Antithyroid Agents
Methimazole
Levamisole
An antihelminthic drug that has been tried experimentally in rheumatic disorders where it apparently restores the immune response by increasing macrophage chemotaxis and T-lymphocyte function. Paradoxically, this immune enhancement appears to be beneficial in rheumatoid arthritis where dermatitis, leukopenia, and thrombocytopenia, and nausea and vomiting have been reported as side effects. (From Smith and Reynard, Textbook of Pharmacology, 1991, p435-6)
Clozapine
A tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a major adverse effect associated with administration of this agent.
Drug Contamination
Propylthiouracil
Veterinary Drugs
Drugs used by veterinarians in the treatment of animal diseases. The veterinarian's pharmacological armamentarium is the counterpart of drugs treating human diseases, with dosage and administration adjusted to the size, weight, disease, and idiosyncrasies of the species. In the United States most drugs are subject to federal regulations with special reference to the safety of drugs and residues in edible animal products.
Phenylbutazone
Chlorpropamide
Graves Disease
A common form of hyperthyroidism with a diffuse hyperplastic GOITER. It is an autoimmune disorder that produces antibodies against the THYROID STIMULATING HORMONE RECEPTOR. These autoantibodies activate the TSH receptor, thereby stimulating the THYROID GLAND and hypersecretion of THYROID HORMONES. These autoantibodies can also affect the eyes (GRAVES OPHTHALMOPATHY) and the skin (Graves dermopathy).
HLA-B38 Antigen
Antinematodal Agents
Acecainide
Dipyrone
Hypochlorous Acid
Meprobamate
A carbamate with hypnotic, sedative, and some muscle relaxant properties, although in therapeutic doses reduction of anxiety rather than a direct effect may be responsible for muscle relaxation. Meprobamate has been reported to have anticonvulsant actions against petit mal seizures, but not against grand mal seizures (which may be exacerbated). It is used in the treatment of ANXIETY DISORDERS, and also for the short-term management of INSOMNIA but has largely been superseded by the BENZODIAZEPINES. (From Martindale, The Extra Pharmacopoeia, 30th ed, p603)
Anemia, Aplastic
United States Public Health Service
Pancytopenia
Chlorpromazine
The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking DOPAMINE RECEPTORS. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.
Drug-Related Side Effects and Adverse Reactions
Bone Marrow
The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.
Granulocyte Colony-Stimulating Factor
A glycoprotein of MW 25 kDa containing internal disulfide bonds. It induces the survival, proliferation, and differentiation of neutrophilic granulocyte precursor cells and functionally activates mature blood neutrophils. Among the family of colony-stimulating factors, G-CSF is the most potent inducer of terminal differentiation to granulocytes and macrophages of leukemic myeloid cell lines.
Antipsychotic Agents
Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus.
Hyperthyroidism
Drug Monitoring
Peroxidase
Leukocyte Count
Cocaine
An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat. It also has powerful central nervous system effects similar to the amphetamines and is a drug of abuse. Cocaine, like amphetamines, acts by multiple mechanisms on brain catecholaminergic neurons; the mechanism of its reinforcing effects is thought to involve inhibition of dopamine uptake.
Canada
Health Promotion
Drug Approval
Midwestern United States
The geographic area of the midwestern region of the United States in general or when the specific state or states are not indicated. The states usually included in this region are Illinois, Indiana, Iowa, Kansas, Kentucky, Michigan, Minnesota, Missouri, Nebraska, Ohio, Oklahoma, North Dakota, South Dakota and Wisconsin.
Phase I trial of dolastatin-10 (NSC 376128) in patients with advanced solid tumors. (1/458)
Dolastatin-10 (dola-10) is a potent antimitotic peptide, isolated from the marine mollusk Dolabela auricularia, that inhibits tubulin polymerization. Preclinical studies of dola-10 have demonstrated activity against a variety of murine and human tumors in cell cultures and mice models. The purpose of this Phase I clinical trial was to characterize the maximum tolerated dose, pharmacokinetics, and biological effects of dola-10 in patients with advanced solid tumors. Escalating doses of dola-10 were administered as an i.v. bolus every 21 days, using a modified Fibonacci dose escalation schema. Pharmacokinetic studies were performed with the first treatment cycle. Neurological testing was performed on each patient prior to treatment with dola-10, at 6 weeks and at study termination. Thirty eligible patients received a total of 94 cycles (median, 2 cycles; maximum, 14 cycles) of dola-10 at doses ranging from 65 to 455 microg/m2. Dose-limiting toxicity of granulocytopenia was seen at 455 microg/m2 for minimally pretreated patients (two or fewer prior chemotherapy regimens) and 325 microg/m2 for heavily pretreated patients (more than two prior chemotherapy regimens). Nonhematological toxicity was generally mild. Local irritation at the drug injection site was mild and not dose dependent. Nine patients developed new or increased symptoms of mild peripheral sensory neuropathy that was not dose limiting. This toxicity was more frequent in patients with preexisting peripheral neuropathies. Pharmacokinetic studies demonstrated a rapid drug distribution with a prolonged plasma elimination phase (t 1/2z = 320 min). The area under the concentration-time curve increased in proportion to administered dose, whereas the clearance remained constant over the doses studied. Correlation analysis demonstrated a strong relationship between dola-10 area under the concentration-time curve values and decrease from baseline for leukocyte counts. In conclusion, dola-10 administered every 3 weeks as a peripheral i.v. bolus is well tolerated with dose-limiting toxicity of granulocytopenia. The maximum tolerated dose (and recommended Phase II starting dose) is 400 microg/m2 for patients with minimal prior treatment (two or fewer prior chemotherapy regimens) and 325 microg/m2 for patients who are heavily pretreated (more than two prior chemotherapy regimens). (+info)Agranulocytosis in Bangkok, Thailand: a predominantly drug-induced disease with an unusually low incidence. Aplastic Anemia Study Group. (2/458)
