AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesInformation ScienceHealth Care
Aggregatibacter actinomycetemcomitansPasteurellaceaePasteurellaceae InfectionsActinobacillus InfectionsAggressive PeriodontitisActinobacillusExotoxinsPeriodontitisChronic PeriodontitisGingivaCampylobacter rectusPeriodontal PocketPeriodontal DiseasesDental PlaqueGingival HemorrhageTreponema denticolaFusobacterium nucleatumPrevotella intermediaPorphyromonas gingivalisDental Devices, Home CareBacterial LoadBiofilmsPeriodontiumPeri-ImplantitisAlveolar Bone LossGingivitisAggregatibacterBacterial ToxinsStreptococcus gordoniiPeriodontal IndexDental Plaque IndexAdhesins, BacterialAggregatibacter segnisMouthGingival Crevicular FluidPeriodontal Attachment LossAggregatibacter aphrophilusBacterial AdhesionBacteroidesBacterial ProteinsGene Expression Regulation, BacterialHaemophilusVirulence FactorsGram-Negative BacteriaGenome, BacterialDNA, BacterialEpithelial CellsMolecular Sequence DataPolymerase Chain ReactionHaemophilus somnusAnti-Bacterial AgentsCardiobacterium
Aggregatibacter actinomycetemcomitans
A species of Gram-negative, facultatively anaerobic spherical or rod-shaped bacteria indigenous to dental surfaces. It is associated with PERIODONTITIS; BACTERIAL ENDOCARDITIS; and ACTINOMYCOSIS.
Pasteurellaceae
A family of coccoid to rod-shaped nonsporeforming, gram-negative, nonmotile, facultatively anaerobic bacteria that includes the genera ACTINOBACILLUS; HAEMOPHILUS; MANNHEIMIA; and PASTEURELLA.
Pasteurellaceae Infections
Infections with bacteria of the family PASTEURELLACEAE.
Actinobacillus Infections
Infections with bacteria of the genus ACTINOBACILLUS.
Aggressive Periodontitis
Inflammation and loss of PERIODONTIUM that is characterized by rapid attachment loss and bone destruction in the presence of little local factors such as DENTAL PLAQUE and DENTAL CALCULUS. This highly destructive form of periodontitis often occurs in young people and was called early-onset periodontitis, but this disease also appears in old people.
Actinobacillus
A genus of PASTEURELLACEAE described as gram-negative, nonsporeforming, nonmotile, facultative anaerobes. Most members are found both as pathogens and commensal organisms in the respiratory, alimentary, and genital tracts of animals.
Exotoxins
Toxins produced, especially by bacterial or fungal cells, and released into the culture medium or environment.
Periodontitis
Inflammation and loss of connective tissues supporting or surrounding the teeth. This may involve any part of the PERIODONTIUM. Periodontitis is currently classified by disease progression (CHRONIC PERIODONTITIS; AGGRESSIVE PERIODONTITIS) instead of age of onset. (From 1999 International Workshop for a Classification of Periodontal Diseases and Conditions, American Academy of Periodontology)
Chronic Periodontitis
Chronic inflammation and loss of PERIODONTIUM that is associated with the amount of DENTAL PLAQUE or DENTAL CALCULUS present. Chronic periodontitis occurs mostly in adults and was called adult periodontitis, but this disease can appear in young people.
Gingiva
Oral tissue surrounding and attached to TEETH.
Campylobacter rectus
A species of CAMPYLOBACTER isolated from cases of human PERIODONTITIS. It is a microaerophile, capable of respiring with OXYGEN.
Periodontal Pocket
An abnormal extension of a gingival sulcus accompanied by the apical migration of the epithelial attachment and bone resorption.
Periodontal Diseases
Pathological processes involving the PERIODONTIUM including the gum (GINGIVA), the alveolar bone (ALVEOLAR PROCESS), the DENTAL CEMENTUM, and the PERIODONTAL LIGAMENT.
Dental Plaque
A film that attaches to teeth, often causing DENTAL CARIES and GINGIVITIS. It is composed of MUCINS, secreted from salivary glands, and microorganisms.
Gingival Hemorrhage
The flowing of blood from the marginal gingival area, particularly the sulcus, seen in such conditions as GINGIVITIS, marginal PERIODONTITIS, injury, and ASCORBIC ACID DEFICIENCY.
Treponema denticola
A species of bacteria in the family SPIROCHAETACEAE, frequently isolated from periodontal pockets (PERIODONTAL POCKET).
Fusobacterium nucleatum
A species of gram-negative, anaerobic, rod-shaped bacteria isolated from the gingival margin and sulcus and from infections of the upper respiratory tract and pleural cavity.
Prevotella intermedia
A species of gram-negative, anaerobic, rod-shaped bacteria originally classified within the BACTEROIDES genus. This bacterium is a common commensal in the gingival crevice and is often isolated from cases of gingivitis and other purulent lesions related to the mouth.
Porphyromonas gingivalis
A species of gram-negative, anaerobic, rod-shaped bacteria originally classified within the BACTEROIDES genus. This bacterium produces a cell-bound, oxygen-sensitive collagenase and is isolated from the human mouth.
Dental Devices, Home Care
Devices used in the home by persons to maintain dental and periodontal health. The devices include toothbrushes, dental flosses, water irrigators, gingival stimulators, etc.
Bacterial Load
Measurable quantity of bacteria in an object, organism, or organism compartment.
Biofilms
Encrustations, formed from microbes (bacteria, algae, fungi, plankton, or protozoa) embedding in extracellular polymers, that adhere to surfaces such as teeth (DENTAL DEPOSITS); PROSTHESES AND IMPLANTS; and catheters. Biofilms are prevented from forming by treating surfaces with DENTIFRICES; DISINFECTANTS; ANTI-INFECTIVE AGENTS; and antifouling agents.
Periodontium
The structures surrounding and supporting the tooth. Periodontium includes the gum (GINGIVA), the alveolar bone (ALVEOLAR PROCESS), the DENTAL CEMENTUM, and the PERIODONTAL LIGAMENT.
Peri-Implantitis
An inflammatory process with loss of supporting bone in the tissues surrounding functioning DENTAL IMPLANTS.
Alveolar Bone Loss
Resorption or wasting of the tooth-supporting bone (ALVEOLAR PROCESS) in the MAXILLA or MANDIBLE.
Gingivitis
Inflammation of gum tissue (GINGIVA) without loss of connective tissue.
Aggregatibacter
A genus of PASTEURELLACEAE. Members are nonmotile, Gram-negative, facultatively anaerobic rods or coccobacilli. Its members are X factor (HEMIN) independent and variably dependent on V factor (NAD).
Bacterial Toxins
Toxic substances formed in or elaborated by bacteria; they are usually proteins with high molecular weight and antigenicity; some are used as antibiotics and some to skin test for the presence of or susceptibility to certain diseases.
Streptococcus gordonii
A species of gram-positive, facultatively anaerobic bacteria in the family STREPTOCOCCACEAE. It is a normal inhabitant of the human oral cavity, and causes DENTAL PLAQUE and ENDOCARDITIS. It is being investigated as a vehicle for vaccine delivery.
Periodontal Index
A numerical rating scale for classifying the periodontal status of a person or population with a single figure which takes into consideration prevalence as well as severity of the condition. It is based upon probe measurement of periodontal pockets and on gingival tissue status.
Dental Plaque Index
An index which scores the degree of dental plaque accumulation.
Adhesins, Bacterial
Cell-surface components or appendages of bacteria that facilitate adhesion (BACTERIAL ADHESION) to other cells or to inanimate surfaces. Most fimbriae (FIMBRIAE, BACTERIAL) of gram-negative bacteria function as adhesins, but in many cases it is a minor subunit protein at the tip of the fimbriae that is the actual adhesin. In gram-positive bacteria, a protein or polysaccharide surface layer serves as the specific adhesin. What is sometimes called polymeric adhesin (BIOFILMS) is distinct from protein adhesin.
Aggregatibacter segnis
A species of Gram-negative, facultatively anaerobic pleomorphic rod-shaped often filamentous bacteria in the genus of AGGREGATIBACTER found in the oral cavity. It is associated with DENTAL PLAQUE; and BACTERIAL ENDOCARDITIS.
Mouth
The oval-shaped oral cavity located at the apex of the digestive tract and consisting of two parts: the vestibule and the oral cavity proper.
Gingival Crevicular Fluid
A fluid occurring in minute amounts in the gingival crevice, believed by some authorities to be an inflammatory exudate and by others to cleanse material from the crevice, containing sticky plasma proteins which improve adhesions of the epithelial attachment, have antimicrobial properties, and exert antibody activity. (From Jablonski, Illustrated Dictionary of Dentistry, 1982)
Periodontal Attachment Loss
Loss or destruction of periodontal tissue caused by periodontitis or other destructive periodontal diseases or by injury during instrumentation. Attachment refers to the periodontal ligament which attaches to the alveolar bone. It has been hypothesized that treatment of the underlying periodontal disease and the seeding of periodontal ligament cells enable the creating of new attachment.
Aggregatibacter aphrophilus
A species of Gram-negative, facultatively anaerobic spherical or rod-shaped bacteria indigenous to oral cavity and pharynx. It is associated with BACTERIAL ENDOCARDITIS; and MENINGITIS.
Bacterial Adhesion
Physicochemical property of fimbriated (FIMBRIAE, BACTERIAL) and non-fimbriated bacteria of attaching to cells, tissue, and nonbiological surfaces. It is a factor in bacterial colonization and pathogenicity.
Bacteroides
A genus of gram-negative, anaerobic, rod-shaped bacteria. Its organisms are normal inhabitants of the oral, respiratory, intestinal, and urogenital cavities of humans, animals, and insects. Some species may be pathogenic.
Bacterial Proteins
Proteins found in any species of bacterium.
Gene Expression Regulation, Bacterial
Any of the processes by which cytoplasmic or intercellular factors influence the differential control of gene action in bacteria.
Haemophilus
A genus of PASTEURELLACEAE that consists of several species occurring in animals and humans. Its organisms are described as gram-negative, facultatively anaerobic, coccobacillus or rod-shaped, and nonmotile.
Virulence Factors
Those components of an organism that determine its capacity to cause disease but are not required for its viability per se. Two classes have been characterized: TOXINS, BIOLOGICAL and surface adhesion molecules that effect the ability of the microorganism to invade and colonize a host. (From Davis et al., Microbiology, 4th ed. p486)
Gram-Negative Bacteria
Bacteria which lose crystal violet stain but are stained pink when treated by Gram's method.
Genome, Bacterial
The genetic complement of a BACTERIA as represented in its DNA.
DNA, Bacterial
Deoxyribonucleic acid that makes up the genetic material of bacteria.
Epithelial Cells
Cells that line the inner and outer surfaces of the body by forming cellular layers (EPITHELIUM) or masses. Epithelial cells lining the SKIN; the MOUTH; the NOSE; and the ANAL CANAL derive from ectoderm; those lining the RESPIRATORY SYSTEM and the DIGESTIVE SYSTEM derive from endoderm; others (CARDIOVASCULAR SYSTEM and LYMPHATIC SYSTEM) derive from mesoderm. Epithelial cells can be classified mainly by cell shape and function into squamous, glandular and transitional epithelial cells.
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Polymerase Chain Reaction
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
Haemophilus somnus
A species of gram-negative bacteria (currently incertae sedis) causing multisystem disease in CATTLE.
Anti-Bacterial Agents
Substances that reduce the growth or reproduction of BACTERIA.
Cardiobacterium
A genus of gram-negative, facultatively anaerobic bacteria in the family CARDIOBACTERIACEAE. It is found in the nasal flora of humans and causes ENDOCARDITIS.

Identification of a cytolethal distending toxin gene locus and features of a virulence-associated region in Actinobacillus actinomycetemcomitans. (1/397)

A genetic locus for a cytolethal distending toxin (CDT) was identified in a polymorphic region of the chromosome of Actinobacillus actinomycetemcomitans, a predominant oral pathogen. The locus was comprised of three open reading frames (ORFs) that had significant amino acid sequence similarity and more than 90% sequence identity to the cdtABC genes of some pathogenic Escherichia coli strains and Haemophilus ducreyi, respectively. Sonic extracts from recombinant E. coli, containing the A. actinomycetemcomitans ORFs, caused the distension and killing of Chinese hamster ovary cells characteristic of a CDT. Monoclonal antibodies made reactive with the CdtA, CdtB, and CdtC proteins of H. ducreyi recognized the corresponding gene products from the recombinant strain. CDT-like activities were no longer expressed by the recombinant strain when an OmegaKan-2 interposon was inserted into the cdtA and cdtB genes. Expression of the CDT-like activities in A. actinomycetemcomitans was strain specific. Naturally occurring expression-negative strains had large deletions within the region of the cdt locus. The cdtABC genes were flanked by an ORF (virulence plasmid protein), a partial ORF (integrase), and DNA sequences (bacteriophage integration site) characteristic of virulence-associated regions. These results provide evidence for a functional CDT in a human oral pathogen.  (+info)

Actinobacillus actinomycetemcomitans immunosuppressive protein is a member of the family of cytolethal distending toxins capable of causing a G2 arrest in human T cells. (2/397)

We have previously shown that Actinobacillus actinomycetecomitans produces an immunosuppressive factor (ISF) capable of impairing human lymphocyte function by perturbing cell cycle progression. We now report that ISF is the product of the cdtB gene, one of three genes encoding the family of cytolethal distending toxins (Cdt). The ISF polypeptide exhibits >/=95% identity with Hemophilus ducreyi CdtB protein and +info)

Identification and molecular analysis of rough-colony-specific outer membrane proteins of Actinobacillus actinomycetemcomitans. (3/397)

Actinobacillus actinomycetemcomitans, a gram-negative bacterium isolated from the human mouth, has been implicated in the pathogenesis of early-onset periodontitis. Primary isolates cultured from subgingival plaque exhibit an adherent, rough colony phenotype which spontaneously converts to a nonadherent, smooth phenotype upon in vitro subculture. The rough colony variant produces abundant fimbriae and autoaggregates, while the smooth colony variant is planktonic and produces scant fimbriae. To begin to understand the significance of colony variation in biofilm formation by A. actinomycetemcomitans, outer membrane protein profiles of four isogenic rough and smooth colony variants were compared by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Two proteins with relative molecular masses of 43 and 20 kDa were expressed by the rough colony variants exclusively. Expression of these proteins was not found to be dependent on growth phase, oxygen tension, or type of complex medium. N-terminal amino acid sequences of these proteins obtained by Edman degradation were compared with sequences from the University of Oklahoma A. actinomycetemcomitans genome database. Two contiguous open reading frames (ORFs) encoding proteins having sequence homology with these proteins were identified. The 43-kDa protein (RcpA [rough colony protein A]) was similar to precursor protein D of the general secretion pathway of gram-negative bacilli, while the 20-kDa protein (RcpB [rough colony protein B]) appeared to be unique. The genes encoding these proteins have been cloned from A. actinomycetemcomitans 283 and sequenced. A BLASTX (gapped BLAST) search of the surrounding ORFs revealed homology with other fimbria-related proteins. These data suggest that the genes encoding the 43-kDa (rcpA) and 20-kDa (rcpB) proteins may be functionally related to each other and to genes that may encode fimbria-associated proteins.  (+info)

