Aggressive Periodontitis: Inflammation and loss of PERIODONTIUM that is characterized by rapid attachment loss and bone destruction in the presence of little local factors such as DENTAL PLAQUE and DENTAL CALCULUS. This highly destructive form of periodontitis often occurs in young people and was called early-onset periodontitis, but this disease also appears in old people.Periodontitis: Inflammation and loss of connective tissues supporting or surrounding the teeth. This may involve any part of the PERIODONTIUM. Periodontitis is currently classified by disease progression (CHRONIC PERIODONTITIS; AGGRESSIVE PERIODONTITIS) instead of age of onset. (From 1999 International Workshop for a Classification of Periodontal Diseases and Conditions, American Academy of Periodontology)Chronic Periodontitis: Chronic inflammation and loss of PERIODONTIUM that is associated with the amount of DENTAL PLAQUE or DENTAL CALCULUS present. Chronic periodontitis occurs mostly in adults and was called adult periodontitis, but this disease can appear in young people.Periodontal Pocket: An abnormal extension of a gingival sulcus accompanied by the apical migration of the epithelial attachment and bone resorption.Periodontal Diseases: Pathological processes involving the PERIODONTIUM including the gum (GINGIVA), the alveolar bone (ALVEOLAR PROCESS), the DENTAL CEMENTUM, and the PERIODONTAL LIGAMENT.Periodontium: The structures surrounding and supporting the tooth. Periodontium includes the gum (GINGIVA), the alveolar bone (ALVEOLAR PROCESS), the DENTAL CEMENTUM, and the PERIODONTAL LIGAMENT.Periodontal Attachment Loss: Loss or destruction of periodontal tissue caused by periodontitis or other destructive periodontal diseases or by injury during instrumentation. Attachment refers to the periodontal ligament which attaches to the alveolar bone. It has been hypothesized that treatment of the underlying periodontal disease and the seeding of periodontal ligament cells enable the creating of new attachment.Periodontal Index: A numerical rating scale for classifying the periodontal status of a person or population with a single figure which takes into consideration prevalence as well as severity of the condition. It is based upon probe measurement of periodontal pockets and on gingival tissue status.Dental Scaling: Removal of dental plaque and dental calculus from the surface of a tooth, from the surface of a tooth apical to the gingival margin accumulated in periodontal pockets, or from the surface coronal to the gingival margin.Aggregatibacter actinomycetemcomitans: A species of Gram-negative, facultatively anaerobic spherical or rod-shaped bacteria indigenous to dental surfaces. It is associated with PERIODONTITIS; BACTERIAL ENDOCARDITIS; and ACTINOMYCOSIS.Polymorphism, Single Nucleotide: A single nucleotide variation in a genetic sequence that occurs at appreciable frequency in the population.Haplotypes: The genetic constitution of individuals with respect to one member of a pair of allelic genes, or sets of genes that are closely linked and tend to be inherited together such as those of the MAJOR HISTOCOMPATIBILITY COMPLEX.Gingivitis: Inflammation of gum tissue (GINGIVA) without loss of connective tissue.Genotype: The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS.Gingiva: Oral tissue surrounding and attached to TEETH.Dental Plaque: A film that attaches to teeth, often causing DENTAL CARIES and GINGIVITIS. It is composed of MUCINS, secreted from salivary glands, and microorganisms.Eikenella corrodens: Gram-negative bacteria isolated from infections of the respiratory and intestinal tracts and from the buccal cavity, intestinal tract, and urogenital tract. They are probably part of the normal flora of man and animals.Gingival Crevicular Fluid: A fluid occurring in minute amounts in the gingival crevice, believed by some authorities to be an inflammatory exudate and by others to cleanse material from the crevice, containing sticky plasma proteins which improve adhesions of the epithelial attachment, have antimicrobial properties, and exert antibody activity. (From Jablonski, Illustrated Dictionary of Dentistry, 1982)Porphyromonas gingivalis: A species of gram-negative, anaerobic, rod-shaped bacteria originally classified within the BACTEROIDES genus. This bacterium produces a cell-bound, oxygen-sensitive collagenase and is isolated from the human mouth.Tooth Loss: The failure to retain teeth as a result of disease or injury.Dental Plaque Index: An index which scores the degree of dental plaque accumulation.

Humoral immune responses in periodontal disease may have mucosal and systemic immune features. (1/126)

The humoral immune response, especially IgG and IgA, is considered to be protective in the pathogenesis of periodontal disease, but the precise mechanisms are still unknown. Immunoglobulins arriving at the periodontal lesion are from both systemic and local tissue sources. In order to understand better the local immunoglobulin production, we examined biopsy tissue from periodontitis lesions for the expression of IgM, IgG, IgA, IgE and in addition the IgG and IgA subclasses and J-chain by in situ hybridization. Tissues examined were superficial inflamed gingiva and the deeper granulation tissue from periodontal sites. These data confirm that IgM, and IgG and IgA subclass proteins and J-chain can be locally produced in the periodontitis tissues. IgG1 mRNA-expressing cells were predominant in the granulation tissues and in the gingiva, constituting approx. 65% of the total IgG-expressing plasma cells. There was a significantly increased proportion of IgA-expressing plasma cells in the gingiva compared with the granulation tissue (P < 0.01). Most of the IgA-expressing plasma cells were IgA1, but a greater proportion expressed IgA2 mRNA and J-chain mRNA in the gingival tissues (30.5% and 7.5%, respectively) than in the periodontal granulation tissues (19% and 0-4%, respectively). The J-chain or dimeric IgA2-expressing plasma cells were located adjacent to the epithelial cells, suggesting that this tissue demonstrates features consistent with a mucosal immune response. Furthermore, we were able to detect the secretory component in gingival and junctional epithelial cells, demonstrating that the periodontal epithelium shares features with mucosal epithelium. In contrast, deeper tissues had more plasma cells that expressed IgM, and less expressing IgA, a response which appears more akin to the systemic immune response. In conclusion, this study suggests that immune mechanisms involved in the pathogenesis of periodontitis may involve features of both the mucosal and systemic immune systems, dependent on tissue location.  (+info)

Neutrophil dysfunctions, IL-8, and soluble L-selectin plasma levels in rapidly progressive versus adult and localized juvenile periodontitis: variations according to disease severity and microbial flora. (2/126)

We used flow cytometry to analyze the expression of adhesion molecules and the oxidative burst of whole-blood polymorphonuclear neutrophils (PMN) from 26 patients with periodontitis. Three different clinical entities were studied: adult periodontitis (AP), localized juvenile periodontitis (LJP), and rapidly progressive periodontitis (RPP). Unstimulated PMN from the patients showed reduced Lewis x, sialyl-Lewis x, and L-selectin expression relative to those from healthy control subjects. These alterations were present whatever the severity of periodontal disease. However, PMN from RPP patients showed increased basal H2O2 production and decreased L-selectin shedding. These latter impairments, which correlated with increased IL-8 plasma levels, could contribute to initial vascular damage. In addition, decreased IL-8 priming of H2O2 production by PMN from RPP patients could account for a lower bactericidal capacity of PMN, leading to the large number of bacteria in the subgingival region of RPP patients. Soluble L-selectin plasma levels were also decreased in the RPP group, indicating more severe or diffuse endothelial damage. These abnormalities were not found in the patients with less destructive forms of periodontitis (AP and LJP). Porphyromonas gingivalis, a bacterial pathogen known to increase IL-8 production by PMN, was found in the periodontal pockets of RPP patients only. These results show links among PMN abnormalities, the clinical form of periodontitis, and the gingival bacterial flora.  (+info)

Localisation of a gene for prepubertal periodontitis to chromosome 11q14 and identification of a cathepsin C gene mutation. (3/126)

Prepubertal periodontitis (PPP) is a rare and rapidly progressive disease of young children that results in destruction of the periodontal support of the primary dentition. The condition may occur as part of a recognised syndrome or may occur as an isolated finding. Both autosomal dominant and recessive forms of Mendelian transmission have been reported for PPP. We report a consanguineous Jordanian family with four members affected by PPP in two nuclear sibships. The parents of the affected subjects are first cousins. We have localised a gene of major effect for PPP in this kindred (Zmax=3.55 for D11S901 at theta=0.00) to a 14 cM genetic interval on chromosome 11q14 flanked by D11S916 and D11S1367. This PPP candidate interval overlaps the region of chromosome 11q14 that contains the cathepsin C gene responsible for Papillon-Lefevre and Haim-Munk syndromes. Sequence analysis of the cathepsin C gene from PPP affected subjects from this Jordanian family indicated that all were homozygous for a missense mutation (1040A-->G) that changes a tyrosine to a cysteine. All four parents were heterozygous carriers of this Tyr347Cys cathepsin C mutation. None of the family members who were heterozygous carriers for this mutation showed any clinical findings of PPP. None of the 50 controls tested were found to have this Tyr347Cys mutation. This is the first reported gene mutation for non-syndromic periodontitis and shows that non-syndromic PPP is an allelic variant of the type IV palmoplantar ectodermal dysplasias.  (+info)

Regulation of immunoglobulin G2 production by prostaglandin E(2) and platelet-activating factor. (4/126)

Patients with localized juvenile periodontitis (LJP) have elevated levels of immunoglobulin G2 (IgG2) in their sera. This is also observed in vitro when peripheral blood leukocytes from LJP patients are stimulated with pokeweed mitogen. In previous studies, we showed that lymphocytes from subjects with no periodontitis (NP subjects) produced substantial amounts of IgG2 when they were cultured with monocytes from LJP patients (LJP monocytes). These observations indicate that monocytes or monocyte-derived mediators are positive regulators of the production of IgG2. The present study was initiated to determine if secreted factors from LJP monocytes were capable of enhancing IgG2 production and to determine if prostaglandin E2 (PGE(2)), which LJP monocytes produce at elevated levels, enhances IgG2 production. Experiments in a transwell system and with monocyte-conditioned media indicated that cell-cell contact was not necessary for LJP monocytes to augment the production of IgG2 by T and B cells from NP subjects. Moreover, the production of IgG2 was selectively induced by the addition of PGE(2) or platelet-activating factor (PAF), another lipid cytokine, which can elevate PGE(2) synthesis. Furthermore, IgG2 production was abrogated when cells were treated with indomethacin, a cyclooxygenase inhibitor that blocks the synthesis of PGE(2), or the PAF antagonists CV3988 and TEPC-15. The effects of indomethacin were completely reversed by PGE(2), indicating that this is the only prostanoid that is essential for the production of IgG2. Similarly, PGE(2) reversed the effects of a PAF antagonist, suggesting that the effects of PAF are mediated through the induction of PGE(2) synthesis. Together, these data indicate that PGE(2) and PAF are essential for the production of IgG2.  (+info)

Th1 and Th2 cytokine profile in patients with early onset periodontitis and their healthy siblings. (5/126)

Early onset periodontitis (EOP) is a chronic inflammatory periodontal disease with a strong genetic link affecting individuals aged 17 to 25. In the familial studies we tested the hypothesis about the role of Th1 and Th2 cytokines in the pathogenesis of EOP disease. The study involved 6 individuals with EOP disease and their 6 siblings with healthy periodontium. Actinobacillus actinomycetemcomitans (A. a), a bacterium typical for EOP, was detected in all people studied. Th1 and Th2 cytokine production was measured after in vitro stimulation. Peripheral blood mononuclear cells (PBMC) were isolated and cultivated for 24 h and 7 days with PWM, A. a. or Escherichia coli. The levels of IL-4, IFN-gamma, IgA, IgG and IgM were measured by ELISA methods. After in vitro stimulation of PBMC, a significantly higher production of IL-4 and significantly lower production of IFN-gamma were found in the group of patients compared with their healthy siblings. The increased level of IL-4 in patients was in good agreement with an increased level of IgM after stimulation of lymphocytes with E. coli. These results support Seymour's hypothesis according to which patients with progressive disease primarily activate Th2 lymphocytes while non-susceptible individuals activate Th1 lymphocytes.  (+info)

