Age of onset. Medical search

Elements of limited time intervals, contributing to particular results or situations.

The beginning of true OBSTETRIC LABOR which is characterized by the cyclic uterine contractions of increasing frequency, duration, and strength causing CERVICAL DILATATION to begin (LABOR STAGE, FIRST ).

Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.

An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.

The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.

The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.

Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.

Recording of electric currents developed in the brain by means of electrodes applied to the scalp, to the surface of the brain, or placed within the substance of the brain.

Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.

Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.

Disease having a short and relatively severe course.

Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.

Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.

Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.

Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.

Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.

The time from the onset of a stimulus until a response is observed.

A subtype of DIABETES MELLITUS that is characterized by INSULIN deficiency. It is manifested by the sudden onset of severe HYPERGLYCEMIA, rapid progression to DIABETIC KETOACIDOSIS, and DEATH unless treated with insulin. The disease may occur at any age, but is most common in childhood or adolescence.

The record of descent or ancestry, particularly of a particular condition or trait, indicating individual family members, their relationships, and their status with respect to the trait or condition.

The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.

A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.

Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.

Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.

Achievement of full sexual capacity in animals and in humans.

A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)

Recording of the changes in electric potential of muscle by means of surface or needle electrodes.

Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.

Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or "seizure disorder."

The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS.

A latent susceptibility to disease at the genetic level, which may be activated under certain conditions.

The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.

Studies in which variables relating to an individual or group of individuals are assessed over a period of time.

Maleness or femaleness as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or effect of a circumstance. It is used with human or animal concepts but should be differentiated from SEX CHARACTERISTICS, anatomical or physiological manifestations of sex, and from SEX DISTRIBUTION, the number of males and females in given circumstances.

Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.

A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.

The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases, new or old, in the population at a given time.

A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)

In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.

An infant during the first month after birth.

A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.

Divisions of the year according to some regularly recurrent phenomena usually astronomical or climatic. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)

Investigative technique commonly used during ELECTROENCEPHALOGRAPHY in which a series of bright light flashes or visual patterns are used to elicit brain activity.

A characteristic symptom complex.

Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.

NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).

The regular recurrence, in cycles of about 24 hours, of biological processes or activities, such as sensitivity to drugs and stimuli, hormone secretion, sleeping, and feeding.

Tomography using x-ray transmission and a computer algorithm to reconstruct the image.

Abrupt changes in the membrane potential that sweep along the CELL MEMBRANE of excitable cells in response to excitation stimuli.

Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.

A subtype of striated muscle, attached by TENDONS to the SKELETON. Skeletal muscles are innervated and their movement can be consciously controlled. They are also called voluntary muscles.

Antibodies that react with self-antigens (AUTOANTIGENS) of the organism that produced them.

The relationship between the dose of an administered drug and the response of the organism to the drug.

A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)

RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.

Use of sound to elicit a response in the nervous system.

Conditions characterized by recurrent paroxysmal neuronal discharges which arise from a focal region of the brain. Partial seizures are divided into simple and complex, depending on whether consciousness is unaltered (simple partial seizure) or disturbed (complex partial seizure). Both types may feature a wide variety of motor, sensory, and autonomic symptoms. Partial seizures may be classified by associated clinical features or anatomic location of the seizure focus. A secondary generalized seizure refers to a partial seizure that spreads to involve the brain diffusely. (From Adams et al., Principles of Neurology, 6th ed, pp317)

The repetitive uterine contraction during childbirth which is associated with the progressive dilation of the uterine cervix (CERVIX UTERI). Successful labor results in the expulsion of the FETUS and PLACENTA. Obstetric labor can be spontaneous or induced (LABOR, INDUCED).

Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.

Bleeding into one or both CEREBRAL HEMISPHERES including the BASAL GANGLIA and the CEREBRAL CORTEX. It is often associated with HYPERTENSION and CRANIOCEREBRAL TRAUMA.

Use of electric potential or currents to elicit biological responses.

A generalized seizure disorder characterized by recurrent major motor seizures. The initial brief tonic phase is marked by trunk flexion followed by diffuse extension of the trunk and extremities. The clonic phase features rhythmic flexor contractions of the trunk and limbs, pupillary dilation, elevations of blood pressure and pulse, urinary incontinence, and tongue biting. This is followed by a profound state of depressed consciousness (post-ictal state) which gradually improves over minutes to hours. The disorder may be cryptogenic, familial, or symptomatic (caused by an identified disease process). (From Adams et al., Principles of Neurology, 6th ed, p329)

Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.

Use of infusions of FIBRINOLYTIC AGENTS to destroy or dissolve thrombi in blood vessels or bypass grafts.

The return of a sign, symptom, or disease after a remission.

Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action during the developmental stages of an organism.

Variant forms of the same gene, occupying the same locus on homologous CHROMOSOMES, and governing the variants in production of the same gene product.

Histochemical localization of immunoreactive substances using labeled antibodies as reagents.

Recording of the moment-to-moment electromotive forces of the HEART as projected onto various sites on the body's surface, delineated as a scalar function of time. The recording is monitored by a tracing on slow moving chart paper or by observing it on a cardioscope, which is a CATHODE RAY TUBE DISPLAY.

Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.

The health status of the family as a unit including the impact of the health of one member of the family on the family as a unit and on individual family members; also, the impact of family organization or disorganization on the health status of its members.

A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)

The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.

A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94)

The act, process, or result of passing from one place or position to another. It differs from LOCOMOTION in that locomotion is restricted to the passing of the whole body from one place to another, while movement encompasses both locomotion but also a change of the position of the whole body or any of its parts. Movement may be used with reference to humans, vertebrate and invertebrate animals, and microorganisms. Differentiate also from MOTOR ACTIVITY, movement associated with behavior.

The rate dynamics in chemical or physical systems.

Behavioral manifestations of cerebral dominance in which there is preferential use and superior functioning of either the left or the right side, as in the preferred use of the right hand or right foot.

The total number of cases of a given disease in a specified population at a designated time. It is differentiated from INCIDENCE, which refers to the number of new cases in the population at a given time.

Refers to animals in the period of time just after birth.

The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.

The phase of cell nucleus division following METAPHASE, in which the CHROMATIDS separate and migrate to opposite poles of the spindle.

Methods to determine in patients the nature of a disease or disorder at its early stage of progression. Generally, early diagnosis improves PROGNOSIS and TREATMENT OUTCOME.

Disorders in which there is a loss of ego boundaries or a gross impairment in reality testing with delusions or prominent hallucinations. (From DSM-IV, 1994)

Biochemical identification of mutational changes in a nucleotide sequence.

A class of statistical methods applicable to a large set of probability distributions used to test for correlation, location, independence, etc. In most nonparametric statistical tests, the original scores or observations are replaced by another variable containing less information. An important class of nonparametric tests employs the ordinal properties of the data. Another class of tests uses information about whether an observation is above or below some fixed value such as the median, and a third class is based on the frequency of the occurrence of runs in the data. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1284; Corsini, Concise Encyclopedia of Psychology, 1987, p764-5)

A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.

A state in which there is an enhanced potential for sensitivity and an efficient responsiveness to external stimuli.

An individual having different alleles at one or more loci regarding a specific character.

Neurons which activate MUSCLE CELLS.

The period in the ESTROUS CYCLE associated with maximum sexual receptivity and fertility in non-primate female mammals.

Incoordination of voluntary movements that occur as a manifestation of CEREBELLAR DISEASES. Characteristic features include a tendency for limb movements to overshoot or undershoot a target (dysmetria), a tremor that occurs during attempted movements (intention TREMOR), impaired force and rhythm of diadochokinesis (rapidly alternating movements), and GAIT ATAXIA. (From Adams et al., Principles of Neurology, 6th ed, p90)

Electrical responses recorded from nerve, muscle, SENSORY RECEPTOR, or area of the CENTRAL NERVOUS SYSTEM following stimulation. They range from less than a microvolt to several microvolts. The evoked potential can be auditory (EVOKED POTENTIALS, AUDITORY), somatosensory (EVOKED POTENTIALS, SOMATOSENSORY), visual (EVOKED POTENTIALS, VISUAL), or motor (EVOKED POTENTIALS, MOTOR), or other modalities that have been reported.

Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.

A proteolytic enzyme in the serine protease family found in many tissues which converts PLASMINOGEN to FIBRINOLYSIN. It has fibrin-binding activity and is immunologically different from UROKINASE-TYPE PLASMINOGEN ACTIVATOR. The primary sequence, composed of 527 amino acids, is identical in both the naturally occurring and synthetic proteases.

A cylindrical column of tissue that lies within the vertebral canal. It is composed of WHITE MATTER and GRAY MATTER.

Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care. (Dictionary of Health Services Management, 2d ed)

A severe emotional disorder of psychotic depth characteristically marked by a retreat from reality with delusion formation, HALLUCINATIONS, emotional disharmony, and regressive behavior.

The number of times the HEART VENTRICLES contract per unit of time, usually per minute.

Fibrinolysin or agents that convert plasminogen to FIBRINOLYSIN.

The thin layer of GRAY MATTER on the surface of the CEREBRAL HEMISPHERES that develops from the TELENCEPHALON and folds into gyri and sulchi. It reaches its highest development in humans and is responsible for intellectual faculties and higher mental functions.

Imaging techniques used to colocalize sites of brain functions or physiological activity with brain structures.

Assessment of sensory and motor responses and reflexes that is used to determine impairment of the nervous system.

The study of the generation and behavior of electrical charges in living organisms particularly the nervous system and the effects of electricity on living organisms.

The domestic cat, Felis catus, of the carnivore family FELIDAE, comprising over 30 different breeds. The domestic cat is descended primarily from the wild cat of Africa and extreme southwestern Asia. Though probably present in towns in Palestine as long ago as 7000 years, actual domestication occurred in Egypt about 4000 years ago. (From Walker's Mammals of the World, 6th ed, p801)

The presence of co-existing or additional diseases with reference to an initial diagnosis or with reference to the index condition that is the subject of study. Comorbidity may affect the ability of affected individuals to function and also their survival; it may be used as a prognostic indicator for length of hospital stay, cost factors, and outcome or survival.

Statistical models which describe the relationship between a qualitative dependent variable (that is, one which can take only certain discrete values, such as the presence or absence of a disease) and an independent variable. A common application is in epidemiology for estimating an individual's risk (probability of a disease) as a function of a given risk factor.

A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.

The physical activity of a human or an animal as a behavioral phenomenon.

A type of CELL NUCLEUS division by means of which the two daughter nuclei normally receive identical complements of the number of CHROMOSOMES of the somatic cells of the species.

A localization-related (focal) form of epilepsy characterized by recurrent seizures that arise from foci within the temporal lobe, most commonly from its mesial aspect. A wide variety of psychic phenomena may be associated, including illusions, hallucinations, dyscognitive states, and affective experiences. The majority of complex partial seizures (see EPILEPSY, COMPLEX PARTIAL) originate from the temporal lobes. Temporal lobe seizures may be classified by etiology as cryptogenic, familial, or symptomatic (i.e., related to an identified disease process or lesion). (From Adams et al., Principles of Neurology, 6th ed, p321)

Periods of sleep manifested by changes in EEG activity and certain behavioral correlates; includes Stage 1: sleep onset, drowsy sleep; Stage 2: light sleep; Stages 3 and 4: delta sleep, light sleep, deep sleep, telencephalic sleep.

Drugs that interrupt transmission at the skeletal neuromuscular junction without causing depolarization of the motor end plate. They prevent acetylcholine from triggering muscle contraction and are used as muscle relaxants during electroshock treatments, in convulsive states, and as anesthesia adjuvants.

Decrease in the size of a cell, tissue, organ, or multiple organs, associated with a variety of pathological conditions such as abnormal cellular changes, ischemia, malnutrition, or hormonal changes.

A spectrum of pathological conditions of impaired blood flow in the brain. They can involve vessels (ARTERIES or VEINS) in the CEREBRUM, the CEREBELLUM, and the BRAIN STEM. Major categories include INTRACRANIAL ARTERIOVENOUS MALFORMATIONS; BRAIN ISCHEMIA; CEREBRAL HEMORRHAGE; and others.

Procedures for finding the mathematical function which best describes the relationship between a dependent variable and one or more independent variables. In linear regression (see LINEAR MODELS) the relationship is constrained to be a straight line and LEAST-SQUARES ANALYSIS is used to determine the best fit. In logistic regression (see LOGISTIC MODELS) the dependent variable is qualitative rather than continuously variable and LIKELIHOOD FUNCTIONS are used to find the best relationship. In multiple regression, the dependent variable is considered to depend on more than a single independent variable.

In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.

A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.

Standardized procedures utilizing rating scales or interview schedules carried out by health personnel for evaluating the degree of mental illness.

Predetermined sets of questions used to collect data - clinical data, social status, occupational group, etc. The term is often applied to a self-completed survey instrument.

Drugs used to prevent SEIZURES or reduce their severity.

Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.

The tendency of a phenomenon to recur at regular intervals; in biological systems, the recurrence of certain activities (including hormonal, cellular, neural) may be annual, seasonal, monthly, daily, or more frequently (ultradian).

Tests designed to assess neurological function associated with certain behaviors. They are used in diagnosing brain dysfunction or damage and central nervous system disorders or injury.

A distribution in which a variable is distributed like the sum of the squares of any given independent random variable, each of which has a normal distribution with mean of zero and variance of one. The chi-square test is a statistical test based on comparison of a test statistic to a chi-square distribution. The oldest of these tests are used to detect whether two or more population distributions differ from one another.

Surgically placed electric conductors through which ELECTRIC STIMULATION is delivered to or electrical activity is recorded from a specific point inside the body.

The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.

A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.

An abrupt voluntary shift in ocular fixation from one point to another, as occurs in reading.

An individual in which both alleles at a given locus are identical.

The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)

Impairment of the ability to perform smoothly coordinated voluntary movements. This condition may affect the limbs, trunk, eyes, pharynx, larynx, and other structures. Ataxia may result from impaired sensory or motor function. Sensory ataxia may result from posterior column injury or PERIPHERAL NERVE DISEASES. Motor ataxia may be associated with CEREBELLAR DISEASES; CEREBRAL CORTEX diseases; THALAMIC DISEASES; BASAL GANGLIA DISEASES; injury to the RED NUCLEUS; and other conditions.

Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)

The electric response evoked in the CEREBRAL CORTEX by ACOUSTIC STIMULATION or stimulation of the AUDITORY PATHWAYS.

The range or frequency distribution of a measurement in a population (of organisms, organs or things) that has not been selected for the presence of disease or abnormality.

Disorders characterized by impairment of the ability to initiate or maintain sleep. This may occur as a primary disorder or in association with another medical or psychiatric condition.