A novel NDP-6-deoxyhexosyl-4-ulose reductase in the pathway for the synthesis of thymidine diphosphate-D-fucose. (4/397)

The serotype-specific polysaccharide antigen of Actinobacillus actinomycetemcomitans Y4 (serotype b) consists of D-fucose and L-rhamnose. Thymidine diphosphate (dTDP)-D-fucose is the activated nucleotide sugar form of D-fucose, which has been identified as a constituent of structural polysaccharides in only a few bacteria. In this paper, we show that three dTDP-D-fucose synthetic enzymes are encoded by genes in the gene cluster responsible for the synthesis of serotype b-specific polysaccharide in A. actinomycetemcomitans. The first and second steps of the dTDP-D-fucose synthetic pathway are catalyzed by D-glucose-1-phosphate thymidylyltransferase and dTDP-D-glucose 4,6-dehydratase, which are encoded by rmlA and rmlB in the gene cluster, respectively. These two reactions are common to the well studied dTDP-L-rhamnose synthetic pathway. However, the enzyme catalyzing the last step of the dTDP-D-fucose synthetic pathway has never been reported. We identified the fcd gene encoding a dTDP-4-keto-6-deoxy-D-glucose reductase. After purifying the three enzymes, their enzymatic activities were analyzed by reversed-phase high performance liquid chromatography. In addition, nuclear magnetic resonance analysis and gas-liquid chromatography analysis proved that the fcd gene product converts dTDP-4-keto-6-deoxy-D-glucose to dTDP-D-fucose. Moreover, kinetic analysis of the enzyme indicated that the Km values for dTDP-4-keto-6-deoxy-D-glucose and NADPH are 97.3 and 28.7 microM, respectively, and that the enzyme follows the sequential mechanism. This paper is the first report on the dTDP-D-fucose synthetic pathway and dTDP-4-keto-6-deoxy-D-glucose reductase.  (+info)

Improved multiplex PCR using conserved and species-specific 16S rRNA gene primers for simultaneous detection of Actinobacillus actinomycetemcomitans, Bacteroides forsythus, and Porphyromonas gingivalis. (5/397)

Among putative periodontal pathogens, Actinobacillus actinomycetemcomitans, Bacteroides forsythus, and Porphyromonas gingivalis are most convincingly implicated as etiological agents in periodontitis. Therefore, techniques for detection of those three species would be of value. We previously published a description of a multiplex PCR that detects A. actinomycetemcomitans and P. gingivalis. The present paper presents an improvement on that technique, which now allows more sensitive detection of all three periodontal pathogens. Sensitivity was determined by testing serial dilutions of A. actinomycetemcomitans, B. forsythus, and P. gingivalis cells. Primer specificity was tested against (i) all gene sequences from the GenBank-EMBL database, (ii) six A. actinomycetemcomitans, one B. forsythus, and four P. gingivalis strains, (iii) eight different species of oral bacteria, and (iv) supra- and subgingival plaque samples from 20 healthy subjects and subgingival plaque samples from 10 patients with periodontitis. The multiplex PCR had a detection limit of 10 A. actinomycetemcomitans, 10 P. gingivalis, and 100 B. forsythus cells. Specificity was confirmed by the fact that (i) none of our forward primers were homologous to the 16S rRNA genes of other oral species, (ii) amplicons of predicted size were detected for all A. actinomycetemcomitans, B. forsythus, and P. gingivalis strains tested, and (iii) no amplicons were detected for the eight other bacterial species. A. actinomycetemcomitans, B. forsythus, and P. gingivalis were detected in 6 of 20, 1 of 20, and 11 of 20 of supragingival plaque samples, respectively, and 4 of 20, 7 of 20, and 13 of 20 of subgingival plaque samples, respectively, from periodontally healthy subjects. Among patients with periodontitis, the organisms were detected in 7 of 10, 10 of 10, and 7 of 10 samples, respectively. The simultaneous detection of three periodontal pathogens is an advantage of this technique over conventional PCR assays.  (+info)

Identification of genes coding for exported proteins of Actinobacillus actinomycetemcomitans. (6/397)

Random fusions of genomic DNA fragments to a partial gene encoding a signal sequence-deficient bacterial alkaline phosphatase were utilized to screen for exported proteins of Actinobacillus actinomycetemcomitans in Escherichia coli. Twenty-four PhoA(+) clones were isolated and sequenced. Membrane localization signals in the form of signal sequences were deduced from most of these sequences. Several of the deduced amino acid sequences were found to be homologous to known exported or membrane-associated proteins. The complete genes corresponding to two of these sequences were isolated from an A. actinomycetemcomitans lambda phage library. One gene was found to be homologous to the outer membrane lipoprotein LolB. The second gene product had homology with a Haemophilus influenzae protein and was localized to the inner membrane of A. actinomycetemcomitans.  (+info)

Microtubules are associated with intracellular movement and spread of the periodontopathogen Actinobacillus actinomycetemcomitans. (7/397)

Actinobacillus actinomycetemcomitans SUNY 465, the invasion prototype strain, enters epithelial cells by an actin-dependent mechanism, escapes from the host cell vacuole, and spreads intracellularly and to adjacent epithelial cells via intercellular protrusions. Internalized organisms also egress from host cells into the assay medium via protrusions that are associated with just a single epithelial cell. Here we demonstrate that agents which inhibit microtubule polymerization (e.g., colchicine) and those which stabilize polymerized microtubules (e.g., taxol) both increase markedly the number of intracellular A. actinomycetemcomitans organisms. Furthermore, both colchicine and taxol prevented the egression of A. actinomycetemcomitans from host cells into the assay medium. Immunofluorescence microscopy revealed that protrusions that mediate the bacterial spread contain microtubules. A. actinomycetemcomitans SUNY 465 and 652, strains that are both invasive and egressive, interacted specifically with the plus ends (growing ends) of the filaments of microtubule asters in a KB cell extract. By contrast, neither A. actinomycetemcomitans 523, a strain that is invasive but not egressive, nor Haemophilus aphrophilus, a noninvasive oral bacterium with characteristics similar to those of A. actinomycetemcomitans, bound to microtubules. Together these data suggest that microtubules function in the spread and movement of A. actinomycetemcomitans and provide the first evidence that host cell dispersion of an invasive bacterium may involve the usurption of host cell microtubules.  (+info)

Direct selection of IS903 transposon insertions by use of a broad-host-range vector: isolation of catalase-deficient mutants of Actinobacillus actinomycetemcomitans. (8/397)

Transposon mutagenesis in bacteria generally requires efficient delivery of a transposon suicide vector to allow the selection of relatively infrequent transposition events. We have developed an IS903-based transposon mutagenesis system for diverse gram-negative bacteria that is not limited by transfer efficiency. The transposon, IS903phikan, carries a cryptic kan gene, which can be expressed only after successful transposition. This allows the stable introduction of the transposon delivery vector into the host. Generation of insertion mutants is then limited only by the frequency of transposition. IS903phikan was placed on an IncQ plasmid vector with the transposase gene located outside the transposon and expressed from isopropyl-beta-D-thiogalactopyranoside (IPTG)-inducible promoters. After transposase induction, IS903phikan insertion mutants were readily selected in Escherichia coli by their resistance to kanamycin. We used IS903phikan to isolate three catalase-deficient mutants of the periodontal pathogen Actinobacillus actinomycetemcomitans from a library of random insertions. The mutants display increased sensitivity to hydrogen peroxide, and all have IS903phikan insertions within an open reading frame whose predicted product is closely related to other bacterial catalases. Nucleotide sequence analysis of the catalase gene (designated katA) and flanking intergenic regions also revealed several occurrences of an 11-bp sequence that is closely related to the core DNA uptake signal sequence for natural transformation of Haemophilus influenzae. Our results demonstrate the utility of the IS903phikan mutagenesis system for the study of A. actinomycetemcomitans. Because IS903phikan is carried on a mobilizable, broad-host-range IncQ plasmid, this system is potentially useful in a variety of bacterial species.  (+info)

