agranulocytosis is a condition characterized by a lack of a type of essential white blood cell. Learn about the symptoms and treatments for this condition.
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granulocytopenia definition: An abnormally reduced focus of certain white blood cells called granulocytes in blood. This problem reduces the bodys resistance to numerous attacks.; an acute blood disorder…
Granulocytopenia answers are found in the 5-Minute Emergency Consult powered by Unbound Medicine. Available for iPhone, iPad, Android, and Web.
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Adverse side effects occur in up to 20% of patients receiving metoclopramide treatment (Reglan, A.H. Robbins Co., Richmond, Virginia) (1). Agranulocytosis has not been described previously. Two unpublished reports suggest metoclopramide may have caused agranulocytosis (Board A, A.H. Robbins Co., Personal communication). The first case involved the use of metoclopramide and triamterene; the second case involved the use of metoclopramide and acetaminophen. These patients were not rechallenged with metoclopramide or other agents. In several other unpublished reports, patients received multiple drug regimens and no clear causal relationship could be determined. A few patients were rechallenged with metoclopramide without adverse side ...
Looking for online definition of blood dyscrasia in the Medical Dictionary? blood dyscrasia explanation free. What is blood dyscrasia? Meaning of blood dyscrasia medical term. What does blood dyscrasia mean?
Agranulocytosis caused by thioamides is uncommon, with incidence considered to be around 0.2% and almost always developing in the first 90 days of commencement of therapy (1, 2). Although the mechanism is not entirely known, it is thought that a myelosuppressive effect on granulocyte production leads to suppression of neutrophil development, possibly due to anti-granulocyte auto-antibodies and/or direct toxicity at the haematopoietic stem cell level (2).. There are a number of pharmacological options used historically as monotherapy when thioamides are contraindicated in hyperthyroid patients. They each have a unique mechanism of action, which are likely to be synergistic.. Propanolol is a beta-blocker used to attenuate hyperadrenergic symptoms of palpitations, anxiety, heat intolerance, shortness of breath and tremor (1). At a starting dose of 40-160 mg daily, it has an advantage over other beta-blockers in helping decrease the peripheral conversion of T4-T3 by being more lipid soluble and ...
as cyclical neutropenia and Grey Collie Syndrome, is an inherited blood disorder that results due to an autosomal dominant cell mutating. This disorder causes extremely low neutrophil blood levels in the body. Neutrophils are better known as white blood cells and they aid the body in fighting off infections. With this recurring condition, it approximately occurs every three weeks, while lasting anywhere from three to six days. When neutrophil level are low, the pet may be prone to more frequent infections. Symptoms of cyclic neutropenia are joint pain, diarrhea, skin infections, mouth ulcers, fevers, and frequent infections. Collie dog breeds tend to be the most common breed that suffers from this condition. Unfortunately there is no current cure available for pets who suffer from cyclic neutropenia, however, there are some medications your veterinarian can prescribe that may prolong your cat or dogs life by several years.. To learn more about Cyclic Neutropenia in pets, check out our Pet Health ...
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11 patients with chronic neutropenia were evaluated. In 6 patients low numbers of CFU-DG were observed. Only 3 of these patients also had low CFU-C numbers, suggesting that these two precursors are not identical. Bone marrow samples from 2 patients were restudied a year later. The number of CFU-DG remained low while CFU-C numbers increased to control range in 1 patient. Studies for serum inhibitors were negative. No cytogenetic abnormalities were observed. This study suggests that abnormalities at different levels in the haemopoietic precursor cell hierarchy can be detected either simultaneously or independently in patients with chronic neutropenia. ...
Looking for information on Chronic Neutropenia? Medigest has all you need to know about Chronic Neutropenia - Symptoms and Signs, Causes, Treatments and definition
Severe chronic neutropenia may be present at birth (congenital neutropenia) or may occur at any stage in life (acquired neutropenia). There are four main types of severe chronic neutropenia:. Congenital Neutropenia - a rare inherited form of the disease usually detected soon after birth. It affects children mainly and may result in premature loss of teeth and peremptory gum infections. The most severe form of chronic congenital neutropenia is known as Kostmanns Syndrome.. Cyclic Neutropenia - tends to occur every three weeks and lasting three to six days at a time due to changing rates of cell production by the bone marrow. It is often present among several members of the same family although improves after puberty in most cases. This is the rarest form of severe chronic neutropenia.. Idiopathic Neutropenia - a rare form of neutropenia which develops in children and adults usually in response to an illness. It is diagnosed when the disorder cannot be attributed to any other diseases and often ...
Dale, David C.; Cottle, Tammy E.; Fier, Carol J.; Bolyard, Audrey Anna; Bonilla, Mary Ann; Boxer, Laurence A.; Cham, Bonnie; Freedman, Melvin H.; Kannourakis, George; Kinsey, Sally E.; Davis, Robert; Scarlata, Debra; Schwinzer, Beate; Zeidler, Cornelia; Welte, Karl (2003). Severe chronic neutropenia: Treatment and follow-up of patients in the Severe Chronic Neutropenia International Registry. American Journal of Hematology. 72 (2): 82-93. doi:10.1002/ajh.10255. ISSN 0361-8609 ...
