The lone species of the genus Asfivirus. It infects domestic and wild pigs, warthogs, and bushpigs. Disease is endemic in domestic swine in many African countries and Sardinia. Soft ticks of the genus Ornithodoros are also infected and act as vectors.
A sometimes fatal ASFIVIRUS infection of pigs, characterized by fever, cough, diarrhea, hemorrhagic lymph nodes, and edema of the gallbladder. It is transmitted between domestic swine by direct contact, ingestion of infected meat, or fomites, or mechanically by biting flies or soft ticks (genus Ornithodoros).
A species of the PESTIVIRUS genus causing exceedingly contagious and fatal hemorrhagic disease of swine.
A family of large icosahedral DNA viruses infecting insects and poikilothermic vertebrates. Genera include IRIDOVIRUS; RANAVIRUS; Chloriridovirus; Megalocytivirus; and Lymphocystivirus.
An acute, highly contagious disease affecting swine of all ages and caused by the CLASSICAL SWINE FEVER VIRUS. It has a sudden onset with high morbidity and mortality.
Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).
A CELL LINE derived from the kidney of the African green (vervet) monkey, (CERCOPITHECUS AETHIOPS) used primarily in virus replication studies and plaque assays.
A family of double-stranded DNA viruses containing one genus Asfivirus. It is the source of AFRICAN SWINE FEVER.
A genus of softbacked TICKS, in the family ARGASIDAE, serving as the vector of BORRELIA, causing RELAPSING FEVER, and of the AFRICAN SWINE FEVER VIRUS.
A species of CERCOPITHECUS containing three subspecies: C. tantalus, C. pygerythrus, and C. sabeus. They are found in the forests and savannah of Africa. The African green monkey (C. pygerythrus) is the natural host of SIMIAN IMMUNODEFICIENCY VIRUS and is used in AIDS research.
Viral proteins that are components of the mature assembled VIRUS PARTICLES. They may include nucleocapsid core proteins (gag proteins), enzymes packaged within the virus particle (pol proteins), and membrane components (env proteins). These do not include the proteins encoded in the VIRAL GENOME that are produced in infected cells but which are not packaged in the mature virus particle,i.e. the so called non-structural proteins (VIRAL NONSTRUCTURAL PROTEINS).
The type species of the FLAVIVIRUS genus. Principal vector transmission to humans is by AEDES spp. mosquitoes.
Proteins found in any species of virus.
A phenomenon manifested by an agent or substance adhering to or being adsorbed on the surface of a red blood cell, as tuberculin can be adsorbed on red blood cells under certain conditions. (Stedman, 25th ed)
Proteins which are synthesized as a single polymer and then cleaved into several distinct proteins.
A mosquito-borne species of the PHLEBOVIRUS genus found in eastern, central, and southern Africa, producing massive hepatitis, abortion, and death in sheep, goats, cattle, and other animals. It also has caused disease in humans.
The functional hereditary units of VIRUSES.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Viruses whose nucleic acid is DNA.
The process of intracellular viral multiplication, consisting of the synthesis of PROTEINS; NUCLEIC ACIDS; and sometimes LIPIDS, and their assembly into a new infectious particle.
A sequence of successive nucleotide triplets that are read as CODONS specifying AMINO ACIDS and begin with an INITIATOR CODON and end with a stop codon (CODON, TERMINATOR).
The assembly of VIRAL STRUCTURAL PROTEINS and nucleic acid (VIRAL DNA or VIRAL RNA) to form a VIRUS PARTICLE.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
A species of SWINE, in the family Suidae, comprising a number of subspecies including the domestic pig Sus scrofa domestica.
Deoxyribonucleic acid that makes up the genetic material of viruses.
The degree of pathogenicity within a group or species of microorganisms or viruses as indicated by case fatality rates and/or the ability of the organism to invade the tissues of the host. The pathogenic capacity of an organism is determined by its VIRULENCE FACTORS.
Diseases of domestic swine and of the wild boar of the genus Sus.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
Blood-sucking acarid parasites of the order Ixodida comprising two families: the softbacked ticks (ARGASIDAE) and hardbacked ticks (IXODIDAE). Ticks are larger than their relatives, the MITES. They penetrate the skin of their host by means of highly specialized, hooked mouth parts and feed on its blood. Ticks attack all groups of terrestrial vertebrates. In humans they are responsible for many TICK-BORNE DISEASES, including the transmission of ROCKY MOUNTAIN SPOTTED FEVER; TULAREMIA; BABESIOSIS; AFRICAN SWINE FEVER; and RELAPSING FEVER. (From Barnes, Invertebrate Zoology, 5th ed, pp543-44)
The infective system of a virus, composed of the viral genome, a protein core, and a protein coat called a capsid, which may be naked or enclosed in a lipoprotein envelope called the peplos.
An abnormal elevation of body temperature, usually as a result of a pathologic process.
A species of NAIROVIRUS of the family BUNYAVIRIDAE. It is primarily transmitted by ticks and causes a severe, often fatal disease in humans.
Visible morphologic changes in cells infected with viruses. It includes shutdown of cellular RNA and protein synthesis, cell fusion, release of lysosomal enzymes, changes in cell membrane permeability, diffuse changes in intracellular structures, presence of viral inclusion bodies, and chromosomal aberrations. It excludes malignant transformation, which is CELL TRANSFORMATION, VIRAL. Viral cytopathogenic effects provide a valuable method for identifying and classifying the infecting viruses.
Immunoglobulins produced in response to VIRAL ANTIGENS.
An acute infectious disease primarily of the tropics, caused by a virus and transmitted to man by mosquitoes of the genera Aedes and Haemagogus. The severe form is characterized by fever, HEMOLYTIC JAUNDICE, and renal damage.
The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)
Established cell cultures that have the potential to propagate indefinitely.
An acute infection caused by the RIFT VALLEY FEVER VIRUS, an RNA arthropod-borne virus, affecting domestic animals and humans. In animals, symptoms include HEPATITIS; abortion (ABORTION, VETERINARY); and DEATH. In humans, symptoms range from those of a flu-like disease to hemorrhagic fever, ENCEPHALITIS, or BLINDNESS.
A republic in southern Africa east of ZAMBIA and MOZAMBIQUE. Its capital is Lilongwe. It was formerly called Nyasaland.
The complete genetic complement contained in a DNA or RNA molecule in a virus.
The type species of ORTHOPOXVIRUS, related to COWPOX VIRUS, but whose true origin is unknown. It has been used as a live vaccine against SMALLPOX. It is also used as a vector for inserting foreign DNA into animals. Rabbitpox virus is a subspecies of VACCINIA VIRUS.
A genus of FLAVIVIRIDAE, also known as mucosal disease virus group, which is not arthropod-borne. Transmission is by direct and indirect contact, and by transplacental and congenital transmission. Species include BORDER DISEASE VIRUS, bovine viral diarrhea virus (DIARRHEA VIRUS, BOVINE VIRAL), and CLASSICAL SWINE FEVER VIRUS.
The degree of similarity between sequences of amino acids. This information is useful for the analyzing genetic relatedness of proteins and species.
The outer protein protective shell of a virus, which protects the viral nucleic acid.
A genus of IRIDOVIRIDAE comprising small iridescent insect viruses. The infected larvae and purified virus pellets exhibit a blue to purple iridescence.

A lipid modified ubiquitin is packaged into particles of several enveloped viruses. (1/269)

An anti-ubiquitin cross-reactive protein which migrates more slowly (6.5 kDa) by SDS-PAGE than ubiquitin was identified in African swine fever virus particles. This protein was extracted into the detergent phase in Triton X-114 phase separations, showing that it is hydrophobic, and was radiolabelled with both [3H]palmitic acid and [32P]orthophosphate. This indicates that the protein has a similar structure to the membrane associated phosphatidyl ubiquitin described in baculovirus particles. A similar molecule was found in vaccinia virus and herpes simplex virus particles, suggesting that it may be a component of uninfected cell membranes, which is incorporated into membrane layers in virions during morphogenesis.  (+info)

Nuclear and nucleolar localization of an African swine fever virus protein, I14L, that is similar to the herpes simplex virus-encoded virulence factor ICP34.5. (2/269)

PCR analysis of the genomes of 18 different African swine fever virus (ASFV) isolates showed that the I14L open reading frame (ORF) was present as either a long form or short form in all of the isolates. Sequencing of the ORF from eight isolates confirmed that both forms of the ORF were well conserved. Antisera raised against the I14L protein identified the long form of the protein as a 21 kDa protein expressed late during ASFV infection. Immunofluorescent analysis of transiently expressed haemagglutinin-tagged forms of the I14L protein showed that the long form of the protein localized predominantly to the nucleus and within the nucleoli. In contrast, although the short form of the protein was also present predominantly in the nucleus, it did not localize to the nucleoli. Deletion of the N-terminal 14 amino acids from the long form of the I14L protein, which includes a high proportion of basic Arg/Lys residues, abolished the specific nucleolar localization of the protein, although the protein was still present in the nucleus. Addition of this 14 amino acid sequence to beta-galactosidase or replacement of the N-terminal 14 amino acids of the I14L short form with those from the long form directed both of these modified proteins to the nucleolus. This indicates that this 14 amino acid sequence contains all the signals required for nucleolar localization.  (+info)

Modulation of monocytic cell activity and virus susceptibility during differentiation into macrophages. (3/269)

A major component of innate immune responses relies on monocytes and macrophages, virus infection of which will pose a particular problem for immunological defense. Consequently, the monocytic cell differentiation pathway was analyzed in terms of cellular modulations therein and their relation to monocytotropic virus infection. Differentiation was characterized by down-regulation of CD14, MHC Ags, the monocytic SWC1 marker, and p53; concomitant up-regulation of the SWC9 macrophage marker, a putative porcine CD80 (detected with anti-human CD80 Ab), and acid phosphatase secretion were also characteristic. Elevated phagocytic and endocytic activities as well as endosomal/lysosomal acidification were identified as being important to the macrophage. In contrast, monocytes possessed high accessory activity. This was multifactorial, concomitantly requiring 1) high MHC Ag expression; 2) enzyme activity of esterase, peroxidase, myeloperoxidase, and 5' nucleotidase in preference to glucosidase, galactosidase, and glucuronidase; and 3) elevated capacity for spontaneous IL-1 production. Only with all parameters was efficient stimulation of Ag-specific lymphocytes possible. These results point to a continuous process during differentiation, involving inter-related characteristics linking the more accessory monocyte to the scavenger macrophage, both in vitro and in vivo. Of particular interest was how these characteristics related to monocytotropic virus infection, and how a particular virus could show a clear preference for the differentiating macrophages. Such results not only further our understanding of porcine immunology, but also provide evidence and a potential model for the determination and characterization of monocytotropic virus-host cell interactions.  (+info)

The biological effects induced in mice by p36, a proteinaceous factor of virulence produced by African swine fever virus, are mediated by interleukin-4 and also to a lesser extent by interleukin-10. (4/269)

We have previously presented indirect evidence that both specific immunosuppression and lymphocyte mitogenicity induced in mice by p36, a proteinaceous factor of virulence produced by porcine monocytes infected by African swine fever virus, were consistent with a Th2-driven response. Here we show: (1) Interleukin-4 (IL-4) and interleukin-10 (IL-10) mRNA expression in the spleen and thymus of C57BL/6 mice were displayed early after p36 inoculation. The expression of thymic IL-10 mRNA occurred, however, later than that of IL-4 mRNA. (2) Increased serum levels of these two cytokines were also soon detected after the protein inoculation. (3) Both immunosuppressive and mitogenic effects of p36 were absent in IL-4 gene-targeted mice and partially abrogated in mice depleted of IL-4 by neutralizing monoclonal antibodies. (4) IL-10 depletion abrogated the immunosuppressive but not the p36 lymphocyte mitogenic biological effects. (5) The increase in the serum concentrations of both IL-4 and IL-10 were lower in thymectomized than in non-thymectomized mice. (6) The expression of interferon-gamma (IFN-gamma) mRNA was weakly or not at all induced in p36-treated mice. Taken together, these results are in agreement with the promotion of a Th2 immune response induced by p36.  (+info)

Replication of African swine fever virus DNA in infected cells. (5/269)

We have examined the ultrastructural localization of African swine fever virus DNA in thin-sections of infected cells by in situ hybridization and autoradiography. Virus-specific DNA sequences were found in the nucleus of infected Vero cells at early times in the synthesis of the viral DNA, forming dense foci localized in proximity to the nuclear membrane. At later times, the viral DNA was found exclusively in the cytoplasm. Electron microscopic autoradiography of African swine fever virus-infected macrophages showed that the nucleus is also a site of viral DNA replication at early times. These results provide further evidence of the existence of nuclear and cytoplasmic stages in the synthesis of African swine fever virus DNA. On the other hand, alkaline sucrose sedimentation analysis of the replicative intermediates synthesized in the nucleus and cytoplasm of infected macrophages showed that small DNA fragments ( approximately 6-12S) were synthesized in the nucleus at an early time, whereas at later times, larger fragments of approximately 37-49S were labeled in the cytoplasm. Pulse-chase experiments demonstrated that these fragments are precursors of the mature cross-linked viral DNA. The formation of dimeric concatemers, which are predominantly head-to-head linked, was observed by pulsed-field electrophoresis and restriction enzyme analysis at intermediate and late times in the replication of African swine fever virus DNA. Our findings suggest that the replication of African swine fever virus DNA proceeds by a de novo start mechanism with the synthesis of small DNA fragments, which are then converted into larger size molecules. Ligation or further elongation of these molecules would originate a two-unit concatemer with dimeric ends that could be resolved to generate the genomic DNA by site-specific nicking, rearrangement, and ligation as has been proposed in the de novo start model of Baroudy et al. (B. M. Baroudy, S. Venkatesam, and B. Moss, 1982, Cold Spring Harbor Symp. Quant. Biol. 47, 723-729) for the replication of vaccinia virus DNA.  (+info)

The African swine fever virus prenyltransferase is an integral membrane trans-geranylgeranyl-diphosphate synthase. (6/269)

In a previous study, it was shown that the protein encoded by the gene B318L of African swine fever virus (ASFV) is a trans-prenyltransferase that catalyzes in vitro the condensation of farnesyl diphosphate and isopentenyl diphosphate to synthesize geranylgeranyl diphosphate and longer chain prenyl diphosphates (Alejo, A., Yanez, R. J., Rodriguez, J. M., Vinuela, E., and Salas, M. L. (1997) J. Biol. Chem. 272, 9417-9423). To investigate the in vivo function of the viral enzyme, we have determined, in this work, its subcellular localization and activity in cell extracts. Two systems were used in these studies: cells infected with ASFV and cells infected with a recombinant pseudo-Sindbis virus carrying the complete B318L gene. In this latter system, the trans-prenyltransferase was found to colocalize with the endoplasmic reticulum marker protein-disulfide isomerase, whereas in cells infected with ASFV, the viral enzyme was present in cytoplasmic viral assembly sites, associated with precursor viral membranes derived from the endoplasmic reticulum. In addition, after subcellular fractionation, the viral enzyme partitioned into the membrane fraction. Extraction of membrane proteins with alkaline carbonate and Triton X-114 indicated that the ASFV enzyme behaved as an integral membrane protein. The membrane enzyme synthesized predominantly all-trans-geranylgeranyl diphosphate from farnesyl diphosphate and isopentenyl diphosphate. These results indicate that the viral B318L protein is a trans-geranylgeranyl-diphosphate synthase, being the only enzyme of this type that is known to have a membrane localization.  (+info)

African swine fever virus: a B cell-mitogenic virus in vivo and in vitro. (7/269)

The two major characteristics of pathogenesis in African swine fever virus (ASFV) infections of domestic pigs are massive B-cell apoptosis and haemorrhage. The effects of ASFV on porcine B cells have therefore been systematically examined in vivo, by using virus-infected pigs and SCID-Beige mice reconstituted with porcine bone marrow, and in vitro, by using porcine B-cell lines and B cells from normal and ASFV-infected pigs. Secretion of porcine Ig was stimulated by ASFV both in vivo and in bone marrow cultures in vitro, with the virulent Malawi isolate of ASFV being the most effective. Stimulation of Ig secretion in vitro depended on the presence of ASFV-infected macrophages and did not occur with supernatants from ASFV-infected macrophages. Although the virus alone did not stimulate proliferation of purified B cells in vitro, it was co-stimulatory with CD154 (CD40 ligand). The B cells recovered from ASFV-infected porcine lymphoid tissue were of activated surface marker phenotypes and, interestingly, expressed diminished levels of the B-cell co-stimulatory surface molecule CD21. In addition, they were highly sensitive to IL-4 and CD154. These results may be integrated into a model of pathogenesis in which those B cells activated indirectly as a result of virulent ASFV infection of macrophages are not rescued from apoptosis through interaction with CD154, due to the drastic depletion of T cells that occurs early in infection. The consequently diminished specific anti-ASFV antibody response would favour survival of the virus, with the non-specific hypergammaglobulinaemia being perhaps another example of pathogen-mediated immune deviation.  (+info)

African swine fever virus replication in the midgut epithelium is required for infection of Ornithodoros ticks. (8/269)

Although the Malawi Lil20/1 (MAL) strain of African swine fever virus (ASFV) was isolated from Ornithodoros sp. ticks, our attempts to experimentally infect ticks by feeding them this strain failed. Ten different collections of Ornithodorus porcinus porcinus ticks and one collection of O. porcinus domesticus ticks were orally exposed to a high titer of MAL. At 3 weeks postinoculation (p.i.), <25% of the ticks contained detectable virus, with viral titers of <4 log(10) 50% hemadsorbing doses/ml. Viral titers declined to undetectability in >90% of the ticks by 5 weeks p.i. To further study the growth defect, O. porcinus porcinus ticks were orally exposed to MAL and assayed at regular intervals p.i. Whole-tick viral titers dramatically declined (>1,000-fold) between 2 and 6 days p.i., and by 18 days p.i., viral titers were below the detection limit. In contrast, viral titers of ticks orally exposed to a tick-competent ASFV isolate, Pretoriuskop/96/4/1 (Pr4), increased 10-fold by 10 days p.i. and 50-fold by 14 days p.i. Early viral gene expression, but not extensive late gene expression or viral DNA synthesis, was detected in the midguts of ticks orally exposed to MAL. Ultrastructural analysis demonstrated that progeny virus was rarely present in ticks orally exposed to MAL and, when present, was associated with extensive cytopathology of phagocytic midgut epithelial cells. To determine if viral replication was restricted only in the midgut epithelium, parenteral inoculations into the hemocoel were performed. With inoculation by this route, a persistent infection was established although a delay in generalization of MAL was detected and viral titers in most tissues were typically 10- to 1,000-fold lower than those of ticks injected with Pr4. MAL was detected in both the salivary secretion and coxal fluid following feeding but less frequently and at a lower titer compared to Pr4. Transovarial transmission of MAL was not detected after two gonotrophic cycles. Ultrastructural analysis demonstrated that, when injected, MAL replicated in a number of cell types but failed to replicate in midgut epithelial cells. In contrast, ticks injected with Pr4 had replicating virus in midgut epithelial cells. Together, these results indicate that MAL replication is restricted in midgut epithelial cells. This finding demonstrates the importance of viral replication in the midgut for successful ASFV infection of the arthropod host.  (+info)

