The introduction of whole blood or blood component directly into the blood stream. (Dorland, 27th ed)
Reinfusion of blood or blood products derived from the patient's own circulation. (Dorland, 27th ed)
The transfer of erythrocytes from a donor to a recipient or reinfusion to the donor.
Transplantation of an individual's own tissue from one site to another site.
The transfer of blood platelets from a donor to a recipient or reinfusion to the donor.
Repetitive withdrawal of small amounts of blood and replacement with donor blood until a large proportion of the blood volume has been exchanged. Used in treatment of fetal erythroblastosis, hepatic coma, sickle cell anemia, disseminated intravascular coagulation, septicemia, burns, thrombotic thrombopenic purpura, and fulminant malaria.
Loss of blood during a surgical procedure.
The transfer of blood components such as erythrocytes, leukocytes, platelets, and plasma from a donor to a recipient or back to the donor. This process differs from the procedures undertaken in PLASMAPHERESIS and types of CYTAPHERESIS; (PLATELETPHERESIS and LEUKAPHERESIS) where, following the removal of plasma or the specific cell components, the remainder is transfused back to the donor.
In utero transfusion of BLOOD into the FETUS for the treatment of FETAL DISEASES, such as fetal erythroblastosis (ERYTHROBLASTOSIS, FETAL).
Centers for collecting, characterizing and storing human blood.
Testing erythrocytes to determine presence or absence of blood-group antigens, testing of serum to determine the presence or absence of antibodies to these antigens, and selecting biocompatible blood by crossmatching samples from the donor against samples from the recipient. Crossmatching is performed prior to transfusion.
Recovery of blood lost from surgical procedures for reuse by the same patient in AUTOLOGOUS BLOOD TRANSFUSIONS. It is collected during (intraoperatively) or after completion of (postoperatively) the surgical procedures.
Passage of blood from one fetus to another via an arteriovenous communication or other shunt, in a monozygotic twin pregnancy. It results in anemia in one twin and polycythemia in the other. (Lee et al., Wintrobe's Clinical Hematology, 9th ed, p737-8)
A reduction in the number of circulating ERYTHROCYTES or in the quantity of HEMOGLOBIN.
Hemorrhage following any surgical procedure. It may be immediate or delayed and is not restricted to the surgical wound.
Antifibrinolytic hemostatic used in severe hemorrhage.
The oxygen-carrying proteins of ERYTHROCYTES. They are found in all vertebrates and some invertebrates. The number of globin subunits in the hemoglobin quaternary structure differs between species. Structures range from monomeric to a variety of multimeric arrangements.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Agents that prevent fibrinolysis or lysis of a blood clot or thrombus. Several endogenous antiplasmins are known. The drugs are used to control massive hemorrhage and in other coagulation disorders.
Patient care procedures performed during the operation that are ancillary to the actual surgery. It includes monitoring, fluid therapy, medication, transfusion, anesthesia, radiography, and laboratory tests.
Members of a religious denomination founded in the United States during the late 19th century in which active evangelism is practiced, the imminent approach of the millennium is preached, and war and organized government authority in matters of conscience are strongly opposed (from American Heritage Dictionary of the English Language, 4th ed). Jehovah's Witnesses generally refuse blood transfusions and other blood-based treatments based on religious belief.
The process by which blood or its components are kept viable outside of the organism from which they are derived (i.e., kept from decay by means of a chemical agent, cooling, or a fluid substitute that mimics the natural state within the organism).
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
An antigenic mismatch between donor and recipient blood. Antibodies present in the recipient's serum may be directed against antigens in the donor product. Such a mismatch may result in a transfusion reaction in which, for example, donor blood is hemolyzed. (From Saunders Dictionary & Encyclopedia of Laboratory Medicine and Technology, 1984).
The transfer of leukocytes from a donor to a recipient or reinfusion to the donor.
Reduction of blood viscosity usually by the addition of cell free solutions. Used clinically (1) in states of impaired microcirculation, (2) for replacement of intraoperative blood loss without homologous blood transfusion, and (3) in cardiopulmonary bypass and hypothermia.
The degree to which the blood supply for BLOOD TRANSFUSIONS is free of harmful substances or infectious agents, and properly typed and crossmatched (BLOOD GROUPING AND CROSSMATCHING) to insure serological compatibility between BLOOD DONORS and recipients.
The mildest form of erythroblastosis fetalis in which anemia is the chief manifestation.
The preparation of platelet concentrates with the return of red cells and platelet-poor plasma to the donor.
