Social Planning: Interactional process combining investigation, discussion, and agreement by a number of people in the preparation and carrying out of a program to ameliorate conditions of need or social pathology in the community. It usually involves the action of a formal political, legal, or recognized voluntary body.Quality Improvement: The attainment or process of attaining a new level of performance or quality.City Planning: Comprehensive planning for the physical development of the city.Ecosystem: A functional system which includes the organisms of a natural community together with their environment. (McGraw Hill Dictionary of Scientific and Technical Terms, 4th ed)Bacteria: One of the three domains of life (the others being Eukarya and ARCHAEA), also called Eubacteria. They are unicellular prokaryotic microorganisms which generally possess rigid cell walls, multiply by cell division, and exhibit three principal forms: round or coccal, rodlike or bacillary, and spiral or spirochetal. Bacteria can be classified by their response to OXYGEN: aerobic, anaerobic, or facultatively anaerobic; by the mode by which they obtain their energy: chemotrophy (via chemical reaction) or PHOTOTROPHY (via light reaction); for chemotrophs by their source of chemical energy: CHEMOLITHOTROPHY (from inorganic compounds) or chemoorganotrophy (from organic compounds); and by their source for CARBON; NITROGEN; etc.; HETEROTROPHY (from organic sources) or AUTOTROPHY (from CARBON DIOXIDE). They can also be classified by whether or not they stain (based on the structure of their CELL WALLS) with CRYSTAL VIOLET dye: gram-negative or gram-positive.Delivery of Health Care: The concept concerned with all aspects of providing and distributing health services to a patient population.Evoked Potentials, Motor: The electrical response evoked in a muscle or motor nerve by electrical or magnetic stimulation. Common methods of stimulation are by transcranial electrical and TRANSCRANIAL MAGNETIC STIMULATION. It is often used for monitoring during neurosurgery.Physics: The study of those aspects of energy and matter in terms of elementary principles and laws. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Diagnostic Techniques, Neurological: Methods and procedures for the diagnosis of diseases of the nervous system, central and peripheral, or demonstration of neurologic function or dysfunction.Climate Change: Any significant change in measures of climate (such as temperature, precipitation, or wind) lasting for an extended period (decades or longer). It may result from natural factors such as changes in the sun's intensity, natural processes within the climate system such as changes in ocean circulation, or human activities.Gravity Sensing: Process whereby a cell, bodily structure, or organism (animal or plant) receives or detects a gravity stimulus. Gravity sensing plays an important role in the directional growth and development of an organism (GRAVITROPISM).United States National Aeronautics and Space Administration: An independent Federal agency established in 1958. It conducts research for the solution of problems of flight within and outside the Earth's atmosphere and develops, constructs, tests, and operates aeronautical and space vehicles. (From U.S. Government Manual, 1993)Time Factors: Elements of limited time intervals, contributing to particular results or situations.Specific Gravity: The ratio of the density of a material to the density of some standard material, such as water or air, at a specified temperature.Esophageal Sphincter, Lower: The physiologic or functional barrier to GASTROESOPHAGEAL REFLUX at the esophagogastric junction. Sphincteric muscles remain tonically contracted during the resting state and form the high-pressure zone separating the lumen of the ESOPHAGUS from that of the STOMACH. (Haubrich et al, Bockus Gastroenterology, 5th ed., pp399, 415)Esophageal Sphincter, Upper: The structure at the pharyngoesophageal junction consisting chiefly of the CRICOPHARYNGEUS MUSCLE. It normally occludes the lumen of the ESOPHAGUS, except during SWALLOWING.Manometry: Measurement of the pressure or tension of liquids or gases with a manometer.Esophagogastric Junction: The area covering the terminal portion of ESOPHAGUS and the beginning of STOMACH at the cardiac orifice.Esophagus: The muscular membranous segment between the PHARYNX and the STOMACH in the UPPER GASTROINTESTINAL TRACT.Esophageal Motility Disorders: Disorders affecting the motor function of the UPPER ESOPHAGEAL SPHINCTER; LOWER ESOPHAGEAL SPHINCTER; the ESOPHAGUS body, or a combination of these parts. The failure of the sphincters to maintain a tonic pressure may result in gastric reflux of food and acid into the esophagus (GASTROESOPHAGEAL REFLUX). Other disorders include hypermotility (spastic disorders) and markedly increased amplitude in contraction (nutcracker esophagus).Peristalsis: A movement, caused by sequential muscle contraction, that pushes the contents of the intestines or other tubular organs in one direction.Longevity: The normal length of time of an organism's life.Intrinsic Factor: A glycoprotein secreted by the cells of the GASTRIC GLANDS that is required for the absorption of VITAMIN B 12 (cyanocobalamin). Deficiency of intrinsic factor leads to VITAMIN B 12 DEFICIENCY and ANEMIA, PERNICIOUS.Cell Aging: The decrease in the cell's ability to proliferate with the passing of time. Each cell is programmed for a certain number of cell divisions and at the end of that time proliferation halts. The cell enters a quiescent state after which it experiences CELL DEATH via the process of APOPTOSIS.Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.Peptide Nucleic Acids: DNA analogs containing neutral amide backbone linkages composed of aminoethyl glycine units instead of the usual phosphodiester linkage of deoxyribose groups. Peptide nucleic acids have high biological stability and higher affinity for complementary DNA or RNA sequences than analogous DNA oligomers.Cobalt Isotopes: Stable cobalt atoms that have the same atomic number as the element cobalt, but differ in atomic weight. Co-59 is a stable cobalt isotope.Anemia, Pernicious: A megaloblastic anemia occurring in children but more commonly in later life, characterized by histamine-fast achlorhydria, in which the laboratory and clinical manifestations are based on malabsorption of vitamin B 12 due to a failure of the gastric mucosa to secrete adequate and potent intrinsic factor. (Dorland, 27th ed)MedlinePlus: NATIONAL LIBRARY OF MEDICINE service for health professionals and consumers. It links extensive information from the National Institutes of Health and other reviewed sources of information on specific diseases and conditions.Gross Domestic Product: Value of all final goods and services produced in a country in one year.National Library of Medicine (U.S.): An agency of the NATIONAL INSTITUTES OF HEALTH concerned with overall planning, promoting, and administering programs pertaining to advancement of medical and related sciences. Major activities of this institute include the collection, dissemination, and exchange of information important to the progress of medicine and health, research in medical informatics and support for medical library development.HIV Infections: Includes the spectrum of human immunodeficiency virus infections that range from asymptomatic seropositivity, thru AIDS-related complex (ARC), to acquired immunodeficiency syndrome (AIDS).Life Expectancy: Based on known statistical data, the number of years which any person of a given age may reasonably expected to live.United StatesPubMed: A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.Drug-Related Side Effects and Adverse Reactions: Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chemically-induced adverse conditions due to toxicity, DRUG INTERACTIONS, and metabolic effects of pharmaceuticals.Drug Evaluation, Preclinical: Preclinical testing of drugs in experimental animals or in vitro for their biological and toxic effects and potential clinical applications.Reinforcement Schedule: A schedule prescribing when the subject is to be reinforced or rewarded in terms of temporal interval in psychological experiments. The schedule may be continuous or intermittent.Drug Administration Schedule: Time schedule for administration of a drug in order to achieve optimum effectiveness and convenience.Tax Exemption: Status not subject to taxation; as the income of a philanthropic organization. Tax-exempt organizations may also qualify to receive tax-deductible donations if they are considered to be nonprofit corporations under Section 501(c)3 of the United States Internal Revenue Code.Income Tax: Tax on the net income of an individual, organization, or business.Immunization Schedule: Schedule giving optimum times usually for primary and/or secondary immunization.Economic Development: Mobilization of human, financial, capital, physical and or natural resources to generate goods and services.Suicide: The act of killing oneself.TokyoSuicide, Attempted: The unsuccessful attempt to kill oneself.Depression: Depressive states usually of moderate intensity in contrast with major depression present in neurotic and psychotic disorders.Tombusvirus: A genus of plant viruses that infects ANGIOSPERMS. Transmission occurs mechanically and through soil, with one species transmitted via a fungal vector. The type species is Tomato bushy stunt virus.Cats: The domestic cat, Felis catus, of the carnivore family FELIDAE, comprising over 30 different breeds. The domestic cat is descended primarily from the wild cat of Africa and extreme southwestern Asia. Though probably present in towns in Palestine as long ago as 7000 years, actual domestication occurred in Egypt about 4000 years ago. (From Walker's Mammals of the World, 6th ed, p801)Genetic Fitness: The capability of an organism to survive and reproduce. The phenotypic expression of the genotype in a particular environment determines how genetically fit an organism will be.Evolution, Molecular: The process of cumulative change at the level of DNA; RNA; and PROTEINS, over successive generations.Quantitative Trait Loci: Genetic loci associated with a QUANTITATIVE TRAIT.Epistasis, Genetic: A form of gene interaction whereby the expression of one gene interferes with or masks the expression of a different gene or genes. Genes whose expression interferes with or masks the effects of other genes are said to be epistatic to the effected genes. Genes whose expression is affected (blocked or masked) are hypostatic to the interfering genes.Selection, Genetic: Differential and non-random reproduction of different genotypes, operating to alter the gene frequencies within a population.Models, Genetic: Theoretical representations that simulate the behavior or activity of genetic processes or phenomena. They include the use of mathematical equations, computers, and other electronic equipment.

The expiry date of man: a synthesis of evolutionary biology and public health. (1/31363)

In industrialised countries, mortality and morbidity are dominated by age related chronic degenerative diseases. The health and health care needs of future populations will be heavily determined by these conditions of old age. Two opposite scenarios of future morbidity exist: morbidity might decrease ("compress"), because life span is limited, and the incidence of disease is postponed. Or morbidity might increase ("expand"), because death is delayed more than disease incidence. Optimality theory in evolutionary biology explains senescence as a by product of an optimised life history. The theory clarifies how senescence is timed by the competing needs for reproduction and survival, and why this leads to a generalised deterioration of many functions at many levels. As death and disease are not independent, future morbidity will depend on duration and severity of the process of senescence, partly determined by health care, palliating the disease severity but increasing the disease duration by postponing death. Even if morbidity might be compressed, health care needs will surely expand.  (+info)

Developmental synaptic changes increase the range of integrative capabilities of an identified excitatory neocortical connection. (2/31363)

Excitatory synaptic transmission between pyramidal cells and fast-spiking (FS) interneurons of layer V of the motor cortex was investigated in acute slices by using paired recordings at 30 degrees C combined with morphological analysis. The presynaptic and postsynaptic properties at these identified central synapses were compared between 3- and 5-week-old rats. At these two postnatal developmental stages, unitary EPSCs were mediated by the activation of AMPA receptors with fast kinetics at a holding potential of -72 mV. The amplitude distribution analysis of the EPSCs indicates that, at both stages, pyramidal-FS connections consisted of multiple functional release sites. The apparent quantal size obtained by decreasing the external calcium ([Ca2+]e) varied from 11 to 29 pA near resting membrane potential. In young rats, pairs of presynaptic action potentials elicited unitary synaptic responses that displayed paired-pulse depression at all tested frequencies. In older animals, inputs from different pyramidal cells onto the same FS interneuron had different paired-pulse response characteristics and, at most of these connections, a switch from depression to facilitation occurred when decreasing the rate of presynaptic stimulation. The balance between facilitation and depression endows pyramidal-FS connections from 5-week-old animals with wide integrative capabilities and confers unique functional properties to each synapse.  (+info)