Beyond the specific plaque hypothesis: are highly leukotoxic strains of Actinobacillus actinomycetemcomitans a paradigm for periodontal pathogenesis? (6/126)

Actinobacillus actinomycetemcomitans is a facultative anaerobe implicated in a variety of periodontal diseases. Its presence is most closely associated with localized juvenile periodontitis (LIP), although the exact role of the organism in this and other periodontal diseases is not entirely clear. While A. actinomycetemcomitans produces several different putative virulence factors, the most widely studied is the leukotoxin. The leukotoxin selectively kills polymorphonuclear leukocytes and macrophages in vitro, constituting the host's first line of defense. Interestingly, even though all strains of A. actinomycetemcomitans have the genes encoding the leukotoxin, there is variability in leukotoxin expression. Differences in the structure of the promoter region of the leukotoxin gene operon were shown to correlate directly with levels of leukotoxin production. Highly leukotoxic forms appear to exhibit increased pathogenic potential, as evidenced by recent studies that have shown a significant association between the prevalence of such strains and the occurrence of LIP in several different populations. This represents the first demonstration of an association between a particular subset of a pathogenic species and a specific periodontal disease. Early identification of A. actinomycetemcomitans by microbial and genetic assays to evaluate leukotoxicity may enhance the efficacy of preventive and/or therapeutic techniques. Future investigations should continue to evaluate pathogenic variations of additional virulence factors expressed in vivo, not only of A. actinomycetemcomitans, but also of other periodontal bacteria and infectious disease pathogens.  (+info)

Defective Gi protein coupling in two formyl peptide receptor mutants associated with localized juvenile periodontitis. (7/126)

The formyl peptide receptor (FPR) is a prototypical chemoattractant receptor expressed in neutrophils. It is well known that the FPR couples to G(i) proteins to activate phospholipase C, chemotaxis, and cytotoxic cell functions, but the in vivo role of the FPR in man has remained elusive. Recently, F110S and C126W mutations of the FPR have been associated with localized juvenile periodontitis. We studied FPR-F110S and FPR-C126W in comparison with wild-type FPR (FPR-WT) by coexpressing epitope-tagged versions of these receptors with the G protein Galpha(i2)beta(1)gamma(2) in Sf9 insect cells. FPRs were efficiently expressed in Sf9 membranes as assessed by immunoblotting using the beta(2)-adrenoreceptor as a standard. FPR-C126W differed from FPR-WT and FPR-F110S in migration on SDS-polyacrylamide gels and tunicamycin-sensitive glycosylation. FPR-WT efficiently reconstituted high-affinity agonist binding and agonist- and inverse agonist-regulated guanosine 5'-O-(3-thiotriphosphate) (GTPgammaS) binding to Galpha(i2)beta(1)gamma(2). In contrast, FPR-F110S only weakly reconstituted agonist-stimulated GTPgammaS binding, and FPR-C126W was completely inefficient. Collectively, our data show almost complete and complete loss of G(i) protein coupling in FPR-F110S and FPR-C126W, respectively. The severe functional defects in FPR-F110S and FPR-C126W contrast with the discrete clinical symptoms associated with these mutations, indicating that loss of FPR function in host defense is, for the most part, readily compensated.  (+info)

Population structure and genetic diversity of Actinobacillus actinomycetemcomitans strains isolated from localized juvenile periodontitis patients. (8/126)

The phylogeny of 20 Actinobacillus actinomycetemcomitans strains isolated from patients with localized juvenile periodontitis (LJP) was investigated by using partial sequence analysis of 16S rRNA genes, arbitrarily primed PCR (AP-PCR), and four additional PCR assays that amplified polymorphic regions in the leukotoxin (lkt), cytolethal distending toxin (cdt), major fimbrial subunit (flp-1), and serotype-specific O polysaccharide gene clusters. Our analysis also included four strains isolated from healthy subjects and nine reference strains. We found that A. actinomycetemcomitans strains comprised three major phylogenetic lineages. One lineage consisted of serotype b strains, a second lineage consisted of serotype c strains, and a third lineage consisted of serotype a, d, e, and f strains. 16S rRNA sequences within each lineage were highly conserved (<1% base substitutions), whereas sequences between lineages were exceptionally divergent (1.9 to 5.0% substitutions). Two strains exhibited 16S rRNA sequences that were even more distantly related to those of the three major lineages (2.7 to 6.7% substitutions), indicating that additional minor lineages or variants exist. The distribution of 16S rRNA sequences and lkt, cdt, flp-1, and AP-PCR genotypes was consistent with a clonal population structure, with little evidence of assortative recombination between strains of different serotypes. Strains from all three major lineages were recovered from LJP patients, suggesting that phylogenetically diverse strains of A. actinomycetemcomitans carry pathogenic potential.  (+info)

*Epidemiology of periodontal diseases

Aggressive periodontitis was found in 5.9% of the subjects (4.3% localized and 1.6% generalized). This was significantly ... Levin L, Baev V, Lev R, Stabholz A, Ashkenazi M (August 2006). "Aggressive periodontitis among young Israeli army personnel". J ... Albandar, JM; Muranga, MB; Rams, TE (2002). "Prevalence of aggressive periodontitis in school attendees in Uganda". Journal of ... Ereş, G; Saribay, A; Akkaya, M (2009). "Periodontal treatment needs and prevalence of localized aggressive periodontitis in a ...

*Periodontitis

The seven categories are as follows: Gingivitis Chronic periodontitis Aggressive periodontitis Periodontitis as a manifestation ... Periodontitis is caused by microorganisms that adhere to and grow on the tooth's surfaces, along with an over-aggressive immune ... According to some researchers periodontitis may be associated with higher stress. Periodontitis occurs more often in people ... although this may be a symptom of progressing periodontitis in that patient. Periodontitis has been linked to increased ...

*Gingivitis

While some cases of gingivitis never progress to periodontitis, data indicates that periodontitis is always preceded by ... poor oral hygiene overly aggressive oral hygiene such as brushing with stiff bristles mouth-breathing during sleep medications ... Periodontitis can ultimately lead to tooth loss. The term means "inflammation of the gum tissue". The symptoms of gingivitis ... Recurrence of gingivitis Periodontitis Infection or abscess of the gingiva or the jaw bones Trench mouth (bacterial infection ...

*Periodontal pathology

"Adult periodontitis" was reclassified "chronic periodontitis" and "early-onset periodontitis" to "aggressive periodontitis". ... Aggressive periodontitis may occur in younger persons and there may a genetic aspect, with the trait sometimes running in ... Aggressive periodontitis is distinguished from the chronic form mainly by the faster rate of progression. Loss of attachment ... adult periodontitis, early-onset periodontitis, periodontitis associated with systemic disease, necrotizing ulcerative ...

*Aggressive periodontitis

Localized aggressive periodontitis (LAP) Generalized aggressive periodontitis (GAP) Aggressive periodontitis is much less ... Aggressive periodontitis runs in the patient's family. Familial aggregation of aggressive periodontitis is often discovered by ... Aggressive periodontitis describes a type of periodontal disease and includes two of the seven classifications of periodontitis ... aggressive periodontitis was defined according to 3 primary features, in contrast to chronic periodontitis. These features are ...

*Lautropia mirabilis

"Microbiological Characterization in Children with Aggressive Periodontitis". Journal of Dental Research. 91 (10): 927-933. doi: ... There have been, however, a number of recent studies that identified the bacteria in healthy patients without periodontitis and ... "Impact of Periodontal Therapy on the Subgingival Microbiota of Severe Periodontitis: Comparison Between Good Responders and ... have also found that the bacterium is more commonly found in healthier patients when compared to patients with periodontitis. ...

*Periodontal pathogen

Infection patterns in chronic and aggressive periodontitis. J Clin Perio 2005;32:1055-1061. ... Periodontal pathogens are bacteria that have been shown to significantly contribute to periodontitis. Although approximately ... of species that have been shown to be more closely related to the initial incidence and continued persistence of periodontitis ...

*Zygoma Implant

... patients who have heavily broken down teeth or very mobile teeth due to diseases such as generalised aggressive periodontitis. ... "Fixed rehabilitation of patient with aggressive periodontitis using zygoma implants". Indian J Dent Res. 21. Kahnberg, Karl- ...

*Jørgen Slots

... in aggressive periodontitis, previously known as juvenile periodontitis. In 1982, Slots developed tryptic soy-serum-bacitracin- ... It was Slots' work, along with that of Newman, Socransky and others, that substantiated aggressive periodontitis as a bona fide ... Fryman A, Simonian K. Aggressive periodontitis: the historic quest for understanding. CDA Journal 2011;39(6):377-382. ... The predominant cultivable organisms in juveline periodontitis. Scand J Dent Res 1976;84(1):1-10 van Steenbergen, TJM. " ...

*Aggregatibacter actinomycetemcomitans

Its role in aggressive periodontitis was first discovered by Danish-born periodontist Jørgen Slots, a professor of dentistry ... Although it has been found more frequently in localized aggressive periodontitis, prevalence in any population is rather high. ... 1985). The species has attracted attention because of its association with localized aggressive periodontitis. Recent studies ... non-motile bacterium that is often found in association with localized aggressive periodontitis, a severe infection of the ...

*Formyl peptide receptor 1

SNPs in aggressive periodontitis patients". Genes and Immunity. 4 (1): 22-9. doi:10.1038/sj.gene.6363900. PMID 12595898. ...

*Maresin

"Maresin 1 Biosynthesis and Proresolving Anti-infective Functions with Human-Localized Aggressive Periodontitis Leukocytes". ... that macrophages derived by culturing the monocytes isolated from the blood of patients with Localized aggressive periodontitis ...

*KRT23

2004). "Single nucleotide polymorphisms associated with aggressive periodontitis and severe chronic periodontitis in Japanese ...

*Debridement (dental)

In cases of aggressive periodontitis three major species of bacteria have been identified within the periodontal pocket. These ...

*DGKG

... of mRNAs for the various diacylglycerol kinase isoforms in neutrophils from patients with localized aggressive periodontitis". ...

*Capnophile

found in the mouth (e.g. Aggregatibacter actinomycetemcomitans). These are a cause of aggressive juvenile periodontitis. ...

*Oral microbiology

... its association with localized aggressive periodontitis in young adolescents, and studies indicating that it can cause bone ...

*Chronic periodontitis

Major drivers of this aggressive tissue destruction are matrix metalloproteinases (MMPs), cathepsins, and other osteoclast- ... "Patients with periodontitis were more likely to have poorly differentiated oral cavity SCC than those without periodontitis ( ... Chronic periodontitis is a common disease of the oral cavity consisting of chronic inflammation of the periodontal tissues that ... Title = Custom Tray Application of Peroxide Gel as an Adjunct to Scaling and Root Planing in the Treatment of Periodontitis: A ...

*Marsh rice rat

Periodontitis. Animal model: periodontitis in the rice rat (Oryzomys palustris). American Journal of Pathology 96(2):643-646. ... They are aggressive towards conspecifics and emit high-pitched squeaks while fighting. In dense vegetation, their perceptual ... The marsh rice rat is quite susceptible to periodontitis and has been used as a model system for the study of that disease. The ... Rice rats also eat eggs and young of the seaside sparrow (Ammodramus maritimus) and are aggressive towards the sparrow, ...

