National Institute on Aging (U.S.): Component of the NATIONAL INSTITUTES OF HEALTH. Through basic and clinical biomedical research and training, it conducts and supports research into the nature of the aging process and diseases associated with the later stages of life. The Institute was established in 1974.National Institute on Drug Abuse (U.S.): Component of the NATIONAL INSTITUTES OF HEALTH. It supports a comprehensive research portfolio that focuses on the biological, social, behavioral and neuroscientific bases of drug abuse on the body and brain as well as its causes, prevention, and treatment. NIDA, NIAAA, and NIMH were created as coequal institutes within the Alcohol, Drug Abuse and Mental Health Administration in 1974. It was established within the NATIONAL INSTITUTES OF HEALTH in 1992.National Institutes of Health (U.S.): An operating division of the US Department of Health and Human Services. It is concerned with the overall planning, promoting, and administering of programs pertaining to health and medical research. Until 1995, it was an agency of the United States PUBLIC HEALTH SERVICE.National Institute on Alcohol Abuse and Alcoholism (U.S.): Component of the NATIONAL INSTITUTES OF HEALTH. It conducts research focused on improving the treatment and prevention of alcoholism and alcohol-related problems to reduce the health, social, and economic consequences of this disease. NIAAA, NIMH, and NIDA were created as coequal institutes within the Alcohol, Drug Abuse and Mental Health Administration in 1974. It was established within the NATIONAL INSTITUTES OF HEALTH in 1992.Rehabilitation: Restoration of human functions to the maximum degree possible in a person or persons suffering from disease or injury.Community Integration: Policies and programs which ensure that DISPLACED PERSONS and chronic illnesses receive the support and SOCIAL SERVICES needed to live in their communities.Academies and Institutes: Organizations representing specialized fields which are accepted as authoritative; may be non-governmental, university or an independent research organization, e.g., National Academy of Sciences, Brookings Institution, etc.National Institute on Deafness and Other Communication Disorders (U.S.): Component of the NATIONAL INSTITUTES OF HEALTH. It conducts and supports biomedical research and research training on normal mechanisms as well as diseases and disorders of hearing, balance, smell, taste, voice, speech, and language. It was established in 1988.United StatesResearch: Critical and exhaustive investigation or experimentation, having for its aim the discovery of new facts and their correct interpretation, the revision of accepted conclusions, theories, or laws in the light of newly discovered facts, or the practical application of such new or revised conclusions, theories, or laws. (Webster, 3d ed)Physics: The study of those aspects of energy and matter in terms of elementary principles and laws. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Diagnostic Techniques, Neurological: Methods and procedures for the diagnosis of diseases of the nervous system, central and peripheral, or demonstration of neurologic function or dysfunction.Climate Change: Any significant change in measures of climate (such as temperature, precipitation, or wind) lasting for an extended period (decades or longer). It may result from natural factors such as changes in the sun's intensity, natural processes within the climate system such as changes in ocean circulation, or human activities.Gravity Sensing: Process whereby a cell, bodily structure, or organism (animal or plant) receives or detects a gravity stimulus. Gravity sensing plays an important role in the directional growth and development of an organism (GRAVITROPISM).United States National Aeronautics and Space Administration: An independent Federal agency established in 1958. It conducts research for the solution of problems of flight within and outside the Earth's atmosphere and develops, constructs, tests, and operates aeronautical and space vehicles. (From U.S. Government Manual, 1993)Time Factors: Elements of limited time intervals, contributing to particular results or situations.Specific Gravity: The ratio of the density of a material to the density of some standard material, such as water or air, at a specified temperature.Gravity, Altered: A change in, or manipulation of, gravitational force. This may be a natural or artificial effect.Climate: The longterm manifestations of WEATHER. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Gravitation: Acceleration produced by the mutual attraction of two masses, and of magnitude inversely proportional to the square of the distance between the two centers of mass. It is also the force imparted by the earth, moon, or a planet to an object near its surface. (From NASA Thesaurus, 1988)Esophageal Sphincter, Lower: The physiologic or functional barrier to GASTROESOPHAGEAL REFLUX at the esophagogastric junction. Sphincteric muscles remain tonically contracted during the resting state and form the high-pressure zone separating the lumen of the ESOPHAGUS from that of the STOMACH. (Haubrich et al, Bockus Gastroenterology, 5th ed., pp399, 415)Esophageal Sphincter, Upper: The structure at the pharyngoesophageal junction consisting chiefly of the CRICOPHARYNGEUS MUSCLE. It normally occludes the lumen of the ESOPHAGUS, except during SWALLOWING.Manometry: Measurement of the pressure or tension of liquids or gases with a manometer.Esophagogastric Junction: The area covering the terminal portion of ESOPHAGUS and the beginning of STOMACH at the cardiac orifice.Esophagus: The muscular membranous segment between the PHARYNX and the STOMACH in the UPPER GASTROINTESTINAL TRACT.Esophageal Motility Disorders: Disorders affecting the motor function of the UPPER ESOPHAGEAL SPHINCTER; LOWER ESOPHAGEAL SPHINCTER; the ESOPHAGUS body, or a combination of these parts. The failure of the sphincters to maintain a tonic pressure may result in gastric reflux of food and acid into the esophagus (GASTROESOPHAGEAL REFLUX). Other disorders include hypermotility (spastic disorders) and markedly increased amplitude in contraction (nutcracker esophagus).Peristalsis: A movement, caused by sequential muscle contraction, that pushes the contents of the intestines or other tubular organs in one direction.Deglutition: The act of taking solids and liquids into the GASTROINTESTINAL TRACT through the mouth and throat.Pressure: A type of stress exerted uniformly in all directions. Its measure is the force exerted per unit area. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Esophageal Achalasia: A motility disorder of the ESOPHAGUS in which the LOWER ESOPHAGEAL SPHINCTER (near the CARDIA) fails to relax resulting in functional obstruction of the esophagus, and DYSPHAGIA. Achalasia is characterized by a grossly contorted and dilated esophagus (megaesophagus).

The expiry date of man: a synthesis of evolutionary biology and public health. (1/31363)

In industrialised countries, mortality and morbidity are dominated by age related chronic degenerative diseases. The health and health care needs of future populations will be heavily determined by these conditions of old age. Two opposite scenarios of future morbidity exist: morbidity might decrease ("compress"), because life span is limited, and the incidence of disease is postponed. Or morbidity might increase ("expand"), because death is delayed more than disease incidence. Optimality theory in evolutionary biology explains senescence as a by product of an optimised life history. The theory clarifies how senescence is timed by the competing needs for reproduction and survival, and why this leads to a generalised deterioration of many functions at many levels. As death and disease are not independent, future morbidity will depend on duration and severity of the process of senescence, partly determined by health care, palliating the disease severity but increasing the disease duration by postponing death. Even if morbidity might be compressed, health care needs will surely expand.  (+info)

Developmental synaptic changes increase the range of integrative capabilities of an identified excitatory neocortical connection. (2/31363)

Excitatory synaptic transmission between pyramidal cells and fast-spiking (FS) interneurons of layer V of the motor cortex was investigated in acute slices by using paired recordings at 30 degrees C combined with morphological analysis. The presynaptic and postsynaptic properties at these identified central synapses were compared between 3- and 5-week-old rats. At these two postnatal developmental stages, unitary EPSCs were mediated by the activation of AMPA receptors with fast kinetics at a holding potential of -72 mV. The amplitude distribution analysis of the EPSCs indicates that, at both stages, pyramidal-FS connections consisted of multiple functional release sites. The apparent quantal size obtained by decreasing the external calcium ([Ca2+]e) varied from 11 to 29 pA near resting membrane potential. In young rats, pairs of presynaptic action potentials elicited unitary synaptic responses that displayed paired-pulse depression at all tested frequencies. In older animals, inputs from different pyramidal cells onto the same FS interneuron had different paired-pulse response characteristics and, at most of these connections, a switch from depression to facilitation occurred when decreasing the rate of presynaptic stimulation. The balance between facilitation and depression endows pyramidal-FS connections from 5-week-old animals with wide integrative capabilities and confers unique functional properties to each synapse.  (+info)

Low resting potential and postnatal upregulation of NMDA receptors may cause Cajal-Retzius cell death. (3/31363)

Using in situ patch-clamp techniques in rat telencephalic slices, we have followed resting potential (RP) properties and the functional expression of NMDA receptors in neocortical Cajal-Retzius (CR) cells from embryonic day 18 to postnatal day 13, the time around which these cells normally disappear. We find that throughout their lives CR cells have a relatively depolarized RP (approximately -50 mV), which can be made more hyperpolarized (approximately -70 mV) by stimulation of the Na/K pump with intracellular ATP. The NMDA receptors of CR cells are subjected to intense postnatal upregulation, but their similar properties (EC50, Hill number, sensitivity to antagonists, conductance, and kinetics) throughout development suggest that their subunit composition remains relatively homogeneous. The low RP of CR cells is within a range that allows for the relief of NMDA channels from Mg2+ blockade. Our findings are consistent with the hypothesis that CR cells may degenerate and die subsequent to uncontrolled overload of intracellular Ca2+ via NMDA receptor activation by ambient glutamate. In support of this hypothesis we have obtained evidence showing the protection of CR cells via in vivo blockade of NMDA receptors with dizocilpine.  (+info)

Somatic recording of GABAergic autoreceptor current in cerebellar stellate and basket cells. (4/31363)

Patch-clamp recordings were performed from stellate and basket cells in rat cerebellar slices. Under somatic voltage clamp, short depolarizing pulses were applied to elicit action potentials in the axon. After the action potential, a bicuculline- and Cd2+-sensitive current transient was observed. A similar response was obtained when eliciting axonal firing by extracellular stimulation. With an isotonic internal Cl- solution, the peak amplitude of this current varied linearly with the holding potential, yielding an extrapolated reversal potential of -20 to 0 mV. Unlike synaptic or autaptic GABAergic currents obtained in the same preparation, the current transient had a slow rise-time and a low variability between trials. This current was blocked when 10 mM BAPTA was included in the recording solution. In some experiments, the current transient elicited axonal action potentials. The current transient was reliably observed in animals aged 12-15 d, with a mean amplitude of 82 pA at -70 mV, but was small and rare in the age group 29-49 d. Numerical simulations could account for all properties of the current transient by assuming that an action potential activates a distributed GABAergic conductance in the axon. The actual conductance is probably restricted to release sites, with an estimated mean presynaptic current response of 10 pA per site (-70 mV, age 12-15 d). We conclude that in developing rats, stellate and basket cell axons have a high density of GABAergic autoreceptors and that a sizable fraction of the corresponding current can be measured from the soma.  (+info)

Fas/Apo [apoptosis]-1 and associated proteins in the differentiating cerebral cortex: induction of caspase-dependent cell death and activation of NF-kappaB. (5/31363)

The developing cerebral cortex undergoes a period of substantial cell death. The present studies examine the role of the suicide receptor Fas/Apo[apoptosis]-1 in cerebral cortical development. Fas mRNA and protein are transiently expressed in subsets of cells within the developing rat cerebral cortex during the peak period of apoptosis. Fas-immunoreactive cells were localized in close proximity to Fas ligand (FasL)-expressing cells. The Fas-associated signaling protein receptor interacting protein (RIP) was expressed by some Fas-expressing cells, whereas Fas-associated death domain (FADD) was undetectable in the early postnatal cerebral cortex. FLICE-inhibitory protein (FLIP), an inhibitor of Fas activation, was also expressed in the postnatal cerebral cortex. Fas expression was more ubiquitous in embryonic cortical neuroblasts in dissociated culture compared to in situ within the developing brain, suggesting that the environmental milieu partly suppresses Fas expression at this developmental stage. Furthermore, FADD, RIP, and FLIP were also expressed by subsets of dissociated cortical neuroblasts in culture. Fas activation by ligand (FasL) or anti-Fas antibody induced caspase-dependent cell death in primary embryonic cortical neuroblast cultures. The activation of Fas was also accompanied by a rapid downregulation of Fas receptor expression, non-cell cycle-related incorporation of nucleic acids and nuclear translocation of the RelA/p65 subunit of the transcription factor NF-kappaB. Together, these data suggest that adult cortical cell number may be established, in part, by an active process of receptor-mediated cell suicide, initiated in situ by killer (FasL-expressing) cells and that Fas may have functions in addition to suicide in the developing brain.  (+info)

