AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesInformation ScienceNamed GroupsHealth Care
Corpus CallosumAgenesis of Corpus CallosumAcrocallosal SyndromeCorpus LuteumAnisotropyNerve Fibers, MyelinatedDiffusion Tensor ImagingMagnetic Resonance ImagingCuprizoneDiffusion Magnetic Resonance ImagingAnodontiaAbnormalities, MultipleNervous System MalformationsBrainInternal CapsuleDiffuse Axonal InjuryImage Processing, Computer-AssistedFunctional LateralitySeptum PellucidumFornix, BrainPAX9 Transcription FactorDemyelinating DiseasesBrain DiseasesNeural PathwaysMyelin SheathAicardi SyndromeTooth AbnormalitiesHydrocephalusCerebral CortexOligodendrogliaMalformations of Cortical DevelopmentBrain MappingSyndromeAtrophyCongenital AbnormalitiesIntellectual DisabilityLeukoencephalopathiesAxonsCerebral VentriclesHypertelorismPregnancyUrogenital AbnormalitiesMicrocephalyBrain InjuriesDominance, CerebralCorpora AllataDandy-Walker SyndromeMarchiafava-Bignami DiseaseUltrasonography, PrenatalPrenatal DiagnosisMeningomyeloceleLissencephalyOrgan SizeNeuroimagingInfant, NewbornFetal DiseasesCerebrumSpastic Paraplegia, HereditaryCraniofacial AbnormalitiesTooth ExfoliationMSX1 Transcription FactorCebusLipomaImage Interpretation, Computer-AssistedGestational AgeNeuronal Migration DisordersHyperglycinemia, NonketoticNeurogliaNeuropsychological TestsPenisWhale, KillerImaging, Three-DimensionalAgingLateral VentriclesDichotic Listening TestsCorpus Luteum MaintenanceReference ValuesAnalysis of VarianceEchoencephalographySex CharacteristicsSurgically-Created StructuresApraxiasLuteolysis
Corpus Callosum
Broad plate of dense myelinated fibers that reciprocally interconnect regions of the cortex in all lobes with corresponding regions of the opposite hemisphere. The corpus callosum is located deep in the longitudinal fissure.
Agenesis of Corpus Callosum
Birth defect that results in a partial or complete absence of the CORPUS CALLOSUM. It may be isolated or a part of a syndrome (e.g., AICARDI'S SYNDROME; ACROCALLOSAL SYNDROME; ANDERMANN SYNDROME; and HOLOPROSENCEPHALY). Clinical manifestations include neuromotor skill impairment and INTELLECTUAL DISABILITY of variable severity.
Acrocallosal Syndrome
Autosomal recessive syndrome characterized by hypogenesis or agenesis of CORPUS CALLOSUM. Clinical features include MENTAL RETARDATION; CRANIOFACIAL ABNORMALITIES; digital malformations, and growth retardation.
Corpus Luteum
The yellow body derived from the ruptured OVARIAN FOLLICLE after OVULATION. The process of corpus luteum formation, LUTEINIZATION, is regulated by LUTEINIZING HORMONE.
Anisotropy
A physical property showing different values in relation to the direction in or along which the measurement is made. The physical property may be with regard to thermal or electric conductivity or light refraction. In crystallography, it describes crystals whose index of refraction varies with the direction of the incident light. It is also called acolotropy and colotropy. The opposite of anisotropy is isotropy wherein the same values characterize the object when measured along axes in all directions.
Nerve Fibers, Myelinated
A class of nerve fibers as defined by their structure, specifically the nerve sheath arrangement. The AXONS of the myelinated nerve fibers are completely encased in a MYELIN SHEATH. They are fibers of relatively large and varied diameters. Their NEURAL CONDUCTION rates are faster than those of the unmyelinated nerve fibers (NERVE FIBERS, UNMYELINATED). Myelinated nerve fibers are present in somatic and autonomic nerves.
Diffusion Tensor Imaging
The use of diffusion ANISOTROPY data from diffusion magnetic resonance imaging results to construct images based on the direction of the faster diffusing molecules.
Magnetic Resonance Imaging
Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.
Cuprizone
Copper chelator that inhibits monoamine oxidase and causes liver and brain damage.
Diffusion Magnetic Resonance Imaging
A diagnostic technique that incorporates the measurement of molecular diffusion (such as water or metabolites) for tissue assessment by MRI. The degree of molecular movement can be measured by changes of apparent diffusion coefficient (ADC) with time, as reflected by tissue microstructure. Diffusion MRI has been used to study BRAIN ISCHEMIA and tumor response to treatment.
Anodontia
Congenital absence of the teeth; it may involve all (total anodontia) or only some of the teeth (partial anodontia, hypodontia), and both the deciduous and the permanent dentition, or only teeth of the permanent dentition. (Dorland, 27th ed)
Abnormalities, Multiple
Nervous System Malformations
Structural abnormalities of the central or peripheral nervous system resulting primarily from defects of embryogenesis.
Brain
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
Internal Capsule
WHITE MATTER pathway, flanked by nuclear masses, consisting of both afferent and efferent fibers projecting between the WHITE MATTER and the BRAINSTEM. It consists of three distinct parts: an anterior limb, posterior limb, and genu.
Diffuse Axonal Injury
A relatively common sequela of blunt head injury, characterized by a global disruption of axons throughout the brain. Associated clinical features may include NEUROBEHAVIORAL MANIFESTATIONS; PERSISTENT VEGETATIVE STATE; DEMENTIA; and other disorders.
Image Processing, Computer-Assisted
A technique of inputting two-dimensional images into a computer and then enhancing or analyzing the imagery into a form that is more useful to the human observer.
Functional Laterality
Behavioral manifestations of cerebral dominance in which there is preferential use and superior functioning of either the left or the right side, as in the preferred use of the right hand or right foot.
Septum Pellucidum
A triangular double membrane separating the anterior horns of the LATERAL VENTRICLES of the brain. It is situated in the median plane and bounded by the CORPUS CALLOSUM and the body and columns of the FORNIX (BRAIN).
Fornix, Brain
Heavily myelinated fiber bundle of the TELENCEPHALON projecting from the hippocampal formation to the HYPOTHALAMUS. Some authorities consider the fornix part of the LIMBIC SYSTEM. The fimbria starts as a flattened band of axons arising from the subiculum and HIPPOCAMPUS, which then thickens to form the fornix.
PAX9 Transcription Factor
A paired box transcription factor that is involved in ODONTOGENESIS.
Demyelinating Diseases
Diseases characterized by loss or dysfunction of myelin in the central or peripheral nervous system.
Brain Diseases
Pathologic conditions affecting the BRAIN, which is composed of the intracranial components of the CENTRAL NERVOUS SYSTEM. This includes (but is not limited to) the CEREBRAL CORTEX; intracranial white matter; BASAL GANGLIA; THALAMUS; HYPOTHALAMUS; BRAIN STEM; and CEREBELLUM.
Neural Pathways
Neural tracts connecting one part of the nervous system with another.
Myelin Sheath
The lipid-rich sheath surrounding AXONS in both the CENTRAL NERVOUS SYSTEMS and PERIPHERAL NERVOUS SYSTEM. The myelin sheath is an electrical insulator and allows faster and more energetically efficient conduction of impulses. The sheath is formed by the cell membranes of glial cells (SCHWANN CELLS in the peripheral and OLIGODENDROGLIA in the central nervous system). Deterioration of the sheath in DEMYELINATING DISEASES is a serious clinical problem.
Aicardi Syndrome
A rare genetic disorder characterized by partial or complete absence of the CORPUS CALLOSUM, resulting in infantile spasms, MENTAL RETARDATION, and lesions of the RETINA or OPTIC NERVE.
Tooth Abnormalities
Congenital absence of or defects in structures of the teeth.
Hydrocephalus
Excessive accumulation of cerebrospinal fluid within the cranium which may be associated with dilation of cerebral ventricles, INTRACRANIAL HYPERTENSION; HEADACHE; lethargy; URINARY INCONTINENCE; and ATAXIA.
Cerebral Cortex
The thin layer of GRAY MATTER on the surface of the CEREBRAL HEMISPHERES that develops from the TELENCEPHALON and folds into gyri and sulchi. It reaches its highest development in humans and is responsible for intellectual faculties and higher mental functions.
Oligodendroglia
A class of large neuroglial (macroglial) cells in the central nervous system. Oligodendroglia may be called interfascicular, perivascular, or perineuronal (not the same as SATELLITE CELLS, PERINEURONAL of GANGLIA) according to their location. They form the insulating MYELIN SHEATH of axons in the central nervous system.
Malformations of Cortical Development
Abnormalities in the development of the CEREBRAL CORTEX. These include malformations arising from abnormal neuronal and glial CELL PROLIFERATION or APOPTOSIS (Group I); abnormal neuronal migration (Group II); and abnormal establishment of cortical organization (Group III). Many INBORN METABOLIC BRAIN DISORDERS affecting CNS formation are often associated with cortical malformations. They are common causes of EPILEPSY and developmental delay.
Brain Mapping
Imaging techniques used to colocalize sites of brain functions or physiological activity with brain structures.
Syndrome
A characteristic symptom complex.
Atrophy
Decrease in the size of a cell, tissue, organ, or multiple organs, associated with a variety of pathological conditions such as abnormal cellular changes, ischemia, malnutrition, or hormonal changes.
Congenital Abnormalities
Malformations of organs or body parts during development in utero.
Intellectual Disability
Subnormal intellectual functioning which originates during the developmental period. This has multiple potential etiologies, including genetic defects and perinatal insults. Intelligence quotient (IQ) scores are commonly used to determine whether an individual has an intellectual disability. IQ scores between 70 and 79 are in the borderline range. Scores below 67 are in the disabled range. (from Joynt, Clinical Neurology, 1992, Ch55, p28)
Leukoencephalopathies
Any of various diseases affecting the white matter of the central nervous system.
Axons
Nerve fibers that are capable of rapidly conducting impulses away from the neuron cell body.
Cerebral Ventricles
Four CSF-filled (see CEREBROSPINAL FLUID) cavities within the cerebral hemispheres (LATERAL VENTRICLES), in the midline (THIRD VENTRICLE) and within the PONS and MEDULLA OBLONGATA (FOURTH VENTRICLE).
Hypertelorism
Abnormal increase in the interorbital distance due to overdevelopment of the lesser wings of the sphenoid.
Pregnancy
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
Urogenital Abnormalities
Congenital structural abnormalities of the UROGENITAL SYSTEM in either the male or the female.
Microcephaly
A congenital abnormality in which the CEREBRUM is underdeveloped, the fontanels close prematurely, and, as a result, the head is small. (Desk Reference for Neuroscience, 2nd ed.)
Brain Injuries
Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.
Dominance, Cerebral
Dominance of one cerebral hemisphere over the other in cerebral functions.
Corpora Allata
Paired or fused ganglion-like bodies in the head of insects. The bodies secrete hormones important in the regulation of metamorphosis and the development of some adult tissues.
Dandy-Walker Syndrome
A congenital abnormality of the central nervous system marked by failure of the midline structures of the cerebellum to develop, dilation of the fourth ventricle, and upward displacement of the transverse sinuses, tentorium, and torcula. Clinical features include occipital bossing, progressive head enlargement, bulging of anterior fontanelle, papilledema, ataxia, gait disturbances, nystagmus, and intellectual compromise. (From Menkes, Textbook of Child Neurology, 5th ed, pp294-5)
Marchiafava-Bignami Disease
A neurodegenerative condition that is characterized by demyelination or necrosis of the CORPUS CALLOSUM. Symptoms include DEPRESSION; PARANOIA; DEMENTIA; SEIZURES; and ATAXIA which can progress to COMA and death in a few months. Marchiafava-Bignami syndrome is seen often in alcoholics but has been found in non-alcoholics as well.
Ultrasonography, Prenatal
The visualization of tissues during pregnancy through recording of the echoes of ultrasonic waves directed into the body. The procedure may be applied with reference to the mother or the fetus and with reference to organs or the detection of maternal or fetal disease.
Prenatal Diagnosis
Determination of the nature of a pathological condition or disease in the postimplantation EMBRYO; FETUS; or pregnant female before birth.
Meningomyelocele
Congenital, or rarely acquired, herniation of meningeal and spinal cord tissue through a bony defect in the vertebral column. The majority of these defects occur in the lumbosacral region. Clinical features include PARAPLEGIA, loss of sensation in the lower body, and incontinence. This condition may be associated with the ARNOLD-CHIARI MALFORMATION and HYDROCEPHALUS. (From Joynt, Clinical Neurology, 1992, Ch55, pp35-6)
Lissencephaly
A "smooth brain" malformation of the CEREBRAL CORTEX resulting from abnormal location of developing neurons during corticogenesis. It is characterized by an absence of normal convoluted indentations on the surface of the brain (agyria), or fewer and shallower indentations (pachygryia). There is a reduced number of cortical layers, typically 4 instead of 6, resulting in a thickened cortex, and reduced cerebral white matter that is a reversal of the normal ratio of cerebral white matter to cortex.
Organ Size
The measurement of an organ in volume, mass, or heaviness.
Neuroimaging
Non-invasive methods of visualizing the CENTRAL NERVOUS SYSTEM, especially the brain, by various imaging modalities.
Infant, Newborn
An infant during the first month after birth.
Fetal Diseases
Pathophysiological conditions of the FETUS in the UTERUS. Some fetal diseases may be treated with FETAL THERAPIES.
Cerebrum
Derived from TELENCEPHALON, cerebrum is composed of a right and a left hemisphere. Each contains an outer cerebral cortex and a subcortical basal ganglia. The cerebrum includes all parts within the skull except the MEDULLA OBLONGATA, the PONS, and the CEREBELLUM. Cerebral functions include sensorimotor, emotional, and intellectual activities.
Spastic Paraplegia, Hereditary
A group of inherited diseases that share similar phenotypes but are genetically diverse. Different genetic loci for autosomal recessive, autosomal dominant, and x-linked forms of hereditary spastic paraplegia have been identified. Clinically, patients present with slowly progressive distal limb weakness and lower extremity spasticity. Peripheral sensory neurons may be affected in the later stages of the disease. (J Neurol Neurosurg Psychiatry 1998 Jan;64(1):61-6; Curr Opin Neurol 1997 Aug;10(4):313-8)
Craniofacial Abnormalities
Congenital structural deformities, malformations, or other abnormalities of the cranium and facial bones.
Tooth Exfoliation
Physiologic loss of the primary dentition. (Zwemer, Boucher's Clinical Dental Terminology, 4th ed)
MSX1 Transcription Factor
A homeodomain protein that interacts with TATA-BOX BINDING PROTEIN. It represses GENETIC TRANSCRIPTION of target GENES and plays a critical role in ODONTOGENESIS.
Cebus
A genus of the family CEBIDAE, subfamily CEBINAE, consisting of four species which are divided into two groups, the tufted and untufted. C. apella has tufts of hair over the eyes and sides of the head. The remaining species are without tufts - C. capucinus, C. nigrivultatus, and C. albifrons. Cebus inhabits the forests of Central and South America.
Lipoma
A benign tumor composed of fat cells (ADIPOCYTES). It can be surrounded by a thin layer of connective tissue (encapsulated), or diffuse without the capsule.
Image Interpretation, Computer-Assisted
Methods developed to aid in the interpretation of ultrasound, radiographic images, etc., for diagnosis of disease.
Gestational Age
The age of the conceptus, beginning from the time of FERTILIZATION. In clinical obstetrics, the gestational age is often estimated as the time from the last day of the last MENSTRUATION which is about 2 weeks before OVULATION and fertilization.
Neuronal Migration Disorders
Disorders resulting from defects in migration of neuronal cells during neurogenesis. Developing nerve cells either fail to migrate or they migrate to incorrect positions resulting in formation of heterotopias, lissencephaly, or other malformations and dysfunctions of the nervous system.
Hyperglycinemia, Nonketotic
An autosomal recessive metabolic disorder caused by deficiencies in the mitochondrial GLYCINE cleavage system.
Neuroglia
The non-neuronal cells of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu, participate in the BLOOD-BRAIN BARRIER and BLOOD-RETINAL BARRIER, form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons. Neuroglia have high-affinity transmitter uptake systems, voltage-dependent and transmitter-gated ion channels, and can release transmitters, but their role in signaling (as in many other functions) is unclear.
Neuropsychological Tests
Tests designed to assess neurological function associated with certain behaviors. They are used in diagnosing brain dysfunction or damage and central nervous system disorders or injury.
Penis
The external reproductive organ of males. It is composed of a mass of erectile tissue enclosed in three cylindrical fibrous compartments. Two of the three compartments, the corpus cavernosa, are placed side-by-side along the upper part of the organ. The third compartment below, the corpus spongiosum, houses the urethra.
Whale, Killer
The species Orcinus orca, in the family Delphinidae, characterized by its black and white coloration, and huge triangular dorsal fin. It is the largest member of the DOLPHINS and derives its name from the fact that it is a fearsome predator.
Imaging, Three-Dimensional
The process of generating three-dimensional images by electronic, photographic, or other methods. For example, three-dimensional images can be generated by assembling multiple tomographic images with the aid of a computer, while photographic 3-D images (HOLOGRAPHY) can be made by exposing film to the interference pattern created when two laser light sources shine on an object.
Aging
The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
Lateral Ventricles
Cavity in each of the CEREBRAL HEMISPHERES derived from the cavity of the embryonic NEURAL TUBE. They are separated from each other by the SEPTUM PELLUCIDUM, and each communicates with the THIRD VENTRICLE by the foramen of Monro, through which also the choroid plexuses (CHOROID PLEXUS) of the lateral ventricles become continuous with that of the third ventricle.
Dichotic Listening Tests
Tests for central hearing disorders based on the competing message technique (binaural separation).
Corpus Luteum Maintenance
Process of maintaining the functions of CORPORA LUTEA, specifically PROGESTERONE production which is regulated primarily by pituitary LUTEINIZING HORMONE in cycling females, and by PLACENTAL HORMONES in pregnant females. The ability to maintain luteal functions is important in PREGNANCY MAINTENANCE.
Reference Values
The range or frequency distribution of a measurement in a population (of organisms, organs or things) that has not been selected for the presence of disease or abnormality.
Analysis of Variance
A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.
Echoencephalography
Use of reflected ultrasound in the diagnosis of intracranial pathologic processes.
Sex Characteristics
Those characteristics that distinguish one SEX from the other. The primary sex characteristics are the OVARIES and TESTES and their related hormones. Secondary sex characteristics are those which are masculine or feminine but not directly related to reproduction.
Surgically-Created Structures
Organs or parts of organs surgically formed from nearby tissue to function as substitutes for diseased or surgically removed tissue.
Apraxias
A group of cognitive disorders characterized by the inability to perform previously learned skills that cannot be attributed to deficits of motor or sensory function. The two major subtypes of this condition are ideomotor (see APRAXIA, IDEOMOTOR) and ideational apraxia, which refers to loss of the ability to mentally formulate the processes involved with performing an action. For example, dressing apraxia may result from an inability to mentally formulate the act of placing clothes on the body. Apraxias are generally associated with lesions of the dominant PARIETAL LOBE and supramarginal gyrus. (From Adams et al., Principles of Neurology, 6th ed, pp56-7)
Luteolysis
Degradation of CORPUS LUTEUM. In the absence of pregnancy and diminishing trophic hormones, the corpus luteum undergoes luteolysis which is characterized by the involution and cessation of its endocrine function.