*Prevotella nigrescens

When P. nigrescens microflora colonize they trigger an over-aggressive response from the immune system and increase the ... "Association of periodontitis with increased colonization byPrevotella nigrescens". Journal of Investigative and Clinical ... and Porphyromonas gingivalis are associated with signs of carotid atherosclerosis in subjects with and without periodontitis". ...

*List of diseases (P)

Periodontitis Perioral dermatitis Peripartum cardiomyopathy Peripheral blood vessel disorder Peripheral nervous disorder ... Parturiphobia Paruresis Parvovirus antenatal infection Pascuel-Castroviejo syndrome Pashayan syndrome Passive-aggressive ...

*Advanced glycation end-product

... periodontitis and neuropathy. The pathogenesis of this process hypothesized to activation of the nuclear factor kappa B (NF-κB ... peptides and free adducts-are more aggressive than the AGE proteins from which they are derived, and they can perpetuate ...

*Mir-185 microRNA precursor family

"Regulation of Cancer Aggressive Features in Melanoma Cells by MicroRNAs". PLoS ONE. 6 (4): e18936. doi:10.1371/journal.pone. ... Perri, R.; Nares, S.; Zhang, S.; Barros, S. P.; Offenbacher, S. (2011). "MicroRNA Modulation in Obesity and Periodontitis". ...

*Valeant Pharmaceuticals

Setting on a path of aggressive acquisitions, Pearson would ultimately turn Valeant into a platform company that grows by ... an antibiotic used for procedures related to periodontitis Jublia, for treatment of toenail fungus Acne drugs: Solodyn, Ziana, ... Valeant said that it would cut ties with Philidor in response to allegations of aggressive billing practices. Walgreens Boots ...

*Low level laser therapy

Similarly, the use of lasers to treat chronic periodontitis and to speed healing of infections around dental implants is ... There is nothing wrong with using such a treatment given appropriate informed consent, but the aggressive marketing of laser ... "The Effect of Laser Therapy as an Adjunct to Non-Surgical Periodontal Treatment in Subjects with Chronic Periodontitis: A ...

