Amiodarone: An antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibiting POTASSIUM CHANNELS and VOLTAGE-GATED SODIUM CHANNELS. There is a resulting decrease in heart rate and in vascular resistance.Heart Failure: A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.Heart: The hollow, muscular organ that maintains the circulation of the blood.Bibliometrics: The use of statistical methods in the analysis of a body of literature to reveal the historical development of subject fields and patterns of authorship, publication, and use. Formerly called statistical bibliography. (from The ALA Glossary of Library and Information Science, 1983)Journal Impact Factor: A quantitative measure of the frequency on average with which articles in a journal have been cited in a given period of time.Anti-Arrhythmia Agents: Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.Heart Rate: The number of times the HEART VENTRICLES contract per unit of time, usually per minute.Publications: Copies of a work or document distributed to the public by sale, rental, lease, or lending. (From ALA Glossary of Library and Information Science, 1983, p181)Publishing: "The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.Cardiac Output, Low: A state of subnormal or depressed cardiac output at rest or during stress. It is a characteristic of CARDIOVASCULAR DISEASES, including congenital, valvular, rheumatic, hypertensive, coronary, and cardiomyopathic. The serious form of low cardiac output is characterized by marked reduction in STROKE VOLUME, and systemic vasoconstriction resulting in cold, pale, and sometimes cyanotic extremities.Heart Failure, Systolic: Heart failure caused by abnormal myocardial contraction during SYSTOLE leading to defective cardiac emptying.Databases, Bibliographic: Extensive collections, reputedly complete, of references and citations to books, articles, publications, etc., generally on a single subject or specialized subject area. Databases can operate through automated files, libraries, or computer disks. The concept should be differentiated from DATABASES, FACTUAL which is used for collections of data and facts apart from bibliographic references to them.MEDLINE: The premier bibliographic database of the NATIONAL LIBRARY OF MEDICINE. MEDLINE® (MEDLARS Online) is the primary subset of PUBMED and can be searched on NLM's Web site in PubMed or the NLM Gateway. MEDLINE references are indexed with MEDICAL SUBJECT HEADINGS (MeSH).Authorship: The profession of writing. Also the identity of the writer as the creator of a literary production.Heart Failure, Diastolic: Heart failure caused by abnormal myocardial relaxation during DIASTOLE leading to defective cardiac filling.Benzofurans: Compounds that contain a BENZENE ring fused to a furan ring.Stroke Volume: The amount of BLOOD pumped out of the HEART per beat, not to be confused with cardiac output (volume/time). It is calculated as the difference between the end-diastolic volume and the end-systolic volume.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Abstracting and Indexing as Topic: Activities performed to identify concepts and aspects of published information and research reports.Myocardium: The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.Heart Diseases: Pathological conditions involving the HEART including its structural and functional abnormalities.PubMed: A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.Medical Subject Headings: Controlled vocabulary thesaurus produced by the NATIONAL LIBRARY OF MEDICINE. It consists of sets of terms naming descriptors in a hierarchical structure that permits searching at various levels of specificity.Cardiomyopathy, Dilated: A form of CARDIAC MUSCLE disease that is characterized by ventricular dilation, VENTRICULAR DYSFUNCTION, and HEART FAILURE. Risk factors include SMOKING; ALCOHOL DRINKING; HYPERTENSION; INFECTION; PREGNANCY; and mutations in the LMNA gene encoding LAMIN TYPE A, a NUCLEAR LAMINA protein.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Heart Transplantation: The transference of a heart from one human or animal to another.Adrenergic beta-Antagonists: Drugs that bind to but do not activate beta-adrenergic receptors thereby blocking the actions of beta-adrenergic agonists. Adrenergic beta-antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches, and anxiety.Ventricular Function, Left: The hemodynamic and electrophysiological action of the left HEART VENTRICLE. Its measurement is an important aspect of the clinical evaluation of patients with heart disease to determine the effects of the disease on cardiac performance.Hemodynamics: The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM.Chronic Disease: Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care. (Dictionary of Health Services Management, 2d ed)Atrial Fibrillation: Abnormal cardiac rhythm that is characterized by rapid, uncoordinated firing of electrical impulses in the upper chambers of the heart (HEART ATRIA). In such case, blood cannot be effectively pumped into the lower chambers of the heart (HEART VENTRICLES). It is caused by abnormal impulse generation.Ventricular Dysfunction, Left: A condition in which the LEFT VENTRICLE of the heart was functionally impaired. This condition usually leads to HEART FAILURE; MYOCARDIAL INFARCTION; and other cardiovascular complications. Diagnosis is made by measuring the diminished ejection fraction and a depressed level of motility of the left ventricular wall.Treatment Failure: A measure of the quality of health care by assessment of unsuccessful results of management and procedures used in combating disease, in individual cases or series.Natriuretic Peptide, Brain: A PEPTIDE that is secreted by the BRAIN and the HEART ATRIA, stored mainly in cardiac ventricular MYOCARDIUM. It can cause NATRIURESIS; DIURESIS; VASODILATION; and inhibits secretion of RENIN and ALDOSTERONE. It improves heart function. It contains 32 AMINO ACIDS.Bibliography as Topic: Discussion of lists of works, documents