Metrifonate increases neuronal excitability in CA1 pyramidal neurons from both young and aging rabbit hippocampus. (6/31363)

The effects of metrifonate, a second generation cholinesterase inhibitor, were examined on CA1 pyramidal neurons from hippocampal slices of young and aging rabbits using current-clamp, intracellular recording techniques. Bath perfusion of metrifonate (10-200 microM) dose-dependently decreased both postburst afterhyperpolarization (AHP) and spike frequency adaptation (accommodation) in neurons from young and aging rabbits (AHP: p < 0.002, young; p < 0.050, aging; accommodation: p < 0.024, young; p < 0.001, aging). These reductions were mediated by muscarinic cholinergic transmission, because they were blocked by addition of atropine (1 microM) to the perfusate. The effects of chronic metrifonate treatment (12 mg/kg for 3 weeks) on CA1 neurons of aging rabbits were also examined ex vivo. Neurons from aging rabbits chronically treated with metrifonate had significantly reduced spike frequency accommodation, compared with vehicle-treated rabbits. Chronic metrifonate treatment did not result in a desensitization to metrifonate ex vivo, because bath perfusion of metrifonate (50 microM) significantly decreased the AHP and accommodation in neurons from both chronically metrifonate- and vehicle-treated aging rabbits. We propose that the facilitating effect of chronic metrifonate treatment on acquisition of hippocampus-dependent tasks such as trace eyeblink conditioning by aging subjects may be caused by this increased excitability of CA1 pyramidal neurons.  (+info)

Thiamine deficiency is prevalent in a selected group of urban Indonesian elderly people. (7/31363)

This cross-sectional study involved 204 elderly individuals (93 males and 111 females). Subjects were randomly recruited using a list on which all 60-75 y-old-people living in seven sub-villages in Jakarta were included. The usual food intake was estimated using semiquantitative food frequency questionnaires. Hemoglobin, plasma retinol, vitamin B-12, red blood cell folate and the percentage stimulation of erythrocyte transketolase (ETK), as an indicator of thiamine status, were analyzed. Median energy intake was below the assessed requirement. More than 75% of the subjects had iron and thiamine intakes of approximately 2/3 of the recommended daily intake, and 20.2% of the study population had folate intake of approximately 2/3 of the recommended daily intake. Intakes of vitamins A and B-12 were adequate. Biochemical assessments demonstrated that 36.6% of the subjects had low thiamine levels (ETK stimulation > 25%). The elderly men tended to have lower thiamine levels than the elderly women. The overall prevalence of anemia was 28.9%, and the elderly women were affected more than the elderly men. Low biochemical status of vitamins A, B-12 and RBC folate was found in 5.4%, 8.8 % and 2.9% of the subjects, respectively. Dietary intakes of thiamine and folate were associated with ETK stimulation and plasma vitamin B-12 concentration (r = 0.176, P = 0.012 and r = 0.77, P = 0.001), respectively. Results of this study suggest that anemia, thiamine and possibly vitamin B-12 deficiency are prevalent in the elderly living in Indonesia. Clearly, micronutrient supplementation may be beneficial for the Indonesian elderly population living in underprivileged areas.  (+info)

High-linoleate and high-alpha-linolenate diets affect learning ability and natural behavior in SAMR1 mice. (8/31363)

Semipurified diets incorporating either perilla oil [high in alpha-linolenate, 18:3(n-3)] or safflower oil [high in linoleate, 18:2(n-6)] were fed to senescence-resistant SAMR1 mouse dams and their pups. Male offspring at 15 mo were examined using behavioral tests. In the open field test, locomotor activity during a 5-min period was significantly higher in the safflower oil group than in the perilla oil group. Observations of the circadian rhythm (48 h) of spontaneous motor activity indicated that the safflower oil group was more active than the perilla oil group during the first and second dark periods. The total number of responses to positive and negative stimuli was higher in the safflower oil group than in the perilla oil group in the light and dark discrimination learning test, but the correct response ratio was lower in the safflower oil group. The difference in the (n-6)/(n-3) ratios of the diets reflected the proportions of (n-6) polyunsaturated fatty acids, rather than those of (n-3) polyunsaturated fatty acids in the brain total fatty acids, and in the proportions of (n-6) and (n-3) polyunsaturated fatty acids in the total polyunsaturated fatty acids of the brain phospholipids. These results suggest that in SAMR1 mice, the dietary alpha-linolenate/linoleate balance affects the (n-6)/(n-3) ratio of brain phospholipids, and this may modify emotional reactivity and learning ability.  (+info)

*2008 in science

The condition is more common in young and middle-aged women. (Phys.org) New research reveals that Pleistocene cave bears, a ...

*Future sea level

... the rate of sea-level rise is roughly proportional to the magnitude of warming above the temperatures of the pre-Industrial Age ...

*Human-centered computing

... and successful aging. Models for effective computer-mediated human-human interaction under a variety of constraints, (e.g., ...

*Title 51 of the United States Code

... before the Space Age. Title 51 does not modify or repeal existing programs. Rather, it restates existing law in a manner that ...

*Aging (journal)

According to Scopus/Scimago Journal Rank (2015), Aging is ranked number 3 on Cites/Docs (2 years) in the Aging category. Aging ... "Journal rankings on Aging". SJR. Retrieved 2017-06-22. "Aging". NLM Catalog. National Center for Biotechnology Information. ... Aging is a peer-reviewed open access scientific journal. The journal and publisher were listed on Jeffrey Beall's lists of " ... "Mikhail Blagosklonny's Journal Aging: A Review". Scholarly Open Access. 6 December 2016. Archived from the original on 24 ...

*Aging Cell

... is a peer-reviewed scientific journal and an official journal of the Anatomical Society. It is published on their ... "Aging Cell". 2012 Journal Citation Reports. Web of Science (Science ed.). Thomson Reuters. 2013. Official website. ... stem cells and aging, signaling and gene expression, cell stress and damage, integrative physiology, etc. The journal publishes ... Buck Institute for Research on Aging), and John Sedivy (Brown University). The journal covers research on genes and functional ...

*Software aging

Designing software that can be immune to aging is difficult. Not all software will age at the same rate as some users use the ... M. Grottke, R. Matias Jr., and K. S. Trivedi, "The Fundamentals of Software Aging," Workshop of Software Aging and Rejuvenation ... We can't prevent aging, but we can understand its causes, take steps to limit its effects, temporarily reverse some of the ... In widely used and specialized software, a common action to clear a problem is rebooting because aging occurs due to the ...

*Drugs & Aging

... is a monthly peer-reviewed medical journal published by Springer Science + Business Media under their Adis ... "Drugs & Aging". 2014 Journal Citation Reports. Web of Science (Science ed.). Thomson Reuters. 2015. Official website. ...

*Accelerated aging

... which means the accelerated aging process and natural aging process are not parallel. Another is that paper is a "complex ... began a long-term experiment in 2000 to compare artificially aged materials to materials allowed to undergo natural aging for a ... Accelerated aging is also used in library and archival preservation science. In this context, a material, usually paper, is ... Accelerated aging was further refined during the 1920s, with tests using sunlight and elevated temperatures being used to rank ...

*Ending Aging

... : The Rejuvenation Breakthroughs that Could Reverse Human Aging in Our Lifetime is a 2007 book written by Aubrey de ... Ending Aging describes de Grey's proposal for eliminating aging as a cause of debilitation and death in humans, and restoring ... Best, Ben (December 2007). "Book Review - Ending Aging: The Rejuvenation Breakthroughs That Could Reverse Human Aging in Our ... Ettinger, Robert (Nov-Dec 2007). "New De Grey Book - Ending Aging by Aubrey de Grey with Michael Rae, St. Martin's Press 2007 ...

*Aging offender

An aging offender or an elderly offender in an individual over the age of 55 who breaks the law or is in prison. The numbers of ... Incarceration tends to accelerate the aging process" Surveys conducted of criminals over the age of 55 being imprisoned for the ... gambling and drunkenness either being unlimited by age or peaking when a criminal is of the age of 50 or above. Newman, Newman ... and the need to recognise differences between normal aging and aging accelerated by being in prison. Health care is identified ...

*Productive aging

"CDC - Productive Aging and Work - What is Productive Aging? - NIOSH Workplace Safety and Health Topic". www.cdc.gov. Retrieved ... Productive aging refers to activities which older people engage in on a daily basis. Older adults have opportunities and ... One example of productive aging is retirement which moves older adults from paid forms of productivity to nonpaid activities. ... Many activities can give older adults opportunities and constraints related to the productive aging process. These activities ...

*Aging brain

Aging Aging movement control Alzheimer's disease Dementia DNA damage theory of aging Life extension List of life extension ... "The cerebellum ages slowly according to the epigenetic clock" (PDF). Age (Albany US). 7 (5): 294-306. doi:10.18632/aging.100742 ... Cognition in aging and age related disease. In P. R. Hof & C. V. Mobbs (Eds.), Handbook of the neuroscience of aging (249-256 ... CT scans have found that the cerebral ventricles expand as a function of age. More recent MRI studies have reported age-related ...

*Rejuvenation (aging)

Ageless Aging brain American Academy of Anti-Aging Medicine Biogerontology Biological immortality DNA repair DNA damage theory ... Life extension strategies often study the causes of aging and try to oppose those causes in order to slow aging. Rejuvenation ... de Grey, Aubrey; Rae, Michael (September 2007). Ending Aging: The Rejuvenation Breakthroughs that Could Reverse Human Aging in ... was applied as a robust method of decelerating aging and the development of age-related diseases. The biomedical gerontologist ...

*Beef aging

"Effects of dry aging of bone-in and boneless strip loins using two aging processes for two aging times". Meat Science. 83 (4): ... "Spotlight on dry aging beef: Effects of loin type, aging methods, and aging time". Kansas State University. Agricultural ... Wet-aged beef is beef that has typically been aged in a vacuum-sealed bag to retain its moisture. This is the dominant mode of ... because it takes time and there is a significant loss of weight during the aging process. Dry-aging can take from 15 to 28 days ...

*Aging (scheduling)

Aging is used to gradually increase the priority of a task, based on its waiting time in the ready queue. In priority-based ... Aging is used to ensure that jobs with lower priority will eventually complete their execution. This technique can be used to ... In Operating systems, aging (US English) or ageing is a scheduling technique used to avoid starvation. Fixed priority ... There are many ways to implement aging, but all have the same principle that the priority of a process should increase as it ...

*Aging out

... is also used in reference to Drum Corps International's rules which state that drum corps' members above the age of ... Aging Out - 2004 PBS Documentary IMDB Page for Aging Out Documentary [1] "The Original Foster Care Survival Guide" website. ... nd) [How Do I Prevent My Child From Losing Benefits at Age 21 ("Aging Out")?] United States Citizenship and Immigration ... "Aging Out or Aging In?" Archived September 29, 2007, at the Wayback Machine. Youth Today. January 1996. Retrieved 5/8/07. (2006 ...

