Substances, usually of biological origin, that cause cells or other organic particles to aggregate and stick to each other. They include those ANTIBODIES which cause aggregation or agglutination of particulate or insoluble ANTIGENS.
Lectins purified from the germinating seeds of common wheat (Triticum vulgare); these bind to certain carbohydrate moieties on cell surface glycoproteins and are used to identify certain cell populations and inhibit or promote some immunological or physiological activities. There are at least two isoforms of this lectin.
Lectin purified from peanuts (ARACHIS HYPOGAEA). It binds to poorly differentiated cells and terminally differentiated cells and is used in cell separation techniques.
Protein or glycoprotein substances of plant origin that bind to sugar moieties in cell walls or membranes. Some carbohydrate-metabolizing proteins (ENZYMES) from PLANTS also bind to carbohydrates, however they are not considered lectins. Many plant lectins change the physiology of the membrane of BLOOD CELLS to cause agglutination, mitosis, or other biochemical changes. They may play a role in plant defense mechanisms.
Proteins that share the common characteristic of binding to carbohydrates. Some ANTIBODIES and carbohydrate-metabolizing proteins (ENZYMES) also bind to carbohydrates, however they are not considered lectins. PLANT LECTINS are carbohydrate-binding proteins that have been primarily identified by their hemagglutinating activity (HEMAGGLUTININS). However, a variety of lectins occur in animal species where they serve diverse array of functions through specific carbohydrate recognition.
Glycoprotein molecules on the surface of B- and T-lymphocytes, that react with molecules of antilymphocyte sera, lectins, and other agents which induce blast transformation of lymphocytes.
Abnormal immunoglobulins, especially IGG or IGM, that precipitate spontaneously when SERUM is cooled below 37 degrees Celsius. It is characteristic of CRYOGLOBULINEMIA.
The clumping together of suspended material resulting from the action of AGGLUTININS.
Common name for Ricinus communis, a species in the family EUPHORBIACEAE. It is the source of CASTOR OIL.
Tests that are dependent on the clumping of cells, microorganisms, or particles when mixed with specific antiserum. (From Stedman, 26th ed)
A plant genus of the family EUPHORBIACEAE, order Euphorbiales, subclass Rosidae. The seed of Ricinus communis L. is the CASTOR BEAN which is the source of CASTOR OIL; RICIN; and other lectins.
A plant genus in the family LILIACEAE (sometimes classified as Amaryllidaceae). Galanthus nivalis L. is the source of GALANTHAMINE.
A MANNOSE/GLUCOSE binding lectin isolated from the jack bean (Canavalia ensiformis). It is a potent mitogen used to stimulate cell proliferation in lymphocytes, primarily T-lymphocyte, cultures.
A plant species of the family FABACEAE that yields edible seeds, the familiar peanuts, which contain protein, oil and lectins.
The N-acetyl derivative of galactosamine.
The aggregation of ERYTHROCYTES by AGGLUTININS, including antibodies, lectins, and viral proteins (HEMAGGLUTINATION, VIRAL).
Acquired hemolytic anemia due to the presence of AUTOANTIBODIES which agglutinate or lyse the patient's own RED BLOOD CELLS.
The largest class of organic compounds, including STARCH; GLYCOGEN; CELLULOSE; POLYSACCHARIDES; and simple MONOSACCHARIDES. Carbohydrates are composed of carbon, hydrogen, and oxygen in a ratio of Cn(H2O)n.
Cell surface receptors that bind to ACETYLGLUCOSAMINE.
Sensitive tests to measure certain antigens, antibodies, or viruses, using their ability to agglutinate certain erythrocytes. (From Stedman, 26th ed)
Carbohydrates covalently linked to a nonsugar moiety (lipids or proteins). The major glycoconjugates are glycoproteins, glycopeptides, peptidoglycans, glycolipids, and lipopolysaccharides. (From Biochemical Nomenclature and Related Documents, 2d ed; From Principles of Biochemistry, 2d ed)
The N-acetyl derivative of glucosamine.
A toxic lectin from the seeds of jequirity, Abrus precatorius L. Very active poison. Five different proteins have so far been isolated: Abrus agglutinin, the component responsible for: hemagglutinating activity, & abrins a-d, the toxic principals each consisting of two peptide chains are held together by disulfide bonds.
Proteins which are present in or isolated from SOYBEANS.
A plant species of the genus DATURA, family SOLANACEAE, that contains TROPANES and other SOLANACEOUS ALKALOIDS.
Conjugated protein-carbohydrate compounds including mucins, mucoid, and amyloid glycoproteins.
The sequence of carbohydrates within POLYSACCHARIDES; GLYCOPROTEINS; and GLYCOLIPIDS.
N-Glycosidases that remove adenines from RIBOSOMAL RNA, depurinating the conserved alpha-sarcin loop of 28S RIBOSOMAL RNA. They often consist of a toxic A subunit and a binding lectin B subunit. They may be considered as PROTEIN SYNTHESIS INHIBITORS. They are found in many PLANTS and have cytotoxic and antiviral activity.
Glycoprotein moieties on the surfaces of cell membranes that bind concanavalin A selectively; the number and location of the sites depends on the type and condition of the cell.
A chromatographic technique that utilizes the ability of biological molecules to bind to certain ligands specifically and reversibly. It is used in protein biochemistry. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Agents that cause agglutination of red blood cells. They include antibodies, blood group antigens, lectins, autoimmune factors, bacterial, viral, or parasitic blood agglutinins, etc.
Ribosome inactivating proteins consisting of two polypeptide chains, the toxic A subunit and a lectin B subunit, linked by disulfide bridges. The lectin portion binds to cell surfaces and facilitates transport into the ENDOPLASMIC RETICULUM.
A blood group related both to the ABO and P systems that includes several different antigens found in most people on erythrocytes, in milk, and in saliva. The antibodies react only at low temperatures.
An enzyme that catalyzes the hydrolysis of alpha-2,3, alpha-2,6-, and alpha-2,8-glycosidic linkages (at a decreasing rate, respectively) of terminal sialic residues in oligosaccharides, glycoproteins, glycolipids, colominic acid, and synthetic substrate. (From Enzyme Nomenclature, 1992)
A group of naturally occurring N-and O-acyl derivatives of the deoxyamino sugar neuraminic acid. They are ubiquitously distributed in many tissues.
Agglutination of spermatozoa by antibodies or autoantibodies.
The characteristic 3-dimensional shape of a carbohydrate.
Carbohydrates consisting of between two (DISACCHARIDES) and ten MONOSACCHARIDES connected by either an alpha- or beta-glycosidic link. They are found throughout nature in both the free and bound form.
An aldohexose that occurs naturally in the D-form in lactose, cerebrosides, gangliosides, and mucoproteins. Deficiency of galactosyl-1-phosphate uridyltransferase (GALACTOSE-1-PHOSPHATE URIDYL-TRANSFERASE DEFICIENCY DISEASE) causes an error in galactose metabolism called GALACTOSEMIA, resulting in elevations of galactose in the blood.
7-Hydroxycoumarins. Substances present in many plants, especially umbelliferae. Umbelliferones are used in sunscreen preparations and may be mutagenic. Their derivatives are used in liver therapy, as reagents, plant growth factors, sunscreens, insecticides, parasiticides, choleretics, spasmolytics, etc.
An N-acyl derivative of neuraminic acid. N-acetylneuraminic acid occurs in many polysaccharides, glycoproteins, and glycolipids in animals and bacteria. (From Dorland, 28th ed, p1518)
Cellular processes in biosynthesis (anabolism) and degradation (catabolism) of CARBOHYDRATES.
Study of intracellular distribution of chemicals, reaction sites, enzymes, etc., by means of staining reactions, radioactive isotope uptake, selective metal distribution in electron microscopy, or other methods.
A plant genus of the family FABACEAE. Members contain ABRIN.
The chemical or biochemical addition of carbohydrate or glycosyl groups to other chemicals, especially peptides or proteins. Glycosyl transferases are used in this biochemical reaction.
A polysaccharide-producing species of STREPTOCOCCUS isolated from human dental plaque.
The clear, viscous fluid secreted by the SALIVARY GLANDS and mucous glands of the mouth. It contains MUCINS, water, organic salts, and ptylin.
Antibodies which elicit IMMUNOPRECIPITATION when combined with antigen.
Mannosides formed by the reaction of the hydroxyl group on the anomeric carbon atom of mannose with methyl alcohol. They include both alpha- and beta-methylmannosides.
Electrophoresis in which a polyacrylamide gel is used as the diffusion medium.
The lectin wheatgerm agglutinin conjugated to the enzyme HORSERADISH PEROXIDASE. It is widely used for tracing neural pathways.
