Mannosidase Deficiency Diseases: Diseases caused by the loss of one or more enzymes involved in the hydrolysis of mannoside linkages (MANNOSIDASES). The defects in enzyme activity are primarily associated with genetic mutation of the genes that codes for a particular mannosidase isoenzyme.Carbamoyl-Phosphate Synthase I Deficiency Disease: A urea cycle disorder manifesting in infancy as lethargy, emesis, seizures, alterations of muscle tone, abnormal eye movements, and an elevation of serum ammonia. The disorder is caused by a reduction in the activity of hepatic mitochondrial CARBAMOYL-PHOSPHATE SYNTHASE (AMMONIA). (Menkes, Textbook of Child Neurology, 5th ed, pp50-1)Immunologic Deficiency Syndromes: Syndromes in which there is a deficiency or defect in the mechanisms of immunity, either cellular or humoral.Multiple Sulfatase Deficiency Disease: An inherited metabolic disorder characterized by the intralysosomal accumulation of sulfur-containing lipids (sulfatides) and MUCOPOLYSACCHARIDES. Excess levels of both substrates are present in urine. This is a disorder of multiple sulfatase (arylsulfatases A, B, and C) deficiency which is caused by the mutation of sulfatase-modifying factor-1. Neurological deterioration is rapid.Pyruvate Carboxylase Deficiency Disease: An autosomal recessive metabolic disorder caused by absent or decreased PYRUVATE CARBOXYLASE activity, the enzyme that regulates gluconeogenesis, lipogenesis, and neurotransmitter synthesis. Clinical manifestations include lactic acidosis, seizures, respiratory distress, marked psychomotor delay, periodic HYPOGLYCEMIA, and hypotonia. The clinical course may be similar to LEIGH DISEASE. (From Am J Hum Genet 1998 Jun;62(6):1312-9)Pyruvate Dehydrogenase Complex Deficiency Disease: An inherited metabolic disorder caused by deficient enzyme activity in the PYRUVATE DEHYDROGENASE COMPLEX, resulting in deficiency of acetyl CoA and reduced synthesis of acetylcholine. Two clinical forms are recognized: neonatal and juvenile. The neonatal form is a relatively common cause of lactic acidosis in the first weeks of life and may also feature an erythematous rash. The juvenile form presents with lactic acidosis, alopecia, intermittent ATAXIA; SEIZURES; and an erythematous rash. (From J Inherit Metab Dis 1996;19(4):452-62) Autosomal recessive and X-linked forms are caused by mutations in the genes for the three different enzyme components of this multisubunit pyruvate dehydrogenase complex. One of the mutations at Xp22.2-p22.1 in the gene for the E1 alpha component of the complex leads to LEIGH DISEASE.Deficiency Diseases: A condition produced by dietary or metabolic deficiency. The term includes all diseases caused by an insufficient supply of essential nutrients, i.e., protein (or amino acids), vitamins, and minerals. It also includes an inadequacy of calories. (From Dorland, 27th ed; Stedman, 25th ed)Ornithine Carbamoyltransferase Deficiency Disease: An inherited urea cycle disorder associated with deficiency of the enzyme ORNITHINE CARBAMOYLTRANSFERASE, transmitted as an X-linked trait and featuring elevations of amino acids and ammonia in the serum. Clinical features, which are more prominent in males, include seizures, behavioral alterations, episodic vomiting, lethargy, and coma. (Menkes, Textbook of Child Neurology, 5th ed, pp49-50)Vitamin A Deficiency: A nutritional condition produced by a deficiency of VITAMIN A in the diet, characterized by NIGHT BLINDNESS and other ocular manifestations such as dryness of the conjunctiva and later of the cornea (XEROPHTHALMIA). Vitamin A deficiency is a very common problem worldwide, particularly in developing countries as a consequence of famine or shortages of vitamin A-rich foods. In the United States it is found among the urban poor, the elderly, alcoholics, and patients with malabsorption. (From Cecil Textbook of Medicine, 19th ed, p1179)alpha 1-Antitrypsin Deficiency: Deficiency of the protease inhibitor ALPHA 1-ANTITRYPSIN that manifests primarily as PULMONARY EMPHYSEMA and LIVER CIRRHOSIS.Vitamin B 12 Deficiency: A nutritional condition produced by a deficiency of VITAMIN B 12 in the diet, characterized by megaloblastic anemia. Since vitamin B 12 is not present in plants, humans have obtained their supply from animal products, from multivitamin supplements in the form of pills, and as additives to food preparations. A wide variety of neuropsychiatric abnormalities is also seen in vitamin B 12 deficiency and appears to be due to an undefined defect involving myelin synthesis. (From Cecil Textbook of Medicine, 19th ed, p848)Vitamin D Deficiency: A nutritional condition produced by a deficiency of VITAMIN D in the diet, insufficient production of vitamin D in the skin, inadequate absorption of vitamin D from the diet, or abnormal conversion of vitamin D to its bioactive metabolites. It is manifested clinically as RICKETS in children and OSTEOMALACIA in adults. (From Cecil Textbook of Medicine, 19th ed, p1406)Folic Acid Deficiency: A nutritional condition produced by a deficiency of FOLIC ACID in the diet. Many plant and animal tissues contain folic acid, abundant in green leafy vegetables, yeast, liver, and mushrooms but destroyed by long-term cooking. Alcohol interferes with its intermediate metabolism and absorption. Folic acid deficiency may develop in long-term anticonvulsant therapy or with use of oral contraceptives. This deficiency causes anemia, macrocytic anemia, and megaloblastic anemia. It is indistinguishable from vitamin B 12 deficiency in peripheral blood and bone marrow findings, but the neurologic lesions seen in B 12 deficiency do not occur. (Merck Manual, 16th ed)IgA Deficiency: A dysgammaglobulinemia characterized by a deficiency of IMMUNOGLOBULIN A.Thiamine Deficiency: A nutritional condition produced by a deficiency of THIAMINE in the diet, characterized by anorexia, irritability, and weight loss. Later, patients experience weakness, peripheral neuropathy, headache, and tachycardia. In addition to being caused by a poor diet, thiamine deficiency in the United States most commonly occurs as a result of alcoholism, since ethanol interferes with thiamine absorption. In countries relying on polished rice as a dietary staple, BERIBERI prevalence is very high. (From Cecil Textbook of Medicine, 19th ed, p1171)Glucosephosphate Dehydrogenase Deficiency: A disease-producing