Modulation of the structure, catalytic activity, and fidelity of African swine fever virus DNA polymerase X by a reversible disulfide switch.
African swine fever virus, illustration. This virus is a member of the iridovirus group that causes African swine fever. Unlike other DNA- containing vertebrate viruses (except the poxviruses), the iridovirus replicates in the host cells cytoplasm (most others replicate in the nucleus). - Stock Image F016/8841
African swine fever is a devastating hemorrhagic fever of pigs, caused by the African swine fever virus (ASFV). In Africa, the presence of a sylvatic cycle involving warthogs and soft ticks means that the risk of introduction of ASFV into domestic swine is always present. Bushpigs (Potamochoerus larvatus) are nocturnal, susceptible to ASFV and share a natural interface with both warthogs and domestic pigs. The role of the bushpig in the epidemiology of ASFV if any is not understood, yet control strategies of the disease in areas with probable contact between bushpigs and domestic pigs would depend on such information. This study used a molecular and ecological approach to investigate the role of the bushpig in the epidemiology of African swine fever at the wildlife-livestock interface in Uganda. The GPS/GSM tracking collars were used to monitor the movement patterns of free-ranging domestic pigs and bushpigs. Four free-ranging domestic pigs and five bushpigs were collared and their movements ...
The role of the ancestral sylvatic cycle of the African swine fever virus (ASFV) is not well understood in the endemic areas of eastern Africa. We therefore analysed the ASF infection status on samples collected from 51 free-ranging warthogs (Phacocherus africanus) and 1576 Ornithodorus porcinus ticks from 26 independent warthog burrows at a single ranch in Kenya. Abattoir samples from 83 domestic pigs without clinical symptoms, originating from specific locations with no recent reported ASF outbreaks were included in this study. All samples were derived from areas of central Kenya, where ASF outbreaks have been reported in the past. Infection with ASFV was confirmed in 22% of O. porcinus pools, 3.22% of adult warthog serum samples and 49% of domestic pig serum samples by using p72-based PCR. All of the warthog sera were positive for anti-ASFV antibodies, investigated by using ELISA, but none of the domestic pig sera were positive. Twenty O. porcinus-, 12 domestic pig- and three warthogderived ...
Rigid amphipathic fusion inhibitors (RAFIs) are a family of nucleoside derivatives that inhibit the infectivity of several enveloped viruses by interacting with virion envelope lipids and inhibiting fusion between viral and cellular membranes. Here we tested the antiviral activity of two RAFIs, 5-(Perylen-3-ylethynyl)-arabino-uridine (aUY11) and 5-(Perylen-3-ylethynyl)uracil-1-acetic acid (cm1UY11) against African swine fever virus (ASFV), for which no effective vaccine is available. Both compounds displayed a potent, dose-dependent inhibitory effect on ASFV infection in Vero cells. The major antiviral effect was observed when aUY11 and cm1UY11 were added at early stages of infection and maintained during the complete viral cycle. Furthermore, virucidal assay revealed a significant extracellular anti-ASFV activity for both compounds. We also found decrease in the synthesis of early and late viral proteins in Vero cells treated with cm1UY11. Finally, the inhibitory effect of aUY11 and cm1UY11 on ASFV
African swine fever. African swine fever (ASF) is a highly contagious hemorrhagic disease of pigs that produces a wide range of clinical signs and lesions that closely resemble those of classical swine fever. Infection, with a highly variable virulence, causes, typically 3-15 days later, high fever, reddening of the skin (visible only in pale-skinned pigs), decreased appetite, listlessness, loss of coordination, vomiting, diarrhoea (sometimes bloody) and eye discharges. Mortality rates can be as high as 100% in domestic pigs and wild boar, with death occurring in less than a week. In some cases, sudden death may be the only clinical sign.. The disease was first described after European settlers brought pigs into areas endemic with ASFV and, as such, is an example of an emerging infection. Although ASFV can be adapted to grow in cells from different species, it does not replicate readily in any species other than swine. Fortunately, African swine fever is not a human health threat.. The virus : ...
We describe a horizontal survey of African swine fever virus (ASFV) prevalence and risk factors associated with virus infection in domestic pigs in two contrasting production systems in Kenya. A free range/tethering, low input production system in Ndhiwa District of South-western Kenya is compared with a medium input stall fed production system in Kiambu District of Central Kenya. Analysis of variance (ANOVA) of data derived from cluster analysis showed that number of animals, number of breeding sows and number of weaner pigs were a significant factor in classifying farms in Nhiwa and Kiambu. Analysis of blood and serum samples using a PCR assay demonstrated an average animal level positivity to ASFV of 28% in two independent samplings in South-western Kenya and 0% PCR positivity in Central Kenya. No animals were sero-positive in either study site using the OIE indirect-ELISA and none of the animals sampled exhibited clinical symptoms of ASF. The farms that contained ASFV positive pigs in Ndhiwa ...
The African swine fever virus (ASFV) DP71L protein is present in all isolates as either a short form of 70 to 72 amino acids or a long form of about 184 amino acids, and both of these share sequence similarity to the C-terminal domain of the herpes simplex virus ICP34.5 protein and cellular protein GADD34.
Jouvenet, Nolween, Windsor, Miriam, Rietdorf, Jens, Hawes, Pippa, Monaghan, Paul, Way, Michael and Wileman, Thomas (2006) Induction of filopodia at the plasma membrane by African Swine Fever virus. Cellular Microbiology, 8 (11). pp. 1803-1811. ISSN 1462-5822 Full text not available from this repository. (Request a copy ...
Read Molecular epidemiology of African swine fever virus studied by analysis of four variable genome regions, Archives of Virology on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
Read Commercially Available Cell Line Rapidly Detects African Swine Fever Virus in addition to hundreds of recent farming and agriculture news articles. View up to date crop reports, livestock information and ag industry breaking news from farms.com.
African swine fever is highly contagious and nearly 100% fatal to swine herds. It occurs among pigs and wild boars, transmitted by ticks and direct contact between animals. There is no vaccine for the disease, but it does not affect humans.. The first outbreak of African swine fever in East Asia was reported in China in early August 2018. Since then, the deadly virus has spread to all Chinese provinces and regions, as well as to other Asian nations, including Vietnam and the Philippines.. South Korea, Asias fourth-largest economy, does not import any pork products or live pigs from China due to Chinas history of foot-and-mouth disease outbreaks. It mainly imports from the United States and Germany, and pork imports account for about a third of the countrys total pork supplies.. Although this is the first time African swine fever has hit South Korea, an incidence of foot-and-mouth disease was confirmed in March 2018 at a hog farm, the countrys first discovery since February 2017.. South Korea ...
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Gene editing of large DNA viruses, such as African swine fever virus (ASFV), has traditionally relied on homologous recombination of a donor plasmid consisting of a reporter cassette with surrounding homologous viral DNA. However, this homologous recombination resulting in the desired modified virus is a rare event. We recently reported the use of CRISPR/Cas9 to edit ASFV. The use of CRISPR/Cas9 to modify the African swine fever virus genome resulted in a fast and relatively easy way to introduce genetic changes. To accomplish this goal we first infect primary swine macrophages with a field isolate, ASFV-G, and transfect with the CRISPR/Cas9 donor plasmid along with a plasmid that will express a specific gRNA that targets our gene to be deleted. By inserting a reporter cassette, we are then able to purify our recombinant virus from the parental by limiting dilution and plaque purification. We previously reported comparing the traditional homologous recombination methodology with CRISPR/Cas9, which
BEIJING, Oct. 18 (Xinhua) -- Chinese scientists have unraveled the three-dimensional structure of the African swine fever virus, laying a solid foundation for developing effective and safe vaccines against the disease.. The research, jointly conducted by scientists at the Institute of Biophysics of the Chinese Academy of Sciences (CAS) and the Harbin Veterinary Research Institute of the Chinese Academy of Agricultural Sciences (CAAS), ShanghaiTech University and other institutes, was published in the latest issue of the academic journal Science.. Bu Zhigao, director of the Harbin Veterinary Research Institute of CAAS, said China is facing a great challenge in controlling the spread of African swine fever. It is urgent to develop more powerful tools such as a vaccine to prevent the disease.. The breakthrough in unveiling the fine structure of the virus is important and fundamental research, which will provide clues to explore fundamental mechanisms for the infection, pathogenicity and immunology ...
We applied social network analysis to pig trader networks on the Kenya-Uganda border. Social network analysis is a recently developed tool, which is useful for understanding value chains and improving disease control policies. We interviewed a sample of 33 traders about their experiences with trade and African swine fever (ASF), analyzed the networks they generated in purchasing pigs and selling pork and their potential contribution to modulating dissemination of the ASF virus (ASFV). The majority of the traders were aware of clinical signs of ASF and the risk of trade transmitting ASFV. Most said they avoided buying pigs from ASF outbreak villages or sick pigs but their experiences also indicated that inadvertent purchase was relatively common. Traders had early knowledge of outbreaks since they were contacted by farmers who had heard rumours and wanted to sell their pigs to avoid the risk of them dying. Individual traders bought pigs in up to nine villages, and up to six traders operated in a ...
The World Organization for Animal Health, or OIE, and the Food and Agriculture Organization, or FAO, have called on countries and partners to join forces against African swine fever, which has become a major crisis for the pork industry.. The organizations said the fever is causing massive losses in pig populations and generating drastic economic consequences. Pork is the most consumed meat in the world, representing 36 percent of global meat consumption.. On a global scale, they said the sustained spread of the fever poses a threat to food security, economic and rural development.. The organizations said the disease represents a barrier to the agricultural sector to reach its full potential, generate employment and alleviate poverty, and acts as a disincentive to investment in the sector.. Global control of African swine fever will thus contribute to achieving the United Nations Sustainable Development Goals, notably goal one which seeks to alleviate poverty and goal two that seeks achievement ...
The Bulgarian Food Safety Agency said that it had on January 8 confirmed four new outbreaks of African Swine Fever, one at an industrial farm in the Black Sea district of Varna where there were close to 40 000 pigs.. The outbreaks were confirmed by laboratory tests, the agency said.. The industrial farm where the outbreak was confirmed was in the village of Brestak, in the Vulchi Dol municipality in Varna.. The agency said that some of the pigs at the industrial farm in the village of Nikola Kozlevo, where an outbreak of African Swine Fever was confirmed a few days ago - leading to an order to cull 24 500 pigs, had come from Brestak.. A three-kilometre protection zone has been declared, which includes the villages of Brestak and General Kiselovo. A 10km monitoring zone also has been declared.. A new outbreak was registered at an Eastern Balkan pig breeding farm in the village of Vesselinovo, in the Smyadovo municipality in the district of Shoumen. A total of 125 pigs are on the premises. A three ...
African swine fever does not affect humans and is not a public health threat. Pork products from animals with African swine fever are safe to eat.
Microarray technology can be useful for pathogen detection as it allows simultaneous interrogation of the presence or absence of a large number of genetic signatures. However, most microarray assays are labour-intensive and time-consuming to perform. This study describes the development and initial evaluation of a multiplex reverse transcription (RT)-PCR and novel accompanying automated electronic microarray assay for simultaneous detection and differentiation of seven important viruses that affect swine (foot-and-mouth disease virus [FMDV], swine vesicular disease virus [SVDV], vesicular exanthema of swine virus [VESV], African swine fever virus [ASFV], classical swine fever virus [CSFV], porcine respiratory and reproductive syndrome virus [PRRSV] and porcine circovirus type 2 [PCV2 ...
Industry insiders tell Reuters that a new form of African swine fever is popping up on Chinese pig farms. The timing is not good for the worlds biggest pork producer thats still trying to recover from a devastating epidemic.. Two new strains of African Swine Fever have infected over 1,000 sows on several farms owned by Chinas fourth-largest pork producer. Its also showing up in pigs being fattened for the firm by contract farmers.. A company spokesperson says the disease isnt quite the same as the wild African Swine Fever Virus because the new variant doesnt kill the large number of pigs that China lost in 2018 and 2019. The new strain causes a chronic condition that reduces the number of healthy piglets born to sows. But infected pigs are culled from herds to prevent the spread, which makes the disease ultimately fatal.. Many Chinese farmers turned to unapproved products to help protect their animals. Chinese experts fear the illicit vaccines created accidental infections that have begun ...
The Mkuze Game Reserve (MGR), in north-eastern KwaZulu-Natal Province, South Africa is an African swine fever virus (ASF) controlled area. In a survey conducted in 1978, ASF prevalence in warthogs and Ornithodoros ticks in MGR was determined to be 2% and 0.06%, respectively. These values, acknowledged as being unusually low compared to other East and southern African ASF-positive sylvatic-cycle host populations, have not been assessed since. The availability of a sensitive PCR-based virus detection method, developed specifically for the sylvatic tampan host, prompted a re-evaluation of ASF virus (ASFV) prevalence in MGR ticks. Of the 98 warthog burrows inspected for Ornithodoros presence, 59 (60.2%) were found to contain tampans and tick sampling was significantly male-biased. Whilst gender sampling-bias is not unusual, the 27% increase in infestation rate of warthog burrows since the 1978 survey is noteworthy as it anticipates a concomitant increase in ASFV prevalence, particularly in light of the high
Bushpigs and warthogs are natural reservoir hosts of African swine fever virus (ASFV) in the wild, showing no clinical signs of disease when infected with the same highly virulent isolates of ASFV that induce rapid, haemorrhagic death in domestic pigs. In contrast to domestic pigs, infection of bushpigs with Malawi isolate results in low levels of virus replication and lymphocyte apoptosis within the spleen, and a relatively low spread of virus to other lymphoid tissues. However, at 10 days post-infection, a high degree of apoptosis was seen in B lymphocytes of the B cell follicles in bushpig lymph nodes. Virus infected cells were present amongst the apoptotic B cells of these follicles, suggesting that indirect factors released from ASFV infected macrophages signal surrounding lymphocytes to enter apoptosis. The susceptibility/resistance of domestic pigs/bushpigs to ASFV may serve as a unique veterinary model for the recently emerging haemorrhagic disease of man.
MatMaCorp announced today the successful evaluation of a genetic test to detect African swine fever virus in uncooked pork products.
African swine fever has ravaged Chinas pig population, and the countrys consumers are feeling the pain. Some are even switching to other meats as the dietary staple becomes unaffordable.
Michael S Denyer and Philip J Wilkinson, Institute for Animal Health, Pirbright Laboratory, Pirbright, UK. African swine fever (ASF) is a highly contagious acute hemorrhagic disease of domestic pigs caused by a large icosahedral DNA virus which produces a wide range of clinical signs. Protective immunity can be stimulated in vivo but classical neutralizing antibodies have not been demonstrated. The complete genome has been sequenced and some proteins that could enable the virus to evade the host immune response have been identified. There is no vaccine.. ...
by Stephen Wagner. The National Pork Producers Councils board of directors has announced its decision to cancel the 2019 World Pork Expo in Iowa out of an abundance of caution as African swine fever (ASF) continues to spread in China and other parts of Asia. The World Pork Expo, held each June at the Iowa State Fairgrounds in Des Moines, hosts approximately 20,000 visitors over three days, including individuals and exhibitors from ASF-positive regions. ASF affects only pigs and presents no human health or food safety risks. There is currently no vaccine to treat the swine disease.. The above paragraph came from a recent press release issued by the NPPC, and was forwarded to me by Penn-Ag Industries Assistant Vice President Jessica Darr. While attending Penn-Ags annual meeting, Darr, and Debbie Reed-Harry, casually mentioned ASF, something I was hearing about for the first time. How serious is this? I asked.. We talk about it every day, Darr said.. When I got home I began a file on it, and ...
May 2, 2019 - Ottawa, Ontario, Canada - The Animal and Plant Health Inspection Services Chief Veterinary Officer for the United States, Dr. Jack Shere, accompanied by Dr. Jaspinder Komal, Chief Veterinary Officer for Canada and by Dr. Juan Gay Gutierrez, Chief Veterinary Officer for Mexico issued the following statement about the African swine fever (ASF) forum that took place in Ottawa, Ontario, Canada on April 30 and May 1: Over the course of the last two days, we have worked with colleagues from around the globe at the Forum to address the risk of ASF, a serious animal disease currently impacting swine herds in Europe and Asia.. I would like to thank the over 150 leaders and decision makers from government and industry from 15 countries who shared their expertise, engaged in productive discussions, and contributed to developing strategies to address ASF. Jointly, we have developed a framework that will support ongoing international collaboration and action in the areas of preparedness ...
African swine fever (ASF) is a highly contagious and deadly viral disease that can impact domestic and wild pigs. It is not a human pathogen, but ASF can be devastating to the health of swine and cause significant economic and production losses to farmers and pork processors.
African swine fever (ASF) is a highly contagious and deadly viral disease that can impact domestic and wild pigs. It is not a human pathogen, but ASF can be devastating to the health of swine and cause significant economic and production losses to farmers and pork processors.
AFRICA - The Food and Agriculture Organization of the United Nations (FAO) has joined with two African organisations to develop a regional strategy for the control of African swine fever (ASF) for the continent.
