Progeria: An abnormal congenital condition, associated with defects in the LAMIN TYPE A gene, which is characterized by premature aging in children, where all the changes of cell senescence occur. It is manifested by premature greying; hair loss; hearing loss (DEAFNESS); cataracts (CATARACT); ARTHRITIS; OSTEOPOROSIS; DIABETES MELLITUS; atrophy of subcutaneous fat; skeletal hypoplasia; elevated urinary HYALURONIC ACID; and accelerated ATHEROSCLEROSIS. Many affected individuals develop malignant tumors, especially SARCOMA.Polynesia: The collective name for the islands of the central Pacific Ocean, including the Austral Islands, Cook Islands, Easter Island, HAWAII; NEW ZEALAND; Phoenix Islands, PITCAIRN ISLAND; SAMOA; TONGA; Tuamotu Archipelago, Wake Island, and Wallis and Futuna Islands. Polynesians are of the Caucasoid race, but many are of mixed origin. Polynesia is from the Greek poly, many + nesos, island, with reference to the many islands in the group. (From Webster's New Geographical Dictionary, 1988, p966 & Room, Brewer's Dictionary of Names, 1992, p426)Lamin Type A: A subclass of developmentally regulated lamins having a neutral isoelectric point. They are found to disassociate from nuclear membranes during mitosis.Aging, Premature: Changes in the organism associated with senescence, occurring at an accelerated rate.Farnesyltranstransferase: An enzyme that catalyzes the synthesis of geranylgeranyl diphosphate from trans, trans-farnesyl diphosphate and isopentenyl diphosphate.ChileCell Nucleus Shape: The quality of surface form or outline of the CELL NUCLEUS.Skin: The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.Lettuce: Any of the various plants of the genus Lactuca, especially L. sativa, cultivated for its edible leaves. (From American Heritage Dictionary, 2d ed)Skin Aging: The process of aging due to changes in the structure and elasticity of the skin over time. It may be a part of physiological aging or it may be due to the effects of ultraviolet radiation, usually through exposure to sunlight.Tiopronin: Sulfhydryl acylated derivative of GLYCINE.Skin DiseasesSkin Neoplasms: Tumors or cancer of the SKIN.Diet: Regular course of eating and drinking adopted by a person or animal.DenmarkPercussion: Act of striking a part with short, sharp blows as an aid in diagnosing the condition beneath the sound obtained.Physical Examination: Systematic and thorough inspection of the patient for physical signs of disease or abnormality.Auscultation: Act of listening for sounds within the body.Pallor: A clinical manifestation consisting of an unnatural paleness of the skin.Observer Variation: The failure by the observer to measure or identify a phenomenon accurately, which results in an error. Sources for this may be due to the observer's missing an abnormality, or to faulty technique resulting in incorrect test measurement, or to misinterpretation of the data. Two varieties are inter-observer variation (the amount observers vary from one another when reporting on the same material) and intra-observer variation (the amount one observer varies between observations when reporting more than once on the same material).Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)Physical Endurance: The time span between the beginning of physical activity by an individual and the termination because of exhaustion.Exercise: Physical activity which is usually regular and done with the intention of improving or maintaining PHYSICAL FITNESS or HEALTH. Contrast with PHYSICAL EXERTION which is concerned largely with the physiologic and metabolic response to energy expenditure.Physical Conditioning, Animal: Diet modification and physical exercise to improve the ability of animals to perform physical activities.DNA, Mitochondrial: Double-stranded DNA of MITOCHONDRIA. In eukaryotes, the mitochondrial GENOME is circular and codes for ribosomal RNAs, transfer RNAs, and about 10 proteins.Exercise Test: Controlled physical activity which is performed in order to allow assessment of physiological functions, particularly cardiovascular and pulmonary, but also aerobic capacity. Maximal (most intense) exercise is usually required but submaximal exercise is also used.Exercise Therapy: A regimen or plan of physical activities designed and prescribed for specific therapeutic goals. Its purpose is to restore normal musculoskeletal function or to reduce pain caused by diseases or injuries.Muscle, Skeletal: A subtype of striated muscle, attached by TENDONS to the SKELETON. Skeletal muscles are innervated and their movement can be consciously controlled. They are also called voluntary muscles.Telomere: A terminal section of a chromosome which has a specialized structure and which is involved in chromosomal replication and stability. Its length is believed to be a few hundred base pairs.G-Quadruplexes: Higher-order DNA and RNA structures formed from guanine-rich sequences. They are formed around a core of at least 2 stacked tetrads of hydrogen-bonded GUANINE bases. They can be formed from one two or four separate strands of DNA (or RNA) and can display a wide variety of topologies, which are a consequence of various combinations of strand direction, length, and sequence. (From Nucleic Acids Res. 2006;34(19):5402-15)Telomerase: An essential ribonucleoprotein reverse transcriptase that adds telomeric DNA to the ends of eukaryotic CHROMOSOMES.Cell Aging: The decrease in the cell's ability to proliferate with the passing of time. Each cell is programmed for a certain number of cell divisions and at the end of that time proliferation halts. The cell enters a quiescent state after which it experiences CELL DEATH via the process of APOPTOSIS.Telomere-Binding Proteins: Proteins that specifically bind to TELOMERES. Proteins in this class include those that perform functions such as telomere capping, telomere maintenance and telomere stabilization.Telomeric Repeat Binding Protein 2: A ubiquitously expressed telomere-binding protein that is present at TELOMERES throughout the cell cycle. It is a suppressor of telomere elongation and may be involved in stabilization of telomere length. It is structurally different from TELOMERIC REPEAT BINDING PROTEIN 1 in that it contains basic N-terminal amino acid residues.Recombination, Genetic: Production of new arrangements of DNA by various mechanisms such as assortment and segregation, CROSSING OVER; GENE CONVERSION; GENETIC TRANSFORMATION; GENETIC CONJUGATION; GENETIC TRANSDUCTION; or mixed infection of viruses.Postural Balance: A POSTURE in which an ideal body mass distribution is achieved. Postural balance provides the body carriage stability and conditions for normal functions in stationary position or in movement, such as sitting, standing, or walking.Vestibular Diseases: Pathological processes of the VESTIBULAR LABYRINTH which contains part of the balancing apparatus. Patients with vestibular diseases show instability and are at risk of frequent falls.Sensation Disorders: Disorders of the special senses (i.e., VISION; HEARING; TASTE; and SMELL) or somatosensory system (i.e., afferent components of the PERIPHERAL NERVOUS SYSTEM).Adenosine Triphosphate: An adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.Solitary Pulmonary Nodule: A single lung lesion that is characterized by a small round mass of tissue, usually less than 1 cm in diameter, and can be detected by chest radiography. A solitary pulmonary nodule can be associated with neoplasm, tuberculosis, cyst, or other anomalies in the lung, the CHEST WALL, or the PLEURA.Autonomic Fibers, Preganglionic: NERVE FIBERS which project from the central nervous system to AUTONOMIC GANGLIA. In the sympathetic division most preganglionic fibers originate with neurons in the intermediolateral column of the SPINAL CORD, exit via ventral roots from upper thoracic through lower lumbar segments, and project to the paravertebral ganglia; there they either terminate in SYNAPSES or continue through the SPLANCHNIC NERVES to the prevertebral ganglia. In the parasympathetic division the fibers originate in neurons of the BRAIN STEM and sacral spinal cord. In both divisions the principal transmitter is ACETYLCHOLINE but peptide cotransmitters may also be released.Adrenergic Fibers: Nerve fibers liberating catecholamines at a synapse after an impulse.Cataloging: Activities performed in the preparation of bibliographic records for CATALOGS. It is carried out according to a set of rules and contains information enabling the user to know what is available and where items can be found.Catalogs, LibraryBook Classification: A general term covering bibliographical and bibliothecal classifications. It mostly refers to library CLASSIFICATION for arrangement of books and documents on the shelves. (Harrod's Librarians' Glossary, 7th ed, p85)Weight Gain: Increase in BODY WEIGHT over existing weight.Energy Metabolism: The chemical reactions involved in the production and utilization of various forms of energy in cells.Cell Transformation, Neoplastic: Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.Body Weight: The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.Stevens-Johnson Syndrome: Rare cutaneous eruption characterized by extensive KERATINOCYTE apoptosis resulting in skin detachment with mucosal involvement. It is often provoked by the use of drugs (e.g., antibiotics and anticonvulsants) or associated with PNEUMONIA, MYCOPLASMA. It is considered a continuum of Toxic Epidermal Necrolysis.Faculty, Medical: The teaching staff and members of the administrative staff having academic rank in a medical school.Proteins: Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.Sister Mary Joseph's Nodule: Metastatic lesion of the UMBILICUS associated with intra-abdominal neoplasms especially of the GASTROINTESTINAL TRACT or OVARY.Biology: One of the BIOLOGICAL SCIENCE DISCIPLINES concerned with the origin, structure, development, growth, function, genetics, and reproduction of animals, plants, and microorganisms.Cell Biology: The study of the structure, behavior, growth, reproduction, and pathology of cells; and the function and chemistry of cellular components.Umbilicus: The pit in the center of the ABDOMINAL WALL marking the point where the UMBILICAL CORD entered in the FETUS.