Interventions to provide care prior to, during, and immediately after surgery.
Elements of limited time intervals, contributing to particular results or situations.
Transfer of HEMATOPOIETIC STEM CELLS from BONE MARROW or BLOOD between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). Hematopoietic stem cell transplantation has been used as an alternative to BONE MARROW TRANSPLANTATION in the treatment of a variety of neoplasms.
Substances that are used in place of blood, for example, as an alternative to BLOOD TRANSFUSIONS after blood loss to restore BLOOD VOLUME and oxygen-carrying capacity to the blood circulation, or to perfuse isolated organs.
Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
A disorder characterized by reduced synthesis of the beta chains of hemoglobin. There is retardation of hemoglobin A synthesis in the heterozygous form (thalassemia minor), which is asymptomatic, while in the homozygous form (thalassemia major, Cooley's anemia, Mediterranean anemia, erythroblastic anemia), which can result in severe complications and even death, hemoglobin A synthesis is absent.
Antibodies from an individual that react with ISOANTIGENS of another individual of the same species.
Glycoprotein hormone, secreted chiefly by the KIDNEY in the adult and the LIVER in the FETUS, that acts on erythroid stem cells of the BONE MARROW to stimulate proliferation and differentiation.
A condition characterized by the abnormal presence of ERYTHROBLASTS in the circulation of the FETUS or NEWBORNS. It is a disorder due to BLOOD GROUP INCOMPATIBILITY, such as the maternal alloimmunization by fetal antigen RH FACTORS leading to HEMOLYSIS of ERYTHROCYTES, hemolytic anemia (ANEMIA, HEMOLYTIC), general edema (HYDROPS FETALIS), and SEVERE JAUNDICE IN NEWBORN.
The transference of BONE MARROW from one human or animal to another for a variety of purposes including HEMATOPOIETIC STEM CELL TRANSPLANTATION or MESENCHYMAL STEM CELL TRANSPLANTATION.
Agents acting to arrest the flow of blood. Absorbable hemostatics arrest bleeding either by the formation of an artificial clot or by providing a mechanical matrix that facilitates clotting when applied directly to the bleeding surface. These agents function more at the capillary level and are not effective at stemming arterial or venous bleeding under any significant intravascular pressure.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
A disease characterized by chronic hemolytic anemia, episodic painful crises, and pathologic involvement of many organs. It is the clinical expression of homozygosity for hemoglobin S.
Bleeding or escape of blood from a vessel.
The removal of LEUKOCYTES from BLOOD to reduce BLOOD TRANSFUSION reactions and lower the chance of transmitting VIRUSES. This may be performed by FILTRATION or by CYTAPHERESIS.
Control of bleeding during or after surgery.
Care given during the period prior to undergoing surgery when psychological and physical preparations are made according to the special needs of the individual patient. This period spans the time between admission to the hospital to the time the surgery begins. (From Dictionary of Health Services Management, 2d ed)
International collective of humanitarian organizations led by volunteers and guided by its Congressional Charter and the Fundamental Principles of the International Red Cross Movement, to provide relief to victims of disaster and help people prevent, prepare for, and respond to emergencies.
Surgery which could be postponed or not done at all without danger to the patient. Elective surgery includes procedures to correct non-life-threatening medical problems as well as to alleviate conditions causing psychological stress or other potential risk to patients, e.g., cosmetic or contraceptive surgery.
The period of care beginning when the patient is removed from surgery and aimed at meeting the patient's psychological and physical needs directly after surgery. (From Dictionary of Health Services Management, 2d ed)
Diversion of the flow of blood from the entrance of the right atrium directly to the aorta (or femoral artery) via an oxygenator thus bypassing both the heart and lungs.
Transplacental passage of fetal blood into the circulation of the maternal organism. (Dorland, 27th ed)
The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.
Transplantation between individuals of the same species. Usually refers to genetically disparate individuals in contradistinction to isogeneic transplantation for genetically identical individuals.
The number of PLATELETS per unit volume in a sample of venous BLOOD.
Infectious organisms in the BLOOD, of which the predominant medical interest is their contamination of blood-soiled linens, towels, gowns, BANDAGES, other items from individuals in risk categories, NEEDLES and other sharp objects, MEDICAL WASTE and DENTAL WASTE, all of which health workers are exposed to. This concept is differentiated from the clinical conditions of BACTEREMIA; VIREMIA; and FUNGEMIA where the organism is present in the blood of a patient as the result of a natural infectious process.