*Aging (food)

Aging can be done under a number of conditions, and for a number of reasons: Drying of foods by leaving them in a low-humidity ... Aging (American English) or ageing (British English), in the context of food or beverages, is the leaving of a product over an ... Foods may be aged to allow fermentation to occur, such as in the making of alcoholic beverages, in cheesemaking, in pickling, ... This is especially true in processes such as the making of blue cheese or aged beef. In the case of beverages, such as the ...

*Aging (artwork)

Ageing is a process by which an artwork, typically a painting or sculpture, is made to appear old. It is meant to emulate the natural deterioration that can occur over many decades or centuries. Paintings deteriorate over time because they are created using essentially incompatible materials, with each having a different reaction to the changes in the environment, including light, temperature and relative humidity. An oil painting consists of several layers, comprising the base canvas, a layer of gesso base coat, several layers of the oil-based paint and then several coats of varnish to protect the paint surface. With many different materials, it is understandable that each layer may dry at different rates and will also absorb and release moisture at different rates. When this occurs, expansion and contraction of the painting will result in a crazing of the varnish surface. This pattern of small cracks is known as craquelure. Along with the darkening or yellowing of the varnish surface, it is ...

*Genetics of aging

... and he named the gene age-1 in the expectation that other genes that control aging would be found. The age-1 gene encodes the ... Genetics of aging is generally concerned with life extension associated with genetic alterations, rather than with accelerated ... The first mutation found to increase longevity in an animal was the age-1 gene in Caenorhabditis elegans. Michael Klass ... According to the GenAge database of aging-related genes, there are over 1800 genes altering lifespan in model organisms: 838 in ...

*Psychology and Aging

... is a monthly peer-reviewed scientific journal published by the American Psychological Association. The ... "Psychology and Aging". American Psychological Association. July 25, 2012. Retrieved 2012-07-25. "Journals Ranked by Impact: ... current editor-in-chief is Ulrich Mayr (University of Oregon). It covers research on adult development and aging whether ...

*The Aging Male

... is a quarterly peer-reviewed medical journal that covers all aspects of male health throughout the aging process ... "The Aging Male Editorial Board". Retrieved 14 June 2010. "The Aging Male". 2014 Journal Citation Reports. Web of Science ( ... It is the official journal of the International Society for the Study of the Aging Male and is published by Taylor and Francis ...

*Experimental Aging Research

... is a peer-reviewed scientific journal covering research on life span and aging from a psychological ... "Experimental Aging Research". 2011 Journal Citation Reports. Web of Science (Science ed.). Thomson Reuters. 2012. ,access-date ...

*American Aging Association

Harman served as the first president of AGE, and was executive director of AGE for 20 years (1973 to 1993). AGE has received ... AGE was founded in 1970 by Denham Harman, MD, PhD, who is often known as the "father" of the "free-radical theory of aging". Dr ... 41st annual conference of AGE was held on June 1 - June 4, 2012 in Fort Worth, Texas. 42nd annual conference of AGE was held on ... The vice-presidency of AGE is to be a layperson position focused on promoting the scientific goals of AGE to the general public ...