Callosal and cortical contribution to procedural learning. (1/203)

Acallosal and callosotomized subjects usually show impairments on tasks requiring bilateral interdependent motor control. However, few studies have assessed the ability of these subjects to learn a skill that requires the simultaneous contribution of each hemisphere in its acquisition. The present study examined whether acallosal and callosotomized subjects could learn a visuomotor skill that involved a motor control from either both or a single hemisphere. Eleven adult patients, six acallosal and five callosotomized, participated in this study. Seven of these patients had epileptic foci located in the frontal and/or temporal areas and one of the acallosal patients showed bilateral prefrontal atrophy following surgical removal of an orbitofrontal cyst. The performance of the experimental subjects was compared with that of 11 matched control subjects, on a modified version of a serial reaction time task developed by Nissen and Bullemer (Cogn Psychol 1987; 19: 1-32). This skill acquisition task involved bimanual or unimanual key-pressing responses to a sequence of 10 visual stimuli that was repeated 160 times. A declarative memory task was then performed to assess explicit knowledge of the sequence. None of the experimental subjects learned the task in the bimanual condition. Patients with frontal epileptic foci or orbitofrontal damage also failed to learn the task in the unimanual condition when they were using the hand contralateral to the damaged hemisphere. All other subjects, including the acallosal and callosotomized patients with temporal foci, learned the visuomotor skill as well as their controls in the unimanual condition. In spite of the absence of transfer and interhemispheric integration of procedural learning, some of the acallosal and callosotomized patients were able to learn the sequence explicitly. These findings indicate that the corpus callosum and the frontal cortical areas are important for procedural learning of a visuomotor skill. They also confirm the dissociation described by Squire (Science 1986; 232: 1612-9 and J Cogn Neurosci 1992; 4: 232-43) between the declarative and procedural memory systems and extend this dissociation to processes involving simultaneous bihemispheric co-operation.  (+info)

Abnormalities in neuronal process extension, hippocampal development, and the ventricular system of L1 knockout mice. (2/203)

In humans, mutations in the L1 cell adhesion molecule are associated with a neurological syndrome termed CRASH, which includes corpus callosum agenesis, mental retardation, adducted thumbs, spasticity, and hydrocephalus. A mouse model with a null mutation in the L1 gene (Cohen et al., 1997) was analyzed for brain abnormalities by Nissl and Golgi staining and immunocytochemistry. In the motor, somatosensory, and visual cortex, many pyramidal neurons in layer V exhibited undulating apical dendrites that did not reach layer I. The hippocampus of L1 mutant mice was smaller than normal, with fewer pyramidal and granule cells. The corpus callosum of L1-minus mice was reduced in size because of the failure of many callosal axons to cross the midline. Enlarged ventricles and septal abnormalities were also features of the mutant mouse brain. Immunoperoxidase staining showed that L1 was abundant in developing neurons at embryonic day 18 (E18) in wild-type cerebral cortex, hippocampus, and corpus callosum and then declined to low levels with maturation. In the E18 cortex, L1 colocalized with microtubule-associated protein 2, a marker of dendrites and somata. These new findings suggest new roles for L1 in the mechanism of cortical dendrite differentiation, as well as in guidance of callosal axons and regulation of hippocampal development. The phenotype of the L1 mutant mouse indicates that it is a potentially valuable model for the human CRASH syndrome.  (+info)

Reduction cranioplasty for macrocephaly. Two case reports. (3/203)

Multi-stage reduction cranioplasty was performed on two children with severe macrocephaly secondary to hydrocephalus. One patient underwent a four-stage operation, and the other underwent a two-stage operation. The postoperative course of both patients was uneventful. Reduction cranioplasty improved quality of life for both patients, and good cosmetic results were achieved. Reduction cranioplasty is effective for the treatment of macrocephaly, and multi-stage surgery can reduce the associated risks.  (+info)

Dissociation of the pathways mediating ipsilateral and contralateral motor-evoked potentials in human hand and arm muscles. (4/203)

1. Growing evidence points toward involvement of the human motor cortex in the control of the ipsilateral hand. We used focal transcranial magnetic stimulation (TMS) to examine the pathways of these ipsilateral motor effects. 2. Ipsilateral motor-evoked potentials (MEPs) were obtained in hand and arm muscles of all 10 healthy adult subjects tested. They occurred in the finger and wrist extensors and the biceps, but no response or inhibitory responses were observed in the opponens pollicis, finger and wrist flexors and the triceps. 3. The production of ipsilateral MEPs required contraction of the target muscle. The threshold TMS intensity for ipsilateral MEPs was on average 1.8 times higher, and the onset was 5.7 ms later (in the wrist extensor muscles) compared with size-matched contralateral MEPs. 4. The corticofugal pathways of ipsilateral and contralateral MEPs could be dissociated through differences in cortical map location and preferred stimulating current direction. 5. Both ipsi- and contralateral MEPs in the wrist extensors increased with lateral head rotation toward, and decreased with head rotation away from, the side of the TMS, suggesting a privileged input of the asymmetrical tonic neck reflex to the pathway of the ipsilateral MEP. 6. Large ipsilateral MEPs were obtained in a patient with complete agenesis of the corpus callosum. 7. The dissociation of the pathways for ipsilateral and contralateral MEPs indicates that corticofugal motor fibres other than the fast-conducting crossed corticomotoneuronal system can be activated by TMS. Our data suggest an ipsilateral oligosynaptic pathway, such as a corticoreticulospinal or a corticopropriospinal projection as the route for the ipsilateral MEP. Other pathways, such as branching of corticomotoneuronal axons, a transcallosal projection or a slow-conducting monosynaptic ipsilateral pathway are very unlikely or can be excluded.  (+info)

The homeodomain protein vax1 is required for axon guidance and major tract formation in the developing forebrain. (5/203)

The homeodomain protein Vax1 is expressed in a highly circumscribed set of cells at the ventral anterior midline of the embryonic CNS. These cells populate the choroid fissure of the optic disk, the body of the optic stalk and nerve, the optic chiasm and ventral diencephalon, and the anterior midline zones that abut developing commissural tracts. We have generated mutant mice that lack Vax1. In these mice (1) the optic disks fail to close, leading to coloboma and loss of the eye-nerve boundary; (2) optic nerve glia fail to associate with and appear to repulse ingrowing retinal axons, resulting in a fascicle of axons that are completely segregated from optic nerve astrocytes; (3) retinal axons fail to penetrate the brain in significant numbers and fail to form an optic chiasm; and (4) axons in multiple commissural tracts of the anterior CNS, including the corpus callosum and the hippocampal and anterior commissures, fail to cross the midline. These axon guidance defects do not result from the death of normally Vax1(+) midline cells but, instead, correlate with markedly diminished expression of attractive guidance cues in these cells. Vax1 therefore regulates the guidance properties of a set of anterior midline cells that orchestrate axon trajectories in the developing mammalian forebrain.  (+info)

Neuropathological abnormalities of the corpus callosum in schizophrenia: a diffusion tensor imaging study. (6/203)

OBJECTIVES: Diffusion tensor imaging (DTI), a technique capable of examining water diffusion in different tissues and the organisation of white matter tracts, was used to investigate the neuropathology of the corpus callosum in vivo in patients with schizophrenia. METHODS: Diffusion tensor imaging was performed in 20 schizophrenic patients and 25 healthy controls. Two complementary measures, mean diffusivity and fractional anisotropy, which are considered to be sensitive indices of axonal integrity, were obtained from regions of interest in the genu (anterior) and splenium (posterior) of the corpus callosum. RESULTS: Mean diffusivity was significantly increased and fractional anisotropy significantly reduced in the splenium but not the genu of the corpus callosum in the schizophrenic group compared with controls. There were no significant sex differences in the DTI measures for either the schizophrenic or control group. Clinical variables such as age, duration of illness, dose of antipsychotic medication, and schizophrenic symptoms did not predict the DTI changes in the schizophrenic patients. CONCLUSIONS: The presence of DTI changes in the splenium but not the genu of the corpus callosum suggests that there may be a focal disruption of commisural connectivity in schizophrenia. However, these findings do not exclude the possibility of abnormalities in other areas of the corpus callosum or other regions of white matter and further research using different methods of analysis may enable us to clarify this. Diffusion tensor imaging is a valuable tool in investigating the structure of white matter in schizophrenia.  (+info)

Parallel visuomotor processing in the split brain: cortico-subcortical interactions. (7/203)

We tested nine patients with callosal pathology in a simple reaction time task with and without redundant targets in the same or opposite visual hemifield. Four patients showed large facilitation (redundancy gain) in the presence of a redundant target, exceeding probability summation models (neural summation). Five patients showed redundancy gain not exceeding probability models. Violation of probability models was not associated with a specific type of callosal lesion. Neural summation, which probably occurs at collicular level, may be modulated by cortical activity. To test this hypothesis, we used functional MRI. During detection of redundant simultaneous targets, activations in the extrastriate cortex were observed in a patient with callosal agenesis and redundancy gain violating probability models, but not in a patient with callosal agenesis and redundancy gain not exceeding probability models. We conclude that cortical activity in the extrastriate cortex may be a modulating factor in the magnitude of the redundancy gain during parallel visuomotor transforms.  (+info)

Agenesis of corpus callosum - a rare case. (8/203)

A case of corpus callosum agenesis associated with a chromosomal structural defect is described.  (+info)