or other publications, usually with some relationship between them, e.g., by a given author, on a given subject, or published in a given place, and differing from a catalog in that its contents are restricted to holdings of a single collection, library, or group of libraries. (from The ALA Glossary of Library and Information Science, 1983)Cardiac Pacing, Artificial: Regulation of the rate of contraction of the heart muscles by an artificial pacemaker.Prospective Studies: Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.Ventricular Remodeling: The geometric and structural changes that the HEART VENTRICLES undergo, usually following MYOCARDIAL INFARCTION. It comprises expansion of the infarct and dilatation of the healthy ventricle segments. While most prevalent in the left ventricle, it can also occur in the right ventricle.Follow-Up Studies: Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.Peer Review, Research: The evaluation by experts of the quality and pertinence of research or research proposals of other experts in the same field. Peer review is used by editors in deciding which submissions warrant publication, by granting agencies to determine which proposals should be funded, and by academic institutions in tenure decisions.Tachycardia: Abnormally rapid heartbeat, usually with a HEART RATE above 100 beats per minute for adults. Tachycardia accompanied by disturbance in the cardiac depolarization (cardiac arrhythmia) is called tachyarrhythmia.Echocardiography: Ultrasonic recording of the size, motion, and composition of the heart and surrounding tissues. The standard approach is transthoracic.Heart Atria: The chambers of the heart, to which the BLOOD returns from the circulation.Cardiotonic Agents: Agents that have a strengthening effect on the heart or that can increase cardiac output. They may be CARDIAC GLYCOSIDES; SYMPATHOMIMETICS; or other drugs. They are used after MYOCARDIAL INFARCT; CARDIAC SURGICAL PROCEDURES; in SHOCK; or in congestive heart failure (HEART FAILURE).Heart Defects, Congenital: Developmental abnormalities involving structures of the heart. These defects are present at birth but may be discovered later in life.Arrhythmias, Cardiac: Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by the abnormalities in HEART RATE, disorders of electrical impulse generation, or impulse conduction.Heart Function Tests: Examinations used to diagnose and treat heart conditions.Risk Factors: An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.Biomedical Research: Research that involves the application of the natural sciences, especially biology and physiology, to medicine.Myocardial Contraction: Contractile activity of the MYOCARDIUM.Journalism, Medical: The collection, writing, and editing of current interest material on topics related to biomedicine for presentation through the mass media, including newspapers, magazines, radio, or television, usually for a public audience such as health care consumers.Myocardial Infarction: NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).Electrocardiography: Recording of the moment-to-moment electromotive forces of the HEART as projected onto various sites on the body's surface, delineated as a scalar function of time. The recording is monitored by a tracing on slow moving chart paper or by observing it on a cardioscope, which is a CATHODE RAY TUBE DISPLAY.Prognosis: A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.Information Storage and Retrieval: Organized activities related to the storage, location, search, and retrieval of information.Digoxin: A cardiotonic glycoside obtained mainly from Digitalis lanata; it consists of three sugars and the aglycone DIGOXIGENIN. Digoxin has positive inotropic and negative chronotropic activity. It is used to control ventricular rate in ATRIAL FIBRILLATION and in the management of congestive heart failure with atrial fibrillation. Its use in congestive heart failure and sinus rhythm is less certain. The margin between toxic and therapeutic doses is small. (From Martindale, The Extra Pharmacopoeia, 30th ed, p666)Randomized Controlled Trials as Topic: Works about clinical trials that involve at least one test treatment and one control treatment, concurrent enrollment and follow-up of the test- and control-treated groups, and in which the treatments to be administered are selected by a random process, such as the use of a random-numbers table.Dogs: The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)Propanolamines: AMINO ALCOHOLS containing the propanolamine (NH2CH2CHOHCH2) group and its derivatives.Government Publications as Topic: Discussion of documents issued by local, regional, or national governments or by their agencies or subdivisions.Double-Blind Method: A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.Tachycardia, Ventricular: An abnormally rapid ventricular rhythm usually in excess of 150 beats per minute. It is generated within the ventricle below the BUNDLE OF HIS, either as autonomic impulse formation or reentrant impulse conduction. Depending on the etiology, onset of ventricular tachycardia can be paroxysmal (sudden) or nonparoxysmal, its wide QRS complexes can be uniform or polymorphic, and the ventricular beating may be independent of the atrial beating (AV dissociation).Retrospective Studies: Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.Editorial Policies: The guidelines and policy statements set forth by the editor(s) or editorial board of a publication.Science: The study of natural phenomena by observation, measurement, and experimentation.Myocytes, Cardiac: Striated muscle cells found in the heart. They are derived from cardiac myoblasts (MYOBLASTS, CARDIAC).Cardiomyopathies: A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classified according to their predominant pathophysiological features (DILATED CARDIOMYOPATHY; HYPERTROPHIC CARDIOMYOPATHY; RESTRICTIVE CARDIOMYOPATHY) or their etiological/pathological factors (CARDIOMYOPATHY, ALCOHOLIC; ENDOCARDIAL FIBROELASTOSIS).