Agranulocytosis, a syndrome characterized by a marked reduction in circulating granulocytes, is strongly associated with medical drug use in Europe and the United States. Unregulated use of common pharmaceutical agents in developing countries has been suspected of causing large numbers of cases of agranulocytosis and deaths, especially among children. To elucidate the incidence and etiology of agranulocytosis in Thailand, a population-based case-control study of symptomatic agranulocytosis that resulted in hospital admission was conducted in Bangkok from 1990 to 1994. An attempt was also made to study the disease in Khonkaen (in northeastern Thailand) and Songkla (in southern Thailand), but there were insufficient cases in the latter regions, and the analysis was confined to subjects from Bangkok. In that region, the overall incidence of agranulocytosis was 0.8 per million per year; there were no deaths. As expected, the incidence was higher in females (0.9 per million), and it increased with age (4.3 per million beyond age 60). Among 25 cases and 529 controls the relative risk estimate for a combined category of all suspect drugs was 9.2 (95% confidence interval = 3.9-21), and the proportion of cases that could be attributed to drug use was 68%. For individual drugs and drug classes the data were sparse; within these limitations, the strongest association appeared to be with antithyroid drugs. One case and three controls were exposed to dipyrone, a drug known to cause agranulocytosis; with such scanty data the risk could not be evaluated. Exposure to pesticides or solvents was not associated with an increased risk. This is the first formal epidemiologic study of agranulocytosis in a developing country. As in the West, most cases are attributable to medical drug use. However, the incidence of agranulocytosis in Bangkok, and apparently, in Thailand as a whole, is unusually low, and the disease does not pose a public health risk. (+info)Phase I study of a biweekly schedule of a fixed dose of cisplatin with increasing doses of paclitaxel in patients with advanced oesophageal cancer. (3/458)
We performed this dose-finding study with a fixed dose of cisplatin and increasing doses of paclitaxel given every 2 weeks to determine the maximum tolerable dose of this schedule. Sixty-four patients with advanced oesophageal cancer were treated with a cisplatin dose of 60 mg m(-2) and increasing doses of paclitaxel from 100 mg m(-2) up to 200 mg m(-2) both administered over 3 h for a maximum of six cycles in patients with stable disease or eight cycles in responding patients. Patients were retreated when the granulocytes were > 0.75 x 10(9) l(-1) and the platelets > 75 x 10(9) l(-1). The dose of paclitaxel could be increased to 200 mg m(-2) without encountering dose limiting haematological toxicity. At the dose levels 190 mg m(-2) and 200 mg m(-2) of paclitaxel cumulative sensory neurotoxicity became the dose-limiting toxicity. The dose intensity of paclitaxel calculated over six cycles rose from 50 mg m(-2) per week to 85 mg m(-2) per week. Only three episodes of granulocytopenic fever were encountered out of a total of 362 cycles of treatment. Of the 59 patients evaluable for response, 31 (52%) had a partial or complete response. In a biweekly schedule with a fixed dose of 60 mg m(-2) cisplatin it is possible to increase the dose of paclitaxel to 180 mg m(-2). At higher dose levels, neurotoxicity becomes the dose-limiting toxicity. The observed response rate warrants further investigation of this schedule. (+info)Oral versus intravenous empirical antimicrobial therapy for fever in patients with granulocytopenia who are receiving cancer chemotherapy. International Antimicrobial Therapy Cooperative Group of the European Organization for Research and Treatment of Cancer. (4/458)
BACKGROUND: Intravenously administered antimicrobial agents have been the standard choice for the empirical management of fever in patients with cancer and granulocytopenia. If orally administered empirical therapy is as effective as intravenous therapy, it would offer advantages such as improved quality of life and lower cost. METHODS: In a prospective, open-label, multicenter trial, we randomly assigned febrile patients with cancer who had granulocytopenia that was expected to resolve within 10 days to receive empirical therapy with either oral ciprofloxacin (750 mg twice daily) plus amoxicillin-clavulanate (625 mg three times daily) or standard daily doses of intravenous ceftriaxone plus amikacin. All patients were hospitalized until their fever resolved. The primary objective of the study was to determine whether there was equivalence between the regimens, defined as an absolute difference in the rates of success of 10 percent or less. RESULTS: Equivalence was demonstrated at the second interim analysis, and the trial was terminated after the enrollment of 353 patients. In the analysis of the 312 patients who were treated according to the protocol and who could be evaluated, treatment was successful in 86 percent of the patients in the oral-therapy group (95 percent confidence interval, 80 to 91 percent) and 84 percent of those in the intravenous-therapy group (95 percent confidence interval, 78 to 90 percent; P=0.02). The results were similar in the intention-to-treat analysis (80 percent and 77 percent, respectively; P=0.03), as were the duration of fever, the time to a change in the regimen, the reasons for such a change, the duration of therapy, and survival. The types of adverse events differed slightly between the groups but were similar in frequency. CONCLUSIONS: In low-risk patients with cancer who have fever and granulocytopenia, oral therapy with ciprofloxacin plus amoxicillin-clavulanate is as effective as intravenous therapy. (+info)Murine neutrophil stimulation by Toxoplasma gondii antigen drives high level production of IFN-gamma-independent IL-12. (5/458)
