Substances, usually of biological origin, that cause cells or other organic particles to aggregate and stick to each other. They include those ANTIBODIES which cause aggregation or agglutination of particulate or insoluble ANTIGENS.
Lectins purified from the germinating seeds of common wheat (Triticum vulgare); these bind to certain carbohydrate moieties on cell surface glycoproteins and are used to identify certain cell populations and inhibit or promote some immunological or physiological activities. There are at least two isoforms of this lectin.
Lectin purified from peanuts (ARACHIS HYPOGAEA). It binds to poorly differentiated cells and terminally differentiated cells and is used in cell separation techniques.
Protein or glycoprotein substances of plant origin that bind to sugar moieties in cell walls or membranes. Some carbohydrate-metabolizing proteins (ENZYMES) from PLANTS also bind to carbohydrates, however they are not considered lectins. Many plant lectins change the physiology of the membrane of BLOOD CELLS to cause agglutination, mitosis, or other biochemical changes. They may play a role in plant defense mechanisms.
Proteins that share the common characteristic of binding to carbohydrates. Some ANTIBODIES and carbohydrate-metabolizing proteins (ENZYMES) also bind to carbohydrates, however they are not considered lectins. PLANT LECTINS are carbohydrate-binding proteins that have been primarily identified by their hemagglutinating activity (HEMAGGLUTININS). However, a variety of lectins occur in animal species where they serve diverse array of functions through specific carbohydrate recognition.
Glycoprotein molecules on the surface of B- and T-lymphocytes, that react with molecules of antilymphocyte sera, lectins, and other agents which induce blast transformation of lymphocytes.
Abnormal immunoglobulins, especially IGG or IGM, that precipitate spontaneously when SERUM is cooled below 37 degrees Celsius. It is characteristic of CRYOGLOBULINEMIA.
The clumping together of suspended material resulting from the action of AGGLUTININS.
Common name for Ricinus communis, a species in the family EUPHORBIACEAE. It is the source of CASTOR OIL.
Tests that are dependent on the clumping of cells, microorganisms, or particles when mixed with specific antiserum. (From Stedman, 26th ed)
A plant genus of the family EUPHORBIACEAE, order Euphorbiales, subclass Rosidae. The seed of Ricinus communis L. is the CASTOR BEAN which is the source of CASTOR OIL; RICIN; and other lectins.
A plant genus in the family LILIACEAE (sometimes classified as Amaryllidaceae). Galanthus nivalis L. is the source of GALANTHAMINE.
A MANNOSE/GLUCOSE binding lectin isolated from the jack bean (Canavalia ensiformis). It is a potent mitogen used to stimulate cell proliferation in lymphocytes, primarily T-lymphocyte, cultures.
A plant species of the family FABACEAE that yields edible seeds, the familiar peanuts, which contain protein, oil and lectins.
The N-acetyl derivative of galactosamine.
The aggregation of ERYTHROCYTES by AGGLUTININS, including antibodies, lectins, and viral proteins (HEMAGGLUTINATION, VIRAL).
Acquired hemolytic anemia due to the presence of AUTOANTIBODIES which agglutinate or lyse the patient's own RED BLOOD CELLS.
The largest class of organic compounds, including STARCH; GLYCOGEN; CELLULOSE; POLYSACCHARIDES; and simple MONOSACCHARIDES. Carbohydrates are composed of carbon, hydrogen, and oxygen in a ratio of Cn(H2O)n.
Cell surface receptors that bind to ACETYLGLUCOSAMINE.
Sensitive tests to measure certain antigens, antibodies, or viruses, using their ability to agglutinate certain erythrocytes. (From Stedman, 26th ed)
Carbohydrates covalently linked to a nonsugar moiety (lipids or proteins). The major glycoconjugates are glycoproteins, glycopeptides, peptidoglycans, glycolipids, and lipopolysaccharides. (From Biochemical Nomenclature and Related Documents, 2d ed; From Principles of Biochemistry, 2d ed)
The N-acetyl derivative of glucosamine.
A toxic lectin from the seeds of jequirity, Abrus precatorius L. Very active poison. Five different proteins have so far been isolated: Abrus agglutinin, the component responsible for: hemagglutinating activity, & abrins a-d, the toxic principals each consisting of two peptide chains are held together by disulfide bonds.
Proteins which are present in or isolated from SOYBEANS.
A plant species of the genus DATURA, family SOLANACEAE, that contains TROPANES and other SOLANACEOUS ALKALOIDS.
Conjugated protein-carbohydrate compounds including mucins, mucoid, and amyloid glycoproteins.
The sequence of carbohydrates within POLYSACCHARIDES; GLYCOPROTEINS; and GLYCOLIPIDS.
N-Glycosidases that remove adenines from RIBOSOMAL RNA, depurinating the conserved alpha-sarcin loop of 28S RIBOSOMAL RNA. They often consist of a toxic A subunit and a binding lectin B subunit. They may be considered as PROTEIN SYNTHESIS INHIBITORS. They are found in many PLANTS and have cytotoxic and antiviral activity.
Glycoprotein moieties on the surfaces of cell membranes that bind concanavalin A selectively; the number and location of the sites depends on the type and condition of the cell.
A chromatographic technique that utilizes the ability of biological molecules to bind to certain ligands specifically and reversibly. It is used in protein biochemistry. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Agents that cause agglutination of red blood cells. They include antibodies, blood group antigens, lectins, autoimmune factors, bacterial, viral, or parasitic blood agglutinins, etc.
Ribosome inactivating proteins consisting of two polypeptide chains, the toxic A subunit and a lectin B subunit, linked by disulfide bridges. The lectin portion binds to cell surfaces and facilitates transport into the ENDOPLASMIC RETICULUM.
A blood group related both to the ABO and P systems that includes several different antigens found in most people on erythrocytes, in milk, and in saliva. The antibodies react only at low temperatures.
An enzyme that catalyzes the hydrolysis of alpha-2,3, alpha-2,6-, and alpha-2,8-glycosidic linkages (at a decreasing rate, respectively) of terminal sialic residues in oligosaccharides, glycoproteins, glycolipids, colominic acid, and synthetic substrate. (From Enzyme Nomenclature, 1992)
A group of naturally occurring N-and O-acyl derivatives of the deoxyamino sugar neuraminic acid. They are ubiquitously distributed in many tissues.
Agglutination of spermatozoa by antibodies or autoantibodies.
The characteristic 3-dimensional shape of a carbohydrate.
Carbohydrates consisting of between two (DISACCHARIDES) and ten MONOSACCHARIDES connected by either an alpha- or beta-glycosidic link. They are found throughout nature in both the free and bound form.
An aldohexose that occurs naturally in the D-form in lactose, cerebrosides, gangliosides, and mucoproteins. Deficiency of galactosyl-1-phosphate uridyltransferase (GALACTOSE-1-PHOSPHATE URIDYL-TRANSFERASE DEFICIENCY DISEASE) causes an error in galactose metabolism called GALACTOSEMIA, resulting in elevations of galactose in the blood.
7-Hydroxycoumarins. Substances present in many plants, especially umbelliferae. Umbelliferones are used in sunscreen preparations and may be mutagenic. Their derivatives are used in liver therapy, as reagents, plant growth factors, sunscreens, insecticides, parasiticides, choleretics, spasmolytics, etc.
An N-acyl derivative of neuraminic acid. N-acetylneuraminic acid occurs in many polysaccharides, glycoproteins, and glycolipids in animals and bacteria. (From Dorland, 28th ed, p1518)
Cellular processes in biosynthesis (anabolism) and degradation (catabolism) of CARBOHYDRATES.
Study of intracellular distribution of chemicals, reaction sites, enzymes, etc., by means of staining reactions, radioactive isotope uptake, selective metal distribution in electron microscopy, or other methods.
A plant genus of the family FABACEAE. Members contain ABRIN.
The chemical or biochemical addition of carbohydrate or glycosyl groups to other chemicals, especially peptides or proteins. Glycosyl transferases are used in this biochemical reaction.
A polysaccharide-producing species of STREPTOCOCCUS isolated from human dental plaque.
The clear, viscous fluid secreted by the SALIVARY GLANDS and mucous glands of the mouth. It contains MUCINS, water, organic salts, and ptylin.
Antibodies which elicit IMMUNOPRECIPITATION when combined with antigen.
Mannosides formed by the reaction of the hydroxyl group on the anomeric carbon atom of mannose with methyl alcohol. They include both alpha- and beta-methylmannosides.
Electrophoresis in which a polyacrylamide gel is used as the diffusion medium.
The lectin wheatgerm agglutinin conjugated to the enzyme HORSERADISH PEROXIDASE. It is widely used for tracing neural pathways.
Carbohydrate antigens expressed by malignant tissue. They are useful as tumor markers and are measured in the serum by means of a radioimmunoassay employing monoclonal antibodies.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
A coumarin derivative possessing properties as a spasmolytic, choleretic and light-protective agent. It is also used in ANALYTICAL CHEMISTRY TECHNIQUES for the determination of NITRIC ACID.
Red blood cells. Mature erythrocytes are non-nucleated, biconcave disks containing HEMOGLOBIN whose function is to transport OXYGEN.
Plants or plant parts which are harmful to man or other animals.
Simple sugars, carbohydrates which cannot be decomposed by hydrolysis. They are colorless crystalline substances with a sweet taste and have the same general formula CnH2nOn. (From Dorland, 28th ed)
The lipid- and protein-containing, selectively permeable membrane that surrounds the cytoplasm in prokaryotic and eukaryotic cells.
A plant genus of the family POACEAE that is the source of EDIBLE GRAIN. A hybrid with rye (SECALE CEREALE) is called TRITICALE. The seed is ground into FLOUR and used to make BREAD, and is the source of WHEAT GERM AGGLUTININS.
Sets of cell surface antigens located on BLOOD CELLS. They are usually membrane GLYCOPROTEINS or GLYCOLIPIDS that are antigenically distinguished by their carbohydrate moieties.
A protein phytotoxin from the seeds of Ricinus communis, the castor oil plant. It agglutinates cells, is proteolytic, and causes lethal inflammation and hemorrhage if taken internally.
A hexose or fermentable monosaccharide and isomer of glucose from manna, the ash Fraxinus ornus and related plants. (From Grant & Hackh's Chemical Dictionary, 5th ed & Random House Unabridged Dictionary, 2d ed)
The parts of a macromolecule that directly participate in its specific combination with another molecule.
The sum of the weight of all the atoms in a molecule.
Glycosides formed by the reaction of the hydroxyl group on the anomeric carbon atom of galactose with an alcohol to form an acetal. They include both alpha- and beta-galactosides.
Oligosaccharides containing two monosaccharide units linked by a glycosidic bond.
A genus of filamentous CYANOBACTERIA in the order Oscillatoriales. It is commonly found in freshwater environments, especially hot springs.
A genus GREEN ALGAE in the order VOLVOCIDA. It consists of solitary biflagellated organisms common in fresh water and damp soil.
Serum that contains antibodies. It is obtained from an animal that has been immunized either by ANTIGEN injection or infection with microorganisms containing the antigen.
Parasitic plants that form a bushy growth on branches of host trees which are in the order Santalales. It includes the Christmas mistletoe family (VISCACEAE), the showy mistletoe family (LORANTHACEAE) and the catkin mistletoe family (Eremolepidaceae). The composition of toxins, lectins, tyramine, phenethylamines, and other compounds may be affected by the host.
Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).
Fluorescent probe capable of being conjugated to tissue and proteins. It is used as a label in fluorescent antibody staining procedures as well as protein- and amino acid-binding techniques.
A condition of inadequate circulating red blood cells (ANEMIA) or insufficient HEMOGLOBIN due to premature destruction of red blood cells (ERYTHROCYTES).
The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.
The cap-like structure covering the anterior portion of SPERM HEAD. Acrosome, derived from LYSOSOMES, is a membrane-bound organelle that contains the required hydrolytic and proteolytic enzymes necessary for sperm penetration of the egg in FERTILIZATION.
A class of immunoglobulin bearing mu chains (IMMUNOGLOBULIN MU-CHAINS). IgM can fix COMPLEMENT. The name comes from its high molecular weight and originally being called a macroglobulin.
A test to detect non-agglutinating ANTIBODIES against ERYTHROCYTES by use of anti-antibodies (the Coombs' reagent.) The direct test is applied to freshly drawn blood to detect antibody bound to circulating red cells. The indirect test is applied to serum to detect the presence of antibodies that can bind to red blood cells.
Serum globulins with high molecular weight. (Dorland, 28th ed)
The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.
A genus of chiefly Eurasian and African land snails including the principal edible snails as well as several pests of cultivated plants.
Specific, characterizable, poisonous chemicals, often PROTEINS, with specific biological properties, including immunogenicity, produced by microbes, higher plants (PLANTS, TOXIC), or ANIMALS.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
Proteins which contain carbohydrate groups attached covalently to the polypeptide chain. The protein moiety is the predominant group with the carbohydrate making up only a small percentage of the total weight.
Serologic tests in which a known quantity of antigen is added to the serum prior to the addition of a red cell suspension. Reaction result is expressed as the smallest amount of antigen which causes complete inhibition of hemagglutination.
Local surface sites on antibodies which react with antigen determinant sites on antigens (EPITOPES.) They are formed from parts of the variable regions of FAB FRAGMENTS.
Changes that occur to liberate the enzymes of the ACROSOME of a sperm (SPERMATOZOA). Acrosome reaction allows the sperm to penetrate the ZONA PELLUCIDA and enter the OVUM during FERTILIZATION.
An infraorder of CRUSTACEA, in the order DECAPODA comprising the hermit crabs and characterized by a small fifth pair of legs.
A plant genus of the family FABACEAE (sometimes classified as Papilionaceae). Members contain LECTINS.
A plant genus of the family ARACEAE. It has a stemless, tuberous root.
A disaccharide of GLUCOSE and GALACTOSE in human and cow milk. It is used in pharmacy for tablets, in medicine as a nutrient, and in industry.
Microscopy using an electron beam, instead of light, to visualize the sample, thereby allowing much greater magnification. The interactions of ELECTRONS with specimens are used to provide information about the fine structure of that specimen. In TRANSMISSION ELECTRON MICROSCOPY the reactions of the electrons that are transmitted through the specimen are imaged. In SCANNING ELECTRON MICROSCOPY an electron beam falls at a non-normal angle on the specimen and the image is derived from the reactions occurring above the plane of the specimen.
A strong oxidizing agent.
A trypanosome found in the blood of adult rats and transmitted by the rat flea. It is generally non-pathogenic in adult rats but can cause lethal infection in suckling rats.
Chromatography on non-ionic gels without regard to the mechanism of solute discrimination.
A subclass of anhydrides with the general structure of dihydrofurandione. They can be substituted on any carbon atom. They modify and inhibit proteins and enzymes and are used in the acylation of amino- and hydroxyl groups.
Plants whose roots, leaves, seeds, bark, or other constituent parts possess therapeutic, tonic, purgative, curative or other pharmacologic attributes, when administered to man or animals.
A linear polysaccharide of beta-1->4 linked units of ACETYLGLUCOSAMINE. It is the second most abundant biopolymer on earth, found especially in INSECTS and FUNGI. When deacetylated it is called CHITOSAN.
A genus of tiny mushrooms in the family Tricholomataceae. They help break down the decaying organic matter of the forest floor.
A serovar of the bacterial species LEPTOSPIRA INTERROGANS, whose natural host is DOGS where disease is characterized by GASTROENTERITIS, and INTERSTITIAL NEPHRITIS.
The major human blood type system which depends on the presence or absence of two antigens A and B. Type O occurs when neither A nor B is present and AB when both are present. A and B are genetic factors that determine the presence of enzymes for the synthesis of certain glycoproteins mainly in the red cell membrane.
A chemical reagent that reacts with and modifies chemically the tryptophan portion of protein molecules. Used for 'active site' enzyme studies and other protein studies. Sometimes referred to as Koshland's reagent.
The marking of biological material with a dye or other reagent for the purpose of identifying and quantitating components of tissues, cells or their extracts.
High molecular weight mucoproteins that protect the surface of EPITHELIAL CELLS by providing a barrier to particulate matter and microorganisms. Membrane-anchored mucins may have additional roles concerned with protein interactions at the cell surface.
An annual legume. The SEEDS of this plant are edible and used to produce a variety of SOY FOODS.
A basic science concerned with the composition, structure, and properties of matter; and the reactions that occur between substances and the associated energy exchange.
An absence of warmth or heat or a temperature notably below an accustomed norm.