Sex differences associated with corpus callosum development in human infants: A longitudinal multimodal imaging study<...
TY - JOUR. T1 - Sex differences associated with corpus callosum development in human infants. T2 - A longitudinal multimodal imaging study. AU - IBIS Network. AU - Schmied, Astrid. AU - Soda, Takahiro. AU - Gerig, Guido. AU - Styner, Martin. AU - Swanson, Meghan R.. AU - Elison, Jed T.. AU - Shen, Mark D.. AU - McKinstry, Robert C.. AU - Pruett, John R.. AU - Botteron, Kelly N.. AU - Estes, Annette M.. AU - Dager, Stephen R.. AU - Hazlett, Heather C.. AU - Schultz, Robert T.. AU - Piven, Joseph. AU - Wolff, Jason J.. PY - 2020/7/15. Y1 - 2020/7/15. N2 - The corpus callosum (CC) is the largest connective pathway in the human brain, linking cerebral hemispheres. There is longstanding debate in the scientific literature whether sex differences are evident in this structure, with many studies indicating the structure is larger in females. However, there are few data pertaining to this issue in infancy, during which time the most rapid developmental changes to the CC occur. In this study, we examined ...
https://nyuscholars.nyu.edu/en/publications/sex-differences-associated-with-corpus-callosum-development-in-hu
Partial Agenesis of the Corpus Callosum with Interhemispheric Lipoma: Case Report :: Science Publishing GroupPartial Agenesis of the Corpus Callosum with Interhemispheric Lipoma: Case Report :: Science Publishing Group
The agenesis of the corpus callosum and lipoma is a very rare association. We report the case of an 18-years old young patient with no history who was admitted to the emergency department for generalized seizures and atypical headache, the onset of symptoms dated back to two months, neurological examination was normal. The brain computed tomography scan and the magnetic resonance showed the lipoma and the partial agenesis of the corpus callosum.
http://www.ijmedicalimaging.org/article/156/10.11648.j.ijmi.20140204.12
Plus itPlus it
The corpus callosum is the major interhemispheric commissure in the human brain, comprising ∼3 million myelinated fibers that connect homologous regions in the neocortex. To date, ,50 different human congenital syndromes have been described (for review, see Richards et al., 2004) in which dysgenesis or partial agenesis of the corpus callosum occurs. In these syndromes, callosal axons approach but are unable to cross the midline at the corticoseptal boundary and instead form disorganized bundles of axons (Probst bundles) on the ipsilateral side. Failure of callosal midline crossing and Probst bundle formation have also been seen in mice lacking a variety of axon guidance receptors, including the netrin receptor DCC (deleted in colorectal cancer), the repulsive guidance receptors EphB2 and EphB3, and the semaphorin receptor neuropilin-1 (for review, see Richards et al., 2004). Thus, a variety of molecular navigational systems govern the axon pathfinding of callosal axons as they approach and ...
https://www.jneurosci.org/content/26/21/5840
Agenesis of the corpus callosum | Radiology Case | Radiopaedia.orgAgenesis of the corpus callosum | Radiology Case | Radiopaedia.org
The corpus callosum is absent.. Axial images: The bodies of lateral venticles have a parallel orientation. Fibers of white matter located in the medial side of bodies of lateral ventricles are called Probst bundle. These are considered as the fibers that meant to make corpus callosum. The posterior parts of lateral ventricles are enlarged; this is called colpocephaly. Coronal images: Steer horn, and Viking helmet signs are made by the frontal horns of the lateral ventricles in the coronal plane.. Sagittal image: Brain sulci have a sun ray appearance in the midsagittal plane. ...
https://radiopaedia.org/cases/agenesis-of-the-corpus-callosum-3
Longitudinal callosal fascicle - WikipediaLongitudinal callosal fascicle - Wikipedia
Longitudinal callosal fascicles (or Probst bundles) are abnormal collections of brain cells characteristic of patients with agenesis of the corpus callosum. Failure of the callosally-projecting neurons (mostly layer 2/3 pyramidal neurons) to extend axons across the midline and therefore form the corpus callosum[clarification needed] results in anomalous collection of these axonal projections in both hemispheres. Longitudinal callosal fascicles were originally described by Moriz Probst in 1901 by gross anatomical observation. More recently, these anomalies are detected by Magnetic Resonance Imaging or Diffusion Tensor Imaging. Probst, M. (1901), Über den Bau des vollständig balkenlosen Großhirns, Arch Psychiatr, 34: 709-786, doi:10.1007/bf02680175 Barkovich, AJ.; Norman, D. (Jul 1988), Anomalies of the corpus callosum: correlation with further anomalies of the brain., AJR Am J Roentgenol, 151 (1): 171-9, PMID 3259802 Lee, SK.; Mori, S.; Kim, DJ.; Kim, SY.; Kim, SY.; Kim, DI. (Jan 2004). ...
https://en.wikipedia.org/wiki/Longitudinal_callosal_fascicle
Friends Just Understand … Thought and Poem … by Jeanne Claire Probst - Bethel AdvocateFriends Just Understand … Thought and Poem … by Jeanne Claire Probst - Bethel Advocate
The Fifteen Houses, a Novel. The Fifteen Houses is the first book of this new and exciting series to be published. Staged in the beautiful and scenic palate of East Longmeadow, Massachusetts, in the early 1950s, the main character delves into her reoccurring and discomforting memories of her younger, formative years. Searching for answers to questions that have resurfaced in her mind over and over again during her time away from her family, she seeks to find rhyme and reasons to her insecurities, anger, phobias, fears, and lifes choices. Julianne Marguerite, one of eleven children, is determined to uncover the mystery that resulted in the downfall of her family. As you turn the pages in the book, each series of memories, will open a different door, to the different homes, (Fifteen to be exact). *****. ABOUT JEANNE CLAIRE PROBST. Jeanne Claire Probst was born and raised in the New England state of Massachusetts, is retired an lives in Ludlow. She is excited to be fulfilling a life-long ...
https://betheladvocate.com/friends-just-understand-thought-and-poem-by-jeanne-claire-probst/?replytocom=172349
Friends Just Understand … Thought and Poem … by Jeanne Claire Probst - Bethel AdvocateFriends Just Understand … Thought and Poem … by Jeanne Claire Probst - Bethel Advocate
The Fifteen Houses, a Novel. The Fifteen Houses is the first book of this new and exciting series to be published. Staged in the beautiful and scenic palate of East Longmeadow, Massachusetts, in the early 1950s, the main character delves into her reoccurring and discomforting memories of her younger, formative years. Searching for answers to questions that have resurfaced in her mind over and over again during her time away from her family, she seeks to find rhyme and reasons to her insecurities, anger, phobias, fears, and lifes choices. Julianne Marguerite, one of eleven children, is determined to uncover the mystery that resulted in the downfall of her family. As you turn the pages in the book, each series of memories, will open a different door, to the different homes, (Fifteen to be exact). *****. ABOUT JEANNE CLAIRE PROBST. Jeanne Claire Probst was born and raised in the New England state of Massachusetts, is retired an lives in Ludlow. She is excited to be fulfilling a life-long ...
https://betheladvocate.com/friends-just-understand-thought-and-poem-by-jeanne-claire-probst/?replytocom=162803
Roger Probst B.B.A. | Chaplin School of Hospitality & Tourism Management | Florida International UniversityRoger Probst B.B.A. | Chaplin School of Hospitality & Tourism Management | Florida International University
Roger Probst is a Instructor at Florida International University, School of Hospitality and Tourism Management. Mr. Probst has extensive teaching business and trades associated ...
https://hospitality.fiu.edu/faculty/profiles/probst-roger--bba.html
Jeff Probst on episode 2 of Survivor: Philippines | EW.comJeff Probst on episode 2 of Survivor: Philippines | EW.com
Image credit: Monty Brinton/CBS[/caption] Each week, host Jeff Probst answers a few questions about the most recent episode of Survivor:…
http://www.ew.com/article/2012/09/27/jeff-probst-episode-2-survivor-philippines/
Under Construction by Norbert Probst |...Under Construction by Norbert Probst |...
Buy Under Construction by Norbert Probst as a Poster, Throw Pillow, Tote Bag, Studio Pouch, Art Print, Canvas Print, Framed Print, Photographic Print, Metal Print, Greeting Card, Laptop Skin, or Laptop Sleeve
https://www.redbubble.com/people/kameranobs/works/10636699-under-construction?ref=work_carousel_work_portfolio_1
Birds Love Photographic Prints by Norbert Probst |...Birds Love Photographic Prints by Norbert Probst |...
Buy Birds Love by Norbert Probst as a T-Shirt, Classic T-Shirt, Tri-blend T-Shirt, Lightweight Hoodie, Womens Fitted Scoop T-Shirt, Womens Fitted V-Neck T-Shirt, Womens Relaxed Fit T-Shirt, Womens Chiffon Top, Sticker, Poster, Throw ...
https://www.redbubble.com/people/kameranobs/works/9790745-birds-love?p=photographic-print
Survivors Jeff Probst: No Edge of Extinction for a whileSurvivors Jeff Probst: No Edge of Extinction for a while
After hearing constructive (and non-constructive) feedback from the Survivor community, showrunner Jeff Probst confirms Edge of Extinction will be shelved.
https://survivingtribal.com/2020/02/11/survivor-jeff-probst-no-edge-extinction/
Other Syndromes Frequently Associated with Callosal Agenesis | SpringerLinkOther Syndromes Frequently Associated with Callosal Agenesis | SpringerLink
More than 50 disorders associated with agenesis of the corpus callosum (ACC) have been reported in medical literature. In most cases, the association appears to be a chance occurrence. Some of the...
https://link.springer.com/chapter/10.1007/978-1-4613-0487-6_7
GATA4 Mutations Are a Cause of Neonatal and Childhood-Onset Diabetes | DiabetesGATA4 Mutations Are a Cause of Neonatal and Childhood-Onset Diabetes | Diabetes
Our study reports five patients with GATA4 mutations and a variable phenotype of transient or permanent diabetes diagnosed in neonates or during childhood. The exocrine pancreatic phenotype ranged from complete agenesis to hypoplasia with subclinical exocrine insufficiency or normal exocrine function. Additional features included neurocognitive defects and congenital heart malformations. The variable phenotype was not correlated with the size of the deletion, consistent with the variable penetrance of GATA4 mutations/deletions reported in the literature. Both patients with pancreatic agenesis (this study and DAmato et al. [11]) had missense mutations rather than deletions, but the absence of diabetes in two heterozygous relatives suggests that a dominant-negative effect is unlikely (11). Our results indicate that GATA4 mutations/deletions are a rare cause of NDM, accounting for 0.5% of our international series (4/867 cases). The observation that postzygotic GATA4 mutations in embryonic heart ...
http://diabetes.diabetesjournals.org/content/63/8/2888.full
Three de novo DDX3X variants associated with distinctive brain developmental abnormalities and brain tumor in intellectually...
TY - JOUR. T1 - Three de novo DDX3X variants associated with distinctive brain developmental abnormalities and brain tumor in intellectually disabled females. AU - TUDP consortium. AU - Scala, Marcello. AU - Torella, Annalaura. AU - Severino, Mariasavina. AU - Morana, Giovanni. AU - Castello, Raffaele. AU - Accogli, Andrea. AU - Verrico, Antonio. AU - Vari, Maria Stella. AU - Cappuccio, Gerarda. AU - Pinelli, Michele. AU - Vitiello, Giuseppina. AU - Terrone, Gaetano. AU - DAmico, Alessandra. AU - Nigro, Vincenzo. AU - Capra, Valeria. PY - 2019/8. Y1 - 2019/8. N2 - De novo DDX3X variants account for 1-3% of syndromic intellectual disability (ID) in females and have been occasionally reported in males. Furthermore, somatic DDX3X variants occur in several aggressive cancers, including medulloblastoma. We report three unrelated females with severe ID, dysmorphic features, and a common brain malformative pattern characterized by malformations of cortical development, callosal dysgenesis, basal ...
https://moh-it.pure.elsevier.com/en/publications/three-de-novo-ddx3x-variants-associated-with-distinctive-brain-de
Probst: A Sign of Lightweight ParityProbst: A Sign of Lightweight Parity
Benson Henderson (file photo) took it to Jim Miller. Photo: Jeff Sherwood It can be easy to get high on a fighter after a win and flee his bandwagon after a loss. If the Benson Henderson-Jim Miller co-main event at UFC Live 5 can serve as a reminder, it is that the stacked lightweight division is a case study in MMA Math rarely, if ever, adding up. MMA Math is the simple process of saying
http://www.sherdog.com/blog/Probst-A-Sign-of-Lightweight-Parity-34806
The One Incredibly Green Thing Donald Trump Has Done - POLITICOThe One Incredibly Green Thing Donald Trump Has Done - POLITICO
Implausible as it may sound, its not fully crazy to believe that the Trump administration has actually prioritized toxic cleanups. Kate Probst, an independent consultant and one of Superfunds longest-standing outside observers, said the program is likely the most palatable of all environmental options for this administration. Superfund is not a regulatory program. It is the only non-regulatory program at EPA-its a cleanup, she said. And if all politics is local, Superfund plays there too. Whether you are a Republican or a Democrat, if you live near a site, or youre a member of Congress with a site in your district, you want that site cleaned up, she added, noting that cleanups bring cash infusions into regions in the form of contract work for construction and remediation. Superfund, Probst said, is not the same as anything else at EPA.. The success during the Trump administration thus far, Gibbs organization, the Center for Health, Environment and Justice, wrote in a recent report, ...
https://www.politico.com/news/magazine/2020/09/07/superfund-activists-donald-trump-minden-wv-400921
014 Youre TOO Sweet! DKA Emergency w/Marc Probst, MD - RESUS NURSE014 Youre TOO Sweet! DKA Emergency w/Marc Probst, MD - RESUS NURSE
These patients are admitted to a step-down or an ICU unit for the amount of nursing required. Once the anion gap has closed and remains closed, and your patient is STILL in the ED - talk to the provider and consider changing the bed assignment (Med Surg) if youre still boarding this patient ...
https://resusnurse.com/2017/11/17/youre-sweet-dka-emergency-w-marc-probst-md/
Larry Probst | The Sport DigestLarry Probst | The Sport Digest
So you want to contribute to the Sport Digest? We welcome submissions from the public and alumni alike. Below are links to the information you need to know. Feel free to submit a request for any additional information you may need.. ...
http://thesportdigest.com/tag/larry-probst/
Welcome to Digital Mutations!
No part of publication on this Web site may be reproduced or transmitted in any form or by any means, or stored in any information storage and retrieval system without prior written permission from Claudia Probst & Michael Shpaizman ...
http://digitalmutations.de
Tunes of Blood & Iron - Volume 1 : German Regimental & Parade Marches from Frederick the Great to the Present Day by Luftwaffe...Tunes of Blood & Iron - Volume 1 : German Regimental & Parade Marches from Frederick the Great to the Present Day by Luftwaffe...
Tunes of Blood & Iron - Volume 1 : German Regimental & Parade Marches from Frederick the Great to the Present Day by Luftwaffe Lt Cols Joachim Toeche-Mittler and Werner Probst Volume 1 - Infantry (Par.
https://www.hive.co.uk/Product/Antony-Dean/Tunes-of-Blood--Iron---Volume-1--German-Regimental--Parad/14425224
Elzbieta JankowskaElzbieta Jankowska
In: J.H.J. Allum, D.J. Allum-Mecklenburg, F.P. Harris and R. Probst (eds). Natural and artificial control of hearing and balance. Progr. Brain Res., Elsevier, Amsterdam - London - New York -Tokyo, 97, 161-171. - 1993-01-01 ...
https://www.gu.se/om-universitetet/hitta-person/elzbietajankowska
Publications | Butcher LabPublications | Butcher Lab
Levine RA, Hagége AA, Judge DP, Padala M, Dal-Bianco JP, Aikawa E, Beaudoin J, Bischoff J, Bouatia-Naji N, Bruneval P, Butcher JT, Carpentier A, Chaput M, Chester AH, Clusel C, Delling FN, Dietz HC, Dina C, Durst R, Fernandez-Friera L, Handschumacher MD, Jensen MO, Jeunemaitre XP, Le Marec H, Le Tourneau T, Markwald RR, Mérot J, Messas E, Milan DP, Neri T, Norris RA, Peal D, Perrocheau M, Probst V, Pucéat M, Rosenthal N, Solis J, Schott JJ, Schwammenthal E, Slaugenhaupt SA, Song JK, Yacoub MH; Leducq Mitral Transatlantic Network ...
http://www.butcherlab.com/publications
Search Articles | University of Toronto Libraries
by Al-Batran, Salah-Eddin and Homann, Nils and Pauligk, Claudia and Goetze, Thorsten O and Meiler, Johannes and Kasper, Stefan and Kopp, Hans-Georg and Mayer, Frank and Haag, Georg Martin and Luley, Kim and Lindig, Udo and Schmiegel, Wolff and Pohl, Michael and Stoehlmacher, Jan and Folprecht, Gunnar and Probst, Stephan and Prasnikar, Nicole and Fischbach, Wolfgang and Mahlberg, Rolf and Trojan, Jörg and Koenigsmann, Michael and Martens, Uwe M and Thuss-Patience, Peter and Egger, Matthias and Block, Andreas and Heinemann, Volker and Illerhaus, Gerald and Moehler, Markus and Schenk, Michael and Kullmann, Frank and Behringer, Dirk M and Heike, Michael and Pink, Daniel and Teschendorf, Christian and Löhr, Carmen and Bernhard, Helga and Schuch, Gunter and Rethwisch, Volker and von Weikersthal, Ludwig Fischer and Hartmann, Jörg T and Kneba, Michael and Daum, Severin and Schulmann, Karsten and Weniger, Jörg and Belle, Sebastian and Gaiser, Timo and Oduncu, Fuat S and Güntner, Martina and Hozaeel, ...
https://query.library.utoronto.ca/index.php/search/q?kw=SubjectTerms:Capecitabine%20-%20administration%20&%20dosage
Search Articles | University of Toronto Libraries