To assist with the departments response to African swine fever (ASF) the detector dog, Suki, currently deployed on Norfolk Island has been redeployed to Darwin. Australia is facing an increasing threat of ASF, a highly contagious viral disease of pigs with no vaccine currently available. ASF is spreading rapidly overseas with significant pig losses being experienced in infected countries. The department is boosting biosecurity effort at international airports to target flights from countries affected by ASF, with detector dogs playing an important role.
Laos has reported to the World Organization for Animal Health (OIE) a series of seven cases of African swine fever (ASF) in the southern portion of the Southeast Asian country.. Read more ...
Abstract: A training and outreach program to increase public awareness of African swine fever (ASF) was implemented by DTRA and the Ministries of Agriculture in Armenia, Georgia, Kazakhstan, and Ukraine. The implementing agency was the company SAFOSO (Switzerland). Integration of this regional effort was administered by subject matter experts for each country. The main teaching effort of this project was to develop a comprehensive regional public outreach campaign through a network of expertise and knowledge for the control and prevention of ASF in four neighboring countries that experience similar issues with this disease. Gaps in disease knowledge, legislation, and outbreak preparedness in each country were all addressed. Because ASF is a pathogen with bioterrorism potential and of great veterinary health importance that is responsible for major economic instability, the project team developed public outreach programs to train veterinarians in the partner countries to accurately and rapidly
Pork is the primary meat in China, which means African swine fever, sometimes dubbed ASF, has the potential to undermine the countrys food industry and affect global food supplies. There is no vaccine. At the beginning of this month, the virus was detected in the village of Guanfang, in the southwestern province of Yunnan, less than 200 km from Myanmar and Laos.. [Just recently], Thailands Department of Livestock Development reported that ASF had been detected in sausages that Chinese tourists had brought with them on a flight from the city of Chengdu to Chiang Rai, according to Thai media reports. Chiang Rai is located in the north of Thailand, near Myanmar and Laos. The department in September banned the import of pigs and pork products, stationing personnel at borders and in airports to enforce a quarantine, according to earlier news reports.. JeerasakPipattanapongsophon, Deputy Director-General of Thailands Department of Livestock Development, last month admitted the situation is grim. ...
Davao del Norte: Authorities have put Barangay Cagangohan in Panabo City on lockdown after 12 confirmed cases of the African Swine Fever (ASF) in the area.. Governor Edwin Jubahib said stricter quarantine protocol is necessary to prevent the spread of the killer hog disease to other parts of the province.. We now blocked the entry and exit of live pig and pork products to and from Caganguhan to stop the spread of the disease, the governor explained to the residents during his visit to the area on Wednesday.. The Governor discussed strict quarantine procedures with village officials and residents, together with DA-XI Regional Director Ricardo Onate, Jr., Mayor Jose Relampagos and officials from the police and the military.. Jubahib ordered the immediate culling of all pigs in the area, as he vowed financial assistance to hog raisers.. The DA and provincial and city governments chipped in to raise the indemnification to ₱2,000 per suckling and ₱8,000 per hog. While the virus has no effect on ...
Municipal Mayor Darwin R. Manalansan together with Honorable Vice-Mayor Michael L. Galang, Task Force ASF and different Barangay Captains of this Municipality, currently enjoined meeting to discuss matters to be raised to combat the clamor that may be brought about by the current situation pertaining to the African Swine Fever (ASF) in the Province of Pampanga.. #bwg_container1_0 #bwg_container2_0 .bwg-container-0.bwg-standard-thumbnails { width: 1254px; justify-content: center; margin:0 auto !important; background-color: rgba(255, 255, 255, 0.00); padding-left: 4px; padding-top: 4px; max-width: 100%; } #bwg_container1_0 #bwg_container2_0 .bwg-container-0.bwg-standard-thumbnails .bwg-item { justify-content: flex-start; max-width: 250px; } #bwg_container1_0 #bwg_container2_0 .bwg-container-0.bwg-standard-thumbnails .bwg-item > a { margin-right: 4px; margin-bottom: 4px; } #bwg_container1_0 #bwg_container2_0 .bwg-container-0.bwg-standard-thumbnails .bwg-item0 { padding: 0px; ...
African Swine Fever (ASF) continues to spread across Russia. Over the last week two major outbreaks were registered in the Volgograd region.
Three new outbreaks of African Swine Fever (ASF) have been detected in the Russian Tver region, reports the Rosselkhoznadzor, the Federal Service for Veterinary and Phytosanitary Surveillance. All of them occurred in wild boars, in different parts of the region.
African Swine Fever (ASF) has broken out in China, in what has been described as considered one of the largest animal disorder outbreaks ever seen. The
Keeping African swine fever (ASF) out of Britain is a top priority for the pig sector and a Bpex poster is aimed at helping farmers remind their eastern Eu
Source: Feedstuffs. Following reports that neighboring Vietnam has culled more than 2.5 million hogs since February, Laos has reported to the World Organization for Animal Health (OIE) a series of seven cases of African swine fever (ASF) in the southern portion of the Southeast Asian country. ...
African swine fever (ASF), first detected in Germany in a wild boar on 10 September 2020, does not pose a health hazard to humans.
Zeerust in the North West has reportedly been hit by an African Swine Fever ASF outbreakIt was reported to the World Organisation for Animal Health OIE
Nearly 800 wild boar carcasses infected with African swine fever (ASF) have been found in Estonias forests in 2016, while an additional nearly 700 hunted wild boars have been documented as carrying the disease.
JOHANNESBURG (Reuters) - An outbreak of African swine fever, a severe hemorrhagic disease of pigs, has spread to a fourth province in South Africa, the agricultural ministry said on Monday, following a spate of outbreaks last month.. The ministry said the latest outbreak of the disease was reported in the Heilbron area of the central Free State Province, after the disease was detected in the countrys North West, Mpumalanga and Gauteng provinces last month.. The affected areas have been placed under quarantine and investigations were being carried out to trace the origin of the outbreaks and identify other farms that may be affected, the agriculture, forestry and fisheries ministry said in a statement.. The disease is incurable in pigs but harmless to humans. It has spread to China since last year, causing major losses to the worlds largest hog herd.. (Reporting by Tanisha Heiberg, editing by Louise Heavens) ...
BEIJING (Reuters) - China on Thursday confirmed a new outbreak of African swine fever in the Guangxi Autonomous Region, in the countrys south, as the highly contagious disease spreads through the worlds largest hog herd.. The outbreak in the city of Guigang killed 20 animals on a farm of 3,172 pigs, the Ministry of Agriculture and Rural Affairs said in a statement on its website.. China has reported 111 outbreaks of the disease in 28 of its provinces and regions since August 2018.. The disease is deadly for pigs but does not harm humans.. (Reporting by Hallie Gu and Tom Daly; editing by Christian Schmollinger). ...
The outbreaks of African Swine Fever in Bulgaria have resulted in more than 100 000 pigs being culled in the northern part of the country, Bulgarian National Television (BNT) said on the evening of August 1.. Estimates from before the outbreak of African Swine Fever put the number of registered pigs in Bulgaria at a maximum 600 000.. The Bulgarian Food Safety Agency has begun checks in small towns in northern Bulgaria to see if farmers have voluntarily got rid of their pigs, the report said.. The deadline for doing so in districts in that part of Bulgaria expired on July 31. Failure to comply means a fine of 100 to 1000 leva (about 50 to 500 euro).. Efforts by veterinary authorities in Rousse, the largest city on Bulgarias Danube border, are currently aimed at controlling the outbreak of African Swine Fever in the town of Byala, where a sick pig was found in a farmyard. In the area, 140 animals will be euthanised at six unregistered small farms.. However, employees of the Regional Food Safety ...
Bulgarian Food Safety Agency on Saturday confirmed the first outbreak of African swine fever in an industrial farm in the country.. A total of about 17,000 pigs are fattened in the farm, which is located in the village of Nikolovo near Danube River in Ruse Region, the agency said in a statement.. All pigs in the farm will be culled, and meat and products produced from pigs from the farm will be destroyed, the statement said.. The first case of African swine fever in domestic pigs in Bulgaria this year was reported on July 3, and the latest outbreak brought the total number to 17.. However, the previous 16 outbreaks were in backyard farms. As a precautionary measure, 375 domestic pigs were culled so far. ...
African swine fever is spreading slowly in the Baltic countries and Poland, according to the latest epidemiological data analysed by these Member States and EFSA.. The disease is spreading at about 2 km a month in Latvia and Estonia, and 1 km a month in Lithuania and Poland. In addition, the number of infected animals found among hunted wild boar is very low (up to 3%). The outbreaks in wild boar in the Baltic countries and Poland can therefore be defined as a small-scale epidemic.. The report covers cases reported between 2014 and 2016.. This report is the outcome of a fruitful cooperation with Member States. We look forward to continuing investigations on this disease, which has serious socio-economic consequences in affected countries, says Andrea Gervelmeyer, veterinary epidemiologist at EFSA.. The first cases of African swine fever were identified in Lithuania and in eastern Poland at the beginning of 2014. The disease was subsequently reported in Latvia and Estonia. No additional ...
African swine fever virus (ASFV) is a highly contagious disease of pigs that has a near 100% mortality rate. The disease was first reported in Kenya in 1921 and was introduced to the Caucasus region when it spread to Georgia in mid-2007. Since this introduction, ASFV has spread to Armenia, Azerbaijan, Iran, and Russia. From 2007 to 2017, Russia reported more than 1,000 ASFV outbreaks that resulted in approximately 800,000 pigs being killed. From March to October 2017, there were outbreaks of ASFV in Siberia, causing concern that the disease could spread to China. In August 2018, the FAO noted that ASFV strain detected in China was similar to the strain detected in Russia in 2017 ...
Main Article. The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.. ...
The U.S. Department of Agricultures (USDA) Animal and Plant Health Inspection Service (APHIS) added Moldova to a list of regions considered affected with African swine fever (ASF). We are taking this action because of the confirmation of ASF in Moldova. ASF is a highly contagious disease of wild and domestic swine that can spread rapidly in swine populations with extremely high rates of morbidity and mortality. A list of regions where ASF exists or is reasonably believed to exist is maintained on the APHIS Web site at https://www.aphis.usda.gov/aphis/ourfocus/animalhealth/animal-and-animal-product-import-information/ct_animal_disease_status. ...
The number of cases of African swine fever recorded in the Eastern European and Baltic states since the outbreak started in 2012 is three times the number of cases recorded in Russia since the first incident in 2007. The total number of cases in Eastern Europe since 2012 is 2,498 with 531 incidents reported this…
The spread of African swine fever in Bulgaria, which threatens the Balkan countrys pig breeding industry is worrying, an EU Commission spokeswoman said on Thursday.
In the latest episode of Contagious Thinking, join CVR PhD student Jack Hirst and postdoc Connor Bamford as they chat with Dr Charles Masembe (follow him on Twitter:@cmasembe10) about his work on some of Africas most important animal viruses.. Charles works currently on a virus called African swine fever virus (ASFV), which causes a deadly disease in domestic pigs that can cause great economic and political turmoil in affected regions. ASFV is a fascinating large DNA virus that is spread by wild pigs and the ticks that feed on them. The virus can move between the wild pigs and farmed domestic pigs. Understanding this movement is a major focus of Charles work.. Charles is a veterinarian and molecular epidemiologist by training and is an associate professor at the College of Natural Sciences at Makerere University in Uganda. He is working in a collaboration with scientists at the CVR to sequence ASFV samples from pigs across Uganda. His work is funded by a recently awarded Wellcome Trust ...
The International Atomic Energy Agency (IAEA) will provide diagnostic kits, equipment and training in nuclear-derived detection techniques to countries asking for assistance in tackling the worldwide spread of the novel coronavirus causing COVID-19. Fourteen countries in Africa, Asia, Latin America and the Caribbean have requested assistance with the diagnostic technique, known as Real-Time Reverse Transcription Polymerase Chain Reaction (RT-PCR). The Agency takes pride in its ability to respond quickly to crises, as we did in the recent past with the Ebola, Zika and African Swine Fever viruses, IAEA Director General Mariano Grossi said in a statement to the IAEA Board of Governors. Contributing to international efforts to deal with the coronavirus will remain a priority for me as long as the outbreak persists.. ...
African Swine Fever Risk Means Its Time for Action. The African swine fever (ASF) outbreak in China and in many other countries around the world is wreaking havoc on the international pork industry. Fortunately, ASF is not in the United States at this time, but the possibility of it or other foreign animal disease (FAD) means that American pig farmers must take the necessary steps to protect their farms and the domestic pork industry.. As U.S. pig farmers know, a robust export market is critical to the ongoing success of the nations pork industry. In 2018, U.S. pork and pork variety meats exports totaled 5.37 billion pounds valued at $6.392 billion, according to USDA. If an FDA such as ASF entered the United States, it would likely eliminate this entire valuation to zero for an unknown amount of time, which is why taking steps to prevent it from occurring require immediate action such as those outlined in resources in the link below.. Click here for more information.. ...
S&T released today the ASF Master Question List (MQL), a comprehensive resource that provides an up-to-date authoritative summary of publicly available information about the virus to promote coordinated research and improved emergency response preparedness.
d) an additional zone adjacent to the zones mentioned above to prevent the further spread of the disease.. Two cases of ASF in wild boar have been recently detected in Estonia in zones already under restriction, which is adjacent to the restricted zone in Latvia where cases in wild boar and backyard pig holdings were reported over the past few weeks.. The new boundaries take account of these recent findings. Since January 2014, a total of 39 outbreaks occurred in pigs and 87 notifications in wild boar occurred in these countries.. ...
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The state service of Ukraine on issues of food safety and consumer protection (state foods and consumer service) and the national police in the near future will
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The whole of the literary matter of the International Symposia on Veterinary Epidemiology and Economics proceedings is copyright International Symposia on Veterinary Epidemiology and Economics, Downloading this article signifies agreement with the terms and conditions of electronic access.. ...
The Philippines on Monday reported its first cases of African swine fever, becoming the latest country hit by the disease that has killed pigs from Slovakia to China, pushing up pork prices worldwide.
Long before Georgia 2007 appeared, another strain of ASFV arrived in Portugal in 1957. From Lisbon, the virus crept across the country and reached Spain in 1960; it leaped across that country as pigs were shuffled between recently industrialized farms. With the aid of the soft tick Ornithodoros erraticus, the virus became entrenched in Spains population of wild boars, which mingle often with domestic pigs. For the next two decades, African swine fever flared up in Western Europe, the Caribbean and Brazil. By 1985, pork producers and the Spanish government had had enough and embarked on a successful 10-year campaign of sanitation, detection and eradication. Andrés has been probing ASFVs structure and assembly pathway ever since.. One challenge of working with ASFV is the virus size. ASFV is big - a giant virus, in fact, almost twice the size of influenza virions and thicker than the typical layer of ice in which particles are suspended for cryo-electron microscopy. This complicates sample ...
AMES, Iowa - This years Iowa Swine Day will serve pork producers by offering expert speakers who will address current issues affecting the industry. Some of the topics will include the status of and response to African Swine Fever, what makes a biosecurity program successful, improving company culture, precision pork production, and feeding the high-producing sow. The event will be hosted in Ames at Iowa State University on Thursday, June 27 by the Iowa Pork Industry Center.. Iowa Swine Day is a great opportunity to learn, network, and build relationships within the swine industry, said Jason Ross, Iowa Swine Day committee chair. The topics being discussed at this years event are a result of direct input from pork producers who let us know what topics are important to them.. The morning session will feature Dr. Frank Mitloehner from the University of California-Davis, who will explore how improvements in livestock production efficiencies, genetics, nutrition, and veterinary care can help ...
Greetings! Each year I write this newsletter on the heels of the American Association of Swine Veterinarians (AASV) annual meeting. In the past, I have related the energy gained after networking with colleagues and attending outstanding CE. Im happy to report that the 2020 conference once again delivered cutting edge information presented by leaders in their field, and ample opportunities to connect with friends old and new. Topics at this years meeting included Transboundary Disease, African Swine Fever, Animal Welfare, Practitioner Well-Being, some very timely Biosecurity, and many more. Our ABVP Diplomates were heavily involved as Committee Members and Presenters. I extend my thanks to Dr. Fangman and his Exam Committee for an outstanding evaluation cycle. And heres a special shout out to Dr. Lisa Tokach, who was honored with the 2020 AASV Meritorious Service Award!. Unfortunately, this years meeting will also be remembered for the COVID-19 pandemic. Our journey to AASV began just prior ...
Introduction. Classical and African swine fever (CSF, ASF) are the two most feared diseases of swine worldwide. Both are characterised by high mortality and are transboundary diseases that can have devastating effects on livelihoods that depend on pig production (Costard et al. 2009; Moennig 2000). Although they are caused by completely unrelated viruses, the pathogenesis of the two diseases is similar, therefore the clinical and pathological manifestations are strikingly alike (Moennig 2000; Penrith, Thomson & Bastos 2004a). CSF is caused by a single-stranded RNA virus of the genus Pestivirus, family Flaviviridae, while ASF is caused by a large, double-stranded DNA virus that was only allocated to its own genus, Asfivirus, the only member of the family Asfarviridae, in 1998 (Dixon et al. 2005). Both viruses affect only members of the pig family (Suidae) (Moennig 2000; Plowright, Thomson & Neser 1994). Both are highly contagious diseases in pigs and their ancestors, the Eurasian wild boar (Sus ...