Some leptospira agglutinins detected in domestic animals in British Columbia. (1/437)

During a period of six years 7,555 bovine sera, 421 canine sera, 251 porcine sera and 135 equine sera were tested for agglutinins to Leptospira interrogans serotypes canicola, grippotyphosa, hardjo, icterohemorrhagiae, pomona and sejroe. The bovine sera reacted predominantly with hardjo and/or sejroe at a rate of 15% compared to 3.5% with pomona. Breeding or abortion problems were associated with pomona but not with sejroe/hardjo agglutinins. The canine sera reacted to canicola (9.9%y and icterohemorrhagiae (5.4%), tcted predominantly with canicola (8.9%) and icterohemorrhagiae (8.1%).  (+info)

Platelet high affinity low density lipoprotein binding and import of lipoprotein derived phospholipids. (2/437)

The binding of low density lipoprotein (LDL) to the platelet cell membrane could facilitate the transfer of phospholipids from LDL to the platelets. A polyclonal antibody against the platelet glycoproteins IIb/IIIa inhibited the high affinity binding of 125I-LDL by up to 80%. The transfer of pyrene (py)-labeled sphingomyelin (SM), phosphatidylcholine and phosphatidylethanolamine from LDL to the platelets was unaffected by the antibody. The lectin wheat germ agglutinin (WGA) reduced the binding of 125I-LDL to the platelets by approximately 80%. In contrast, the lectin stimulated the transfer of SM from LDL into the platelets by about three-fold. WGA also specifically augmented the transfer of py-SM between lipid vesicles and the platelets, the stimulation being abolished in the presence of N-acetylglucosamine. Dextran sulfate (DS) increased the specific binding of 125I-LDL to the platelets by up to 2.8-fold. On the other hand, the import of LDL-derived py-phospholipids was unaffected by DS. Together, the results indicate that the phospholipid transfer from LDL to the platelets is independent of the high affinity LDL binding to the platelets and is specifically stimulated by WGA. Thus, the interactions of platelets with LDL phospholipids differ markedly from those with the apoprotein components of the lipoproteins.  (+info)

Role of nonagglutinating antibody in the protracted immunity of vaccinated mice to Pseudomonas aeruginosa infection. (3/437)

Effective immunization against infection with Pseudomonas aeruginosa is difficult to evaluate because agglutinin levels decline rapidly. Because fractionation of hyperimmune sera often yields more specific antibody than can be accounted for by direct agglutination tests, an immunoglobulin-specific assay based on antiglobulin augmentation was used to characterize antibody responses of C3H/HeJ mice vaccinated with P. aeruginosa type 2 lipopolysaccharide. Nonagglutinating antibodies, initially detected at 2 weeks post-primary vaccination, were predominantly immunoglobulin G after 5 weeks, and they remained elevated at levels usually 32-fold higher than the direct titer throughout the 4-month study period. The sequential production of immunoglobulin M, then immunoglobulin G, followed that found in orthodox immunological responses. Sera that contained nonagglutinating antibodies but not direct agglutinins (14 to 16 weeks) enhanced phagocytosis of P. aeruginosa type 2 by macrophages from unimmunized mice and passively immunized mice against lethal challenge doses; bactericidal activity of these sera was not demonstrated in the presence or absence of complement. When challenged with 1, 10, and 100 50% lethal doses at 16 weeks, survival rates of actively immunized mice were significantly higher than those of unvaccinated mice (P < 0.001). Thus, at a time when no direct agglutinins were detectable, the augmented system detected nonagglutinating antibodies that could confer protracted resistance in vaccinated mice to pseudomonas infection.  (+info)

Expression of DMBT1, a candidate tumor suppressor gene, is frequently lost in lung cancer. (4/437)

DMBT1 is a candidate tumor suppressor gene located at 10q25.3-26.1. Homozygous deletion of the gene was found in a subset of medulloblastoma and glioblastoma multiforme; lack of expression was noted in the majority of these tumors. In adult tissues, DMBT1 is highly expressed only in lung and small intestine tissues, indicating its important role in these organs. By analyzing lung cancer cell lines and primary lung tumors using reverse transcription-PCR, we found that 100% (20 of 20) of small cell lung cancer (SCLC) cell lines and 43% (6 of 14) of non-small cell lung cancer (NSCLC) cell lines lacked DMBT1 expression. Furthermore, 45% (9 of 20) of the primary NSCLCs exhibited a markedly low level of gene expression compared with corresponding normal lung tissues, indicating that lack of gene expression also occurs in primary lung cancers. To determine the potential mechanisms for lack of DMBT1 expression in lung cancer, we analyzed tumor cell lines for potential intragenic homozygous deletions of the gene and found such homozygous deletions in 10% (4 of 40) of SCLC cell lines but in none of 14 NSCLC cell lines. Moreover, the loss of expression could not be rescued by treatment with a demethylation agent (5-azacytidine) in two NSCLC cell lines lacking DMBT1 expression, suggesting that de novo methylation of the promoter region of the gene is unlikely to play a role in inactivation of the gene. We then sequenced the whole coding region of DMBT1 in 8 NSCLC cell lines that expressed DMBT1 and 20 primary NSCLCs. A potential point mutation at codon 52 was detected in a NSCLC cell line and resulted in an amino acid change from serine to tryptophan. Three common polymorphisms were also detected in tissues analyzed. Our data demonstrate that DMBT1 expression is frequently lost in lung cancer due to gene deletion and to other not yet identified mechanisms, suggesting that inactivation of DMBT1 may play an important role in lung tumorigenesis.  (+info)

Complement receptor 1 (CD35) on human reticulocytes: normal expression in systemic lupus erythematosus and HIV-infected patients. (5/437)

The low levels of complement receptor 1 (CR1) on erythrocytes in autoimmune diseases and AIDS may be due to accelerated loss in the circulation, or to a diminished expression of CR1 on the red cell lineage. Therefore, we analyzed the expression of CR1 on reticulocytes (R) vs erythrocytes (E). Healthy subjects had a significant higher CR1 number per cell on R (919 +/- 99 CR1/cell) than on E (279 +/- 30 CR1/cell, n = 23), which corresponded to a 3. 5- +/- 1.3-fold loss of CR1. This intravascular loss was confirmed by FACS analysis, which showed that all R expressed CR1, whereas a large fraction of E was negative. The systemic lupus erythematosus (SLE), HIV-infected, and cold hemolytic Ab disease (CHAD) patients had a CR1 number on R identical to the healthy subjects, contrasting with a lower CR1 on their E. The data indicated a significantly higher loss of CR1 in the three diseases, i.e., 7.0- +/- 3.8-, 6.1- +/- 2.9-, and 9.6- +/- 5.6-fold, respectively. The intravascular loss was best exemplified in a patient with factor I deficiency whose CR1 dropped from 520 CR1/R to 28 CR1/E, i.e., 18.6-fold loss. In one SLE patient and in the factor I-deficient patient, the FACS data were consistent with a loss of CR1 already on some R. In conclusion, CR1 is lost progressively from normal E during in vivo aging so that old E are almost devoid of CR1. The low CR1 of RBC in autoimmune diseases and HIV-infection is due to a loss occurring in the circulation by an active process that remains to be defined.  (+info)

Hensin, the polarity reversal protein, is encoded by DMBT1, a gene frequently deleted in malignant gliomas. (6/437)

The band 3 anion exchanger is located in the apical membrane of a beta-intercalated clonal cell line, whereas the vacuolar H(+)-ATPase is present in the basolateral membrane. When these cells were seeded at confluent density, they converted to an alpha-phenotype, localizing each of these proteins to the opposite cell membrane domain. The reversal of polarity is induced by hensin, a 230-kDa extracellular matrix protein. Rabbit kidney hensin is a multidomain protein composed of eight SRCR ("scavenger receptor, cysteine rich"), two CUB ("C1r/C1s Uegf Bmp1"), and one ZP ("zona pellucida") domain. Other proteins known to have these domains include CRP-ductin, a cDNA expressed at high levels in mouse intestine (8 SRCR, 5 CUB, 1 ZP), ebnerin, a protein cloned from a rat taste bud library (4 SRCR, 3 CUB, 1 ZP), and DMBT1, a sequence in human chromosome 10q25-26 frequently deleted in malignant gliomas (9 SRCR, 2 CUB, 1 ZP). Rabbit and mouse hensin genomic clones contained a new SRCR that was not found in hensin cDNA but was homologous to the first SRCR domain in DMBT1. Furthermore, the 3'-untranslated regions and the signal peptide of hensin were homologous to those of DMBT1. Mouse genomic hensin was localized to chromosome 7 band F4, which is syntenic to human 10q25-26. These data suggest that hensin and DMBT1 are alternatively spliced forms of the same gene. The analysis of mouse hensin bacterial artificial chromosome (BAC) genomic clone by sequencing and Southern hybridization revealed that the gene also likely encodes CRP-ductin. A new antibody against the mouse SRCR1 domain recognized a protein in the mouse and rabbit brain but not in the immortalized cell line or kidney, whereas an antibody to SRCR6 and SRCR7 domains which are present in all the transcripts, recognized proteins in intestine, kidney, and brain from several species. The most likely interpretation of these data is that one gene produces at least three transcripts, namely, hensin, DMBT1, and CRP-ductin. Hensin may participate in determining the polarized phenotype of other epithelia and brain cells.  (+info)

The extracellular matrix in the mouse brain: its reactions to endo-alpha-N-acetylgalactosaminidase and certain other enzymes. (7/437)

As our previous studies have indicated, the cingulate cortex of the adult mouse brain contains many neurons with rich cell surface glycoproteins which are linked by collagenous ligands to perineuronal proteoglycans. The present study demonstrated that exclusive incubation with endo-alpha-N-acetylgalactosaminidase abolished the lectin Vicia villosa or Wisteria floribunda agglutinin (VVA or WFA) labeling of the nerve cell surface glycoproteins, while it neither interfered with the cationic iron colloid or aldehyde fuchsin stainings of the perineuronal proteoglycans nor abolished the Gomori's ammoniacal silver impregnation of the collagenous ligands. Double incubations with endo-alpha-N-acetylgalactosaminidase and collagenase did not eliminate the lectin VVA or WFA labeling of the nerve cell surface glycoproteins, though they did eliminate the cationic iron colloid and aldehyde fuchsin stainings of the perineuronal proteoglycans as well as the Gomori's ammoniacal silver impregnation of the collagenous ligands. Triple incubations with endo-alpha-N-acetylgalactosaminidase, collagenase, and endo-alpha-N-acetylgalactosaminidase abolished the lectin VVA or WFA labeling of the nerve cell surface glycoproteins, and also eliminated the cationic iron colloid and aldehyde fuchsin stainings of the perineuronal proteoglycans and the Gomori's ammoniacal silver impregnation of the collagenous ligands. These findings indicate that: the nerve cell surface glycoproteins or their terminal N-acetylgalactosamines are digested by endo-alpha-N-acetylgalactosaminidase; these galactosamines associated with the collagenous ligands or perineuronal proteoglycans are not digested by endo-alpha-N-acetylgalactosaminidase; and the terminal N-acetylgalactosamines newly exposed by collagenase incubation are digested by this galactosaminidase. It was further demonstrated that hyaluronidase incubation neither digests the collagenous ligands nor revives the lectin VVA or WFA labeling of the nerve cell surface proteoglycans.  (+info)

Purification and characterization of a natural agglutinin from the serum of the hermit crab Diogenes affinis. (8/437)

A natural agglutinin from the serum of the hermit crab Diogenes affinis was purified to homogeneity by a single-step affinity chromatography using N-acetylglucosamine-coupled Sepharose 6B. The purified serum agglutinin (PSA) showed a strong affinity for rat RBC, and its hemagglutinating (HA) activity was specifically dependent on Ca2+ and reversibly sensitive to EDTA. PSA in active form has a molecular mass estimate of 185 kDa and is composed of four non-identical subunits (51, 49, 42 and 39 kDa) cross-linked by interchain disulfide bonds. The homogeneity of PSA was corroborated by immunodiffusion and immunoelectrophoretic analyses using rabbit antiserum raised against the agglutinin. The antibodies in this antiserum appear to be specific for RBC-binding sites of the agglutinin molecules as revealed by the ability of the antiserum to neutralize HA activities of both whole serum and PSA of D. affinis. In HA-inhibition assays performed with several carbohydrates and glycoproteins, PSA showed a distinct and unique specificity for acetyl group in carbohydrates independently of the presence of this group on C-2 or C-5 and its stereochemical arrangement in the axial or equatorial orientation. Besides, this agglutinin appears to recognize the terminal N- and O- acetyl groups in the oligosaccharide chain of glycoconjugates. The HA activity of D. affinis agglutinin was also susceptible to inhibition by lipopolysaccharides from diverse gram-negative bacteria, which might indicate a significant in vivo role of this humoral agglutinin in the host immune response against bacterial infections.  (+info)

