Aggregatibacter actinomycetemcomitans
Pasteurellaceae
Aggressive Periodontitis
Inflammation and loss of PERIODONTIUM that is characterized by rapid attachment loss and bone destruction in the presence of little local factors such as DENTAL PLAQUE and DENTAL CALCULUS. This highly destructive form of periodontitis often occurs in young people and was called early-onset periodontitis, but this disease also appears in old people.
Actinobacillus
Exotoxins
Periodontitis
Inflammation and loss of connective tissues supporting or surrounding the teeth. This may involve any part of the PERIODONTIUM. Periodontitis is currently classified by disease progression (CHRONIC PERIODONTITIS; AGGRESSIVE PERIODONTITIS) instead of age of onset. (From 1999 International Workshop for a Classification of Periodontal Diseases and Conditions, American Academy of Periodontology)
Chronic Periodontitis
Campylobacter rectus
Periodontal Pocket
Periodontal Diseases
Dental Plaque
Gingival Hemorrhage
Treponema denticola
Fusobacterium nucleatum
Prevotella intermedia
Porphyromonas gingivalis
Dental Devices, Home Care
Biofilms
Encrustations, formed from microbes (bacteria, algae, fungi, plankton, or protozoa) embedding in extracellular polymers, that adhere to surfaces such as teeth (DENTAL DEPOSITS); PROSTHESES AND IMPLANTS; and catheters. Biofilms are prevented from forming by treating surfaces with DENTIFRICES; DISINFECTANTS; ANTI-INFECTIVE AGENTS; and antifouling agents.
Periodontium
Peri-Implantitis
Alveolar Bone Loss
Aggregatibacter
Bacterial Toxins
Streptococcus gordonii
Periodontal Index
Adhesins, Bacterial
Cell-surface components or appendages of bacteria that facilitate adhesion (BACTERIAL ADHESION) to other cells or to inanimate surfaces. Most fimbriae (FIMBRIAE, BACTERIAL) of gram-negative bacteria function as adhesins, but in many cases it is a minor subunit protein at the tip of the fimbriae that is the actual adhesin. In gram-positive bacteria, a protein or polysaccharide surface layer serves as the specific adhesin. What is sometimes called polymeric adhesin (BIOFILMS) is distinct from protein adhesin.
Aggregatibacter segnis
Mouth
Gingival Crevicular Fluid
A fluid occurring in minute amounts in the gingival crevice, believed by some authorities to be an inflammatory exudate and by others to cleanse material from the crevice, containing sticky plasma proteins which improve adhesions of the epithelial attachment, have antimicrobial properties, and exert antibody activity. (From Jablonski, Illustrated Dictionary of Dentistry, 1982)
Periodontal Attachment Loss
Loss or destruction of periodontal tissue caused by periodontitis or other destructive periodontal diseases or by injury during instrumentation. Attachment refers to the periodontal ligament which attaches to the alveolar bone. It has been hypothesized that treatment of the underlying periodontal disease and the seeding of periodontal ligament cells enable the creating of new attachment.
Aggregatibacter aphrophilus
Bacterial Adhesion
Bacteroides
Gene Expression Regulation, Bacterial
Haemophilus
Virulence Factors
Those components of an organism that determine its capacity to cause disease but are not required for its viability per se. Two classes have been characterized: TOXINS, BIOLOGICAL and surface adhesion molecules that effect the ability of the microorganism to invade and colonize a host. (From Davis et al., Microbiology, 4th ed. p486)
Gram-Negative Bacteria
Epithelial Cells
Cells that line the inner and outer surfaces of the body by forming cellular layers (EPITHELIUM) or masses. Epithelial cells lining the SKIN; the MOUTH; the NOSE; and the ANAL CANAL derive from ectoderm; those lining the RESPIRATORY SYSTEM and the DIGESTIVE SYSTEM derive from endoderm; others (CARDIOVASCULAR SYSTEM and LYMPHATIC SYSTEM) derive from mesoderm. Epithelial cells can be classified mainly by cell shape and function into squamous, glandular and transitional epithelial cells.
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Polymerase Chain Reaction
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
Haemophilus somnus
Identification of a cytolethal distending toxin gene locus and features of a virulence-associated region in Actinobacillus actinomycetemcomitans. (1/397)
A genetic locus for a cytolethal distending toxin (CDT) was identified in a polymorphic region of the chromosome of Actinobacillus actinomycetemcomitans, a predominant oral pathogen. The locus was comprised of three open reading frames (ORFs) that had significant amino acid sequence similarity and more than 90% sequence identity to the cdtABC genes of some pathogenic Escherichia coli strains and Haemophilus ducreyi, respectively. Sonic extracts from recombinant E. coli, containing the A. actinomycetemcomitans ORFs, caused the distension and killing of Chinese hamster ovary cells characteristic of a CDT. Monoclonal antibodies made reactive with the CdtA, CdtB, and CdtC proteins of H. ducreyi recognized the corresponding gene products from the recombinant strain. CDT-like activities were no longer expressed by the recombinant strain when an OmegaKan-2 interposon was inserted into the cdtA and cdtB genes. Expression of the CDT-like activities in A. actinomycetemcomitans was strain specific. Naturally occurring expression-negative strains had large deletions within the region of the cdt locus. The cdtABC genes were flanked by an ORF (virulence plasmid protein), a partial ORF (integrase), and DNA sequences (bacteriophage integration site) characteristic of virulence-associated regions. These results provide evidence for a functional CDT in a human oral pathogen. (+info)Actinobacillus actinomycetemcomitans immunosuppressive protein is a member of the family of cytolethal distending toxins capable of causing a G2 arrest in human T cells. (2/397)
We have previously shown that Actinobacillus actinomycetecomitans produces an immunosuppressive factor (ISF) capable of impairing human lymphocyte function by perturbing cell cycle progression. We now report that ISF is the product of the cdtB gene, one of three genes encoding the family of cytolethal distending toxins (Cdt). The ISF polypeptide exhibits >/=95% identity with Hemophilus ducreyi CdtB protein and +info)Identification and molecular analysis of rough-colony-specific outer membrane proteins of Actinobacillus actinomycetemcomitans. (3/397)
Actinobacillus actinomycetemcomitans, a gram-negative bacterium isolated from the human mouth, has been implicated in the pathogenesis of early-onset periodontitis. Primary isolates cultured from subgingival plaque exhibit an adherent, rough colony phenotype which spontaneously converts to a nonadherent, smooth phenotype upon in vitro subculture. The rough colony variant produces abundant fimbriae and autoaggregates, while the smooth colony variant is planktonic and produces scant fimbriae. To begin to understand the significance of colony variation in biofilm formation by A. actinomycetemcomitans, outer membrane protein profiles of four isogenic rough and smooth colony variants were compared by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Two proteins with relative molecular masses of 43 and 20 kDa were expressed by the rough colony variants exclusively. Expression of these proteins was not found to be dependent on growth phase, oxygen tension, or type of complex medium. N-terminal amino acid sequences of these proteins obtained by Edman degradation were compared with sequences from the University of Oklahoma A. actinomycetemcomitans genome database. Two contiguous open reading frames (ORFs) encoding proteins having sequence homology with these proteins were identified. The 43-kDa protein (RcpA [rough colony protein A]) was similar to precursor protein D of the general secretion pathway of gram-negative bacilli, while the 20-kDa protein (RcpB [rough colony protein B]) appeared to be unique. The genes encoding these proteins have been cloned from A. actinomycetemcomitans 283 and sequenced. A BLASTX (gapped BLAST) search of the surrounding ORFs revealed homology with other fimbria-related proteins. These data suggest that the genes encoding the 43-kDa (rcpA) and 20-kDa (rcpB) proteins may be functionally related to each other and to genes that may encode fimbria-associated proteins. (+info)A novel NDP-6-deoxyhexosyl-4-ulose reductase in the pathway for the synthesis of thymidine diphosphate-D-fucose. (4/397)
The serotype-specific polysaccharide antigen of Actinobacillus actinomycetemcomitans Y4 (serotype b) consists of D-fucose and L-rhamnose. Thymidine diphosphate (dTDP)-D-fucose is the activated nucleotide sugar form of D-fucose, which has been identified as a constituent of structural polysaccharides in only a few bacteria. In this paper, we show that three dTDP-D-fucose synthetic enzymes are encoded by genes in the gene cluster responsible for the synthesis of serotype b-specific polysaccharide in A. actinomycetemcomitans. The first and second steps of the dTDP-D-fucose synthetic pathway are catalyzed by D-glucose-1-phosphate thymidylyltransferase and dTDP-D-glucose 4,6-dehydratase, which are encoded by rmlA and rmlB in the gene cluster, respectively. These two reactions are common to the well studied dTDP-L-rhamnose synthetic pathway. However, the enzyme catalyzing the last step of the dTDP-D-fucose synthetic pathway has never been reported. We identified the fcd gene encoding a dTDP-4-keto-6-deoxy-D-glucose reductase. After purifying the three enzymes, their enzymatic activities were analyzed by reversed-phase high performance liquid chromatography. In addition, nuclear magnetic resonance analysis and gas-liquid chromatography analysis proved that the fcd gene product converts dTDP-4-keto-6-deoxy-D-glucose to dTDP-D-fucose. Moreover, kinetic analysis of the enzyme indicated that the Km values for dTDP-4-keto-6-deoxy-D-glucose and NADPH are 97.3 and 28.7 microM, respectively, and that the enzyme follows the sequential mechanism. This paper is the first report on the dTDP-D-fucose synthetic pathway and dTDP-4-keto-6-deoxy-D-glucose reductase. (+info)Improved multiplex PCR using conserved and species-specific 16S rRNA gene primers for simultaneous detection of Actinobacillus actinomycetemcomitans, Bacteroides forsythus, and Porphyromonas gingivalis. (5/397)