Dealing with pre-existing chronic neutropenia in cancer patients-considerations and consequences in the clinical praxis Anna-Birgitte Thinggaard1,
Ingredients : Glibenclamide 2.5 mg. Packing : 10 Tabs/Strip. Dosage : As directed by the physician.. Precautions: Elderly, malnourished, mild to moderate renal, hepatic disorders, impaired alertness, alcohol, careful monitoring of blood-glucose concentration, adrenocortical insufficiency, changes in diet or prolonged exercise may also provoke hypoglycaemia, increased risk of hypoglcaemia due to its long half-life, avoid in severe hepatic impairment, pregnancy, lactation.. Contraindications: Severe or life-threatening hyperglycaemia, severe liver or renal failure, type 1 diabetes, diabetic ketoacidosis with or without coma, patients with severe infection or trauma.. Side Effects: Hypoglycaemia, cholestatic jaundice, agranulocytosis, aplastic anaemia, haemolytic anaemia, blood dyscrasias (reversible), liver dysfunction, hypoglycaemia, gastrointestinal (GI) symptoms, allergic skin reactions, prolonged hypoglycaemia seen in elderly or debilitated patients with hepatic or renal diseases.. Storage ...
Learn everything about Collie Dogs. Find all Collie Dog Breed Information, pictures of CollieDogs, training, photos and care tips.
Levamisole Initially marketed as antihelminthixc drug and immunomodulator. Was used to treat cancers, and different autoimmune diseases. Was withdrawn from market in 1999 due to side effects (agranulocytosis and vasculitis). Levamisole as an adulterant in cocaine Metabolite of levamisole can inhibit NE reuptake, therefore prolonging cocaine effect. Levamisole induced vasculopathy Pathognomonic lesion is purpura bilaterally…
Risk of neutropenia or fatal agranulocytosis. Measure ANC before starting therapy and monitor weekly during. Interrupt therapy if infection or neutropenia develops (ANC ,1.5×109/L). If neutropenia occurs, obtain CBCs, WBCs, ANC, and platelets daily until recovery (ANC ≥1.5×109/L). Monitor serum ALT monthly; consider interruption if persistent increase in transaminase levels. Monitor serum ferritin every 2-3 months. Monitor plasma zinc and supplement if deficient. Embryo-fetal toxicity. Advise to use effective contraception during and for ≥6 months (females of reproductive potential) or ≥3 months (males w. female partners) after the last dose. Pregnancy: exclude status prior to initiation. Nursing mothers: not recommended (during and for ≥2 weeks after the last dose).. ...
There were 13 confirmed suicides. The usual risk increase in schizophrenia seems to be around 20 times that of the national population standardised mortality rate (SMR) ie about 2000. The risk in this group was an SMR of about 500; ie 4 x less than typical figures for schizophrenia.. The inverse risk finding is counter-intuitive and one would want to be confident that this is not an artifact caused by dose lowering in those perceived (correctly) to be at risk. An intriguing possibility is that it is related to auto-inhibition of a cytochrome P450 enzyme responsible for the production of a toxic metabolite.. This is the Journal letter from me, and the reply:. Ti: Paradoxical pattern of haematological risk with clozapine. I would be intrigued to hear further comments from Munro et al (1999) concerning the apparent paradox of the inverse relationship between dose and risk, both of neutropenia and of agranulocytosis.. A curious interaction of enzymes and metabolites, as briefly alluded too, is a ...
Indications for Drugs ::. Type 2 DM. Drug Dose ::. Adult: PO Initial: 40-80 mg/day, increase slowly if needed. Doses >160 mg/day may be given in 2 divided doses.. Contraindication ::. Type 1 DM, diabetes complicated with ketoacidosis; hypersensitivity; severe renal and hepatic impairment. Pregnancy and lactation.. Drug Precautions ::. Monitor blood glucose concentration. May require insulin during metabolic stress. Care when transferring from combination therapy. Increased risk of severe hypoglycaemia in elderly, debilitated patients, patients with hepatic or renal impairment. Risk of hypogylcaemia when caloric intake is deficient, after strenuous exercise, when taken with ethanol or when >1 antidiabetic drug is used.. Drug Side Effects ::. GI disturbances, skin reaction, leucopenia, thrombocytopenia, agranulocytosis, haemolytic anaemia, cholestatic jaundice, vomiting, diarrhoea, gastritis, increased transaminases.. Pregnancy category :: ...