A return to earlier, especially to infantile, patterns of thought or behavior, or stage of functioning, e.g., feelings of helplessness and dependency in a patient with a serious physical illness. (From APA, Thesaurus of Psychological Index Terms, 1994).

The coordination of a sensory or ideational (cognitive) process and a motor activity.

Genes that influence the PHENOTYPE both in the homozygous and the heterozygous state.

One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.

Arthritis of children, with onset before 16 years of age. The terms juvenile rheumatoid arthritis (JRA) and juvenile idiopathic arthritis (JIA) refer to classification systems for chronic arthritis in children. Only one subtype of juvenile arthritis (polyarticular-onset, rheumatoid factor-positive) clinically resembles adult rheumatoid arthritis and is considered its childhood equivalent.

The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.

Development of SEXUAL MATURATION in boys and girls at a chronological age that is 2.5 standard deviations below the mean age at onset of PUBERTY in the population. This early maturation of the hypothalamic-pituitary-gonadal axis results in sexual precocity, elevated serum levels of GONADOTROPINS and GONADAL STEROID HORMONES such as ESTRADIOL and TESTOSTERONE.

The electric response evoked in the cerebral cortex by visual stimulation or stimulation of the visual pathways.

Disorders that are characterized by the production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides.

A spontaneous diminution or abatement of a disease over time, without formal treatment.

Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.

A biogenic amine that is found in animals and plants. In mammals, melatonin is produced by the PINEAL GLAND. Its secretion increases in darkness and decreases during exposure to light. Melatonin is implicated in the regulation of SLEEP, mood, and REPRODUCTION. Melatonin is also an effective antioxidant.

ARTHRITIS that is induced in experimental animals. Immunological methods and infectious agents can be used to develop experimental arthritis models. These methods include injections of stimulators of the immune response, such as an adjuvant (ADJUVANTS, IMMUNOLOGIC) or COLLAGEN.

A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.

Proteins found in the nucleus of a cell. Do not confuse with NUCLEOPROTEINS which are proteins conjugated with nucleic acids, that are not necessarily present in the nucleus.

The process whereby auditory stimuli are selected, organized, and interpreted by the organism.

Studies in which the presence or absence of disease or other health-related variables are determined in each member of the study population or in a representative sample at one particular time. This contrasts with LONGITUDINAL STUDIES which are followed over a period of time.

A species of the genus MACACA inhabiting India, China, and other parts of Asia. The species is used extensively in biomedical research and adapts very well to living with humans.

The ratio of two odds. The exposure-odds ratio for case control data is the ratio of the odds in favor of exposure among cases to the odds in favor of exposure among noncases. The disease-odds ratio for a cohort or cross section is the ratio of the odds in favor of disease among the exposed to the odds in favor of disease among the unexposed. The prevalence-odds ratio refers to an odds ratio derived cross-sectionally from studies of prevalent cases.

Sudden increase in the incidence of a disease. The concept includes EPIDEMICS and PANDEMICS.

A major gonadotropin secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Luteinizing hormone regulates steroid production by the interstitial cells of the TESTIS and the OVARY. The preovulatory LUTEINIZING HORMONE surge in females induces OVULATION, and subsequent LUTEINIZATION of the follicle. LUTEINIZING HORMONE consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is common in the three pituitary glycoprotein hormones (TSH, LH and FSH), but the beta subunit is unique and confers its biological specificity.

The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)

The lack of development of SEXUAL MATURATION in boys and girls at a chronological age that is 2.5 standard deviations above the mean age at onset of PUBERTY in a population. Delayed puberty can be classified by defects in the hypothalamic LHRH pulse generator, the PITUITARY GLAND, or the GONADS. These patients will undergo spontaneous but delayed puberty whereas patients with SEXUAL INFANTILISM will not.

Systemic-onset rheumatoid arthritis in adults. It differs from classical rheumatoid arthritis in that it is more often marked by acute febrile onset, and generalized lymphadenopathy and hepatosplenomegaly are more prominent.

The regular and simultaneous occurrence in a single interbreeding population of two or more discontinuous genotypes. The concept includes differences in genotypes ranging in size from a single nucleotide site (POLYMORPHISM, SINGLE NUCLEOTIDE) to large nucleotide sequences visible at a chromosomal level.

A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.

The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.

The co-inheritance of two or more non-allelic GENES due to their being located more or less closely on the same CHROMOSOME.

Established cell cultures that have the potential to propagate indefinitely.

Also known as articulations, these are points of connection between the ends of certain separate bones, or where the borders of other bones are juxtaposed.

A set of techniques used when variation in several variables has to be studied simultaneously. In statistics, multivariate analysis is interpreted as any analytic method that allows simultaneous study of two or more dependent variables.

Androstanes and androstane derivatives which are substituted in any position with one or more hydroxyl groups.

Those occurrences, including social, psychological, and environmental, which require an adjustment or effect a change in an individual's pattern of living.

The probability that an event will occur. It encompasses a variety of measures of the probability of a generally unfavorable outcome.

The selecting and organizing of visual stimuli based on the individual's past experience.

Any of the ruminant mammals with curved horns in the genus Ovis, family Bovidae. They possess lachrymal grooves and interdigital glands, which are absent in GOATS.

Categorical classification of MENTAL DISORDERS based on criteria sets with defining features. It is produced by the American Psychiatric Association. (DSM-IV, page xxii)

Marked depression appearing in the involution period and characterized by hallucinations, delusions, paranoia, and agitation.

The observable response an animal makes to any situation.

A technique that localizes specific nucleic acid sequences within intact chromosomes, eukaryotic cells, or bacterial cells through the use of specific nucleic acid-labeled probes.

Focusing on certain aspects of current experience to the exclusion of others. It is the act of heeding or taking notice or concentrating.

A single nucleotide variation in a genetic sequence that occurs at appreciable frequency in the population.

A technique of inputting two-dimensional images into a computer and then enhancing or analyzing the imagery into a form that is more useful to the human observer.

Recording of the average amplitude of the resting potential arising between the cornea and the retina in light and dark adaptation as the eyes turn a standard distance to the right and the left. The increase in potential with light adaptation is used to evaluate the condition of the retinal pigment epithelium.

Proteins that control the CELL DIVISION CYCLE. This family of proteins includes a wide variety of classes, including CYCLIN-DEPENDENT KINASES, mitogen-activated kinases, CYCLINS, and PHOSPHOPROTEIN PHOSPHATASES as well as their putative substrates such as chromatin-associated proteins, CYTOSKELETAL PROTEINS, and TRANSCRIPTION FACTORS.

Simultaneous and continuous monitoring of several parameters during sleep to study normal and abnormal sleep. The study includes monitoring of brain waves, to assess sleep stages, and other physiological variables such as breathing, eye movements, and blood oxygen levels which exhibit a disrupted pattern with sleep disturbances.

Disturbances in mental processes related to learning, thinking, reasoning, and judgment.

The major progestational steroid that is secreted primarily by the CORPUS LUTEUM and the PLACENTA. Progesterone acts on the UTERUS, the MAMMARY GLANDS and the BRAIN. It is required in EMBRYO IMPLANTATION; PREGNANCY maintenance, and the development of mammary tissue for MILK production. Progesterone, converted from PREGNENOLONE, also serves as an intermediate in the biosynthesis of GONADAL STEROID HORMONES and adrenal CORTICOSTEROIDS.

An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.

A social group consisting of parents or parent substitutes and children.

That portion of the electromagnetic spectrum in the visible, ultraviolet, and infrared range.

Signals for an action; that specific portion of a perceptual field or pattern of stimuli to which a subject has learned to respond.

A transferase that catalyzes formation of PHOSPHOCREATINE from ATP + CREATINE. The reaction stores ATP energy as phosphocreatine. Three cytoplasmic ISOENZYMES have been identified in human tissues: the MM type from SKELETAL MUSCLE, the MB type from myocardial tissue and the BB type from nervous tissue as well as a mitochondrial isoenzyme. Macro-creatine kinase refers to creatine kinase complexed with other serum proteins.

Microsatellite repeats consisting of three nucleotides dispersed in the euchromatic arms of chromosomes.

The intentional interruption of transmission at the NEUROMUSCULAR JUNCTION by external agents, usually neuromuscular blocking agents. It is distinguished from NERVE BLOCK in which nerve conduction (NEURAL CONDUCTION) is interrupted rather than neuromuscular transmission. Neuromuscular blockade is commonly used to produce MUSCLE RELAXATION as an adjunct to anesthesia during surgery and other medical procedures. It is also often used as an experimental manipulation in basic research. It is not strictly speaking anesthesia but is grouped here with anesthetic techniques. The failure of neuromuscular transmission as a result of pathological processes is not included here.

Computer-assisted processing of electric, ultrasonic, or electronic signals to interpret function and activity.

The measure of the level of heat of a human or animal.

The proportion of one particular in the total of all ALLELES for one genetic locus in a breeding POPULATION.

The measurement of magnetic fields over the head generated by electric currents in the brain. As in any electrical conductor, electric fields in the brain are accompanied by orthogonal magnetic fields. The measurement of these fields provides information about the localization of brain activity which is complementary to that provided by ELECTROENCEPHALOGRAPHY. Magnetoencephalography may be used alone or together with electroencephalography, for measurement of spontaneous or evoked activity, and for research or clinical purposes.

A heterogenous group of degenerative syndromes marked by progressive cerebellar dysfunction either in isolation or combined with other neurologic manifestations. Sporadic and inherited subtypes occur. Inheritance patterns include autosomal dominant, autosomal recessive, and X-linked.

The non-genetic biological changes of an organism in response to challenges in its ENVIRONMENT.

A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.

The region of the cerebral cortex that receives the auditory radiation from the MEDIAL GENICULATE BODY.

Cardiovascular disease in insulin dependent diabetes mellitus: similar rates but different risk factors in the US compared with Europe. (1/5966)

BACKGROUND: Cardiovascular disease (CVD) in insulin dependent diabetes mellitus (IDDM) has been linked to renal disease. However, little is known concerning international variation in the correlations with hyperglycaemia and standard CVD risk factors. METHODS: A cross-sectional comparison was made of prevalence rates and risk factor associations in two large studies of IDDM subjects: the Pittsburgh Epidemiology of Diabetes Complications Study (EDC) and the EURODIAB IDDM Complications Study from 31 centres in Europe. Subgroups of each were chosen to be comparable by age and duration of diabetes. The EDC population comprises 286 men (mean duration 20.1 years) and 281 women (mean duration 19.9 years); EURODIAB 608 men (mean duration 18.1 years) and 607 women (mean duration 18.9 years). The mean age of both populations was 28 years. Cardiovascular disease was defined by a past medical history of myocardial infarction, angina, and/or the Minnesota ECG codes (1.1-1.3, 4.1-4.3, 5.1-5.3, 7.1). RESULTS: Overall prevalence of CVD was similar in the two populations (i.e. men 8.6% versus 8.0%, women 7.4% versus 8.5%, EURODIAB versus EDC respectively), although EDC women had a higher prevalence of angina (3.9% versus 0.5%, P < 0.001). Multivariate modelling suggests that glycaemic control (HbA1c) is not related to CVD in men. Age and high density lipoprotein cholesterol predict CVD in EURODIAB, while triglycerides and hypertension predict CVD in EDC. For women in both populations, age and hypertension (or renal disease) are independent predictors. HbA1c is also an independent predictor-inversely in EURODIAB women (P < 0.008) and positively in EDC women (P = 0.03). Renal disease was more strongly linked to CVD in EDC than in EURODIAB. CONCLUSIONS: Despite a similar prevalence of CVD, risk factor associations appear to differ in the two study populations. Glycaemic control (HbA1c) does not show a consistent or strong relationship to CVD. (+info)

Hereditary juvenile haemochromatosis: a genetically heterogeneous life-threatening iron-storage disease. (2/5966)

Juvenile haemochromatosis is a rare inborn error of iron metabolism with clinical manifestations before 30 years of age. Unlike adult haemochromatosis which principally affects men, juvenile haemochromatosis affects the sexes equally; it causes early endocrine failure, dilated cardiomyopathy and joint disease. We report four patients (two of each sex) from three pedigrees affected by juvenile haemochromatosis with a mean onset at 22 years (range 14-30). All had endocrine deficiency with postpubertal gonadal failure secondary to pituitary disease; two suffered near-fatal cardiomyopathy with heart failure. Mean time to diagnosis from the first clinical signs of disease was 9.8 years (range 0.5-20) but general health and parameters of iron storage responded favourably to iron-depletion therapy. A 24-year-old man listed for heart transplantation because of cardiomyopathy [left ventricular (LV) ejection fraction 16%] responded to intravenous iron chelation with desferrioxamine combined with phlebotomy (ejection fraction 31%). A 27-year-old woman with subacute biventricular heart failure refractory to medication required orthotopic cardiac transplantation before the diagnosis was established (LV ejection fraction 25%). Genetic studies showed that these two patients with cardiomyopathy from unrelated families were heterozygous for the HFE 845G-->A (C282Y) mutation and wild-type at the H63D locus: complete sequencing of the intron-exon boundaries and entire coding sequence of the HFE gene failed to identify additional lesions. Two siblings in a pedigree without cardiomyopathy were wild-type at the HFE C282Y locus; although the brother harboured a single copy of the 187C-->G (H63D) allele, segregation analysis showed that in neither sibling was the iron-storage disease linked to MHC Class I markers on chromosome 6p. Juvenile haemochromatosis is thus a genetically heterogenous disorder distinct from the common adult variant. (+info)

Constitutional genetic variation at the human aromatase gene (Cyp19) and breast cancer risk. (3/5966)

The activity of the aromatase enzyme, which converts androgens into oestrogens and has a major role in regulating oestrogen levels in the breast, is thought to be a contributing factor in the development of breast cancer. We undertook this study to assess the role of constitutional genetic variation in the human aromatase gene (Cyp19) in the development of this disease. Our genotyping of 348 cases with breast cancer and 145 controls (all Caucasian women) for a published tetranucleotide repeat polymorphism at intron 4 of the Cyp19 gene revealed the presence of six common and two rare alleles. Contingency table analysis revealed a significant difference in allelic distribution between cases and controls (chi2 5df = 13.52, P = 0.019). The allele measuring 171 bp was over-represented in cases; of 14 individuals homozygous for this allele, 13 were cases. These individuals had a higher incidence of cancer in family members and an earlier age at diagnosis than other cases. In sequencing Cyp19's coding exons and regulatory regions, we discovered a perfect association between a silent polymorphism (G-->A at Val80) and the high-risk genotype. Our conclusion is that constitutional genetic variation at the Cyp19 locus is associated with the risk of developing breast cancer, with the 171-bp allele serving as the high-risk allele. (+info)