*Aging in cats

When a cat's age is given in cat years that is an approximately equivalent age in humans. For example, a cat that is 5 1/2 ... some cats may attain the age of 21 years or more. The oldest cat ever recorded was Creme Puff, who died in 2005, aged 38 years ... Aging O'Neill, Dan G; Church, David B; McGreevy, Paul D; Thomson, Peter C; Brodbelt, David C (2015-02-01). "Longevity and ... old would be said to be 38 cat years old if the stage of life of the cat is comparable to that of human of 38 years of age. ...
Musculoskeletal conditions are a major burden on individuals, healthcare systems, and social care systems throughout the world, with indirect costs having the predominant economic impact. Aging is a major contributing factor to the development and progression of arthritic and musculoskeletal diseases. Indeed, aging and inflammation (often referred to as "inflammaging") are critical risk factors for the development of osteoarthritis (OA), which is one the most common forms of joint disease. The term "chondrosenescence" has recently been introduced to define the age-dependent deterioration of chondrocyte function and how it undermines cartilage function in OA. An important component of chondrosenescence is the age-related deregulation of subcellular signalling pathways in chondrocytes. This mini-review discusses the role of age-related alterations in chondrocyte signaling pathways. In this article we focus our attention on two major areas: age-dependent alterations in transforming growth factor-β ...
Investigations of intracellular signaling revealed reduced phosphorylation of AKT in MDDCs from aging, suggesting decreased activation of PI3kinase signaling pathway. Since PI3K signaling pathway plays a positive regulatory role in phagocytosis and migration, and it also functions as a negative regulator of TLR signaling by inducing activation of p38 MAP kinase, this may explain the aberrant innate immune functioning of DCs from aged subjects. Results further revealed an increased expression of PTEN, a negative regulator of PI3Kinase signaling pathway, in MDDCs from aged subjects. Increased PTEN may thus be responsible for the defect in AKT phosphorylation and therefore, altered innate immune response of DCs from aged humans.. This study is supported in part by a grant AG027512 from NIH and partly by new scholar grant from the Ellison Medical Foundation. ...
Voltage-gated sodium channels (VGSCs) generate the Na+ current (INa) responsible for the cardiac action potential upstroke largely due to the cardiac isoform Nav1.5, but other isoforms are responsible for ˜20% of the upstroke and a component of a sustained sodium current. This sustained component has been attributed with an increasing arrhythmia risk, particularly within the elderly and has been the target of development for new anti-arrhythmic drugs. Our study has investigated the age-associated changes in protein density and localisation of the VGSC alpha-subunits Nav1.5 and Nav1.4 in the rat heart.. Rats at 6, 12 and 28 months of age were sacrificed, their hearts dissected into the regions of left and right ventricle, left and right atria, epicardium and endocardium (n = 5). These regions were analysed by western blot to determine the protein expression of Nav1.5 and Nav1.4 (Alomone, Israel), normalised to the expression of desmin (Dako, UK). Immunocytochemistry of single cardiac myocytes ...
Researchers at Mayo Clinic have shown that eliminating cells that accumulate with age could prevent or delay the onset of age-related disorders and disabilities. The study, performed in mouse models, provides the first evidence ...
Greater social contact and support are associated with better cognitive functioning, whereas greater conflict is associated with lower cognitive functioning.. Diseases either caused by or associated with aging - particularly vascular changes - play a larger role in age-related cognitive changes than is often acknowledged.. This collection of articles, titled "Cognition, Health, and Aging: Integrating Perspectives Across Disciplines," is based on papers presented at a conference held at Penn State University in 2009. Funding for the supplemental issue was provided by the National Institute on Aging through the resources of the Center on Population Health and Aging at Penn State University, and the National Academies Keck Futures Initiative grant, Health and Healthspan in Longitudinal Studies of Aging.. The Journals of Gerontology Series B: Psychological Sciences and Social Sciences is a refereed publication of The Gerontological Society of America (GSA), the nations oldest and largest ...
The retinal hypoperfusion found in the present study is also in support of the cerebral hypoperfusion, which occurs during normal aging (Table 4).1,5,11,22 Chen et al.1 studied the age-related reduction of CBF during normal aging in a cohort of normal subjects and found that the CBF as an indirect measurement of brain perfusion declined at a rate of −0.38% per year when the entire cortex was examined. Meanwhile, the cortical grey matter volume decreased at a rate of −0.85% per year, which exceeds the reductions in CBF.1 Leenders et al.5 reported that the CBF, cerebral blood volume, and cerebral metabolic rates of oxygen decline at a rate of −0.5% per year during normal aging. The changing rate of the RTP (−0.47% per year), RBF (−0.41% per year), and VVDd (−0.44% per year) found in the present study well matches the CBF change rates reported by Chen et al.1 and Leenders et al.,5 indicating that the RTP, RBF, and VVDd may be good candidates for imaging markers of the age-related ...
Huber, N., Sakai, N., Eismann, T., Shin, T., Kuboki, S., Blanchard, J., Schuster, R., Edwards, M. J., Wong, H. R. and Lentsch, A. B. (2009), Age-related decrease in proteasome expression contributes to defective nuclear factor-κB activation during hepatic ischemia/reperfusion. Hepatology, 49: 1718-1728. doi: 10.1002/hep.22840 ...
Age-related alterations in brain structure and function have been challenging to link to cognition due to potential overlapping influences of multiple neurobiological cascades. We examined multiple brain markers associated with age-related variation in cognition. Clinically normal older humans aged 65-90 from the Harvard Aging Brain Study (N = 186) were characterized on a priori magnetic resonance imaging markers of gray matter thickness and volume, white matter hyperintensities, fractional anisotropy (FA), resting-state functional connectivity, positron emission tomography markers of glucose metabolism and amyloid burden, and cognitive factors of processing speed, executive function, and episodic memory. Partial correlation and mediation analyses estimated age-related variance in cognition shared with individual brain markers and unique to each marker. The largest relationships linked FA and striatum volume to processing speed and executive function, and hippocampal volume to episodic memory. ...
In the past two decades neuroimaging studies have tried to unveil the neural mechanisms behind age-related changes in cognitive strategies and performance. Structural imaging studies have shown that brain volume changes throughout the complete life-span and functional imaging studies have reported age-related differences in brain activation and connectivity. ... read more The aim of this thesis was to provide an overview of studies that report age-related changes in brain activation as measured with functional MRI in a longitudinal design in healthy subjects. We found 16 studies of which 11 reported changes in activity over time. The majority of studies was performed in children. fMRI task used varied between attention, language, memory, working memory and sensory processing tasks. We found increases and decreases in activation in children between 5 and 20 and adults above age 50. A trend of left-hemispheric increases were shown for children around age 8, adults around age 66 and in language ...
Age is the single greatest risk factor in the development of the blinding eye disease AMD where the prevalence of disease significantly increases as individuals enter their sixth decade. 2,3 In spite of this universal observation, other factors that lead to increased disease incidence remain undefined. Increases in damage from environmental stresses, accumulation of damaged proteins and organelles, and loss of function in important biochemical pathways all have been proposed. 3,4,13,52 The immune system is also thought to have a role in disease development 12-14,53 ; however, few studies have addressed how age-related changes in the immune response could be involved. The eye also is an immune privileged organ that can have a strong inhibitory influence on inflammatory and neovascular responses via a number of immunosuppressive mediators. 21 How age-dependent changes in the immune system are influenced by immune privilege and how age might alter the function of immune privilege is currently ...
Immune aging may underlie various aging-related disorders, including diminished resistance to infection, chronic inflammatory disorders, and autoimmunity. PD-1+ and CD153+ CD44high CD4+ T cells with features of cellular senescence, termed senescence-associated T (SA-T) cells, increasingly accumulate with age and may play a role in the immune aging phenotype. In this article, we demonstrate that, compared with young mice, the aged mouse environment is highly permissive for spontaneous proliferation of transferred naive CD4+ T cells, and it drives their transition to PD-1+ and CD153+ CD44high CD4+ T cells after extensive cell divisions. CD4+ T cells with essentially the same features as SA-T cells in aged mice are also generated from naive CD4+ T cells after extensive cell divisions under severe T-lymphopenic conditions by gamma irradiation or in developmental T cell defect, often in association with spontaneous germinal centers, as seen in aged mice. The increase in SA-T cells is significantly enhanced
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The present study tested whether aging alters endotoxin-induced myocardial dysfunction in a sublethal model of endotoxemia in rats. The main findings were the following: 12 hours after LPS injection (0.5 mg/kg), a marked reduction in myocardial contractility was observed in the isolated perfused senescent heart; in contrast with septic cardiac dysfunction in young rats, myofilament Ca2+ sensitivity of left ventricular skinned fibers was not reduced in senescent rats; and NO production, oxidative stress, and antioxidant enzymes activities were not different between young adult and senescent LPS groups. Thus, despite similar alterations in potential mediators, cellular mechanisms responsible for this contractile dysfunction are different between young adult and senescent rats. More specifically, myofilament Ca2+ responsiveness remains unaltered in the senescent heart. This may have clinical implications for management of elderly septic patients.. Nonlethal models of endotoxemia have allowed ...
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Various age-related changes in the biomechanics and topography of different ocular components have been reported in the literature. Albon et al. (2000) observed a decrease in both the mechanical compliance and resilience of the human lamina cribrosa with age, and similar observations were made by Krag et al. (1997) in the lens capsule. Strong association was found between the age-related alterations in the optic nerve head and its increased susceptibility to glaucomatous damage (Burgoyne & Downs 2008). The asphericity of both the anterior and posterior corneal surfaces was reported to undergo significant changes with age, leading to a more spherical topography (Lam & Douthwaite 2002) and peripheral thinning (Dubbelman et al. 2006). Stiffening and increased tensile strength of the sclera were also found to be strongly associated with age (Avetisov et al. 1983; Schultz et al. 2008). Where an explanation was provided for these changes, it was the age-related increase in the intermolecular and ...
Evidence for age-dependent impairment of ovalbumin heterogeneous nuclear RNA (HnRNA) processing in hen oviduct.: The expression of the ovalbumin gene in hen ovi
This data collection contains data gathered in a longitudinal study of a sample of men aged 65 to 92 who were in good health during the first wave of the study in 1957. The chief aim of the study was to focus on the nature of the normal aging process in individuals of advanced age. The 47 study participants had not suffered from accidents, illnesses, severe emotional or personality problems, or environmental difficulties that might have led to premature aging, but 20 participants showed evidence of asymptomatic subclinical disease. This group represented the typical or average healthy aged individual with minimal degrees of physical pathology. Five years later, in 1962, a follow-up study was conducted with 29 of the 39 men still alive. The second follow-up, done in 1968, involved 19 of the surviving 23 men. The data are arranged in files by year: 1957, 1962, and 1968. Included are psychiatric data and medical evaluative data as well as various psychological and medical test scores (e.g., ...
This data collection contains data gathered in a longitudinal study of a sample of men aged 65 to 92 who were in good health during the first wave of the study in 1957. The chief aim of the study was to focus on the nature of the normal aging process in individuals of advanced age. The 47 study participants had not suffered from accidents, illnesses, severe emotional or personality problems, or environmental difficulties that might have led to premature aging, but 20 participants showed evidence of asymptomatic subclinical disease. This group represented the typical or average healthy aged individual with minimal degrees of physical pathology. Five years later, in 1962, a follow-up study was conducted with 29 of the 39 men still alive. The second follow-up, done in 1968, involved 19 of the surviving 23 men. The data are arranged in files by year: 1957, 1962, and 1968. Included are psychiatric data and medical evaluative data as well as various psychological and medical test scores (e.g., ...
The effects of the co-agonist of the N-methyl-d-aspartate receptor (NMDAr) d-serine on glutamatergic neurotransmission and synaptic potentiation were studied in the CA1 hippocampal field of young (3-5 months old) and aged (25-27 months old) Sprague-Dawley rats using ex vivo extracellular electrophysiological recording techniques. Exogenous d-serine depressed fast neurotransmission mediated by the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid/kainate subtype of glutamate receptors in young but not in aged rats by acting on inhibitory glycinergic interneurons. In contrast, d-serine dose-dependently enhanced NMDAr-mediated synaptic responses in both groups of animals, but with a larger magnitude in aged rats, thus preventing the age-related decrease in NMDAr activation. d-serine also increased the magnitude of long-term potentiation in aged but not in young rats. Finally, d-serine levels were dramatically reduced in hippocampal tissues of aged rats. Taken together, these results indicate a ...
Background: Acute lung injury (ALI) is a significant source of morbidity and mortality in critically ill patients. Age is a major determinant of clinical outcome in ALI. The increased ALI-associated mortality in the older population suggests that there are age-dependent alterations in the responses to pulmonary challenge. The objective of this observational study was to evaluate age-dependent differences in the acute (within 6 hours) immunological and physiological responses of the heart and lung, to pulmonary challenge, that could result in increased severity. Methods: Male C57Bl/6 mice (young: 2-3 months, old: 18-20 months) were challenged intratracheally with cell wall components from Gram-positive bacteria (lipoteichoic acid and peptidoglycan). After 6 hours, both biochemical and physiological consequences of the challenge were assessed. Alveolar infiltration of inflammatory cells and protein, airspace and blood cytokines, cardiac function and myocardial proteasome activity were determined. Results:
Aging-related changes in the brain have been mostly studied through the comparison of young adult and very old animals. However, aging must be considered a lifelong process of cumulative changes that ultimately become evident at old age. To determine when this process of decline begins, we studied how the cellular composition of the rat brain changes from infancy to adolescence, early adulthood, and old age. Using the isotropic fractionator to determine total numbers of neuronal and non-neuronal cells in different brain areas, we find that a major increase in number of neurons occurs during adolescence, between 1 and 2-3 months of age, followed by a significant trend of widespread and progressive neuronal loss that begins as early as 3 months of age, when neuronal numbers are maximal in all structures, until decreases in numbers of neurons become evident at 12 or 22 months of age. Our findings indicate that age-related decline in the brain begins as soon as the end of adolescence, a novel finding has
Chair: Juulia Jylhävä. Markers of biological age have recently proven to be strong mortality predictors independent of other risk factors. As individuals with the same chronological age can vary substantially for their biological age it has become a pressing issue to find the determinants for biological age. This symposium presents findings on the genetic and environmental influences to the following markers of biological age: self-rated health, the frailty index, the epigenetic clock and telomere length. Using unique longitudinal twin cohorts with wide age ranges, we are also able to assess the changes in the contributing sources variation - i.e., genetics and shared and unique environments. The first paper demonstrates how the heritability of self-rated health is influenced by financial strain. The second paper examines if the polygenic risk scores for well-being are predictive of objective (i.e. frailty and multi-morbidity) and subjective indicators of age-related health (e.g. ...
