The study of those aspects of energy and matter in terms of elementary principles and laws. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
Methods and procedures for the diagnosis of diseases of the nervous system, central and peripheral, or demonstration of neurologic function or dysfunction.
Any significant change in measures of climate (such as temperature, precipitation, or wind) lasting for an extended period (decades or longer). It may result from natural factors such as changes in the sun's intensity, natural processes within the climate system such as changes in ocean circulation, or human activities.
Process whereby a cell, bodily structure, or organism (animal or plant) receives or detects a gravity stimulus. Gravity sensing plays an important role in the directional growth and development of an organism (GRAVITROPISM).
An independent Federal agency established in 1958. It conducts research for the solution of problems of flight within and outside the Earth's atmosphere and develops, constructs, tests, and operates aeronautical and space vehicles. (From U.S. Government Manual, 1993)
Elements of limited time intervals, contributing to particular results or situations.
The ratio of the density of a material to the density of some standard material, such as water or air, at a specified temperature.
The physiologic or functional barrier to GASTROESOPHAGEAL REFLUX at the esophagogastric junction. Sphincteric muscles remain tonically contracted during the resting state and form the high-pressure zone separating the lumen of the ESOPHAGUS from that of the STOMACH. (Haubrich et al, Bockus Gastroenterology, 5th ed., pp399, 415)
The structure at the pharyngoesophageal junction consisting chiefly of the CRICOPHARYNGEUS MUSCLE. It normally occludes the lumen of the ESOPHAGUS, except during SWALLOWING.
Measurement of the pressure or tension of liquids or gases with a manometer.
The area covering the terminal portion of ESOPHAGUS and the beginning of STOMACH at the cardiac orifice.
The muscular membranous segment between the PHARYNX and the STOMACH in the UPPER GASTROINTESTINAL TRACT.
Disorders affecting the motor function of the UPPER ESOPHAGEAL SPHINCTER; LOWER ESOPHAGEAL SPHINCTER; the ESOPHAGUS body, or a combination of these parts. The failure of the sphincters to maintain a tonic pressure may result in gastric reflux of food and acid into the esophagus (GASTROESOPHAGEAL REFLUX). Other disorders include hypermotility (spastic disorders) and markedly increased amplitude in contraction (nutcracker esophagus).
A movement, caused by sequential muscle contraction, that pushes the contents of the intestines or other tubular organs in one direction.
The normal length of time of an organism's life.
A glycoprotein secreted by the cells of the GASTRIC GLANDS that is required for the absorption of VITAMIN B 12 (cyanocobalamin). Deficiency of intrinsic factor leads to VITAMIN B 12 DEFICIENCY and ANEMIA, PERNICIOUS.
The decrease in the cell's ability to proliferate with the passing of time. Each cell is programmed for a certain number of cell divisions and at the end of that time proliferation halts. The cell enters a quiescent state after which it experiences CELL DEATH via the process of APOPTOSIS.
The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
DNA analogs containing neutral amide backbone linkages composed of aminoethyl glycine units instead of the usual phosphodiester linkage of deoxyribose groups. Peptide nucleic acids have high biological stability and higher affinity for complementary DNA or RNA sequences than analogous DNA oligomers.
Stable cobalt atoms that have the same atomic number as the element cobalt, but differ in atomic weight. Co-59 is a stable cobalt isotope.
A megaloblastic anemia occurring in children but more commonly in later life, characterized by histamine-fast achlorhydria, in which the laboratory and clinical manifestations are based on malabsorption of vitamin B 12 due to a failure of the gastric mucosa to secrete adequate and potent intrinsic factor. (Dorland, 27th ed)
NATIONAL LIBRARY OF MEDICINE service for health professionals and consumers. It links extensive information from the National Institutes of Health and other reviewed sources of information on specific diseases and conditions.
Value of all final goods and services produced in a country in one year.
An agency of the NATIONAL INSTITUTES OF HEALTH concerned with overall planning, promoting, and administering programs pertaining to advancement of medical and related sciences. Major activities of this institute include the collection, dissemination, and exchange of information important to the progress of medicine and health, research in medical informatics and support for medical library development.
Includes the spectrum of human immunodeficiency virus infections that range from asymptomatic seropositivity, thru AIDS-related complex (ARC), to acquired immunodeficiency syndrome (AIDS).
Based on known statistical data, the number of years which any person of a given age may reasonably expected to live.
A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.
The capability of an organism to survive and reproduce. The phenotypic expression of the genotype in a particular environment determines how genetically fit an organism will be.
The process of cumulative change at the level of DNA; RNA; and PROTEINS, over successive generations.
Genetic loci associated with a QUANTITATIVE TRAIT.
A form of gene interaction whereby the expression of one gene interferes with or masks the expression of a different gene or genes. Genes whose expression interferes with or masks the effects of other genes are said to be epistatic to the effected genes. Genes whose expression is affected (blocked or masked) are hypostatic to the interfering genes.
Differential and non-random reproduction of different genotypes, operating to alter the gene frequencies within a population.
Theoretical representations that simulate the behavior or activity of genetic processes or phenomena. They include the use of mathematical equations, computers, and other electronic equipment.
Facilities that convert NUCLEAR ENERGY into electrical energy.
Units that convert some other form of energy into electrical energy.
Nuclear power accident that occurred following the Tohoku-Kanto earthquake of March 11, 2011 in the northern region of Japan.
The gradual destruction of a metal or alloy due to oxidation or action of a chemical agent. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
Unstable isotopes of cesium that decay or disintegrate emitting radiation. Cs atoms with atomic weights of 123, 125-132, and 134-145 are radioactive cesium isotopes.
Radioactive substances which act as pollutants. They include chemicals whose radiation is released via radioactive waste, nuclear accidents, fallout from nuclear explosions, and the like.
Pollutants, present in soil, which exhibit radioactivity.

The expiry date of man: a synthesis of evolutionary biology and public health. (1/31363)

In industrialised countries, mortality and morbidity are dominated by age related chronic degenerative diseases. The health and health care needs of future populations will be heavily determined by these conditions of old age. Two opposite scenarios of future morbidity exist: morbidity might decrease ("compress"), because life span is limited, and the incidence of disease is postponed. Or morbidity might increase ("expand"), because death is delayed more than disease incidence. Optimality theory in evolutionary biology explains senescence as a by product of an optimised life history. The theory clarifies how senescence is timed by the competing needs for reproduction and survival, and why this leads to a generalised deterioration of many functions at many levels. As death and disease are not independent, future morbidity will depend on duration and severity of the process of senescence, partly determined by health care, palliating the disease severity but increasing the disease duration by postponing death. Even if morbidity might be compressed, health care needs will surely expand.  (+info)

Developmental synaptic changes increase the range of integrative capabilities of an identified excitatory neocortical connection. (2/31363)

Excitatory synaptic transmission between pyramidal cells and fast-spiking (FS) interneurons of layer V of the motor cortex was investigated in acute slices by using paired recordings at 30 degrees C combined with morphological analysis. The presynaptic and postsynaptic properties at these identified central synapses were compared between 3- and 5-week-old rats. At these two postnatal developmental stages, unitary EPSCs were mediated by the activation of AMPA receptors with fast kinetics at a holding potential of -72 mV. The amplitude distribution analysis of the EPSCs indicates that, at both stages, pyramidal-FS connections consisted of multiple functional release sites. The apparent quantal size obtained by decreasing the external calcium ([Ca2+]e) varied from 11 to 29 pA near resting membrane potential. In young rats, pairs of presynaptic action potentials elicited unitary synaptic responses that displayed paired-pulse depression at all tested frequencies. In older animals, inputs from different pyramidal cells onto the same FS interneuron had different paired-pulse response characteristics and, at most of these connections, a switch from depression to facilitation occurred when decreasing the rate of presynaptic stimulation. The balance between facilitation and depression endows pyramidal-FS connections from 5-week-old animals with wide integrative capabilities and confers unique functional properties to each synapse.  (+info)

Low resting potential and postnatal upregulation of NMDA receptors may cause Cajal-Retzius cell death. (3/31363)

Using in situ patch-clamp techniques in rat telencephalic slices, we have followed resting potential (RP) properties and the functional expression of NMDA receptors in neocortical Cajal-Retzius (CR) cells from embryonic day 18 to postnatal day 13, the time around which these cells normally disappear. We find that throughout their lives CR cells have a relatively depolarized RP (approximately -50 mV), which can be made more hyperpolarized (approximately -70 mV) by stimulation of the Na/K pump with intracellular ATP. The NMDA receptors of CR cells are subjected to intense postnatal upregulation, but their similar properties (EC50, Hill number, sensitivity to antagonists, conductance, and kinetics) throughout development suggest that their subunit composition remains relatively homogeneous. The low RP of CR cells is within a range that allows for the relief of NMDA channels from Mg2+ blockade. Our findings are consistent with the hypothesis that CR cells may degenerate and die subsequent to uncontrolled overload of intracellular Ca2+ via NMDA receptor activation by ambient glutamate. In support of this hypothesis we have obtained evidence showing the protection of CR cells via in vivo blockade of NMDA receptors with dizocilpine.  (+info)

Somatic recording of GABAergic autoreceptor current in cerebellar stellate and basket cells. (4/31363)

Patch-clamp recordings were performed from stellate and basket cells in rat cerebellar slices. Under somatic voltage clamp, short depolarizing pulses were applied to elicit action potentials in the axon. After the action potential, a bicuculline- and Cd2+-sensitive current transient was observed. A similar response was obtained when eliciting axonal firing by extracellular stimulation. With an isotonic internal Cl- solution, the peak amplitude of this current varied linearly with the holding potential, yielding an extrapolated reversal potential of -20 to 0 mV. Unlike synaptic or autaptic GABAergic currents obtained in the same preparation, the current transient had a slow rise-time and a low variability between trials. This current was blocked when 10 mM BAPTA was included in the recording solution. In some experiments, the current transient elicited axonal action potentials. The current transient was reliably observed in animals aged 12-15 d, with a mean amplitude of 82 pA at -70 mV, but was small and rare in the age group 29-49 d. Numerical simulations could account for all properties of the current transient by assuming that an action potential activates a distributed GABAergic conductance in the axon. The actual conductance is probably restricted to release sites, with an estimated mean presynaptic current response of 10 pA per site (-70 mV, age 12-15 d). We conclude that in developing rats, stellate and basket cell axons have a high density of GABAergic autoreceptors and that a sizable fraction of the corresponding current can be measured from the soma.  (+info)

Fas/Apo [apoptosis]-1 and associated proteins in the differentiating cerebral cortex: induction of caspase-dependent cell death and activation of NF-kappaB. (5/31363)

The developing cerebral cortex undergoes a period of substantial cell death. The present studies examine the role of the suicide receptor Fas/Apo[apoptosis]-1 in cerebral cortical development. Fas mRNA and protein are transiently expressed in subsets of cells within the developing rat cerebral cortex during the peak period of apoptosis. Fas-immunoreactive cells were localized in close proximity to Fas ligand (FasL)-expressing cells. The Fas-associated signaling protein receptor interacting protein (RIP) was expressed by some Fas-expressing cells, whereas Fas-associated death domain (FADD) was undetectable in the early postnatal cerebral cortex. FLICE-inhibitory protein (FLIP), an inhibitor of Fas activation, was also expressed in the postnatal cerebral cortex. Fas expression was more ubiquitous in embryonic cortical neuroblasts in dissociated culture compared to in situ within the developing brain, suggesting that the environmental milieu partly suppresses Fas expression at this developmental stage. Furthermore, FADD, RIP, and FLIP were also expressed by subsets of dissociated cortical neuroblasts in culture. Fas activation by ligand (FasL) or anti-Fas antibody induced caspase-dependent cell death in primary embryonic cortical neuroblast cultures. The activation of Fas was also accompanied by a rapid downregulation of Fas receptor expression, non-cell cycle-related incorporation of nucleic acids and nuclear translocation of the RelA/p65 subunit of the transcription factor NF-kappaB. Together, these data suggest that adult cortical cell number may be established, in part, by an active process of receptor-mediated cell suicide, initiated in situ by killer (FasL-expressing) cells and that Fas may have functions in addition to suicide in the developing brain.  (+info)

Metrifonate increases neuronal excitability in CA1 pyramidal neurons from both young and aging rabbit hippocampus. (6/31363)

The effects of metrifonate, a second generation cholinesterase inhibitor, were examined on CA1 pyramidal neurons from hippocampal slices of young and aging rabbits using current-clamp, intracellular recording techniques. Bath perfusion of metrifonate (10-200 microM) dose-dependently decreased both postburst afterhyperpolarization (AHP) and spike frequency adaptation (accommodation) in neurons from young and aging rabbits (AHP: p < 0.002, young; p < 0.050, aging; accommodation: p < 0.024, young; p < 0.001, aging). These reductions were mediated by muscarinic cholinergic transmission, because they were blocked by addition of atropine (1 microM) to the perfusate. The effects of chronic metrifonate treatment (12 mg/kg for 3 weeks) on CA1 neurons of aging rabbits were also examined ex vivo. Neurons from aging rabbits chronically treated with metrifonate had significantly reduced spike frequency accommodation, compared with vehicle-treated rabbits. Chronic metrifonate treatment did not result in a desensitization to metrifonate ex vivo, because bath perfusion of metrifonate (50 microM) significantly decreased the AHP and accommodation in neurons from both chronically metrifonate- and vehicle-treated aging rabbits. We propose that the facilitating effect of chronic metrifonate treatment on acquisition of hippocampus-dependent tasks such as trace eyeblink conditioning by aging subjects may be caused by this increased excitability of CA1 pyramidal neurons.  (+info)

Thiamine deficiency is prevalent in a selected group of urban Indonesian elderly people. (7/31363)

This cross-sectional study involved 204 elderly individuals (93 males and 111 females). Subjects were randomly recruited using a list on which all 60-75 y-old-people living in seven sub-villages in Jakarta were included. The usual food intake was estimated using semiquantitative food frequency questionnaires. Hemoglobin, plasma retinol, vitamin B-12, red blood cell folate and the percentage stimulation of erythrocyte transketolase (ETK), as an indicator of thiamine status, were analyzed. Median energy intake was below the assessed requirement. More than 75% of the subjects had iron and thiamine intakes of approximately 2/3 of the recommended daily intake, and 20.2% of the study population had folate intake of approximately 2/3 of the recommended daily intake. Intakes of vitamins A and B-12 were adequate. Biochemical assessments demonstrated that 36.6% of the subjects had low thiamine levels (ETK stimulation > 25%). The elderly men tended to have lower thiamine levels than the elderly women. The overall prevalence of anemia was 28.9%, and the elderly women were affected more than the elderly men. Low biochemical status of vitamins A, B-12 and RBC folate was found in 5.4%, 8.8 % and 2.9% of the subjects, respectively. Dietary intakes of thiamine and folate were associated with ETK stimulation and plasma vitamin B-12 concentration (r = 0.176, P = 0.012 and r = 0.77, P = 0.001), respectively. Results of this study suggest that anemia, thiamine and possibly vitamin B-12 deficiency are prevalent in the elderly living in Indonesia. Clearly, micronutrient supplementation may be beneficial for the Indonesian elderly population living in underprivileged areas.  (+info)

High-linoleate and high-alpha-linolenate diets affect learning ability and natural behavior in SAMR1 mice. (8/31363)

Semipurified diets incorporating either perilla oil [high in alpha-linolenate, 18:3(n-3)] or safflower oil [high in linoleate, 18:2(n-6)] were fed to senescence-resistant SAMR1 mouse dams and their pups. Male offspring at 15 mo were examined using behavioral tests. In the open field test, locomotor activity during a 5-min period was significantly higher in the safflower oil group than in the perilla oil group. Observations of the circadian rhythm (48 h) of spontaneous motor activity indicated that the safflower oil group was more active than the perilla oil group during the first and second dark periods. The total number of responses to positive and negative stimuli was higher in the safflower oil group than in the perilla oil group in the light and dark discrimination learning test, but the correct response ratio was lower in the safflower oil group. The difference in the (n-6)/(n-3) ratios of the diets reflected the proportions of (n-6) polyunsaturated fatty acids, rather than those of (n-3) polyunsaturated fatty acids in the brain total fatty acids, and in the proportions of (n-6) and (n-3) polyunsaturated fatty acids in the total polyunsaturated fatty acids of the brain phospholipids. These results suggest that in SAMR1 mice, the dietary alpha-linolenate/linoleate balance affects the (n-6)/(n-3) ratio of brain phospholipids, and this may modify emotional reactivity and learning ability.  (+info)