Low resting potential and postnatal upregulation of NMDA receptors may cause Cajal-Retzius cell death. (3/31363)

Using in situ patch-clamp techniques in rat telencephalic slices, we have followed resting potential (RP) properties and the functional expression of NMDA receptors in neocortical Cajal-Retzius (CR) cells from embryonic day 18 to postnatal day 13, the time around which these cells normally disappear. We find that throughout their lives CR cells have a relatively depolarized RP (approximately -50 mV), which can be made more hyperpolarized (approximately -70 mV) by stimulation of the Na/K pump with intracellular ATP. The NMDA receptors of CR cells are subjected to intense postnatal upregulation, but their similar properties (EC50, Hill number, sensitivity to antagonists, conductance, and kinetics) throughout development suggest that their subunit composition remains relatively homogeneous. The low RP of CR cells is within a range that allows for the relief of NMDA channels from Mg2+ blockade. Our findings are consistent with the hypothesis that CR cells may degenerate and die subsequent to uncontrolled overload of intracellular Ca2+ via NMDA receptor activation by ambient glutamate. In support of this hypothesis we have obtained evidence showing the protection of CR cells via in vivo blockade of NMDA receptors with dizocilpine.  (+info)

Somatic recording of GABAergic autoreceptor current in cerebellar stellate and basket cells. (4/31363)

Patch-clamp recordings were performed from stellate and basket cells in rat cerebellar slices. Under somatic voltage clamp, short depolarizing pulses were applied to elicit action potentials in the axon. After the action potential, a bicuculline- and Cd2+-sensitive current transient was observed. A similar response was obtained when eliciting axonal firing by extracellular stimulation. With an isotonic internal Cl- solution, the peak amplitude of this current varied linearly with the holding potential, yielding an extrapolated reversal potential of -20 to 0 mV. Unlike synaptic or autaptic GABAergic currents obtained in the same preparation, the current transient had a slow rise-time and a low variability between trials. This current was blocked when 10 mM BAPTA was included in the recording solution. In some experiments, the current transient elicited axonal action potentials. The current transient was reliably observed in animals aged 12-15 d, with a mean amplitude of 82 pA at -70 mV, but was small and rare in the age group 29-49 d. Numerical simulations could account for all properties of the current transient by assuming that an action potential activates a distributed GABAergic conductance in the axon. The actual conductance is probably restricted to release sites, with an estimated mean presynaptic current response of 10 pA per site (-70 mV, age 12-15 d). We conclude that in developing rats, stellate and basket cell axons have a high density of GABAergic autoreceptors and that a sizable fraction of the corresponding current can be measured from the soma.  (+info)

Fas/Apo [apoptosis]-1 and associated proteins in the differentiating cerebral cortex: induction of caspase-dependent cell death and activation of NF-kappaB. (5/31363)

The developing cerebral cortex undergoes a period of substantial cell death. The present studies examine the role of the suicide receptor Fas/Apo[apoptosis]-1 in cerebral cortical development. Fas mRNA and protein are transiently expressed in subsets of cells within the developing rat cerebral cortex during the peak period of apoptosis. Fas-immunoreactive cells were localized in close proximity to Fas ligand (FasL)-expressing cells. The Fas-associated signaling protein receptor interacting protein (RIP) was expressed by some Fas-expressing cells, whereas Fas-associated death domain (FADD) was undetectable in the early postnatal cerebral cortex. FLICE-inhibitory protein (FLIP), an inhibitor of Fas activation, was also expressed in the postnatal cerebral cortex. Fas expression was more ubiquitous in embryonic cortical neuroblasts in dissociated culture compared to in situ within the developing brain, suggesting that the environmental milieu partly suppresses Fas expression at this developmental stage. Furthermore, FADD, RIP, and FLIP were also expressed by subsets of dissociated cortical neuroblasts in culture. Fas activation by ligand (FasL) or anti-Fas antibody induced caspase-dependent cell death in primary embryonic cortical neuroblast cultures. The activation of Fas was also accompanied by a rapid downregulation of Fas receptor expression, non-cell cycle-related incorporation of nucleic acids and nuclear translocation of the RelA/p65 subunit of the transcription factor NF-kappaB. Together, these data suggest that adult cortical cell number may be established, in part, by an active process of receptor-mediated cell suicide, initiated in situ by killer (FasL-expressing) cells and that Fas may have functions in addition to suicide in the developing brain.  (+info)

Metrifonate increases neuronal excitability in CA1 pyramidal neurons from both young and aging rabbit hippocampus. (6/31363)

The effects of metrifonate, a second generation cholinesterase inhibitor, were examined on CA1 pyramidal neurons from hippocampal slices of young and aging rabbits using current-clamp, intracellular recording techniques. Bath perfusion of metrifonate (10-200 microM) dose-dependently decreased both postburst afterhyperpolarization (AHP) and spike frequency adaptation (accommodation) in neurons from young and aging rabbits (AHP: p < 0.002, young; p < 0.050, aging; accommodation: p < 0.024, young; p < 0.001, aging). These reductions were mediated by muscarinic cholinergic transmission, because they were blocked by addition of atropine (1 microM) to the perfusate. The effects of chronic metrifonate treatment (12 mg/kg for 3 weeks) on CA1 neurons of aging rabbits were also examined ex vivo. Neurons from aging rabbits chronically treated with metrifonate had significantly reduced spike frequency accommodation, compared with vehicle-treated rabbits. Chronic metrifonate treatment did not result in a desensitization to metrifonate ex vivo, because bath perfusion of metrifonate (50 microM) significantly decreased the AHP and accommodation in neurons from both chronically metrifonate- and vehicle-treated aging rabbits. We propose that the facilitating effect of chronic metrifonate treatment on acquisition of hippocampus-dependent tasks such as trace eyeblink conditioning by aging subjects may be caused by this increased excitability of CA1 pyramidal neurons.  (+info)

Thiamine deficiency is prevalent in a selected group of urban Indonesian elderly people. (7/31363)

This cross-sectional study involved 204 elderly individuals (93 males and 111 females). Subjects were randomly recruited using a list on which all 60-75 y-old-people living in seven sub-villages in Jakarta were included. The usual food intake was estimated using semiquantitative food frequency questionnaires. Hemoglobin, plasma retinol, vitamin B-12, red blood cell folate and the percentage stimulation of erythrocyte transketolase (ETK), as an indicator of thiamine status, were analyzed. Median energy intake was below the assessed requirement. More than 75% of the subjects had iron and thiamine intakes of approximately 2/3 of the recommended daily intake, and 20.2% of the study population had folate intake of approximately 2/3 of the recommended daily intake. Intakes of vitamins A and B-12 were adequate. Biochemical assessments demonstrated that 36.6% of the subjects had low thiamine levels (ETK stimulation > 25%). The elderly men tended to have lower thiamine levels than the elderly women. The overall prevalence of anemia was 28.9%, and the elderly women were affected more than the elderly men. Low biochemical status of vitamins A, B-12 and RBC folate was found in 5.4%, 8.8 % and 2.9% of the subjects, respectively. Dietary intakes of thiamine and folate were associated with ETK stimulation and plasma vitamin B-12 concentration (r = 0.176, P = 0.012 and r = 0.77, P = 0.001), respectively. Results of this study suggest that anemia, thiamine and possibly vitamin B-12 deficiency are prevalent in the elderly living in Indonesia. Clearly, micronutrient supplementation may be beneficial for the Indonesian elderly population living in underprivileged areas.  (+info)

High-linoleate and high-alpha-linolenate diets affect learning ability and natural behavior in SAMR1 mice. (8/31363)

Semipurified diets incorporating either perilla oil [high in alpha-linolenate, 18:3(n-3)] or safflower oil [high in linoleate, 18:2(n-6)] were fed to senescence-resistant SAMR1 mouse dams and their pups. Male offspring at 15 mo were examined using behavioral tests. In the open field test, locomotor activity during a 5-min period was significantly higher in the safflower oil group than in the perilla oil group. Observations of the circadian rhythm (48 h) of spontaneous motor activity indicated that the safflower oil group was more active than the perilla oil group during the first and second dark periods. The total number of responses to positive and negative stimuli was higher in the safflower oil group than in the perilla oil group in the light and dark discrimination learning test, but the correct response ratio was lower in the safflower oil group. The difference in the (n-6)/(n-3) ratios of the diets reflected the proportions of (n-6) polyunsaturated fatty acids, rather than those of (n-3) polyunsaturated fatty acids in the brain total fatty acids, and in the proportions of (n-6) and (n-3) polyunsaturated fatty acids in the total polyunsaturated fatty acids of the brain phospholipids. These results suggest that in SAMR1 mice, the dietary alpha-linolenate/linoleate balance affects the (n-6)/(n-3) ratio of brain phospholipids, and this may modify emotional reactivity and learning ability.  (+info)