Successful immunity to Toxoplasma gondii requires a strong cell-mediated immune response. Neutrophils possess the ability to rapidly migrate into tissues in response to microbial stimuli. Therefore, we sought to determine whether murine neutrophils could respond to T. gondii by producing immunoregulatory cytokines. We show that murine neutrophils produce high levels of IL-12 and low, but significant, levels of TNF-alpha when stimulated with T. gondii Ag. Both cytokines are produced in the absence of IFN-gamma. Production of IL-12 does not require TNFR p55, and release of TNF-alpha occurs independently of IL-12. We show that there is an influx of neutrophils into the peritoneal cavity that peaks at approximately 8 h in response to injection of live tachyzoites and that this is correlated with increased transcription of IL-12 p40. Our results establish that murine neutrophils possess the ability to produce immunoregulatory cytokines during T. gondii infection and suggest that this response may be important in early host defense and in triggering cell-mediated immunity to the parasite. (+info)Different effect of granulocyte colony-stimulating factor or bacterial infection on bone-marrow cells of cyclophosphamide-treated or irradiated mice. (6/458)
In the present study, the effect of treatment with granulocyte colony-stimulating factor (G-CSF) on cellular composition of the bone marrow and the number of circulating leucocytes of granulocytopenic mice, whether or not infected with Staphylococcus aureus, was assessed. With two monoclonal antibodies, six morphologically distinct cell populations in the bone marrow could be characterised and quantitated by two-dimensional flow cytometry. Granulocytopenia was induced by cyclophosphamide or sublethal irradiation. Cyclophosphamide predominantly affected the later stages of dividing cells in the bone marrow resulting in a decrease in number of granulocytic cells, monocytic cells, lymphoid cells and myeloid blasts. G-CSF administration to cyclophosphamide-treated mice increased the number of early blasts, myeloid blasts and granulocytic cells in the bone marrow, which indicates that this growth factor stimulates the proliferation of these cells in the bone marrow. During infection in cyclophosphamide-treated mice the number of myeloid blasts increased. However, when an infection was induced in cyclophosphamide and G-CSF-treated mice, the proliferation of bone-marrow cells was not changed compared to that in noninfected similarly treated mice. Sublethal irradiation affected all bone-marrow cell populations, including the early blasts. G-CSF-treatment of irradiated mice increased only the number of myeloid blasts slightly, whereas an infection in irradiated mice, whether or not treated with G-CSF, did not affect the number of bone-marrow cells. Together, these studies demonstrated that irradiation affects the early blasts and myeloid blasts in the bone marrow more severely than treatment with cyclophosphamide. Irradiation probably depletes the bone marrow from G-CSF-responsive cells, while cyclophosphamide spared G-CSF responsive cells, thus enabling the enhanced G-CSF-mediated recovery after cyclophosphamide treatment. Only in these mice, bone marrow recovery is followed by a strong mobilisation of mature granulocytes and their band forms from the bone marrow into the circulation during a bacterial infection. (+info)Fludarabine-based chemotherapy in untreated mantle cell lymphomas: an encouraging experience in 29 patients. (7/458)
BACKGROUND AND OBJECTIVE: A prospective study to evaluate the role of fludarabine alone or in combination with idarubicin in untreated patients with mantle cell lymphoma (MCL). DESIGN AND METHODS: Twenty-nine untreated patients with mantle cell lymphoma were stochastically treated with intravenous fludarabine at a dose of 25 mg/m(2)/day for 5 days (11 patients) or with a combination of fludarabine and idarubicin (FLU-ID) (fludarabine 25 mg/m(2) i.v. on days 1 to 3 and idarubicin 12 mg/m(2) i.v. on day 1 (18 patients). For both regimens, cycles were given at three-week intervals for a total of six courses. According to the International Prognostic Index, the most part of high-intermediate and high risk factor patients were in the FLU-ID subset: 7 (39%) patients vs. 2 (18%) in the fludarabine alone subset. RESULTS: Of the 29 patients, 8 (28%) obtained a complete response and 10 (35%) a partial response, with an overall response rate of 63%. The remaining 11 (37%) patients did not respond to the therapy. The overall response rates were 64% (7 patients) in the fludarabine group and 61% (11 patients) in the FLU-ID group. The complete response rate was 27% (3 patients) for fludarabine and 28% (5 patients) for FLU-ID. The toxicity was mild in terms of neutropenia and infections, and no fatalities occurred due to drug-induced side effects. INTERPRETATION AND CONCLUSIONS: These results suggest the efficacy of fludarabine alone or in combination with idarubicin in MCL patients. It will be important to increase this experience and to assess other fludarabine-containing regimens, in particular with cyclophosphamide plus idarubicin and with mitoxantrone and or cyclophosphamide, to test the true role of this approach in MCL. (+info)Gemcitabine plus cisplatin, an active regimen in advanced urothelial cancer: a phase II trial of the National Cancer Institute of Canada Clinical Trials Group. (8/458)
PURPOSE: To evaluate the efficacy and toxicity of gemcitabine (2', 2'-difluorodeoxycytidine) plus cisplatin in previously untreated patients with advanced transitional-cell carcinoma. PATIENTS AND METHODS: Thirty-one patients with measurable advanced transitional-cell carcinoma who had received no prior chemotherapy for metastatic disease were scheduled to receive gemcitabine 1,000 mg/m(2) intravenously over 30 minutes on days 1, 8, and 15 and cisplatin 70 mg/m(2) over 1 hour on day 2 of a 28-day cycle. Prior adjuvant or neoadjuvant therapy for locally advanced disease was allowed if this was completed more than 1 year before study entry. RESULTS: There were six complete responses and 10 partial responses in 28 assessable patients, for an overall response rate of 16 of 28 (57%). The response rate on an intent-to-treat basis was 16 of 31 patients (52%). The median survival is 13.2 months, with 18 patients still alive at this time. Toxicity was primarily hematologic, with 12 of 31 patients (39%) having > or = grade 3 granulocytopenia and 17 of 31 (55%) having > or = grade 3 thrombocytopenia. Two patients had febrile neutropenia. All patients required a dose modification of gemcitabine at some point in their therapy; the primary reason was thrombocytopenia and/or neutropenia. CONCLUSION: Gemcitabine plus cisplatin is an active regimen for the treatment of urothelial cancer. (+info)
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Agranulocytosis - Wikipedia
TREATMENT OF DRUG-INDUCED AGRANULOCYTOSIS WITH GRANULOCYTE-COLONY STIMULATING FACTOR<...