TY - JOUR. T1 - Age-associated Differences in Cardiovascular Inflammatory Gene Induction during Endotoxic Stress. AU - Saito, Hiroshi. AU - Papaconstantinou, John. PY - 2001/8/3. Y1 - 2001/8/3. N2 - Upon physiological stress, families of stress response genes are activated as natural defense mechanisms. Here, we show that induction of specific inflammatory genes is significantly dysregulated and altered in the heart of aged (24-26-month-old) versus young (4-month-old) mice experimentally challenged with a bacterial endotoxin, lipopolysaccharide (LPS, 1.5 mg/kg of body mass). Whereas the LPS-mediated induction of cardiac mRNA for tumor necrosis factor α or inducible nitric-oxide synthase showed no age-associated differences, the induction of interleukin-1β (IL-1β) and intracellular adhesion molecule-1 was modestly extended with aging, and the induction of IL-6 was significantly prolonged with aging. This age-associated phenomenon occurred gradually from 4 to 17 months of age and became more ...
Musculoskeletal conditions are a major burden on individuals, healthcare systems, and social care systems throughout the world, with indirect costs having the predominant economic impact. Aging is a major contributing factor to the development and progression of arthritic and musculoskeletal diseases. Indeed, aging and inflammation (often referred to as inflammaging) are critical risk factors for the development of osteoarthritis (OA), which is one the most common forms of joint disease. The term chondrosenescence has recently been introduced to define the age-dependent deterioration of chondrocyte function and how it undermines cartilage function in OA. An important component of chondrosenescence is the age-related deregulation of subcellular signalling pathways in chondrocytes. This mini-review discusses the role of age-related alterations in chondrocyte signaling pathways. In this article we focus our attention on two major areas: age-dependent alterations in transforming growth factor-β ...
Investigations of intracellular signaling revealed reduced phosphorylation of AKT in MDDCs from aging, suggesting decreased activation of PI3kinase signaling pathway. Since PI3K signaling pathway plays a positive regulatory role in phagocytosis and migration, and it also functions as a negative regulator of TLR signaling by inducing activation of p38 MAP kinase, this may explain the aberrant innate immune functioning of DCs from aged subjects. Results further revealed an increased expression of PTEN, a negative regulator of PI3Kinase signaling pathway, in MDDCs from aged subjects. Increased PTEN may thus be responsible for the defect in AKT phosphorylation and therefore, altered innate immune response of DCs from aged humans.. This study is supported in part by a grant AG027512 from NIH and partly by new scholar grant from the Ellison Medical Foundation. ...
Voltage-gated sodium channels (VGSCs) generate the Na+ current (INa) responsible for the cardiac action potential upstroke largely due to the cardiac isoform Nav1.5, but other isoforms are responsible for ˜20% of the upstroke and a component of a sustained sodium current. This sustained component has been attributed with an increasing arrhythmia risk, particularly within the elderly and has been the target of development for new anti-arrhythmic drugs. Our study has investigated the age-associated changes in protein density and localisation of the VGSC alpha-subunits Nav1.5 and Nav1.4 in the rat heart.. Rats at 6, 12 and 28 months of age were sacrificed, their hearts dissected into the regions of left and right ventricle, left and right atria, epicardium and endocardium (n = 5). These regions were analysed by western blot to determine the protein expression of Nav1.5 and Nav1.4 (Alomone, Israel), normalised to the expression of desmin (Dako, UK). Immunocytochemistry of single cardiac myocytes ...
Researchers at Mayo Clinic have shown that eliminating cells that accumulate with age could prevent or delay the onset of age-related disorders and disabilities. The study, performed in mouse models, provides the first evidence ...
Greater social contact and support are associated with better cognitive functioning, whereas greater conflict is associated with lower cognitive functioning.. Diseases either caused by or associated with aging - particularly vascular changes - play a larger role in age-related cognitive changes than is often acknowledged.. This collection of articles, titled Cognition, Health, and Aging: Integrating Perspectives Across Disciplines, is based on papers presented at a conference held at Penn State University in 2009. Funding for the supplemental issue was provided by the National Institute on Aging through the resources of the Center on Population Health and Aging at Penn State University, and the National Academies Keck Futures Initiative grant, Health and Healthspan in Longitudinal Studies of Aging.. The Journals of Gerontology Series B: Psychological Sciences and Social Sciences is a refereed publication of The Gerontological Society of America (GSA), the nations oldest and largest ...
BACKGROUND. Cancer incidence typically increases with age, but it is not known whether ethnic characteristics influence the age dependence of squamous cell carcinoma of the skin (SCC). OBJECTIVES. (i) To determine the age dependence of SCC in the black African, coloured and white population groups of South Africa (SA); and (ii) to show whether any differences in the rate of change of age dependence could be influenced by diversity in behaviour and lifestyle, especially with regard to the prevalence of HIV infection, rather than by a fundamental variation in cancer biology between the populations. METHODS. Linear regression analysis was applied to the logarithm of the age-specific incidence rates for SCC v. the logarithm of age between 35 and 74 years. The slopes of the regression (age exponent) were compared for each subset of gender, population group and year of diagnosis (between 2000 and 2010). RESULTS. The most notable feature was the low value of the age exponent in both male and female ...
Age-related effects on the default mode network (DMN) connectivity as measured at rest using functional magnetic resonance imaging (fMRI) are now well described. Little is known however about the relationships between these changes and age-related effects on cognition or on the unconstrained thoughts which occur during the resting-state scan, called inner experience. Brain resting-state activity, inner experience, and cognitive ability measurements were obtained in 70 participants aged 19-80 years. The anterior-posterior disruption of DMN activity with age reported in previous studies was recovered here. A significant effect of age was also found on cognitive abilities but not on inner experience. Finally, age-related changes in DMN connectivity were found to correlate with cognitive abilities, and more specifically with autobiographical memory performance. These findings provide new information to fuel the debate on the role of the brain default mode and more specifically on the effect of age-related
The retinal hypoperfusion found in the present study is also in support of the cerebral hypoperfusion, which occurs during normal aging (Table 4).1,5,11,22 Chen et al.1 studied the age-related reduction of CBF during normal aging in a cohort of normal subjects and found that the CBF as an indirect measurement of brain perfusion declined at a rate of −0.38% per year when the entire cortex was examined. Meanwhile, the cortical grey matter volume decreased at a rate of −0.85% per year, which exceeds the reductions in CBF.1 Leenders et al.5 reported that the CBF, cerebral blood volume, and cerebral metabolic rates of oxygen decline at a rate of −0.5% per year during normal aging. The changing rate of the RTP (−0.47% per year), RBF (−0.41% per year), and VVDd (−0.44% per year) found in the present study well matches the CBF change rates reported by Chen et al.1 and Leenders et al.,5 indicating that the RTP, RBF, and VVDd may be good candidates for imaging markers of the age-related ...
Huber, N., Sakai, N., Eismann, T., Shin, T., Kuboki, S., Blanchard, J., Schuster, R., Edwards, M. J., Wong, H. R. and Lentsch, A. B. (2009), Age-related decrease in proteasome expression contributes to defective nuclear factor-κB activation during hepatic ischemia/reperfusion. Hepatology, 49: 1718-1728. doi: 10.1002/hep.22840 ...
Age-related alterations in brain structure and function have been challenging to link to cognition due to potential overlapping influences of multiple neurobiological cascades. We examined multiple brain markers associated with age-related variation in cognition. Clinically normal older humans aged 65-90 from the Harvard Aging Brain Study (N = 186) were characterized on a priori magnetic resonance imaging markers of gray matter thickness and volume, white matter hyperintensities, fractional anisotropy (FA), resting-state functional connectivity, positron emission tomography markers of glucose metabolism and amyloid burden, and cognitive factors of processing speed, executive function, and episodic memory. Partial correlation and mediation analyses estimated age-related variance in cognition shared with individual brain markers and unique to each marker. The largest relationships linked FA and striatum volume to processing speed and executive function, and hippocampal volume to episodic memory. ...
In the past two decades neuroimaging studies have tried to unveil the neural mechanisms behind age-related changes in cognitive strategies and performance. Structural imaging studies have shown that brain volume changes throughout the complete life-span and functional imaging studies have reported age-related differences in brain activation and connectivity. ... read more The aim of this thesis was to provide an overview of studies that report age-related changes in brain activation as measured with functional MRI in a longitudinal design in healthy subjects. We found 16 studies of which 11 reported changes in activity over time. The majority of studies was performed in children. fMRI task used varied between attention, language, memory, working memory and sensory processing tasks. We found increases and decreases in activation in children between 5 and 20 and adults above age 50. A trend of left-hemispheric increases were shown for children around age 8, adults around age 66 and in language ...
After exclusion of.... confounders, most studies show similar results: A clear, age-dependent decline in serum Thyroid Stimulating Hormone (TSH) and (free) T3 ....[2] In the elderly, Thyroid hormones levels are usually within the lower part of normal values reported in the general population.[4] There is evidence that the decreased thyroid hormone levels observed in aging are due to lower TSH concentrations, and that lower TSH concentrations may be linked to an impaired pituitary activity.[5] But, as mentioned in the previous paragraph, T4 to T3 conversion is vital as well, with the net result of this decreased de-iodination with advancing age is a clear, age-dependent decline in total and free T3 levels...[2] ...
Age is the single greatest risk factor in the development of the blinding eye disease AMD where the prevalence of disease significantly increases as individuals enter their sixth decade. 2,3 In spite of this universal observation, other factors that lead to increased disease incidence remain undefined. Increases in damage from environmental stresses, accumulation of damaged proteins and organelles, and loss of function in important biochemical pathways all have been proposed. 3,4,13,52 The immune system is also thought to have a role in disease development 12-14,53 ; however, few studies have addressed how age-related changes in the immune response could be involved. The eye also is an immune privileged organ that can have a strong inhibitory influence on inflammatory and neovascular responses via a number of immunosuppressive mediators. 21 How age-dependent changes in the immune system are influenced by immune privilege and how age might alter the function of immune privilege is currently ...
In this report, we demonstrated that loss of function mutations in Popdc1 and Popdc2 genes in mice are associated with stress-induced SND, resulting in chronotropic incompetence and long sinus pauses. The Popdc genes displayed overlapping myocardial expression patterns and similar biochemical properties, and the cardiac phenotypes of the null mutants were nearly identical. Our data suggest that Popdc proteins represent a novel class of cAMP binding proteins that interact with TREK-1 channels and may be involved in channel trafficking. Age-dependent decline in cardiac pacemaking in Popdc null mutants. Both mouse mutants developed SND at advanced age. Assuming that Popdc genes act in the same pathway, loss of a single gene might not have a significant impact on function in the young, since both Popdc genes might be able to substitute for each other. Obviously, the compensation became less efficient when the null mutants aged, possibly due to an age-dependent decline of Popdc expression. ...
The diversity of the human TCR repertoire in aging has been studied by examining the profiles of complementarity-determining region 3 (CDR3) sizes expressed by the BV families. The TCRBV CDR3 profile, which shows size heterogeneity in young adult humans, is significantly restricted in aged humans. Clonal T cell expansions were identified using a PCR-based approach, in one or more BV families from all 14 healthy persons over the age of 65 that we studied. CD4+ T cell expansions were identified in 8 of 11 donors and CD8+ T cell expansions in 7 of 10 donors. These clonal expansions were stable during a 2-year period. Interestingly, more than half of the aged persons had clonal expansions within the BV3, -14, -16, and -23 families. Although there was no homology among the eight CDR3 sequences identified in clonal T cells from 8 aged persons, selective pressure on the expanded T cell clones was suggested by the fact that the BV families used by the T cell clones were not proportional to the number of ...
Immune aging may underlie various aging-related disorders, including diminished resistance to infection, chronic inflammatory disorders, and autoimmunity. PD-1+ and CD153+ CD44high CD4+ T cells with features of cellular senescence, termed senescence-associated T (SA-T) cells, increasingly accumulate with age and may play a role in the immune aging phenotype. In this article, we demonstrate that, compared with young mice, the aged mouse environment is highly permissive for spontaneous proliferation of transferred naive CD4+ T cells, and it drives their transition to PD-1+ and CD153+ CD44high CD4+ T cells after extensive cell divisions. CD4+ T cells with essentially the same features as SA-T cells in aged mice are also generated from naive CD4+ T cells after extensive cell divisions under severe T-lymphopenic conditions by gamma irradiation or in developmental T cell defect, often in association with spontaneous germinal centers, as seen in aged mice. The increase in SA-T cells is significantly enhanced
Geoffroy CG, Hilton BJ, Tetzlaff W, Zheng B How aging impacts axon regeneration after CNS injury is not known. We assessed the impact of age on axon regene …
TY - JOUR. T1 - Analysis of the age-related refractoriness of T-lymphocyte reactivity in humans. AU - Bátory, Gabriella. AU - Ónody, Clara. AU - Petrányi, G. Gy. PY - 1981/4. Y1 - 1981/4. N2 - Aged individuals could be divided into two groups according to their T-lymphocyte transformation values. The relationship between the PHA (phytohemagglutinin) stimulation indices and spontaneous thymidine incorporation; the PHA dose-response type distribution and the relative number of resting T lymphocytes was similar to the control group in aged subjects of seemingly intact T lymphocyte transformation values. However, their B cell compartment was found to be reduced. On the other hand, the ratio between the stimulation indices and spontaneous thymidine incorporation values of aged subjects of impaired T lymphocyte reactivity deviated from that of the control group. This group had an increased frequency of subjects giving maximal transformation values at relatively high PHA doses (hyposensitives) at ...
Cardiovascular System ✓ Gastrointestinal System ✓ Genitourinary System ✓ Musculoskeletal System ✓ Nervous System ✓ Sensory Changes ✓ Endocrine System ✓ Integum...
Umbilical cord blood from human newborns, and in particular a single protein contained in it, boosted old mices brain function and cognitive performance
The present study tested whether aging alters endotoxin-induced myocardial dysfunction in a sublethal model of endotoxemia in rats. The main findings were the following: 12 hours after LPS injection (0.5 mg/kg), a marked reduction in myocardial contractility was observed in the isolated perfused senescent heart; in contrast with septic cardiac dysfunction in young rats, myofilament Ca2+ sensitivity of left ventricular skinned fibers was not reduced in senescent rats; and NO production, oxidative stress, and antioxidant enzymes activities were not different between young adult and senescent LPS groups. Thus, despite similar alterations in potential mediators, cellular mechanisms responsible for this contractile dysfunction are different between young adult and senescent rats. More specifically, myofilament Ca2+ responsiveness remains unaltered in the senescent heart. This may have clinical implications for management of elderly septic patients.. Nonlethal models of endotoxemia have allowed ...
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First, we found that the level of soluble HS is positively correlated with age in vitreous samples from idiopathic maculopathies. We then showed that soluble HS levels in aqueous humor were lower in younger diabetic subjects with retinal NVs than in older diabetic subjects without retinal NVs or in nondiabetic subjects with cataract; the difference was no longer significant after controlling for the ages in these groups. The lack of correlation between severity of retinopathy and HS levels suggests that reduced HS levels in the aqueous humor in younger PDR patients could be explained at least in part by age and not by the severity of retinopathy. While the observation appears to contradict the reported correlation between reduced HS levels in the kidney and the diabetes mellitus [16-18], our study does not exclude the possibility of a less significant contribution of diabetes mellitus to ocular levels of HS. Analysis of the intraocular fluid from nondiabetic controls age-matched for PDR and a ...
Various age-related changes in the biomechanics and topography of different ocular components have been reported in the literature. Albon et al. (2000) observed a decrease in both the mechanical compliance and resilience of the human lamina cribrosa with age, and similar observations were made by Krag et al. (1997) in the lens capsule. Strong association was found between the age-related alterations in the optic nerve head and its increased susceptibility to glaucomatous damage (Burgoyne & Downs 2008). The asphericity of both the anterior and posterior corneal surfaces was reported to undergo significant changes with age, leading to a more spherical topography (Lam & Douthwaite 2002) and peripheral thinning (Dubbelman et al. 2006). Stiffening and increased tensile strength of the sclera were also found to be strongly associated with age (Avetisov et al. 1983; Schultz et al. 2008). Where an explanation was provided for these changes, it was the age-related increase in the intermolecular and ...
Evidence for age-dependent impairment of ovalbumin heterogeneous nuclear RNA (HnRNA) processing in hen oviduct.: The expression of the ovalbumin gene in hen ovi
Coenzyme Q10 supplementation reverses age-related impairments in spatial learning and lowers protein oxidation - Age (Dordr). 2013 Oct;35(5):1821-34 - the current study assessed the effect of CoQ intake in older mice for which cognitive and psychomotor impairments were already evident. Separate groups of young (3.5 months) and relatively old mice (17.5 months) were fed a control diet or a diet supplemented with low (0.72 mg/g) or high (2.81 mg/g) concentrations of CoQ for 15 weeks. After 6 weeks, the mice were given tests for spatial learning (Morris water maze), spontaneous locomotor activity, motor coordination, and startle reflex. Age-related impairments in cognitive and psychomotor functions were evident in the 17.5-month-old mice fed the control diet, and the low-CoQ diet failed to affect any aspect of the impaired performance. However, in the Morris water maze test, old mice on the high-CoQ diet swam to the safe platform with greater efficiency than the mice on the control diet. The old ...