TY - JOUR. T1 - Age-associated Differences in Cardiovascular Inflammatory Gene Induction during Endotoxic Stress. AU - Saito, Hiroshi. AU - Papaconstantinou, John. PY - 2001/8/3. Y1 - 2001/8/3. N2 - Upon physiological stress, families of stress response genes are activated as natural defense mechanisms. Here, we show that induction of specific inflammatory genes is significantly dysregulated and altered in the heart of aged (24-26-month-old) versus young (4-month-old) mice experimentally challenged with a bacterial endotoxin, lipopolysaccharide (LPS, 1.5 mg/kg of body mass). Whereas the LPS-mediated induction of cardiac mRNA for tumor necrosis factor α or inducible nitric-oxide synthase showed no age-associated differences, the induction of interleukin-1β (IL-1β) and intracellular adhesion molecule-1 was modestly extended with aging, and the induction of IL-6 was significantly prolonged with aging. This age-associated phenomenon occurred gradually from 4 to 17 months of age and became more ...
Musculoskeletal conditions are a major burden on individuals, healthcare systems, and social care systems throughout the world, with indirect costs having the predominant economic impact. Aging is a major contributing factor to the development and progression of arthritic and musculoskeletal diseases. Indeed, aging and inflammation (often referred to as "inflammaging") are critical risk factors for the development of osteoarthritis (OA), which is one the most common forms of joint disease. The term "chondrosenescence" has recently been introduced to define the age-dependent deterioration of chondrocyte function and how it undermines cartilage function in OA. An important component of chondrosenescence is the age-related deregulation of subcellular signalling pathways in chondrocytes. This mini-review discusses the role of age-related alterations in chondrocyte signaling pathways. In this article we focus our attention on two major areas: age-dependent alterations in transforming growth factor-β ...
Investigations of intracellular signaling revealed reduced phosphorylation of AKT in MDDCs from aging, suggesting decreased activation of PI3kinase signaling pathway. Since PI3K signaling pathway plays a positive regulatory role in phagocytosis and migration, and it also functions as a negative regulator of TLR signaling by inducing activation of p38 MAP kinase, this may explain the aberrant innate immune functioning of DCs from aged subjects. Results further revealed an increased expression of PTEN, a negative regulator of PI3Kinase signaling pathway, in MDDCs from aged subjects. Increased PTEN may thus be responsible for the defect in AKT phosphorylation and therefore, altered innate immune response of DCs from aged humans.. This study is supported in part by a grant AG027512 from NIH and partly by new scholar grant from the Ellison Medical Foundation. ...
Voltage-gated sodium channels (VGSCs) generate the Na+ current (INa) responsible for the cardiac action potential upstroke largely due to the cardiac isoform Nav1.5, but other isoforms are responsible for ˜20% of the upstroke and a component of a sustained sodium current. This sustained component has been attributed with an increasing arrhythmia risk, particularly within the elderly and has been the target of development for new anti-arrhythmic drugs. Our study has investigated the age-associated changes in protein density and localisation of the VGSC alpha-subunits Nav1.5 and Nav1.4 in the rat heart.. Rats at 6, 12 and 28 months of age were sacrificed, their hearts dissected into the regions of left and right ventricle, left and right atria, epicardium and endocardium (n = 5). These regions were analysed by western blot to determine the protein expression of Nav1.5 and Nav1.4 (Alomone, Israel), normalised to the expression of desmin (Dako, UK). Immunocytochemistry of single cardiac myocytes ...
Researchers at Mayo Clinic have shown that eliminating cells that accumulate with age could prevent or delay the onset of age-related disorders and disabilities. The study, performed in mouse models, provides the first evidence ...
Greater social contact and support are associated with better cognitive functioning, whereas greater conflict is associated with lower cognitive functioning.. Diseases either caused by or associated with aging - particularly vascular changes - play a larger role in age-related cognitive changes than is often acknowledged.. This collection of articles, titled "Cognition, Health, and Aging: Integrating Perspectives Across Disciplines," is based on papers presented at a conference held at Penn State University in 2009. Funding for the supplemental issue was provided by the National Institute on Aging through the resources of the Center on Population Health and Aging at Penn State University, and the National Academies Keck Futures Initiative grant, Health and Healthspan in Longitudinal Studies of Aging.. The Journals of Gerontology Series B: Psychological Sciences and Social Sciences is a refereed publication of The Gerontological Society of America (GSA), the nations oldest and largest ...
BACKGROUND. Cancer incidence typically increases with age, but it is not known whether ethnic characteristics influence the age dependence of squamous cell carcinoma of the skin (SCC). OBJECTIVES. (i) To determine the age dependence of SCC in the black African, coloured and white population groups of South Africa (SA); and (ii) to show whether any differences in the rate of change of age dependence could be influenced by diversity in behaviour and lifestyle, especially with regard to the prevalence of HIV infection, rather than by a fundamental variation in cancer biology between the populations. METHODS. Linear regression analysis was applied to the logarithm of the age-specific incidence rates for SCC v. the logarithm of age between 35 and 74 years. The slopes of the regression (age exponent) were compared for each subset of gender, population group and year of diagnosis (between 2000 and 2010). RESULTS. The most notable feature was the low value of the age exponent in both male and female ...
Age-related effects on the default mode network (DMN) connectivity as measured at rest using functional magnetic resonance imaging (fMRI) are now well described. Little is known however about the relationships between these changes and age-related effects on cognition or on the unconstrained thoughts which occur during the resting-state scan, called inner experience. Brain resting-state activity, inner experience, and cognitive ability measurements were obtained in 70 participants aged 19-80 years. The anterior-posterior disruption of DMN activity with age reported in previous studies was recovered here. A significant effect of age was also found on cognitive abilities but not on inner experience. Finally, age-related changes in DMN connectivity were found to correlate with cognitive abilities, and more specifically with autobiographical memory performance. These findings provide new information to fuel the debate on the role of the brain default mode and more specifically on the effect of age-related
The retinal hypoperfusion found in the present study is also in support of the cerebral hypoperfusion, which occurs during normal aging (Table 4).1,5,11,22 Chen et al.1 studied the age-related reduction of CBF during normal aging in a cohort of normal subjects and found that the CBF as an indirect measurement of brain perfusion declined at a rate of −0.38% per year when the entire cortex was examined. Meanwhile, the cortical grey matter volume decreased at a rate of −0.85% per year, which exceeds the reductions in CBF.1 Leenders et al.5 reported that the CBF, cerebral blood volume, and cerebral metabolic rates of oxygen decline at a rate of −0.5% per year during normal aging. The changing rate of the RTP (−0.47% per year), RBF (−0.41% per year), and VVDd (−0.44% per year) found in the present study well matches the CBF change rates reported by Chen et al.1 and Leenders et al.,5 indicating that the RTP, RBF, and VVDd may be good candidates for imaging markers of the age-related ...
Huber, N., Sakai, N., Eismann, T., Shin, T., Kuboki, S., Blanchard, J., Schuster, R., Edwards, M. J., Wong, H. R. and Lentsch, A. B. (2009), Age-related decrease in proteasome expression contributes to defective nuclear factor-κB activation during hepatic ischemia/reperfusion. Hepatology, 49: 1718-1728. doi: 10.1002/hep.22840 ...
Age-related alterations in brain structure and function have been challenging to link to cognition due to potential overlapping influences of multiple neurobiological cascades. We examined multiple brain markers associated with age-related variation in cognition. Clinically normal older humans aged 65-90 from the Harvard Aging Brain Study (N = 186) were characterized on a priori magnetic resonance imaging markers of gray matter thickness and volume, white matter hyperintensities, fractional anisotropy (FA), resting-state functional connectivity, positron emission tomography markers of glucose metabolism and amyloid burden, and cognitive factors of processing speed, executive function, and episodic memory. Partial correlation and mediation analyses estimated age-related variance in cognition shared with individual brain markers and unique to each marker. The largest relationships linked FA and striatum volume to processing speed and executive function, and hippocampal volume to episodic memory. ...
In the past two decades neuroimaging studies have tried to unveil the neural mechanisms behind age-related changes in cognitive strategies and performance. Structural imaging studies have shown that brain volume changes throughout the complete life-span and functional imaging studies have reported age-related differences in brain activation and connectivity. ... read more The aim of this thesis was to provide an overview of studies that report age-related changes in brain activation as measured with functional MRI in a longitudinal design in healthy subjects. We found 16 studies of which 11 reported changes in activity over time. The majority of studies was performed in children. fMRI task used varied between attention, language, memory, working memory and sensory processing tasks. We found increases and decreases in activation in children between 5 and 20 and adults above age 50. A trend of left-hemispheric increases were shown for children around age 8, adults around age 66 and in language ...
Age is the single greatest risk factor in the development of the blinding eye disease AMD where the prevalence of disease significantly increases as individuals enter their sixth decade. 2,3 In spite of this universal observation, other factors that lead to increased disease incidence remain undefined. Increases in damage from environmental stresses, accumulation of damaged proteins and organelles, and loss of function in important biochemical pathways all have been proposed. 3,4,13,52 The immune system is also thought to have a role in disease development 12-14,53 ; however, few studies have addressed how age-related changes in the immune response could be involved. The eye also is an immune privileged organ that can have a strong inhibitory influence on inflammatory and neovascular responses via a number of immunosuppressive mediators. 21 How age-dependent changes in the immune system are influenced by immune privilege and how age might alter the function of immune privilege is currently ...
In this report, we demonstrated that loss of function mutations in Popdc1 and Popdc2 genes in mice are associated with stress-induced SND, resulting in chronotropic incompetence and long sinus pauses. The Popdc genes displayed overlapping myocardial expression patterns and similar biochemical properties, and the cardiac phenotypes of the null mutants were nearly identical. Our data suggest that Popdc proteins represent a novel class of cAMP binding proteins that interact with TREK-1 channels and may be involved in channel trafficking. Age-dependent decline in cardiac pacemaking in Popdc null mutants. Both mouse mutants developed SND at advanced age. Assuming that Popdc genes act in the same pathway, loss of a single gene might not have a significant impact on function in the young, since both Popdc genes might be able to substitute for each other. Obviously, the compensation became less efficient when the null mutants aged, possibly due to an age-dependent decline of Popdc expression. ...
The diversity of the human TCR repertoire in aging has been studied by examining the profiles of complementarity-determining region 3 (CDR3) sizes expressed by the BV families. The TCRBV CDR3 profile, which shows size heterogeneity in young adult humans, is significantly restricted in aged humans. Clonal T cell expansions were identified using a PCR-based approach, in one or more BV families from all 14 healthy persons over the age of 65 that we studied. CD4+ T cell expansions were identified in 8 of 11 donors and CD8+ T cell expansions in 7 of 10 donors. These clonal expansions were stable during a 2-year period. Interestingly, more than half of the aged persons had clonal expansions within the BV3, -14, -16, and -23 families. Although there was no homology among the eight CDR3 sequences identified in clonal T cells from 8 aged persons, selective pressure on the expanded T cell clones was suggested by the fact that the BV families used by the T cell clones were not proportional to the number of ...
Immune aging may underlie various aging-related disorders, including diminished resistance to infection, chronic inflammatory disorders, and autoimmunity. PD-1+ and CD153+ CD44high CD4+ T cells with features of cellular senescence, termed senescence-associated T (SA-T) cells, increasingly accumulate with age and may play a role in the immune aging phenotype. In this article, we demonstrate that, compared with young mice, the aged mouse environment is highly permissive for spontaneous proliferation of transferred naive CD4+ T cells, and it drives their transition to PD-1+ and CD153+ CD44high CD4+ T cells after extensive cell divisions. CD4+ T cells with essentially the same features as SA-T cells in aged mice are also generated from naive CD4+ T cells after extensive cell divisions under severe T-lymphopenic conditions by gamma irradiation or in developmental T cell defect, often in association with spontaneous germinal centers, as seen in aged mice. The increase in SA-T cells is significantly enhanced