Carbohydrate antigens expressed by malignant tissue. They are useful as tumor markers and are measured in the serum by means of a radioimmunoassay employing monoclonal antibodies.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
A coumarin derivative possessing properties as a spasmolytic, choleretic and light-protective agent. It is also used in ANALYTICAL CHEMISTRY TECHNIQUES for the determination of NITRIC ACID.
Red blood cells. Mature erythrocytes are non-nucleated, biconcave disks containing HEMOGLOBIN whose function is to transport OXYGEN.
Plants or plant parts which are harmful to man or other animals.
Simple sugars, carbohydrates which cannot be decomposed by hydrolysis. They are colorless crystalline substances with a sweet taste and have the same general formula CnH2nOn. (From Dorland, 28th ed)
The lipid- and protein-containing, selectively permeable membrane that surrounds the cytoplasm in prokaryotic and eukaryotic cells.
A plant genus of the family POACEAE that is the source of EDIBLE GRAIN. A hybrid with rye (SECALE CEREALE) is called TRITICALE. The seed is ground into FLOUR and used to make BREAD, and is the source of WHEAT GERM AGGLUTININS.
Sets of cell surface antigens located on BLOOD CELLS. They are usually membrane GLYCOPROTEINS or GLYCOLIPIDS that are antigenically distinguished by their carbohydrate moieties.
A protein phytotoxin from the seeds of Ricinus communis, the castor oil plant. It agglutinates cells, is proteolytic, and causes lethal inflammation and hemorrhage if taken internally.
A hexose or fermentable monosaccharide and isomer of glucose from manna, the ash Fraxinus ornus and related plants. (From Grant & Hackh's Chemical Dictionary, 5th ed & Random House Unabridged Dictionary, 2d ed)
The parts of a macromolecule that directly participate in its specific combination with another molecule.
The sum of the weight of all the atoms in a molecule.
Glycosides formed by the reaction of the hydroxyl group on the anomeric carbon atom of galactose with an alcohol to form an acetal. They include both alpha- and beta-galactosides.
Oligosaccharides containing two monosaccharide units linked by a glycosidic bond.
A genus of filamentous CYANOBACTERIA in the order Oscillatoriales. It is commonly found in freshwater environments, especially hot springs.
A genus GREEN ALGAE in the order VOLVOCIDA. It consists of solitary biflagellated organisms common in fresh water and damp soil.
Serum that contains antibodies. It is obtained from an animal that has been immunized either by ANTIGEN injection or infection with microorganisms containing the antigen.
Parasitic plants that form a bushy growth on branches of host trees which are in the order Santalales. It includes the Christmas mistletoe family (VISCACEAE), the showy mistletoe family (LORANTHACEAE) and the catkin mistletoe family (Eremolepidaceae). The composition of toxins, lectins, tyramine, phenethylamines, and other compounds may be affected by the host.
Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).
Fluorescent probe capable of being conjugated to tissue and proteins. It is used as a label in fluorescent antibody staining procedures as well as protein- and amino acid-binding techniques.
A condition of inadequate circulating red blood cells (ANEMIA) or insufficient HEMOGLOBIN due to premature destruction of red blood cells (ERYTHROCYTES).
The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.
The cap-like structure covering the anterior portion of SPERM HEAD. Acrosome, derived from LYSOSOMES, is a membrane-bound organelle that contains the required hydrolytic and proteolytic enzymes necessary for sperm penetration of the egg in FERTILIZATION.
A class of immunoglobulin bearing mu chains (IMMUNOGLOBULIN MU-CHAINS). IgM can fix COMPLEMENT. The name comes from its high molecular weight and originally being called a macroglobulin.
A test to detect non-agglutinating ANTIBODIES against ERYTHROCYTES by use of anti-antibodies (the Coombs' reagent.) The direct test is applied to freshly drawn blood to detect antibody bound to circulating red cells. The indirect test is applied to serum to detect the presence of antibodies that can bind to red blood cells.
Serum globulins with high molecular weight. (Dorland, 28th ed)
The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.
A genus of chiefly Eurasian and African land snails including the principal edible snails as well as several pests of cultivated plants.
Specific, characterizable, poisonous chemicals, often PROTEINS, with specific biological properties, including immunogenicity, produced by microbes, higher plants (PLANTS, TOXIC), or ANIMALS.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
Proteins which contain carbohydrate groups attached covalently to the polypeptide chain. The protein moiety is the predominant group with the carbohydrate making up only a small percentage of the total weight.
Serologic tests in which a known quantity of antigen is added to the serum prior to the addition of a red cell suspension. Reaction result is expressed as the smallest amount of antigen which causes complete inhibition of hemagglutination.
Local surface sites on antibodies which react with antigen determinant sites on antigens (EPITOPES.) They are formed from parts of the variable regions of FAB FRAGMENTS.
Changes that occur to liberate the enzymes of the ACROSOME of a sperm (SPERMATOZOA). Acrosome reaction allows the sperm to penetrate the ZONA PELLUCIDA and enter the OVUM during FERTILIZATION.
An infraorder of CRUSTACEA, in the order DECAPODA comprising the hermit crabs and characterized by a small fifth pair of legs.
A plant genus of the family FABACEAE (sometimes classified as Papilionaceae). Members contain LECTINS.
A plant genus of the family ARACEAE. It has a stemless, tuberous root.
A disaccharide of GLUCOSE and GALACTOSE in human and cow milk. It is used in pharmacy for tablets, in medicine as a nutrient, and in industry.
Microscopy using an electron beam, instead of light, to visualize the sample, thereby allowing much greater magnification. The interactions of ELECTRONS with specimens are used to provide information about the fine structure of that specimen. In TRANSMISSION ELECTRON MICROSCOPY the reactions of the electrons that are transmitted through the specimen are imaged. In SCANNING ELECTRON MICROSCOPY an electron beam falls at a non-normal angle on the specimen and the image is derived from the reactions occurring above the plane of the specimen.
A strong oxidizing agent.
A trypanosome found in the blood of adult rats and transmitted by the rat flea. It is generally non-pathogenic in adult rats but can cause lethal infection in suckling rats.
Chromatography on non-ionic gels without regard to the mechanism of solute discrimination.
A subclass of anhydrides with the general structure of dihydrofurandione. They can be substituted on any carbon atom. They modify and inhibit proteins and enzymes and are used in the acylation of amino- and hydroxyl groups.
Plants whose roots, leaves, seeds, bark, or other constituent parts possess therapeutic, tonic, purgative, curative or other pharmacologic attributes, when administered to man or animals.
A linear polysaccharide of beta-1->4 linked units of ACETYLGLUCOSAMINE. It is the second most abundant biopolymer on earth, found especially in INSECTS and FUNGI. When deacetylated it is called CHITOSAN.
A genus of tiny mushrooms in the family Tricholomataceae. They help break down the decaying organic matter of the forest floor.
A serovar of the bacterial species LEPTOSPIRA INTERROGANS, whose natural host is DOGS where disease is characterized by GASTROENTERITIS, and INTERSTITIAL NEPHRITIS.
The major human blood type system which depends on the presence or absence of two antigens A and B. Type O occurs when neither A nor B is present and AB when both are present. A and B are genetic factors that determine the presence of enzymes for the synthesis of certain glycoproteins mainly in the red cell membrane.
A chemical reagent that reacts with and modifies chemically the tryptophan portion of protein molecules. Used for 'active site' enzyme studies and other protein studies. Sometimes referred to as Koshland's reagent.
The marking of biological material with a dye or other reagent for the purpose of identifying and quantitating components of tissues, cells or their extracts.
High molecular weight mucoproteins that protect the surface of EPITHELIAL CELLS by providing a barrier to particulate matter and microorganisms. Membrane-anchored mucins may have additional roles concerned with protein interactions at the cell surface.
An annual legume. The SEEDS of this plant are edible and used to produce a variety of SOY FOODS.
A basic science concerned with the composition, structure, and properties of matter; and the reactions that occur between substances and the associated energy exchange.
An absence of warmth or heat or a temperature notably below an accustomed norm.