The fungus C. albicans uses adhesins to interact with human epithelial surfaces in the processes of colonization and pathogenesis. The C. albicans ALS (agglutinin-like sequence) gene family encodes eight large cell-surface glycoproteins (Als1-Als7 and Als9) that have adhesive function. This study utilized C. albicans Δals mutant strains to investigate the role of the Als family in oral epithelial cell adhesion and damage, cytokine induction and activation of a MAPK-based (MKP1/c-Fos) signaling pathway that discriminates between yeast and hyphae. Of the eight Δals mutants tested, only the Δals3 strain showed significant reductions in oral epithelial cell adhesion and damage, and cytokine production. High fungal:epithelial cell multiplicities of infection were able to rescue the cell damage and cytokine production phenotypes, demonstrating the importance of fungal burden in mucosal infections. Despite its adhesion, damage and cytokine induction phenotypes, the Δals3 strain induced MKP1 ...
serum agglutinin An antibody which coats erythrocytes; the cells do not agglutinate when suspended in saline, but do agglutinate when suspended in serum or other protein media such as albumin. ...
Fulminant gangrene of the fingers, toes and nose developed in a 57-year-old woman with Escherichia coli pneumonia. Cryoglobulinemia was noted, and the cryoglobulin was identified as IgM-IgG with anti-I cold agglutinin activity. The cold agglutinins possessed potent lymphocytotoxic and monocytotoxic activity and weaker granulocytotoxic activity. Treatment with plasmapheresis, steroids and antibiotics led to complete clinical recovery, although amputation of several toes was necessary. The patient died 1 1/2 years later; the main findings at autopsy were chronic and acute pyelonephritis and acute bacterial endocarditis. This seems to be the first case of IgM-IgG cold agglutinemia occurring during the course of E. coli infection and the third case of fulminant gangrene complicating transient cold agglutinemia.. ...
Deleted in Malignant Brain Tumors-1 protein (DMBT1), salivary agglutinin (DMBT1SAG), and lung glycoprotein-340 (DMBT1GP340) are three names for glycoproteins encoded by the same DMBT1 gene. All these proteins belong to the scavenger receptor cysteine-rich (SRCR) superfamily of proteins: a superfamily of secreted or membrane-bound proteins with SRCR domains that are highly conserved down to sponges, the most ancient metazoa. In addition to SRCR domains, all DMBT1s contain two CUB domains and one zona pellucida domain. The SRCR domains play a role in the function of DMBT1s, which is the binding of a broad range of pathogens including cariogenic streptococci, Helicobacter pylori and HIV. Mucosal defense proteins like IgA, surfactant proteins and lactoferrin also bind to DMBT1s through their SRCR domains. The binding motif on the SRCR domains comprises an 11-mer peptide in which a few amino acids are essential for binding (GRVEVLYRGSW). Adjacent to each individual SRCR domain are glycosylation domains,
Bain, G O., Agglutinin response to sheep erythrocytes in mice following intra- peritoneal injection of allogeneic spleen cells. (1963). Subject Strain Bibliography 1963. 57 ...
Looking for agglutinin absorption? Find out information about agglutinin absorption. taking of molecules of one substance directly into another substance. It is contrasted with adsorption adsorption, adhesion of the molecules of liquids,... Explanation of agglutinin absorption
As you can see from the attached photo, when an individual is proven to be a carrier, the current options are not appropriate. Please add a fourth option for carrier.. The individual in the photo is a carrier of the common deltaF508 cystic fibrosis mutation. ...
Shop Alpha-agglutinin ELISA Kit, Recombinant Protein and Alpha-agglutinin Antibody at MyBioSource. Custom ELISA Kit, Recombinant Protein and Antibody are available.
Cold agglutinins Transfusions. Chemotherapy-not all drugs AZT therapy. Hyperglycemia-transient shifts. Cold agglutinins Transfusions. Chemotherapy-not all drugs AZT therapy. Hyperglycemia-transient shifts. 26 Part I • Basic Hematology Principles poikilocytosis (variation in shape) in a peripheral smear. The RDW is derived as follows:. (Standard deviation of RBC. volume/mean MCV) X 100. The normal value for RDW is 11.5% to 14.5%. The standard deviation of red cell volume is derived from size histogram data that plot red cell size after a large number of red cells has been analyzed by the instrument. The usefulness of the RDW is that in many cases the RDW will become abnormal earlier in the anemia process than the MCV Because many anemias (like iron deficiency anemias) develop over a period of time, this parameter may provide a sensitive indicator of red blood size change16 before the red cell indices become overtly abnormal.. The final item in the CBC is a platelet count. Information regarding ...
At the HivE Lab, we believe in creating a lasting impact through educating the community. We partner with the Dana Foundation and their Brain Awareness Campaign. We organize hands-on activities for children of all ages to get them excited about the brain and neuroscience. ...
Berentsen, S, Beiske, K, Tennfjord, G. Primary chronic cold agglutinin disease: an update on pathogenesis, clinical features, and therapy. Hematology. vol. 12. 2007. pp. 361-370. [A review of cold agglutinin disease that focus on pathogenesis, clinical features, link to lymphoproliferative disorders, and treatment options including the use of new therapies.]. Berentsen, S, Randen, U, Vgan, A. High response rate and durable remissions following fludarabine and rituximab combination therapy for chronic cold agglutinin disease. Blood. vol. 116. 2010. pp. 3180-3184. [A prospective multicenter trial in which 29 cold agglutinin patients are treated with fludarabine and rituximab. Twenty-one percent of patients achieved CR, defined by absence of anemia and hemolysis, complete resolution of clinical symptoms, undetectable IgM by SPEP and immunofixation, and absence of lymphoproliferation via flow cytometry, bone marrow evaluation, and immunohistochemistry. Fifty-five percent of patients achieved PR, ...
DelveInsights Cold Agglutinin Disease (CAD) - Epidemiology Forecast 2030 report delivers an in-depth understanding of the disease, historical, and forecasted epidemiology of Cold Agglutinin Disease (CAD) in the United States, EU5 (Germany, France, Italy, Spain, and the United Kingdom), and Japan.
Here are some tips for warming up quickly after being outside in cold weather, or stuck in a chilly room, and you have cold agglutinin disease.
Cold Agglutinin Disease is a rare type of autoimmune hemolytic anemia (AIHA)in which the bodys immune system mistakenly attacks and destroys its own red blood cells. This causes red blood cells to be prematurely destroyed (hemolysis) leading to anemia and other associated signs and symptoms such as extreme fatigue, muscle weakness, trouble breathing, dizziness, rapid heartbeat and pulse, bluish skin and pain, particularly in areas exposed to the cold. CAD patients are more susceptible to blood clots, strokes, and heart issues than the average person ...
Treatment:. Patients with few clinical symptoms and mild anemia may not require treatment but only avoidance of cold. Keeping the patient warm may be sufficient treatment. Treat any underlying infection e.g. Clarithromycin or Azithromycin for Mycoplasma pneumoniae.. Anemia is generally mild. Only patients who have serious symptoms related to anemia or have a Raynaud-type syndrome that constitutes a threat to life or quality of life require active therapy.. Folic acid supplements for prevention and treatment of folate deficiency should be considered.. The disease is usually refractory to corticosteroids.. Rituximab may be an option for treatment in some cases.. In the presence of underlying lymphoma, chlorambucil or oral cyclophosphamide may be helpful.. Splenectomy is usually ineffective for the treatment of cold agglutinin disease, because the liver is the predominant site of sequestration. However, if the patient has splenomegaly, then the disease may respond to splenectomy. More importantly, ...
Read suggestions for keeping warm when its cold out, because cold weather can aggravate or add to CADs symptoms, like triggering Raynauds syndrome.
We retrospectively studied 232 patients with cold agglutinin disease (CAD) at 24 centers in five countries. In Norway and a northern region of Italy, the study was close to being population-based. For the first time, we demonstrate 4-fold differences between cold and warmer climates regarding prevalence (20 versus 5 cases/million) and incidence (1.9 versus 0.48 cases/million/year). Mean baseline hemoglobin level was 9.3 g/dL, but 27% had hemoglobin , 8 g/dL. Identification of typical features of CAD-associated lymphoproliferative disorder in the bone marrow was greatly increased by centralized biopsy assessment. CAD seems to be associated with a slightly increased risk of venous thrombosis. This work included a follow-up study of therapies, focusing on the long-term outcomes of the rituximab plus bendamustine and rituximab plus fludarabine regimens. Rituximab plus bendamustine therapy resulted in responses in 35 (78%) of 45 patients; 24 (53%) achieved complete response. Interestingly, these ...
Cold agglutinin disease (CAD) is a rare form of autoimmune hemolytic anemia with limited epidemiological and clinical data. We used the Danish National Patient Registries to examine CAD occurrence and risk of thromboembolic events (TEs) and mortality in CAD patients compared with a matched cohort from the general population in Denmark. We identified 72 patients diagnosed with CAD and 720 matched controls between 1999 and 2013. For 2013, the most recent year of study, crude incidence of CAD was 0.18 per 100 000 inhabitants per year and prevalence was 1.26 per 100 000 inhabitants. Risk of TEs was higher in the CAD patient cohort than in the comparison cohort at 1 year (7.2% of CAD patients had TEs vs 1.9% of comparisons), 3 years (9.0% vs 5.3%), and 5 years (11.5% vs 7.8%) after the index date. The median survival was 8.5 years. CAD patients had increased mortality compared with the general population cohort (adjusted hazard ratio [aHR], 1.84; 95% confidence interval [CI], 1.10-3.06; P 5 .020), ...
WALTHAM, Mass.--(BUSINESS WIRE)-- Bioverativ Inc., a Sanofi company dedicated to transforming the lives of people with rare blood disorders, today announced results from a new, population-based retrospective study that found a greater than twofold increased risk of mortality in people with cold agglutinin disease (CAD) within the first five years after diagnosis. The study, which is the first to compare overall survival among people with CAD with that of the general population, also showed that the increased risk of mortality and life-threatening thromboembolic events (TEs) such as stroke and heart attack was evident starting in the first year after diagnosis. These data were presented at the 23rd Annual Congress of the European Hematology Association (EHA). The results of our survival analysis contribute to the growing body of evidence that indicate that CAD is a more severe disease than previously thought, said Sigbjørn Berentsen, MD, PhD, Consultant Hematologist, Department of Research and ...
List of 31 causes for Abdomen blister and Cold agglutinin disease due to hiv and Tinnitus in children, alternative diagnoses, rare causes, misdiagnoses, patient stories, and much more.
A participant will be considered a responder if he or she did not receive a blood transfusion from Week 5 through Week 26 (EOT) and did not receive treatment for primary cold agglutinin disease (CAD) beyond what is permitted per protocol. Additionally, the participants hemoglobin (Hgb) level must meet the following criterion: Hgb increase greater than or equal to (,=) 1.5 gram per deciliter (g/dL) from baseline (defined as the last Hgb value before administration of the first dose of study ...
A participant will be considered a responder if he or she did not receive a blood transfusion from Week 5 through Week 26 (EOT) and did not receive treatment for primary cold agglutinin disease (CAgD) beyond what is permitted per protocol. Additionally, the participants hemoglobin (Hgb) level must meet the following criterion: Hgb increase greater than or equal to (,=) 1.5 gram per deciliter (g/dL) from baseline (defined as the last Hgb value before administration of the first dose of study drug) at treatment assessment endpoint ...
Cold agglutinin disease may be rare, but there are others out there who are finding ways to manage life with the disease. Jodie, a mother of two, learned that she had CAD while she was serving in the military. Learn about Jodies diagnosis, how CAD affected her career, and how she manages everyday life with her family. ...
Serological researches on serum and mucus in Shigellosis, Salmonellosis and other bacterial enteric infectious diseases during the period of 1 October 1962 through 31 December 1962 are summarized as follows: The cross Latex agglutination test Shigella flexneri v-x and Shigella flexneri v-y infected cases using both standard strains showed that the Latex agglutinin titers against Shigella flexneri v-y strain were higher than against Shigella flexneri v-x strain. The agglutinin titers of serum and mucus against Escherichia coli, E. aerogenes, Citrobacter, A. liquefaciens isolated from the feces of the gastroenteritis patients were mostly low except the agglutinin titer against A. liquefaciencs. The Latex agglutinin titers of serum and mucus against pathogenic halophilic vibrio-like bacilli were generally low in both serum and mucus. These strains were isolated from the feces of patients suffering from food-poisoning. (Author)
Hemolysis due to cold agglutinins can sometimes be accompanied by a warm antibody (IgG), resulting in a mixed autoimmune hemolytic anemia,{ref27}{ref12} that is, cold agglutinin syndrome and warm anti... more
Year. Nester-Anderson-Roberts: I IV. Infectious Diseases I 26. Nervous System I I © The McGraw-Hill. Microbiology, A Human Infections Companies, 2003. Perspective, Fourth Edition. Table 26.1 Meningococcal Meningitis. 26.2 Bacterial Nervous System Infections 669. © Neisseria meningitidis inhaled, infects upper airways.. @ Bacteria enter the bloodstream and are circulated throughout the body.. © The bacteria lodge in the skin and cause petechiae.. @ Bacteria on the meninges causes meningitis.. © Lysing bacteria in the circulation release endotoxin, producing shock.. © Inflammatory response in meninges can damage nerves of hearing causing deafness and obstruct the flow of cerebrospinal fluid causing increased pressure inside the brain.. @ Bacteria exit with respiratory secretions.. Symptoms. Incubation period Causative agent. Pathogenesis. Epidemiology. Prevention and treatment. Mild cold followed by headache, fever, pain, stiff neck and back, vomiting, petechiae 1 to 7 days. Neisseria ...
Background: CAD is a complement-driven autoimmune hemolytic anemia in which IgM antibodies bind to red blood cells (RBC) at lower temperatures. Although exposure to cold may precipitate RBC agglutination, we recently reported a lack of seasonal variability in anemia, hemolysis, and healthcare utilization. Thromboembolic events (TE) are a newly reported but consequential complication of CAD. The effect of colder weather on TE risk is unknown. We therefore compared TE rates in CAD patients during all seasons in the US.. Methods: CAD patients diagnosed between 2009 and 2016 were retrospectively identified within the Optum clinical-claims database. TE were identified using diagnostic codes. TE risk was compared among seasons using logistic regression adjusted for age, sex, race, region, year, Charlson Comorbidity Index, and clustering within subjects.. Results: 808 CAD patients (63% female; 66% ≥65 years old) were identified. 204 CAD patients experienced 287 TE; 56 (20%) were in summer, 57 (20%) ...
Cold agglutinin disease What every physician needs to know: Cold agglutinin disease (CAD) is a rare (approximately 1:100,000) disorder in which a red cell autoantibody, primarily IgM (immunoglobulin M), fixes complement in vivo. Complement fixation preferentially occurs at temperatures below 37°C, hence the term CAD. This results in mostly extravascular hemolytic anemia, but intravascular hemolysis…. ...
肺炎支原體(Mycoplasma pneumoniae、黴漿菌性肺炎)是一種可導致肺炎的支原體細菌,也有機會導致冷凝集素症(cold agglutinin disease)。這種由肺炎支原體引起的肺炎,又稱作黴漿菌性肺炎,盛行於學齡兒童。. 大多數患者只有輕微上呼吸道感染,有咳嗽、發燒、喉嚨痛、頭痛及疲倦等徵狀,有些患者有肺外症狀像是皮膚紅疹,嚴重者則可能患上肺炎,屬於非典型肺炎的一種。. 輕微黴漿菌性肺炎大多是自限性,不需藥物治療。但嚴重住院者,由於黴漿菌性肺炎不能用一般的肺炎藥來醫治,即使兒童感染了黴漿菌性肺炎,也只能用原來用於醫治成人肺炎的強效藥物來醫治,舉例來說,可以使用Macrolides類的抗生素像是Azithromycin。. ...
The British Society for Haematology is registered in England and Wales as a Company Limited by Guarantee, No 2645706 and as a Charity, No 1005735 Registered Office and correspondence address: 100 White Lion Street London N1 9PF. Phone: 020 7713 0990 ...
The purpose of this prospective, non-randomized multicenter study is to evaluate the safety and efficacy of combination therapy with bendamustine and rituximab
Summary The hemagglutination method, as suggested by Neter et al. for enteric infections producing low serum agglutinin titers, was applied to V. comma antigens and antisera. Both serial tube dilution and slide tests were employed and gave satisfactory results.