Physical and functional interaction between p53 and the Werner's syndrome protein. (1/201)
Werner's syndrome is a human autosomal recessive disorder leading to premature aging. The mutations responsible for this disorder have recently been localized to a gene (WRN) encoding a protein that possesses DNA helicase and exonuclease activities. Patients carrying WRN gene mutations exhibit an elevated rate of cancer, accompanied by increased genomic instability. The latter features are also characteristic of the loss of function of p53, a tumor suppressor that is very frequently inactivated in human cancer. Moreover, changes in the activity of p53 have been implicated in the onset of cellular replicative senescence. We report here that the WRN protein can form a specific physical interaction with p53. This interaction involves the carboxyl-terminal part of WRN and the extreme carboxyl terminus of p53, a region that plays an important role in regulating the functional state of p53. A small fraction of WRN can be found in complex with endogenous p53 in nontransfected cells. Overexpression of WRN leads to augmented p53-dependent transcriptional activity and induction of p21(Waf1) protein expression. These findings support the existence of a cross-talk between WRN and p53, which may be important for maintaining genomic integrity and for preventing the accumulation of aberrations that can give rise to premature senescence and cancer. (+info)Unique mutations in mitochondrial DNA of senescence-accelerated mouse (SAM) strains. (2/201)
Mitochondrial DNA (mtDNA) is exclusively inherited maternally and hence could offer a good method for tracing the lineage of mouse strains. We examined the mtDNA sequence of senescence-accelerated mouse (SAM) strains as well as other laboratory strains of inbred mice to deduce the ancestral strain of SAM. Four unique mutations were identified at bases 2256, 10,847, 11,181, and 13,053 in SAM strains. The mutations were not found in other mouse strains including AKR/J, one of the parental strains of SAM. Comparison of the mtDNA sequences also led to the consensus mtDNA sequence of laboratory strains of inbred mice. The seven laboratory strains of common inbred mice showed polymorphisms at base 9348, thymine repeat from base 9818, and adenine repeat from base 9821, and could be classified into five types by combination of the differences. Although we could not identify mouse strains with the same type of mtDNA as SAM in this study, the polymorphisms would provide a promising clue to ascertain the ancestral strain(s) of SAM. The polymorphism in mtDNA could be used to ascertain the genealogy of other mouse strains as well. (+info)Antioxidant systems in tissues of senescence accelerated mice. (3/201)
Significant decrease in the level of lipid antioxidants (measured from the kinetics of the induced chemiluminescence in brain homogenate) and of the hydrophilic antioxidant carnosine as well was observed in the brain of 14-16-month-old mice of SAMP1 line, which is characterized by accelerated accumulation of senile features, in comparison with the control line SAMR1. In the brain of SAMP1 animals the activity of cytosolic Cu/Zn-containing superoxide dismutase (SOD) was reduced, while the activity of membrane-bound Mn-SOD was at an extremely low level. The activity of glutathione-dependent enzymes (glutathione peroxidase, glutathione reductase, and glutathione transferase) did not differ in the brain of SAMP1 and SAMR1 animals, and catalase activity was similarly low in both cases. At the same time, excess concentration of excitotoxic compounds, significantly exceeding that for the control line, was determined in the brain and blood of SAMP1 animals. The activity of glutathione enzymes in liver and heart as well as the activity of cytosolic Cu/Zn-SOD in liver did not differ in the two studied lines, while the activity of erythrocyte glutathione peroxidase was slightly increased, and the activity of liver catalase and erythrocyte Cu/Zn-SOD was significantly decreased for SAMP1 compared with SAMR1. The results demonstrate that the accelerated ageing of SAMP1 animals is connected to a significant extent with the decreased efficiency of the systems utilizing reactive oxygen species (ROS) in tissues. (+info)Association of human aging with a functional variant of klotho. (4/201)
Mice deficient in Klotho gene expression exhibit a syndrome resembling premature human aging. To determine whether variation in the human KLOTHO locus contributes to survival, we applied two newly characterized polymorphic microsatellite markers flanking the gene in a population-based association study. In a cohort chosen for its homogeneity, Bohemian Czechs, we demonstrated significant differences in selected marker allele frequencies between newborn and elderly individuals (P < 0.05). These results precipitated a search for functional variants of klotho. We identified an allele, termed KL-VS, containing six sequence variants in complete linkage disequilibrium, two of which result in amino acid substitutions F352V and C370S. Homozygous elderly individuals were underrepresented in three distinct populations: Bohemian Czechs, Baltimore Caucasians, and Baltimore African-Americans [combined odds ratio (OR) = 2.59, P < 0.0023]. In a transient transfection assay, secreted levels of klotho harboring V352 are reduced 6-fold, whereas extracellular levels of the S370 form are increased 2.9-fold. The V352/S370 double mutant exhibits an intermediate phenotype (1.6-fold increase), providing a rare example of intragenic complementation in cis by human single nucleotide polymorphisms. The remarkable conservation of F352 among homologous proteins suggests that it is functionally important. The corresponding substitution, F289V, in the closest human klotho paralog with a known substrate, cBGL1, completely eliminates its ability to cleave p-nitrophenyl-beta-D-glucoside. These results suggest that the KL-VS allele influences the trafficking and catalytic activity of klotho, and that variation in klotho function contributes to heterogeneity in the onset and severity of human age-related phenotypes. (+info)Life span and renal morphological characterization of the SAMP1//Ka mouse. (5/201)
The senescence-accelerated-mouse prone 1 (SAMP1) is considered to be a model of accelerated senility and it also develops severe kidney damage. The SAMP1//Ka mouse is a specific pathogen free (SPF) subline of SAMP1. The present study examined the life span of the SAMP1//Ka mouse and morphologically investigated the kidneys of this animal at 3, 4, 5, 9, 12, 15, 18 and 24 months of age. Males survived for an average of 25 months and females for 28 months. The median lifespan was 18 months for males and 20 for females. Focal cell infiltration and thickening of the basement membrane in the glomerular capsules or tubules appeared from 4 months of age. At 12 months old, glomerular lesions with expansion of the mesangial matrix and thickening of the basement membrane as well as scar lesions in the outer cortex appeared, and amyloid was deposited in the interstitium or glomeruli from 18 months of age. Morphometrically, although the area of the kidney sections was increased at 24 months of age, the diameter of the renal corpuscles, the number of nuclei of the proximal convoluted tubules and the percentage of renal corpuscles with a cuboidal glomerular capsule did not change with age. The results of the present study indicate that the life span of the SAMP1//Ka is increased and that their age-related renal changes differ from those of the original SAMP1. (+info)Premature aging in mice deficient in DNA repair and transcription. (6/201)
One of the factors postulated to drive the aging process is the accumulation of DNA damage. Here, we provide strong support for this hypothesis by describing studies of mice with a mutation in XPD, a gene encoding a DNA helicase that functions in both repair and transcription and that is mutated in the human disorder trichothiodystrophy (TTD). TTD mice were found to exhibit many symptoms of premature aging, including osteoporosis and kyphosis, osteosclerosis, early greying, cachexia, infertility, and reduced life-span. TTD mice carrying an additional mutation in XPA, which enhances the DNA repair defect, showed a greatly accelerated aging phenotype, which correlated with an increased cellular sensitivity to oxidative DNA damage. We hypothesize that aging in TTD mice is caused by unrepaired DNA damage that compromises transcription, leading to functional inactivation of critical genes and enhanced apoptosis. (+info)Ageing: repair and transcription keep us from premature ageing. (7/201)
Trichothiodystrophy (TTD) is a complex disorder caused by mutations in the XPD gene which affect both DNA repair and transcription. A mouse with a TTD mutation has now been found to display remarkable signs of premature ageing. (+info)Insufficient interleukin-2 production from splenic CD4+ T cells causes impaired cell proliferation and early apoptosis in SAMP1, a strain of senescence-accelerated mouse. (8/201)
We examined the proliferative and cytokine-producing activities of CD4+ T cells from young mice of the senescence-accelerated mouse strain SAMP1, which had shown markedly low T-dependent antibody-producing responses. When splenic T cells were cultured with concanavalin A (Con A), the percentage of CD4+ cells decreased earlier in SAMP1 than in C3H/He mice. At 40 hr of culture, the percentage of BrdU-labelled proliferating CD4+ cells increased strongly in C3H/He, but only slightly in SAMP1. When purified CD4+ T cells were cultured with Con A, the percentage of 5-bromo-2'-deoxyuridine (BrdU)-labelled cells peaked at around 48 hr of culture in both strains, but decreased significantly at 64 hr in SAMP1. The production of interleukin (IL)-2 but not IL-4 or interferon-gamma (IFN-gamma) was significantly lower in SAMP1 than in C3H/He at 48 hr of culture. IL-2 production was also markedly low in SAMP1, even under the stimulation of anti-CD3 with anti-CD28 antibodies. The frequency of cells producing IL-2 was significantly lower in SAMP1 than in C3H/He at 6-24 hr of culture with Con A. The percentage of annexin-positive and propidium iodide (PI)-negative apoptotic cells was significantly higher in SAMP1 than in C3H/He at 96 hr of culture. Exogenous IL-2 prevented the decrease in BrdU-labelled cells and the increase in apoptotic cells in the SAMP1 cell culture. These results indicate that SAMP1 CD4+ T cells cannot produce IL-2 at levels sufficient to support cell proliferation and survival. This may account for the weak T-dependent antibody response in SAMP1 mice. (+info)Premature aging[edit]. Complex regulatory mechanisms control metabolism. Recent epidemiologic evidence suggests that there is a ... Keisala T, Minasyan A, Lou YR, Zou J, Kalueff AV, Pyykkö I, Tuohimaa P (July 2009). "Premature aging in vitamin D receptor ... Animal research suggests that both excess and deficiency of vitamin D appears to cause abnormal functioning and premature aging ... Tuohimaa P (March 2009). "Vitamin D and aging". The Journal of Steroid Biochemistry and Molecular Biology. 114 (1-2): 78-84. ...