Some leptospira agglutinins detected in domestic animals in British Columbia. (1/437)

During a period of six years 7,555 bovine sera, 421 canine sera, 251 porcine sera and 135 equine sera were tested for agglutinins to Leptospira interrogans serotypes canicola, grippotyphosa, hardjo, icterohemorrhagiae, pomona and sejroe. The bovine sera reacted predominantly with hardjo and/or sejroe at a rate of 15% compared to 3.5% with pomona. Breeding or abortion problems were associated with pomona but not with sejroe/hardjo agglutinins. The canine sera reacted to canicola (9.9%y and icterohemorrhagiae (5.4%), tcted predominantly with canicola (8.9%) and icterohemorrhagiae (8.1%).  (+info)

Platelet high affinity low density lipoprotein binding and import of lipoprotein derived phospholipids. (2/437)

The binding of low density lipoprotein (LDL) to the platelet cell membrane could facilitate the transfer of phospholipids from LDL to the platelets. A polyclonal antibody against the platelet glycoproteins IIb/IIIa inhibited the high affinity binding of 125I-LDL by up to 80%. The transfer of pyrene (py)-labeled sphingomyelin (SM), phosphatidylcholine and phosphatidylethanolamine from LDL to the platelets was unaffected by the antibody. The lectin wheat germ agglutinin (WGA) reduced the binding of 125I-LDL to the platelets by approximately 80%. In contrast, the lectin stimulated the transfer of SM from LDL into the platelets by about three-fold. WGA also specifically augmented the transfer of py-SM between lipid vesicles and the platelets, the stimulation being abolished in the presence of N-acetylglucosamine. Dextran sulfate (DS) increased the specific binding of 125I-LDL to the platelets by up to 2.8-fold. On the other hand, the import of LDL-derived py-phospholipids was unaffected by DS. Together, the results indicate that the phospholipid transfer from LDL to the platelets is independent of the high affinity LDL binding to the platelets and is specifically stimulated by WGA. Thus, the interactions of platelets with LDL phospholipids differ markedly from those with the apoprotein components of the lipoproteins.  (+info)

Role of nonagglutinating antibody in the protracted immunity of vaccinated mice to Pseudomonas aeruginosa infection. (3/437)