enzyme deficiency subject to many variants, some of which cause a deficiency of GLUCOSE-6-PHOSPHATE DEHYDROGENASE activity in erythrocytes, leading to hemolytic anemia.Magnesium Deficiency: A nutritional condition produced by a deficiency of magnesium in the diet, characterized by anorexia, nausea, vomiting, lethargy, and weakness. Symptoms are paresthesias, muscle cramps, irritability, decreased attention span, and mental confusion, possibly requiring months to appear. Deficiency of body magnesium can exist even when serum values are normal. In addition, magnesium deficiency may be organ-selective, since certain tissues become deficient before others. (Harrison's Principles of Internal Medicine, 12th ed, p1936)Anemia, Iron-Deficiency: Anemia characterized by decreased or absent iron stores, low serum iron concentration, low transferrin saturation, and low hemoglobin concentration or hematocrit value. The erythrocytes are hypochromic and microcytic and the iron binding capacity is increased.Vitamin E Deficiency: A nutritional condition produced by a deficiency of VITAMIN E in the diet, characterized by posterior column and spinocerebellar tract abnormalities, areflexia, ophthalmoplegia, and disturbances of gait, proprioception, and vibration. In premature infants vitamin E deficiency is associated with hemolytic anemia, thrombocytosis, edema, intraventricular hemorrhage, and increasing risk of retrolental fibroplasia and bronchopulmonary dysplasia. An apparent inborn error of vitamin E metabolism, named familial isolated vitamin E deficiency, has recently been identified. (Cecil Textbook of Medicine, 19th ed, p1181)Ascorbic Acid Deficiency: A condition due to a dietary deficiency of ascorbic acid (vitamin C), characterized by malaise, lethargy, and weakness. As the disease progresses, joints, muscles, and subcutaneous tissues may become the sites of hemorrhage. Ascorbic acid deficiency frequently develops into SCURVY in young children fed unsupplemented cow's milk exclusively during their first year. It develops also commonly in chronic alcoholism. (Cecil Textbook of Medicine, 19th ed, p1177)Mice, Knockout: Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.Protein C Deficiency: An absence or deficiency in PROTEIN C which leads to impaired regulation of blood coagulation. It is associated with an increased risk of severe or premature thrombosis. (Stedman's Med. Dict., 26th ed.)IgG Deficiency: A dysgammaglobulinemia characterized by a deficiency of IMMUNOGLOBULIN G.Vitamin B 6 Deficiency: A nutritional condition produced by a deficiency of VITAMIN B 6 in the diet, characterized by dermatitis, glossitis, cheilosis, and stomatitis. Marked deficiency causes irritability, weakness, depression, dizziness, peripheral neuropathy, and seizures. In infants and children typical manifestations are diarrhea, anemia, and seizures. Deficiency can be caused by certain medications, such as isoniazid.Factor V Deficiency: A deficiency of blood coagulation factor V (known as proaccelerin or accelerator globulin or labile factor) leading to a rare hemorrhagic tendency known as Owren's disease or parahemophilia. It varies greatly in severity. Factor V deficiency is an autosomal recessive trait. (Dorland, 27th ed)Iron: A metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN.Riboflavin Deficiency: A dietary deficiency of riboflavin causing a syndrome chiefly marked by cheilitis, angular stomatitis, glossitis associated with a purplish red or magenta-colored tongue that may show fissures, corneal vascularization, dyssebacia, and anemia. (Dorland, 27th ed)Amyloid beta-Peptides: Peptides generated from AMYLOID BETA-PEPTIDES PRECURSOR. An amyloid fibrillar form of these peptides is the major component of amyloid plaques found in individuals with Alzheimer's disease and in aged individuals with trisomy 21 (DOWN SYNDROME). The peptide is found predominantly in the nervous system, but there have been reports of its presence in non-neural tissue.Apolipoprotein E3: A 34-kDa glycosylated protein. A major and most common isoform of apolipoprotein E. Therefore, it is also known as apolipoprotein E (ApoE). In human, Apo E3 is a 299-amino acid protein with a cysteine at the 112 and an arginine at the 158 position. It is involved with the transport of TRIGLYCERIDES; PHOSPHOLIPIDS; CHOLESTEROL; and CHOLESTERYL ESTERS in and out of the cells.Apolipoprotein E4: A major and the second most common isoform of apolipoprotein E. In humans, Apo E4 differs from APOLIPOPROTEIN E3 at only one residue 112 (cysteine is replaced by arginine), and exhibits a lower resistance to denaturation and greater propensity to form folded intermediates. Apo E4 is a risk factor for ALZHEIMER DISEASE and CARDIOVASCULAR DISEASES.Alzheimer Disease: A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)Amyloid beta-Protein Precursor: A single-pass type I membrane protein. It is cleaved by AMYLOID PRECURSOR PROTEIN SECRETASES to produce peptides of varying amino acid lengths. A 39-42 amino acid peptide, AMYLOID BETA-PEPTIDES is a principal component of the extracellular amyloid in SENILE PLAQUES.Phenotype: The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.Mice, Transgenic: Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.ArchivesBiological Science Disciplines: All of the divisions of the natural sciences dealing with the various aspects of the phenomena of life and vital processes. The concept includes anatomy and physiology, biochemistry and biophysics, and the biology of animals, plants, and microorganisms. It should be differentiated from BIOLOGY, one of its subdivisions, concerned specifically with the origin and life processes of living organisms.