... s (PACs), also known as atrial premature complexes (APC) or atrial premature beats (APB), are a ... Increased age. *Abnormal body height. *History of cardiovascular disease (CV). *Abnormal ANP levels ... This can be either a premature atrial contraction or a premature impulse from the atrioventricular node. SVES should be viewed ... Premature ventricular contraction. References[edit]. *^ [1], Nickolls, Peter; Richard M. T. Lu & Kenneth A. Collins, "Apparatus ...
If they walk with walker at the age, they will most likely walk with a walker or crutches after the procedure, though it ... History of premature birth; if born at full term, child must have typical signs of spastic diplegia ... Rhizotomy is usually performed on the pediatric spastic cerebral palsy population between the ages of 2 and 6, since this is ... In September 2008, a SDR was performed that 'closed the gap' on concerns regarding age of the patient in SDR: Columbia- ...
"The endothelium abridges insulin resistance to premature aging". Journal of the American Heart Association. 2 (3): e000262. doi ...
These EEG findings are similar to premature aging. According to one review of the literature, if the developmental stage of ... It has been estimated by some that if the age at which people started drinking could be delayed to age 20, there would be a 50 ... Age and genetic factors influence the risk of developing alcohol-related neurotoxicity.[50] Adolescence, especially early ... College students have been found to be more likely to binge drink than their same age peers who were not enrolled in college. ...
Overall, excess or deficiency in the calciferol system appear to cause abnormal functioning and premature aging.[5][6][7][8] ... Keisala, T; Minasyan, A; Lou, YR; Zou, J; Kalueff, AV; Pyykkö, I; Tuohimaa, P (2009). "Premature aging in vitamin D receptor ... Tuohimaa, P (2009). "Vitamin D and aging". The Journal of Steroid Biochemistry and Molecular Biology. 114 (1-2): 78-84. doi: ... Manya, H.; Akasaka-Manya, K.; Endo, T. (2010). "Klotho protein deficiency and aging". Geriatrics & Gerontology International. ...
... premature aging; prooxidant and antioxidant alterations that lead to cellular damage; cardiopulmonary disease; hypertension; ...
Fisher GJ, Wang ZQ, Datta SC, Varani J, Kang S, Voorhees JJ (November 1997). "Pathophysiology of premature skin aging induced ... causes skin aging (but at a slower rate than UVA).[citation needed] stimulates the production of new melanin, which leads to an ... The study suggests that the melanoma risk is linked more closely to total exposure than it is to the age at which an individual ... Overexposure to ultraviolet radiation is known to cause skin cancer, make skin age and wrinkle faster, mutate DNA, and impair ...
2009). "Evidence of premature immune aging in patients thymectomized during early childhood". J Clin Invest. 119 (10): 3070- ... "Evidence of premature immune aging in patients thymectomized during early childhood". JCI. Retrieved 2012-06-11. Bredenkamp, ... With aging the thymus slowly shrinks, eventually degenerating into tiny islands of fatty tissue. By the age of 75 years, the ... However, there is evidence of premature immune aging in patients thymectomized during early childhood. Other indications for ...
"Evidence for premature aging in a Drosophila model of Werner syndrome". Experimental Gerontology. 127: 110733. doi:10.1016/j. ... melanogaster is also used in studies of aging. Werner syndrome is a condition in humans characterized by accelerated aging. It ... Mutations in the D. melanogaster homolog of WRN also cause increased physiologic signs of aging, such as shorter lifespan, ... age, and geography". Evolution; International Journal of Organic Evolution. 55 (1): 205-9. doi:10.1111/j.0014-3820.2001.tb01286 ...
Premature puberty. Cancer. Cardiovascular disease in people with diabetes. Aging (C.elegans and crickets). A 2017 review and ...
"Pigmentation and Premature Aging Woes? New Japanese Line Has You Covered". Monsters & Critics. Retrieved 13 March 2015. ...
"Depression linked to premature birth". The Age. Melbourne. 4 May 2004. Archived from the original on 8 April 2009. Retrieved 16 ... Preterm birth, also known as premature birth, is the birth of a baby at fewer than 37 weeks gestational age. These babies are ... The physicians who specialize in the care of very sick or premature babies are known as neonatologists. In the NICU, premature ... a common occurrence among premature babies. The world's smallest premature boy to survive was born in February 2009 at ...
"Epigenetic inactivation of the premature aging Werner syndrome gene in human cancer". Proc. Natl. Acad. Sci. U.S.A. 103 (23): ... More than one kind of treatment is often used, depending on the stage of the cancer, the individual's overall health, age, ...
... may stop long bone growth in young people who are still growing.[7] Premature epiphyseal closure can occur in ... Risk factors for skeletal effects include older age, greater dosage and longer course of treatment. Most bone changes cause no ... Generally though, premature epiphyseal closure seems to be primarily related to: *high doses of isotretinoin beyond the ... Other rare side effects include hyperostosis, and premature epiphyseal closure, have been reported to be persistent. ...
Parent's age[edit]. Main articles: Advanced maternal age and Paternal age effect ... pre-mature births, and stillbirth. These complications not only may put the child at risk, but also the mother.[74] ... with the paternal age governing how many mutations are passed on. This is because, as humans age, male germ cells acquire ... and patent ductus arteriosus in offspring has been found to be correlated with advanced paternal age. Advanced paternal age has ...
Parent's age[edit]. Main articles: Advanced maternal age and Paternal age effect ... Exposure during the first eight weeks of development can also lead to premature birth and fetal death. These numbers are ... with the paternal age governing how many mutations are passed on. This is because, as humans age, male germ cells acquire ... and patent ductus arteriosus in offspring has been found to be correlated with advanced paternal age. Advanced paternal age has ...
"Genomic instability in laminopathy-based premature aging". Nat. Med. 11 (7): 780-5. doi:10.1038/nm1266. PMID 15980864. ZMPSTE24 ...
... may cause features of premature aging (see DNA damage theory of aging). LMNA has been shown to interact with: ALOX12 EMD NARF ... Sliwińska MA (2007). "[The role of lamins and mutations of LMNA gene in physiological and premature aging] Polish". Postepy ... Scaffidi P, Misteli T (April 2005). "Reversal of the cellular phenotype in the premature aging disease Hutchinson-Gilford ... "Genomic instability in laminopathy-based premature aging". Nat. Med. 11 (7): 780-5. doi:10.1038/nm1266. PMID 15980864. Tang K, ...
Mutations in lamin A (LMNA) cause Hutchinson-Gilford progeria syndrome, a dramatic form of premature aging. Mouse cells ... premature aging). Most of these symptoms develop after birth, typically during childhood or adolescence. Some laminopathies ... "Genomic instability in laminopathy-based premature aging". Nat. Med. 11 (7): 780-5. doi:10.1038/nm1266. PMID 15980864. Chen L, ... adequately repair DNA damages when A-type lamins are defective is likely responsible for some of the aspects of premature aging ...
Premature aging Restrictive dermopathy - A disease associated with extremely tight skin and other severe neonatal abnormalities ... "Genomic instability in laminopathy-based premature aging". Nat. Med. 11 (7): 780-5. doi:10.1038/nm1266. PMID 15980864. Yozef ...
Menopause before age 45 is considered premature in industrialised countries.[17] Like the age of menarche, the age of menopause ... The average age of menarche is approximately 12.5 years in the United States,[12] 12.7 in Canada,[13] 12.9 in the UK[14] and ... for ages 25 to 39.[21] Subsequently, the variability increases slightly for women aged 40 to 44.[21] ... The average age of menarche is 12-15.[5][11] They may occasionally start as early as eight, and this onset may still be normal. ...
"Runner's Face Story: Premature Aging From Being HyperAthletic". YouTube. October 10, 2011. Retrieved June 19, 2013. "Dr. Lam ...
These EEG findings are similar to premature aging. According to one review of the literature, if the developmental stage of ... It has been estimated by some that if the age at which people started drinking could be delayed to age 20, there would be a 50 ... College students have been found to be more likely to binge drink than their same age peers who were not enrolled in college. ... When the survey results were separated into age groups the findings were that 13 percent of 15-year-old's and 22 percent of 17- ...
... invalidity and old age; (4) premature death; (5) unemployment. These contingencies are not in practice adequately provided ...