Among putative periodontal pathogens, Actinobacillus actinomycetemcomitans, Bacteroides forsythus, and Porphyromonas gingivalis are most convincingly implicated as etiological agents in periodontitis. Therefore, techniques for detection of those three species would be of value. We previously published a description of a multiplex PCR that detects A. actinomycetemcomitans and P. gingivalis. The present paper presents an improvement on that technique, which now allows more sensitive detection of all three periodontal pathogens. Sensitivity was determined by testing serial dilutions of A. actinomycetemcomitans, B. forsythus, and P. gingivalis cells. Primer specificity was tested against (i) all gene sequences from the GenBank-EMBL database, (ii) six A. actinomycetemcomitans, one B. forsythus, and four P. gingivalis strains, (iii) eight different species of oral bacteria, and (iv) supra- and subgingival plaque samples from 20 healthy subjects and subgingival plaque samples from 10 patients with periodontitis. The multiplex PCR had a detection limit of 10 A. actinomycetemcomitans, 10 P. gingivalis, and 100 B. forsythus cells. Specificity was confirmed by the fact that (i) none of our forward primers were homologous to the 16S rRNA genes of other oral species, (ii) amplicons of predicted size were detected for all A. actinomycetemcomitans, B. forsythus, and P. gingivalis strains tested, and (iii) no amplicons were detected for the eight other bacterial species. A. actinomycetemcomitans, B. forsythus, and P. gingivalis were detected in 6 of 20, 1 of 20, and 11 of 20 of supragingival plaque samples, respectively, and 4 of 20, 7 of 20, and 13 of 20 of subgingival plaque samples, respectively, from periodontally healthy subjects. Among patients with periodontitis, the organisms were detected in 7 of 10, 10 of 10, and 7 of 10 samples, respectively. The simultaneous detection of three periodontal pathogens is an advantage of this technique over conventional PCR assays. (+info)Identification of genes coding for exported proteins of Actinobacillus actinomycetemcomitans. (6/397)
Random fusions of genomic DNA fragments to a partial gene encoding a signal sequence-deficient bacterial alkaline phosphatase were utilized to screen for exported proteins of Actinobacillus actinomycetemcomitans in Escherichia coli. Twenty-four PhoA(+) clones were isolated and sequenced. Membrane localization signals in the form of signal sequences were deduced from most of these sequences. Several of the deduced amino acid sequences were found to be homologous to known exported or membrane-associated proteins. The complete genes corresponding to two of these sequences were isolated from an A. actinomycetemcomitans lambda phage library. One gene was found to be homologous to the outer membrane lipoprotein LolB. The second gene product had homology with a Haemophilus influenzae protein and was localized to the inner membrane of A. actinomycetemcomitans. (+info)Microtubules are associated with intracellular movement and spread of the periodontopathogen Actinobacillus actinomycetemcomitans. (7/397)
Actinobacillus actinomycetemcomitans SUNY 465, the invasion prototype strain, enters epithelial cells by an actin-dependent mechanism, escapes from the host cell vacuole, and spreads intracellularly and to adjacent epithelial cells via intercellular protrusions. Internalized organisms also egress from host cells into the assay medium via protrusions that are associated with just a single epithelial cell. Here we demonstrate that agents which inhibit microtubule polymerization (e.g., colchicine) and those which stabilize polymerized microtubules (e.g., taxol) both increase markedly the number of intracellular A. actinomycetemcomitans organisms. Furthermore, both colchicine and taxol prevented the egression of A. actinomycetemcomitans from host cells into the assay medium. Immunofluorescence microscopy revealed that protrusions that mediate the bacterial spread contain microtubules. A. actinomycetemcomitans SUNY 465 and 652, strains that are both invasive and egressive, interacted specifically with the plus ends (growing ends) of the filaments of microtubule asters in a KB cell extract. By contrast, neither A. actinomycetemcomitans 523, a strain that is invasive but not egressive, nor Haemophilus aphrophilus, a noninvasive oral bacterium with characteristics similar to those of A. actinomycetemcomitans, bound to microtubules. Together these data suggest that microtubules function in the spread and movement of A. actinomycetemcomitans and provide the first evidence that host cell dispersion of an invasive bacterium may involve the usurption of host cell microtubules. (+info)Direct selection of IS903 transposon insertions by use of a broad-host-range vector: isolation of catalase-deficient mutants of Actinobacillus actinomycetemcomitans. (8/397)
Transposon mutagenesis in bacteria generally requires efficient delivery of a transposon suicide vector to allow the selection of relatively infrequent transposition events. We have developed an IS903-based transposon mutagenesis system for diverse gram-negative bacteria that is not limited by transfer efficiency. The transposon, IS903phikan, carries a cryptic kan gene, which can be expressed only after successful transposition. This allows the stable introduction of the transposon delivery vector into the host. Generation of insertion mutants is then limited only by the frequency of transposition. IS903phikan was placed on an IncQ plasmid vector with the transposase gene located outside the transposon and expressed from isopropyl-beta-D-thiogalactopyranoside (IPTG)-inducible promoters. After transposase induction, IS903phikan insertion mutants were readily selected in Escherichia coli by their resistance to kanamycin. We used IS903phikan to isolate three catalase-deficient mutants of the periodontal pathogen Actinobacillus actinomycetemcomitans from a library of random insertions. The mutants display increased sensitivity to hydrogen peroxide, and all have IS903phikan insertions within an open reading frame whose predicted product is closely related to other bacterial catalases. Nucleotide sequence analysis of the catalase gene (designated katA) and flanking intergenic regions also revealed several occurrences of an 11-bp sequence that is closely related to the core DNA uptake signal sequence for natural transformation of Haemophilus influenzae. Our results demonstrate the utility of the IS903phikan mutagenesis system for the study of A. actinomycetemcomitans. Because IS903phikan is carried on a mobilizable, broad-host-range IncQ plasmid, this system is potentially useful in a variety of bacterial species. (+info)
Natural Transformation and DNA Uptake Signal Sequences in Actinobacillus actinomycetemcomitans | Journal of Bacteriology
Serum immunoglobulin G subclass concentrations in periodontally healthy and diseased individuals. | Infection and Immunity
Molecular pathogenicity of the oral opportunistic pathogen Actinobacillus actinomycetemcomitans
Caspase 1 involvement in human monocyte lysis induced by Actinobacillus actinomycetemcomitans leukotoxin
aggregatibacter actinomycetemcomitans periodontal disease
Aggregatibacter actinomycetemcomitans (Klinger 1912) Nørskov-Lauritsen
Aggregatibacter actinomycetemcomitans (Klinger 1912) Nørskov-Lauritsen
Structures of the antigenic O-polysaccharides of lipopolysaccharides produced by Actinobacillus actinomycetemcomitans serotypes...
Targeted delivery of a photosensitizer to Aggregatibacter actinomycetemcomitans biofilm - Zurich Open Repository and Archive
Cytotoxic mechanisms of Aggregatibacter actinomycetemcomitans leukotoxin - Angela Brown
ANTIMICROBIAL AND ANTIBIOFILM ACTIVITY OF CATHELICIDINS - Patent application
Infection by Porphyromonas gingivalis and Actinobacillus actinomycetemcomitans, and antibody responses at different ages in...
Cell surface-associated enolase in Actinobacillus actinomycetemcomitans<...
Aggregatibacter actinomycetemcomitans H-NS promotes biofilm formation and alters protein dynamics of other species within a...
The Actinobacillus actinomycetemcomitans Ribose Binding Protein RbsB Interacts with Cognate and Heterologous Autoinducer 2...
Cytolethal distending toxin in isolates of Aggregatibacter actinomycetemcomitans from Ghanaian adolescents and association with...
Aggregatibacter actinomycetemcomitans GroEL Protein Promotes Conversion of Human CD4 T Cells into IFNγ IL10 Producing Tbet Th1...
UniProt/TrEMBL: C9R3L9 AGGAD
A. actinomycetemcomitans b Antibody (141AA1) - DSHB
KEGG GENOME: Aggregatibacter actinomycetemcomitans D11S-1
Tryptic Soy-Serum-Bacitracin-Vancomycin Agar - TSBV - Anaerobe Systems
Oral lactobacilli reduce cytotoxicity and cytokine release from peripheral blood mononuclear cells exposed to Aggregatibacter...
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Researchers Add to Evidence That Common Bacterial Cause of Gum Disease May Drive Rheumatoid Arthritis :: By :: Article ::...
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Investigation of the structure of lipid A from Actinobacillus actinomycetemcomitans strain Y 4 and human clinical isolate PO...
Oral Lactobacillus strains reduce cytotoxicity and cytokine release from peripheral blood mononuclear cells exposed to...
Microbiologics: 01175K Aggregatibacter actinomycetemcomitans (b) derived from ATCC® 29522™* KWIK-STIK
Bdellovibrio bacteriovorus attacks Aggregatibacter actinomycetemcomitans
Isolation and characterization of the dnaKJ operon from Actinobacillus actinomycetemcomitans - Fingerprint
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497e) Design of a Cholesterol-Binding Peptide to Inhibit Bacterial Toxin Activity | AIChE
Bacterial heat shock protein GroEL (Hsp64) exerts immunoregulatory effects on T cells by utilizing apoptosis
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Short-Term Effects Of Systemic Antibiotics During Periodontal Healing
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Population-Based Study of Salivary Carriage of Periodontal Pathogens in Adults | Journal of Clinical Microbiology
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Differentiation of oral bacteria in in vitro cultures and human saliva by secondary electrospray ionization - mass spectrometry...
THE EFFECT OF CURCUMA XANTHORRHIZA ETHANOL EXTRACT ON THE VIABILITY OF STREPTOCOCCUS MUTANS AND AGGREGATIBACTER...
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Index of oral health and dental articles
Aggregatibacter actinomycetemcomitans • Aim toothpaste • Akers' clasp • Alberta Dental Association and College • Alfred Fones ...
Capnophile
found in the mouth (e.g. Aggregatibacter actinomycetemcomitans). These are a cause of aggressive juvenile periodontitis. ... Bhattacharjee, MK; Childs (June 2011). "Sensitivity of the periodontal pathogen Aggregatibacter actinomycetemcomitans at mildly ... Other capnophilic pathogens occur in the gram-negative Aggregatibacter spp. ...
Epoxygenase
Aggregatibacter actinomycetemcomitans and E. coli. That is, they are toxic to leukocytes as well as many other cell types and ...
Dental plaque
Aggregatibacter actinomycetemcomitans Prevotella intermedia Eubacterium spp. Treponema spp. Porphyromonas gingivalis ...