Introduction. Classical and African swine fever (CSF, ASF) are the two most feared diseases of swine worldwide. Both are characterised by high mortality and are transboundary diseases that can have devastating effects on livelihoods that depend on pig production (Costard et al. 2009; Moennig 2000). Although they are caused by completely unrelated viruses, the pathogenesis of the two diseases is similar, therefore the clinical and pathological manifestations are strikingly alike (Moennig 2000; Penrith, Thomson & Bastos 2004a). CSF is caused by a single-stranded RNA virus of the genus Pestivirus, family Flaviviridae, while ASF is caused by a large, double-stranded DNA virus that was only allocated to its own genus, Asfivirus, the only member of the family Asfarviridae, in 1998 (Dixon et al. 2005). Both viruses affect only members of the pig family (Suidae) (Moennig 2000; Plowright, Thomson & Neser 1994). Both are highly contagious diseases in pigs and their ancestors, the Eurasian wild boar (Sus ...
OTTAWA In recognition for his veterinary career, Dr. Egan Brockhoff was presented with the Merck Veterinary Award by the Canadian Veterinary Medical Association.. As a veterinarian he has contributed significantly to the advancement of food animal medicine and surgery, including herd health management. Dr. Brockhoff has brought his skills and knowledge to the Canadian pork sector and contributed greatly to its global success.. He plays an instrumental role in the ongoing development of the Canadian Pork Councils (CPC) on-farm food safety and animal care quality assurance programs. He provides both scientific and practical advice related to codes of practice, research priorities, the CPCs drug use policy and its national biosecurity standard.. Dr. Brockhoffs expertise has been critical in the identification of measures designed to prevent and, if necessary, respond to an outbreak of African swine fever. His work in this space includes contributing to the creation and implementation of the ...
Vincent ter Beek, Editor of Pig Progress. The African Swine Fever (ASF) situation in China appears to be out of control. Continental Asia will have to get used to the fact that the virus will be around for much longer. Pig Progress editor Vincent ter Beek explains why and discusses the longer-term consequences.. Kinmen Pig was found on a beach on the island of Kinmen, on New Years Eve of 2018. Many pictures were circulated on the Web. They show the animal lying on its right side, among pieces of wood, bottles and fishing nets, Id say it was about 4-5 months old. Part of its skin had turned black. The carcass was surrounded by men in white and blue biosecurity suits ...
A container with 23.94 tons of US chicken legs Chinese duty Tuesday, perhaps the beginning of a new era of trade between the two countries announced a couple of days before signing a long-awaited trade agreement. The crows feet, or phoenix claws, as they are known in Chinese recipes have been tested through the Shanghai Customs for unloading and approved, the official Securities Times reported. The event the US return of poultry meat has been scored in China five years, banned after him, he said. China has banned imports of all US poultry products in 2015, in response to cases of bird flu in America. This attitude changed in the last year, as demand for alternative animal protein increased after the spread of African swine fever in the country deadly swine herds cut and reduced pork supplies. The Asian nation is expected to increase the purchases of American agricultural products after the trade agreement signed on Wednesday in Washington, which may include a promise of $40 billion a year for ...
With African swine fever in Timor Leste, the Agriculture Minister says it is timely to conduct an exercise to make sure preparations are robust.
An outbreak of African swine fever (ASF) occurred at a farm in central Namibia in March 2018. Fourteen pigs died out of a herd of 59 animals over a period of 16 days between the first and sixteenth of March 2018. The ...
Samuel Hinneh works at the World Organisation for Animal Health (OIE) as African Swine Fever Communications Officer. Samuels mission is to optimizes awareness of the OIE and understanding of its mandate by ensuring communication around its activities regarding this disease. He is responsible for developing, implementing and monitoring communication strategies to promote the OIEs activities, in line with the organizational strategy on ASF. Samuel is also in charge of producing or coordinating the production of communication tools aligned with target groups and raising awareness of both general public and professionals. ...
The third quarter results, well below expectations, were also dragged down by volatile pork market conditions as African Swine Fever continues to devastate Asian hog herds. McCain said ASF, along with global trade issues, have made for the most erratic, irrational market conditions that this 40-year-old team has ever experienced.. Candidly, we were on the wrong side of markets that unfolded differently in the summer than what was anticipated in the spring, he said, adding that he expected more favourable market conditions to off-set the negative results in the fourth quarter.. RBC analyst Irene Nattel wrote in a Wednesday research note that the pork market and the increased SG&A expenses were the two main reasons why Maple Leaf fell well below expectations. While Maple Leafs meat results were below forecast, market volatility had also made it difficult to forecast for the company. ...
Some are calling the African Swine Fever outbreak, which has spread to China, the largest animal disease outbreak in history. The disease that is ravaging pig farms in China and other Asian countries has a similar effect on pigs as Ebola has on humans, it causes massive internal bleeding with a very high death rate.…
HANOI, Vietnam (AP) - Asian nations are scrambling to contain the spread of the highly contagious African swine fever with Vietnam culling 2.5 million pigs and China reporting more than a million dead in an unprecedentedly huge epidemic some governments fear has gone out of control. Smaller outbreaks have been reported in Hong Kong, Taiwan, […]
HANOI, Vietnam (AP) - Asian nations are scrambling to contain the spread of the highly contagious African swine fever with Vietnam culling 2.5 million pigs and China reporting more than a million...
HANOI, Vietnam (AP) - Asian nations are scrambling to contain the spread of highly contagious African swine fever, with Vietnam culling 2.6 million pigs and China reporting more than a million dead in an unprecedentedly huge epidemic some fear is out of control.
Reportable Disease List Any Suspicious or Mysterious Disease! Related Pests, Diseases, or Noxious Weeds: Disease African Swine Fever Anaplasmosis Anthrax
The National Institute for Communicable Diseases on Wednesday afternoon said the first case, which became known on Monday, involved a woman from the
Like much of America I am transfixed this morning by the House hearings with President Trumps former lawyer Michael Cohen. Leaving aside the merits of his claims, the fact that this is going on is probably seen by Xi and the Chinese trade negotiators that Trump is weakened and needs a
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Daily New York Times connects, in a wide investigative article, the nowadays swine flu wave and the one that affected Romanian farms in 2007. That particular strain affects only hogs, but - hotnews, news, articles, press review, politics, economics, sport
Galindo I, Alonso C (May 2017). "African Swine Fever Virus: A Review". Viruses. 9 (5): 103. doi:10.3390/v9050103. PMC 5454416. ... The most notable disease-causing viruses in Varidnaviria are adenoviruses, poxviruses, and the African swine fever virus (ASFV ... Many animal viruses in the realm are associated with disease, including adenoviruses, poxviruses, and the African swine fever ... which are satellite viruses of giant viruses, transpovirons, which are linear plasmid-like DNA molecules found in giant viruses ...
This virus is the cause of African swine fever. Some of the symptoms for this flu include fever, high pulse, fast breathing, ... "African swine fever (ASF) , animal disease". Encyclopedia Britannica. Retrieved 2017-12-07. "Iridoviridae-Iridoviridae-dsDNA ... the difference is that the African swine flu can not be cured. There is no vaccine developed to fight this virus. Order ... These viruses infects amoebas and can survive in low temperatures. For years this virus was believed to be frozen, but due to ...
"Sequence and evolutionary relationships of African swine fever virus thymidine kinase". Virology. 178 (1): 301-4. doi:10.1016/ ... virus specific thymidine kinases have been identified in Herpes simplex virus, Varicella zoster virus and Epstein-Barr virus. ... Kit S, Kit M, Qavi H, Trkula D, Otsuka H (1983). "Nucleotide sequence of the herpes simplex virus type 2 (HSV-2) thymidine ... McDougall JK, Masse TH, Galloway DA (1980). "Location and cloning of the herpes simplex virus type 2 thymidine kinase gene". J ...
... s were experimentally infected with the virus that causes African swine fever. It was found that the warthogs ... with African swine fever virus". Onderstepoort Journal of Veterinary Research. 47 (1): 19-22. ISSN 0030-2465. Child, Graham; ... During the late nineteenth century, P. aethiopicus became extinct in South Africa. Subsequently, study of mDNA as well as ... The desert warthog is native to the Horn of Africa. Its current range extends from southeastern Ethiopia through western ...
The thymidine kinases from pox viruses, African swine fever virus, Herpes simplex virus, Varicella zoster virus and Epstein- ... African swine fever virus (ASFV) and Fish lymphocystis disease virus (FLDV). The major capsid protein of insect iridescent ... "Sequence and evolutionary relationships of African swine fever virus thymidine kinase". Virology. 178 (1): 301-4. doi:10.1016/ ... Genes for virus specific thymidine kinases have been identified in Herpes simplex virus, Varicella zoster virus and Epstein- ...
His research also extended into African swine fever and blue tongue viruses. He prepared the UK for an epidemic of swine ... His studies included the survival of the virus in meat, concluding that the virus made use of the animal meat non-viable, a ... Brooksby, J.B. (1958). "The virus of foot-and-mouth disease". Advances in Virus Research. 5: 1-37. doi:10.1016/s0065-3527(08) ... His advice was taken on an international level, and he played a significant role in disease control in Africa and the Middle ...
The tick transmits the African swine fever virus only in Spain and Portugal. The tick feeds at night, ingesting blood to ... This species carries the pathogenic Qalyub and African swine fever viruses and the spirochetes Borrelia crocidurae and Borrelia ... "Distribution and biology of Ornithodoros erraticus in parts of Spain affected by African swine fever". The Veterinary Record. ... Kurstak, Edouard; R.G. Marusyk; F.A. Murphy & M.H.V. Van Regenmortel (1990). Applied Virology Research, Volume 2: Virus ...
... has been shown to be effective in inactivating African swine fever virus. Treatment of Oral myiasis caused by screwworm ...
"African Swine Fever Virus Causes Microtubule-Dependent Dispersal of trans-Golgi Network" (PDF). Bennett EP, Hassan H, Clausen H ...
For African swine fever virus diffusion prevention, Icheon Citizen was decided three match disclaimer. Updated to match(es) ...
Kutish GF, Rock DL, Afonso CL, Borca MV, Irusta P, Carrillo C, Brun A, Sussman M (1994). "An African swine fever virus gene ... CD2 displays structural and functional similarities with African swine fever virus (ASFV) LMW8-DR, a protein that is involved ...
Apoptosis of thymocytes in experimental African Swine Fever virus infection., Histol Histopathol. jaanuar 2004 ;19(1):77-84., ... Apoptosis of thymocytes in experimental African Swine Fever virus infection., Histol Histopathol. jaanuar 2004 ;19(1):77-84., ... Paul Chih-Hsueh Chen, Chin-Chen Pan, An-Hang Yang, Liang-Shun Wang ja Hung Chiang, Detection of Epstein-Barr virus genome ... CD4+CD8+ tümotsüütide polulatsioon oli HPAIV-infektsiooni (Highly Pathogenic Avian Influenza Virus infection) korral pea ...
The curated VBRC database contains all publicly available genomic sequences for poxviruses and African Swine Fever Viruses ( ... viral genomics and the global dominance of viruses Bioinformatic Approaches for Comparative Analysis of Viruses [1] Viral ... New Comparative Tools for Large Virus Genomes". Viruses. 10 (11): 637. doi:10.3390/v10110637. PMC 6265842. PMID 30445717. ... The goal of this level is to "allow for quick comparison of similar genes across a given virus family." VBRC provides ...
... of a radioimmunoprecipitation assay to immunoblotting and ELISA for detection of antibody to African swine fever virus". J. Vet ...
Salas, María L.; Andrés, Germán (2013). "African swine fever virus morphogenesis". Virus Research. 173: 29-41. doi:10.1016/j. ... Viroplasms have been found in the cauliflower mosaic virus, rotavirus, vaccinia virus and the rice dwarf virus. These appear ... The number and the size of viroplasms depend on the virus, the virus isolate, hosts species, and the stage of the infection. ... The viroplasm could also prevent virus degradation by proteases and nucleases. In the case of the Cauliflower mosaic virus ( ...
Neilan JG, Lu Z, Kutish GF, Sussman MD, Roberts PC, Yozawa T, Rock DL (March 1993). "An African swine fever virus gene with ... translational and transcriptional control is found in Enterobacteria and viral proteins including the African swine fever virus ...
... caused by infection with the African swine fever virus and carried by O. moubata. In wild members of the family Suidae, the ... It is an ectoparasite and vector of relapsing fever in humans, and African swine fever in pigs. Soft ticks in the family ... African swine fever is a vector-borne disease of domestic pigs, warthogs, and bushpigs, ... Valli, V.E.O.; Wood, R.D. (2016). "African swine fever". Pathology of Domestic Animals. Jubb, Kennedy & Palmer. 3. Archived ...
... sequence similarity between the dinoflagellate-infecting marine girus and the terrestrial pathogen African swine fever virus". ... Largest giant viruses with complete sequenced genomes The whole list is in the Giant Virus Toplist created by the Giant Virus ... having the largest capsid diameters of all known viruses. Viral replication in giant viruses occurs within large circular virus ... A giant virus is a very large virus, some of which are larger than typical bacteria. They are giant nucleocytoplasmic large DNA ...
In response to an outbreak of African swine fever virus on the island in 1978, U.S. agricultural authorities insisted upon ... The Program for the Eradication of Porcine Swine Fever and for the Development of Pig Raising (PEPPADEP) spread already-serious ... Ebert, Allan (1985). "Porkbarreling Pigs in Haiti: North American 'Swine Aid' an Economic Disaster for Haitian Peasants". ...
... sequence similarity between the dinoflagellate-infecting marine girus and the terrestrial pathogen African swine fever virus. ... Usutu-Virus - en. Usutu virus (USUV), Zika-Virus - en. Zika virus (ZIKV), sowie Gelbfieber-Virus - en. Yellow fever virus (YFV) ... Genus ‚Negevirus', mit Species ‚Blackford virus', ‚Bofa virus', ‚Buckhurst virus', ‚Marsac virus', sowie ‚Muthill virus'[53] ... Klassisches Schweinepest-Virus - en. Classical swine fever virus (CSFV) oder Hog cholera virus ...
Borisov's government received further criticism for its handling of African swine fever virus outbreaks which caused the ... "Why Czechia succeeded against the African swine fever and we did not". Dir.bg. 28 July 2019. Retrieved 29 July 2019. "Turkey's ... "EU Health Commissioner 'greatly disappointed' by Bulgaria's handling of African Swine Fever". The Sofia Globe. 25 July 2019. ...
... during the 1980s as part of an effort to combat an outbreak of the African swine fever virus. Haiti has been plagued for ... Hjelmgaard, Kim (12 January 2018). "U.N., African countries blast Trump's 'racist' words in angry global backlash". USA TODAY. ... Fram, Alan; Lemire, Jonathan (12 January 2018). "Trump denies he referred to Africa as a 'shithole'". Chicago Tribune. ... slaveowner who only supported manumission of African-Americans from slavery on the condition of voluntary removal to Africa) ...
... most notably the epidemic of African swine fever virus-which, at the insistence of USAID officials, led to the slaughter of the ... This class occupied a middle status between African slaves and French colonists. Africans who attained freedom also enjoyed ... Some authors wrote that the barbarism of Africa must be expelled, while maintaining African roots. Furthermore, other authors ... Not long after, he died of yellow fever, and his assistant Jean-Pierre Boyer replaced him. In this period, the eastern part of ...
In its first generation, the C3P3 enzyme would be a single-subunit protein made by the fusion of the African swine fever virus ... The C3P3 system has been used for bioproduction of recombinant proteins and reverse genetics of RNA viruses including ...
... sequence similarity between the dinoflagellate-infecting marine girus and the terrestrial pathogen African swine fever virus. ... The type species is Heterocapsa circularisquama DNA virus 01. The virus has an icosahedral capsid ~200 nanometers in diameter. ... Dinodnavirus is a genus of viruses that infect dinoflagellates. This genus belongs to the clade of nucleocytoplasmic large DNA ... During replication virions emerge from a specific cytoplasm compartment - the 'viroplasm' - which is created by the virus. The ...
... a drama festival African swine fever virus (ASFV), the causative agent of African swine fever (ASF) Altered Schaedler Flora, a ... an aviation security division in Pakistan African Standby Force, an international peace force controlled by the African Union ...
University National Taiwan University only permitted students and employees on campus ROCS Panshih African swine fever virus ... Lin, Chia-nan (1 May 2020). "Virus Outbreak: Diplomatic worker in France tests positive for virus". Taipei Times. Retrieved 1 ... Chang, Ming-hsuan; Ko, Lin (10 February 2020). "WUHAN VIRUS/Taiwan may soon discharge second recovering Wuhan virus patient". ... The virus was confirmed to have spread to Taiwan on 21 January 2020, with the first case being a 50-year-old woman who had been ...
... torque teno virus MeSH B04.280.049.035 - african swine fever virus MeSH B04.280.065.249 - granulovirus MeSH B04.280.065.500 - ... torque teno virus MeSH B04.909.204.102 - asfarviridae MeSH B04.909.204.102.035 - african swine fever virus MeSH B04.909.204.120 ... classical swine fever virus MeSH B04.909.777.411 - hepatitis delta virus MeSH B04.909.777.415 - hepatitis e virus MeSH B04.909. ... yellow fever virus MeSH B04.820.250.400 - gb virus a MeSH B04.820.250.405 - gb virus b MeSH B04.820.250.410 - GB virus C MeSH ...
... that the pork production had decreased from 50,000 tons in 2015 to 38,400 in 2017 as a result of the African swine fever virus ...
Indian swine flu (2015). *South Korean MERS (2015). *Angolan yellow fever (2016) ... "Origin of measles virus: divergence from rinderpest virus between the 11th and 12th centuries.", Virol. J., 7 (52). ... Darfur yellow fever (2012). *Swansea measles (2013). *Western African Ebola (2013-2016) ... He described the plague as "great" and of long duration, and mentioned fever, diarrhea, and pharyngitis as well as a skin ...
Dengue fever, Lassa fever, Marburg viral haemorrhagic fever, Rift Valley fever[29]) Varies - commonly viruses varies (sometimes ... Swine influenza any strain of the influenza virus endemic in pigs (excludes H1N1 swine flu, which is a human virus) pigs close ... African sleeping sickness Trypanosoma brucei rhodesiense range of wild animals and domestic livestock transmitted by the bite ... Lassa fever Lassa fever virus rodents exposure to rodents Lyme disease Borrelia burgdorferi deer, wolves, dogs, birds, rodents ...
In 2009, a swine-origin H1N1 virus strain commonly referred to as "swine flu" caused the 2009 flu pandemic, but there is no ... Swine flu. In pigs swine influenza produces fever, lethargy, sneezing, coughing, difficulty breathing and decreased appetite.[ ... which began in Russia and spread to Europe via Africa. In Rome, over 8,000 people were killed, and several Spanish cities were ... In virus classification, influenza viruses are RNA viruses that make up four of the seven genera of the family Orthomyxoviridae ...