At age seven Ruth began to write short verses and read any book she could get her hands on. Her favorite author was Jean ... Fulton loved his work and research, it eventually led to his premature death, as he acquired an unknown disease during one of ... Although Ruth Benedict's fascination with death started at an early age, she continued to study how death affected people ... September 17, 1948(1948-09-17) (aged 61). New York City, New York, U.S.. ...
Studies of premature aging syndromes might be helpful to acquire further clues to understand the molecular mechanisms ... Hutchinson-Gilford progeria syndrome (HGPS or progeria) is a genetic disease causing segmental premature aging in children, ... Aging affects all people and is a complex process involving both genetic and environmental factors in a way that is not yet ... Despite this, aged HGPS mice did not experience any neuropathological changes or alterations in gene expression. Hence, our ...
Symptoms of premature menopause are those typical of menopause and include vaginal dryness, hot flashes, cognitive changes, and ... Many factors can contribute to early menopause like premature ovarian failure, diseases, and hormonal problems. ... Premature or early menopause occurs when a woman enters menopause earlier than the age of 40. ... Premature ovarian failure affects about 1 out of every 1000 women from ages 15 to 29 and about 1 out of every 100 women aged 30 ...
Scientists have discovered a drug they believe can reverse the effects of premature aging and could extend human life by over a ... HGPS is a rare condition in which aging is hyper-accelerate and sufferers die of "old age" at around 12 years. ... He added: "It should be emphasized that we are not recommending rapamycin as an anti-aging medicine at this point. Safer ... HGPS causes a protein called progerin to build up in every cell of the body, causing them to age prematurely. ...
Yet, even the best anti-aging diet and pricey skin care products dont guarantee youll prevent premature aging. However, if ... you include this new plant extract into your anti-aging regime, you may just achieve the beautiful, ageless skin of your dreams ... aging aging gracefully anti-aging anti-aging products anti-aging skin care beauty 911 beauty dos and donts beauty myths beauty ... Yet, even the best anti-aging diet, fitness program, and pricey skin creams dont guarantee youll prevent premature aging. ...
It could possibly lead to premature aging. Researchers from the University of California at San Francisco examined the DNA of ... This finding is alarming because it suggests that soda may be aging us, in ways we are not even aware of. Yikes. How do sugar ... essentially making the body age faster while raising the risk for disease and early death. Says study author Dr. Elissa Epel: ... but this suggests that there is an invisible pathway that leads to accelerated aging, regardless of weight.... ...
Can GM take the ``old`` out of Oldsmobile?It`s going to try, as indicated by the appointment last week of Michael Losh to be general manager of Olds, GM`s upscale car division.Losh, 43, succeeds
... that heavy drinking and smoking are linked to physical signs of premature aging. This is the first ... Heavy Smoking, Drinking Tied to Premature Aging. By Traci Pedersen Associate News Editor ... Home » News » Heavy Smoking, Drinking Tied to Premature Aging. .fn{margin:-2px 0 0 0;font-size:90%!important}.time-read{color:# ... that heavy drinking and smoking are linked to physical signs of premature aging. ...
The pathogenesis of HGPS is studied intensively because the mechanisms of premature aging may lead to a better understanding of ... Hutchinson-Gilford progeria syndrome (HGPS) is a fatal disease characterized by premature aging in which young children fail to ... normal aging. In this issue of the JCI, Osmanagic-Myers and colleagues identify the cellular mechanisms that lead to vascular ...
... 22.02.2011. Endurance exercise may stop you looking and feeling old, it may even ... found that premature aging in nearly every organ in the body was completely prevented in mice that ran on a treadmill three ... CIHR »Canadian Light Source »DNA »brain aging »cellular powerhouses »endurance »exercise »health services »mitochondria » ... Further reports about: , CIHR , Canadian Light Source , DNA , brain aging , cellular powerhouses , endurance , exercise , ...
Of course the major reason of skin wrinkling is aging. Although aging cannot be prevented, we can control ... Read ,. Author: ... Skin Aging: How Your Lifestyle Affects Your Skin. 11th March 2010. For a few individuals, growing old could be a testament that ... And this is somewhat the rewarding half of aging- gaining a lot of experiences and growing wiser. However, there are also folks ... it cannot retain its perfect shape as we age. When we gain weight suddenly over a short p... Read ,. Author: jsocratous ...
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ComplicationsSyndromeOccursGeneticPrematurelyPhenotypeTelomeresPreventDysfunctionSignsTelomereCellularMiceProgeriaResearchersBiologicalVascularEffects of prematureAvoiding premature deathsSkinLead to prematureTreatmentsAffectsSymptoms of prematureAvoid prematurePromote prematureGeneImpairmentTypicallyKnown as prematureDefectsInfantFree radicals2018NormalCognitiveAntioxidantCohort studyRiskOxidative stressHGPSCardiovascular diseaseIncreasesMitochondrial functionMechanismsDegenerative diseasesOvarian reserveInfertilityCollagenProcessCONCLUSIONS
- The children with progeria die prematurely at a median age of 14.6 years, due to complications from cardiovascular disease and atherosclerosis. (ki.se)
- Hutchinson-Gilford progeria syndrome (HGPS or progeria) is a genetic disease causing segmental premature aging in children, with an approximated incidence of 1 in 20 million individuals. (ki.se)
- Studies of premature aging syndromes might be helpful to acquire further clues to understand the molecular mechanisms explaining how aging occurs. (ki.se)
- HGPS causes a protein called progerin to build up in every cell of the body, causing them to age prematurely. (redorbit.com)
- Just one misplaced letter out of billions in the genetic code was leading to the production of a toxic protein that makes cells age prematurely. (kuow.org)
- Frequently, however, a body that is aging prematurely sends a message to its owner that it is malfunctioning. (diagnose-me.com)
- This one in particular that we will be talking about today is for skin that is aging prematurely. (naturesgardencandles.com)
- Earlier studies had shown that mice lacking the Terc gene, which is key to DNA repair, have lower stem cell function and age prematurely, losing fertility and developing scaly skin, gray fur and shrunken, hunched bodies. (healthcanal.com)
- Hutchinson-Gilford progeria syndrome (HGPS) is a rare, fatal disease in which patients age prematurely. (cancer.gov)
- And, corrected age , which is how old your baby would be if born on his or her due date rather than prematurely. (mymonthlycycles.com)
- hence the look of prematurely aged skin. (vidaspas.com)
- CS-exposed mice and highly irradiated mice are predicted to be prematurely aged. (biomedcentral.com)
- Life expectancy is increasing in Europe, yet a substantial proportion of adults still die prematurely before the age of 70 years. (altmetric.com)
- He stressed that most of the teenagers who were premature babies did not have depression, and that the triggers for depression in those born prematurely were the same as for everyone else. (theage.com.au)
- Study of the pathological effects resulting from genetic deletion of all Pim kinase family members could provide important insight about cardiac mitochondrial biology and the aging phenotype. (nih.gov)
- Here we identify mtDNA deletions as a driving force behind the premature aging phenotype of mitochondrial mutator mice, and provide evidence for a homology-directed DNA repair mechanism in mitochondria that is directly linked to the formation of mtDNA deletions. (nih.gov)
- Typically, 3-month-old K5-CYLD C/S mice exhibit a phenotype characterized by alopecia and kyphosis, and, the histological examination reveals that transgenic mice show signs of accelerated aging in numerous organs such as skin, thymus, pancreas, liver and lung. (aging-us.com)
- The mtDNA mutator mice have high levels of point mutations and linear deletions of mtDNA causing a progressive respiratory chain dysfunction and a premature aging phenotype. (diva-portal.org)
- These findings refute recent claims that circular mtDNA molecules with large deletions are driving the premature aging phenotype. (diva-portal.org)
- If shortened or degraded, these end caps-called telomeres-make it harder for cells to regenerate, essentially making the body age faster while raising the risk for disease and early death. (glamour.com)
- They took blood samples from more than 5,000 women aged 42 to 69 and measured the length of tiny pieces of DNA called telomeres. (health.com)
- Although mouse models have provided insight into the role of telomeres in premature aging, they do not recapitulate all human symptoms. (biologists.org)
- It is thought that aging occurs when the telomeres become too short for DNA replication and cell division to proceed normally. (medindia.net)
- Studies on normal aging have identified a molecular circuit in which the dysfunction of telomeres caused by cellular aging activates the TP53 gene. (spandidos-publications.com)
- open source) showing that telomeres, sequences of DNA on the end of chromosomes taken as a marker of biological aging, are, on average, 356 base pairs shorter in study participants who slept for fewer than five hours per night than in those who slept for seven hours. (dericbownds.net)
- It is notable, then, that the reduced longevity and fitness of mTR-/- mice were not manifest until the mouse telomeres had substantially shortened to lengths more typical of those found in aged human tissues. (europeanmedical.info)
- In Children with dyskeratosis congenita, a rare condition that leads to premature aging, genetic mutations impair a key enzyme called telomerase that builds up the tips of our chromosomes, known as telomeres. (childrenshospital.org)
- When cells aren't able to maintain their telomeres, the chromosomes become vulnerable to all kinds of damage, and the cell "ages" more quickly and stops dividing. (childrenshospital.org)
- Yet, even the best anti-aging diet, fitness program, and pricey skin creams don't guarantee you'll prevent premature aging. (sheknows.com)