Natural Transformation and DNA Uptake Signal Sequences in Actinobacillus actinomycetemcomitans | Journal of BacteriologyNatural Transformation and DNA Uptake Signal Sequences in Actinobacillus actinomycetemcomitans | Journal of Bacteriology
Two previous studies have observed natural transformation in A. actinomycetemcomitans. Tøonjum et al. (30) used a broth-based method and identified two naturally competent strains among five study strains of A. actinomycetemcomitans with transformation frequencies of 1.3 × 10−3 and 6.2 × 10−5. In our present study, we identified a single highly competent A. actinomycetemcomitans strain among 17 strains examined. Although this is an apparently lower prevalence of naturally competent A. actinomycetemcomitans strains than was reported by Tøonjum et al., the transformation frequencies reported in this study were similar.. Sato et al. (23) generated transposon insertional mutants from the A. actinomycetemcomitans strain Y4 by natural transformation. The transformation was performed with broth-cultured exponential-phase A. actinomycetemcomitans cells. However, strain Y4 was not transformable in our study. While the loss of competence is sometimes a consequence of laboratory propagation, it is ...
https://jb.asm.org/content/184/13/3442?ijkey=bccda1452eeaeaa3ee1efcf2e65f619680ed145d&keytype2=tf_ipsecsha
Serum immunoglobulin G subclass concentrations in periodontally healthy and diseased individuals. | Infection and ImmunitySerum immunoglobulin G subclass concentrations in periodontally healthy and diseased individuals. | Infection and Immunity
Patients with localized juvenile periodontitis (LJP) often have high titers of antibody reactive with the serotype-specific immunodominant carbohydrate antigen of Actinobacillus actinomycetemcomitans serotype b. The vast majority of this A. actinomycetemcomitans serotype b-specific antibody is immunoglobulin G2 (IgG2). The present study was undertaken to determine whether the overall total levels of IgG2 in the sera of LJP patients are elevated. LJP patients and nonperiodontitis (NP) controls matched for age, race (black and white), and gender were studied. Additional controls included patients with adult periodontitis (AP) and patients similar in age to LJP patients but with the more-severe, generalized form of early-onset periodontitis (SP). Sera from over 700 periodontally characterized subjects were examined by using radial immunodiffusion to quantitate IgG2 as well as IgG1, -3, and -4, which were included for comparison. Serum IgG2 levels increased with age, and this was most dramatic ...
https://iai.asm.org/content/62/5/1677
Molecular pathogenicity of the oral opportunistic pathogen Actinobacillus actinomycetemcomitansMolecular pathogenicity of the oral opportunistic pathogen Actinobacillus actinomycetemcomitans
Periodontitis is mankinds most common chronic inflammatory disease. One severe form of periodontitis is localized aggressive periodontitis (LAP), a condition to which individuals of African origin demonstrate an increased susceptibility. The main causative organism of this disease is Actinobacillus …
https://pubmed.ncbi.nlm.nih.gov/14527274/?dopt=Abstract
Caspase 1 involvement in human monocyte lysis induced by Actinobacillus actinomycetemcomitans leukotoxinCaspase 1 involvement in human monocyte lysis induced by Actinobacillus actinomycetemcomitans leukotoxin
Aggregatibacter (Actinobacillus) actinomycetemcomitans is a bacterium mainly associated with aggressive forms of periodontitis. Among its virulence factors, a leukotoxin is suggested to play an important role in the pathogenicity. Periodontal infections with strains producing high levels of the leukotoxin are strongly associated with severe disease. Leukotoxin selectively kills human leukocytes and can disrupt the local defense mechanisms. Previous studies examining the role of the leukotoxin in host-parasite interactions have mainly focused on polymorphonuclear leukocytes (PMNs). In the inflamed periodontium, macrophages play a significant role in the regulation of the inflammatory reactions and the tissue breakdown and remodeling.. Thus, the aim of this dissertation was to investigate death mechanisms of human macrophages exposed to leukotoxin.. Human lymphocytes, PMNs, and monocytes/macrophages isolated from venous blood were exposed to purified leukotoxin or live A. actinomycetemcomitans ...
http://umu.diva-portal.org/smash/record.jsf?pid=diva2%3A146154&c=28&searchType=SIMPLE&language=sv&query=&af=%5B%5D&aq=%5B%5B%7B%22personId%22%3A%22authority-person%3A65531%22%7D%5D%5D&aq2=%5B%5B%5D%5D&aqe=%5B%5D&noOfRows=50&sortOrder=author_sort_asc&sortOrder2=title_sort_asc&onlyFullText=false&sf=all
aggregatibacter actinomycetemcomitans periodontal disease
Aggregatibacter actinomycetemcomitans (A.a) serotypes may add some important information of the pathogenetic background of periodontal infections. (adsbygoogle = window.adsbygoogle ,, []).push({}); When grown in culture, these form small colonies, approximately 0.5-1.0 mm in diameter. The cytotoxin produced by, Almost all strains of A. actinomycetemcomitans have these vesicles. 2008 Apr 1;10(5):489-96. The results of the study showed that these antibodies might contribute to limit the systemic effects of the infection. Ltx B and Ltx D are involved in transporting the toxin to the surface of the cell while Ltx C post-transitionally activates the toxin. The most common bacteria involved in periodontal pathologies of young individuals and in cases of refractory adult periodontitis is Aggregatibacter actinomycetemcomitans. This genus includes Gram-negative, non-motile, facultatively anaerobic rods or coccobacilli that were previously known as Haemophilus. The active subunit, CdtB, exhibits DNase I ...
http://981heritage.com/i6mgeoia/aggregatibacter-actinomycetemcomitans-periodontal-disease-fda1a2
Aggregatibacter actinomycetemcomitans (Klinger 1912) Nørskov-LauritsenAggregatibacter actinomycetemcomitans (Klinger 1912) Nørskov-Lauritsen
Aggregatibacter actinomycetemcomitans ATCC ® 700685D-5™ Designation: Genomic DNA from Aggregatibacter actinomycetemcomitans strain HK1651 TypeStrain=False Application:
https://www.atcc.org/en/Products/Nucleic_Acid_Proteins_and_Cell_Extracts/Genomic_DNA_and_RNA/From_Bacteria/700685D-5.aspx
Aggregatibacter actinomycetemcomitans (Klinger 1912) Nørskov-LauritsenAggregatibacter actinomycetemcomitans (Klinger 1912) Nørskov-Lauritsen
Aggregatibacter actinomycetemcomitans ATCC ® 700685D-5™ Designation: Genomic DNA from Aggregatibacter actinomycetemcomitans strain HK1651 TypeStrain=False Application:
https://www.atcc.org/Products/All/700685D-5.aspx
Structures of the antigenic O-polysaccharides of lipopolysaccharides produced by Actinobacillus actinomycetemcomitans serotypes...
Structures of the antigenic O-polysaccharides of lipopolysaccharides produced by Actinobacillus actinomycetemcomitans serotypes a, c, d and e
http://nparc.cisti-icist.nrc-cnrc.gc.ca/eng/view/object/?id=0bb3780b-5afa-483e-8aa9-624e7f4bca11
Targeted delivery of a photosensitizer to Aggregatibacter actinomycetemcomitans biofilm - Zurich Open Repository and ArchiveTargeted delivery of a photosensitizer to Aggregatibacter actinomycetemcomitans biofilm - Zurich Open Repository and Archive
The ability to selectively target specific biofilm species with antimicrobials would enable control over biofilm consortium composition, with medical applications in treatment of infections on mucosal surfaces that are colonized by a mixture of beneficial and pathogenic microorganisms. We functionalized a genetically engineered multimeric protein with both a targeting moiety (biotin) and either a fluorophore or a photosensitizer (SnCe6). Biofilm microcolonies of Aggregatibacter actinomycetemcomitans, a periodontal pathogen, were targeted with the multifunctional dodecamer. Streptavidin was used to couple biotinylated dodecamer to a biotinylated anti-A. actinomycetemcomitans antibody. This modular targeting approach enabled us to increase the loading of photosensitizer onto the cells by a cycle of amplification. Scanning laser confocal microscopy was used to characterize transport of fluorescently tagged dodecamer into the microcolonies and targeting of the cells with biotin-labeled, ...
http://www.zora.uzh.ch/id/eprint/42943/
Cytotoxic mechanisms of Aggregatibacter actinomycetemcomitans leukotoxin - Angela BrownCytotoxic mechanisms of Aggregatibacter actinomycetemcomitans leukotoxin - Angela Brown
Aggregatibacter actinomycetemcomitans is a Gram-negative pathogen that is the etiologic agent of localized aggressive periodontitis (LAP) and other systemic inf...
http://grantome.com/grant/NIH/R00-DE022795-03
ANTIMICROBIAL AND ANTIBIOFILM ACTIVITY OF CATHELICIDINS - Patent applicationANTIMICROBIAL AND ANTIBIOFILM ACTIVITY OF CATHELICIDINS - Patent application
0165] (1) Wilson M, Henderson, B. Virulence factors of A. actinomycetemcomitans revenant to the pathogenesis of inflammatory periodontal diseases. FEMS 1995:17:365-379. [0166] (2) Nowotny A, Behling U H, Hammond B, et al. Release of toxic microvesicles by Actinobacillus actinomycetemcomitans. Infect Immun 1982:37:151-154. [0167] (3) Kaplan J B, Perry M B, MacLean L L, Furgang D, Wilson M E, Fine D H. Structural and genetic analyses of 0 polysaccharide from Actinobacillus actinomycetemcomitans serotype f. Infect Immun 2001:69:5375-5384. [0168] (4) Rosan B, Slots J, Lamont R J, Listgarten M A, Nelson G M. Actinobacillus actinomycetemcomitans fimbriae. Oral Microbiol Immunol 1988:3:58-63. [0169] (5) Inouye T, Ohta H, Kokeguchi S, Fukui K, Kato K. Colonial variation and fimbriation of Actinobacillus actinomycetemcomitans. FEMS microbiology letters 1990: 57: 13-17. [0170] (6) Kaplan J B, Schreiner H C, Furgang D, Fine D H. Population structure and genetic diversity of Actinobacillus ...
http://www.patentsencyclopedia.com/app/20120149631
Infection by Porphyromonas gingivalis and Actinobacillus actinomycetemcomitans, and antibody responses at different ages in...
TY - JOUR. T1 - Infection by Porphyromonas gingivalis and Actinobacillus actinomycetemcomitans, and antibody responses at different ages in humans.. AU - Nakagawa, S.. AU - Machida, Y.. AU - Nakagawa, Taneaki. AU - Fujii, H.. AU - Yamada, S.. AU - Takazoe, I.. AU - Okuda, K.. PY - 1994/1. Y1 - 1994/1. N2 - This study examined the serum IgG and IgM responses against Porphyromonas gingivalis and 3 serotypes of Actinobacillus actinomycetemcomitans, and the correlations of these responses with age and homologous infection. A total of 90 individuals were included in this study: 40 subjects with gingivitis, 40 periodontally healthy subjects, and 10 adult periodontitis subjects. The subjects in the gingivitis and periodontally healthy groups were divided into 4 stages based on their physiological age: early childhood, school age, puberty, and adult. In the gingivitis group, there was a positive correlation between increase in age and increase in serum IgG antibody levels against P. gingivalis until ...
https://keio.pure.elsevier.com/en/publications/infection-by-porphyromonas-gingivalis-and-actinobacillus-actinomy
Cell surface-associated enolase in Actinobacillus actinomycetemcomitans<...
TY - JOUR. T1 - Cell surface-associated enolase in Actinobacillus actinomycetemcomitans. AU - Hara, Hiroaki. AU - Ohta, Hiroyuki. AU - Inoue, Tetsuyoshi. AU - Ohashi, Toshio. AU - Takashiba, Shogo. AU - Murayama, Yoji. AU - Fukui, Kazuhiro. PY - 2000. Y1 - 2000. N2 - Cell surface-associated materials of Actinobacillus actinomycetemcomitans were extracted by a short incubation of the cell suspension in a Tris-buffered saline in the presence and absence of a restriction enzyme, EcoRI. The supernatants (which we termed EcoRI extract and surface extract, respectively) contained a number of extracellularly released proteins. Of these proteins, four major proteins were identified by N-terminal sequencing to be the 34 and 39 kDa outer membrane proteins, the GroEL-like protein, and a 47 kDa protein homologous to Haemophilus influenzae enolase. Enolase activity was found in the extracts and its relative amount of activity in the EcoRI extract from a culture of the mid-exponential growth phase was ...
https://okayama.pure.elsevier.com/en/publications/cell-surface-associated-enolase-in-actinobacillus-actinomycetemco
Aggregatibacter actinomycetemcomitans H-NS promotes biofilm formation and alters protein dynamics of other species within a...Aggregatibacter actinomycetemcomitans H-NS promotes biofilm formation and alters protein dynamics of other species within a...
Aggregatibacter actinomycetemcomitans is a Gram-negative organism, strongly associated with aggressive forms of periodontitis. An important virulence property of A. actinomycetemcomitans is its ability to form tenacious biofilms that can attach to abiotic as well as biotic surfaces. The histone-like (H-NS) family of nucleoid-structuring proteins act as transcriptional silencers in many Gram-negative bacteria. To evaluate the role of H-NS in A. actinomycetemcomitans, hns mutant derivatives of serotype a strain D7S were generated. Characteristics of the hns mutant phenotype included shorter and fewer pili, and substantially lower monospecies biofilm formation relative to the wild type. Furthermore, the D7S hns mutant exhibited significantly reduced growth within a seven-species oral biofilm model. However, no apparent difference was observed regarding the numbers and proportions of the remaining six species regardless of being co-cultivated with D7S hnsor its parental strain. Proteomics analysis ...
http://umu.diva-portal.org/smash/record.jsf?pid=diva2%3A1213639&c=47&searchType=SIMPLE&language=sv&query=&af=%5B%5D&aq=%5B%5B%7B%22categoryId%22%3A%2211659%22%7D%5D%5D&aq2=%5B%5B%5D%5D&aqe=%5B%5D&noOfRows=50&sortOrder=author_sort_asc&sortOrder2=title_sort_asc&onlyFullText=false&sf=all
The Actinobacillus actinomycetemcomitans Ribose Binding Protein RbsB Interacts with Cognate and Heterologous Autoinducer 2...The Actinobacillus actinomycetemcomitans Ribose Binding Protein RbsB Interacts with Cognate and Heterologous Autoinducer 2...
Many gram-positive and gram-negative bacterial species express LuxS and secrete and respond in various ways to a signal that is related to autoinducer 2 of V. harveyi (4, 7, 9, 10, 14, 16, 18, 19, 20, 21, 30, 31, 41). However, few of these organisms possess the dedicated two-component circuit that mediates the cell density-dependent response of V. harveyi to AI-2. Our previous studies showed that AI-2 secreted by the oral pathogen A. actinomycetemcomitans was capable of inducing V. harveyi bioluminescence (10) and also influenced aerobic growth of A. actinomycetemcomitans under iron-limiting conditions (9) These studies also suggested that AI-2-mediated regulation of iron uptake and storage genes contributed to optimal growth of A. actinomycetemcomitans under iron limitation. However, the mechanism by which A. actinomycetemcomitans responds to AI-2 is not fully understood. Analysis of the complete genome sequence of A. actinomycetemcomitans HK1651 (26; www.oralgen.lanl.gov ) indicates that this ...
https://iai.asm.org/content/74/7/4021?ijkey=0067598153cceb03029c010b7ee2d535e1066623&keytype2=tf_ipsecsha
Cytolethal distending toxin in isolates of Aggregatibacter actinomycetemcomitans from Ghanaian adolescents and association with...Cytolethal distending toxin in isolates of Aggregatibacter actinomycetemcomitans from Ghanaian adolescents and association with...
Adolescent; Aggregatibacter actinomycetemcomitans; Bacterial Toxins; Cohort Studies; Cross-Sectional Studies; DNA, Bacterial; Disease Progression; Ghana; Humans; Pasteurellaceae Infections; Periodontal Diseases ...