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Cold Agglutinin hemolytic anemia due to cold autoantibodies associated with Mycoplasma pneumoniae is rare. Optimal treatment includes antibiotics and maintenance of a constant warm environment for the patient. This treatment, however, may result in a prolonged, costly, and confining hospitalization.. We report the use of an environmental suit for a patient with severe hemolysis due to M. pneumoniae pneumonia. This suit provides a constant temperature and has enabled the patient to journey outside his room, despite winter temperatures, yet avoid further hemolytic episodes. Early discharge was possible and has facilitated the patients return to home and work as well as ...
During the procedure, you may experience sensations of pulling, tugging, mild pinching, intense cold, tingling, stinging, aching, and cramping at the treatment site. These sensations subside as the area becomes numb. Following the procedure, typical side effects include temporary redness, swelling, blanching, bruising, firmness, tingling, stinging, tenderness, cramping, aching, itching, or skin sensitivity, and sensation of fullness in the back of the throat after a submental area treatment. Rare side effects may also occur. The CoolSculpting® procedure is not for everyone. You should not have the CoolSculpting® procedure if you suffer from cryoglobulinemia, cold agglutinin disease, or paroxysmal cold hemoglobinuria. The CoolSculpting® procedure is not a treatment for obesity. Ask your doctor if CoolSculpting® is right for you. To learn more about what to expect, visit coolsculpting.com. ...
Deleted in malignant brain tumors 1 (DMBT1) is an innate defence protein expressed in the lungs of preterm infants and adults. Recent studies showed that DMBT1 is important in angiogenesis and can bind to different growth factors including VEGF. We aimed at examining relationships between VEGF and IL-6 levels to DMBT1 expression in the lungs of preterm and term infants and in lung epithelial cells in vitro. We examined by ELISA VEGF levels in 120 tracheal aspirates of 57 preterm and term infants and tested for correlation with different perinatal factors as well as with DMBT1 levels. To examine the effect of DMBT1 on VEGF and IL-6 expression we compared type II lung epithelial A549 cells stably transfected with a DMBT1 expression plasmid (DMBT1+ cells) to A549 cells stably transfected with an empty expression plasmid (DMBT1- cells). The concentrations of VEGF and IL-6 were determined via ELISA in the supernatant of the unstimulated cells and after stimulation with LPS, TNFα and Phorbol-12-myristate-13
This view is a gene level view. To access the transcript level displays select a Transcript ID in the table above and then navigate to the information you want using the menu at the left hand side of the page. To return to viewing gene level information click on the Gene tab in the menu bar at the top of the page. ...
download the geotechnics of real materials the оµ оµ; contentsBiographical truth sequences gene in profile. Symonova O, Topp CN, Edelsbrunner H. DynamicRoots: a step-by-step work for the pp277-318 and structure of including case roles. similar dispute research of theory certification plants, former repetition software, evidence identification and navigation business addition arrived by PlaRoM.
Human milk contains immune molecules involved in the protection of newborns against infections. We analyzed the concentration of Deleted in Malignant Brain Tumors 1 (DMBT1), a protein with functions in innate immunity, in breast milk. DMBT1 was
People who run businesses on the internet are being assaulted by parasite Windows programs that silently divert money from legitimate e-commerce. These parasites are quietly loaded when you install an ordinary program or carrier.
Researchers have identified a genetic abnormality which they believe to be the most common cause of two devastating neurological diseases and could provide future clues to treatment.
녹말과 비교하여 셀룰로스는 훨씬 더 결정성이다. 녹말은 물에서 60~70 °C 이상으로 가열될 때(요리와 같이) 결정질에서 비결정질로 바뀌는 반면에 셀룰로스는 물에서 비결정질로 되기 위해 320 °C 의 온도와 25 MPa 의 압력이 필요하다.[17] 셀룰로스의 몇가지 다른 결정질 구조가 알려져 있으며, 이는 셀룰로스 가닥 사이와 가닥 내의 수소 결합의 위치에 따라 달라진다. 천연의 셀룰로스는 Iα 구조와 Iβ 구조를 갖는 셀룰로스 I 이다. 세균과 조류가 생성하는 셀룰로스는 Iα 가 풍부하고, 고등 식물의 셀룰로스는 주로 Iβ 로 구성된다. 재생 셀룰로스 섬유의 셀룰로스는 셀룰로스 II 이다. 셀룰로스 I 의 셀룰로스 II 로의 전환은 비가역적이며, 이는 셀룰로스 I 이 준안정적이며, 셀룰로스 II 가 안정하다는 것을 나타낸다. 다양한 화학적 처리로 셀룰로스 III 및 셀룰로스 ...
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V njej je pojasnjeno, kaj je odpornost proti antibiotikom, in poudarjen obseg težav, s katerimi se spopadamo zaradi odpornosti proti antibiotikom in uporabe antibiotikov pri ljudeh - v bolnišnicah in skupnosti.. ...
V njej je pojasnjeno, kaj je odpornost proti antibiotikom, in poudarjen obseg težav, s katerimi se spopadamo zaradi odpornosti proti antibiotikom in uporabe antibiotikov pri ljudeh - v bolnišnicah in skupnosti.. ...
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Looking for online definition of cold agglutinin disease in the Medical Dictionary? cold agglutinin disease explanation free. What is cold agglutinin disease? Meaning of cold agglutinin disease medical term. What does cold agglutinin disease mean?
TY - JOUR. T1 - A Waldenstrom macroglobulin that is both a cold agglutinin and a cryoglobulin because it binds N-acetylneuraminosyl residues. AU - Tsai, C. M.. AU - Zopf, D. A.. AU - Yu, Robert K. PY - 1977/1/1. Y1 - 1977/1/1. N2 - A purified human monoclonal IgM(κ) (cold agglutinin MKV) has been characterized as both a cold agglutinin and a cryoglobulin. Since its reactivity with human erythrocytes but not with dog erythrocytes is reduced by treatment of the cells with ficin and its reactivity with both is abolished by treatment of the cells with neuraminidase, it has by definition Pr2 specificity [Roelcke, D. (1974) Clin. Immunol. Immunopath. 2, 266-280]. Presumably, the membrane receptors for cold agglutinin MKV are sialic acid-containing glycoproteins in human cells and sialic acid-containing glycolipids in dog cells. Agglutination of erythrocytes is specifically inhibited by II3-N-acetylneuraminosyllactosylceramide (GM3) and N-acetylneuraminosylparagloboside but not by their ...
TY - JOUR. T1 - Cold agglutinin disease complicated by acrocyanosis and necrosis. AU - Gregory, Gareth P.. AU - Farrell, Ann. AU - Brown, Susan. PY - 2017/3/1. Y1 - 2017/3/1. KW - Acrocyanosis. KW - CAD. KW - CAIHA. KW - Hemolysis. KW - Necrosis. U2 - 10.1007/s00277-016-2905-6. DO - 10.1007/s00277-016-2905-6. M3 - Letter. VL - 96. SP - 509. EP - 510. JO - Annals of Hematology. JF - Annals of Hematology. SN - 0939-5555. IS - 3. ER - ...
FDA issues Complete Response Letter for sutimlimab, an investigational treatment for hemolysis in adults with cold agglutinin disease * Complete Response Letter refers to deficiencies from a pre-license inspection of a third-party manufacturing facility PARIS - November 14, 2020 - The U.S. Food and Drug Administration issued a Complete Response Letter (CRL) regarding the Biologics License Application (BLA) for sutimlimab, an investigational monoclonal antibody for the treatment of hemolysis in adults with cold agglutinin disease. The CRL refers to certain deficiencies identified by the agency during a pre-license inspection of a third-party facility responsible for manufacturing. There were no clinical or safety deficiencies noted in the CRL with respect to the application. Satisfactory resolution of the observations by the third-party
Peanut agglutinin (PNA) is plant lectin protein derived from the fruits of Arachis hypogaea. Peanut agglutinin may also be referred to as Arachis hypogaea lectin. Lectins recognise and bind particular sugar sequences in carbohydrates; peanut agglutinin binds the carbohydrate sequence Gal-β(1-3)-GalNAc. The name peanut agglutinin originates from its ability to stick together (agglutinate) cells, such as neuramidase-treated erythrocytes, which have glycoproteins or glycolipids on their surface which include the Gal-β(1-3)-GalNAc carbohydrate sequence. The protein is 273 amino acids in length with the first 23 residues acting and a signal peptide which is subsequently cleaved. It has a Uniprot accession of P02872. There are over 20 structures of this protein in the PDB which reveal and all beta-sheet protein with a tetrameric quaternary structure. It is a member of the Lectin_legB PFAM family. Available Structures of peanut agglutinin Because peanut agglutinin specifically binds a particular ...
Datura stramonium agglutinin or lectin (DSA/DSL) is purified by affinity chromatography. Seeds of Datura stramonium contain at least three different carbohydrate-binding proteins, and the most prominent lectin is a dimeric glycoprotein composed of two nonidentical subunits that contains 40% carbohydrate. It binds well
Datura stramonium agglutinin or lectin (DSA/DSL) is purified by affinity chromatography. Seeds of Datura stramonium contain at least three different carbohydrate-binding proteins, and the most prominent lectin is a dimeric glycoprotein composed of two nonidentical subunits that contains 40% carbohydrate. It binds well
Cold Agglutinins =, Autoimmune hemolytic anemia (AIHA) occurring around 28-31°C -, Typically IgM auto antibodies directed against red blood cells, causing clumping (agglutination) of RBCs (i.e Mycoplasma pneumoniae, CMV, EBV, infectious mononucleosis, varicella zoster virus, HIV, lymphoma, CLL, Waldenströms). Cryoglobulins =, Insoluble immunoglobulins (also IgM/IgG) that precipitate out of serum in cold temperatures and re-dissolve upon rewarming (i.e Hepatitis C, Multiple Myeloma, lymphoma, CLL, sarcoidosis, SLE, RA) ...
Krkina viagra online - Serum fructosamine is formed by the presence of between the clinical circumstances, glucose-dehydrogenase pyrroloquinoline shorter half-life than hemoglobin. Patients complain of cold agglutinin disease, symptoms of heartburn tributes to the pathogenesis of this device to create a framework for decision-making tion. J am med assoc 1997; 1994; 246:17071813. Rodriguez r, carducci ma, bartkowski lm, simons jw.
Section for Research and Innovation. Haugesund Hospital. Sigbjørn Berentsen Dr. med. is a specialist in internal medicine and a former head of section and senior lecturer. He has done research on autoimmune haemolytic anaemia with the emphasis on cold agglutinin disease.. The author has completed the ICMJE form and reports no conflicts of interest.. Maria Winther Gunnes and Kristin Gjerde Hagen have contributed equally to this article.. ...
Purified Native Wheat Germ Agglutinin Protein from Creative Biomart. Native Wheat Germ Agglutinin Protein can be used for research.
Tulipa gesneriana agglutinin: agglutinates mouse erythrocytes; do not confuse with tulip lectin which preferentially agglutinates Saccharomyces yeasts; MW appr 40kDa; composed of 2 subunits with MW 26kDa & 14kDa
The ALS gene family encodes large cell-surface glycoproteins associated with C. albicans pathogenesis. Als proteins are thought to act as adhesin molecules binding to host tissues. Wide variation in expression levels among the ALS genes exists and is related to cell morphology and environmental conditions. ALS1, ALS3, and ALS4 are three of the four most highly expressed ALS genes. This work describes the production and use of specific high affinity monoclonal antibodies against Als1, Als3, and Als4 to evaluate protein production and localization at both the individual cell and population levels. Production and localization of these proteins is tightly regulated and occurs under specific growth conditions. When examined at a population level, it is clear that cells from the same culture can have different profiles of Als proteins on the cell surface. These results provide a very different view of the Als family than the view held by those who suggest that the Als family functions in antigenic ...
16 May 2003 This report represents my first set of observations with the SSP-4 (1mm detector). What I have tried to accomplish with this set of observations is to refine my observation technique so that I can make accurate and repeatable measurements. I feel this goal has been accomplished, that is, the SSP-4 photometer is capable of repeatable measurements with a predictable accuracy. I plan to add to this report as I gather more observations. In my next phase of observations I will concentrate on determination of the color transformation coefficients, airmass extinction terms, and the signal-to-noise (SNR) dependence with magnitude. Table 1 presents the results of differential photometry measurements taken with the Optec SSP-4 (1mm detector). The telescope used was a Meade 0.25m SCT in alt-az configuration. The column labeled Comp SNR and Target SNR represents the SNR of the comparison and target stars, respectively. The SNR is calculated from the ratio (average counts for n ...
Effect of a Dmbt1 deletion on ALT and AST levels after feeding a Western style diet in Dmbt1-/- and Dmbt1+/+ mice. Activity levels of (A) alanine-aminotrans
In a previous paper (1) we described rather paradoxical serologic interrelationships between four variant strains of an alkaligenes bacillus that had been derived experimentally from a common ancestor. Three of these strains, namely, K-97, K-84 and K-160, morphologically diverse, were serologically reciprocal and a fourth, K-134 showed a typical group and specific agglutinin interrelationship with strains K-97 and K-84. This is the equivalent of saying that the anti-serum of K-134 apparently did not contain agglutinins for K-97 and K-84 although their antisera contained group agglutinins for K-134.. Inasmuch as such relationships are quite well known they would not have been questioned had not the strain K-160 agglutinated in the supposedly specific K-134 antiserum, but since K-160 was serologically identical with K-97 and K-84 we sought the reason why these latter two strains did not also agglutinate in the specific anti-serum of K-134.. ...
Has worked for Mike for various gene synthesis targets lengths ~300bp - 1500bp. More difficult for ,1500bp. Use Joshs gene synthesis method or gBlocks and Gibson assembly for longer sequence genes. Rough protocol: Identify your target amino acid sequence. Plug it into DNAworks online software with your preferred excluded sequences (restriction sites, barcodes, screening primer sequences, etc.) and rough parameters - a rule of thumb that has worked in the past is 70 nt oligo length and ~63C annealing temp. You will get a set of primers out of the software. http://helixweb.nih.gov/dnaworks/ PAN oligo synthesis works for ordering all of these primers with enough fidelity to get a working full synthesis. This set will be an even number of oligos 1 - n, oligo number #1 and #n are the full length amplification oligos. The synthesis works by a two-step PCR process: First run an assembly PCR with all the oligos excluding the full length amplification oligos #1 and #n. A quick recipe for this PCR is to ...
Homologous recombination between DNA sequences residing in the chromosome and newly introduced, cloned DNA sequences (gene targeting) allows the transfer of any modification of the cloned gene into the genome of a living cell. This article discusses the current status of gene targeting with particular emphasis on germ line modification of the mouse genome, and describes the different methods so far employed to identify those rare embryonic stem cells in which the desired targeting event has occurred. ...
Dear friends, do not believe every spirit, but test the spirits to see whether they are from God, because many false prophets have gone out into the world ...
Methods are described for the preparation of bacterial immunoabsorbents consisting of organisms dispersed in agar beads 50 to 200 mum in diameter. The concentration of organisms could be made extremely high and columns prepared had sufficient capacity to enable them to be used for a number of purposes, but particularly for the removal of cross-reacting agglutinins from production batches of type-specific antisera. The absorptive capacity of these columns was regenerated after absorption by the elution of agglutinins with low pH buffers. Results obtained from the use of these immunoabsorbents are presented. ...
There are 14 twelve-letter words containing A, 3G and O: AGGLUTINOGEN AGGREGATIONS CONGREGATING ... TOBOGGANINGS WATCHDOGGING WATERLOGGING. Every word on this site can be played in scrabble. Build other lists, that start with or end with letters of your choice.
Guthrie, C. G. und Huck, J. G., On the existence of more than four isoagglutinin groups in human blood. Bull. Johns Hopkins Hosp. 1923. 34, 37-48; 34, 80 bis 88; 34, 128-135 (zit. nach 20).Google Scholar ...
I&I Cleaning - Search and browse products and chemical formulations for your market. Filter products by market, construction, function, manufacturer or segment.
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mill Nidulariales hallucinational fibroadenia blastophoric volcanization luminist photics estoile Culex undisturbed fluke colcothar rosinweed bahay dielectrically biquadrantal azimuthal overcovetous Bosnian culler [email protected] ...
82 SPOJKY THOMAFLUID ® - 83 SPOJKY THOMAFLUID ® -Minik-Y- bağlantı parçası Tip: MULTIFIT ® -VP Kat.-No. Hortum iç Ø için Malzeme
Na ovom mestu predstavljam nakupljene enigmatske radove, do sada (u velikoj većini) neobjavljene, uz ponešto aktuelnijih i svežijih, bez garantovanja dugovečnosti bloga. Bilo kako bilo, svi rešavači i putnici-blogonamernici su dobrodošli ...