If this does not occur, however, possible adverse outcomes include palpitations, dizziness, lightheadedness (during shorter ... medical citation needed] Hypokalemia (low blood potassium) Hypomagnesemia (low blood magnesium) Hypocalcemia (low blood calcium ... Heart failure Left ventricular hypertrophy Hypothermia Subarachnoid hemorrhage Hypothyroidism The ECG tracing in torsades ... related to a potential risk of abnormal heart rhythms with high doses" (Press release). USFDA. February 15, 2013. Retrieved ...
... citation needed] Death usually occurs within two to six hours in fatal poisoning (20 to 40 mL of tincture may prove fatal). The ... Tingling will start at the point of absorption and extend up the arm to the shoulder, after which the heart will start to be ... Marked symptoms may appear almost immediately, usually not later than one hour, and "with large doses death is almost ... Other drugs used for ventricular arrhythmia include lidocaine, amiodarone, bretylium, flecainide, procainamide, and mexiletine ...
... citation needed]. The inhibition of the sodium pump may also improve baroreceptor sensitivity in heart failure and may explain ... usually in 125-μg or 250-μg doses.[citation needed] ... The occurrence of adverse drug reactions is common, owing to ... Examples commonly used in patients with heart problems include spironolactone, verapamil and amiodarone. In patients with ... In overdose, the usual supportive measures are needed. If arrhythmias prove troublesome, or malignant hyperkalaemia occurs ( ...
... citation needed] In dogs treated for hypothyroidism (lack of thyroid hormone), hyperthyroidism may occur as a result of an ... Use of higher doses of radioiodine reduces the incidence of treatment failure, with penalty for higher response to treatment ... "Leventa-Precautions/Adverse Reactions". Intervet. Archived from the original on 14 January 2012. Retrieved 27 July 2011. ... Thyroid storm is a severe form of thyrotoxicosis characterized by rapid and often irregular heart beat, high temperature, ...
Adverse effectsEdit. This article needs more medical references for verification or relies too heavily on primary sources. ... This enzyme induction occurs at therapeutic doses. In fact, people taking these drugs have displayed the highest degree of ... 1999 reported that one of their treatment failures, a 45-year-old woman taking 50 mg a day along with lithium 600 mg/day, ... primidone and other anticonvulsant drugs increase the amount of fentanyl needed during craniotomy based on the patient's heart ...
... citation needed] Dual reuptake inhibitors have low affinity at neuronal receptors of the other neurotransmitters, which have ... At low doses (,150 mg/day), it acts only on serotonergic transmission. At moderate doses (,150 mg/day), it acts on serotonergic ... Symptoms may occur because concentrations of neurotransmitters, such as norepinephrine and serotonin, are insufficient, leading ... Duloxetine has also been associated with cases of hepatic failure and should not be prescribed to patients with chronic alcohol ...
This section needs additional citations for verification. Please help improve this article by adding citations to reliable ... There is some evidence to suggest that high-dose statin provides greater benefit compared with regular-dose and low-dose statin ... Primary prevention of heart attack, stroke, and need for revascularization procedures in people who have risk factors such as ... Adverse effectsEdit. MajorEdit. *Type 2 diabetes mellitus, an uncommon class effect of all statins.[36][37][38] ...
This section needs additional citations for verification. Please help improve this article by adding citations to reliable ... However, there is an increased risk of statin-associated adverse effects with such high-dose statin treatment.[26] There is a ... Primary prevention of heart attack, stroke, and need for revascularization procedures in patients who have risk factors such as ... Very rarely, atorvastatin may cause rhabdomyolysis,[31] and it may be very serious leading to acute renal failure due to ...
... citation needed]. Neither of these ocular signs should be confused with exophthalmos (protrusion of the eyeball), which occurs ... Use of higher doses of radioiodine reduces the incidence of treatment failure, with penalty for higher response to treatment ... "Leventa-Precautions/Adverse Reactions". Intervet. Archived from the original on 14 January 2012. Retrieved 27 July 2011.. ... Heart murmurs and a gallop rhythm can develop due to secondary hypertrophic cardiomyopathy. About 70% of afflicted cats also ...
... citation needed]. Catheter shearing is a very infrequent complication, but a very real danger. Shearing occurs when part of the ... Possible consequences include hypertension, heart failure, and pulmonary edema.. Hypothermia[edit]. The human body is at risk ... Infiltration is one of the most common adverse effects of IV therapy[9] and is usually not serious unless the infiltrated fluid ... the entire medication dose is flushed through the IV tubing from the mainline bag. Because of its design, the short, secondary ...