*Induced stem cells

... aggressive, teratoma-initiating embryonic-like carcinoma cells during differentiation. The survival of these teratoma- ... regeneration and are a promising source of readily accessible stem cells for use in the clinical treatment of periodontitis. ...
OBJECTIVES: The objectives of this study were to characterize the bacterial profile and to seek possible bacterial associations in the subgingival microbiota of early onset periodontitis/aggressive periodontitis patients by using two different techniques, culture and immunofluorescence. MATERIAL AND METHODS: The study group consisted of 66 systemically healthy individuals with evidence of early onset periodontitis - 41 females and 25 males aged 23-35 years (mean 31.1 +/- 3.1 years). Bacterial samples were collected from the deepest site in each quadrant, resulting in a total of 264 sites with a mean probing pocket depth of 6.6 +/- 1.5 mm. Samples were cultured anaerobically and in 10% CO(2) using selective and nonselective media, and isolates were characterized to species level. Indirect immunofluorescence using monoclonal antibodies was applied to detect Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis, Tannerella forsythia (Bacteroides forsythus, Tannerella forsythensis), ...
Define Juvenile Periodontitis. Juvenile Periodontitis synonyms, Juvenile Periodontitis pronunciation, Juvenile Periodontitis translation, English dictionary definition of Juvenile Periodontitis. n dentistry the inflammation of periodontal tissue n. 1. inflammatory disease of the periodontium. 2. pyorrhea . Noun 1. periodontitis - a disease that...
A multifactorial risk pattern of periodontitis has been recognized, where in addition to host and environmental factors, a pathogenic microbiota plays a primary role. The purpose of the current research was to analyze the prevalence of periodontitis-associated microorganisms in patients with aggressive periodontitis and periodontally healthy elders by using molecular-biologic detection methods like eubacterial PCR-amplification of 16S rDNA in combination with dot-blot hybridization. The oligonucleotide probes for the detection of T. forsythensis, P. gingivalis, A. actinomycetemcomitans, C. rectus, F. nucleatum, Fusobacterium spp., P. intermedia, E. corrodens, V. parvula and C. ochracea were designed and evaluated. The PCR products of 42 cultivated target and closely related bacteria were used for the optimization of hybridization conditions. For the epidemiological study, subgingival plaque was sampled from four pockets and one healthy site of 45 aggressive periodontitis patients as well as from ...
Background: Periodontitis is a multifactorial chronic inflammatory disease characterized by destruction of tooth-supporting tissues. Environmental and genetic factors as well as the immune system participate in this process. Recent studies have attempted to elucidate the role of cytokine networks involved in periodontal diseases. Objective: To assess and compare the levels of IL-4, IL-6 and IL-12 in serum samples of patients with generalized aggressive periodontitis (GAgP) and control individuals. Methods: A total of 50 subjects were included in the study of which 25 patients had generalized aggressive periodontitis and 25 were healthy unrelated age and gender matched patients undergoing extraction and surgical crown lengthening (control group). Local blood samples of patients were collected from surgical sites of pocket reduction and from healthy individuals before tooth extraction or crown lengthening from non inflamed sites. The levels of IL-4, IL-6 and IL-12 were determined by an ELISA assay using
Periodontitis is common, but aggressive periodontitis (AgP) is thought to progress faster than chronic periodontitis (CP). Reviews suggest that tooth loss as a result of periodontitis is in the order of 1.5-9.8%. The aim of this current review was to investigate tooth loss and disease progression in aggressive periodontitis cases. The Medline and Embase databases [read the full story…]. ...
Objectives: Only a few studies have attempted to detect differences in microbiologic profiles of patients with chronic periodontitis (CP) and aggressive periodontitis (AgP). The aim of this analysis was to assess if clinical diagnosis or other subject factors showed association with the presence of Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis in a cohort of periodontitis patients. Method and Materials: Statistical analysis for association between bacterial detection and clinical diagnosis was performed on a total of 267 consecutive periodontitis cases diagnosed with either CP (n = 183) or AgP (n = 84). All subjects had microbiologic samples collected from the four deepest pockets and analyzed by nested polymerase chain reaction. Results: A actinomycetemcomitans was detected in 54% and 48% of CP and AgP subjects, respectively. A slightly higher detection of P gingivalis was found in CP (67%) compared with AgP (52%) cases. The detection of P gingivalis was associated with ...
Background: Interleukin-6 (IL-6) polymorphisms have been shown to affect IL-6 promoter activity. This study investigated the possible role of IL-6 genetic polymorphisms and haplotypes in the predisposition to aggressive periodontitis (AgP). Material and Methods: A case-control association study on 224 AgP patients and 231 healthy controls was performed in order to detect differences in genotype distributions of five single nucleotide polymorphisms (SNPs) located in the promoter region of the IL-6 gene. Results: The IL-6 -1363 polymorphism was associated with a diagnosis of AgP in subjects of all ethnicities (p=0.006, adjusted logistic regression). The -1480 SNP was associated with LAgP in subjects of all ethnicities (p=0.003). The -1480 and -6106 polymorphisms were associated with Localized AgP in Caucasians (n=24) (p=0.007 and 0.010, respectively). Haplotypes determined by the -1363 and -1480 polymorphisms were also associated with LAgP (p=0.001) in Caucasians. Conclusions: This study supports ...
Gum disease is not limited to adults. Periodontitis (inflammation of the supporting tissues of the teeth or also known as the periodontium) can also occur in young people. Periodontal disease can generally be divided into different types including chronic, aggressive and necrotizing periodontal disease; with aggressive periodontitis commonly seen in the younger age group. Continue reading →. ...
Chronic periodontitis and aggressive periodontitis. Their etiopathogenesis, clinical features, risk factors & clinical photographs of patients.
It is also becoming more commonly recognized that chronic periodontitis may occur simultaneously with both localized and generalized forms of aggressive periodontitis
An actinomycetemcomitans can cause localized juvenile periodontitis and certain types of adult periodontitis. Optimal treatment of periodontal disease caused by this microorganism requires systemic antibiotic therapy in addition to mechanical debride
Periodontal diseases are complex inflammatory diseases and affect up to 20% of the worldwide population. An unbalanced reaction of the immune system toward microbial pathogens is considered as the key factor in the development of periodontitis. Defensins have a strong antimicrobial function and are important contributors of the immune system toward maintaining health. Here, we present the first systematic association study of DEFB1. Using a haplotype-tagging single nucleotide polymorphism (SNP) approach, including described promoter SNPs of DEFB1, we investigated the associations of the selected variants in a large population (N=1337 cases and 2887 ethnically matched controls). The 3′ untranslated region SNP, rs1047031, showed the most significant association signal for homozygous carriers of the rare A allele (P=0.002) with an increased genetic risk of 1.3 (95% confidence interval: 1.11-1.57). The association was consistent with the specific periodontitis forms: chronic periodontitis (odds ...
There a multiple appointments throughout the study which can vary depending upon if a patient has the disease present or not.. If the patient has gum disease: At the initial examination, some samples will be collected: the natural fluid that comes from the gums and the bacteria that are present there will be collected by inserting a piece of paper and a filter strip in the spaces between teeth and gums; blood samples may also be taken by a phlebotomist to evaluate some inflammatory signs of disease and possible genetic markers (about 5 teaspoons at each visit); and a cheek swab may be taken by gently rubbing a little brush into the inside of the cheeks. Patients also may be asked to spit into a container we provide. Tissues from gums that are usually discarded may also be collected during treatment. When patients return for re-evaluation of their gums, all these samples may be collected again at 3, 6, 12, 18 and 24 months after the initial therapy. After 24 months, only clinical examinations may ...
... This release is available in German . ...A mutual epidemiological relationship between aggressive periodontitis...The first author Dr Arne Schaefer from the Institute for Clinical Mol...Because it has to be assumed that there is a causal connection between...,Periodontitis,and,myocardial,infarction:,A,shared,genetic,predisposition,biological,biology news articles,biology news today,latest biology news,current biology news,biology newsletters
Occurrence of Actinobacillus actinomycetemcomitans in patients with chronic periodontitis, aggressive periodontitis, healthy subjects and children with gingivitis in two cities of the state of São Paulo, Brazil ...
Periodontitis is an inflammatory disease of the supporting tissues of the teeth, resulting in progressive destruction of the periodontal ligament and alveolar bone with pocket formation, recession, or both. The pathogenic processes are largely a response to microbial induced destructive mechanisms. These processes are initiated by the microbial biofilm, but are undertaken by the host cells in chronic disease progression, and thus it is the host tissue itself that results in the destruction observed. The host initiates and controls the release of enzymes, including matrix metalloproteinases (MMPs), to allow the tissues to retreat from the microbial destructive lesions. Recently, there has been increasing evidence implicating MMPs as key mediators in the tissue destruction associated with the various forms of periodontal disease, including the progression from gingivitis to periodontitis. Aggressive periodontitis (AgP) in children is a severe and rapidly progressing form of periodontitis that may ...
Periodontitis is a common disease that is characterized by resorption of the alveolar bone and mediated by commensal bacteria that trigger host immune responses and bone destruction through unidentified mechanisms. We report that Nod1, an innate intracellular host receptor for bacterial peptidoglycan-related molecules, is critical for commensal-induced periodontitis in a mouse model. Mice lacking Nod1 exhibit reduced bone resorption as well as impaired recruitment of neutrophils to gingival tissues and osteoclasts to the alveolar bone, which mediate tissue and bone destruction. Further analysis showed that accumulation of a Nod1-stimulating commensal bacterium, NI1060, at gingival sites was sufficient to induce neutrophil recruitment and bone resorption. Genomic sequencing revealed that NI1060 is a mouse-specific bacterium that is related to bacteria associated with the development of aggressive periodontitis in humans. These findings provide insight into commensal-host interactions contributing ...
Perio Horizons Dental Health Page discusses important topics for the dental consumer and the health care provider and offer advice on treatment, prevention, and wellness.
We report a case of a girl with a perplexing clinical feature of simultaneous occurrence of periodontal and skin abscesses that resolved following periodontal therapy. Infections and inflammations have the capacity to metastasize and despite the localized nature of periodontal disease, infection of the sulcus/periodontal pocket can lead to inflammatory responses beyond the periodontium. C-Reactive Protein (CRP) is primarily a non-specific marker of inflammation with multiple pro-inflammatory properties and some studies have noted its concurrent reduction and CVD following periodontal therapy. A 12 year old Nigerian girl presented clinically with simultaneous occurrence of aggressive periodontitis, periodontal and skin abscesses with eventual teeth loss. Pre-operative quantitative analysis of plasma CRP was 1500mg/l, moderate growth of Staphylococcus aureus ...
Furthermore, our group re ported that AMZ shortens the duration of treatment method for aggressive periodontitis. Apart from our re ports, many groups showed A
TGF-ß1 is a pleiotropic cytokine that exerts its effects on bone and connective tissue metabolism which are of great importance in periodontal diseases. The expression of TGF-ß1 has been shown to be under genetic control. Two SNPs at codon 10 (L10P) and codon 25 (R25P) represent functionally important genetic variants. Therefore, the aim of this study was to evaluate links between genetic variants of TGF-ß1 and chronic/aggressive periodontitis and its clinical features. Patients and methods: One hundred and forty nine periodontitis patients (chronic: n=68, mean age=48.9+9.6y, 64.2% females; aggressive: n=81, mean age=40+9.5y, 63% females) and 82 healthy controls (mean age=46.6+10.7y, 53.7% females) without periodontitis were included in the study. TGF-ß1 polymorphisms and haplotypes were determined using PCR-SSP (CTS-Kit, Heidelberg, Germany). The clinical investigation included smoking status, plaque (API) and bleeding indexes (BOP), pocket depth (PD) and clinical attachment loss (CAL). ...
No association of genetic variants of interleukin 6 and the susceptibility to periodontitisS Schulz1, J Klapproth1, U Zimmermann1, HG Schaller1, HKG Machulla2, W Altermann2, C Gläser3, S Reichert11 University School of Dental Medicine, Department of Operative Dentistry and Periodonto-logy, 2 Interbranch HLA Laboratory - Department GHATT, and3 Institute of Human Genetics and Medical Biology, Medical School, Martin-Luther-University, Halle, GermanyPeriodontitis as a chronic inflammatory disorder is influenced by environmental and genetic factors. Several factors of the immune response and their genetic background have been proposed as potential markers for the susceptibility to this disease.The aim of the present study was to evaluate the importance of genomic variants of the potent proinflammatory cytokine interleukin 6 (IL6) for the incidence of chronic and aggressive periodontitis. Patients and Methods: In the present study 107 periodontitis patients (chronic: n=48, mean age: 48.1+10.1y, 33.3% ...
There are various systemic antibiotics used to target periodontal diseases including abscesses, aggressive periodontitis and acute necrotising forms.
Contrary to popular belief, periodontal or gum disease is NOT something that only happens to grown-ups and the elderly; children and adolescents are susceptible, too. Broadly speaking, gum diseases refer to a set of ailments resulting from an inflammation of the tissues and bone that support the teeth. If left untreated, it could result in rotting teeth and possible underlying complications. Usually, periodontal disease is caused by a buildup of plaque, a sticky layer of bacteria that naturally forms on teeth and gums. The most common types that affect children are chronic gingivitis and aggressive periodontitis ...
Major advances in the knowledge about the aetiopathogenesis of aggressive periodontitis (AgP) have been achieved. An ever increasing number of scientific articles related to AgP are published every year contributing significantly to the knowledge of this unique and complex disease. AgP has been classified into localised and generalised forms based on their extent and disease progression with distinct clinical and radiological features. A classification of AgP based on severity (mild, moderate and severe) exists; however, it is not easily applicable. Therefore, studies on AgP do not categorise the disease based on severity. A disease staging index for AgP is proposed based on clinical and radiological features, as well as risk factors. Based on the presence or absence of risk factors confirmed by longitudinal studies, cases of AgP can be divided into low risk, medium risk and high risk profiles for disease progression. Clinicians can devise a broad treatment plan for their AgP cases based on this ...
T01960 (aplc,apre,bapi,bgg,bhan,bths,cchv,ceh,chon,cwa,epa,eti,mmas,myi,nab,nhi,pmai,pspo,rdi,tbs,thh,xhr,zdf : calculation not yet completed ...
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Epidemiological studies have indicated a relationship between coronary heart disease (CHD) and periodontitis. Recently, CDKN2BAS was reported as a shared genetic risk factor of CHD and aggressive periodontitis (AgP), but the causative variant has remained unknown. To identify and validate risk variants in different European populations, we first explored 150 kb of the genetic region of CDKN2BAS including the adjacent genes CDKN2A and CDKN2B, covering 51 tagging single nucleotide polymorphisms (tagSNPs) in AgP and chronic periodontitis (CP) in individuals of Dutch origin (n=313). In a second step, we tested the significant SNP associations in an independent AgP and CP population of German origin (n=1264). For the tagSNPs rs1360590, rs3217992, and rs518394, we could validate the associations with AgP before and after adjustment for the covariates smoking, gender and diabetes, with SNP rs3217992 being the most significant (OR 1.48, 95% CI 1.19 to 1.85; p=0.0004). We further showed in vivo gene ...