by Hazen, Terry C and Dubinsky, Eric A and DeSantis, Todd Z and Andersen, Gary L and Piceno, Yvette M and Singh, Navjeet and Jansson, Janet K and Probst, Alexander and Borglin, Sharon E and Fortney, Julian L and Stringfellow, William T and Bill, Markus and Conrad, Mark E and Tom, Lauren M and Chavarria, Krystle L and Alusi, Thana R and Lamendella, Regina and Joyner, Dominique C and Spier, Chelsea and Baelum, Jacob and Auer, Manfred and Zemla, Marcin L and Chakraborty, Romy and Sonnenthal, Eric L and Dhaeseleer, Patrik and Holman, Hoi-Ying N and Osman, Shariff and Lu, Zhenmei and Van Nostrand, Joy D and Deng, Ye and Zhou, Jizhong and Mason, Olivia U ...
https://query.library.utoronto.ca/index.php/search/q?kw=Author:Lamendella,%20Regina
Phase III randomized, double-blind study of paclitaxel with and without everolimus in patients with advanced gastric or...Phase III randomized, double-blind study of paclitaxel with and without everolimus in patients with advanced gastric or...
Lorenzen, Sylvie; Knorrenschild, Jorge Riera; Pauligk, Claudia; Hegewisch-Becker, Susanna; Seraphin, Joerg; Thuss-Patience, Peter; Kopp, Hans-Georg; Dechow, Tobias; Vogel, Arndt; Luley, Kim Barbara; Pink, Daniel; Stahl, Michael; Kullmann, Frank; Hebart, Holger; Siveke, Jens; Egger, Matthias; Homann, Nils; Probst, Stephan; Goetze, Thorsten Oliver; Al-Batran, Salah-Eddin ...
https://publikationen.uni-tuebingen.de/xmlui/handle/10900/106697
Corpus callosum agenesis legal definition of Corpus callosum agenesisCorpus callosum agenesis legal definition of Corpus callosum agenesis
Definition of Corpus callosum agenesis in the Legal Dictionary - by Free online English dictionary and encyclopedia. What is Corpus callosum agenesis? Meaning of Corpus callosum agenesis as a legal term. What does Corpus callosum agenesis mean in law?
https://legal-dictionary.thefreedictionary.com/Corpus+callosum+agenesis
Donnai Barrow syndrome - CheckOrphanDonnai Barrow syndrome - CheckOrphan
The signs and symptom information on this page attempts to provide a list of some possible signs and symptoms of Diaphragmatic hernia - exomphalos - corpus callosum agenesis. This medical information about signs and symptoms for Diaphragmatic hernia - exomphalos - corpus callosum agenesis has been gathered from various sources, may not be fully accurate, and may not be the full list of Diaphragmatic hernia - exomphalos - corpus callosum agenesis signs or Diaphragmatic hernia - exomphalos - corpus callosum agenesis symptoms. Furthermore, signs and symptoms of Diaphragmatic hernia - exomphalos - corpus callosum agenesis may vary on an individual basis for each patient. Only your doctor can provide adequate diagnosis of any signs or symptoms and whether they are indeed Diaphragmatic hernia - exomphalos - corpus callosum agenesis symptoms. ...
https://checkorphan.org/disease/donnai-barrow-syndrome/
Isolated agenesis of the corpus callosum and normal general intelligence development during postnatal life: a case report and...Isolated agenesis of the corpus callosum and normal general intelligence development during postnatal life: a case report and...
Agenesis of the corpus callosum can occur isolated or as part of a complex congenital syndrome. Patients with isolated agenesis of the corpus callosum may present with severe intellectual disability, although a proportion of affected individuals develop normal intelligence. However, even in patients with no apparent deficits, subtle neuropsychological alterations may occur as the cognitive demand increases with age. Hence, patients with this deffect require a strict follow-up during their postnatal life. Thus, physicians require a better knowledge of the cognitive features of agenesis of the corpus callosum to improve their approach to this cerebral malformation. Here, we report an illustrative case of a school-age child with isolated agenesis of the corpus callosum and normal intelligence. We also provide a literature review about the postnatal screening of neurocognitive deficits in patients with agenesis of the corpus callosum. An 8-year-old Hispanic boy with total agenesis of the corpus callosum
https://jmedicalcasereports.biomedcentral.com/articles/10.1186/s13256-020-2359-2
SPG11 mutations cause Kjellin syndrome, a hereditary spastic paraplegia with thin corpus callosum and central retinal...SPG11 mutations cause Kjellin syndrome, a hereditary spastic paraplegia with thin corpus callosum and central retinal...
Autosomal recessive hereditary spastic paraplegia (ARHSP) with thin corpus callosum (TCC) is genetically heterogenous and approximately 35% of patients carry mutations in either of the SPG11 or SPG15 genes. Disease onset is during the first three decades of life with spastic paraplegia and mental impairment. Peripheral neuropathy and amyotrophy may occur. Kjellin syndrome is characterized by central retinal degeneration in addition to ARHSP-TCC and the disease is associated with mutations in the SPG15 gene. We identified five patients in four unrelated kindreds with spastic paraplegia and mental impairment. Magnetic resonance imaging revealed TCC, atrophy elsewhere in the brain and increased T2 signal intensity in the periventricular white matter. Probands from the four kindreds were screened for mutations in the SPG11 gene. All patients were found homozygous or compound heterozygous for truncating SPG11 mutations of which four are reported for the first time. Ophthalmological investigations ...
http://uu.diva-portal.org/smash/record.jsf?pid=diva2:221158
Spastizin mutation in hereditary spastic paraplegia with thin corpus callosum<...
TY - JOUR. T1 - Spastizin mutation in hereditary spastic paraplegia with thin corpus callosum. AU - Chakrabarty, Sanjiban. AU - Vijayakumar, Nimish. AU - Radhakrishnan, Kurupath. AU - Satyamoorthy, Kapaettu. PY - 2016/10/1. Y1 - 2016/10/1. UR - http://www.scopus.com/inward/record.url?scp=84982255216&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=84982255216&partnerID=8YFLogxK. U2 - 10.1007/s00415-016-8258-1. DO - 10.1007/s00415-016-8258-1. M3 - Letter. C2 - 27544497. AN - SCOPUS:84982255216. VL - 263. SP - 2130. EP - 2132. JO - Journal of Neurology. JF - Journal of Neurology. SN - 0340-5354. IS - 10. ER - ...
https://manipal.pure.elsevier.com/en/publications/spastizin-mutation-in-hereditary-spastic-paraplegia-with-thin-cor
National Organization of Disorders of the Corpus Callosum National Organization of Disorders of the Corpus Callosum » National...
Acrocallosal Syndrome: genetic disorder in which individuals have large heads, agenesis of the corpus callosum, and finger and toe differences (extra or too few). They usually have developmental delay. Augmentative Devices: tools that help individuals with limited or absent speech to communicate, such as communication boards, pictographs (symbols that look like the things they represent), ideographs (symbols representing ideas), and iPad apps.. Aicardi Syndrome: a genetic syndrome in which girls have agenesis of the corpus callosum, as well as eye and other brain development abnormalities. They usually have seizures and severe developmental delay. More information can be found at: http://www.aicardisyndrome.org. Amniocentesis procedure: in which a sample of fluid is drawn out of the uterus during pregnancy and tested for the presence of genetic abnormalities. Andermann Syndrome: a condition in which individuals (almost exclusively found in the certain part of Quebec) have agenesis of the corpus ...
https://nodcc.org/corpus-callosum-disorders/glossary/
Commissural fiber - WikipediaCommissural fiber - Wikipedia
Aging Age-related decline in the commissural fiber tracts that make up the corpus callosum indicate the corpus callosum is involved in memory and executive function. Specifically, the posterior fibers of the corpus callosum are associated with episodic memory. Perceptual processing decline is also related to diminished integrity of occipital fibers of the corpus callosum. Evidence suggests that the genu of the corpus callosum does not contribute significantly to any one cognitive domain in the elderly. As fiber tract connectivity in the corpus callosum declines due to aging, compensatory mechanisms are found in other areas of the corpus callosum and frontal lobe. These compensatory mechanisms, increasing connectivity in other parts of the brain, may explain why elderly individuals still display executive function as a decline of connectivity is seen in regions of the corpus callosum.[7] Older adults compared to younger adults show poorer performance in balance exercises and tests. A decline in ...
https://en.wikipedia.org/wiki/Commissural_fiber
Agenesis of the corpus callosum - OurMed
This condition occurs when the callosal fibers may have started to grow, but are unable to cross between the hemispheres. The fibers grow toward the back of the same hemisphere where they began. These fibers form what are called Bundles of Probst. Some smaller connections between the hemispheres develop in most individuals with ACC. These are the anterior commissure, posterior commissure, and hippocampal commissure. However, each of these is at least 40,000 times smaller than the corpus callosum. Thus, they cannot compensate completely for the absence of the corpus callosum. ...
http://ourmed.org/wiki/Agenesis_of_the_corpus_callosum
Around Town Archives - North Shore Pediatric TherapyAround Town Archives - North Shore Pediatric Therapy
left hemispheres of the brain together. Disorders of the corpus callosum, or DCCs, are conditions in which the corpus callosum does not develop in a typical manner. This important brain superhighway is usually formed by 12 to 16 weeks after conception. However, there are some people born without a corpus callosum at all, this is otherwise known as agenesis of the corpus callosum. My 4 year old son has hypoplasia of the corpus callosum, which means that his corpus callosum is thin and therefore may be less efficient. A few other included disorders are partial agenesis, as in partially absent, and dysgenesis, or malformation, of the corpus callosum.. DCCs, like Autism, are a spectrum disorder, where there is no textbook answer to how happy or healthy someone will be just based off of diagnosis. Many parents are finding out during pregnancy due to the advancement in technology and equipment. Unfortunately, they are not always getting the best advice or support, due to the lack of knowledge on ...
https://nspt4kids.com/category/around-town/
The Cavum Septi Pellucidi - myminifellowshipThe Cavum Septi Pellucidi - myminifellowship
Of note, in our study of the 112 neurologic anomalies, visualization of the cavum septi pellucidi did not increase sensitivity for detection ...
http://www.myminifellowship.com/the-cavum-septi-pellucidi.html
Surgical experiences of expanded symptomatic cavum septi pellucidi: Report of two cases - Fingerprint - Okayama University
Fingerprint Dive into the research topics of Surgical experiences of expanded symptomatic cavum septi pellucidi: Report of two cases. Together they form a unique fingerprint. ...
https://okayama.pure.elsevier.com/en/publications/surgical-experiences-of-expanded-symptomatic-cavum-septi-pellucid/fingerprints/
The midsagittal view of the fetal brain: a useful landmark in recognizing the cause of fetal cerebral ventriculomegaly :...The midsagittal view of the fetal brain: a useful landmark in recognizing the cause of fetal cerebral ventriculomegaly :...
Aim: To evaluate the positive predictive value of the midsagittal view of the fetal brain in recognizing the cause of ventriculomegaly diagnosed with traditional axial scan.. Methods: Fifty-eight pregnant women, referred to our Center following a generic diagnosis of ventriculomegaly have been evaluated: 38 had marked and 20 had borderline ventriculomegaly. The fetal brain was scanned by the midsagittal view using a transabdominal probe in fetuses in breech presentation or transverse lie and a transvaginal probe in fetuses in cephalic presentation. The possible cause of ventriculomegaly was postulated by combining the findings of the corpus callosum/cavum septi pellucidi complex with those of the posterior fossa. The prenatal diagnoses were compared with the anatomical specimens of aborted fetuses or with postnatal neuroimaging.. Results: The prenatal diagnoses were confirmed in 54/58 cases (PPV 93.1%). In the marked ventriculomegaly group, one case of partial agenesis of the corpus callosum was ...
https://www.degruyter.com/view/j/jpme.2005.33.issue-5/jpm.2005.075/jpm.2005.075.xml
National Organization of Disorders of the Corpus Callosum National Organization of Disorders of the Corpus Callosum » National...
I am a speech-language pathologist working with a first-grader with partial agenesis of the corpus callosum. He speaks in complete sentences and produces most sounds correctly. However, I have just begun working on his prosody. In our first session addressing voicing issues, he was unable to imitate/approximate exaggerated high and low pitch. His mother reports that he does not hum or sing tunes but he does make voices when playing independently with action figures. I have searched our ASHA professional website but did not find any therapy techniques or suggestions. Do you have any resources that might help me?. Response by JoAnne Tully CCC-SLP (2009). I dont know of any articles or discussions that have directly talked about prosody in children with DCC. I do know, however, that a lot of children with DCC have some degree of apraxia, and prosody disorders often accompany apraxia. The Apraxia-Kids website has a good article by Shelley Velleman about prosody. The link to that article is ...
https://nodcc.org/resources/ask-a-professional/
Regionally specific atrophy of the corpus callosum in AD, MCI and cognitive complaints<...
TY - JOUR. T1 - Regionally specific atrophy of the corpus callosum in AD, MCI and cognitive complaints. AU - Wang, Paul J.. AU - Saykin, Andrew J.. AU - Flashman, Laura A.. AU - Wishart, Heather A.. AU - Rabin, Laura A.. AU - Santulli, Robert B.. AU - McHugh, Tara L.. AU - MacDonald, John W.. AU - Mamourian, Alexander. PY - 2006/11/1. Y1 - 2006/11/1. N2 - The goal of the present study was to determine if there are global or regionally specific decreases in callosal area in early Alzheimers disease (AD) and mild cognitive impairment (MCI). In addition, this study examined the corpus callosum of healthy older adults who have subjective cognitive complaints (CC) but perform within normal limits on neuropsychological tests. We used a semi-automated procedure to examine the total and regional areas of the corpus callosum in 22 patients with early AD, 28 patients with amnestic MCI, 28 healthy older adults with cognitive complaints, and 50 demographically matched healthy controls (HC). The AD, MCI, ...
https://pennstate.pure.elsevier.com/en/publications/regionally-specific-atrophy-of-the-corpus-callosum-in-ad-mci-and-
Infants With Agenesis of the Corpus Callosum - Full Text View - ClinicalTrials.govInfants With Agenesis of the Corpus Callosum - Full Text View - ClinicalTrials.gov
Agenesis of the corpus callosum is the most frequent brain malformation. This anomaly may be diagnosed by ultrasound screening. In half of these prenatal cases, the anomaly seems to be isolated. In this setting, there are no prospective data concerning the development of these children, preventing any clear information to be delivered to parents. Prenatal diagnostic centers therefore face extremely variable rates of termination of pregnancies (TOP), which can reach up to 80%.. This is a multicentric prospective interventional study whose primary objective is to assess the neurological development at three years of age of children born after prenatal diagnosis of isolated agenesis of the corpus callosum.. Evaluation at three years will include Intellectual Quotient (IQ) quantification using the WPPSI-III, 3rd edition of Wechsler Preschool and Primary Scale of Intelligence and evaluation of intra-hemispheric coordination using the Vineland adaptative behaviour scale.. Secondary objectives will ...
https://www.clinicaltrials.gov/ct2/show/NCT02267161
Aicardi syndrome. Causes, symptoms, treatment Aicardi syndromeAicardi syndrome. Causes, symptoms, treatment Aicardi syndrome
Description of disease Aicardi syndrome. Treatment Aicardi syndrome. Symptoms and causes Aicardi syndrome Prophylaxis Aicardi syndrome
http://drugster.info/ail/pathography/401/
Cerebral hemisphere - WikipediaCerebral hemisphere - Wikipedia
If the upper part of either hemisphere be removed, at a level about 1.25 cm. above the corpus callosum, the central white matter will be exposed as an oval-shaped area, the centrum ovale minus, surrounded by a narrow convoluted margin of gray substance, and studded with numerous minute red dots (puncta vasculosa), produced by the escape of blood from divided bloodvessels.. If the remaining portions of the hemispheres be slightly drawn apart a broad band of white substance, the corpus callosum, will be observed, connecting them at the bottom of the longitudinal fissure; the margins of the hemispheres which overlap the corpus callosum are called the labia cerebri.. Each labium is part of the cingulate gyrus already described; and the slit-like interval between it and the upper surface of the corpus callosum is termed the callosal sulcus.. If the hemispheres be sliced off to a level with the upper surface of the corpus callosum, the white substance of that structure will be seen connecting the two ...
https://en.m.wikipedia.org/wiki/Brain_hemisphere
Agenesis of the Corpus Callosum with Peripheral Neuropathy - SNPediaAgenesis of the Corpus Callosum with Peripheral Neuropathy - SNPedia
Hereditary motor and sensory neuropathy with agenesis of the corpus callosum (HMSN/ACC or ACCPN), also known as Andermann Syndrome, a neurodevelopmental and neurodegenerative disorder, is characterized by severe progressive sensorimotor neuropathy with resulting hypotonia, areflexia, and amyotrophy and variable degrees of dysgenesis of the corpus callosum.NIH ACCPN is inherited as an autosomal recessive, through mutations in the SLC12A6 gene. Several SLC12A6 mutations leading to ACCPN have been identified, including: ...
https://www.snpedia.com/index.php/Agenesis_of_the_Corpus_Callosum_with_Peripheral_Neuropathy
Novel mutations including deletions of the entire OFD1 gene in 30 families with type 1 orofaciodigital syndrome - Danish...Novel mutations including deletions of the entire OFD1 gene in 30 families with type 1 orofaciodigital syndrome - Danish...