Geoffroy CG, Hilton BJ, Tetzlaff W, Zheng B How aging impacts axon regeneration after CNS injury is not known. We assessed the impact of age on axon regene …
TY - JOUR. T1 - Analysis of the age-related refractoriness of T-lymphocyte reactivity in humans. AU - Bátory, Gabriella. AU - Ónody, Clara. AU - Petrányi, G. Gy. PY - 1981/4. Y1 - 1981/4. N2 - Aged individuals could be divided into two groups according to their T-lymphocyte transformation values. The relationship between the PHA (phytohemagglutinin) stimulation indices and spontaneous thymidine incorporation; the PHA dose-response type distribution and the relative number of resting T lymphocytes was similar to the control group in aged subjects of seemingly intact T lymphocyte transformation values. However, their B cell compartment was found to be reduced. On the other hand, the ratio between the stimulation indices and spontaneous thymidine incorporation values of aged subjects of impaired T lymphocyte reactivity deviated from that of the control group. This group had an increased frequency of subjects giving maximal transformation values at relatively high PHA doses (hyposensitives) at ...
Umbilical cord blood from human newborns, and in particular a single protein contained in it, boosted old mices brain function and cognitive performance
The present study tested whether aging alters endotoxin-induced myocardial dysfunction in a sublethal model of endotoxemia in rats. The main findings were the following: 12 hours after LPS injection (0.5 mg/kg), a marked reduction in myocardial contractility was observed in the isolated perfused senescent heart; in contrast with septic cardiac dysfunction in young rats, myofilament Ca2+ sensitivity of left ventricular skinned fibers was not reduced in senescent rats; and NO production, oxidative stress, and antioxidant enzymes activities were not different between young adult and senescent LPS groups. Thus, despite similar alterations in potential mediators, cellular mechanisms responsible for this contractile dysfunction are different between young adult and senescent rats. More specifically, myofilament Ca2+ responsiveness remains unaltered in the senescent heart. This may have clinical implications for management of elderly septic patients.. Nonlethal models of endotoxemia have allowed ...
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First, we found that the level of soluble HS is positively correlated with age in vitreous samples from idiopathic maculopathies. We then showed that soluble HS levels in aqueous humor were lower in younger diabetic subjects with retinal NVs than in older diabetic subjects without retinal NVs or in nondiabetic subjects with cataract; the difference was no longer significant after controlling for the ages in these groups. The lack of correlation between severity of retinopathy and HS levels suggests that reduced HS levels in the aqueous humor in younger PDR patients could be explained at least in part by age and not by the severity of retinopathy. While the observation appears to contradict the reported correlation between reduced HS levels in the kidney and the diabetes mellitus [16-18], our study does not exclude the possibility of a less significant contribution of diabetes mellitus to ocular levels of HS. Analysis of the intraocular fluid from nondiabetic controls age-matched for PDR and a ...
Various age-related changes in the biomechanics and topography of different ocular components have been reported in the literature. Albon et al. (2000) observed a decrease in both the mechanical compliance and resilience of the human lamina cribrosa with age, and similar observations were made by Krag et al. (1997) in the lens capsule. Strong association was found between the age-related alterations in the optic nerve head and its increased susceptibility to glaucomatous damage (Burgoyne & Downs 2008). The asphericity of both the anterior and posterior corneal surfaces was reported to undergo significant changes with age, leading to a more spherical topography (Lam & Douthwaite 2002) and peripheral thinning (Dubbelman et al. 2006). Stiffening and increased tensile strength of the sclera were also found to be strongly associated with age (Avetisov et al. 1983; Schultz et al. 2008). Where an explanation was provided for these changes, it was the age-related increase in the intermolecular and ...
Evidence for age-dependent impairment of ovalbumin heterogeneous nuclear RNA (HnRNA) processing in hen oviduct.: The expression of the ovalbumin gene in hen ovi
Coenzyme Q10 supplementation reverses age-related impairments in spatial learning and lowers protein oxidation - Age (Dordr). 2013 Oct;35(5):1821-34 - the current study assessed the effect of CoQ intake in older mice for which cognitive and psychomotor impairments were already evident. Separate groups of young (3.5 months) and relatively old mice (17.5 months) were fed a control diet or a diet supplemented with low (0.72 mg/g) or high (2.81 mg/g) concentrations of CoQ for 15 weeks. After 6 weeks, the mice were given tests for spatial learning (Morris water maze), spontaneous locomotor activity, motor coordination, and startle reflex. Age-related impairments in cognitive and psychomotor functions were evident in the 17.5-month-old mice fed the control diet, and the low-CoQ diet failed to affect any aspect of the impaired performance. However, in the Morris water maze test, old mice on the high-CoQ diet swam to the safe platform with greater efficiency than the mice on the control diet. The old ...
This data collection contains data gathered in a longitudinal study of a sample of men aged 65 to 92 who were in good health during the first wave of the study in 1957. The chief aim of the study was to focus on the nature of the normal aging process in individuals of advanced age. The 47 study participants had not suffered from accidents, illnesses, severe emotional or personality problems, or environmental difficulties that might have led to premature aging, but 20 participants showed evidence of asymptomatic subclinical disease. This group represented the typical or average healthy aged individual with minimal degrees of physical pathology. Five years later, in 1962, a follow-up study was conducted with 29 of the 39 men still alive. The second follow-up, done in 1968, involved 19 of the surviving 23 men. The data are arranged in files by year: 1957, 1962, and 1968. Included are psychiatric data and medical evaluative data as well as various psychological and medical test scores (e.g., ...
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The effects of the co-agonist of the N-methyl-d-aspartate receptor (NMDAr) d-serine on glutamatergic neurotransmission and synaptic potentiation were studied in the CA1 hippocampal field of young (3-5 months old) and aged (25-27 months old) Sprague-Dawley rats using ex vivo extracellular electrophysiological recording techniques. Exogenous d-serine depressed fast neurotransmission mediated by the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid/kainate subtype of glutamate receptors in young but not in aged rats by acting on inhibitory glycinergic interneurons. In contrast, d-serine dose-dependently enhanced NMDAr-mediated synaptic responses in both groups of animals, but with a larger magnitude in aged rats, thus preventing the age-related decrease in NMDAr activation. d-serine also increased the magnitude of long-term potentiation in aged but not in young rats. Finally, d-serine levels were dramatically reduced in hippocampal tissues of aged rats. Taken together, these results indicate a ...
Background: Acute lung injury (ALI) is a significant source of morbidity and mortality in critically ill patients. Age is a major determinant of clinical outcome in ALI. The increased ALI-associated mortality in the older population suggests that there are age-dependent alterations in the responses to pulmonary challenge. The objective of this observational study was to evaluate age-dependent differences in the acute (within 6 hours) immunological and physiological responses of the heart and lung, to pulmonary challenge, that could result in increased severity. Methods: Male C57Bl/6 mice (young: 2-3 months, old: 18-20 months) were challenged intratracheally with cell wall components from Gram-positive bacteria (lipoteichoic acid and peptidoglycan). After 6 hours, both biochemical and physiological consequences of the challenge were assessed. Alveolar infiltration of inflammatory cells and protein, airspace and blood cytokines, cardiac function and myocardial proteasome activity were determined. Results:
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PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Chair: Juulia Jylhävä. Markers of biological age have recently proven to be strong mortality predictors independent of other risk factors. As individuals with the same chronological age can vary substantially for their biological age it has become a pressing issue to find the determinants for biological age. This symposium presents findings on the genetic and environmental influences to the following markers of biological age: self-rated health, the frailty index, the epigenetic clock and telomere length. Using unique longitudinal twin cohorts with wide age ranges, we are also able to assess the changes in the contributing sources variation - i.e., genetics and shared and unique environments. The first paper demonstrates how the heritability of self-rated health is influenced by financial strain. The second paper examines if the polygenic risk scores for well-being are predictive of objective (i.e. frailty and multi-morbidity) and subjective indicators of age-related health (e.g. ...
Recent statistics indicate that the human population is ageing rapidly. Healthy, but also diseased, elderly people are increasing. This trend is particularly evident in Western countries, where healthier living conditions and better cures are available. To understand the process leading to age-associated alterations is, therefore, of the highest relevance for the development of new treatments for age-associated diseases, such as cancer, diabetes, Alzheimer and cardiovascular accidents. Mechanistically, it is well accepted that the accumulation of intracellular damage determined by reactive oxygen species (ROS) might orchestrate the progressive loss of control over biological homeostasis and the functional impairment typical of aged tissues. Here, we review how epigenetics takes part in the control of stress stimuli and the mechanisms of ageing physiology and physiopathology. Alteration of epigenetic enzyme activity, histone modifications and DNA-methylation is, in fact, typically associated with the
Recent statistics indicate that the human population is ageing rapidly. Healthy, but also diseased, elderly people are increasing. This trend is particularly evident in Western countries, where healthier living conditions and better cures are available. To understand the process leading to age-associated alterations is, therefore, of the highest relevance for the development of new treatments for age-associated diseases, such as cancer, diabetes, Alzheimer and cardiovascular accidents. Mechanistically, it is well accepted that the accumulation of intracellular damage determined by reactive oxygen species (ROS) might orchestrate the progressive loss of control over biological homeostasis and the functional impairment typical of aged tissues. Here, we review how epigenetics takes part in the control of stress stimuli and the mechanisms of ageing physiology and physiopathology. Alteration of epigenetic enzyme activity, histone modifications and DNA-methylation is, in fact, typically associated with the
Aged rats (22 to 24 months) and young control rats (3 months) were tested in a battery of behavioral tests which included tests of learning, place navigation, sensorimotor integration, motor coordination, activity, and exploration. Following testing all animals were analyzed in an unanesthetized state for their local glucose utilization. Significant differences in glucose utilization were found between the aged and young groups on some behaviors and in some brain regions. There was considerable variability in the aged group in both their behavioral performance and their glucose utilization scores; thus, attempts were made to determine whether the variability in the degree of impairment within any particular behavioral test was correlated to the regional glucose utilization scores in any of the 45 brain regions analyzed. In two of the behavioral tests employed (i.e., one for learning and one for place navigation), the decline in performance correlated significantly with the decrement in regional ...
Matsuzawa, T and Cinader, B, "Polymorphism of age-dependent changes in the production of a thf helper factor." (1982). Subject Strain Bibliography 1982. 2609 ...
Age-dependent changes in the exocytotic efficacy in Kir6.2 ablated mouse pancreatic β-cells. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
Reduced volume, or atrophy, in parts of the brain known as the amygdala and hippocampus may predict which cognitively healthy elderly people will develop dementia over a six-year period, according to a study.
Impaired energy production in older neurons may help explain why human brains are so vulnerable to age-related diseases, according to a new study at Salk Institute in California.. The scientists used a new strategy to discover that cells from older people had dysfunctional mitochondria - the power stations of cells - and lower energy production.. Mitochondria are responsible for converting our food into chemical energy our cells can use. Defects in mitochondrial genes can lead to disease, but researchers also know that mitochondria become less efficient with age and can drive age-related disorders, such as Alzheimers and Parkinsons.. Studying the impact of aging on mitochondria could help researchers gain a better understanding of the known link between mitochondrial dysfunction and age-related brain diseases.. The new findings are published in the journal Cell Reports.. "Most other methods use chemical stresses on cells to simulate aging," said senior author Dr. Rusty Gage, a professor in ...