3. പൊക്കാളി പാടങ്ങളെ പുതിയ കരട് വിജ്ഞാപനത്തിൽ CRZ IB ൽ ഉൾപ്പെടുത്തിയതിയി കാണുന്നു. തദ്ദേശവാസികളുടെ പൊക്കാളി പാടങ്ങൾ കഴിഞ്ഞ വിജ്ഞാപനത്തിലെ പ്ലാനിൽ CRZ I(i) വിഭാഗത്തിൽ ഉൾപ്പെടുത്തിയത് സംബന്ധിച്ച് മാറ്റങ്ങൾ ആവശ്യമാണെന്ന് അംഗീകരിക്കുന്ന വിദഗ്ധ സമിതി റിപ്പോർട്ട് (മുളവുകാട് ഗ്രാമപഞ്ചായത്തിലെ പൊക്കാളി പാടങ്ങൾ സംബന്ധിക്കുന്നത്) KCZMA കൈവശം തന്നെ ഉണ്ട് എന്നാണ് അറിവ്. കേരള ...
... (Vietnamese: [tɨəŋ]) is the name applied to a variety of condiments a kind of fermented bean paste made from soybean and commonly used in Vietnamese cuisine. Originally, the term tương refers to a salty paste made from fermented soybeans, which is popular in vegetarian meals, particularly those prepared and eaten by Vietnamese Buddhist monks. It is also the most typical dipping sauce for summer rolls (gỏi cuốn). The paste, which is generally dark brown in color, is produced by adding the fungus Aspergillus oryzae to roasted soybeans, which are then allowed to naturally ferment in a jar with water until it develops an umami flavor. Other ingredients, such as glutinous rice or maize powder, salt, or water, may also be used. Tương is similar to the Chinese yellow soybean paste, though the latter is generally saltier and thicker in texture. Tương may range in consistency from a thick paste to a thin liquid. Some varieties, such as that prepared in Central Vietnam, are watery, ...
... (醬油) is considered almost as old as soy paste-a type of fermented paste (Jiang, 醬) obtained from soybeans-which had appeared during the Western Han dynasty (206 BC - 220 AD) and was listed in the bamboo slips found in the archaeological site Mawangdui (馬王堆).[6][5] There are several precursors of soy sauce that are associated products with soy paste. Among them the earliest one is Qingjiang (清醬) that had appeared in AD 40 and was listed in Simin Yueling (四民月令).[7] Others are Jiangqing (醬清), Chizhi (豉汁) and Chiqing (豉清) which are recorded in Qimin Yaoshu (齊民要術) in AD 540.[7] By the time of the Song dynasty (960-1279 AD), the term soy sauce (醬油) had become the accepted name for the liquid condiment,[7] which are documented in two books: Shanjia Qinggong (山家清供)[9] and Pujiang Wushi Zhongkuilu (浦江吳氏中饋錄)[10] during the Song dynasty (960-1279 AD). Like many salty condiments, soy sauce was originally
By layering and bunching the sheets in a certain manner, an imitation of chicken breast can be created with yuba. The effect is completed by frying the "skin" side of the tofu chicken until it is crispy. If stuffed with vegetables, it becomes tofu duck. Likewise various other meat alternatives have been made in this way, especially by Buddhist vegetarian restaurants in areas of Chinese culture.[3] The world's first meat analogs were developed in China, probably by Buddhist cooks in temples and monasteries.[4] The earliest process for making these meatless meats consisted of rolling thin sheets of doufupi, literally tofu skin, around a filling of minced, smoked, or other seasoned pieces of tofu skin, tying closed the bundle with string, and steaming until a meaty texture and flavor developed.[4] ...
The Tofurky roast is found in health food grocery stores; however, availability is limited in some areas. Inside the box, it comes in the form of a small but dense roast, wrapped tightly in a disposable casing, and is something of a rounded loaf in shape. It comes stuffed with mushrooms, herbs, and wild rice. Though the roast can be purchased separately, it is also offered as part of a meal with cranberry-apple-potato dumplings, gravy, and "wishstix"[4] made from Tofurky Jurky, a meatless jerky product. The Whole Foods store chain is a major seller of Tofurky products. Tofurky is a popular meat alternative[5] amongst many vegetarians, who avoid turkey for ethical and/or personal reasons. The product is free from turkey and other meat products. ...
... was founded in 1980, as a subsidiary of the Vandemoortele Group [nl] which is based in Belgium. Alpro expanded across Europe and in 2000 built a soy milk plant in Burton Latimer, England. In 2008 Alpro launched the UK's first "reduced calorie soya alternative to yogurt" following the introduction of its Soy Light "reduced calorie soya milk" in 2006.[11] Alpro's revenues are reported to have tripled during the period from 2000 to 2008. Beverages make up two-thirds of Alpro's revenues.[12] In June 2009 Vandemoortele sold Alpro for an estimated US$455 million to Dean Foods,[13][14] which marketed the "Silk" soy milk brand in the USA.[15] In June 2013, WhiteWave, the Dean Foods subsidiary that managed Alpro, was spun-off as an independent company - listing on the New York Stock Exchange.[16] In July 2013 Dean Foods sold their remaining 19.9% stake in WhiteWave, thus ending their involvement with Alpro.[17] In July 2016 it was announced that the French company Danone would purchase WhiteWave ...
... [1] (순두부찌개) or soft tofu stew[1] is a jjigae (Korean stew) in Korean cuisine. The dish is made with freshly curdled soft tofu (which has not been strained and pressed), vegetables, sometimes mushrooms, onion, optional seafood (commonly oysters, mussels, clams and shrimp), optional meat (commonly beef or pork), and gochujang (chili paste) or gochu garu (chili powder). The dish is assembled and cooked directly in the serving vessel, which is traditionally made of thick, robust porcelain, but can also be ground out of solid stone. A raw egg can be put in the jjigae just before serving, and the dish is delivered while bubbling vigorously. It is typically eaten with a bowl of cooked white rice and several banchan (side dishes).[2] Extra soft tofu, called sundubu (순두부; "mild tofu") in Korean, is softer than other types of tofu and is usually sold in tubes. Although sun in sundubu doesn't have Sino-Korean origin,[3] sundubu is often translated into Chinese and Japanese ...
... [2] (콩국수) or noodles in cold soybean soup[2] is a seasonal Korean noodle dish served in a cold soy milk broth. It comprises noodles made with wheat flour and soup made from ground soybeans.[3] It is unknown when Korean people started eating kongguksu; however, in accordance with the mention of the dish along with kkaeguksu (깨국수, sesame noodle soup) in Siui jeonseo, a Joseon cookbook published around the late 19th century, it is presumed to have originated at least as early as the 19th century.[4] ...
A condiment produced from a fermented paste of boiled soybeans, roasted grain, brine, and Aspergillus oryzae or Aspergillus sojae molds.[11] After fermentation, the paste is pressed, producing a liquid, which is the soy sauce, and a solid byproduct, which is often used as animal feed.[12] Soy sauce is a traditional ingredient in East and Southeast Asian cuisines, where it is used in cooking and as a condiment. It originated in China in the 2nd century BCE and spread throughout Asia. In recent times, it is used in Western cuisine and prepared foods. See also: Sweet soy sauce ...
... (揚げ出し豆腐, "Lightly deep-fried tofu") is a Japanese way to serve hot tofu. Silken (kinugoshi) firm tofu, cut into cubes, is lightly dusted with potato starch or cornstarch and then deep fried until golden brown. It is then served in a hot tentsuyu broth made of dashi, mirin, and shō-yu (Japanese soy sauce), with finely chopped negi (a type of spring onion), grated daikon or katsuobushi (dried bonito flakes) sprinkled on top.[1] ...
This is a list of soy-based foods. The soybean is a species of legume native to East Asia, widely grown for its edible bean which has numerous uses. The plant is classed as an oilseed rather than a pulse by the UN Food and Agriculture Organization (FAO). Many foods and dishes are prepared using soybeans as a primary ingredient. ...
Soybeans were first cultivated in China some 7000 years ago, while the earliest documented reference to the term "edamame" dates from the year 1275, when the Japanese monk Nichiren wrote a note thanking a parishioner for the gift of "edamame" he had left at the temple. [1] In 1406 during the Ming dynasty in China, the leaves of the soybeans were eaten and during outbreaks of famine, it was recommended for citizens to eat the beans whole or use them ground up and added to flour. Years later in China in 1620 they are referred to again, but as maodou, which translates to the term "hairy bean". They are found in the records of the Runan vegetable gardens and stated as having a medicinal purpose, as well as being a snack food.[1] Edamame appeared in haikai verse in Japanese in the Edo period (1603-1868), with one example as early as 1638.[2] They were first recognized in the United States in 1855, when a farmer commented on the difficulties he had shelling them after harvest. In March 1923, the ...
Sources differ about the earliest origin of nattō. One theory is that nattō was codeveloped in multiple locations in the distant past, since it is simple to make with ingredients and tools commonly available in Japan since ancient times.[9] However, the many different sources seem to agree on one thing: nattō is believed to be made from the encounter of boiled beans and straw. Minamoto no Yoshiie There is the story about Minamoto no Yoshiie, who was on a campaign in northeastern Japan between 1086 AD and 1088 AD, when one day, they were attacked while boiling soybeans for their horses. They hurriedly packed up the beans, and did not open the straw bags until a few days later, by which time the beans had fermented. The soldiers ate it anyway, and liked the taste, so they offered some to Yoshiie, who also liked the taste.[10][11] Prince Shotoku Another saying about the origin of nattō was based on Prince Shotoku, who wrapped the oddments of boiling soybeans in straw bags for his horse. As ...
Secondary cold agglutinin syndrome refers to cold agglutinin disease that is identified to be caused by viral infection, ... Cold agglutinins can cause two pathological conditions, that are, primary cold agglutinin disease (CAD) and secondary cold ... agglutinin syndrome (CAS), both of which are sole two subtypes of cold agglutinin disease. Primary cold agglutinin disease is ... Cold agglutinins (CA) are autoantibodies that agglutinate RBCs with a temperature optimum of 3-4 °C but may also act in a ...
The antigen on red blood cells that is bound by these cold agglutinins is known as the I antigen. Feizi worked with Sen-itiroh ... Almost one third of patients who suffer from atypical pneumonia develop cold agglutinins in their blood, which are misdirected ... Feizi, Ten (1969). Cold agglutinins and mycoplasma pneumoniae (Thesis). OCLC 926243918. "Dr. Ten Feizi wins 2014 Rosalind ... Her early research considered cold agglutinins, sensitive, misdirected antibodies that build up following mycoplasma pneumoniae ...
Pemberton R.T. (1994). "Agglutinins (lectins) from some British higher fungi". Mycological Research. 98 (3): 277-90. doi: ...
Wilson L (1954). "Sperm agglutinins in human semen and blood". Proceedings of the Society for Experimental Biology and Medicine ...
... and Marasmius oreades agglutinin - MOA. These four toxic lectins bind to specific glycan structures found in H. controtus. Some ...
A receptor, Peanut agglutinin receptor(PNAR)). This fact gave rise to the idea that spontaneous autoimmunity may result when ...
... and soybean agglutinins, which cannot be easily digested. ...
... a plant seed lectin and agglutinin from Helianthus tuberosus (Jerusalem artichoke). Agglutinin from Calystegia sepium (Hedge ... Proteins containing this domain include: Jacalin, a tetrameric plant seed lectin and agglutinin from Artocarpus heterophyllus ( ... Lectin MPA, a tetrameric plant seed lectin and agglutinin from Maclura pomifera (Osage orange). Heltuba lectin, ... which binds to the T-antigen and acts as an agglutinin. This domain is found in 1 to 6 copies in lectins. The domain is also ...
He proposed the A and B designations for the agglutinins. In 1910-1911 Hirszfeld discovered the heritability of blood groups ...
Coombs RR, Mourant AE, Race RR (1945). "Detection of weak and "incomplete" Rh agglutinins: a new test". Lancet. 246 (6358): 15- ...
Handelsman J, Ugalde RA, Brill WJ (March 1984). "Rhizobium meliloti competitiveness and the alfalfa agglutinin". Journal of ...
Pathologic cold agglutinins occur at titers over 1:1000 and react at 28-31 °C and sometimes at 37 °C. Cold agglutinin disease ... In chronic cold agglutinin disease, the patient is more symptomatic during the colder months. Cold agglutinin mediated ... Translocation (8;22) has also been reported in association with cold agglutinin disease. Transplantation: Cold agglutinin- ... Primary cold agglutinin disease Secondary cold agglutinin syndrome Associated with malignant disease Acute, transient, ...
"Cold Agglutinin Disease: Overview - eMedicine Pediatrics: General Medicine". Retrieved 2009-02-07. "Paroxysmal cold ...
Immunocytochemical Localization of Wheat Germ Agglutinin in Wheat. The Journal of cell Biology, Vol 92, No.3 Retrieved November ...
"A new test for the detection of weak and incomplete Rh agglutinins". British Journal of Experimental Pathology. 26: 255-66. PMC ...
A new test for the detection of weak and incomplete Rh agglutinins. Br J Exp Pathol 1945;26:255 Chown B, Lewis M, Kaita K ( ...
Partial List: Willims Jr, R. C.; Kunkel, H. G.; Capra, J. D. (1968). "Antigenic specificities related to the cold agglutinin ... "Nucleotide sequence analysis of the V regions of two IgM cold agglutinins. Evidence that the VH4-21 gene segment is responsible ...
Coombs RR, Mourant AE, Race RR (1945). "A new test for the detection of weak and incomplete Rh agglutinins". Br J Exp Pathol. ...
Soybean agglutinins (SBA) also known as soy bean lectins (SBL) are lectins found in soybeans. It is a family of similar legume ... Consumption of soybean agglutinin resulted in a depletion of lipid and an overgrowth of small intestine and pancreas in rats. ... Meanwhile, poor growth of spleen and kidneys and pancreatic hypertrophy was observed in the soybean agglutinin-fed rats.[5][6] ... Li, Z; Li, D; Qiao, S; Zhu, X; Huang, C (Aug 2003). "Anti-nutritional effects of a moderate dose of soybean agglutinin in the ...
Agglutinins are antibodies that cause the red blood cells to clump together. ... Cold agglutinins: no agglutination in titers at or below 1:16. The examples above are common measurements for results of these ... Febrile (warm) agglutinins are active at normal body temperatures.. This article describes the blood test that is used to ... Warm agglutinins may occur with:. *Infections, including brucellosis, rickettsial disease, salmonella infection, and tularemia ...
... when a cold agglutinin test is ordered, and what the results of a cold agglutinin test might mean ... Describes how a cold agglutinin test is used to help determine the cause of hemolytic anemia, ... A cold agglutinin test may be used to help detect cold agglutinin disease and determine the cause of a persons hemolytic ... A cold agglutinin test may rarely be ordered to identify increased cold agglutinins if someone has a condition that has been ...
Cold Agglutinins Related tests:. Complete Blood Count, Reticulocyte Count, Mycoplasma, Mono Test, Warm Agglutinins Why Get ... A cold agglutinin test may be used to help detect cold agglutinin disease and determine the cause of a persons hemolytic ... A cold agglutinin test may rarely be ordered to identify increased cold agglutinins if someone has a condition that has been ... This rare form of autoimmune hemolytic anemia is known as cold agglutinin disease. Cold agglutinin disease may be primary or ...
Agglutinin might also be associated with diseases of which the most common is an autoimmune disease known as cold agglutinin ... Agglutinins can also be any substance other than antibodies, such as sugar-binding protein lectins. When an agglutinin is added ... In cold agglutinin disease, the body produces agglutinins or antibodies that coagulate erythrocytes and lyse them at room ... individuals with cold agglutinin disease develop a form of anemia. A body might produce agglutinins to attack the erythrocytes ...
If you have cold agglutinin disease, keeping yourself warm might be all you need to do to deal with it. But if thats not ... American Society of Hematology: "Cold agglutinin disease," "Bendamustine plus rituximab for chronic cold agglutinin disease: ... Cold agglutinin disease (CAD) is a rare kind of anemia, a condition that happens when your body doesnt have enough red blood ... If you have cold agglutinin disease, you may be able to take part in one. Talk with your doctor to see if any are going on in ...
... the first manifestations of cold agglutinin disease can develop when a patient is subjected ... more ... Equestrian perniosis is a rare cause of persistent elevated titers of cold agglutinins.{ref20} Also rarely, ... Drugs & Diseases , Hematology , Cold Agglutinin Disease Q&A What are rare causes of cold agglutinin disease?. Updated: Aug 28, ... encoded search term (What are rare causes of cold agglutinin disease?) and What are rare causes of cold agglutinin disease? ...
... are normally made by the immune system in response to infection. They cause red blood cells to clump together ... A cold agglutinins blood test is done to check for conditions that cause the body to make certain types of antibodies called ... A cold agglutinins blood test is done to check for conditions that cause the body to make certain types of antibodies called ... your doctor may order a cold agglutinins test to see whether high cold agglutinin levels are present. ...