Pentazocine and Agranulocytosis | Annals of Internal Medicine | American College of Physicians
Agranulocytosis Definition, Symptoms And Treatments | Mediologiest
Neutropenia (granolocytopenia) and agranulocytosis, with some cases of aplastic anaemia (second series) | Wellcome Collection
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Agranulocytosis
... "agranulocytosis" (which can be misinterpreted as "agranulocyt-osis", meaning proliferation of agranulocytes (i.e. lymphocytes ... The terms agranulocytosis, granulocytopenia and neutropenia are sometimes used interchangeably. Agranulocytosis implies a more ... Agranulocytosis may be asymptomatic, or may clinically present with sudden fever, rigors and sore throat. Infection of any ... Agranulocytosis, also known as agranulosis or granulopenia, is an acute condition involving a severe and dangerous lowered ...
Protriptyline
Agranulocytosis; bone marrow depression; leukopenia;thrombocytopenia; purpura; eosinophilia. Gastrointestinal: Nausea and ...
Jerome T. Syverton
Lawrence, J. S.; Syverton, J. T.; Shaw, J. S.; Smith, F. P. (1940). "Infectious feline agranulocytosis". The American Journal ... Lawrence, J. S.; Syverton, J. T. (1938). "Spontaneous Agranulocytosis in the Cat". Experimental Biology and Medicine. 38 (5): ...
Severe congenital neutropenia
Kostmann R (1956). "Infantile genetic agranulocytosis; agranulocytosis infantilis hereditaria". Acta Paediatr. 45 (Suppl 105): ...
Cinepazide
Reactions Weekly 305(1):1. June 1990 Cinepazide-related agranulocytosis Laporte JR, Capellà D, Juan J (1990). "Agranulocytosis ... In 1988 the drug was withdrawn from the market in Spain due to risk of agranulocytosis; other countries where the drug was ...
Dapsone
Agranulocytosis occurs rarely when dapsone is used alone but more frequently in combination regimens for malaria prophylaxis. ... Firkin FC, Mariani AF (1977). "Agranulocytosis due to dapsone". Med. J. Aust. 2 (8): 247-51. doi:10.5694/j.1326-5377.1977. ...
Complete blood count
Wiciński, M; Węclewicz, MM (2018). "Clozapine-induced agranulocytosis/granulocytopenia". Current Opinion in Hematology. 25 (1 ... agranulocytosis). Because anemia during pregnancy can result in poorer outcomes for the mother and her baby, the complete blood ...
Levamisole induced necrosis syndrome
Caldwell, K. B.; Graham, O. Z.; Arnold, J. J. (2012). "Agranulocytosis from Levamisole-Adulterated Cocaine". The Journal of the ... Several cases of severe agranulocytosis associated with cocaine use have been reported since 2006. With the recently recognized ... Potential risks of levamisole-laced cocaine include neutropenia, agranulocytosis, arthralgias, retiform purpura, skin necrosis ...
Phenylbutazone
... can also cause agranulocytosis. Phenylbutazone amplifies the anticoagulant effect of vitamin K antagonists such ...
Pecazine
... was implicated in a number of cases of agranulocytosis and was subsequently withdrawn from the market. More recently, ... Drake M, Honey NK (November 1957). "Agranulocytosis during mepazine therapy". Med. J. Aust. 44 (20): 726-7. doi:10.5694/j.1326- ... Sherman S, Baur E, Klahre H, Lever PG (February 1958). "Agranulocytosis after 10(N-methyl-piperdyl-3-methyl)phenothiazine, with ... Feldman PE, Bertone J, Panthel H (March 1957). "Fatal agranulocytosis during treatment with pacatal". Am J Psychiatry. 113 (9 ...
Enalapril
Agranulocytosis has been observed with Enalapril. Normally, angiotensin I is converted to angiotensin II by an angiotensin- ...
Leukopenia
Agranulocytosis is an acute form of neutropenia. Low white cell count may be due to acute viral infections, such as a cold or ...
Mebendazole
Andersohn F, Konzen C, Garbe E (May 2007). "Systematic review: agranulocytosis induced by nonchemotherapy drugs". Annals of ... with a risk of agranulocytosis in rare cases. Carbamazepine and phenytoin lower serum levels of mebendazole. Cimetidine does ...