http://www.forskningsdatabasen.dk/catalog/244160943
Aggregatibacter actinomycetemcomitans GroEL Protein Promotes Conversion of Human CD4 T Cells into IFNγ IL10 Producing Tbet Th1...
Aggregatibacter actinomycetemcomitans GroEL Protein Promotes Conversion of Human CD4 T Cells into IFNγ IL10 Producing Tbet Th1 Cells. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
http://libros.duhnnae.com/2017/jun7/149818595765-Aggregatibacter-actinomycetemcomitans-GroEL-Protein-Promotes-Conversion-of-Human-CD4-T-Cells-into-IFN-IL10-Producing-Tbet-Th1-Cells.php
UniProt/TrEMBL: C9R3L9 AGGAD
ID C9R3L9_AGGAD Unreviewed; 404 AA. AC C9R3L9; DT 24-NOV-2009, integrated into UniProtKB/TrEMBL. DT 24-NOV-2009, sequence version 1. DT 25-OCT-2017, entry version 39. DE SubName: Full=Molybdopterin molybdenumtransferase {ECO:0000313,EMBL:ACX82405.1}; GN OrderedLocusNames=D11S_1018 {ECO:0000313,EMBL:ACX82405.1}; OS Aggregatibacter actinomycetemcomitans serotype C (strain D11S-1) OS (Actinobacillus actinomycetemcomitans). OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales; OC Pasteurellaceae; Aggregatibacter. OX NCBI_TaxID=668336 {ECO:0000313,EMBL:ACX82405.1, ECO:0000313,Proteomes:UP000002569}; RN [1] {ECO:0000313,EMBL:ACX82405.1, ECO:0000313,Proteomes:UP000002569} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=D11S-1 {ECO:0000313,EMBL:ACX82405.1, RC ECO:0000313,Proteomes:UP000002569}; RX PubMed=19820097; DOI=10.1128/JB.01203-09; RA Chen C., Kittichotirat W., Si Y., Bumgarner R.; RT Genome sequence of Aggregatibacter actinomycetemcomitans serotype c RT strain D11S-1.; ...
http://www.genome.jp/dbget-bin/www_bget?tr:C9R3L9_AGGAD
A. actinomycetemcomitans b Antibody (141AA1) - DSHBA. actinomycetemcomitans b Antibody (141AA1) - DSHB
Monoclonal antibody against Aggregatibacter actinomycetemcomitans serotype b expressed by for use in Western Blot against gram-negative bacteria
http://dshb.biology.uiowa.edu/Aggregatibacter-actinomycetemcomitans-serotype-b
KEGG GENOME: Aggregatibacter actinomycetemcomitans D11S-1
A major etiologic agent of human periodontal disease. This strain was recovered from the subgingival plaque of a patient diagnosed with generalized aggressive periodontitis ...
http://www.genome.jp/kegg-bin/show_organism?org=aat
Tryptic Soy-Serum-Bacitracin-Vancomycin Agar - TSBV - Anaerobe SystemsTryptic Soy-Serum-Bacitracin-Vancomycin Agar - TSBV - Anaerobe Systems
TSBV agar is an enriched selective medium used for the isolation of Aggregatibacter actinomycetemcomitans from clinical specimens. The nutritive base consists of casein, soy peptone, and yeast extract. Sodium chloride is added to maintain osmotic equilibrium of the media. Serum is included to enhance the recovery of Aggregatibacter actinomycetemcomitans. The selective agents include bacitracin and vancomycin at concentrations that inhibit most gram-positive and gram-negative anaerobes. This media is prepared, dispensed, and packaged under oxygen-free conditions to prevent the formation of oxidized products prior to use.. ...
https://anaerobesystems.com/products/plated-media/tryptic-soy-serum-bacitracin-vancomycin-agar-tsbv/
Oral lactobacilli reduce cytotoxicity and cytokine release from peripheral blood mononuclear cells exposed to Aggregatibacter...Oral lactobacilli reduce cytotoxicity and cytokine release from peripheral blood mononuclear cells exposed to Aggregatibacter...
Background: This study evaluated the effect of oral lactobacilli on the cytotoxicity and cytokine release from peripheral blood mononuclear cells (PBMC) when exposed to Aggregatibacter actinomycetemcomitans subtypes in vitro. The supernatants and cell wall extracts (CWEs) of eight A. actinomyc...
https://www.researchsquare.com/article/rs-16413/v1
Faculty Details | Department of Microbiology and Molecular GeneticsFaculty Details | Department of Microbiology and Molecular Genetics
The focus of my research is the identification and characterization of bacterial proteins that are required for tissue colonization, the initiation of any infection. My research interests are concentrated on the membrane proteins and surface structures of the Gram-negative bacterium Aggregatibacter actinomycetemcomitans. A. actinomycetemcomitans is typically associated with Periodontitis, an inflammatory disease of the tissues surrounding and supporting the teeth, which left untreated results in tooth loss. This bacterium is also associated with numerous non-oral diseases including but not restricted to infective endocarditis and atherosclerosis, which suggest that the periodontal pocket is a potential source and reservoir of these diseases. The emphasis of my research is based on two genes and the associated proteins identified in my laboratory. We have identified and characterized a unique collagen adhesin expressed by A. actinomycetemcomitans. The extracellular matrix protein adhesin A (EmaA) ...
http://www.uvm.edu/microbiology/directory/mmg-faculty-directory/faculty-details/?people_id=101
LILACS - Resultado p gina 1
A Periodontite Agressiva (PA), que atualmente pertence ao grupo das Periodontites est gios 3 e 4, distingue-se dos demais tipos de doen a periodontal por seu in cio precoce, agrega o familiar dos casos e por afetar pacientes sistemicamente saud veis. Al m disso, pode ser subclassificada em duas formas, localizada (PAL) e generalizada (PAG), em fun o de sua extens o. Muitas vezes, os dep sitos de biofilme bacteriano s o desproporcionais quantidade de destrui o ssea e perda de inser o que o paciente apresenta, independente da subclassifica o. O microrganismo mais relacionado etiopatog nese da doen a o Aggregatibacter actinomycetemcomitans (A. actinomycetemcomitans), incluindo os seus principais sorotipos a, b e c, amplamente estudados. Associado a estas condi es, A. actinomycetemcomitans apresenta alguns fatores de virul ncia como uma leucotoxina, principalmente ligada ao sorotipo b - clone JP2 (que altamente leucot xico) e prote nas de membrana externa (OMPs), especialmente Omp29. A resposta de ...
http://bases.bireme.br/cgi-bin/wxislind.exe/iah/online/?IsisScript=iah/iah.xis&nextAction=lnk&base=LILACS&lang=p&format=detailed.pft&indexSearch=EX&exprSearch=B03.440.450.600.224.500
Researchers Add to Evidence That Common Bacterial Cause of Gum Disease May Drive Rheumatoid Arthritis :: By :: Article ::...Researchers Add to Evidence That Common Bacterial Cause of Gum Disease May Drive Rheumatoid Arthritis :: By :: Article ::...
Johns Hopkins Medicine (JHM). December 14, 2016. Investigators at Johns Hopkins report they have new evidence that a bacterium known to cause chronic inflammatory gum infections also triggers the inflammatory autoimmune response characteristic of chronic, joint-destroying rheumatoid arthritis (RA). The new findings have important implications for prevention and treatment of RA, say the researchers.. In a report on the work, published in the Dec. 14 edition of the journal Science Translational Medicine, the investigators say the common denominator they identified in periodontal disease (gum disease) and in many people with RA is Aggregatibacter actinomycetemcomitans. An infection with A. actinomycetemcomitans appears to induce the production of citrullinated proteins, which are suspected of activating the immune system and driving the cascade of events leading to RA.. This is like putting together the last few pieces of a complicated jigsaw puzzle that has been worked on for many years, says ...
http://www.superdoctors.com/article/Researchers-Add-to-Evidence-That-Common-Bacterial-Cause-of-Gum-Disease-May-Drive-Rheumatoid-Arthritis/e9965e83-31d7-4646-899d-ac9348539b8b.html
IndexAuthor - E-Prints ComplutenseIndexAuthor - E-Prints Complutense
Herrera Gonzalez, David and Alonso Álvarez, Bettina and Arriba de la Fuente, Lorenzo de and Santa- Cruz Astorqui, Isabel and Serrano, Cristina and Sanz Alonso, Mariano (2014) Acute periodontal lesions. Periodontology 2000, 65 (1). pp. 149-177. ISSN 0906-6713 Mínguez, María and Pousa, Xiana and Herrera Gonzalez, David and Blasi, Andrea and Sánchez, Mari Carmen and León, Rubén and Sanz Alonso, Mariano (2014) Characterization and serotype distribution of Aggregatibacter actinomycetemcomitans isolated from a population of periodontitis patients in Spain. Archives of Oral Biology, 59 (12). pp. 1359-1367. ISSN 0003-9969 Alonso Álvarez, Bettina and Herrera Gonzalez, David and Sanz Alonso, Mariano and Iniesta Albentosa, Margarita and de Arriba de la Fuente, Lorenzo and Legido Arce, Berta and SantaCruz Astorqui, Isabel and Sánchez Pérez, Nerea and Mínguez Arnau, María (2014) Entrenamiento basado en un entorno interactivo para mejorar las competencias al final del grado. Proyecto de Innovación ...
https://eprints.ucm.es/view/people/Herrera_Gonzalez=3ADavid=3A=3A.html
Table 2Table 2
Immunological detection of antigens of Aggregatibacter actinomycetemcomitans, P intermedia, P gingivalisusing antibodies (ELISA ...
https://www.omicsonline.org/articles-images/2155-9929-6-232-t002.html
How RA Begins: A Detective Story - Vital JakeHow RA Begins: A Detective Story - Vital Jake
What causes rheumatoid arthritis?. The search, by scientists around the world, has been exhaustive, and the prey surprisingly elusive - but in breakthrough Johns Hopkins research, scientists Maximilian Konig, M.D., and Felipe Andrade, M.D., Ph.D., believe they have pinpointed one culprit: a kind of bacteria that lives in the mouth and is present in gum disease.. This form of bacteria has an unpronounceable name, Aggregatibacter actinomycetemcomitans, so the scientists who have discovered the terrible and important role it might play in RA just call it by its initials: Aa. We are very excited about it, says Konig. If their hypothesis is verified by other scientists and in larger studies, the possibilities of preventing RA from developing, and of treating early RA and possibly reversing symptoms, are enormous. This work was presented at the Plenary Session of the American College of Rheumatologys Annual Scientific Meeting in November 2016, and I recently wrote about it for Leap magazine, a ...
http://vitaljake.com/how-ra-begins-a-dectective-story/
Timken JP10049-JP10010-B Bearing, all the bearings you need here
Great news! Youre in the right place for Timken JP10049-JP10010-B bearing. By now you already know that, whatever you are looking for, youre sure to find it on AliExpress.
http://www.spiritueelrotterdam.nl/bearing-high-discount/58946-High-Quality-TimkenJP10049-JP10010-B-Bearing.htm
世界の市場調査レポート販売サイト：市場動向・分析・戦略レポート等
マーケットレポート.jp（MarketReport.jp）世界の市場調査レポートの総合販売サイトです。IT・通信産業、化学産業、エネルギー産業、自動車産業、医療産業、電子産業、食品産業など多様な産業の調査レポートを15万件以上取り扱っています。日本国内、アメリカ、中国、ヨーロッパなど地域レポートも販売しています。
https://data12.marketreport.jp/
recipe-blog.jp: レシピブログ - 料理ブログのレシピ満載！recipe-blog.jp: レシピブログ - 料理ブログのレシピ満載！
お料理ブログのレシピポータルサイト。みきママさん、山本ゆりさんなど人気ブロガーが多数活躍！73万件以上の料理レシピの中から、毎日のおかず、弁当、お菓子など簡単料理を検索。さらに人気順の並び替えが無料です！
http://siterankz.com/siteinfo/recipe-blog.jp
理論生物物理学ユニット （グレッグ・スティーブンズ） | OIST Groups理論生物物理学ユニット （グレッグ・スティーブンズ） | OIST Groups
理論生物物理学ユニット グレッグ・スティーブンズ 准教授（アジャンクト） greg.stephens at oist.jp 物理学者たちは長い間、物質およびエネルギーの本質を説明できる普遍的法則を探し求めてきましたが、最近まで複雑な生物系の研究は困難でした。理論生物物理ユニットでは、生体の脳および行動に関するシンプルで統一的な原理を探索しています。実験研究者と緊密に連携しながら、ユニットのメンバーは定量的な生物測定を、統計物理学、情報理論、およびダイナミカル（動的）システムから導かれる理論的概念と結び付けています。
https://groups.oist.jp/ja/bptu
Investigation of the structure of lipid A from Actinobacillus actinomycetemcomitans strain Y 4 and human clinical isolate PO...Investigation of the structure of lipid A from Actinobacillus actinomycetemcomitans strain Y 4 and human clinical isolate PO...
Investigation of the structure of lipid A from Actinobacillus actinomycetemcomitans strain Y 4 and human clinical isolate PO 1021-7
http://nparc.nrc-cnrc.gc.ca/eng/view/object/?id=1c888dba-8928-43ba-b56c-6c451b24c1ec
Oral Lactobacillus strains reduce cytotoxicity and cytokine release from peripheral blood mononuclear cells exposed to...Oral Lactobacillus strains reduce cytotoxicity and cytokine release from peripheral blood mononuclear cells exposed to...
This study evaluated the effect of oral lactobacilli on the cytotoxicity and cytokine release from peripheral blood mononuclear cells (PBMCs) when exposed to Aggregatibacter actinomycetemcomitans subtypes in vitro. The supernatants and cell wall extracts (CWEs) of eight A. actinomycetemcomitans strains, representing different subtypes, and three Lactobacillus strains were used. The PBMCs from six blood donors were exposed to supernatants and CWEs of A. actinomycetemcomitans or Lactobacillus strains alone or combinations and untreated cells as control. The cytotoxicity was determined by trypan blue exclusion method and IL-1β secretion by ELISA. TNF-α, IL-6, and IL-8 secretions were measured using Bioplex Multiplex Immunoassay. Supernatants or CWEs from all bacterial strains showed cytotoxicity and IL-1β secretion and the subtypes of A. actinomycetemcomitans showed generally a significantly higher effect on PBMCs than that of the Lactobacillus strains. Two highly toxic A. actinomycetemcomitans strains
https://bmcmicrobiol.biomedcentral.com/articles/10.1186/s12866-020-01959-5/figures/4
Microbiologics: 01175K Aggregatibacter actinomycetemcomitans (b) derived from ATCC® 29522™* KWIK-STIK
The ATCC Licensed Derivative Emblem, the ATCC Licensed Derivative word mark and the ATCC catalog marks are trademarks of ATCC. Microbiologics, Inc. is licensed to use these trademarks and to sell products derived from ATCC® cultures. Look for the ATCC Licensed Derivative © Emblem for products derived from ATCC© cultures. ...
https://www.microbiologics.com/01175K
Bdellovibrio bacteriovorus attacks Aggregatibacter actinomycetemcomitans
Sockett and Lambert, 2004. Balos are ubiquitous in nature and have been isolated from diverse terrestrial and aquatic habitats, from biofilms as well as from animal feces
http://dentisty.org/bdellovibrio-bacteriovorus-attacks-aggregatibacter-actinomycet.html
Isolation and characterization of the dnaKJ operon from Actinobacillus actinomycetemcomitans - Fingerprint - Kyushu...
Fingerprint Dive into the research topics of Isolation and characterization of the dnaKJ operon from Actinobacillus actinomycetemcomitans. Together they form a unique fingerprint. ...
https://kyushu-u.pure.elsevier.com/en/publications/isolation-and-characterization-of-the-dnakj-operon-from-actinobac/fingerprints/
497e) Design of a Cholesterol-Binding Peptide to Inhibit Bacterial Toxin Activity | AIChE497e) Design of a Cholesterol-Binding Peptide to Inhibit Bacterial Toxin Activity | AIChE
Pathogenic bacteria produce numerous virulence factors, including protein toxins, to enhance their growth and survival within the host. Our lab seeks to understand the mechanisms of bacterial toxin delivery to identify and exploit therapeutic targets. In this project, we have focused on a member of the repeats-in-toxin (RTX) family of proteins, which are secreted by many Gram negative bacteria, including Bordetella pertussis, Escherichia coli, and Aggregatibacter actinomycetemcomitans. The leukotoxin (LtxA) secreted by A. actinomycetemcomitans specifically kills human white blood cells to disrupt the host immune response and therefore plays a key role in bacterial colonization of the host. The cell type specificity of LtxA arises from its reported targeting of the lymphocyte function-associated antigen-1 (LFA-1) integrin, which is only expressed by human white blood cells. In addition, we recently showed that LtxA binds with a strong affinity to cholesterol, and inhibition of this binding to ...
https://www.aiche.org/conferences/aiche-annual-meeting/2018/proceeding/paper/497e-design-cholesterol-binding-peptide-inhibit-bacterial-toxin-activity