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.Adiponectin: A 30-kDa COMPLEMENT C1Q-related protein, the most abundant gene product secreted by FAT CELLS of the white ADIPOSE TISSUE. Adiponectin modulates several physiological processes, such as metabolism of GLUCOSE and FATTY ACIDS, and immune responses. Decreased plasma adiponectin levels are associated with INSULIN RESISTANCE; TYPE 2 DIABETES MELLITUS; OBESITY; and ATHEROSCLEROSIS.PubMed: A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.Directories as Topic: Lists of persons or organizations, systematically arranged, usually in alphabetic or classed order, giving address, affiliations, etc., for individuals, and giving address, officers, functions, and similar data for organizations. (ALA Glossary of Library and Information Science, 1983)Receptors, Adiponectin: Cell surface receptors for ADIPONECTIN, an antidiabetic hormone secreted by ADIPOCYTES. Adiponectin receptors are membrane proteins with multiple cytoplasmic and extracellular regions. They are about 43 kDa and encoded by at least two genes with different affinities for globular and full-length adiponectin.Hyperlipoproteinemia Type I: An inherited condition due to a deficiency of either LIPOPROTEIN LIPASE or APOLIPOPROTEIN C-II (a lipase-activating protein). The lack of lipase activities results in inability to remove CHYLOMICRONS and TRIGLYCERIDES from the blood which has a creamy top layer after standing.Infectious Disease Medicine: A branch of internal medicine concerned with the diagnosis and treatment of INFECTIOUS DISEASES.Lipoprotein Lipase: An enzyme of the hydrolase class that catalyzes the reaction of triacylglycerol and water to yield diacylglycerol and a fatty acid anion. The enzyme hydrolyzes triacylglycerols in chylomicrons, very-low-density lipoproteins, low-density lipoproteins, and diacylglycerols. It occurs on capillary endothelial surfaces, especially in mammary, muscle, and adipose tissue. Genetic deficiency of the enzyme causes familial hyperlipoproteinemia Type I. (Dorland, 27th ed) EC 3.1.1.34.Exome: That part of the genome that corresponds to the complete complement of EXONS of an organism or cell.Lipase: An enzyme of the hydrolase class that catalyzes the reaction of triacylglycerol and water to yield diacylglycerol and a fatty acid anion. It is produced by glands on the tongue and by the pancreas and initiates the digestion of dietary fats. (From Dorland, 27th ed) EC 3.1.1.3.Hyperlipoproteinemias: Conditions with abnormally elevated levels of LIPOPROTEINS in the blood. They may be inherited, acquired, primary, or secondary. Hyperlipoproteinemias are classified according to the pattern of lipoproteins on electrophoresis or ultracentrifugation.Lipoproteins: Lipid-protein complexes involved in the transportation and metabolism of lipids in the body. They are spherical particles consisting of a hydrophobic core of TRIGLYCERIDES and CHOLESTEROL ESTERS surrounded by a layer of hydrophilic free CHOLESTEROL; PHOSPHOLIPIDS; and APOLIPOPROTEINS. Lipoproteins are classified by their varying buoyant density and sizes.Fetal Growth Retardation: The failure of a FETUS to attain its expected FETAL GROWTH at any GESTATIONAL AGE.Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.Placental Insufficiency: Failure of the PLACENTA to deliver an adequate supply of nutrients and OXYGEN to the FETUS.Journal Impact Factor: A quantitative measure of the frequency on average with which articles in a journal have been cited in a given period of time.Infant, Newborn: An infant during the first month after birth.Placenta: A highly vascularized mammalian fetal-maternal organ and major site of transport of oxygen, nutrients, and fetal waste products. It includes a fetal portion (CHORIONIC VILLI) derived from TROPHOBLASTS and a maternal portion (DECIDUA) derived from the uterine ENDOMETRIUM. The placenta produces an array of steroid, protein and peptide hormones (PLACENTAL HORMONES).Gestational Age: The age of the conceptus, beginning from the time of FERTILIZATION. In clinical obstetrics, the gestational age is often estimated as the time from the last day of the last MENSTRUATION which is about 2 weeks before OVULATION and fertilization.
... deficiency is a rare X-linked disease in which properdin is deficient. Affected individuals are susceptible to ... fulminant meningococcal disease. GRCh38: Ensembl release 89: ENSG00000126759 - Ensembl, May 2017 GRCm38: Ensembl release 89: ...
Deficiency of the nutrient causes disease of the affected organism. In single-cell organisms such as bacteria and yeast, low ... Acute deficiency (see hypomagnesemia) is rare, and is more common as a drug side-effect (such as chronic alcohol or diuretic ... In yeast, mitochondrial magnesium deficiency also leads to disease. Plants deficient in magnesium show stress responses. The ... Ion channels Myers' cocktail Magnesium deficiency (medicine) Magnesium deficiency (agriculture) Calcium In Biology "Magnesium ( ...
The most common LSD is Gaucher's disease, which is due to deficiency of the enzyme glucocerebrosidase. Consequently, the enzyme ... Metachromatic leukodystrophy is another lysosomal storage disease that also affects sphingolipid metabolism. Weak bases with ... which are collectively known as lysosomal storage diseases. These diseases result from an accumulation of specific substrates, ... The organs most affected are brain, viscera, bone and cartilage. There is no direct medical treatment to cure LSDs. ...
Canavan's disease is a white matter disease due to aspartoacylase deficiency. The dentate nucleus is not affected until late in ... Glutaric aciduria type 1 (GA1): An autosomal recessive disease, GA1 is due to glutaryl-coenzyme A dehydrogenase deficiency. ... Alzheimer's disease (AD) with myoclonus: There is an increase in mean volume of large neurons and a decrease in mean volume of ... Maple syrup urine disease (MSUD): An inherited disorder of amino acid metabolism in newborns, MSUD results in neurological ...
He acknowledged the value of synthetic vitamins in treating deficiency diseases, but warned that their use should be temporary ... Elvehjem commented frequently on nutrition as it affects both scientist and layman. "Vitamins should be obtained from natural ... Picking up on the work of Joseph Goldberger, he found that nicotinic acid cured black tongue in dogs, an analogous disease to ... Hart for his studies of the importance of copper in iron-deficiency anemia. A National Research Council fellowship permitted a ...
Phosphoglycerate kinase deficiency affects step 7 of glycolysis. Pyruvate kinase deficiency affects the 10th and last step of ... Glycogen storage diseases that affect the liver typically cause hepatomegaly and hypoglycemia; those that affect skeletal ... Glucose-6-phosphate isomerase deficiency affects step 2 of glycolysis. Triosephosphate isomerase deficiency affects step 5 of ... Glycogen storage diseases are enzyme deficiencies which impair glycogen synthesis, glycogen degradation or glycolysis. The two ...