Effective immunization against infection with Pseudomonas aeruginosa is difficult to evaluate because agglutinin levels decline rapidly. Because fractionation of hyperimmune sera often yields more specific antibody than can be accounted for by direct agglutination tests, an immunoglobulin-specific assay based on antiglobulin augmentation was used to characterize antibody responses of C3H/HeJ mice vaccinated with P. aeruginosa type 2 lipopolysaccharide. Nonagglutinating antibodies, initially detected at 2 weeks post-primary vaccination, were predominantly immunoglobulin G after 5 weeks, and they remained elevated at levels usually 32-fold higher than the direct titer throughout the 4-month study period. The sequential production of immunoglobulin M, then immunoglobulin G, followed that found in orthodox immunological responses. Sera that contained nonagglutinating antibodies but not direct agglutinins (14 to 16 weeks) enhanced phagocytosis of P. aeruginosa type 2 by macrophages from unimmunized mice and passively immunized mice against lethal challenge doses; bactericidal activity of these sera was not demonstrated in the presence or absence of complement. When challenged with 1, 10, and 100 50% lethal doses at 16 weeks, survival rates of actively immunized mice were significantly higher than those of unvaccinated mice (P < 0.001). Thus, at a time when no direct agglutinins were detectable, the augmented system detected nonagglutinating antibodies that could confer protracted resistance in vaccinated mice to pseudomonas infection.  (+info)

Expression of DMBT1, a candidate tumor suppressor gene, is frequently lost in lung cancer. (4/437)

DMBT1 is a candidate tumor suppressor gene located at 10q25.3-26.1. Homozygous deletion of the gene was found in a subset of medulloblastoma and glioblastoma multiforme; lack of expression was noted in the majority of these tumors. In adult tissues, DMBT1 is highly expressed only in lung and small intestine tissues, indicating its important role in these organs. By analyzing lung cancer cell lines and primary lung tumors using reverse transcription-PCR, we found that 100% (20 of 20) of small cell lung cancer (SCLC) cell lines and 43% (6 of 14) of non-small cell lung cancer (NSCLC) cell lines lacked DMBT1 expression. Furthermore, 45% (9 of 20) of the primary NSCLCs exhibited a markedly low level of gene expression compared with corresponding normal lung tissues, indicating that lack of gene expression also occurs in primary lung cancers. To determine the potential mechanisms for lack of DMBT1 expression in lung cancer, we analyzed tumor cell lines for potential intragenic homozygous deletions of the gene and found such homozygous deletions in 10% (4 of 40) of SCLC cell lines but in none of 14 NSCLC cell lines. Moreover, the loss of expression could not be rescued by treatment with a demethylation agent (5-azacytidine) in two NSCLC cell lines lacking DMBT1 expression, suggesting that de novo methylation of the promoter region of the gene is unlikely to play a role in inactivation of the gene. We then sequenced the whole coding region of DMBT1 in 8 NSCLC cell lines that expressed DMBT1 and 20 primary NSCLCs. A potential point mutation at codon 52 was detected in a NSCLC cell line and resulted in an amino acid change from serine to tryptophan. Three common polymorphisms were also detected in tissues analyzed. Our data demonstrate that DMBT1 expression is frequently lost in lung cancer due to gene deletion and to other not yet identified mechanisms, suggesting that inactivation of DMBT1 may play an important role in lung tumorigenesis.  (+info)

Complement receptor 1 (CD35) on human reticulocytes: normal expression in systemic lupus erythematosus and HIV-infected patients. (5/437)

The low levels of complement receptor 1 (CR1) on erythrocytes in autoimmune diseases and AIDS may be due to accelerated loss in the circulation, or to a diminished expression of CR1 on the red cell lineage. Therefore, we analyzed the expression of CR1 on reticulocytes (R) vs erythrocytes (E). Healthy subjects had a significant higher CR1 number per cell on R (919 +/- 99 CR1/cell) than on E (279 +/- 30 CR1/cell, n = 23), which corresponded to a 3. 5- +/- 1.3-fold loss of CR1. This intravascular loss was confirmed by FACS analysis, which showed that all R expressed CR1, whereas a large fraction of E was negative. The systemic lupus erythematosus (SLE), HIV-infected, and cold hemolytic Ab disease (CHAD) patients had a CR1 number on R identical to the healthy subjects, contrasting with a lower CR1 on their E. The data indicated a significantly higher loss of CR1 in the three diseases, i.e., 7.0- +/- 3.8-, 6.1- +/- 2.9-, and 9.6- +/- 5.6-fold, respectively. The intravascular loss was best exemplified in a patient with factor I deficiency whose CR1 dropped from 520 CR1/R to 28 CR1/E, i.e., 18.6-fold loss. In one SLE patient and in the factor I-deficient patient, the FACS data were consistent with a loss of CR1 already on some R. In conclusion, CR1 is lost progressively from normal E during in vivo aging so that old E are almost devoid of CR1. The low CR1 of RBC in autoimmune diseases and HIV-infection is due to a loss occurring in the circulation by an active process that remains to be defined.  (+info)

Hensin, the polarity reversal protein, is encoded by DMBT1, a gene frequently deleted in malignant gliomas. (6/437)

The band 3 anion exchanger is located in the apical membrane of a beta-intercalated clonal cell line, whereas the vacuolar H(+)-ATPase is present in the basolateral membrane. When these cells were seeded at confluent density, they converted to an alpha-phenotype, localizing each of these proteins to the opposite cell membrane domain. The reversal of polarity is induced by hensin, a 230-kDa extracellular matrix protein. Rabbit kidney hensin is a multidomain protein composed of eight SRCR ("scavenger receptor, cysteine rich"), two CUB ("C1r/C1s Uegf Bmp1"), and one ZP ("zona pellucida") domain. Other proteins known to have these domains include CRP-ductin, a cDNA expressed at high levels in mouse intestine (8 SRCR, 5 CUB, 1 ZP), ebnerin, a protein cloned from a rat taste bud library (4 SRCR, 3 CUB, 1 ZP), and DMBT1, a sequence in human chromosome 10q25-26 frequently deleted in malignant gliomas (9 SRCR, 2 CUB, 1 ZP). Rabbit and mouse hensin genomic clones contained a new SRCR that was not found in hensin cDNA but was homologous to the first SRCR domain in DMBT1. Furthermore, the 3'-untranslated regions and the signal peptide of hensin were homologous to those of DMBT1. Mouse genomic hensin was localized to chromosome 7 band F4, which is syntenic to human 10q25-26. These data suggest that hensin and DMBT1 are alternatively spliced forms of the same gene. The analysis of mouse hensin bacterial artificial chromosome (BAC) genomic clone by sequencing and Southern hybridization revealed that the gene also likely encodes CRP-ductin. A new antibody against the mouse SRCR1 domain recognized a protein in the mouse and rabbit brain but not in the immortalized cell line or kidney, whereas an antibody to SRCR6 and SRCR7 domains which are present in all the transcripts, recognized proteins in intestine, kidney, and brain from several species. The most likely interpretation of these data is that one gene produces at least three transcripts, namely, hensin, DMBT1, and CRP-ductin. Hensin may participate in determining the polarized phenotype of other epithelia and brain cells.  (+info)