Possible consequences include hypertension, heart failure, and pulmonary edema. Hypothermia[edit]. The human body is at risk of ... Infection, and a foreign body embolus are the two threats to the patient.[citation needed] ... Shearing occurs when part of the catheter is cut by the sharp bevelled edge of the trochar. The sheared section may completely ... Infiltration is one of the most common adverse effects of IV therapy[10] and is usually not serious unless the infiltrated ...
... which becomes desensitized in cases of heart failure, paroxetine (or a paroxetine derivative) could be used as a heart failure ... "Paxil, Paxil CR (paroxetine) dosing, indications, interactions, adverse effects, and more". Medscape Reference. WebMD. ... Wikipedia articles needing page number citations from January 2017. *Commons category link from Wikidata ... This side effect can occur in individuals with no history of mania but it may be more likely to occur in those with bipolar or ...
"Domperidone - heart rate and rhythm disorders." Canadian adverse reactions newsletter. Government of Canada. January 2007 17(1) ... in elderly people and in high doses (, 30 mg per day).[20] A clinical sign of domperidone's potential toxicity to the heart is ... Although these features make domperidone a useful drug in Parkinson's disease, caution is needed due to the cardiotoxic side ... The maximum effect occurs after 2 or 3 weeks of treatment, and the treatment period generally lasts for 3 to 8 weeks.[30] A ...
Examples of comorbidities include heart failure, COPD, neuromuscular disease. Use the ASA Classification to predict a patient's ... Similar to previously described, consider starting with a smaller dose, giving the medication slowly, and giving repeat doses ... This section needs expansion. You can help by adding to it. (January 2012) ... Effects occur within 30 seconds, and last 5-20 minutes.[6] Ketamine has sedative, analgesic, and amnestic properties, but most ...
Bendz, Hans; Schön, Staffan; Attman, Per-Ola; Aurell, Mattias (1 February 2010). "Renal failure occurs in chronic lithium ... Most side effects of lithium are dose-dependent. The lowest effective dose is used to limit the risk of side effects. ... Adverse effectsEdit. Sources for the following lists.[22][23][24][25][26][27][28] ... 2005.[page needed] *^ Rosenberg, J.; Salzman, C. (2007). "Update: New uses for lithium and anticonvulsants". CNS Spectrums. 12 ...
If this does not occur, however, possible adverse outcomes include palpitations, dizziness, lightheadedness (during shorter ... medical citation needed] Hypokalemia (low blood potassium) Hypomagnesemia (low blood magnesium) Hypocalcemia (low blood calcium ... Heart failure Left ventricular hypertrophy Hypothermia Subarachnoid hemorrhage Hypothyroidism The ECG tracing in torsades ... related to a potential risk of abnormal heart rhythms with high doses" (Press release). USFDA. February 15, 2013. Retrieved ...
... citation needed] Death usually occurs within two to six hours in fatal poisoning (20 to 40 mL of tincture may prove fatal). The ... Tingling will start at the point of absorption and extend up the arm to the shoulder, after which the heart will start to be ... Marked symptoms may appear almost immediately, usually not later than one hour, and "with large doses death is almost ... Other drugs used for ventricular arrhythmia include lidocaine, amiodarone, bretylium, flecainide, procainamide, and mexiletine ...
For the most critical effects, conduct an RCA to determine why the variation (the failure mode) leading to that effect occurs. ... To achieve this, a new health care delivery system is needed - a system that both prevents errors from occurring, and learns ... Root Cause Analyses search out latent or system failures that underlie adverse events or near misses. In 1997, JCAHO mandated ... Suggested Citation:"Appendix F: Quality Improvement and Proactive Hazard Analysis Models: Deciphering a New Tower of Babel." ...
... citation needed]. The inhibition of the sodium pump may also improve baroreceptor sensitivity in heart failure and may explain ... usually in 125-μg or 250-μg doses.[citation needed] ... The occurrence of adverse drug reactions is common, owing to ... Examples commonly used in patients with heart problems include spironolactone, verapamil and amiodarone. In patients with ... In overdose, the usual supportive measures are needed. If arrhythmias prove troublesome, or malignant hyperkalaemia occurs ( ...
Low dose erythropoietin improves cardiac function in experimental heart failure without increasing hematocrit. Eur J Heart Fail ... exacerbation of heart failure, and need for revascularization). More details of the methods can be found in the article and ... 7) Most of these beneficial effects occur independently from the dose of ESA and appear only partially related to hematocrit ... Citations Citation. Qaseem A, Humphrey LL, Fitterman N, Starkey M, Shekelle P, for the Clinical Guidelines Committee of the ...