This data collection contains data gathered in a longitudinal study of a sample of men aged 65 to 92 who were in good health during the first wave of the study in 1957. The chief aim of the study was to focus on the nature of the normal aging process in individuals of advanced age. The 47 study participants had not suffered from accidents, illnesses, severe emotional or personality problems, or environmental difficulties that might have led to premature aging, but 20 participants showed evidence of asymptomatic subclinical disease. This group represented the typical or average healthy aged individual with minimal degrees of physical pathology. Five years later, in 1962, a follow-up study was conducted with 29 of the 39 men still alive. The second follow-up, done in 1968, involved 19 of the surviving 23 men. The data are arranged in files by year: 1957, 1962, and 1968. Included are psychiatric data and medical evaluative data as well as various psychological and medical test scores (e.g., ...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
The effects of the co-agonist of the N-methyl-d-aspartate receptor (NMDAr) d-serine on glutamatergic neurotransmission and synaptic potentiation were studied in the CA1 hippocampal field of young (3-5 months old) and aged (25-27 months old) Sprague-Dawley rats using ex vivo extracellular electrophysiological recording techniques. Exogenous d-serine depressed fast neurotransmission mediated by the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid/kainate subtype of glutamate receptors in young but not in aged rats by acting on inhibitory glycinergic interneurons. In contrast, d-serine dose-dependently enhanced NMDAr-mediated synaptic responses in both groups of animals, but with a larger magnitude in aged rats, thus preventing the age-related decrease in NMDAr activation. d-serine also increased the magnitude of long-term potentiation in aged but not in young rats. Finally, d-serine levels were dramatically reduced in hippocampal tissues of aged rats. Taken together, these results indicate a ...
Background: Acute lung injury (ALI) is a significant source of morbidity and mortality in critically ill patients. Age is a major determinant of clinical outcome in ALI. The increased ALI-associated mortality in the older population suggests that there are age-dependent alterations in the responses to pulmonary challenge. The objective of this observational study was to evaluate age-dependent differences in the acute (within 6 hours) immunological and physiological responses of the heart and lung, to pulmonary challenge, that could result in increased severity. Methods: Male C57Bl/6 mice (young: 2-3 months, old: 18-20 months) were challenged intratracheally with cell wall components from Gram-positive bacteria (lipoteichoic acid and peptidoglycan). After 6 hours, both biochemical and physiological consequences of the challenge were assessed. Alveolar infiltration of inflammatory cells and protein, airspace and blood cytokines, cardiac function and myocardial proteasome activity were determined. Results:
Fatty acid (FA) uptake and/or intramuscular triglyceride (TG) accumulation in skeletal muscle are increased in obesity, type 2 diabetes and aging. FA translocase (FAT/CD36) translocation, lipin-1 subcellular localization and nuclear factor kappa B (NF-κB) p65 protein content in quadriceps muscle of …
2 Research Group Leaders in Ageing-related Diseases & Molecular Mechanisms of Ageing, with Institute of Molecular Biology gGmbH (IMB). Apply Today.
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Chair: Juulia Jylhävä. Markers of biological age have recently proven to be strong mortality predictors independent of other risk factors. As individuals with the same chronological age can vary substantially for their biological age it has become a pressing issue to find the determinants for biological age. This symposium presents findings on the genetic and environmental influences to the following markers of biological age: self-rated health, the frailty index, the epigenetic clock and telomere length. Using unique longitudinal twin cohorts with wide age ranges, we are also able to assess the changes in the contributing sources variation - i.e., genetics and shared and unique environments. The first paper demonstrates how the heritability of self-rated health is influenced by financial strain. The second paper examines if the polygenic risk scores for well-being are predictive of objective (i.e. frailty and multi-morbidity) and subjective indicators of age-related health (e.g. ...
Recent statistics indicate that the human population is ageing rapidly. Healthy, but also diseased, elderly people are increasing. This trend is particularly evident in Western countries, where healthier living conditions and better cures are available. To understand the process leading to age-associated alterations is, therefore, of the highest relevance for the development of new treatments for age-associated diseases, such as cancer, diabetes, Alzheimer and cardiovascular accidents. Mechanistically, it is well accepted that the accumulation of intracellular damage determined by reactive oxygen species (ROS) might orchestrate the progressive loss of control over biological homeostasis and the functional impairment typical of aged tissues. Here, we review how epigenetics takes part in the control of stress stimuli and the mechanisms of ageing physiology and physiopathology. Alteration of epigenetic enzyme activity, histone modifications and DNA-methylation is, in fact, typically associated with the
Recent statistics indicate that the human population is ageing rapidly. Healthy, but also diseased, elderly people are increasing. This trend is particularly evident in Western countries, where healthier living conditions and better cures are available. To understand the process leading to age-associated alterations is, therefore, of the highest relevance for the development of new treatments for age-associated diseases, such as cancer, diabetes, Alzheimer and cardiovascular accidents. Mechanistically, it is well accepted that the accumulation of intracellular damage determined by reactive oxygen species (ROS) might orchestrate the progressive loss of control over biological homeostasis and the functional impairment typical of aged tissues. Here, we review how epigenetics takes part in the control of stress stimuli and the mechanisms of ageing physiology and physiopathology. Alteration of epigenetic enzyme activity, histone modifications and DNA-methylation is, in fact, typically associated with the
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Aged rats (22 to 24 months) and young control rats (3 months) were tested in a battery of behavioral tests which included tests of learning, place navigation, sensorimotor integration, motor coordination, activity, and exploration. Following testing all animals were analyzed in an unanesthetized state for their local glucose utilization. Significant differences in glucose utilization were found between the aged and young groups on some behaviors and in some brain regions. There was considerable variability in the aged group in both their behavioral performance and their glucose utilization scores; thus, attempts were made to determine whether the variability in the degree of impairment within any particular behavioral test was correlated to the regional glucose utilization scores in any of the 45 brain regions analyzed. In two of the behavioral tests employed (i.e., one for learning and one for place navigation), the decline in performance correlated significantly with the decrement in regional ...
Matsuzawa, T and Cinader, B, Polymorphism of age-dependent changes in the production of a thf helper factor. (1982). Subject Strain Bibliography 1982. 2609 ...
Age-dependent changes in the exocytotic efficacy in Kir6.2 ablated mouse pancreatic β-cells. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
Reduced volume, or atrophy, in parts of the brain known as the amygdala and hippocampus may predict which cognitively healthy elderly people will develop dementia over a six-year period, according to a study.
Impaired energy production in older neurons may help explain why human brains are so vulnerable to age-related diseases, according to a new study at Salk Institute in California.. The scientists used a new strategy to discover that cells from older people had dysfunctional mitochondria - the power stations of cells - and lower energy production.. Mitochondria are responsible for converting our food into chemical energy our cells can use. Defects in mitochondrial genes can lead to disease, but researchers also know that mitochondria become less efficient with age and can drive age-related disorders, such as Alzheimers and Parkinsons.. Studying the impact of aging on mitochondria could help researchers gain a better understanding of the known link between mitochondrial dysfunction and age-related brain diseases.. The new findings are published in the journal Cell Reports.. Most other methods use chemical stresses on cells to simulate aging, said senior author Dr. Rusty Gage, a professor in ...
Elevated glucocorticoid levels produce hippocampal dysfunction and correlate with individual deficits in spatial learning in aged rats. Previously we related persistent cortisol increases to memory impairments in elderly humans studied over five years. Here we demonstrate that aged humans with signi …
Many detailed questions were formulated in order to provide a framework for discussing the crucial gaps in knowledge concerning CMV and immunosenescence. These included asking whether immunosenescence starts at the level of the hematopoietic stem cell (HSC); the role of the thymus? Which biomarkers are best? What impact does CMV have on the HSC microenvironment, thymus? Is there no age-associated decrease of CD8 naïve cells in CMV-negative people? Is the decrease in naïve cells in CMV+ people limited to CD8, and not CD4, cells? Is the decrease of naïve cells associated with any clinical outcome? Are T-regs altered with age and what is the effect of CMV thereon? Does CMV affect B cells (part of the IRP)? Is there a contribution of innate immunity to the IRP? What is the impact of CMV on cells bridging innate and adaptive immunity (Th17, Tγδ, NK, NKT, DC)? What is the relevance of telomere length measurements? Relevance of humoural factors, cytokines, such as type I IFN blocking telomerase; ...
Eosinophils surrounded by red blood cells (stock image). Credit: © Kateryna_Kon / Frailty and immune decline are two main features of old age.
The results of the present experiments establish that angiogenesis is impaired as a function of age. The reduced capability for collateral vessel development in response to ischemia was confirmed in 2 different animal models. The ultimate hindlimb BPR achieved at 40 days after surgery was significantly less in old than in young NZW rabbits. In old mice, perfusion of the ischemic hindlimb, reflected by the Doppler flow ratio, was significantly reduced compared with young mice; this difference was apparent as soon as 7 days after surgery and persisted throughout the duration (28 days) of the study. Likewise, the number of blood vessels that were angiographically visible in rabbits and the number of capillaries per unit area identified histologically in mice and rabbits were both significantly reduced in old versus young animals. The latter finding is consistent with the observation that myocardial angiogenesis related to left ventricular hypertrophy is attenuated in an age-dependent manner.20 The ...
Our results demonstrate that overexpression of mCAT protects mice from cardiac aging, providing direct evidence for the role of mitochondrial ROS in the aging of this vital organ. Several lines of evidence support this conclusion. In WT mice from the longevity cohort, we found age-dependent LV hypertrophy and a decline in cardiac performance (especially diastolic function), concomitant with the accumulation of oxidized mitochondrial proteins, mtDNA mutations, increased ventricular fibrosis, cardiomyocyte hypertrophy, a decline in SERCA2 protein, and activation of the calcineurin-NFAT pathway in the aged heart. These age-related alterations took place in the absence of significant cardiovascular risks such as diabetes, hypertension, or hypercholesterolemia, suggesting that these findings are primary changes of cardiac aging rather than secondary to other diseases. mCAT littermates were partially protected from all of the above age-related cardiac alterations, suggesting that these aging changes ...
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TY - JOUR. T1 - Calorie restriction initiated at middle age improved glucose tolerance without affecting age-related impairments of insulin signaling in rat skeletal muscle. AU - Park, Seongjoon. AU - Komatsu, Toshimitsu. AU - Hayashi, Hiroko. AU - Yamaza, Haruyoshi. AU - Chiba, Takuya. AU - Higami, Yoshikazu. AU - Kuramoto, Kazunao. AU - Shimokawa, Isao. PY - 2006/9. Y1 - 2006/9. N2 - Calorie restriction (CR) may affect glucose tolerance via modulation of the insulin action in skeletal muscle. The present study investigated the effect of CR initiated at middle age in rats bearing glucose intolerance, in comparison with CR at a younger age. Male F344 rats at 2.5 and 18 months (mo) of age were fed ad libitum (AL) or 30% CR diets for 4-4.5 mo, subjected to glucose tolerance testing, and then sacrificed 15 min after intraperitoneal glucose or saline injection to evaluate glucose-stimulated insulin response and subsequent activation of insulin signaling molecules. The protein abundance of ...
Skeletal muscle undergoes a progressive age-related loss in mass and function. Preservation of muscle mass depends in part on satellite cells, the resident stem cells of skeletal muscle. Reduced satellite cell function may contribute to the age-associated decrease in muscle mass. Here, we focused on characterizing the effect of age on satellite cell migration. We report that aged satellite cells migrate at less than half the speed of young cells. In addition, aged cells show abnormal membrane extension and retraction characteristics required for amoeboid-based cell migration. Aged satellite cells displayed low levels of integrin expression. By deploying a mathematical model approach to investigate mechanism of migration, we have found that young satellite cells move in a random memoryless manner, whereas old cells demonstrate superdiffusive tendencies. Most importantly, we show that nitric oxide, a key regulator of cell migration, reversed the loss in migration speed and reinstated the ...
TY - JOUR. T1 - Effect of whole-body vibration training on body composition, exercise performance and biochemical responses in middle-aged mice. AU - Lin, Ching I.. AU - Huang, Wen Ching. AU - Chen, Wen Chyuan. AU - Kan, Nai Wen. AU - Wei, Li. AU - Chiu, Yen Shuo. AU - Huang, Chi Chang. PY - 2015/9/1. Y1 - 2015/9/1. N2 - Aims Whole-body vibration (WBV) is a well-known light-resistance exercise by automatic adaptations to rapid and repeated oscillations from a vibrating platform, which is also a simple and convenient exercise for older adults. However, the potential benefits of WBV on aging-associated changes in body composition, exercise performance, and fatigue are currently unclear. The objective of the study is to investigate the beneficial effects of WBV training on body composition, exercise performance, and physical fatigue-related and biochemical responses in middle-aged mice. Methods In total, 24 male C57BL/6 mice aged 15 months old were randomly divided into 3 groups (n = 8 per group): ...
Sphingolipids have been implicated in age-related neurodegeneration. Previous studies have reported elevated ceramide levels in the brain of old rodents, but a systematic investigation of the impact of age on brain sphingolipid metabolism is still lacking. Here we quantified 17 key sphingolipid species in the hippocampus of young (3months), middle-aged (12months) and old (21months) male and female mice. Lipids were extracted and quantified by liquid chromatography/mass spectrometry; transcription of enzymes involved in sphingolipid biosynthesis was evaluated by qPCR. Age-dependent changes of multiple sphingolipid species - including ceramide (d18:1/18:0), sphingomyelin (d34:1), hexosylceramide (d18:1/16:0), ceramide (d18:1/24:0) - were found in mice of both sexes. Moreover, sex-dependent changes were seen with hexosylceramide (d18:1/18:0), ceramide (d18:1/22:0), sphingomyelin (d36:1) and sphingomyelin (d42:1). Importantly, an age-dependent accumulation of sphingolipids containing nervonic acid ...
Kubo KY, Kotachi M, Suzuki A, Iinuma M, Azuma K.. Chewing during prenatal stress prevents prenatal stress-induced suppression of neurogenesis, anxiety-like behavior and learning deficits in mouse offspring.. Int J Med Sci 15:849-58, 2018. Azuma K, Zhou Q, Kubo KY.. Morphological and molecular characterization of the senile osteoporosis in senescence-accelerated mouse prone 6 (SAMP6).. Med Mol Morphol 51:139-146, 2018. Azuma K, Toyama T, Katano M, Kajimoto K, Hayashi S, Suzuki A, Tsugane H, Iinuma M, Kubo KY.. Yokukansan ameliorates hippocampus-dependent learning impairment in senescence-accelerated mouse.. Biol Pharm Bull.41:1593-1599, 2018. Kizaki K, Uchida S, Yamashita F, Tsukamoto M, Azuma K.. Microstructure of osteophytes in medial knee osteoarthritis.. Clin Rheumatol. 37:2893-2896, 2018. Tsukamoto M, Wang KY, Tasaki T, Murata Y, Okada Y, Yamanaka Y, Nakamura E, Yamada S, Izumi H, Zhou Q, Azuma K, Sasaguri Y, Kohno K, Sakai A.. Findings as a starting point to unravel the underlying ...
1. Targonski P.V, Jacobson R.M, Poland G.A. Immunosenescence: role and measurement in influenza vaccine response among the elderly. Vaccine. 2007;25:3066-3069 2. Noreddin A.M, Haynes V. Use of pharmacodynamic principles to optimise dosage regimens for antibacterial agents in the elderly. Drugs Aging. 2007;24:275-292 3. Liang S.Y, Mackowiak P.A. Infections in the elderly. Clin Geriatr Med. 2007;23:441-456 4. Vasto S, Candore G, Balistreri C.R, Caruso M, Colonna-Romano G. et al. Inflammatory networks in ageing, age-related diseases and longevity. Mech Ageing Dev. 2007;128:83-91 5. High K.P, Prasad R, Marion C.R, Schurig G.G, Boyle S.M. et al. Outcome and immune responses after Brucella abortus infection in young adult and aged mice. Biogerontology. 2007;8:583-593 6. Htwe T.H, Mushtaq A, Robinson S.B, Rosher R.B, Khardori N. Infection in the elderly. Infect Dis Clin North Am. 2007;21:711-743 7. Hakim F.T, Gress R.E. Immunosenescence: deficits in adaptive immunity in the elderly. Tissue Antigens. ...
Food-grade diatomaceous earth possesses a number of anti-aging benefits. These anti-aging benefits include improvement in skin elasticity, softening of wrinkles and fine lines, and preventing the onset of age-related disorders, such as memory loss i.e. dementia and bone problems like osteoporosis. Lets take a look at how diatomaceous earth works to prevent the occurrence of osteoporosis in aged individuals. Role of Diatomaceous In Preventing Osteoporosis. Diatomaceous earth bloggers have said that it has a scientifically-proven role in maintaining the bone density and helping in overall bone formation. Its mostly beneficial in aged individuals who tend to go through age-related degeneration of bones. When a person ages, their total number of osteoclasts i.e. cells which are responsible for destruction of bone-cell tissues is much higher as compared to osteoblasts i.e. cells which are involved in integral bone formation because of their protein and minerals transport activity. This imbalance in ...
The molecular mechanisms by which heterogeneity, a major characteristic of stem cells, is achieved are yet unclear. We here study the expression of the membrane stem cell antigen-1 (Sca-1) in mouse bone marrow Mesenchymal Stem Cell (MSC) clones. We show that subpopulations with varying Sca-1 expression profiles regenerate the Sca-1 profile of the mother population within a few days. However, after extensive replication in vitro the expression profiles shift to lower values and the regeneration time increases. Study of the promoter of Ly6a unravels that the expression level of Sca-1 is related to the promoter occupancy by the activating histone mark H3K4me3. We demonstrate that these findings can be consistently explained by a computational model that considers positive feedback between promoter H3K4me3 modification and gene transcription. This feedback implicates bistable epigenetic states which the cells occupy with an age-dependent frequency due to persistent histone (de-)modification. Our ...