Swine erysipelas. In 1882, Pasteur sent his assistant Louis Thuillier to southern France because of an epizootic of swine ... "South African Journal of Science. 103 (9-10): 377-380.. *^ Pasteur, Louis (1857). "Mémoire sur la fermentation alcoolique". ... Wasik, Bill; Murphy, Monica (2013). Rabid: A Cultural History of the World's Most Diabolical Virus. New York: Penguin Books. ... He reduced mortality from puerperal fever, and created the first vaccines for rabies and anthrax. His medical discoveries ...
2015-16 Zika virus epidemic Zika virus. Hundreds (as of 1 April 2016[update]) Africa 2016 2016 yellow fever outbreak in Angola ... 2015 Indian swine flu outbreak Influenza A virus subtype H1N1 [117][118][119]. ... West Africa 2013-2016 Ebola virus epidemic in West Africa Ebola virus disease. ... dengue fever. 847 (as of 10 January 2013[update]) Darfur Sudan 2012 2012 yellow fever outbreak in Darfur, Sudan yellow fever [ ...
HA Swine North America, NP Swine Eurasia and/or North America, NA Swine Eurasia, MP Swine Eurasia, NS Swine Eurasia and/or ... "H1N1 virus genome: 'This is a world first'". Independent Online (South Africa) (Press release). Cape Town. Agence France Press ... The US CDC recommended that people should wait at least a day after their fever subsides (usually 3-4 days after the onset of ... The Pandemic H1N1/09 virus is a swine origin Influenza A virus subtype H1N1 virus strain responsible for the 2009 flu pandemic ...
Swine influenza. any strain of the influenza virus endemic in pigs (excludes H1N1 swine flu, which is a human virus). pigs. ... Other haemorrhagic fevers (Marburg viral haemorrhagic fever, Lassa fever, Crimean-Congo haemorrhagic fever, Rift Valley fever[ ... African sleeping sickness. Trypanosoma brucei rhodesiense. range of wild animals and domestic livestock. transmitted by the ... West Nile fever. Flavivirus. birds, horses. mosquito bite. Zika fever. Zika virus. chimpanzees, monkeys, apes, baboons. ...
Listed diseases were fever, diphtheria, dysentery, cholera, smallpox, and influenza, with the first two being the main killers ... and the other was a virus known popularly as "curl".[47][48] Phytophthora infestans is an oomycete (a variety of parasitic, non ... 180,827 swine; (food, that is, in the shape of meat and bread, for about one half of the Irish population), and yet this very ... and has been led by such notable personalities as Archbishop Desmond Tutu of South Africa and the Choctaw Nation of Oklahoma.[ ...
Apoptosis of thymocytes in experimental African Swine Fever virus infection., Histol Histopathol. jaanuar 2004 ;19(1):77-84., ... Apoptosis of thymocytes in experimental African Swine Fever virus infection., Histol Histopathol. jaanuar 2004 ;19(1):77-84., ... Paul Chih-Hsueh Chen, Chin-Chen Pan, An-Hang Yang, Liang-Shun Wang ja Hung Chiang, Detection of Epstein-Barr virus genome ... CD4+CD8+ tümotsüütide polulatsioon oli HPAIV-infektsiooni (Highly Pathogenic Avian Influenza Virus infection) korral pea ...
The virus causes a high fever for approximately two to six days, followed by blisters inside the mouth and on the feet that may ... Africa, and South America. Symptoms of FMD in humans include malaise, fever, vomiting, red ulcerative lesions (surface-eroding ... Viral Pathways in Swine, Small Ruminants, and Wildlife; Myotropism, Chronic Syndromes, and Molecular Virus-Host Interactions". ... Like other viruses, the FMD virus continually evolves and mutates, thus one of the difficulties in vaccinating against it is ...
Famili Asfarviridae - includes African swine fever virus. *Famili Baculoviridae. *Famili Coccolithoviridae. *Famili ... Virus DNA adalah virus yang masuk pada baik Grup I atau Grup II pada sistem klasifikasi Baltimore terhadap virus. Virus ini ... "ICTVdb Index of Viruses: Virus Taxonomy, 8th Reports of the International Committee on Taxonomy of Viruses: Listing in ... Artikel bertopik virus ini adalah sebuah rintisan. Anda dapat membantu Wikipedia dengan mengembangkannya.. ...
One hypothesis is that the virus strain originated at Fort Riley, Kansas, in viruses in poultry and swine which the fort bred ... In West Africa the influenza epidemic killed at least 100,000 people in Ghana.[62] Tafari Makonnen (the future Haile Selassie, ... yellow fever, diphtheria, and cholera all occurred near the same time. These outbreaks probably lessened the significance of ... Both the H2N2 and H3N2 pandemic strains contained avian flu virus RNA segments. "While the pandemic human influenza viruses of ...
Ebola virus epidemic in West Africa). Bodily fluids. 1.5-2.5[54]. 33-60% ... Pleschka, S (2013). "Overview of Influenza Viruses". Swine Influenza. Current Topics in Microbiology and Immunology. 370. pp. 1 ... A cow with rinderpest in the "milk fever" position, 1982. The last confirmed case of rinderpest occurred in Kenya in 2001 and ... "Estimating the Reproduction Number of Ebola Virus (EBOV) During the 2014 Outbreak in West Africa". PLoS Currents. 6. doi ...
... and swine influenza viruses, allowing for mixtures of genes (reassortment) to create a new virus, which can cause an antigenic ... H5N1 has killed millions of poultry in a growing number of countries throughout Asia, Europe, and Africa. Health experts are ... Angolan yellow fever (2016). *Yemeni cholera (2016-present). *Gorakhpur Japanese encephalitis (2017) ... DNA virus. HBV (B). RNA virus. CBV. HAV (A). HCV (C). HDV (D). HEV (E). HGV (G). ...
The main mediums are bacteria, viruses, mold, and fungus (which is Latin for mushroom). It can also serve as a growth and ... This produced a typhoid fever epidemic, and food-borne illness outbreaks gained national attention. Unfortunately, it was not ... Inspection Programs To Operate Even After Finding Cutting Boards Contaminated With Old Meat And Soot-Like Residues On Swine ... 2017-18 South African listeriosis outbreak. *2018 Australian rockmelon listeriosis outbreak. *2018 Australian strawberry ...
CDC Archived 2012-11-29 at WebCite article Genome Analysis Linking Recent European and African Influenza (H5N1) Viruses EID ... Flu virus-induced increases in the level of cytokines is also associated with flu symptoms, including fever, chills, vomiting ... November 5, 2009 "The Cat Who Got Swine Flu." ''New York Times.''". Well.blogs.nytimes.com. Archived from the original on ... Influenza A virus subtype H5N1, also known as A(H5N1) or simply H5N1, is a subtype of the influenza A virus which can cause ...
Indian swine flu (2015). *South Korean MERS (2015). *Angolan yellow fever (2016) ... eastern Africa, and the Mediterranean coast. While cholera had spread across India many times previously, this outbreak went ... Kerala Nipah virus (2018). *Équateur province Ebola (2018). *Kivu Ebola (2018-2020) ...
DNA virus. HBV (B). RNA virus. CBV. HAV (A). HCV (C). HDV (D). HEV (E). HGV (G). ... "WHO , Regional Office for Africa. Retrieved 20 August 2019.. *^ Khudyakov, Yury E.; Purdy, Michael A. (17 December 2010). " ... deer and swine have frequently been implicated.[58] Domestic animals have been reported as a reservoir for the hepatitis E ... DNA virus. Human polyomavirus 2 Progressive multifocal leukoencephalopathy. RNA virus. MeV Subacute sclerosing panencephalitis ...
The DIVA strategy has been applied in various countries and successfully eradicated pseudorabies virus. Swine populations were ... South African Institute for Medical Research (1929). Annual report [Jaarverslag]. South African Institute for Medical Research ... classical swine fever,[109] avian influenza,[110] Actinobacillus pleuropneumonia[111] and Salmonella infections in pigs.[112] ... "Glycoprotein E1 of hog cholera virus expressed in insect cells protects swine from hog cholera". Journal of Virology. 67 (9): ...
Soon scientist cultivated other viruses in eggs. Eggs were used for virus propagation in the development of a yellow fever ... South African Institute for Medical Research (1929). Annual report [Jaarverslag]. South African Institute for Medical Research ... such as classical swine fever,[123] avian influenza,[124] Actinobacillus pleuropneumonia[125] and Salmonella infections in pigs ... "Glycoprotein E1 of hog cholera virus expressed in insect cells protects swine from hog cholera". Journal of Virology. 67 (9): ...
Zika virus Igciwane iZika[hlela , Hlela umthombo]. Indaba ephelele: 2015-16 Zika virus epidemic, Zika virus, and Zika fever ... A. M., Dumar (2009). Swine Flu: What You Need to Know. Wildside Press LLC. p. 7. ISBN 978-1434458322. ... Sub-Saharan Africa iyona ndawo enabantu abaningi abathelelekayo. Ngo-2018 bebelinganiselwa emaphesentini angu-61 abathelelekile ... Izibonelo kubalwa kuzo i-Ebola virus disease, Lassa fever, Rift Valley fever, Marburg virus disease ne Bolivian hemorrhagic ...
Indian swine flu (2015). *South Korean MERS (2015). *Angolan yellow fever (2016) ... Darfur yellow fever (2012). *Swansea measles (2013). *Western African Ebola (2013-2016) ... Kerala Nipah virus (2018). *Équateur province Ebola (2018). *Kivu Ebola (2018-2020) ...
West Nile virus, Yersinia pestis and Dengue fever virus.[17] ... West Nile virus, obesity, avian, swine, and pandemic flu, E. ... During the 2014 Ebola outbreak in West Africa, the CDC helped coordinate the return of two infected American aid workers for ... The CDC runs a program that protects the public from rare and dangerous substances such as anthrax and the Ebola virus. The ... The CDC has launched campaigns targeting the transmission of influenza, including the H1N1 swine flu, and launched websites to ...
HIV/AIDS is the leading epidemic that affects the social welfare of Africa. Human Immunodeficiency virus (HIV) can cause AIDS ... The Swine Flu (also known as (H1N1) epidemic is a recent disease emerging in the early 21st century. In April 2009, during the ... The rapid urbanization of Australia led to epidemics of typhoid fever and the Bubonic plague. Because of this, public health ... They called it "Hepatitis Delta Virus" (HDV). This new virus was found to be defective. HDV needed HBV to act as a helper ...
African swine fever for pigs, and psittacosis to kill chicken. These agents were prepared to be sprayed down from tanks ... Q-fever) Venezuelan equine encephalitis virus (VEE) Botulinum toxin (botulism) Staphylococcal enterotoxin B Smallpox Marburg ... Ustinov who was accidentally killed by the virus. The samples of Marburg taken from Ustinov's organs were more powerful than ... It was produced by injecting small amounts of the virus into chicken eggs. An especially virulent strain (codenamed India-1967 ...
... swine).[52] The rapid spread of this new virus was likely due to a general lack of pre-existing antibody-mediated immunity in ... from Asia to Europe and Africa, birds infected with the H5N1 virus could reach the Americas within the next six to 12 months.[ ... the influenza viruses). In humans, common symptoms of influenza infection are fever, sore throat, muscle pains, severe headache ... The 1977 virus was similar to other A/H1N1 viruses that had circulated prior to 1957. The virus was included in the 1978-79 ...
If due to a virus, the condition usually resolves within one week.[18] Some viral infections also involve fever, fatigue, ... Zimmerman, Jeffrey; Karriker, Locke; Ramirez, Alejandro; Kent Schwartz; Gregory Stevenson (15 May 2012). Diseases of Swine ( ... In Africa and Asia these vaccines reduced severe disease among infants[44] and countries that have put in place national ... DNA virus. HBV (B). RNA virus. CBV. HAV (A). HCV (C). HDV (D). HEV (E). HGV (G). ...
Virus Sections. Virus Name/Prototype. Original Source. Method of Isolation. Virus Properties. Antigenic Relationship. Biologic ... Virus Source (all VERTEBRATE isolates). Blood (LV), heart (LV), lung (LV), liver (LV), spleen (LV), kidney (LV), nasopharyngeal ... Lab Methods of Virus Recovery (ALL ISOLATIONS). Normal pigs, primary and continuous porcine cell cultures ... Click on the PDF icon to the left to view a copy of this virus entry in PDF format. You can get a copy of the PDF viewer by ...
Virus Sections. Virus Name/Prototype. Original Source. Method of Isolation. Virus Properties. Antigenic Relationship. Biologic ... Click on the PDF icon to the left to view a copy of this virus entry in PDF format. You can get a copy of the PDF viewer by ... Virus Name: African swine fever Abbreviation: ASFV Status. Arbovirus Select Agent. No SALS Level. ...
China reported another outbreak of deadly African swine fever late on Monday, its third new case in two days, as the highly ... HONG KONG/BEIJING (Reuters) - China reported another outbreak of deadly African swine fever late on Monday, its third new case ... The latest case, the eighth since the virus was first reported in the country a month ago, was found in the city of Wuxi, the ... The virus is transmitted by ticks and direct contact between animals, and can also travel via contaminated food, animal feed ...
China detected African swine fever in pigs being transported to Guangxi region from outside provinces, the agriculture ministry ... The deadly African swine fever disease is much more severe than officially reported in China, leading to the death or killing ... BEIJING (Reuters) - China detected African swine fever in pigs being transported to Guangxi region from outside provinces, the ...
ARS scientists have identified a new way to detect the presence of live African Swine Fever Virus that minimizes the need for ... samples from live animals and provides easier access to veterinary labs that need to diagnose the virus ... Commercially Available Cell Line Rapidly Detects African Swine Fever Virus. By Autumn Canaday. July 28, 2020 ... "This is a critical breakthrough and a tremendous step for African Swine Fever Virus diagnostics." ...
Government and academic investigators have developed a vaccine against African swine fever that appears to be far more ... which has been devastating the swine industry in Eastern Europe and Southeast Asia. African swine fever virus (ASFV) is highly ... New experimental vaccine for African swine fever virus shows promise. American Society for Microbiology ... The 2007 outbreak was also the genesis of the African swine fever that has been spreading through Eastern Europe and east Asia ...
The ends of African swine fever virus genome are formed by a 37 nucleotide-long hairpin loop composed, almost entirely, of ... Hairpin loop structure of African swine fever virus DNA.. González A, Talavera A, Almendral JM, Viñuela E. ... The hairpin loops of African swine fever and vaccinia virus DNAs had no homology, but both DNAs had a 16 nucleotide-long ... An analysis of African swine fever virus replicating DNA showed head-to-head and tail-to-tail linked molecules that may be ...
"African Swine Fever (ASF)". PigSite. Archived from the original on 2018-06-14. Retrieved 2010-01-28. "African Swine Fever". ... In July, 3 farms discovered African swine fever in Estonia. [...] African swine fever spreads to farmed pigs, 500 animals to be ... Viruses portal Veterinary virology Dixon; et al. (2008). "African Swine Fever Virus". Animal Viruses: Molecular Biology. ... African swine fever virus (ASFV) is a large, double-stranded DNA virus in the Asfarviridae family. It is the causative agent of ...
AFRICAN SWINE FEVER VIRUS (ISOLATE LISBON 60 / LIS60). ›African swine fever virus Lisbon 60/lis60. ›African swine fever virus ... Taxonomy - African swine fever virus (isolate Pig/Portugal/Lis 60/1960) (ASFV) Basket 0 ... African swine fever virus (isolate Pig/Portugal/Lis 60/1960). Taxonomy navigation. › African swine fever virus ... Viruses. › Varidnaviria. › Bamfordvirae. › Nucleocytoviricota. › Pokkesviricetes. › Asfuvirales. › Asfarviridae. › Asfivirus. ...
The causative agent of ASF is a large double-stranded linear DNA virus with a complex structure. There are twenty-four ASFV ... Continuous virus characterization enhances the understanding of ASF epidemiology in terms of viral genome variations, extent, ... Intragenotypic resolution of the CVR region revealed major deletions in the virus genome, in some isolates of this study. The ... severity, and the potential source of the viruses responsible for outbreaks. We collected samples from pigs that had died of a ...
Virus-Cell Interactions. Identification of a Functional Small Noncoding RNA of African Swine Fever Virus African swine fever ( ... The African Swine Fever Virus Transcriptome African swine fever virus (ASFV) causes incurable and often lethal hemorrhagic ... A Proteomic Atlas of the African Swine Fever Virus Particle African swine fever virus causes a highly contagious and lethal ... African swine fever (ASF) is a highly contagious hemorrhagic viral disease in pigs that is caused by African swine fever virus ...
... is a highly lethal haemorrhagic disease in domestic and wild swine that has acquired great importance in sub-Saharan Africa ... African swine fever virus evasion of host defences.. African swine fever virus causes a haemorrhagic fever in domestic pigs and ... African swine fever: an unprecedented disaster and challenge to China.. African swine fever (ASF), caused by African swine ... Summary of "Genetic characterization of African swine fever virus in Cameroon, 2010-2018.". African swine fever (ASF) is a ...
With an estimated 34 million pigs in sub-Saharan Africa, the development of an African swine fever vaccine could benefit up to ... African swine fever (ASF) is a highly infectious hemorrhagic viral disease that wipes out entire herds of infected pigs. ASF is ... There is currently no treatment or vaccine against African swine fever. A major roadblock to the development of a new vaccine ... By adopting this cutting-edge approach to the development of African swine fever vaccines, the overall expected result is the ...
This virus is a member of the iridovirus group that causes African swine fever. Unlike other DNA- containing vertebrate viruses ... African swine fever virus, illustration. This virus is a member of the iridovirus group that causes African swine fever. Unlike ... Keywords: 3 dimensional, 3d, african swine fever virus, artwork, biological, biology, cgi, digitally generated, dna virus, ... swine, three dimensional, viral, virion, virology, virus ... African swine fever virus, illustration. F016/8841 Royalty Free ...
African swine fever virusAgricultureAlan MilburnAquAdvantage salmonFood and Drug AdministrationGenetically modified organism ... "African swine fever virus". MARTHA ROSENBERG - Brave New Food: GEs and Clones are Heading to the Dinner Table Consumers, safety ...
Nuclear export of African swine fever virus p37 protein occurs through two distinct pathways and is mediated by three ... Nuclear Export of African Swine Fever Virus p37 Protein Occurs through Two Distinct Pathways and Is Mediated by Three ... Nuclear Export of African Swine Fever Virus p37 Protein Occurs through Two Distinct Pathways and Is Mediated by Three ... Nuclear Export of African Swine Fever Virus p37 Protein Occurs through Two Distinct Pathways and Is Mediated by Three ...
... is a double-stranded DNA virus causing a hemorrhagic fever disease with high mortality rates and severe economic losses in pigs ... Keywords: African swine fever virus; aggresome; HDAC6; BAG3; viral factories African swine fever virus; aggresome; HDAC6; BAG3 ... African swine fever virus (ASFV) is a double-stranded DNA virus causing a hemorrhagic fever disease with high mortality rates ... "Analysis of HDAC6 and BAG3-Aggresome Pathways in African Swine Fever Viral Factory Formation." Viruses 7, no. 4: 1823-1831. ...
African swine fever (ASF) is arguably the most dangerous swine disease worldwide. ASF virus (ASFV) is highly virulent for ... African swine fever in the North Caucasus region and the Russian Federation in years 2007-2012. Virus Res. 2013;173:198-203. ... African Swine Fever Virus, Siberia, Russia, 2017. Emerging Infectious Diseases. 2018;24(4):796-798. doi:10.3201/eid2404.171238. ... Kolbasov D, Titov I, Tsybanov S, Gogin A, Malogolovkin A. African Swine Fever Virus, Siberia, Russia, 2017. Emerg Infect Dis. ...
African swine fever (ASF) is a highly contagious and deadly hemorrhagic disease of domestic pigs caused by African swine fever ... Genetic characterization of African swine fever viruses from outbreaks in southern Africa (1973-1999). Vet Microbiol. 2007;121: ... Rowlands RJ, Michaud V, Heath L, Hutchings G, Oura C, Vosloo W, African swine fever virus isolate, Georgia, 2007. Emerg Infect ... Gallardo C, Anchuelo R, Pelayo V, Poudevigne F, Leon T, Nzoussi J, African swine fever virus p72 genotype IX in domestic pigs, ...