Objective: The present study was carried out as a multicenter, randomized controlled, split-mouth clinical trial to evaluate the efficacy of locally delivered lycopene on periodontal health and gingival crevicular fluid (GCF) levels of 8-hydroxydeoxyguanosine (8-OHdG) in smokers and nonsmokers compared with periodontally healthy control subjects. Method and Materials: One hundred ten subjects including 50 smokers, 50 nonsmokers, and 10 controls participated in this study. Subjects in the smoker and nonsmoker groups had contralateral sites treated with lycopene gel and a placebo. Clinical parameters included recording site-specific measures of plaque, gingivitis, probing depth, and clinical attachment level. GCF 8-OHdG values were analyzed using a commercially available ELISA kit. Results: Compared with the placebo, lycopene-treated sites in smokers and nonsmokers showed significant reductions in probing depths and gain in the clinical attachment levels. However, there was no statistically ...
Severe forms of chronic periodontitis affect up to 10% of adults. Tumour necrosis factor and lymphotoxin-alpha genes in the major histocompatibility complex are associated with severe periodontitis. Complement factor C4 is a nearby, polymorphic, functionally relevant gene region. Although associated with chronic mucosal infections, C4 deficiencies have not been assessed in adult periodontitis patients. We tested whether complement levels are systemically altered and C4 deficiencies associated with severe chronic periodontitis. In a case-control study, we analysed levels of plasma C3, and C4, serum classical pathway haemolytic activity, C4 allotypes and C4 gene numbers in 37 patients with severe chronic periodontitis and in 150 voluntary controls. Plasma levels of C3 were higher, and classical pathway haemolytic activity was lower in patients than in controls. Partial C4 gene deficiencies were more frequent in patients than in controls (odds ratio 2.4, 95% confidence interval 1.1-5.5, P = 0.032). ...
Periodontitis is a chronic inflammatory disease of tooth supporting tissues resulting in periodontal tissue destruction, which may ultimately lead to tooth loss. The pathogenetic mechanisms of periodontitis are not fully elucidated. The disease is characterized by continuous leukocyte infiltration, likely mediated by local cytokine and chemokine production. There are no serologic biomarkers for the diagnosis of periodontitis, which is based solely on the degree of local tissue destruction. The aim of this study was to identify serological biomarkers for periodontitis by analyzing a spectrum of cytokines in serum from subjects with and without periodontitis and also to investigate if the detected cytokines were expressed by gingival fibroblasts, the most abundant cell type in the inflamed periodontium. We mapped serum cytokine and chemokine levels from periodontitis subjects and healthy controls. We used multivariate partial least squares (PLS) modeling and identified monocyte chemoattractant ...
Periodontitis: Causes, Risk Factors, and Treatment Periodontitis is the inflammation in the teeth and supporting gums. It is a serious gum disease that can result in gum damage and can even destroy the jaw bone. Periodontitis is caused by certain periodontal bacteria in the form of dental plaque. A layer of bacteria and food debris gets build-up on areas that are hard to reach and hence results in periodontitis. Periodontitis always begins with inflammation of the gums commonly called gingivitis. Sometimes it results in bleeding when you brush your teeth. You might notice a discolored bacterial layer on your teeth, if left untreated may result in chronic diseases or tooth loss. Periodontal Treatment: The key to eliminating the periodontitis is by triggering the diseases through diagnosis. As the disease progress, the teeth can be damaged. Hence, it is necessary that the disease should be treated as early as possible. It is important to remove plaque and associated bacteria to resume dental ...
Many studies have looked at the link between periodontitis and heart disease. While there is not enough evidence to say that periodontitis causes hear
If you are suffering from signs of periodontitis, make sure to visit your dentist promptly for correct therapy. Throughout your see your dental professional will definitely inquire you about the past from your disease. After that the assessment of your teeth and also periodontals is actually being monitored particularly the shade and also the suppleness. Your dental professional would likewise examine your teeth for looseness and also the fitness from your teeth with each other. Mainly, x-ray is actually requested to know if you are actually suffering from bone tissue loss because of periodontitis. Your dental professional would additionally use a gum penetrating in testing for gum illness ...
Treating periodontitis once it occurs can be a complex, debilitating, and frustrating process. If you cherished this posting and you would like to get more facts about https://feathersoundsmiles.com kindly visit the page. The most common practice used to deal with periodontitis is scaling, a method that scrapes tartar and bacteria away from the top layer of the tooth. Root planing, another common technique used to take care of periodontitis, is invasive and painful and needs the smoothing of the outer surfaces of the root of the tooth ...
If you are actually experiencing signs and symptoms of periodontitis, make certain to visit your dentist instantly for effective treatment. Throughout your browse through your dental practitioner will certainly ask you regarding the history from your disease. Then the evaluation from your pearly whites and gum tissues is being actually monitored specifically the different colors as well as the firmness. Your dentist would additionally check your teeth for looseness and also the exercise from your teeth together. Usually, x-ray is asked for to know if you are actually experiencing bone reduction as a result of periodontitis. Your dental expert would certainly likewise utilize a periodontal probing in screening for gum tissue ailments ...
Periodontitis is a bacterial infection that affects the tissues, ligaments and bones that keep our teeth in place. Learn more about periodontitis.
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Periodontitis can almost always be cured. Dedicated preventive routines, along with supplementation and necessary lifestyle changes, can allow your body to rid itself of the infection. Depending on how advanced the condition is you may need professional treatment ranging from maintenance visits to surgical therapies. In extremely advanced stages of the disease it may be impossible, requiring extraction of the teeth to rid the body of the chronic infection.
A major etiologic agent of human periodontal disease. This strain was recovered from the subgingival plaque of a patient diagnosed with generalized aggressive periodontitis ...
A major etiologic agent of human periodontal disease. This strain was recovered from the subgingival plaque of a patient diagnosed with generalized aggressive periodontitis ...
Calcium-dependent protein kinases (CDPKs) constitute a unique family of enzymes in plants that are characterized by a C-terminal calmodulin (CaM)-like domain. Through protein kinase assays, we have examined the levels of cucumber calcium-dependent kinase $(C_SCDPK)$ activity in various organs of cucumber seedlings and plants. The activity of $C_SCDPK$ was highest in cucumber plant leaves followed by seedling roots and hypocotyls; however, cucumber plant flowers, seedling cotyledons, and hooks had levels that were barely detectable. The $C_SCDPKs$ were immunolocalized using polyclonal antibodies that are highly specific against a part of the kinase domain of a calcium-dependent protein kinase $(C_SCDPKS)$ in the phloem sieve elements (SEs) in various organs of cucumber. In addition, this study indicates the presence of CsCDPKs in organelle-like bodies associated with the plasma membrane of sieve elements in mature stems and roots as well as in the storage bodies of immature seeds. These findings ...
By Borrell, Luisa N Burt, Brian A; Neighbors, Harold W; Taylor, George W Objectives. We assessed the prevalences of periodontitis by education and income levels among US adults with data from the third National Health and Nutrition Examination Survey. Methods. The study was limited to non-Hispanic Blacks, Mexican Americans, and non- Hispanic Whites 50 years of age or older with a complete periodontal assessment during the dental examination. Results. Blacks with higher education and income levels had a significantly higher prevalence of periodontitis than their White and Mexican-American counterparts. The relationship between income level and periodontitis was modified by race/ethnicity. High-income Blacks exhibited a higher prevalence of periodontitis than did low- income Blacks and high-income Whites. Conclusions. Our findings call attention to the importance of recognizing socioeconomic status-related health differences across racial/ethnic groups within the social, political, and historical ...
Introduction: Chronic periodontitis (CP) is an infectious disease resulting in the inflammation of the supportive structures of teeth, which leads to loss of attachment and bone, and eventually tooth loss if left untreated. Genetic polymorphisms in the proinflammatory cytokine, interleukin-1 (IL-1A and IL-1B) isoforms have been associated with CP in Caucasians, Asians and Arabs but little is known about their role in Africans. Therefore, the aim of this study was to resolve the association between genetic polymorphisms in IL-1A and IL-1B isoforms and chronic periodontitis in two Kenyan coastal communities, the Taita and the Swahili. Objectives: 1) To determine the association between socio-demographic characteristics, clinical features and CP amongst cases and controls in both ethnic groups. 2) To determine the severity of CP in both ethnic groups. 3) To determine the distribution of interleukin-1 genotype polymorphisms of IL-1Band IL-1A in both ethnic groups. 4) To evaluate the association ...
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Periodontitis, a gum disease present in nearly half of all adults in the United States, involves inflammation, bleeding and bone loss. In its severe form, it is associated with systemic inflammatory conditions such as atherosclerosis and rheumatoid arthritis. Few treatment options exist beyond dental scaling and root planing, done in an attempt to reduce plaque and inflammation.. Now, with findings from a study led by University of Pennsylvania researchers, there is new hope that the disease can be effectively reversed.. ...
Gingivitis, a common and mild form of gum disease can progress to periodontitis, a more serious infection that damages the soft tissue of the gums and sometimes even destroys the bone supporting the teeth.
Periodontitis Is the inflammation of the periodontium (the tissues surrounding the teeth). There are two types: periapical and marginal.
San Francisco, CA (Vocus/PRWEB) February 02, 2011 -- People with severe gum disease (periodontitis) used to have to undergo surgery with a scalpel that
... is the dental clinic in Leeds, UK, specialised in the non surgical treatment of pyorrhoea.
A detailed description of the effect of periodontitis on cardiovascular diseases. Role of periodontal infections in the pathogenesis of cardiovascular diseases.
Definition of periodontitis simplex. Provided by Stedmans medical dictionary and Drugs.com. Includes medical terms and definitions.
What is Periodontitis disease, and how can it hurt you? Find out today and avoid the worst with our WPFD San Antonio Periodontist. Click for more info!
LJP demanded setting up a special fast track court for the speedy time-bound disposal of cases of innocent people from the Muslim community.
The leading dental and oral heathcare site affords access to the AEGIS dental archives, as well as news, product information, and other online-only articles and features.
Spitting blood after brushing your teeth? That could be a sign of a serious gum disease. Get some advice from our Alkali Dental Studio expert.
Periodontitis is an inflammatory response to the commensal oral bacterial flora and represents one of the most prevalent infections in humans. Approximately 90%...
The long-term objectives of this competing renewal are to develop novel therapeutics for periodontitis by inhibiting nuclear factor-kappa B (NF-kB). Periodontit...
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Background Aggregatibacter actinomycetemcomitans is genetically heterogeneous and comprises distinct clonal lineages that may have different virulence potentials. However, limited information of the strain-to-strain genomic variations is available. Methodology/Principal Findings The genome sequences of 11 A. actinomycetemcomitans strains (serotypes a-f) were generated de novo, annotated and combined with three previously sequenced genomes (serotypes a-c) for comparative genomic analysis. Two major groups were identified; serotypes a, d, e, and f, and serotypes b and c. A serotype e strain was found to be distinct from both groups. The size of the pangenome was 3,301 genes, which included 2,034 core genes and 1,267 flexible genes. The number of core genes is estimated to stabilize at 2,060, while the size of the pangenome is estimated to increase by 16 genes with every additional strain sequenced in the future. Within each strain 16.7-29.4% of the genome belonged to the flexible gene pool. Between any
Background Pathological changes in periodontal tissues are mediated by the interaction between microorganisms and the host immune-inflammatory response. Hyperglycemia may interfere with this process. The aim of this study was to compare the levels of 27 inflammatory molecules in the gingival crevicular fluid (GCF) of patients with type 2 diabetes, with and without chronic periodontitis, and of chronic periodontitis subjects without diabetes. A putative correlation between glycated haemoglobin (HbA1c) and levels of the inflammatory molecules was also investigated. Methods The study population comprised a total of 108 individuals, stratified into: 54 with type 2 diabetes and chronic periodontitis (DM + CP), 30 with chronic periodontitis (CP) and 24 with type 2 diabetes (DM). Participants were interviewed with the aid of structured questionnaire. Periodontal parameters (dental plaque, bleeding on probing and periodontal pocket depth) were recorded. The GCF levels of the 27 inflammatory molecules ...
Aggregatibacter actinomycetemcomitans ATCC ® 700685D-5™ Designation: Genomic DNA from Aggregatibacter actinomycetemcomitans strain HK1651 TypeStrain=False Application:
Aggregatibacter actinomycetemcomitans ATCC ® 700685D-5™ Designation: Genomic DNA from Aggregatibacter actinomycetemcomitans strain HK1651 TypeStrain=False Application:
Periodontitis, also known as gum disease and pyorrhea, is a set of inflammatory diseases affecting the tissues surrounding the teeth. Periodontitis involves progressive loss of the alveolar bone around the teeth, and if left untreated, can lead to the loosening and subsequent loss of teeth. Periodontitis is caused by microorganisms that adhere to and grow on the tooths surfaces, along with an over-aggressive immune response against these microorganisms. A diagnosis of periodontitis is established by inspecting the soft gum tissues around the teeth with a probe (i.e., a clinical examination) and by evaluating the patients X-ray films (i.e., a radiographic examination), to determine the amount of bone loss around the teeth. Specialists in the treatment of periodontitis are periodontists; their field is known as "periodontology" or "periodontics". The 1999 classification system for periodontal diseases and conditions listed seven major categories of periodontal diseases, of which 2-6 are termed ...
Adolescent; Aggregatibacter actinomycetemcomitans; Bacterial Toxins; Cohort Studies; Cross-Sectional Studies; DNA, Bacterial; Disease Progression; Ghana; Humans; Pasteurellaceae Infections; Periodontal Diseases ...
Aggregatibacter actinomycetemcomitans GroEL Protein Promotes Conversion of Human CD4 T Cells into IFNγ IL10 Producing Tbet Th1 Cells. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
Author: press release. The bacteria that cause periodontitis, a disease affecting the tissues surrounding the teeth, seems to play a part also in the onset of pancreatic cancer, say the researchers at the University of Helsinki and the Helsinki University Hospital, Finland, and the Karolinska Institutet, Sweden.. The researchers have investigated the role of bacteria causing periodontitis, an inflammation of the tissues surrounding the teeth, in the development of oral cancers and certain other cancers, as well as the link between periodontitis and cancer mortality on the population level.. The study, published in the British Journal of Cancer, has for the first time proven the existence of a mechanism on the molecular level through which the bacteria associated with periodontitis, Treponema denticola (Td), may also have an effect on the onset of cancer. Researchers found that the primary virulence factor of the Td bacteria, the Td-CTLP proteinase (an enzyme), occurs also in malignant tumors of ...
The Porphyromonas gingivalis collagenase-specific serum immunoglobulin A (IgA), IgM, and IgG responses from 20 patients with early-onset periodontitis (EOP), 20 patients with adult periodontitis (AP), and 20 age- and sex- matched healthy controls were examined by immunoblot analysis. A recombinant collagenase antigen used for the immunoblot analysis was produced by using the plasmid pGEX-2T, which allows the fusion between the collagenase and glutathione S-transferase. There was no significant difference in collagenase-specific IgG antibody detection between samples from the EOP, AP, and control groups. In contrast, 85% of AP and EOP sera had collagenase- specific IgA antibodies, whereas only 20% of control sera showed collagenase- specific IgA reactivity. Plaque samples from all groups were assessed by PCR with primers complementary to the collagenase-encoding gene prtC. The results indicated that 90% of AP and EOP plaque samples and 10% of control samples were positive for P. gingivalis. All ...