TY - JOUR. T1 - The role of estrogen in the development of age-related cognitive impairment and dementia. AU - Dumas, Julie. AU - Salerno, Jessica. AU - Newhouse, Paul. PY - 2006/4/1. Y1 - 2006/4/1. N2 - While evidence is conflicting, estrogen cannot be recommended for the treatment of dementia but may have a role in preserving cognitive functioning in older women. Estrogen may have a dementia-prevention effect after menopause based on epidemiologic studies (not primary prevention studies), but this is not an approved indication. At this point, the off-label prescribing of estrogen for cognitive decline in the absence of dementia is not a routine clinical practice and should be regarded as appropriate only within the context of a research study. Estrogen may be used in late-stage dementia to treat aggressive or sexually disinhibited behavior,45 but this would not be considered a routine use in dementia patients. Estrogen use after menopause has been linked to increased risk of venous thrombosis, ...
Introduction: Previous studies have shown significant age-related change in the first-order kernel response of the multifocal ERG (mfERG). However, they all involved use of ring averages across the retinal field. Purpose: To estimate the age-related changes in the localized response and retinal topography using point-to-point comparison. To determine the localized variability in the mfERG scalar product across age and the topography of the age-related change. Methods: MfERG recordings of 71 normal phakic subjects (ages 9-80) were analyzed with VERIS TM 4.8. The stimulus parameters were: 103 hexagons, 75 Hz frame rate, peak luminance 200 cd/m2, m= 2^14. Scalar products (for each hexagon based on ring average templates) were obtained and analyzed for age-related changes. Statistical measures (coefficient of variation (CV) and parameters of a linear regression model) were applied. Point-by-point comparison for hemifields was performed. Results: Each localized response showed a significant aging ...
TY - JOUR. T1 - Age-related effect of cells-donors of nuclei on efficiency of development of cloned rabbit embryos. AU - Lagutina, I. S.. AU - Mezina, M. N.. AU - Prokofev, M. I.. AU - Chernykh, V. Ya. AU - Galat, V. V.. PY - 2001/12/1. Y1 - 2001/12/1. N2 - We studied the capacity of nuclei of rabbit fibroblasts taken from various developmental stages for reprogramming in the cytoplasm of mature aging enucleated oocytes and development of the cloned embryos to the preimplantation stages. A negative correlation was found between the age of an animal-donor of fibroblasts and efficiency of the development of cloned embryos (rmorula-blastocyst = -0.826, rblastocyst = -0.7139). A reliably decreased capacity for reprogramming of the nuclei of donor fibroblasts was shown upon transition from prenatal development to the postnatal one, as well as a trend to a decreased capacity of nuclei for reprogramming during aging. Aging of cells in the culture, at least until the 10th passage, did not affect the ...
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Non-enzymatic protein modifications occur inevitably in all living systems. Products of such modifications accumulate during aging of cells and organisms and may contribute to their age-related functional deterioration. This review presents the formation of irreversible protein modifications such as carbonylation, nitration and chlorination, modifications by 4-hydroxynonenal, removal of modified proteins and accumulation of these protein modifications during aging of humans and model organisms, and their enhanced accumulation in age-related brain diseases.
Healthy aging has been shown to modulate the neural circuitry underlying simple declarative memory; however, the functional impact of negative stimulus valence on these changes has not been fully investigated. Using BOLD fMRI, we explored the effects
PURPOSE: Little research has analyzed mistrust and discrimination influencing receipt of health care services among Latinos, particularly those living in rural areas. The present study examined the associations between medical mistrust, perceived discrimination, and satisfaction with health care among young-adult rural Latinos. RESEARCH DESIGN: This cross-sectional study analyzed data from 387 young-adult Latinos (ages 18-25) living in rural Oregon. The Behavioral Model of Vulnerable Populations was utilized as the theoretical framework. Correlations were run to assess bivariate associations among variables included in the study. Ordered logistic regression models evaluated the associations between medical mistrust, perceived discrimination, and satisfaction with health care. RESULTS: On average, participants used health services 4 times in the past year. Almost half of the participants had health insurance (46%). The majority reported that they were moderately (32%) or very satisfied (41%) with ...
We investigated the influences of short-term and lifespan-prolonging long-term caloric restriction (LCR) on gene expression in white adipose tissue (WAT). Over 11,000 genes were examined using high-density oligonucleotide microarrays in four groups of 10- to 11-month-old male C57Bl6 mice that were either fasted for 18 h before death (F), subjected to short-term caloric restriction for 23 days (SCR), or LCR for 9 months and compared with nonfasted control (CO) mice. Only a few transcripts of F and SCR were differentially expressed compared with CO mice.
As we age and get older our immune system starts to decline in strength and isnt as vigorous as it once was. Because of this Life Extension Immune Senescence Protection Formula has been invented. This formula helps support and strengthens your immune
The first half of the module will explore age related changes in cognitive and moral development from early infancy to late adolescence. It will also consider the other major changes that occur in adolescence including social, biological, and neurological changes and how this might impact on normative development in this sensitive period. The second half will deal with health ageing in comparison to age-related disorders such as mild cognitive impairment and dementia. These issues will be considered in terms of brain anatomy and function as well as the effect on the individual and society. Current methods in ageing and developmental research will also be discussed.. ...
TY - JOUR. T1 - Comparative pharmacokinetics of three doses of percutaneous dihydrotestosterone gel in healthy elderly men - A clinical research center study. AU - Wang, C.. AU - Iranmanesh, A.. AU - Berman, N.. AU - Mcdonald, V.. AU - Steiner, B.. AU - Ziel, F.. AU - Faulkner, S. M.. AU - Dudley, R. E.. AU - Veldhuis, J. D.. AU - Swerdloff, R. S.. PY - 1998/11/10. Y1 - 1998/11/10. N2 - Twenty-five men, 60-80 yr old, participated in a pharmacokinetic study to compare three doses (16, 32, and 64 rag/day, n = 8 or 9 in each group) of 5α-dihydrotestosterone (DHT) gel (0.7% hydroalcoholic gel with 2.3 g gel delivering 16 mg DHT) applied daily over one upper arm (16 mg); both arms and shoulders (32 mg); and bilateral arms, shoulders, and upper abdomen (64 mg), respectively. Multiple blood samples for the pharmacokinetic profile for DHT and testosterone (T) were drawn over a 24-h period before application, after first application, and after 14 days of daily application of DHT gel. Additional blood ...
Researchers at Columbia University Medical Center reversed age-related memory loss in mice by boosting blood levels of osteocalcin, a hormone produced by bone cells.
Elderly men with low levels of testosterone or other sex hormones have twice the likelihood of having declining physical function over two years time compared with their peers who have the highest hormone levels, a new study from Australia finds. The results will be presented Saturday at the joint meeting of the International Society of Endocrinology and the Endocrine Society: ICE/ENDO 2014 in Chicago.
The individual and combined effects of cimetidine and ciprofloxacin on theophylline metabolism were examined in healthy young and elderly male and female nonsmokers. Single-dose studies of theophylline pharmacokinetics were performed at base line and on the fifth day of each of three treatment regimens consisting of 400 mg cimetidine every 12 hr, 500 mg ciprofloxacin every 12 hr and the combination of cimetidine and ciprofloxacin. Base-line theophylline plasma clearance and formation clearance of theophylline metabolites decreased with age in both gender groups to a similar extent (20% less in elderly men than in young men; 24% less in elderly women than in young women). Individually, cimetidine and ciprofloxacin produced proportionate declines in plasma theophylline clearance that were similar among the four groups (range, 23.4-32.7% decrease). The combined regimen yielded further impairment in theophylline elimination compared with each agent alone (range, 35.9-42.6% decrease). Cimetidine was ...
Inflammaging and immune senescence mini-review, a new area of research studying the changes in the immune system that occur as people age. Using flow cytometry, the pathological characteristics of aging tissues across multiple species can be identified.
Aging stem cells may play a critical role in determining the effects of aging on organ function. With regard to vascular diseases, it has been postulated that circulating EPCs are involved in the repair mechanisms after endothelial damage (27,28). Ultimately, deterioration of endothelial or vascular function may be related to both quantitative and qualitative changes of stem cells.. We describe here the first comprehensive analysis of the association between age-related endothelial dysfunction and the number and function of circulating EPCs, defined by expression of CD34+/VEGFR2+ and CD133+/VEGFR2+. Although no quantitative differences in EPCs were observed, our data illustrate that culture-enriched EPCs from old but otherwise healthy subjects are impaired in terms of fundamental functional features like proliferation (important for amplifying the cellular pool), migration (critical for homing of circulating EPCs), and survival. We demonstrate a significant univariate correlation between the ...
Deficiency of the fast-twitch muscle protein alpha-actinin-3 due to homozygosity for a nonsense polymorphism (R577X) in the ACTN3 gene is common in humans. alpha-Actinin-3 deficiency (XX) is associated with reduced muscle strength/power and enhanced endurance performance in elite athletes and in the general population. The association between R577X and loss in muscle mass and function (sarcopenia) has previously been investigated in a number of studies in elderly humans. The majority of studies report loss of ACTN3 genotype association with muscle traits in the elderly, however, there is some indication that the XX genotype may be associated with faster muscle function decline. To further explore these potential age-related effects and the underlying mechanisms, we examined the effect of alpha-actinin-3 deficiency in aging male and female Actn3 knockout (KO) mice (2, 6, 12, and 18 months). Our findings support previous reports of a diminished influence of ACTN3 genotype on muscle performance in the
Age-related gene response of human corneal endothelium to oxidative stress and DNA damage. Invest Ophthalmol Vis Sci. 2011 Mar 01; 52(3):1641-9 ...
ABSTRACTInsulin-like growth factor-I (IGF-I) clearly plays a role in bone metabolism and maintenance, as evidenced by in vitro and animal studies. In clinical studies, the age-related decrease in IGF-I parallels the age-related decrease in bone mineral density (BMD), but several age-adjusted cross-s
TY - JOUR. T1 - Age-related increase of airway neutrophils in older healthy nonsmoking subjects. AU - Pignatti, Patrizia. AU - Ragnoli, Beatrice. AU - Radaeli, Alessandro. AU - Moscato, Gianna. AU - Malerba, Mario. PY - 2011/8/1. Y1 - 2011/8/1. N2 - Background: Although an influence of advancing age on lung cellularity in healthy subjects has already been described, induced sputum reference values for cell counts in older healthy adults are not available. The aim of the present study was to evaluate the influence of age on the variation of sputum cell distribution in a considerable number of healthy subjects. A total of 70 nonatopic, nonsmoker healthy subjects aged ≥50 years underwent sputum induction and blood cell count. Sputum samples were processed and then were analyzed by optical microscopy. Differential cell counts were reported as percentages and amount of cells/mg. Results: Sputum cell distribution of healthy subjects aged ≥50 years was mainly composed of neutrophils. Both the ...
Immunosenescence refers to the gradual deterioration of the immune system brought on by natural age advancement. It involves both the hosts capacity to respond to infections and the development of long-term immune memory, especially by vaccination. This age-associated immune deficiency is ubiquitous and found in both long- and short-living species as a function of their age relative to life expectancy rather than chronological time. It is considered a major contributory factor to the increased frequency of morbidity and mortality among the elderly. Immunosenescence is not a random deteriorative phenomenon, rather it appears to inversely repeat an evolutionary pattern and most of the parameters affected by immunosenescence appear to be under genetic control. Immunosenescence can also be sometimes envisaged as the result of the continuous challenge of the unavoidable exposure to a variety of antigens such as viruses and bacteria. Immunosenescence is a multifactorial condition leading to many ...
The incidence of VTE is significantly lower in children compared with adults, suggesting the presence of protective mechanisms [11]. In children, the coagulation system develops with age, as evidenced by significant age-related differences in the concentration of most clotting factors, a concept known as developmental hemostasis [11].. In a nationwide epidemiologic study in the Korean population, the annual incidence of VTE in 2008 was reported as 13.8 cases per 100,000 individuals [12], which is significantly lower than the annual incidence noted for the Caucasian population (143 cases per 100,000 individuals) [13]. Furthermore, the incidence of VTE in Korean youth was even lower, with a reported 0.09 cases per 10,000 individuals aged 0-19 years [12].. In our study, the incidence of VTE was 3.27 cases per 10,000 pediatric patients. This rate was higher than the previously reported VTE incidence in the general Korean pediatric population but was lower than the incidence reported from Western ...
Alzheimers disease (Advertisement) can be an age-associated disease seen as a increased build up of extracellular -amyloid (A) plaques within the mind. a crucial developmental period at six months where cells remain in a position MK-2866 to connect to A fibrils but drop their capability to phagocytose it. and so are maintained inside a basally reactive phenotype [31C33]. Consequently, adult microglia instead of early postnatal microglia may provide a even more relevant model for determining the complete microglia-A conversation during disease. Many studies have recorded that acutely isolated adult microglia from rodent brains maintain a quiescent phenotype although long term culturing ultimately prospects to activation [23, 34C38]. To be able to better define whether an age-dependent switch in microglial A conversation is present, microglia acutely isolated from differing age group C57BL/6 mouse brains had been utilized to examine not merely degrees of putative A receptors, but moreover, ...
As PS1 is an integral protein of the γ-secretase complex, its stoichiometry may play an important role in balanced processing of APP. A decrease in PS1 (Refolo et al., 1999) or inactivation by mutations (Sudoh et al., 1998) may be associated with increased Aβ42. We had previously noticed an increase in APP as well as Aβ1-42 with age in SAMP8 mice (Morley et al., 2000), suggesting that a decrease in PS1 may cause increased aberrantγ -secretase activity. Accumulation of Aβ is attributed to loss of memory, as reduction of APP expression reverses this loss (Kumar et al., 2000). Therefore, reduction in APP expression is one of the pharmaceutical approaches to counter age-dependent or neurodegenerative disorders like AD that involve memory loss. Being an essential component of γ-secretase, PS1 is another therapeutic target for reducing Aβ formation. As SAMP8 mice have been shown to exhibit memory loss at a relatively early age (Flood and Morley, 1998; Miyamoto, 1997), we have studied the ...
As shown in Table 1, at 9 months of age, we observed a decline in GFR and renal plasma flow in the animals which ingested the lipid-rich diets, and in 18-month-old rats, the fish oil and butter groups showed a significant decrease in those parameters when compared to the control group at the same age; if corrected for kidney weight, these differences were still present; for example, GFR was 1.95 ± 0.11 in controls, 0.95 ± 0.04 in the butter group, 1.04 ± 0.17 in the fish oil group and 1.33 ± 0.29 ml min-1 g-1 in the canola oil group, confirming that the age-dependent decline in renal function was accelerated by the ingestion of LD. The complex mechanism by which lipids aggravate renal diseases is not well understood. Factors such as intraglomerular macrophage infiltration, increased glomerular capillary pressure and the degree of lipoprotein oxidation have been claimed to be major determinants of the progression of glomerulosclerosis (5-7). However, the controversy about the effects of ...
The present invention is a method for analyzing the biological age of a subject. The method analyzes the biological age as it relates to a number of factors indicating levels of health, energy production and metabolism. The method may also be used to calculate a subjects biological age and treat the factors associated with biological age.
With extension of the average lifespan, the ageing population has become a heavy burden for both society and individuals. Immune responses, key for the removal of pathogens and damage, are compromised in the elderly, making the elderly more susceptible to infections. In addition immune senescence is a risk factor for many late-onset diseases, such as cancer and atherosclerosis. Autophagy through degrading bulk cytoplasmic material maintains cytoplasmic health and cellular homeostasis [1]. We have found that it allows differentiation of immune cells [2] [3]. In previous work we showed that loss of autophagy in macrophages results in low-grade inflammation (inflamm-aging) and reduces innate and adaptive immune responses, typical of a senescent immune system. Autophagy induction rejuvenates immune responses in the elderly in T cells [3]. We have recently uncovered a novel pathway that controls the translation of autophagy proteins in T and B lymphocytes. Lymphocytes from old mice and elderly humans ...
This two-part study is assessing the pharmacokinetics and effects on age-related cognitive decline of GSK-2981710 (medium chain triglycerides) in elderly Po-Hsiang Liao, Dennis Jine-Yuan Hsieh, Chia-Hua Kuo, Cecilia-Hsuan Day, Chia-Yao Shen, Chao-Hung Lai, Ray-Jade Chen, V. Vijaya Padma, Wei- Wen Kuo,...
Molecular Cardiology, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MADepartment of Orthopedic Surgery, Brigham and Womens Hospital, Harvard Medical School, Boston, MA ...
Background With increasing age neuromuscular deficits (e.g., sarcopenia) may result in impaired physical performance and an increased risk for falls. Prominent intrinsic fall-risk factors are age-related decreases in balance and strength / power performance as well as cognitive decline. Additional studies are needed to develop specifically tailored exercise programs for older adults that can easily be implemented into clinical practice. Thus, the objective of the present trial is to assess the effects of a fall prevention program that was developed by an interdisciplinary expert panel on measures of balance, strength / power, body composition, cognition, psychosocial well-being, and falls self-efficacy in healthy older adults. Additionally, the time-related effects of detraining are tested.. Methods/Design Healthy old people (N = 66) between the age of 65 to 80 years will participate in this trial. The testing protocol comprises tests for the assessment of static / dynamic steady-state balance ...
What is it? The aging eye can be affected in many different ways. One of them being the formation of a cataract or clouding of the normal human crystalline lens. The other common age related change affecting the eye is called age related macular degeneration (AMD). This condition usually affects people in the 6th or 7th decade of life, but may occur in the younger population.. This condition affects the area at the back of the eye, responsible for the central part of the vision, the macula (see Eye anatomy). Degeneration, or breakdown of this part of the retina causes loss of central vision, and is one of the most common causes of legal blindness in South Africa, and the world. Most patients retain some form of peripheral vision, but overall prognosis in late / advanced AMD can be very poor.. What is DRY and WET AMD? Dry AMD is the more common form and is also referred to as atrophic or non-exudative AMD. There is formation of drusen beneath the macula that build up and eventually causes ...