6.1 Common Adverse Reactions. Hematopoietic system Neutropenia occurs in patients treated with cyclophosphamide. The degree of ... Myocarditis, myopericarditis, pericardial effusion including cardiac tamponade, and congestive heart failure, which may be ... 2.1 Dosing for Malignant Diseases 2.2 Dosing for Minimal Change Nephrotic Syndrome in Pediatric Patients 2.3 Handling and ... Amiodarone • G-CSF, GM-CSF (granulocyte colony-stimulating factor, granulocyte macrophage colony-stimulating factor): Reports ...
... of congestive hepatopathy secondary to underlying congestive heart failure which most of the patients needing amiodarone would ... Amiodarone is initially given at a higher dosage orally or IV termed as the loading dose followed by a daily maintenance dose ... Although acute toxic effect due to intravenous amiodarone is rare, but occurred once, it creates a true dilemma in the ... Citations to this Article. * How to Cite this Article. *Views 1,256. *Citations 1 ...
If heart rate ,50 bpm or signs and symptoms of bradycardia (dizziness, fatigue, hypotension) occur, decrease dose by 2.5 mg ... Adverse Reactions/Side Effects. CV: TORSADE DE POINTES, atrial fibrillation, bradycardia, heart block, hypertension, QT ... Lowering of heart rate with reduced need for hospitalization in HF patients. ... Citation. Quiring, Courtney, et al. "Ivabradine." Daviss Drug Guide, 16th ed., F.A. Davis Company, 2019. Washington Manual, ...
5.4 Heart Failure. New onset or worsening heart failure may occur during initiation or uptitration of sotalol because of its ... treated with 160 to 320 mg doses of sotalol hydrochloride, the following adverse reactions presented in Table 6 occurred in at ... received chronic oral amiodarone therapy for ,1 month within previous 12 weeks; congenital or acquired long QT syndromes; ... Application Number or Monograph Citation. Marketing Start Date. Marketing End Date. ANDA. ANDA075500. 02/15/2011. ...
... and the secondary outcome was the rate of adverse effects of cardiac origin due to vernakalant and the placebo or amiodarone. ... the efficacy of vernakalant comparing to other antiarrhythmic agents needing more well-designed double-blinded RCTs to be ... Owing to only one study comparing vernakalant with amiodarone included in this study, ... In analysing the adverse effects of cardiac origin, there was no significant difference between the two groups (RR= 0.90, 95% ...
Includes: indications, dosage, adverse reactions, pharmacology and more. ... Common Adverse Reactions. Hematopoietic system:. Neutropenia occurs in patients treated with cyclophosphamide. The degree of ... Monitoring of complete blood counts is essential during cyclophosphamide treatment so that the dose can be adjusted, if needed ... Myocarditis, myopericarditis, pericardial effusion including cardiac tamponade, and congestive heart failure, which may be ...
... and heart failure related hospitalizations and need for urgent care increased.. The DIG trial was a classically designed, large ... and amiodarone. When using digoxin a focus on low doses and serum levels is important, as enhancing parasympathetic effects is ... because of the slowing of AV conduction that occurs, precipitous acceleration of heart rate can develop with supraventricular ... Assessing Direct Costs of Treatment-Related Adverse Events in Advanced Melanoma. *New PDL1 Inhibitors for Non-small Cell Lung ...
Dose reduction or temporary discontinuation was permitted if limiting side effects occurred, but reinstitution of the protocol- ... The need for our work is beyond question. Find Out More about the American Heart Association ... Vasodilators may improve EF by altering loading conditions, but they also have the potential to activate adverse neurohormonal ... Citation Tools. Effect of Amiodarone on Clinical Status and Left Ventricular Function in Patients With Congestive Heart Failure ...
The scientific literature provides extensive evidence of widespread magnesium deficiency and the potential need for magnesium ... O. B. Stepura and A. I. Martynow, "Magnesium orotate in severe congestive heart failure (MACH)," International Journal of ... xxii) Nutraceuticals: for example, high-dose calcium, high-dose vitamin D, and caffeine. ... Food processing as occurs with many foods found in the everyday diet of people in the developed world, such as processed white ...
... and heart failure related hospitalizations and need for urgent care increased.. The DIG trial was a classically designed, large ... and amiodarone. When using digoxin a focus on low doses and serum levels is important, as enhancing parasympathetic effects is ... because of the slowing of AV conduction that occurs, precipitous acceleration of heart rate can develop with supraventricular ... For example, PubMed in the 1980 to 1985 window listed 1,911 citations for "digoxin" compared to only 766 in 2005 to 2010. ...
... the Atrial Fibrillation and Congestive Heart Failure (AF-CHF) trial. Am Heart J. 2002; 144: 597-607. ... The need for our work is beyond question. Find Out More about the American Heart Association ... AF that occurred during follow-up in the group without predischarge AF (but not in the group with predischarge AF) ... Cost-effectiveness of targeting patients undergoing cardiac surgery for therapy with intravenous amiodarone to prevent atrial ...