OFD1, now recognized as a ciliopathy, is characterized by malformations of the face, oral cavity and digits, and is transmitted as an X-linked condition with lethality in males. Mutations in OFD1 also cause X-linked Joubert syndrome (JBTS10) and Simpson-Golabi-Behmel syndrome type 2 (SGBS2). We have studied 55 sporadic and six familial cases of suspected OFD1. Comprehensive mutation analysis in OFD1 revealed mutations in 37 female patients from 30 families; 22 mutations have not been previously described including two heterozygous deletions spanning OFD1 and neighbouring genes. Analysis of clinical findings in patients with mutations revealed that oral features are the most reliable diagnostic criteria. A first, detailed evaluation of brain MRIs from seven patients with cognitive defects illustrated extensive variability with the complete brain phenotype consisting of complete agenesis of the corpus callosum, large single or multiple interhemispheric cysts, striking cortical infolding of gyri, ...
http://www.forskningsdatabasen.dk/catalog/234189485
Poster Presentation - ASN Events
MRI pituitary showed partial agenesis of the corpus callosum with absence of splenium and posterior body. The pituitary gland is of normal size. An incidental CT abdomen and pelvis done 3 weeks later for symptoms suggestive of bowel obstruction revealed no pathology in the adrenals.. This may be a case of idiopathic adrenocorticotropin deficiency. Patients were typically over 40 years, hypogonadism may be present and there is absence of structural pituitary defects except for an empty sella1. It can also be associated with a transient growth hormone deficiency6. The partial agenesis of the corpus callosum is likely to be an incidental finding.. Some studies have shown increased biochemical adrenal insufficiency and prevalence of adrenal antibodies in patients with type 1 diabetes2,3whereas others did not show significant increase in prevalence compared with control subjects4,5. Testing for anti-adrenal antibodies would be necessary to completely rule out coexisting primary adrenal ...
http://ads-adea-2014.p.asnevents.com.au/days/2014-08-28/abstract/18328
Jane E. Probst - Wauwatosa, Wisconsin Lawyer - JustiaJane E. Probst - Wauwatosa, Wisconsin Lawyer - Justia
Wauwatosa, Wisconsin attorney Jane E. Probst. Legal practice includes family law, divorce and estate planning. Research legal experience, education, social media, awards, publications, professional associations, jurisdictions and contact information on Justia.
https://lawyers.justia.com/lawyer/jane-e-probst-1484227
HIStalk Interviews Marc Probst, VP/CIO, Intermountain Healthcare | HIStalkHIStalk Interviews Marc Probst, VP/CIO, Intermountain Healthcare | HIStalk
Marc Probst is VP/CIO at of Salt Lake City, UT. You have a history of speaking out about Meaningful Use. How has your opinion of it changed over the last
http://histalk2.com/2016/02/01/histalk-interviews-marc-probst-vpcio-intermountain-healthcare/
Spina Bifida Research Bibliography: Peripersonal spatial attention in children with spina bifidaSpina Bifida Research Bibliography: Peripersonal spatial attention in children with spina bifida
Horizontal and vertical line bisection was studied in 129 children and adolescents between 8 and 19 years of age, one group (n=32) of typically developing controls and one group (n=97) with spina bifida (SBM), a neurodevelopmental disorder associated with dysmorphology of the corpus callosum, posterior cortex, and midbrain. For each participant, structural brain MRIs were analyzed qualitatively to identify beaking of the midbrain tectum and corpus callosum agenesis and hypoplasia and quantitatively by segmentation and volumetric analyses of regional cortical white and gray matter. Each group showed the line length effect, whereby greater estimation errors are made with longer lines. The group with SBM differed from controls in terms of both accuracy and variability of line bisection. Children with SBM showed pseudoneglect, attending more than controls to left hemispace. The extent of rightward bisection bias was unrelated to right posterior brain volumes, although an intact corpus callosum ...
http://spina-bifida-bibliography.blogspot.com/2007/07/dennis-m-edelstein-k-frederick-j.html
Binocularity in the visual cortex of the adult cat does not depend on the integrity of the corpus callosum. | IRIS Università...Binocularity in the visual cortex of the adult cat does not depend on the integrity of the corpus callosum. | IRIS Università...
The importance of the corpus callosum for binocular interaction in areas 17 and 18 of the adult cat is still a matter of controversy, since its specific role in integrating information from the two eyes has been suggested by some and questioned by others. We have reanalyzed the problem by assessing binocular interaction for single neurons in areas 17 and 18 of adult cats submitted to section of the posterior two-thirds of the corpus callosum. In 5 cats this interhemispheric disconnection was performed from 10 days to 7 weeks before the electrophysiological recordings; in another cat callosal afferents to the recording sites were at first partially eliminated by an acute lesion of corresponding cortical zones in the other hemisphere, and thereafter completely interrupted by a posterior callosal section performed in the same recording session. Recordings were mainly aimed at the callosal zone of areas 17 and 18, which coincides with the border between these two areas and corresponds to visual ...
https://flore.unifi.it/handle/2158/253845
CORPUS CALLOSUM AND A MATURATIONAL PINNACLE
Here is a rendering of the corpus callosum with some of the grey matter stripped away in order to reveal how extensive its fibers are throughout the cerebral hemispheres. The corpus callosum is a large system of nerve fibers connecting the right and left hemispheres. We know something about its functioning through the split-brain operation,…
https://biologicalrootsofhumanity.wordpress.com/2013/12/16/corpus-callosum-and-a-maturational-pinnacle/
Psych-Brain-Trust - Corpus Callosum
The corpus callosum is a thick band of nerve fibers that is located at the center of the brain underneath the cerebrum and divides the brain into left and right hemispheres. It allows both sides of the brain to communicate by transferring sensory, cognitive, and motor information between the two hemispheres. The corpus callosum is also involved with eye movement and maintaining the balance of attention and arousal. It changes structurally throughout ones life especially during childhood and adolescence. ...
http://psych-brain-trust.wikispaces.com/Corpus+Callosum?responseToken=0f2da534c5eb4440168ffc6e0953e2f19
Tumor of corpus callosum - RightDiagnosis.comTumor of corpus callosum - RightDiagnosis.com
Tumor of corpus callosum symptoms, causes, diagnosis, and treatment information for Tumor of corpus callosum (Bristowes syndrome) with alternative diagnoses, full-text book chapters, misdiagnosis, research treatments, prevention, and prognosis.
http://www.rightdiagnosis.com/medical/tumor_of_corpus_callosum.htm
Aicardi syndromeAicardi syndrome
Also known as: agenesis of corpus callosum with chorioretinal abnormality, agenesis of corpus callosum with infantile spasms and ocular abnormalities, Aicardis syndrome, callosal agenesis and ocular abnormalities, chorioretinal anomalies with ACC ...
https://rarediseases.oscar.ncsu.edu/disease/aicardi-syndrome/
FOXG1 UK Charity
FOXG1 Syndrome. FOXG1 Syndrome is a rare neuro-developmental condition associated with mutations in the forkhead box G1 (FOXG1) gene. A de novo pathogenic variant in FOXG1 was first discovered via fluorescence in situ hybridization and southern blot hybridization in a girl with severe cognitive disability associated with complete agenesis of the corpus callosum and microcephaly in 2005. The FOXG1 gene provides instructions for making a protein known as forkhead box G1. This protein is a transcription factor, which means it helps regulate the activity of other genes. This protein plays an important role in brain development, particularly in a region of the embryonic brain known as the telencephalon. The telencephalon ultimately develops into several critical structures, including the the largest part of the brain (the cerebrum), which controls most voluntary activity, language, sensory perception, learning, and memory.. Typical Symptoms. There is a wide variation in both the symptoms and severity ...
http://www.foxg1.uk/foxg1syndrome.html
NINDS Agenesis of the Corpus Callosum Information Page: NINDS - RightDiagnosis.comNINDS Agenesis of the Corpus Callosum Information Page: NINDS - RightDiagnosis.com
Medical article NINDS Agenesis of the Corpus Callosum Information Page NINDS including all symptom, diagnosis, misdiagnosis, treatment and prevention information.
http://www.rightdiagnosis.com/artic/ninds_agenesis_of_the_corpus_callosum_information_page_ninds.htm
agenesis of the corpus callosum with peripheral neuropathy Disease Ontology Browser - DOID:0090003agenesis of the corpus callosum with peripheral neuropathy Disease Ontology Browser - DOID:0090003
There are currently no human or mouse genes associated with this disease in the MGI database. Synonyms: Andermann syndrome; Charlevoix disease; corpus callosum agenesis-neuronopathy syndrome
http://www.informatics.jax.org/disease/218000
Wnt/calcium signaling mediates axon growth and guidance in the developing corpus callosumWnt/calcium signaling mediates axon growth and guidance in the developing corpus callosum
It has been shown in vivo that Wnt5a gradients surround the corpus callosum and guide callosal axons after the midline (postcrossing) by Wnt5a-induced repulsion via Ryk receptors. In dissociated cortical cultures we showed that Wnt5a simultaneously promotes axon outgrowth and repulsion by calcium si …
https://pubmed.ncbi.nlm.nih.gov/20936661/
Split brains, autism and schizophrenia
One final note: formation of the corpus callosum is a dramatic example of a process that is susceptible to developmental variation. What I mean is this: when patients inherit a mutation that results in callosal agenesis, this phenotype occurs in some patients but not all. This is true even in genetically identical people, like monozygotic twins or triplets (or in lines of genetically identical mice). Though the corpus callosum contains millions of nerve fibres, the initial events that establish it involve very small numbers of cells. These cells, which are located at the medial edge of each cerebral hemisphere, must contact each other to enable the fusion of the two hemispheres, forming a tiny bridge through which the first callosal fibres can cross. Once these are across, the rest seem able to follow easily. Because this event involves very few cells at a specific time in development, it is susceptible to random noise - fluctuations in the precise amounts of various proteins in the cells, for ...
http://www.wiringthebrain.com/2011/08/split-brains-autism-and-schizophrenia.html?spref=tw
Template:ICD-11 Neural anomalies header table - Embryology
LA05 Cerebral structural developmental anomalies - LA05.0 Microcephaly, LA05.1 Megalencephaly, LA05.2 Holoprosencephaly, LA05.3 Corpus callosum agenesis, LA05.4 Arhinencephaly, LA05.5 Abnormal neuronal migration, LA05.6 Encephaloclastic disorders, LA05.7 Brain cystic ...
https://embryology.med.unsw.edu.au/embryology/index.php/Template:ICD-11_Neural_anomalies_header_table
Toriello-Carey Syndrome | Syndromes: Rapid Recognition and Perioperative Implications, 2e | AccessAnesthesiology | McGraw-Hill...Toriello-Carey Syndrome | Syndromes: Rapid Recognition and Perioperative Implications, 2e | AccessAnesthesiology | McGraw-Hill...
Laryngeal hypoplasia is the most common laryngeal anomaly described. Tracheal intubation for respiratory failure as a consequence of hypotonia may be necessary in the neonatal period. Cerebellar and brain stem hypoplasia are described in addition to corpus callosum agenesis. Seizures have been a feature in some patients. Mental retardation may be severe. Congenital heart disease appears to be a common, although inconsistent, finding. Vertebral malformations, supernumerary ribs, malformation of the clavicles are observed on occasion. Death in the neonatal period is common, especially among boys. ...
https://accessanesthesiology.mhmedical.com/content.aspx?bookid=2674§ionid=220546183
Toriello-Carey Syndrome | Syndromes: Rapid Recognition and Perioperative Implications, 2e | AccessPediatrics | McGraw-Hill...Toriello-Carey Syndrome | Syndromes: Rapid Recognition and Perioperative Implications, 2e | AccessPediatrics | McGraw-Hill...
Laryngeal hypoplasia is the most common laryngeal anomaly described. Tracheal intubation for respiratory failure as a consequence of hypotonia may be necessary in the neonatal period. Cerebellar and brain stem hypoplasia are described in addition to corpus callosum agenesis. Seizures have been a feature in some patients. Mental retardation may be severe. Congenital heart disease appears to be a common, although inconsistent, finding. Vertebral malformations, supernumerary ribs, malformation of the clavicles are observed on occasion. Death in the neonatal period is common, especially among boys. ...
https://accesspediatrics.mhmedical.com/content.aspx?bookid=2674§ionid=220546183
Molecular characterization of near-complete trisomy 17p syndrome from inverted duplication in association with cryptic deletion...Molecular characterization of near-complete trisomy 17p syndrome from inverted duplication in association with cryptic deletion...
Trisomy of the short arm of chromosome 17 (T17P) is a genomic disorder presenting with growth retardation, motor and mental retardation and constitutional physical anomalies including congenital heart defects. Here we report a case of near-complete T17P of which the genomic dosage aberrations were delineated by chromosomal microarray along with conventional diagnostic modalities. A 9-year-old Korean boy was admitted because of esophageal obstruction. He showed clinical manifestations of T17P, along with atypical features of scoliosis, corpus callosum agenesis, and seizure. Chromosome analyses revealed an inverted duplication of the chromosomal segment between 17p11.2 and 17p13.3. Chromosomal microarray revealed a duplication of the most of the short arm of chromosome 17 (size ~19.09 Mb) along with a cryptic deletion of a small segment of 17p terminal end (17pter) (~261 Kb). This is the first report of molecular characterization of near-complete T17P from inverted duplication in association with 17pter
https://www.semanticscholar.org/paper/Molecular-characterization-of-near-complete-trisomy-Park-Kim/5e9330d18cacb27349dbb3e5e6e0fe30f85f1c8d
Corpus callosum | Radiology Reference Article | Radiopaedia.orgCorpus callosum | Radiology Reference Article | Radiopaedia.org
The corpus callosum (plural: corpora callosa) is the largest of the commissural fibers, linking the cerebral cortex of the left and right cerebral hemispheres. It is the largest white matter tract in the brain. Summary located inferior to the c...
https://radiopaedia.org/articles/corpus-callosum?lang=us
Neuroanatomical Diversity of Corpus Callosum and Brain Volume in Autism: Meta-analysis, Analysis of the Autism Brain Imaging...Neuroanatomical Diversity of Corpus Callosum and Brain Volume in Autism: Meta-analysis, Analysis of the Autism Brain Imaging...
BACKGROUND Patients with autism have been often reported to have a smaller corpus callosum (CC) than control subjects. METHODS We conducted a meta-analysis of the literature, analyzed the CC in 694 subjects of the Autism Brain Imaging Data Exchange project, and performed computer simulations to study the effect of different analysis strategies. RESULTS Our meta-analysis suggested a group difference in CC size; however, the studies were heavily underpowered (20% power to detect Cohens d = .3). In contrast, we did not observe significant differences in the Autism Brain Imaging Data Exchange cohort, despite having achieved 99% power. However, we observed that CC scaled nonlinearly with brain volume (BV): large brains had a proportionally smaller CC. Our simulations showed that because of this nonlinearity, CC normalization could not control for eventual BV differences, but using BV as a covariate in a linear model would. We also observed a weaker correlation of IQ and BV in cases compared with control
https://www.semanticscholar.org/paper/Neuroanatomical-Diversity-of-Corpus-Callosum-and-in-Lefebvre-Beggiato/3acb972a9a16151ea611e890352bdfeef44afe9e
Brain - Insula and Corpus Callosum - Check123, Video Encyclopedia
Watch this video and learn all about Brain - Insula and Corpus Callosum. Amazing facts about anatomy and central nervous system in 1, 2 or 3 minute videos!
http://check123.com/videos/2704-brain-insula-and-corpus-callosum?source=carousel
Cytotoxic Lesions of the Corpus Callosum That Show Restricted Diffusion: Mechanisms, Causes, and ManifestationsCytotoxic Lesions of the Corpus Callosum That Show Restricted Diffusion: Mechanisms, Causes, and Manifestations
Cytotoxic lesions of the corpus callosum (CLOCCs) are secondary lesions associated with various entities. CLOCCs have been found in association with drug therapy, malignancy, infection, subarachnoid hemorrhage, metabolic disorders, trauma, and other entities. In all of these conditions, cell-cytokin …
https://pubmed.ncbi.nlm.nih.gov/28165876/?dopt=Abstract
Parkinsons Disease: Brain: Corpus Callosum - NB820-59410 | acris-antibodies.com
Parkinsons Disease: Brain: Corpus Callosum, 1 mg. Tissue total protein is prepared from whole tissue homogenates and presents a consistent pattern on SDS-PAGE analysis.
https://www.acris-antibodies.com/lysates/parkinsons-disease-brain-corpus-callosum-nb820-59410.htm
Acculturation to global consumer culture : a generational cohort comparison - StrathprintsAcculturation to global consumer culture : a generational cohort comparison - Strathprints