Pyrithyldione
Agranulocytosis was sometimes reported as adverse effect. Pyrithyldione is also a CYP2D6 inducer but is not as potent as ... Ibáñez L, BallarÃn E, Pérez E, Vidal X, Capellà D, Laporte JR (January 2000). "Agranulocytosis induced by pyrithyldione, a ... Covner AH, Halpern SL (January 1950). "Fatal agranulocytosis following therapy with presidon (3,3-diethyl-2,4- ...
Phenytoin
Other side effects may include: agranulocytosis, aplastic anemia, decreased white blood cell count, and a low platelet count. ... Sharafuddin MJ, Spanheimer RG, McClune GL (1991). "Phenytoin-induced agranulocytosis: a nonimmunologic idiosyncratic reaction ...
Antithyroid agent
The most dangerous side-effect is agranulocytosis (1/250, more in PTU); this is an idiosyncratic reaction which generally ... Zambrana, J.; Zambrana, F.; Neto, F.; Gonçalves, A.; Zambrana, F.; Ushirohira, J. (2005). "Agranulocytosis with tonsillitis ...
List of withdrawn drugs
Nancy Y Zhu; Donald F. LeGatt; A Robert Turner (February 2009). "Agranulocytosis After Consumption of Cocaine Adulterated With ... Centers for Disease Control and Prevention (CDC) (December 2009). "Agranulocytosis associated with cocaine use - four States, ...
Levamisole
One of the more serious side effects of levamisole is agranulocytosis, or the depletion of the white blood cells. In particular ... Levamisole suppresses the production of white blood cells, resulting in neutropenia and agranulocytosis. With the increasing ... Zhu NY, Legatt DF, Turner AR (February 2009). "Agranulocytosis after consumption of cocaine adulterated with levamisole". ... Centers for Disease Control Prevention (CDC) (December 2009). "Agranulocytosis associated with cocaine use - four States, March ...
Superficial siderosis
"Deferiprone-induced agranulocytosis: 20 years of clinical observations". American Journal of Hematology. 91 (10): 1026-31. doi: ...
Chloroquine
Pancytopenia, aplastic anemia, reversible agranulocytosis, low blood platelets, neutropenia. Chloroquine has not been shown to ...
H2 receptor antagonist
Metiamide was an effective agent; however, it was associated with unacceptable nephrotoxicity and agranulocytosis. It was ...
Cimetidine
Metiamide was an effective agent; it was associated, however, with unacceptable nephrotoxicity and agranulocytosis. The ...
NAD(P)H dehydrogenase, quinone 2
2004). "NQO2 gene is associated with clozapine-induced agranulocytosis". Tissue Antigens. 62 (6): 483-91. doi:10.1046/j.1399- ...
Granulocyte
Closely related terms include agranulocytosis (etymologically, "no granulocytes at all"; clinically, granulocyte levels less ...
Neutropenia
Acquired agranulocytosis is much more common than the congenital form. The common causes of acquired agranulocytosis including ... Agranulocytosis has a mortality rate of 7-10%. To manage this, the application of granulocyte colony stimulating factor (G-CSF ... Agranulocytosis can be presented as whitish or greyish necrotic ulcer in oral cavity, without any sign of inflammation. ...
Metamizole
... including agranulocytosis. A study by one of the manufacturers of the drug found the risk of agranulocytosis within the first ... A possible factor in these deaths might have been a side effect of metamizole that can cause agranulocytosis (a lowering of ... The relative risk for agranulocytosis appears to greatly vary according to the country of estimates on said rate and opinion on ... It is suggested that some populations are more prone to suffer from metamizole induced agranulocytosis than others. As an ...
Life expectancy
It has been shown that the psychiatric medication olanzapine can increase risk of developing agranulocytosis, among other ... J. Alvir (1993). "Clozapine-Induced Agranulocytosis -- Incidence and Risk Factors in the United States". New England Journal of ...
Lobaplatin
Common side effects include agranulocytosis, thrombocytopenia, anaemia, leukopenia, nausea and vomiting. Lobaplatin was first ...
Calcium dobesilate
Rare cases of agranulocytosis have also been reported in medical literature. The rarity of the latter adverse effect led ...
Graves' disease
The most dangerous side effect is agranulocytosis (1/250, more in PTU). Others include granulocytopenia (dose-dependent, which ... and lifelong treatment with antithyroid drugs carries some side effects such as agranulocytosis and liver disease. Side effects ...
Agranulocytosis: MedlinePlus Medical Encyclopedia
Agranulocytosis Associated with Cocaine Use --- Four States, March 2008--November 2009
However, agranulocytosis as a result of exposure to cocaine containing levamisole, a known cause of agranulocytosis, was ... Descriptive epidemiology of agranulocytosis. Arch Intern Med 1992;152:1475--80.. * Ibáñez L, Vidal X, BallarÃn E, Laport JR. ... For example, agranulocytosis is not a reportable condition to health departments, patients might not disclose cocaine use to ... Agranulocytosis is an uncommon condition (7.2 cases per 1 million population per year, excluding patients with cancer and ...