INFLAMMATION of the LIVER in humans caused by HEPATITIS C VIRUS, a single-stranded RNA virus. Its incubation period is 30-90 days. Hepatitis C is transmitted primarily by contaminated blood parenterally, and is often associated with transfusion and intravenous drug abuse. However, in a significant number of cases, the source of hepatitis C infection is unknown.
Replacement of the knee joint.
A single-chain polypeptide derived from bovine tissues consisting of 58 amino-acid residues. It is an inhibitor of proteolytic enzymes including CHYMOTRYPSIN; KALLIKREIN; PLASMIN; and TRYPSIN. It is used in the treatment of HEMORRHAGE associated with raised plasma concentrations of plasmin. It is also used to reduce blood loss and transfusion requirements in patients at high risk of major blood loss during and following open heart surgery with EXTRACORPOREAL CIRCULATION. (Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Englewood, CO, 1995)
The process by which fetal Rh+ erythrocytes enter the circulation of an Rh- mother, causing her to produce IMMUNOGLOBULIN G antibodies, which can cross the placenta and destroy the erythrocytes of Rh+ fetuses. Rh isoimmunization can also be caused by BLOOD TRANSFUSION with mismatched blood.
Agents which improve the quality of the blood, increasing the hemoglobin level and the number of erythrocytes. They are used in the treatment of anemias.
The residual portion of BLOOD that is left after removal of BLOOD CELLS by CENTRIFUGATION without prior BLOOD COAGULATION.
The period of confinement of a patient to a hospital or other health facility.
Bleeding in any segment of the GASTROINTESTINAL TRACT from ESOPHAGUS to RECTUM.
Surgery performed on the heart.
A subnormal level of BLOOD PLATELETS.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
An infant during the first month after birth.
An excessive accumulation of iron in the body due to a greater than normal absorption of iron from the gastrointestinal tract or from parenteral injection. This may arise from idiopathic hemochromatosis, excessive iron intake, chronic alcoholism, certain types of refractory anemia, or transfusional hemosiderosis. (From Churchill's Illustrated Medical Dictionary, 1989)
Therapy of heavy metal poisoning using agents which sequester the metal from organs or tissues and bind it firmly within the ring structure of a new compound which can be eliminated from the body.
Excess blood loss from uterine bleeding associated with OBSTETRIC LABOR or CHILDBIRTH. It is defined as blood loss greater than 500 ml or of the amount that adversely affects the maternal physiology, such as BLOOD PRESSURE and HEMATOCRIT. Postpartum hemorrhage is divided into two categories, immediate (within first 24 hours after birth) or delayed (after 24 hours postpartum).
Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. The only common feature among these tumors is the absence of giant REED-STERNBERG CELLS, a characteristic of Hodgkin's disease.
Operations carried out for the correction of deformities and defects, repair of injuries, and diagnosis and cure of certain diseases. (Taber, 18th ed.)
A group of hereditary hemolytic anemias in which there is decreased synthesis of one or more hemoglobin polypeptide chains. There are several genetic types with clinical pictures ranging from barely detectable hematologic abnormality to severe and fatal anemia.
Antibodies to the HEPATITIS C ANTIGENS including antibodies to envelope, core, and non-structural proteins.
Hemorrhagic and thrombotic disorders that occur as a consequence of abnormalities in blood coagulation due to a variety of factors such as COAGULATION PROTEIN DISORDERS; BLOOD PLATELET DISORDERS; BLOOD PROTEIN DISORDERS or nutritional conditions.
The transfer of STEM CELLS from one individual to another within the same species (TRANSPLANTATION, HOMOLOGOUS) or between species (XENOTRANSPLANTATION), or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). The source and location of the stem cells determines their potency or pluripotency to differentiate into various cell types.
The volume of packed RED BLOOD CELLS in a blood specimen. The volume is measured by centrifugation in a tube with graduated markings, or with automated blood cell counters. It is an indicator of erythrocyte status in disease. For example, ANEMIA shows a low value; POLYCYTHEMIA, a high value.
The techniques used to draw blood from a vein for diagnostic purposes or for treatment of certain blood disorders such as erythrocytosis, hemochromatosis, polycythemia vera, and porphyria cutanea tarda.
The number of RETICULOCYTES per unit volume of BLOOD. The values are expressed as a percentage of the ERYTHROCYTE COUNT or in the form of an index ("corrected reticulocyte index"), which attempts to account for the number of circulating erythrocytes.