Browse by Exposure: African Swine Fever Virus (1 article). % of records by year: 1965 2017 ...
... today announced that an African Swine Fever Virus vaccine candidate has been adapted to grow in a cell line, which means that ... A cell culture-adapted vaccine virus against the current pandemic African swine fever virus strain, Journal of Virology (2021 ... African swine fever virus vaccine candidate now produced in a cell line. by Autumn Canaday, Agricultural Research Service ... Citation: African swine fever virus vaccine candidate now produced in a cell line (2021, May 7) retrieved 19 June 2021 from ...
ASF is caused by a large DNA virus, African swine fever virus (ASFV), and there is currently no vaccine against it. A major ... Developing Genetic Tools to Manipulate African Swine Fever Virus and Generate Attenuated Strains. ... Developing Genetic Tools to Manipulate African Swine Fever Virus and Generate Attenuated Strains. ... Developing Genetic Tools to Manipulate African Swine Fever Virus and Generate Attenuated Strains ...
ASF is caused by a large DNA virus, African swine fever virus (ASFV), and there is currently no vaccine against it. A major ... Developing Genetic Tools to Manipulate African Swine Fever Virus and Generate Attenuated Strains. ... African swine fever (ASF) is a devastating hemorrhagic disease of pigs with mortality rates up to 100% in infected pig herds. ... It is prevalent in many sub-Saharan African countries, causing major economic losses and threatening food security. Due to this ...
What is African swine fever virus?. ASFV is a pig disease thats both highly contagious and very deadly. It has no cure or ... By imitating the conditions of a cargo ship using an environmental chamber, Niederwerder found that African swine fever virus ( ... Study finds African swine fever virus can survive international feed shipments. April 12, 2018 ... and determined what amount of swine fever virus in the feed was required for the virus to spread. The study also examined ...
Detection of novel sequences related to african Swine Fever virus in human serum and sewage. Language Catalan ... Detection of novel sequences related to african Swine Fever virus in human serum and sewage ...
ANIMAL VIRUSES. African Swine Fever Virus Is Wrapped by the Endoplasmic Reticulum. Isabelle Rouiller, Sharon M. Brookes, Alex D ... African Swine Fever Virus Is Wrapped by the Endoplasmic Reticulum. Isabelle Rouiller, Sharon M. Brookes, Alex D. Hyatt, Miriam ... African Swine Fever Virus Is Wrapped by the Endoplasmic Reticulum. Isabelle Rouiller, Sharon M. Brookes, Alex D. Hyatt, Miriam ... African Swine Fever Virus Is Wrapped by the Endoplasmic Reticulum Message Subject (Your Name) has forwarded a page to you from ...
Africa Swine Fever Virus Genome Sequencing to underpin Control. Africa Swine Fever Virus Genome Sequencing to underpin Control ... western and southern Africa. Currently there is no reliable data on total numbers of farmers affected in Africa; this project ... Whats new about this project for Africa is that it combines social and economic research with biological surveillance of viral ... Biosciences eastern and central Africa, Commonwealth Scientific and Industrial Research Organisation, Australia ...
Read K-State Researchers Work to Stay Ahead of African Swine Fever Virus in addition to hundreds of recent farming and ... "African Swine Fever virus is a terrible disease that affects only swine," said Cassie Jones, a swine nutritionist with K-State ... K-State researchers currently are studying the African Swine Fever virus in collaboration with Megan Niederwerder, Steve Dritz ... Now, that work may help to fend off the threat from the African Swine Fever virus. ...
A sequence comparison of the VP72 gene of African Swine Fever Virus LUCAS J. PITCHER; LUCAS J. PITCHER ... LUCAS J. PITCHER, LINDA K. DIXON, PHILIP C. TURNER; A sequence comparison of the VP72 gene of African Swine Fever Virus. ... Transcriptome view of a killer: African swine fever virus Biochem Soc Trans (July,2020) ... Exceptionally diverse morphotypes and genomes of crenarchaeal hyperthermophilic viruses Biochem Soc Trans (April,2004) ...
African swine fever virus (ASFV) is the causative agent of African swine fever (ASF) that is the significant disease of ... Infection of pigs with African Swine Fever virus resulted in changes in the composition of white blood cells, according to new ... Scientists have identified a new way to detect the presence of live African swine fever virus (ASFV) that minimizes the need ... Pathology of Porcine Peripheral White Blood Cells during Infection with African Swine Fever Virus. Disease and welfare ...
  • WASHINGTON, July 28, 2020 -Scientists from the U.S. Department of Agriculture's (USDA) Agricultural Research Service (ARS) have identified a new way to detect the presence of live African Swine Fever Virus (ASFV) that minimizes the need for samples from live animals and provides easier access to veterinary labs that need to diagnose the virus. (usda.gov)
  • Until now, effectively detecting live ASFV required collecting blood cells from a live donor swine for every diagnostic test, because the cells could only be used once. (usda.gov)
  • The new cell line is also commercially available to veterinary diagnostic labs that traditionally did not have access to swine blood cells needed to test for live ASFV. (usda.gov)
  • Recent outbreaks of ASFV outside the African continent started after a single introduction of ASFV in the Republic of Georgia in 2007. (usda.gov)
  • African swine fever virus (ASFV) is highly contagious and often lethal to domestic and wild pigs. (eurekalert.org)
  • This is also a new strain of the virus, now known as ASFV-G (the G stands for Georgia). (eurekalert.org)
  • There is limited cross-protection between strains of African swine fever, likely because the antigens and degree of virulence differ among them, and none of the historical experimental vaccines have been shown to be effective against ASFV-G, said Dr. Gladue. (eurekalert.org)
  • African swine fever virus (ASFV) is a large, double-stranded DNA virus in the Asfarviridae family. (wikipedia.org)
  • ASFV is endemic to sub-Saharan Africa and exists in the wild through a cycle of infection between ticks and wild pigs, bushpigs, and warthogs. (wikipedia.org)
  • ASFV is a large, icosahedral, double-stranded DNA virus with a linear genome of 189 kilobases containing more than 180 genes. (wikipedia.org)
  • All ASFV p72 genotypes have been circulating in eastern and southern Africa. (wikipedia.org)
  • African swine fever virus (ASFV) is the lone member of genus Asfivirus and class Asfarviridae [ 2 ]. (hindawi.com)
  • In Uganda, the previously characterized ASFV viruses have been classified into genotype IX [ 14 , 15 ] and genotype X [ 16 ]. (hindawi.com)
  • African swine fever (ASF) is a highly contagious hemorrhagic viral disease in pigs that is caused by African swine fever virus (ASFV). (asm.org)
  • African swine fever virus (ASFV) is a member of the nucleocytoplasmic large DNA virus superfamily that predominantly replicates in the cytoplasm of infected cells. (asm.org)
  • African swine fever virus (ASFV) causes incurable and often lethal hemorrhagic fever in domestic pigs. (asm.org)
  • All the identified virus isolates were classified as ASFV genotype I based on the partial B646L gene (C-terminal end of VP72 gene) and the full E183L gene encoding p54 protein analysis. (bioportfolio.com)
  • African swine fever virus (ASFV) is a double-stranded DNA virus causing a hemorrhagic fever disease with high mortality rates and severe economic losses in pigs worldwide. (mdpi.com)
  • ASF virus (ASFV) is highly virulent for domestic swine and remains a global threat because no effective vaccine is available to eradicate the disease. (cdc.gov)
  • African swine fever (ASF) is a highly contagious and deadly hemorrhagic disease of domestic pigs caused by African swine fever virus (ASFV), a double-strand DNA virus of the family Asfarviridae and genus Asfivirus ( 1 ). (cdc.gov)
  • Historically, all ASFV p72 genotypes have been circulating in eastern and southern Africa, and genotype I has been circulating in Europe, South America, the Caribbean, and western Africa ( 2 , 3 ). (cdc.gov)
  • Spread of ASFV beyond traditional geographic boundaries occurred with incursion of p72 genotype II into the Republic of Georgia and its subsequent spread into Armenia, Azerbaijan, and Russia ( 4 , 5 ) and incursion of genotype IX into western Africa ( 6 ). (cdc.gov)
  • ASF is caused by a large DNA virus, African swine fever virus (ASFV), and there is currently no vaccine against it. (jcvi.org)
  • By imitating the conditions of a cargo ship using an environmental chamber, Niederwerder found that African swine fever virus (ASFV) could survive in feed over, for example, a 30-day trans-Atlantic journey. (neogen.com)
  • There are many countries, including the U.S., that are currently free of ASFV and it is critical to understand how we can prevent this virus from being introduced. (neogen.com)
  • African swine fever virus (ASFV) is the causative agent of African swine fever (ASF) that is the significant disease of domestic pigs, according to a paper published recently in BMC Veterinary Research . (thepigsite.com)
  • The African swine fever virus (ASFV) j13L gene encodes a 177 amino acid protein (19.0 kDa) with a putative transmembrane domain between residues 32 and 52. (nih.gov)
  • Rabbit antisera raised against a synthetic peptide from the C terminus of the j13L ORF identified proteins of 25-27 kDa in cells infected with a recombinant vaccinia virus expressing the j13L ORF, in ASFV-infected cells and in purified extracellular ASF virions. (nih.gov)
  • Although ASFV-infected animals made antibodies to the j13L protein, no protection was observed when pigs were vaccinated with a recombinant vaccinia virus expressing the j13L ORF. (nih.gov)
  • A stochastic model designed to simulate transmission dynamics of African swine fever virus (ASFV) in a free-ranging pig population under various intervention scenarios is presented. (eurekamag.com)
  • DNA fragments amplified from the genome of the isolates from domestic pigs in Georgia in 2007 were sequenced and compared with other ASF virus (ASFV) isolates to establish the genotype of the virus. (up.ac.za)
  • MBF Therapeutics, the leader in the development of DNA-based immunotherapeutic checkpoint inhibitor vaccines for the animal health market, has assembled a team of African Swine Fever Virus (ASFV) researchers to develop an effective, broad-spectrum ASFV vaccine, leveraging MBF Therapeutics' proprietary immunotherapy platform and delivery system. (mriglobal.org)
  • Thus far, attempts to develop an effective ASFV vaccine have taken conventional approaches albeit with incremental improvements, such as gene-deleted modified live virus, protein subunits, and a small assortment of gene-based antigens. (mriglobal.org)
  • The ASFV (African swine fever virus) is a type of uncoated particles with a diameter of 172-220 nm. (creative-biolabs.com)
  • The ASFV was first discovered in Kenya in 1921 and has so far become popular in dozens of countries in Africa, Europe and America. (creative-biolabs.com)
  • African swine fever virus (ASFV) is characterized by high stability and effective spread. (essays.se)
  • The aim of the study was to assess whether blood samples collected onto FTA® cards could be used in combination with real-time PCR for the detection of African swine fever virus (ASFV) DNA in samples from resource-poor settings under the assumption that asymptomatically (sub-clinically) infected pigs may be present. (dtu.dk)
  • African swine fever virus (ASFV) is a large DNA virus that assembles in viral factories located close to the microtubule organising centre. (surrey.ac.uk)
  • Consistent with a role for conventional kinesin during ASFV egress, over-expression of the cargo-binding domain of the kinesin light chain, which acts as a dominant negative protein, severely inhibits movement of viruses to the plasma membrane. (surrey.ac.uk)
  • It is caused by the African swine fever virus (ASFV), a deoxyribonucleic acid (DNA) arbovirus. (up.ac.za)
  • A total of 562 ticks were screened for virus genome presence using a duplex Polymerase Chain Reaction (PCR) that targets the C-terminal end of the p72 gene of the ASFV and confirms DNA integrity through amplification of the 16S rRNA tick host gene. (up.ac.za)
  • WASHINGTON -The African Swine Fever virus (ASFV) is a highly contagious disease that spreads rapidly in pig populations. (kticradio.com)
  • To help keep the U.S. ASFV-free and protect the country's pigs, the Foundation for Food and Agriculture Research (FFAR) and the National Pork Board (NPB) awarded $535,780 to research teams at Kansas State University and Iowa State University to study how ASFV survives and how to test pigs for the virus. (kticradio.com)
  • ASFV has existed in Africa for decades. (kticradio.com)
  • ASFV entered China in August 2018 and is now quickly infecting swine herds across the globe. (kticradio.com)
  • Even though ASFV does not affect human health, it threatens the $20 billion-dollar U.S. swine industry and the 550,000 American jobs created by the industry. (kticradio.com)
  • African swine fever virus (ASFV) causes a devastating disease of pigs. (pirbright.ac.uk)
  • African swine fever virus (ASFV) causes a severe disease in domestic pigs and wild boar that can result in death in almost all pigs that are infected. (pirbright.ac.uk)
  • This work provides a novel, highly sensitive, hot start PCR method for rapid and specific detection of African swine fever virus (ASFV) that can be used as a routine diagnostic test for ASFV in surveillance, control, and eradication programs. (semanticscholar.org)
  • Understanding ASF virus (ASFV) transmission dynamics within a herd is necessary in order to prepare for and respond to an outbreak in the United States. (researchsquare.com)
  • African swine fever virus (ASFV) is the causal agent of African swine fever, a hemorrhagic and often lethal porcine disease causing enormous economical losses in affected countries. (biomedcentral.com)
  • Live attenuated viruses have been demonstrated to induce very efficient protective immune responses, albeit most of the time protection was circumscribed to homologous ASFV challenges. (biomedcentral.com)
  • These findings will be of utility for a better understanding of ASFV pathogenesis and for the rational designing of safe and efficient vaccines against this virus. (biomedcentral.com)
  • African swine fever (ASF) is a highly pathogenic disease caused by African Swine Fever Virus (ASFV), a rather complex virus against which there is no vaccine available. (biomedcentral.com)
  • Only 10 years after its eradication from continental Europe, ASFV re-entered Europe arriving from Africa to the Caucasian Republic of Georgia in 2007. (biomedcentral.com)
  • Here we tested the antiviral activity of two RAFIs, 5-(Perylen-3-ylethynyl)-arabino-uridine (aUY11) and 5-(Perylen-3-ylethynyl)uracil-1-acetic acid (cm1UY11) against African swine fever virus (ASFV), for which no effective vaccine is available. (microbiologyresearch.org)
  • Scientists at The Pirbright Institute have identified African swine fever virus (ASFV) proteins that can induce cellular and humoral immune responses in pigs. (star-idaz.net)
  • The Pirbright Institute has announced that it will partner with the Belgian biotechnology company ViroVet to develop the first antiviral drugs that act against African swine fever virus (ASFV). (star-idaz.net)
  • An article published in Frontiers in Veterinary Science describes the experimental vaccination of wild boar against African swine fever virus (ASFV). (star-idaz.net)
  • Oral immunization of wild boar with a non-haemadsorbing, attenuated ASFV of genotype II conferred 92% protection against challenge with a virulent ASF virus isolate (Arm07). (star-idaz.net)
  • Researchers have found that African swine fever virus (ASFV) could survive in a simulated Trans-Atlantic feed shipment. (star-idaz.net)
  • Researchers have found that deleting a gene of African swine fever virus (ASFV) reduces its ability to cause infection and protects against a strain of the virus that causes severe disease. (star-idaz.net)
  • A DNA-copying protein from African swine fever virus (ASFV) has a unique structure that may offer a target for drugs, according to a study published in PLoS Biology by Yiqing Chen and colleagues at Fudan University in Shanghai, China. (star-idaz.net)
  • ASF virus (ASFV) infects wildlife hosts and ticks of has since spread to neighboring countries. (cdc.gov)
  • In Africa, where ASF pigs in Georgia in 2007 were sequenced and compared is widespread, the virus causes long-term, persistent infec- with other ASF virus (ASFV) isolates to establish the geno- type of the virus. (cdc.gov)
  • The level of diversity between isolates virus is closely related to ASFV isolates typically found in from these regions is attributed to the long-term evolution Mozambique, Madagascar, and Zambia ( 4 , 11 , 12 ). (cdc.gov)
  • The etiological agent that causes the highly lethal disease is the African swine fever virus (ASFV) (Sanchez-Vizcaino et al . (virosin.org)
  • 2013). In addition, ASFV also infects African wild suids, including warthogs ( Phacochoerus africanus ) and bushpigs ( Potamochoerus larvatus ), which act as asymptomatic carriers. (virosin.org)
  • In East Africa, ASFV is maintained in an ancient sylvatic cycle involving warthogs and soft ticks ( Ornithodoros genus) that inhabit their burrows (Jori et al . (virosin.org)
  • Studies on virus-host interactions are decisive to enhance our understanding on how African swine fever virus (ASFV) subverts cellular mechanisms, and also to better characterize host nucleus changes enabling this infection. (utl.pt)
  • Infection of cells with African swine fever virus (ASFV) can lead to the formation of zipper-like stacks of structural proteins attached to collapsed endoplasmic reticulum (ER) cisternae. (elsevier.com)
  • Scientists have mapped genes across the African swine fever virus (ASFV) genome, which they believe could help in the search for a vaccine and antiviral drugs to prevent the devastating disease. (pig-world.co.uk)
  • For comparison, the influenza virus expresses eight genes, whereas ASFV expresses between 150 and 190, which has so far made it difficult for scientists to identify and determine the significance of each gene. (pig-world.co.uk)
  • Table 1 Composition of white blood cells during acute ASFV infection in swine. (biomedcentral.com)
  • African swine fever virus (ASFV) is a highly resistant viraemic virus with devastating socio-economic impact. (actipro.biz)
  • African swine fever (ASF) is an infectious disease affecting domestic and wild pigs caused by African swine fever virus (ASFV) belonging to the Asfarviridae family. (biomedcentral.com)
  • Upon viral entry, ASFV inhibits autophagy persistently throughout the infectious cycle to facilitate replication and to avoid virus clearance. (uam.es)
  • The ASFV--‐mediated autophagy inhibition is a tightly regulated process, since altering key autophagy factors impairs infectivity, the formation of the ASFV viral factories and the replication of the virus overall. (uam.es)
  • Finally, our studies established a link between autophagy, ASFV infection and innate immunity by the expression of the interferon--‐induced transmembrane (IFITM) protein family, which possesses antiviral properties against several viruses. (uam.es)
  • The expression of surface markers on African swine fever virus (ASFV) infected cells was evaluated to assess their involvement in infection. (angiogenesis-blog.com)
  • Researchers at Kansas State University are creating African Swine Fever Virus (ASFV) subunit vaccine candidates using next-generation vectors. (whiteboard2boardroom.com)
  • More importantly, this prototype vaccine conferred 56% protection in an ASFV swine challenge study. (whiteboard2boardroom.com)
  • His team's new approach at K-State will start by incorporating up to 100 conserved ASFV antigens that contain putative CTL epitopes within the next generation replicon vectors to determine if higher than 56% efficacy can be achieved in a future swine challenge study. (whiteboard2boardroom.com)