While on a global scale consumers are becoming more homogeneous, as a result of the increasingly globalized marketplace, researchers suggest that consumers within individual countries are becoming more culturally heterogeneous. Consequently, M. Cleveland and J. Laroche (2007. Acculturation to the global consumer culture: Scale development and research paradigm. Journal of Business Research, 60, 249-259) advocate segmenting consumers across markets on the basis of acculturation to the global consumer culture (AGCC) rather than segmenting at the individual country level. In this they anticipate AGCC will reflect demographic characteristics. However, little empirical work exists to validate or challenge the assertion that demographics moderate AGCC. This exploratory study uses generational cohort theory (GCT) to examine the relationships between cohort membership and level of AGCC among a sample of US consumers (N = 492). The findings suggest AGCC does identify differences between cohorts.. ...
https://strathprints.strath.ac.uk/44873/
Aicardi Syndrome: Causes, Symptoms and DiagnosisAicardi Syndrome: Causes, Symptoms and Diagnosis
Aicardi syndrome is a rare disorder that interferes with the formation of the corpus callosum. Learn about its symptoms, causes, and diagnosis.
https://www.healthline.com/health/aicardi-syndrome
What is Aicardi Syndrome?What is Aicardi Syndrome?
Aicardi syndrome is a rare genetic condition that mainly affects newly born females. The condition is characterized by a partial or complete absence of an important brain structure called the corpus callosum, which connects the two halves of the brain.
https://www.news-medical.net/health/What-is-Aicardi-Syndrome.aspx
WFPsychology62 - Brain-Corpus Callosum
Corpus Callosum - a thick band of nerve fibers that divides the cerebrum into left and right hemispheres. It connects the left and right sides of the brain allowing for communication between both hemispheres. The corpus callosum transfers motor, sensory, and cognitive information between the brain hemispheres ...
http://wfpsychology62.wikispaces.com/Brain-Corpus+Callosum?responseToken=64b2844ac38ab40bd412b440f5315f9a
Neurodevelopmental Disorder with Hypotonia and Variable Intellectual and Behavioral Abnormalities disease: Malacards - Research...Neurodevelopmental Disorder with Hypotonia and Variable Intellectual and Behavioral Abnormalities disease: Malacards - Research...
OMIM : 56 Neurodevelopmental disorder with hypotonia and variable intellectual and behavioral abnormalities (NEDHIB) is characterized by early-onset hypotonia, delayed walking, poor speech, and impaired intellectual development. Additional features may include feeding difficulties, dysmorphic features, and visual defects. Brain imaging tends to show delayed myelination, thin corpus callosum, and/or enlarged ventricles. The severity of the disorder is highly variable; initial evidence suggests that the severity may depend on the type of mutation (summary by Haijes et al., 2019). (618603) ...
https://www.malacards.org/card/neurodevelopmental_disorder_with_hypotonia_and_variable_intellectual_and_behavioral_abnormalities
The Delineation of an Interdisciplinary Speciality in terms of a Journal Set: The Case of Communication StudiesThe Delineation of an Interdisciplinary Speciality in terms of a Journal Set: The Case of Communication Studies
Loet Leydesdorff. Amsterdam School of Communications Research (ASCoR), University of Amsterdam, Kloveniersburgwal 48, 1012 CX Amsterdam, The Netherlands; [email protected]; http://www.leydesdorff.net &. Carole Probst. Faculty of Communication Sciences, Universit della Svizzera italiana,. Switzerland; [email protected] Abstract. A journal set in an interdisciplinary or newly developing area can be determined by including the journals classified under the most relevant ISI Subject Categories into a journal-journal citation matrix. Despite the fuzzy character of borders, factor analysis of the citation patterns enables us to delineate the specific set by discarding the noise. This methodology is illustrated using communication studies as a hybrid development between political science and social psychology. The development can be visualized using animations which support the claim that a specific journal set in communication studies is increasingly developing, notably in the being cited ...
https://www.leydesdorff.net/commstudies/index.htm
How can my sons developmental delay be managed?How can my sons developmental delay be managed?
My 13 months old son is suffering from |b|microcephaly with agenesis of corpus callosum|/b|. His weight is only 5.3 kg. How can he gain some weight? Is there any treatment for this problem? He sits with support but is not able to hold his head up and is unable to roll over. Is there any chance to grow the corpus callosum?
https://doctor.ndtv.com/faq/how-can-my-son-s-developmental-delay-be-managed-26374
Agenesis of the corpus callosumAgenesis of the corpus callosum
... (ACC) is a rare birth defect in which there is a complete or partial absence of the corpus ... "Corpus callosum disorders". National Organization for Disorders of the Corpus Callosum. Retrieved April 11, 2010. Badano JL, ... was born with agenesis of the corpus callosum, along with macrocephaly and damage to the cerebellum. "ACC - What is agenesis of ... Agenesis of the corpus callosum is one such disease, part of an emerging class of diseases called ciliopathies. The underlying ...
https://en.wikipedia.org/wiki/Agenesis_of_the_corpus_callosum
MASA syndromeMASA syndrome
... agenesis of the corpus callosum, a rare congenital disorder. It is characterized by a partial or complete absence (agenesis) of ... "Agenesis of Corpus Callosum". NORD (National Organization for Rare Disorders). Retrieved 2020-04-30. Bissonnette, Bruno; ... Fransen E, Lemmon V, Van Camp G, Vits L, Coucke P, Willems PJ (1995). "CRASH syndrome: clinical spectrum of corpus callosum ... The patient was a 10-year-old boy with symptoms like, mild mental retardation, bilateral adducted thumbs and corpus callosum ...
https://en.wikipedia.org/wiki/MASA_syndrome
X-linked complicated corpus callosum dysgenesisX-linked complicated corpus callosum dysgenesis
"X-linked complicated corpus callosum agenesis". RESERVED, INSERM US14-- ALL RIGHTS. "Orphanet: X linked complicated corpus ... X-linked complicated corpus callosum dysgenesis is a genetic disorder characterized by dysplasia, hypoplasia or agenesis of the ... "Entry - #304100 - CORPUS CALLOSUM, PARTIAL AGENESIS OF, X-LINKED - OMIM". omim.org. Retrieved 2022-09-06. "L1 syndrome: ... CT scans showed only corpus callosum agenesis. His head circumference at the time was 52 cm. Chromosomal analysis done on the ...
https://en.wikipedia.org/wiki/X-linked_complicated_corpus_callosum_dysgenesis
List of OMIM disorder codesList of OMIM disorder codes
CSPG6 Corpus callosum, agenesis of, with mental retardation, ocular coloboma and micrognathia; 300472; IGBP1 Corpus callosum, ... GATM Agenesis of the corpus callosum with peripheral neuropathy; 218000; SLC12A6 Aicardi-Goutières syndrome 1, dominant and ... MSX1 Tooth agenesis, selective, 3; 604625; PAX9 Tooth agenesis, selective, 6; 613097; LTBP3 Tooth agenesis, selective, X-linked ... UPK3A Renal agenesis; 191830; RET Renal carcinoma, chromophobe, somatic; 144700; FLCN Renal cell carcinoma; 144700; DIRC2 Renal ...
https://en.wikipedia.org/wiki/List_of_OMIM_disorder_codes
Andermann syndromeAndermann syndrome
"Familial agenesis of the corpus callosum with anterior horn cell disease: a syndrome of mental retardation, areflexia, and ... "AGENESIS OF THE CORPUS CALLOSUM WITH PERIPHERAL NEUROPATHY; ACCPN". www.omim.org. Retrieved 2017-01-19. RESERVED, INSERM US14 ... "Orphanet: Corpus callosum agenesis neuronopathy syndrome". www.orpha.net. Retrieved 2017-01-19. Dupré, Nicolas; Howard, Heidi C ... Andermann syndrome, also known as agenesis of corpus callosum with neuronopathy (ACCPN) and Charlevoix disease, among other ...
https://en.wikipedia.org/wiki/Andermann_syndrome
Joubert syndromeJoubert syndrome
August 2016). "MKS1 mutations cause Joubert syndrome with agenesis of the corpus callosum". European Journal of Medical ... "Joubert syndrome with associated corpus callosum agenesis". European Journal of Paediatric Neurology. 6 (1): 63-6. doi:10.1053/ ... Severe forms have been noted to include hypoplasia of the corpus callosum. Those with this syndrome often exhibit specific ... Joubert M, Eisenring JJ, Robb JP, Andermann F (September 1969). "Familial agenesis of the cerebellar vermis. A syndrome of ...
https://en.wikipedia.org/wiki/Joubert_syndrome
Ganglionic eminenceGanglionic eminence
This notably includes agenesis of the corpus callosum. Disturbances in the genesis of neural elements can result in cortical ...
https://en.wikipedia.org/wiki/Ganglionic_eminence
Warren S. BrownWarren S. Brown
... he has been studying the implications of agenesis of the corpus callosum (i.e., congenital absence of the corpus callosum, the ... Brown, W.S., Anderson, L., Symington, M.F. and Paul, L.K.(2012) Decision-Making in Agenesis of the Corpus Callosum: Expectancy- ... Brown, W.S. and Paul L.K., (2000) Psychosocial deficits in agenesis of the corpus callosum with normal intelligence. Cognitive ... "Travis Research Institute - Agenesis of the Corpus Callosum". Travis Research Institute. 2011. Retrieved 21 January 2015. - ...
https://en.wikipedia.org/wiki/Warren_S._Brown
Corpus callosumCorpus callosum
... was found with agenesis of the corpus callosum, as part of FG syndrome. Anterior corpus callosum lesions may result in akinetic ... MRI of the brain at the level of the caudate nuclei emphasizing corpus callosum Tractography of Corpus callosum Corpus callosum ... Part of the corpus callosum forms the roof of the lateral ventricles. The corpus callosum has four main parts - individual ... The trunk of the corpus callosum lies between the splenium and the genu. The callosal sulcus separates the corpus callosum from ...
https://en.wikipedia.org/wiki/Corpus_callosum
Lujan-Fryns syndromeLujan-Fryns syndrome
A correlation between agenesis of the corpus callosum and intellectual disability in LFS, however, has not been suggested. ... A relatively common brain anomaly seen with LFS is agenesis of the corpus callosum, an error of embryonic development in which ... Some features found in LFS, like agenesis of the corpus callosum and cartilage-related craniofacial anomalies, are similar to ... corpus callosum agenesis and hypotonia. Notable features of FGS that have not been reported with LFS include excessive ...
https://en.wikipedia.org/wiki/Lujan–Fryns_syndrome
Frederick AndermannFrederick Andermann
Familial agenesis of corpus callosum with anterior horn cell disease. Trans Am Neurol Assoc 1972; 97: 242-244 Andermann E, ...
https://en.wikipedia.org/wiki/Frederick_Andermann
Proud syndromeProud syndrome
"OMIM Entry - # 300004 - CORPUS CALLOSUM, AGENESIS OF, WITH ABNORMAL GENITALIA". www.omim.org. Retrieved 2022-06-13. Proud, V. K ... The following list comprises the symptoms this disorder causes: Corpus callosum agenesis Severe intellectual disabilities: IQ ... and agenesis of the corpus callosum". American Journal of Medical Genetics. 43 (1-2): 458-466. doi:10.1002/ajmg.1320430169. ... corpus callosum agenesis, epilepsy, and spasticity. It is a type of syndromic X-linked intellectual disability. ...
https://en.wikipedia.org/wiki/Proud_syndrome
Halperin-Birk syndromeHalperin-Birk syndrome
Brain MRI demonstrated microcephaly and agenesis of the corpus callosum. The syndrome was first described in 2019 by Daniel ... Seizures Pseudobulbar palsy EEG abnormalities Semilobar holoprosencephaly seen on brain MRI Absent corpus callosum Colpocephaly ...
https://en.wikipedia.org/wiki/Halperin-Birk_syndrome
Developmental disorderDevelopmental disorder
A study also found that 33% of people who have AgCC (agenesis of the corpus callosum), a condition in which the corpus callosum ... "Autism traits in individuals with agenesis of the corpus callosum". Journal of Autism and Developmental Disorders. 43 (5): 1106 ... The corpus callosum, the band of nerve fibers, that connects the left and right hemispheres of the brain also gets affected in ...
https://en.wikipedia.org/wiki/Developmental_disorder
Empathising-systemising theoryEmpathising-systemising theory
... agenesis of corpus callosum). It was found that autism is commonly diagnosed in children where the corpus callosum does not ... May 2013). "Autism traits in individuals with agenesis of the corpus callosum". Journal of Autism and Developmental Disorders. ... of children with agenesis of the corpus callosum). A further example of brain structures relating to ASD is that children with ... A further example of how brain structure can influence ASD is looking at cases where the corpus callosum does not fully develop ...
https://en.wikipedia.org/wiki/Empathising–systemising_theory
Child psychopathologyChild psychopathology
Agenesis of the corpus callosum (ACC) is used to determine the frequency of social and behavioral problems in children with a ... For younger children, ages two to five, Agenesis of the corpus callosum causes problems in sleep. Sleep is critical for ... "Social and behavioral problems of children with agenesis of the corpus callosum". Child Psychiatry and Human Development. 38 (4 ... ACC is described as a defect in the brain where the 200 million axons that make the corpus callosum are either completely ...
https://en.wikipedia.org/wiki/Child_psychopathology
Saal Bulas syndromeSaal Bulas syndrome
... and agenesis of the corpus callosum". Clinical Dysmorphology. 4 (3): 246-50. PMID 7551162. Orpha.net - A listing of Rare ... This syndrome consists of ectrodactyly or lobster-like hands, diaphragmatic hernia and absence of the corpus callosum. In ...
https://en.wikipedia.org/wiki/Saal_Bulas_syndrome
Fetal warfarin syndromeFetal warfarin syndrome
... and agenesis of the corpus callosum. These defects contribute to the appearance of significant intellectual disability in 31% ...
https://en.wikipedia.org/wiki/Fetal_warfarin_syndrome
Spatial hearing lossSpatial hearing loss
The corpus callosum (CC) is the major route of communication between the two hemispheres. At maturity it is a large mass of ... callosal agenesis, or hemispherectomy; Brain Res Cogn Brain Res 25(2), 2005 Bamiou D et al.; Auditory interhemispheric transfer ... With children the underdeveloped Corpus Callosum (CC) is unable, in any case, to transfer auditory streams arriving (from the ... Cocktail party effect Corpus callosum Presbycusis Spatial hearing Unilateral hearing loss SoundBite Hearing System Cameron S ...
https://en.wikipedia.org/wiki/Spatial_hearing_loss
Electroneutral cation-ClElectroneutral cation-Cl
Defects in KCC3 are linked to agenesis of the corpus callosum with peripheral neuropathy. This disorder is characterised by ... dysmorphic features and complete or partial agenesis of the corpus callosum. Gillen CM, Brill S, Payne JA, Forbush B (July 1996 ... "The K-Cl cotransporter KCC3 is mutant in a severe peripheral neuropathy associated with agenesis of the corpus callosum". Nat. ...
https://en.wikipedia.org/wiki/Electroneutral_cation-Cl
Gómez-López-Hernández syndromeGómez-López-Hernández syndrome
A reduced corpus callosum is present in some cases (agenesis of the corpus callosum). Gómez-López-Hernández syndrome is ... Choudhri AF, Patel RM, Wilroy RS, Pivnick EK, Whitehead MT (2015). "GTrigeminal nerve agenesis with absence of foramina rotunda ...
https://en.wikipedia.org/wiki/Gómez–López-Hernández_syndrome
ColpocephalyColpocephaly
partial or complete agenesis of the corpus callosum intellectual disability motor abnormalities visual defects such as, ... Corpus callosum is the band of white matter connecting the two cerebral hemispheres. The corpus callosum plays an extremely ... The partial or complete absence of white matter, also known as agenesis of the corpus callosum results in anatomic ... It is a nonspecific finding and is associated with multiple neurological syndromes, including agenesis of the corpus callosum, ...
https://en.wikipedia.org/wiki/Colpocephaly
CDK13-related disorderCDK13-related disorder
Some individuals have had agenesis of the corpus callosum or aplasia of the cerebellar vermis. This can sometimes manifest with ...
https://en.wikipedia.org/wiki/CDK13-related_disorder
SLC12A6SLC12A6
2002). "The K-Cl cotransporter KCC3 is mutant in a severe peripheral neuropathy associated with agenesis of the corpus callosum ... Mutations in this gene are associated with agenesis of the corpus callosum with peripheral neuropathy. Solute carrier family ... GeneReview/NIH/UW entry on Hereditary Motor and Sensory Neuropathy with Agenesis of the Corpus Callosum Race JE, Makhlouf FN, ...
https://en.wikipedia.org/wiki/SLC12A6
Vici syndromeVici syndrome
1999). "Albinism and agenesis of the corpus callosum with profound developmental delay: Vici syndrome, evidence for autosomal ... 1999) "Albinism and agenesis of the corpus callosum with profound developmental delay: Vici syndrome, evidence for autosomal ... 1988). "Agenesis of the corpus callosum, combined immunodeficiency, bilateral cataract, and hypopigmentation in two brothers". ... hypopigmentation and absent corpus callosum (or absent corpus callosum cataract immunodeficiency), is a rare autosomal ...
https://en.wikipedia.org/wiki/Vici_syndrome
Chudley-Mccullough syndromeChudley-Mccullough syndrome
... partial agenesis of the corpus callosum, and arachnoid cysts in two sisters". American Journal of Medical Genetics. 86 (2): 183 ... agenesis of the corpus callosum, and other structural brain abnormalities". American Journal of Medical Genetics. Part A. 124A ... partial corpus callosum agenesis, and hydrocephalus. Their parents weren't consanguineous, however; they did come from the same ... corpus callosum partial agenesis, and cerebellar cell migration anomalies. 2004: Elsebet Østergaard et al. describes two ...
https://en.wikipedia.org/wiki/Chudley-Mccullough_syndrome
Optic nerve hypoplasiaOptic nerve hypoplasia
Besides having small optic nerves, persons with ONH can have agenesis of the corpus callosum, absence of the septum pellucidum ... Abnormalities evident via neuroradiography can include agenesis (absence) or hypoplasia of the corpus callosum, absence or ... Predictors of significantly delayed development include hypoplasia or agenesis of the corpus callosum and hypothyroidism. The ... Hypoplasia of the corpus callosum, often in conjunction with other major malformations, is significantly associated with poor ...
https://en.wikipedia.org/wiki/Optic_nerve_hypoplasia
Anterior commissureAnterior commissure