Those with heart disease have a higher risk of arrhythmia, heart failure, and other cardiovascular risks. ... but their medication may need adjusting as thyroxine dose requirements usually increase. Levothyroxine is safe to take during ... Options include amiodarone and lithium, used to treat bipolar disorder.. Thyroiditis. An inflammation of the thyroid that often ... What are thyroid nodules? Thyroid nodules are lumps that commonly occur in an otherwise normal thyroid gland, especially as ...
Amiodarone, Clonazepam, Mesalazine, Ethosuximide, Celecoxib, Domperidone, Cotinine, Cholic Acid, Chloroquine, Cefditoren, ... Amiodarone. Amiodarone is an antiarrhythmic agent (medication used for irregular heart beat) used for various types of ... When the dose is reduced or the drug is stopped these adaptions which have occurred when a persons body has become addicted to ... It was the first orally active neuraminidase inhibitor commercially developed.[citation needed] It was developed by C.U. Kim, W ...
... making it a useful tool in the diagnosis of cardiac failure and a strong prognostic factor in congestive heart failure [55]. ... High dose melphalan (140 to 200 mg/m2) followed by ASCT has been applied as a front line therapy for eligible patients since ... Citation: Dogan EE, Şahin F, Saydam G (2016) Amyloidosis: Laboratory and Clinical Perspectives. Med chem (Los Angeles) 6:270- ... Dispenzieri A, Gertz MA, Buadi F (2012) What do I need to know about immunoglobulin light chain (AL) amyloidosis? Blood Rev 26 ...
Short-term (,48 hr) management of heart failure caused by depressed contractility from organic heart disease or surgical ... Titrate to patient response (heart rate, presence of ectopic activity, BP, urine output, CVP, PCWP, cardiac index). Dose should ... Citation. Quiring, Courtney, et al. "DOBUTamine." Daviss Drug Guide, 16th ed., F.A. Davis Company, 2019. Nursing Central, ... If overdose occurs, reduction or discontinuation of therapy is the only treatment necessary because of the short duration of ...
Heart Rate Control in Patients With Heart Failure and Without Accessory Pathway. ... Amiodarone. Loading dose, then 200 mg daily. Class IIb, LOE C. a A class I indication means that the benefits of treatment far ... If dabigatran is not appropriate for J.K. because of cost, renal failure, or adverse effects, the 2011 focused update to the ... Get Citation Citation. Good ED, Rogers FJ. Patient-Centered Management of Atrial Fibrillation: Applying Evidence-Based Care to ...
Those with heart disease have a higher risk of arrhythmia, heart failure, and other cardiovascular risks. ... but their medication may need adjusting as thyroxine dose requirements usually increase. Levothyroxine is safe to take during ... Options include amiodarone and lithium, used to treat bipolar disorder.. Thyroiditis. An inflammation of the thyroid that often ... It affects women more than men and is most likely to occur over the age of 60 years. ...
Adverse drug events may occur due to changes in enzyme and neurotransmitter activity as well as specific receptor sites. Frail ... 5. Dosing frequency based on drug levels for antibiotics, such as vancomycin and aminoglycosides, may be needed initially in ... Drug accumulation with multiple doses of antiarrhythmics (e.g. amiodarone, carvedilol) may be more pronounced in renal and ... Citation:Brophy GM, Floroff CK, Harpe SE, Patricia W (2015) Critical Illness and the Aging Population: Clinical Implications ...
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The main adverse reaction is concentration-related nephrotoxicity.. Desipramine. 100-250 ng/mL. 13-23. No data on dose ... increased; ↓, decreased; ↔, unchanged; CNS, central nervous system; CYP, cytochrome P450; HF, heart failure; HPLC, high ... MLA Citation Nicoll C, Mark Lu C. Nicoll C, Mark Lu C Nicoll, C. Diana, and Chuanyi Mark Lu.. "Therapeutic Drug Monitoring & ... An error has occurred sending your email(s). Please try again later or contact an administrator at [email protected] ...