List of long species names
Aggregatibacter actinomycetemcomitans (Klinger, 1912) Nørskov-Lauritsen and Kilian, 2006 - family Pasteurellaceae. A Gram- ... nov., Aggregatibacter aphrophilus comb. nov. and Aggregatibacter segnis comb. nov., and emended description of Aggregatibacter ... Henderson B, Ward JM, Ready D (October 2010). "Aggregatibacter (Actinobacillus) actinomycetemcomitans: a triple A* ... Haemophilus paraphrophilus and Haemophilus segnis as Aggregatibacter actinomycetemcomitans gen. nov., comb. ...
Aggressive periodontitis
Various studies have associated Aggregatibacter actinomycetemcomitans, formerly known as Actinobacillus actinomycetemcomitans, ... As well as Aggregatibacter actinomycetemcomitans being associated with this, the synergism of the disease also accounts for ... High levels of Aggregatibacter (or Actinobacillus) actinomycetemcomitans and, in some populations, Porphyromonas gingivalis. ... This is due to the suppression of serum IgG2 and antibody against Aggregatibacter actinomycetemcomitans found in smokers. ...
Parish Sedghizadeh
The in vivo Th17 and Treg immune response to Aggregatibacter actinomycetemcomitans. Mol Oral Microbiol 2017;32:490-99. Junka A ... "The in vivo Th17 and Treg immune responses to Aggregatibacter actinomycetemcomitans". Sedghizadeh, Parish P.; Chen, Meng-Tse; ...
Coccobacillus
Aggregatibacter actinomycetemcomitans is a Gram-negative coccobacillus prevalent in subgingival plaques. Acinetobacter strains ...
Actinomyces
Aggregatibacter actinomycetemcomitans has been identified as being of note in periodontal disease. The genus is typically the ...
Bacterial cellular morphologies
Aggregatibacter actinomycetemcomitans is a gram negative coccobacillus which is prevalent in subgingival plaques. Acinetobacter ...
Actinobacillus
Haemophilus paraphrophilus and Haemophilus segnis as Aggregatibacter actinomycetemcomitans gen. nov., comb. nov., ... Aggregatibacter aphrophilus comb. nov. and Aggregatibacter segnis comb. nov., and emended description of Aggregatibacter ... A. actinomycetemcomitans occurs in the human oral microflora, and together with anaerobic or capnophilic organisms (HACEK group ... An analysis of A. actinomycetemcomitans indicated it was monophyletic with Haemophilus aphrophilus and H. segnis, and it was ...
Periodontal disease
Research in 2004 indicated three gram negative anaerobic species: Aggregatibacter actinomycetemcomitans, Porphyromonas ...
Jørgen Slots
Slots is responsible for discovering the role of Aggregatibacter actinomycetemcomitans (previously Actinobacillus ... "Comparison of Two Selective Media for Actinobacillus actinomycetemcomitans." J Clin Microbiol 1986;24:636-638. Fryman A, ... actinomycetemcomitans) in aggressive periodontitis, previously known as juvenile periodontitis. In 1982, Slots developed ...
Dispersin B
... is produced by Aggregatibacter actinomycetemcomitans, a Gram-negative oral bacterium, when it needs to detach and ... Aggregatibacter actinomycetemcomitans. The bacteria secrete Dispersin B to release adherent cells from a mature biofilm colony ... A. actinomycetemcomitans forms asymmetric biofilm lobed colonies that release single cells or small clusters of bacterial cells ... Kaplan JB, Ragunath C, Ramasubbu N, Fine DH (August 2003). "Detachment of Actinobacillus actinomycetemcomitans biofilm cells by ...
Tryptic soy-serum-bacitracin-vancomycin
... a type of agar plate medium used in microbiological testing to select for Aggregatibacter actinomycetemcomitans (A.a.). It was ... "Comparison of Two Selective Media for Actinobacillus actinomycetemcomitans." J Clin Microbiol 1986;24:636-638. Slots, J. " ... "Selective medium for isolation of Actinobacillus actinomycetemcomitans." J Clin Microbiol 1982;15:606-609.. ...
HACEK organisms
Haemophilus haemolyticus Haemophilus parahaemolyticus Aggregatibacter Aggregatibacter actinomycetemcomitans (previously ... Aggregatibacter segnis Aggregatibacter aphrophilus (previously Haemophilus aphrophilus) Aggregatibacter paraphrophilus ( ... However, taxonomic rearrangements have changed the A to Aggregatibacter species and the H to Haemophilus species to reflect the ... HACEK is an abbreviation of the initials of the genera of this group of bacteria: Haemophilus, Aggregatibacter (previously ...
List of bacterial vaginosis microbiota
Actinobacteria spp Anaerococcus spp Actinomyces naeslundii Aggregatibacter actinomycetemcomitans Atopobium vaginae Bacteroides ...
Maresin
Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans; the latter functional defects were improved by treating the ...
Cytolethal distending toxin
Medically important CDT producers include: Haemophilus ducreyi (chancroids) Aggregatibacter actinomycetemcomitans ( ...
DTDP-6-deoxy-L-talose 4-dehydrogenase (NAD+)
H+ The enzyme from bacterium Aggregatibacter actinomycetemcomitans participates in the biosynthesis of the serotype c-specific ... diphosphate-6-deoxy-L-lyxo-4-hexulose reductase synthesizing dTDP-6-deoxy-L-talose from Actinobacillus actinomycetemcomitans". ...
Periodontal pathogen
Aggregatibacter actinomycetemcomitans Porphyromonas gingivalis Tannerella forsythia (formerly Bacteroides forsythus) Treponema ...
Aggregatibacter
Haemophilus paraphrophilus and Haemophilus segnis as Aggregatibacter actinomycetemcomitans gen. Nov., comb. Nov., ... Aggregatibacter aphrophilus comb. Nov. And Aggregatibacter segnis comb. Nov., and emended description of Aggregatibacter ... Aggregatibacter is a genus in the phylum Proteobacteria (Bacteria), which contains three species, namely: A. ... actinomycetemcomitans (Klinger 1912) Nørskov-Lauritsen and Kilian 2006, (type species of the genus); (from Greek noun aktis, ...
Aggregatibacter actinomycetemcomitans
... (previously Actinobacillus actinomycetemcomitans) is a Gram-negative, facultative ... nov., Aggregatibacter aphrophilus comb. nov. and Aggregatibacter segnis comb. nov., and emended description of Aggregatibacter ... Type strain of Aggregatibacter actinomycetemcomitans at BacDive - the Bacterial Diversity Metadatabase. ... Haubek D (September 2010). "The highly leukotoxic JP2 clone of Aggregatibacter actinomycetemcomitans: evolutionary aspects, ...
Aggregatibacter iron-regulated sRNA
JA01 is conserved only among A. actinomycetemcomitans. JA02 is present in both A. actinomycetemcomitans and P. multocida. JA 03 ... sequence were identified by bioinformatics analysis in Aggregatibacter actinomycetemcomitans HK1651 called JA01-JA04. The ... "Novel iron-regulated and Fur-regulated small regulatory RNAs in Aggregatibacter actinomycetemcomitans". Molecular Oral ...
Urinary tract infection
Aggregatibacter actinomycetemcomitans. *HACEK. Legionellales. *Legionella pneumophila/Legionella longbeachae *Legionnaires' ...
Gonorrhea
Aggregatibacter actinomycetemcomitans. *HACEK. Legionellales. *Legionella pneumophila/Legionella longbeachae *Legionnaires' ...
Bacillary dysentery
Aggregatibacter actinomycetemcomitans. *HACEK. Legionellales. *Legionella pneumophila/Legionella longbeachae *Legionnaires' ...
Traveler's diarrhea
Aggregatibacter actinomycetemcomitans. *HACEK. Legionellales. *Legionella pneumophila/Legionella longbeachae *Legionnaires' ...
Meningococcal disease
Aggregatibacter actinomycetemcomitans. *HACEK. Legionellales. *Legionella pneumophila/Legionella longbeachae *Legionnaires' ...
Cytolethal distending Toxin
Medizinisch bedeutsame Cdt-produzierende Bakterien sind Haemophilus ducreyi, Aggregatibacter actinomycetemcomitans, Escherichia ...
ടൈഫോയ്ഡ് - വിക്കിപീഡിയ
Aggregatibacter actinomycetemcomitans (HACEK). Legionellales. Legionella pneumophila/Legionella longbeachae (Legionellosis) · ...
ಜಠರ/ಜಠರೀಯ ಹುಣ್ಣು/ವ್ರಣ - ವಿಕಿಪೀಡಿಯ
Aggregatibacter actinomycetemcomitans. *HACEK. Legionellales. *Legionella pneumophila/Legionella longbeachae *Legionnaires' ...
Chromobacteriosis infection
Aggregatibacter actinomycetemcomitans. *HACEK. Legionellales. *Legionella pneumophila/Legionella longbeachae *Legionnaires' ...
Bubonic plague
Aggregatibacter actinomycetemcomitans. *HACEK. Legionellales. *Legionella pneumophila/Legionella longbeachae *Legionnaires' ...
List of infectious diseases
Aggregatibacter actinomycetemcomitans. *HACEK. Legionellales. *Legionella pneumophila/Legionella longbeachae *Legionnaires' ...
কলেরা - উইকিপিডিয়া
Aggregatibacter actinomycetemcomitans (HACEK). Legionellales. Legionella pneumophila/Legionella longbeachae (Legionellosis) · ...
List of parasites of humans
Aggregatibacter actinomycetemcomitans. *HACEK. Legionellales. *Legionella pneumophila/Legionella longbeachae *Legionnaires' ...
Klebsiella aerogenes
Aggregatibacter actinomycetemcomitans. *HACEK. Legionellales. *Legionella pneumophila/Legionella longbeachae *Legionnaires' ...
Typhoid fever
Aggregatibacter actinomycetemcomitans. *HACEK. Legionellales. *Legionella pneumophila/Legionella longbeachae *Legionnaires' ...
Category:Dentistry
Aggregatibacter actinomycetemcomitans. *All-on-4. *Ameloblastic carcinoma. *Amosan. *Ante's law. *Apex location ...