Cancer risk in close relatives of women with early-onset breast cancer--a population-based incidence study. (4/5966)

Inherited susceptibility to breast cancer is associated with an early onset and bilateral disease. The extent of familial risks has not, however, been fully assessed in population-based incidence studies. The purpose of the study was to quantify the risks for cancers of the breast, ovary and other sites of close relatives of women in whom breast cancer was diagnosed at an early age. Records collected between 1943 and 1990 at the Danish Cancer Registry were searched, and 2860 women were found in whom breast cancer was diagnosed before age 40. Population registers and parish records were used to identify 14 973 parents, siblings and offspring of these women. Cancer occurrence through to 31 December 1993 was determined within the Cancer Registry's files and compared with national incidence rates. Women with early-onset breast cancer were at a nearly fourfold increased risk of developing a new cancer later in life (268 observed vs. 68.9 expected). The excess risk was most evident for second cancer of the breast (181 vs. 24.5) and for ovarian cancer (20 vs. 3.3). For mothers and sisters, risks for cancers of the breast and ovary were significantly increased by two- to threefold. Bilateral breast cancer and breast-ovarian cancer were very strong predictors of familial risks, with one in four female relatives predicted to develop breast and/or ovarian cancer by age 75. Mothers had a slightly increased risk of colon cancer, but not endometrial cancer. The risk for breast cancer was also increased among fathers (standardized incidence ratio 2.5; 95% CI 0.5-7.4) and especially brothers (29; 7.7-74), although based on small numbers. The risk for prostatic cancer was unremarkable. In this large population-based survey, the first-degree relatives of women who developed breast cancer before age 40 were prone to ovarian cancer as well as male and female breast cancer, but not other tumours that may share susceptibility genes with breast cancer. (+info)

Age of onset in Huntington disease: sex specific influence of apolipoprotein E genotype and normal CAG repeat length. (5/5966)

Age of onset (AO) of Huntington disease (HD) is known to be correlated with the length of an expanded CAG repeat in the HD gene. Apolipoprotein E (APOE) genotype, in turn, is known to influence AO in Alzheimer disease, rendering the APOE gene a likely candidate to affect AO in other neurological diseases too. We therefore determined APOE genotype and normal CAG repeat length in the HD gene for 138 HD patients who were previously analysed with respect to CAG repeat length. Genotyping for APOE was performed blind to clinical information. In addition to highlighting the effect of the normal repeat length upon AO in maternally inherited HD and in male patients, we show that the APOE epsilon2epsilon3 genotype is associated with significantly earlier AO in males than in females. Such a sex difference in AO was not apparent for any of the other APOE genotypes. Our findings suggest that subtle differences in the course of the neurodegeneration in HD may allow interacting genes to exert gender specific effects upon AO. (+info)

Multipoint oligogenic analysis of age-at-onset data with applications to Alzheimer disease pedigrees. (6/5966)

It is usually difficult to localize genes that cause diseases with late ages at onset. These diseases frequently exhibit complex modes of inheritance, and only recent generations are available to be genotyped and phenotyped. In this situation, multipoint analysis using traditional exact linkage analysis methods, with many markers and full pedigree information, is a computationally intractable problem. Fortunately, Monte Carlo Markov chain sampling provides a tool to address this issue. By treating age at onset as a right-censored quantitative trait, we expand the methods used by Heath (1997) and illustrate them using an Alzheimer disease (AD) data set. This approach estimates the number, sizes, allele frequencies, and positions of quantitative trait loci (QTLs). In this simultaneous multipoint linkage and segregation analysis method, the QTLs are assumed to be diallelic and to interact additively. In the AD data set, we were able to localize correctly, quickly, and accurately two known genes, despite the existence of substantial genetic heterogeneity, thus demonstrating the great promise of these methods for the dissection of late-onset oligogenic diseases. (+info)

Analysis of affected sib pairs, with covariates--with and without constraints. (7/5966)

Covariate models have previously been developed as an extension to affected-sib-pair methods in which the covariate effects are jointly estimated with the degree of excess allele sharing. These models can estimate the differences in sib-pair allele sharing that are associated with measurable environment or genes. When there are no covariates, the pattern of identical-by-descent allele sharing in affected sib pairs is expected to fall within a small triangular region of the potential parameter space, under most genetic models. By restriction of the estimated allele sharing to this triangle, improved power is obtained in tests for genetic linkage. When the affected-sib-pair model is generalized to allow for covariates that affect allele sharing, however, new constraints and new methods for the application of constraints are required. Three generalized constraint methods are proposed and evaluated by use of simulated data. The results compare the power of the different methods, with and without covariates, for a single-gene model with age-dependent onset and for quantitative and qualitative gene-environment and gene-gene interaction models. Covariates can improve the power to detect linkage and can be particularly valuable when there are qualitative gene-environment interactions. In most situations, the best strategy is to assume that there is no dominance variance and to obtain constrained estimates for covariate models under this assumption. (+info)

Identification of a C/G polymorphism in the promoter region of the BRCA1 gene and its use as a marker for rapid detection of promoter deletions. (8/5966)

Reduced expression of BRCA1 has been implicated in sporadic breast cancer, although the mechanisms underlying this phenomenon remain unclear. To determine whether regulatory mutations could account for the reduced expression, we screened the promoter region by sequencing in 20 patients with sporadic disease. No mutations were detected; however, a new polymorphism consisting of a C-to-G base change within the beta-promoter was identified, with the frequency of the G allele being 0.34. Close to complete linkage disequilibrium was found between this marker and the Pro871 Leu polymorphism, situated in exon 11, which has previously been shown not to be associated with breast or ovarian cancer. This indicates that the C/G polymorphism is also unlikely to play a role in either disease. However, the strength of linkage disequilibrium between these markers permitted their use for rapid screening for genomic deletions within BRCA1. A series of 214 cases with familial breast cancer were analysed using this approach; 88/214 were heterozygous for the promoter polymorphism, thereby excluding a deletion in this region. Among the remaining patients, one hemizygous case reflecting a promoter deletion was successfully identified. Therefore, this study indicates that deletions within the beta-promoter region of BRCA1 are an uncommon event in familial breast cancer. Furthermore, it suggests that mutations within the BRCA1 promoter are unlikely to account for the reported decreased expression of BRCA1 in sporadic disease. (+info)

... the age of onset may be the result of mutation accumulation. If this is the case, it could be helpful to consider ages of onset ... The age of onset is the age at which an individual acquires, develops, or first experiences a condition or symptoms of a ... Sipilä, Jussi O. T.; Kauko, Tommi; Päivärinta, Markku; Majamaa, Kari (2017-08-28). "Comparison of mid-age-onset and late-onset ... The rate-of-living theory may not be used to draw conclusions about age of onset based on this. There are two subsets to the ...

https://en.wikipedia.org/wiki/Age_of_onset

Age of onset (or onset age) is a term that is used in criminology in reference to the age at which the offense of a crime is ... doi:10.1111/j.1745-9125.2000.tb01417.x. Look up Age of onset in Wiktionary, the free dictionary. v t e (Juvenile delinquency, ... Mazerolle, P.; Brame, R.; Paternoster, R.; Piquero, A.; Dean, C (2000). "Onset age, persistence, and offending versatility: ... Bacon, Sarah; Paternoster, Raymond; Brame, Robert (2008-08-20). "Understanding the Relationship Between Onset Age and ...

https://en.wikipedia.org/wiki/Age_of_onset_(criminology)

... , also called younger-onset Alzheimer's, is Alzheimer's disease diagnosed before the age of 65. ... These guarantee onset of early-onset familial Alzheimer disease and all occur in the region of the APP gene that encodes the Aβ ... Most cases of early-onset Alzheimer's share the same traits as the "late-onset" form and are not caused by known genetic ... EOAD strikes earlier in life, defined as before the age of 65 (usually between 30 and 60 years of age).[medical citation needed ...

https://en.wikipedia.org/wiki/Early-onset_Alzheimer's_disease

Non-transient neonatal diabetes, or apparent type 1 diabetes with onset before six months of age. Liver adenoma or ... such as degree of insulin deficiency or age of onset).[citation needed] The following characteristics suggest the possibility ... juvenile-onset and maturity-onset, which roughly corresponded to what we now call type 1 and type 2. MODY was originally ... Maturity-onset diabetes of the young (MODY) refers to any of several hereditary forms of diabetes mellitus caused by mutations ...

https://en.wikipedia.org/wiki/Maturity-onset_diabetes_of_the_young

The age of onset is almost always before 3 months of age. Many infants are born preterm (1/3 cases) and dysmature. The babies ... Neonatal-Onset Multisystem Inflammatory Disease Responsive to Interleukin-1{beta} Inhibition N Engl J Med 2006 355: 581-592. ( ... Neonatal-onset multisystem inflammatory disease is a rare genetic periodic fever syndrome which causes uncontrolled ...

https://en.wikipedia.org/wiki/Neonatal-onset_multisystem_inflammatory_disease

... is dementia in which symptoms first appear before the age of 65. The term favored until about 2000 was ... Early onset dementia may be caused by degenerative or vascular disease, or it may be due to other causes, such as alcohol- ... Early-onset Alzheimer's disease, vascular dementia and frontotemporal lobar degeneration are the most common forms of early ... Roman de Mettelinge T, Calders P, Cambier D (2021). "The Effects of Aerobic Exercise in Patients with Early-Onset Dementia: A ...

https://en.wikipedia.org/wiki/Early_onset_dementia

However, there is some evidence that the main difference between two conditions is the age of onset. Systemic JIA is ... Systemic-onset juvenile idiopathic arthritis (or the juvenile onset form of Still's disease) is a type of juvenile idiopathic ... "juvenile-onset Still's disease" to distinguish it from adult-onset Still's disease. ... Cimaz, R; Von, Scheven; Hofer, M (9 May 2012). "Systemic-onset juvenile idiopathic arthritis: the changing life of a rare ...

https://en.wikipedia.org/wiki/Systemic-onset_juvenile_idiopathic_arthritis

Clearance of senescent cells has been found to delay the onset of age-related disorders. Stem cells are undifferentiated or ... Telomere shortening is associated with aging, mortality and aging-related diseases. Normal aging is associated with telomere ... The hallmarks of aging are the types of biochemical changes that occur in all organisms that experience biological aging and ... The links between cell senescence and aging are several: The proportion of senescent cells increases with age. Senescent cells ...

https://en.wikipedia.org/wiki/Hallmarks_of_aging

Thus, annual ophthalmologic examinations are advised for patients below the age of 16, and every 2-3 years above 16. Treatments ... Ocular albinism late onset sensorineural deafness (OASD) is a rare, X-linked recessive disease characterized by intense visual ... "Albinism ocular late onset sensorineural deafness , Genetic and Rare Diseases Information Center (GARD) - an NCATS Program". ... One patient with deletions of both TBL1 gene and OA1 gene displayed OA1 phenotype as well as associated late-onset ...

https://en.wikipedia.org/wiki/Ocular_albinism_late_onset_sensorineural_deafness

It appears to be chronic and non-contagious, affecting mainly people of Asian descent aged around 50. Cases first started ... Adult-onset immunodeficiency syndrome is a provisional name for an immunodeficiency illness. The name is proposed in the first ... "Adult-Onset Immunodeficiency in Thailand and Taiwan". New England Journal of Medicine. 367 (8): 725-734. doi:10.1056/ ...

https://en.wikipedia.org/wiki/Adult-onset_immunodeficiency_syndrome

The age of onsets has two points of maximum at age 2 and around age 40. New findings propose that an earlier onset leads to a ... No differences in rate relating to gender were found, and average age at onset was 24 years. In the United States, Hereditary ... the patient's age at onset; the affected genes; and biochemical pathways involved.[citation needed] No specific treatment is ... HSP has been classified as early onset beginning in early childhood or later onset in adulthood. ...

https://en.wikipedia.org/wiki/Hereditary_spastic_paraplegia

Age of onset is variable. The term 'juvenile' in the title of juvenile polyposis syndrome refers to the histological type of ... These usually begin appearing before age 20, but the term juvenile refers to the type of polyp (i.e benign hamartoma, as ... the polyps rather than the age of onset. Affected individuals may present with rectal bleeding, abdominal pain, diarrhea or ... opposed to adenoma for example), not to the age of the affected person. While the majority of the polyps found in juvenile ...

https://en.wikipedia.org/wiki/Juvenile_polyposis_syndrome

Onset of the juvenile form presents between 2 and 12 years of age. Duration of this form is in most cases about 6 years. The ... The juvenile form of Alexander disease has an onset between the ages of 2 and 13 years. These children may have excessive ... With early onset, death usually occurs within 10 years from the onset of symptoms. Individuals with the infantile form usually ... Neonatal onset is also reported. Onset in adults is least frequent. In older patients, bulbar or pseudobulbar symptoms and ...

https://en.wikipedia.org/wiki/Alexander_disease

Onset of symptoms generally occurs later in life, near the age of 60. The prevalence of the disorder among the elderly is ... Hearing loss in paraphrenics is associated with early age of onset, long duration, and profound auditory loss. The term ... "Late-Onset Schizophrenia and Other Related Psychoses". www.acnp.org. Archived from the original on 2010-03-08. Retrieved 2009- ... Most of the traits recognized prior to the onset of paraphrenia in individuals can be grouped as either paranoid or schizoid. ...

https://en.wikipedia.org/wiki/Paraphrenia

Onset can be in childhood; however, in multiple studies the average age of onset was 45. Many studies showed that women are ...

https://en.wikipedia.org/wiki/Proctalgia_fugax

Age of onset is puberty. Progressive in number and size. Not malignant. Can be treated with CO2 lasers or by removal by a ... The following is a list of conditions and complications associated with NF-1, and, where available, age range of onset and ... NF-1 is an age specific disease; most signs of NF-1 are visible after birth (during infancy), but many symptoms of NF-1 occur ... Their exact identity remains a bit of a mystery since they disappear over time (usually, by age 16), and they are not typically ...

https://en.wikipedia.org/wiki/Neurofibromatosis_type_I

Onset of effects is rapid. A number of doses may be needed. Side effects may include slow heart rate and low oxygen levels. Its ... Prevention is generally done in babies born at a gestational age of less than 32 weeks. It is given by the endotracheal tube. ... Prevention is generally done in babies born less than 32 weeks gestational age. Tentative evidence supports use in drowning. ...

https://en.wikipedia.org/wiki/Pulmonary_surfactant_(medication)

The disease is more common in female dogs of young and middle age. It has a rapid onset. The lesions of GME exist mainly in the ... and German Shorthaired Pointers younger than two years of age. Many cases have fever, loss of appetite, and severe neck pain ...