Recent statistics indicate that the human population is ageing rapidly. Healthy, but also diseased, elderly people are increasing. This trend is particularly evident in Western countries, where healthier living conditions and better cures are available. To understand the process leading to age-associated alterations is, therefore, of the highest relevance for the development of new treatments for age-associated diseases, such as cancer, diabetes, Alzheimer and cardiovascular accidents. Mechanistically, it is well accepted that the accumulation of intracellular damage determined by reactive oxygen species (ROS) might orchestrate the progressive loss of control over biological homeostasis and the functional impairment typical of aged tissues. Here, we review how epigenetics takes part in the control of stress stimuli and the mechanisms of ageing physiology and physiopathology. Alteration of epigenetic enzyme activity, histone modifications and DNA-methylation is, in fact, typically associated with the
Recent statistics indicate that the human population is ageing rapidly. Healthy, but also diseased, elderly people are increasing. This trend is particularly evident in Western countries, where healthier living conditions and better cures are available. To understand the process leading to age-associated alterations is, therefore, of the highest relevance for the development of new treatments for age-associated diseases, such as cancer, diabetes, Alzheimer and cardiovascular accidents. Mechanistically, it is well accepted that the accumulation of intracellular damage determined by reactive oxygen species (ROS) might orchestrate the progressive loss of control over biological homeostasis and the functional impairment typical of aged tissues. Here, we review how epigenetics takes part in the control of stress stimuli and the mechanisms of ageing physiology and physiopathology. Alteration of epigenetic enzyme activity, histone modifications and DNA-methylation is, in fact, typically associated with the
Aged rats (22 to 24 months) and young control rats (3 months) were tested in a battery of behavioral tests which included tests of learning, place navigation, sensorimotor integration, motor coordination, activity, and exploration. Following testing all animals were analyzed in an unanesthetized state for their local glucose utilization. Significant differences in glucose utilization were found between the aged and young groups on some behaviors and in some brain regions. There was considerable variability in the aged group in both their behavioral performance and their glucose utilization scores; thus, attempts were made to determine whether the variability in the degree of impairment within any particular behavioral test was correlated to the regional glucose utilization scores in any of the 45 brain regions analyzed. In two of the behavioral tests employed (i.e., one for learning and one for place navigation), the decline in performance correlated significantly with the decrement in regional ...
Cellular ageing can lead to altered cell mechanical properties and is known to affect many fundamental physiological cell functions. To reveal age-dependent changes in cell mechanical properties and in active mechanoresponses, the stiffness of human
Matsuzawa, T and Cinader, B, "Polymorphism of age-dependent changes in the production of a thf helper factor." (1982). Subject Strain Bibliography 1982. 2609 ...
Age-dependent changes in the exocytotic efficacy in Kir6.2 ablated mouse pancreatic β-cells. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
Reduced volume, or atrophy, in parts of the brain known as the amygdala and hippocampus may predict which cognitively healthy elderly people will develop dementia over a six-year period, according to a study.
The results of the present experiments establish that angiogenesis is impaired as a function of age. The reduced capability for collateral vessel development in response to ischemia was confirmed in 2 different animal models. The ultimate hindlimb BPR achieved at 40 days after surgery was significantly less in old than in young NZW rabbits. In old mice, perfusion of the ischemic hindlimb, reflected by the Doppler flow ratio, was significantly reduced compared with young mice; this difference was apparent as soon as 7 days after surgery and persisted throughout the duration (28 days) of the study. Likewise, the number of blood vessels that were angiographically visible in rabbits and the number of capillaries per unit area identified histologically in mice and rabbits were both significantly reduced in old versus young animals. The latter finding is consistent with the observation that myocardial angiogenesis related to left ventricular hypertrophy is attenuated in an age-dependent manner.20 The ...
Our results demonstrate that overexpression of mCAT protects mice from cardiac aging, providing direct evidence for the role of mitochondrial ROS in the aging of this vital organ. Several lines of evidence support this conclusion. In WT mice from the longevity cohort, we found age-dependent LV hypertrophy and a decline in cardiac performance (especially diastolic function), concomitant with the accumulation of oxidized mitochondrial proteins, mtDNA mutations, increased ventricular fibrosis, cardiomyocyte hypertrophy, a decline in SERCA2 protein, and activation of the calcineurin-NFAT pathway in the aged heart. These age-related alterations took place in the absence of significant cardiovascular risks such as diabetes, hypertension, or hypercholesterolemia, suggesting that these findings are primary changes of cardiac aging rather than secondary to other diseases. mCAT littermates were partially protected from all of the above age-related cardiac alterations, suggesting that these aging changes ...
Two groups of investigators in Canada, from the University of British Columbia, Vancouver and the University of Victoria, recently published the results of their study on the age-associated decline in memory in the journal PLoS ONE. The article, "Glutathione Restores the Mechanism of Synaptic Plasticity in Aged Mice to That of the Adult," details the teams research and conclusions on the connection between maintaining memory and a healthy redox balance in brain cells.. Previous research associated a reduced redox potential (a more oxidized cellular environment) with aging and demonstrated a correlation, in the hippocampus (specifically the CA1 region), to a lower level of the major antioxidant, glutathione (GSH). The British Columbian investigators hypothesized not only that age-associated memory impairment is a consequence of this condition, but also that GSH is key to one of two related hippocampal mechanisms.. The two mechanisms are involved in calcium ion transport and necessary for memory ...
University of Arizona Aging is associated with specific impairments of learning and memory, some of which are similar to those caused by damage to temporal or frontal lobe structures. For example, healthy older humans, monkeys and rats all show poorer spatial, recognition and working memory, than do their younger counterparts. Rats and monkeys do not develop age-related pathology such as Alzheimers or Parkinsons diseases, which makes them good models for assessing functional alterations associated with normal aging in humans. While many cellular properties of medial temporal lobe cells appear to be intact in aging animals, age-related impairments in synaptic function, plasticity and gene expression have been observed. Because information is represented by activity patterns across large populations of neurons, an understanding of the neural basis of cognitive changes in aging requires the examination of the dynamics of behaviorally-driven neural networks. Ensemble recording experiments are ...
Protect your brain and prevent age-related brain shrinkage, memory loss and dementia with a micronutrient-rich diet and supplemental DHA
The relationship between mental exercise and mental aging is a controversial issue. People generally believe the so-called mental-exercise hypothesis, that is, the age-related decline in cognitive fun
http://www.buckinstitute.org/garrisonlab. I started my independent research group at the Buck Institute for Research on Aging in September 2013. My lab is focused on elucidating the mechanisms by which neuromodulation by neuopeptides encodes longterm changes in the brain that influence behavior and aging. Despite strong evidence showing essential functional roles for neuropeptides in both behavior and basic physiology, at the cellular level a number of questions remain. We are exploring the role of extrasynaptic neuropeptide release in behavior, and developing strategies to interrogate the spatial and temporal specificity of neuropeptide signaling using C. elegans as a whole animal model. We are particularly interested in understanding how age related changes in neuropeptide levels in specific neurons can influence whole organism longevity. Our goal is to identify general principles by which neuropeptides modify neural circuits in a simple organism, and thus illuminate neuromodulation in more ...
Caroline has 298 books on her young-adult shelf: Tempests and Slaughter by Tamora Pierce, Before the Devil Breaks You by Libba Bray, Akata Witch by Nnedi...
In advanced age, decreased CD8+ cytotoxic T-lymphocyte (CTL) responses to novel pathogens and cancer is paralleled by a decline in the number and function of naïve CTL precursors (CTLp). Although the age-related fall in CD8+ T-cell numbers is well established, neither the underlying mechanisms nor the extent of variation for different epitope specificities have been defined. Furthermore, naïve CD8+ T cells expressing high levels of CD44 accumulate with age, but it is unknown whether this accumulation reflects their preferential survival or an age-dependent driver of CD8+ T-cell proliferation. Here, we track the number and phenotype of four influenza A virus (IAV)-specific CTLp populations in naïve C57BL/6 (B6) mice during aging, and compare T-cell receptor (TCR) clonal diversity for the CD44hi and CD44lo subsets of one such population. We show differential onset of decline for several IAV-specific CD8+ T-cell populations with advanced age that parallel age-associated changes in the B6 ...
My diagnosis with Parkinsons Disease in September 2009 at age 80 gave my life a new focus and challenge. Finding ways to meet this challenge helped make 2010 the best year of my life. I hope this blog will be a place where I can connect with others who also are dealing with aging and its afflictions and attractions so that we can share our "experience, strength and hope.". ...
Hills Science Diet Mature Adult Active Longevity Original supports senior dogs health with L-carnitine, Omega-3s, glucosamine, chondroitin, and more.
Science Plan Canine Mature Adult 7+Active Longevity Mini is specially formulated to sustain mobility and healthy vital organs in dogs seven years and...
OVERALL AIM: In human and animal models, to investigate imbalances in the distribution of long chain omega-3 fatty acids (LC-omega-3) in plasma lipids and lipoproteins brought about by age and APOE4 genotype and to evaluate whether these imbalances are linked with cognitive functions. BACKGROUND: Risk of cognitive decline increases with age. Epidemiological studies strongly support a link between lower risk of cognitive decline and higher intake of fatty fish containing LC-omega-3. However, our clinical studies show that there are imbalances in the distribution of LC-omega-3 in plasma lipids that occur during aging and in the carriers of apolipoprotein E epsilon4 (APOE4) genotype, the most important genetic risk for cognitive decline. As a consequence, these imbalances appear to contribute to dysregulation of LC-omega-3 metabolism and to higher risk of cognitive decline. Our preliminary results in elderly humans show that visuospatial, verbal fluency and working memory scores are improved after ...
Aging is the single most important prognostic factor associated with the development of many diseases including cancer (1). The results described here demonstrate that aging-associated increases in inflammation negatively impact the development and function of B progenitor cells, including reductions in key indicators of cell fitness. Importantly, using two different, naturally occurring molecules to reduce inflammation in old mice, we show that preventing aging-associated reductions in B progenitor fitness abrogates selection for NRASV12-initiated progenitors. These studies highlight how inflammation-induced alterations in the adaptive landscape in old age govern the selection of oncogenically initiated cells and, ultimately, leukemogenesis within hematopoietic progenitor cell populations (Figure 8D).. In recent years, there has been growing interest in identifying factors that regulate the aging process (8, 52, 53). We observed aging-associated increases in TNF-α, IL-6, and IL-1β levels in ...
Young, healthy muscle (left column) appears pink and red. In contrast, the old muscle is marked by scarring and inflammation, as evidenced by the yellow and blue areas. This difference between old and young tissue occurs both in the muscles normal state and after two weeks of immobilization in a cast. Exercise after cast removal did not significantly improve old muscle regeneration; scarring and inflammation persisted, or worsened in many cases.
Human brain ageing is characterised by decreasing cognitive function of various severity affecting 60% of aged population. Decline in cognitive capabilities might be the only symptom of ageing in otherwise healthy humans. Even more important is ageing-related development of neurodegenerative diseases, which present a significant burden to society and the health care system. Diminished cognitive function with increased age is likely a manifestation of dysregulated synaptic function and ineffective neurotransmission. We recently reported a comparative analysis of the synaptosome transcriptome in ageing mouse brain. Our results revealed changes in expression of genes contributing to biological pathways related to neurite guidance and synaptosomal physiology (Fig. 2) as well as perturbation of long non-coding RNAs (lncRNAs). The aim of this project is to explore mechanisms which lead to reshaping of the non-coding transcriptome as a result of brain ageing. The project will employ meta-analytical and ...
By studying a particularly short-lived fish species researchers have ...The development of drugs able to retard the onset of aging-related dis...Resveratrol is an organic compound naturally present in grapes--and pa...Recently a small fish species with a captive lifespan of only three m...Resveratrol appears to be the first molecul...,Resveratrol,prolongs,lifespan,and,delays,onset,of,aging-related,traits,in,a,short-lived,vertebrate,biological,biology news articles,biology news today,latest biology news,current biology news,biology newsletters
Four images, two girls - and a story. Its all in the mind; think about it. It was a hot day, the grass was very dry and they were both very thirsty, but Joanne and her small group had walked the pair all the way over to where the big, old, wooden... ...
A study has found that the degeneration of a small, wishbone-shaped structure deep inside the brain may provide the earliest clues to future cognitive decline.
Brain aging is characterized by global changes which are thought to underlie age-related cognitive decline. These include variations in brain activity and the progressive increase in the concentration of soluble amyloid-β (Aβ) oligomers, directly impairing synaptic function and plasticity even in the absence of any neurodegenerative disorder. Considering the high social impact of the decline in brain performance associated to aging, there is an urgent need to better understand how it can be prevented or contrasted. Lifestyle components, such as social interaction, motor exercise and cognitive activity, are thought to modulate brain physiology and its susceptibility to age-related pathologies. However, the precise functional and molecular factors that respond to environmental stimuli and might mediate their protective action again pathological aging still need to be clearly identified. To address this issue, we exploited environmental enrichment (EE), a reliable model for studying the effect of
American Federation for Aging Research. Determining and manipulating age-dependent changes in myocardial stiffness, in vivo. The specific aims of the project are: 1) Identify differences in potential collective, age-related myocardial stiffening events among multiple Drosophila control lines. We will ascertain passive mechanical differences in young vs. old fly hearts from several control strains including Oregon-R, w1118, Canton-S and GMH5-GAL4 x yw. 2) Investigate the effect of aging on passive mechanical properties of Drosophila myocardium with cardiac-specific overexpression of the transcription factor FOXO, which is known to rejuvenate cardiac performance and promote muscle proteostasis in senescent flies. 3) Employ targeted, cardiac-specific RNA interference to improve morphology, performance and mechanics of senescent hearts. ...
Methods From January 2011 to January 2013, totally 112 elderly patients with AMI, 67 males and 45 females, age 60 to 86 (mean 65.6 ± 5.8), were selected as AMI group. 113 cases of healthy elderly people were selected as control group. IL18 and hs-CRP were detected in fasting venous blood in the early morning from healthy elderly people or on the next day morning after admission from AMI patients.. ...
Click here for lab homepage:Dr. Roberson is a neurologist and neuroscientist whose research is focused on age-related cognitive impairment. He...
OBJECTIVES: To use the Medicare Files of Service Use (MFSU) to evaluate patterns in the incidence of aging-related diseases in the U.S. elderly population. DESIGN: Age-specific incidence rates of 19 aging-related diseases ...
The American Aging Association is a group of experts dedicated to understanding the basic mechanisms of aging to enable methods of preserving and restoring function lost to age-related degeneration in order to extend the healthy human lifespan. Become a member here.. ...
본 연구는 연령이 증가함에 따라 나타나는 지방대사의 변화에 대하여 식이내 단백질수준이 어떻게 영향을 미치는가를 관찰하고저 행하여졌다. 실험동물은 평균체중이 70.4±2.4g (생후 4주)과 287.1±6.3g(생후 5~6개월)인 Wistar종 수컷 흰쥐 48마리를 연령에 따라 어린군(Young Group)과 성숙한 군(Adult Group)으로 나누었고 각 연령군을 7%, 15%, 50%로 단백질 수준을 각각 달리하여 5주간 사육하였다. 본 실험의 결과들을 요약해 보면 다음과 같다. 체중 100g당 식이 섭취량과 단백질 효율은 연령의 차이없이 7% 단백질군이 50%단백질군에 비해 유의적으로 높았고 체중 증가량은 두 연령군 모두 50% 단백질군에서 가장 높았다. 지방의 흡수율은 성숙한 쥐가 어린쥐보다 약간 낮았고, 단백질수준이 증가할수록 각 연령군 모두에서 낮아졌다. 혈청내 총지방량, 총콜레스테롤 및 ...
The normal age variation in left ventricular parameters in males (left) and females (right). Solid lines represent rational polynomial curve fit and dashed line