Bacterial heat shock protein GroEL (Hsp64) exerts immunoregulatory effects on T cells by utilizing apoptosisBacterial heat shock protein GroEL (Hsp64) exerts immunoregulatory effects on T cells by utilizing apoptosis
Aggregatibacter actinomycetemcomitans (Aa) expresses a 64-kDa GroEL protein belonging to the heat shock family of proteins. This protein has been shown to influence human host cells, but the apoptotic capacity of the GroEL protein regarding T cells is not yet known. The purpose of this study was to investigate the ability of A. actinomycetemcomitans GroEL (AaGroEL) protein to induce human peripheral blood T-cell apoptosis. Endogenous, purified AaGroEL protein was used as an antigen. In AaGroEL-treated T cells, the data indicated that phosphatidylserine exposure, an early apoptotic event, was dose- and time-dependent. The AaGroEL-treated T cells were also positive for active caspase-3 in a dose-dependent manner. The rate of AaGroEL-induced apoptosis was suppressed by the addition of the general caspase inhibitor Z-VAD-FMK. Furthermore, cleaved caspase-8 bands (40/36 kDa and 23 kDa) were identified in cells responding to AaGroEL. DNA fragmentation was also detected in the AaGroEL-treated T cells. ...
https://openaccess.iyte.edu.tr/handle/11147/6028
Quintessence PublishingQuintessence Publishing
We have observed that autoantibodies reactive with important phospholipid antigens are present in the sera and gingival crevicular fluids of patients with periodontitis. The antibodies are likely induced by commonly occuring plaque bacteria. Phosphorylcholine (PC) is a prevalent antigen found on 30-40% of plaque bacteria, and patients with periodontal attachment loss have significantly higher concentrations of IgG anti-PC than do individuals without attachment loss. Data indicate that these antibodies bind to and opsonize oral microorganisms such as Actinobacillus actinomycetemcomitans (A. actinomycetemcomitans) and further that they react with and opsonize modified low-density lipoproteins (LDL). Anti-β2-glycoprotein 1-dependent anti-cardiolipin (anti-CL), another antibody of interest, is found at elevated levels in 15-20% of patients with generalized periodontitis. In patients with systemic lupus erythemathosis (SLE) or the antiphospholipid syndrome (APS) elevated levels of these antibodies ...
http://www.quintpub.com/journals/obm/archive_display_abstract.php3?journalArt=7473
Short-Term Effects Of Systemic Antibiotics During Periodontal HealingShort-Term Effects Of Systemic Antibiotics During Periodontal Healing
Objectives: To investigate the short-term effects of nonsurgical therapy (scaling and root planing, SRP) on the subgingival microbiota in chronic (CP) and aggressive (AP) perio dontal disease. Method and Materials: Ninety-seven CP and AP subjects underwent full-mouth SRP on 2 consecutive days. AP patients were randomly assigned to either receive systemic metronidazole plus amoxicillin (AP+AB) or were treated mechanically alone (AP). Pathogens were identified with 16S rRNA oligodeoxynucleotide probes and dot-blot hybridization before and at days 2, 3, 4, 7, 10, and 21 of healing. CP subjects were treated by scaling and root planing along with placebo tablets. Results: Initially, AP cell counts were 69.9- (Porphyromonas gingivalis), 10.2- (Aggregatibacter actinomycetemcomitans), 5.7- (Tannerella forsythia), and 3.3-fold (Prevotella intermedia) enhanced compared to CP cell counts. Following SRP, immediate elimination occurred in single individuals of all three treatment groups at day 2. After SRP ...
http://www.quintpub.com/journals/qi/abstract.php?iss2_id=663&article_id=7978&article=6&title=Short-Term%20Effects%20Of%20Systemic%20Antibiotics%20During%20Periodontal%20Healing
EC 1.1.1.266EC 1.1.1.266
Accepted name: dTDP-4-dehydro-6-deoxyglucose reductase. Reaction: dTDP-α-D-fucopyranose + NAD(P)+ = dTDP-4-dehydro-6-deoxy-α-D-glucose + NAD(P)H + H+. For diagram of reaction click here.. Glossary: dTDP-4-dehydro-6-deoxy-α-D-glucose = dTDP-6-deoxy-α-D-xylo-hexopyranos-4-ulose = thymidine 5-[3-(6-deoxy-D-xylo-hexopyranosyl-4-ulose) diphosphate]. Other name(s): dTDP-4-keto-6-deoxyglucose reductase; dTDP-D-fucose:NADP+ oxidoreductase; Fcf1; dTDP-6-deoxy-D-xylo-hex-4-ulopyranose reductase. Systematic name: dTDP-α-D-fucopyranose:NAD(P)+ oxidoreductase. Comments: The enzymes from the Gram-negative bacteria Aggregatibacter actinomycetemcomitans and Escherichia coli O52 are involved in activation of fucose for incorporation into capsular polysaccharide O-antigens [1,3]. The enzyme from the Gram-positive bacterium Geobacillus tepidamans is involved in activation of fucose for incorporation into the organisms S-layer [2].The enzyme from Escherichia coli O52 has a higher catalytic efficiency with ...
http://www.sbcs.qmul.ac.uk/iubmb/enzyme/EC1/1/1/266.html
J. Appl. Oral Sci. - vol.14 issue3J. Appl. Oral Sci. - vol.14 issue3
Occurrence of Actinobacillus actinomycetemcomitans in patients with chronic periodontitis, aggressive periodontitis, healthy subjects and children with gingivitis in two cities of the state of São Paulo, Brazil ...
http://www.scielo.br/scielo.php?script=sci_issuetoc&pid=1678-775720060003&lng=en&nrm=iso
Elevated oral pathogens, less bacterial diversity linked to risk of developing precancerous gastric lesions - Medicalnewser.comElevated oral pathogens, less bacterial diversity linked to risk of developing precancerous gastric lesions - Medicalnewser.com
The researchers performed full-mouth examinations to assess participants periodontal conditions. Saliva and dental plaque samples were collected to evaluate colonization by several of pathogens - P. gingivalis, T. denticola, T. forsythia, and A. actinomycetemcomitans - and to characterize oral microbial diversity.. Compared with the control group, patients with precancerous lesions experienced higher prevalence of bleeding when probed (31.5 percent versus 22.4 percent), higher levels of two pathogens (T. denticola and A. actinomycetemcomitans), and less bacterial diversity in their saliva.. A further analysis, which took into account sociodemographic factors, oral health behaviors, and periodontal assessments, revealed additional predictors of precancerous lesions: elevated colonization of three pathogens (T. forsythia, T. denticola, and A. actinomycetemcomitans), decreased bacterial diversity in dental plaque, and not flossing regularly.. The researchers concluded that the colonization of ...
https://www.medicalnewser.com/2017/11/29/elevated-oral-pathogens-less-bacterial-diversity-linked-to-risk-of-developing-precancerous-gastric-lesions.html
Population-Based Study of Salivary Carriage of Periodontal Pathogens in Adults | Journal of Clinical MicrobiologyPopulation-Based Study of Salivary Carriage of Periodontal Pathogens in Adults | Journal of Clinical Microbiology
The present large-scale, general population-based data suggest that distinct species have a different carriage profile, depending on variables such as age group, educational level, smoking history, and periodontal status. In general, the carriage of periodontal pathogens proved to be common, and only 12% of the 1,294 subjects were free of all six target bacteria examined. More than half of the population had T. forsythensis, one-third T. denticola, P. gingivalis or C. rectus, and one-fifth P. intermedia or A. actinomycetemcomitans. Logistic regression models revealed different variables to be associated with distinct species in dentate subjects.. Periodontitis-associated organisms colonize not only subgingival sites, but also supragingival sites (20, 35), and appear in saliva (5, 7, 8, 15, 30, 32). Stimulation by masticating a piece of paraffin looses still-attached microorganisms or clumps of microorganisms from oral biofilms into salivary sediment. According to Umeda et al. (30), whole saliva ...
https://jcm.asm.org/content/45/8/2446
Details - Cryptographic Algorithm Validation Program | CSRCDetails - Cryptographic Algorithm Validation Program | CSRC
IDCore 30 rev B is a highly secured smartcard platform compliant with Javacard 2.2.2, Global Platform 2.1.1 & 2.2 Amendment D standards, designed to operate with Infineon SLE78 chip family. The library implements TDEA, AES, AES-CMAC, SHA1-224-256-384-512, RSA, RSA CRT, ECDSA, ECC CDH, SP800-108 KDF and SP800-90A DRBG ...
https://csrc.nist.gov/Projects/Cryptographic-Algorithm-Validation-Program/details?source=KDF&number=81
Differentiation of oral bacteria in in vitro cultures and human saliva by secondary electrospray ionization - mass spectrometry...Differentiation of oral bacteria in in vitro cultures and human saliva by secondary electrospray ionization - mass spectrometry...
The detection of bacterial-specific volatile metabolites may be a valuable tool to predict infection. Here we applied a real-time mass spectrometric technique to investigate differences in volatile metabolic profiles of oral bacteria that cause periodontitis. We coupled a secondary electrospray ionization (SESI) source to a commercial high-resolution mass spectrometer to interrogate the headspace from bacterial cultures and human saliva. We identified 120 potential markers characteristic for periodontal pathogens Aggregatibacter actinomycetemcomitans (n = 13), Porphyromonas gingivalis (n = 70), Tanerella forsythia (n = 30) and Treponema denticola (n = 7) in in vitro cultures. In a second proof-of-principle phase, we found 18 (P. gingivalis, T. forsythia and T. denticola) of the 120 in vitro compounds in the saliva from a periodontitis patient with confirmed infection with P. gingivalis, T. forsythia and T. denticola with enhanced ion intensity compared to two healthy controls. In conclusion, ...
http://www.zora.uzh.ch/id/eprint/113700/
THE EFFECT OF CURCUMA XANTHORRHIZA ETHANOL EXTRACT ON THE VIABILITY OF STREPTOCOCCUS MUTANS AND AGGREGATIBACTER...THE EFFECT OF CURCUMA XANTHORRHIZA ETHANOL EXTRACT ON THE VIABILITY OF STREPTOCOCCUS MUTANS AND AGGREGATIBACTER...
THE EFFECT OF CURCUMA XANTHORRHIZA ETHANOL EXTRACT ON THE VIABILITY OF STREPTOCOCCUS MUTANS AND AGGREGATIBACTER ACTINOMYCETEMCOMITANS (DENTAL BIOFILM RESEARCH: IN VITRO STUDY)
https://innovareacademics.in/journals/index.php/ajpcr/article/view/23087
Cells | Free Full-Text | Inflammatory and Bone Remodeling Responses to the Cytolethal Distending Toxins | HTMLCells | Free Full-Text | Inflammatory and Bone Remodeling Responses to the Cytolethal Distending Toxins | HTML
The cytolethal distending toxins (CDTs) are a family of exotoxins produced by a wide range of Gram-negative bacteria. They are known for causing genotoxic stress to the cell, resulting in growth arrest and eventually apoptotic cell death. Nevertheless, there is evidence that CDTs can also perturb the innate immune responses, by regulating inflammatory cytokine production and molecular mediators of bone remodeling in various cell types. These cellular and molecular events may in turn have an effect in enhancing local inflammation in diseases where CDT-producing bacteria are involved, such as Aggregatibacter actinomycetemcomitans, Haemophilus ducreyi, Campylobacter jejuni and Helicobacter hepaticus. One special example is the induction of pathological bone destruction in periodontitis. The opportunistic oral pathogen Aggregatibatcer actinoycemetemcomitans, which is involved in the aggressive form of the disease, can regulate the molecular mechanisms of bone remodeling in a manner that favors bone
http://www.mdpi.com/2073-4409/3/2/236/htm
Bacterial Genome Sequencing - SeqMaticBacterial Genome Sequencing - SeqMatic
Obradović, Davor, et al. A Cytolethal Distending Toxin Variant from Aggregatibacter actinomycetemcomitans with an Aberrant CdtB That Lacks the Conserved Catalytic Histidine 160. PloS one 11.7 (2016): e0159231.. Hemp, James, et al. Draft Genome Sequence of Ornatilinea apprima P3M-1, an Anaerobic Member of the Chloroflexi Class Anaerolineae. Genome Announcements 3.6 (2015): e01353-15.. Ward, Lewis M., et al. Draft Genome Sequence of Leptolinea tardivitalis YMTK-2, a Mesophilic Anaerobe from the Chloroflexi Class Anaerolineae. Genome Announcements 3.6 (2015): e01356-15.. Hemp, James, et al. Draft Genome Sequence of Levilinea saccharolytica KIBI-1, a Member of the Chloroflexi Class Anaerolineae. Genome Announcements 3.6 (2015): e01357-15.. Hemp, James, et al. Draft Genome Sequence of Ardenticatena maritima 110S, a Thermophilic Nitrate-and Iron-Reducing Member of the Chloroflexi Class Ardenticatenia. Genome Announcements 3.6 (2015): e01347-15.. Pace, Laura A., et al. Draft Genome of ...
http://www.seqmatic.com/services/dna-sequencing/bacterial-genome-sequencing/
The International Journal of Oral & Maxillofacial ImplantsThe International Journal of Oral & Maxillofacial Implants
Materials and Methods: The present study was designed as a prospective stratified randomized controlled clinical trial. Patients were scheduled to receive two implants with different types of abutments in the posterior mandible. Three months after implant placement, titanium and zirconium abutments were connected. Five weeks after abutment connections, the abutments were removed, probing depth measurements were recorded, and gingival biopsy samples were obtained. Abutments and biopsy specimens were analyzed by reverse-transcriptase polymerase chain reaction to compare the DNA copy numbers of Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, and total bacteria. The surface free energy of the abutments was calculated by sesile water drop before replacement ...
https://jomi.quintessenz.de/index.php?doc=abstract&abstractID=21641
Department of Dentistry and Oral Health - Section for Pediatric Dentistry - Researchers - Research - Aarhus UniversityDepartment of Dentistry and Oral Health - Section for Pediatric Dentistry - Researchers - Research - Aarhus University
Teeth/gums (dental generel anaesthsia, mineralization disturbances), Infection (Actinobacillus actinomycetemcomitans, oral pathogens, population genetics of bacteria, virulence factors), Infection (antibiotics), Molecular medicine, Odontology, Teeth/gums (deveopmental disturbances of dental hard tissues, mineralization disturbances). ...
https://pure.au.dk/portal/en/organisations/institut-for-odontologi-og-oral-sundhed--sektion-for-paedodonti
Click to printClick to print
Periodontal Disease or Gum Disease is a common condition affecting about 47% of the population and has been present for millennia. Early humans also suffered from this debilitating condition.. There are usually no symptoms like pain despite the fact that the bone and ligaments holding teeth are slowly melting or literally rotting away as part of inflammation.. There are a few known disease causing bacteria that are present in all mouths such as P gingivalis, P Intermedia, and A actinomycetemcomitans. They are responsible for causing Periodontitis in susceptible individuals. Susceptibility to Periodontal Disease is largely genetically determined. In other words, if your parents, grandparents or the family in the ancestral line had Periodontal Disease, you are more likely to get the disease. There are also modifying conditions including habits, emotional stress, medications and diseases which affect Periodontal disease, for example, diet, oral hygiene, smoking, medications such as steroids or ...
https://www.1300smiles.com.au/periodontal-disease/
DIY Research » JP200C真空管前級近期推出！
開站以來我們陸續推出了MP150和JC-3兩款後級擴大機，始終少了一個前級套件來搭配，在幾個月的時間中我們開發試裝了幾套前級，最終決定先推出JP200C真空管前級做為diyResearch的第一款前級套件。. 選擇JP200C為第一款前級的主要幾個原因，第一：以Jadis JP200架構基礎的JP200C擁有很迷人的聲音特質。第二：我們對於這個電路很熟悉，這幾年來前前後後裝了許多各種不同版本的JP200，累積了豐富的調教經驗。第三：經過長時間的調整試聽之後，此版本的JP200C非常穩定，同時訊噪比優良。以下先貼出幾張量產PCB的裝機完成品照片供大家瞧瞧。. ...
http://www.diyresearch.net/?p=19