- There is no treatment that can reverse or prevent premature menopause. (medicinenet.com)
- The interplay of Spns1 and Atp6v0ca genes may prevent Premature ageing, signaling the need for a healthy lifestyle. (medindia.net)
- Pim kinases prevent premature cardiac aging and maintain a healthy pool of functional mitochondria leading to efficient cellular energetics. (nih.gov)
- The researchers concluded that the study findings provide further evidence to support the importance of prevention and treatment of obesity, type 2 diabetes, and high blood pressure in teens to help delay or prevent premature aging of their blood vessels. (labtestsonline.org)
- That's why we turned to world-renowned integrative-medicine expert Andrew Weil, M.D., author of Healthy Aging: A Lifelong Guide to Your Physical and Spiritual Well-Being (Knopf, 2005) for advice on how to prevent and reduce harmful inflammation throughout the body. (shape.com)
- The findings, published in the August issue of Arthritis and Rheumatism , suggest that innovative treatment approaches could aim to prevent premature aging of immune cells. (medindia.net)
- This study suggests cell-targeted treatments could be developed to prevent this premature immune aging. (medindia.net)
- To prevent premature aging, you need to avoid these top ten causes. (thehealthsuccesssite.com)
- Fortunately though there are natural ways for you to prevent premature aging and natural ways for you to stay young looking longer. (arganoilshop.com)
- Prevent premature aging with these simple and useful tips! (arganoilshop.com)
- There are many ways to prevent premature aging of the skin , from diet and lifestyle adjustments to topical preparations. (greenwichgynecology.com)
- Actually, to prevent aging can not be done by humans, but humans could try to slow down the ages, so that he seemed ageless. (thealthbenefitsof.com)
- Well, how to prevent premature aging? (thealthbenefitsof.com)
- There is a list of top nutritious foods to prevent premature aging. (thealthbenefitsof.com)
- Eating a diet high in antioxidants can help prevent premature aging. (healthline.com)
- Metabolic dysfunction consistent with premature aging results from deletion of Pim kinases. (nih.gov)
- From a clinical perspective, most DM symptoms are interpreted as a result of an accelerated aging (cataracts, muscular weakness and atrophy, cognitive decline, metabolic dysfunction, etc.), including an increased risk of developing tumors. (frontiersin.org)
- From this point of view, DM1 could be described as a progeroid syndrome since a notable age-dependent dysfunction of all systems occurs. (frontiersin.org)
- Satellite cell dysfunction seems to be a common feature of both age-dependent muscle degeneration (sarcopenia) and muscle wasting in DM and other muscle degenerative diseases. (frontiersin.org)
- Dr. Kelesidis and his team will use the grant to investigate whether a novel mitochondrial antioxidant (MitoQ), and another potent antioxidant (4F) can help to stop the progression of T-Cell dysfunction associated with aging. (prurgent.com)
- With financial support from the Campbell Foundation, we will explore whether novel antioxidants improve dysfunction of immune cells that contribute to overall HIV-related aging" said Dr. Kelesidis. (prurgent.com)
- As an analogy of the mechanism in natural aging, we described a hypothetical mechanism of premature aging in WS: telomere dysfunction induced by WRN mutation causes multiple premature aging phenotypes of WS, including shortened cellular lifespan and inflammation induced by ROS, such as diabetes mellitus. (spandidos-publications.com)
- This perspective review focused on a hypothetical cascade beginning with telomere dysfunction caused by WRN gene mutation leading to multi-phenotypes of premature aging and an abnormal profile of tumors. (spandidos-publications.com)
- Thus, the mitochondrial free radical theory of aging [ 1 ] postulates that organisms age due to the accumulation of DNA damage and mutations in the mitochondrial DNA, leading to mitochondrial and eventually cellular dysfunction. (hindawi.com)
- A new Danish study confirms what many may already suspect: that heavy drinking and smoking are linked to physical signs of premature aging. (psychcentral.com)
- For the study, the researchers evaluated the data of more than 11,500 adults, whose heart health and visible aging signs were tracked for an average of 11.5 years as part of the Copenhagen City Heart Study. (psychcentral.com)
- They were also checked for four signs of aging that have been linked to a greater risk of cardiovascular ill health and/or death. (psychcentral.com)
- An individual who shows signs of premature aging could be at an increased risk for disease found in older people and could also undergo emotional issues that affect mental health. (medindia.net)
- Most people, deep down, would probably love to reduce the signs of premature aging but cannot continuously afford to keep buying expensive, and sometimes questionably, effective anti aging creams and lotions. (a1articles.com)
- Retinoids are derivatives of Vitamin A that are used topically or even orally to treat a variety of skin concerns like acne, aging signs, sun spots and even certain cancers. (a1articles.com)
- Using bioinformatics tools, Reversade and his team analyzed DNA samples collected worldwide from patients who, at a young age, displayed signs of premature aging. (skininc.com)
- But previous studies by Dr. de Vallejo of young adults with rheumatoid arthritis indicated that a certain population of cells present in the joint synovial fluid and blood displayed telltale signs of abnormal cell division and premature aging. (medindia.net)
- The follow-up data included signs of spontaneous puberty, age at menarche, the use of hormone replacement therapy, pregnancies, and information about pubertal or postpubertal serum FSH levels. (helsinki.fi)
- In our mid to late 20's, the beginning signs of the normal aging process start. (lathene.com)
- and, importantly, they show signs of premature aging from an early age. (aging-us.com)
- There are certain indications that a woman is at high risk for premature birth, such as cervical insufficiency , but many women go into preterm labor without having exhibited clinical warning signs. (abclawcenters.com)
- This super food is able to reduce the signs of premature aging and and you will always look younger. (thealthbenefitsof.com)
- Nuts are the best source of omega 3 which is great for improving heart health and eliminate signs of premature aging. (thealthbenefitsof.com)
- Among the first mouse models to show multiple signs of accelerated aging was the telomerase knockout mouse. (europeanmedical.info)
- Many so-called signs of aging like shrinking in height, joint problems, as well as premature graying hair can be helped when you have good digestion. (regenerationville.com)
- Many signs of aging can be moderated through the environment and your diet, as well as by reducing inflammation-promoting activities, such as smoking and sun exposure ( 13 ). (healthline.com)
- Check out this month's March Madness skin care special that offers a discount price on the Revox ™ 7 and D-E-J eye cream ™ products that can help eliminate signs of aging. (mooresvilledermcenter.com)
- Telomere shortening occurs in the normal process of aging, and mutations in telomerase, the enzyme that maintains telomere length, can accelerate this process. (biologists.org)
- Peripheral lymphocyte telomere lengths are used as biomarker and these are unreliable markers of aging. (rechargebiomedical.com)
- Using wearable-derived TST, we showed that insufficient sleep was associated with premature telomere attrition. (dericbownds.net)
- The intensity of the green signal is one indicator of telomere length, which is a measure of cellular 'aging' and determines how many times a cell can divide. (childrenshospital.org)
- These mice were genetically engineered to age faster due to a defect in a gene for polymerase gamma (POLG1) that alters the repair system of their mitochondria - the cellular powerhouses responsible for generating energy for nearly every cell in the body. (innovations-report.com)
- This review aims to describe the cellular, molecular and macrostructural processes involved in the muscular degeneration seen in DM patients, highlighting the similarities found with muscle aging. (frontiersin.org)
- Suppressed NRF2 activity and oxidative stress recapitulate HGPS aging defects, whereas reactivation of NRF2 activity in HGPS patient cells reverses cellular aging defects and restores in vivo viability of MSCs in an animal model. (cancer.gov)
- The resultant p53 suppresses cell growth and induces a shorter cellular lifespan, and also compromises mitochondrial biogenesis leading to the overproduction of reactive oxygen species (ROS) causing multiple aging phenotypes. (spandidos-publications.com)
- Although much is known about patterns in fetal development at the cellular and molecular level, we do not yet have molecular tests that can reliably determine the gestational age of an individual fetus. (abclawcenters.com)
- The study, published today in the prestigious science journal Proceedings of the National Academy of Sciences (PNAS), found that premature aging in nearly every organ in the body was completely prevented in mice that ran on a treadmill three times a week for five months. (innovations-report.com)
- We found that natural aging of WT mice is marked with increased Cdc42 activity in various tissues. (pnas.org)
- Interestingly, an examination of Cdc42 activity in WT adult mice of various ages reveals that the relative Cdc42-GTP level of older animals is significantly higher than that of younger ones in diverse tissues, including heart, brain, lung, liver, bone marrow, spleen, and kidney ( Fig. 1 A and data not shown), raising the possibility that increased Cdc42 activity is involved in the normal aging process. (pnas.org)
- Increased Cdc42 activity in the course of natural aging in mice and the effects of Cdc42GAP gene targeting on the growth, bone structure, life span, and fertility period of adult mice. (pnas.org)
- A ) Normal aging in mice is associated with increased Cdc42 activity. (pnas.org)
- Here, María Cayuela's group show that telomerase-deficient zebrafish demonstrate the hallmark features of premature aging in the first generation, in contrast with mice, which have to be bred for several generations. (biologists.org)
- Premature aging in behavior and immune functions in tyrosine hydroxylase haploinsufficient female mice. (ucm.es)