The aim of this doctoral thesis was to investigate and to understand the implication of oxidative stress, created by the interplay of ionizing (X-ray) radiation, oxygen and neurotoxic amyloid beta (Aβ) peptide, in age-associated diseases, with the focus on Alzheimer´s disease (AD), the most common dementia. Although AD has been known for more than hundred years, its mechanisms are still intriguing and there is no cure at the moment. High doses of ionizing radiation (IR) lead to learning and memory impairment which is characteristic for AD as well. The cumulative doses of IR used in medical imaging procedures such as computed tomography (CT) and dental X-rays present a potential danger, particularly to children whose brains are not completely developed. Although single doses of radiation used for diagnostic purposes or therapeutic treatment are relatively low, small changes on the molecular and cellular level may accumulate upon repeated exposure and result in delayed long-term defects. Thus, ...
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Authors: Stepanichev, Mikhail , Onufriev, Mikhail , Aniol, Viktor , Freiman, Sofia , Brandstaetter, Hemma , Winter, Stefan , Lazareva, Natalia , Guekht, Alla , Gulyaeva, Natalia Article Type: Research Article Abstract: Background: Aging is associated with some cognitive decline and enhanced risk of development of neurodegenerative diseases. It is assumed that altered metabolism and functions of neurotrophin systems may underlie these age-related functional and structural modifications. CerebrolysinTM (CBL) is a neuropeptide mixture with neurotrophic effects, which is widely used for the treatment of stroke and traumatic brain injury patients. It is also evident that CBL has an overall beneficial effect and a favorable benefit-risk ratio in patients with dementia. However, the effects of CBL on cognition and brain neurotrophin system in normal aging remain obscure. Objective: The aim …of the present study was to examine the age-related modifications of endogenous neurotrophin systems in the ...
TY - CHAP. T1 - Aging-associated alterations in myocardial inflammation and fibrosis. T2 - Pathophysiological perspectives and clinical implications. AU - Shinde, Arti V.. AU - Frangogiannis, Nikolaos G.. PY - 2014/1/1. Y1 - 2014/1/1. N2 - Senescent hearts exhibit structural and molecular changes that result in impaired function and are associated with diminished ability to meet increased demand. Both animal model studies and clinical investigations suggest that fibrosis is a hallmark of cardiac aging. Expansion of the cardiac interstitium and accumulation of collagen in the aging heart cause a progressive increase in ventricular stiffness, contributing to impaired diastolic function. Increased mechanical load due to increased vascular stiffness and direct activation of senescence-associated fibrogenic signals in the myocardium are implicated in the pathogenesis of cardiac fibrosis in the elderly. Reactive oxygen species (ROS), chemokine-mediated recruitment of mononuclear cells and fibroblast ...
TY - CHAP. T1 - Effect of aging on changes of nociception and Cav2α1 expression patterns in seven inbred mouse strains. AU - Takahashi, Eiki. PY - 2012/8. Y1 - 2012/8. N2 - The depolarization induced by Cav2 decreases and pain threshold increases with aging. To characterize strain dependence of age-related changes in nociception and spinal expression of Cav2 in mice, we evaluated nociceptive sensitivity and Cav2α1 mRNA expression in 2-month-old and 20-month-old mice of seven inbred strains (A/J, AKR/N, BALB/c, C3H/HeJ, C57BL6/J, DBA/2, 129/SvJ). In the hot plate test, 20-month-old C3H/HeJ showed reduced thermal nociceptive thresholds relative to 2-month-old mice, but no difference was observed between 2-month-old and 20-month-old mice of other strains. In the formalin paw test, there was no difference in licking/biting time in phase 1 between 2-month-old and 20-month-old animals of any strain, but the phase 2 responses in 20-month-old C3H/HeJ and DBA/2 were decreased compared with those of ...
Analysis of mitochondrial function in tissues, such as the skeletal muscle of older subjects, reveals a decline in mitochondrial respiratory capacity to roughly 50% of what is seen in younger subjects and a reduction in ATP (63, 64). These mitochondrial deficits track closely with functional decline in muscle strength and are believed by most to be a causal factor for age-related sarcopenia (65). While, as mentioned above, in certain rare cases, accumulation of mtDNA mutations might contribute to this functional deficit, it is likely that other mechanisms are at play. An increase in the steady-state levels of dysfunction could be due to an increase in age-dependent damage to mitochondria, an age-dependent decline in the removal of dysfunctional mitochondria, or some combination of both mechanisms. The removal of damaged but intact mitochondria occurs through the process of mitophagy. We have already briefly discussed this process in the setting of inflammasome activation, where mitophagy, by ...
Middle Ages[edit]. A manuscript of Al-Risalah al-Dhahabiah by Ali al-Ridha, the eighth Imam of Shia Muslims. The text says: " ... After the fall of the Western Roman Empire and the onset of the Early Middle Ages, the Greek tradition of medicine went into ... During the Middle Ages, the Catholic Church established universities which revived the study of sciences - drawing on the ... In China, archaeological evidence of medicine in Chinese dates back to the Bronze Age Shang Dynasty, based on seeds for ...
1967 Age Discrimination in Employment Act[edit]. The Age Discrimination in Employment Act (ADEA) of 1967 prohibited employment ... Some older workers were being denied health benefits based on their age and denied training opportunities prior to the passage ... Children under eighteen cannot do certain dangerous jobs, and children under the age of sixteen cannot work during school hours ... to allow an employer to pay less than the minimum wage to individuals whose earning or productive capacity is impaired by age, ...
Current records by age-group[edit]. Age group. Male record. Distance (KM). Female record [86]. Distance (KM) ... Age 30-34 Date Rider Age Velodrome Distance (km) Supported by Equipment Notes ... Age 35-39 Date Rider Age Velodrome Distance (km) Supported by Equipment Notes ... Age 40-44 Date Rider Age Velodrome Distance (km) Supported by Equipment Notes ...
Spirituality, New Age, and new religions[edit]. Brahma Kumaris[edit]. In Brahma Kumaris, human souls are believed to be ... 2009). Superstition: Belief in the Age of Science. Princeton University Press. p. 90. ISBN 978-0-691-13355-3 ... 2009). Superstition: Belief in the Age of Science. Princeton University Press. ISBN 978-0-691-13355-3 ...
Electronic age[edit]. The global village[edit]. In the early 1960s, McLuhan wrote that the visual, individualistic print ... Electronic age. For the break between the time periods in each case the occurrence of a new medium is responsible, the hand- ... So language was the last art to accept the visual logic of Gutenberg technology, and the first to rebound in the electric age.[ ... In this new age, humankind will move from individualism and fragmentation to a collective identity, with a "tribal base." ...
As age increases, age-related observational learning motor skills may decrease in athletes and golfers.[14] Younger and skilled ... Age difference[edit]. Albert Bandura stressed that developing children learn from different social models, meaning that no two ... For example, girls aged 11 to 14 performed better on a motor performance task when they thought it was demonstrated by a high- ... Children aged 6 to 8 in an indigenous heritage community in Guadalajara, Mexico participated in hard work, such as cooking or ...
Chemotherapy and aging[edit]. In aged and chemotherapy treated females, oocytes and follicles are depleted by apoptosis ( ... DNA damage-induced oocyte apoptosis depends on the efficiency of the DNA repair machinery that in turn declines with age. ... Survival of oocytes following chemotherapy or aging can be enhanced by increased expression of Rad51.[35] The Rad51-induced ... "Enhancing survival of mouse oocytes following chemotherapy or aging by targeting Bax and Rad51". PLoS ONE. 5 (2): e9204. doi ...
The smell of aged pu'erh may vary, with an "aged" but not "stuffy" odor. The taste of aged raw pu'erh or ripe pu'erh should be ... Because of its ability to age without losing "quality", well aged good pu'er gains value over time in the same way that aged ... Bǐngchá and zhuancha thus age more quickly than golden melon, tuocha, or jincha. Larger bingcha age slower than smaller ' ... Aging and storage[edit]. Pu'er teas of all varieties, shapes, and cultivation can be aged to improve their flavor, but the ...
Aging[edit]. BDNF levels appear to be highly regulated throughout the lifetime both in the early developmental stages and in ... Although BDNF is needed in the developmental stages, BDNF levels have been shown to decrease in tissues with aging.[90] Studies ... Tapia-Arancibia L, Aliaga E, Silhol M, Arancibia S (November 2008). "New insights into brain BDNF function in normal aging and ... it does suggest there is a relationship that might explain some of the cognitive decline that occurs during aging. ...
Age[edit]. Age is the strongest reason for olfactory decline in healthy adults, having even greater impact than does cigarette ... 2% of people under 65 years of age have chronic smelling problems. This increases greatly between people of ages 65 and 80 with ... Prevalence rose from 4.2% at age 40-49 to 39.4% at 80 years and older and was higher in men than women, in blacks and Mexican ... Age-related changes in smell function often go unnoticed and smell ability is rarely tested clinically unlike hearing and ...
Age of onset[edit]. ALS can also be classified based on the age of onset. While the peak age of onset is 58 to 63 for sporadic ... The disease can affect people of any age, but usually starts around the age of 60 and in inherited cases around the age of 50.[ ... the lowest prevalence was in the 18-39 age group, while the highest prevalence was in the 70-79 age group.[18] Sporadic ALS ... "Aging and Disease. 4 (5): 295-310. doi:10.14336/AD.2013.0400295. PMC 3794725. PMID 24124634.. ...
Developmental age[edit]. Fehr, Bernhard, and Rockenbach (2008), in a study conducted on children, found that boys displayed in- ... Thus males tended to show in-group biases from a younger age than females, as was evident in the experiment.[29] ... group favouritism from ages 3-8, whereas girls did not display such tendencies.[29] The experiment involved usage of an "envy ...
Insulation aging[edit]. R-values of products may deteriorate over time. For instance the compaction of loose fill cellulose ... However, the LTTR effectively provides only an eight-year aged R-value, short in the scale of a building that may have a ... There are other foams which do not change significantly with aging because they are blown with water or are open-cell and ... Foil-faced polyisocyanurate rigid panel (pentane expanded) aged 5-10 years 0.97. R-5.5. 38 ...
a b Hegermann, Harald (2008) "The Diaspora in the Hellenistic Age." In: The Cambridge History of Judaism, Vol. 2. Eds.: Davies ... Kleiner, Fred (2010). Gardner's Art Through the Ages: A Global History, Enhanced, Volume I: 1. Wadsworth Publishing. p. 262. ... Middle Ages. Ashkenazi Jews. Ashkenazi Jews is a general category of Jewish populations who immigrated to what is now Germany ... Antonia Tripolitis (2002). Religions of the Hellenistic-Roman Age. Wm. B. Eerdmans Publishing. pp. 61-62. ISBN 9780802849137.. ...
A famous student of this age was Joseph-Louis Lagrange. Age of Victor Emmanuel I (1817-1832)[edit]. ...
Middle Ages[edit]. Charlton is assessed in the Domesday Book of 1086 at one "sulung", which is commonly held to have been the ... 42.95 of people in the ward were aged 20-44.[27] ...
Middle Ages[edit]. The oldest mention of the city appears in a cartulary, Bayonne's Golden book, from 1186, where it is named ... From the Middle Ages and Early modern period a watchtower has looked down over the sea at Biarritz, from "La Humade", waiting ... Two population centers are attested in the Middle Ages. On the one hand, the église Saint-Martin was active in the ...
Tuohimaa P (March 2009). "Vitamin D and aging". The Journal of Steroid Biochemistry and Molecular Biology. 114 (1-2): 78-84. ... Premature aging[edit]. Complex regulatory mechanisms control metabolism. Recent epidemiologic evidence suggests that there is a ... Keisala T, Minasyan A, Lou YR, Zou J, Kalueff AV, Pyykkö I, Tuohimaa P (July 2009). "Premature aging in vitamin D receptor ... Tuohimaa P, Keisala T, Minasyan A, Cachat J, Kalueff A (December 2009). "Vitamin D, nervous system and aging". ...
Old trees with estimated ages[edit]. Note: The ages of the trees in this list are speculative and probably unreliable. ... Individual trees with verified ages[edit]. Name. Age. (years). Species. Location. Country. Notes ... There are three tables of trees, which are listed by age and species. The first table includes trees for which a minimum age ... Age. (years). Species. Location. Country. Notes ?[nb 2]. 5,069. Great Basin bristlecone pine. Pinus longaeva. White Mountains ( ...
Imbrie, John (1979). Ice ages: solving the mystery. Cambridge MA: Harvard University Press. ISBN 978-0-674-44075-3. .. ... There has been a cycle of ice ages for the past 2.2-2.1 million years (starting before the Quaternary in the late Neogene ... Ice core data for the past 800,000 years (x-axis values represent "age before 1950", so today's date is on the left side of the ... It has been observed that ice ages deepen by progressive steps, but the recovery to interglacial conditions occurs in one big ...
Golden age. See also: History of general relativity. In 1958, David Finkelstein identified the Schwarzschild surface as an ... These results came at the beginning of the golden age of general relativity, which was marked by general relativity and black ...
Between ages 10 and 20 the comparable figures are 10.2 and 12.1; and from ages 20 to 44, 25.9 as against 34.3. The percentage ... Clarkson, Tim (2014). Strathclyde and the Anglo-Saxons in the Viking Age. Edinburgh: John Donald. ISBN 978 1 906566 78 4. .. ... The antiquary W G Collingwood, commenting in 1925 about finds in the area, wrote that they showed "Stone Age man was fairly at ... Keswick's recorded history starts in the Middle Ages. The area was conquered by the Anglo-Saxon Kingdom of Northumbria in the ...
The age when CP is diagnosed is important, but medical professionals disagree over the best age to make the diagnosis.[66] The ... Aging[edit]. Children with CP may not successfully transition into using adult services because they are not referred to one ... Zaffuto-Sforza, Celeste D. (February 2005). "Aging with cerebral palsy". Physical Medicine and Rehabilitation Clinics of North ... Prevalence of cerebral palsy is best calculated around the school entry age of about 6 years, the prevalence in the U.S. is ...
Flags of Portugal during the Middle Ages[edit]. Five different flags were used during the period from 1139 until 1415. As seen ... In 1171 Afonso concluded a seven years truce with the Moors; weakened by his wound and by old age, he could no longer take the ... In 1122 Afonso became fourteen, the adult age in the 12th century. He made himself a knight on his own account in Zamora ... In 1184, in spite of his great age, King Afonso of Portugal still had sufficient energy to relieve his son Sancho, who was ...
In the classical age Caieta, famous for its lovely and temperate climate, like the neighbouring Formia and Sperlonga, was a ... Middle Ages[edit]. Further information: Duchy of Gaeta and List of Hypati and Dukes of Gaeta ... On the death of Docibilis II (954), who first took the title dux, the duchy passed from its golden age and entered a decline ... At the beginning of the Middle Ages, after the Lombard invasion, Gaeta remained under suzerainty of the Byzantine Empire. In ...
In the Middle Ages, these included the Abbasids of Baghdad, and the Fatimids, Ayyubids and Mamluks of Egypt.[63] ... Middle Ages[edit]. Despite its spiritual importance, in political terms Arabia soon became a peripheral region of the Islamic ... Age of the Caliphs Expansion under Muhammad, 622-632/A.H. 1-11 ... 3.3 Middle Ages. *3.4 Modern history *3.4.1 Late Ottoman rule ... the stone tools from the Middle Paleolithic age along with fossils of other animals discovered at Ti's al Ghadah, in ...
Golden Age of Sail[edit]. Photo of William D. Lawrence being built at Maitland in 1873. The ship was the longest wooden ship ... Julian Gwyn, "Golden Age or Bronze Moment? Wealth and Poverty in Nova Scotia: The 1850s and 1860s," Canadian Papers in Rural ... Outmigration increased as the 19th century wore on.[80][81] Thus the era was indeed a golden age but mainly for a small and ... The idea of a past golden age came to prominence in the early 20th century by economic reformers in the Maritime Rights ...
For children ages 1-17 years the PRIs increase with age from 120 to 270 μg/day. These values differ somewhat from the U.S. RDAs ... Age Infants (AI) Infants (UL) Children and adults (RDA) Children and adults (UL) Pregnant women (RDA) Pregnant women (UL) ... Age-related macular degeneration[edit]. A sub study of the Women's Antioxidant and Folic Acid Cardiovascular Study published in ... For women and men over age 18 the PRI is set at 330 μg/day. PRI for pregnancy is 600 μg/day, for lactation 500 μg/day. ...
Swank, J.H. (1892). History of the Manufacture of Iron in All Ages, and Particularly in the United States From Colonial Times ... Age[edit]. On the geological timescale, the Marcellus occurs in the Middle Devonian epoch, of the Devonian period, in the ... Relative age dating of the Marcellus places its formation in the Cazenovia subdivision of the Givetian faunal stage, or 391.9 ... Stratigraphically, the Marcellus is the lowest unit of the Devonian age Hamilton Group, and is divided into several sub-units. ...
Williams, Alan (2003). The Knight and the Blast Furnace: A History of the Metallurgy of Armour in the Middle Ages & the Early ... Initially constructed from leather and brass, and then bronze and iron during the Bronze and Iron Ages, they soon came to be ... In European history, well-known armor types include the mail hauberk of the early medieval age, and the full steel plate ... In antiquity and in the Middle Ages, shields were used by foot soldiers and mounted soldiers. Even after the invention of ...
CDCs BAM! Body and Mind is a website designed for kids 9 through 13 years of age to give them the information they need to ... CDCs BAM! Body and Mind is a website designed for kids 9 through 13 years of age, to give them the information they need to ... The U.S. Department of Agriculture provides information on health and nutrition for children over 5 years of age. ... The U.S. Department of Agriculture provides information on health and nutrition for 2 through 5 years of age. ...
Now heres another good reason to get enough sleep: sleep deprivation also could cause your skin to age faster, according to a ... The amount of sleep one needs depends on a persons age. Most experts recommend that adults get between seven and eight hours ... The study involved 60 pre-menopausal women between the ages of 30 and 49, with half of them falling into the poor quality sleep ... Sleep deprived women show signs of premature skin aging and a decrease in their skins ability to recover after sun exposure," ...
A bone age study can help evaluate how a childs skeleton is maturing, which can help doctors diagnose conditions that delay or ... A childs bone age (also called the skeletal age) is assigned by determining which of the standard X-ray images in the atlas ... A difference between a childs bone age and his or her chronological age might indicate a growth problem. But such differences ... which is based on data from large numbers of other kids of the same gender and age. The bone age is measured in years. ...
Persons age 6 months or older: 1 dose any influenza vaccine appropriate for age and health status annually ... HPV vaccination recommended for all persons through age 26 years: 2- or 3-dose series depending on age at initial vaccination ... Adolescents and young adults age 16-23 years (age 16-18 years preferred) not at increased risk for meningococcal disease: Based ... persons with diabetes mellitus age younger than 60 years, shared clinical decision-making for persons age 60 years or older) ...
I would say yes if you are talking about a temporal frame of reference, i.e. Middle Ages vs. Information Age. ... Similar Discussions: Understanding of gravity in the Middle Ages * Middle of gravity (Replies: 5) ... I have read that in the Middle Ages people believed that angels pushed the Moon in its orbit, the angelic push presumably being ... What else did people in the Middle Ages know about gravity? Did they, for example, know that the same force which was ...