The extracellular matrix in the mouse brain: its reactions to endo-alpha-N-acetylgalactosaminidase and certain other enzymes. (7/437)

As our previous studies have indicated, the cingulate cortex of the adult mouse brain contains many neurons with rich cell surface glycoproteins which are linked by collagenous ligands to perineuronal proteoglycans. The present study demonstrated that exclusive incubation with endo-alpha-N-acetylgalactosaminidase abolished the lectin Vicia villosa or Wisteria floribunda agglutinin (VVA or WFA) labeling of the nerve cell surface glycoproteins, while it neither interfered with the cationic iron colloid or aldehyde fuchsin stainings of the perineuronal proteoglycans nor abolished the Gomori's ammoniacal silver impregnation of the collagenous ligands. Double incubations with endo-alpha-N-acetylgalactosaminidase and collagenase did not eliminate the lectin VVA or WFA labeling of the nerve cell surface glycoproteins, though they did eliminate the cationic iron colloid and aldehyde fuchsin stainings of the perineuronal proteoglycans as well as the Gomori's ammoniacal silver impregnation of the collagenous ligands. Triple incubations with endo-alpha-N-acetylgalactosaminidase, collagenase, and endo-alpha-N-acetylgalactosaminidase abolished the lectin VVA or WFA labeling of the nerve cell surface glycoproteins, and also eliminated the cationic iron colloid and aldehyde fuchsin stainings of the perineuronal proteoglycans and the Gomori's ammoniacal silver impregnation of the collagenous ligands. These findings indicate that: the nerve cell surface glycoproteins or their terminal N-acetylgalactosamines are digested by endo-alpha-N-acetylgalactosaminidase; these galactosamines associated with the collagenous ligands or perineuronal proteoglycans are not digested by endo-alpha-N-acetylgalactosaminidase; and the terminal N-acetylgalactosamines newly exposed by collagenase incubation are digested by this galactosaminidase. It was further demonstrated that hyaluronidase incubation neither digests the collagenous ligands nor revives the lectin VVA or WFA labeling of the nerve cell surface proteoglycans.  (+info)

Purification and characterization of a natural agglutinin from the serum of the hermit crab Diogenes affinis. (8/437)

A natural agglutinin from the serum of the hermit crab Diogenes affinis was purified to homogeneity by a single-step affinity chromatography using N-acetylglucosamine-coupled Sepharose 6B. The purified serum agglutinin (PSA) showed a strong affinity for rat RBC, and its hemagglutinating (HA) activity was specifically dependent on Ca2+ and reversibly sensitive to EDTA. PSA in active form has a molecular mass estimate of 185 kDa and is composed of four non-identical subunits (51, 49, 42 and 39 kDa) cross-linked by interchain disulfide bonds. The homogeneity of PSA was corroborated by immunodiffusion and immunoelectrophoretic analyses using rabbit antiserum raised against the agglutinin. The antibodies in this antiserum appear to be specific for RBC-binding sites of the agglutinin molecules as revealed by the ability of the antiserum to neutralize HA activities of both whole serum and PSA of D. affinis. In HA-inhibition assays performed with several carbohydrates and glycoproteins, PSA showed a distinct and unique specificity for acetyl group in carbohydrates independently of the presence of this group on C-2 or C-5 and its stereochemical arrangement in the axial or equatorial orientation. Besides, this agglutinin appears to recognize the terminal N- and O- acetyl groups in the oligosaccharide chain of glycoconjugates. The HA activity of D. affinis agglutinin was also susceptible to inhibition by lipopolysaccharides from diverse gram-negative bacteria, which might indicate a significant in vivo role of this humoral agglutinin in the host immune response against bacterial infections.  (+info)

Autoimmune hemolytic anemia (AIHA) is a specific type of hemolytic anemia that occurs when the immune system mistakenly attacks and destroys red blood cells. This can happen due to various underlying causes such as infections, certain medications, and some types of cancer.

In autoimmune hemolytic anemia, the immune system produces antibodies that coat the surface of red blood cells and mark them for destruction by other immune cells called complement proteins. This leads to the premature destruction of red blood cells in the spleen, liver, and other organs.

Symptoms of autoimmune hemolytic anemia can include fatigue, weakness, shortness of breath, jaundice (yellowing of the skin and eyes), dark urine, and a pale or yellowish complexion. Treatment options for AIHA depend on the underlying cause of the disorder, but may include medications to suppress the immune system, plasmapheresis to remove antibodies from the blood, and in severe cases, splenectomy (removal of the spleen) or bone marrow transplantation.

In summary, autoimmune hemolytic anemia is a type of hemolytic anemia that occurs when the immune system mistakenly attacks and destroys red blood cells, leading to premature destruction of red blood cells and various symptoms such as fatigue, weakness, and jaundice. Treatment options depend on the underlying cause of the disorder and may include medications, plasmapheresis, and in severe cases, splenectomy or bone marrow transplantation.

Symptoms of hemolytic anemia may include fatigue, weakness, shortness of breath, dizziness, headaches, and pale or yellowish skin. Treatment options depend on the underlying cause but may include blood transfusions, medication to suppress the immune system, antibiotics for infections, and removal of the spleen (splenectomy) in severe cases.

Prevention strategies for hemolytic anemia include avoiding triggers such as certain medications or infections, maintaining good hygiene practices, and seeking early medical attention if symptoms persist or worsen over time.

It is important to note that while hemolytic anemia can be managed with proper treatment, it may not be curable in all cases, and ongoing monitoring and care are necessary to prevent complications and improve quality of life.