  • The American Heart Association's Get with the Guidelines coronary artery disease program is associated with improved care for men and women of all ages [abstract]. (jamanetwork.com)
  • not stopping placebo by Using Abstract on teaching failure through the ill supply. (augenta.net)
  • The inhibitor heart comprises that life is a more scientific density of PDE5 than local understood levels( greater than 80 oxygen for 345S-348S neurotransmitter, greater than 1,000 variety for PDE2, PDE3, and PDE4 Abstract). (augenta.net)
  • The occurrence of adverse drug reactions is common, owing to its narrow therapeutic index (the margin between effectiveness and toxicity ). (wikipedia.org)
  • To report SUSPECTED ADVERSE REACTIONS, contact West-Ward Pharmaceuticals Corp. at 1-800-962-8364 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch . (nih.gov)
  • To report SUSPECTED ADVERSE REACTIONS, contact Upsher-Smith Laboratories, LLC at 1-855-899-9180 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch. (nih.gov)
  • To reduce the likelihood of adverse reactions that appear to be administration rate-dependent (e.g., facial swelling, headache, nasal congestion, scalp burning), cyclophosphamide should be injected or infused very slowly. (drugs.com)
  • Adverse reactions: skin reactions, myelosuppression. (mhmedical.com)
  • Nondopaminergic adverse reactions mainly include diarrhea and abdominal pain. (deepdyve.com)
  • This month's column begins a series of discussions on important and universally underappreciated adverse drug reactions to fluoroquinolone antibiotics relevant to the EP. (lww.com)
  • While the majority of fluoroquinolones are well tolerated and have been proven to be excellent antimicrobials, the adverse reactions noted in the next few columns should be viewed as essential knowledge for emergency physicians. (lww.com)
  • We assessed the following sections of these documents for relevant information: "Summary Product Information," "Warnings and Precautions," "Contraindications," "Adverse Reactions," "Drug Interactions" and "Action and Clinical Pharmacology. (cmaj.ca)
  • AIH is due to failure to escape from the acute Wolff-Chaikoff effect and is easily treated with levothyroxine replacement without requiring amiodarone withdrawal. (springer.com)
  • There have been recent studies suggesting that high-dose statin therapy plays a plaque-stabilizing role in people suffering from acute coronary syndrome and thrombotic stroke. (wikipedia.org)
  • The following day, the patient rapidly developed fluid resistant shock, a severe metabolic acidosis, acute oliguric kidney failure, an elevated creatine kinase, and transaminases. (springeropen.com)
  • The leading cause of myocardial ischemia is represented by atherosclerotic CAD, affecting one or more epicardial coronaries, however other causes of myocardial ischemia, occurring in the absence of atherosclerotic obstructions of the vessels, such as cardiomyopathies or aortic stenosis, need to be mentioned as a cause of anginal pain. (clinmedjournals.org)
  • these are mostly relatively mild but, in rare cases, severe muscle damage with renal failure (rhabdomyolysis) may occur (reviewed in 5 , 6 ). (plos.org)
  • When cyclophosphamide is included in combined cytotoxic regimens, it may be necessary to reduce the dose of cyclophosphamide as well as that of the other drugs. (drugs.com)
  • 7% of population may be poor metabolizers and may have significantly ↑ metoprolol concentrations and an ↑ risk of adverse effects. (unboundmedicine.com)
  • Doses are adjusted to achieve plasma concentrations of 0.4 to 1.2 mmol Li + /l (lower end of the range for maintenance therapy and the elderly, higher end for children) on samples taken 12 hours after the preceding dose. (hitchhikersgui.de)
  • Maximal plasma concentrations were approximately 6 µM after a single dose of 200 mg entacapone and 17 µM after a single dose of 100 mg tolcapone (Kaakkola, 2000). (deepdyve.com)
  • RESULTS Tedisamil led to a dose dependent prolongation of exercise duration (significant at all concentrations), an effect that was greater at peak than at trough. (bmj.com)
  • externally, coronary valves and sensitive particle clinicians recommend reduced improved in Intracellular hormones in fibroin with mellitus section and Indirect present xenogeneic campaigns, treating that they develop in matter heart. (lbpack206.com)
  • Treatment is similar to poisoning caused by oral ingestion and even handling the plant without gloves has been reported to result in multi-organ failure and death. (wikipedia.org)
  • Without treatment, hyperthyroidism can seriously impact different bodily functions, including the heart. (medicalnewstoday.com)
  • Multiple factors influence the complexity of treatment strategies and create challenges for optimizing patient care while avoiding unwanted adverse effects . (omicsonline.org)
  • These factors include Pharmacokinetic (PK) and Pharmacodynamics (PD) changes that are compounded by both age and critical illnesses and may heighten the risk of suboptimal treatment strategies and adverse drug events, including neurotoxicity, to the patient. (omicsonline.org)
  • Iodine kinetic studies during amiodarone treatment. (springer.com)
  • The treatment regimen will start with a loading dose of 2 g/kg body weight over 2-4 consecutive days, followed by a maintenance dose of 1 g/kg body weight over 1-2 consecutive days given three times at a 3-week interval. (biomedcentral.com)
  • Intermittent treatment with 0.5% nebulizer solution (5 mg/mL): minimum dose 2.5 mg (0.5 mL) every 20 min for 3 doses, then 0.15-0.30 mg/kg up to 10 mg every 1-4 h as needed. (aappublications.org)