Aggregatibacter actinomycetemcomitansAggregatibacter actinomycetemcomitans
nov., Aggregatibacter aphrophilus comb. nov. and Aggregatibacter segnis comb. nov., and emended description of Aggregatibacter ... Aggregatibacter actinomycetemcomitans is a Gram-negative, facultative anaerobe, nonmotile bacterium that is often found in ... Type strain of Aggregatibacter actinomycetemcomitans at BacDive - the Bacterial Diversity Metadatabase (Articles with short ... Haubek D (September 2010). "The highly leukotoxic JP2 clone of Aggregatibacter actinomycetemcomitans: evolutionary aspects, ...
https://en.wikipedia.org/wiki/Aggregatibacter_actinomycetemcomitans
Index of oral health and dental articlesIndex of oral health and dental articles
Aggregatibacter actinomycetemcomitans • Aim toothpaste • Akers' clasp • Alberta Dental Association and College • Alfred Fones ...
https://en.wikipedia.org/wiki/Index_of_oral_health_and_dental_articles
CapnophileCapnophile
found in the mouth (e.g. Aggregatibacter actinomycetemcomitans). These are a cause of aggressive juvenile periodontitis. ... Bhattacharjee, MK; Childs (June 2011). "Sensitivity of the periodontal pathogen Aggregatibacter actinomycetemcomitans at mildly ... Other capnophilic pathogens occur in the gram-negative Aggregatibacter spp. ...
https://en.wikipedia.org/wiki/Capnophile
EpoxygenaseEpoxygenase
Aggregatibacter actinomycetemcomitans and E. coli. That is, they are toxic to leukocytes as well as many other cell types and ...
https://en.wikipedia.org/wiki/Epoxygenase
Dental plaqueDental plaque
Aggregatibacter actinomycetemcomitans Prevotella intermedia Eubacterium spp. Treponema spp. Porphyromonas gingivalis ...
https://en.wikipedia.org/wiki/Dental_plaque
List of long species namesList of long species names
Aggregatibacter actinomycetemcomitans (Klinger, 1912) Nørskov-Lauritsen and Kilian, 2006 - family Pasteurellaceae. A Gram- ... nov., Aggregatibacter aphrophilus comb. nov. and Aggregatibacter segnis comb. nov., and emended description of Aggregatibacter ... Henderson B, Ward JM, Ready D (October 2010). "Aggregatibacter (Actinobacillus) actinomycetemcomitans: a triple A* ... Haemophilus paraphrophilus and Haemophilus segnis as Aggregatibacter actinomycetemcomitans gen. nov., comb. ...
https://en.wikipedia.org/wiki/List_of_long_species_names
Aggressive periodontitisAggressive periodontitis
Various studies have associated Aggregatibacter actinomycetemcomitans, formerly known as Actinobacillus actinomycetemcomitans, ... As well as Aggregatibacter actinomycetemcomitans being associated with this, the synergism of the disease also accounts for ... High levels of Aggregatibacter (or Actinobacillus) actinomycetemcomitans and, in some populations, Porphyromonas gingivalis. ... This is due to the suppression of serum IgG2 and antibody against Aggregatibacter actinomycetemcomitans found in smokers. ...
https://en.wikipedia.org/wiki/Aggressive_periodontitis
Parish SedghizadehParish Sedghizadeh
The in vivo Th17 and Treg immune response to Aggregatibacter actinomycetemcomitans. Mol Oral Microbiol 2017;32:490-99. Junka A ... "The in vivo Th17 and Treg immune responses to Aggregatibacter actinomycetemcomitans". Sedghizadeh, Parish P.; Chen, Meng-Tse; ...
https://en.wikipedia.org/wiki/Parish_Sedghizadeh
CoccobacillusCoccobacillus
Aggregatibacter actinomycetemcomitans is a Gram-negative coccobacillus prevalent in subgingival plaques. Acinetobacter strains ...
https://en.wikipedia.org/wiki/Coccobacillus
ActinomycesActinomyces
Aggregatibacter actinomycetemcomitans has been identified as being of note in periodontal disease. The genus is typically the ... The genus Actinomyces comprises the following species: "A. actinomycetemcomitans" Iinuma et al. 1994 "A. bouchesdurhonensis" ...
https://en.wikipedia.org/wiki/Actinomyces
Aggregatibacter iron-regulated sRNAAggregatibacter iron-regulated sRNA
JA01 is conserved only among A. actinomycetemcomitans. JA02 is present in both A. actinomycetemcomitans and P. multocida. JA 03 ... sequence were identified by bioinformatics analysis in Aggregatibacter actinomycetemcomitans HK1651 called JA01-JA04. The ... "Novel iron-regulated and Fur-regulated small regulatory RNAs in Aggregatibacter actinomycetemcomitans". Molecular Oral ...
https://en.wikipedia.org/wiki/Aggregatibacter_iron-regulated_sRNA
Bacterial cellular morphologiesBacterial cellular morphologies
Aggregatibacter actinomycetemcomitans is a gram negative coccobacillus which is prevalent in subgingival plaques. Acinetobacter ...
https://en.wikipedia.org/wiki/Bacterial_cellular_morphologies
AggregatibacterAggregatibacter
Haemophilus paraphrophilus and Haemophilus segnis as Aggregatibacter actinomycetemcomitans gen. Nov., comb. Nov., ... Aggregatibacter aphrophilus comb. Nov. And Aggregatibacter segnis comb. Nov., and emended description of Aggregatibacter ... Aggregatibacter is a genus in the phylum Pseudomonadota (Bacteria), which contains three species, namely: A. ... actinomycetemcomitans (Klinger 1912) Nørskov-Lauritsen and Kilian 2006, (type species of the genus); (from Greek noun aktis, ...
https://en.wikipedia.org/wiki/Aggregatibacter
Aggregatibacter segnisAggregatibacter segnis
Haemophilus paraphrophilus and Haemophilus segnis as Aggregatibacter actinomycetemcomitans gen. nov., comb. nov., ... Aggregatibacter aphrophilus comb. nov. and Aggregatibacter segnis comb. nov., and emended description of Aggregatibacter ... Aggregatibacter segnis is a species of bacteria. A. segnis can be cultured on chocolate agar. Norskov-Lauritsen N, Kilian M. ( ... and clinical significance of Haemophilus and Aggregatibacter species with host specificity for humans". Clinical Microbiology ...
https://en.wikipedia.org/wiki/Aggregatibacter_segnis
Aggregatibacter aphrophilusAggregatibacter aphrophilus
Haemophilus paraphrophilus and Haemophilus segnis as Aggregatibacter actinomycetemcomitans gen. nov., comb. nov., ... Aggregatibacter aphrophilus comb. nov. and Aggregatibacter segnis comb. nov., and emended description of Aggregatibacter ... Aggregatibacter aphrophilus is a species of bacteria. It is one of the HACEK organisms. Norskov-Lauritsen N, Kilian M. (2006 ... "Aggregatibacter aphrophilus". List of Prokaryotic names with Standing in Nomenclature (LPSN). Retrieved March 21, 2022. "HACEK ...
https://en.wikipedia.org/wiki/Aggregatibacter_aphrophilus
ActinobacillusActinobacillus
Haemophilus paraphrophilus and Haemophilus segnis as Aggregatibacter actinomycetemcomitans gen. nov., comb. nov., ... Aggregatibacter aphrophilus comb. nov. and Aggregatibacter segnis comb. nov., and emended description of Aggregatibacter ... A. actinomycetemcomitans occurs in the human oral microflora, and together with anaerobic or capnophilic organisms (HACEK group ... An analysis of A. actinomycetemcomitans indicated it was monophyletic with Haemophilus aphrophilus and H. segnis, and they were ...
https://en.wikipedia.org/wiki/Actinobacillus
DNA adenine methylaseDNA adenine methylase
The retainment of viability despite a dam gene knockout is also seen in Salmonella and Aggregatibacter actinomycetemcomitans. ... A knockout of the dam gene in Aggregatibacter actinomycetemcomitans resulted in dysregulated levels of the protein, leukotoxin ... "Inactivation of DNA adenine methyltransferase alters virulence factors in Actinobacillus actinomycetemcomitans". Oral ...
https://en.wikipedia.org/wiki/DNA_adenine_methylase
Periodontal diseasePeriodontal disease
Research in 2004 indicated three gram negative anaerobic species: Aggregatibacter actinomycetemcomitans, Porphyromonas ...
https://en.wikipedia.org/wiki/Periodontal_disease
Jørgen SlotsJørgen Slots
Slots is responsible for discovering the role of Aggregatibacter actinomycetemcomitans (previously Actinobacillus ... "Comparison of Two Selective Media for Actinobacillus actinomycetemcomitans." J Clin Microbiol 1986;24:636-638. Fryman A, ... actinomycetemcomitans) in aggressive periodontitis, previously known as juvenile periodontitis. In 1982, Slots developed ...
https://en.wikipedia.org/wiki/Jørgen_Slots
Dispersin BDispersin B
... is produced by Aggregatibacter actinomycetemcomitans, a Gram-negative oral bacterium, when it needs to detach and ... Aggregatibacter actinomycetemcomitans. The bacteria secrete Dispersin B to release adherent cells from a mature biofilm colony ... A. actinomycetemcomitans forms asymmetric biofilm lobed colonies that release single cells or small clusters of bacterial cells ... Kaplan JB, Ragunath C, Ramasubbu N, Fine DH (August 2003). "Detachment of Actinobacillus actinomycetemcomitans biofilm cells by ...
https://en.wikipedia.org/wiki/Dispersin_B
Tryptic soy-serum-bacitracin-vancomycinTryptic soy-serum-bacitracin-vancomycin
... a type of agar plate medium used in microbiological testing to select for Aggregatibacter actinomycetemcomitans (A.a.). It was ... "Comparison of Two Selective Media for Actinobacillus actinomycetemcomitans." J Clin Microbiol 1986;24:636-638. Slots, J. " ... "Selective medium for isolation of Actinobacillus actinomycetemcomitans." J Clin Microbiol 1982;15:606-609. (Microbiology). ...
https://en.wikipedia.org/wiki/Tryptic_soy-serum-bacitracin-vancomycin
HACEK organismsHACEK organisms
Haemophilus parahaemolyticus Haemophilus parainfluenzae Aggregatibacter Aggregatibacter actinomycetemcomitans (previously ... Actinobacillus actinomycetemcomitans) Aggregatibacter aphrophilus (previously Haemophilus aphrophilus) Aggregatibacter ... However, taxonomic rearrangements have changed the A to Aggregatibacter species and the H to Haemophilus species to reflect the ... HACEK is an abbreviation of the initials of the genera of this group of bacteria: Haemophilus, Aggregatibacter (previously ...
https://en.wikipedia.org/wiki/HACEK_organisms
List of bacterial vaginosis microbiotaList of bacterial vaginosis microbiota
Actinobacteria spp Anaerococcus spp Actinomyces naeslundii Aggregatibacter actinomycetemcomitans Atopobium vaginae Bacteroides ...
https://en.wikipedia.org/wiki/List_of_bacterial_vaginosis_microbiota
MaresinMaresin
Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans; the latter functional defects were improved by treating the ...
https://en.wikipedia.org/wiki/Maresin
Cytolethal distending toxinCytolethal distending toxin
Medically important CDT producers include: Haemophilus ducreyi (chancroids) Aggregatibacter actinomycetemcomitans ( ...
https://en.wikipedia.org/wiki/Cytolethal_distending_toxin
DTDP-6-deoxy-L-talose 4-dehydrogenase (NAD+)DTDP-6-deoxy-L-talose 4-dehydrogenase (NAD+)
H+ The enzyme from bacterium Aggregatibacter actinomycetemcomitans participates in the biosynthesis of the serotype c-specific ... diphosphate-6-deoxy-L-lyxo-4-hexulose reductase synthesizing dTDP-6-deoxy-L-talose from Actinobacillus actinomycetemcomitans". ...
https://en.wikipedia.org/wiki/DTDP-6-deoxy-L-talose_4-dehydrogenase_(NAD )
Periodontal pathogenPeriodontal pathogen
Aggregatibacter actinomycetemcomitans Porphyromonas gingivalis Tannerella forsythia (formerly Bacteroides forsythus) Treponema ...
https://en.wikipedia.org/wiki/Periodontal_pathogen
2014 Ju-Jitsu World Championships2014 Ju-Jitsu World Championships
The 2014 Ju-Jitsu World Championship were the 12th edition of the Ju-Jitsu World Championships, and were held in Paris, France from November 28 to November 30, 2014. 28.11.2014 - Men's and Women's Fighting System, Men's and Women's Jiu-Jitsu (ne-waza), Men's Duo System - Classic 29.11.2014 - Men's and Women's Fighting System, Men's and Women's Jiu-Jitsu (ne-waza), Women's Duo System - Classic 30.11.2014 - Men's Jiu-Jitsu (ne-waza), Mixed Duo System - Classic, Team event Vincent MATCZAK (2014-09-30). "4TH INVITAION TO WORLD CHAMPIONSHIP 2014" (PDF). Retrieved 2019-11-28.[dead link] Online results Official results (PDF) Mixed team event results (PDF) (All articles with dead external links, Articles with dead external links from April 2022, Ju-Jitsu World Championships, 2014 in French sport ...
https://en.wikipedia.org/wiki/2014_Ju-Jitsu_World_Championships
Bolley JohnsonBolley Johnson
Bolley L. "Bo" Johnson (born November 15, 1951) is an American politician from the state of Florida. A member of the Democratic Party, Johnson was a member of the Florida House of Representatives, and served as the Speaker of the Florida House of Representatives. Johnson is from Milton, Florida. His father and grandfather served as county commissioners for Santa Rosa County, Florida. Johnson graduated from Milton High School, and became the first member of his family to attend college. He received his bachelor's degree from Florida State University. Johnson volunteered for Mallory Horne when Horne served as the president of the Florida Senate. At the age of 22, Johnson met Lawton Chiles, then a member of the United States Senate, who hired him as a legislative aide in 1973. Johnson was elected to the Florida House of Representatives, representing the 4th district from November 7, 1978 to November 3, 1992. He also served the 1st district from November 3, 1992 to November 8, 1994. He became the ...
https://en.wikipedia.org/wiki/Bolley_Johnson
Dont Say NoDon't Say No
... may refer to: Don't Say No (Billy Squier album), a 1981 album by American rock singer Billy Squier, and its title track Don't Say No (Seohyun EP), a 2016 extended play by South Korean pop singer Seohyun, and its title track "Don't Say No" (Tom Tom Club song), from the 1988 album Boom Boom Chi Boom Boom "Don't Say No", by Robbie Williams from the 2005 album Intensive Care "Don't Say No Tonight", a 1985 single by Eugene Wilde This disambiguation page lists articles associated with the title Don't Say No. If an internal link led you here, you may wish to change the link to point directly to the intended article. (Disambiguation pages with short descriptions, Short description is different from Wikidata, All article disambiguation pages, All disambiguation pages, Disambiguation pages ...
https://en.wikipedia.org/wiki/Don't_Say_No
Aggregatibacter actinomycetemcomitans (Klinger 1912) Nørskov-Lauritsen and Kilian 2006 - 43717 | ATCCAggregatibacter actinomycetemcomitans (Klinger 1912) Nørskov-Lauritsen and Kilian 2006 - 43717 | ATCC
nov., Aggregatibacter aphrophilus comb. nov. and Aggregatibacter segnis comb. nov., and emended description of Aggregatibacter ... Aggregatibacter actinomycetemcomitans (Klinger 1912) Nørskov-Lauritsen and Kilian 2006 43717™ Download Genome Learn about our ... The certificate of analysis for that lot of Aggregatibacter actinomycetemcomitans (Klinger 1912) Nørskov-Lauritsen and Kilian ... The certificate of origin for that lot of Aggregatibacter actinomycetemcomitans (Klinger 1912) Nørskov-Lauritsen and Kilian ...
https://www.atcc.org/products/43717
Isotype: MIgG3, MIgM, Positive Tested Species Reactivity: Aggregatibacter-actinomycetemcomitans-serotype-d, EpicoccumIsotype: MIgG3, MIgM, Positive Tested Species Reactivity: Aggregatibacter-actinomycetemcomitans-serotype-d, Epicoccum
To provide a better shopping experience, our website uses cookies. Continuing use of the site implies consent ...
https://dshb.biology.uiowa.edu/custitem16/MIgG3,MIgM/custitem34/Aggregatibacter-actinomycetemcomitans-serotype-d,Epicoccum
Species: Aggregatibacter actinomycetemcomitansSpecies: Aggregatibacter actinomycetemcomitans
nov., Aggregatibacter aphrophilus comb. nov. and Aggregatibacter segnis comb. nov., and emended description of Aggregatibacter ... nov., Aggregatibacter aphrophilus comb. nov. and Aggregatibacter segnis comb. nov., and emended description of Aggregatibacter ... nov., Aggregatibacter aphrophilus comb. nov. and Aggregatibacter segnis comb. nov., and emended description of Aggregatibacter ... Aggregatibacter Actinomycetemcomitans: Clinical Significance of a Pathobiont Subjected to Ample Changes in Classification and ...