In Europe, cirrhosis is responsible for 1-2% of all deaths and is the leading cause of liver transplantation.1,2 Periodontitis is a bacterially induced inflammatory disease that affects the supporting tissues of the teeth, characterised by the deepening of periodontal pockets due to loss of connective tissue attachment and bone. Untreated, periodontitis may result in tooth loss. Periodontitis is prevalent in the adult population, with over 35% having periodontitis and 10-15% having severe forms of the disease.3,4 Several studies have assessed the association between periodontitis and cardiovascular diseases, cirrhosis, chronic kidney disease, diabetes mellitus, and respiratory diseases, and an increasing number of studies have suggested that periodontitis may affect the course of systemic diseases.5 Poor oral health and periodontitis are very frequent in patients with cirrhosis.5 In addition, studies have suggested that periodontitis is involved in the progression of liver diseases, and that it ...
Objective: In this study we have assessed the renal and cardiac consequences of ligature-induced periodontitis in both normotensive and nitric oxide (NO)-deficient (L-NAME-treated) hypertensive rats.Materials and methods: Oral L-NAME (or water) treatment was started two weeks prior to induction of periodontitis. Rats were sacrificed 3, 7 or 14 days after ligature placement, and alveolar bone loss was evaluated radiographically. Thiobarbituric reactive species (TBARS; a lipid peroxidation index), protein nitrotyrosine (NT; a marker of protein nitration) and myeloperoxidase activity (MPO; a neutrophil marker) were determined in the heart and kidney.Results: In NO-deficient hypertensive rats, periodontitis-induced alveolar bone loss was significantly diminished. In addition, periodontitis-induced cardiac NT elevation was completely prevented by L-NAME treatment. on the other hand L-NAME treatment enhanced MPO production in both heart and kidneys of rats with periodontitis. No changes due to ...
Histopathological Features of Dental Pulp in Teeth with Different Levels of Chronic Periodontitis Severity. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
Hello, Read your post and wanted to share my fasting experience. I was once over 400 pounds. I yo-yo fast on and off for years but I found when I did it for 23 straight days, I cured some of my ailments that medication could never do. My high blood pressure was gone. I had Uterine Fibroids, gone. I also had, believe it or not, periodontitis disease where I had deep pockets as deep as 9, 10, 11, and 12. I didn t fast to cure that. It s just when I went for my 4 month follow up with my dentist, he was amazed and asked what did I do because he had never seen healing of periodontitis disease. ...
BACKGROUND: Previous studies demonstrated significant variability in the histologic biologic width in periodontal health and mild periodontitis. The purpose of this study was to determine whether the previously established dimensions of the biologic
Egea, J., Fabregat, I., Frapart, Y. M., Ghezzi, P., Görlach, A., Kietzmann, T., Kubaichuk, K., Knaus, U. G., Lopez, M. G., Olaso-Gonzalez, G., Petry, A., Schulz, R., Vina, J., Winyard, P., Abbas, K., Ademowo, S., Afonso, C. B., Andreadou, I., Antelmann, H., Antunes, F., Aslan, M., Bachschmid, M. M., Barbosa, R. M., Belousov, V., Berndt, C., Bernlohr, D., Bertrán, E., Bindoli, A., Bottari, S. P., Brito, P. M., Carrara, G., Casas, A. I., Chatzi, A., Chondrogianni, N., Conrad, M., Cooke, M. S., Costa, J. G., Cuadrado, A., My-Chan Dang, P., De Smet, B., Debelec-butuner, B., Dias, I., Dunn, J. D., Edson, A. J., El Assar, M., El-Benna, J., Ferdinandy, P., Fernandes, A. S., Fladmark, K. E., Förstermann, U., Giniatullin, R., Giricz, Z., Görbe, A., Griffiths, H., Hampl, V., Hanf, A., Herget, J., Hernansanz-Agustín, P., Hillion, M., Huang, J., Ilikay, S., Jansen-Dürr, P., Jaquet, V., Joles, J. A., Kalyanaraman, B., Kaminskyy, D., Karbaschi, M., Kleanthous, M., Klotz, L-O., Korac, B., Korkmaz, K. S., ...
Gingivitis, a common and mild form of gum disease can progress to periodontitis, a more serious infection that damages the soft tissue of the gums and sometimes even destroys the bone supporting the teeth. An international team of researchers and clinicians has charted the microbial ecology of the mouth at all stages of this progression, in nearly 1,000 women in Malawi. This work is laying a foundation of knowledge that could lead to better oral health.
Almost half of adults living in the U.S. age 30 and over have periodontal disease, according to a recent study by researchers from the Centers for Disease Control and Prevention (CDC). The study, published in the Journal of Dental Research, estimates that over 47% of adults, representing 64.7 million adults, had periodontitis-38% of the adult population age 30 and older and 64% of adults age 65 and older had either moderate or severe periodontitis.
Health, ...PHILADELPHIA Periodontitis a form of chronic gum disease that affect...By blocking a molecular receptor that bacteria normally target to caus...The study published in the Journal of Immunology was led by T...In previous research Hajishengallis Lambris and colleagues showed th...,Penn-led,research,suggests,a,new,strategy,to,prevent,or,halt,periodontal,disease,medicine,medical news today,latest medical news,medical newsletters,current medical news,latest medicine news
Abstract The oral mucosa is exposed to a high density and diversity of gram-positive and gram-negative bacteria, but very little is known about how immune homeostasis is maintained..
Patients with periodontitis have higher plasma concentrations of glycated haemoglobin (HbA1c) than people with healthy gums, and those with severe periodontitis have a significantly higher risk of developing diabetes, a Dutch study has found.. Previous studies had indicated an association between oral disease and diabetes, so researchers investigated whether periodontitis could provide a useful warning sign of type 2 diabetes. They studied 313 consecutive patients visiting a university dental clinic … ...
Resultados: Se analizaron 202 (56.7%) informes de pacientes con periodontitis crónica, 139 (39.1%) de periodontitis agresiva y 15 (4.2%) de individuos periodontalmente sanos. La presencia de microorganismos inusuales de tipo entérico fue 36% y la prevalencia de levaduras 7% en las personas con periodontitis. No se encontraron diferencias significantes entre los tres diagnósticos clínicos con respecto a la presencia de microorganismos entéricos y levaduras. La mayor prevalencia de organismos entéricos correspondió a los géneros Klebsiella, Enterobacter y a bacilos Gram negativos no fermentadores. Se encontraron asociaciones estadísticamente significativas entre la presencia o ausencia de microorganismos infrecuentes con la de algunos microorganismos periodontopáticos en los individuos con enfermedad periodontal ...
Philips Oral Healthcare products are designed to aid in the prevention of cavities, plaque and gingivitis. They have not been cleared or approved for the prevention or treatment of periodontitis or other diseases. Emerging research shows that there is an association between periodontitis and certain systemic diseases. A cause and effect relationship has not been established. ...
So I had gum disease when I was like 16 or something. I didnt understand how serious this problem is until I turned 24. It was a nightmare. My teeth had pockets of between 5mm-8mm. Well, thats obviou...
The leading dental and oral heathcare site affords access to the AEGIS dental archives, as well as news, product information, and other online-only articles and features.
Comparative characteristic of morphological changes in periodontal tissues of animals with different types of inflammatory reactions in case of periodontitis under toxic effect of adrenaline on the early stages of ...
Looking for online definition of Actinobacillus actinomycetemcomitans in the Medical Dictionary? Actinobacillus actinomycetemcomitans explanation free. What is Actinobacillus actinomycetemcomitans? Meaning of Actinobacillus actinomycetemcomitans medical term. What does Actinobacillus actinomycetemcomitans mean?
Oral malodour on awakening is common and generally not regarded as halitosis. Longstanding oral malodour is usually caused by oral, or sometimes nasopharyngeal, disease (box 1). The most likely cause of oral malodour is the accumulation of food debris and dental bacterial plaque on the teeth and tongue, resulting from poor oral hygiene and resultant gingival (gingivitis) and periodontal (gingivitis/periodontitis) inflammation. Although most types of gingivitis and periodontitis can give rise to malodour, acute necrotising ulcerative gingivitis (Vincents disease, trench mouth) causes the most notable halitosis. Adult periodontitis, characterised by gradual plaque related loss of periodontal attachment, can cause variable degrees of oral malodour.2 Aggressive periodontitis, typified by rapid loss of periodontal bone and resultant tooth mobility, can cause intense oral malodour.. Lack of oral cleansing because of xerostomia (dryness of the mouth) also has the potential to cause or enhance ...
Signs of gingivitis and periodontitis (periodontal disease). Healthy gum tissue is characterized by its light pink color. The inter-dental spaces are completely filled and do not bleed when touched. The first signs of gum tissue disease most often are bleeding of the gums and halitosis, the gum tissue is red and swollen. This stage is called gingivitis, which can develop into periodontitis or periodontal disease if left untreated. The signs of periodontitis or periodontal disease are receding gums (gum tissue and bone recedes), longer tooth necks (teeth appear to be longer), damage to the entire periodontium, inflammation of the gums as well as loosening of teeth and in the end loss of teeth. Periodontitis rarely causes pain and the course is often slow and insidious. However, there are some specific forms of this disease that have a very aggressive course. In order to stop periodontitis early on, it is important to take the initial signs very seriously and have them treated by your dentist. ...
Periodontal pathology, also termed gum diseases or periodontal diseases, are diseases involving the periodontium (the tooth supporting structures, i.e. the gums). The periodontium is composed of alveolar bone, periodontal ligament, cementum and gingiva. An internationally agreed classification formulated at the World Workshop in Clinical Periodontics in 1989 divided periodontal diseases into 5 groups: adult periodontitis, early-onset periodontitis, periodontitis associated with systemic disease, necrotizing ulcerative peirodontitis and refactory periodontitis. In 1993 at the 1st European Workshop in Periodontology the earlier classification was simplified and the categories periodontitis associated with systemic disease and refractory periodontitis were dropped. Both of these classification systems were widely used in clinical and research settings. However, they failed to address a gingival disease component, had overlapping categories with unclear classification criteria and over focussed on ...
The ability to selectively target specific biofilm species with antimicrobials would enable control over biofilm consortium composition, with medical applications in treatment of infections on mucosal surfaces that are colonized by a mixture of beneficial and pathogenic microorganisms. We functionalized a genetically engineered multimeric protein with both a targeting moiety (biotin) and either a fluorophore or a photosensitizer (SnCe6). Biofilm microcolonies of Aggregatibacter actinomycetemcomitans, a periodontal pathogen, were targeted with the multifunctional dodecamer. Streptavidin was used to couple biotinylated dodecamer to a biotinylated anti-A. actinomycetemcomitans antibody. This modular targeting approach enabled us to increase the loading of photosensitizer onto the cells by a cycle of amplification. Scanning laser confocal microscopy was used to characterize transport of fluorescently tagged dodecamer into the microcolonies and targeting of the cells with biotin-labeled, ...
Periodontitis (pair-e-o-don-TI-tis) may be a serious gum infection that destroys the soft tissue and bone that support your teeth and endodontics is focused on the detection and treatment of pulp diseases as well. Disease will cause tooth loss or worse, associate with nursing inflated risk of heart failure or stroke and different serious health issues. Endodontics or periodontitis is however common for the most parts preventable. Disease is sometimes the result of poor oral hygiene. Daily brushing and flossing and regular skilled dental cleanings will greatly cut back your probability of developing disease. The purpose of the current review is to explore the important role for periodontitis/endodontics prevention in oral hygiene and health as well. In this review periodontitis/endodontics will be discussed in details in all aspects.
Amaliya, Timmerman MF, Abbas F, Loos BG, Van der Weijden GA, Van Winkelhoff AJ, et al. Java project on periodontal diseases: the relationship between vitamin C and the severity of periodontitis. J Clin Periodontol. 2007 Apr;34(4):299-304.. Boggess KA; Society for Maternal-Fetal Medicine Publications Committee. Maternal oral health in pregnancy. Obstet Gynecol. 2008 Apr;111(4):976-86.. Eberhard J, Jepsen S, Jervøe-Storm PM, Needleman I, Worthington HV. Full-mouth disinfection for the treatment of adult chronic periodontitis. Cochrane Database Syst Rev. 2008 Jan 23;(1):CD004622.. Eberhard J, Jervøe-Storm PM, Needleman I, Worthington H, Jepsen S. Full-mouth treatment concepts for chronic periodontitis: a systematic review. J Clin Periodontol. 2008 Jul;35(7):591-604. Epub 2008 May 21.. Friedewald VE, Kornman KS, Beck JD, Genco R, Goldfine A, Libby P, et al. The American Journal of Cardiology and Journal of Periodontology Editors Consensus: periodontitis and atherosclerotic cardiovascular disease. ...
Looking for Private Periodontitis Treatment? Choose from 51 Private Periodontitis Treatment Clinics in Manchester, Lancashire. Compare prices, read reviews and get quotes.
Sockett and Lambert, 2004. Balos are ubiquitous in nature and have been isolated from diverse terrestrial and aquatic habitats, from biofilms as well as from animal feces
Find information about gingivitis, gum disease, and periodontitis from Cleveland Clinic, including causes, symptoms, treatment, and prevention.
Methods: The study included 88 subjects assigned to four groups of 22 subjects each, as follows: O+CP+ (patients with obesity and periodontitis); O P+ (patients with normal weight and periodontitis); O+P (periodontally healthy patients with obesity); and the control group consisting of periodontally healthy patients with normal weight (O P ). Serum and salivary samples were obtained a week before the recording of clinical periodontal parameters. Local and systemic TOS and TAS levels were determined biochemically ...
Looking for apical periodontitis? Find out information about apical periodontitis. Inflammation of the periodontium. an acute or chronic inflammation of the periodontium and adjacent tissues. Periodontitis is usually a result of dental... Explanation of apical periodontitis
This multicenter clinical study will investigate biomarkers of periodontal disease progression. The study will enroll 375 subjects with periodontal disease and 125 periodontally healthy subjects. All subjects will be monitored clinically and have samples taken every 2 months for 12 months for analysis of inflammatory and immunological biomarkers and microbial species. Subjects displaying periodontal disease progression greater than an established threshold will receive periodontal rescue therapy at progressing periodontal sites and continue with monitoring. Periodontally healthy subjects and non-progressing sites in subjects with periodontal disease will serve as controls. After 12 months, subjects with periodontal disease will receive periodontal therapy consisting of 4 quadrants of scaling and root planing. Periodontally healthy subjects will receive prophylaxis and scaling and exit the study. Following periodontal therapy, subjects with periodontal disease will be followed for a maintenance ...
Periodontitis is a chronic inflammatory disease caused by exaggerated host immune responses to dysregulated microbiota in dental biofilms leading to degradation of tissues and alveolar bone loss. Porphyromonas gingivalis is a major periodontal pathogen and expresses several potent virulence factors. Among these factors, arginine and lysine gingipains are of special importance, both for the bacterial survival/proliferation and the pathological outcome. The major aim of this thesis was to develop and test novel methods for diagnosis and prevention of P. gingivalis infection and periodontitis. In study I, anti-P. gingivalis antibodies were developed in vitro for immunodetection of bacteria in clinical samples using a surface plasmon resonance (SPR)-based biosensor. Specific binding of the antibodies to P. gingivalis was demonstrated in samples of patients with periodontitis and the results were validated using real-time PCR and DNA-DNA checkerboard analysis. In study II, we elucidated the ...
Aim We investigated the association between angiographically verified coronary artery disease (CAD) and subgingival Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Tannerella forsythia and Treponema denticola. Materials and Methods The cross-sectional study population (n = 445) comprised 171 (38.4%) patients with Stable CAD, 158 (35.5%) with acute coronary syndrome (ACS) and 116 (26.1%) with no significant CAD (No CAD). All patients participated in clinical and radiological oral health examinations. Pooled subgingival bacterial samples were analysed by checkerboard DNA-DNA hybridization assays. Results In all study groups, the presence of P. gingivalis, T. forsythia and T. denticola indicated a significant (p ≤ 0.001) linear association with the extent of alveolar bone loss (ABL), but A. actinomycetemcomitans did not (p = 0.074). With a threshold level of bacterial cells 1 × 105 A. actinomycetemcomitans was significantly more prevalent in the Stable CAD group (42.1%) compared ...