A distribution in which a variable is distributed like the sum of the squares of any given independent random variable, each of which has a normal distribution with mean of zero and variance of one. The chi-square test is a statistical test based on comparison of a test statistic to a chi-square distribution. The oldest of these tests are used to detect whether two or more population distributions differ from one another.
The survival of a graft in a host, the factors responsible for the survival and the changes occurring within the graft during growth in the host.
Excision of all or part of the liver. (Dorland, 28th ed)
Replacement of the hip joint.
The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.
The number of LEUKOCYTES and ERYTHROCYTES per unit volume in a sample of venous BLOOD. A complete blood count (CBC) also includes measurement of the HEMOGLOBIN; HEMATOCRIT; and ERYTHROCYTE INDICES.
Red blood cells. Mature erythrocytes are non-nucleated, biconcave disks containing HEMOGLOBIN whose function is to transport OXYGEN.
An antifibrinolytic agent that acts by inhibiting plasminogen activators which have fibrinolytic properties.
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
INFLAMMATION of the LIVER in humans due to infection by VIRUSES. There are several significant types of human viral hepatitis with infection caused by enteric-transmission (HEPATITIS A; HEPATITIS E) or blood transfusion (HEPATITIS B; HEPATITIS C; and HEPATITIS D).
An alkylating nitrogen mustard that is used as an antineoplastic in the form of the levo isomer - MELPHALAN, the racemic mixture - MERPHALAN, and the dextro isomer - MEDPHALAN; toxic to bone marrow, but little vesicant action; potential carcinogen.
The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.
The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)
A rare transmissible encephalopathy most prevalent between the ages of 50 and 70 years. Affected individuals may present with sleep disturbances, personality changes, ATAXIA; APHASIA, visual loss, weakness, muscle atrophy, MYOCLONUS, progressive dementia, and death within one year of disease onset. A familial form exhibiting autosomal dominant inheritance and a new variant CJD (potentially associated with ENCEPHALOPATHY, BOVINE SPONGIFORM) have been described. Pathological features include prominent cerebellar and cerebral cortical spongiform degeneration and the presence of PRIONS. (From N Engl J Med, 1998 Dec 31;339(27))
A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.
Bleeding from a PEPTIC ULCER that can be located in any segment of the GASTROINTESTINAL TRACT.
EPIDEMIOLOGIC STUDIES based on the detection through serological testing of characteristic change in the serum level of specific ANTIBODIES. Latent subclinical infections and carrier states can thus be detected in addition to clinically overt cases.
Measure of histocompatibility at the HL-A locus. Peripheral blood lymphocytes from two individuals are mixed together in tissue culture for several days. Lymphocytes from incompatible individuals will stimulate each other to proliferate significantly (measured by tritiated thymidine uptake) whereas those from compatible individuals will not. In the one-way MLC test, the lymphocytes from one of the individuals are inactivated (usually by treatment with MITOMYCIN or radiation) thereby allowing only the untreated remaining population of cells to proliferate in response to foreign histocompatibility antigens.
The return of a sign, symptom, or disease after a remission.
An autologous or commercial tissue adhesive containing FIBRINOGEN and THROMBIN. The commercial product is a two component system from human plasma that contains more than fibrinogen and thrombin. The first component contains highly concentrated fibrinogen, FACTOR VIII, fibronectin, and traces of other plasma proteins. The second component contains thrombin, calcium chloride, and antifibrinolytic agents such as APROTININ. Mixing of the two components promotes BLOOD CLOTTING and the formation and cross-linking of fibrin. The tissue adhesive is used for tissue sealing, HEMOSTASIS, and WOUND HEALING.
The period during a surgical operation.
The indelible marking of TISSUES, primarily SKIN, by pricking it with NEEDLES to imbed various COLORING AGENTS. Tattooing of the CORNEA is done to colorize LEUKOMA spots.
The number of RED BLOOD CELLS per unit volume in a sample of venous BLOOD.
Erythrocyte isoantigens of the Rh (Rhesus) blood group system, the most complex of all human blood groups. The major antigen Rh or D is the most common cause of erythroblastosis fetalis.
The removal of fluids or discharges from the body, such as from a wound, sore, or cavity.
INFLAMMATION of the LIVER in humans caused by a member of the ORTHOHEPADNAVIRUS genus, HEPATITIS B VIRUS. It is primarily transmitted by parenteral exposure, such as transfusion of contaminated blood or blood products, but can also be transmitted via sexual or intimate personal contact.
A set of techniques used when variation in several variables has to be studied simultaneously. In statistics, multivariate analysis is interpreted as any analytic method that allows simultaneous study of two or more dependent variables.