https://lpsn.dsmz.de/species/aggregatibacter-actinomycetemcomitans
Aggregatibacter actinomycetemcomitans | CCUG 46863 | BacDiveID:152464
Aggregatibacter actinomycetemcomitans. Full Scientific Name (PNU). Aggregatibacter actinomycetemcomitans (Klinger 1912) Nørskov ... Other strains from Aggregatibacter actinomycetemcomitans. A. actinomycetemcomitans DSM 8324, ATCC 33384, CCUG 13227, ... (type ... A. actinomycetemcomitans CCUG 61155 A. actinomycetemcomitans JCM 30399 A. actinomycetemcomitans JCM 8577, ATCC 43719 A. ... A. actinomycetemcomitans CIP 102906 A. actinomycetemcomitans CIP 63.30 A. actinomycetemcomitans CIP 52.108 A. ...
https://bacdive.dsmz.de/strain/152464
Prevalence of Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis and Prevotella intermedia on different population...Prevalence of Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis and Prevotella intermedia on different population...
Prevalence; Aggregatibacter actinomycetemcomitans; Porphyromonas gingivalis; Prevotella intermedia; Age groups. · Portugués · ... FERNANDES, Camila Borges et al. Prevalence of Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis and Prevotella ... Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Prevotella intermedia, on different groups, with and without ... We observed that the newborns allocated A. actinomycetemcomitans alone (2.56%). On children with 6-13 years old population we ...
http://revodonto.bvsalud.org/scielo.php?script=sci_abstract&pid=S1806-146X2010000400004&lng=es&nrm=iso&tlng=en
Effect of Cigarette Smoking on Subgingival BacteriaEffect of Cigarette Smoking on Subgingival Bacteria
Aggregatibacter actinomycetemcomitans 0.57 (0.2-2.1). 0.40. 0.76 (0.1-4.1). 0.74. Campylobacter rectus 2.67 (0.5-13.9). 0.25. ...
https://www.medscape.com/viewarticle/878955_4
Antimicrobial effect against |i|Aggregatibacter actinomycetemcomitans|/i| of advanced and injectable platelet-rich fibrin from...Antimicrobial effect against |i|Aggregatibacter actinomycetemcomitans|/i| of advanced and injectable platelet-rich fibrin from...
Antimicrobial effect against Aggregatibacter actinomycetemcomitans of advanced and injectable platelet-rich fibrin from ... antimicrobial effects of these PRF materials against the periodontal pathogenic bacterium Aggregatibacter actinomycetemcomitans ...
https://pesquisa.bvsalud.org/odontologia/resource/pt/mdl-36937558
Interspecies Communication and Periodontal DiseaseInterspecies Communication and Periodontal Disease
A study demonstrated that P. gingivalis can detect AI-2 signal from Aggregatibacter actinomycetemcomitans, thus providing the ... and Aggregatibacter actinomycetemcomitans [6]. As the biofilm matures, there is proportional shift in the microbial components ... and interspecies regulation of gene expression by Actinobacillus actinomycetemcomitans LuxS," Infection and Immunity, vol. 69, ... "Occurrence of temperate bactenophages in different Actinobacillus actinomycetemcomitans serotypes isolated from periodontally ...
https://www.hindawi.com/journals/tswj/2013/765434/
Clinical Features and Comparison of Kingella and Non-Kingella Endocarditis in Children, Israel - Volume 27, Number 3-March 2021...
Aggregatibacter actinomycetemcomitans, Cardiobacterium hominis, Eikenella spp., and Kingella kingae) is a rare cause of IE, ...
https://wwwnc.cdc.gov/eid/article/27/3/20-3022_article
Clinical Features and Comparison of Kingella and Non-Kingella Endocarditis in Children, Israel - Volume 27, Number 3-March 2021...
Aggregatibacter actinomycetemcomitans, Cardiobacterium hominis, Eikenella spp., and Kingella kingae) is a rare cause of IE, ...
https://wwwnc.cdc.gov/eid/article/27/3/20-3022
HACEK Group Infections Clinical Presentation: History, Physical, CausesHACEK Group Infections Clinical Presentation: History, Physical, Causes
Actinobacillus actinomycetemcomitans, Cardiobacterium hominis, Eikenella corrodens, and Kingella species. These organisms share ... Endocarditis due to Aggregatibacter (formerly: Actinobacillus) actinomycetemcomitans, a bacterium that grows in characteristic ... Westling K, Vondracek M. Actinobacillus (Aggregatibacter) actinomycetemcomitans (HACEK) identified by PCR/16S rRNA sequence ... Infection due to Actinobacillus actinomycetemcomitans: 15 cases and review. Rev Infect Dis. 1989 Jan-Feb. 11 (1):46-63. [QxMD ...
https://emedicine.medscape.com/article/218158-clinical
The Journal of Contemporary Dental PracticeThe Journal of Contemporary Dental Practice
... actinomycetemcomitans. Porphyromonas gingivalis was susceptible to EGE compared with AGE. Aggregatibacter actinomycetemcomitans ... Keywords : Aggregatibacter actinomycetemcomitans, Antimicrobial, Guava, Porphyromonas gingivalis, Psidium guajava. Citation ... Interactions of extracts from selected chewing stick sources with Aggregatibacter actinomycetemcomitans. BMC Res Notes 2012 Jul ... The MIC determined for AGE was at 50 μL/mL for A. actinomycetemcomitans, whereas MIC determined for EGE was at 3.12 μL/mL for A ...
https://www.thejcdp.com/abstractArticleContentBrowse?jCode=JCDP&jid=19&abstractArticle=abstractArticle&documentType=Article&art_volume=19&art_issue=6&id=12016
Isak Demirel - Institutionen för medicinska vetenskaper - Örebro universitetIsak Demirel - Institutionen för medicinska vetenskaper - Örebro universitet
5. How does Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans contribute to oral-and systemic disease? ...
https://www.oru.se/personal/isak_demirel
Killing of human myelomonocytic leukemia and lymphocytic cell lines by Actinobacillus actinomycetemcomitans leukotoxin<...Killing of human myelomonocytic leukemia and lymphocytic cell lines by Actinobacillus actinomycetemcomitans leukotoxin<...
Aggregatibacter actinomycetemcomitans Medicine & Life Sciences 84% * leukemia Agriculture & Biology 66% * cell lines ... The purified leukotoxin of Actinobacillus actinomycetemcomitans kills human leukemic cell lines (e.g., HL-60, U937, and KG-1) ... N2 - The purified leukotoxin of Actinobacillus actinomycetemcomitans kills human leukemic cell lines (e.g., HL-60, U937, and KG ... AB - The purified leukotoxin of Actinobacillus actinomycetemcomitans kills human leukemic cell lines (e.g., HL-60, U937, and KG ...
https://experts.umn.edu/en/publications/killing-of-human-myelomonocytic-leukemia-and-lymphocytic-cell-lin
Dana Dawson - Research output - The University of Aberdeen Research PortalDana Dawson - Research output - The University of Aberdeen Research Portal
Aud Publishing - 7706 产品 | 页 4Aud Publishing - 7706 产品 | 页 4
Enzyme, Periodontal pathogen, Aggregatibacter actinomycetemcomitans, Catalysis, Hydrolysis, Gram-positive bacteria. 生物学 Aud ...
https://morebooks.de/books/cn/published_by/aud-publishing/189840/products?currency=BRL&page=4
Professor Iain Chapple - School of Dentistry - University of BirminghamProfessor Iain Chapple - School of Dentistry - University of Birmingham
CD18 mediates neutrophil imperviousness to the Aggregatibacter actinomycetemcomitans JP2 clone in molar-incisor pattern ...
https://www.birmingham.ac.uk/staff/profiles/clinical-sciences/chapple-iain.aspx
Quantitative difference of oral pathogen between individuals with gastric cancer and individuals without cancer | OncotargetQuantitative difference of oral pathogen between individuals with gastric cancer and individuals without cancer | Oncotarget
... including Aggregatibacter actinomycetemcomitans (A. actinomycetemcomitans), Treponema denticola (T. denticola), Porphyromonas ... A. actinomycetemcomitans (Aa). 2.3594. (2.1367-2.5992). 0.9280. (0.8140-1.1065). ,0.001. P. gingivalis (Pg). 1.3808. (1.2485- ... A. actinomycetemcomitans (Aa). 1.7214. (1.6410-1.8276). 1.5863. (1.4225-1.6838). ,0.001. P. gingivalis (Pg). 6.5364. (5.4225- ... A. actinomycetemcomitans (Aa). 0.9280. 2.6027. (,0.001). 2.0648. (,0.001). 2.2591. (,0.001). 2.3052. (,0.001). 2.2635. (,0.001) ...
https://www.oncotarget.com/article/28034/text/
Council on Microbial Sciences Members | ASM.orgCouncil on Microbial Sciences Members | ASM.org
... transcription and gene regulation of flp fimbriae from the periodontal pathogen Aggregatibacter actinomycetemcomitans. Other ...
https://asm.org/Council-on-Microbial-Sciences/Council-member-Landing
Biomedical Glasses Volume 4 Issue 1Biomedical Glasses Volume 4 Issue 1
Mono-species biofilms of Aggregatibacter actinomycetemcomitans (A. a), Porphyromonas gingivalis (P. g), and Prevotella ...
https://www.degruyter.com/journal/key/bglass/4/1/html
The Development of a Remote Restart Services System in Production Line Using PowerShell Script
Against Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans. By Haslinda Ramli, Zalina Baharudin and Rohazila ...
https://www.akademisains.gov.my/asmsj/article/the-development-of-a-remote-restart-services-system-in-production-line-using-powershell-script/
Paul J. Planet, MD, PhD | Childrens Hospital of PhiladelphiaPaul J. Planet, MD, PhD | Children's Hospital of Philadelphia
Karched M, Furgang D, Planet PJ, DeSalle R, and Fine DH (2012) Genome Sequence of Aggregatibacter actinomycetemcomitans RHAA1 ... localizes to a pole in Aggregatibacter actinomycetemcomitans. Mol Micro PMID: 22239271. ... Kachlany SC, Planet PJ, DeSalle R, Fine DH, Figurski DH (2001) Tight adherence by Actinobacillus actinomycetemcomitans: from ... 2009). Complete genome sequence of Aggregatibacter (Haemophilus) aphrophilus NJ8700. J Bacteriol 191(14): 4693-4694. ...
https://www.chop.edu/doctors/planet-paul-j
Microbiota diversity and gene expression dynamics in human oral biofilms | BMC Genomics | Full TextMicrobiota diversity and gene expression dynamics in human oral biofilms | BMC Genomics | Full Text
Periasamy S, Kolenbrander PE: Aggregatibacter actinomycetemcomitans builds mutualistic biofilm communities with Fusobacterium ... The left panel shows a strong negative (ρ ~ - 0.75) correlation between Actinomyces and Aggregatibacter through time. In the ... Bhattacharjee MK, Fine DH, Figurski DH: tfoX (sxy)-dependent transformation of Aggregatibacter (Actinobacillus) ... and Aggregatibacter (Proteobacteria), the latter showing strong negative correlations against 11 out of 15 different genera of ...
https://bmcgenomics.biomedcentral.com/articles/10.1186/1471-2164-15-311
KoreaMedKoreaMed
Porphyromonas gingivalis (Pg), Aggregatibacter actinomycetemcomitans (Aa), Tannerella forsythia (Tf), Prevotella intermedia (Pi ...
https://www.koreamed.org/SearchBasic.php?QY=%28%22Lipopolysaccharides%22%5BKW%5D%29
Kingella Infections - Infectious Diseases - Merck Manuals Professional EditionKingella Infections - Infectious Diseases - Merck Manuals Professional Edition
Aggregatibacter actinomycetemcomitans, Cardiobacterium hominis, Eikenella corrodens, Kingella kingae) includes weakly... read ... Aggregatibacter actinomycetemcomitans, Cardiobacterium hominis, Eikenella corrodens, Kingella kingae), which includes ...
https://www.merckmanuals.com/en-pr/professional/infectious-diseases/gram-negative-cocci-and-coccobacilli/kingella-infections
Actinomyces | Johns Hopkins ABX GuideActinomyces | Johns Hopkins ABX Guide
... of HACEK is Actinobacillus actinomycetemcomitans now known as Aggregatibacter actinomycetemcomitans). *CNS: meningitis (rare), ... Nearly always part of a mixed infection, especially with flora such as Actinobacillus actinomycetemcomitans, Eikenella ...
https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540005/all/Actinomyces?q=Oxacillin
HOMD :: SEQF3500HOMD :: SEQF3500
Genome Explorer: Aggregatibacter actinomycetemcomitans PN_439 (SEQF3500). Choose a Genome: Choose.... Abiotrophia defectiva ...
https://homd.org/genome/explorer?gid=SEQF3500&anno=ncbi&page=2
Jaw Infection | Causes | Symptoms | TreatmentJaw Infection | Causes | Symptoms | Treatment
Aggregatibacter actinomycetemcomitans.. * Prevotella intermedia.. * Fusobacteria.. * Tannerella forsythia.. B. Endodontic and ...
https://www.icliniq.com/articles/dental-oral-health/jaw-infection
Marcelo Freire | J. Craig Venter InstituteMarcelo Freire | J. Craig Venter Institute
Development of an animal model for Aggregatibacter actinomycetemcomitans biofilm-mediated oral osteolytic infection: a ...
https://pathema.jcvi.org/about/marcelo-freire
ActinobacillusPorphyromonasHaemophilusBacteriumSpeciesIntermediaGenusChronic PeriodontitisAntimicrobialPeriodontitisKlingerStrainClassificationBacteriaGingivalisIsolatesFusobacteriumPathogensAphrophilusPresence of Aggregatibacter actinomycetemcomitansSerotypeLeukotoxinPeriodontitisBacteriaBiofilmStrainsLeast 50 percent1912GenotypeSegnisAbstractSubgingivalPrevalenceAlbicansPatientsInfectionPlaqueMedicineResearch
Actinobacillus8
  • Norskov-Lauritsen N, Kilian M. Reclassification of Actinobacillus actinomycetemcomitans , Haemophilus aphrophilus , Haemophilus paraphrophilus and Haemophilus segnis as Aggregatibacter actinomycetemcomitans gen. nov., comb. (dsmz.de)
  • The purified leukotoxin of Actinobacillus actinomycetemcomitans kills human leukemic cell lines (e.g. (umn.edu)
  • Nearly always part of a mixed infection, especially with flora such as Actinobacillus actinomycetemcomitans, Eikenella corrodens , Bacteroides spp , S. aureus , Streptococcus spp . (hopkinsguides.com)
  • Three of 12 CHD patients but no control patient had Actinobacillus actinomycetemcomitans (A.a. (elsevier.com)
  • The authors have previously shown that the periodontal pathogen Aggregatibacter (formerly Actinobacillus ) actinomycetemcomitans Y4 contains an operon for a genotoxin known as the cytolethal distending toxin (Cdt). (microbiologyresearch.org)
  • Prevalence of cdtABC genes encoding cytolethal distending toxin among Haemophilus ducreyi and Actinobacillus actinomycetemcomitans strains. (microbiologyresearch.org)
  • Identification and characterization of genetic cluster groups of Actinobacillus actinomycetemcomitans isolated from the human oral cavity. (microbiologyresearch.org)
  • Detection of cytolethal distending toxin activity and cdt genes in Actinobacillus actinomycetemcomitans isolates from geographically diverse populations. (microbiologyresearch.org)
Porphyromonas5
  • The present cross-sectional study aimed to verify the prevalence of three periodontal pathogens, Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Prevotella intermedia, on different groups, with and without teeth. (bvsalud.org)
  • Aim: The present study was undertaken to assess the inhibitory effect of guava extracts on Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans, to assess the time-kill curve of P. gingivalis and A. actinomycetemcomitans, and to determine the antiproteolytic activity of guava on P. gingivalis. (thejcdp.com)
  • 5. How does Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans contribute to oral-and systemic disease? (oru.se)
  • Microbiota plays a major role in the etiopathogenesis of these diseases, including Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Prevotella intermedia, Tannerella forsythia and Fusobacterium nucleatum. (scielo.edu.uy)
  • LPS was extracted from Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, and Tannerella forsythia, and PGN was isolated from S. sanguinis. (scite.ai)
Haemophilus2
  • HACEK Infections The HACEK group ( Haemophilus species, Aggregatibacter actinomycetemcomitans , Cardiobacterium hominis , Eikenella corrodens , Kingella kingae ) includes weakly. (merckmanuals.com)
  • group ( Haemophilus species, Aggregatibacter actinomycetemcomitans , Cardiobacterium hominis , Eikenella corrodens , Kingella kingae ), which includes fastidious gram-negative bacteria capable of causing endocarditis. (merckmanuals.com)
Bacterium3