generalized aggressive periodontitisgeneralized aggressive periodontitis

... chronic periodontitis, generalized aggressive periodontitis, Gum Disease, localized aggressive periodontitis, Periodontitis, ... This entry was posted in Gum Disease, Periodontics and tagged aggressive periodontitis, aggressive periodontitis treatment, ... with aggressive periodontitis commonly seen in the younger age group. Continue reading → ... Periodontitis (inflammation of the supporting tissues of the teeth or also known as the periodontium) can also occur in young ...
more infohttp://www.intelligentdental.com/tag/generalized-aggressive-periodontitis/

Prevalence analysis of putative periodontal pathogens in patients with aggressive periodontitis and healthy elderlyPrevalence analysis of putative periodontal pathogens in patients with aggressive periodontitis and healthy elderly

No direct association for P. intermedia and E. corrodens with aggressive periodontitis or periodontal health could be seen. A. ... These putative pathogens can be conclusively determined as the key-bacteria in patients with aggressive periodontitis. ... research was to analyze the prevalence of periodontitis-associated microorganisms in patients with aggressive periodontitis and ... subgingival plaque was sampled from four pockets and one healthy site of 45 aggressive periodontitis patients as well as from ...
more infohttps://edoc.hu-berlin.de/handle/18452/16028

aggressive periodontitisaggressive periodontitis

Periodontitis is common, but aggressive periodontitis (AgP) is thought to progress faster than chronic periodontitis (CP). ... Tagged with: aggressive periodontitis, chemokines, chronic periodontitis, cytokines, periodontal disease. Dental Implants : ... Tagged with: aggressive periodontitis, antibiotics, chronic periodontitis, diabetes, doxycycline, HbA1c, periodontal disease, ... Tagged with: aggressive periodontitis, chronic periodontitis, clinical attachment level, periodontal disease, pocket depth, ...
more infohttps://www.nationalelfservice.net/tag/aggressive-periodontitis/

Treatment of aggressive periodontitis - Page 3Treatment of aggressive periodontitis - Page 3

... that chronic periodontitis may occur simultaneously with both localized and generalized forms of aggressive periodontitis ... Surgical treatment of aggressive periodontitis The diagnosis of aggressive periodontitis is often made at an advanced stage of ... In summary, age, educational status, generalized aggressive periodontitis (vs. localized aggressive periodontitis), absence of ... The type of aggressive periodontitis was a nearly significant risk factor for which patients with generalized aggressive ...
more infohttp://dentisty.org/treatment-of-aggressive-periodontitis.html?page=3

ANTIMICROBIAL AND ANTIBIOFILM ACTIVITY OF CATHELICIDINS - Patent applicationANTIMICROBIAL AND ANTIBIOFILM ACTIVITY OF CATHELICIDINS - Patent application

... loss of the alveolar bone and a disease known as localized aggressive periodontitis (LAP) (8). In addition, colonization by A. ... 0182] (18) Paju S, Scannapieco F A. Oral biofilms, periodontitis, and pulmonary infections. Oral diseases 2007:13:508-512. [ ... 0174] (10) Wisner-Lynch L A, Giannobile W V. Current concepts in juvenile periodontitis. Current opinion in periodontology 1993 ... periodontitis. A. actinomycetemcomitans is a facultative anaerobe that grows best in an aerobic environment enriched with ...
more infohttp://www.patentsencyclopedia.com/app/20120149631

Cytotoxic mechanisms of Aggregatibacter actinomycetemcomitans leukotoxin - Angela BrownCytotoxic mechanisms of Aggregatibacter actinomycetemcomitans leukotoxin - Angela Brown

Aggregatibacter actinomycetemcomitans is a Gram-negative pathogen that is the etiologic agent of localized aggressive ... actinomycetemcomitans is a Gram-negative pathogen that is the etiologic agent of localized aggressive periodontitis (LAP) and ...
more infohttp://grantome.com/grant/NIH/R00-DE022795-03

Signs & Symptoms of Periodontal DiseaseSigns & Symptoms of Periodontal Disease

There are many common types of periodontal disease including aggressive, chronic, necrotizing periodontitis, and periodontitis ... Severe periodontitis can be treated in several different ways, such as:. * Laser treatment - This can be used to reduce the ... Loose teeth/change in bite pattern - A sign of rapidly progressing periodontitis is the loosening or shifting of the teeth in ... Periodontal disease (also known as periodontitis and gum disease) is a progressive condition and the leading cause of tooth ...
more infohttp://www.elkhornfamilydental.net/services/periodontal-disease/signs-symptoms-of-periodontal-disease/

Signs & Symptoms of Periodontal DiseaseSigns & Symptoms of Periodontal Disease

There are many common types of periodontal disease including aggressive, chronic, necrotizing periodontitis, and periodontitis ... Severe periodontitis can be treated in several different ways, such as:. * Laser treatment - This can be used to reduce the ... Loose teeth/change in bite pattern - A sign of rapidly progressing periodontitis is the loosening or shifting of the teeth in ... Periodontal disease (also known as periodontitis and gum disease) is a progressive condition and the leading cause of tooth ...
more infohttp://www.centralparkcosmeticdmd.com/procedures/periodontal-disease/signs-symptoms-of-periodontal-disease/

Aggressive periodontitis - WikipediaAggressive periodontitis - Wikipedia

Localized aggressive periodontitis (LAP) Generalized aggressive periodontitis (GAP) Aggressive periodontitis is much less ... Aggressive periodontitis runs in the patients family. Familial aggregation of aggressive periodontitis is often discovered by ... Aggressive periodontitis describes a type of periodontal disease and includes two of the seven classifications of periodontitis ... aggressive periodontitis was defined according to 3 primary features, in contrast to chronic periodontitis. These features are ...
more infohttps://en.wikipedia.org/wiki/Aggressive_periodontitis

Treatment of a Periodontic-Endodontic Lesion in a Patient with Aggressive PeriodontitisTreatment of a Periodontic-Endodontic Lesion in a Patient with Aggressive Periodontitis

... Mina D. Fahmy,1 Paul G. Luepke,1 ... "Retention of questionable and hopeless teeth in compliant patients treated for aggressive periodontitis," Journal of Clinical ... M. Simring and M. Goldberg, "The pulpal pocket approach: retrograde periodontitis," Journal of Periodontology, vol. 35, no. 1, ... G. Matuliene, B. E. Pjetursson, G. E. Salvi et al., "Influence of residual pockets on progression of periodontitis and tooth ...
more infohttps://www.hindawi.com/journals/crid/2016/7080781/ref/

Mechanisms and Treatment Response of Aggressive Periodontitis in Children - Tabular View - ClinicalTrials.govMechanisms and Treatment Response of Aggressive Periodontitis in Children - Tabular View - ClinicalTrials.gov

Mechanisms and Treatment Response of Aggressive Periodontitis in Children. The safety and scientific validity of this study is ... Aggressive Periodontitis. Intervention ICMJE *Procedure: Diseased periodontal treatment Treatment includes scaling and root ... Diagnosed with localized aggressive periodontitis (LAP), defined by the presence of attachment loss ≥ 2mm and detected bone ... Mechanisms and Treatment Response of Aggressive Periodontitis in Children. Official Title ICMJE Mechanisms and Treatment ...
more infohttps://www.clinicaltrials.gov/ct2/show/record/NCT01330719?term=gum+disease&fund=0&rank=26

Mechanisms and Treatment Response of Aggressive Periodontitis in Children - Full Text View - ClinicalTrials.govMechanisms and Treatment Response of Aggressive Periodontitis in Children - Full Text View - ClinicalTrials.gov

Periodontitis. Aggression. Aggressive Periodontitis. Periodontal Diseases. Mouth Diseases. Stomatognathic Diseases. Behavioral ... Mechanisms and Treatment Response of Aggressive Periodontitis in Children. The safety and scientific validity of this study is ... Aggressive Periodontitis Procedure: Diseased periodontal treatment Procedure: Conventional periodontal treatment Not Applicable ... Diagnosed with localized aggressive periodontitis (LAP), defined by the presence of attachment loss ≥ 2mm and detected bone ...
more infohttps://www.clinicaltrials.gov/ct2/show/NCT01330719?term=gum+disease+AND+oral&fund=0&rank=43

Aggressive periodontitis Flashcards by asw asw | BrainscapeAggressive periodontitis Flashcards by asw asw | Brainscape

T/F: localized aggressive periodontitis seems to have a strong link to genetics ... if more than ______ teeth are affected by aggressive periodontitis, it is considered generalized ... which immunoglobulin seems to play a critical role in LOCALIZED aggressive periodontitis? ... when diagnosing aggressive perio, having no history of _______ disease or ________ infections is a critical sign ...
more infohttps://www.brainscape.com/flashcards/aggressive-periodontitis-2909068/packs/4766146

Subgingival microbiome in Chinese patients with generalized aggressive periodontitis compared to healthy controls.  - PubMed -...Subgingival microbiome in Chinese patients with generalized aggressive periodontitis compared to healthy controls. - PubMed -...