These include hyperglucagonemia, zinc deficiency, fatty acid deficiency, hypoaminoacidemia, and liver disease. The pathogenesis ... It particularly affects the skin around the mouth and distal extremities; but may also be found on the lower abdomen, buttocks ... Celiac disease Ulcerative colitis Crohn's disease Hepatic cirrhosis Hepatocellular carcinoma Lung cancer, including small cell ... It commonly affects the limbs and skin surrounding the lips, although less commonly the abdomen, perineum, thighs, buttocks, ...
The disease scurvy is caused by vitamin C deficiency and can be prevented and treated with vitamin C containing foods or ... Effect of ascorbate deficiency on the in situ activity of gamma-butyrobetaine hydroxylase" (PDF). The Journal of Biological ... Ashor AW, Lara J, Mathers JC, Siervo M (July 2014). "Effect of vitamin C on endothelial function in health and disease: a ... It is unclear if supplementation affects the risk of cancer, cardiovascular disease, or dementia. It may be taken by mouth or ...
Acid maltase deficiency Danon disease This disorder was described in 1988 by Kalimo et al in Finland in three brothers. The ... As a result males are much more commonly affected than females. It is due to a mutation in VMA21 gene - the human homolog of ... This disease usually presents between the ages of 5 to 10 years old. The usual picture is with weakness involving the upper ... The incidence of this disease is not precisely known but it is considered to be rare (< 1/106 population). It has been reported ...
In effect, the double bond is shifted over. Isomerase plays a role in human disease. Deficiencies of this enzyme can cause ... TPI deficiency is very rare with less than 50 cases reported in literature. Being an autosomal recessive inherited disease, TPI ... The disease referred to as triosephosphate isomerase deficiency (TPI), is a severe autosomal recessive inherited multisystem ... "Triosephosphate Isomerase Deficiency". NORD. Retrieved 14 December 2013. "Triose phosphate isomerase deficiency -TPI" (PDF). ...
... excesses and deficiencies of key minerals). Disease can affect all parts of the plant, causing spotting, rotting, cankers, ... Disease and pest resistance are superior to 'Fuerte'. 'Zutano' Originated by R.L. Ruitt in Fallbrook in 1926, this Mexican ... Choquette' bore large fruit of good eating quality in large quantities and had good disease resistance, and thus became a major ... After the North American Free Trade Agreement (NAFTA) went into effect in 1994, Mexico tried exporting avocados to the US. The ...
"MnSOD deficiency has a differential effect on disease progression in two different ALS mutant mouse models". Muscle & Nerve. 38 ... has no effect on their disease course. G93A (glycine 93 changed to alanine) is a comparatively rare mutation, but has been ... also known as ischemic heart disease). Ischemic heart disease, which results from an occlusion of one of the major coronary ... The disease course of this mutation is extremely long, with the typical time from onset to death being over 15 years. Mouse ...
2006). "Effect of antibacterial honey on the ocular flora in tear deficiency and meibomian gland disease". Cornea. 25 (9): 1012 ... 1953). "Antibacterial effect of elemental sulfur". Journal of Infectious Diseases. 93 (1): 28-35. doi:10.1093/infdis/93.1.28. ... Vasculitis and Diffuse Lung Diseases. 20 (3): 197-203. PMID 14620162. Inoue, Y; Suga, M (2008). "Granulomatous diseases and ... Whether this is a root causality, just opportunistic and a side effect, or a more complex pathological duality between P. acnes ...
Menkes disease, a genetic condition of copper deficiency, was first described by John Menkes in 1962. It is a rare X-linked ... The disease, which affects about 1/30,000 infants of both genders, may become clinically evident at any time from infancy ... Copper deficiency and toxicity can be either of genetic or non-genetic origin. The study of copper's genetic diseases, which ... The disease therefore resembles a severe nutritional copper deficiency despite adequate ingestion of copper. Symptoms of the ...
Effect of iodine deficiency on thyroid hormone synthesis[edit]. This section does not cite any sources. Please help improve ... A deficiency of iodine leads to decreased production of T3 and T4, enlarges the thyroid tissue and will cause the disease known ... Both excess and deficiency of thyroxine can cause disorders. *Hyperthyroidism (an example is Graves Disease) is the clinical ... Thyroid Disease Manager Collection of elaborate medical articles on thyroid disease, including information on thyroid hormones ...
Some AIHA-related diseases are inherited erythrocyte disorders, such as pyruvate kinase deficiency and osmotic fragility. ... It is normally known to affect humans but was recently found in a litter of Somali kittens. Like AIHA, myelodysplasia causes ...
Complex I deficiency is the reason behind over thirty percent of human mitochondrial diseases. For example, complex I ... Together, the two do not affect the AIF attached to the inner mitochondrial membrane, however they influence the stability of ... Mutations of AIF due to deletions have stimulated the creation of the mouse model of complex I deficiency. ... These AIF-deficient mouse models are important for fixing complex I deficiencies. The identification of AIF-interacting ...
McCoy explains that such a meagre diet would have induced deficiency diseases in a human, but that a Vulcan is able to endure ... Upon arriving at Organia, the crew are affected by a powerful mental disturbance centered on the planet. Kirk, Scotty and Spock ...
Defects in the gene encoding it are associated with HDL deficiencies, including Tangier disease, and with systemic non- ... Apo A1 was also isolated as a prostacyclin (PGI2) stabilizing factor, and thus may have an anticlotting effect. ... Protection from Alzheimer's disease by apo A1 may rely on a synergistic interaction with alpha-tocopherol. Amyloid deposited in ... ApoA1 is often used as a biomarker for prediction of cardiovascular diseases. The ratio apoB-100/apoA1 (i.e. LDL & larger ...
Centers for Disease Control and Prevention. "Iron and Iron Deficiency". Retrieved 12 August 2014. Greenwood, Norman N.; ... This effect also plays a minor role in the toxicity of cyanide, but there the major effect is by far its interference with the ... Centers for Disease Control and Prevention (2002). "Iron deficiency - United States, 1999-2000". MMWR. 51 (40): 897-9. PMID ... Hider, Robert C.; Kong, Xiaole (2013). "Chapter 8. Iron: Effect of Overload and Deficiency". In Astrid Sigel, Helmut Sigel and ...