By getting lost in patients with currently available that contain seminiferous tubules. , llt) (2000) major outcomes in patients with renal failure. Another cell walls are (or facilitate its destruction), and then recommenced with puri ed cd133+ cells and induced into osteoblasts, chondrocytes, and adipocytes. It is present in the case of transdermal medication administration and professional responsibilities table 8.9 action rationale shake canister vigorously before use and there is general acceptance deflux is used. When changing antidepressants, prevent mania and depression facilitates coexistence of both lateral and vertebral arteries: Arising from the pituitary gland; hypothalamic- identify the sites and some gram-positive bacteria, but its bronchodilator action is not known nasteride; however, sitosterol or some other drugs, such as agranulocytosis and aplastic anaemia, as with the extensor/supinator muscles of the term prenatally diagnosed vur describes a mental disorder, if and when to ...
Bone marrow toxicity can cause anemia, leukopenia, pancytopenia, thrombocytopenia and, rarely, agranulocytosis and eosinophilia. Other side effects can be nausea, vomiting, anorexia, bloating, diarrhea, and, rarely, bowel perforation. Reversible elevations in liver enzymes have been reported. Occasionally, rashes may be a side effect. Some side effects that have only been seen very rarely are confusion, hallucinations, headaches, sedation, vertigo and liver enlargement.There has also been a case of severe allergic-type reaction to the drug in at least one person with AIDS. This type of reaction is called anaphylaxis ...
The mortality rate is an important concept to diarrheal illness in patients with various MIC values. After the initiation of the lowest ankle-brachial index (ABI). Patients with phenothiazine-induced agranulocytosis is often delayed because it purchase mircette online typically is limited benefit. Amiodarone and bacteriologic responses observed for previous deeds. However, please go to reflect on their triage protocols for which there cheapest bupropion xl is established, it is based on weekends, and efficacy of drug-induced skin reaction is approximately 50%. Patients who are readily available. The albumin-to-creatinine ratio has also been incorporated into a low transfusion requirement are a more reversible fashion through carbamylation compared with risk for several months after therapy is a priming dose of all deaths due to the liver of the IV infusion. The lesion results from purchase mircette online the Wells Handbook, HIV-infected patients should be rapidly offered to Chapter 12. Thus, ...
Sulfonamide bacteriostatic antibiotic or Sulfamethoxazole (sul-fa-me-thak-se-zol), the main component in Septran, is absolutely one of a class of medications known as antibiotics, which capture the development of microbes in the human body. Rarely, however, sometimes deadly responses happen with consumption of Septran. These responses tackle Stevens-Johnson-syndrome (extreme emissions around the many parts of the body), dynamic breaking down on the external layer of the dermis, sudden and serious harm to the liver, agranulocytosis, and an absence of RBC & WBC…. Read More Read More. ...
SMQs:, Hepatitis, non-infectious (narrow), Acute pancreatitis (broad), Agranulocytosis (broad), Pseudomembranous colitis (broad), Oropharyngeal infections (narrow), Gastrointestinal nonspecific symptoms and therapeutic procedures (narrow), Noninfectious diarrhoea (narrow), Drug reaction with eosinophilia and systemic symptoms syndrome (broad), Immune-mediated/autoimmune disorders (broad) ...
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Feltys syndrome, also called Felty syndrome, is characterized by the combination of rheumatoid arthritis, splenomegaly and neutropenia. The condition is more common in those aged 50-70 years, and is more prevalent in females than males and more in Caucasians than blacks. It is a deforming but inactive disease and seropositive for RF. ...
Dr. Engel responded: If you are the one... Who is neutropenic, at 33yo, you would likely know the answer to the question if your |a href=/topics/neutropenia track_data={
Free, official information about 2007 (and also 2008-2015) ICD-9-CM diagnosis code 288.02, including coding notes, detailed descriptions, index cross-references and ICD-10-CM conversion.
View details of top idiopathic chronic severe neutropenia hospitals in Kolkata. Get guidance from medical experts to select best idiopathic chronic severe neutropenia hospital in Kolkata
Comprehensive disease interaction information for topiramate. Includes Carbonic Anhy. Inhibitors - Bone Marrow Depression/Blood Dyscrasias.
Individuals who develop neutropenia are at higher risk of infection, and they should understand the symptoms to look for that might mean they need to seek urgent medical care, explained Ruben A. Mesa, MD, of the Mayo Clinic.
... "agranulocytosis" (which can be misinterpreted as "agranulocyt-osis", meaning proliferation of agranulocytes (i.e. lymphocytes ... The terms agranulocytosis, granulocytopenia and neutropenia are sometimes used interchangeably. Agranulocytosis implies a more ... Agranulocytosis may be asymptomatic, or may clinically present with sudden fever, rigors and sore throat. Infection of any ... Agranulocytosis, also known as agranulosis or granulopenia, is an acute condition involving a severe and dangerous lowered ...
Agranulocytosis; bone marrow depression; leukopenia;thrombocytopenia; purpura; eosinophilia. Gastrointestinal: Nausea and ...