Many detailed questions were formulated in order to provide a framework for discussing the crucial gaps in knowledge concerning CMV and immunosenescence. These included asking whether immunosenescence starts at the level of the hematopoietic stem cell (HSC); the role of the thymus? Which biomarkers are best? What impact does CMV have on the HSC microenvironment, thymus? Is there no age-associated decrease of CD8 naïve cells in CMV-negative people? Is the decrease in naïve cells in CMV+ people limited to CD8, and not CD4, cells? Is the decrease of naïve cells associated with any clinical outcome? Are T-regs altered with age and what is the effect of CMV thereon? Does CMV affect B cells (part of the IRP)? Is there a contribution of innate immunity to the IRP? What is the impact of CMV on cells bridging innate and adaptive immunity (Th17, Tγδ, NK, NKT, DC)? What is the relevance of telomere length measurements? Relevance of humoural factors, cytokines, such as type I IFN blocking telomerase; ...
Eosinophils surrounded by red blood cells (stock image). Credit: © Kateryna_Kon / Frailty and immune decline are two main features of old age.
The results of the present experiments establish that angiogenesis is impaired as a function of age. The reduced capability for collateral vessel development in response to ischemia was confirmed in 2 different animal models. The ultimate hindlimb BPR achieved at 40 days after surgery was significantly less in old than in young NZW rabbits. In old mice, perfusion of the ischemic hindlimb, reflected by the Doppler flow ratio, was significantly reduced compared with young mice; this difference was apparent as soon as 7 days after surgery and persisted throughout the duration (28 days) of the study. Likewise, the number of blood vessels that were angiographically visible in rabbits and the number of capillaries per unit area identified histologically in mice and rabbits were both significantly reduced in old versus young animals. The latter finding is consistent with the observation that myocardial angiogenesis related to left ventricular hypertrophy is attenuated in an age-dependent manner.20 The ...
Our results demonstrate that overexpression of mCAT protects mice from cardiac aging, providing direct evidence for the role of mitochondrial ROS in the aging of this vital organ. Several lines of evidence support this conclusion. In WT mice from the longevity cohort, we found age-dependent LV hypertrophy and a decline in cardiac performance (especially diastolic function), concomitant with the accumulation of oxidized mitochondrial proteins, mtDNA mutations, increased ventricular fibrosis, cardiomyocyte hypertrophy, a decline in SERCA2 protein, and activation of the calcineurin-NFAT pathway in the aged heart. These age-related alterations took place in the absence of significant cardiovascular risks such as diabetes, hypertension, or hypercholesterolemia, suggesting that these findings are primary changes of cardiac aging rather than secondary to other diseases. mCAT littermates were partially protected from all of the above age-related cardiac alterations, suggesting that these aging changes ...
From In Search of Enlightenment: "On this WHO website the fact that chronic disease killed 9 million people under the age of 60 last year is highlighted. This is of course a human tragedy that should be mitigated. That is twice the number of deaths estimated to be caused by all injuries in the world. However, if you do the math on this data, that means that 27 million people worldwide died from chronic disease that is caused (primarily, though the story is complex) by aging. This is 75% of the worlds chronic disease burden. Aging is the leading cause of disease and death in the world today. ... Not only that, it is the largest health threat today. In just a decade of the chronic diseases of aging the worlds population will suffer more more disease and death than in any decade of the worst wars and conflicts in human history. Everyone agrees that conflict and war is bad for us, and that our governments should strive to ensure there is lasting peace between nations. And yet few people today ...
Show moreOBJECTIVE: With aging, skin is likely to become less hydrated, thereby increasing its resistance to electrical current. This, rather than sensorial/perceptual differences per se, may be the primary cause of differences between younger and older adults in somatosensorial perception in response to electrical stimuli. METHODS: To assess whether aging alters the perception of electrical stimulation, we compared the perceived intensity of electrical stimuli in younger and older subjects, considering both setpoint intensities and the actual intensities of the current passing through subjects skin. This resulted in reliable information about electrical somatosensory perception in both groups at equivalent received amounts of current. Somatosensory evoked potentials (SEPs) enabled the objective evaluation of somatosensitivity in both groups. RESULTS: At equivalent received intensities, the mean ratings were significantly lower in older than in younger subjects. SEPs confirmed these results, ...
Physical activity (PA) is known to improve health and decrease the risk of developing cardiovascular disease (CVD) in a variety of populations. However, less is known regarding the influence of habitual or daily PA in preventing cardiovascular events among older adults. In particular, data are lacking regarding the influence of daily PA on cardiovascular risk among older adults with mobility limitations that restrict the ability to engage in PA. Although associations between the quantity of PA and cardiovascular risk factors have been reported in older adults, few have made these connections using objective measurements of PA. To date, most studies have relied on self-reported measures of PA, which commonly misclassify the volume and/or intensity of PA. Although PA has been shown to have an inverse relationship with cardiovascular risk factors and morbidity, it is unknown whether participation in activity reduces cardiovascular incidence in populations of older adults displaying habitually low ...
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Oxidative stress has been implicated in playing a pathogenic role in many disease processes, especially in age-related disorders. It has been hypothesized that antioxidative agents such as vitamins and minerals, which are capable of scavenging free radicals, may reduce oxidative stress and may, in turn, be beneficial for patients with age-related disorders. Based on this hypothesis, several different combinations of vitamins have been introduced, all targeting at reducing oxidative stress. However, the in-vivo determination of the antioxidative properties of a certain drug or vitamin combination are hard to determine. In the current study, the researchers propose to investigate the effect of VITAMAC®, a combination of vitamins and minerals, in a systemic in-vivo inflammation model.. In the present study, the infusion of LPS, which is a cell wall component of Gram-negative bacteria and a major mediator in the pathogenesis of septic shock, will be used as a standardized experimental model of ...
Two groups of investigators in Canada, from the University of British Columbia, Vancouver and the University of Victoria, recently published the results of their study on the age-associated decline in memory in the journal PLoS ONE. The article, "Glutathione Restores the Mechanism of Synaptic Plasticity in Aged Mice to That of the Adult," details the teams research and conclusions on the connection between maintaining memory and a healthy redox balance in brain cells.. Previous research associated a reduced redox potential (a more oxidized cellular environment) with aging and demonstrated a correlation, in the hippocampus (specifically the CA1 region), to a lower level of the major antioxidant, glutathione (GSH). The British Columbian investigators hypothesized not only that age-associated memory impairment is a consequence of this condition, but also that GSH is key to one of two related hippocampal mechanisms.. The two mechanisms are involved in calcium ion transport and necessary for memory ...
University of Arizona Aging is associated with specific impairments of learning and memory, some of which are similar to those caused by damage to temporal or frontal lobe structures. For example, healthy older humans, monkeys and rats all show poorer spatial, recognition and working memory, than do their younger counterparts. Rats and monkeys do not develop age-related pathology such as Alzheimers or Parkinsons diseases, which makes them good models for assessing functional alterations associated with normal aging in humans. While many cellular properties of medial temporal lobe cells appear to be intact in aging animals, age-related impairments in synaptic function, plasticity and gene expression have been observed. Because information is represented by activity patterns across large populations of neurons, an understanding of the neural basis of cognitive changes in aging requires the examination of the dynamics of behaviorally-driven neural networks. Ensemble recording experiments are ...
Middle Ages[edit]. A manuscript of Al-Risalah al-Dhahabiah by Ali al-Ridha, the eighth Imam of Shia Muslims. The text says: " ... After the fall of the Western Roman Empire and the onset of the Early Middle Ages, the Greek tradition of medicine went into ... During the Middle Ages, the Catholic Church established universities which revived the study of sciences - drawing on the ... In China, archaeological evidence of medicine in Chinese dates back to the Bronze Age Shang Dynasty, based on seeds for ...
1967 Age Discrimination in Employment Act[edit]. The Age Discrimination in Employment Act (ADEA) of 1967 prohibited employment ... Some older workers were being denied health benefits based on their age and denied training opportunities prior to the passage ... Children under eighteen cannot do certain dangerous jobs, and children under the age of sixteen cannot work during school hours ... to allow an employer to pay less than the minimum wage to individuals whose earning or productive capacity is impaired by age, ...
Current records by age-group[edit]. Age group. Male record. Distance (KM). Female record [86]. Distance (KM) ... Age 30-34 Date Rider Age Velodrome Distance (km) Supported by Equipment Notes ... Age 35-39 Date Rider Age Velodrome Distance (km) Supported by Equipment Notes ... Age 40-44 Date Rider Age Velodrome Distance (km) Supported by Equipment Notes ...
As age increases, age-related observational learning motor skills may decrease in athletes and golfers.[14] Younger and skilled ... Age difference[edit]. Albert Bandura stressed that developing children learn from different social models, meaning that no two ... For example, girls aged 11 to 14 performed better on a motor performance task when they thought it was demonstrated by a high- ... Children aged 6 to 8 in an indigenous heritage community in Guadalajara, Mexico participated in hard work, such as cooking or ...
Chemotherapy and aging[edit]. In aged and chemotherapy treated females, oocytes and follicles are depleted by apoptosis ( ... DNA damage-induced oocyte apoptosis depends on the efficiency of the DNA repair machinery that in turn declines with age. ... Survival of oocytes following chemotherapy or aging can be enhanced by increased expression of Rad51.[35] The Rad51-induced ... "Enhancing survival of mouse oocytes following chemotherapy or aging by targeting Bax and Rad51". PLoS ONE. 5 (2): e9204. doi ...
The smell of aged pu'erh may vary, with an "aged" but not "stuffy" odor. The taste of aged raw pu'erh or ripe pu'erh should be ... Because of its ability to age without losing "quality", well aged good pu'er gains value over time in the same way that aged ... Bǐngchá and zhuancha thus age more quickly than golden melon, tuocha, or jincha. Larger bingcha age slower than smaller ' ... Aging and storage[edit]. Pu'er teas of all varieties, shapes, and cultivation can be aged to improve their flavor, but the ...
Aging[edit]. BDNF levels appear to be highly regulated throughout the lifetime both in the early developmental stages and in ... Although BDNF is needed in the developmental stages, BDNF levels have been shown to decrease in tissues with aging.[90] Studies ... Tapia-Arancibia L, Aliaga E, Silhol M, Arancibia S (November 2008). "New insights into brain BDNF function in normal aging and ... it does suggest there is a relationship that might explain some of the cognitive decline that occurs during aging. ...
Age of onset[edit]. ALS can also be classified based on the age of onset. While the peak age of onset is 58 to 63 for sporadic ... The disease can affect people of any age, but usually starts around the age of 60 and in inherited cases around the age of 50.[ ... the lowest prevalence was in the 18-39 age group, while the highest prevalence was in the 70-79 age group.[18] Sporadic ALS ... "Aging and Disease. 4 (5): 295-310. doi:10.14336/AD.2013.0400295. PMC 3794725. PMID 24124634.. ...
Developmental age[edit]. Fehr, Bernhard, and Rockenbach (2008), in a study conducted on children, found that boys displayed in- ... Thus males tended to show in-group biases from a younger age than females, as was evident in the experiment.[29] ... group favouritism from ages 3-8, whereas girls did not display such tendencies.[29] The experiment involved usage of an "envy ...
Insulation aging[edit]. R-values of products may deteriorate over time. For instance the compaction of loose fill cellulose ... However, the LTTR effectively provides only an eight-year aged R-value, short in the scale of a building that may have a ... There are other foams which do not change significantly with aging because they are blown with water or are open-cell and ... Foil-faced polyisocyanurate rigid panel (pentane expanded) aged 5-10 years 0.97. R-5.5. 38 ...
a b Hegermann, Harald (2008) "The Diaspora in the Hellenistic Age." In: The Cambridge History of Judaism, Vol. 2. Eds.: Davies ... Kleiner, Fred (2010). Gardner's Art Through the Ages: A Global History, Enhanced, Volume I: 1. Wadsworth Publishing. p. 262. ... Middle Ages. Ashkenazi Jews. Ashkenazi Jews is a general category of Jewish populations who immigrated to what is now Germany ... Antonia Tripolitis (2002). Religions of the Hellenistic-Roman Age. Wm. B. Eerdmans Publishing. pp. 61-62. ISBN 9780802849137.. ...