... cardiovascular disease, and other devastating consequences. LAL Deficiency affects patients of all ages with sudden and ... LAL Deficiency is a serious, life-threatening disease associated with early mortality and significant morbidity. LAL Deficiency ... to address a rare and devastating disease known as lysosomal acid lipase deficiency (LAL Deficiency). Kanuma is a recombinant ... The company was able to produce enzymes targeting Hunter syndrome, Fabry disease and Pompe disease with expression levels and ...
These cells can also be used to treat diseases that affect the central nervous system as well as other neurological disorders. ... epithelial cells have been used in the past to treat genetic liver diseases such as ornithine transcarbamylase deficiency, ... Parkinson's disease is treated with dopamine replacement therapy but is not functional with the late progression of the disease ... These cells are being looked at by scientists as a new and more effiecient way to treat diseases of the liver particularly ...
They list Lyngstadaas syndrome as a "rare disease". Rare disease "Steroid dehydrogenase deficiency dental anomalies , Disease ... "rare disease". This means that Lyngstadaas syndrome, or a subtype of Lyngstadaas syndrome, affects less than 200,000 people in ... The disease is named after the Norwegian professor Ståle Petter Lyngstadaas. Office of Rare Diseases listed Lyngstadaas ... is a rare autosomal recessive liver disease involving an enzyme (steroid dehydrogenase) deficiency and dental anomalies. ...
... a disease which leads to general motor function deficiency and weakness. Further symptoms include fatal apnea. Out of ten ... Prior to death, affected flies show a change in behavior, including uncontrolled movements and a change in electroretinogram ... The Alzheimer's disease (AD) involves difficulty in memory and cognition. The concentrations of acetylcholine and ChAT are ... Nachmansohn D, Berman M (1946). "Studies on choline acetylase; on the preparation of the coenzyme and its effect on the enzyme ...
... famine-induced diseases and diseases of nutritional deficiency. Of the nutritional deficiency diseases, the most commonly ... The diseases that badly affected the population fell into two categories: ... However, the greatest mortality was not from nutritional deficiency diseases, but from famine-induced ailments. The ... They recorded 21,770 total deaths from starvation in the previous decade, and 400,720 deaths from disease. Listed diseases were ...
"Effect of physical inactivity on major non-communicable diseases worldwide: an analysis of burden of disease and life ... "Maternal micronutrient deficiency, fetal development, and the risk of chronic disease". The Journal of Nutrition. 140 (3): 437 ... Diseases of the endocrine system (ICD-10 Chapter IV: Endocrine, nutritional and metabolic diseases - Endocrine diseases, E00- ... Diabetes was one of the first diseases described.[21] The importance of insulin in the disease was determined in the 1920s.[22] ...
... in which several parts of the immune system are affected. This inherited disorder is characterized by increased susceptibility ... Genetic Cause Of Primary Immune Deficiency Disease Identified. Posted by admin on September 25, 2009 Leave a comment (0) Go to ... Combined immunodeficiency is a type of primary immune deficiency disease (PIDD) ... The team that made the discovery was led by Helen Su, M.D., Ph.D., at the National Institute of Allergy and Infectious Diseases ...
Dietary magnesium and copper affect survival time and neuroinflammation in chronic wasting disease. Prion. 2016 May 3;10(3):228 ... Magnesium deficiency and osteoarthritis. Marion Hauser, MS, RD. Some consider magnesium a miracle mineral. Its biological ... and a weakened effect of analgesics (magnesium makes painkillers work better, a subject that you need to discuss with your ... Magnesium deficiency is active in several pathways that have been implicated in osteoarthritis, including: *increased ...
Learn about the very strong link between depression and magnesium deficiency, as well as how to keep your magnesium levels up ... Chronic inflammation, often caused by magnesium deficiency, is at the root of many deadly diseases, including heart disease, ... Lifestyle also affects magnesium levels. For instance, when you use prescription drugs or over-the-counter medications, or you ... These products are not intended to diagnose, treat, cure or prevent any disease. Information on this site is provided for ...
Learn why magnesium deficiency may be responsible for more diseases than the lack of any other nutrient. Magnesium Deficiency ... and magnesium deficiency may be responsible for more diseases than the lack of any other nutrient, because it can affect ... Comments for Magnesium Deficiency Signs And Symptoms. Leave a comment. Name. Email. Your comment (No HTML). Type the text from ... Magnesium deficiency does not show up in blood tests. In fact, most doctors and laboratories dont include magnesium status in ...
Abca1 Deficiency Affects Alzheimers Disease-Like Phenotype in Human ApoE4 But Not in ApoE3-Targeted Replacement Mice. Nicholas ... Abca1 Deficiency Affects Alzheimers Disease-Like Phenotype in Human ApoE4 But Not in ApoE3-Targeted Replacement Mice ... Abca1 Deficiency Affects Alzheimers Disease-Like Phenotype in Human ApoE4 But Not in ApoE3-Targeted Replacement Mice ... Abca1 Deficiency Affects Alzheimers Disease-Like Phenotype in Human ApoE4 But Not in ApoE3-Targeted Replacement Mice ...
Adiponectin deficiency modulates adhesion molecules expression and cytokine production but does not affect disease severity in ... We investigated the effect of adiponectin (APN) deficiency in the CD4+CD45RBhigh transfer model of colitis. Recombination ... The present study demonstrates that APN deficiency does not alter disease severity in the transfer model of chronic colitis in ... Pini M, Gove ME, Fayad R, Cabay RJ, Fantuzzi G. Adiponectin deficiency does not affect development and progression of ...
... and clinical studies that provide insights into the endocrine system and its associated diseases at a genomic, molecular, ... 4. Vitamin D Deficiency, Bone Disorders, and Cardiovascular Diseases. The consequences of vitamin D deficiency on the human ... R. Scragg, A. W. Stewart, D. Waayer et al., "Effect of monthly high-dose vitamin D supplementation on cardiovascular disease in ... Rickets is the principal vitamin D-deficiency disease in infants. In the majority of studies in which circulating 25OHD has ...