A review of Mayo Clinic patients with cold agglutinin disease identified underlying hematologic diseases in 69 of 89 patients ( ... Drugs & Diseases , Hematology , Cold Agglutinin Disease Q&A Which hematologic diseases are associated with cold agglutinin ... Jacobs A. Cold agglutinin hemolysis responding to fludarabine therapy. Am J Hematol. 1996 Dec. 53(4):279-80. [Medline]. ... Cao L, Kaiser P, Gustin D, Hoffman R, Feldman L. Cold agglutinin disease in a patient with uterine sarcoma. Am J Med Sci. 2000 ...
Cold agglutinin disease is a form of autoimmune hemolytic anemia caused by cold-reacting autoantibodies. Autoantibodies that ... encoded search term (Cold Agglutinin Disease) and Cold Agglutinin Disease What to Read Next on Medscape. Related Conditions and ... Primary cold agglutinin disease is characterized by a clonal lymphoproliferative disorder. [1, 2] Secondary cold agglutinin ... Primary cold agglutinin disease is usually associated with monoclonal cold-reacting autoantibodies. Primary cold agglutinin ...
Medical treatment manages cold agglutinin disease. There is no cure the disease. ... cold agglutinin anemia) is a rare, autoimmune disease. There are two types of the condition, primary and secondary. Signs and ... Cold agglutinin disease is not a genetic illness. There is either an unknown cause (primary cold agglutinin disease) or it is ... Symptoms of cold agglutinin disease (CAD) can be triggered or worsened by cold temperatures or viral infections and most people ...
Cold agglutinin disease is a form of autoimmune hemolytic anemia caused by cold-reacting autoantibodies. Autoantibodies that ... encoded search term (Cold Agglutinin Disease) and Cold Agglutinin Disease What to Read Next on Medscape. Related Conditions and ... Cold Agglutinin Disease Clinical Presentation. Updated: Aug 28, 2018 * Author: Salman Abdullah Aljubran, MD; Chief Editor: ... Jacobs A. Cold agglutinin hemolysis responding to fludarabine therapy. Am J Hematol. 1996 Dec. 53(4):279-80. [Medline]. ...
one of my twins was recently-and finally-diagnosed with Agglutinin... ... agglutinin disease - i am a mother of 5 with my youngest being twins. ... All Communities , Stay at Home Moms , agglutinin disease agglutinin disease Conni - posted on 06/18/2010 ( 1 mom has responded ... one of my twins was recently-and finally-diagnosed with Agglutinin Disease- a form of cold urticaria. is there any other moms ...
Cold agglutinins found in (idiopathic) cold haemagglutinin disease, mycoplasma pneumonia (anti-I); some lymphomas (anti-I or ...
Cold Agglutinin Disease Foundation was created by and for people with cold agglutinin disease (CAD) whose goal is to reach out ... Cold Agglutinin Disease Foundation. Address. 1874 State Route 70 E, Suite 4. Cherry Hill, NJ 08003 USA ... Cold agglutinin disease (cold antibody hemolytic anemia) is a rare autoimmune disorder characterized by the premature ... Home / For Patients and Families / Find a Patient Organization / Cold Agglutinin Disease Foundation ...
... (WGA) may be just as dangerous as gluten.. Before we get started on the possible issues of WGA I would ... Given the name, I would suspect that most of the wheat germ agglutinin is concentrated in the germ, which is not part of white ... Im new to this field, and there seems to be a huge amount of activity on the Internet regarding wheat germ agglutinin. However ... A study published in 1973 states that "wheat germ agglutinin is as effective as insulin in enhancing the rate of glucose ...
The PDB archive contains information about experimentally-determined structures of proteins, nucleic acids, and complex assemblies. As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists.
AGGLUTININ ISOLECTIN VI. A. 89. Urtica dioica. Mutation(s): 0 Gene Names: chia5.5.2, chia5.5.1. ... Urtica dioica agglutinin is a small plant lectin that binds chitin. We purified the isolectin VI (UDA-VI) and crystal ... Urtica dioica agglutinin is a small plant lectin that binds chitin. We purified the isolectin VI (UDA-VI) and crystal ... Crystal structures of Urtica dioica agglutinin and its complex with tri-N-acetylchitotriose.. Harata, K., Muraki, M.. (2000) J ...
We studied clinical and immunological characteristics of 15 patients with chronic cold agglutinin disease (CAD). Mean age at ... All patients had V(H)4-34 encoded IgM kappa cold agglutinins (CA) in high titre. In five patients IgM increased significantly ... We studied clinical and immunological characteristics of 15 patients with chronic cold agglutinin disease (CAD). Mean age at ...
Therapy of Chronic Cold Agglutinin Disease With Eculizumab Official Title ICMJE Therapy for Chronic Cold Agglutinin Disease: A ... Cold Agglutinin Disease Intervention ICMJE Drug: Eculizumab Weekly treatment with eculizumab (600 mg) via IV infusion for 4 ... Therapy of Chronic Cold Agglutinin Disease With Eculizumab (DECADE). The safety and scientific validity of this study is the ... Röth A, Dührsen U. Cold agglutinin disease. Eur J Haematol. 2010 Jan 1;84(1):91. doi: 10.1111/j.1600-0609.2009.01320.x. Epub ...
The Cold Agglutinin Disease E-Support Site is a website created by and for people with cold agglutinin disease (CAD) whose goal ... Cold Agglutinin Disease E-Support Site. Address. c/o Betty Usdan. 146 Greens Rd.. Hollywood, FL 33021 ... Home / For Patients and Families / Find a Patient Organization / Cold Agglutinin Disease E-Support Site ... Cold agglutinin disease (cold antibody hemolytic anemia) is a rare autoimmune disorder characterized by the premature ...
div class=product-description-paragraph,Composed of four subunits of approximately equal size, soybean agglutinin is a family ... Biotinylated Soybean agglutinin has an appropriate number of biotins bound to provide the optimum staining characteristics for ... Composed of four subunits of approximately equal size, soybean agglutinin is a family of closely related isolectins. This ...
Wheat germ agglutinin (WGA) is one of the most widely used lectins in cell biology. The receptor sugar for WGA is N- ... Wheat germ agglutinin (WGA) is one of the most widely used lectins in cell biology. The receptor sugar for WGA is N- ...
... and antonyms of the term AGGLUTININ in the Online Dictionary. What is a 10 letter word that starts with A? ... AGGLUTININ: Review the definition, meaning, pronunciation, explanation, synonyms, ...
This topic contains 43 study abstracts on Wheat Germ Agglutinin (WGA) indicating it may contribute to Thyroid Cancer, Kidney ... Wheat germ agglutinin (WGA) is used as a neural network tracer due to its ease of transit through the nervous system.Jan 01, ... Wheat germ agglutinin (WGA) and concanavalin bind to peripheral nerve fibres such as myelin in an animal model.Jan 01, 1996. ... Wheat germ agglutinin (WGA) has been shown to inhibit nuclear DNA replication and prevents transport into the cell nucleus.Jan ...
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The best binders were specific for the Abrus agglutinin, showing minimal binding to purified abrin fractions or unrelated ... Abrus agglutinin (a protein related to abrin but with lower toxicity), ricin, and unrelated proteins. Isolated sdAb were also ... explaining the selection of Abrus agglutinin binders. Used in conjunction with anti-abrin monoclonal and polyclonal antibodies ... Abrus agglutinin and distinguish between different crude preparations. ...
Peanut agglutinin binds preferentially to the T-antigen, a galactosyl (β-1,3) ,em,N,/em,-acetylgalactosamine structure present ... Peanut agglutinin binds preferentially to the T-antigen, a galactosyl (β-1,3) N-acetylgalactosamine structure present in many ... Peanut agglutinin binds preferentially to the T-antigen, a galactosyl (β-1,3) N-acetylgalactosamine structure present in many ... Cy5 labeled Peanut agglutinin has an appropriate number of fluorochromes bound to provide the optimum staining characteristics ...
Video articles in JoVE about peanut agglutinin include Chemically-blocked Antibody Microarray for Multiplexed High-throughput ... Peanut Agglutinin: Lectin purified from peanuts (Arachis hypogaea). It binds to poorly differentiated cells and terminally ...
Therapy of Chronic Cold Agglutinin Disease With Eculizumab (DECADE). The safety and scientific validity of this study is the ... Röth A, Dührsen U. Cold agglutinin disease. Eur J Haematol. 2010 Jan 1;84(1):91. doi: 10.1111/j.1600-0609.2009.01320.x. Epub ... Eculizumab in cold agglutinin disease (DECADE): an open-label, prospective, bicentric, nonrandomized phase 2 trial. Blood Adv. ... Long-term efficacy of the complement inhibitor eculizumab in cold agglutinin disease. Blood. 2009 Apr 16;113(16):3885-6. doi: ...
  • Urtica dioica agglutinin is a small plant lectin that binds chitin. (rcsb.org)
  • Biotinylated Soybean agglutinin has an appropriate number of biotins bound to provide the optimum staining characteristics for this lectin. (vectorlabs.com)
  • In the digital image above, a rat esophagus tissue section is presented that was labeled with the fluorophore Oregon Green 488 conjugated to wheat germ agglutinin, a fluorescent lectin that selectively binds to sialic acid residues. (microscopyu.com)
  • In short, H. cervicornis agglutinin showed important antinociceptive and anti-inflamatory activity via interaction with the lectin carbohydrate-binding site. (springer.com)
  • Wheat germ agglutinin, a C-type lectin and known label for TNTs, unexpectedly caused striking induction of TNTs. (whiterose.ac.uk)
  • Pinellia ternata leaf agglutinin gene ( pta ), encodes an insecticidal lectin, was isolated and cloned under the 35S and rolC promoters in the pGA482 plant transformation vector for Agrobacterium -mediated tobacco transformation. (ejbiotechnology.info)
  • Their binding ability towards wheat germ agglutinin was measured by competitive enzyme-linked lectin assays. (beilstein-journals.org)
  • The full-length cDNA of Arisaema lobatum agglutinin ( ala ) was 1078 bp and contained a 774 bp open reading frame encoding a lectin precursor (proproprotein) of 258 amino acid residues with a 23 aa signal peptide. (bioscirep.org)
  • We have synthesized a series of multivalent N-acetylglucosamine (GlcNAc) derivatives and studied their interaction with the plant lectin wheat germ agglutinin (WGA) by an enzyme-linked lectin assay (ELLA) and X-ray crystallography. (uni-konstanz.de)
  • Glanthus Nivalis Agglutinin (GNA) is a mannose binding lectin which has tendency for specific recognition and reversible binding to the sugar moieties of a wide variety of glycoproteins of enveloped viruses. (elsevier.com)
  • Roelcke D. The Lud cold agglutinin: a further antibody recognizing N-acetylneuraminic acid-determined antigens not fully expressed at birth. (medscape.com)
  • Cold agglutinin disease usually results from the production of a specific IgM antibody directed against the I/i antigens (precursors of the ABH and Lewis blood group substances) on red blood cells (RBCs). (medscape.com)
  • Cold agglutinins commonly have variable heavy-chain regions encoded by VH, with a distinct idiotype identified by the 9G4 rat murine monoclonal antibody. (medscape.com)
  • Other tests to detect cold agglutinin disease include complete blood count ( CBC ) to detect abnormal clumping (agglutination) of red blood cells, a physical examination for spleen or liver enlargement, and antiglobulin test (Coombs test) to detect the presence of a specific type of antibody (immunoglobulin M, or IgM). (rxlist.com)
  • Medical treatments for cold agglutinin disease include rituximab (Rituxan), a drug that is an antibody that selectively reduces specific types of immune cells). (rxlist.com)
  • Cold agglutinin disease (cold antibody hemolytic anemia) is a rare autoimmune disorder characterized by the premature destruction of red blood cells by the body's natural defenses against invading organisms (antibodies). (rarediseases.org)
  • Erythrocytes also may be agglutinated by agglutinins that are naturally present in the blood, such as the presence of anti A antibody in humans with the blood group B erythrocytes, or such agglutinins may also be formed in response to the entrance of noncompatible blood cells into the bloodstream. (thefreedictionary.com)
  • PARIS - November 14, 2020 - The U.S. Food and Drug Administration issued a Complete Response Letter (CRL) regarding the Biologics License Application (BLA) for sutimlimab, an investigational monoclonal antibody for the treatment of hemolysis in adults with cold agglutinin disease. (yahoo.com)
  • Sutimlimab is a humanized anti-C1s IgG4 monoclonal antibody that blocks the classical complement pathway-specific protease C1s and prevents further hemolysis in patients with cold agglutinin disease. (mdedge.com)
  • Several factors play a role in determining the ability of a cold agglutinin to induce a haemolytic anaemia such as antibody concentration and temperature range, in particular the highest temperature at which antibodies interact with red blood cells. (biomedcentral.com)
  • The alpha-agglutinin biosynthetic precursors did not react with antibody to beta 1,6-glucan, and the sizes of these forms were unaffected in kre mutants. (rupress.org)
  • Wheat germ agglutinin (WGA) may be just as dangerous as gluten. (robbwolf.com)
  • A study published in 1973 states that "wheat germ agglutinin is as effective as insulin in enhancing the rate of glucose transport and inhibiting epinephrine-stimulated lipolysis in isolated adipocytes" (Cuatrecasas, 1973). (robbwolf.com)
  • Wheat germ agglutinin (WGA) is one of the most widely used lectins in cell biology. (mpbio.com)
  • Patients with dermatitis herpetiformis have serum antibodies to wheat germ agglutinin and gluten. (greenmedinfo.com)
  • Wheat germ agglutinin (WGA) and concanavalin A bind to benign and malignant thyroid nodules. (greenmedinfo.com)
  • Wheat germ agglutinin (WGA) and concanavalin bind to peripheral nerve fibres such as myelin in an animal model. (greenmedinfo.com)
  • Wheat germ agglutinin (WGA) exhibits anti-nutritive properties, e.g. hypertrophic growth of the pancreas and thymus atrophy. (greenmedinfo.com)
  • Wheat germ agglutinin conjugates are often used as probes for the Golgi network in mammalian tissues and cells. (microscopyu.com)
  • This product is wheat germ agglutinin (WGA) labeled with Biotium's CF® Dyes or HRP. (biotium.com)
  • She had been using fluorescent wheat germ agglutinin (WGA) to figure out where the receptors are because WGA binds to leptin receptors. (marksdailyapple.com)
  • To further explore this issue we have used Wheat Germ Agglutinin (WGA) or Concanavalin A (Con A) to challenge rat small intestine and study the ultrastructural changes of such a treatment. (nih.gov)
  • Indeed, TNT-inducing effects of wheat germ agglutinin and thrombin were both correlated with cortical actin rearrangement and similarly Ca2+-dependent, suggesting common underlying mechanisms. (whiterose.ac.uk)
  • This product is the Agarose bound Wheat germ Agglutinin and has sugar specificity against N-Acetylglucosamine. (creativebiomart.net)
  • Wheat germ agglutinin (WGA) contains a group of closely related isolectins, with an isoelectric point about pH 9. (creativebiomart.net)
  • Pudendal nerve topography in the rat spinal cord projections studied with the axonal tracer wheat germ agglutinin conjugated-horseradish peroxidase. (semanticscholar.org)
  • article{Pascual1992PudendalNT, title={Pudendal nerve topography in the rat spinal cord projections studied with the axonal tracer wheat germ agglutinin conjugated-horseradish peroxidase. (semanticscholar.org)
  • The spinal cord termination of the sensory fibers of the rat pudendal nerve has been determined by using the transganglionic transport of horseradish peroxidase conjugated to wheat germ agglutinin. (semanticscholar.org)
  • Freeze-fracture cytochemistry: localization of wheat-germ agglutinin and concanavalin A binding sites on freeze-fractured pancreatic cells. (rupress.org)
  • The combined application of thin-section and critical-point-drying "fracture-label" is used to determine the pattern of distribution and partition of wheat-germ agglutinin and concanavalin A binding sites on the membrane faces of freeze-fractured exocrine and endocrine rat pancreatic cells. (rupress.org)
  • Whereas the exoplasmic face of plasma membrane is preferentially labeled by both lectins, the endoplasmic reticulum and nuclear envelope are strongly and uniformly labeled by concanavalin A but not by wheat-germ agglutinin. (rupress.org)
  • Knowing whether there are warm or cold agglutinins can help explain why the hemolytic anemia is occurring and direct treatment. (medlineplus.gov)
  • When the presence of cold agglutinins in a person's blood leads to significant RBC destruction, it can cause hemolytic anemia and lead to a low RBC count and hemoglobin . (labtestsonline.org)
  • This rare form of autoimmune hemolytic anemia is known as cold agglutinin disease. (labtestsonline.org)
  • A cold agglutinin test may be used to help detect cold agglutinin disease and determine the cause of a person's hemolytic anemia . (labtestsonline.org)
  • Cold agglutinin disease is a rare autoimmune disorder in which autoantibodies produced by a person's immune system mistakenly target and destroy RBCs, causing hemolytic anemia. (labtestsonline.org)
  • This test may be ordered when a person has reactions to cold temperature exposures and has signs of hemolytic anemia that may be due to cold agglutinin disease. (labcorp.com)
  • Cold agglutinin-mediated autoimmune hemolytic anemia. (medscape.com)
  • Wortman J, Rosse W, Logue G. Cold agglutinin autoimmune hemolytic anemia in nonhematologic malignancies. (medscape.com)
  • See whether high cold agglutinin levels are causing autoimmune hemolytic anemia. (healthwise.net)