Middle Ages[edit]. The oldest mention of the city appears in a cartulary, Bayonne's Golden book, from 1186, where it is named ... From the Middle Ages and Early modern period a watchtower has looked down over the sea at Biarritz, from "La Humade", waiting ... Two population centers are attested in the Middle Ages. On the one hand, the église Saint-Martin was active in the ...
Tuohimaa P (March 2009). "Vitamin D and aging". The Journal of Steroid Biochemistry and Molecular Biology. 114 (1-2): 78-84. ... Premature aging[edit]. Complex regulatory mechanisms control metabolism. Recent epidemiologic evidence suggests that there is a ... Keisala T, Minasyan A, Lou YR, Zou J, Kalueff AV, Pyykkö I, Tuohimaa P (July 2009). "Premature aging in vitamin D receptor ... Tuohimaa P, Keisala T, Minasyan A, Cachat J, Kalueff A (December 2009). "Vitamin D, nervous system and aging". ...
Old trees with estimated ages[edit]. Note: The ages of the trees in this list are speculative and probably unreliable. ... Individual trees with verified ages[edit]. Name. Age. (years). Species. Location. Country. Notes ... There are three tables of trees, which are listed by age and species. The first table includes trees for which a minimum age ... Age. (years). Species. Location. Country. Notes ?[nb 2]. 5,069. Great Basin bristlecone pine. Pinus longaeva. White Mountains ( ...
Imbrie, John (1979). Ice ages: solving the mystery. Cambridge MA: Harvard University Press. ISBN 978-0-674-44075-3. .. ... There has been a cycle of ice ages for the past 2.2-2.1 million years (starting before the Quaternary in the late Neogene ... Ice core data for the past 800,000 years (x-axis values represent "age before 1950", so today's date is on the left side of the ... It has been observed that ice ages deepen by progressive steps, but the recovery to interglacial conditions occurs in one big ...
Golden age. See also: History of general relativity. In 1958, David Finkelstein identified the Schwarzschild surface as an ... These results came at the beginning of the golden age of general relativity, which was marked by general relativity and black ...
Between ages 10 and 20 the comparable figures are 10.2 and 12.1; and from ages 20 to 44, 25.9 as against 34.3. The percentage ... Clarkson, Tim (2014). Strathclyde and the Anglo-Saxons in the Viking Age. Edinburgh: John Donald. ISBN 978 1 906566 78 4. .. ... The antiquary W G Collingwood, commenting in 1925 about finds in the area, wrote that they showed "Stone Age man was fairly at ... Keswick's recorded history starts in the Middle Ages. The area was conquered by the Anglo-Saxon Kingdom of Northumbria in the ...
The age when CP is diagnosed is important, but medical professionals disagree over the best age to make the diagnosis.[66] The ... Aging[edit]. Children with CP may not successfully transition into using adult services because they are not referred to one ... Zaffuto-Sforza, Celeste D. (February 2005). "Aging with cerebral palsy". Physical Medicine and Rehabilitation Clinics of North ... Prevalence of cerebral palsy is best calculated around the school entry age of about 6 years, the prevalence in the U.S. is ...
Flags of Portugal during the Middle Ages[edit]. Five different flags were used during the period from 1139 until 1415. As seen ... In 1171 Afonso concluded a seven years truce with the Moors; weakened by his wound and by old age, he could no longer take the ... In 1122 Afonso became fourteen, the adult age in the 12th century. He made himself a knight on his own account in Zamora ... In 1184, in spite of his great age, King Afonso of Portugal still had sufficient energy to relieve his son Sancho, who was ...
In the Middle Ages, these included the Abbasids of Baghdad, and the Fatimids, Ayyubids and Mamluks of Egypt.[63] ... Middle Ages[edit]. Despite its spiritual importance, in political terms Arabia soon became a peripheral region of the Islamic ... Age of the Caliphs Expansion under Muhammad, 622-632/A.H. 1-11 ... 3.3 Middle Ages. *3.4 Modern history *3.4.1 Late Ottoman rule ... the stone tools from the Middle Paleolithic age along with fossils of other animals discovered at Ti's al Ghadah, in ...
For children ages 1-17 years the PRIs increase with age from 120 to 270 μg/day. These values differ somewhat from the U.S. RDAs ... Age Infants (AI) Infants (UL) Children and adults (RDA) Children and adults (UL) Pregnant women (RDA) Pregnant women (UL) ... Age-related macular degeneration[edit]. A sub study of the Women's Antioxidant and Folic Acid Cardiovascular Study published in ... For women and men over age 18 the PRI is set at 330 μg/day. PRI for pregnancy is 600 μg/day, for lactation 500 μg/day. ...
Swank, J.H. (1892). History of the Manufacture of Iron in All Ages, and Particularly in the United States From Colonial Times ... Age[edit]. On the geological timescale, the Marcellus occurs in the Middle Devonian epoch, of the Devonian period, in the ... Relative age dating of the Marcellus places its formation in the Cazenovia subdivision of the Givetian faunal stage, or 391.9 ... Stratigraphically, the Marcellus is the lowest unit of the Devonian age Hamilton Group, and is divided into several sub-units. ...
Williams, Alan (2003). The Knight and the Blast Furnace: A History of the Metallurgy of Armour in the Middle Ages & the Early ... Initially constructed from leather and brass, and then bronze and iron during the Bronze and Iron Ages, they soon came to be ... In European history, well-known armor types include the mail hauberk of the early medieval age, and the full steel plate ... In antiquity and in the Middle Ages, shields were used by foot soldiers and mounted soldiers. Even after the invention of ...
Age[edit]. Jeanette M. Bruce and William C. Sanderson, in their book Specific Phobias, concluded that the age of onset for ... minor patients (those under the age of 18) have symptoms lasting for at least six months ... Thirty-seven women ages 18 to 21 were first screened into two groups: fearful of dogs and non-fearful of dogs.[13] Next, each ... This study utilized 20 female patients suffering from various specific phobias and ranging in age from 16 to 44.[25] Patients ...
The voting age for all federal elections was lowered from 21 to 18 in 1973.[15] The states had lowered the voting age to 18 by ... Voting age[edit]. Initially, voting in colonial elections was based on a property requirement. The Australian Constitution ... The Act declared that all British subjects over the age of 21 years who had been living in Australia for at least 6 months were ... The property requirement was replaced for the lower houses of colonial Parliaments with a voting age of 21 years for men only, ...
All races and origins1, Male, by Age Group. Leading Causes of Death, 2017, All races and origins, male, by Age Group. Age Group ... 3Figures for age not stated are included in "all ages" but not distributed among age groups. ... All races and origins1, Male, All ages2. Leading Causes of Death, United States, males, 2017, all races and origins, all ages. ... All ages. 1. Unintentional injuries. 33.8%. Unintentional injuries. 38.9%. Cancer. 24.7%. Cancer. 27.5%. Heart disease. 30.1%. ...
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Now heres another good reason to get enough sleep: sleep deprivation also could cause your skin to age faster, according to a ... The amount of sleep one needs depends on a persons age. Most experts recommend that adults get between seven and eight hours ... The study involved 60 pre-menopausal women between the ages of 30 and 49, with half of them falling into the poor quality sleep ... Sleep deprived women show signs of premature skin aging and a decrease in their skins ability to recover after sun exposure," ...
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Ageless Aging brain American Academy of Anti-Aging Medicine Biogerontology Biological immortality DNA repair DNA damage theory ... Life extension strategies often study the causes of aging and try to oppose those causes in order to slow aging. Rejuvenation ... de Grey, Aubrey; Rae, Michael (September 2007). Ending Aging: The Rejuvenation Breakthroughs that Could Reverse Human Aging in ... was applied as a robust method of decelerating aging and the development of age-related diseases. The biomedical gerontologist ...
... from the mitotic age of cells to the organismal-wide aging of tissues and organs. The appearance of cancer is only one clinical ... Aging is defined at many levels, from the mitotic age of cells to the organismal-wide aging of tissues and organs. The ... Aging. During an organisms life span almost every aspect of its phenotype will undergo modification. The complexity of aging ... Age-associated epithelial cancers, such as breast cancer, colon cancer, and prostate cancer, however, contribute significantly ...
Menopause accelerates biological aging Morgan E. Levine, Ake T. Lu, Brian H. Chen, Dena G. Hernandez, Andrew B. Singleton, ... Hhip haploinsufficiency sensitizes mice to age-related emphysema Taotao Lao, Zhiqiang Jiang, Jeong Yun, Weiliang Qiu, Feng Guo ... Chromatin-modifying genetic interventions suppress age-associated transposable element activation and extend life span in ...
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The level of investigative activity into the mechanisms of aging at the cellular and molecular level has increased dramatically ... Effects of age on cell division capacity. In: Danon D, Shock NW, Marois M, eds. Aging: A Challenge to Science and Society. New ... Aging and the immune system. In: Warner HR, Butler RN, Sprott RL, et al, eds. Modern Biological Theories of Aging. New York, NY ... Theories of aging: a perspective. In: Warner HL, Butler RN, Sprott RL, et al, eds. Modern Biological Theories of Aging. New ...
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Welcome to the Aging Issue. A growing senior wave is challenging American policy in ways were just beginning to reckon with. ... Americas aging government. Its not just the 71-year-old president: A POLITICO analysis finds that the federal workforce is ...
As we age, our bodys ability to fight free radicals reduces.. BIOCURCU can enhance the production of GLUTATHIONE, an important ... 3) Anti-Amyloid- BRAIN AGING - Alzheimers disease is considered a form of dementia, a brain disorder, that primarily involves ... Over time, as our cells continue to be affected by free radicals, or oxidants, they begin to degenerate and AGING is ... Because NF-kBs expression increases as we age, using BIOCURCU may help tomodulate the effects of NF_kB.. ...
... mechanisms of aging. In the session, Aging Mechanisms, two topics were discussed: first is aging at the organismal level, which ... A mutant model mouse is useful for studies of aging. The klotho phenotype (premature aging) is caused by a disruption of the ... Studies of the mutant mouse, klotho, showing premature aging, raise a possibility that mammals have an "anti-aging hormone." A ... Frontier experimental studies of aging at the molecular level are leading to fascinating hypotheses that aging is the price we ...
  • Throughout its history, the program has benefitted from a substantial base of financial support from the National Institute on Aging (NIA), and from the leadership of a visionary program officer at NIA, Richard Suzman. (
  • The ADEAR website helps users find Alzheimer's disease information and resources from the National Institute on Aging. (
  • Rafael de Cabo at the National Institute on Aging in Baltimore, Maryland, and a co-author on the 2006 Nature paper, says that he has safely tested one of the compounds, SRT1720, in more than 1,000 mice, some of which received the compound for two years. (
  • Researchers found that those who didn't sleep well exhibited more signs of skin aging including fine lines, uneven pigmentation and reduced skin elasticity. (
  • Recent efforts made by researchers from diverse fields have merged into a line of frontier sciences to search for the "absolute" mechanisms of aging. (
  • This has had a magnetic effect on the size, scope, and productivity of the program as new researchers have been drawn into the field by the prominent senior scholars already working on aging issues. (
  • The Sloan Center on Aging & Work at Boston College understands this need, and has invited international research fellows to connect with researchers in the United States to examine topics on aging in the workplace. (
  • For example, the Sloan Center and other partners have started collaborating with researchers from the Behavioural Science Institute of Radboud University Nijmegen, who have organized a Dutch knowledge platform on sustainable systems of support for aging workers ( ). (
  • Aging in the Wild takes us from the African savannah to the French Alps - and beyond - guided by passionate researchers who reveal their latest discoveries. (
  • Researchers found that seniors who have positive outlooks on aging are 40% more likely to recover from a disability than those with negative attitudes. (
  • Now, researchers at the Salk Institute for Biological Studies have replicated premature aging in the lab, allowing them to study aging-related disease in a dish. (
  • Researchers at the University of Miami are taking a different approach: They're studying the genes that allow people to stay healthy into old age. (
  • By focusing on Amish people who have lived to 80, the researchers hope to pinpoint the genes that promote "successful aging"-the ability to live without disease, depression, frailty, or loss of independence for longer than average. (
  • Researchers who study aging have long suspected that mitochondria play a role in aging. (
  • Not so long ago, researchers thought we aged the same way our cars do-after years of wear and tear, the engine is bound to break down. (
  • On Wednesday, some of the leading researchers in the field met at Harvard University to discuss the state of anti-aging science at the Aging & Healthy Lifespan conference. (
  • Researchers have found that by changing just one of the genes that affects aging, they were able to double the worm's lifespan. (
  • Researchers need to study the twin impacts of long-term HIV infection and aging to assess their impact on overall health and well-being. (
  • By pooling several quantitative biomarkers of aging researchers were able to predict the physical and mental performance of test subjects on tasks designed to assess their actual biological age. (