https://en.wikipedia.org/wiki/Granulomatous_meningoencephalitis

For example, sevoflurane is pleasant to inhale and is rapid in onset and offset. It is also safe for all ages. However, it is ... In addition it is odorless or pleasant to inhale; safe for all ages and in pregnancy; not metabolised; rapid in onset and ... Xenon is odourless and rapid in onset, but is expensive and requires specialized equipment to administer and monitor. Nitrous ...

https://en.wikipedia.org/wiki/Inhalational_anesthetic

Inzelberg, R., Schechtman, E., & Paleacu, D. (2002). Onset age of Parkinson disease. American journal of medical genetics, 111( ... Drugs & Aging, 20(11), 847-855. Inzelberg, R., P. Nisipeanu, J. M. Rabey, E. Orlov, T. Catz, S. Kippervasser, E. Schechtman, ... 5. Shinar, D., Schechtman, E., & Compton, R. (2001). Self-reports of safe driving behaviors in relationship to sex, age, ... Shinar, D., Schechtman, E., & Compton, R. (2001). Self-reports of safe driving behaviors in relationship to sex, age, education ...

https://en.wikipedia.org/wiki/Edna_Schechtman

Age of onset is varied. Fly biting is an uncommon idiopathic syndrome which is poorly understood. Theories on the cause include ...

https://en.wikipedia.org/wiki/Fly_biting

The onset is often gradual. Pain is made worse by movement of the thumb and wrist, and may radiate to the thumb or the forearm ... It may be most common in middle age. Symptoms are pain and tenderness at the radial side of the wrist, fullness or thickening ...

https://en.wikipedia.org/wiki/De_Quervain_syndrome

Onset is most common in two age ranges, between ages 16-25 and between ages of 36-46 years. Still's disease is named after ... Adult-onset Still's disease is rare and has been described all over the world. The number of new cases per year is estimated to ... Adult-onset Still's disease (AOSD) is a form of Still's disease, a rare systemic autoinflammatory disease characterized by the ... Adult-onset Still's disease is treated with anti-inflammatory medications. Steroids such as prednisone are used to treat severe ...

https://en.wikipedia.org/wiki/Adult-onset_Still's_disease

It occurs in any age group and prior tension is present. Initial cases can be identified and the spread is gradual. … [T]he ... symptoms with rapid onset and recovery; occurrence in a segregated group; the presence of extraordinary anxiety; symptoms that ... It was established that the outbreaks began among the 14-year-olds, but that the heaviest incidence moved to the youngest age ... Hecker, J. F. (1844). The Epidemics of the Middle Ages (First ed.). p. 118. Kerchoff, Alan C. (2013). "Analyzing a Case of Mass ...

https://en.wikipedia.org/wiki/Mass_psychogenic_illness

... reporting the behaviors before the age of 21. Fewer than 4% of people reported the onset of their symptoms after the age of 40 ... Grisham, Jessica R.; Frost, Randy O.; Steketee, Gail; Kim, Hyo-Jin; Hood, Sarah (2006). "Age of onset of compulsive hoarding". ... Ayers, Catherine R.; Saxena, Sanjaya; Golshan, Shahrokh; Wetherell, Julie Loebach (2014-01-24). "Age at onset and clinical ... it was found most reported the onset of their hoarding symptoms between the ages of 11 and 20 years old, with 70% ...

https://en.wikipedia.org/wiki/Compulsive_hoarding

In the aged and children, pain might not be the main presenting feature; the aged patient simply moves less, the infantile ... Onset can be gradual or sudden. There are over 100 types of arthritis. The most common forms are osteoarthritis (degenerative ... Arthritis is more common in women than men at all ages and affects all races, ethnic groups and cultures. In the United States ... Overall the disease becomes more common with age. Arthritis is a common reason that people miss work and can result in a ...

https://en.wikipedia.org/wiki/Arthritis

The age of onset is often ... Although the disease may be fulminant during onset, the acute ... Pediatric patients usually present with acute onset of hemolytic anemia with fatigue, exercise intolerance, pallor, jaundice, ...

https://en.wikipedia.org/wiki/Paroxysmal_cold_hemoglobinuria

In males over the age of 40 about 6 per 1,000 are affected a year. Among males over 80 this increases 30%. Onset can be sudden ... Onset can be sudden or gradual. When of sudden onset, symptoms include an inability to urinate and lower abdominal pain. When ... When the onset is sudden, symptoms include an inability to urinate and lower abdominal pain. When of gradual onset, symptoms ... By the age of 70, almost 10 percent of males have some degree of BPH and 33% have it by the eighth decade of life. While BPH ...

https://en.wikipedia.org/wiki/Urinary_retention

Onset is typically in middle age. The term "interstitial cystitis" first came into use in 1887. The most common symptoms of IC/ ... IC/BPS affects men and women of all cultures, socioeconomic backgrounds, and ages. Although the disease was previously believed ...

https://en.wikipedia.org/wiki/Interstitial_cystitis

W]e face threats [that include] global warming . . . weaponized microbes . . . the onset of another ice age . . . the ... "The Space Review: The Artemis Accords: repeating the mistakes of the Age of Exploration". The Space Review. Jun 29, 2020. ... But during the initial decades of the space age decolonization also gained again in force producing many newly independent ...

https://en.wikipedia.org/wiki/Space_colonization

A slow onset and a lack of pain or sensorial symptoms are arguments against a lesion of the spinal root or plexus brachialis. ... To an extent, these features can also be seen in normal aging (although technically, the apparent muscle wasting is sarcopenia ... Voermans NC, Schelhaas HJ, Munneke M, Zwarts MJ (December 2006). "Dissociated small hand muscle atrophy in aging: the 'senile ...

https://en.wikipedia.org/wiki/Split_hand_syndrome

The film was showcased at the 2016 Walt Disney Content Showcase in South Africa, where concept art, story details and on-set ... Burgess, Matthew (August 23, 2012). "Johnny Depp as Captain Jack Sparrow Pirates of the Caribbean 5". The Age. Archived from ... Graser, Marc (January 24, 2015). "Kaya Scodelario Boards Disney's 'Pirates of the Caribbean 5'". The Age. Archived from the ... Rønning felt de-aging Depp was tricky against the canon of the franchise. Javier Bardem as Captain Armando Salazar: The undead ...

https://en.wikipedia.org/wiki/Pirates_of_the_Caribbean:_Dead_Men_Tell_No_Tales

They biostratigraphically dated them to respectively the Montehermosan, Chapadmalalan, and Pampean (Ensenadan) Ages, according ... the Uruguayan climate evolved from a dry and semiarid one with sparse forest cover-coinciding with the onset of the Quaternary ... to the South American land mammal age geological timescale. On the international geologic time scale, the older two would ...

https://en.wikipedia.org/wiki/Josephoartigasia

The Jazz Age saw the popularization of flaps in dresses; and stars such as the entertainer Josephine Baker became known for ... The 1930s started in depression and ended with the onset of World War II. With rising unemployment and despair, no industry was ... While in this era, clothing became split along lines of age, there were overriding oversized trends including: midi skirts, ...

https://en.wikipedia.org/wiki/Women's_oversized_fashion_in_the_United_States_since_the_1920s

... which describes the state of affairs in a Spessart community in the waning years of the Middle Ages and the onset of the modern ... There have been archaeological finds in the area dating to the Stone Age, the Bronze Age, and the Iron Age. The locality was ... at Whitsuntide Bike-Marathon in late June Orchestral Hoffest after summer's onset Frammersbacher Festtage (Festival Days), but ...

https://en.wikipedia.org/wiki/Frammersbach

In November 1796, Prince Gustav was declared of age and become King Gustav IV Adolf. His accession restored von Fersen, and ... and other Swedish towns following the onset of a severe winter and famine. Von Fersen wrote: "Who, given the spirit that now ... Barton, Hildor Arnold (1 January 1975). Count Hans Axel von Fersen: An Aristocrat in an Age of Revolution. Twayne Publishers. ... were Swedish ladies-in-waiting and leading socialites of the Gustavian age. Von Fersen's ancestors came from Estonia to Sweden ...

https://en.wikipedia.org/wiki/Axel_von_Fersen_the_Younger

Unlike the general population that had to provide recruits between the ages of 18 and 35, Jews had to provide recruits between ... Following the Soviet annexation of over half of Poland at the onset of World War II, all Polish nationals including Jews were ... "Jews, by Country of Origin and Age". Statistical Abstract of Israel (in English and Hebrew). Israel Central Bureau of ... A relic of Kazimierz's Golden Age". Cracow-life.com. Retrieved 24 March 2013. Hundert 2004, p. 11. Hundert 2004, p. 19. Council ...

https://en.wikipedia.org/wiki/History_of_the_Jews_in_Poland

It was likely in a male, age between 20 and 50 years old. It is unknown how it was contracted, but likely skin-to-skin contact ... The time from exposure to onset of symptoms ranges from five to twenty-one days. The duration of symptoms is typically two to ... It was in a male of unknown age who had most likely contracted the disease from a trip to London, UK, which had already been ... It was in an adult of unknown exact age and gender who most likely contracted the disease from a trip to a country which had ...

https://en.wikipedia.org/wiki/2022_monkeypox_outbreak_in_North_America

"Population aging in New Zealand". Statistics New Zealand. "Brian Gaynor: NZ badly behind times with age pensions". The New ... until the onset of the 1997 Asian financial crisis again pushed the rate higher. By 2016 the unemployment rate decreased to 5.3 ... Everyone aged 65 years old or over, who is a New Zealand citizen or permanent resident and who normally lives in New Zealand at ... In the ten years from 2014, the number of New Zealanders over the age of 65 was projected to grow by about 200,000. This poses ...

https://en.wikipedia.org/wiki/Economy_of_New_Zealand

About 55% of MSA cases occur in men, with those affected first showing symptoms at the age of 50-60 years. MSA often presents ... April 2019). "Biallelic expansion of an intronic repeat in RFC1 is a common cause of late-onset ataxia". Nature Genetics. 51 (4 ... Those who present at an older age, those with parkinsonian features, and those with severe autonomic dysfunction have a poorer ... Approximately 60% of patients require a wheelchair within five years of onset of the motor symptoms, and few patients survive ...

https://en.wikipedia.org/wiki/Multiple_system_atrophy

After determining the timing of onset, duration and frequency of death rates of the disease, Louis then analyzed the timing of ... and attempted to account for factors such as age of patients in different treatment groups, diet, severity of illness and other ...

https://en.wikipedia.org/wiki/Pierre_Charles_Alexandre_Louis

"Abrupt onset of the Little Ice Age triggered by volcanism and sustained by sea-ice/ocean feedbacks" Geophysical Research ... It is believed that the Balochs migrated from Balochistan during the Little Ice Age. The Little Ice Age is conventionally ... Little Ice Ages: Ancient and Modern, Routledge, London (2 volumes) 2004. Matthews, J.A. and Briffa, K.R., "The 'Little Ice Age ... Lamb, HH (1972). "The cold Little Ice Age climate of about 1550 to 1800". Climate: present, past and future. London: Methuen. p ...

https://en.wikipedia.org/wiki/Baloch_people_in_Sindh

Abuse during childbirth Advanced maternal age, when a woman is of an older age at reproduction Antinatalism Asynclitic birth, ... Eclampsia is the onset of seizures (convulsions) in a woman with pre-eclampsia. Pre-eclampsia is a disorder of pregnancy in ... At the onset of the Industrial Revolution, giving birth at home became more difficult due to congested living spaces and dirty ... Definitions of the onset of labour include: Regular uterine contractions at least every six minutes with evidence of change in ...

https://en.wikipedia.org/wiki/Childbirth

At the age of 46 I put myself in a movie, dancing the Tango with the best tango dancer in the world. [...] It was so terrifying ... It follows Molly (Elle Fanning) caring for her father, Leo (Javier Bardem), who suffers from early-onset dementia. In an ... Potter began making amateur films at age 14, using an 8mm camera given to her by an uncle. She eventually dropped out of school ... at age 16 to pursue filmmaking. From 1968-1970 she worked as a kitchen worker and a picture researcher for BBC in order to ...

https://en.wikipedia.org/wiki/Sally_Potter

... but has since been weakened by invasions from other peoples and the onset of a three-way civil war. The Northern Calradic ... and European realms of the Early Middle Ages. The armour, clothes, weapons, and architecture of each faction are inspired by ...

https://en.wikipedia.org/wiki/Mount_&_Blade_II:_Bannerlord

The period from mid-April to late June (before the onset of the monsoon) is the hottest of the year, with highs peaking in May ... 75% of males and 65% of females over the age of 10 were literate in Hyderabad District in 2010, a region which includes rural ...

https://en.wikipedia.org/wiki/Hyderabad,_Sindh

Although AGE may occur as a result of other causes, it is most often secondary to PBT. AGE is the second most common cause of ... The table below summarises the results for the relative frequency of the symptoms, and the earliest and latest time of onset, ... The wide variety of symptoms and large variability of onset between individuals typical of oxygen toxicity are clearly ... and recorded the time of onset of various signs and symptoms. Five of the subjects convulsed, and the others recovered when ...

https://en.wikipedia.org/wiki/List_of_signs_and_symptoms_of_diving_disorders

A Bronze Age settlement near Chalat, commune of Vayres, has so far yielded only insignificant findings. From the early Iron Age ... Afterwards the sea retreated to come back again at the onset of the Cenomanian (Upper Cretaceous). A very warm epicontinental ... Due to the various ice ages, erosion has again increased since the Pleistocene − a good example for this being the Dronne. ...

https://en.wikipedia.org/wiki/Parc_naturel_régional_Périgord_Limousin

The time from exposure to onset of symptoms ranges from five to twenty-one days. The duration of symptoms is typically two to ... Cases are mostly in young and middle-aged men. This points to transmission due to close contact during sex as being the main ... People can spread the virus from the onset of symptoms until all the lesions have scabbed and fallen off; with some evidence of ... "Monkeypox (MPX) health alert". Department of Health and Aged Care. Retrieved 25 November 2022. "Factbox: Monkeypox cases and ...

https://en.wikipedia.org/wiki/2022_monkeypox_outbreak

In 1886, at age 19, Wright wanted to become an architect; he was admitted to the University of Wisconsin-Madison as a special ... which have since been identified as the onset of the "Prairie Style". Two, the Hickox and Bradley Houses, were the last ... ISBN 0-226-01366-9; Hersey, George (2000). Architecture and Geometry in the Age of the Baroque. University of Chicago Press. p ... but he died quietly on April 9 at the age of 91 years. The New York Times then reported he was 89. After his death, Wright's ...