Subgingival microbiome in Chinese patients with generalized aggressive periodontitis compared to healthy controls.. Cui X1, Liu ... The aim of the study was to profile the subgingival microbiome of Chinese adults with generalized aggressive periodontitis ( ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/30909081

A 3  UTR transition within DEFB1 is associated with chronic and aggressive periodontitisA 3 ' UTR transition within DEFB1 is associated with chronic and aggressive periodontitis

... chronic periodontitis (odds ratio=2.2 (95% confidence interval: 1.16-4.35), P=0.02), and aggressive periodontitis (odds ratio= ... A 3 UTR transition within DEFB1 is associated with chronic and aggressive periodontitis. Journal. Genes and Immunity. Pages ( ... of the immune system toward microbial pathogens is considered as the key factor in the development of periodontitis. Defensins ... The association was consistent with the specific periodontitis forms: ...
more infohttp://dare.uva.nl/search?metis.record.id=325702

Paper: Comprehensive Microbiological Characterization in Children with Localized Aggressive Periodontitis (AADR Annual Meeting ...Paper: Comprehensive Microbiological Characterization in Children with Localized Aggressive Periodontitis (AADR Annual Meeting ...

Objective: We have identified a group of African-American children with localized Aggressive Periodontitis (LAP) within one ... 748 Comprehensive Microbiological Characterization in Children with Localized Aggressive Periodontitis Friday, March 23, 2012: ...
more infohttp://www-personal.umich.edu/~sbayne/DMG/DMG-Publications/IADR-AADR-Meeting-Program-Books/2012-AADR-Tampa/2012-AADR-Tampa-CD/AADR12/Paper157027.html

Microbiological profile of early onset/aggressive periodontitis patients.  - Zurich Open Repository and ArchiveMicrobiological profile of early onset/aggressive periodontitis patients. - Zurich Open Repository and Archive

Kamma, J J; Nakou, M; Gmür, R; Baehni, P C (2004). Microbiological profile of early onset/aggressive periodontitis patients. ... CONCLUSIONS: The microbial profile of the early onset/aggressive periodontitis population was complex. The agreement between ... CONCLUSIONS: The microbial profile of the early onset/aggressive periodontitis population was complex. The agreement between ... and to seek possible bacterial associations in the subgingival microbiota of early onset periodontitis/aggressive periodontitis ...
more infohttps://www.zora.uzh.ch/id/eprint/1630/

GC Gene Polymorphisms and Vitamin D-Binding Protein Levels Are Related to the Risk of Generalized Aggressive PeriodontitisGC Gene Polymorphisms and Vitamin D-Binding Protein Levels Are Related to the Risk of Generalized Aggressive Periodontitis

... ... "GC Gene Polymorphisms and Vitamin D-Binding Protein Levels Are Related to the Risk of Generalized Aggressive Periodontitis," ...
more infohttps://www.hindawi.com/journals/ije/2016/5141089/cta/

The Affect of Orthodontic Treatment on the Periodontal Status of Patients With Aggressive Periodontitis - Full Text View -...The Affect of Orthodontic Treatment on the Periodontal Status of Patients With Aggressive Periodontitis - Full Text View -...

aggressive Periodontitis Aggressive Periodontitis during maintenance. Procedure: orthodontic treatment Patients with Aggressive ... aggressive periodontitis aggressive periodontitis patients during maintenance. Procedure: orthodontic treatment Patients with ... Periodontitis. Aggression. Aggressive Periodontitis. Periodontal Diseases. Mouth Diseases. Stomatognathic Diseases. Behavioral ... The Affect of Orthodontic Treatment on the Periodontal Status of Patients With Aggressive Periodontitis. The safety and ...
more infohttps://clinicaltrials.gov/ct2/show/NCT01510808?term=orthodontic&recr=Open&rank=13

Triclosan as Adjunctive Therapy in the Plaque Control in Children From Generalized Aggressive Periodontitis Families. - Full...Triclosan as Adjunctive Therapy in the Plaque Control in Children From Generalized Aggressive Periodontitis Families. - Full...

Aggressive Periodontitis. Anti-Infective Agents, Local. Periodontitis. Aggression. Periodontal Diseases. Mouth Diseases. ... Triclosan as Adjunctive Therapy in the Plaque Control in Children From Generalized Aggressive Periodontitis Families.. The ... Generalized aggressive periodontitis (GAP) is an inflammatory disease that causes the severe and rapid destruction of ... Triclosan as Adjunctive Therapy in the Plaque Control in Children From Generalized Aggressive Periodontitis Families. A ...
more infohttps://clinicaltrials.gov/ct2/show/NCT03642353?cond=%22Acute+Pericementitis%22&intr=%22Anti-Infective+Agents%2C+Local%22&rank=1

Human leukocyte antigen associations and c-reactive protein levels in lebanese patients with aggressive periodontitis-HLA and...Human leukocyte antigen associations and c-reactive protein levels in lebanese patients with aggressive periodontitis-HLA and...

... didate genetic risk markers for periodontitis. Addi- tionally, periodontitis appears to contribute to the severity of some ... It has been classified into chronic (CP) or ag- gressive (AP) periodontitis according to disease onset, localization and ... and c-reactive protein levels in lebanese patients with aggressive periodontitis-HLA and CRP in aggressive periodontitis. Open ... and c-reactive protein levels in lebanese patients with aggressive periodontitis-HLA and CRP in aggressive periodontitis ...
more infohttp://www.scirp.org/journal/PaperInformation.aspx?PaperID=5698

RePub, Erasmus University Repository:
  A haplotype block downstream of plasminogen is associated with chronic and aggressive...RePub, Erasmus University Repository: A haplotype block downstream of plasminogen is associated with chronic and aggressive...

Aggressive periodontitis, Chronic periodontitis, Genetic association, Plasmin, Plasminogen, Rs1247559, Rs4252120 Persistent URL ... A haplotype block downstream of plasminogen is associated with chronic and aggressive periodontitis. Publication. Publication. ... Aim: The intronic variant rs4252120 in the plasminogen gene (PLG) is known to be associated with aggressive periodontitis (AgP ... A haplotype block downstream of plasminogen is associated with chronic and aggressive periodontitis. Journal of Clinical ...
more infohttps://repub.eur.nl/pub/101950

NADPH oxidase (CYBA) and FcgammaR polymorphisms as risk factors for aggressive periodontitis: a case-control association study....NADPH oxidase (CYBA) and FcgammaR polymorphisms as risk factors for aggressive periodontitis: a case-control association study....

... in aggressive periodontitis (AgP) patients have been reported to be hyperactive especially with regards to superoxide ... Classification and diagnosis of aggressive periodontitis.. Daniel H Fine, Amey Patil, Bruno G. Loos ... Classification and diagnosis of aggressive periodontitis.. Daniel H Fine, Amey Patil, Bruno G. Loos ... Association between interleukin-6 promoter haplotypes and aggressive periodontitis.. Luigi Nibali, Gareth Steven Fredericton ...
more infohttps://www.semanticscholar.org/paper/NADPH-oxidase-
  • Systemic antibiotics for aggressive periodontitis? (nationalelfservice.net)
  • This review of systemic antibiotics and non-surgical periodontal therapy for aggressive periodontitis included 13 RCTs and suggests a statistically significant benefit compared to non-surgical therapy alone. (nationalelfservice.net)
  • This review and network meta-analysis included 11 small RCTs of limited quality, suggesting a statistically significant benefit for the use of adjunctive systemic antibiotics for the treatment of aggressive periodontitis. (nationalelfservice.net)
  • This review looked at the effectiveness of antimicrobial photodynamic therapy as an adjunctive treatment to scaling and root polishing for aggressive periodontitis. (nationalelfservice.net)
  • The investigators are testing oral subgingival microbiota using Homin microarray analysis to detect ~300 bacterial species in aggressive periodontitis children compared to healthy siblings and unrelated controls. (clinicaltrials.gov)
  • BACKGROUND Differences in the composition of subgingival microbiota in periodontitis have been observed in different geographic locations. (semanticscholar.org)
  • Capnocytophaga spp are implicated as prime periodontal pathogens, especially in localised aggressive periodontitis. (wikipedia.org)
  • The aim of the study was to profile the subgingival microbiome of Chinese adults with generalized aggressive periodontitis (GAgP) using human oral microbe identification microarray (HOMIM), and to compare the results with matched periodontal healthy controls. (nih.gov)
  • For that reason non-RA individuals who suffered from generalized aggressive (GAgP, N = 51) and generalized chronic periodontitis (GChP, N = 50) were investigated regarding the occurrence of antibodies against citrullinated cyclic peptides (anti-CCP) and citrullinated α-enolase peptide-1 (anti-CEP-1) in comparison to non-RA non-periodontitis controls (N = 89). (biomedcentral.com)
  • A young female patient suffering from achondroplasia reported with oral manifestations showing features of aggressive periodontitis, hypoplasia of the mid‑face, clinical attachment loss, and mobility of teeth. (journalcra.com)
  • This review looked at the effectiveness of antimicrobial photodynamic therapy as an adjunctive treatment to scaling and root polishing for aggressive periodontitis. (nationalelfservice.net)
  • Herrera D, Alonso B, León R, Roldán S, Sans M. Antimicrobial therapy in periodontitis:the use of systemic antimicrobials againstthe subgingival biofilm. (balkandentaljournal.com)
  • Methods: 263 subjects were diagnosed with aggressive periodontitis. (pitt.edu)
  • Aim The aim of the study was to compare two methods of treatment for aggressive periodontitis: traditional surgical and Nd:YAG laser, evaluating their possible objective clinical advantages. (univaq.it)
  • This review and network meta-analysis included 11 small RCTs of limited quality, suggesting a statistically significant benefit for the use of adjunctive systemic antibiotics for the treatment of aggressive periodontitis. (nationalelfservice.net)
  • Kaner D, Chirstan C, Deitrich T, Bernimoulin JP, Kleber BM, Friedmann A. Timing affect the clinical outcome of adjunctive systemic antibiotic therapy for generalized aggressive periodontitis. (balkandentaljournal.com)
  • Treatment of generalized aggressive periodontitis with FRP alone or FRP combined with systemic antibiotics provided significant clinical benefits that reduced the need for periodontal surgery. (jcda.ca)
  • Systemic antibiotics for aggressive periodontitis? (nationalelfservice.net)
  • This review of systemic antibiotics and non-surgical periodontal therapy for aggressive periodontitis included 13 RCTs and suggests a statistically significant benefit compared to non-surgical therapy alone. (nationalelfservice.net)
  • Adult periodontitis affects less than 10 to 15% of the population in industrialized countries, mainly adults around the ages of 50 to 60. (wikipedia.org)
  • Conclusion: The frequency BRINP3 is higher in aggressive periodontitis compared with healthy cases in Arab population. (pitt.edu)
  • what are the overall characteristics of aggressive periodontitis? (brainscape.com)
  • 57 Aggressive periodontitis, which may be generalized or localized, is characterized by severe and protracted gingival infections, leading to tooth loss. (malacards.org)
  • Aim: The intronic variant rs4252120 in the plasminogen gene (PLG) is known to be associated with aggressive periodontitis (AgP) and atherosclerosis. (eur.nl)
  • An important gene associated with Periodontitis, Aggressive, 1 is CTSC (Cathepsin C), and among its related pathways/superpathways is Lysosome . (malacards.org)
  • Based on this result, BRINP3 gene is associated with aggressive periodontists. (pitt.edu)
  • If risk factors, such as smoking, can be controlled , the level of maintenance therapy is high and the patient is compliant, the outcome of periodontal surgery in aggressive periodontitis can be comparable with that in chronic periodontitis. (dentisty.org)
  • Triclosan as Adjunctive Therapy in the Plaque Control in Children From Generalized Aggressive Periodontitis Families. (clinicaltrials.gov)
  • NADPH oxidase (CYBA) and FcgammaR polymorphisms as risk factors for aggressive periodontitis: a case-control association study. (semanticscholar.org)