Peptic ulcer disease
Aggregatibacter actinomycetemcomitans. *HACEK. Legionellales. *Legionella pneumophila/Legionella longbeachae *Legionnaires' ...
Neisseria meningitidis
Aggregatibacter actinomycetemcomitans. *HACEK. Legionellales. *Legionella pneumophila/Legionella longbeachae *Legionnaires' ...
Aggregatibacter actinomycetemcomitans - Wikipedia
Aggregatibacter actinomycetemcomitans (previously Actinobacillus actinomycetemcomitans) is a Gram-negative, facultative ... nov., Aggregatibacter aphrophilus comb. nov. and Aggregatibacter segnis comb. nov., and emended description of Aggregatibacter ... Type strain of Aggregatibacter actinomycetemcomitans at BacDive - the Bacterial Diversity Metadatabase. ... Haubek D (September 2010). "The highly leukotoxic JP2 clone of Aggregatibacter actinomycetemcomitans: evolutionary aspects, ...
Aggregatibacter actinomycetemcomitans (Klinger 1912) Nørskov-Lauritsen
Genomic DNA from Aggregatibacter actinomycetemcomitans strain HK1651 TypeStrain=False Application: ... Actinobacillus actinomycetemcomitans Strain Designations Genomic DNA from Aggregatibacter actinomycetemcomitans strain HK1651 [ ... nov., Aggregatibacter aphrophilus comb. nov. and Aggregatibacter segnis comb. nov., and emended description of Aggregatibacter ... Aggregatibacter actinomycetemcomitans (Klinger 1912) Nørskov-Lauritsen and Kilian 2006 ATCC® 700685D-5™ dried At least 5 µg in ...
KEGG GENOME: Aggregatibacter actinomycetemcomitans D11S-1
Toxins | Free Full-Text | Gangliosides Block Aggregatibacter Actinomycetemcomitans Leukotoxin (LtxA)-Mediated Hemolysis
A. actinomycetemcomitans produces leukotoxin (LtxA), an important virulence factor that targets white blood cells (WBCs) and ... actinomycetemcomitans. In this study, we further investigated how LtxA might recognize and lyse RBCs. We found that, in ... Aggregatibacter actinomycetemcomitans is an oral pathogen and etiologic agent of localized aggressive periodontitis. The ... Gangliosides Block Aggregatibacter Actinomycetemcomitans Leukotoxin (LtxA)-Mediated Hemolysis Michael S. Forman, Jason B. ...
Avaliação qualitativa, quantitativa e genotípica de Aggregatibacter actinomycetemcomitans...
Aggregatibacter actinomycetemcomitans e Fusobacterium nucleatum são microrganismos gram-negativos presentes nos processos ... Aggregatibacter actinomycetemcomitans. Fusobacterium nucleatum. Biofilme subgengival. Gengivite. Periodontite crônica. Resumo ... Aggregatibacter actinomycetemcomitans. Fusobacterium nucleatum. Chronic periodontitis. Gingivitis. Subgingival biofilm. Resumo ... Aggregatibacter actinomycetemcomitans e Fusobacterium nucleatum são microrganismos gram-negativos presentes nos processos ...
KEGG PATHWAY: Mismatch repair - Aggregatibacter actinomycetemcomitans D11S-1
Genome Summary of Aggregatibacter actinomycetemcomitans NUM4039
Genome Summary of Aggregatibacter actinomycetemcomitans IDH781
Aggregatibacter actinomycetemcomitans
... It has been a long-held supposition of many doctors and researchers that dental ... Aggregatibacter actinomycetemcomitans-induced hypercitrullination links periodontal infection to autoimmunity in rheumatoid ... Aggregatibacter actinomycetemcomitans (Aa), is one of a number of organisms contributing to periodontal gum disease that can ...
Oil Essential Mouthwashes Antibacterial Activity against Aggregatibacter actinomycetemcomitans: A Comparison between...
nov., Aggregatibacter aphrophilus comb. nov. and Aggregatibacter segnis comb. nov., and emended description of Aggregatibacter ... Aggregatibacter actinomycetemcomitans (Aa) is a gram-negative coccobacillus, facultative anaerobe, closely associated with the ... S. C. Kachlany, "Aggregatibacter actinomycetemcomitans leukotoxin: from threat to therapy," Journal of Dental Research, vol. 89 ... C. Y. Wang, H. C. Wang, J. M. Li et al., "Invasive infections of Aggregatibacter (Actinobacillus) Actinomycetemcomitans," ...
CF65 02195 - Oxaloacetate decarboxylase alpha subunit,putative - Aggregatibacter actinomycetemcomitans HK1651 - CF65 02195 gene...
Phosphorylcholine is located in Aggregatibacter actinomycetemcomitans fimbrial protein Flp 1
... Ihalin, Riikka Umeå University, ... Our aims were to determine the frequency of ChoP display among Aggregatibacter actinomycetemcomitans strains, to clarify which ... Aggregatibacter actinomycetemcomitans, Serotypes, Periodontitis, Phosphorylcholine, Fimbriae, Flp1, C-reactive protein, Serum ... It further seems that ChoP-positivity does not enhance but may reduce A. actinomycetemcomitans susceptibility to serum killing. ...
Adherence of Aggregatibacter actinomycetemcomitans via serotype-specific polysaccharide antigens in lipopolysaccharides
IntroductionGram-negative Aggregatibacter actinomycetemcomitans is recognized as an important periodontal pathogen. A striking ... IntroductionGram-negative Aggregatibacter actinomycetemcomitans is recognized as an important periodontal pathogen. A striking ... actinomycetemcomitans strain ATCC29523 (serotype a) was used to construct a deletion mutant of serotype-a specific ...
Pathogens | Free Full-Text | Distinct Signaling Pathways Between Human Macrophages and Primary Gingival Epithelial Cells by...
Small Things Considered: Aggregatibacter actinomycetemcomitans: A Unique Exotoxin-Producing Oral Bacterium
... the Gram-negative Aggregatibacter actinomycetemcomitans. For readers with an interest in taxonomy, this microbe was originally ... Aggregatibacter actinomycetemcomitans: A Unique Exotoxin-Producing Oral Bacterium by Pedro Valero-Guillén ... Zijnge V, Kieselbach T, & Oscarsson J (2012). Proteomics of protein secretion by Aggregatibacter actinomycetemcomitans. PloS ... The Toxins of A. actinomycetemcomitans. It has been known for quite some time that A. actinomycetemcomitans makes two toxins, ...
Antibiotic susceptibility of Aggregatibacter actinomycetemcomitans JP2 in a biofilm. | Harvard Catalyst Profiles | Harvard...
Comment on "Aggregatibacter actinomycetemcomitans-induced hypercitrullination links periodontal infection to autoimmunity in...
Occurrence of Aggregatibacter actinomycetemcomitans serotypes in subgingival plaque from United States subjects. Mol. Oral ... Comment on "Aggregatibacter actinomycetemcomitans-induced hypercitrullination links periodontal infection to autoimmunity in ... Comment on "Aggregatibacter actinomycetemcomitans-induced hypercitrullination links periodontal infection to autoimmunity in ... Comment on "Aggregatibacter actinomycetemcomitans-induced hypercitrullination links periodontal infection to autoimmunity in ...
Aggregatibacter actinomycetemcomitans-induced hypercitrullination links periodontal infection to autoimmunity in rheumatoid...
Among these, Aggregatibacter actinomycetemcomitans (Aa), but not other candidate pathogens, induced hypercitrullination in host ... Aggregatibacter actinomycetemcomitans generates citrullinated autoantigens involved in rheumatoid arthritis through its pore- ... Aggregatibacter actinomycetemcomitans generates citrullinated autoantigens involved in rheumatoid arthritis through its pore- ... Aggregatibacter actinomycetemcomitans-induced hypercitrullination links periodontal infection to autoimmunity in rheumatoid ...
Frontiers | Internalization and Intoxication of Human Macrophages by the Active Subunit of the Aggregatibacter...
The Aggregatibacter actinomycetemcomitans cytolethal distending toxin (Cdt) is a heterotrimeric AB2 toxin capable of inducing ... The Aggregatibacter actinomycetemcomitans cytolethal distending toxin (Cdt) is a heterotrimeric AB2 toxin capable of inducing ... The Aggregatibacter actinomycetemcomitans cytolethal distending toxin (Cdt) is a heterotrimeric AB2 toxin capable of inducing ... The Aggregatibacter actinomycetemcomitans cytolethal distending toxin active subunit CdtB contains a cholesterol recognition ...
Targeted delivery of a photosensitizer to Aggregatibacter actinomycetemcomitans biofilm - Zurich Open Repository and Archive
Biofilm microcolonies of Aggregatibacter actinomycetemcomitans, a periodontal pathogen, were targeted with the multifunctional ... Biofilm microcolonies of Aggregatibacter actinomycetemcomitans, a periodontal pathogen, were targeted with the multifunctional ... Targeted delivery of a photosensitizer to Aggregatibacter actinomycetemcomitans biofilm. Antimicrobial Agents and Chemotherapy ... Streptavidin was used to couple biotinylated dodecamer to a biotinylated anti-A. actinomycetemcomitans antibody. This modular ...
Microbiologics: 01175K Aggregatibacter actinomycetemcomitans (b) derived from ATCC® 29522™* KWIK-STIK
DIGITAL.CSIC: Variability in the response of human dendritic cells stimulated with Porphyromonas gingivalis or Aggregatibacter...
... actinomycetemcomitans. Although both pathogens induced a T helper 1 pattern of cytokine expression, A. actinomycetemcomitans- ... Results: Both P. gingivalis and A. actinomycetemcomitans led to dendritic cell maturation, but the expression of CD80 was ... While 106 bacteria/mL of P. gingivalis or 104 bacteria/mL of A. actinomycetemcomitans induced expression of interleukin-12p40, ... Conclusion: These results demonstrate that A. actinomycetemcomitans is a more potent immunogen than P. gingivalis because, at ...
Aggregatibacter actinomycetemcomitans H-NS promotes biofilm formation and alters protein dynamics of other species within a...