One such study supported colour perception in callosal agenesis (Those born without a corpus callosum; Barr & Corballis, 2002 ... The corpus callosum allows for communication between the two hemispheres and is found only in placental mammals (the eutherians ... In most existing mammals, the great majority of fibers connecting the two hemispheres travel through the corpus callosum, which ... Anterior commissure Posterior commissure Corpus callosum This article incorporates text in the public domain from page 840 of ...
https://en.wikipedia.org/wiki/Anterior_commissure
Aicardi syndromeAicardi syndrome
Partial or complete absence of the corpus callosum in the brain (agenesis of the corpus callosum); Eye abnormalities known as " ... syndrome characterized by the partial or complete absence of a key structure in the brain called the corpus callosum, the ... Aicardi J, Lefebvre J, Lerique-Koechlin A. A new syndrome: spasm in flexion, callosal agenesis, ocular abnormalities. ... Corpus callosum, Syndromes with tumors, Rare syndromes). ...
https://en.wikipedia.org/wiki/Aicardi_syndrome
L1 (protein)L1 (protein)
This includes disorders such as HSAS, MASA syndrome, agenesis of the corpus callosum and spastic paraplegia. Lower limb ... Fransen E, Lemmon V, Van Camp G, Vits L, Coucke P, Willems PJ (1996). "CRASH syndrome: clinical spectrum of corpus callosum ... Mutations in the L1 protein are the cause of L1 syndrome, sometimes known by the acronym CRASH (corpus callosum hypoplasia, ...
https://en.wikipedia.org/wiki/L1_(protein)
Strømme syndromeStrømme syndrome
Agenesis or hypoplasia of the corpus callosum and cerebellum have been found in at least one living affected individual and ... sometimes together with agenesis of the corpus callosum. Physical features are variable but usually include short stature, ...
https://en.wikipedia.org/wiki/Strømme_syndrome
List of diseases (C)List of diseases (C)
... malformation Coronary artery aneurysm Coronary heart disease Coronavirus disease 2019 Corpus callosum agenesis Corpus callosum ... Calciphylaxis Calculi Calderon-Gonzalez-Cantu syndrome Calloso genital dysplasia Callus disease Calpainopathy Calvarial ... degeneration Cerebellar parenchymal degeneration Cerebelloolivary atrophy Cerebelloparenchymal disorder 3 Cerebellum agenesis ... Centrotemporal epilepsy Cephalopolysyndactyly Ceramidase deficiency Ceramide trihexosidosis Ceraunophobia Cerebellar agenesis ...
https://en.wikipedia.org/wiki/List_of_diseases_(C)
ZTTK syndromeZTTK syndrome
... hypoplasia of the corpus callosum and cerebellar hemispheres and loss of periventricular white matter. Most individuals with ... dysplastic kidney and agenesis of the lung and gallbladder have also been noted. Whole body musculoskeletal abnormalities have ...
https://en.wikipedia.org/wiki/ZTTK_syndrome
NFIANFIA
... and agenesis of the corpus callosum". Proceedings of the National Academy of Sciences of the United States of America. 96 (21 ...
https://en.wikipedia.org/wiki/NFIA
Pallister-Killian syndromePallister-Killian syndrome
These defects include: brain atrophy, agenesis of the corpus callosum, polymicrogyria of the brain, and/or spot calcifications ...
https://en.wikipedia.org/wiki/Pallister–Killian_syndrome
Shapiro syndromeShapiro syndrome
2008 Jun;66(2B):418-9. PMID 18641886 "Subtotal corpus callosum agenesis with recurrent hyperhidrosis-hypothermia (Shapiro ... and agenesis of the corpus callosum with onset typically on adulthood. The disease affects about 50 people worldwide. The ...
https://en.wikipedia.org/wiki/Shapiro_syndrome
Commissural fiberCommissural fiber
A recent study of individuals with agenesis of the corpus callosum suggests that the corpus callosum plays a vital role in ... Aging Age-related decline in the commissural fiber tracts that make up the corpus callosum indicate the corpus callosum is ... The corpus callosum is the largest commissural tract in the human brain. It consists of about 200-300 million axons that ... The corpus callosum allows for communication between the two hemispheres and is found only in placental mammals. The anterior ...
https://en.wikipedia.org/wiki/Commissural_fiber
Fetal alcohol spectrum disorderFetal alcohol spectrum disorder
FAS has also been linked to brainstem and cerebellar changes, agenesis of the corpus callosum and anterior commissure, neuronal ... agenesis of the corpus callosum, cerebellar hypoplasia). Microcephaly is determined by comparing head circumference (often ... The autopsy showed severe hydrocephalus, abnormal neuronal migration, and a small corpus callosum (which connects the two brain ... Zimmerberg B, Mickus LA (December 1990). "Sex differences in corpus callosum: influence of prenatal alcohol exposure and ...
https://en.wikipedia.org/wiki/Fetal_alcohol_spectrum_disorder
List of fetal abnormalitiesList of fetal abnormalities
Acardiac twin Achondrogenesis Achondroplasia Adrenal hematoma Agenesis of the corpus callosum Amniotic band syndrome Anal ... Omphalocele Osteogenesis imperfecta Pentalogy of Cantrell Polydactyly Polyhydramnios Posterior urethral valves Renal agenesis ...
https://en.wikipedia.org/wiki/List_of_fetal_abnormalities
Disconnection syndromeDisconnection syndrome
... of cerebral commissures to treat epilepsy and callosal agenesis which is when individuals are born without a corpus callosum. ... Callosal syndrome, or split-brain, is an example of a disconnection syndrome from damage to the corpus callosum between the two ... He described the callosal syndrome, an example of a disconnection syndrome, which is a lesion in the corpus callosum that leads ... Dejerine in 1892 described specific symptoms resulting from a lesion to the corpus callosum that caused alexia without agraphia ...
https://en.wikipedia.org/wiki/Disconnection_syndrome
Toriello-Carey syndromeToriello-Carey syndrome
... syndrome is a genetic disorder that is characterized by Pierre Robin sequence and agenesis of the corpus callosum. Children ... Neurological abnormalities include defects of the corpus callosum, hypotonia, and hearing loss. The etiology of the disorder is ...
https://en.wikipedia.org/wiki/Toriello–Carey_syndrome
Neuronal migration disorderNeuronal migration disorder
Polymicrogyria Agyria Macrogyria Microgyria Micropolygyria Grey matter heterotopia Agenesis of the corpus callosum Agenesis of ...
https://en.wikipedia.org/wiki/Neuronal_migration_disorder
List of diseases (M)List of diseases (M)
Michelin tire baby syndrome Michels Caskey syndrome Michels syndrome Mickleson syndrome Micrencephaly corpus callosum agenesis ... cardiomyopathy Measles Meckel like syndrome Meckel syndrome Medeira Dennis Donnai syndrome Median cleft lip corpus callosum ... Müllerian agenesis) MSBD syndrome MTHFR deficiency Mucha-Habermann disease Muckle-Wells syndrome Mucoepithelial dysplasia ... Mucormycosis Mucosulfatidosis Muenke syndrome Mulibrey nanism Müller-Barth-Menger syndrome Müllerian agenesis Müllerian aplasia ...
https://en.wikipedia.org/wiki/List_of_diseases_(M)
Linda Richards (neuroscientist)Linda Richards (neuroscientist)
In particular, she is involved in researching a phenomenon where the corpus callosum is absent (agenesis) or disformed ( ... "The Corpus Collosum". "Professor Linda Richards AO". Australian Disorders of the Corpus Callosum.{{cite web}}: CS1 maint: url- ... Richards also acts as scientific advisor for the Australian Disorders of the Corpus Callosum. 2010 Nina Kondelos Prize for " ... "Balanced interhemispheric cortical activity is required for correct targeting of the corpus callosum". Neuron. 82 (6): 1289-98 ...
https://en.wikipedia.org/wiki/Linda_Richards_(neuroscientist)
PachygyriaPachygyria
... and agenesis or malformation of the corpus callosum. Classical lissencephaly can range from agyria to regional pachygyria and ... types are associated with corpus callosum agenesis or cerebellar hypoplasia while the cobblestone lissencephalies are ... corpus callosum aplasia, and decreased muscle tone and tendon reflexes. Over 90% of children affected with lissencephaly have ...
https://en.wikipedia.org/wiki/Pachygyria
Smith-Lemli-Opitz syndromeSmith-Lemli-Opitz syndrome
... hard palate cleft lip/palate agenesis or hypoplasia of the corpus callosum cerebellar hypoplasia increased ventricular size ...
https://en.wikipedia.org/wiki/Smith–Lemli–Opitz_syndrome
Stanislas LyonnetStanislas Lyonnet
Homozygous silencing of T-box transcription factor EOMES leads to microcephaly with polymicrogyria and corpus callosum agenesis ...
https://en.wikipedia.org/wiki/Stanislas_Lyonnet
Small supernumerary marker chromosomeSmall supernumerary marker chromosome
... agenesis of the corpus callosum (lack of the thick tract of nerve fibers that connect the left and right cerebral hemispheres ...
https://en.wikipedia.org/wiki/Small_supernumerary_marker_chromosome
1p36 deletion syndrome1p36 deletion syndrome
Common structural brain abnormalities include agenesis of the corpus callosum, cerebral cortical atrophy, gait abnormalities, ...
https://en.wikipedia.org/wiki/1p36_deletion_syndrome
HypoplasiaHypoplasia
... in Agenesis of the corpus callosum Cerebellum caused by mutation in the Reelin gene Tooth caused by oral pathology, such as ... trisomy X Thymus in DiGeorge syndrome Labia majora in popliteal pterygium syndrome Corpus callosum, connecting the two sides of ... left heart syndrome and hypoplastic right heart syndrome Optic nerve in optic nerve hypoplasia Sacrum in sacral agenesis Facial ...
https://en.wikipedia.org/wiki/Hypoplasia
University of California, San Francisco Fetal Treatment CenterUniversity of California, San Francisco Fetal Treatment Center
The Fetal Treatment Center specializes in the diagnosis and treatment of fetal birth defects: Agenesis of the corpus callosum ...
https://en.wikipedia.org/wiki/University_of_California,_San_Francisco_Fetal_Treatment_Center
Primrose syndromePrimrose syndrome
Additionally, she was born with Ebstein malformation, a congenital heart defect, agenesis of the corpus callosum, and hip ...
https://en.wikipedia.org/wiki/Primrose_syndrome
COX7BCOX7B
... agenesis of the corpus callosum, and other central nervous system abnormalities. The COX7B mutations associated with disease ...
https://en.wikipedia.org/wiki/COX7B
Corpus callosum agenesis | Radiology Case | Radiopaedia.orgCorpus callosum agenesis | Radiology Case | Radiopaedia.org
Corpus callosum agenesis was an incidental finding in this case. Widely spaced ventricles are due vertically oriented white ... Q: Which part of the corpus callosum appears last? show answer A: Rostrum. Visualisation of rostrum rules out primary agenesis ... Corpus callosum agenesis was an incidental finding in this case. Widely spaced ventricles are due vertically oriented white ... Agenesis of the corpus callosum: magnetic resonance imaging. Radiology. 1985;155 (2): 371-3. Radiology (abstract) - Pubmed ...
https://radiopaedia.org/cases/corpus-callosum-agenesis-1?lang=us
RePub, Erasmus University Repository: Agenesis of the corpus callosum associated with paroxysmal hypothermia: Shapiros...RePub, Erasmus University Repository: Agenesis of the corpus callosum associated with paroxysmal hypothermia: Shapiro's...
Agenesis of the corpus callosum associated with paroxysmal hypothermia: Shapiros syndrome. Publication. Publication. The ... Segeren, C.M, Polderman, K.H, & Lips, P. (1997). Agenesis of the corpus callosum associated with paroxysmal hypothermia: ...
https://repub.eur.nl/pub/64377
Agenesis of the corpus callosum is associated with developmental delay and intellectu . . . by Quinton J. Mandle"Agenesis of the corpus callosum is associated with developmental delay and intellectu . . ." by Quinton J. Mandle
Clinical characterization, genetics, and long-term follow-up of a large cohort of patients with agenesis of the corpus callosum ... Agenesis of the corpus callosum is associated with developmental delay and intellectual disability. Clin. Res. Prac. 2019 Sep 5 ... Clinical characterization, genetics, and long-term follow-up of a large cohort of patients with agenesis of the corpus callosum ... Agenesis of the corpus callosum is associated with developmental delay and intellectual disability ...
https://digitalcommons.wayne.edu/crp/vol5/iss2/3/
IMSEAR at SEARO: Agenesis of the corpus callosum. Report of a case.
Karunakaran EK, Gupta S. Agenesis of the corpus callosum. Report of a case. Indian Journal of Pediatrics. 1969 Sep; 36(260): ...
https://imsear.searo.who.int/handle/123456789/80166?locale=en
Agenesis of Corpus Callosum-MRI - Sumers Radiology BlogAgenesis of Corpus Callosum-MRI - Sumer's Radiology Blog
Agenesis of Corpus Callosum-MRI Reviewed by Sumer Sethi on Tuesday, May 28, 2013 Rating: 5 ... Home corpus callosum agenesis Neuroradiology Agenesis of Corpus Callosum-MRI Agenesis of Corpus Callosum-MRI ... I have a blog about living with AgCC called A Boy with a Whole in His Head~a day in the life of a man without a corpus ... I was born with full Agenesis of the CC. All my life have had developmental issues, but only disovered this 5 years ago, it ...
https://www.indianradiology.com/2013/05/agenesis-of-corpus-callosum-mri.html
Agenesis of the Corpus Callosum - Fetal Health FoundationAgenesis of the Corpus Callosum - Fetal Health Foundation
Agenesis of the corpus callosum diagnosis? We have resources to help.. Parents who have received a fetal diagnosis need support ... Medically-reviewed agenesis of the corpus callosum information will be posted soon. Please search our treatment center database ...
https://www.fetalhealthfoundation.org/fetal-syndromes/agenesis-of-the-corpus-callosum/
Agenesis of the corpus callosum - Raw Milk and Honey
Agenesis of the Corpus Callosum and Colpocephaly Posted on June 24, 2014. by Jen Posted in Agenesis of the corpus callosum, ... Agenesis of the corpus callosum Sinking In Posted on July 2, 2014. by Jen Posted in Agenesis of the corpus callosum, Pregnancy ... My son is missing his corpus callosum entirely. The technical name is complete agenesis of the corpus callosum. The CC connects ... Tags: 30 weeks, agenesis of corpus callosum, pregnancy, prenatal diagnosis . ...
https://rawmilkandhoney.com/category/agenesis-of-the-corpus-callosum/
Natural cure for Corpus Callosum Agenesis and alternative treatments
Get natural cures for Corpus Callosum Agenesis that can make a difference in your life or the life of someone you love with ... Corpus Callosum Agenesis by state. Corpus Callosum Agenesis in Alabama. Corpus Callosum Agenesis in Alaska. Corpus Callosum ... Corpus Callosum Agenesis in Iowa. Corpus Callosum Agenesis in Kansas. Corpus Callosum Agenesis in Kentucky. Corpus Callosum ... Corpus Callosum Agenesis in Florida. Corpus Callosum Agenesis in Georgia. Corpus Callosum Agenesis in Hawaii. Corpus Callosum ...
http://www.naturalcurefor.com/treatments/corpus-callosum-agenesis
Aicardi syndrome: MedlinePlus GeneticsAicardi syndrome: MedlinePlus Genetics
Agenesis of corpus callosum with chorioretinal abnormality. *Agenesis of corpus callosum with infantile spasms and ocular ... agenesis or dysgenesis of the corpus callosum. ). They have seizures beginning in infancy (infantile spasms), which tend to ...
https://medlineplus.gov/genetics/condition/aicardi-syndrome
Partial agenesis of corpus callosum in Sanjad-Sakati syndrome (p-ACC) - PDF Free DownloadPartial agenesis of corpus callosum in Sanjad-Sakati syndrome (p-ACC) - PDF Free Download
Partial agenesis of corpus callosum in Sanjad-Sakati syndrome (p-ACC). 330 Abstracts perfused under anesthesia, and the choroid ... Partial agenesis of corpus callosum in Sanjad-Sakati syndrome (p-ACC) N. ALGhasaba, B. Janatib, A. Khanc, aQassim University, ... The brain MRI in our patient showed a partial agenesis of the corpus callosum (p-ACC) characterized by the absence of the ... Partial agenesis of corpus callosum in Sanjad-Sakati syndrome (p-ACC) *HOME ...
https://coek.info/pdf-partial-agenesis-of-corpus-callosum-in-sanjadsakati-syndrome-p-acc-.html
A female child with corpus callosum agenesis and infantile spasm<...
Al-Futaisi A, Al-Azri F, Ganesh A, Al-Mukhaini K, Koul RL, Heera M. A female child with corpus callosum agenesis and infantile ... Al-Futaisi, A, Al-Azri, F, Ganesh, A, Al-Mukhaini, K, Koul, RL & Heera, M 2008, A female child with corpus callosum agenesis ... A female child with corpus callosum agenesis and infantile spasm. Amna Al-Futaisi*, Faisal Al-Azri, Anuradha Ganesh, Khoolod Al ... A female child with corpus callosum agenesis and infantile spasm. / Al-Futaisi, Amna; Al-Azri, Faisal; Ganesh, Anuradha et al. ...
https://squ.pure.elsevier.com/en/publications/a-female-child-with-corpus-callosum-agenesis-and-infantile-spasm
Basal Cell Carcinoma Clinical Presentation: History, Physical ExaminationBasal Cell Carcinoma Clinical Presentation: History, Physical Examination
Congenital agenesis of the corpus callosum and medulloblastoma * Odontogenic jaw cysts * Bifid ribs and pectus excavatum ...
https://www.medscape.com/answers/276624-100148/what-are-the-types-of-basal-cell-carcinoma-bcc
Table 1 - Zika Virus-Associated Birth Defects, Costa Rica, 2016-2018 - Volume 27, Number 2-February 2021 - Emerging Infectious...
Partial agenesis of the corpus callosum. 1. Cleft palate. 1. Diseases, maternal conditions, or problems at delivery, n = 27. ...
https://wwwnc.cdc.gov/eid/article/27/2/20-2047-t1
The Science Behind 23andMe - Our Science & Testing ProcessThe Science Behind 23andMe - Our Science & Testing Process
Agenesis of the Corpus Callosum with Peripheral Neuropathy and our test ACCPN is a rare genetic disorder. It is characterized ... Agenesis of the Corpus Callosum with Peripheral Neuropathy Autosomal Recessive Polycystic Kidney Disease Beta Thalassemia and ...
https://www.23andme.com/genetic-science/
Homfray T[au] - Search Results - PubMedHomfray T[au] - Search Results - PubMed
Counseling in fetal medicine: agenesis of the corpus callosum. Santo S, DAntonio F, Homfray T, Rich P, Pilu G, Bhide A, ...
https://pubmed.ncbi.nlm.nih.gov/?cmd=search&term=Homfray+T%5Bau%5D&dispmax=50
Love That Max : A look at the Upsee mobility device for kids-and your chance to win oneLove That Max : A look at the Upsee mobility device for kids-and your chance to win one
My son, Zac, is 8. He has Cerebral palsy and agenesis of the corpus callosum. He loves to be mobile, though he cant walk. the ...
https://www.lovethatmax.com/2014/04/upsee-mobility-device.html?showComment=1396888329523&m=1