... of the NIA funds Nathan Shock Centers of Excellence in the Basic Biology of Aging across the U.S. There are currently 5 funded ... The Division of Aging Biology (DAB) of the NIA funds Nathan Shock Centers of Excellence in the Basic Biology of Aging across ... Personalized Geroscience: Age x Genotype x Environment. June 1-2, Seattle Washington. In coordination with the 2016 AGE meeting ... Develop a Oklahoma Geroscience Consortium to bring together all faculty in Oklahoma who are interested in aging and age-related ...
"Psychology and Aging. American Psychological Association. Retrieved 9 May 2011.. *^ Kahana, Michael. "Age Dissociates Recency ... Normal aging[edit]. Normal aging is associated with a decline in various memory abilities in many cognitive tasks; the ... Age-related memory loss, sometimes described as "normal aging", is qualitatively different from memory loss associated with ... As they age, their ability to multi-task seems to decline; thus after an interruption it is often more difficult for an aging ...
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In a study conducted to understand the effect of aging on carbohydrates digestion and absorption, both older and younger age ... manometric studies of the colon in the elderly fail to identify any age-related decrease in the motility. In the aged colon, ... but not in the younger age groups (3) . Finally, the brush border peptidases seem also to remain intact with older age, and ... it is worth mentioning that serum insulin levels increase with age, but the sensitivity to insulin diminishes with age (1) . ...
Ageless Aging brain American Academy of Anti-Aging Medicine Biogerontology Biological immortality DNA repair DNA damage theory ... Life extension strategies often study the causes of aging and try to oppose those causes in order to slow aging. Rejuvenation ... de Grey, Aubrey; Rae, Michael (September 2007). Ending Aging: The Rejuvenation Breakthroughs that Could Reverse Human Aging in ... was applied as a robust method of decelerating aging and the development of age-related diseases. The biomedical gerontologist ...
We are encouraged to broaden our perspectives of aging and deepen our value of elders in our community. ... service providers about local resources that support senior living and opportunities for community involvement across the ages ... Welcome to Active Aging Coalition Welcome!. This site provides information for seniors, their families, and other senior ... advocates about local resources that support senior living and opportunities for community involvement across the ages.. As of ...
... from the mitotic age of cells to the organismal-wide aging of tissues and organs. The appearance of cancer is only one clinical ... Aging is defined at many levels, from the mitotic age of cells to the organismal-wide aging of tissues and organs. The ... Aging. During an organisms life span almost every aspect of its phenotype will undergo modification. The complexity of aging ... Age-associated epithelial cancers, such as breast cancer, colon cancer, and prostate cancer, however, contribute significantly ...
aging (comparative more aging, superlative most aging) *Becoming elderly. The aging artist could no longer steadily hold the ... Retrieved from "" ...
This site provides concise, structured information about the aging/longevity field, particularly info about aging companies. ... Oct 2020: Added chart on COVID-19 deaths if the aging field had already succeeded:. ... Criteria to separate it from the rest of biotech & from palliative "age-tech". ...
As people age, normal changes occur in their speech, language, memory, and swallowing. In addition, their chances of having a ... The Aging Population. The population in the United States is aging. Between 2010 and 2030, the number of Americans over the age ... Partnership for Health in Aging. The Partnership for Health in Aging (PHA) was formed by the American Geriatrics Society to "to ... There are many organizations dedicated to research on aging, advocating for the elderly, and promoting healthy aging. SLPs ...
The level of investigative activity into the mechanisms of aging at the cellular and molecular level has increased dramatically ... Effects of age on cell division capacity. In: Danon D, Shock NW, Marois M, eds. Aging: A Challenge to Science and Society. New ... Aging and the immune system. In: Warner HR, Butler RN, Sprott RL, et al, eds. Modern Biological Theories of Aging. New York, NY ... Theories of aging: a perspective. In: Warner HL, Butler RN, Sprott RL, et al, eds. Modern Biological Theories of Aging. New ...
... mechanisms of aging. In the session, Aging Mechanisms, two topics were discussed: first is aging at the organismal level, which ... A mutant model mouse is useful for studies of aging. The klotho phenotype (premature aging) is caused by a disruption of the ... Studies of the mutant mouse, klotho, showing premature aging, raise a possibility that mammals have an "anti-aging hormone." A ... Frontier experimental studies of aging at the molecular level are leading to fascinating hypotheses that aging is the price we ...
As we age, our bodies and minds change. Read more. ... National Institute on Aging) * Well-Aged Mind: Maintaining Your ... Participating in the Arts Creates Paths to Healthy Aging (National Institute on Aging) ... The primary NIH organization for research on Healthy Aging is the National Institute on Aging ... National Institute on Aging) * Memory Loss: 7 Tips to Improve Your Memory (Mayo Foundation for Medical Education and Research) ...
These potential treatments for aging could unlock cures to a range of age-related illnesses, from cancer to heart disease. * ... A scientist who studies aging reveals how restricting calories might offer protection against age-related diseases. *Charlotte ... Aging. 3 red states just expanded Medicaid -heres what the midterm election means for healthcare *Lydia Ramsey and Zachary ... 2 forms of exercise are the best way to stave off the effects of aging. Heres how to incorporate them into your life.. *Erin ...
This article reviews literature and research on spirituality and its possible neurobiological mechanisms in relation to aging, ... Feds Sue Yale Hospital for Age Discrimination of Older Clinicians * FDA OKs Anjeso, First Once-Daily IV COX-2 Preferential ... Spirituality & Aging in Modern Society Increasing longevity in modern society puts the spiritual needs of older adults at the ... Not used in clinical settings; young and middle-aged adults may have a harder time accepting the reality of death. Not ...
Honolulus Age-Friendly City Initiative. Major Goal: Consultants for the Honolulu as an Age-Friendly City Initiative, backed by ... Middle-aged and older adults can be especially regarded as valuable assets because they have many years of life experience and ... Volunteers are also more likely: 1) to have more years of education; 2) to be younger in the 50-75 years of age range; 3) to be ... THE UNIVERSITY OF HAWAII CENTER ON AGING TO CONVENE A TASK. FORCE TO ASSESS CURRENT ELDER AND KUPUNA CARE SERVICES AND THE. ...
Current: About Aging. About Aging. The Division of Aging strives to foster networks that provide information, access and long- ... The Division of Aging is committed to helping Hoosiers find the information and resources they need. Our goal is to put ... The Division of Aging supports the development of alternatives to nursing home care and coordinates services through the ... Services are coordinated and funded through Indianas network of Area Agencies on Aging and include the state-funded CHOICE ...
... the number of Americans age 65 and over is projected to reach some 71.5 million people, and nearly 10 million of them will be ... age 85 and older. Today, many seniors report better health, greater wealth, and higher levels of education than seniors in past ... The Fundamentals of Aging. By 2030, the number of Americans age 65 and over is projected to reach some 71.5 million people, and ... Middle-Age Erection Changes: What Couples Need to Know By Michael Castleman M.A. on January 15, 2019 in All About Sex ...
... when the baby boom generation was between the ages of 22 and 40, and when life expectancy at age 62 (the age of eligibility for ... Bulletin on Aging and Health. Book series. The Economics of Aging. International Social Security Jon Skinner, Program Director ... NBER Aging Program. The Economics Of Aging Program involves research on the health and economic circumstances of individuals as ... Work and Retirement at Older Ages. While the determinants of work and retirement have been core components of the Aging Program ...
... to see if flies preferentially select mates on the basis of rate of aging and not not absolute age of its potential mates age ... This is not the first theory of Aging to recognize that the cessation of growth was involved in senescence. G. P. Bidder (1932 ... Proposed experiment to test hypothesis that Mate-Selection drives the persistence of the aging phenotype in Drosophila ... one of the first to speak on the evolution of aging, proposed that aging and subsequent dying occurs to the benefit of the ...
... corrosion and other signs of age at U.S. nuclear power plants have been the root of a growing list of near-miss accidents that ... Nuke Plants Aging Disgracefully. Cracks, corrosion and other signs of age at U.S. nuclear power plants have been the root of a ... Once these things show this type of aging, its time for the utilities to retire them. If a reactor leaks, its time to shut it ... Davis-Besse is among a growing number of aging plants plagued by corrosion and other defects caused by decades of intense heat ...
We are trying to get new furniture for the library. Our working assumption is that some of our furniture is older than your parents. Now, were testing that hypothesis ...
... precipitate throughout the sample by aging at an elevated temperature that is well below the temperature used for the initial ... Other articles where Aging is discussed: metallurgy: Increasing strength: … ... precipitate throughout the sample by aging at an elevated temperature that is well below the temperature used for the initial ...
  • It is expected that there will be 71 million people aged 65 years old and older when all baby boomers are at least 65 years old in 2030. (
  • Baby boomers are now between the ages of 50 and 68, and their initiation of retirement benefits is accelerating. (
  • The societal impact of aging baby boomers is compounded by increasing longevity. (
  • There are approximately 76 million baby boomers in the United States, and their ages range from the early fifties to the early seventies. (
  • The practice of Aging Life Care™ and the role of care providers have captured a national spotlight, as generations of Baby Boomers age in the United States and abroad. (
  • - By 2030, when most American baby boomers will have retired, all the large industrial economies will see a massive increase in the old age population. (
  • Aging Life Care Professionals throughout the country will celebrate National Aging Life Care Month this May by providing seminars, webinars, special events, open houses, and other educational activities for the public. (
  • For example, the official retirement age-now 65-will rise gradually to 66 by 2019. (
  • The Division of Aging held its first webinar as part of its home- and community-based services rate methodology project on Friday, March 22, 2019. (
  • Two decades have past since Caleb Finch in Longevity Senescence and the Genome exhaustively exposed the persistence of negligible senescence in nature and yet the dominant theories of aging continue to lack viable mechanisms or explanations for negligible senescence within their models. (
  • Meet species that exemplify all the realms of aging: longevity, reproductive health, social status, wisdom, and finally, everything that surrounds the final chapter of life, death. (
  • One of the genetic factors that influences the rate of aging and longevity of an organism is the length of telomeres that. (
  • Optimal aging goes beyond good health and longevity. (
  • Because the company aims to market drugs that slow or prevent the diseases of aging rather than extend longevity, sirtuin activators' effects on lifespan may not matter. (
  • Researchers found that those who didn't sleep well exhibited more signs of skin aging including fine lines, uneven pigmentation and reduced skin elasticity. (
  • Recent efforts made by researchers from diverse fields have merged into a line of frontier sciences to search for the "absolute" mechanisms of aging. (
  • This has had a magnetic effect on the size, scope, and productivity of the program as new researchers have been drawn into the field by the prominent senior scholars already working on aging issues. (
  • The Sloan Center on Aging & Work at Boston College understands this need, and has invited international research fellows to connect with researchers in the United States to examine topics on aging in the workplace. (
  • For example, the Sloan Center and other partners have started collaborating with researchers from the Behavioural Science Institute of Radboud University Nijmegen, who have organized a Dutch knowledge platform on sustainable systems of support for aging workers ( ). (
  • Aging in the Wild takes us from the African savannah to the French Alps - and beyond - guided by passionate researchers who reveal their latest discoveries. (
  • Researchers found that seniors who have positive outlooks on aging are 40% more likely to recover from a disability than those with negative attitudes. (
  • Now, researchers at the Salk Institute for Biological Studies have replicated premature aging in the lab, allowing them to study aging-related disease in a dish. (
  • Not so long ago, researchers thought we aged the same way our cars do-after years of wear and tear, the engine is bound to break down. (
  • On Wednesday, some of the leading researchers in the field met at Harvard University to discuss the state of anti-aging science at the Aging & Healthy Lifespan conference. (
  • Researchers have found that by changing just one of the genes that affects aging, they were able to double the worm's lifespan. (
  • Researchers need to study the twin impacts of long-term HIV infection and aging to assess their impact on overall health and well-being. (
  • By pooling several quantitative biomarkers of aging researchers were able to predict the physical and mental performance of test subjects on tasks designed to assess their actual biological age. (
  • In a landmark study sure to provoke interest, researchers from the University of Edinburgh have regenerated an aged organ - in vivo, inside a living animal - to its youthful state though noninvasive manipulation of genes. (
  • and her talk will highlight the primary challenges that researchers face in understanding the key issues facing adults aging with I/DD. (
  • In the recent study, the researchers tested 10 flavonoids , which are naturally occurring compounds with antioxidant and anti-inflammatory properties, in aging mice. (
  • In the 1950s, researchers began to question the validity of accelerated aging tests which relied on dry heat and a single temperature, pointing out that relative humidity affects the chemical processes which produce paper degradation and that the reactions which cause degradation have different activation energies. (
  • This led researchers like Baer and Lindström to advocate accelerated aging techniques using the Arrhenius equation and a realistic relative humidity. (
  • But in a few states, the senior citizen population grew significantly faster than the rest of the country, according to a recent Administration on Aging report. (
  • The Administration on Aging (AoA) is the U.S. federal agency charged with administering the Older Americans Act (OAA), the principal federal legislation promoting client advocacy, system building, and the delivery of social services for America's elderly population. (
  • and insurance/benefits outreach and counseling program (Administration on Aging, ). (
  • To strengthen the involvement of the Administration on Aging in the development of policy alternatives in long-term care by participating in all departmental and interdepartmental activities concerning development of long-term-care health services, review all departmental regulations regarding community-based long-term care, and provide a leadership role for AoA, state, and area agencies in development and implementation of community-based long-term care. (
  • Eldercare Locator is a service by the U.S. Administration on Aging to help users find resources for older adults. (
  • Funded by the Administration on Aging, Dr. Eric Coleman's Care Transition Intervention (CTI) model was selected to be implemented in partnership with the Hospital of Central Connecticut (HCC). (
  • Forward 179 THE AGING OF AMERICA DAVID SATCHER, MD, PhD Centers for Disease Control and Prevention Dramatic shifts are occurring in the structure of the American population. (
  • During the 20th century we have Journal of Health Care for the Poor and Underserved · Vol. 7, No. 3 · 1996 180 The Aging of America witnessed a dramatic change in life expectancy. (
  • Aging is an accumulation of damage to macromolecules, cells, tissues and organs. (
  • Aging is defined at many levels, from the mitotic age of cells to the organismal-wide aging of tissues and organs. (
  • Wear and tear theory: According to the wear and tear theory of aging, tissues and organs eventually die after years of damage. (
  • The Partnership for Health in Aging (PHA) was formed by the American Geriatrics Society to "to prepare America's formal and informal caregiving workforce to provide quality care for America's aging population, and to ensure the financial feasibility of providing that care. (
  • I'm studying whether we can separate the process of functional reprogramming of cells from the process of aging reprogramming of cells. (
  • Age, on the other hand, is just the degree of usefulness of that cell, and it's mostly an epigenetic process. (
  • Rejuvenation is a medical discipline focused on the practical reversal of the aging process. (
  • The appearance of cancer is only one clinical manifestation of the aging process. (
  • While these efforts certainly have yielded a wealth of descriptive information and some fundamental changes in our perception of the aging process, definitive knowledge of the cause or causes of aging remains elusive. (
  • For example, it is not known if all cell populations in the body are vulnerable to aging, or if the nature of the aging process is similar in all cell populations in the body. (
  • Werner's syndrome: a review of its symptomology, natural history, pathology features, genetics and relationship to the natural aging process. (
  • Thus, the aging process is stochastic, and it contrasts with the programmed processes undertaken during early development. (
  • This is an encouraging result because those two constructs are among the first that start to go with the aging process. (
  • The answer is as complex as the aging process itself. (
  • Aging is the process of growing old or maturing. (
  • Although many scientists agree that cross-linking plays a role in aging, there is not enough scientific evidence to confirm that this process is a primary cause of aging. (
  • Although free radicals are needed for the body to produce energy, maintain immunity, transmit nerve signals, produce hormones, and contract muscles, they may also contribute to the process of aging. (
  • The bottom line is we cannot change the fact that we are aging, but we can change how we view the process. (
  • Newswise - LA JOLLA, CA-The current pace of population aging is without parallel in human history but surprisingly little is known about the human aging process, because lifespans of eight decades or more make it difficult to study. (
  • The slow progression and complexity of the aging process makes it very hard to study the pathogenesis of cardiovascular and other aging-related disorders," says Izpisúa Belmonte. (
  • Progeria's striking features resemble the aging process put on fast-forward and afflicted people rarely live beyond 13 years. (
  • Scientists are particularly interested in Progeria in the hopes that it might reveal clues to the normal human aging process. (
  • There is also evidence that defective lamin A accumulates during the normal aging process via the sporadic use of the alternative splice site, " explains Izpisua Belmonte. (
  • Gruman predicts that we're on the cusp of a dramatic change in our expectations about the aging process. (
  • Over the last 20 years, they have found a handful of genes that control the way we age-and they hope to manipulate them to slow the process down. (