Aggregatibacter actinomycetemcomitans H-NS promotes biofilm formation and alters protein dynamics of other species within a ... Aggregatibacter actinomycetemcomitans is a Gram-negative organism, strongly associated with aggressive forms of periodontitis. ... Aggregatibacter actinomycetemcomitans, H-NS, oral biofilm, oral microbiology, aggressive periodontitis, proteomics Nationell ... To evaluate the role of H-NS in A. actinomycetemcomitans, hns mutant derivatives of serotype a strain D7S were generated. ...
The Extracellular Domain of the β2 Integrin β Subunit (CD18) Is Sufficient for Escherichia coli Hemolysin and Aggregatibacter...
Human CD18 is the functional receptor for Aggregatibacter actinomycetemcomitans leukotoxin. Infect Immun 75:4851-4856. doi: ... Aggregatibacter actinomycetemcomitans leukotoxin requires beta-sheets 1 and 2 of the human CD11a beta-propeller for ... Aggregatibacter actinomycetemcomitans leukotoxin causes activation of lymphocyte function-associated antigen 1. Cell Microbiol ... HlyA is the prototype of the repeats-in-toxin (RTX) family, which includes LtxA from Aggregatibacter actinomycetemcomitans, a ...
Utilization of Variant and Fusion Proteins To Functionally Map the Aggregatibacter actinomycetemcomitans Trimeric...
Utilization of Variant and Fusion Proteins To Functionally Map the Aggregatibacter actinomycetemcomitans Trimeric ... Utilization of Variant and Fusion Proteins To Functionally Map the Aggregatibacter actinomycetemcomitans Trimeric ... Utilization of Variant and Fusion Proteins To Functionally Map the Aggregatibacter actinomycetemcomitans Trimeric ... Utilization of Variant and Fusion Proteins To Functionally Map the Aggregatibacter actinomycetemcomitans Trimeric ...
Aggregatibacter actinomycetemcomitans Outer Membrane Vesicles Are Internalized in Human Host Cells and Trigger NOD1- and NOD2...
Aggregatibacter actinomycetemcomitans Outer Membrane Vesicles Are Internalized in Human Host Cells and Trigger NOD1- and NOD2- ... Aggregatibacter actinomycetemcomitans is an oral and systemic human pathogen that is associated with aggressive forms of ... Aggregatibacter actinomycetemcomitans Outer Membrane Vesicles Are Internalized in Human Host Cells and Trigger NOD1- and NOD2- ... Aggregatibacter actinomycetemcomitans Outer Membrane Vesicles Are Internalized in Human Host Cells and Trigger NOD1- and NOD2- ...
Lymphoid susceptibility to the Aggregatibacter actinomycetemcomitans cytolethal distending toxin is dependent upon baseline...
Docosahexaenoic acid attenuates cell death and interleukin-1beta secretion in THP-1 cells responded to Aggregatibacter...
Docosahexaenoic acid attenuates cell death and interleukin-1beta secretion in THP-1 cells responded to Aggregatibacter ... Aggregatibacter actinomycetemcomitans, Macrophage, Inflammasome, Interleukin-1β, Cell death. Introduction. Aggregatibacter ... Aggregatibacter actinomycetemcomitans infection enhances apoptosis in vivo through a caspase-3-dependent mechanism in ... Aggregatibacter actinomycetemcomitans, a potent immunoregulator of the periodontal host defense system and alveolar bone ...
Microbiology Society Journals | Inner-membrane protein MorC is involved in fimbriae production and biofilm formation in...
These results suggest that MorC influences fimbrial secretion and microcolony formation in A. actinomycetemcomitans. ... secretion and assembly on the surface of the periodontal pathogen Aggregatibacter actinomycetemcomitans are essential for ... Tang G. , Mintz K. P. (2010). Glycosylation of the collagen adhesin EmaA of Aggregatibacter actinomycetemcomitans is dependent ... Smith K. P. (2015). A conserved inner membrane protein of Aggregatibacter actinomycetemcomitans is integral for membrane ...
ActinobacillusPathogenPeriodontitisPorphyromonasSerotypeBacteriaStrainsHaemophilusAphrophilusVirulence factorsLeukotoxinPasteurellaceaeBiofilm formationPutativeATCCBacteriumPathogensPathogenicityFusobacteriumSpeciesSusceptibilityAdhesinLeukotoxicCytokineMacrophagesSegnisBiofilmsCytolethalInfectionLtxAAssociated with periodontal diseaseSubgingivalClinicalToxinsStrainProteinGram-negative0.05SerotypesVesiclesIntermediaOral cavityAlveolar boneGenesSecretionInfections such as endocarditisNucleatum
Actinobacillus19
- Aggregatibacter actinomycetemcomitans (previously Actinobacillus actinomycetemcomitans) is a Gram-negative, facultative anaerobe, nonmotile bacterium that is often found in association with localized aggressive periodontitis, a severe infection of the periodontium. (wikipedia.org)
- It was reclassified as Actinobacillus actinomycetemcomitans by Topley & Wilson (1929) and as Haemophilus actinomycetemcomitans by Potts et al. (wikipedia.org)
- Aggregatibacter (Actinobacillus) actinomycetemcomitans: a triple A* periodontopathogen? (wikipedia.org)
- Reclassification of Actinobacillus actinomycetemcomitans, Haemophilus aphrophilus, Haemophilus paraphrophilus and Haemophilus segnis as Aggregatibacter actinomycetemcomitans gen. nov., comb. (wikipedia.org)
- Nørskov-Lauritsen N, Kilian M. Reclassification of Actinobacillus actinomycetemcomitans, Haemophilus aphrophilus, Haemophilus paraphrophilus and Haemophilus segnis as Aggregatibacter actinomycetemcomitans gen. nov., comb. (atcc.org)
- Haubek D, Poulsen K, Kilian M. Microevolution and patterns of dissemination of the JP2 clone of Aggregatibacter (Actinobacillus) actinomycetemcomitans. (atcc.org)
- For readers with an interest in taxonomy, this microbe was originally named Actinobacillus actinomycetemcomitans and later reclassified and renamed (you known taxonomists. (asmblog.org)
- 2. Henderson B., Ward J.M., Ready D. Aggregatibacter (Actinobacillus) actinomycetemcomitans: a triple A* periodontopathogen? (cmac-journal.ru)
- 6. Fine D.H., Kaplan J.B., Kachlany S.C., Schreiner H.C. How we got attached to Actinobacillus actinomycetemcomitans: a model for infectious diseases. (cmac-journal.ru)
- 7. Belibasakis G.N., Mattsson A., Wang Y., Chen C., Johansson A. Cell cycle arrest of human gingival fibroblasts and periodontal ligament cells by Actinobacillus actinomycetemcomitans: involvement of the cytolethal distending toxin. (cmac-journal.ru)
- 10. Taichman N.S., Simpson D.L., Sakurada S., Cranfield M., DiRienzo J., Slots J. Comparative studies on the biology of Actinobacillus actinomycetemcomitans leukotoxin in primates. (cmac-journal.ru)
- Henderson B, Nair SP, Ward JM, Wilson M. Molecular pathogenicity of the oral opportunistic pathogen Actinobacillus actinomycetemcomitans. (innovareacademics.in)
- Actinobacillus actinomycetemcomitans produces a pore-forming leukotoxin that lyses human polymorphonuclear leukocytes and monocytes. (nih.gov)
- The main causative organism of this disease is Actinobacillus actinomycetemcomitans. (nih.gov)
- Various studies have associated Aggregatibacter actinomycetemcomitans , formerly known as Actinobacillus actinomycetemcomitans , with aggressive periodontitis. (wikipedia.org)
- CHARACTERISTICS: Actinobacillus and Aggregatibacter spp. (msdsonline.com)
- HOST RANGE: Actinobacillus and Aggregatibacter spp. (msdsonline.com)
- Actinobacillus or Aggregatibacter spp. (msdsonline.com)
- DRUG SUSCEPTIBILITY/RESISTANCE: Actinobacillus or Aggregatibacter strains are generally susceptible to a range of antibiotics, including cephalosporins, cefotaxime, cefazolin, doxycycline and aminoglycosides (1, 3). (msdsonline.com)
Pathogen18
- Aggregatibacter actinomycetemcomitans is an oral pathogen and etiologic agent of localized aggressive periodontitis. (mdpi.com)
- Multi-center research conducted at numerous, prestigious medical institutions in the United States and Denmark, conclude that an oral pathogen, Aggregatibacter actinomycetemcomitans (Aa), is one of a number of organisms contributing to periodontal gum disease that can trigger the production of auto-antibody citrullinated proteins in genetically susceptible (HLA-DRB1) rheumatoid arthritis (RA) individuals. (roadback.org)
- Introduction Gram-negative Aggregatibacter actinomycetemcomitans is recognized as an important periodontal pathogen. (ovid.com)
- now demonstrate that a particular periodontal pathogen called Aggregatibacter actinomycetemcomitans ( Aa ) induces changes in neutrophil function, including hypercitrullination of host proteins, an abnormality that is also observed in the joints of patients with rheumatoid arthritis. (sciencemag.org)
- Biofilm microcolonies of Aggregatibacter actinomycetemcomitans, a periodontal pathogen, were targeted with the multifunctional dodecamer. (uzh.ch)
- HlyA is the prototype of the repeats-in-toxin (RTX) family, which includes LtxA from Aggregatibacter actinomycetemcomitans , a periodontal pathogen. (asm.org)
- Aggregatibacter actinomycetemcomitans is an oral and systemic pathogen associated with aggressive forms of periodontitis and with endocarditis. (asm.org)
- This work reveals a role of A. actinomycetemcomitans OMVs as a trigger of innate immunity via carriage of NOD1- and NOD2-active pathogen-associated molecular patterns (PAMPs). (asm.org)
- Aggregatibacter actinomycetemcomitans is an oral and systemic human pathogen that is associated with aggressive forms of periodontitis and with endocarditis ( 16 - 18 ). (asm.org)
- Fimbrial subunit synthesis, secretion and assembly on the surface of the periodontal pathogen Aggregatibacter actinomycetemcomitans are essential for biofilm formation. (microbiologyresearch.org)
- For many years A. actinomycetemcomitans was not considered an independent pathogen. (981heritage.com)
- A. actinomycetemcomitans is a very important periodontal pathogen. (981heritage.com)
- Aggregatibacter actinomycetemcomitans is a Gram-negative pathogen that is the etiologic agent of localized aggressive periodontitis (LAP) and other systemic infections, including infective endocarditis. (grantome.com)
- The new insights gained from understanding how A. actinomycetemcomitans regulates surface protein expression on a basal level as well as during physiological niche adaptation will aid in the development of molecules to disrupt and/or diminish tissue colonization by this pathogen. (grantome.com)