https://en.wikipedia.org/wiki/Frank_Lloyd_Wright

This is a rare clinical complication that is often fatal within five days of the onset of the disease. In the early 1940s, ... It works best when started early and is recommended in all age groups, as well as during pregnancy. Antibiotics are not ... The rash first appears two to five days after the onset of fever, and it is often quite subtle. Younger patients usually ... Preventive therapy in healthy people who have had recent tick bites is not recommended and may only delay the onset of disease ...

https://en.wikipedia.org/wiki/Rocky_Mountain_spotted_fever

The exclusion of three allegations-all giving times to onset of problems in months-helped to create the appearance of a 14-day ... Poland GA, Jacobson RM (13 January 2011). "The Age-Old Struggle against the Antivaccinationists". The New England Journal of ... Influence of gestational age and birth weight". NeuroToxicology. doi:10.1016/j.neuro.2009.09.008. PMID 19800915. Wakefield, AJ ... Influence of gestational age and birth weight". Neurotoxicology. doi:10.1016/j.neuro.2009.09.008. PMID 19800915. Retracted: ...

https://en.wikipedia.org/wiki/Andrew_Wakefield

The army set out from Lamia on 21 January, and crossed the border on the next day, despite the onset of extreme cold and heavy ... As a member of the Athens garrison, Danglis took part in the festivities to celebrate the coming of age of the Crown Prince, ...

https://en.wikipedia.org/wiki/Panagiotis_Danglis

Hannibal needed to reach the Alps quickly in order to beat the onset of winter. He knew that if he waited until springtime on ... "Biostratigraphic evidence relating to the age‐old question of Hannibal's invasion of Italy", Archaeometry, vol, 59, 164-190. [1 ...

https://en.wikipedia.org/wiki/Hannibal's_crossing_of_the_Alps

People aged 16 and 17 are invited to get their first COVID vaccination, with GPs surgeries in England advised they can contact ... anecdotal evidence of terse exchanges between police officers and members of the public in the days following the onset of the ... Furthermore, children aged 12-15 will be offered a second vaccine, and the gap between second vaccines and a booster will be ... People aged over 40 in England become eligible to book their COVID booster vaccination. Holidaymakers are urged to use £132m in ...

https://en.wikipedia.org/wiki/Timeline_of_the_COVID-19_pandemic_in_the_United_Kingdom_(July–December_2021)

The mean age of onset of ischemic episodes is approximately 46 years (range 30-70). A classic lacunar syndrome occurs in at ... While MRI is not used to diagnose CADASIL, it can show the progression of white matter changes even decades before onset of ... And James Dewar, best known as vocalist for Robin Trower, died age 59 from complications of CADASIL. In the movie The Sea ... Likewise, the early death of the composer Felix Mendelssohn, at age 37, from a stroke has been potentially linked to CADASIL. ...

https://en.wikipedia.org/wiki/CADASIL

It was a golden age of short stories. She used a large cash prize from a short story magazine to finance her move to Chicago, ... From the onset, Glaspell's plays were also published in print form, receiving laudatory reviews by New York's most prestigious ... After covering the conviction of a woman accused of murdering her abusive husband, Glaspell abruptly resigned at age twenty- ...

https://en.wikipedia.org/wiki/Susan_Glaspell

The onset of this neurological disease is (on average) at age 45 and is invariably fatal within 10-20 years. Haldane assumed ... Ageing Aging brain Aging-associated diseases Anti-aging movement DNA repair Free radicals Genetics of aging Geriatrics ... evolutionary theories of aging and mechanistic theories of aging. Evolutionary theories of aging primarily explain why aging ... Two organisms of the same species can also age at different rates, making biological aging and chronological aging distinct ...

https://en.wikipedia.org/wiki/Senescence

At one point during the second to last season, Goodman walked off the set after Barr had an on-set outburst. It was speculated ... The character's circumstances as an aging manual laborer are also explored. Dan eventually begins a romantic relationship with ...

https://en.wikipedia.org/wiki/Dan_Conner

The onset of action of pemoline is gradual and therapeutic benefits may not occur until the third or fourth weeks of use. This ... The half-life is 7 hours in children but may increase to 11 to 12 hours with age. The relatively long half-life of pemoline ... New Age International. pp. 201-. ISBN 9788122415650. OCLC 818800751. Takeda, Toshinobu (March 2009). "Psychopharmacology for ...

https://en.wikipedia.org/wiki/Pemoline

Choose age-appropriate toys. Do not give small children toys that are heavy or fragile. Inspect toys for small or loose parts, ...

https://medlineplus.gov/ency/article/000012.htm

Onset of Regular Smoking at Age ,18 (95% CI). % Onset of Regular Smoking at Age 18-20 (95% CI). % Onset of Regular Smoking at ... Prevalence of age at onset of regular smoking and outcomes. Prevalence of onset of regular smoking before age 18, at age 18 to ... Onset of regular smoking at age 18 to 20 also was associated with higher nicotine dependence in adulthood than at age 21 or ... of age at onset of regular smoking and outcomes were reported. Association of age with nicotine dependence was assessed by ...

https://www.cdc.gov/pcd/issues/2020/19_0176.htm

The age of onset for schizophrenia is typically late adolescence to early adulthood. However, its not limited to this range ... Typical age of onset. The onset of schizophrenia usually occurs between the ages 16 and 30. Broken down by sex, the average age ... Experts say the average age at which people first experience psychosis is 24 years old. The oldest age of onset was 63 years ... Early onset schizophrenia. Healthcare professionals consider someone to have early onset schizophrenia, or childhood onset ...

https://psychcentral.com/schizophrenia/schizophrenia-age-of-onset

The objective of this study is to evaluate the association of clinical features and prognosis with age at disease onset in ... age at onset has an impact on SLE disease status, and infection is the main cause of death in those with late-onset lupus. ... Associations of clinical features and prognosis with age at disease onset in patients with systemic lupus erythematosus Lupus. ... The objective of this study is to evaluate the association of clinical features and prognosis with age at disease onset in ...

https://pubmed.ncbi.nlm.nih.gov/24297642/?dopt=Abstract

Although the variation in age at onset is partly explained by the size of the expanded repeat, the unexplained variation in age ... A genome scan for modifiers of age at onset in Huntington disease: The HD MAPS study Journal Article Overview abstract * ... at onset is strongly heritable (h2=0.56), which suggests that other genes modify the age at onset of HD. To identify these ... using ages at onset adjusted for the expanded and normal CAG repeat sizes. Because all those studied were HD affected, ...

https://www.healthpartners.com/knowledgeexchange/display/document-rn18491

The TOMMORROW Study: Design of an Alzheimers Disease Delay-of-Onset Clinical Trial Link to Resource: ... The TOMMORROW study: Design of an Alzheimers disease delay-of-onset clinical trial. Alzheimers & Dementia 2019;5:661-670. ... contains a sufficient number of participants at increased risk of cognitive impairment onset during the trial time frame to ... Design of an Alzheimers Disease Delay-of-Onset Clinical Trial ... National Advisory Council on Aging (NACA) Advances in Aging and ...

https://www.nia.nih.gov/research/alzheimers-dementia-outreach-recruitment-engagement-resources/tommorrow-study-design

We identified ,i ,C1C1-KIR2DS2/2DL2,/i, as an independent risk factor for earlier onset age of HCC (median onset age was 44 for ... genetic background can influence the onset age of HCC in male patients with HBV infection. This study may be useful to improve ... genetic background could influence the onset age of hepatocellular carcinoma (HCC) in patients with hepatitis B virus (HBV) ... We identified C1C1-KIR2DS2/2DL2 as an independent risk factor for earlier onset age of HCC (median onset age was 44 for C1C1- ...

https://www.hindawi.com/journals/jir/2013/874514/

Birth weights varied from 630 to 2700 g and gestational ages from 24.5 to 40.0 weeks. The median postnatal age at which acute ... Using postmenstrual age as the variable, the first signs of retinopathy of prematurity were seen over a fairly narrow age range ... The age at which retinopathy of prematurity was first seen was determined in 143 infants. In all, the initial ophthalmological ... These findings suggest that the age (but not the occurrence or severity) at which retinopathy of prematurity is first seen is ...

https://adc.bmj.com/content/61/8/774?ijkey=53a25723ecf0a03dbe11a8595310c7b173939e6e&keytype2=tf_ipsecsha

Clinton speaks on global warming leading to onset of ice age. A recent Associated Press article, 28 January 2006, quoted the ... Clinton called for "a serious global effort to develop a clean energy future" to avoid the onset of another ice age. ... No Replies to "Clinton speaks on global warming leading to onset of ice age". ...

https://www.remineralize.org/2007/12/clinton-speaks-on-global-warming-leading-to-onset-of-ice-age/

It was the first large-scale study to look at precancerous polyps in this age group. ... nationally representative study of patients under age 50 who underwent colonoscopy. ... researchers at the Icahn School of Medicine at Mount Sinai describe a troubling increase in early-onset colorectal cancer and ... Increasing incidence of early-onset colorectal precancerous lesions in patients under age 50. by The Mount Sinai Hospital ...

https://medicalxpress.com/news/2022-01-incidence-early-onset-colorectal-precancerous-lesions.html

summarize the prominent symptoms and age of symptom onset according to various forms of the illnesses (late infantile, early ... summarize the prominent symptoms and age of symptom onset according to various forms of the illnesses (late infantile, early ... Editors Note: Association of Age at Onset and First Symptoms With Disease Progression in Patients With Metachromatic ... Editors Note: Association of Age at Onset and First Symptoms With Disease Progression in Patients With Metachromatic ...

https://n.neurology.org/content/97/9/457.2?rss=1

McVicar, D., Moschion, J., & van Ours, J. C. (2018). Early illicit drug use and the age of onset of homelessness. Journal of ... McVicar, D, Moschion, J & van Ours, JC 2018, Early illicit drug use and the age of onset of homelessness, Journal of the ... McVicar, Duncan ; Moschion, Julie ; van Ours, Jan C. / Early illicit drug use and the age of onset of homelessness. In: Journal ... Early illicit drug use and the age of onset of homelessness. Journal of the Royal Statistical Society: Series A (Statistics in ...

https://pure.qub.ac.uk/en/publications/early-illicit-drug-use-and-the-age-of-onset-of-homelessness

Hypothalamic atrophy is related to body mass index and age at onset in amyotrophic lateral sclerosis ... Hypothalamic atrophy is related to body mass index and age at onset in amyotrophic lateral sclerosis ...

https://jnnp.bmj.com/content/88/12/1033.altmetrics

Prediction of age at onset. Based on a log-normal distribution of the age at onset, we obtained the age at onset for each ... Prediction of age at onset. Statistical model. The prediction of age at onset was achieved using a statistical model to relate ... therefore estimations of onset at the oldest ages are more theoretical than real. The ages at onset estimated in this study ... the expanded allele had a negative effect on the age at onset. For SCA1, the log of the age at onset decreased by 0.049±0.002 ( ...

https://jmg.bmj.com/content/51/7/479

... ... Title : Age at Pubertal Onset in Girls and Tobacco Smoke Exposure during Pre- and Post-natal Susceptibility Windows Personal ... Age at Pubertal Onset in Girls and Tobacco Smoke Exposure during Pre- and Post-natal Susceptibility Windows ... Higher urinary cotinine quartiles were associated with younger age at breast and pubic hair onset in unadjusted models, but not ...

https://stacks.cdc.gov/view/cdc/47609

The mean age of patients with a CA-MRSA infection (40.6 years, 95% CI 37.8-43.4) was significantly lower (P,0.0001), than the ... The mean age of patients (31.7 years, 95% CI 28.9-34.5) with a PVL positive CA-MRSA infection was significantly lower (P,0.0001 ... The mean age of patients with infections due to CA-MRSA strains (41 years; median 38 years) was found to be significantly lower ... The mean age of patients with PVL positive CA-MRSA infections (32 years; median 29 years) was significantly lower (P,0.0001) ...

http://alcohol.gov.au/internet/main/publishing.nsf/Content/cda-cdi3801l.htm

Study Shows that Consumption of a Pro-Inflammatory Diet is Associated with Increased Odds of Frailty Onset in Middle-Aged and ... Study Shows that Consumption of a Pro-Inflammatory Diet is Associated with Increased Odds of Frailty Onset in Middle-Aged and ... Hebrew SeniorLife also conducts influential research into aging at the Hinda and Arthur Marcus Institute for Aging Research, ... Courtney L. Millar, Ph.D., a Post-Doctoral Research Fellow, Hinda and Arthur Marcus Institute for Aging Research, and a ...

https://www.hebrewseniorlife.org/news/study-shows-consumption-pro-inflammatory-diet-associated-increased-odds-frailty-onset-middle-aged

The underlying white matter impairment in patients with early and late-onset Alzheimers disease (EOAD and LOAD) is still ... Consistent with previous studies, we dichotomized AD patients into early- and late-onset groups (age at onset 8, 14]. All ... Alzheimers disease (AD) can be commonly categorized as either early onset (EOAD) or late onset (LOAD) based on an age cutoff ... White matter microstructural damage in Alzheimers disease at different ages of onset. Neurobiol Aging. 2013; 34:2331-40. https ...

https://aging-us.com/article/202702/text

KD Age of onset in the group one was lower than group two (4.38 years VS 5.5 years, P-value = 0.044). There was no ... Age of onset for KD during the COVID-19 pandemic was lower and skin manifestation was higher than the same period time in last ... There was a significant difference in KD age of onset between two groups (p-value = 0.044), and KD age of onset was lower in ... KD Age of onset in the group one was lower than group two (4.38 years VS 5.5 years, P-value = 0.044). There was no difference ...

https://bmcpediatr.biomedcentral.com/articles/10.1186/s12887-021-03060-w

Clinical genetic implications of age-dependent onset",. abstract = "A biomathematical genetic model for the age-specific risk ... Clinical genetic implications of age-dependent onset. / Breitner, John C.S.; Murphy, Edmond A.; Folstein, Marshal F. ... Clinical genetic implications of age-dependent onset. In: Journal of Psychiatric Research. 1986 ; Vol. 20, No. 1. pp. 45-55. ... Clinical genetic implications of age-dependent onset. Journal of Psychiatric Research. 1986;20(1):45-55. doi: 10.1016/0022-3956 ...

https://jhu.pure.elsevier.com/en/publications/familial-aggregation-in-alzheimer-dementia-ii-clinical-genetic-im-4

Dive into the research topics of Relationship of APOE, age at onset, amyloid and clinical phenotype in Alzheimer disease. ... Relationship of APOE, age at onset, amyloid and clinical phenotype in Alzheimer disease. ...