- The aim of the present work was to analyze whether adult TH-HZ female mice presented the impairment of behavioral traits and immunological responses that occurs with aging and whether they had affected their mean lifespan. (ucm.es)
- Although these differences between TH-HZ and WT, in general, decreased with aging, this premature immunosenescence and impairment of behavior of TH-HZ mice was accompanied by a shorter mean lifespan in comparison to WT counterparts. (ucm.es)
- In conclusion, haploinsufficiency of th gene in female mice appears to provoke premature aging of the regulatory systems affecting mean lifespan. (ucm.es)
- Chronological age versus predicted age for sham- and CS-exposed mice from E-MTAB-5281, E-MTAB-5280 and E-MTAB-7444 datasets. (biomedcentral.com)
- Age predictions of samples from an independent public dataset (GSE18344) where CD-1 mice where exposed to different daily doses of CS over 5 months. (biomedcentral.com)
- These mice express the transgene in different organs, including those considered to be more susceptible to aging, such as skin and thymus. (aging-us.com)
- Over-activation of the NF-κB pathway, along with hyperactivation of Akt, JNK and c-Myc, and chronic inflammation, appear as the mechanisms responsible for the premature aging of the K5-CYLD C/S mice. (aging-us.com)
- Random point mutations with major effects on protein-coding genes are the driving force behind premature aging in mtDNA mutator mice. (diva-portal.org)
- The reduced-longevity and premature-aging phenotypes of mTR-/- mice are even more pronounced when combined with a deficiency in WRN (Chapter 3), the gene that is defective in the human premature-aging disorder, Werner syndrome (WS) (148). (europeanmedical.info)
- The fact that the basic mechanisms involved in the aging process are believed to be universal allows the use of different model systems, from the simplest eukaryotic cells such as fungi to the most complex organisms such as mice or human. (hindawi.com)
- Hutchinson-Gilford progeria syndrome (HGPS) is a fatal disease characterized by premature aging in which young children fail to thrive and adolescents die from myocardial infarction or stroke. (jci.org)
- In Hutchinson-Gilford progeria, children as young as 1 to 2 start developing a host of dramatic symptoms, and they die at an average age of 14. (news-medical.net)
- Sam Berns, 15, who has the very rare premature-aging disease progeria, plays the drums in his high school's marching band. (kuow.org)
- Children with progeria have small fragile bodies and can weigh just a third of a typical child their age. (kuow.org)
- Using a new progeria-on-a-chip model, investigators from Brigham and Women's Hospital, led by João Ribas, PhD candidate, and Ali Khademhosseini, PhD, of the Biomaterials Innovation Research Center, have developed a way to recapitulate blood vessel dynamics to better understand vascular disease and aging. (phys.org)
- Researchers are expected to start looking at whether the drug could be used more widely, after similarities between HGPS and the normal aging process were uncovered. (redorbit.com)
- The researchers followed the teens, whose average age was approximately 18 when the study began, for five years. (labtestsonline.org)
- These women are considered to suffer from premature ovarian aging (POA), a clinical term coined by CHR researchers. (centerforhumanreprod.com)
- Recently, researchers have been able to generate induced pluripotent stem cells from patients with HGPS to better understand the mechanisms of aging and look for new treatments. (phys.org)
- Even when the researchers considered the risks for premature births - lower socio-economic class, the mother's age when she gave birth, or whether she smoked - it still did not explain the link between premature births and depression. (theage.com.au)
- The findings needed to be confirmed before researchers could look at whether early intervention would help to reduce the risk of premature babies. (theage.com.au)
- Researchers in the College of Nebraska in Omaha, and also the College of California in North Park, partnered for more information about how exactly chronic Aids infection affects aging. (unitedhealthsales.com)
- This new study adds to the evidence of earlier studies showing that the biological processes that precede heart attacks and cardiovascular disease begin in childhood, although they don't generally cause symptoms or lead to disease until middle age or later. (labtestsonline.org)
- Chronological age and biological age not the same. (diagnose-me.com)
- How you look is sometimes an indicator of you biological age, but appearances often can be deceptive. (diagnose-me.com)
- A study performed on biological markers showed that there was more aging in people who suffered from certain conditions. (thehealthsuccesssite.com)
- You might be in your thirties or forties, but the age of your biological markers can be a decade or more older. (thehealthsuccesssite.com)
- Here is the abstract of their article, titled "Digital phenotyping by consumer wearables identifies sleep-associated markers of cardiovascular disease risk and biological aging. (dericbownds.net)
- All biological organisms share a universal feature called aging. (biomedcentral.com)
- The outcomes from the research, which involved using a highly accurate biomarker to determine biological aging, are printed in Molecular Cell. (unitedhealthsales.com)
- Results claim that Aids infection results in a typical advance in biological aging of four.nine years, connected having a 19% elevated chance of mortality. (unitedhealthsales.com)
- Risk factors for accelerated early vascular (blood vessel) aging also included male sex and non-white race. (labtestsonline.org)
- Like obesity, type 2 diabetes and high systolic blood pressure can be improved with continued evaluation and treatment of these conditions to reduce risk of vascular aging. (labtestsonline.org)
- However, the impact of these biomechanical strains on aging and vascular diseases has been challenging to study in the lab as most models fail to mimic the biomechanics that cells experience in the body. (phys.org)
- The team found that cells derived from HGPS donors but not from healthy donors showed an exacerbated response to biomechanical strain, with an increase in markers of inflammation, which are strongly associated with vascular disease and aging. (phys.org)
- Vascular diseases and aging are intimately linked yet rarely studied in an integrated approach," the authors write. (phys.org)
- Gaining a deeper understanding of the molecular pathways regulating inflammation during vascular aging might pave the way for new strategies to minimizing cardiovascular risk with age. (phys.org)
- In conclusion, our study shows that the adult survivors after HSCT in young age are at risk of early reproductive and vascular aging and frailty. (helsinki.fi)
- Scientists have discovered a drug they believe can reverse the effects of premature aging and could extend human life by over a decade. (redorbit.com)
- You should also keep in mind that a healthy diet can also considerably lessen the effects of premature aging. (thejoyofwellness.net)
- Restricting sales of tobacco products to people 21 and older could keep 11,000 Michiganders from starting to smoke, potentially avoiding premature deaths in two-thirds of that population, according to a University of Michigan study. (medicalxpress.com)
- However, if you include a new plant extract into your anti-aging regime, you may just achieve the beautiful, ageless skin of your dreams. (sheknows.com)
- To ensure your vitamin D (sunshine vitamin) intake, you supplement with low-cost cholecalciferol (vitamin D3) as well as ingest foods (e.g. salmon, mushrooms) rich in this critical hormone-vitamin rather than subjecting your skin to the sun's damaging age-accelerating rays. (sheknows.com)
- Furthermore, those unsightly brown and tan age spots that occur on exposed areas of the skin are caused by accumulated sun exposure over many years. (sheknows.com)
- Unless you never the leave the house without being slathered in high sun protection factor (SPF) sunscreen or make-up with a high SPF, ultraviolet radiation is aging your skin (not to mention increasing your risk of skin cancer). (sheknows.com)
- Since about 80 percent of our lifetime accumulated sun exposure is incidental, Polypodium extract represents a breakthrough strategy in the form of a dietary supplement that can help guard your skin from accelerated aging. (sheknows.com)
- Of course the major reason of skin wrinkling is aging. (articlealley.com)
- Many things cause our skin to age. (scoop.it)
- Natural anti aging tips that will actually make a difference to your skin aren't a myth! (scoop.it)
- At night, skin goes into a renewal state," says Jeannette Graf, M.D., an assistant professor of dermatology at Mount Sinai Medical Center in New York and author of Stop Aging, Start Living . (lifescript.com)
- Not only does skin repair itself, but there's also a difference in its pH and circulation so anti-aging products penetrate better. (lifescript.com)
- Many cleansers have anti-aging ingredients, but they're typically not in high enough concentrations or in contact with your skin long enough to provide significant results," says Dee Anna Glaser, M.D, professor of dermatology at St. Louis University School of Medicine. (lifescript.com)
- Most of these diseases, called progeroid syndromes, share physiological symptoms characterized by the appearance of accelerated aging, such as skin disorders, loss of hair, skeletal and dental abnormalities and cardiovascular complications. (news-medical.net)
- It helps to neutralize the free radicals that are responsible for aging your skin. (a1articles.com)
- Chronic inflammation can negatively affect your health and even accelerate your skin's aging. (shape.com)
- Their findings not only suggest that increasing levels of the PYCR1 protein could reverse conditions that cause fast aging and wrinkly skin but also provide insight into how some unexpected genes help maintain youthful skin. (skininc.com)
- Since skin and bone contain high levels of the PYCR1 protein under normal circumstances, developing therapies that could increase the activity of the PYCR1 protein could possibly reverse the process of aging in affected individuals or slow it down in normal people. (skininc.com)
- We are excited by these findings of Bruno and colleagues, which open up new possibilities in the field of aging and skin research,' added Birgit Lane, PhD, a skin biologist and executive director of IMB, one of the research institutes sponsored by Singapore's A*STAR, or Agency for Science, Technology and Research. (skininc.com)