... might also be associated with diseases of which the most common is an autoimmune disease known as cold agglutinin ... Agglutinins can also be any substance other than antibodies, such as sugar-binding protein lectins. When an agglutinin is added ... In cold agglutinin disease, the body produces agglutinins or antibodies that coagulate erythrocytes and lyse them at room ... individuals with cold agglutinin disease develop a form of anemia. A body might produce agglutinins to attack the erythrocytes ...
Soybean agglutinins (SBA) also known as soy bean lectins (SBL) are lectins found in soybeans. It is a family of similar legume ... Consumption of soybean agglutinin resulted in a depletion of lipid and an overgrowth of small intestine and pancreas in rats. ... Li, Z; Li, D; Qiao, S; Zhu, X; Huang, C (Aug 2003). "Anti-nutritional effects of a moderate dose of soybean agglutinin in the ... "Vector Labs: Soybean Agglutinin (SBA)". Archived from the original on 2014-11-02. Retrieved 2014-11-02. "Cornell University ...
... (PNA) is plant lectin protein derived from the fruits of Arachis hypogaea. Peanut agglutinin may also be ... Available Structures of peanut agglutinin Because peanut agglutinin specifically binds a particular carbohydrate sequence it ... Peanut agglutinin activity is inhibited by lactose and galactose which compete for the binding site. Other uses include: Potent ... The name "peanut agglutinin" originates from its ability to stick together (agglutinate) cells, such as neuraminidase-treated ...
... (WGA) is a lectin that protects wheat (Triticum) from insects, yeast and bacteria. An agglutinin protein ... Ohno J, Tajima Y, Utsumi N (October 1986). "Binding of wheat germ agglutinin in the matrix of rat tracheal cartilage". The ... Emde B, Heinen A, Gödecke A, Bottermann K (December 2014). "Wheat germ agglutinin staining as a suitable method for detection ... Proteopedia: 2uvo - High resolution crystal structure of Wheat Germ Agglutinin in complex with N-acetyl-D-glucosamine ...
... was first described in 1957. Symptoms of cold agglutinin disease (CAD) are often triggered or made ... Removing the spleen is not recommended for cold agglutinin disease. In addition, because severe cold agglutinin disease ... Individuals with cold agglutinin disease present with signs and symptoms of hemolytic anemia. Those with secondary agglutinin ... "Cold agglutinin disease". Orphanet. Archived from the original on 2015-10-06. Retrieved 2019-02-09. Cold Agglutinin Disease at ...
Secondary cold agglutinin syndrome refers to cold agglutinin disease that is identified to be caused by viral infection, ... Cold agglutinins can cause two pathological conditions, that are, primary cold agglutinin disease (CAD) and secondary cold ... agglutinin syndrome (CAS), both of which are sole two subtypes of cold agglutinin disease. Primary cold agglutinin disease is ... Cold agglutinins (CA) are autoantibodies that agglutinate RBCs with a temperature optimum of 3-4 °C but may also act in a ...
The antigen on red blood cells that is bound by these cold agglutinins is known as the I antigen. Feizi worked with Sen-itiroh ... Almost one third of patients who suffer from atypical pneumonia develop cold agglutinins in their blood, which are misdirected ... Feizi, Ten (1969). Cold agglutinins and mycoplasma pneumoniae (Thesis). OCLC 926243918. "Dr. Ten Feizi wins 2014 Rosalind ... Her early research considered cold agglutinins, sensitive, misdirected antibodies that build up following mycoplasma pneumoniae ...
Anti-B agglutinins such as anti-BCJ and anti-BLD separated from Charybdis japonica and Lymantria dispar, respectively, are of ... Its seeds contain high activity of soybean lectins (soybean agglutinin or SBA). Long before a deeper understanding of their ... Boyd, W.C.; Shapleigh, E. (1954). "Specific precipitation activity of plant agglutinins (lectins)". Science. 119 (3091): 419. ...
Pemberton R.T. (1994). "Agglutinins (lectins) from some British higher fungi". Mycological Research. 98 (3): 277-90. doi: ...
Wilson L (1954). "Sperm agglutinins in human semen and blood". Proceedings of the Society for Experimental Biology and Medicine ...
The diagnosis of cold agglutinin disease is confirmed with an elevated cold agglutinin titer. A bone marrow biopsy is used in ... Steroids are not indicated in the treatment of cold agglutinin disease due to low response rates. Cases of cold agglutinin ... Primary cold agglutinin disease Secondary cold agglutinin syndrome Associated with malignant disease Acute, transient, ... In cold agglutinin disease, the monospecific DAT is by definition positive for the compliment molecule C3d but IgM may be ...
... and Marasmius oreades agglutinin - MOA. These four toxic lectins bind to specific glycan structures found in H. controtus. Some ...
Hallman, Frances A. (1935). "Streptococcal agglutinins and antistreptolysins in rheumatoid (atrophic) arthritis" (PDF). The ...
A receptor, Peanut agglutinin receptor(PNAR)). This fact gave rise to the idea that spontaneous autoimmunity may result when ...
... a plant seed lectin and agglutinin from Helianthus tuberosus (Jerusalem artichoke). Agglutinin from Calystegia sepium (Hedge ... Proteins containing this domain include: Jacalin, a tetrameric plant seed lectin and agglutinin from Artocarpus heterophyllus ( ... Lectin MPA, a tetrameric plant seed lectin and agglutinin from Maclura pomifera (Osage orange). Heltuba lectin, ... which binds to the T-antigen and acts as an agglutinin. This domain is found in 1 to 6 copies in lectins. The domain is also ...
"Susceptibility to Pneumococcus Infection as Measured by Species-Specific Agglutinins". The Journal of Immunology. 28 (1): 55-74 ...
Coombs RR, Mourant AE, Race RR (1945). "Detection of weak and "incomplete" Rh agglutinins: a new test". Lancet. 246 (6358): 15- ...
Handelsman J, Ugalde RA, Brill WJ (March 1984). "Rhizobium meliloti competitiveness and the alfalfa agglutinin". Journal of ...
Pathologic cold agglutinins occur at titers over 1:1000 and react at 28-31 °C and sometimes at 37 °C. Cold agglutinin disease ... In chronic cold agglutinin disease, the patient is more symptomatic during the colder months. Cold agglutinin mediated ... Translocation (8;22) has also been reported in association with cold agglutinin disease. Transplantation: Cold agglutinin- ... Primary cold agglutinin disease Secondary cold agglutinin syndrome Associated with malignant disease Acute, transient, ...
Hao, Guijie (January 2016). "Biological Characteristics of Serum Agglutinin from Portunus trituberculatus". Agricultural ...