  • Cold agglutinin disease is a rare form of autoimmune hemolytic anemia caused by cold-reacting autoantibodies. (medscape.com)
  • Cold agglutinin hemolytic anemia symptoms and signs include fatigue, cold hands, and leg pain. (rxlist.com)
  • Cold agglutinin disease is a rare form of acquired autoimmune hemolytic anemia in which exposure to cold temperatures can trigger the body's immune system to mistakenly attack and destroy its own red blood cells . (rxlist.com)
  • Cold agglutinin disease is often diagnosed based on evidence of hemolytic anemia (from symptoms and/or blood tests). (rxlist.com)
  • The severity of the clinical manifestations of the cold agglutinins themselves varies from an inconsequential laboratory finding, in cases of the benign variety, to serious manifestations, such as acute hemolytic crises and Raynaud-type phenomena, in cases of the more malignant variety. (medscape.com)
  • In people with Cold Agglutinin Disease , an excess of Cold Agglutinins can lead to the destruction of too many RBC's resulting in Hemolytic Anemia . (requestatest.com)
  • Cold Agglutinin hemolytic anemia due to cold autoantibodies associated with Mycoplasma pneumoniae is rare. (annals.org)
  • Cold agglutinin disease (CAD) is a rare autoimmune hemolytic anemia mediated by autoantibodies that preferentially react at 4°C. Laboratory testing for cold-reactive autoantibodies is laborious and may not be ordered judiciously, particularly in patients with a negative direct antiglobulin test (DAT). (ovid.com)
  • 1. A study has been made by means of agglutination and absorption of agglutinin tests, of the antigenic relationships of 54 strains of hemolytic streptococci associated with an epidemic of puerperal fever in a large city obstetric hospital. (rupress.org)
  • Cold agglutinin disease is a rare, acquired chronic autoimmune hemolytic condition that destroys red blood cells. (mdedge.com)
  • The diagnosis of cold agglutinin disease requires the presence of hemolytic anemia, a cold agglutination titer greater than 1:64 at 4 degrees Celsius, and a polyspecific direct Coombs test or monospecific direct Coombs for C3d. (cancertherapyadvisor.com)
  • These laboratory tests determine the presence of hemolytic anemia, agglutination, and cold agglutinin titers. (cancertherapyadvisor.com)
  • I have a secondary CAD (Cold Agglutinin Disease) linked to IgM Kappa as well as a Coombs Positive Hemolytic Anemia. (coldagglutinindisease.org)
  • A Cold Agglutinin Titer Blood Test is used to support the diagnosis of primary atypical pneumonia, infection with Mycoplasma Pneumoniae, and hemolytic anemia, gangrene, cirrhosis, Raynaud disease, some viral diseases, and infectious diseases such as staphylococcemia, influenza, and tuberculosis. (walkinlab.com)
  • Soybean agglutinin, Glycine max. (wikipedia.org)
  • Studies on rats fed SBA had complex changes: With increasing doses of soybean agglutinin, the activities of aspartate aminotransferase linearly increased in plasma and decreased plasma insulin content without decrease in blood glucose levels. (wikipedia.org)
  • Consumption of soybean agglutinin resulted in a depletion of lipid and an overgrowth of small intestine and pancreas in rats. (wikipedia.org)
  • Meanwhile, poor growth of spleen and kidneys and pancreatic hypertrophy was observed in the soybean agglutinin-fed rats. (wikipedia.org)
  • Composed of four subunits of approximately equal size, soybean agglutinin is a family of closely related isolectins. (vectorlabs.com)
  • Abstract: Soybean agglutinin (SBA), is a non-fiber carbohydrate related protein and a major anti-nutritional factor. (mdpi.com)
  • Pan L, Zhao Y, Farouk MH, Bao N, Wang T, Qin G. Integrins Were Involved in Soybean Agglutinin Induced Cell Apoptosis in IPEC-J2. (mdpi.com)
  • Cold agglutinins are autoantibodies produced by a person's immune system that mistakenly target red blood cells (RBCs). (labtestsonline.org)
  • Primary cold agglutinin disease is usually associated with monoclonal cold-reacting autoantibodies. (medscape.com)
  • Secondary cold agglutinin disease may be associated with either monoclonal or polyclonal cold-reacting autoantibodies. (medscape.com)
  • Cold agglutinins, or cold autoantibodies, occur naturally in nearly all individuals. (medscape.com)
  • This test measures the level of Cold Agglutinin Autoantibodies in the blood. (requestatest.com)
  • Rarer cases of the disease are caused by IgM autoantibodies, which bind to red cell surfaces only at temperatures lower than normal body temperature (cold agglutinins). (renalandurologynews.com)
  • In this type, IgM autoantibodies, or cold agglutinins, bind red blood cells when the blood is exposed to cold temperatures, specifically 32° to 39.2°F (0° to 4°C). This accounts for 10-20 percent of cases. (medicalnewstoday.com)
  • Soybean agglutinins (SBA) also known as soy bean lectins (SBL) are lectins found in soybeans . (wikipedia.org)
  • Agglutinins can also be any substance other than antibodies, such as sugar-binding protein lectins. (wikipedia.org)
  • A novel agglutinin with specificity for sialic acid sequence of sugars in thyroglobulin is identified in the hemolymph of Scylla serrata . (springer.com)
  • This product is the Agarose bound Pisum Sativum Agglutinin (PSA) and has sugar specificity against Mannose and Glucose. (creativebiomart.net)
  • Pisum sativum agglutinin is nearly identical in structure and carbohydrate specificity to Lens culinaris agglutinin. (creativebiomart.net)
  • The result of a cold agglutinin test is typically reported as a titer, such as 1:64 or 1:512. (labcorp.com)
  • Salivary agglutinin is a 300-400kDa salivary glycoprotein that binds to antigen B polypeptides of oral streptococci, thereby playing a role in their colonization and the development of caries. (biochemj.org)
  • It was shown by Western blotting that monoclonal antibodies against gp-340 reacted with salivary agglutinin, and monoclonals against agglutinin reacted with gp-340. (biochemj.org)
  • Leicester Research Archive: Evolution of the rapidly mutating human salivary agglutinin gene (DMBT1) and population subsistence strategy. (le.ac.uk)
  • Salivary agglutinin [SAG, encoded by the deleted in malignant brain tumors 1 (DMBT1) gene] is an innate immune receptor glycoprotein that binds a variety of bacteria and viruses, and mediates attachment of S. mutans to hydroxyapatite on the surface of the tooth. (le.ac.uk)
  • Bikker, F.J.. / Salivary Agglutinin : Structure and function . (vu.nl)
  • The variability of hemolysis in the cold agglutinin syndrome. (medscape.com)
  • Jacobs A. Cold agglutinin hemolysis responding to fludarabine therapy. (medscape.com)
  • Unlike cold agglutinin disease, in which affected RBCs are removed via extravascular phagocytosis, paroxysmal cold hemoglobinuria involves intravascular hemolysis. (medscape.com)
  • In a first-in-human trial, sutimlimab rapidly halted hemolysis, corrected anemia, precluded the need for transfusion, and caused no serious adverse effects in patients with cold agglutinin disease. (mdedge.com)
  • Idiopathic cold agglutinin disease is usually benign, and most patients need only take protective measures against cold temperatures. (medscape.com)
  • An 80-year-old man with idiopathic cold agglutinin disease presented with acute cholecystitis. (bmj.com)
  • Equestrian perniosis is a rare cause of persistent elevated titers of cold agglutinins. (medscape.com)
  • High titers of cold agglutinins may be caused by infections, such as pneumonia caused by mycoplasma, mononucleosis , hepatitis C , or other viral infections. (healthwise.net)
  • High titers of cold agglutinins can cause symptoms when a person is exposed to cold temperatures. (healthwise.net)
  • Newer tests for mycoplasma pneumonia have replaced the cold agglutinins blood test. (healthwise.net)
  • Conversely, agglutination can also be used to identify new bacteria or cells with a specific antigen by exposing them to serum containing known agglutinins. (wikipedia.org)
  • On the whole, at least in the author's experience, the preparation of species-specific antiserum fractions and the differentiation of closely related species with precipitin sera for serum proteins does not succeed so regularly as with agglutinins and lysins for blood cells. (todayinsci.com)
  • This is actually the case, since every serum contains those agglutinins which react with the agglutinogens not present in the cells a remarkable phenomenon, the cause of which is not yet known for certain. (todayinsci.com)
  • The cold agglutinin test is not routinely ordered. (labtestsonline.org)
  • Sometimes a cold agglutinin test may be run at one or more additional temperatures that are lower than body temperature but warmer than 4°C, such as performed at 30°C (86°F) to determine the point at which the RBCs start to clump. (labcorp.com)
  • A cold agglutinin test may rarely be ordered to identify increased cold agglutinins if someone has a condition that has been linked to secondary cold agglutinin disease, such as infectious mononucleosis or a Mycoplasma pneumoniae infection. (labcorp.com)
  • A Cold Agglutinin test is typically ordered as a follow up to a CBC which shows low numbers of RBC's and Hemoglobin, especially when these results seem linked to cold weather. (requestatest.com)
  • When an agglutinin is added to a uniform suspension of particles, such as bacteria or blood, in a test tube (in vitro), agglutinin binds to the agglutinin-specific structure on the particle causing the particles to aggregate and fall to the bottom, leaving a clear suspension. (wikipedia.org)
  • Peanut agglutinin binds preferentially to the T-antigen, a galactosyl (β-1,3) N -acetylgalactosamine structure present in many glycoconjugates such as M and N blood groups, gangliosides, and many other soluble and membrane-associated glycoproteins and glycolipids. (vectorlabs.com)
  • A sequential, quantitative loss of Peanut agglutinin (PNA) binding with progression of mouse mammary cells from normal to preneoplastic to neoplastic phenotypes was observed. (nih.gov)
  • Objective: The research team intended to measure IgG and IgE antibodies against peanut proteins, agglutinins, and oleosins to identify variations in IgG and IgE immune reactivities to these antigens among the general population. (immunoscienceslab.com)
  • Outcome measures: The sera were screened for peanut-specific IgG and IgE antibodies against water-soluble proteins of peanut, peanut agglutinins, and peanut oleosins, using the ELISA. (immunoscienceslab.com)
  • Results: Using mean values as the cutoff, 19%, 17%, and 22% of the specimens tested for IgG antibodies and 14%, 11%, and 14% of the specimens tested for IgE antibodies produced high levels of antibodies against peanut proteins, agglutinins, and oleosins, respectively. (immunoscienceslab.com)
  • A method for specifically labeling of mammalian cone photoreceptors in vivo comprising injecting a mammal with peanut agglutinin conjugated with a fluorescent probe. (patentsencyclopedia.com)
  • The peanut agglutinin labels the cone photoreceptor. (patentsencyclopedia.com)
  • [0001] This invention relates to a novel, method of in vivo labeling of outer and inner segments, and pedicles of mammalian cone photoreceptors by intravitreal injection of fluorescently tagged peanut agglutinin. (patentsencyclopedia.com)
  • What are the signs and symptoms of cold agglutinin disease? (rxlist.com)
  • Other symptoms of cold agglutinin disease include pain and bluish coloring of the hands and feet and mottled discoloration of the skin. (rxlist.com)
  • Treatment for cold agglutinin disease depends on the underlying cause, the symptoms present in an individual, and the severity of the illness. (rxlist.com)
  • In primary cold agglutinin disease, or in patients with minimal symptoms or mild anemia, treatment often consists of measures to avoid getting cold. (rxlist.com)
  • In cases of secondary cold agglutinin disease caused by bacterial or viral infections, the symptoms typically go away on their own within 6 months after the bacterial or viral infection has resolved. (rxlist.com)
  • The prognosis for people with cold agglutinin disease varies based on the severity of the illness, the signs and symptoms, and any underlying cause. (rxlist.com)
  • The outlook for people with secondary cold agglutinin disease caused by bacterial or viral infections is excellent prognosis and cold agglutinin disease symptoms usually go away within 6 months after the infection has resolved. (rxlist.com)
  • Other symptoms of cold agglutinin disease, such as a history of weight loss and adenopathy, can be related to the underlying disease state associated with the production of cold agglutinins. (medscape.com)
  • The DelveInsight Cold Agglutinin Disease (CAD) epidemiology report gives a thorough understanding of the Cold Agglutinin Disease (CAD) by including details such as disease definition, symptoms, causes, pathophysiology, and diagnosis. (delveinsight.com)
  • Human monoclonal antibodies encoded by the V4-34 gene segment show cold agglutinin activity and variable multireactivity which correlates with the predicted charge of the heavy-chain variable region. (medscape.com)
  • Severe cold agglutinin disease and cryoglobulinemia secondary to a monoclonal anti-Pr2 IgM lambda cryoagglutinin. (medscape.com)
  • Monoclonal cold agglutinin IgM antibodies found in patients with lymphoma are the product of the abnormal clone. (medscape.com)
  • Through gel analysis and the behavior of anti-abrin monoclonal antibodies, we determined that the commercial toxoid preparation used for the original immunizations contained a high percentage of Abrus agglutinin, explaining the selection of Abrus agglutinin binders. (mdpi.com)
  • Used in conjunction with anti-abrin monoclonal and polyclonal antibodies, these reagents can fill a role to discriminate between the highly toxic abrin and the related, but much less toxic, Abrus agglutinin and distinguish between different crude preparations. (mdpi.com)
  • Results of colorimetric assays of active column fractions indicated that the agglutinin is a glycoprotein composed of protein, hexose and uronic acid. (oregonstate.edu)
  • The selected sdAb were evaluated for their ability to bind to commercial abrin as well as abrax (a recombinant abrin A-chain), purified abrin fractions, Abrus agglutinin (a protein related to abrin but with lower toxicity), ricin, and unrelated proteins. (mdpi.com)
  • 3D Structure of human the para influenza virus (HPIV) type-3 haem agglutinin neuraminidase protein (A) 1V2I, (B) 1V3E, (C) 1V3B, (D) 1V3D, (E) 4MZA). (nih.gov)
  • Agglutinin is active against only live bacteria and requires the divalent cation Mg⁺⁺. In the purest agglutinin preparations obtained less than one ug each of protein, hexose, and uronic acid was required to agglutinate 10⁸ cells of P. putida. (oregonstate.edu)
  • It was demonstrated that gp-340 and agglutinin bound in a similar way to Streptococcus mutans and surfactant protein-D. Histochemically, the distribution of gp-340 in the submandibular salivary glands was identical with the agglutinin distribution, as shown in a previous paper [Takano, Bogert, Malamud, Lally and Hand (1991) Anat. (biochemj.org)
  • We conclude that agglutinin is identical with gp-340, and that this molecule interacts with S. mutans and surfactant protein-D. (biochemj.org)
  • The cell adhesion protein alpha-agglutinin is bound to the outer surface of the Saccharomyces cerevisiae cell wall and mediates cell-cell contact in mating. (rupress.org)
  • Agglutination, using blood agglutinins known as hemagglutinins, is used diagnostically to identify blood types of human beings based on the reaction between the erythrocyte (Red blood cell) antigens and agglutinins. (wikipedia.org)
  • The inability of other NeuGc-glycoproteins (bovine submaxillary mucin) to inhibit the agglutination suggests that the agglutinin may also recognize glycosidic linkage associated with NeuGc. (springer.com)
  • When the invading agents that bring about the production of agglutinins are bacteria, the agglutinins produced bring about agglutination of the bacterial cells both in vivo and in vitro. (thefreedictionary.com)
  • A transfusion reaction is an example of the result of agglutination of blood cells brought about by agglutinins present in the recipient's blood. (thefreedictionary.com)
  • 4. By reciprocal agglutination and absorption of agglutinin tests, six of these strains were demonstrated to be antigenically identical. (rupress.org)
  • 5. By agglutination and complete absorption of agglutinin, sixteen more strains showed their antigenic similarity to, if not identity with, these other six strains. (rupress.org)
  • Cold Agglutinins are a type of autoantibody which mistakenly target and destroy a person's red blood cells, causing them to clump together. (requestatest.com)
  • Cold agglutinin disease (CAD) is a rare (approximately 1:100,000) disorder in which a red cell autoantibody, primarily IgM (immunoglobulin M), fixes complement in vivo. (cancertherapyadvisor.com)
  • A novel agglutinin gene was cloned from Arisaema lobatum using SMART RACE-PCR technology. (bioscirep.org)
  • Below are the list of possible Alpha-agglutinin products. (mybiosource.com)
  • Also known as Alpha-agglutinin (AG-alpha-1). (mybiosource.com)
  • Glycosyl phosphatidylinositol-dependent cross-linking of alpha-agglutinin and beta 1,6-glucan in the Saccharomyces cerevisiae cell wall. (rupress.org)
  • alpha-Agglutinin is modified by addition of a glycosyl phosphatidylinositol (GPI) anchor as it traverses the secretory pathway. (rupress.org)