Aicardi Syndrome Clinical Presentation: History, Physical, CausesAicardi Syndrome Clinical Presentation: History, Physical, Causes
... total or partial agenesis of the corpus callosum, and variable ocular abnormalities. This clinical scenario, already reported ... Agenesis of the Corpus Callosum and Aicardi Syndrome: A Neuroimaging and Clinical Comparison. Pediatr Neurol. 2017 Mar. 68:44-8 ... A study by Govil-Dalela et al indicated that compared with children who have nonsyndromic agenesis of the corpus callosum, ... Novel presentation of Aicardi syndrome with agenesis of the corpus callosum and an orbital cyst. J Ultrasound Med. 2010 May. 29 ...
https://emedicine.medscape.com/article/941426-clinical
Frontiers | Possible functional links among brain- and skull-related genes selected in modern humansFrontiers | Possible functional links among brain- and skull-related genes selected in modern humans
... and agenesis of the corpus callosum (Proud et al., 1992) which are features of interest in the context of this paper. ... and agenesis of the corpus callosum. Am. J. Med. Genet. 43, 458-466. doi: 10.1002/ajmg.1320430169 ... Theofanopoulou, C. (2015). Corpus Callosum and Language: a Bottom-up Approach with Evolutionary Epilegomena. Barcelona: ... 2014). Gli3 controls corpus callosum formation by positioning midline guideposts during telencephalic patterning. Cereb. Cortex ...
https://www.frontiersin.org/articles/10.3389/fpsyg.2015.00794/full
Audiologic Issues in CHARGE SyndromeAudiologic Issues in CHARGE Syndrome
Radiographic studies have shown instances of dysgenesis or agenesis of the corpus callosum. In cases with relatively normal ...
https://www.asha.org/articles/audiologic-issues-in-charge-syndrome/
The Eye Institute of Utah, Salt Lake City, UTThe Eye Institute of Utah, Salt Lake City, UT
Iris Coloboma - Macrocephaly - Agenesis of the Corpus Callosum - Brachydactyly - Mental Retardation. *. Juvenile Macular ...
https://www.healthgrades.com/group-directory/ut-utah/salt-lake-city/the-eye-institute-of-utah-xx67kf0c
Conditions - VarietyConditions - Variety
Agenesis of the Corpus Callosum. *Aicardi Syndrome. *Alopecia. *Amputation. *Andermann Syndrome. *Angelman Syndrome ...
https://www.variety.org.au/sa/how-we-help/conditions/
A Japanese Patient with Genitopatellar Syndrome Transiently Presenting with Cardiac Intramural Cavity during the Neonatal PeriodA Japanese Patient with Genitopatellar Syndrome Transiently Presenting with Cardiac Intramural Cavity during the Neonatal Period
... corpus callosum agenesis with microcephaly, and hydronephrosis and/or multiple renal cysts. More than half of patients with GPS ... It is characterized by genital abnormalities, patellar hypoplasia/agenesis, flexion contractures of the hips and knees, ... patellar hypoplasia/agenesis, flexion contractures of the hips and knees, corpus callosum agenesis with microcephaly, and ... d) A sagittal fluid-attenuated inversion recovery (FLAIR) image showing corpus callosum agenesis. (e) Sagittal T2-weighted MRI ...
https://www.hindawi.com/journals/crig/2020/1731720/
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Partial Agenesis (Hypoplasia) of the Corpus Callosum Premature Closing of the Fontanel ...
https://chromodisorder.org/registration/
What to Do About Your Brain Injured Child? - IAHPWhat to Do About Your Brain Injured Child? - IAHP
Initial assessment revealed a Partial Agenesis of Corpus Callosum. At the age of 10 months, Jaden was diagnosed with Global ... After a lot of different tests and MRI scans, Wei Xuan was diagnosed with Hypogenesis of the Corpus Callosum, which means that ...
https://iahp.org/hurt-children/what-to-do-about-your-brain-injured-child/
Welcome to PhenoDisWelcome to PhenoDis
Agenesis of corpus callosum. 142 / 7739 52. (OMIM) Prominent umbilical stump. 1 / 7739 ...
http://mips.helmholtz-muenchen.de/phenodis/disease/show/883
coloboma - Ontology Report - Rat Genome Databasecoloboma - Ontology Report - Rat Genome Database
ClinVar Annotator: match by term: Corpus callosum agenesis-intellectual disability-coloboma-micrognathia syndrome. OMIM. ... COI; agenesis of macula; coloboma of eye; coloboma of iris, choroid, and retina; colobomas; congenital ocular coloboma; ocular ... corpus callosum agenesis-intellectual disability-coloboma-micrognathia syndrome Symbol. Object Name. Evidence. Notes. Source. ...
https://rgd.mcw.edu/rgdweb/ontology/annot.html?species=Rat&acc_id=DOID:12270
Elliott Sherr, MD, PhD | Biomedical Sciences Graduate Program
Major brain malformations: corpus callosum dysgenesis, agenesis of septum pellucidum and polymicrogyria in patients with BCORL1 ... specifically focusing on patients with agenesis of the corpus callosum (ACC). ACC has a strong association with autism, as ...
https://bms.ucsf.edu/people/elliott-sherr-md-phd
BCORL1 BCL6 corepressor like 1 [Homo sapiens (human)] - Gene - NCBIBCORL1 BCL6 corepressor like 1 [Homo sapiens (human)] - Gene - NCBI
Major brain malformations: corpus callosum dysgenesis, agenesis of septum pellucidum and polymicrogyria in patients with BCORL1 ... Major brain malformations: corpus callosum dysgenesis, agenesis of septum pellucidum and polymicrogyria in patients with BCORL1 ... Title: Major brain malformations: corpus callosum dysgenesis, agenesis of septum pellucidum and polymicrogyria in patients with ...
https://www.ncbi.nlm.nih.gov/gene/63035
MedlinePlus - Search Results for: cataracts
Absent corpus callosum cataract immunodeficiency Corpus callosum agenesis-cataract-immunodeficiency syndrome Dionisi ... ...
https://vsearch.nlm.nih.gov/vivisimo/cgi-bin/query-meta?&v:project=medlineplus&v:sources=medlineplus-bundle&query=cataracts&binning-state=group%3D%3DGenetics&
AbnormalitiesDysgenesis of the corpusHypoplasiaDisorders of the Corpus CallosumAicardi SyndromeBrainMalformationsSeptum pellucidumAbsenceFetalBilateralCerebralColpocephalyDiagnosisUltrasoundOpticClinicalMagneticDevelopmentalRostrumIncludeCompleteChildrenRoleCaseConditionIndividuals
Abnormalities8
  • Our patient showed partial agenesis of the corpus callosum which could explain the patient's motor, behavioral and developmental abnormalities (reference). (coek.info)
  • A study by Govil-Dalela et al indicated that compared with children who have nonsyndromic agenesis of the corpus callosum, those in whom the agenesis is related to Aicardi syndrome suffer earlier onset of seizures and worse developmental outcomes, with neuroimaging revealing larger areas of brain abnormalities in these patients. (medscape.com)
  • It is characterized by genital abnormalities, patellar hypoplasia/agenesis, flexion contractures of the hips and knees, corpus callosum agenesis with microcephaly, and hydronephrosis and/or multiple renal cysts. (hindawi.com)
  • [1] It may present as an isolated anomaly or be associated with midline cerebral structural defect, such as septum pellucidum absence, agenesis of corpus callosum, cerebral hemisphere abnormalities, or pituitary gland abnormalities. (aao.org)
  • Some affected individuals have brain abnormalities, such as absent or underdeveloped tissue connecting the left and right halves of the brain (agenesis or dysgenesis of the corpus callosum ). (medlineplus.gov)
  • Polymicrogyria can co-occur with other structural abnormalities, including abnormalities of the white matter, corpus callosum, cerebellum and basal ganglia. (epilepsydiagnosis.org)
  • Abnormalities seen on brain imaging include hemi-megalencephaly, migrational abnormalities, agenesis of the corpus callosum, asymmetrical or symmetrical ventricular dilatation, focal cerebral atrophy with porencephalic ventricular dilatation, hemiatrophy, diffuse cerebral atrophy, cerebellar hypoplasia or atrophy, vascular abnormalities, and rarely tumors [ 4 ]. (cdlib.org)
  • Typical characteristics of ACLS are hypoplasia/agenesis of corpus callosum, moderate to severe mental retardation, characteristic craniofacial abnormalities, distinctive digital malformations and growth retardation. (who.int)
Dysgenesis of the corpus2
  • People with Aicardi syndrome have absent or underdeveloped tissue connecting the left and right halves of the brain (agenesis or dysgenesis of the corpus callosum ). (medlineplus.gov)
  • Agenesis and dysgenesis of the corpus callosum: clinical, genetic and neuroimaging findings in a series of 41 patients. (mpg.de)
Hypoplasia4
  • Other anomalies commonly reported with congenital ZIKV infection can be seen with congenital CMV but less so compared with other congenital infections, including cortical atrophy, corpus callosal agenesis/hypoplasia, cerebellar (or cerebellar vermis) hypoplasia, neuronal migration defects such as gyral anomalies or heterotopia, periventricular calcifications, hydrocephalus ex vacuo, glaucoma, and postnatal-onset microcephaly. (cdc.gov)
  • Dr. Hoyt attributed the discovery of the association of optic nerve hypoplasia with septum pellucidum agenesis to de Morsier, and resurrected the term septo-optic dysplasia syndrome. (aao.org)
  • Hypoplasia of the cerebellar vermis and corpus callosum has been reported in this syndrome. (medscape.com)
  • Severe brain malformations such as lissencephaly, cerebellar hypoplasia, and dysgenesis/agenesis of the corpus callosum are frequently present. (arizona.edu)
Disorders of the Corpus Callosum4
  • My lawyer husband insists that I point out that the views expressed by the presenters are their own, and do not necessarily represent the views of the National Organization for Disorders of the Corpus Callosum, with whom we are collaborating. (pdf-archive.com)
  • This story is part of the Adults with DCC series that showcases the abilities and lives of real adults living with disorders of the corpus callosum. (nodcc.org)
  • The National Organization for Disorders of the Corpus Callosum (NODCC) is a 501(c)(3) nonprofit established in 2003 for individuals with disorders of the corpus callosum, their families and professionals. (nodcc.org)
  • The NODCC has become the leading organization for disorders of the corpus callosum seeking to raise the profile, understanding and acceptance of these disorders through education, networking, advocacy, and being a catalyst for research. (nodcc.org)
Aicardi Syndrome1
  • Anomalies of the sulci and gyri, periventricular heterotopia, associated cerebellar and brain stem anomalies with absent corpus callosum, can also be evaluated with magnetic resonance imaging (MRI) to aid in the diagnosis and to better determine the prognosis in Aicardi syndrome. (medscape.com)
Brain11
  • An effective method for diagnosing Corpus callosum agenesis is through brain scan. (naturalcurefor.com)
  • Corpus callosum agenesis results from development disruption of the 'fetal brain' during its fifth and sixth week of conception. (naturalcurefor.com)
  • The brain MRI in our patient showed a partial agenesis of the corpus callosum (p-ACC) characterized by the absence of the splenium and rostrum of this structure. (coek.info)
  • Major brain malformations: corpus callosum dysgenesis, agenesis of septum pellucidum and polymicrogyria in patients with BCORL1-related disorders. (ucsf.edu)
  • MYERS, RONALD E.;SPERRY, R. W. 1958-09-01 00:00:00 Abstract The early brain anatomists assumed highly important functions for the corpus callosum in relating and coordinating the activities of the two cerebral hemispheres. (deepdyve.com)
  • However, actual observations on the effect of complete surgical section or of total agenesis of the corpus callosum in man and other animals have indicated a surprising absence of deficit.1-6,8,9 This wide discrepancy between the expected and the actual effects of callosal damage has remained one of the enigmas of brain function. (deepdyve.com)
  • Bruce, A.: On the Absence of the Corpus Callosum in the Human Brain with Description of a New Case , Brain 12:171, 1890.Crossref 5. (deepdyve.com)
  • 13. Myers, R. E.: Function of Corpus Callosum in Interocular Transfer , Brain 79:358, 1956. (deepdyve.com)
  • One of the people I cared for was missing the entire Corpus Calossum of the brain, which is not only a profound anatomical difference, but a structural one. (madinamerica.com)
  • This research describes the impact of Agenesis of the Corpus Callosum (AgCC) on working memory and general neurobehavioural functioning, and its impact on the functional brain organisation of working memory processes using a specially designed fMRI Brown-Peterson task. (unige.ch)
  • He went on to tell me the results of her MRI - she was missing the corpus callosum of her brain (the part of the brain that connects the right and left hemispheres). (truveta.com)
Malformations1
  • 9. Kirschbaum, W. R.: Agenesis of Corpus Callosum and Associated Malformations , J. Neuropath. (deepdyve.com)
Septum pellucidum2
  • Septo-optic dysplasia (SOD, de Morsier syndrome) is used to describe the association between ONH and the absence of septum pellucidum, deficiency of pituitary hormones and agenesis of corpus callosum. (aao.org)
  • In 1941, Dr. David Reeves at Children's Hospital Los Angeles first described the association of ONH with agenesis of the septum pellucidum. (aao.org)
Absence4
  • Most often, the absence of the corpus callosum on the fetal ultrasonogram prompts further imaging studies. (medscape.com)
  • A rare genetic disorder characterized by partial or complete absence of the CORPUS CALLOSUM , resulting in infantile spasms, MENTAL RETARDATION , and lesions of the RETINA or OPTIC NERVE . (nih.gov)
  • Birth defect that results in a partial or complete absence of the CORPUS CALLOSUM . (bvsalud.org)
  • Acrocallosal syndrome (ACLS), also known by its synonyms: Schinzel Acrocallosal syndrome and Hallux duplication, Postaxial polydactyly and absence of corpus callosum, is a rare genetic disorder that is apparent at birth. (who.int)
Fetal2
  • Counseling in fetal medicine: agenesis of the corpus callosum. (nih.gov)
  • Whole-Exome Sequencing Revealed Mutations of MED12 and EFNB1 in Fetal Agenesis of the Corpus Callosum. (bvsalud.org)
Bilateral3
  • Ultrasonography and magnetic resonance imaging confirmed corpus callosum agenesis, cerebral ventricle dilation, bilateral moderate hydronephrosis, and bilateral missing patellar cartilage (Figures 1(d) - 1(f) ). (hindawi.com)
  • Bridgman, C. S., and Smith, K. U.: Bilateral Neural Integration in Visual Perception After Section of the Corpus Callosum , J. Comp. (deepdyve.com)
  • A small number of individuals with cutaneous hypopigmentation, combined immunodeficiency, agenesis of the corpus callosum, bilateral cataracts, and cleft lip and palate have been described. (medscape.com)
Cerebral1
  • Our lab has shown that de novo and inherited genetic events play an important role in causing disorders of cerebral development, specifically focusing on patients with agenesis of the corpus callosum (ACC). (ucsf.edu)
Colpocephaly2
  • Where VM is a general term for enlarged ventricles, colpocephaly is a specific type of dilation - in this case the occipital horns of the lateral ventricles are enlarged to "fill in the space" left by the missing corpus callosum. (rawmilkandhoney.com)
  • blind (due to congenital eye anomalies) and has congenital anomalies syndrome mainly affecting the facial area, agenesis of the corpus callosum, colpocephaly and delayed motor development. (reecesrainbow.org)
Diagnosis1
Ultrasound1
  • His cranial ultrasound was reported to show partial agenesis of the corpus callosum. (bmj.com)
Optic1
  • Stamm, J. S., and Miner, N.: Relearning Tests for Interocular Transfer Following Division of Optic Chiasma and Corpus Callosum in Cats , J. Comp. (deepdyve.com)
Clinical2
  • Clinical characterization, genetics, and long-term follow-up of a large cohort of patients with agenesis of the corpus callosum. (wayne.edu)
  • Cameron, J. L.: The Corpus Callosum: A Morphological and Clinical Study , Canad. (deepdyve.com)
Magnetic1
  • Agenesis of the corpus callosum: magnetic resonance imaging. (radiopaedia.org)
Developmental1
  • I was born with full Agenesis of the CC. All my life have had developmental issues, but only disovered this 5 years ago, it changed my life. (indianradiology.com)
Rostrum1
Include1
  • An avid researcher, Dr. Delello's professional interests include, among other things, response to intervention (RTI) and intervention strategies for children with agenesis of the corpus callosum. (pdf-archive.com)
Complete1
  • A CT scan showed Jennifer had complete agenesis of the corpus callosum (ACC). (nodcc.org)
Children1
  • One of her children has agenesis of the corpus callosum and a Dandy-Walker Malformation. (pdf-archive.com)
Role2
  • Recent investigations of contralateral transfer of training in callosum-intact and callosum-sectioned animals, however, begin to reveal a definite role for the corpus callosum in the realm of 'psychic' function. (deepdyve.com)
  • The question of whether there is a right-hemisphere dominance in the processing of auditory spatial information in human cortex as well as the role of the corpus callosum in spatial hearing functions is still a matter of debate. (researchgate.net)
Case1
  • Corpus callosum agenesis was an incidental finding in this case. (radiopaedia.org)
Condition1
  • The condition is called Agenesis of the Corpus Callosum (ACC). (truveta.com)
Individuals1
  • Our mission is to enhance the quality of life and promote opportunities for individuals with disorders for the corpus callosum. (nodcc.org)
Aicardi syndrome: MedlinePlus Genetics
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Brain Malformations | MedlinePlus
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Aicardi syndrome: MedlinePlus Medical Encyclopedia
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RePub, Erasmus University Repository: Agenesis of the corpus callosum associated with paroxysmal hypothermia: Shapiro's...
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SLC12A6 gene: MedlinePlus Genetics
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Conditions - Variety
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Registration - Chromosome Disorder Outreach, Inc
Registration - Chromosome Disorder Outreach, Inc (chromodisorder.org)
What to Do About Your Brain Injured Child? - IAHP
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Agenesis of the Corpus Callosum | National Institute of Neurological Disorders and Stroke
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