2023 ICD-10-CM Diagnosis Code D70.2: Other drug-induced agranulocytosis
ICD 10 code for Other drug-induced agranulocytosis. Get free rules, notes, crosswalks, synonyms, history for ICD-10 code D70.2. ... Other drug-induced agranulocytosis. 2016 2017 2018 2019 2020 2021 2022 2023 Billable/Specific Code *D70.2 is a billable/ ... Agranulocytosis (chronic) (cyclical) (genetic) (infantile) (periodic) (pernicious) D70.9. - see also Neutropenia. ICD-10-CM ...
Thiamazole-Induced Agranulocytosis Leading to Abscessus Pneumonia-Rare, But Challenging | Archivos de BronconeumologÃa
DailyMed - CAPTOPRIL tablet
Neutropenia/Agranulocytosis. Neutropenia (,1000/mm3) with myeloid hypoplasia has resulted from use of captopril. About half of ... Hematologic : Neutropenia/agranulocytosis has occurred (see WARNINGS). Cases of anemia, thrombocytopenia, and pancytopenia have ... In using captopril, consideration should be given to the risk of neutropenia/ agranulocytosis (see WARNINGS). ... the neutropenic patients developed systemic or oral cavity infections or other features of the syndrome of agranulocytosis. ...
Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles - The University of Liverpool Repository
Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles.pdf - OA Published Version Download (1MB) ... Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles ... Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles ... Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles. Nature Communications, 5. ...
IMSEAR at SEARO: Agranulocytosis following isoniazid--a case report.
Propylthiouracil (Propylthiouracil Tablet): Uses, Dosage, Side Effects, Interactions, Warning
Agranulocytosis. Agranulocytosis occurs in approximately 0.2% to 0.5% of patients and is a potentially life-threatening side ... Agranulocytosis typically occurs within the first 3 months of therapy. Patients should be instructed to immediately report any ... Agranulocytosis is the most serious effect. Rarely, exfoliative dermatitis, hepatitis, neuropathies or CNS stimulation or ... In such cases, white blood cell and differential counts should be obtained to determine whether agranulocytosis has developed. ...
Clozapine-induced agranulocytosis | Psychiatry Xagena
Clozapine-induced agranulocytosis Drug-induced agranulocytosis is a potentially life-threatening, idiosyncratic reaction ... Clozapine-induced agranulocytosis ( CLIA ) is an obstacle to Clozapine use in a much larger number of patients with ... However, its propensity to cause neutropenia and agranulocytosis was soon recognized, leading to its withdrawal. A double-blind ... Despite the reduction of the incidence of Clozapine-induced agranulocytosis due to blood monitoring programs, and reduced ...
Carbamazepine: Seizure Medication Side Effects & Dosage
Accuretic: Package Insert / Prescribing Information - Drugs.com
Neutropenia/Agranulocytosis. Another ACE inhibitor, captopril, has been shown to cause agranulocytosis and bone marrow ... Agranulocytosis, Thrombocytopenia, Arthralgia. Angioedema:. Angioedema has been reported in 0.1% of patients receiving ... Aplastic anemia, agranulocytosis, leukopenia, thrombocytopenia, and hemolytic anemia.. RENAL:. Renal failure, renal dysfunction ... Agranulocytosis did occur during quinapril treatment in one patient with a history of neutropenia during previous captopril ...
Methimazole Tablets, USP
Agranulocytosis. Agranulocytosis is potentially a life-threatening adverse reaction of methimazole therapy. Patients should be ... In such cases, white-blood-cell and differential counts should be obtained to determine whether agranulocytosis has developed. ... The drug should be discontinued in the presence of agranulocytosis, aplastic anemia (pancytopenia), and the patients bone ... Aplastic anemia (pancytopenia) or agranulocytosis may be manifested in hours to days. Less frequent events are hepatitis, ...
Mast Cell Activation Syndrome Masquerading as Agranulocytosis | Mast Cell Action
Clinical and Laboratory Features of Drug-Induced Agranulocytosis | Medicalalgorithms.com
Upper Respiratory Tract Infection: Practice Essentials, Background, Pathophysiology
Tardive Dyskinesia: Overview, Pathophysiology, Etiology
Relation of the Allelic Variants of Multidrug Resistance Gene to Agranulocytosis Associated With Clozapine | AVESİS
Clozapine use is associated with leukopenia and more rarely agranulocytosis, which may be lethal. The drug and its metabolites ... Relation of the Allelic Variants of Multidrug Resistance Gene to Agranulocytosis Associated With Clozapine ... Keywords: schizophrenia, clozapine, agranulocytosis, genetic polymorphism, BINDING CASSETTE TRANSPORTERS, P-GLYCOPROTEIN, ... we aimed to investigate the association between these specific ABCB1 polymorphisms and clozapine-associated agranulocytosis ( ...
Phase III Study Comparing the Efficacy and Safety of LA-EP2006 and Neulasta® - Full Text View - ClinicalTrials.gov
This randomized, double-blind trial compared the proposed biosimilar LA-EP2006 with the reference Neulasta® in women (≥18 years) receiving chemotherapy for breast cancer. Therefore patients were randomized to receive LA-EP2006 (n = 159) or the reference product (n = 157) for ≤6 cycles of (neo)-adjuvant TAC (docetaxel 75mg/m^2, doxorubicin 50 mg/m^2, and cyclophosphamide 500mg/m^2) chemotherapy. The primary end point was the duration of severe neutropenia (DSN) during Cycle 1 (defined as number of consecutive days with absolute neutrophil count ,0.5 × 10^9/l). The equivalence was confirmed if 95% CIs were within a ±1 day margin. LA-EP2006 was equivalent to the reference product in DSN (difference: 0.07 days; 95% CI [-0.12, 0.26]). Further, LA-EP2006 and the reference Neulasta® showed no clinically meaningful differences regarding efficacy and safety ...