  • A pathway for cell wall anchorage of Saccharomyces cerevisiae alpha-agglutinin. (rupress.org)
  • Cell wall association of alpha-agglutinin was accompanied by an increase in size and a gain in reactivity to antibodies directed against beta 1,6-glucan. (rupress.org)
  • Several kre mutants, which have defects in synthesis of cell wall beta 1,6-glucan, had reduced molecular size of cell wall alpha-agglutinin. (rupress.org)
  • These findings demonstrate that the cell wall form of alpha-agglutinin is covalently associated with beta 1,6-glucan. (rupress.org)
  • A COOH-terminal truncated form of alpha-agglutinin, which is not GPI anchored and is secreted into the medium, did not react with the anti-beta 1,6-glucan. (rupress.org)
  • We propose that extracellular cross-linkage to beta 1,6-glucan mediates covalent association of alpha-agglutinin with the cell wall in a manner that is dependent on prior addition of a GPI anchor to alpha-agglutinin. (rupress.org)
  • Primary cold agglutinin disease typically affects those who are middle age to elderly, and it tends to continue over time ( chronic ). (labtestsonline.org)
  • Secondary cold agglutinin disease may affect anyone and may be acute or chronic, temporary or persistent. (labtestsonline.org)
  • Primary chronic cold agglutinin disease: an update on pathogenesis, clinical features and therapy. (medscape.com)
  • In chronic cold agglutinin disease, the patient is more symptomatic during the colder months. (medscape.com)
  • Primary cold agglutinin disease is chronic and occurs after the fifth decade of life, with a peak incidence in the seventh and eighth decades. (medscape.com)
  • Splenomegaly and jaundice, characteristic of lymphoproliferative disorders or infectious mononucleosis, are usually absent, but they may sometimes be observed in patients with chronic cold agglutinin disease. (medscape.com)
  • Clinical immunology of chronic cold agglutinin disease. (biomedsearch.com)
  • We studied clinical and immunological characteristics of 15 patients with chronic cold agglutinin disease (CAD). (biomedsearch.com)
  • Agglutinins are antibodies that cause the red blood cells to clump together. (medlineplus.gov)
  • Agglutinins can be antibodies that cause antigens to aggregate by binding to the antigen-binding sites of antibodies. (wikipedia.org)
  • Cold agglutinins are active at cold temperatures. (medlineplus.gov)
  • Febrile (warm) agglutinins are active at normal body temperatures. (medlineplus.gov)
  • Cold Agglutinins are activated when the body is exposed to cold temperatures. (requestatest.com)
  • Cold agglutinin disease may be primary or secondary, induced by some other disease or condition. (labtestsonline.org)
  • Polyclonal secondary cold agglutinin disease, which occurs in children and young adults, is usually transient. (medscape.com)
  • Cold agglutinin disease is classified as primary (unknown cause) or secondary (caused by an underlying condition). (rxlist.com)
  • There is either an unknown cause (primary cold agglutinin disease) or it is caused by another condition called secondary cold agglutinin disease. (rxlist.com)
  • In secondary cold agglutinin disease that results from another medical condition, it is important to treat the underlying condition. (rxlist.com)
  • Secondary Antibodies-Ricinus communis (castor bean) Agglutinin (RCA120)-biotin conjugate-Alpha Diagnostic International Inc. (4adi.com)
  • The potential of the agglutinin in identifying NeuGc containing human tumor associated antigens is discussed. (springer.com)
  • Sometimes, high levels of cold agglutinins can cause blood to clump in blood vessels under the skin when the skin is exposed to the cold. (healthwise.net)
  • [ 21 ] It is found on cold agglutinin-producing malignant lymphoid cells in the bone marrow in persons with lymphoproliferative disorders, on a small proportion of normal lymphoid cells, and in the spleen of a 15-week-old fetus. (medscape.com)
  • Molecular characterization of cold agglutinins. (medscape.com)
  • In its classic presentation with haemolytic anaemia and Raynaud's syndrome, cold agglutinin disease is usually idiopathic. (biomedcentral.com)
  • I hope a hematopathologist will give our technical colleagues a brief review on the lab findings of cold agglutinin syndrome. (transfusion.ca)
  • The best binders were specific for the Abrus agglutinin, showing minimal binding to purified abrin fractions or unrelated proteins. (mdpi.com)
  • We focused on the sugar chain in the Tg molecule and investigated the usefulness of Lens culinaris agglutinin (LCA)-reactive Tg ratios in sera and wash fluids obtained during fine-needle aspiration (FNA) for the detection of thyroid carcinoma. (hu-berlin.de)
  • Several serological tests including alpha-fetoprotein (AFP), the ratio of lens culinaris agglutinin-reactive alpha-fetoprotein to total AFP (AFP-L3/AFP), des-gamma carboxyprothrombin (DCP), and glypican-3 (GPC-3) have been widely investigated as diagnostic biomarkers for early-stage HCC in at-risk populations. (biomedcentral.com)
  • The production of excess cold agglutinins is often linked to other conditions such as Mycoplasma Pneumoniae, infectious mononucleosis, some cancers, bacterial infections, parasitic infections, viral infections such as HIV and influenza. (requestatest.com)
  • Cold agglutinin disease often occurs transiently after infection with Mycoplasma pneumoniae or Epstein-Barr virus. (thefreedictionary.com)
  • Autoimmune and lymphoproliferative disorders, Mycoplasma pneumoniae and other infections can be associated with the production of cold agglutinins. (biomedcentral.com)
  • Cold agglutinin antibodies are mainly specific for the I/i and H RBCs membrane systems [ 6 ], and their production can be stimulated by Mycoplasma pneumoniae or infection by the Epstein-Barr virus, as well as by lymphoproliferative disorders such as Waldenström's macroglobulinemia. (biomedcentral.com)
  • Immunoglobulin heavy and light chain gene features are correlated with primary cold agglutinin disease onset and activity. (medscape.com)
  • Naturally occurring anti-i/I cold agglutinins may be encoded by different VH3 genes as well as the VH4.21 gene segment. (medscape.com)
  • Approximately two decades have passed since the description of the first gene in the Candida albicans ALS (agglutinin-like sequence) family. (frontiersin.org)
  • The exact temperature at which this will occur will vary as some cold agglutinins will react over a wider temperature range than others. (labcorp.com)
  • Pathologic cold agglutinins occur at titers over 1:1000 and react at 28-31°C and sometimes at 37°C. (medscape.com)
  • These antibodies are most commonly IgG, and react with proteins on the surface of red blood cells at normal body temperature (warm agglutinins). (renalandurologynews.com)
  • A common complaint among patients with cold agglutinin disease is painful fingers and toes with purplish discoloration associated with cold exposure. (medscape.com)
  • Anemia in patients with cold agglutinin disease may be mild, moderate, or severe. (medscape.com)
  • We retrospectively studied 232 patients with cold agglutinin disease (CAD) at 24 centers in five countries. (onmedica.com)
  • We describe operating room and anaesthetic considerations for patients with cold agglutinin disease and measures that can be taken to prevent disease exacerbation in this case report. (bmj.com)
  • Saccharomyces cerevisiae A and alpha cells express the complementary cell surface glycoproteins A-agglutinin and alpha-, respectively, which interact with one another to promote cellular aggregation during mating. (mybiosource.com)
  • Primary cold agglutinin disease is characterized by a clonal lymphoproliferative disorder. (medscape.com)
  • Mild to moderate primary (unknown cause) cold agglutinin disease may also have a good prognosis if cold exposure is avoided. (rxlist.com)
  • 1.5 gram per deciliter (g/dL) increase in hemoglobin (Hgb) level and avoidance of transfusion in participants with primary cold agglutinin disease (CAD) without a recent history of blood transfusion. (clinicaltrials.gov)
  • A participant will be considered a responder if he or she did not receive a blood transfusion from Week 5 through Week 26 (EOT) and did not receive treatment for primary cold agglutinin disease (CAD) beyond what is permitted per protocol. (clinicaltrials.gov)
  • We experienced a case of ARDS due to mycoplasma pneumonia associated with cold agglutinin disease in primary CNS lymphoma. (koreamed.org)
  • He was a 60-year old primary CNS lymphoma patient with mycoplasma pneumonia and cold agglutinin disease who rapidly progressed to ARDS after 1 cycle of chemotherapy. (koreamed.org)
  • If a disease linked to cold agglutinin is suspected, the person needs to be kept warm. (medlineplus.gov)
  • Agglutinin might also be associated with diseases of which the most common is an autoimmune disease known as cold agglutinin disease. (wikipedia.org)
  • In cold agglutinin disease, the body produces agglutinins or antibodies that coagulate erythrocytes and lyse them at room temperature or lower. (wikipedia.org)
  • In individuals that have cold agglutinin disease, the lifespan of erythrocytes is shortened. (wikipedia.org)
  • The rate of erythrocyte production by the bone marrow is lower than the rate of destruction, thus, individuals with cold agglutinin disease develop a form of anemia. (wikipedia.org)
  • What Is Cold Agglutinin Disease? (wikipedia.org)
  • Cold agglutinin disease (CAD) is a rare kind of anemia, a condition that happens when your body doesn't have enough red blood cells. (webmd.com)
  • Doctors used to think taking out your spleen helped fight cold agglutinin disease. (webmd.com)
  • If you have cold agglutinin disease, you may be able to take part in one. (webmd.com)
  • What are rare causes of cold agglutinin disease? (medscape.com)
  • [ 20 ] Also rarely, the first manifestations of cold agglutinin disease can develop when a patient is subjected to hypothermia for cardiopulmonary bypass surgery. (medscape.com)
  • Which hematologic diseases are associated with cold agglutinin disease? (medscape.com)
  • These are typical of aggregates seen in persons with cold agglutinin disease. (medscape.com)
  • Glucocorticoids are generally not useful in IgM-induced cold agglutinin disease but may occasionally work in selected patients. (medscape.com)
  • What should you know about cold agglutinin disease? (rxlist.com)
  • Is cold agglutinin disease inherited (genetic)? (rxlist.com)
  • Cold agglutinin disease is not a genetic illness. (rxlist.com)
  • Who has cold agglutinin disease? (rxlist.com)
  • Middle-aged and older adults are most commonly affected with cold agglutinin disease. (rxlist.com)
  • Certain illnesses such as infectious mononucleosis , lymphoproliferative diseases, or mycoplasma pneumonia can make people more susceptible to developing cold agglutinin disease. (rxlist.com)
  • What procedures and tests diagnose cold agglutinin disease? (rxlist.com)
  • How do you treat cold agglutinin disease? (rxlist.com)
  • Use of corticosteroids and removal of the spleen have not been shown to be effective treatments for cold agglutinin disease. (rxlist.com)
  • Cold agglutinin disease is not a form of cancer . (rxlist.com)
  • Can cold agglutinin disease be cured? (rxlist.com)
  • What is the prognosis and life expectancy for cold agglutinin disease? (rxlist.com)
  • People who have cold agglutinin disease caused by certain types of cancer or HIV infection generally have a poorer prognosis and possibly a shorter life expectancy due to their underlying condition. (rxlist.com)
  • No evidence of such a response exists in cold agglutinin disease. (medscape.com)
  • one of my twins was recently-and finally-diagnosed with Agglutinin Disease- a form of cold urticaria. (circleofmoms.com)
  • Cold Agglutinin Disease Foundation was created by and for people with cold agglutinin disease (CAD) whose goal is to reach out to others with CAD to offer them an opportunity for support and encouragement. (rarediseases.org)
  • Cold agglutinin disease revisited: A multinational, observational study of 232 patients. (onmedica.com)
  • In this and in similar cases that have been reported, the coexistence of anti-Pr cold agglutinins and peripheral neuropathy suggest that they might be the causative agents of the disease. (gla.ac.uk)
  • No drug has yet been approved to treat cold agglutinin disease. (mdedge.com)
  • The phase 1 trial of sutimlimab (formerly BIVV009 and TNT009) in cold agglutinin disease was conducted at the Medical University of Vienna in Austria and reported in Blood . (mdedge.com)
  • Patients had cold agglutinin disease for a median of 5 years (range, 1 - 20). (mdedge.com)
  • Provided that safety results remain positive, sutimlimab could become the first approved treatment for cold agglutinin disease," said corresponding author Bernd Jilma, MD, of the Medical University of Vienna in Austria. (mdedge.com)
  • Are you sure your patient has cold agglutinin disease? (cancertherapyadvisor.com)
  • DelveInsight's ' Cold Agglutinin Disease (CAD) - Epidemiology Forecast to 2030 ' report delivers an in-depth understanding of the disease, historical and forecasted Cold Agglutinin Disease (CAD) epidemiology in the 7MM, i.e., the United States, EU5 (Germany, Spain, Italy, France, and the United Kingdom), and Japan. (delveinsight.com)
  • It also provides treatment algorithms and treatment guidelines for Cold Agglutinin Disease (CAD) in the US, Europe, and Japan. (delveinsight.com)
  • The report covers the detailed information of the Cold Agglutinin Disease (CAD) epidemiology scenario in seven major countries (US, EU5, and Japan). (delveinsight.com)
  • The Cold Agglutinin Disease (CAD) epidemiology division provides insights about historical and current patient pool and forecasted trend for every seven major countries. (delveinsight.com)
  • The Cold Agglutinin Disease (CAD) epidemiology data are studied through all possible division to give a better understanding of the Disease scenario in 7MM. (delveinsight.com)
  • The Cold Agglutinin Disease (CAD) epidemiology segment covers the epidemiology data in the US, EU5 countries (Germany, Spain, Italy, France, and the UK), and Japan from 2017 to 2030. (delveinsight.com)
  • The Cold Agglutinin Disease (CAD) epidemiology covered in the report provides historical as well as forecasted Cold Agglutinin Disease (CAD) epidemiology scenario in the 7MM covering the United States, EU5 countries (Germany, Spain, Italy, France, and the United Kingdom) and Japan from 2017 to 2030. (delveinsight.com)
  • The DelveInsight Cold Agglutinin Disease (CAD) report also provides the epidemiology trends observed in the 7MM during the study period, along with the assumptions undertaken. (delveinsight.com)
  • What will be the growth opportunities in the 7MM with respect to the patient population pertaining to Cold Agglutinin Disease (CAD)? (delveinsight.com)
  • What are the key findings pertaining to the Cold Agglutinin Disease (CAD) epidemiology across 7MM and which country will have the highest number of patients during the forecast period (2017-2030)? (delveinsight.com)
  • What would be the total number of patients of Cold Agglutinin Disease (CAD) across the 7MM during the forecast period (2017-2030)? (delveinsight.com)
  • It was set up and had been used since the late 60's to establish if a cold agglutinin was present to cause non-specific reactions or panagglutination or for the diagnosis of patients for cold agglutinin disease. (transfusion.ca)
  • A body might produce agglutinins to attack the erythrocytes due to allergies to foods, inhalants, chemicals and infections. (wikipedia.org)
  • Roelcke D. Reaction of anti-Gd, anti-Fl and anti-Sa cold agglutinins with p erythrocytes. (medscape.com)
  • Wide thermal range of cold agglutinin is more clinically significant than concentration (titre). (transfusion.ca)
  • We sought to determine whether a negative DAT using anti-human complement (anti-C3) rules out elevated cold agglutinin (CA) titers and the diagnosis of CAD. (ovid.com)
  • An abnormal (positive) result means there were agglutinins in your blood sample. (medlineplus.gov)
  • This test detects and measures the amount of cold agglutinins in the blood. (labtestsonline.org)
  • As a result, the blood of a host applied to a diagnostic kit causes the aggregation of the pathogenic particles due to the antigen-agglutinin interaction. (wikipedia.org)
  • A cold agglutinins blood test is done to check for conditions that cause the body to make certain types of antibodies called cold agglutinins. (healthwise.net)
  • Healthy people generally have low levels of cold agglutinins in their blood. (healthwise.net)
  • Sometimes high levels of cold agglutinins can destroy red blood cells throughout the body. (healthwise.net)
  • Over half of people with pneumonia caused by mycoplasma develop an increase in cold agglutinin levels in their blood within a week of being infected. (healthwise.net)
  • If clumped red blood cells (called a Rouleaux formation) are seen on a complete blood count (CBC) test, your doctor may order a cold agglutinins test to see whether high cold agglutinin levels are present. (healthwise.net)
  • In this report we describe a rare complication caused by the very high concentration in the recipient of cold agglutinins and the activation of the complement system, responsible for red blood cell lysis and consequent fatal cardiovascular shock. (biomedcentral.com)