- Aggregatibacter actinomycetemcomitans, a potent pathogen of periodontitis, typically grows as a rough and adherent colony on primary isolated cultures. (elsevier.com)
- One of the heat shock family protein Hsp expressing bacteria is the gram negative, periodontal pathogen Aggregatibacter actinomycetemcomitans Aa. (duhnnae.com)
- Aggregatibacter actinimycetemcomitans is an important pathogen related to aggressively progressive periodontal breakdown in adolescents and adults [4,5]. (crimsonpublishers.com)
- Aggregatibacter actinomycetemcomitans is a Gram-negative opportunistic pathogen and the proposed causative agent of localized aggressive periodontitis. (utexas.edu)
Periodontitis19
- In this study, a qualitative, quantitative and genotypic analysis of A. actinomycetemcomitans and F. nucleatum isolated from patients with gingivitis, chronic periodontitis and healthy subjects were determined. (usp.br)
- Aggregatibacter actinomycetemcomitans ( Aa ) is a gram-negative coccobacillus, facultative anaerobe, closely associated with the aetiology of severe periodontitis, but it is also implicated in different human systemic diseases, such as infective endocarditis and, rarely, in brain abscesses, osteomyelitis, or low birth weight [ 1 - 4 ]. (hindawi.com)
- Aggregatibacter actinomycetemcomitans is a Gram-negative organism, strongly associated with aggressive forms of periodontitis. (diva-portal.org)
- Åberg CH, Kelk P, Johansson A. Aggregatibacter actinomycetemcomitans: virulence of its leukotoxin and association with aggressive periodontitis. (981heritage.com)
- Keywords: aggregatibacter actinomycetemcomitans, aggressive periodontitis, bone resorption, infection, inflammation, IL-1b, leukotoxin Periodontitis is an infection-induced inflammatory disease that causes loss of the tooth supporting tissues. (981heritage.com)
- Aggregatibacter actinomycetemcomitans (A. actinomycetemcomitans) is a Gram-negative, facultative anaerobic bacillus that causes periodontal diseases such as localized aggressive periodontitis (LAP) and. (981heritage.com)
- It has also been suggested that there is an association between the leukotoxicity of A. actinomycetemcomitans and aggressive forms of periodontitis [ 12 ]. (biomedcentral.com)
- Aggregatibacter actinomycetemcomitans is considered to be a key periodontopathogen and has been associated with aggressive periodontitis (Tonetti and Mombelli, 1999). (dentisty.org)
- Periodontitis associated with A. actinomycetemcomitans is difficult to treat reliably by mechanical removal of the subgingival biofilm alone (Mombelli et al. (dentisty.org)
- 4. Haubek D. The highly leukotoxic JP2 clone of Aggregatibacter actinomycetemcomitans: evolutionary aspects, epidemiology and etiological role in aggressive periodontitis. (cmac-journal.ru)
- Genetic Profiling of Aggregatibacter actinomycetemcomitans Serotype B Isolated from Periodontitis Patients Living in Sweden. (nih.gov)
- The objective of this study was to determine whether the detection of Aggregatibacter actinomycetemcomitans (Aa) correlates with the clinical and immunoinflammatory profile of Localized Aggressive Periodontitis (LAP), as determined by by 16S rRNA gene-based microarray. (wellesley.edu)
- Kataria S, Chandrashekar K.T, Mishra R, Tripathi V, Galav A and Sthapak U. Effect of tetracycline HCL (periodontal plus AB) on Aggregatibacter actinomycetemcomitans levels in chronic periodontitis . (hoajonline.com)
- In each patient, periodontal pockets were treated with scaling and root planing alone (control site), or treated by scaling and root planing followed by placement of tetracycline fiber (test site), with the aim of evaluating Aggregatibacter actinomycetemcomitans in chronic periodontitis. (hoajonline.com)
- Antecedentes La investigación de la microflora subgingival en pacientes diabéticos tipo 2 con periodontitis ha presentado resultados contradictorios. (bvsalud.org)
- Among them, Porphyromonas gingivalis , Aggregatibacter actinomycetemcomitans, and Prevotella intermedia are strongly implicated in the etiology of chronic periodontitis. (jidonline.com)
- History em Aggregatibacter actinomycetemcomitans /em [1] can be a little Gram-negative pole implicated in intense types of periodontitis [2]. (complextraitgenomics.com)
- A. actinomycetemcomitans is typically associated with Periodontitis, an inflammatory disease of the tissues surrounding and supporting the teeth, which left untreated results in tooth loss. (uvm.edu)
- Conversely, the JP2 clone of A. actinomycetemcomitans has enhanced virulence and causes significantly higher prevalence of aggressive periodontitis in adolescents whose descent can be traced back to the Mediterranean and Western parts of Africa(6). (msdsonline.com)
Porphyromonas15
- In this investigation, we analyzed the response of human dendritic cells to stimulation with different concentrations of Porphyromonas gingivalis or Aggregatibacter actinomycetemcomitans. (csic.es)
- The present cross-sectional study aimed to verify the prevalence of three periodontal pathogens, Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Prevotella intermedia, on different groups, with and without teeth. (bvsalud.org)
- Porphyromonas gingivalis, Prevotella intermedia, Prevotella nigrescens, Prevotella melaninogenica and Prevotella loeschii inhibited the leukotoxicity of A. actinomycetemcomitans cells as well as the activity of leukotoxin purified from the same strain. (nih.gov)
- Determinar la presencia de Porphyromonas gingivalis , Tannerella forshytia, Treponema denticola y Aggregatibacter actinomycetemcomitans , en el biofilm subgingival de pacientes diabéticos tipo 2 y relacionarlo con el grado de control metabólico. (bvsalud.org)
- En el grupo de pacientes estudiados, Treponema denticola y Tannerella forsythia fueron las bacterias más prevalentes (65.2 por ciento), seguida por Porphyromonas gingivalis (17.3 por ciento) y Aggregatibacter actinomycetemcomitans (13 por ciento). (bvsalud.org)
- Los pacientes con peor control glicémico tuvieron una mayor presencia de Treponema denticola , Tannerella forsythia , Porphyromonas gingivalis y Agreggatibacter actinomycetemcomitans y un aumento en el índice de sangrado al sondaje. (bvsalud.org)
- To determine the presence of Porphyromonas gingivalis , Tannerella forshytia, Treponema denticola and Aggregatibacter actinomycetemcomitans in subgingival biofilm of patients with diabetes type 2 and to relate it to the degree of metabolic control . (bvsalud.org)
- In the group of patients examined the most prevalent bacteria were, Treponema denticola and Tannerella forsythia (65.2 percent), followed by Porphyromonas gingivalis (17.3 percent) and Aggregatibacter actinomycetemcomitans (13 percent). (bvsalud.org)
- Patients with poor glycemic control had a greater presence of Treponema denticola , Tannerella forsythia , Porphyromonas gingivalis and Agreggatibacter actinomycetemcomitans and an increase in the rate of bleeding on probing. (bvsalud.org)
- The aim of this study was to evaluate the in vitro antimicrobial efficacy of Catharanthus roseus leaf extract against standard strains of periodontal pathogens, Porphyromonas gingivalis , Aggregatibacter actinomycetemcomitans , and Prevotella intermedia . (jidonline.com)
- Aggregatibacter actinomycetemcomitans , Enterococcus faecalis, and Porphyromonas gulae were not detected in any of the samples analyzed. (scielo.br)
- Aggregatibacter actinomycetemcomitans, Enterococcus faecalis e Porphyromonas gulae não foram detectados em nenhuma das amostras pesquisadas. (scielo.br)
- Greater numbers of both Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans were found in active, destructive periodontal lesions in comparison to non-active sites. (wikipedia.org)
- As well as Aggregatibacter actinomycetemcomitans being associated with this, the synergism of the disease also accounts for both Capnocytophaga spp and Porphyromonas gingivalis . (wikipedia.org)
- Treponema denticola, Porphyromonas ginigivalis, and Aggregatibacter actinomycetemcomitans are the main species involved in periodontal disease. (clinicaltrials.gov)
Serotype11
- Genome sequence of Aggregatibacter actinomycetemcomitans serotype c strain D11S-1. (genome.jp)
- Methods Non-fimbriated A. actinomycetemcomitans strain ATCC29523 (serotype a) was used to construct a deletion mutant of serotype-a specific polysaccharide antigen (SPA-a) in lipopolysaccharide (LPS). (ovid.com)
- To evaluate the role of H-NS in A. actinomycetemcomitans , hns mutant derivatives of serotype a strain D7S were generated. (diva-portal.org)
- Colocalization analysis revealed that internalized OMVs colocalized with the endoplasmic reticulum and carried antigens, detected using an antibody specific to whole A. actinomycetemcomitans serotype a cells. (asm.org)
- Differential Cell Lysis Among Periodontal Strains of JP2 and Non-JP2 Genotype of Aggregatibacter actinomycetemcomitans Serotype B Is Not Reflected in Dissimilar Expression and Production of Leukotoxin. (nih.gov)
- A bacteriophage specific for Aggregatibacter actinomycetemcomitans serotype b, able to kill the bacterium within a biofilm, was isolated. (unab.cl)
- The cagE gene sequence as a diagnostic marker to identify JP2 and non-JP2 highly leukotoxic Aggregatibacter actinomycetemcomitans serotype b strains. (scilifelab.se)
- Whereas cagE was absent in the other serotypes, our data support that this gene sequence is linked to a virulent and highly leukotoxic group of serotype b strains, including both JP2 and non-JP2 genotypes of A. actinomycetemcomitans. (scilifelab.se)
- For the assessment of antibody to A. actinomycetemcomitans, a mixed suspension of three strains (ATCC#43718, #29523 and #33384) was used (A. actinomycemtecomitans mix) as well as individual preparations from A. actinomycemtecomitans serotype a (ATCC strain #29523) and serotype b (ATCC strain #43718, Y4). (cdc.gov)