Muenchhoff J; Song F; Poljak A; Crawford JD; Mather KA; Kochan NA; Yang Z; Trollor JN; Reppermund S; Maston K, 2017, Plasma apolipoproteins and physical and cognitive health in very old individuals, Neurobiology of Aging, vol. 55, pp. 49 - 60, http://dx.doi.org/10.1016/j.neurobiolaging.2017.02.017. Tsang RSM; Mather KA; Sachdev PS; Reppermund S, 2017, Systematic review and meta-analysis of genetic studies of late-life depression, Neuroscience and Biobehavioral Reviews, vol. 75, pp. 129 - 139, http://dx.doi.org/10.1016/j.neubiorev.2017.01.028. Hibar DP; Adams HHH; Jahanshad N; Chauhan G; Stein JL; Hofer E; Renteria ME; Bis JC; Arias-Vasquez A; Ikram MK, 2017, Novel genetic loci associated with hippocampal volume, Nature Communications, vol. 8, http://dx.doi.org/10.1038/ncomms13624. Lipnicki DM; Crawford J; Kochan NA; Trollor JN; Draper B; Reppermund S; Maston K; Mather KA; Brodaty H; Sachdev PS, 2017, Risk Factors for Mild Cognitive Impairment, Dementia and Mortality: The Sydney Memory and ...
Medical supplies for the elderly are especially helpful for allowing aged individuals to perform satisfactorily in the bathroom - including shower, tub, and toilet.
brain areas. Acetylcholine also seems to play a crucial role The incidence of POD varies between 5.1% and 52.5% in the development of POD due to its various roles in the in elderly patients undergoing major surgery, and certain regulation of cerebral functions, including motor activity, procedures such as hip fracture or aortic surgery having higher rapid eye movement (REM) sleep, mood, attention, and risk of POD4,5,7,8,21,22,27). Because there has been practically memory. Thus, the lack of acetylcholine or relative excess no neurosurgical literature on the incidence of POD, we of dopaminergic transmission seems to be connected to could not compare the 21.4% incidence in our study with the development of POD. The age-dependent decrease of that from similar studies. We could only assume that the acetylcholine transmission is a physiologic process, and incidence was not much higher than expected. Several reduced "cholinergic reserve" may be responsible for the contributing factors such as ...
Aging is associated with decreased expansion of T cells upon stimulation. By using influenza virus, LCMV and TCR transgenic mice, I am working on the mechanisms of impairment of specific CD8 T cell response in aged mice, which may have an important implication for understanding the alteration of immune response in aged individuals.. ...
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Development of Valid Reliable Markers of Aging-Related Biologic Mechanisms for Human Studies (U01) RFA-AG-18-018. NIA
GenDR A curated database of genes associated with dietary restriction in model organisms either from genetic manipulation experiments or gene expression profiling.. ...
GenDR A curated database of genes associated with dietary restriction in model organisms either from genetic manipulation experiments or gene expression profiling.. ...
Big biology news today: three teams of scientists (from UNC, Michigan and Hahvahd) jointly published work that hints at the incredibly complex balance of cell proliferation, aging and cancer. The groups each worked with a particular tumor suppressor, p16INK4a, in different tissues. The genes expression gradually increases with age, and its increased expression seems not only to prevent age-related out-of-control cell growth (cancer=bad), but also prevents stem-cell proliferation (stem cells=good). Its a fascinating and tricky balance. Tumor suppression is increasingly important as we age, but the flip side of that is a loss of the stem cells that are so important for renewing our tissues. I supposed the debate turns to whether wed rather get cancer or have garden-variety age-related degeneration. From the linked NYT article, one of the lead scientists summed it up optimistically ...
Mitochondrial dysfunction frequently occurs in aged individuals and is a hallmark of diseases such as Parkinsons, Alzheimers, cancer, and diabetes. Organisms...
ContextAlthough depression is associated with increased cardiovascular morbidity and mortality, there is virtually no information on whether it also increases t
Eggs are also a rich source of antioxidants like lutein and zeaxanthin, which improve the health of the retina and prevent macular degeneration and age-related disorders related to the eyes
Global Oral X-Ray Machines Market is driven by rising number of aged individuals suffering from periodontal diseases. Market for Oral X-Ray Machines is dominated by North America .
Today acne is one of the most typical skin complaints that both young and old individuals will have to deal with at some point in their lives. Unfortunatel
Confocal images of coronal subventricular zone (SVZ) sections showing that 22-month-old mice injected with rGDF11 for 4 weeks have (A) enhanced vascularization
A new study on UHT milk is helping scientists to better understand Alzheimers, Parkinsons and type 2 diabetes, opening the door to improved treatments for these age-related diseases.
The heart holds its own pool of immune cells capable of helping it to heal after injury, finds research, adding that the harmful immune cells from the bone marrow disrupts this process in adults.
As an active mom who ate right and exercised on her lunch hour, Lorie Helgeson had no reason to think that she would have a heart attack. Paying attention to her symptoms and getting to a doctor saved her life.
The prominent factors propelling the growth of the global qPCR reagents market include increasing patient population for genetic disorders and infectious diseases, the rise in aged population, and advancement in technologies in the life sciences domain.
Anti-Aging Super HGH Reviews and other Reviews of Nutritional Supplements and Merchants Plus Related Resources Including a 2017 Buying Guide. Healthy Learning for Healthy Living.
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Humorous views on interesting, bizarre and amusing articles, submitted by a community of millions of news junkies, with regular Photoshop contests.
Research focus. My ultimate ambition is to better understand immunosenescence and immune dysregulation over the trajectory of aging, and how these changes relate to compromised health and quality of life in old age. This is particularly important since over the next several decades the world will undergo an unprecedented increase in the proportion of adults over the age of 65. Hence, strategies to promote healthy aging will be critical to minimize the social and economic burdens that are normally associated with elder care. Implicit to this goal is a continual advancement of our understanding of the biology of aging. My research focus features a comprehensive approach that combines epidemiological techniques to identify inherent and modifiable risk factors of age-related disease and morbidity, and in vitro and ex vivo molecular methods to examine potential biological mechanisms. This approach often features immune and inflammation related soluble and cell-associated biomarkers that not only ...
In summary, the research of my laboratory is primarily on age-related degenerative diseases that are characterized by protein conformational changes. It involves studying this alteration, its consequences at the molecular- and system level, the factors that are involved in this process, as well as therapeutic and diagnostic targeting of this pathological pathway.. ...
How TV Shows like Scream Fuel the Young Adult Horror Surge By Dawn Ius Carolyn Lee Adams didnt write Ruthless with the intent of getting it published. Instead, her chilling young-adult debut began as a way to cope with the claustrophobic darkness invading her own life. My marriage was falling apart and this novel
As your Configuration Manager 2007 site performs the tasks that you schedule and configure, site components continually add data to the sites database. As the amount of data grows, database performance declines.. Predefined maintenance tasks target the Configuration Manager 2007 site database and continually remove out-of-date data. Reducing the size of the database by removing unnecessary data improves the performance and the integrity of the database, which increases the efficiency of the site.. Primary sites have all of the predefined maintenance tasks available as listed below. The only predefined maintenance task available for secondary sites however, is the Backup Site Server maintenance task.. ...
talk , contribs)‎ (→‎Wikimedia content copied into an external for-profit stock photograph database.: I suppose the problem is that they are charging people to license public domain images originally curated here. To a lesser extent, they are also copying image names,) ...
talk , contribs)‎ (→‎Wikimedia content copied into an external for-profit stock photograph database.: I suppose the problem is that they are charging people to license public domain images originally curated here. To a lesser extent, they are also copying image names,) ...
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Hills Science Plan™ Feline Mature Adult 7+ Youthful Vitality Food is available online with fast delivery from VioVet, the trusted supplier of veterinary medication, foods and animal care products.
The Cologne Cluster of Excellence in Cellular Stress Responses in Aging-associated Diseases provides an extremely dynamic environment for research into the aging process and its diseases.
The Cologne Cluster of Excellence in Cellular Stress Responses in Aging-associated Diseases provides an extremely dynamic environment for research into the aging process and its diseases.
Zur Erfassung altersspezifischer Veränderungen peripherer Hörbahnstationen wurden akustisch evozierte Hirnstammantworten bei Meerschweinchen zweier Altersstufen untersucht. Da Angaben über...
Making some small changes to your lifestyle as you age can help reduce your chance of certain age-related diseases and help keep you feeling - and looking - younger. The Natures Way range of products for people aged 50+ can help.
Skeletal muscle undergoes a progressive age-related loss in mass and function. Preservation of muscle mass depends in part on satellite cells, the resident stem cells of skeletal muscle. Reduced satellite cell function may contribute to the age-associated decrease in muscle mass. Here, we focused on characterizing the effect of age on satellite cell migration. We report that aged satellite cells migrate at less than half the speed of young cells. In addition, aged cells show abnormal membrane extension and retraction characteristics required for amoeboid-based cell migration. Aged satellite cells displayed low levels of integrin expression. By deploying a mathematical model approach to investigate mechanism of migration, we have found that young satellite cells move in a random "memoryless" manner, whereas old cells demonstrate superdiffusive tendencies. Most importantly, we show that nitric oxide, a key regulator of cell migration, reversed the loss in migration speed and reinstated the ...
TY - JOUR. T1 - Age-related susceptibility to apoptosis in human retinal pigment epithelial cells is triggered by disruption of p53-Mdm2 association.. AU - Bhattacharya, Sujoy. AU - Chaum, Edward. AU - Johnson, Dianna A.. AU - Johnson, Leonard R.. PY - 2012/1/1. Y1 - 2012/1/1. N2 - Relatively little is known about the contribution of p53/Mdm2 pathway in apoptosis of retinal pigment epithelial (RPE) cells or its possible link to dysfunction of aging RPE or to related blinding disorders such as age-related macular degeneration (AMD). Age-associated changes in p53 activation were evaluated in primary RPE cultures from human donor eyes of various ages. Apoptosis was evaluated by activation of caspases and DNA fragmentation. Gene-specific small interfering RNA was used to knock down expression of p53. We observed that the basal rate of p53-dependent apoptosis increased in an age-dependent manner in human RPE. The age-dependent increase in apoptosis was linked to alterations in several aspects of the ...
Published on: October 27, 2014. by Medical XPress:. Dietary cocoa flavanols-naturally occurring bioactives found in cocoa-reversed age-related memory decline in healthy older adults, according to a study led by Columbia University Medical Center (CUMC) scientists. The study, published today in the advance online issue of Nature Neuroscience, provides the first direct evidence that one component of age-related memory decline in humans is caused by changes in a specific region of the brain and that this form of memory decline can be improved by a dietary intervention.. As people age, they typically show some decline in cognitive abilities, including learning and remembering such things as the names of new acquaintances or where one parked the car or placed ones keys. This normal age-related memory decline starts in early adulthood but usually does not have any noticeable impact on quality of life until people reach their fifties or sixties. Age-related memory decline is different from the ...
BACKGROUND: Leukocyte telomere length, a putative marker of ageing, is a highly variable and heritable complex trait. In order to determine the possible underlying genetic variants for leukocyte telomere length variation, we conducted an association study of leukocyte telomere length and two candidate genes for ageing-related traits, TGFB1 and KLOTHO, in a female Caucasian dizygotic twin population. METHODS AND MATERIALS: Terminal restriction fragment (TRF) length, an index of telomere length, was measured using Southern Blotting. Six and four single nucleotide polymorphisms (SNP) were genotyped in TGFB1 and KLOTHO gene, respectively, and tested for association. When there is strong LD between SNPs (r(2) , 0.5), haplotypic association was investigated using haplotype trend regression approach. RESULTS: All SNPs were in Hardy-Weinberg equilibrium (p , 0.05). No significant association was detected for individual SNPs (p , 0.101), or two-locus haplotypes (p = 0.7497) with TRF variation. ...
Our results demonstrate that neither the deletion of Bax gene nor over-expression of Bcl-2 in hair cells and SGNs delays age-related hearing loss. Despite Bax-/- or overexpression of Bcl-2 in hair cells and SGNs, age-related death of these cells still occurred at a rate similar to the cells in wild-type controls. Thus, our data challenges the position that the apoptosis pathway involving the Bac-2 family is the molecular mechanism underlying normal age-related neuronal loss.. Since it is still uncertain whether there is age-related neuronal loss in the central nervous system, it is difficult to interpret changing expression levels of various apoptotic genes in the brain during aging [17, 36]. However, in the cochlea, age-related loss of hair cells and SGNs are consistently observed across species [5, 6, 8]. Several studies have suggested a role for apoptosis in age-related loss of hair cells and SGNs. Using the terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end-labeling (TUNEL) ...
1. Since ageing has been associated with a decrease in both immune responses and antioxidant defences, this study was undertaken to compare the glutathione peroxidase activity in peripheral blood mononuclear cells of healthy elderly and young donors. The mean value of glutathione peroxidase activity was significantly lower in the aged group (−36%) than that observed in the young control group (n = 10).. 2. This defect was accompanied by a marked increase (+106%) in the oxygenated metabolism of endogenous arachidonic acid by lipoxygenases as judged by the radiolabel associated with hydroxyeicosatetraenoic acids in [3H]arachidonic acid-prelabelled peripheral blood mononuclear cells, whereas the cyclo-oxygenase activity, estimated by the radiolabel associated with thromboxane B2, was not significantly altered.. 3. Upon stimulation by the mitogenic lectin concanavalin A, the radioactivity associated with total eicosanoids (free arachidonic acid plus hydroxyeicosatetraenoic acids plus thromboxane ...
Our natural body odor goes through several stages of age-dependent changes in chemical composition as we grow older. Similar changes have been reported for several animal species and are thought to facilitate age discrimination of an individual based on body odors, alone. We sought to determine whether humans are able to discriminate between body odor of humans of different ages. Body odors were sampled from three distinct age groups: Young (20-30 years old), Middle-age (45-55), and Old-age (75-95) individuals. Perceptual ratings and age discrimination performance were assessed in 41 young participants. There were significant differences in ratings of both intensity and pleasantness, where body odors from the Old-age group were rated as less intense and less unpleasant than body odors originating from Young and Middle-age donors. Participants were able to discriminate between age categories, with body odor from Old-age donors mediating the effect also after removing variance explained by intensity
Cataract surgery is the removal of the natural lens of the eye (also called "crystalline lens") that has developed an opacification, which is referred to as a cataract. Metabolic changes of the crystalline lens fibers over time lead to the development of the cataract and loss of transparency, causing impairment or loss of vision. In addition to these age related changes, infants may be born with congenital cataracts. Direct ocular trauma and some medications, specifically the long term use of steroids, may also result in cataract formation. Long term exposure to infrared light and microwave radiation may also lead to cataract formation. Many peoples first symptoms are strong glare from lights and small light sources at night, along with reduced acuity at low light levels. During cataract surgery, a patients cloudy natural cataract lens is removed and replaced with a synthetic lens to restore the lenss transparency. Following surgical removal of the natural lens, an artificial intraocular lens ...
Zoher Kapasi, PhD, PT, MBA is the Director and Professor in the Division of Physical Therapy of the Department of Rehabilitation Medicine at Emory University School of Medicine in Atlanta, Georgia. He received his Bachelors and Masters Degrees in Physical Therapy from University of Bombay, India, PhD in Anatomy/Immunobiology from Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia and Executive MBA from Goizueta Business School, Emory University, Atlanta. He did post-doctoral work in Immunology at Basel Institute for Immunology, Switzerland and Medical College of Virginia. His research focuses on age-related changes in immune function and the effects of exercise and nutrition on the immune system. Additionally, Dr. Kapasi is researching determinants of referrals for physical therapy in a private practice setting (marketing studies). Dr. Kapasi teaches human anatomy, advanced human anatomy and business management for the physical therapist in the physical therapy ...