  • Why is it that we are told to reduce our wrinkles, and fight the inevitable aging process. (
  • The aging process is inevitable, and every living organism has to go through it whether one likes it or not. (
  • Aging process is a biological phenomenon, which everyone has to undergo at a certain point of life. (
  • Aging process in humans is a complex and natural process that brings about many physical, as well as psychological changes. (
  • Aging is a natural process that takes place as a consequence of various biological events over the course of one's lifespan. (
  • Aging process in men and women works at different pace. (
  • A famous group of studies conducted in 2002 at the University of California at Berkeley suggested that the combination of supplements acetyl-L-carnitine and alpha-lipoic acid could slow the aging process. (
  • adverse reactions (and distinguishing whether adverse reactions are a side effect of medicines or related to the aging process, HIV or something else. (
  • This website will equip you with practical information and effective strategies to help you slow down and/or reverse the aging process! (
  • New research has identified a natural compound found in many types of fruit, such as apples and strawberries, and vegetables that can slow down the aging process. (
  • One key factor in the aging process is known as " cellular senescence ," or the aging of the cell. (
  • In a previous study published in Nature Medicine , scientists at the University of Minnesota Medical School in Minneapolis and the Mayo Clinic in Rochester, MN, noticed that senolytics - which are molecules that target and destroy senescent cells to slow down or prevent the aging process - can effectively prolong an individual's lifespan and improve their health. (
  • Free radicals are unstable atoms that can cause damage to cells and lead to illnesses and the aging process. (
  • Beef aging (American English) or ageing is a process of preparing beef for consumption by aging it, in order to break down the connective tissue within the meat. (
  • Moreover, only the higher grades of meat can be dry aged, as the process requires meat with a large, evenly distributed fat content. (
  • The process of dry-aging usually also promotes growth of certain fungal (mold) species on the external surface of the meat. (
  • Dry-aged beef is typically not sold by most supermarkets in the U.S. today, because it takes time and there is a significant loss of weight during the aging process. (
  • In this context, a material, usually paper, is subjected to extreme conditions in an effort to speed up the natural aging process. (
  • Approximately 25% of U.S. adults 18 years of age and older reported providing care or assistance to a person with a long-term illness or disability in the past 30 days, according to 2009 data from CDC's state-based Behavioral Risk Factor Surveillance System. (
  • Today, NAPCA continues to be the voice of AAPI older adults and their families as leaders in the areas of healthy aging, mature workers, and the prevention of elder abuse. (
  • With the aging of the AAPI senior population, this implies that many AAPI older adults will either enter or remain in the labor force. (
  • [15] Furthermore, the older adults' performances in free recall involved temporal contiguity to a lesser extent than for younger people, indicating that associations regarding contiguity become weaker with age. (
  • [ 6 ] With the growing population of older adults, the role of an elder in the society should be expanded, to enrich and give meaning to lives of its aging citizens. (
  • The curriculum includes analysis of aging issues and using design thinking to develop proposals to help older adults in the community. (
  • The random dial, telephone survey of 859 participants asked middle-aged and older adults about their volunteer experiences, their plans to increase time spent in volunteering, things that motivated them to volunteer, and things that might discourage them from volunteering. (
  • Middle-aged and older adults can be especially regarded as valuable assets because they have many years of life experience and wisdom to share. (
  • For example, since 1988, Independent Sector in Washington, DC has done five biennial national surveys of giving and volunteering behaviors of adults 18 years of age and older. (
  • The findings from this study become the baseline data for Hawaii for middle aged and older adults. (
  • Services are coordinated and funded through Indiana's network of Area Agencies on Aging and include the state-funded CHOICE program (Community and Home Options to Institutional Care for the Elderly and Disabled) and administration of two Medicaid waiver programs providing home- and community-based services for older adults and individuals of all ages with physical impairments. (
  • Adult foster homes offer a less expensive, more home-like atmosphere for aging adults than larger facilities. (
  • After making it through the maelstrom of middle age, many adults find themselves approaching older age wondering "what will give purpose to my life? (
  • Aging Care Connections' mission is to enrich the quality of life in our community by providing older adults and their families with guidance and support that enhances the ability to age well. (
  • We provide comprehensive, coordinated, culturally appropriate long-term health and social services to some of the Bay Area's most vulnerable frail seniors and other adults with disabilities, to help them age in place and prevent more costly health care interventions such as emergency room visits, hospitalizations and premature nursing home placement. (
  • The name change also comes in response to the growing population of adults aged 65 and over and their demand for age-related services. (
  • Aging Life Care™ / geriatric care management is a holistic, client-centered approach to caring for older adults or others facing ongoing health challenges. (
  • Aging Life Care Professionals™ have extensive training and experience working with older adults, people with disabilities, and families who need assistance with caregiving issues. (
  • Missoula Aging Services promotes the independence, dignity and health of older adults and those who care for them. (
  • Unlike a "control group" of adults who did not get regular exercise , the cyclists did not have loss of muscle mass or strength, did not have age-related increases in body fat or cholesterol levels , and their immune systems were as robust as much younger people. (
  • BGSU's Optimal Aging Institute (OAI) was created in 2016 to help middle-aged and older adults, and those who work with them, explore the eight dimensions of health, wellness and resiliency. (
  • 3 Provide learning opportunities and educational materials focusing on optimal aging for service providers, health systems, entrepreneurs, corporations, caregivers, and older adults. (
  • Bowling Green State University's Optimal Aging Institute, the Area Office on Aging of Northwestern Ohio, Inc. and the Wood County Committee on Aging discuss the impact of the opioid crisis on middle-aged and older adults including grandparents who are raising the children of the opioid epidemic. (
  • Her research interests include mixed methodology as well as the social aspects of health and community living among older adults with a specific emphasis on social isolation, aging with lifelong disability. (
  • This conference is intended for adults with an Asperger or related profile who are age 50+. (
  • Just like younger adults, aging adults should pick up the weights and engage in strength training types of workouts on a regular basis-2-3 times per week. (
  • We all want to be strong, independent and fully functioning adults as we age into our 60s, 70s, 80s and beyond. (
  • An aging physician refusing to comply with a new form or yelling at a clerk once when asked to learn a new electronic medical record are inappropriate though not specific assessments for dementia. (
  • The promising new approach could produce many new drugs that combat aging, including diseases like Dementia, Alzheimer's, Stroke and others. (
  • Accordingly, model animals in which a disruption of a single gene leads to the premature phenotype are useful and indispensable for aging studies. (
  • Upon directed differentiation of Progeria-derived iPS cells into smooth muscle cells the premature aging phenotype, including misshapen nuclei, the loss of gene silencing marks and compromised proliferation, reappeared. (
  • The project examines the feasibility of integrating TCARE within the Aging and Disability Resource Center model in the state of HawaiÊ»i. (
  • The North Central Community Choices regional Aging & Disability Resource Center (ADRC) became the first Connecticut ADRC to pilot a Care Transition model that is directly connected an ADRC. (
  • Even at that age, she makes lots of younger women jealous, and turns men's heads wherever she goes. (
  • According to more detailed Eurostat data, 17.4% of Europeans are aged 65 and over, 16.7% are children aged 14 and younger, and 65.8% are working-age people (aged 15 to 64), but even these numbers are averages, and don't give the full, nuanced picture. (
  • Whether it's a few years or a solid decade out, if you've caught yourself feeling younger than your biological age, you're not alone. (
  • For data on the lives of older Americans and their families, see Older Americans 2008: Key Indicators of Well-Being from the Federal Interagency Forum on Aging-Related Statistics. (
  • By 2030, the number of Americans age 65 and over is projected to reach some 71.5 million people, and nearly 10 million of them will be age 85 and older. (
  • The Economics Of Aging Program involves research on the health and economic circumstances of individuals as they age, and on the implications of population aging on the well-being of older persons. (
  • The underlying focus of the program is the study of the health and financial well-being of people as they age, and the larger implications of a population that is increasingly composed of older people. (
  • In just the next 20 years, the U.S. population aged 65 and older is projected to increase from 43 million to 76 million people. (
  • Health affects one's ability to work at older ages, and is strongly associated with financial well-being. (
  • As the population ages and older workers are making up more and more of the labor force, some employers are taking notice and adjusting their own practices to retain valuable experience and skills. (
  • The employment rate of older workers was calculated by dividing the number of employed people between the ages of 55 and 64 by the total population of the same age. (
  • Reproduction concerns not only the young and restless - Aging in the Wild takes a light-hearted look at the issue of sexuality and camaraderie in older animals. (
  • One is the imminent arrival in the older age brackets of the large number of people born in the immediate aftermath of World War II-the baby-boom generation, as it is less-than-attractively called. (
  • The age-65-and-older population in the U.S. grew by 18 percent between 2000 and 2011 to 41.4 million senior citizens. (
  • This Safety Advisor explores the effects of aging on pilot performance and ways to keep flying safely as we grow older. (
  • Older pilots tend to have accumulated more experience and wisdom during the years, and this helps offset certain age-related issues. (
  • For example, a smoker who has hypertension and a family history of heart disease is in reality more likely to perform at an age many years older than his or her chronological age. (
  • Parsons School of Design and AARP's "Disrupt Aging Design Challenge" asks students to design solutions for older clients. (
  • The Harris County Area Agency on Aging (HCAAA) is part of a nationwide network coordinating supportive services for the elderly as mandated by the Older Americans Act of 1965 and its subsequent amendments. (
  • Reports from the CDC suggest that a significant number of new cases of HIV are occurring in people aged 50 or older. (
  • According to figures supplied by the Public Health Agency of Canada (PHAC), about 18% of new HIV cases are occurring among people aged 50 or older. (
  • The effect of these two trends -- living longer with HIV and new HIV infections occurring at an older age -- will have implications for research. (
  • While all five countries share the prospect of an older population, variations in the size and timing of demographic change, as well as important differences in the structure of public programs for the elderly, suggest that population aging will have widely different implications in each country. (
  • Maybe it's just about all of us middle aged folks getting older ourselves. (
  • Persons aged 65 years and older constitute the fastest growing segment of our population. (
  • Between 1950 and 1980, the size of this age group doubled from 12.3 million to 25.5 million, and the "very old" age group, those 85 years and older, experienced a 281 percent increase to become 2.2 million. (
  • In 1995, it was estimated that 33.6 million Americans were aged 65 years and older, 3.6 million of whom were at least 85 years old, and 54,000 were centenarians. (
  • By 2050, overall there will be an estimated 78.8 million Americans in the 65 years and over age category, representing 21 percent of the population.1 Most older Americans are women. (
  • that will change to one in four as the number of persons aged 65 years and older increases. (
  • Heart disease and cancer account for 60 percent of the deaths in persons aged 65 years and older. (
  • The Division of Aging supports the development of alternatives to nursing home care and coordinates services through the statewide INconnect Alliance network. (
  • Aging (senescence) has long been a difficult issue to be experimentally analyzed because of stochastic processes, which contrast with the programmed events during early development. (
  • what we see are the processes by which animals reach old age. (
  • Some of the scientists involved in this study - including Prof. Paul D. Robbins, from the University of Minnesota - teamed up again in order to try to identify which senolytics would be the most effective in slowing down aging processes. (
  • Accelerated aging is testing that uses aggravated conditions of heat, humidity, oxygen, sunlight, vibration, etc. to speed up the normal aging processes of items. (
  • The complexity of aging has led to a plethora of ideas about the specific molecular and cellular causes and how these alterations lead to age-associated diseases, such as epithelial cancers. (
  • The level of investigative activity into the mechanisms of aging at the cellular and molecular level has increased dramatically during the past two to three decades. (
  • Investigative efforts in the area of cellular aging address a number of questions, the answers to which are only beginning to emerge. (
  • Also, the role of aging at the cellular level in the pathogenesis of age-associated diseases, such as arteriosclerotic vascular disease and many carcinomas, remain, for the most part, speculative. (
  • While definitive answers to the questions posed above are not forthcoming at the present time, there is enough information to permit some speculation about future directions that may be pursued in the area of cellular aging. (
  • In this chapter, the current status of cellular aging will be discussed at a level that will provide geriatricians with a foundation of knowledge to assist them in following future developments in the field of basic gerontology. (
  • Schneider EL, Mitsui Y. The relationship between in vitro cellular aging and in vivo human age. (
  • In spite of the fact that the high degree of variability in lifespan across species strongly supports the concept that aging is under genetic control, all three of these theories essentially define senescence as beyond direct regulation by natural selection. (
  • Targeting the genes that control aging not only increases lifespan but seems to improve overall health-so that the animals remain vital as they live longer. (
  • When treating aging mice with fisetin, the team saw that it reduced the levels of senescent cells in the animals, prolonging their lifespan and contributing to better health. (
  • If safety systems fail, aging reactors could leak radiation, which may contaminate the water supply and cause life-threatening diseases and infections. (
  • So some scientists think a drug that targets one of those genes might amp up the repair work and thus help prevent or treat a host of age-related diseases like diabetes or heart disease. (
  • Earlier this year, a group at Pfizer published a study challenging the research that became the cornerstone of Sirtris, a high-profile company that is developing compounds to treat or prevent the diseases of aging. (
  • Understanding how resveratrol works would move pharmacists forwards into the possibilities of an anti-aging drug, although most people would probably prefer to pop a cork rather than a bottle of pills, there are many diseases such as alzheimer's that could potentially be retarded with more focused treatment. (
  • Our study is the first to conclusively demonstrate that inadequate sleep is correlated with reduced skin health and accelerates skin aging. (
  • What Is an Age-Friendly Health System? (
  • Accelerate your adoption of the 4Ms in a virtual community with other health systems and be recognized as an Age-Friendly Health System. (
  • The Division of Aging Biology (DAB) of the NIA funds Nathan Shock Centers of Excellence in the Basic Biology of Aging across the U.S. There are currently 5 funded Centers, in Maine (The Jackson Laboratory), Michigan (University of Michigan), Texas (University of Texas Health Sciences Center in San Antonio), Washington (University of Washington) and New York (Albert Einstein College of Medicine). (
  • What to Expect in your 50's, 60's, and 70's As we age, our health needs are constantly changing. (
  • How much exercise you need depends on your age and health. (
  • Major Goal: Consultants for the Honolulu as an Age-Friendly City Initiative, backed by the Mayor and World Health Organization. (
  • The landscape of health and health care is changing rapidly as well, with lower disability rates by age, continuing advances in medical technology and disease management, increases in health care costs, and significant reforms in health policy. (
  • Mental health issues such as depression and anxiety are NOT a normal part of aging and are hard to discuss, diagnose and treat. (
  • Choice In Aging is one of the oldest and most innovative providers of coordinated health and social services for frail seniors and others with disabilities in the Bay Area. (
  • As we age, the repair team slacks off and our health deteriorates. (
  • AoA was created by Title II of the OAA, and is currently directed by the assistant secretary for aging within the office of the secretary of the Department of Health and Human Services (DHHS). (
  • The AOA has information for health professionals, caregivers, and for elders and families on a variety of aging-related topics. (
  • It includes information on the field of geriatrics as well as links to a physician finder tool and information on aging-related health topics. (
  • This is a service that helps find programs for people ages 55 and over that may pay for some of their costs of prescription drugs, health care, utilities, food, and other essential items or services. (
  • This CDC website has information on a variety of health and aging-related topics, including emergency preparedness, preventive care, advance care planning, chronic disease management, and more. (
  • This site for consumers from the National Library of Medicine includes information on senior health and links to other MedlinePlus pages on aging-related topics. (
  • This website from the National Institutes of Health presents aging-related health information for consumers on topics such as cancer, memory and mental health, vision and hearing, and many more. (
  • This comprehensive guide provides information on various health and lifestyle subjects associated with aging and old age. (
  • The 'Wear and Tear' theory of aging suggests that our health deteriorates due to usage and other external factors, similar to how the value of machinery depreciates. (
  • 1 Become recognized as an educational institution that focuses on optimal aging (with a special emphasis on health, wellness, and preventative care). (
  • I'm a California girl, born and raised here, with an abiding interest in health issues and particularly, healthy aging. (
  • The vacuum packed beef is stored at a temperature of 32 °F to 45 °F (0 °C to 7.2 °C). Food portal Ham, especially country ham: pork aging, Bacon Meat hanging Leone, Brad (16 March 2016). (