Organic chemicals that form two or more coordination links with an iron ion. Once coordination has occurred, the complex formed is called a chelate. The iron-binding porphyrin group of hemoglobin is an example of a metal chelate found in biological systems.
The religion stemming from the life, teachings, and death of Jesus Christ: the religion that believes in God as the Father Almighty who works redemptively through the Holy Spirit for men's salvation and that affirms Jesus Christ as Lord and Savior who proclaimed to man the gospel of salvation. (From Webster, 3d ed)
Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. It has been used in the treatment of LYMPHOMA and LEUKEMIA. Its side effect, ALOPECIA, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.
A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. Other features include ANEMIA; HYPERCALCEMIA; and RENAL INSUFFICIENCY.
Endoscopic examination, therapy or surgery of the fetus and amniotic cavity through abdominal or uterine entry.
Proteins prepared by recombinant DNA technology.
Complications that affect patients during surgery. They may or may not be associated with the disease for which the surgery is done, or within the same surgical procedure.
The senescence of RED BLOOD CELLS. Lacking the organelles that make protein synthesis possible, the mature erythrocyte is incapable of self-repair, reproduction, and carrying out certain functions performed by other cells. This limits the average life span of an erythrocyte to 120 days.
Acquired hemolytic anemia due to the presence of AUTOANTIBODIES which agglutinate or lyse the patient's own RED BLOOD CELLS.
Antigens determined by leukocyte loci found on chromosome 6, the major histocompatibility loci in humans. They are polypeptides or glycoproteins found on most nucleated cells and platelets, determine tissue types for transplantation, and are associated with certain diseases.
Studies to determine the advantages or disadvantages, practicability, or capability of accomplishing a projected plan, study, or project.
Techniques for the removal of subpopulations of cells (usually residual tumor cells) from the bone marrow ex vivo before it is infused. The purging is achieved by a variety of agents including pharmacologic agents, biophysical agents (laser photoirradiation or radioisotopes) and immunologic agents. Bone marrow purging is used in both autologous and allogeneic BONE MARROW TRANSPLANTATION.
The destruction of ERYTHROCYTES by many different causal agents such as antibodies, bacteria, chemicals, temperature, and changes in tonicity.
Bleeding from the nose.
Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.
Solutions having the same osmotic pressure as blood serum, or another solution with which they are compared. (From Grant & Hackh's Chemical Dictionary, 5th ed & Dorland, 28th ed)
Damage inflicted on the body as the direct or indirect result of an external force, with or without disruption of structural continuity.
Antigens that exist in alternative (allelic) forms in a single species. When an isoantigen is encountered by species members who lack it, an immune response is induced. Typical isoantigens are the BLOOD GROUP ANTIGENS.
A form of anemia in which the bone marrow fails to produce adequate numbers of peripheral blood elements.
Transplantation of stem cells collected from the peripheral blood. It is a less invasive alternative to direct marrow harvesting of hematopoietic stem cells. Enrichment of stem cells in peripheral blood can be achieved by inducing mobilization of stem cells from the BONE MARROW.
The major human blood type system which depends on the presence or absence of two antigens A and B. Type O occurs when neither A nor B is present and AB when both are present. A and B are genetic factors that determine the presence of enzymes for the synthesis of certain glycoproteins mainly in the red cell membrane.
Preparative treatment of transplant recipient with various conditioning regimens including radiation, immune sera, chemotherapy, and/or immunosuppressive agents, prior to transplantation. Transplantation conditioning is very common before bone marrow transplantation.
Sets of cell surface antigens located on BLOOD CELLS. They are usually membrane GLYCOPROTEINS or GLYCOLIPIDS that are antigenically distinguished by their carbohydrate moieties.
A human infant born before 37 weeks of GESTATION.
The aggregate of various economic, political, and social policies by which an imperial power maintains or extends its control over other areas or peoples. It includes the practice of or belief in acquiring and retaining colonies. The emphasis is less on its identity as an ideological political system than on its designation in a period of history. (Webster, 3d ed; from Dr. J. Cassedy, NLM History of Medicine Division)
Surgical procedure involving either partial or entire removal of the spleen.
The phenomenon of target cell destruction by immunologically active effector cells. It may be brought about directly by sensitized T-lymphocytes or by lymphoid or myeloid "killer" cells, or it may be mediated by cytotoxic antibody, cytotoxic factor released by lymphoid cells, or complement.