Study Examines Public Health Effects of the Minimum Legal Drinking Age | National Institute on Alcohol Abuse and Alcoholism ...Study Examines Public Health Effects of the Minimum Legal Drinking Age | National Institute on Alcohol Abuse and Alcoholism ...

Some people argue that the current age-21 drinking limit in the United States is ... including those who are below the legal drinking age of 21. ... Some people argue that the current age-21 drinking limit in the ... They estimate that lowering the MLDA to 18 would result in an additional 8 deaths per 100,000 person years for the 18-20 age ... Alcohol consumption and its harms are common among young people, including those who are below the legal drinking age of 21. ...
more infohttps://www.niaaa.nih.gov/research/niaaa-research-highlights/study-examines-public-health-effects-minimum-legal-drinking-age

National Institute on AgingNational Institute on Aging

on health & aging & Alzheimers. Get research news & funding opportunities from the National Institute on Aging at NIH. ... Global Aging. Find information on research into global trends in aging and aging-related diseases. ... Aging Research Advances. Since its founding in 1974, NIA research has changed the way America understands aging. ... Baltimore Longitudinal Study of Aging. The Baltimore Longitudinal Study of Aging is Americas longest-running scientific study ...
more infohttps://www.nia.nih.gov/

Sleep Deprivation Linked To Aging Skin, Study Suggests | HuffPostSleep Deprivation Linked To Aging Skin, Study Suggests | HuffPost

Now heres another good reason to get enough sleep: sleep deprivation also could cause your skin to age faster, according to a ... The amount of sleep one needs depends on a persons age. Most experts recommend that adults get between seven and eight hours ... The study involved 60 pre-menopausal women between the ages of 30 and 49, with half of them falling into the poor quality sleep ... Sleep deprived women show signs of premature skin aging and a decrease in their skins ability to recover after sun exposure," ...
more infohttps://www.huffingtonpost.com/2013/07/24/sleep-deprivation-effects-aging-skin_n_3644269.html

What Is Macular Degeneration? - American Academy of OphthalmologyWhat Is Macular Degeneration? - American Academy of Ophthalmology

Age-related macular degeneration (AMD) is a problem with your retina. It happens when a part of the retina called the macula is ... Age-related macular degeneration (AMD) is a problem with your retina. It happens when a part of the retina called the macula is ... Dry AMD is when parts of the macula get thinner with age and tiny clumps of protein called drusen grow. You slowly lose central ...
more infohttps://www.aao.org/eye-health/diseases/amd-macular-degeneration

Skin Care and AgingSkin Care and Aging

These anti-aging skin-care tips can help you prevent or manage wrinkles, age spots, and dry skin-and avoid skin cancer, too. ... Age Spots and Skin Tags. Age spots, once called "liver spots," are flat, brown spots often caused by years in the sun. They are ... Age spots and skin tags are harmless, although sometimes skin tags can become irritated. If your age spots or skin tags bother ... Losing sweat and oil glands, which is common with age. Dry skin also can be caused by health problems, such as diabetes or ...
more infohttps://www.nia.nih.gov/health/skin-care-and-aging

The Middle Ages: Feudal LifeThe Middle Ages: Feudal Life

or safety and for defense, people in the Middle Ages formed small communities around a central lord or master. Most people ...
more infohttp://www.learner.org/interactives/middleages/feudal.html

Age of Autism Awards 2010: Dr. Paul Offit, Denialist of the Decade - AGE OF AUTISMAge of Autism Awards 2010: Dr. Paul Offit, Denialist of the Decade - AGE OF AUTISM

... after which an age-related decline dominates in the elderly. Based on a realistic age-structured model, we compare differences ... Posted by Age of Autism on December 29, 2010 at 05:45 AM in Abdulkadir Khalif, Anne Dachel, Cathy Jameson, Current Affairs, Dan ... Age of Autism Awards 2010: Dr. Paul Offit, Denialist of the Decade By Dan Olmsted ... He should wear his black hooded cloak and carry his sickle when he recieves this award for Monster of the Decade from Age of ...
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Tooth loss in middle age linked to heart disease | ReutersTooth loss in middle age linked to heart disease | Reuters

Reuters Health) - Losing two or more natural teeth in middle age may signal an increased risk for coronary heart disease, a U.S ... Reuters Health) - Losing two or more natural teeth in middle age may signal an increased risk for coronary heart disease, a U.S ... "Thats regardless of the number of natural teeth a person has as a middle-aged adult, or whether they have traditional risk ... "In addition to other established associations between dental health and risk of disease, our findings suggest that middle-aged ...
more infohttps://uk.reuters.com/article/us-tooth-loss-heart-disease/tooth-loss-in-middle-age-linked-to-heart-disease-idUKKBN1HP2QN

Understanding of gravity in the Middle Ages | Physics Forums - The Fusion of Science and CommunityUnderstanding of gravity in the Middle Ages | Physics Forums - The Fusion of Science and Community

I would say yes if you are talking about a temporal frame of reference, i.e. Middle Ages vs. Information Age. ... Similar Discussions: Understanding of gravity in the Middle Ages * Middle of gravity (Replies: 5) ... I have read that in the Middle Ages people believed that angels pushed the Moon in its orbit, the angelic push presumably being ... What else did people in the Middle Ages know about gravity? Did they, for example, know that the same force which was ...
more infohttps://www.physicsforums.com/threads/understanding-of-gravity-in-the-middle-ages.936516/

Home - National Asian Pacific Center on AgingHome - National Asian Pacific Center on Aging

Today, NAPCA continues to be the voice of AAPI older adults and their families as leaders in the areas of healthy aging, mature ... On November 1, 1979, a small federal grant gave birth to the National Asian Pacific Center on Aging. The dream of a national ... AAPI older adults are the second largest racial labor force participation group at 63.4%. With the aging of the AAPI senior ... and quality of life of Asian Americans and Pacific Islanders as they age ...
more infohttp://napca.org

Randomised trial of a parent-mediated intervention for infants at high risk for autism: longitudinal outcomes to age 3 years.  ...Randomised trial of a parent-mediated intervention for infants at high risk for autism: longitudinal outcomes to age 3 years. ...

Randomised trial of a parent-mediated intervention for infants at high risk for autism: longitudinal outcomes to age 3 years.. ... Randomised trial of a parent‐mediated intervention for infants at high risk for autism: longitudinal outcomes to age 3 years ... Randomised trial of a parent‐mediated intervention for infants at high risk for autism: longitudinal outcomes to age 3 years ... Randomised trial of a parent‐mediated intervention for infants at high risk for autism: longitudinal outcomes to age 3 years ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/28393350

Healthy Ageing and Aged CareHealthy Ageing and Aged Care

Each print copy of Healthy Ageing and Aged Care comes with a free code that can be activated at www.oxfordascend.com to access ... Healthy Ageing and Aged Care takes an inter-disciplinary approach to supporting older people within the community and in care. ... The following resource is available for lecturers using Healthy Ageing and Aged Care:. Instructors Resource Manual built ... Helen Small has been employed as the general manager operations at Wintringham Specialist Aged Care for the last twelve years. ...
more infohttps://www.oup.com.au/books/higher-education/health,-nursing-and-social-work/9780195597585-healthy-ageing-and-aged-care

Movement: 8 to 12 Months - HealthyChildren.orgMovement: 8 to 12 Months - HealthyChildren.org

At about a year of age, when your baby has become a competent crawler, teach her to go down real stairs backward. She may take ... Caring for Your Baby and Young Child: Birth to Age 5 (Copyright © 2009 American Academy of Pediatrics). The information ...
more infohttps://www.healthychildren.org/English/ages-stages/baby/Pages/Movement-8-to-12-Months.aspx

Relaxing Piano Music -Instrumental Music - Spa Music - Inner Peaceful Music - Christmas Music : My Peaceful World by Shirley...Relaxing Piano Music -Instrumental Music - Spa Music - Inner Peaceful Music - Christmas Music : My Peaceful World by Shirley...