- Aggregatibacter actinomycetemcomitans serotype b str. (expasy.org)
- Aggregatibacter actinomycetemcomitans is commonly found in Asian populations and several studies showed a clear predominance of serotype c in Japanese, Chinese, Vietnamese, and Korean individuals (6). (msdsonline.com)
Bacteria4
- While 106 bacteria/mL of P. gingivalis or 104 bacteria/mL of A. actinomycetemcomitans induced expression of interleukin-12p40, the expression of other cytokines required 10 to 100-fold higher concentrations of bacteria. (csic.es)
- A. actinomycetemcomitans has many virulence factors that facilitate attachment and proliferation of these bacteria in the host. (981heritage.com)
- Certain proteolytic bacteria may coexist with A. actinomycetemcomitans in periodontal pockets. (nih.gov)
- We aimed therefore to examine whether oral bacteria can modify the leukotoxicity of A. actinomycetemcomitans. (nih.gov)
Strains12
- Our aims were to determine the frequency of ChoP display among Aggregatibacter actinomycetemcomitans strains, to clarify which surface structures bear ChoP, and whether ChoP-positivity relates to serum killing. (diva-portal.org)
- Some strains of A. actinomycetemcomitans , especially those directly subcultured from oral biofilms, produce rough, adherent colonies with cells containing abundant fimbriae appendages. (asmblog.org)
- Proteomics analysis of the strains grown in monocultures confirmed the role of H-NS as a repressor of gene expression in A. actinomycetemcomitans . (diva-portal.org)
- The supernatants and cell wall extracts (CWEs) of eight A. actinomycetemcomitans strains, representing different subtypes, and three Lactobacillus strains were used. (researchsquare.com)
- The PBMC cells from six blood donors were exposed to supernatants and CWEs of A. actinomycetemcomitans or Lactobacillus strains alone or combinations and untreated cells as control. (researchsquare.com)
- Results: Supernatants or CWEs from all bacterial strains showed cytotoxicity and IL-1β secretion and the subtypes of A. actinomycetemcomitans showed generally a significantly higher effect on PBMC´s than that of the Lactobacillus strains. (researchsquare.com)
- Two highly toxic A. actinomycetemcomitans strains (JP2 and JP2-like) induced a higher response than all other strains. (researchsquare.com)
- Two non-serotypable strains (NS1 and NS2) showed a weaker although significant effect than other A. actinomycetemcomitans or Lactobacillus strains tested. (researchsquare.com)
- Comprehensive antimicrobial susceptibility testing of a large collection of clinical strains of Aggregatibacter actinomycetemcomitans does not identify resistance to amoxicillin. (nih.gov)
- Today's study was made to investigate the conservation and presence of PAL among clinical em A. actinomycetemcomitans /em strains and whether live em A. actinomycetemcomitans /em cells launch PAL (AaPAL) in free-soluble type. (complextraitgenomics.com)
- Results The em pal /em gene was conserved and the protein expressed in clonally diverse em A. actinomycetemcomitans /em strains A total of 33 em A. actinomycetemcomitans /em strains were analyzed by PCR and immunoblotting. (complextraitgenomics.com)
- Open in a separate window Figure 1 PCR-RFLP of em pal /em and detection of its gene product, PAL, from clonally diverse em A. actinomycetemcomitans /em strains. (complextraitgenomics.com)
Haemophilus3
- Recent studies have shown a phylogenetic similarity of A. actinomycetemcomitans and Haemophilus aphrophilus, H. paraphrophilus, and H. segnis, suggesting the new genus Aggregatibacter for them. (wikipedia.org)
- 1985) 83 as Haemophilus actinomycetemcomitans. (981heritage.com)
- And Wilson ( 1929 ) and as Haemophilus 1997 ) 127,128 suggest that primary receptor for A. actinomycetemcomitans invasion epithelial. (981heritage.com)
Aphrophilus1
- Aggregatibacter aphrophilus comb. (wikipedia.org)
Virulence factors5
- Yet, oddly, these virulence factors are fairly rare among oral pathogens, with one exception, the Gram-negative Aggregatibacter actinomycetemcomitans . (asmblog.org)
- In periodontal tissue, A. actinomycetemcomitans induces host immune responses by producing exotoxicand endotoxic virulence factors [ 2 ]. (alliedacademies.org)
- A. actinomycetemcomitans expresses several virulence factors that enable it to colonize and invade oral tissues, avoid the host defense system, and cause tissue destruction [ 5 ]. (biomedcentral.com)
- The manner in which A. actinomycetemcomitans causes LAP is not known;however, it is known that it produces several putative virulence factors, including a leukotoxin (LtxA), a member of the repeats-in-toxin (RTX) family. (grantome.com)
- 2000) have categorised the virulence factors of Aggregatibacter actinomycetemcomitans as follows. (wikipedia.org)
Leukotoxin4
- A. actinomycetemcomitans produces leukotoxin (LtxA), an important virulence factor that targets white blood cells (WBCs) and plays a role in immune evasion during disease. (mdpi.com)
- The PACs also protected macrophages from the deleterious effect of leukotoxin Ltx-A and dose-dependently inhibited the secretion of pro-inflammatory cytokines (IL-1β, IL-6, CXCL8, TNF-α), matrix metalloproteinases (MMP-3, MMP-9), and sTREM-1 by A. actinomycetemcomitans -treated macrophages. (biomedcentral.com)
- 8. Kachlany S.C. Aggregatibacter actinomycetemcomitans leukotoxin: from threat to therapy. (cmac-journal.ru)
- The results imply a role of the periodontal microflora in modifying the virulence of A. actinomycetemcomitans by destroying its leukotoxin. (nih.gov)
Pasteurellaceae2
- aggregatibacter, rod-shaped bacterium that aggregates with others) was added to the family pasteurellaceae. (981heritage.com)
- A. actinomycetemcomitans относится к семейству Pasteurellaceae . (cmac-journal.ru)
Biofilm formation3
- Taken together, our data suggest that, apart from being a negative regulator of protein expression in A. actinomycetemcomitans , H-NS promotes biofilm formation and may be an important factor for survival of this species within a multispecies biofilm. (diva-portal.org)
- A microplate dilution assay was performed to determine the effect of highbush blueberry PACs on A. actinomycetemcomitans growth as well as biofilm formation stained with crystal violet. (biomedcentral.com)
- Highbush blueberry PACs reduced the growth of A. actinomycetemcomitans and prevented biofilm formation at sub-inhibitory concentrations. (biomedcentral.com)
Putative1
- The cagE gene encodes a ≈39 kDa putative exotoxin expressed by A. actinomycetemcomitans. (scilifelab.se)
ATCC1
- Material and Methods: Using different concentrations of P. gingivalis ATCC 33277 and A. actinomycetemcomitans ATCC 33384, we determined the expression of the maturation markers CD80 and CD86 from purified human dendritic cells by flow cytometry. (csic.es)
Bacterium4
- In this study, we investigated the effects of omega-3 fatty acids on inflammatory responses and cell death induced by the Gram-negative bacterium Aggregatibacter actinomycetemcomitans in macrophages. (alliedacademies.org)
- Aggregatibacter actinomycetemcomitans is a Gram-negative bacterium associated with periodontal disease and a variety of disseminated extra-oral infections. (grantome.com)
- Studies that have examined the prevalence and the distribution of A. actinomycetemcomitans (A.a.) serotypes and the relation between the different serotypes of the bacterium and periodontal status were reviewed. (crimsonpublishers.com)
- My research interests are concentrated on the membrane proteins and surface structures of the Gram-negative bacterium Aggregatibacter actinomycetemcomitans . (uvm.edu)
Pathogens2
- Although both pathogens induced a T helper 1 pattern of cytokine expression, A. actinomycetemcomitans-stimulated dendritic cells expressed interleukin-1β, interleukin-12, interferon-γ, tumor necrosis factor-α and tumor necrosis factor-β at lower bacterial concentrations than P. gingivalis. (csic.es)
- In conclusion, in this small subject group, none of the pathogens were associated with race and periodontal disease status and only A. actinomycetemcomitans had a significant association with CAL. (981heritage.com)
Pathogenicity1
- Virulence and Pathogenicity Properties of Aggregatibacter actinomycetemcomitans . (nih.gov)
Fusobacterium4
- Avaliação qualitativa, quantitativa e genotípica de Aggregatibacter actinomycetemcomitans e Fusobacterium nucleatum isolados de pacientes com diferentes condições clínicas bucais. (usp.br)
- Aggregatibacter actinomycetemcomitans e Fusobacterium nucleatum são microrganismos gram-negativos presentes nos processos inflamatórios e nas diferentes formas da doença periodontal. (usp.br)
- Qualitative, quantitative and genotypic evaluation of Aggregatibacter actinomycetemcomitans and Fusobacterium nucleatum isolated from patients with diferent oral clinical conditions. (usp.br)
- Aggregatibacter actinomycetemcomitans and Fusobacterium nucleatum are gram-negative microorganisms observed in inflammatory processes and different forms of periodontal disease. (usp.br)
Species3
- Interestingly, proteomics analysis of the multispecies biofilms indicated that the A. actinomycetemcomitans wild type and hns mutant imposed different regulatory effects on the pattern of protein expression in the other species, i.e., mainly Streptococcus spp. (diva-portal.org)
- This study aimed to compare the effect of Curcuma xanthrorrhiza ethanol extract to the viability of Streptococcus mutans and Aggregatibacter actinomycetemcomitans using single- and dual-species biofilm at different phases of formation. (innovareacademics.in)
- 0.05) was found between singlespecies A. actinomycetemcomitans and dual-species biofilm. (innovareacademics.in)
Susceptibility2
- It further seems that ChoP-positivity does not enhance but may reduce A. actinomycetemcomitans susceptibility to serum killing. (diva-portal.org)
- Antibiotic susceptibility of Aggregatibacter actinomycetemcomitans JP2 in a biofilm. (harvard.edu)