https://mayoclinic.pure.elsevier.com/en/publications/relationship-of-apoe-age-at-onset-amyloid-and-clinical-phenotype-/fingerprints/

Validity of the age-of-onset criterion for ADHD: A report from the DSM- IV field trials ... Validity of the age-of-onset criterion for ADHD: A report from the DSM- IV field trials. Journal of the American Academy of ...

https://digitalcommons.lsu.edu/psychology_pubs/506/

Renal function, body surface area, and age are associated with risk of early-onset fluoropyrimidine-associated toxicity in ... Renal function, body surface area, and age are associated with risk of early-onset fluoropyrimidine-associated toxicity in ... Keywords: Age Factors, Aged, Antimetabolites, Antineoplastic, Antineoplastic Combined Chemotherapy Protocols, Area Under Curve ... age (OR 1.14 per decade, p = 0.0891), and elevated pre-treatment uracil concentrations (OR 2.41 per 10 ng/ml, p = 0.0046). Age ...

https://dspace.library.uu.nl/handle/1874/346170

... and performed genome-wide association testing to identify variants that modify age at onset (AAO) of Alzheimers disease. Our ... In this second cohort, the associated haplotype disrupted the typical age-associated increase of eotaxin-1 levels, suggesting a ... We have sequenced the complete genomes of 72 individuals affected with early-onset familial Alzheimers disease caused by an ... on chromosome 17 within a chemokine gene cluster associated with delayed onset of mild-cognitive impairment and dementia. ...

https://escholarship.org/uc/item/1gx1d02v

Dive into the research topics of Motor and non-motor symptoms in old-age onset Parkinsons disease patients. Together they ... Motor and non-motor symptoms in old-age onset Parkinsons disease patients. ...

https://novaresearch.unl.pt/en/publications/motor-and-non-motor-symptoms-in-old-age-onset-parkinsons-disease-/fingerprints/

Prepubertal organochlorine pesticide concentrations and age of pubertal onset among Russian boys. In: Environment international ... Prepubertal organochlorine pesticide concentrations and age of pubertal onset among Russian boys. / Lam, Thuy; Williams, Paige ... Prepubertal organochlorine pesticide concentrations and age of pubertal onset among Russian boys. Environment international. ... Dive into the research topics of Prepubertal organochlorine pesticide concentrations and age of pubertal onset among Russian ...

https://pennstate.pure.elsevier.com/en/publications/prepubertal-organochlorine-pesticide-concentrations-and-age-of-pu

A middle-aged woman with acute onset of fever, altered mental status, and movement disorder. ... A 60-year-old woman was admitted in the emergency room with acute onset of fever, altered mental status, and movement disorder ...

https://efim.org/education/ejim/january-2021/middle-aged-woman-acute-onset-fever-altered-mental-status-and-movement

Preventing Burnout in the Age of Tech Innovation. Perhaps the greatest threat to filmmakers on-set well-being today is the ... On-set Therapists. No matter how much you may love your job, the undeniable fact is that filmmaking can be incredibly stressful ... This is why the well-being of production teams often depends on the availability of highly qualified on-set mental healthcare ... can quickly give rise to burnout if proactive on-set measures are not taken. When youre on set, though, and the budget is ...

https://www.productionhub.com/blog/post/tips-for-achieving-better-on-set-well-being

Pathogenic implications of age of onset in juvenile rheumatoid arthritis. Arthritis Rheum. 1975 May-Jun. 18(3):251-5. [QxMD ... Generally, children who were 6 years of age or younger at onset (especially of oligoarticular and psoriatic arthritis) and have ... Systemic-Onset Juvenile Idiopathic Arthritis. A definite diagnosis of systemic-onset JIA must await the development of ... Systemic-onset juvenile idiopathic arthritis. The complications that may occur in systemic-onset JIA are pericarditis, ...

https://www.medscape.com/answers/1007276-43073/what-is-the-significance-of-involvement-of-a-few-small-joints-in-the-hands-in-juvenile-idiopathic-arthritis-jia

Roundup: U.S. Cancer Deaths Continue Decline, Annual Report Says; Benefits of Quitting Smoking at Younger Ages; and COVIDs ... However, researchers said the risk of developing new-onset diabetes was greater as the severity of COVID symptoms intensified. ... Roundup: COVID Linked to Risk of Diabetes Onset; U.S. Testing mRNA Vaccines Against HIV; and More. ... Roundup: COVID Linked to Risk of Diabetes Onset; U.S. Testing mRNA Vaccines Against HIV; and More ...

https://baptisthealth.net/baptist-health-news/roundup-covid-linked-to-risk-of-diabetes-onset-u-s-testing-mrna-vaccines-against-hiv-and-more/?cat=science

Though it's most common for people to begin experiencing their first symptoms in late adolescence or early adulthood , early or late onset schizophrenia is also possible. (psychcentral.com)
Like early onset schizophrenia, late onset schizophrenia is rare. (psychcentral.com)
Logistic regression confirmed that patients with juvenile- and early-onset disease were associated with high incidence of being untreated prior to admission, and with low incidence of comorbidities as well as deaths caused by infection compared to patients with late-onset lupus. (nih.gov)
In conclusion, age at onset has an impact on SLE disease status, and infection is the main cause of death in those with late-onset lupus. (nih.gov)
Considering that the late-onset patients had simultaneously easily controllable diseases and high incidence of comorbidities, a different treatment strategy from younger patients should be considered. (nih.gov)
Background: The underlying white matter impairment in patients with early and late-onset Alzheimer's disease (EOAD and LOAD) is still unclear, and this might due to the complex AD pathology. (aging-us.com)
Alzheimer's disease (AD) can be commonly categorized as either early onset (EOAD) or late onset (LOAD) based on an age cutoff of 65 years [ 1 ]. (aging-us.com)
This study will determine the difference in manifestations and disease progression between patients with young, typical, and late onset adult HD at different stages of disease. (tremorjournal.org)
Age groups were defined as young onset (YO: 20-29 years), typical onset (TO: 30-59 years), and late onset (LO: 60+ years). (tremorjournal.org)
Everyone is fine now, but we learned that he had somehow contracted late-onset group B strep and had to be on antibiotics for two weeks. (groupbstrepinternational.org)
But we learned that there are rare cases where a baby will get late-onset group B strep from 7 days old to 3 months old. (groupbstrepinternational.org)
These patterns can further lead to a late onset of an actual disorder or the reoccurrence of a prior problem. (selfgrowth.com)

Healthcare professionals consider someone to have early onset schizophrenia, or childhood onset schizophrenia (COS), when their symptoms begin before the age of 13 years . (psychcentral.com)
summarize the prominent symptoms and age of symptom onset according to various forms of the illnesses (late infantile, early juvenile, late juvenile, and adult). (neurology.org)
In younger persons (under age 6 years), motor manifestations with or without cognitive impairment were common, whereas in late juvenile and adult forms, cognitive symptoms became increasingly common. (neurology.org)
Comparing to LOAD, EOAD has relatively more aggressive disease course and shorter survival time [ 2 ], and their clinical symptoms are usually more occult despite occurring at a younger age. (aging-us.com)
However, researchers said the risk of developing new-onset diabetes was greater as the severity of COVID symptoms intensified. (baptisthealth.net)
Under current guidelines, intravenous thrombolysis is used to treat acute stroke only if it can be ascertained that the time since the onset of symptoms was less than 4.5 hours. (nih.gov)
While the symptoms of the disease are mostly the same at whatever age it develops, younger people will experience the disease differently due to their unique life circumstances. (apdaparkinson.org)
These doctors also may have experience dealing with early onset Parkinson's symptoms. (apdaparkinson.org)
A polyT repeat in an intronic polymorphism (rs10524523) in the TOMM40 gene, which encodes an outer mitochondrial membrane translocase involved in the transport of amyloid-β and other proteins into mitochondria, has been implicated in Alzheimer's disease and APOE-TOMM40 genotypes have been shown to modify disease risk and age at onset of symptoms. (edu.au)
Tao PY, Leng L, Liu K, Zhou RH, Hu YC, Wu SJ, Xiao YD, Liu J. Determination of risk factors for predicting the onset of symptoms in asymptomatic COVID-19 infected patients. (medsci.org)
The purpose of this study is to investigate the risk factors of symptoms onset and clinical features in asymptomatic COVID-19 infected patients. (medsci.org)
Presence or absence at the onset of symptoms was taken as the outcome. (medsci.org)
A Cox regression model was performed to evaluate the potential predictors of the onset of symptoms. (medsci.org)
Cox regression analysis showed that smoking history (P=0.028, hazard ratio=4.49, 95% CI 1.18-17.08) and existence of pulmonary disease (P=0.038, hazard ratio=7.09, 95% CI 1.12-44.90) were risk factors of the onset of symptoms in asymptomatic carries. (medsci.org)
If you develop symptoms of COPD at a very young age, typically under 40 years of age, your physician may screen for this condition. (healthline.com)
The progression of the disease can vary slightly, so it's more important to focus on possible COPD symptoms rather than solely on the age you might get it. (healthline.com)
Some studies looked at the age when symptoms of the disorder began, some looked at when they were first diagnosed, and others looked at when they first received treatment for the disorder or were first hospitalized for it. (vikkisuttonpsychblog.com)
The median age of onset for some disorders, such as substance use disorders, mood disorders and anxiety disorders was earlier when it was measured by first symptoms than when it was measured by first diagnosis or first hospitalization. (vikkisuttonpsychblog.com)
Apart from the above-mentioned, there are so many symptoms that indicate the onset of seizures. (drchandrilchugh.com)
In this study, the authors sought to retrospectively characterize the initial complaint (onset of the first symptoms) and course of care of young AD patients, with or without work activity, and to compare their neuropsychological profiles at the time of diagnosis with those of elderly patients. (cea.fr)
And there needs to be no alternative plausible diagnosis, and the person is positive for current or recent SARS-CoV-2 infection by RT-PCR, serology, or antigen testing, or has had exposure to a suspected or confirmed COVID-19 case within the four weeks prior to the onset of symptoms. (cdc.gov)
A combination of maternal factors and a uterine arteries pulsatility index (UtA-PI) of 11 +0 to 13 +6 weeks presented good results in the prediction of early PE (onset of clinical symptoms before 34 weeks of pregnancy) [ 7 ]. (hindawi.com)
Young-onset dementia When symptoms of dementia start before the age of 65, we use the term "young onset dementia. (alzheimer.ca)
I have had three sudden-onsets of symptoms, in June 2018, May 2020 and January 2021, all with various psychological and neurological symptoms which have resulted in numerous diagnoses but which have all been treatment-resistant, with medications giving terrible side effects. (latitudes.org)
My first sudden-onset in 2018 is mostly in remission currently, whilst I still deal with all the symptoms from May 2020's and January 2021's. (latitudes.org)
Basically, from this, I was wondering if I have to have another sudden-onset of symptoms in order to receive treatment (and be tested diagnosed, although I know that some doctors will diagnose off of medical history), or if I can receive treatment now? (latitudes.org)
As baby boomers hit retirement age, there are more arthritis symptoms, and there's more arthritis in general. (everydayhealth.com)
The age, developmental stage, or period of life at which a disease or the initial symptoms or manifestations of a disease appear in an individual. (bvsalud.org)

We have sequenced the complete genomes of 72 individuals affected with early-onset familial Alzheimer's disease caused by an autosomal dominant, highly penetrant mutation in the presenilin-1 (PSEN1) gene, and performed genome-wide association testing to identify variants that modify age at onset (AAO) of Alzheimer's disease. (escholarship.org)
Alzheimer's disease is not a normal part of aging, and is irreversible. (alzheimer.ca)
LATE-NC Limbic-predominant age-related TDP-43 encephalopathy (or LATE-NC) is the most recently identified form of dementia, noted for its close similarity to Alzheimer's. (alzheimer.ca)
Women account for 58% of those diagnosed with early-onset dementia and Alzheimer's disease combined. (self.com)

BACKGROUND: The objective of this analysis was to determine the factors associated with early onset treatment-related toxicity in patients treated with capecitabine-based anticancer regimens in daily clinical care. (uu.nl)

BOSTON - Results of a study published in the American Journal of Clinical Nutrition indicate that regularly consuming a diet of pro-inflammatory foods (e.g., those rich in simple carbohydrates or in saturated fats) is associated with increased likelihood of developing frailty in middle-aged and older adults. (hebrewseniorlife.org)
COPD is most prevalent in older and middle-aged adults, but it's not a normal part of aging . (healthline.com)
This is especially true if you are age 50 or older - one type of headache that can newly develop in middle-aged people is giant cell arteritis. (verywellhealth.com)
This middle-aged man with no history of psychiatric illness was hospitalized in the ICU fo. (psychiatrist.com)

Adult smokers who started smoking regularly at age 18 to 20 years were more likely to experience high levels of nicotine dependence and less likely to attempt or intend to quit in adulthood compared with those who started at age 21 or older. (cdc.gov)
This study assessed the association of regular smoking initiation before age 21 years with nicotine dependence and cessation behaviors among US adult smokers. (cdc.gov)
The aim of this study in Tunisia was to classify ketosis-onset diabetes in adult patients. (who.int)
There should be Young Adult-onset Conduct Disorder to capture long-term history of Conduct Disorder prier to age 18. (wrongplanet.net)
The Young Adult-onset Conduct Disorder will also capture antisocial traits that young adults have, and once they turn 26 and six months old, then they will be given the diagnosis of (one or more) Personality Disorders. (wrongplanet.net)
For some reason, DSM-5-TR and ICD-11 did not emphasize that from ages 18-25, your brain and body as not exactly finished growing yet and that there should be Young Adult-onset Conduct Disorder for those age groups. (wrongplanet.net)
Using Social Security administrative data from the Adult Disability Report, we find that the median period from onset to application is 7.6 months. (ssa.gov)

A definite diagnosis of systemic-onset JIA must await the development of arthritis. (medscape.com)
When someone who is 21-50 years old receives a diagnosis of Parkinson's disease, it is referred to as early onset Parkinson's disease, or young onset Parkinson's disease (YOPD). (apdaparkinson.org)
What sets young onset Parkinson's apart from a diagnosis at an older age? (apdaparkinson.org)
Borderline PD is detectable by early adolescence and relatively stable from adolescence until adulthood, so it'd actually make more sense to put the minimum age for diagnosis around 10 or so. (wrongplanet.net)
By saying diagnosis should not happen until age 25 does not admit to struggles before that. (wrongplanet.net)
A training effort for health and information professionals is absolutely necessary in order to improve the diagnosis of early-onset AD and allow patients to have access to specialized care and the possibility of being included in therapeutic trials. (cea.fr)
For many, diagnosis may come seven to 10 years after the onset of the disease. (coastalcourier.com)
70 years of age v onset diagnosis ⩾70 years of age). (bmj.com)