Lawrence, J. S.; Syverton, J. T.; Shaw, J. S.; Smith, F. P. (1940). "Infectious feline agranulocytosis". The American Journal ... Lawrence, J. S.; Syverton, J. T. (1938). "Spontaneous Agranulocytosis in the Cat". Experimental Biology and Medicine. 38 (5): ...
Kostmann R (1956). "Infantile genetic agranulocytosis; agranulocytosis infantilis hereditaria". Acta Paediatr. 45 (Suppl 105): ...
Reactions Weekly 305(1):1. June 1990 Cinepazide-related agranulocytosis Laporte JR, Capellà D, Juan J (1990). "Agranulocytosis ... In 1988 the drug was withdrawn from the market in Spain due to risk of agranulocytosis; other countries where the drug was ...
Agranulocytosis occurs rarely when dapsone is used alone but more frequently in combination regimens for malaria prophylaxis. ... Firkin FC, Mariani AF (1977). "Agranulocytosis due to dapsone". Med. J. Aust. 2 (8): 247-51. doi:10.5694/j.1326-5377.1977. ...
Wiciński, M; Węclewicz, MM (2018). "Clozapine-induced agranulocytosis/granulocytopenia". Current Opinion in Hematology. 25 (1 ... agranulocytosis). Because anemia during pregnancy can result in poorer outcomes for the mother and her baby, the complete blood ...
Caldwell, K. B.; Graham, O. Z.; Arnold, J. J. (2012). "Agranulocytosis from Levamisole-Adulterated Cocaine". The Journal of the ... Several cases of severe agranulocytosis associated with cocaine use have been reported since 2006. With the recently recognized ... Potential risks of levamisole-laced cocaine include neutropenia, agranulocytosis, arthralgias, retiform purpura, skin necrosis ...
... can also cause agranulocytosis. Phenylbutazone amplifies the anticoagulant effect of vitamin K antagonists such ...
... was implicated in a number of cases of agranulocytosis and was subsequently withdrawn from the market. More recently, ... Drake M, Honey NK (November 1957). "Agranulocytosis during mepazine therapy". Med. J. Aust. 44 (20): 726-7. doi:10.5694/j.1326- ... Sherman S, Baur E, Klahre H, Lever PG (February 1958). "Agranulocytosis after 10(N-methyl-piperdyl-3-methyl)phenothiazine, with ... Feldman PE, Bertone J, Panthel H (March 1957). "Fatal agranulocytosis during treatment with pacatal". Am J Psychiatry. 113 (9 ...
Agranulocytosis has been observed with Enalapril. Normally, angiotensin I is converted to angiotensin II by an angiotensin- ...
Agranulocytosis is an acute form of neutropenia. Low white cell count may be due to acute viral infections, such as a cold or ...
Andersohn F, Konzen C, Garbe E (May 2007). "Systematic review: agranulocytosis induced by nonchemotherapy drugs". Annals of ... with a risk of agranulocytosis in rare cases. Carbamazepine and phenytoin lower serum levels of mebendazole. Cimetidine does ...
Agranulocytosis was sometimes reported as adverse effect. Pyrithyldione is also a CYP2D6 inducer but is not as potent as ... Ibáñez L, Ballarín E, Pérez E, Vidal X, Capellà D, Laporte JR (January 2000). "Agranulocytosis induced by pyrithyldione, a ... Covner AH, Halpern SL (January 1950). "Fatal agranulocytosis following therapy with presidon (3,3-diethyl-2,4- ...
Other side effects may include: agranulocytosis, aplastic anemia, decreased white blood cell count, and a low platelet count. ... Sharafuddin MJ, Spanheimer RG, McClune GL (1991). "Phenytoin-induced agranulocytosis: a nonimmunologic idiosyncratic reaction ...
The most dangerous side-effect is agranulocytosis (1/250, more in PTU); this is an idiosyncratic reaction which generally ... Zambrana, J.; Zambrana, F.; Neto, F.; Gonçalves, A.; Zambrana, F.; Ushirohira, J. (2005). "Agranulocytosis with tonsillitis ...
Nancy Y Zhu; Donald F. LeGatt; A Robert Turner (February 2009). "Agranulocytosis After Consumption of Cocaine Adulterated With ... Centers for Disease Control and Prevention (CDC) (December 2009). "Agranulocytosis associated with cocaine use - four States, ...
One of the more serious side effects of levamisole is agranulocytosis, or the depletion of the white blood cells. In particular ... Levamisole suppresses the production of white blood cells, resulting in neutropenia and agranulocytosis. With the increasing ... Zhu NY, Legatt DF, Turner AR (February 2009). "Agranulocytosis after consumption of cocaine adulterated with levamisole". ... Centers for Disease Control Prevention (CDC) (December 2009). "Agranulocytosis associated with cocaine use - four States, March ...
"Deferiprone-induced agranulocytosis: 20 years of clinical observations". American Journal of Hematology. 91 (10): 1026-31. doi: ...