"Cold Agglutinin Disease: Overview - eMedicine Pediatrics: General Medicine". Retrieved 2009-02-07. "Paroxysmal cold ...
Immunocytochemical Localization of Wheat Germ Agglutinin in Wheat. The Journal of cell Biology, Vol 92, No.3 Retrieved November ...
"A new test for the detection of weak and incomplete Rh agglutinins". British Journal of Experimental Pathology. 26: 255-66. PMC ...
A new test for the detection of weak and incomplete Rh agglutinins. Br J Exp Pathol 1945;26:255 Chown B, Lewis M, Kaita K ( ...
Partial List: Willims Jr, R. C.; Kunkel, H. G.; Capra, J. D. (1968). "Antigenic specificities related to the cold agglutinin ... "Nucleotide sequence analysis of the V regions of two IgM cold agglutinins. Evidence that the VH4-21 gene segment is responsible ...
Coombs RR, Mourant AE, Race RR (1945). "A new test for the detection of weak and incomplete Rh agglutinins". Br J Exp Pathol. ...
... and acts as a signal for the synthesis of the surface protein agglutinin. Agglutinin allows the two TSAs to recognize each ...
Hemorheology Agglutinin Wikimedia Commons has media related to Rouleaux. Oxford Textbook of Medicine Stoltz, J.F.; Gaillard, S ...
The cold agglutinin detected is of anti-i specificity. Diagnostic modalities for infectious mononucleosis include: Person's age ... ISBN 978-1-4200-6749-1. Rosenfield RE; Schmidt PJ; Calvo RC; McGinniss MH (1965). "Anti-i, a frequent cold agglutinin in ... Mononucleosis is sometimes accompanied by secondary cold agglutinin disease, an autoimmune disease in which abnormal ...
No name was given to this agglutinin when described. In 1940, Karl Landsteiner and Alexander S. Wiener made the connection to ...
The woman had high levels of antibodies called "cold agglutinins" in her body. Most people have low levels of cold agglutinins ... When levels of cold agglutinins are too high, they cause red blood cells to clump together, and the clumps can block the flow ...
Agglutinins are antibodies that cause the red blood cells to clump together. ... Cold agglutinins: no agglutination in titers at or below 1:16. The examples above are common measurements for results of these ... Warm agglutinins may occur with:. *Infections, including brucellosis, rickettsial disease, salmonella infection, and tularemia ... Agglutinins are antibodies that cause the red blood cells to clump together. ...
... ... Kaarsalo, E. (‎1963)‎. Prevalence of Salmonella agglutinins among the population of a non-epidemic and an epidemic area in ...
... has been granted approval by the EMA for haemolytic anaemia in adult patients with cold agglutinin disease ... Cold agglutinin disease (CAD) is a rare, autoimmune disorder and which is characterised by premature haemolysis (i.e., ... has been granted approval by the EMA for haemolytic anaemia in adult patients with cold agglutinin disease. According to the ... destruction of red blood cells). The termed "cold" refers to the fact that the autoantibodies (termed cold agglutinins) cause ...
Urtica dioica L. agglutinin (UDA) is a low weight lectin with anti-benign prostatic hyperplasia (BPH) impact. ... Urtica dioica L. agglutinin (UDA) is a low weight lectin with anti-benign prostatic hyperplasia (BPH) impact. Here, we examine ... The Agglutinin of Common Nettle (Urtica dioica L.) Plant Effects on Gene Expression Related to Apoptosis of Human Acute Myeloid ...
Cold agglutinin disease. The hemolysis is usually extravascular (removal of C3b-opsonized cells by the reticuloendotelial ... Berentsen S . How I manage cold agglutinin disease. Br J Haematol 2011; 153: 309-317. ... Corticosteroids and splenectomy are not effective to control hemolysis in cold agglutinin disease. Rituximab alone, or in ... cold agglutinin disease, and neuropathy or disease-related hemoglobin level ,10 g/dl or platelet count ,100 × 109/l. On the ...
Evidence Rating Level: 2 (Good) Study Rundown: Cold agglutinin disease is caused by autoantibodies binding to the I antigen on ... and reduce patient fatigue in patients with cold agglutinin disease. 2, Infections and gastrointestinal adverse events were ...
Are you a healthcare provider looking for information on Sutimlimab for Cold Agglutinin Disease? Read about Sutimlimab here. ... Röth A, Barcellini W, DSa S, et al. Sutimlimab in cold agglutinin disease. N Engl J Med. 2021;384(14):1323-1334. doi:10.1056/ ... Cold Agglutinin Disease News. November 20, 2020.. *FDA grants priority review of sutimlimab, potential first approved treatment ... This pathway is overactivated in cold agglutinin disease (CAD). By blocking C1, sutimlimab treats the underlying cause of ...
COLD AGGLUTININ DISEASE. Cold Agglutinin Disease (CAD) is a rare autoimmune blood disease. Where Cold sensitive or cold ... Cold Agglutinin Disease can be considered Primary or Secondary. (Secondary has recently been referred to as CAS or Cold ... While Cold Agglutinin Disease can be passing in nature, or temporary. It can also be long term or a life long disease that ... Cold Agglutinin Disease is a rare type of Autoimmune Hemolytic Anemia. Which is known by a fairly long list of other similar ...
... search for advice and information on Living with Cold agglutinin disease ✓ Thousands of discussions. ... Start new discussions and share with others on your experience with living with Cold agglutinin disease and its impact on your ...
The Soybean agglutinin (SBA) is a major anti-nutritional factor of soybean, it binds to the intestinal epithelial cells in ... Zhao, Y., Qin, G.X., Sun, Z.W., Che, D.S., Bao, N., and Zhang, X.D. (2011). Effects of soybean agglutinin on intestinal barrier ... Pan, L., Qin, G.X., Zhao, Y., Wang, J., Liu, F.F., and Che, D.S. (2013). Effects of soybean agglutinin on mechanical barrier ... Li, Z., Li, D., Qiao, S., Zhu, X., and Huang, C. (2003). Anti-nutritional effects of a moderate dose of soybean agglutinin in ...
The histiocytoses encompass a group of diverse disorders characterized by the accumulation and infiltration of variable numbers of monocytes, macrophages, and dendritic cells in the affected tissues. Such a description excludes diseases in which infiltration of these cells occurs in response to a primary pathology.
Cyanosis due to cold agglutinins. NESER AT, SACKS I. NESER AT, et al. S Afr Med J. 1950 Nov 18;24(46):953-4. S Afr Med J. 1950. ...
Urtica dioica agglutinin. References. *Guzman, J.D. Natural cinnamic acids, synthetic derivatives and hybrids with ... Urtica dioica agglutinin (UDA) and ribavirin, respectively. Compounds of series 3 were inactive towards all tested viruses, ...
The Identity of Precipitin and Agglutinin Creator: Heidelberger, Michael. Kabat, Elvin Abraham, 1914-2000 Date: May 1936 ...