Because the majority of people who get Parkinson's disease are over the age of 60, the disease is often overlooked in younger people, leading many to go undiagnosed or misdiagnosed for extended periods of time. (apdaparkinson.org)
About 10%-20% of those diagnosed with Parkinson's disease are under age 50, and about half of those are diagnosed before age 40. (apdaparkinson.org)
Approximately 60,000 new cases of Parkinson's are diagnosed each year in the United States, meaning somewhere around 6,000 - 12,000 are young onset patients. (apdaparkinson.org)
We read with interest the recent meta-analysis of seven studies that reported that the age-adjusted incidence of Parkinson's disease was 1.5 times greater in men than in women. (bmj.com)
In the process of updating our previous systematic review of studies on the incidence of Parkinson's disease, 2 we performed a new meta-analysis of age-adjusted M:F incidence ratios for Parkinson's disease and attempted to identify the causes of heterogeneity. (bmj.com)

A biomathematical genetic model for the age-specific risk of Alzheimer Dementia (AD) was applied to two problems in the clinical genetics of this disorder. (elsevier.com)
Our analysis identified a haplotype of single-nucleotide polymorphisms (SNPs) on chromosome 17 within a chemokine gene cluster associated with delayed onset of mild-cognitive impairment and dementia. (escholarship.org)
The differences between normal aging and dementia If you are experiencing difficulties with memory, know that they may not be signs of dementia. (alzheimer.ca)
It should be noted that the rate of "not stated" responses to questions in the Census are often relatively high for people with dementia, particularly for people living in residential aged care. (aihw.gov.au)
A smaller proportion of younger people who died with dementia (aged 35-74) were born in non-English speaking countries (15%) compared with people aged 75 and over (21%) (Figure 13.7). (aihw.gov.au)

The objective of this study is to evaluate the association of clinical features and prognosis with age at disease onset in patients with systemic lupus erythematosus (SLE) in a large, multicenter Chinese cohort. (nih.gov)
To investigate whether killer cell immunoglobulin-like receptor (KIR) and human leukocyte antigen (HLA) genetic background could influence the onset age of hepatocellular carcinoma (HCC) in patients with hepatitis B virus (HBV) infection, one hundred and seventy-one males with HBV-related HCC were enrolled. (hindawi.com)
We conclude that KIR and HLA genetic background can influence the onset age of HCC in male patients with HBV infection. (hindawi.com)
Knowledge on the factors that influence the onset age of HCC will improve current HCC surveillance program in HBV-infected patients. (hindawi.com)
In a study published in the journal Gastroenterology , researchers at the Icahn School of Medicine at Mount Sinai describe a troubling increase in early-onset colorectal cancer and precancerous polyps, based on a large, nationally representative study of patients under age 50 who underwent colonoscopy. (medicalxpress.com)
Among patients aged 45-49, 32 percent had neoplasia (precancerous or cancerous lesions considered forerunners to colorectal cancer). (medicalxpress.com)
We studied approximately 131,000 patients ages 40-49, which represents a significant increase over previous studies which have been limited by small sample sizes, underrepresentation of several racial/ethnic groups, or came from a single institution," says first author Parth D. Trivedi, a fourth-year medical student at Icahn Mount Sinai, who helped design the study and provided statistical analysis. (medicalxpress.com)
Patients with earlier disease onset experienced more rapid progression. (neurology.org)
In 2012, the Australian Group on Antimicrobial Resistance (AGAR) conducted a community-onset period-prevalence survey of clinical Staphylococcus aureus isolated from hospital outpatients and general practice patients including nursing homes, long term care facilities and hospice patients. (alcohol.gov.au)
0.0001), than the mean age of patients with a PVL negative CA-MRSA infection (55.7 years, 95% CI 50.7-60.6). (alcohol.gov.au)
Surprisingly, EOAD patients have a higher burden of amyloid deposition and neurofibrillary tangles than LOAD in frontal and parietal lobes [ 7 - 9 ], which is incompatible with their aging process. (aging-us.com)
CONCLUSION: Renal function, BSA, and age, in addition to pre-treatment uracil, are associated with clinically relevant differences in risk of early severe toxicity in patients treated with capecitabine in routine clinical care. (uu.nl)
We sought to determine whether patients with stroke with an unknown time of onset and features suggesting recent cerebral infarction on magnetic resonance imaging (MRI) would benefit from thrombolysis with the use of intravenous alteplase. (nih.gov)
In a multicenter trial, we randomly assigned patients who had an unknown time of onset of stroke to receive either intravenous alteplase or placebo. (nih.gov)
In patients with acute stroke with an unknown time of onset, intravenous alteplase guided by a mismatch between diffusion-weighted imaging and FLAIR in the region of ischemia resulted in a significantly better functional outcome and numerically more intracranial hemorrhages than placebo at 90 days. (nih.gov)
Using the large database of HD patients from Enroll-HD, we characterized HD phenotype and functional decline by age group across the spectrum of disease severity. (tremorjournal.org)
Knowledge of the phenotypic profile and rate of progression by age of onset will inform standard of care recommendations and aim to improve the quality of care for HD patients. (tremorjournal.org)
For this reason, young onset patients are usually initially treated with alternatives to levodopa. (apdaparkinson.org)
In conclusion, metabolic profiling of COVID-19 patients at disease onset is a powerful tool to unravel the SARS-CoV-2 molecular pathogenesis. (frontiersin.org)
History of smoking and pulmonary disease was prone to illness onset in asymptomatic patients, and it is necessary to be highly vigilant to those patients. (medsci.org)
In order to take into account the age of retirement, they focused their work on patients under 62 years old. (cea.fr)
Two of the patients died 7 days after disease onset. (cdc.gov)
We do not know where that person lives, or the age range of any of the patients. (foodpoisoningbulletin.com)
One of the patients had close contact with swine prior to illness onset. (cdc.gov)
6 months) and multiple oral ulcers, predominantly affecting plaint of painful gingiva and generalized burning mouth sen- women and elderly patients, between the ages of 60-80 years4. (bvsalud.org)

However, nimodipine treatment from 24-30 months significantly reduced the amount of microvascular deposition products in cortical layers I and III, while an earlier onset (16 months) of the drug application resulted in a significant reduction in all motor cortex layers studied. (rug.nl)
may be linked to a delay in the onset of menopause, while eating refined carbs, such as rice and pasta, may be linked to an earlier onset, the researchers found. (livescience.com)

This study contributes to literature that examines how much time typically passes between disability onset and application for disability-program benefits. (ssa.gov)
Because it also records the application filing date, this data source shows the amount of time that elapsed between disability onset and DI application, which we refer to as filing time . (ssa.gov)
Plaintiff's disability onset date was amended to June 5, 2007. (justia.com)
Amendment of Plaintiff's disability onset date was appropriate in light of Title XVI 17 18 19 eligibility. (justia.com)
3. Plaintiff had not engaged in substantial gainful activity since the alleged disability onset date of June 5, 2007. (justia.com)

The study, titled "Prevalence and Predictors of Young-Onset Colorectal Neoplasia: Insights from a Nationally Representative Colonoscopy Registry," was published today. (medicalxpress.com)

Courtney L. Millar, Ph.D., a Post-Doctoral Research Fellow, Hinda and Arthur Marcus Institute for Aging Research , and a Research Fellow, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, is the lead author of the study, "A Pro-Inflammatory Diet is Associated with Increased Odds of Frailty after 12-Year Follow-up in a Cohort of Adults. (hebrewseniorlife.org)
Validating this association, we found plasma eotaxin-1 levels were correlated with disease AAO in an independent cohort from the University of California San Francisco Memory and Aging Center. (escholarship.org)
In this second cohort, the associated haplotype disrupted the typical age-associated increase of eotaxin-1 levels, suggesting a complex regulatory role for this haplotype in the general population. (escholarship.org)
Researchers from centers in Finland and the USA compared the course of brain and cognitive aging in a population-based cohort of subjects with uncomplicated COE and matched controls, followed for approximately 55 years. (neurodiem.pl)
Methods: The Age, Gene/Environment Susceptibility-Reykjavik Study (AGES-RS) 2002-2006, interviewed and examined a population-based cohort of 5,764 adults aged 66-96 years. (cdc.gov)
So, she decided to use survey data from the U.K. Women's Cohort Study, which allowed her and her colleagues to examine the eating habits of women before they reached menopause and then compare that information with the women's actual age of menopause. (livescience.com)

Objective: To evaluate the associations of serum OCP concentrations [hexachlorobenzene (HCB), β-hexachlorocyclohexane (β-HCH), and p,. p'-dichlorodiphenyldichloroethylene (p,. p'-DDE)] with male pubertal onset. (elsevier.com)
We used multivariable interval-censored models to evaluate associations of OCPs (quartiles) with physician-assessed pubertal onset. (elsevier.com)
There were no associations of serum β-HCH and p,. p'-DDE concentrations with age of pubertal onset. (elsevier.com)

Suggestive evidence for linkage was found at 4p16 (LOD=1.93), 6p21-23 (LOD=2.29), and 6q24-26 (LOD=2.28), which may be useful for investigation of genes that modify age at onset of HD. (healthpartners.com)

One explanation is that a child's innate immune system mounts a more vigorous attack at the onset of infection. (forbes.com)
In the United States, roughly 3 in 10,000 people under the age of 21 were reported to have been diagnosed with a case of MIS-C infection, and there is an approximately 0.8% chance of mortality. (forbes.com)

The onset of pedophilia comes before adulthood, often during adolescence. (psychologytoday.com)
They have a later onset, usually in adulthood, and are primarily seen in women. (logicalimages.com)

WESTCHESTER, Ill. - A study in the Dec.1 issue of the journal Sleep suggests that changes in children's sleep patterns that typically occur between the ages of 11 and 12 years are evident before the physical changes associated with the onset of puberty. (eurekalert.org)
These lesions begin at the onset of puberty. (logicalimages.com)

Diabetes is the leading cause of new cases of blindness in people ages 20-74. (coastalcourier.com)

KD is an acute onset systemic vasculitis involving medium and small-sized arteries with a predilection toward the coronary arteries [ 1 ]. (biomedcentral.com)
A 60-year-old woman was admitted in the emergency room with acute onset of fever, altered mental status, and movement disorder. (efim.org)

In carriers of APOE ε3/ε3 or ε3/ε4, genotypes with a very long (VL) poly-T repeat were under-represented in s-IBM compared to controls and were associated with a later age at symptom onset, suggesting that these genotypes may be protective. (edu.au)

These findings suggest that the age (but not the occurrence or severity) at which retinopathy of prematurity is first seen is controlled predominantly by stage of development rather than neonatal events. (bmj.com)
Objective: The objective of this paper is to identify genes, pathways and networks implicated in age at onset (AAO) and severity, measured using the Multiple Sclerosis Severity Score (MSSS), of primary-progressive MS (PPMS). (elsevier.com)
Conclusions: Despite the fact that no major effect signals emerged in the present GWAS, our data suggest that genetic variants acting in the context of oxidative stress and immune dysfunction could modulate the onset and severity of PPMS. (elsevier.com)
This study compares HD manifestations while controlling for disease severity, detailing robust phenotypic differences by age of onset alone. (tremorjournal.org)
Therefore, we aimed to characterize metabolic and cytokine profile at COVID-19 onset and its relationship with disease severity to identify metabolic profiles predicting disease progression. (frontiersin.org)

The odds of developing childhood-onset schizophrenia are roughly 1 in 10,000 . (psychcentral.com)
New data have highlighted signs of accelerated brain and cognitive aging in people with childhood-onset epilepsy (COE) who are now in their 60s, particularly in those with active disease. (neurodiem.pl)

We have known for many years that rates of colorectal cancer are rising in individuals younger than 50, prompting several medical organizations to recommend lowering the screening age from 50 to 45. (medicalxpress.com)
Increasing age, being male and white, having a family history of colorectal cancer, and having had colonoscopies for reasons of bleeding or screening, were all associated with higher odds of advanced premalignant lesions (APLs) and colorectal cancer. (medicalxpress.com)
Moreover, among 40-44 year olds, rates of APL were almost as high as for those aged 45-49, and colorectal cancer rates were comparably high. (medicalxpress.com)
Early-onset colorectal cancer accounts for approximately 12 percent of all colorectal cancer cases, with incidence increasing by 2.2 percent annually from 2012-2016, and mortality increasing by 1.3 percent per year from 2008-2017. (medicalxpress.com)

The criteria include an individual aged less than 21 years presenting with fever, laboratory evidence of inflammation, and evidence of clinically severe illness requiring hospitalization with multisystem, that's two or more, organ involvement, including cardiac renal, respiratory hematologic, GI, derm, or neuro. (cdc.gov)
Twenty-five years ago, when your parents were your age, they didn't always know what caused their illness. (coastalcourier.com)
Illness onset dates ranged from March 28, 2022 to May 6, 2022. (foodpoisoningbulletin.com)
We do know that the last illness onset date was May 6, 2022. (foodpoisoningbulletin.com)
We do not know the states where the ill persons live, their age range, illness onset dates, or if anyone has been hospitalized. (foodpoisoningbulletin.com)
18 years of age, were not hospitalized, and have recovered or are recovering from their illness. (cdc.gov)
Pyuria in KD subjects was not correlated with age or day of illness. (lww.com)

Sudden onset of seizures in old age is generally a cause of past medical history. (drchandrilchugh.com)
Seizures in old age can often go undiagnosed because one links them with problems related to aging, but on the contrary, it may be due to the sudden onset of seizures in old age. (drchandrilchugh.com)
Suspect when there is a sudden onset of trouble breathing and widespread hives. (healthychildren.org)
Suspect when there is a sudden onset of coughing and choking. (healthychildren.org)
In May 2020 I developed severe sudden onset motor and vocal tics and in January 2021, I developed frequent non-epileptic seizures (about 100 a day), sleep issues, episodic paralysis and mobility difficulties. (latitudes.org)
Introduction: Age-related hearing loss (ARHL) is a common sensorineural disorder in older adults, who typically experience gradual rather than sudden onset of disabling hearing impairment (HI). (cdc.gov)
It has a sudden onset with high morbidity and mortality. (bvsalud.org)

This may occur at onset of the fever and rash or may lag by months or, rarely, years. (medscape.com)
An acute, highly contagious disease affecting swine of all ages and caused by the CLASSICAL SWINE FEVER VIRUS . (bvsalud.org)

[2] Because of the genetic defect in DNA repair, cells from people with FA are sensitive to drugs that treat cancer by DNA crosslinking , such as mitomycin C . The typical age of death was 30 years in 2000. (wikipedia.org)