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Memory and aging - WikipediaMemory and aging - Wikipedia

"Psychology and Aging. American Psychological Association. Retrieved 9 May 2011.. *^ Kahana, Michael. "Age Dissociates Recency ... Normal aging[edit]. Normal aging is associated with a decline in various memory abilities in many cognitive tasks; the ... Age-related memory loss, sometimes described as "normal aging", is qualitatively different from memory loss associated with ... As they age, their ability to multi-task seems to decline; thus after an interruption it is often more difficult for an aging ...
more infohttps://en.wikipedia.org/wiki/Memory_and_aging

Sponsored Collection | A new age in scanning electron microscopy: Applications in the life sciences | ScienceSponsored Collection | A new age in scanning electron microscopy: Applications in the life sciences | Science

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CataractsCataracts

But as we age, some of the protein may clump together and start to cloud a small area of the lens. This is a cataract. Over ... But during middle age, most cataracts are small and do not affect vision. It is after age 60 that most cataracts cause problems ... Most cataracts are related to aging. Cataracts are very common in older people. By age 80, more than half of all Americans ... But as we age, some of the protein may clump together and start to cloud a small area of the lens. This is a cataract. Over ...
more infohttps://nei.nih.gov/health/cataract/cataract_facts

Age In Place | The National Aging In Place CouncilAge In Place | The National Aging In Place Council

S.C. Aging in Place Coalition Transitions to National Aging in Place Greater Charleston Chapter CHARLESTON, SC - To better ... the South Carolina Aging in Place Coalition has become a Chapter of the National Aging in ... Read More ... What to Expect in your 50s, 60s, and 70s As we age, our health needs are constantly changing. Knowing what to expect as you ... serve the community and help individuals find the resources to age in place, ...
more infohttp://www.ageinplace.org

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Just Dont Call it ImmortalityJust Don't Call it Immortality

Are germ cells immune to aging?. Yes and no. They definitely do age, but not to the same extent as other cell types. In males, ... we may be able to tease that mechanism apart and use it to reset the clock of the cells as a therapy for aging and aging- ... which means it can become any other cell of the body-and you also revert the age of that cell to the youngest age possible. ... Does Aging Have a Reset Button?. A Stanford researchers new take on stem cells. Victor Gomes By Victor Gomes February 1, 2018 ...
more infohttp://nautil.us/issue/57/communities/does-aging-have-a-reset-button

Unintentional Drowning: Get the Facts | Home and Recreational Safety | CDC Injury CenterUnintentional Drowning: Get the Facts | Home and Recreational Safety | CDC Injury Center

Location: People of different ages drown in different locations. For example, most children ages 1-4 drown in home swimming ... Children: Children ages 1 to 4 have the highest drowning rates. In 2014, among children 1 to 4 years old who died from an ... Taking part in in formal swimming lessons reduces the risk of drowning among children aged 1 to 4 years.9,10 However, many ... Of these, two are children aged 14 or younger. Drowning ranks fifth among the leading causes of unintentional injury death in ...
more infohttps://www.cdc.gov/homeandrecreationalsafety/water-safety/waterinjuries-factsheet.html

aging-giaging-gi

In a study conducted to understand the effect of aging on carbohydrates digestion and absorption, both older and younger age ... manometric studies of the colon in the elderly fail to identify any age-related decrease in the motility. In the aged colon, ... but not in the younger age groups (3) . Finally, the brush border peptidases seem also to remain intact with older age, and ... it is worth mentioning that serum insulin levels increase with age, but the sensitivity to insulin diminishes with age (1) . ...
more infohttp://www.angelfire.com/ky/IBMS/aginggi.html

aging | PNASaging | PNAS

Menopause accelerates biological aging Morgan E. Levine, Ake T. Lu, Brian H. Chen, Dena G. Hernandez, Andrew B. Singleton, ... Hhip haploinsufficiency sensitizes mice to age-related emphysema Taotao Lao, Zhiqiang Jiang, Jeong Yun, Weiliang Qiu, Feng Guo ... Chromatin-modifying genetic interventions suppress age-associated transposable element activation and extend life span in ...
more infohttp://www.pnas.org/keyword/aging?page=4

aging - Wiktionaryaging - Wiktionary

aging (comparative more aging, superlative most aging) *Becoming elderly. The aging artist could no longer steadily hold the ... Retrieved from "https://en.wiktionary.org/w/index.php?title=aging&oldid=50662981" ...
more infohttps://en.wiktionary.org/wiki/aging

Aging | SpringerLinkAging | SpringerLink

... from the mitotic age of cells to the organismal-wide aging of tissues and organs. The appearance of cancer is only one clinical ... Aging is defined at many levels, from the mitotic age of cells to the organismal-wide aging of tissues and organs. The ... Aging. During an organisms life span almost every aspect of its phenotype will undergo modification. The complexity of aging ... Age-associated epithelial cancers, such as breast cancer, colon cancer, and prostate cancer, however, contribute significantly ...
more infohttps://link.springer.com/referenceworkentry/10.1007/978-3-642-27841-9_143-2
  • In addition to other established associations between dental health and risk of disease, our findings suggest that middle-aged adults who have lost two or more teeth in recent past could be at increased risk for cardiovascular disease," Dr. Lu Qi of Tulane University in New Orleans said in a statement. (reuters.com)
  • Today, NAPCA continues to be the voice of AAPI older adults and their families as leaders in the areas of healthy aging, mature workers, and the prevention of elder abuse. (napca.org)
  • With the aging of the AAPI senior population, this implies that many AAPI older adults will either enter or remain in the labor force. (napca.org)
  • Furthermore, the older adults' performances in free recall involved temporal contiguity to a lesser extent than for younger people, indicating that associations regarding contiguity become weaker with age. (wikipedia.org)
  • National, ongoing, health promotion designed to broaden awareness of the positive aspects of aging and to provide inspiration to adults, ages 50 plus, to improve their physical, mental, social and financial health. (dmoztools.net)
  • Campisi J (2005) Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors. (springer.com)
  • Age-associated epithelial cancers, such as breast cancer , colon cancer, and prostate cancer , however, contribute significantly to the morbidity and mortality of the elderly and are the second leading cause of death. (springer.com)
  • According to the National Alliance for Caregiving (NAC), there are 44 million family caregivers, which is nearly 20 percent of the adult population in the U.S. These caregivers, who are often over the age of 50, provide physical and financial assistance to their elderly loved ones-the NAC also found that while women provide the lion's share of basic care, men also provide financial assistance. (psychologytoday.com)
  • There are many organizations dedicated to research on aging, advocating for the elderly, and promoting healthy aging. (asha.org)
  • A two-site, two-arm assessor-blinded randomised controlled trial (RCT) of a 12-session parent-mediated social communication intervention delivered between 9 and 14 months of age (Intervention in the British Autism Study of Infant Siblings-Video Interaction for Promoting Positive Parenting), against no intervention. (nih.gov)
  • By age 80, more than half of all Americans either have a cataract or have had cataract surgery. (nih.gov)
  • Between 1999-2010, the fatal unintentional drowning rate for African Americans was significantly higher than that of whites across all ages. (cdc.gov)
  • For data on the lives of older Americans and their families, see Older Americans 2008: Key Indicators of Well-Being from the Federal Interagency Forum on Aging-Related Statistics. (asha.org)
  • Reuters Health) - Losing two or more natural teeth in middle age may signal an increased risk for coronary heart disease, a U.S. study suggests. (reuters.com)
  • What to Expect in your 50's, 60's, and 70's As we age, our health needs are constantly changing. (ageinplace.org)
  • Since its founding in 1974, NIA research has changed the way America understands aging. (nih.gov)
  • This research shows for the first time, that poor sleep quality can accelerate signs of skin aging and weaken the skin's ability to repair itself at night," said Dr. Daniel Yarosh, a senior vice president at The Estée Lauder Companies, in a press release. (huffingtonpost.com)
  • His own research program is nothing if not ambitious: He wants to reverse aging in humans. (nautil.us)
  • What impact will your work have on aging research? (nautil.us)
  • 7,8 Research has shown that participation in formal swimming lessons can reduce the risk of drowning among children aged 1 to 4 years. (cdc.gov)
  • It was established in 2002 and the editors-in-chief are Peter Adams (University of Glasgow), Adam Antebi (Max Planck Institute for Biology of Ageing), Ana Maria Cuervo (Albert Einstein College of Medicine), Brian Kennedy (Buck Institute for Research on Aging), and John Sedivy (Brown University). (wikipedia.org)
  • Government site with information on research and practical resources for the aging population. (dmoztools.net)
  • Sleep deprived women show signs of premature skin aging and a decrease in their skin's ability to recover after sun exposure," Baron said in a press release. (huffingtonpost.com)
  • Your gift in any amount helps us in our mission to serve as the nation's leading advocacy and service organization committed to the dignity, well-being, and quality of life of AAPIs as they age. (napca.org)
  • Life extension strategies often study the causes of aging and try to oppose those causes in order to slow aging. (wikipedia.org)
  • While working later in life may seem prudent financially, most people do not continue to work past the typical retirement age. (psychologytoday.com)
  • This includes sub-categories covering anti-aging, life expectancy, and the life cycle. (dmoztools.net)
  • A clinical trial commissioned by Estée Lauder and conducted by physician-scientists at University Hospitals (UH) Case Medical Center found that poor sleepers demonstrated increased signs of skin aging . (huffingtonpost.com)
  • Kirkwood TB (2005) Understanding the odd science of aging. (springer.com)
  • Years of sun tanning or being out in the sunlight for a long time may lead to wrinkles, dryness, age spots, and even cancer . (nih.gov)
  • Age spots, once called "liver spots," are flat, brown spots often caused by years in the sun. (nih.gov)
  • During the age work, she tells some years that bob and legally lee sold their consultation to paul, prompting the levitra to attack them. (topfishinggames.com)
  • According to Scopus/Scimago Journal Rank (2015), Aging is ranked number 3 on Cites/Docs (2 years) in the Aging category. (wikipedia.org)
  • 1,2 Among children ages 1 to 4, most drownings occur in home swimming pools. (cdc.gov)
  • But as we age, some of the protein may clump together and start to cloud a small area of the lens. (nih.gov)
  • Most age-related cataracts develop from protein clumpings. (nih.gov)
  • You will find special Aging in Atlanta sections in your Sunday AJC newspaper as well as see invites to our lunch and learn event series. (ajc.com)
  • sleep deprivation also could cause your skin to age faster , according to a new study. (huffingtonpost.com)
  • The study involved 60 pre-menopausal women between the ages of 30 and 49, with half of them falling into the poor quality sleep category. (huffingtonpost.com)
  • These connections between sleep and skin aging, now supported with solid scientific data, will have a profound effect on how we study skin and its functions. (huffingtonpost.com)
  • In particular, associative learning, which is another type of episodic memory, is vulnerable to the effects of aging, and this has been demonstrated across various study paradigms. (wikipedia.org)
  • Focuses on promoting the scientific study of aging. (dmoztools.net)
  • The department, of the Virginia Commonwealth University, offering an M.S. in Gerontology, as well as a postgraduate Certificate in Aging Studies. (dmoztools.net)
  • Price questions 6 do you believe it will be generic to age to buy viagra issue prescribing viagra to accompany viagra contact? (topfishinggames.com)
  • Using aging schedules can help companies spot cash flow problems before they become an even bigger issue. (investopedia.com)
  • The amazing thing is that if you take an aged cell that is fully committed to a certain function, and you transplant its nucleus into an immature egg cell called an oocyte, then you revert its function to a pluripotent, embryonic one, which means it can become any other cell of the body-and you also revert the age of that cell to the youngest age possible. (nautil.us)
  • Aging Cell is a peer-reviewed scientific journal and an official journal of the Anatomical Society. (wikipedia.org)
  • Researchers found that those who didn't sleep well exhibited more signs of skin aging including fine lines, uneven pigmentation and reduced skin elasticity. (huffingtonpost.com)
  • Age spots and skin tags are harmless, although sometimes skin tags can become irritated. (nih.gov)
  • If your age spots or skin tags bother you, talk to your doctor about having them removed. (nih.gov)
  • Using a broad-spectrum sunscreen that helps protect against two types of the sun's rays (UVA and UVB) may prevent more age spots. (nih.gov)
  • SLPs can assist in differentiating between normal aging and disordered communication or swallowing function. (asha.org)
  • Beth goes to effect see felicia in man where her doctor berates her for being still sexual also to not get the play on time and age to buy viagra that beth is free to her, telling the women to remove her company from the medication vitamin. (topfishinggames.com)
  • For certain industries, such as retail or manufacturing, aging schedules can play a significant part in setting credit standards. (investopedia.com)
  • A new field exploring the relationship between aging and disease. (nih.gov)
  • That's regardless of the number of natural teeth a person has as a middle-aged adult, or whether they have traditional risk factors for cardiovascular disease, such as poor diet or high blood pressure. (reuters.com)
  • Underlying all of these theories is the assumption that aging occurs from the bottom-up, beginning with damage to DNA and proteins and ending with organismal frailty, disability, and disease. (springer.com)