  • In a landmark study sure to provoke interest, researchers from the University of Edinburgh have regenerated an aged organ - in vivo, inside a living animal - to its youthful state though noninvasive manipulation of genes. (
  • and her talk will highlight the primary challenges that researchers face in understanding the key issues facing adults aging with I/DD. (
  • In the recent study, the researchers tested 10 flavonoids , which are naturally occurring compounds with antioxidant and anti-inflammatory properties, in aging mice. (
  • In the 1950s, researchers began to question the validity of accelerated aging tests which relied on dry heat and a single temperature, pointing out that relative humidity affects the chemical processes which produce paper degradation and that the reactions which cause degradation have different activation energies. (
  • This led researchers like Baer and Lindström to advocate accelerated aging techniques using the Arrhenius equation and a realistic relative humidity. (
  • But in a few states, the senior citizen population grew significantly faster than the rest of the country, according to a recent Administration on Aging report. (
  • The Administration on Aging (AoA) is the U.S. federal agency charged with administering the Older Americans Act (OAA), the principal federal legislation promoting client advocacy, system building, and the delivery of social services for America's elderly population. (
  • and insurance/benefits outreach and counseling program (Administration on Aging, ). (
  • To strengthen the involvement of the Administration on Aging in the development of policy alternatives in long-term care by participating in all departmental and interdepartmental activities concerning development of long-term-care health services, review all departmental regulations regarding community-based long-term care, and provide a leadership role for AoA, state, and area agencies in development and implementation of community-based long-term care. (
  • Eldercare Locator is a service by the U.S. Administration on Aging to help users find resources for older adults. (
  • Funded by the Administration on Aging, Dr. Eric Coleman's Care Transition Intervention (CTI) model was selected to be implemented in partnership with the Hospital of Central Connecticut (HCC). (
  • The Partnership for Health in Aging (PHA) was formed by the American Geriatrics Society to "to prepare America's formal and informal caregiving workforce to provide quality care for America's aging population, and to ensure the financial feasibility of providing that care. (
  • Accordingly, model animals in which a disruption of a single gene leads to the premature phenotype are useful and indispensable for aging studies. (
  • Upon directed differentiation of Progeria-derived iPS cells into smooth muscle cells the premature aging phenotype, including misshapen nuclei, the loss of gene silencing marks and compromised proliferation, reappeared. (
  • The Division of Aging supports the development of alternatives to nursing home care and coordinates services through the statewide INconnect Alliance network. (
  • Two decades have past since Caleb Finch in Longevity Senescence and the Genome exhaustively exposed the persistence of negligible senescence in nature and yet the dominant theories of aging continue to lack viable mechanisms or explanations for negligible senescence within their models. (
  • Meet species that exemplify all the realms of aging: longevity, reproductive health, social status, wisdom, and finally, everything that surrounds the final chapter of life, death. (
  • Most scientists who study human longevity search for genes that determine who is most likely to make it to age 100. (
  • One of the genetic factors that influences the rate of aging and longevity of an organism is the length of telomeres that. (
  • Because the company aims to market drugs that slow or prevent the diseases of aging rather than extend longevity, sirtuin activators' effects on lifespan may not matter. (
  • The largest of the grant programs is Title III, State and Community Programs, through which AoA works closely with a network of 9 federal regional offices, 57 state units on aging, 661 substate area agencies on aging, 228 Native American, Alaskan, and Hawaiian tribal organizations, and some 27,000 providers of services to elderly people. (
  • As such, it is charged with providing leadership within the aging network of state and area agencies and of service providers for the elderly, and with coordinating activities of other federal agencies involved with aging. (
  • In spite of the fact that the high degree of variability in lifespan across species strongly supports the concept that aging is under genetic control, all three of these theories essentially define senescence as beyond direct regulation by natural selection. (
  • Targeting the genes that control aging not only increases lifespan but seems to improve overall health-so that the animals remain vital as they live longer. (
  • When treating aging mice with fisetin, the team saw that it reduced the levels of senescent cells in the animals, prolonging their lifespan and contributing to better health. (
  • Our study is the first to conclusively demonstrate that inadequate sleep is correlated with reduced skin health and accelerates skin aging. (
  • What Is an Age-Friendly Health System? (
  • Accelerate your adoption of the 4Ms in a virtual community with other health systems and be recognized as an Age-Friendly Health System. (
  • The Division of Aging Biology (DAB) of the NIA funds Nathan Shock Centers of Excellence in the Basic Biology of Aging across the U.S. There are currently 5 funded Centers, in Maine (The Jackson Laboratory), Michigan (University of Michigan), Texas (University of Texas Health Sciences Center in San Antonio), Washington (University of Washington) and New York (Albert Einstein College of Medicine). (
  • What to Expect in your 50's, 60's, and 70's As we age, our health needs are constantly changing. (
  • How much exercise you need depends on your age and health. (
  • Major Goal: Consultants for the Honolulu as an Age-Friendly City Initiative, backed by the Mayor and World Health Organization. (
  • The Economics Of Aging Program involves research on the health and economic circumstances of individuals as they age, and on the implications of population aging on the well-being of older persons. (
  • The underlying focus of the program is the study of the health and financial well-being of people as they age, and the larger implications of a population that is increasingly composed of older people. (
  • The landscape of health and health care is changing rapidly as well, with lower disability rates by age, continuing advances in medical technology and disease management, increases in health care costs, and significant reforms in health policy. (
  • Health affects one's ability to work at older ages, and is strongly associated with financial well-being. (
  • Mental health issues such as depression and anxiety are NOT a normal part of aging and are hard to discuss, diagnose and treat. (
  • Linda Fried, dean of Columbia University's Mailman School of Public Health, points to a study of Swedish twins in the 1990s undertaken by the MacArthur Foundation, which popularized the term "successful aging. (
  • As we age, the repair team slacks off and our health deteriorates. (
  • AoA was created by Title II of the OAA, and is currently directed by the assistant secretary for aging within the office of the secretary of the Department of Health and Human Services (DHHS). (
  • The AOA has information for health professionals, caregivers, and for elders and families on a variety of aging-related topics. (
  • It includes information on the field of geriatrics as well as links to a physician finder tool and information on aging-related health topics. (
  • This is a service that helps find programs for people ages 55 and over that may pay for some of their costs of prescription drugs, health care, utilities, food, and other essential items or services. (
  • This CDC website has information on a variety of health and aging-related topics, including emergency preparedness, preventive care, advance care planning, chronic disease management, and more. (
  • This site for consumers from the National Library of Medicine includes information on senior health and links to other MedlinePlus pages on aging-related topics. (
  • This website from the National Institutes of Health presents aging-related health information for consumers on topics such as cancer, memory and mental health, vision and hearing, and many more. (
  • This comprehensive guide provides information on various health and lifestyle subjects associated with aging and old age. (
  • The 'Wear and Tear' theory of aging suggests that our health deteriorates due to usage and other external factors, similar to how the value of machinery depreciates. (
  • According to figures supplied by the Public Health Agency of Canada (PHAC), about 18% of new HIV cases are occurring among people aged 50 or older. (
  • Deb Wyeth with the Grundy County Health Department was named Care Coordinator of the Year in the State of Illinois by the Illinois Department on Aging! (
  • I'm a California girl, born and raised here, with an abiding interest in health issues and particularly, healthy aging. (
  • Books commissioned for the series should seek to encourage debate about the implications of the most pressing health, social welfare, economic, and other issues related to aging in various countries across the world. (
  • The complexity of aging has led to a plethora of ideas about the specific molecular and cellular causes and how these alterations lead to age-associated diseases, such as epithelial cancers. (
  • Also, the role of aging at the cellular level in the pathogenesis of age-associated diseases, such as arteriosclerotic vascular disease and many carcinomas, remain, for the most part, speculative. (
  • If safety systems fail, aging reactors could leak radiation, which may contaminate the water supply and cause life-threatening diseases and infections. (
  • So some scientists think a drug that targets one of those genes might amp up the repair work and thus help prevent or treat a host of age-related diseases like diabetes or heart disease. (
  • Earlier this year, a group at Pfizer published a study challenging the research that became the cornerstone of Sirtris, a high-profile company that is developing compounds to treat or prevent the diseases of aging. (
  • Here are my suggestions from yesterday's talk with the audience, mostly middle aged females with a few guys thrown in, about how to talk our aging parents into doing something we want and they don't. (
  • According to Dr Sergei Scherbov, a specialist in demographic analysis: "Two hundred years ago, a 60-year-old would be a very old person, [but] someone who is 60 years old today, I would argue, is middle-aged. (
  • The number of people living with the disease doubles every 5 years beyond age 65. (
  • What else did people in the Middle Ages know about gravity? (
  • I have read that in the Middle Ages people believed that angels pushed the Moon in its orbit, the angelic push presumably being in a tangential direction as per the Aristotelian belief that a force is needed to push an object in its direction of motion. (
  • Mild cognitive impairment (MCI) is a condition in which people face memory problems more often than that of the average person their age. (
  • Noteworthy people who had the surgery included Harold McCormick, chairman of the board of International Harvester Company, and the aging premier of Turkey. (
  • While working later in life may seem prudent financially, most people do not continue to work past the typical retirement age. (
  • Since the publication of the Origin of the Species, many people have attempted to identify the fundamental causes of aging. (
  • I asked the people in the audience what brought them to this event to talk about aging loved ones. (
  • The European Union reports increasing rates of participation in the labor force by people between the ages of 55 and 64. (
  • Research on Amish people reveals a link between a rare genetic pattern and healthy aging. (
  • But only haplogroup X was found to be prevalent among healthy aged people in the University of Miami study. (
  • But people like Appel seem to have a knack for graceful aging. (
  • At age 80 people generally have about 50% to 60% of the muscle mass they had when they were 30. (
  • We find that people who age successfully and have a good quality of life adapt well to changes,' Mosqueda says. (
  • According to more detailed Eurostat data, 17.4% of Europeans are aged 65 and over, 16.7% are children aged 14 and younger, and 65.8% are working-age people (aged 15 to 64), but even these numbers are averages, and don't give the full, nuanced picture. (
  • Ages are colour coded: yellow stands for the elderly, pink for children, and blue for working-age people. (
  • For example, Eastern Europe, particularly Poland and Slovakia, have large working-age populations (marked in turquoise and blue), in sharp contrast to the neighbouring Germany which has a high concentration of elderly people in its eastern part near the border with Poland. (
  • The Derek Zoolander Center for People Who Don't Age Good (DZCFPWDAG), a state-of-the-art, anti-aging center in New York City opens today at 4 pm. (
  • But how can design build stronger bonds between people of all ages? (
  • Furthermore, the CDC has forecasted that by the year 2020, more than 50% of HIV-positive people in the U.S. will be over the age of 50. (
  • It is not just the aging of people with longstanding HIV that is occurring. (
  • It is possible that as HIV-positive people age similar dose adjustments may be required. (
  • The burden of coping with multiple conditions may be difficult for some people as they strive to remain high functioning and yet are constrained by the effects of aging. (
  • An aging physician refusing to comply with a new form or yelling at a clerk once when asked to learn a new electronic medical record are inappropriate though not specific assessments for dementia. (
  • The implications of these demographic trends are extensive, yet they are just one part of a complex dynamic of changing factors affecting people's well-being as they age. (