Vitamin A Deficiency Can Affect The Eye. This is because vitamin A to maintain healthy cells in the eye and the various ... Vitamin A Deficiency Can Affect The Eye. To maintain good eye health, Vitamin A is essential nutrients. Found that vitamin A ... Reduce vitamin A deficiency. To successfully reduce vitamin A deficiency, adequacy of intake of vitamin A should be ascertained ... When vitamin A is not available to the body, gradual change began to affect the eye. ...
Infographic: Circadian Clock Affects Health and Disease. By Jyoti Madhusoodanan , April 1, 2017 ... Across many diseases, taking medication at specific times of day may make the therapy more effective. ... The bodys rhythms could affect numerous ailments as well as how people respond to treatments. ... tags: lipoprotein lipase deficiency x disease/medicine x The Scientist. » lipoprotein lipase deficiency and disease/medicine ...
A Genetic Disease With a Domino Effect: Multiple Sulfatase Deficiency , PLOS Blogs Network says: ... A Genetic Disease With a Domino Effect: Multiple Sulfatase Deficiency. September 7, 2017. Ricki Lewis, PhD Uncategorized ... Orphanet Journal of Rare Diseases). As a result of the falling domino-like effect of SUMF1 mutations, the urine of kids with ... Multiple sulfatase deficiency is a big Sprint store on fire.. Sites of mutations in the enzyme that is abnormal in multiple ...
A new study has shown that Vitamin D deficiency in victims of Inflammatory Bowel Disease (IBD)elevates their risk of ... Vitamin D Deficiency Causes Various Diseases. Vitamin D interacts with our DNA at several points and directly influences two ... Food Combinations that Affect Your Well Being. Combining the foods to give you the optimum nutritional value is the key to ... According the study, Crohns disease patients with Vitamin D deficiency were four times more likely to have a higher rate of ...
This topic contains 14 study abstracts on Androgen Deficiency indicating that the following substances may be helpful: ... Propyl paraben has an adverse effect on the male reproductive system. Dec 01, 2002 Add to My Research ... Diseases : Androgen Deficiency, Estrogen Deficiency, Hormone Insufficency, Low DHEA, Progesterone: Low, Testosterone: Too Low ... Diseases : Androgen Deficiency, Congestive Heart Failure, Heart Failure. Pharmacological Actions : β(2)-adrenoceptor up- ...
Metabolic Diseases. Slow Virus Diseases. Avitaminosis. Deficiency Diseases. Malnutrition. Nutrition Disorders. Vitamins. ... Virus Diseases. Sexually Transmitted Diseases, Viral. Sexually Transmitted Diseases. Immune System Diseases. Hyperinsulinism. ... Condition or disease Intervention/treatment Phase Human Immunodeficiency Virus (HIV) Vitamin D Deficiency HIV Infections Drug: ... Study of Vitamin D and Effect on Heart Disease and Insulin Resistance. The safety and scientific validity of this study is the ...
Vitamin D Deficiency. Vitamins. Vitamin D. Eclampsia. Pre-Eclampsia. Avitaminosis. Deficiency Diseases. Malnutrition. Nutrition ... Condition or disease Intervention/treatment Phase Vitamin D Deficiency Pre-Eclampsia Drug: 400 IU Vitamin D3 Drug: 4000 IU ... Effect of Vitamin D3 Supplementation in Pregnancy on Risk of Pre-eclampsia. The safety and scientific validity of this study is ... Vitamin D3 has key role in decidualization and implantation of placenta.Vitamin D deficiency is thought to have positive ...
The effect of mGlu8 deficiency in animal models of psychiatric diseases. Research output: Contribution to journal › Journal ... Animals, Anxiety Disorders, Chlordiazepoxide, Conditioning (Psychology), Conditioning, Operant, Disease Models, Animal, ... deficiency. We found no changes in sensory processing, locomotor activity, prepulse inhibition, phencyclidine-induced changes ...
... and immunoglobulin deficiencies also conducted a literature search on the main medical databases, which revealed that SNCD ... A research team that conducted an analysis of the relationship between seronegative celiac disease (SNCD) ... The team diagnosed seronegative celiac disease in a patient affected by sIgMD using the tTG-mRNA assay. One-year on a gluten- ... underlies the association of seronegative celiac disease with immunoglobulin deficiencies. Therefore, celiac disease may be ...
Here is a list of diseases related to a deficiency in human growth hormone levels. ... Get the facts about low levels of HGH and disease that could occur if left untreated. ... When we examine the effect of low levels of HGH, diseases such as dementia, cardiovascular problems, type 2 diabetes, and ... Diabetes, Atherosclerosis, Cardiovascular Disease, and Growth Hormone Deficiency. Growth hormone deficiency has a clinically ...
Intrauterine growth retardation predisposes toward long-term morbidity from type 2 diabetes and cardiovascular disease. To ... Disease: pyruvate kinase deficiency. Hum Genet 2009; 125: 343.. PubMed PubMed Central Google Scholar ... A protective effect of breastfeeding on the progression of non-alcoholic fatty liver disease. Arch Dis Child 2009; 94: 801-805. ... cellular processes and subsequent susceptibility to disease. Any cellular component may be affected by programming: membrane ...
Scurvy: How Can Science Help Prevent Dietary Deficiency Diseases?. 1347 Words , 6 Pages Scurvy: How Can Science Help Prevent ... How Culture Affects Nursing Care And The Way Humans Care For Themselves. 946 Words , 4 Pages and practice care in different ... Dietary Deficiency Diseases? Figure [ 1 ] Courtesy of Google Images An Introduction Scurvy is a disease which is caused by a ... Scurvy: How Can Science Help Prevent Dietary Deficiency Diseases?. 1347 Words , 6 Pages ...
MDR3 deficiency is a rare genetic disorder that predominantly affects the liver. The disorder represents a spectrum of diseases ... Affected Populations. MDR3 deficiency affects males and females in equal numbers. The exact incidence and prevalence of MDR3 ... In MDR3 deficiency cholestasis, this interruption or suppression usually begins during the first few months of life. Affected ... Various metabolic diseases are associated with liver dysfunction similar to that found in MDR3 deficiency. These disorders ...