  • The ASFV-G-ΔI177L virus strain is an African swine fever virus (AFSV) deletion mutant derived from AFSV Georgia strain. (cdc.gov)
  • Moreover, drugs that bind to the minor groove may be exploited when pursuing a subset of viruses that replicate in the cytoplasm, such as the African swine fever (ASF) virus (ASFV). (paperity.org)
  • Nucleotide sequencing of the SalI j region of the virulent Malawi (LIL20/1) strain of African swine fever virus (ASFV) identified an open reading frame (ORF), designated j9L, with extensive similarity to the family of protein kinases. (ox.ac.uk)
  • In this study, we assessed the infection generated in 7-week-old CSFV PI wild boars after infection with the African swine fever virus (ASFV). (beds.ac.uk)
  • Background African swine fever virus (ASFV) is the only known DNA-arbovirus and a most devastating suid pathogen that, originating from a sylvatic cycle in Africa, has spread to eastern Europe and recently reached western Europe and Asia, leading to a socio-economic crisis of global proportion. (cdc.gov)
  • However, since neither closely related viruses nor integrated viral elements have yet been identified, ASFV evolution remains a mystery. (cdc.gov)
  • Results Here, we show that soft ticks of the Ornithodoros moubata group, the natural arthropod vector of ASFV, harbour African swine fever virus-like integrated (ASFLI)-elements corresponding to up to 10% (over 20 kb) of the ASFV genome. (cdc.gov)
  • Conclusion We suggest that this mechanism of protection, shaped through many years of co-evolution, is part of an evolutionary virus-vector "arms race", a finding that has not only high impact on our understanding of the co-evolution of viruses with their hosts but also provides a glimpse into the evolution of ASFV. (cdc.gov)
  • The aims of the study were to investigate the practical feasibility of non-invasive ropein-a-bait (pSWAB) oral fluid sampling method for collection of oral fluid samples from wild boar in field conditions, and its suitability for detection of African swine fever virus (ASFV) infection in wild boar population in infected area. (emu.ee)
  • In the present study, no ASFV was detected in wild boar, although the virus was circulating in the wild boar population in the immediate vicinity during the period when the study was conducted. (emu.ee)
  • BEIJING (Reuters) - China detected African swine fever in pigs being transported to Guangxi region from outside provinces, the agriculture ministry said on Thursday. (reuters.com)
  • The deadly African swine fever disease is much more severe than officially reported in China, leading to the death or killing of as many as half of the country's breeding pigs, according to some estimates in the industry. (reuters.com)
  • In the study, both low and high doses of the vaccine were 100% effective against the virus when the pigs were challenged 28 days post-inoculation. (eurekalert.org)
  • Pigs were initially domesticated in North Africa and Eurasia. (wikipedia.org)
  • In the acute form of the disease caused by highly virulent strains, pigs may develop a high fever, but show no other noticeable symptoms for the first few days. (wikipedia.org)
  • African swine fever (ASF) is an infectious transboundary disease of domestic pigs and wild swine and is currently the most serious constraint to piggery in Uganda. (hindawi.com)
  • African swine fever (ASF) is a viral hemorrhagic disease of both domestic pigs and different species of wild swine [ 1 ]. (hindawi.com)
  • In this study, we set out to identify the African swine fever virus genotypes isolated from an outbreak in domestic pigs from two farms located in the outskirts (suburbs) of Kampala city so as to contribute sequence data for molecular epidemiology studies and to provide further understanding into ASF disease outbreak patterns by mapping of viral genotypes to geographical regions they circulate within. (hindawi.com)
  • The disease is endemic to Africa and Eastern Europe and is rapidly emerging into Asia, where it has led to the deaths of millions of pigs in the last 12 months. (asm.org)
  • Attenuated viruses have proven protective following short immunization protocols in which pigs were challenged a few weeks after the first immunization. (asm.org)
  • African swine fever virus (AFSV), a large enveloped double-stranded DNA virus, causes a deadly infection in domestic pigs. (asm.org)
  • African swine fever (ASF), caused by African swine fever virus, is a hemorrhagic and often fatal disease of domestic pigs and wild boar, which is notifiable to the World Organization for Animal Health. (bioportfolio.com)
  • African swine fever virus causes a haemorrhagic fever in domestic pigs and wild boar. (bioportfolio.com)
  • Correction: Quantitative approach for the risk assessment of African swine fever and Classical swine fever introduction into the United States through legal imports of pigs and swine products. (bioportfolio.com)
  • The outbreak of respiratory illnesses in Mexico that began in March 2009 was caused by a swine origin influenza A (H1N1) virus (S-OIV) that had not been recognized previously in pigs or hu. (bioportfolio.com)
  • African swine fever (ASF) is a highly infectious hemorrhagic viral disease that wipes out entire herds of infected pigs. (idrc.ca)
  • With an estimated 34 million pigs in sub-Saharan Africa, the development of an African swine fever vaccine could benefit up to 17 million smallholder farmers, especially women. (idrc.ca)
  • The U.S. Department of Agriculture's Agricultural Research Service (ARS) today announced that an African Swine Fever Virus vaccine candidate has been adapted to grow in a cell line, which means that those involved in vaccine production will no longer have to rely on live pigs and their fresh cells for vaccine production. (phys.org)
  • African Swine Fever is not a threat to humans and cannot be transmitted from pigs to humans. (phys.org)
  • The continuous cell line vaccine candidate was tested in a commercial breed of pigs and determined to be safe, protecting pigs against the virus. (phys.org)
  • African swine fever (ASF) is a devastating hemorrhagic disease of pigs with mortality rates up to 100% in infected pig herds. (jcvi.org)
  • Symptoms include a hemorrhagic fever that increases in intensity until the infected pigs lose their appetite and die. (neogen.com)
  • The virus has a high fatality rate in pigs, but it doesn't affect humans or any other animals. (neogen.com)
  • Nine pigs were inoculated by intramuscular injection with 10 4 50 per cent hem-adsorbing doses of virus (genotype II) distributed in Armenia and Georgia. (thepigsite.com)
  • It is a tough, long-lived virus that has contaminated pigs, pig production and processing facilities, the surrounding environment plus the pork supply in much of Southeast Asia. (nationalhogfarmer.com)
  • It cannot be tested, but a fair question is if a million pigs each ingested one live virus, can we reliably say no pig would be infected? (nationalhogfarmer.com)
  • The head of the Department of Agriculture (DA), William Dar, blamed hog traders transporting infected pigs for the rising number of African swine fever cases in the country, as per a Philippine Daily Inquirer report. (efeedlink.com)
  • According to DA officials, the virus may have been brought to local farms via swill (food scraps) fed to pigs that had contaminated imported pork products and sourced from hotels and restaurants. (efeedlink.com)
  • While the African swine fever poses no risk to human health, it is fatal and highly contagious for pigs, with no known cure. (efeedlink.com)
  • African swine fever is a highly contagious and severe haemorrhagic viral disease of domestic pigs. (cgiar.org)
  • The present study aimed at investigating the genetic diversity of African swine fever virus strains in symptomatic pigs in South Kivu province of the Democratic Republic of Congo. (cgiar.org)
  • African swine fever, a highly contagious haemorrhagic disease, affects domestic pigs in the Democratic Republic of Congo where regular outbreaks are reported leading to high mortality rates approaching 100% in the affected regions. (cgiar.org)
  • The virus that infects domestic pigs and wild boars has devastated the swine industry in several countries, including in southern Europe. (rappler.com)
  • "Kung nakalusot po ito at naipakain sa mga alagang baboy ang tira-tira maaring kumalat ang sakit sa ating mga babuyan at magiging sanhi ng pagkasira ng ating hog industry (If this got through and the scraps were fed to pigs here, the virus would spread and would lead to the devastation of our hog industry)," he said. (rappler.com)
  • African swine fever (ASF) is a devastating haemorrhagic viral disease with a mortality approaching 100% among naïve domestic pigs and currently there is no vaccine available. (essays.se)
  • African swine fever (ASF) is an economically significant haemorrhagic disease of domestic pigs. (up.ac.za)
  • This test allows farmers to string a rope in the pen, the pigs will naturally chew on the rope and then the rope can be tested to detect for traces of targeted viruses. (kticradio.com)
  • They are also working with ViroVet to produce ASF antivirals that could lower virus replication in pigs and limit clinical signs, which would form an important part of any feed-based strategy to control the virus. (pirbright.ac.uk)
  • Blome S , Gabriel C , Beer M . Pathogenesis of African swine fever in domestic pigs and European wild boar. (microbiologyresearch.org)
  • Evaluation of hemostaseological status of pigs experimentally infected with African swine fever virus. (microbiologyresearch.org)
  • In the absence of a vaccine, antiviral drugs could provide an alternative control method which would help limit clinical signs in pigs and lower virus replication. (star-idaz.net)
  • African swine fever (ASF) is a viral disease that only domestic pigs and wild boar are susceptible to. (wur.nl)
  • Domestic pigs and the wild boar (Sus scrofa) are also susceptible to this virus. (wur.nl)
  • OIE), causes an acute hemorrhagic fever in domestic pigs. (cdc.gov)
  • Results of the analysis showed that the Georgia from domestic pigs or from wildlife hosts in eastern and isolates group within genotype II, which suggests that the southern Africa. (cdc.gov)
  • African swine fever (ASF) is a severe haemorrhagic fever in domestic pigs and wild boar with extremely high mortality rate. (virosin.org)
  • It is unlikely that food infected with African swine fever virus will cause an outbreak in Japan unless pigs in the country are fed with infected food. (japannews.top)
  • Both African and classical swine fevers pose no direct threat to human health as they are diseases of domesticated pigs and wild boars, but infections can be devastating to the farm industry. (japannews.top)
  • Officials have highlighted the need for a quick response to the situation because wild boars could possibly spread the virus to pigs being raised for human consumption. (koreabizwire.com)
  • Natural News ) One third of all the pigs in China are either dead from African Swine Fever or have been executed by farmers in fear of the deadly virus spreading among other close-quarter pigs. (naturalnews.com)
  • Besides running a high fever, the pigs develop skin lesions and go into convulsions from Swine Fever, and then they're dead within two weeks, especially the young ones. (naturalnews.com)
  • What causes Swine Fever Virus in pigs, and how does it spread so easily and so quickly? (naturalnews.com)
  • Swine Fever Virus begins when farmers feed their pigs infected pigs. (naturalnews.com)
  • Even healthy pigs can incubate the virus infection, or they could have already beaten it and survived, but still be excreting it for quite some time, infecting all those pigs around it, that are most likely wallowing in feces when they're not eating their cannibalistic meals. (naturalnews.com)
  • China is literally shipping and smuggling inside disguised containers the very virus that's wiped out a third of their pigs. (naturalnews.com)
  • Pigs were also reported dead in Bach Thuong and Chuyen Ngoai communes, Duy Tien district with the virus suspected as the cause. (vietnamplus.vn)
  • African swine fever (ASF) is a contagious viral disease that causes a lethal, hemorrhagic fever in domestic pigs and wild boar. (emu.ee)
  • The ends of African swine fever virus genome are formed by a 37 nucleotide-long hairpin loop composed, almost entirely, of incompletely paired A and T residues. (nih.gov)
  • It is the only virus with a double-stranded DNA genome known to be transmitted by arthropods. (wikipedia.org)
  • The virus encodes enzymes required for replication and transcription of its genome, including elements of a base excision repair system, structural proteins, and many proteins that are not essential for replication in cells, but instead have roles in virus survival and transmission in its hosts. (wikipedia.org)
  • Continuous virus characterization enhances the understanding of ASF epidemiology in terms of viral genome variations, extent, severity, and the potential source of the viruses responsible for outbreaks. (hindawi.com)
  • Intragenotypic resolution of the CVR region revealed major deletions in the virus genome, in some isolates of this study. (hindawi.com)
  • African swine fever viral genome has around 170 to 195kbp depending on the isolate [ 9 ]. (hindawi.com)
  • The analysis of variable regions of African swine fever virus genome led to more genotypic and serotypic information about circulating strains. (cgiar.org)
  • No study on the characteristics of the complete genome of strains responsible for African swine fever outbreaks in the South Kivu province of DRC is available, limited a better understanding of molecular evolution and spread of this virus within the country. (cgiar.org)
  • Therefore, this study aimed at determining the complete genome sequence of African swine fever virus strains genotype X involved in the 2018-2019 African swine fever outbreaks in South Kivu province of the Democratic Republic of Congo. (cgiar.org)
  • Dixon, L. K. 2006-12-01 00:00:00 Variable regions of the African swine fever virus genome, which contain arrays of tandem repeats, were compared in the genomes of isolates obtained over a 40-year period. (deepdyve.com)
  • Comparison of the size of products generated by polymerase chain reaction (PCR) from four different genome regions, within the B602L and KP86R genes and intergenic regions J286L and BtSj, placed 43 closely related isolated from Europe, the Caribbean, West and Central Africa into 17 different virus sub-groups. (deepdyve.com)
  • All samples were negative for virus genome presence and positive for the tick genome target. (up.ac.za)
  • Chapman DAG, Tcherepanov V, Upton C, Dixon LK (2008)Comparison of the genome sequences of nonpathogenic and pathogenic African swine fever virus isolates. (virosin.org)
  • Complete genome sequence of an African swine fever virus isolate from Sardinia, Italy. (pacb.com)
  • Thus, the rebound could be attributed to host immune response to yellow fever virus Comparative Analysis of rather than to another pathogen or to direct effects of the vi- Whole-Genome Sequence of rus itself. (cdc.gov)
  • Screening test for neutralizing antibodies against yellow fever virus, based on a We analyzed the whole-genome sequence of African swine flavivirus pseudotype. (cdc.gov)
  • Apart from this, viruses in the realm also share many other characteristics, such as minor capsid proteins (mCP) with the vertical jelly roll fold, an ATPase that packages viral DNA into the capsid, and a DNA polymerase that replicates the viral genome. (wikipedia.org)
  • The exact function of the ATPase for some viruses in Varidnaviria is unclear since morphological features, such as the circular, supercoiled genome of Pseudoalteromonas virus PM2, seemingly prohibit translocation by the ATPase of DNA from outside the capsid to the inside. (wikipedia.org)
  • African swine fever virus genotype X and serogroup 7 was identified in the African swine fever disease outbreaks in South Kivu province of DRC in 2018-2019. (cgiar.org)
  • Dixon LK, Sun H, Roberts H (2019) African swine fever. (virosin.org)
  • 2019). African swine fever (infection with African swine fever virus) Manual of Diagnostic Tests and Vaccines for Terrestrial Animals . (cdc.gov)
  • Varidnaviria was established in 2019 based on the shared characteristics of the viruses in the realm. (wikipedia.org)
  • The number of genes differs slightly among different isolates of the virus. (wikipedia.org)
  • Sequence analysis of the most variable fragment, within the B602L gene, from 81 different isolates distinguished 31 sub-groups of virus isolates which varied in sequence and number of a tandem repeat encoding 4 amino acids. (deepdyve.com)
  • The methods could be used in future to study the epidemiology and evolution of virus isolates and to trace the sources of disease outbreaks. (deepdyve.com)
  • Previous genetic characterization of African swine fever virus isolates from the Italian island of Sardinia, where the virus has been present since 1978, has largely been limited to a few selected genomic regions. (pacb.com)
  • A Long-Term Study of the Biological Properties of ASF Virus Isolates Originating from Various Regions of the Russian Federation in 2013-2018. (cdc.gov)
  • Genetic characterization of African swine fever virus in Cameroon, 2010-2018. (bioportfolio.com)
  • In September 2018 the virus made a big leap and hundreds of wild boars in our neighbouring country became infected. (wur.nl)
  • fever virus Belgium 2018/1. (cdc.gov)
  • Phylogeographic Analysis of African Swine Fever Virus, Western Europe, 2018. (cdc.gov)
  • The existence of overlapping nuclear export mechanisms, together with our observation that p37 protein is localized in the nucleus at early stages of infection and exclusively in the cytoplasm at later stages, suggests that the nuclear transport ability of this protein may be critical to the African swine fever virus replication cycle. (nih.gov)
  • The team demonstrated that genes expressed during early infection have different promoters to those expressed later, allowing the virus to shift the pattern of activated genes according to the stage of infection. (pig-world.co.uk)
  • Genes used for DNA replication and immune system evasion are switched on early in the infection cycle, whereas those involved in creating proteins for the new virus particles are activated later. (pig-world.co.uk)
  • Our study helps to untangle which genes are important during different stages of infection to better understand their functions", said Dr Linda Dixon, Head of the African Swine Fever Virus Group at Pirbright. (pig-world.co.uk)
  • The rates of infection and deaths due to the virus are very high and lack a proper cure or vaccine. (koreabizwire.com)
  • Recently moderate-virulence classical swine fever virus (CSFV) strains have been proven capable of generating postnatal persistent infection (PI), defined by the maintenance of viremia and the inability to generate CSFV-specific immune responses in animals. (beds.ac.uk)
  • This was the first outbreak in recent history outside of Africa and Sardinia--where swine fever is endemic--and this particular strain has been highly lethal and highly contagious, spreading quickly to neighboring countries. (eurekalert.org)
  • Since its first description in Kenya [ 4 ], the disease has been reported in various countries around the world, recently in China, but remaining endemic in Sardinia, East Africa, and Southern Africa, where it represents a major threat for development of the pig industry [ 5 , 6 ]. (hindawi.com)
  • ASF is presently endemic in a greater part of sub-Saharan Africa with the island of Madagascar inclusive [ 7 ], where it is maintained by both a sylvatic cycle involving ticks associated with wild suids and a domestic cycle involving direct pig to pig transmission in different regions [ 8 ]. (hindawi.com)
  • Disease is endemic in domestic swine in many African countries and Sardinia. (bioportfolio.com)
  • Argasid ticks of the genus Ornithodoros, which are widely distributed throughout southern Africa, play a primary role in virus maintenance and spread within the endemic sylvatic cycle. (up.ac.za)