  • Aggregatibacter actinomycetemcomitans CCUG 46863 is a microaerophile, mesophilic bacterium that was isolated from Human blood,58-yr-f,valve prosthesis,endocarditis. (dsmz.de)
  • This study aimed to compare the antimicrobial effects of these PRF materials against the periodontal pathogenic bacterium Aggregatibacter actinomycetemcomitans (Aa) in patients with different periodontal conditions. (bvsalud.org)
  • The enzyme has been characterized from the bacterium Aggregatibacter actinomycetemcomitans , in which it participates in the biosynthesis of the serotype c-specific polysaccharide antigen. (enzyme-database.org)
Species1
  • Aggregatibacter actinomycetemcomitans (A.a.) was the strongest species associated with diseased sites. (uky.edu)
Intermedia1
  • In the localized disorders, P. intermedia, F. nucleatum and A. actinomycetemcomitans were the main ones. (scielo.edu.uy)
Genus1
  • Nomenclatural type of the genus Aggregatibacter Nørskov-Lauritsen and Kilian 2006 . (dsmz.de)
Chronic Periodontitis1
  • Aim: Aggregatibacter actinomycetemcomitans implicated in the etiology of aggressive, chronic periodontitis and other systemic infections. (who.int)
Antimicrobial1
  • Antimicrobial effect against Aggregatibacter actinomycetemcomitans of advanced and injectable platelet-rich fibrin from patients with periodontal diseases versus periodontally healthy subjects. (bvsalud.org)
Periodontitis2
  • Conclusion: Guava extract may be a potential therapeutic agent for periodontitis as it shows significant activity against both P. gingivalis and A. actinomycetemcomitans . (thejcdp.com)
  • Conclusion: Essential oil of Syzygium aromaticum showed good antibacterial activity and can be considered as alternative treatment option for control of periodontitis and other orodental infections caused by A.actinomycetemcomitans. (who.int)
Klinger2
  • To download a certificate of analysis for Aggregatibacter actinomycetemcomitans (Klinger 1912) Nørskov-Lauritsen and Kilian 2006 ( 43717 ), enter the lot number exactly as it appears on your product label or packing slip. (atcc.org)
  • The certificate of analysis for that lot of Aggregatibacter actinomycetemcomitans (Klinger 1912) Nørskov-Lauritsen and Kilian 2006 ( 43717 ) is not currently available online. (atcc.org)
Strain2
  • For the assessment of antibody to A. actinomycetemcomitans, a mixed suspension of three strains (ATCC#43718, #29523 and #33384) was used (A. actinomycemtecomitans mix) as well as individual preparations from A. actinomycemtecomitans serotype a (ATCC strain #29523) and serotype b (ATCC strain #43718, Y4). (cdc.gov)
  • Schröder A , Stumpf J , Paddenberg E , Neubert P , Schatz V , Köstler J , Jantsch J , Deschner J , Proff P , Kirschneck C . Effects of mechanical strain on periodontal ligament fibroblasts in presence of Aggregatibacter actinomycetemcomitans lysate. (wjgnet.com)
Classification1
  • Norskov-Lauritsen N, Claesson R, Birkeholm Jensen A, Aberg CH, Haubek D. Aggregatibacter Actinomycetemcomitans: Clinical Significance of a Pathobiont Subjected to Ample Changes in Classification and Nomenclature. (dsmz.de)
Bacteria1
  • On this week's episode of Fast Facts - Perio Edition your host, Katrina Sanders, RDH talks to us about bacteria outlier, Aggregatibacter actinomycetemcomitans! (libsyn.com)
Gingivalis2
  • Materials and methods: Kanamycin blood agar was used to isolate P. gingivalis and A. actinomycetemcomitans . (thejcdp.com)
  • Aggregatibacter actinomycetemcomitans was more susceptible to guava extracts compared with P. gingivalis . (thejcdp.com)
Isolates3
  • nov., and emended description of Aggregatibacter aphrophilus to include V factor-dependent and V factor-independent isolates. (dsmz.de)
  • IMSEAR at SEARO: Antibacterial Activity of Essential Oil of Syzygium Aromaticum (L.) Merr.Perry (Cloves) Against Clinical Isolates of Aggregatibacter Actinomycetemcomitans. (who.int)
  • The aim of this study was to investigate the antibacterial efficacy of essential oil of a traditional medicinal plant, Syzygium aromaticum (L.) Merr.perry (cloves) against the clinical isolates of A.actinomycetemcomitans obtained from the patients with orodental infections. (who.int)
Fusobacterium1
Pathogens5
  • Aggregatibacter actinomycetemcomitans, a Gram-negative bacterium, and Candida albicans, a polymorphic fungus, are both commensals of the oral cavity but both are opportunistic pathogens that can cause oral diseases. (vu.nl)
  • The present cross-sectional study aimed to verify the prevalence of three periodontal pathogens, Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Prevotella intermedia, on different groups, with and without teeth. (bvsalud.org)
  • Ethylenediamine-N,N,N',N'-tetraacetic acid calcium (II) disodium salt (Ca (II)-EDTA) was investigated for its antibacterial activity against the periodontal pathogens Aggregatibacter actinomycetemcomitans, Prevotella intermedia and Porphyromonas gingivalis. (scirp.org)
  • Haplotype block rs1057028 was also significantly associated with pathogens Fusobacterium nucleatum and Aggregatibacter actinomycetemcomitans, increased GCF-IL-1β levels, and extent of probing depth ≥4 mm (P ≤0.05). (nih.gov)
  • Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis are classic periodontal pathogens. (invivohealthcare.com)
Aphrophilus2
  • Serological studies have been attempted to determine the antigenic relationship between A. actinomycetemcomitans and Haemophilus aphrophilus . (periobasics.com)
  • nov., and emended description of Aggregatibacter aphrophilus to include V factor-dependent and V factor-independent isolates. (dsmz.de)
Presence of Aggregatibacter actinomycetemcomitans1
  • Genetic factors have recently been associated with presence of Aggregatibacter actinomycetemcomitans subgingivally in populations living in industrialized countries. (nih.gov)
Serotype2
  • It is important to note that serotype b of A. actinomycetemcomitans has been found more frequently and detected in higher numbers in active periodontitis lesions, whereas serotype a and c have a stronger association with periodontal health 100 . (periobasics.com)
  • For the assessment of antibody to A. actinomycetemcomitans, a mixed suspension of three strains (ATCC#43718, #29523 and #33384) was used (A. actinomycemtecomitans mix) as well as individual preparations from A. actinomycemtecomitans serotype a (ATCC strain #29523) and serotype b (ATCC strain #43718, Y4). (cdc.gov)
Leukotoxin2
  • 2. Aggregatibacter actinomycetemcomitans Leukotoxin (LtxA) Requires Death Receptor Fas, in Addition to LFA-1, To Trigger Cell Death in T Lymphocytes. (nih.gov)
  • 20. Aggregatibacter actinomycetemcomitans leukotoxin utilizes a cholesterol recognition/amino acid consensus site for membrane association. (nih.gov)
Periodontitis3
  • Abstract: The Gram negative pathogen, Aggregatibacter actinomycetemcomitans, is the etiologic agent of localized aggressive periodontitis (LAP) and other systemic infections, including infective endocarditis. (nih.gov)
  • Hay patobiontes específicos que han mostrado patogenicidad al alterar la tolerancia inmune del huésped, causando una inflamación crónica en los tejidos periodontales que conduce a los cambios destructivos en el tejido conectivo y óseo que caracterizan a la periodontitis. (ucm.es)
  • A pesar de que el factor etiológico principal de la periodontitis son los microorganismos que residen en la biopelícula subgingival, sólo un pequeño grupo de bacterias se ha asociado directamente con el inicio y la progresión de esta enfermedad, principalmente las implicadas en el cambio de la microbiota en estado simbiótico al estado disbiótico. (ucm.es)
Bacteria3
  • Structurally, A. actinomycetemcomitans are Gram-negative, small non-motile coccobacilli that grow singly, in pairs, or in small clumps and are described as fastidious and CO 2 -requiring bacteria. (periobasics.com)
  • In one test-tube study, Frankincense & Myrrh extract was effective against Aggregatibacter actinomycetemcomitans , a bacteria which causes aggressive gum disease ( 19Trusted Source ). (wm-gift.com)
  • Among bacteria associated with periodontal disease, the research team found that A. actinomycetemcomitans was the only one able to induce hypercitrullination in neutrophils, a white blood cell and part of the immune system. (naturallyepic.com)
Biofilm3
  • A. actinomycetemcomitans adhered to C. albicans and inhibited biofilm formation by means of a molecule that was secreted during growth. (vu.nl)
  • C. albicans biofilm formation increased significantly when co-cultured with A. actinomycetemcomitans luxS, lacking AI-2 production. (vu.nl)
  • AI-2 of A. actinomycetemcomitans is synthesized by LuxS, accumulates during growth and inhibits C. albicans hypha- and biofilm formation. (vu.nl)
Strains1
  • The agar dilution method showed CHX was more effective as compared to the herbal mouthwash against standard strains of Streptococcus mutans , Streptococcus sanguinis , and Aggregatibacter actinomycetemcomitans . (jisponline.com)
Least 50 percent2
  • Additionally, patients whose biomes contained Aggregatibacter actinomycetemcomitans were at least 50 percent more likely to develop pancreatic cancer. (mckinneysmiles.com)
  • Similarly, individuals with Aggregatibacter actinomycetemcomitans in their oral microbiomes were at least 50 percent more susceptible to developing the disease. (biogenics16.com)
19121
  • This bacterium was first isolated by Klinger 81 from a cervicofacial actinomycotic lesion in 1912 and was named Bacterium actinomycetemcomitans . (periobasics.com)
Genotype1
  • The IL6-74 GG genotype was associated with high (above median) counts of A. actinomycetemcomitans (both in all subjects and in periodontally healthy only) and with presence and counts of Capnocytophaga sputigena. (nih.gov)
Segnis1
  • nov. and Aggregatibacter segnis comb. (dsmz.de)
Abstract1
  • Abstract Background The aim of this study was to evaluate the effects of ß-glucan on the expression of inflammatory mediators and metabolomic profile of oral cells [keratinocytes (OBA-9) and fibroblasts (HGF-1) in a dual-chamber model] infected by Aggregatibacter actinomycetemcomitans. (uncg.edu)
Subgingival1
  • The aim of this study was to analyse associations between Interleukin-6 (IL6) single nucleotide polymorphisms and presence and levels of A. actinomycetemcomitans and other subgingival microbes in a rural Indian population. (nih.gov)
Prevalence1
  • Prevalence of C. rectus was higher in smokers than non-smokers, whereas that of A. actinomycetemcomitans was lower in smokers. (robmosaic.com)
Albicans1
  • The aim of this study was to investigate the role of AI-2 based signaling in the interactions between C. albicans and A. actinomycetemcomitans. (vu.nl)
Patients1
  • Of patients with A actinomycetemcomitans IE, 86% have underlying heart disease and 25% have infection of a prosthetic valve (usually aortic). (medscape.com)
Infection2
  • The toxin kills human and primate white blood cells and likely plays a role in A. actinomycetemcomitans evasion of the immune response during infection. (nih.gov)
  • Andrade cautioned that more than 50 percent of study participants who had RA had no evidence of infection with A. actinomycetemcomitans. (naturallyepic.com)
Plaque1
  • A. actinomycetemcomitans is grown in anaerobic cultures and from plaque, it can be rapidly identified by fluorescent labelled antisera. (periobasics.com)
Medicine1
  • In the journal Science Translational Medicine, the investigators identify the common denominator in gum disease and in many people with RA as Aggregatibacter actinomycetemcomitans. (naturallyepic.com)
Research1
  • To determine if A. actinomycetemcomitans causes RA, more research is needed, the Johns Hopkins team says. (naturallyepic.com)
Interspecies Communication and Periodontal Disease
Interspecies Communication and Periodontal Disease (hindawi.com)
Meningitis Lab Manual: ID and Characterization of Hib | CDC
Meningitis Lab Manual: ID and Characterization of Hib | CDC (cdc.gov)
The Journal of Contemporary Dental Practice
The Journal of Contemporary Dental Practice (thejcdp.com)
Isak Demirel - Institutionen för medicinska vetenskaper - Örebro universitet
Isak Demirel - Institutionen för medicinska vetenskaper - Örebro universitet (oru.se)
Aud Publishing - 7706 Produits | Page 4
Aud Publishing - 7706 Produits | Page 4 (morebooks.de)
Professor Iain Chapple - School of Dentistry - University of Birmingham
Professor Iain Chapple - School of Dentistry - University of Birmingham (birmingham.ac.uk)
Quantitative difference of oral pathogen between individuals with gastric cancer and individuals without cancer | Oncotarget
Quantitative difference of oral pathogen between individuals with gastric cancer and individuals without cancer | Oncotarget (oncotarget.com)
Biomedical Glasses Volume 4 Issue 1
Biomedical Glasses Volume 4 Issue 1 (degruyter.com)
Einsatz von Carpegen Perio Diagnostik | Carpegen GmbH
Einsatz von Carpegen Perio Diagnostik | Carpegen GmbH (carpegen.de)
Paul J. Planet, MD, PhD | Children's Hospital of Philadelphia
Paul J. Planet, MD, PhD | Children's Hospital of Philadelphia (chop.edu)
Microbiota diversity and gene expression dynamics in human oral biofilms | BMC Genomics | Full Text
Microbiota diversity and gene expression dynamics in human oral biofilms | BMC Genomics | Full Text (bmcgenomics.biomedcentral.com)
Kingella Infections - Infectious Diseases - Merck Manuals Professional Edition
Kingella Infections - Infectious Diseases - Merck Manuals Professional Edition (merckmanuals.com)
Factores asociados a la susceptibilidad a periodontitis agresiva - Revisión de la literatura
Factores asociados a la susceptibilidad a periodontitis agresiva - Revisión de la literatura (actaodontologica.com)
Jaw Infection | Causes | Symptoms | Treatment
Jaw Infection | Causes | Symptoms | Treatment (icliniq.com)
Marcelo Freire | J. Craig Venter Institute
Marcelo Freire | J. Craig Venter Institute (pathema.jcvi.org)
Plasmodium ovale | Mmolecular
Plasmodium ovale | Mmolecular (mmolecular.com)
Ellen Jo Baron's Profile | Stanford Profiles
Ellen Jo Baron's Profile | Stanford Profiles (profiles.stanford.edu)
Relative avidity of serum immunoglobulin G antibody for the fimbria antigen of Actinobacillus actinomycetemcomitans in patients...
Relative avidity of serum immunoglobulin G antibody for the fimbria antigen of Actinobacillus actinomycetemcomitans in patients... (keio.pure.elsevier.com)
A faecal microbiota signature with high specificity for pancreatic cancer | Gut
A faecal microbiota signature with high specificity for pancreatic cancer | Gut (gut.bmj.com)
SciELO RevOdonto - revodonto.bvsalud.org
SciELO RevOdonto - revodonto.bvsalud.org (revodonto.bvsalud.org)
Find Research outputs - Universitas Indonesia
Find Research outputs - Universitas Indonesia (scholar.ui.ac.id)
The Association Between Oral Health and Skin Disease - JCAD | The Journal of Clinical and Aesthetic Dermatology
The Association Between Oral Health and Skin Disease - JCAD | The Journal of Clinical and Aesthetic Dermatology (jcadonline.com)
Association of levels of antibodies against citrullinated cyclic peptides and citrullinated α-enolase in chronic and aggressive...
Association of levels of antibodies against citrullinated cyclic peptides and citrullinated α-enolase in chronic and aggressive... (translational-medicine.biomedcentral.com)
Epidemiology and Health Promotion - Research output - NYU Scholars
Epidemiology and Health Promotion - Research output - NYU Scholars (nyuscholars.nyu.edu)
Anti-Periodontopathic Antibody Response in Chronic HIV Infection
Anti-Periodontopathic Antibody Response in Chronic HIV Infection (sciforschenonline.org)
HOMD :: SEQF3481
HOMD :: SEQF3481 (ehomd.org)