Biochemistry (1971-75)
Agranulocyte - Wikipedia
Ankylosing Spondylitis and Undifferentiated Spondyloarthropathy Treatment & Management: Approach Considerations, Pharmacologic...
Index of Published Newsletters - Canada.ca
Which medications in the drug class Erythroid Maturation Agents are used in the treatment of Beta Thalassemia?
Psycho-Babble Medication Thread 1120713
Agranulocytosis can be fatal. There is another advantage to oxcarbazepine. It doesnt cause the same sort of sedation and foggy ... oxcarbazepine lacks the side effect of suppressing the immune system in the form of agranulocytosis (stopping the formation of ... oxcarbazepine lacks the side effect of suppressing the immune system in the form of agranulocytosis (stopping the formation of ...
Table 1 - Multiorgan Dysfunction Caused by Travel-associated African Trypanosomiasis - Volume 18, Number 2-February 2012 -...
Neutropenia Causes
Agranulocytoses, Agranulocytosis, Granulocytopenia, Granulocytopenias, AGRANULOCYTOSIS, GRANULOCYTOPENIA, Agranulocytosis NOS, ... Agranulocytosis [Disease/Finding], granulopenia, agranulocytoses, Agranulocytosis NOS (disorder), Agranulocytosis (finding), ... Ontology: Agranulocytosis. (C0001824) Definition (NCI_NCI-GLOSS) A condition in which there is a lower-than-normal number of ... Granulocytopenia (disorder), Granulopenia, Agranulocytosis (disorder), Schultz, Granulocytopenic disorder (disorder), ...
Leukopenia2
- Clozapine use is associated with leukopenia and more rarely agranulocytosis, which may be lethal. (hacettepe.edu.tr)
- Blood dyscrasias such as agranulocytosis, leukopenia and neutropenia are possible with thioridazine treatment. (mental-health-matters.org)
Aplastic2
- Aplastic anemia and agranulocytosis can occur during treatment with Carnexiv. (medicinenet.com)
- The drug should be discontinued in the presence of agranulocytosis, aplastic anemia (pancytopenia), and the patient's bone marrow indices should be monitored. (nih.gov)
Antithyroid drug-induced agranulocytosis1
- The relationship between bone marrow characteristics and the clinical prognosis of antithyroid drug-induced agranulocytosis. (mdedge.com)
Clozapine7
- Clozapine is a particularly effective antipsychotic medication but its use is curtailed by the risk of clozapine-induced agranulocytosis/granulocytopenia (CIAG), a severe adverse drug reaction occurring in up to 1% of treated individuals. (liverpool.ac.uk)
- Clozapine-induced agranulocytosis ( CLIA ) is an obstacle to Clozapine use in a much larger number of patients with schizophrenia. (psychiatrynews.net)
- Despite the reduction of the incidence of Clozapine-induced agranulocytosis due to blood monitoring programs, and reduced mortality from drug-induced agranulocytosis, psychiatrists may be reluctant to prescribe a drug with a potentially fatal side effect. (psychiatrynews.net)
- In this study, we aimed to investigate the association between these specific ABCB1 polymorphisms and clozapine-associated agranulocytosis (CAA). (hacettepe.edu.tr)
- Neutropenia and agranulocytosis in patients receiving clozapine in the UK and Ireland. (mdedge.com)
- The decision to continue clozapine during chemotherapy is challenging and should weigh the risk of agranulocytosis against that of psychiatric destabilization. (mdedge.com)
- Because clozapine and chemotherapy are both associated with agranulocytosis, there is concern that concurrent treatment could increase this risk in an additive or synergistic manner. (mdedge.com)
Neutropenia and Agranulocytosis2
- However, its propensity to cause neutropenia and agranulocytosis was soon recognized, leading to its withdrawal. (psychiatrynews.net)
- Nonchemotherapy drug-induced neutropenia and agranulocytosis: could medications be the culprit? (mdedge.com)
Drug-induced2
- Drug-induced agranulocytosis is a potentially life-threatening, idiosyncratic reaction characterized by a profound decrease in neutrophil count and susceptibility to infection. (psychiatrynews.net)
- Drug-induced agranulocytosis is associated with a number of clinical and laboratory findings. (medicalalgorithms.com)
Nephrotoxicity1
- however, it was associated with unacceptable nephrotoxicity and agranulocytosis . (bionity.com)
Neuroleptic1
- agranulocytosis, neuroleptic malignant syndrome. (mims.com)
Cocaine users3
- In the midst of the NMDOH investigation, in November 2008, public health officials in British Columbia and Alberta, Canada, reported detecting levamisole (an antihelminthic drug used mainly in veterinary medicine and a known cause of agranulocytosis [ 1 ]) from clinical specimens and drug paraphernalia of cocaine users with agranulocytosis. (cdc.gov)
- But lately, doctors have been seeing more and more cocaine users with mysterious cases of agranulocytosis linked to a mysterious cutting agent called levamisole. (thestranger.com)
- In April 2008, a lab in New Mexico reported an unexplained cluster of 11 agranulocytosis cases in cocaine users. (thestranger.com)
Granulocytes1
- When the body has too few granulocytes, the condition is called agranulocytosis. (medlineplus.gov)
Levamisole4
- This report summarizes the investigations in New Mexico and Washington, which suggested that levamisole in cocaine was the likely cause of the agranulocytosis. (cdc.gov)
- However, in November 2008, NMDOH investigators learned that levamisole * had been isolated from clinical specimens and drug paraphernalia of five cocaine-using patients with agranulocytosis in British Columbia and Alberta, Canada. (cdc.gov)