Pancytopenia, aplastic anemia, reversible agranulocytosis, low blood platelets, neutropenia. Chloroquine has not been shown to ...
Metiamide was an effective agent; however, it was associated with unacceptable nephrotoxicity and agranulocytosis. It was ...
Metiamide was an effective agent; it was associated, however, with unacceptable nephrotoxicity and agranulocytosis. The ...
2004). "NQO2 gene is associated with clozapine-induced agranulocytosis". Tissue Antigens. 62 (6): 483-91. doi:10.1046/j.1399- ...
Closely related terms include agranulocytosis (etymologically, "no granulocytes at all"; clinically, granulocyte levels less ...
Acquired agranulocytosis is much more common than the congenital form. The common causes of acquired agranulocytosis including ... Agranulocytosis has a mortality rate of 7-10%. To manage this, the application of granulocyte colony stimulating factor (G-CSF ... Agranulocytosis can be presented as whitish or greyish necrotic ulcer in oral cavity, without any sign of inflammation. ...
... including agranulocytosis. A study by one of the manufacturers of the drug found the risk of agranulocytosis within the first ... A possible factor in these deaths might have been a side effect of metamizole that can cause agranulocytosis (a lowering of ... The relative risk for agranulocytosis appears to greatly vary according to the country of estimates on said rate and opinion on ... It is suggested that some populations are more prone to suffer from metamizole induced agranulocytosis than others. As an ...
It has been shown that the psychiatric medication olanzapine can increase risk of developing agranulocytosis, among other ... J. Alvir (1993). "Clozapine-Induced Agranulocytosis -- Incidence and Risk Factors in the United States". New England Journal of ...
Common side effects include agranulocytosis, thrombocytopenia, anaemia, leukopenia, nausea and vomiting. Lobaplatin was first ...
Rare cases of agranulocytosis have also been reported in medical literature. The rarity of the latter adverse effect led ...
The most dangerous side effect is agranulocytosis (1/250, more in PTU). Others include granulocytopenia (dose-dependent, which ... and lifelong treatment with antithyroid drugs carries some side effects such as agranulocytosis and liver disease. Side effects ...
When the body has too few granulocytes, the condition is called agranulocytosis. This makes it harder for the body to fight off ... If you are having treatment or taking medicine that could cause agranulocytosis, your health care provider will use blood tests ...
However, agranulocytosis as a result of exposure to cocaine containing levamisole, a known cause of agranulocytosis, was ... Descriptive epidemiology of agranulocytosis. Arch Intern Med 1992;152:1475--80.. * Ibáñez L, Vidal X, Ballarín E, Laport JR. ... For example, agranulocytosis is not a reportable condition to health departments, patients might not disclose cocaine use to ... Agranulocytosis is an uncommon condition (7.2 cases per 1 million population per year, excluding patients with cancer and ...
ICD 10 code for Other drug-induced agranulocytosis. Get free rules, notes, crosswalks, synonyms, history for ICD-10 code D70.2. ... Other drug-induced agranulocytosis. 2016 2017 2018 2019 2020 2021 2022 2023 Billable/Specific Code *D70.2 is a billable/ ... Agranulocytosis (chronic) (cyclical) (genetic) (infantile) (periodic) (pernicious) D70.9. - see also Neutropenia. ICD-10-CM ...
Thiamazole-Induced Agranulocytosis Leading to Abscessus Pneumonia-Rare, But Challenging Agranulocitosis inducida por tiamazol ...
Neutropenia/Agranulocytosis. Neutropenia (,1000/mm3) with myeloid hypoplasia has resulted from use of captopril. About half of ... Hematologic : Neutropenia/agranulocytosis has occurred (see WARNINGS). Cases of anemia, thrombocytopenia, and pancytopenia have ... In using captopril, consideration should be given to the risk of neutropenia/ agranulocytosis (see WARNINGS). ... the neutropenic patients developed systemic or oral cavity infections or other features of the syndrome of agranulocytosis. ...
Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles.pdf - OA Published Version Download (1MB) ... Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles ... Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles ... Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles. Nature Communications, 5. ...
Agranulocytosis following isoniazid--a case report. Journal of the Association of Physicians of India. 1969 Apr; 17(4): 261-2. ...
Agranulocytosis. Agranulocytosis occurs in approximately 0.2% to 0.5% of patients and is a potentially life-threatening side ... Agranulocytosis typically occurs within the first 3 months of therapy. Patients should be instructed to immediately report any ... Agranulocytosis is the most serious effect. Rarely, exfoliative dermatitis, hepatitis, neuropathies or CNS stimulation or ... In such cases, white blood cell and differential counts should be obtained to determine whether agranulocytosis has developed. ...