- Vitamin C is considered as a kind of important nutrient to affect the aging of skin. (lookchem.com)
- The adequate supplementation of vitamin C can not only whiten the skin, but also resist aging. (lookchem.com)
- Aging happens to all types of skin, in any stage of life, and it could be experienced by both men and women. (naturesgardencandles.com)
- They also contribute to anti aging, brightening and moisturizing the skin, and may help with acne issues. (naturesgardencandles.com)
- Alert: Your address affects your risk for skin damage and premature aging. (shape.com)
- Add zip code to the list of things that impact how old your skin looks: A recent study ranked 50 U.S. cities to determine where residents are the most at risk for skin damage and premature aging by 2040 (sounds far away, but that's only 24 years from now). (shape.com)
- And aging issues aside, stress also increases the amount of oil in your skin, upping the likelihood of breakouts. (shape.com)
- Both lead to free radical damage, a major cause of aged skin, irritation, and inflammation. (shape.com)
- Children born with HGPS appear normal, but they experience growth retardation and show symptoms of accelerated aging -- namely hair loss, skin wrinkling, and fat loss -- around the first year of age. (bio-medicine.org)
- While you cannot totally eliminate the natural aging process, the earlier you implement good skin choices, the more you minimize the effects. (lathene.com)
- Also, the skin around the eye area is very thin and needs extra anti-aging care. (lathene.com)
- Dehydration in the skin weakens its defense and creates skin sensitivity, irritation, and premature aging. (vidaspas.com)
- Lack of collagen in the body can directly affect the health of your nails, skin elasticity, bones and joints , leading to premature aging and making one look much older than their current age. (thejoyofwellness.net)
- Both spinach and cabbage contain large amounts of vitamin C. Consuming salads with vegetables will make your skin beautiful and radiant, preventing premature aging. (thejoyofwellness.net)
- About 70% of the skin aging process depends on the amount of sunlight your skin is exposed to. (beingabeauty.com)
- Premature fine lines that usually appear on areas where the skin is very thin, such as on the sides of the eyes or smile lines and above the upper lip, are caused by smoking. (beingabeauty.com)
- As we age, the underlying collagen network, muscles, and bones that support our skin gradually weaken and atrophy. (lavie-organique.com)
- Antioxidants known as glucosinolates may also play a protective role in skin aging ( 16 ). (healthline.com)
- Other antioxidants in rutabagas may also play a protective role in skin aging. (healthline.com)
- Ultraviolet A (UVA) is the type of solar radiation most associated with skin aging (photoaging). (mayoclinic.org)
- Everybody's skin ages differently. (luxebotanics.com)
- Scrubbing irritates the skin and accelerates aging. (mooresvilledermcenter.com)
- And now a new study has found that slurping the sweet stuff may affect our bodies in yet another way: It could possibly lead to premature aging. (glamour.com)
- Age-defying and anti-wrinkling treatments for common disorders related to aging may also benefit from sustaining proline metabolism. (skininc.com)
- For people who suffer from the effects of accelerated aging after undergoing treatments such as radiation that damage DNA or who suffer from acute radiation poisoning these findings hint at novel therapies. (healthcanal.com)
- Premature ovarian failure affects about 1 out of every 1000 women from ages 15 to 29 and about 1 out of every 100 women aged 30 to 39. (medicinenet.com)
- however, it is not known if age at exposure affects the risk of adverse outcome. (escholarship.org)
- Many patients will have no symptoms of premature ovarian aging or diminished ovarian reserve, so often it's discovered accidentally by one of their treating physicians. (centerforhumanreprod.com)
- With rich contents of antioxidants, vitamin E, and essential fatty acids, argan oil nourishes every body part and helps avoid premature aging. (arganoilshop.com)
- Alpha-lipoic acid (ALA) is a unique, vitamin-like antioxidant that can combat radiation sickness, repair damaged livers, treat diabetes and diabetes-related conditions (polyneuropathy) and protect against oxidative processes that promote premature aging and degenerative diseases. (nutritionreview.org)
- Defects in the Spns1 (Sphingolipid Transporter 1 (putative)) gene induce degradation and premature aging while corresponding defects in atp6v0ca gene was found to suppress the effects of Spns1(Sphingolipid Transporter 1 (putative)) gene. (medindia.net)
- This perspective review focused on the Werner syndrome (WS) by addressing the issue of how a single mutation in a WRN gene encoding WRN DNA helicase induces a wide range of premature aging phenotypes accompanied by an abnormal pattern of tumors. (spandidos-publications.com)
- To evaluate the relationship between preterm premature rupture of membranes (PPROM) and cognitive impairment in 5-year-old children born very preterm. (nih.gov)
- Among the 1051 children followed up to age 5 years, the mean Mental Processing Composite score was 93.6 ± 19.7, and 13.3% of the children (140 of 1051) had cognitive impairment. (nih.gov)
- Aging is accompanied by impairment in the nervous, immune, and endocrine systems as well as in neuroimmunoendocrine communication. (ucm.es)
- FINDINGS: We enrolled 306 children with neurological impairment, 9912 survey controls, and 22 873 age-matched participants from the general population, and followed up the cohorts between June 1, 2001, and Aug 31, 2018. (ox.ac.uk)
- The overall risk of death adjusted for age and sex was higher in children with neurological impairment compared with controls (HR 4·24, 95% CI 2·26-7·94, p=0·002). (ox.ac.uk)
- Now we be worried about illnesses associated with aging, like coronary disease, neurocognitive impairment and liver problems. (unitedhealthsales.com)
- Women with premature ovarian failure may still occasionally have menstrual periods, but they typically experience infertility . (medicinenet.com)
- In popular culture, notions of premature aging syndromes are typically expressed in the stories of fanciful characters like Benjamin Button, who ages backward out of his frail condition and emerges as a strapping, healthy middle-aged man. (news-medical.net)
- JIA is typically treated with broad-spectrum drugs such as steroids and biologics that essentially paralyze the entire immune system, but only a third of the cells are affected and their abnormality seems to be premature aging, rather than autoimmune activity," he noted. (medindia.net)
- Accelerated cardiovascular disease also ensues, which typically causes death around age 12. (bio-medicine.org)
- While combination antiretroviral therapy can enable individuals with Aids to savor a lot more many years of existence compared to what they might formerly have expected, exactly the same patients seem to be vulnerable to losing typically five years of existence because of premature aging. (unitedhealthsales.com)
- While the process of aging is normal, when this process is advanced, resulting in symptoms that are normally identified in old age but now being identified at an early stage, it is known as premature ageing. (medindia.net)
- Werner syndrome and Bloom syndrome result from defects in the RecQ helicases Werner (WRN) and Bloom (BLM), respectively, and display premature aging phenotypes. (pnas.org)
- This may open the door for therapeutic interventions that correct for these DNA defects and possibly restore normal lifespan in premature aging patients," Mekhail said. (healthcanal.com)
- Thus, understanding how progerin causes the defects observed in HGPS should, in addition to identifying therapeutic targets, provide insights into the natural aging process. (cancer.gov)
- The less a premature infant weighs at birth, the more profound the growth disturbance will be . (who.int)
- Results through age 5 years from the Infant Health and Development Program. (semanticscholar.org)
- Free radicals destroy cells in the body and make the body age earlier than it should. (arganoilshop.com)
- It is important then to nurture antioxidants and to get rid of free radicals because antioxidants mean anti-aging. (arganoilshop.com)
- The team conducted a national survey of 800 people ages 14-24 in September 2018 via SMS text message. (medicalxpress.com)
- The pathogenesis of HGPS is studied intensively because the mechanisms of premature aging may lead to a better understanding of normal aging. (jci.org)
- Without the diseases of premature aging, normal human life expectancy is estimated to be 120 years. (diagnose-me.com)
- If premature aging can be halted and normal function reestablished, then people not only will live longer but also will have a higher quality of life with the elimination of pain. (diagnose-me.com)
- The longer the individuals had had fibromyalgia, the greater the gray matter loss, with each year of fibromyalgia being equivalent to 9.5 times the loss in normal aging. (jneurosci.org)
- While the current study doesn't pertain directly to normal aging in healthy individuals, Fuchs says future studies could shed light on ways to mitigate its negative effects. (healthcanal.com)
- And what works for premature aging could also be applied to normal aging. (healthcanal.com)
- Progerin is thought to also be important in normal aging since the protein accumulates in cells as people get older. (cancer.gov)
- The normal process of reproductive aging varies considerably among women. (centerwatch.com)
- Within the context of normal female reproductive aging, as already outlined, large individual variation exists in the age at which the various reproductive events occur. (centerwatch.com)
- These won't protect you if you intend to spend hours under the noon sun, but they will provide anti-aging action during a normal day's exposure. (a1articles.com)
- In the present study refraction and keratometric values of premature babies at 40 weeks' postconceptional age (PCA) were compared to normal term babies at the same age to determine if there were inborn refractive changes presenting as early as 40 weeks of age. (bmj.com)
- Measures of thrombophilia-hypofibrinolysis were obtained in 153 patients with CVD ≤ age 45 compared to 110 healthy normal controls and 110 patients who had venous thromboembolism (VTE without CVD). (onlinejacc.org)
- Premature birth (before 37 full weeks of gestation) leads to disturbance in the normal rate of growth. (who.int)