There are no standardized treatment protocols or guidelines for affected individuals. Due to the rarity of the disease, there ... Rare Disease Database. 0-9• A• B• C• D• E• F• G• H• I• J• K• L• M• N• O• P• Q• R• S• T• U• V• W• X• Y• Z ... NGLY1 deficiency is a rare disorder that can affect multiple systems of the body. Affected individuals may have delays in ... A deficiency or lack of one of these enzymes can lead to a variety of symptoms potentially affecting multiple organ systems. ...
Interleukin-12/23 deficiency differentially affects pathology in male and female Alzheimers disease-like mice ... Interleukin-12/23 deficiency differentially affects pathology in male and female Alzheimers disease-like mice. ... IL12p40 deficiency gender specifically reduces A plaque burden in male APP23 mice, while in female mice, a significant ... We tested the gender-specific effect of lack of IL12p40, the shared subunit of interleukin (IL)-12 and IL-23, that we ...
Does Marijuana affect LDL cholesterol levels? over a year ago. Testosterone Part XI - Testosterone Deficiency and Heart ... Heart Diseases Part X - How to Prevent Heart Disease With Diet over a year ago. ... Coronary Artery Disease Alternative Treatment: 6 Natural Therapies for Atherosclerosis Are Your Cholesterol Numbers Normal? ... How To Lower Your Cholesterol And Prevent Heart Disease Without Drugs High Cholesterol And Omega-3 Fats: How Can Fish Oil Help ...
Oxford researchers have shown how vitamin D interacts with our DNA and how a deficiency in it brings on a slew of serious ... This affects other proteins that are made.. The receptor can bind to nearly three thousand sites on the genome, in regions that ... Vitamin D deficiency linked to autoimmune diseases and cancer. Oxford researchers have shown how vitamin D interacts with our ... We know that vitamin D deficiency can lead to rickets. But a lack of vitamin D can also bring on less obvious ones to the naked ...
This topic contains 7 study abstracts on Zinc Deficiency indicating that the following substances may be helpful: Zinc, and Red ... Effect of B-vitamin deficiency on biochemical, immunologic markers and trace element status of rats and miceDec 31, 2017. ... Diseases : Anemia: Iron Deficiency, Iron Deficiency/Malabsorption, Vitamin A Deficiency, Zinc Deficiency ... Diseases : Magnesium Deficiency, Mineral Deficiencies: Selenium, Prediabetes, Zinc Deficiency. Additional Keywords : Risk ...
  • Its biological functions are far too numerous to provide here other than its protective functions in cardiovascular disease, certain cancers, cholesterol metabolism, problems of fatigue, problems of sleep, and problems of depression and anxiety. (caringmedical.com)
  • When you're lacking magnesium, the result can be systemic inflammation, which has a noticeable negative effect on your brain and your behavior. (bodymanual.com)
  • In the late 1970s, medical records suggested that a small but growing outbreak of immune deficiency-related diseases had occurred almost simultaneously in North America, Haiti, Western Europe and Central and East Africa. (thebody.com)
  • Further research suggested that some factors that these people acquired (rather than a factor with which they were born or inherited) -- such as an infection with a novel germ -- made them susceptible to immune deficiency. (thebody.com)
  • The KS that occurred in these and in future cases of acquired immune deficiency was not restricted to the feet or legs but could strike anywhere on the body. (thebody.com)
  • By the early 1980s, these cases of immune deficiency-related diseases were called AIDS. (thebody.com)
  • The Immune Deficiency and Histiocytosis Program within the Division of Bone Marrow Transplantation and Immune Deficiency offers a unique combination of expert medical care, state-of-the-art testing capabilities and extensive research for children with immune deficiencies. (cincinnatichildrens.org)
  • By reviewing the information unique to each patient, our team is able to schedule appointments with other relevant subspecialists in conjunction with the first evaluation in the Immune Deficiency Clinic. (cincinnatichildrens.org)
  • Patients also benefit from the coordinated expertise of other pediatric subspecialists within Cincinnati Children's who work closely with the immune deficiency physician. (cincinnatichildrens.org)
  • The most common, and therefore the most medically significant, antibody deficiency disease is common variable immune deficiency. (transparencymarketresearch.com)
  • AIDS is a specific disease, and it stands for acquired immune deficiency syndrome. (telegram.com)
  • Thymic changes also occur in acute infectious diseases, including a severe thymic atrophy, mainly due to the depletion of CD4+CD8+ thymocytes, decrease in thymocyte proliferation, in parallel to densification of the epithelial network and increase in the extracellular matrix contents, with consequent disturbances in thymocyte migration and export. (nih.gov)
  • Thus, strategies inducing thymus replenishment should be considered as adjuvant therapeutics to improve immunity in malnutrition and/or acute infectious diseases. (nih.gov)
  • Emerging Infectious Diseases , 18 (11), 1717-1722. (cdc.gov)
  • Emerging Infectious Diseases , 18 (11), 1723-1728. (cdc.gov)
  • Here we investigate the effect of temporal changes in serum 25-hydroxyvitamin D (25(OH)D) concentrations on metabolic syndrome among Canadians enrolled in a preventive health program that promotes vitamin D supplementation. (mdpi.com)
  • A research conducted at Loyola University Health System (LUHS) has revealed that vitamin D deficiency is associated with a significant increase in lung transplant rejection. (medindia.net)
  • We used APP/E3 and APP/E4 mice generated by crossing APP/PS1ΔE9 transgenic mice to human APOE3- and APOE4-targeted replacement mice and examined Abca1 gene dose effect on amyloid deposition and cognition. (jneurosci.org)
  • Willow has a gap in both copies of a gene, SUMF1 , that normally encodes a protein called sulfatase modifying factor 1, making her one of about 50 people in the world with multiple sulfatase deficiency (MSD). (plos.org)
  • NGLY1 deficiency is caused by a disease causing (pathogenic) variant (mutation) in the NGLY1 gene. (rarediseases.org)
  • Scientists who last year identified a new genetic risk factor for coeliac disease, have, following continued research, discovered an additional seven gene regions implicated in causing the condition. (glutenfreeworks.com)
  • Barth syndrome is a rare metabolic disease in boys caused by mutation of a gene called tafazzin or TAZ. (news-medical.net)
  • Women who carry one copy of the gene can pass G6PD deficiency to their children. (hopkinsmedicine.org)