- Although levamisole had been isolated previously from cocaine, cocaine paraphernalia, and persons who used cocaine ( 2--4 ), agranulocytosis had not been associated previously with cocaine use. (cdc.gov)
- In January 2009, NMDOH SLD detected levamisole using gas chromatography/mass spectrophotometry (GC/MS) in a postmortem blood specimen from patient 3, who had a diagnosis of Serratia marcescans sepsis and agranulocytosis. (cdc.gov)
Incidence1
- 8. Apinantriyo B, Lekhakula A, Rujirojindakul P. Incidence, etiology and bone marrow characteristics of non-chemotherapy-induced agranulocytosis. (mdedge.com)
Potentially2
- Agranulocytosis is potentially a life-threatening adverse reaction of methimazole therapy. (nih.gov)
- Some data indicate that individuals with a high level of desmethylclozapine are more susceptible to developing agranulocytosis, a potentially lethal adverse event. (spectroscopyonline.com)
Medications2
- Agranulocytosis is rare and typically caused by medications: Antibiotics, gold salts (to treat arthritis), and some anti-psychotic drugs can trigger the crash. (thestranger.com)
- If a physician treats enough patients who are hyperthyroid, eventually he or she will encounter a patient who develops agranulocytosis or hepatitis from the antithyroid medications. (medscape.com)
Severe1
- Even as far back as 40 years ago, it was recognized that patients can develop severe agranulocytosis, a severe form of neutropenia. (ajmc.com)
Autoimmune1
- During levamisole's early clinical trials for cancer and autoimmune disorders, around 10 percent of the patients developed agranulocytosis. (thestranger.com)
Warnings1
- It has 5 black box warnings, including that agranulocytosis is a problem. (ajmc.com)
Fatal1
- Agranulocytosis can be fatal. (dr-bob.org)
Clinical1
- In April 2008, a clinical reference laboratory in New Mexico notified the New Mexico Department of Health (NMDOH) of a cluster of unexplained agranulocytosis cases confirmed by bone marrow histopathology during the preceding 2 months. (cdc.gov)
Diagnosis2
- Health-care providers should consider these findings in the differential diagnosis of agranulocytosis, and public health officials should be aware of cases of agranulocytosis associated with cocaine use. (cdc.gov)
- The patient had been admitted to the hospital 5 months before death with a diagnosis of agranulocytosis and an absolute neutrophil count (ANC) of zero. (cdc.gov)
Patients7
- Four of the six patients had been undergoing treatments that were thought to have caused agranulocytosis (i.e., cancer treatment, gabapentin, sulfasalazine, and an unidentified herbal remedy obtained outside of the country). (cdc.gov)
- NMDOH conducted medical record reviews, physician interviews, and patient interviews for all patients with unexplained agranulocytosis reported to NMDOH. (cdc.gov)
- Patients should be instructed to immediately report to their physicians any symptoms suggestive of agranulocytosis, such as fever or sore throat. (nih.gov)
- Agranulocytosis was reported in five of these patients. (worstpills.org)
- But too many patients came down with agranulocytosis, the studies were discontinued, and the FDA withdrew its approval of the drug. (thestranger.com)
- In years to come, we may have the ability to write individualized prescriptions after testing our patients for vulnerability to limiting side effects such as weight gain and agranulocytosis and for their potential response to certain drugs. (psychiatrictimes.com)
- 1% of patients, medication-related agranulocytosis can happen suddenly. (exxcellence.org)
Blood2
- If you are having treatment or taking medicine that could cause agranulocytosis, your health care provider will use blood tests to monitor you. (medlineplus.gov)
- Oxcarbazepine seems to be as potent as carbamazepine in the majority of studies comparing their efficacies in seizure disorders However, oxcarbazepine lacks the side effect of suppressing the immune system in the form of agranulocytosis (stopping the formation of granulocyte white blood cells). (dr-bob.org)
Adverse effect1
- Agranulocytosis is a major adverse effect associated with administration of this agent. (nih.gov)
Bone1
- 6. Azadeh N, Kelemen K, Fonseca R. Amitriptyline-induced agranulocytosis with bone marrow confirmation. (mdedge.com)
Cases5
- NMDOH began an investigation, which identified cocaine use as a common exposure in 11 cases of otherwise unexplained agranulocytosis during April 2008--November 2009. (cdc.gov)
- In a separate investigation during April--November 2009, public health officials in Seattle, Washington, identified 10 cases of agranulocytosis among persons with a history of cocaine use. (cdc.gov)
- After learning of the unexplained agranulocytosis in April 2008, NMDOH investigated the cases through medical record reviews and interviews with health-care providers. (cdc.gov)
- During the next 8 months, passive surveillance for additional cases resulted in seven additional cases of agranulocytosis reported to NMDOH, six from the same laboratory that sent the original alert to NMDOH, and one decedent (patient 3) from the New Mexico Office of the Medical Investigator. (cdc.gov)
- A discussion of six cases of agranulocytosis. (nih.gov)
Risk1
- Can this medication be continued, or is the risk of agranulocytosis too high? (mdedge.com)
Report1
- IMSEAR at SEARO: Agranulocytosis following isoniazid--a case report. (who.int)