- I had an MRI and they said I have volume loss in my brain and not normal for my age. (justanswer.com)
- Some prescription anti-aging products may burn or sting as a normal part of the initial application process. (mooresvilledermcenter.com)
- The association between SGA/AGA and neurologic status on cognitive outcomes at each age was also examined. (rti.org)
- There were no differences between SGA and AGA children in cognitive or neurologic outcomes at any age when grouped by birth weight. (rti.org)
- There was, nevertheless, a significant effect of SGA on cognitive outcome independent of neurologic status at all ages except 3 years. (rti.org)
- Cognitive development at age 5 years was assessed using the Mental Processing Composite score of the Kaufman-Assessment Battery for Children. (nih.gov)
- Impaired cognitive performance in premature newborns with two or more surgeries prior to term-equivalent age. (escholarship.org)
- Neither the number of surgeries after TEA nor sedation for MRI was associated with cognitive outcome.More than one surgery prior to TEA is independently associated with impaired cognitive performance in premature newborns. (escholarship.org)
- A health restoration program could include many modern laboratory assessments such as testing for antioxidant status, digestive analysis, immune system function, hormone status, circulation, and other aging markers. (diagnose-me.com)
- Melatonin is an antioxidant that delays the neurodegenerative and inflammatory processes related to aging. (directtextbook.com)
- Purple foods are colored by a pigment called anthocyanin, a strong and protective antioxidant which can help reduce the risk of cancer, help improve memory and assist with healthy aging. (sheknows.com)
- We analysed data from 264,906 European adults from the EPIC prospective cohort study, aged between 40 and 70 years at the time of recruitment. (altmetric.com)
- Premature mortality in children aged 6-9 years with neurological impairments in rural Kenya: a cohort study. (ox.ac.uk)
- The risk of premature ovarian failure risk increases in women who have relatives with the condition. (medicinenet.com)
- Analysis of drinking and smoking patterns revealed a consistently greater risk of looking older than one's true age and developing arcus corneae, earlobe creases, and xanthelasmata among those who smoked and drank heavily. (psychcentral.com)
- NaturalHealth365) A stunning two out of three American adults are overweight or obese, putting them at risk for premature aging and life-threatening conditions like, diabetes and heart disease. (naturalhealth365.com)
- Recent research suggests that obesity, type 2 diabetes , and high blood pressure increase teenagers' risk of premature aging of blood vessels (before age 55 for males and before age 65 for females). (labtestsonline.org)
- These events could occur at an earlier age than teens without risk factors. (labtestsonline.org)
- Ryder added that obesity should be treated as aggressively as type 2 diabetes because it has the same increased risk for premature aging of the blood vessels, a precursor to cardiovascular diseases in adulthood. (labtestsonline.org)
- The American Diabetes Association recommends that healthcare providers screen overweight children for diabetes starting at age 10 or at the onset of puberty if the children have two or more additional risk factors, using a fasting blood glucose test , hemoglobin A1c , or 2-hour oral glucose tolerance test . (labtestsonline.org)
- We developed and validated models for bronchopulmonary dysplasia risk at sixpostnatal ages usinggestational age, birth weight, race and ethnicity, sex, respiratory support, and FIO 2, and examined the models using a C statistic (area under the curve). (rti.org)
- Unprotected exposure to the sun's rays can undo even the best skincare routine and increase your risk of cancer, early aging and many other problems. (a1articles.com)
- Aim: The aim of this study is the research and analysis of the major modifiable risk factors for premature ageing. (alliedacademies.org)
- Older age at HSCT and total body irradiation and busulfan-based conditionings were risk factors for early ovarian aging. (helsinki.fi)
- Leukemia survivors with previous cranial radiotherapy or transplanted after disease relapse were at high risk of premature ovarian failure. (helsinki.fi)
- 4- 22 The risk of myopia increases in the presence of ROP, and its magnitude increases with a decrease in the age of prematurity and an increase in severity of the residua of ROP. (bmj.com)
- We sought to estimate the joint and relative contributions of tobacco smoking, hypertension, obesity, physical inactivity, alcohol and poor diet towards risk of premature death. (altmetric.com)
- Flexible parametric survival models were used to model risk of death conditional on risk factors, and survival functions and attributable fractions (AF) for deaths prior to age 70 years were calculated based on the fitted models. (altmetric.com)
- While smoking remains the predominant risk factor for premature death in Europe, poor diet, overweight and obesity, hypertension, physical inactivity, and excessive alcohol consumption also contribute substantially. (altmetric.com)
- This study estimated the risk of premature mortality in children with neurological impairments and identified risk factors and causes of death. (ox.ac.uk)
- INTERPRETATION: The risk of premature mortality was higher in children diagnosed with neurological impairments compared with the general population and was increased by developmental delay and severe malnutrition. (ox.ac.uk)
- Since oxidative stress has been implicated in HGPS and aging, the scientists decided to examine the status of NRF2 in HGPS cells. (cancer.gov)
- HGPS is a rare condition in which aging is hyper-accelerate and sufferers die of "old age" at around 12 years. (redorbit.com)
- In 153 patients who sustained premature cardiovascular disease (CVD) events ≤ age 45, we evaluated the contribution of thrombosis to atherosclerosis-atherothrombosis. (onlinejacc.org)
- As our knowledge on the aging mechanisms in those model systems increases, our understanding of human aging and the potential interventions that we could approach rise significantly. (hindawi.com)
- Our findings confirm the significance of mitochondrial function in the aging process,' said Reversade. (skininc.com)
- Knowledge about the different mechanisms underlying the aging process has increased exponentially in the last decades. (hindawi.com)
- Among the different mechanisms that have been implicated in the aging process, DNA repair is one of the processes which have been suggested to play an important role. (hindawi.com)
- Here, we review the latest investigations supporting the role of these mechanisms in the aging process, stressing how beneficial the use of different model systems is. (hindawi.com)
- This paper explores some of the recent research, which has been performed in order to uncover the relationship between DNA damage, DNA repair mechanisms, and the aging process, and emphasis is given to the use of eukaryotic model systems for this area of research. (hindawi.com)
- Among the wide variety of known DNA lesions, 8-oxo-deoxyguanosine (8oxoG) has received a lot of attention due to its mutagenicity and because of the possible correlation between its accumulation and pathological processes like cancer, degenerative diseases, and aging. (hindawi.com)
- POA is defined as having a low ovarian reserve or poor ovarian reserve relative to what is expected at any given age. (centerforhumanreprod.com)
- Diminished ovarian reserve (DOR) as a result of POA or as a result of advanced female age. (centerforhumanreprod.com)
- A world-renowned reproductive endocrinologist, Dr. Gleicher has published hundreds of peer-reviewed papers and lectured globally while keeping an active clinical career focused on ovarian aging, immunological issues and other difficult cases of infertility. (centerforhumanreprod.com)
- The Center for Human Reproduction's Dr. Vitaly A Kushnir explains that premature ovarian aging (POA) can be a silent form of infertility, as many women with POA have no symptoms. (centerforhumanreprod.com)
- Vitamin C can accelerate the formation of collagen, resist ultraviolet rays, restrain the production of melanin and defer the aging. (lookchem.com)
- Identifying new genes which could affect the aging process. (medindia.net)
- Atherosclerosis is the slow narrowing of the arteries caused by a buildup of fat, cholesterol and other substances and is associated with the natural aging process. (labtestsonline.org)
- Aging is a physiological process that at times is only remotely connected to how old you are. (diagnose-me.com)
- Unfortunately, conventional medical care has focused more on symptom relief with pain medications and surgical procedures and less on reversing the accelerated aging process, which is potentially more effective over the long term. (diagnose-me.com)
- Although the disease process and the aging process may run concurrently, they are not the same thing. (diagnose-me.com)
- Different anatomic and physiological changes occur in the lung of aging people that can affect pulmonary functions, and different pulmonary diseases, including deadly diseases such as chronic obstructive pulmonary disease (COPD)/emphysema and idiopathic pulmonary fibrosis (IPF), can be related to an acceleration of the aging process. (nih.gov)
- Research has found that the aging process speeds up by about five years on average for those with HIV. (prurgent.com)
- However, you might have things in your life that are actually causing your body's aging process to speed up. (thehealthsuccesssite.com)
- The natural aging process would continue to come as long as the earth is turning. (arganoilshop.com)
- In order to understand the aging process, model experiments are of crucial importance. (biomedcentral.com)
- The aging process is a natural occurrence at all. (thealthbenefitsof.com)
- A balanced and healthy diet can reduce cell damage and slow the aging process. (thealthbenefitsof.com)
- Discover How To Hinder The Aging Process On Your Body And In Your Life. (europeanmedical.info)
- But, you might be doing things that are actually causing your body's aging process to accelerate. (beingabeauty.com)
- Not getting adequate amount of sleep speeds up the aging process. (beingabeauty.com)
- Studies have linked melatonin to the aging process, suggesting that melatonin is an anti-aging agent. (directtextbook.com)
- You can't change the natural aging process. (mooresvilledermcenter.com)