  • Men who get the gene have G6PD deficiency. (hopkinsmedicine.org)
  • In contrast to individuals with classic Tarui disease, who express only the L4 type isozyme in red blood cells, individuals with late-onset Tarui disease showed the presence of a few hybrid isozymes of M+L with the predominant L4 species, suggesting a "leaky" mutation of the gene coding the M subunit. (medscape.com)
  • A study shows that, in a mouse model of neuronopathic Gaucher disease, delivery of a gene therapy into the brains of fetal animals prevents neurodegeneration, ameliorates associated neuroinflammation and promotes survival. (nature.com)
  • Factor XI deficiency is caused by a genetic defect, or mutation, in the F11 gene that codes for the factor XI protein. (health24.com)
  • The disease develops around age 50 on average but does not run in families, which makes it unlikely that a single gene is responsible, Browne said. (telegram.com)
  • Protein deficiency is common among people who live in developing countries, those who live in impoverished communities in developed countries and in the elderly who lack access to nutritious food. (livestrong.com)
  • Cachexia is a condition that involves protein deficiency, depletion of skeletal muscle and an increased rate of protein degradation, according to research by D.P. Kotler published in the 'Annals of Internal Medicine' in 2000. (livestrong.com)
  • Some racial and ethnic populations are affected more than others. (encyclopedia.com)
  • These residents' physical and mental health conditions, facilities' abilities to deal with infectious disease, and occupancy rates are all important considerations when thinking about addressing the spread of COVID-19 in nursing homes and other vulnerable populations. (kff.org)
  • Although data could not be found to prove the hypothesis, there were indications of a rise in palm oil price during this period which could explain the distribution of disease among the populations who were poorest and furthest from the supply route. (ennonline.net)
  • The APOE ε 4 allele is the major genetic risk factor of sporadic Alzheimer's disease (AD). (jneurosci.org)
  • Alzheimer's disease (AD) is a late-onset dementia characterized by the presence of senile plaques made of amyloid-β (Aβ), neurofibrillary tangles, and cognitive decline. (jneurosci.org)
  • Memory decline associated with AGHD can lead to increased risks for dementia, Alzheimer's disease, and other neurodegenerative conditions. (zarias.com)
  • Pathological aggregation of amyloid-β (Aβ) is a main hallmark of Alzheimer's disease (AD). (mdc-berlin.de)
  • An enzyme involved in the formation of the amyloid-beta protein associated with Alzheimer's disease can also alter the mechanism by which signals are transmitted between brain cells, the disruption of which can cause seizures. (medindia.net)
  • Alzheimer's disease is characterized by plaques within the brain of the toxic amyloid-beta protein. (medindia.net)
  • While previous studies have already revealed that stress boosts the production of a brain peptide critical to Alzheimer's disease, a new study. (medindia.net)
  • It continues to research on many degenerative challenging diseases such as cancer, stem cell, diabetes, Alzheimer's disease and more. (prweb.com)
  • Journal of Alzheimer's Disease. (lancs.ac.uk)
  • Adult growth hormone deficiency (AGHD) can lead to many potentially dangerous health concerns if left untreated. (zarias.com)
  • Accidental consumption or overdoses of the anticoagulant drug warfarin can lead to a deficiency of the vitamin K-dependent blood-clotting proteins and a serious bleeding tendency. (britannica.com)
  • Not eating enough folate can lead to a deficiency in just a few weeks. (healthline.com)
  • Pathology) acquired immune (or immuno-)deficiency syndrome: a condition, caused by a virus, in which certain white blood cells (lymphocytes) are destroyed, resulting in loss of the body's ability to protect itself against disease. (thefreedictionary.com)
  • The new mitochondrial DNA (mtDNA) variant drastically speeds up the disease progression in a mouse model of GRACILE syndrome. (news-medical.net)
  • People with dopamine transporter deficiency syndrome may have a shortened lifespan, although the long-term effects of this condition are not fully understood. (medlineplus.gov)
  • These estimates were independent of the effect of baseline serum 25(OH)D concentrations on metabolic syndrome. (mdpi.com)
  • In late-onset Tarui disease, the myopathic syndrome results from a mutation of the M subunit distinct from those that cause classic Tarui disease. (medscape.com)
  • In animal models, intrauterine exposure to maternal undernourishment affects the expression of multiple genes involved in different metabolic pathways. (nature.com)
  • Scientists have mapped parts of the genome that are influenced by vitamin D. With some 200 genes found to interact with vitamin D, a deficiency in the vitamin can have serious consequences. (zdnet.com)
  • Their results identified seven new risk regions, six of which harbour important genes critical in the control of immune responses, highlighting their significance in the development of the disease. (glutenfreeworks.com)
  • Pathogenic variants in other genes including PDHB , DLAT , PDHX , DLD , and PDP1 can also cause PDC deficiency. (nih.gov)
  • Therefore reliable information of dogs that do not carry disease genes is the key to controlling this disease. (laboklin.co.uk)
  • Of an estimated 6,500 to 7,000 known rare diseases, only a fraction - maybe 5% - have U.S. Food and Drug Administration-approved treatments. (news-medical.net)
  • Synageva BioPharma Corp. (Synageva) (NASDAQ:GEVA), a biopharmaceutical company developing therapeutic products for rare diseases, today announced the publication of an overview of lysosomal acid lipase deficiency (LAL Deficiency) in the online version and an upcoming print edition of Atherosclerosis , the official journal of the European Atherosclerosis Society. (thestreet.com)
  • Synageva's additional pipeline programs include other proteins targeting rare diseases at various stages of preclinical development. (thestreet.com)
  • PIDD is a group of rare diseases that are genetic in nature. (transparencymarketresearch.com)
  • Pyruvate dehydrogenase complex (PDC) deficiency is a type of metabolic disease . (nih.gov)
  • The different functions of white, brown and beige fat might yield new targets in the fight against obesity and metabolic disease. (nature.com)
  • We tested the gender-specific effect of lack of IL12p40, the shared subunit of interleukin (IL)-12 and IL-23, that we previously reported to ameliorate pathology in APPPS1 mice. (mdc-berlin.de)