  • However, It is not recommended to combine statin medication treatment with certain other cholesterol-lowering medications, particularly fibrates , because this may increase the risk of myopathy-related adverse effects. (wikipedia.org)
  • Treatment consists of short-term or as-needed pharmacotherapy using calcium channel or beta blockers when vagal maneuvers fail to halt or slow the rhythm. (aafp.org)
  • Regarding tolcapone, hepatocellular injury is dose-dependent and usually occurs during the first 6 months of treatment (Olanow, 2000). (deepdyve.com)
  • Apoptosis: An risk in the treatment of functions in a failure or DNA, usually legal to function beta-oxidation. (worldclassbows.com)
  • Algorithms and Techniques: 8th International Workshop on Approximation Algorithms for: air of hypotheses to conduct the adherence's neurohormonal P. This relates any stress used for nuclear several j. transplantation: A Summary or language of Microorganisms filed to be the Organic treatment to interpret to a carvedilol or to hundreds, 3rd as citations or rays. (augenta.net)
  • The predefined composite end point consisted of the following AIT-associated complications: death, heart transplantation, hospitalization for heart failure, myocardial infarction, stroke, hospitalization for arrhythmia management, or hospitalization for treatment complications. (onlinejacc.org)
  • The American College of Cardiology (ACC) and the American Heart Association (AHA) jointly issued a new guideline in 2013 on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults. (aafp.org)
  • We will be this tension by including ADVERTISER and time Migration in the arterial muscle of the surgery during the clamp from infarction to treatment, and be strong effects to be single Mitral nuclei in adverse and pituitary section molecules. (augenta.net)
  • Heart failure is also expensive, costing the NHS about £360 million a year in diagnosis and management, 60% of which is spent on hospital treatment. (bmj.com)
  • Tedisamil also decreased (in a dose dependent way) the frequency of anginal attacks and the consumption of short acting nitrates, an improvement that became significant for all doses in the second treatment week. (bmj.com)
  • Provided are compositions comprising naturally occurring vesicles, hybrid vesicles and vesicle populations, and methods using vesicle compositions to deliver therapeutic molecules for the treatment of cardiovascular disease. (sumobrain.com)
  • The failure covers d of oneself or one is treatment and signs. (lbpack206.com)
  • Drugs that may induce or exacerbate parkinsonism include but are not limited to neuroleptics, antidepressants, calcium channel blockers, valproate, lithium, and amiodarone. (nih.gov)
  • Ranolazine is a novel antianginal agent, approved by the Food and Drug Administration in 2006, that, unlike beta-blockers, nitrates, or calcium channel blockers, does not affect either heart rate or blood pressure. (clinmedjournals.org)
  • This preferential effect is not absolute, however, and at higher doses, atenolol inhibits beta 2 -adrenoreceptors, chiefly located in the bronchial and vascular musculature. (nih.gov)
  • This is usually achieved through a metered dose inhaler, nebulizer or other proprietary delivery devices (e.g. (alsachim.com)
  • Metered-dose inhaler: 4-8 puffs (90 μg per puff) every 15-20 min for 3 doses. (aappublications.org)
  • A spacer/holding chamber must be used when administering metered-dose inhaler treatments. (aappublications.org)
  • 1. A composition comprising naturally occurring vesicles derived from a nucleated cell, wherein said naturally occurring vesicles comprise at least one therapeutic nucleic acid or polypeptide. (sumobrain.com)
  • 2. A composition comprising fusion vesicles derived in part from a naturally occurring vesicle, and in part from a synthetic vesicle, wherein said naturally occurring vesicle comprises at least one therapeutic nucleic acid or polypeptide and said synthetic vesicle comprises at least one therapeutic agent. (sumobrain.com)
  • A Cochrane review found that for every 1,000 persons treated with a statin for five years, 18 avoid myocardial infarction, angina, or stroke (number needed to treat = 56). (aafp.org)
  • This drug works by blocking the action of certain natural substances in your body, such as epinephrine, on the heart and blood vessels. (ndclist.com)
  • For both orally and intravenously administered drug, the duration of action is dose related and also bears a linear relationship to the logarithm of plasma atenolol concentration. (nih.gov)
  • In studies of the major chronic illnesses such as diabetes, arthritis, and hypertension, heart failure had the greatest negative impact on quality of life, and not just slightly so. (bmj.com)
  • Pulmonary hypertension ( PH ) is a group of life-threatening progressive diseases of various genesis, characterized by a progressive increase in arterial pressure ( AP ) in the pulmonary artery ( PA ), the remodeling of pulmonary vessels, which leads to an increase in pulmonary vascular resistance and pulmonary arterial pressure and more often leads to right ventricular heart failure and premature death. (pensoft.net)
  • Right heart function is the main determinant of prognosis in pulmonary arterial hypertension (PAH). (ersjournals.com)
  • The development of secondary LH is caused by congenital heart defects, collagenoses, presence of thrombus in the pulmonary artery, prolonged high pressure in the left atrium, hypoxemia, chronic obstructive pulmonary diseases ( COPD s). (pensoft.net)
  • In case of secondary PH , thrombosis and other changes in the pulmonary veins occur. (pensoft.net)
  • The disease is characterized by a progressive increase in pulmonary vascular resistance and hypertrophy of the right ventricle of the heart. (pensoft.net)