This onset is mostly in remission now, however, I still have OCD and mild social and generalised anxiety (my sleep disturbances were in remission, however, they came back in January 2021). (latitudes.org)

To our knowledge, this is the largest study to date investigating the prevalence of precancerous and cancerous lesions in the colon in this age group. (medicalxpress.com)
Conclusion: In AGES-RS, disabling HI prevalence increased markedly with age. (cdc.gov)
Children diagnosed with PTS were a median of 2 years younger than those without PTS, with increased prevalence of seizures (83% v. 38%) in children below 2 years of age. (who.int)

Predictors of early grade ≥ 3 toxicity, after adjustment for treatment regimen, were renal function (odds ratio [OR] 0.85 per 10 ml/min/1.73 m(2), p = 0.0007), body surface area (BSA) (OR 0.33 per m(2), p = 0.0053), age (OR 1.14 per decade, p = 0.0891), and elevated pre-treatment uracil concentrations (OR 2.41 per 10 ng/ml, p = 0.0046). (uu.nl)

This study examined whether delaying regular smoking until after age 21 had additional health benefits beyond those associated with delaying regular smoking until after age 18. (cdc.gov)
It was the first large-scale study to look at precancerous polyps in this age group. (medicalxpress.com)
Our study provides an important piece of the puzzle and supports the recommendation changing the screening age to 45," says lead author Steven H. Itzkowitz, MD, FACP, FACG, AGAF, Professor of Medicine (Gastroenterology), Icahn School of Medicine at Mount Sinai. (medicalxpress.com)
This study was funded by the National Institute of Aging (NIA) AG051728 and the Heart, Lung and Blood Institute's Framingham Heart Study (NHLBI) contract numbers HHSN268201500001I and N01-HC 25195. (hebrewseniorlife.org)
The study included 36 males and 34 females with a mean age of 33.24±20.40 years (range, 0.5-84 years). (medsci.org)
Results show that over the two-year course of the study, sleep onset was significantly delayed by an average of 50 minutes, and sleep time was significantly reduced by an average of 37 minutes. (eurekalert.org)
A nationwide study of the relationship of AA with associated diseases stratified by onset age has rarely been reported. (nycu.edu.tw)
The participants were young children when the study began, and had a mean age of 63 years in 2017. (neurodiem.pl)
Hearing loss and associated risk factors among older adults: the Age, Gene/Environment Susceptibility-Reykjavik Study (AGES-RS). (cdc.gov)
Eating certain foods may be linked to a delayed or hastened onset of menopause, a new study from England finds. (livescience.com)
As such, we cannot really recommend women to consume these specific foods to influence their onset of natural menopause," said lead study researcher Yashvee Dunneram, a doctoral student in the School of Food Science and Nutrition at the University of Leeds in England. (livescience.com)
Demographic variables (age, sex, type of tinnitus) and baseline THI scores of placebo (n = 16) and treatment (n = 11) groups did not significantly differ from one another at the start of the study. (banishtinnitus.net)
2 Where possible, the age-standardised M:F incidence ratio for each study was calculated with the Confidence Interval Analysis software V.1 by applying the age-specific female incidence rates to the corresponding male population. (bmj.com)
However, there was significant heterogeneity between studies, which was only partly explained by mean age of onset and study location. (bmj.com)

Ensuring that the trial population, cognitively normal at outset, contains a sufficient number of participants at increased risk of cognitive impairment onset during the trial time frame to avoid prohibitive trial size and duration. (nih.gov)

Conclusion: Higher prepubertal serum HCB concentrations were associated with later age of gonadarche and pubarche. (elsevier.com)

Age-related macular degeneration (AMD), akin to other common age-related diseases, has a complex pathogenesis and arises from the interplay of genes, environmental factors, and personal characteristics. (elsevier.com)
With regards to the risk factors socioeconomic level, age, poor oral hygiene status, plaque index and gingival bleeding , the statistical results indicated that each of these factors showed highly significant relationships with AgP. (bvsalud.org)

2015). Chronic obstructive pulmonary disease among adults aged 18 and over in the United States, 1998-2009. (healthline.com)

What's the Usual Age of Onset for Schizophrenia? (psychcentral.com)
An important thing to note is that the onset of schizophrenia can look different from person to person, as this condition can take a variety of forms. (psychcentral.com)
The onset of schizophrenia usually occurs between the ages 16 and 30 . (psychcentral.com)
Early onset can be harder to diagnose because clinicians have to distinguish between a child's benign imaginative play and delusions or hallucinations that are related to schizophrenia. (psychcentral.com)
It's usually not until later in the teenage years that someone with early onset schizophrenia experiences thought disorder. (psychcentral.com)
Regardless of how difficult it can be for healthcare professionals to diagnose schizophrenia in children, if you believe that someone close to you might be experiencing early onset schizophrenia, it's important to say something. (psychcentral.com)

There is no particular seizure onset age or seizure onset time, but the risk increases as one gets older, particularly after entering your fifties. (drchandrilchugh.com)
Results/Conclusions: Similar to recent meta- and pooled analyses, our data suggest a lower PD risk in subjects who were either homozygous or heterozygous for the SNCA REP1 259 genotype, and a higher risk in subjects who were either homozygous or heterozygous for the REP1 263 genotype, especially among subjects with an age of onset ≤ 68 years. (cdc.gov)
More importantly, while analyses of interactions were limited by small cell sizes, risk due to SNCA variations seemed to vary with pesticide exposure and smoking, especially in younger onset cases, suggesting an age-of-onset effect. (cdc.gov)
Elevated body mass index, maternal age extremes and Afro-American ethnicity are associated with a higher risk of PE [ 7 ]. (hindawi.com)
People who are overweight, not active and over the age of 45 are at risk for the disease. (coastalcourier.com)
Everyone runs a risk of developing joint problems as they age, but those with a history of high heel wearing run a higher risk than most for early onset osteoarthritis in their knees. (ksl.com)
In three studies, an age-adjusted M:F relative risk (RR) given in the original publication was used instead. (bmj.com)

Did you know that Crohn's disease and ulcerative colitis are most frequently diagnosed between the ages of 15 and 30, with the typical onset being in the early 20s? (ubc.ca)

Gardasil's prevention failure erases the beneficial effects of the smear and accelerates the onset of cervical cancer. (greenmedinfo.com)

Systemic-onset JIA is characterized by spiking fevers, typically occurring once or twice each day, at about the same time of day, with temperature returning to normal or below normal. (medscape.com)
Systemic-onset JIA is usually accompanied by an evanescent rash (lasting a few hours), which is typically nonpruritic, macular, and salmon colored on the trunk and extremities. (medscape.com)
Onset is typically around the age of 5 years. (logicalimages.com)

Additional diseases including psoriasis (OR 2.43) and rheumatoid arthritis (OR 2.57) appeared at onset age 11 to 20 years. (nycu.edu.tw)
Most atopic and autoimmune diseases were observed at onset ages of 21 to 60 years. (nycu.edu.tw)
Different associated diseases in each onset age group of AA can allow clinician to efficiently investigate specific comorbidities. (nycu.edu.tw)
The terms "early-onset periodontitis" (EOP) and "juvenile periodontitis" (JP) were replaced by that of "aggressive periodontitis" (AgP) according to the classification of periodontal diseases and conditions in 1999 [24]. (bvsalud.org)

For example, we believe it misquoted some crude incidence rates as being age-adjusted (eg, the studies from Ferrara and Olmstead County). (bmj.com)

There remains a lack of clarity on the relationship between age of onset and HD progression. (tremorjournal.org)

Although the variation in age at onset is partly explained by the size of the expanded repeat, the unexplained variation in age at onset is strongly heritable (h2=0.56), which suggests that other genes modify the age at onset of HD. (healthpartners.com)

Age at onset of mental disorders worldwide: Large-scale meta-analysis of 192 epidemiological studies. (vikkisuttonpsychblog.com)

Motor and behavioral manifestations differ based on age of onset. (tremorjournal.org)

Ill persons ranged in age from 16 years to 46 years, with a median age of 25 years. (cdc.gov)

The median postnatal age at which acute retinopathy of prematurity was first seen was 51 and 40 days for those less than 28 and greater than or equal to 28 weeks' gestational age, respectively, and this difference is highly significant. (bmj.com)

Kawasaki Disease (KD) is the most common form of vasculitis in childhood that predominantly affects children under 5 years of age. (biomedcentral.com)
The age of onset of persbyopia in Burmese subjects was found to be before 35 years of age and this may be attributable to a permature sclerosis of the lens or an early development of cataract. (who.int)
All were men, two 22 and one 30 years of age. (cdc.gov)
Most affected individuals experience less severe and fewer episodes after 50 years of age. (logicalimages.com)
doctors have told us so many times he would leave the planet before he was even six years of age. (hubpages.com)
Care giving childhood, accounting for about 31% of all malignancies also involves a great deal of emotional support that may among children less than 15 years of age ( 1 ). (who.int)
They are at least 18 years of age during first round of mass vaccination. (who.int)

A total of 238 males and 166 females of ages 35 years and above were examined to determine the Visual Acuity for distance, Near Point, the cause of defective vision for cases where Visual Acuity was below 6/9, and the power of the lens to bring the Near Point to 25 cm for cases were the Near Point was over 25 cm. (who.int)

COPD and Age: What's the Relationship? (healthline.com)

Age was significantly associated with fatal treatment-related toxicity (OR 5.75, p = 0.0008). (uu.nl)
Situations that delay the onset of toxicity and aging of cholinesterase inhibitors. (cdc.gov)

Association of age with nicotine dependence was assessed by using ordered logistic regression, whereas associations with quit attempt and intention to quit were assessed by using binary logistic regressions, controlling for sociodemographic covariates and state fixed effects. (cdc.gov)

Different ages at onset resulted in disparate comorbidities. (nycu.edu.tw)

COPD occurs most often in older adults and can also affect people in their middle ages. (healthline.com)
This situation also prolongs the period when 2-PAM is effective (that period before aging occurs). (cdc.gov)

Age of onset for KD during the COVID-19 pandemic was lower and skin manifestation was higher than the same period time in last year. (biomedcentral.com)
There are so many criteria that are important which go beyond simply the number of hours of classroom time, or the age that a language is begun. (wordpress.com)
Nimodipine application, irrespective of the time of onset, did not interfere with the degeneration of microvascular pericytes. (rug.nl)
At What Age Do People Experience Depression For the First Time? (vikkisuttonpsychblog.com)
On Fridays, sleep onset was delayed, sleep time was extended and sleep quality was poorer in comparison with school nights. (eurekalert.org)
How might variation in time between onset and application help to identify potential target groups for early intervention? (ssa.gov)
This is the first time that this gene is implicated with irregular menses of reproductive age (a trait of polycystic ovarian syndrome ), hot flashes , T2D onset age , and duration years of combined oral and insulin therapy and only insulin therapies . (bvsalud.org)
The time it takes for a cholinesterase inhibitor bond to age varies. (cdc.gov)
Dr. Constance Chu, a professor of orthopedic surgery at Stanford, explained to Time.com , 'Combining walking in very high heels for long periods of time every day with obesity and aging would be a perfect storm for knee osteoarthritis. (ksl.com)
About 14,000 women responded at both time points, and of those, 914 reported that they had gone through natural menopause during that four year period, when they were between ages 40 and 65. (livescience.com)
Australia was the first country to organize routine immunization for girls (April 2007 school-based program for females aged 12-13 years, July 2007 time-limited catch-up program targeting females aged 14-26 years) and then for boys (2013). (greenmedinfo.com)

4. For each selected PCR test-positive case, we will select up to 3 test-negative controls from generally eligible subjects, matched to each case by age on the date of testing, sex, and calendar date of testing + 3 days. (who.int)

Anatomy17

Organisms12

Diseases47

Chemicals and Drugs26

Analytical, Diagnostic and Therapeutic Techniques and Equipment67

Psychiatry and Psychology26

Phenomena and Processes68

Disciplines and Occupations2

Anthropology, Education, Sociology and Social Phenomena2

Information Science10

Named Groups1

Health Care36

Geographicals3

Cardiovascular disease in insulin dependent diabetes mellitus: similar rates but different risk factors in the US compared with Europe. (1/5966)

Hereditary juvenile haemochromatosis: a genetically heterogeneous life-threatening iron-storage disease. (2/5966)

Constitutional genetic variation at the human aromatase gene (Cyp19) and breast cancer risk. (3/5966)

Cancer risk in close relatives of women with early-onset breast cancer--a population-based incidence study. (4/5966)

Age of onset in Huntington disease: sex specific influence of apolipoprotein E genotype and normal CAG repeat length. (5/5966)

Multipoint oligogenic analysis of age-at-onset data with applications to Alzheimer disease pedigrees. (6/5966)

Analysis of affected sib pairs, with covariates--with and without constraints. (7/5966)

Identification of a C/G polymorphism in the promoter region of the BRCA1 gene and its use as a marker for rapid detection of promoter deletions. (8/5966)

Time Factors

Labor Onset

Age Factors

Risk Factors

Disease Progression

Brain

Retrospective Studies

Electroencephalography

Prospective Studies

Magnetic Resonance Imaging

Acute Disease

Disease Models, Animal

Severity of Illness Index

Follow-Up Studies

Treatment Outcome

Mutation

Reaction Time

Diabetes Mellitus, Type 1

Pedigree

Pregnancy

Analysis of Variance

Case-Control Studies

Cohort Studies

Sexual Maturation

Stroke

Electromyography

Brain Ischemia

Seizures

Genotype

Genetic Predisposition to Disease

Neurons

Mice, Inbred C57BL

Longitudinal Studies

Sex Factors

Mice, Transgenic

Prognosis

Incidence

Epilepsy

Predictive Value of Tests

Infant, Newborn

Rats, Sprague-Dawley

Seasons

Photic Stimulation

Syndrome

Molecular Sequence Data

Myocardial Infarction

Circadian Rhythm

Tomography, X-Ray Computed

Action Potentials

Biological Markers

Muscle, Skeletal

Autoantibodies

Dose-Response Relationship, Drug

Alzheimer Disease

RNA, Messenger

Acoustic Stimulation

Epilepsies, Partial

Labor, Obstetric

Models, Biological

Cerebral Hemorrhage

Electric Stimulation

Epilepsy, Tonic-Clonic

Cells, Cultured

Thrombolytic Therapy

Recurrence

Gene Expression Regulation, Developmental

Alleles

Immunohistochemistry

Electrocardiography

Mice, Knockout

Family Health

Parkinson Disease

Base Sequence

Amyotrophic Lateral Sclerosis

Movement

Kinetics

Functional Laterality

Prevalence

Animals, Newborn

Body Weight