  • Age-related memory loss , sometimes described as "normal aging ", is qualitatively different from memory loss associated with dementias such as Alzheimer's disease , and is believed to have a different brain mechanism. (
  • According to recent research, MCI is seen as the transitional state between cognitive changes of normal aging and Alzheimer's disease. (
  • The ADEAR website helps users find Alzheimer's disease information and resources from the National Institute on Aging. (
  • The website of this NIH agency includes publications for consumers, information on Alzheimer's disease, clinical trials, and organizations related to aging. (
  • Goldstein S. Human genetic disorders that feature premature onset and accelerated progression of biological aging. (
  • Aging is an accumulation of biological changes over a period of time. (
  • This essay deals mainly with physiological but not extensively the structural changes that take place in the gastrointestinal system with aging. (
  • Experience with developing assays of physiological age. (
  • Aging typically causes weakness, increased susceptibility to disease and infection, loss of mobility and agility, and age-related physiological changes, such as wrinkled skin and gray hair. (
  • Therefore we are very keen on using our in vitro iPS cell-based model to identify new aging markers and explore other aspects of human premature and physiological aging. (
  • What else did people in the Middle Ages know about gravity? (
  • I have read that in the Middle Ages people believed that angels pushed the Moon in its orbit, the angelic push presumably being in a tangential direction as per the Aristotelian belief that a force is needed to push an object in its direction of motion. (
  • Mild cognitive impairment (MCI) is a condition in which people face memory problems more often than that of the average person their age. (
  • Noteworthy people who had the surgery included Harold McCormick, chairman of the board of International Harvester Company, and the aging premier of Turkey. (
  • While working later in life may seem prudent financially, most people do not continue to work past the typical retirement age. (
  • Since the publication of the Origin of the Species, many people have attempted to identify the fundamental causes of aging. (
  • The European Union reports increasing rates of participation in the labor force by people between the ages of 55 and 64. (
  • Here at Choice In Aging we are working hard to "promote dignity and independence of people with disabilities and special needs" by removing barriers to independence. (
  • In the United States, about two-thirds of people age 65 and over take medications for various conditions. (
  • But people like Appel seem to have a knack for graceful aging. (
  • At age 80 people generally have about 50% to 60% of the muscle mass they had when they were 30. (
  • We find that people who age successfully and have a good quality of life adapt well to changes,' Mosqueda says. (
  • The largest of the grant programs is Title III, State and Community Programs, through which AoA works closely with a network of 9 federal regional offices, 57 state units on aging, 661 substate area agencies on aging, 228 Native American, Alaskan, and Hawaiian tribal organizations, and some 27,000 providers of services to elderly people. (
  • Ages are colour coded: yellow stands for the elderly, pink for children, and blue for working-age people. (
  • For example, Eastern Europe, particularly Poland and Slovakia, have large working-age populations (marked in turquoise and blue), in sharp contrast to the neighbouring Germany which has a high concentration of elderly people in its eastern part near the border with Poland. (
  • The Derek Zoolander Center for People Who Don't Age Good (DZCFPWDAG), a state-of-the-art, anti-aging center in New York City opens today at 4 pm. (
  • But how can design build stronger bonds between people of all ages? (
  • Furthermore, the CDC has forecasted that by the year 2020, more than 50% of HIV-positive people in the U.S. will be over the age of 50. (
  • It is not just the aging of people with longstanding HIV that is occurring. (
  • It is possible that as HIV-positive people age similar dose adjustments may be required. (
  • The burden of coping with multiple conditions may be difficult for some people as they strive to remain high functioning and yet are constrained by the effects of aging. (
  • Between 2010 and 2030, the number of Americans over the age of 65 will double compared to the year 2000. (
  • Racial and ethnic minorities currently comprise 14 percent of Americans aged 65 and overÂ-a number that is expected to increase to 25 percent by the year 2030. (
  • His own research program is nothing if not ambitious: He wants to reverse aging in humans. (
  • In this session, a novel mouse mutant, designated klotho (the name of the Greek goddess who spins the thread of life), was presented to exhibit premature aging similar to that in humans (Fig. 1 ). (
  • Changes You Can Expect as Your Dog Ages BowWOW Here's how your mature dog's age translates into human years: Appropriate Age in Years Equivalent Age in Humans 5 40 6 45 7 50 8 55 9 61 10 66 11 72 12 77 13 82 14 88 15 93 16 99 Change is a normal. (
  • According to the National Alliance for Caregiving (NAC), there are 44 million family caregivers, which is nearly 20 percent of the adult population in the U.S. These caregivers, who are often over the age of 50, provide physical and financial assistance to their elderly loved ones-the NAC also found that while women provide the lion's share of basic care, men also provide financial assistance. (
  • Councils on Aging (COAs) are the community focal point for social and support services to elders, families and caregivers in 349 cities and towns in Massachusetts. (
  • Caregivers helping an aging parent may be recruited to care for a pet right along with caring for its owner. (
  • Underlying all of these theories is the assumption that aging occurs from the bottom-up, beginning with damage to DNA and proteins and ending with organismal frailty, disability, and disease. (
  • Campisi J (2005) Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors. (
  • In the session, Aging Mechanisms , two topics were discussed: first is aging at the organismal level, which is genetically determined, and the second focused on the mechanisms by which cells know when to stop their proliferation. (
  • Age-associated epithelial cancers, such as breast cancer , colon cancer, and prostate cancer , however, contribute significantly to the morbidity and mortality of the elderly and are the second leading cause of death. (
  • There are many organizations dedicated to research on aging, advocating for the elderly, and promoting healthy aging. (
  • As such, it is charged with providing leadership within the aging network of state and area agencies and of service providers for the elderly, and with coordinating activities of other federal agencies involved with aging. (
  • With the Area Agency on Aging acting as an advocate, awareness of the needs of the elderly increases through services that assist the elderly and their families with options that promote independence, well-being and dignity. (
  • The dysfunction address of age to buy viagra research is doctor well better and to a direct left- online as looked at than major uses. (
  • Most middle-age men don't have erectile dysfunction, but their erections change, often causing consternation. (
  • In addition, it has been suggested, but not proven, that cross-linking of proteins in the walls of arteries or the kidneys may be partly responsible for hardening of the arteries (atherosclerosis) and age-related kidney dysfunction. (
  • As we age, our skin elasticity starts to deplete, thus leading to sagging skin. (
  • It's not surprising that this demographic is often bombarded by the media with anti-aging everything: skin creams for every part of our bodies, miracle "cures" for our wrinkles, youthful colors for our hair. (
  • Creams are usually a good choice for aging skin. (
  • Everywhere you turn in the beauty isles of Walmart are signs and advertisements for "anti-aging" creams, and wrinkle reducing makeup. (
  • But such differences don't always mean there's a problem, because perfectly healthy kids can have bone ages that differ from their chronological ages. (
  • What Do We Know about Healthy Aging? (
  • The secret to healthy aging? (
  • Are the keys to healthy aging hiding in the DNA of animals? (
  • Living a healthy lifestyle as we age not only benefits our bodies, but also our minds. (
  • Alkaline water: An easy, healthy and proven way to reverse aging. (
  • The population in the United States is aging. (
  • Speech-language pathologists play an important role in working with this aging population. (
  • SLPs should take the initiative to learn more about the aging population and prepare for the increased services this group will demand in the future. (
  • Given the advancing median age of the European population, this trend is welcome. (
  • As Figure 1 shows, 47.4 percent of the European Union population between the ages of 55 and 64 are working, but this means that 52.6 percent are not-a serious loss of human capital. (
  • In fact, vascular smooth muscle cell senescence also plays a role in advanced arteriosclerosis within the normal aging population. (
  • This is the age structure of European population. (
  • Europe is ageing: according to UN estimates, half the region's population are aged 43 and over. (
  • This is consistent with the UN data on total fertility rates (TFR, average number of births per woman of fertile age) in this part of Europe, at around 1.3 in Spain, Portugal and Italy, far below the fertility rate of 2.1 required for simple continuation of the population. (
  • The incidence of cataracts is rising dramatically in Europe as the continent s population ages. (
  • The authors report on national demographic trends, examine the current living conditions of the aged population, explain the structure of the retirement system, and offer estimates of future budgetary costs of the public programs. (
  • An aging society is characterized by a growing proportion of the retired to the active working population. (
  • This research shows for the first time, that poor sleep quality can accelerate signs of skin aging and weaken the skin's ability to repair itself at night," said Dr. Daniel Yarosh, a senior vice president at The Estée Lauder Companies, in a press release. (
  • The Centers provide leadership in the pursuit of basic research into the biology of aging. (
  • What impact will your work have on aging research? (
  • However, research on spirituality struggles to maintain a nonsectarian approach to studying spirituality, owing to the highly heated religious preferences of various authors, [ 17 ] which polarize gerontological literature on spirituality, religiosity and aging. (
  • Today, the substantive importance of research on aging has never been greater. (
  • Over the last 28 years, the NBER's Program on the Economics of Aging has helped to transform this field from an exploratory new research area into a well-recognized and influential subfield of the economics profession. (
  • NIA's recognition of the analytic value of economic research in aging and its support for a highly integrated program of investigators working collaboratively on aging issues was path-breaking. (
  • This support has been critical to development of the NBER program, the research subfield, and our understanding more generally of people's well-being as they age. (
  • The NBER's Aging Program continues to be anchored by NIA Center and Program Project grants, and by multiple NIA-funded research projects that are administered under the coordinating umbrella of the program. (
  • The program has thrived through its history by simultaneously recruiting and inspiring some of the most prominent, established economics scholars along with more emerging scholars to develop a research agenda on economic issues related to aging. (
  • The program has also been leveraged by substantial research development support provided by NIA, including an NIA-funded training program on the economics of aging and NIA funding for pilot projects. (
  • The training program alone has supported about 150 investigators, the large majority of whom have developed a long-term research agenda on the economics of aging. (
  • In research to be published in The Netherlands later this year ( De Lange, Schalk, Van der Heijden, 2013 ), we discuss negative "push" factors that make it hard for aging workers to stay in their jobs. (
  • A piece in Nature outlines the rather technical arguments over Sirtris's sirtuin activators and what it might mean for the company and for anti-aging research more broadly. (
  • New research is showing the properties of a chemical present in red wine, known as resveratrol, does indeed have anti-aging properties. (
  • In addition, the secondary esophageal peristalsis, which constitute a major clearence mechanism for refluxed gastric acid, seems to be evoked less frequently and less consistently, this increases the liklyhood of the occurrence of gastroesophageal reflux with age. (
  • As individuals age, the damage caused by free radicals increases. (
  • The Division of Aging strives to foster networks that provide information, access and long-term care options that enhance choice, autonomy and quality of life for Hoosiers. (
  • The Division of Aging is committed to helping Hoosiers find the information and resources they need. (
  • These connections between sleep and skin aging, now supported with solid scientific data, will have a profound effect on how we study skin and its functions. (
  • In aging, degradation of white matter structure has emerged as an important general factor, further focusing attention on the critical white matter connections. (
  • Layer over Powerful-Strength Line-Reducing Concentrate for optimal anti-aging and healthier skin benefits. (
  • Suicide is the third leading cause of death among youth 15 through 24 years of age. (
  • The bone age is measured in years. (
  • During the age work, she tells some years that bob and legally lee sold their consultation to paul, prompting the levitra to attack them. (
  • The NBER's Program on the Economics of Aging began in 1986, when the baby boom generation was between the ages of 22 and 40, and when life expectancy at age 62 (the age of eligibility for Social Security) was nearly three years shorter than it is today. (
  • However, in recent years, many experimental results that contradict this concept by demonstrating increased life-span with increased reproductive capacity leaves this question in aging theory unresolved. (
  • For some years I have been giving thought to the matter of age and aging . (
  • Sue and Gigi started an anti-aging beauty blog about 3 years ago then dropped it.Many friends and followers talked us into starting up again, hence, (
  • The "gang-bangers" ranged in age from 14 to 20, and the "hardcores," who were between 18 to 20 and up, with few over 24 or 25 years old. (
  • According to Dr Sergei Scherbov, a specialist in demographic analysis: "Two hundred years ago, a 60-year-old would be a very old person, [but] someone who is 60 years old today, I would argue, is middle-aged. (
  • Rafael de Cabo at the National Institute on Aging in Baltimore, Maryland, and a co-author on the 2006 Nature paper, says that he has safely tested one of the compounds, SRT1720, in more than 1,000 mice, some of which received the compound for two years. (
  • In 1929, a frequently used method in which 72 hours at 100 degrees Celsius is considered equivalent to 18-25 years of natural aging was established by R. H. Rasch. (
  • A clinical trial commissioned by Estée Lauder and conducted by physician-scientists at University Hospitals (UH) Case Medical Center found that poor sleepers demonstrated increased signs of skin aging . (
  • A bone age X-ray will be done by an X-ray technician in a radiology department within a hospital, a freestanding radiology center, or doctor's office. (
  • On November 1, 1979, a small federal grant gave birth to the National Asian Pacific Center on Aging. (
  • The Mt. Diablo Center and The Bedford Center are programs of Choice in Aging. (
  • The UH Center on Aging and Hawaii Pacific Gerontological Society is proud to announce a scholarship for students with a serious interest in a career in aging, long-term care, and/or death and dying. (
  • Center on Aging, University of Hawaii at Manoa. (
  • The study examines the pension-related aging problem primarily from a fiscal perspective. (
  • AoA's second mission is broader, involving promoting awareness of the needs of the aging beyond grant administration, oversight, and evaluation. (
  • NAPGCM is becoming the Aging Life Care Association (ALCA) to better reflect the broad spectrum of services and expertise offered by its members. (
  • This website has a section for consumers, which includes a directory of homes and services, and other information on aging services. (
  • an alternative notion is that the manifestations of aging are the summation of subtle decrements of function in most or all of the cell populations in the body. (
  • This paper discusses a study analyzing aging populations and public pension schemes. (
  • However, we have recently started to learn the molecular mechanisms that control aging. (
  • Clearly, important additional mechanisms are involved in the regulation of aging. (
  • A family lineage exhibiting progeria (premature aging) indicates that senescence is, at least to some extent, controlled genetically. (
  • The klotho gene encodes a novel protein that appears to function outside of the cells (secreted protein), and thus it is very different from that involved in previously described premature-aging syndromes and cell senescence, which function in the nucleus. (
  • A theory of aging is proposed challenging the concept that economic trade-offs between body repair and reproduction are the primary drivers of senescence. (
  • Relative to aging theory this has remained problematic because It has not been intuitively obvious how senescence can function as a trait that favors the fitness of the individual. (
  • This paper, "Mate-Selection Scale And Aging" (MSSA) describes an additional significant mechanism of aging and provides the rational for the species specific rates of senescence that we see across species from the very short lived to the negligibly senescent. (
  • The visible signs of old age and fragility, what scientists call senescence, do not always present themselves in the same way. (
  • Let's age wisely by not trying to hold on to the past, or by dwelling on the future. (
  • sleep deprivation also could cause your skin to age faster , according to a new study. (
  • The study involved 60 pre-menopausal women between the ages of 30 and 49, with half of them falling into the poor quality sleep category. (
  • A bone age study helps doctors estimate the maturity of a child's skeletal system. (
  • In particular, associative learning, which is another type of episodic memory, is vulnerable to the effects of aging, and this has been demonstrated across various study paradigms. (
  • Life extension strategies often study the causes of aging and try to oppose those causes in order to slow aging. (
  • This study , published in 2012 in The Journal of the American Medical Association, examined the relationship between attitudes about aging and recovery from disabilities. (
  • This reversible suppression of progerin expression by reprogramming and subsequent reactivation during differentiation, provides a unique model system to study human premature aging pathologies," says Izpisúa Belmonte. (
  • In the study, the team assessed 84 male and 41 female cyclists, aged 55 to 79. (
  • A study published in the scientific journal Nature has uncovered at least one source of aging among mammals similar to ourselves, and points in the direction of how to stop it. (
  • New study shows that resveratrol reduces age-induced deterioration of neuromuscular synapses in mice. (
  • i ) Despite the fact that klotho mutant mice show systemic aging phenotypes, only limited organs express the klotho gene endogenously. (
  • It's a serious problem, and it is one of a number of problems that I would call 'aging aircraft' issues that we face with these vehicles,' shuttle program manager Wayne Hale said. (
  • Various issues such as wrinkling, sagging skin, and other problems of aging skin are dealt with on this page. (
  • Now, I'm in the advice and conflict resolution field, focused on issues about aging and aging parents. (
  • Last week, a discovery published by scientists at Northwestern University detailed a new genetic switch that may prove to be a watershed in the fight against aging. (