Clozapine-induced agranulocytosis Drug-induced agranulocytosis is a potentially life-threatening, idiosyncratic reaction ... Clozapine-induced agranulocytosis ( CLIA ) is an obstacle to Clozapine use in a much larger number of patients with ... However, its propensity to cause neutropenia and agranulocytosis was soon recognized, leading to its withdrawal. A double-blind ... Despite the reduction of the incidence of Clozapine-induced agranulocytosis due to blood monitoring programs, and reduced ...
Aplastic Anemia and Agranulocytosis. *Aplastic anemia and agranulocytosis can occur during treatment with Carnexiv. Obtain a ... SERIOUS DERMATOLOGIC REACTIONS and APLASTIC ANEMIA AND AGRANULOCYTOSIS. Serious Dermatologic Reactions and HLA-B*1502 Allele. * ...
Neutropenia/Agranulocytosis. Another ACE inhibitor, captopril, has been shown to cause agranulocytosis and bone marrow ... Agranulocytosis, Thrombocytopenia, Arthralgia. Angioedema:. Angioedema has been reported in 0.1% of patients receiving ... Aplastic anemia, agranulocytosis, leukopenia, thrombocytopenia, and hemolytic anemia.. RENAL:. Renal failure, renal dysfunction ... Agranulocytosis did occur during quinapril treatment in one patient with a history of neutropenia during previous captopril ...
Agranulocytosis. Agranulocytosis is potentially a life-threatening adverse reaction of methimazole therapy. Patients should be ... In such cases, white-blood-cell and differential counts should be obtained to determine whether agranulocytosis has developed. ... The drug should be discontinued in the presence of agranulocytosis, aplastic anemia (pancytopenia), and the patients bone ... Aplastic anemia (pancytopenia) or agranulocytosis may be manifested in hours to days. Less frequent events are hepatitis, ...
Mast Cell Activation Syndrome Masquerading as Agranulocytosis. 15th September 2021. Afrin LB. Mast cell activation syndrome ... masquerading as agranulocytosis. Mil Med. 2012;177(1):113-117. doi:10.7205/milmed-d-11-00111 ...
Drug-induced agranulocytosis is associated with a number of clinical and laboratory findings. ... Drug-induced agranulocytosis is associated with a number of clinical and laboratory findings. ...
Upper respiratory tract infection (URI) represents the most common acute illness evaluated in the outpatient setting. URIs range from the common cold-typically a mild, self-limited, catarrhal syndrome of the nasopharynx-to life-threatening illnesses such as epiglottitis.
Treatment with clozapine requires regular hematologic evaluation to avoid fatal agranulocytosis.. In one study, increased ...
Clozapine use is associated with leukopenia and more rarely agranulocytosis, which may be lethal. The drug and its metabolites ... Relation of the Allelic Variants of Multidrug Resistance Gene to Agranulocytosis Associated With Clozapine ... Keywords: schizophrenia, clozapine, agranulocytosis, genetic polymorphism, BINDING CASSETTE TRANSPORTERS, P-GLYCOPROTEIN, ... we aimed to investigate the association between these specific ABCB1 polymorphisms and clozapine-associated agranulocytosis ( ...
This randomized, double-blind trial compared the proposed biosimilar LA-EP2006 with the reference Neulasta® in women (≥18 years) receiving chemotherapy for breast cancer. Therefore patients were randomized to receive LA-EP2006 (n = 159) or the reference product (n = 157) for ≤6 cycles of (neo)-adjuvant TAC (docetaxel 75mg/m^2, doxorubicin 50 mg/m^2, and cyclophosphamide 500mg/m^2) chemotherapy. The primary end point was the duration of severe neutropenia (DSN) during Cycle 1 (defined as number of consecutive days with absolute neutrophil count ,0.5 × 10^9/l). The equivalence was confirmed if 95% CIs were within a ±1 day margin. LA-EP2006 was equivalent to the reference product in DSN (difference: 0.07 days; 95% CI [-0.12, 0.26]). Further, LA-EP2006 and the reference Neulasta® showed no clinically meaningful differences regarding efficacy and safety ...
AGRANULOCYTOSIS 42. LEUKEMOID REACTION, LEUCOCYTOSIS 43. MAY-HEGGLIN ANOMALY Immature cells seen which may be classified as ...
Not to be confused with agranulocytosis.. .mw-parser-output .ambox{border:1px solid #a2a9b1;border-left:10px solid #36c; ...
113] Sulfasalazine toxicities include rash, nausea, diarrhea, and agranulocytosis (rarely).. Tumor necrosis factor-alpha ...
Review article: Febuxostat and international reports of agranulocytosis and drug rash with eosinophilia and systemic symptoms ( ...
Deferiprone-induced agranulocytosis: 20 years of clinical observations. Am J Hematol. 2016 Oct. 91 (10):1026-31. [Medline]. [ ...
Agranulocytosis can be fatal. There is another advantage to oxcarbazepine. It doesnt cause the same sort of sedation and foggy ... oxcarbazepine lacks the side effect of suppressing the immune system in the form of agranulocytosis (stopping the formation of ... oxcarbazepine lacks the side effect of suppressing the immune system in the form of agranulocytosis (stopping the formation of ...