  • and to the giant forest hog (Hylochoerus meinertzhageni), all of which are endemic to Africa. (wur.nl)
  • Over recent years we have seen the virus being found increasingly in wild boar, and it seems that under certain circumstances, the virus can continue to circulate among wild boar over the longer term or even become endemic. (wur.nl)
  • Centre de Coopéra- with the exception of Sardinia, where ASF has remained tion Internationale en Recherche Agronomique pour le Développe- endemic since 1982 ( 1 ). (cdc.gov)
  • CSF remains endemic in areas of Asia, Europe, Central and South America and parts of Africa. (beds.ac.uk)
  • HONG KONG/BEIJING (Reuters) - China reported another outbreak of deadly African swine fever late on Monday, its third new case in two days, as the highly contagious disease spreads rapidly through the world's top pork producer. (reuters.com)
  • Even though the virus is not currently present in the United States, the U.S. swine industry could suffer substantial economic losses should an outbreak occur. (usda.gov)
  • The research was motivated by the 2007 outbreak of African swine fever in the Republic of Georgia, said principal investigator Douglas P. Gladue, PhD, Senior Scientist, Plum Island Animal Disease Center, Agricultural Research Service, US Department of Agriculture. (eurekalert.org)
  • The 2007 outbreak was also the genesis of the African swine fever that has been spreading through Eastern Europe and east Asia, said Manuel V. Borca, PhD, also a Senior Scientist at the Plum Island Animal Disease Center. (eurekalert.org)
  • It's important to have the right diagnostic tools available to get an outbreak under control, and our tools can help China's diagnostic laboratories rapidly determine if ASF virus is on a farm so pig farmers and veterinarians can take appropriate action against further spread of the virus," Martin Guillet, global head and general manager for AgriBusiness at Thermo Fisher Scientific. (thepigsite.com)
  • Understanding how African swine fever survives can help us create better techniques for controlling the spread of this costly virus and reduce the odds of a domestic outbreak. (kticradio.com)
  • U.S. Pork producers are already coping with uncertainty across the entire sector and an outbreak of African Swine Fever would devastate American farmers, who are already struggling. (kticradio.com)
  • Genetic characterization of African swine fever viruses from a 2008 outbreak in Tanzania. (semanticscholar.org)
  • SEOUL, Sept. 14 (Korea Bizwire) - Government officials will be beefing up efforts to prevent the influx of African swine fever virus from China, where a recent outbreak of the virus was reported. (koreabizwire.com)
  • Is the U.S. ready to lose $30 - $50 billion a year due to a swine virus outbreak? (naturalnews.com)
  • An outbreak of African Swine Fever has been reported in the Tselinskii area of Russia's Rostov region. (pigprogress.net)
  • Genotype I has been circulating in Europe, South America, the Caribbean, and western Africa. (wikipedia.org)
  • Genotype VIII is confined to four East African countries. (wikipedia.org)
  • This represents the first report of African swine fever virus genotype X in the Democratic Republic of Congo. (cgiar.org)
  • We have identified a cell-line that can be used to isolate and detect the presence of the live virus," said ARS Scientist Dr. Douglas Gladue . (usda.gov)
  • Outbreaks of this disease are devastating the swine industry from Central Europe to East Asia, and they are being caused by circulating strains of African swine fever virus derived from the Georgia 2007 isolate. (asm.org)
  • Here, we report the discovery of a previously uncharacterized virus gene, which when deleted completely attenuates the Georgia isolate. (asm.org)
  • Simultaneous Deletion of the 9GL and UK Genes from the African Swine Fever Virus Georgia 2007 Isolate Offers Increased Safety and Protection against Homologous Challenge. (cdc.gov)
  • Production of backyard swine industry decreased by almost half, from 1,119 tons of pork in 2007 to 608 tons of pork in 2017 ( 5 ). (cdc.gov)
  • African swine fever outbreaks in Russia and countries in eastern Europe, 2017. (cdc.gov)
  • This provided additional information about strains of viruses circulating in different countries. (deepdyve.com)
  • Bastos ADS, Penrith ML, Cruciere C, Edrich JL, Hutchings G, Roger F, Couacy-Hymann E, Thomson GR (2003) Genotyping field strains of African swine fever virus by partial p72 gene characterisation. (virosin.org)
  • Currently, there is no commercially available vaccine against African swine fever, which has been devastating the swine industry in Eastern Europe and Southeast Asia. (eurekalert.org)
  • African swine fever (ASF) is a highly contagious and devastating pig disease that has caused extensive global economic losses. (researchsquare.com)
  • Highly contagious African swine fever virus has been detected in the luggage of a traveler from China at a Hokkaido airport, Japan's farm ministry said Monday. (japannews.top)
  • Heartwater and contagious caprine pleuropneumonia (CCCP) are two diseases that constitute major threats to small ruminant (grazing animals such as goats and sheep) production in developing countries, notably in Africa. (idrc.ca)
  • In common with other viral hemorrhagic fevers, the main target cells for replication are those of monocyte, macrophage lineage. (wikipedia.org)
  • Virus replication takes place in perinuclear factory areas. (wikipedia.org)
  • The majority of replication and assembly occurs in discrete, perinuclear regions of the cell called virus factories, and finally progeny virions are transported to the plasma membrane along microtubules where they bud out or are propelled away along actin projections to infect new cells. (wikipedia.org)
  • In vivo replication of African swine fever virus (Malawi '83) in neutrophils. (microbiologyresearch.org)
  • Dixon LK, Chapman DAG, Netherton CL, Upton C (2013) African swine fever virus replication and genomics. (virosin.org)
  • They used a predictive methodology called a computational pipeline to predict the roles of proteins on the virus. (eurekalert.org)
  • The virus encodes proteins that inhibit signalling pathways in infected macrophages and thus modulate transcriptional activation of immune response genes. (wikipedia.org)
  • In addition, the virus encodes proteins which inhibit apoptosis of infected cells to facilitate production of progeny virions. (wikipedia.org)
  • Viral membrane proteins with similarity to cellular adhesion proteins modulate interaction of virus-infected cells and extracellular virions with host components. (wikipedia.org)
  • Neutralizing antibodies to African swine fever virus proteins p30, p54, and p72 are not sufficient for antibody-mediated protection. (cdc.gov)
  • Varidnaviria is a realm of viruses that includes all DNA viruses that encode major capsid proteins that contain a vertical jelly roll fold. (wikipedia.org)
  • Most viruses in Varidnaviria contain a capsid that is made of major capsid proteins that contain vertical single (SJR) or double jelly roll (DJR) folds. (wikipedia.org)
  • Washington, DC - January 23, 2020 - Government and academic investigators have developed a vaccine against African swine fever that appears to be far more effective than previously developed vaccines. (eurekalert.org)
  • Part of the process of developing whole virus vaccines involves deleting virulence genes from the virus. (eurekalert.org)
  • By adopting this cutting-edge approach to the development of African swine fever vaccines, the overall expected result is the generation of a vaccine candidate that will undergo further testing and if successful, be produced as a new vaccine for ASF. (idrc.ca)
  • No commercial vaccines are currently available to prevent the virus from spreading. (phys.org)
  • When the African swine fever virus was first discovered, researchers began to develop inactivated vaccines. (creative-biolabs.com)
  • We provide a comprehensive range of viral vaccines development for swine fever virus vaccine project. (creative-biolabs.com)
  • Virus production for vaccines is still a challenging issue, particularly with slow-growing viruses such as influenza. (idrc.ca)
  • Approaches and Perspectives for Development of African Swine Fever Virus Vaccines. (cdc.gov)
  • Since emerging in the early 1900s from East Africa, ASF has moved through sub-Saharan Africa and on two occasions has entered European countries. (pirbright.ac.uk)
  • By the mid-1990s, the virus had been eradicated everywhere outside of Africa, with the exception of the Italian island of Sardinia. (wur.nl)
  • African Swine Fever is known to cause virulent, deadly outbreaks in wild and domestic swine, causing widespread and lethal outbreaks in various countries in Eastern Europe and throughout Asia. (phys.org)
  • Delayed notification of clinical signs in swine premises or introduction of a low-virulent strain cannot be excluded. (actipro.biz)
  • So far, 22 genotypes have been identified with several of them currently co-circulating in Sub-Saharan Africa. (biomedcentral.com)
  • Nuclear export of African swine fever virus p37 protein occurs through two distinct pathways and is mediated by three independent signals. (nih.gov)
  • Nucleocytoplasmic shuttling activity of the African swine fever virus p37 protein, a major structural protein of this highly complex virus, has been recently reported. (nih.gov)
  • African swine fever virus encodes a serine protein kinase which is packaged into virions. (ox.ac.uk)
  • This ORF encodes a 35.1-kDa protein of 299 amino acids which shares 24.6% amino acid identity with the human pim-1 proto-oncogene and 21.0% identity with the vaccinia virus B1R-encoded protein kinase. (ox.ac.uk)
  • All viruses in Varidnaviria that encode a DJR-MCP that have been analyzed in high resolution also encode a minor capsid protein (mCP) that contains an SJR fold. (wikipedia.org)
  • This discovery, highlighted in the Journal of Virology , overcomes one of the major challenges for manufacturing of an African Swine Fever Virus vaccine. (phys.org)
  • A cell culture-adapted vaccine virus against the current pandemic African swine fever virus strain, Journal of Virology (2021). (phys.org)
  • African swine fever (ASF) is a highly lethal haemorrhagic disease in domestic and wild swine that has acquired great importance in sub-Saharan Africa since 1997. (bioportfolio.com)
  • The in vitro specificity of the CD8 + T-cells present at the time of lethal challenge showed a clear activation against the homologous virus (E75) but not against BA71. (biomedcentral.com)
  • African swine fever is regarded as more lethal than conventional swine fever, also known as hog cholera, and there is no effective vaccine to protect swine from the deadly pig disease. (japannews.top)
  • Whilst this first evaluation of ASF presence in Swaziland indicates that the virus does not appear to be present in the key virus vector, the presence of sylvatic cycle hosts, together with the country's proximity to ASF-affected countries calls for expanded investigations and regular monitoring of the ASF status of Swaziland. (up.ac.za)
  • The Ministry of Environment announced yesterday that it had set up a task force in charge of carrying out efforts to prevent the spread of African swine fever virus via wild boars. (koreabizwire.com)
  • However, authorities have stated that the likelihood of wild boars infected with the virus in China entering national borders and spreading the disease in South Korea was minimal. (koreabizwire.com)
  • The National Institute of Environmental Research will be capturing 800 wild boars yearly, up from the previous 300, to carry out checks for viruses and other illnesses. (koreabizwire.com)
  • In the case of African swine fever virus vaccine candidates, this issue has received little attention. (asm.org)
  • Traditionally we used freshly isolated swine cells to produce vaccine candidates and this constitutes a significant limitation for large-scale production" said senior ARS scientist Dr. Douglas Gladue. (phys.org)
  • A major roadblock has been the lack of convenient genetic tools to study this pathogen, with periods of up to a year of labor intensive effort just to generate one or two modified viruses, let alone to generate attenuated vaccine candidates. (jcvi.org)
  • The virus is thought to be derived from a virus of soft tick (genus Ornithodoros) that infects wild swine, including giant forest hogs (Hylochoerus meinertzhageni), warthogs (Phacochoerus africanus), and bushpigs (Potamochoerus porcus). (wikipedia.org)
  • It is the only DNA virus known that is able to infect arthropods (certain soft-bodied ticks of the genus Ornithodoros), as well as mammals. (wur.nl)
  • It is transmitted between domestic swine by direct contact, ingestion of infected meat, or fomites, or mechanically by biting flies or soft ticks (genus Ornithodoros). (pozzter.com)
  • The subset of the FtsK-HerA superfamily found in Varidnaviria is often called the A32 clade, named after the ATPase-encoding A32(R) gene of Vaccinia virus. (wikipedia.org)
  • Sequencing of the complete p54 gene has been shown by earlier studies to offer additional, intermediate resolution when typing the ASF viruses [ 17 ]. (hindawi.com)
  • Nucleotide sequencing of the latter confirmed that Ornithodoros ticks from Swaziland are identical to those from the Kruger National Park in South Africa across the gene region characterised. (up.ac.za)
  • A nonessential African swine fever virus gene UK is a significant virulence determinant in domestic swine. (cdc.gov)
  • The African swine fever (ASF) virus is the sole member of the Asfarviridae family. (wur.nl)
  • The family Asfarviridae belongs to the member of nucleocytoplasmic large DNA viruses (NCLDV) superfamily (Iyer et al . (virosin.org)
  • The swine and feed industry have experienced significant pressure to enhance biosecurity practices in recent years, with initial focus developing after the introduction of porcine epidemic diarrhea virus into North America. (nationalhogfarmer.com)
  • Sanchez-Vizcaino JM, Mur L, Gomez-Villamandos JC, Carrasco L (2015) An update on the epidemiology and pathology of African swine fever. (virosin.org)
  • Trends in Emerging Viral Infections of Swine includes sections on global trade, vaccination regimens against new and emerging viruses, epidemiology and control, as well as significant new outbreaks like the West Nile virus. (wiley.com)
  • The Epidemiology of African Swine Fever in "Nonendemic" Regions of Zambia (1989-2015): Implications for Disease Prevention and Control. (cdc.gov)
  • We remain committed to investing Pork Checkoff funds in strategic ways, such as this collaboration to find new ways to protect our domestic swine herd from foreign animal disease threats," said David Newman, president of the National Pork Board and a producer representing Arkansas. (kticradio.com)
  • No domestic case of infections with African swine fever virus has been reported thus far. (japannews.top)
  • With recent evidence that feed could also serve as a means for transmission of foreign animal diseases such as African swine fever virus, a renewed emphasis has been placed on continued improvement of biosecurity practices implemented within the swine feed sector. (nationalhogfarmer.com)
  • A contributor to Diseases of Swine, 8th edition, Dr. Zimmerman has selected three additional editors with international expertise. (wiley.com)
  • The warthog and the soft-bodied tick (mainly of the species Ornithodoros moubata) maintain the virus cycle there. (wur.nl)
  • The virus is spread only by species of animals belonging to the wild boar category. (koreabizwire.com)
  • TWiV provides updates on the new coronavirus causing respiratory disease in China, the current influenza season, and the epidemic of African swine fever, including determination of the three-dimensional structure of the virus particle. (microbe.tv)
  • Swine Influenza Virus. (wiley.com)
  • This disease is caused by a large double-stranded DNA virus with an icosahedral symmetry. (hindawi.com)
  • African swine fever (ASF) poses a major threat to pig populations and food security worldwide. (asm.org)
  • The continuing spread of African swine fever (ASF) outside Africa in Europe, the Russian Federation, China and most recently to Mongolia and Vietnam, has heightened awareness of the threat posed by th. (bioportfolio.com)
  • Now, that work may help to fend off the threat from the African Swine Fever virus. (farms.com)
  • In 2007 the virus re-entered Europe through Georgia and since then it has spread to East-Europe, becoming a real threat for all Europe. (biomedcentral.com)
  • Could air passenger luggage be a threat with regard to the importing of Classical or African Swine Fever into. (pigprogress.net)
  • The virus is transmitted by ticks and direct contact between animals, and can also travel via contaminated food, animal feed and people moving from one place to another. (reuters.com)
  • The ASF has periodically been reported in most parts of the world including Western Europe and outside Africa, where ASF was eventually eradicated in most cases by the slaughter of infected and in-contact animals, safe carcass disposal, good sanitation, disinfection, quarantine, and the prevention of contact with wild suids and infected ticks. (hindawi.com)
  • Warthogs and soft ticks are considered natural reservoirs of the virus and do not show clinical illness. (essays.se)
  • Virus- DNA was detected in two ticks from two burrows in Murchison Falls NP using a commercial realtime PCR when performed in Uganda. (essays.se)
  • Certain ticks can also become infected with the virus. (wur.nl)
  • Soft-bodied ticks feed on infected warthogs, propagate the virus and pass it on to another warthog at their next blood meal. (wur.nl)
  • As warthogs and ticks cohabit closely in warthog burrows, this is an efficient method of spreading the virus. (wur.nl)
  • Bovine babesiosis is a protozoan disease of cattle, water, and African buffaloes and is caused by Babesia bovis, a parasite transmitted by ticks. (idrc.ca)
  • The deadly SFV has already shown up in Eastern Europe and Russia and devastated entire sounders and litters of swine. (naturalnews.com)
  • ASF is widespread in at least half of sub-Saharan Africa, and threatens food security due to devastating economic losses. (idrc.ca)
  • It is prevalent in many sub-Saharan African countries, causing major economic losses and threatening food security. (jcvi.org)
  • Bovine tuberculosis is a devastating disease of cattle responsible for major economic losses in Africa and Asia. (idrc.ca)
  • The disease is characterized by an acute form that leads to fever, hemorrhages and several lesions causing death in a short period of time. (biomedcentral.com)
  • scribed liver cytolysis during yellow fever as being acute, 9. (cdc.gov)
  • It is the causative agent of African swine fever (ASF). (wikipedia.org)
  • Alonso, C. Analysis of HDAC6 and BAG3-Aggresome Pathways in African Swine Fever Viral Factory Formation. (mdpi.com)
  • Interestingly, the kinetics of both viruses not only differed on the clinical signs that they caused and in the virus loads found, but also in the immunological pathways activated throughout the infections. (biomedcentral.com)
  • All these miRNAs have been shown to be associated with cellular genes involved in pathways related to the immune response, virus-host interactions as well as with several viral genes. (biomedcentral.com)
  • Tesis doctoral inédita leída en la Universidad Autónoma de Madrid, Facultad de Ciencias, Departamento de Biología Molecular. (uam.es)
  • In East and Central Africa, the most important tick-borne disease of livestock is East Coast fever, caused by the intracellular parasite Theileria parva. (idrc.ca)
  • African swine fever (ASF) is widespread in Africa but is rarely introduced to other continents. (up.ac.za)
  • African swine fever (ASF) is widespread in Africa but diagnosis of the disease and culling of infected animals and is rarely introduced to other continents. (cdc.gov)
  • The disease was first described in 1921, in Africa. (wur.nl)
  • ASF was first described in 1921 in Kenya [ 3 ] spreading rapidly throughout other African countries. (biomedcentral.com)
  • In this current work, we have investigated the role of the African swine fever virus (AFSV) in the context of autophagy and in the innate immune response of the host cell. (uam.es)