  • However, these changes in the skin and facial features cannot be avoided as these are inevitable part of aging. (
  • This research shows for the first time, that poor sleep quality can accelerate signs of skin aging and weaken the skin's ability to repair itself at night," said Dr. Daniel Yarosh, a senior vice president at The Estée Lauder Companies, in a press release. (
  • The Centers provide leadership in the pursuit of basic research into the biology of aging. (
  • His own research program is nothing if not ambitious: He wants to reverse aging in humans. (
  • What impact will your work have on aging research? (
  • The dysfunction address of age to buy viagra research is doctor well better and to a direct left- online as looked at than major uses. (
  • There are many organizations dedicated to research on aging, advocating for the elderly, and promoting healthy aging. (
  • However, research on spirituality struggles to maintain a nonsectarian approach to studying spirituality, owing to the highly heated religious preferences of various authors, [ 17 ] which polarize gerontological literature on spirituality, religiosity and aging. (
  • Today, the substantive importance of research on aging has never been greater. (
  • Over the last 28 years, the NBER's Program on the Economics of Aging has helped to transform this field from an exploratory new research area into a well-recognized and influential subfield of the economics profession. (
  • NIA's recognition of the analytic value of economic research in aging and its support for a highly integrated program of investigators working collaboratively on aging issues was path-breaking. (
  • This support has been critical to development of the NBER program, the research subfield, and our understanding more generally of people's well-being as they age. (
  • The NBER's Aging Program continues to be anchored by NIA Center and Program Project grants, and by multiple NIA-funded research projects that are administered under the coordinating umbrella of the program. (
  • The program has thrived through its history by simultaneously recruiting and inspiring some of the most prominent, established economics scholars along with more emerging scholars to develop a research agenda on economic issues related to aging. (
  • The program has also been leveraged by substantial research development support provided by NIA, including an NIA-funded training program on the economics of aging and NIA funding for pilot projects. (
  • The training program alone has supported about 150 investigators, the large majority of whom have developed a long-term research agenda on the economics of aging. (
  • In research to be published in The Netherlands later this year ( De Lange, Schalk, Van der Heijden, 2013 ), we discuss negative "push" factors that make it hard for aging workers to stay in their jobs. (
  • A piece in Nature outlines the rather technical arguments over Sirtris's sirtuin activators and what it might mean for the company and for anti-aging research more broadly. (
  • New research is showing the properties of a chemical present in red wine, known as resveratrol, does indeed have anti-aging properties. (
  • Aging is defined at many levels, from the mitotic age of cells to the organismal-wide aging of tissues and organs. (
  • Underlying all of these theories is the assumption that aging occurs from the bottom-up, beginning with damage to DNA and proteins and ending with organismal frailty, disability, and disease. (
  • Campisi J (2005) Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors. (
  • In the session, Aging Mechanisms , two topics were discussed: first is aging at the organismal level, which is genetically determined, and the second focused on the mechanisms by which cells know when to stop their proliferation. (
  • In this chapter, the current status of cellular aging will be discussed at a level that will provide geriatricians with a foundation of knowledge to assist them in following future developments in the field of basic gerontology. (
  • The two most important keys to successful aging are diet and exercise , says John Faulkner, PhD, senior researcher at the Muscle Mechanics Laboratory in the Institute of Gerontology and professor of physiology and biomedical engineering at the University of Michigan in Ann Arbor. (
  • Age-associated epithelial cancers, such as breast cancer , colon cancer, and prostate cancer , however, contribute significantly to the morbidity and mortality of the elderly and are the second leading cause of death. (
  • According to the National Alliance for Caregiving (NAC), there are 44 million family caregivers, which is nearly 20 percent of the adult population in the U.S. These caregivers, who are often over the age of 50, provide physical and financial assistance to their elderly loved ones-the NAC also found that while women provide the lion's share of basic care, men also provide financial assistance. (
  • The mission of the Winchendon Council on Aging is to enrich the lives of the community senior population by providing educational programs, recreational activities, referral and social services assistance and to advocate for our seniors while educating the community of the needs of its elderly. (
  • With the Area Agency on Aging acting as an advocate, awareness of the needs of the elderly increases through services that assist the elderly and their families with options that promote independence, well-being and dignity. (
  • The symptoms of the disease can first appear after age 60 and the risk increases with age. (
  • In addition, the secondary esophageal peristalsis, which constitute a major clearence mechanism for refluxed gastric acid, seems to be evoked less frequently and less consistently, this increases the liklyhood of the occurrence of gastroesophageal reflux with age. (
  • The population in the United States is aging. (
  • Speech-language pathologists play an important role in working with this aging population. (
  • SLPs should take the initiative to learn more about the aging population and prepare for the increased services this group will demand in the future. (
  • Given the advancing median age of the European population, this trend is welcome. (
  • As Figure 1 shows, 47.4 percent of the European Union population between the ages of 55 and 64 are working, but this means that 52.6 percent are not-a serious loss of human capital. (
  • It may also help prevent or treat heart disease in the general aging population. (
  • In fact, vascular smooth muscle cell senescence also plays a role in advanced arteriosclerosis within the normal aging population. (
  • This is the age structure of European population. (
  • Europe is ageing: according to UN estimates, half the region's population are aged 43 and over. (
  • This is consistent with the UN data on total fertility rates (TFR, average number of births per woman of fertile age) in this part of Europe, at around 1.3 in Spain, Portugal and Italy, far below the fertility rate of 2.1 required for simple continuation of the population. (
  • The authors report on national demographic trends, examine the current living conditions of the aged population, explain the structure of the retirement system, and offer estimates of future budgetary costs of the public programs. (
  • An aging society is characterized by a growing proportion of the retired to the active working population. (
  • I'm sure you have seen many actress who never age, and proven it can be done either naturally, or with creams and supplements. (
  • It's not surprising that this demographic is often bombarded by the media with anti-aging everything: skin creams for every part of our bodies, miracle "cures" for our wrinkles, youthful colors for our hair. (
  • Creams are usually a good choice for aging skin. (
  • Everywhere you turn in the beauty isles of Walmart are signs and advertisements for "anti-aging" creams, and wrinkle reducing makeup. (
  • i ) Despite the fact that klotho mutant mice show systemic aging phenotypes, only limited organs express the klotho gene endogenously. (
  • New study shows that resveratrol reduces age-induced deterioration of neuromuscular synapses in mice. (
  • The level of investigative activity into the mechanisms of aging at the cellular and molecular level has increased dramatically during the past two to three decades. (
  • Investigative efforts in the area of cellular aging address a number of questions, the answers to which are only beginning to emerge. (
  • While definitive answers to the questions posed above are not forthcoming at the present time, there is enough information to permit some speculation about future directions that may be pursued in the area of cellular aging. (
  • Schneider EL, Mitsui Y. The relationship between in vitro cellular aging and in vivo human age. (
  • The long-anticipated aging of the baby boom generation across the threshold of eligibility for Social Security and Medicare has arrived. (
  • The website includes information on topics such as aging, eldercare, and Medicare. (
  • The Division of Aging strives to foster networks that provide information, access and long-term care options that enhance choice, autonomy and quality of life for Hoosiers. (
  • The Division of Aging is committed to helping Hoosiers find the information and resources they need. (
  • These connections between sleep and skin aging, now supported with solid scientific data, will have a profound effect on how we study skin and its functions. (
  • In aging, degradation of white matter structure has emerged as an important general factor, further focusing attention on the critical white matter connections. (
  • We're looking not just to predict how old you'll get, but how well you'll age," says William K. Scott, professor of human genetics at the university's school of medicine. (
  • Crawford says it's hard to parse whether environment and lifestyle play as much of a role in successful aging as genetics, especially when the control group comes from the same community as the experimental group. (
  • The overall role of genetics in successful aging remains controversial. (
  • The study examines the pension-related aging problem primarily from a fiscal perspective. (
  • NAPGCM is becoming the Aging Life Care Association (ALCA) to better reflect the broad spectrum of services and expertise offered by its members. (
  • Councils on Aging (COAs) are the community focal point for social and support services to elders, families and caregivers in 349 cities and towns in Massachusetts. (
  • This website has a section for consumers, which includes a directory of homes and services, and other information on aging services. (
  • an alternative notion is that the manifestations of aging are the summation of subtle decrements of function in most or all of the cell populations in the body. (
  • This paper discusses a study analyzing aging populations and public pension schemes. (
  • Caregivers helping an aging parent may be recruited to care for a pet right along with caring for its owner. (
  • However, we have recently started to learn the molecular mechanisms that control aging. (
  • Clearly, important additional mechanisms are involved in the regulation of aging. (
  • During the age work, she tells some years that bob and legally lee sold their consultation to paul, prompting the levitra to attack them. (
  • The NBER's Program on the Economics of Aging began in 1986, when the baby boom generation was between the ages of 22 and 40, and when life expectancy at age 62 (the age of eligibility for Social Security) was nearly three years shorter than it is today. (
  • However, in recent years, many experimental results that contradict this concept by demonstrating increased life-span with increased reproductive capacity leaves this question in aging theory unresolved. (
  • For some years I have been giving thought to the matter of age and aging . (
  • Sue and Gigi started an anti-aging beauty blog about 3 years ago then dropped it.Many friends and followers talked us into starting up again, hence, (
  • The "gang-bangers" ranged in age from 14 to 20, and the "hardcores," who were between 18 to 20 and up, with few over 24 or 25 years old. (
  • In 1929, a frequently used method in which 72 hours at 100 degrees Celsius is considered equivalent to 18-25 years of natural aging was established by R. H. Rasch. (
  • A family lineage exhibiting progeria (premature aging) indicates that senescence is, at least to some extent, controlled genetically. (
  • The klotho gene encodes a novel protein that appears to function outside of the cells (secreted protein), and thus it is very different from that involved in previously described premature-aging syndromes and cell senescence, which function in the nucleus. (
  • A theory of aging is proposed challenging the concept that economic trade-offs between body repair and reproduction are the primary drivers of senescence. (
  • Relative to aging theory this has remained problematic because It has not been intuitively obvious how senescence can function as a trait that favors the fitness of the individual. (
  • This paper, "Mate-Selection Scale And Aging" (MSSA) describes an additional significant mechanism of aging and provides the rational for the species specific rates of senescence that we see across species from the very short lived to the negligibly senescent. (
  • The visible signs of old age and fragility, what scientists call senescence, do not always present themselves in the same way. (
  • A clinical trial commissioned by Estée Lauder and conducted by physician-scientists at University Hospitals (UH) Case Medical Center found that poor sleepers demonstrated increased signs of skin aging . (
  • On November 1, 1979, a small federal grant gave birth to the National Asian Pacific Center on Aging. (
  • The UH Center on Aging and Hawaii Pacific Gerontological Society is proud to announce a scholarship for students with a serious interest in a career in aging, long-term care, and/or death and dying. (
  • Center on Aging, University of Hawaii at Manoa. (
  • It's a serious problem, and it is one of a number of problems that I would call 'aging aircraft' issues that we face with these vehicles,' shuttle program manager Wayne Hale said. (
  • Various issues such as wrinkling, sagging skin, and other problems of aging skin are dealt with on this page. (