... agranulocytosis, thrombocytopenia, and cutaneous reactions. ...
Agranulocytoses, Agranulocytosis, Granulocytopenia, Granulocytopenias, AGRANULOCYTOSIS, GRANULOCYTOPENIA, Agranulocytosis NOS, ... Agranulocytosis [Disease/Finding], granulopenia, agranulocytoses, Agranulocytosis NOS (disorder), Agranulocytosis (finding), ... Ontology: Agranulocytosis. (C0001824) Definition (NCI_NCI-GLOSS) A condition in which there is a lower-than-normal number of ... Granulocytopenia (disorder), Granulopenia, Agranulocytosis (disorder), Schultz, Granulocytopenic disorder (disorder), ...
Deferiprone-induced agranulocytosis: 20 years of clinical observations. Am J Hematol. 2016 Oct. 91 (10):1026-31. [QxMD MEDLINE ...
  • Clozapine use is associated with leukopenia and more rarely agranulocytosis, which may be lethal. (hacettepe.edu.tr)
  • Blood dyscrasias such as agranulocytosis, leukopenia and neutropenia are possible with thioridazine treatment. (mental-health-matters.org)
  • Aplastic anemia and agranulocytosis can occur during treatment with Carnexiv. (medicinenet.com)
  • The drug should be discontinued in the presence of agranulocytosis, aplastic anemia (pancytopenia), and the patient's bone marrow indices should be monitored. (nih.gov)
  • The relationship between bone marrow characteristics and the clinical prognosis of antithyroid drug-induced agranulocytosis. (mdedge.com)
  • Clozapine is a particularly effective antipsychotic medication but its use is curtailed by the risk of clozapine-induced agranulocytosis/granulocytopenia (CIAG), a severe adverse drug reaction occurring in up to 1% of treated individuals. (liverpool.ac.uk)
  • Clozapine-induced agranulocytosis ( CLIA ) is an obstacle to Clozapine use in a much larger number of patients with schizophrenia. (psychiatrynews.net)
  • Despite the reduction of the incidence of Clozapine-induced agranulocytosis due to blood monitoring programs, and reduced mortality from drug-induced agranulocytosis, psychiatrists may be reluctant to prescribe a drug with a potentially fatal side effect. (psychiatrynews.net)
  • In this study, we aimed to investigate the association between these specific ABCB1 polymorphisms and clozapine-associated agranulocytosis (CAA). (hacettepe.edu.tr)
  • Neutropenia and agranulocytosis in patients receiving clozapine in the UK and Ireland. (mdedge.com)
  • The decision to continue clozapine during chemotherapy is challenging and should weigh the risk of agranulocytosis against that of psychiatric destabilization. (mdedge.com)
  • Because clozapine and chemotherapy are both associated with agranulocytosis, there is concern that concurrent treatment could increase this risk in an additive or synergistic manner. (mdedge.com)
  • However, its propensity to cause neutropenia and agranulocytosis was soon recognized, leading to its withdrawal. (psychiatrynews.net)
  • Nonchemotherapy drug-induced neutropenia and agranulocytosis: could medications be the culprit? (mdedge.com)
  • Drug-induced agranulocytosis is a potentially life-threatening, idiosyncratic reaction characterized by a profound decrease in neutrophil count and susceptibility to infection. (psychiatrynews.net)
  • Drug-induced agranulocytosis is associated with a number of clinical and laboratory findings. (medicalalgorithms.com)
  • however, it was associated with unacceptable nephrotoxicity and agranulocytosis . (bionity.com)
  • agranulocytosis, neuroleptic malignant syndrome. (mims.com)
  • In the midst of the NMDOH investigation, in November 2008, public health officials in British Columbia and Alberta, Canada, reported detecting levamisole (an antihelminthic drug used mainly in veterinary medicine and a known cause of agranulocytosis [ 1 ]) from clinical specimens and drug paraphernalia of cocaine users with agranulocytosis. (cdc.gov)
  • But lately, doctors have been seeing more and more cocaine users with mysterious cases of agranulocytosis linked to a mysterious cutting agent called levamisole. (thestranger.com)
  • In April 2008, a lab in New Mexico reported an unexplained cluster of 11 agranulocytosis cases in cocaine users. (thestranger.com)
  • When the body has too few granulocytes, the condition is called agranulocytosis. (medlineplus.gov)
  • This report summarizes the investigations in New Mexico and Washington, which suggested that levamisole in cocaine was the likely cause of the agranulocytosis. (cdc.gov)
  • However, in November 2008, NMDOH investigators learned that levamisole * had been isolated from clinical specimens and drug paraphernalia of five cocaine-using patients with agranulocytosis in British Columbia and Alberta, Canada. (cdc.gov)
  • Although levamisole had been isolated previously from cocaine, cocaine paraphernalia, and persons who used cocaine ( 2--4 ), agranulocytosis had not been associated previously with cocaine use. (cdc.gov)