Adhesin2
Leukotoxic1
- Each strain was incubated with the highly toxic strain of A. actinomycetemcomitans HK 1519 and the leukotoxic activity of the suspension against human polymorphonuclear leukocytes was determined from the activity of the lactate dehydrogenase released upon lysis of the leukocytes. (nih.gov)
Cytokine3
- Oral lactobacilli reduce cytotoxicity and cytokine release from peripheral blood mononuclear cells exposed to Aggregatibacter actinomycetemcomitans subtypes in vitro. (researchsquare.com)
- Background: This study evaluated the effect of oral lactobacilli on the cytotoxicity and cytokine release from peripheral blood mononuclear cells (PBMC) when exposed to Aggregatibacter actinomycetemcomitans subtypes in vitro. (researchsquare.com)
- Pro-inflammatory cytokine and MMP secretion by A. actinomycetemcomitans -stimulated macrophages was quantified by ELISA. (biomedcentral.com)
Macrophages2
- Taken together, our data suggest that DHA attenuates the secretion of IL-1β and cell death induced by A. actinomycetemcomitans invasion of macrophages via suppression of inflammasome-associated factors. (alliedacademies.org)
- Previous experiments showed that A. actinomycetemcomitans invasion induced production of interleukin (IL)-1β, a critical inflammatory mediator in macrophages [ 6 ]. (alliedacademies.org)
Segnis1
- nov. and Aggregatibacter segnis comb. (wikipedia.org)
Biofilms3
- An important virulence property of A. actinomycetemcomitans is its ability to form tenacious biofilms that can attach to abiotic as well as biotic surfaces. (diva-portal.org)
- A. actinomycetemcomitans can form biofilms that protect it from antibiotics commonly used in periodontal therapy [ 11 ]. (biomedcentral.com)
- Sliepen I, Van Essche M, Quirynen M, Teughels W. Effect of mouthrinses on Aggregatibacter actinomycetemcomitans biofilms in a hydrodynamic model. (innovareacademics.in)
Cytolethal2
- The Aggregatibacter actinomycetemcomitans cytolethal distending toxin (Cdt) is a heterotrimeric AB 2 toxin capable of inducing cell cycle arrest and apoptosis in lymphocytes and other cell types. (frontiersin.org)
- We recently demonstrated that outer membrane vesicles (OMVs) disseminated by A. actinomycetemcomitans could deliver multiple proteins, including biologically active cytolethal distending toxin (CDT), into the cytosol of HeLa cells and human gingival fibroblasts (HGF). (asm.org)
Infection3
- The toxin kills human and primate white blood cells and likely plays a role in A. actinomycetemcomitans evasion of the immune response during infection. (grantome.com)
- The expression of the mip-like gene, prx-like gene and ompA-like gene may be enhanced in the host, and the mip-like gene may play an important role in the infection of A. actinomycetemcomitans, especially in its invasion of the epithelium. (elsevier.com)
- Read More Aggregatibacter actinomycetemcomitans: A Healthy Mouth or Systemic Infection? (thermofisher.com)
LtxA2
- The pore-forming toxin LtxA of A. actinomycetemcomitans may be a trigger of the autoimmune disease rheumatoid arthritis due to its ability to stimulate protein citrullination, a post-translational protein modification targeted by autoantibodies in this disease. (wikipedia.org)
- It has been known for quite some time that A. actinomycetemcomitans makes two toxins, the leucotoxin (LtxA) and the c ytolethal d istending t oxin (CDT), to trigger disease. (asmblog.org)
Associated with periodontal disease1
- Effects of the Aggregatibacter actinomycetemcomitans is associated with periodontal disease has been given in recent. (981heritage.com)
Subgingival2
- Samaranayake notes the evidence for the specific involvement of Aggregatibacter actinomycetemcomitans includes: an increased incidence of it found in subgingival plaque obtained from lesional sites, high level of its antibody which tends to fall following successful treatment, its possession of a wide range of potentially pathogenic products and its elimination with concordant disease regression, following treatment with successful periodontal therapy and adjunctive tetracycline . (wikipedia.org)
- Aggregatibacter actinomycetemcomitans is a gram negative coccobacillus which is prevalent in subgingival plaques. (medhelp.org)
Clinical3
- High salivary levels of JP2 genotype of Aggregatibacter actinomycetemcomitans is associated with clinical attachment loss in Moroccan adolescents. (nih.gov)
- Gingival index, probing depth, clinical attachment levels and quantitative and qualitative analysis of Aggregatibacter actinomycetemcomitans was carried out at baseline and 14 day after treatment. (hoajonline.com)
- After fourteen days, there was a statistically significant improvement in all variables including gingival index score, pocket probing depth, clinical attachment levels and reduction in colony counts of Aggregatibacter actinomycetemcomitans . (hoajonline.com)
Toxins1
- In this regard, most Cdts, including the Aggregatibacter actinomycetemcomitans Cdt are heterotrimeric holotoxins that function as AB 2 toxins. (frontiersin.org)
Strain4
- This strain had a consistent reducing effect on all subtypes of A. actinomycetemcomitans cytotoxicity, and release of IL-1β and TNF-α from PBMC´s of the blood donors. (researchsquare.com)
- Conclusions: Lactobacillus spp and L. paracasei strain SD1 in particular, showed a significant reducing interaction with A. actinomycetemcomitans toxicity and release of cytokines in vitro. (researchsquare.com)
- Cytotoxicity of PBMCs from six blood donors exposed to CWEs (100 μg/mL) of each strain of A. actinomycetemcomitans and their combination with Lactobacillus paracasei SD1. (biomedcentral.com)
- Studies demonstrate that family members commonly harbour the same strain of A. actinomycetemcomitans (10). (msdsonline.com)
Protein3
- A. actinomycetemcomitans invasion induced secretion of interleukin (IL)-1β and expression of inflammasome-associated factors, including nucleotide-binding oligomerization domain like receptor protein 3 (NLRP3), adaptor apoptosisassociated speck-like protein containing a caspase recruitment domain (ASC), caspase-1, caspase-4, and cleaved-gasdermin D (GSDMD), in THP-1 cells. (alliedacademies.org)
- A. actinomycetemcomitans' Hsp is a 64-kDa GroEL-protein, which has been shown to influence the host cells. (duhnnae.com)
- In this study we used recombinant A. actinomycetemcomitans GroEL rAaGroEL protein as a model antigen to study GroEL-mediated T cell immune response. (duhnnae.com)
Gram-negative3
- Aggregatibacter actinomycetemcomitans is a Gram-negative microorganism that is frequently isolated from patients with periodontal disease [ 1 ]. (alliedacademies.org)
- A. actinomycetemcomitans (Aa) was first reported by Klinger in 1912 where he described a previously unknown Gram-negative microorganism that was found in actinomycotic lesions associated with Actinomyces, hence the latin word "comitans" in co… 4. (981heritage.com)
- actinomycetemcomitans /em a 17-kDa peptidoglycan-associated lipoprotein (PAL) [3,4], which really is a widely conserved external membrane lipoprotein (OMLP) among Gram-negative bacterias [5]. (complextraitgenomics.com)
0.051
- actinomycetemcomitans /em vesicles (0.05C0.2 m) were larger than the filter pores and that there were no vesicles in the filtrates. (complextraitgenomics.com)
Serotypes1
- A. actinomycetemcomitans (A.a.) can be grouped into seven serotypes (a-g) [6,7]. (crimsonpublishers.com)
Vesicles2
- In the present work, we have used immunoelectron and confocal microscopy analysis and fluorescently labeled vesicles to further investigate mechanisms for A. actinomycetemcomitans OMV-mediated delivery of bacterial antigens to these host cells. (asm.org)
- Antibodies might contribute to tissue destruction by the presence of oxygen and nitrogen intermediates in periodontal A. actinomycetemcomitans have vesicles! (981heritage.com)
Intermedia1
- However, P. gingivalis was found to be more susceptible to C. roseus leaf extracts, since their growth was inhibited at relatively lower concentration as compared to A. actinomycetemcomitans and P. intermedia . (jidonline.com)
Oral cavity2
- This study tested the hypothesis that B. bacteriovorus can prey on and kill A. actinomycetemcomitans under conditions mimicking those in the oral cavity. (dentisty.org)
- A. actinomycetemcomitans is part of the normal flora of the human oral cavity and is one of the major causes of endocarditis, soft tissue infections, abscess formation, and adult and juvenile periodontis (1, 3). (msdsonline.com)
Alveolar bone1
- The mechanisms by which A. actinomycetemcomitans causes alveolar bone resorption and systemic disease are not entirely understood. (asm.org)
Genes1
- Adaptation by Ancient Horizontal Acquisition of Butyrate Metabolism Genes in Aggregatibacter actinomycetemcomitans. (upenn.edu)
Secretion1
- Docosahexaenoic acid (DHA), an omega-3 fatty acid suppressed NLRP3, ASC and caspase-1 expression as well as IL-1β secretion by THP-1 cells in response to A. actinomycetemcomitans invasion. (alliedacademies.org)
Infections such as endocarditis1
- Less frequently, A. actinomycetemcomitans is associated with nonoral infections such as endocarditis. (wikipedia.org)
Nucleatum4
- Neste estudo, as avaliações qualitativa, quantitativa e genotípica de A. actinomycetemcomitans e F. nucleatum isolados de pacientes com gengivite, periodontite crônica e indivíduos sadios foram realizadas. (usp.br)
- Os valores quantitativos de A. actinomycetemcomitans para os três grupos analisados variaram em número de cópias de 0 a 1,14 x 108, e de F. nucleatum de 0 a 3,98 x 106. (usp.br)
- Os resultados obtidos por AP-PCR mostram a heterogeneidade dos isolados de A. actinomycetemcomitans e de F. nucleatum nos diferentes grupos clínicos de pacientes avaliados. (usp.br)
- Die Arbeit untersucht die Auswirkungen einer durch P. gingivalis, F. nucleatum und A. actinomycetemcomitans ausgelösten Parodontitis auf die Kollagen-induzierte Arthritis im Mausmodell. (uni-rostock.de)