... heat-resistant agglutinin; ibeABC, invasion of brain endothelium; iha, iron-regulated adhesin; ireA, iron-regulated element ( ...
Febrile/cold agglutinins ... Systemic lupus erythematosus Use of certain medicines, including methyldopa, penicillin, and ...
Note: Cold Agglutinin Disease News is strictly a news and information website about the disease. It does not provide medical ... Since I was diagnosed with cold agglutinin disease, I have become familiar with the symptoms, which herald the escalation of my ... The opinions expressed in this column are not those of Cold Agglutinin Disease News or its parent company, BioNews, and are ... A real-life example of how cold exacerbates cold agglutinin disease symptoms ...
Liu Lin Thio, L. T., Clark, G. D., Clifford, D. B., & Zorumski, C. F. (1992). Wheat germ agglutinin enhances EPSCs in cultured ... Liu Lin Thio, LT, Clark, GD, Clifford, DB & Zorumski, CF 1992, Wheat germ agglutinin enhances EPSCs in cultured postnatal rat ... Wheat germ agglutinin enhances EPSCs in cultured postnatal rat hippocampal neurons by blocking ionotropic quisqualate receptor ... Wheat germ agglutinin enhances EPSCs in cultured postnatal rat hippocampal neurons by blocking ionotropic quisqualate receptor ...
wheat germ agglutinin. Dissertation note: Master of Science in Applied Biological Sciences -- Chulabhorn Graduate Institute, ... Quantitative Proteomic Studies of Serum Glycoproteins from Colorectal Cancer Patients Enriched by Wheat Germ Agglutinin By: * ... Quantitative Proteomic Studies of Serum Glycoproteins from Colorectal Cancer Patients Enriched by Wheat Germ Agglutinin ...
Based on composite score (0-100). A score of 0 corresponds to complete disability (or responding extremely limited, difficult or bothersome to all questions answered), while a score of 100 corresponds to no disability (or responding not at all limited, difficult or bothersome to all questions answered).. AFEQT Evaluates Health Related Quality of Life (HRQoL) across three domains Symptoms - Four questions specifically targeted to assess AF related symptoms Daily Activities - Eight questions that evaluate daily function in AF patients Treatment Concerns - Six questions that assess AF treatment concerns in patients The overall composite score and domains will be summarized by presenting the means, medians, standard deviations, interquartile ranges, minimum, and maximum ...
PLANT AGGLUTININS , A very good community tank population , This is the BEST Filtration for Aquariums for Simplicity, Price and ...
Categories: Agglutinins Image Types: Photo, Illustrations, Video, Color, Black&White, PublicDomain, CopyrightRestricted 65 ...
These are cold agglutinins. So the official name for this form of pneumonia is cold agglutinin positive primary atypical ... RC: And this has to do with a condition called cold-agglutinin positive primary atypical pneumonia. Its a pneumonia thats not ...
It is based on presence of agglutinins and not hemolysins. Agglutinins are believed present with hemolysins in all but Q system ...
9. Peanut agglutinin. A useful marker for histiocytosis X and interdigitating reticulum cells.. Ree HJ; Kadin ME. Cancer; 1986 ... A comparative study of peanut agglutinin, Leu-M1, LN-2, and Ber-H2.. Ree HJ; Neiman RS; Martin AW; Dallenbach F; Stein H. ... A comparison with Leu-M1 (CD15), LN2 (CD74), peanut agglutinin, and Ber-H2 (CD30).. Sarker AB; Akagi T; Jeon HJ; Miyake K; ...
... lectin wheat germ agglutinin (red) visualizes the GFB; DNA (Draq5) shown in blue. Care was taken to use N- and P-cadherin ...
  • The effect of the lectin wheat germ agglutinin (WGA), an inhibitor of ionotropic quisqualate receptor desensitization, on both evoked and spontaneous fast excitatory postsynaptic events was examined in cultured postnatal rat hippocampal neurons with the use of whole cell recordings. (
  • Immobilized Wheat Germ Agglutinin (WGA) is prepared by covalently linking WGA to the 6% cross-linked agarose. (
  • A glycoform of MUC5AC bound to the plant lectin wheat germ agglutinin (WGA). (
  • The woman had high levels of antibodies called "cold agglutinins" in her body. (
  • Agglutinins are antibodies that cause the red blood cells to clump together. (
  • A comparison with Leu-M1 (CD15), LN2 (CD74), peanut agglutinin, and Ber-H2 (CD30). (
  • 9. Peanut agglutinin. (
  • FSIP2 co-localised with peanut agglutinin in the acrosome during spermatogenesis. (
  • Urtica dioica L. agglutinin (UDA) is a low weight lectin with anti-benign prostatic hyperplasia (BPH) impact. (
  • Febrile (warm) agglutinins are active at normal body temperatures. (
  • According to the manufacturer, Sanofi, sutimlimab (Enjaymo) has been approved for the management of adult patients who have haemolytic anaemia with cold agglutinin disease. (
  • Enjaymo™ (sutimlimab), formerly known as BIVV009 or TNT009, was approved by the US Food and Drug Administration in February 2022 as the first treatment designated for cold agglutinin disease (CAD). (
  • Cold agglutinins are active at cold temperatures. (
  • The termed "cold" refers to the fact that the autoantibodies (termed 'cold agglutinins') cause haemolysis at cold temperatures, usually 3 to 4 o C. Haemolytic anaemias are due to the production of autoantibodies (IgM) directed against surface antigens on red blood cells. (
  • When levels of cold agglutinins are too high, they cause red blood cells to clump together, and the clumps can block the flow of blood to the fingers, nose, ears and toes, consequently causing symptoms similar to frostbite. (
  • Since I was diagnosed with cold agglutinin disease , I have become familiar with the symptoms , which herald the escalation of my blood condition. (
  • Start new discussions and share with others on your experience with living with Cold agglutinin disease and its impact on your personal, family, and professional life. (
  • An abnormal (positive) result means there were agglutinins in your blood sample. (
  • Cold agglutinin disease (CAD) is a rare, autoimmune disorder and which is characterised by premature haemolysis (i.e., destruction of red blood cells). (
  • In an in vitro study, TNT003, a murine monoclonal antibody that targets C1s, demonstrated the ability to inhibit complement-mediated phagocytosis and red blood cell (RBC) lysis in serum derived from a healthy individual as a source of complement and serum from a patient as a source of cold agglutinin. (
  • Cold Agglutinin Disease (CAD) is a rare autoimmune blood disease. (
  • Most people have low levels of cold agglutinins, which help the body respond to infection. (