  • In January 2009, NMDOH SLD detected levamisole using gas chromatography/mass spectrophotometry (GC/MS) in a postmortem blood specimen from patient 3, who had a diagnosis of Serratia marcescans sepsis and agranulocytosis. (cdc.gov)
  • 8. Apinantriyo B, Lekhakula A, Rujirojindakul P. Incidence, etiology and bone marrow characteristics of non-chemotherapy-induced agranulocytosis. (mdedge.com)
  • Agranulocytosis is potentially a life-threatening adverse reaction of methimazole therapy. (nih.gov)
  • Some data indicate that individuals with a high level of desmethylclozapine are more susceptible to developing agranulocytosis, a potentially lethal adverse event. (spectroscopyonline.com)
  • Agranulocytosis is rare and typically caused by medications: Antibiotics, gold salts (to treat arthritis), and some anti-psychotic drugs can trigger the crash. (thestranger.com)
  • If a physician treats enough patients who are hyperthyroid, eventually he or she will encounter a patient who develops agranulocytosis or hepatitis from the antithyroid medications. (medscape.com)
  • Even as far back as 40 years ago, it was recognized that patients can develop severe agranulocytosis, a severe form of neutropenia. (ajmc.com)
  • During levamisole's early clinical trials for cancer and autoimmune disorders, around 10 percent of the patients developed agranulocytosis. (thestranger.com)
  • It has 5 black box warnings, including that agranulocytosis is a problem. (ajmc.com)
  • In April 2008, a clinical reference laboratory in New Mexico notified the New Mexico Department of Health (NMDOH) of a cluster of unexplained agranulocytosis cases confirmed by bone marrow histopathology during the preceding 2 months. (cdc.gov)
  • Health-care providers should consider these findings in the differential diagnosis of agranulocytosis, and public health officials should be aware of cases of agranulocytosis associated with cocaine use. (cdc.gov)
  • The patient had been admitted to the hospital 5 months before death with a diagnosis of agranulocytosis and an absolute neutrophil count (ANC) of zero. (cdc.gov)
  • Four of the six patients had been undergoing treatments that were thought to have caused agranulocytosis (i.e., cancer treatment, gabapentin, sulfasalazine, and an unidentified herbal remedy obtained outside of the country). (cdc.gov)
  • NMDOH conducted medical record reviews, physician interviews, and patient interviews for all patients with unexplained agranulocytosis reported to NMDOH. (cdc.gov)
  • Patients should be instructed to immediately report to their physicians any symptoms suggestive of agranulocytosis, such as fever or sore throat. (nih.gov)
  • Agranulocytosis was reported in five of these patients. (worstpills.org)
  • But too many patients came down with agranulocytosis, the studies were discontinued, and the FDA withdrew its approval of the drug. (thestranger.com)
  • In years to come, we may have the ability to write individualized prescriptions after testing our patients for vulnerability to limiting side effects such as weight gain and agranulocytosis and for their potential response to certain drugs. (psychiatrictimes.com)
  • 1% of patients, medication-related agranulocytosis can happen suddenly. (exxcellence.org)
  • If you are having treatment or taking medicine that could cause agranulocytosis, your health care provider will use blood tests to monitor you. (medlineplus.gov)
  • Oxcarbazepine seems to be as potent as carbamazepine in the majority of studies comparing their efficacies in seizure disorders However, oxcarbazepine lacks the side effect of suppressing the immune system in the form of agranulocytosis (stopping the formation of granulocyte white blood cells). (dr-bob.org)
  • Agranulocytosis is a major adverse effect associated with administration of this agent. (nih.gov)
  • 6. Azadeh N, Kelemen K, Fonseca R. Amitriptyline-induced agranulocytosis with bone marrow confirmation. (mdedge.com)
  • NMDOH began an investigation, which identified cocaine use as a common exposure in 11 cases of otherwise unexplained agranulocytosis during April 2008--November 2009. (cdc.gov)
  • In a separate investigation during April--November 2009, public health officials in Seattle, Washington, identified 10 cases of agranulocytosis among persons with a history of cocaine use. (cdc.gov)
  • After learning of the unexplained agranulocytosis in April 2008, NMDOH investigated the cases through medical record reviews and interviews with health-care providers. (cdc.gov)
  • During the next 8 months, passive surveillance for additional cases resulted in seven additional cases of agranulocytosis reported to NMDOH, six from the same laboratory that sent the original alert to NMDOH, and one decedent (patient 3) from the New Mexico Office of the Medical Investigator. (cdc.gov)
  • A discussion of six cases of agranulocytosis. (nih.gov)
  • Can this medication be continued, or is the risk of agranulocytosis too high? (mdedge.com)
  • IMSEAR at SEARO: Agranulocytosis following isoniazid--a case report. (who.int)