Any liquid used to replace blood plasma, usually a saline solution, often with serum albumins, dextrans or other preparations. These substances do not enhance the oxygen- carrying capacity of blood, but merely replace the volume. They are also used to treat dehydration.
A test to detect non-agglutinating ANTIBODIES against ERYTHROCYTES by use of anti-antibodies (the Coombs' reagent.) The direct test is applied to freshly drawn blood to detect antibody bound to circulating red cells. The indirect test is applied to serum to detect the presence of antibodies that can bind to red blood cells.
Use of a thrombelastograph, which provides a continuous graphic record of the physical shape of a clot during fibrin formation and subsequent lysis.
Non-nucleated disk-shaped cells formed in the megakaryocyte and found in the blood of all mammals. They are mainly involved in blood coagulation.
Statistical models which describe the relationship between a qualitative dependent variable (that is, one which can take only certain discrete values, such as the presence or absence of a disease) and an independent variable. A common application is in epidemiology for estimating an individual's risk (probability of a disease) as a function of a given risk factor.
Therapeutic act or process that initiates a response to a complete or partial remission level.
Conditions in which there is a generalized increase in the iron stores of body tissues, particularly of liver and the MONONUCLEAR PHAGOCYTE SYSTEM, without demonstrable tissue damage. The name refers to the presence of stainable iron in the tissue in the form of hemosiderin.
A vital statistic measuring or recording the rate of death from any cause in hospitalized populations.
Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.
A condition of lung damage that is characterized by bilateral pulmonary infiltrates (PULMONARY EDEMA) rich in NEUTROPHILS, and in the absence of clinical HEART FAILURE. This can represent a spectrum of pulmonary lesions, endothelial and epithelial, due to numerous factors (physical, chemical, or biological).
Disease having a short and relatively severe course.
The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases, new or old, in the population at a given time.
The insertion of a catheter through the skin and body wall into the kidney pelvis, mainly to provide urine drainage where the ureter is not functional. It is used also to remove or dissolve renal calculi and to diagnose ureteral obstruction.
A repeat operation for the same condition in the same patient due to disease progression or recurrence, or as followup to failed previous surgery.
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
The taking of a blood sample to determine its character as a whole, to identify levels of its component cells, chemicals, gases, or other constituents, to perform pathological examination, etc.
The time periods immediately before, during and following a surgical operation.
Specialized hospital facilities which provide diagnostic and therapeutic services for trauma patients.
Agents used to prevent or reverse the pathological events leading to sickling of erythrocytes in sickle cell conditions.
A space in which the pressure is far below atmospheric pressure so that the remaining gases do not affect processes being carried on in the space.
Morphologic alteration of small B LYMPHOCYTES or T LYMPHOCYTES in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by INTERLEUKINS; MITOGENS such as PHYTOHEMAGGLUTININS, and by specific ANTIGENS. It may also occur in vivo as in GRAFT REJECTION.
Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.
Volume of circulating BLOOD. It is the sum of the PLASMA VOLUME and ERYTHROCYTE VOLUME.
Measurement of hemoglobin concentration in blood.
Identification of the major histocompatibility antigens of transplant DONORS and potential recipients, usually by serological tests. Donor and recipient pairs should be of identical ABO blood group, and in addition should be matched as closely as possible for HISTOCOMPATIBILITY ANTIGENS in order to minimize the likelihood of allograft rejection. (King, Dictionary of Genetics, 4th ed)
A class of statistical methods applicable to a large set of probability distributions used to test for correlation, location, independence, etc. In most nonparametric statistical tests, the original scores or observations are replaced by another variable containing less information. An important class of nonparametric tests employs the ordinal properties of the data. Another class of tests uses information about whether an observation is above or below some fixed value such as the median, and a third class is based on the frequency of the occurrence of runs in the data. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1284; Corsini, Concise Encyclopedia of Psychology, 1987, p764-5)
Organized procedures for establishing patient identity, including use of bracelets, etc.
A cell-cycle phase nonspecific alkylating antineoplastic agent. It is used in the treatment of brain tumors and various other malignant neoplasms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p462) This substance may reasonably be anticipated to be a carcinogen according to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (From Merck Index, 11th ed)
Immunized T-lymphocytes which can directly destroy appropriate target cells. These cytotoxic lymphocytes may be generated in vitro in mixed lymphocyte cultures (MLC), in vivo during a graft-versus-host (GVH) reaction, or after immunization with an allograft, tumor cell or virally transformed or chemically modified target cell. The lytic phenomenon is sometimes referred to as cell-mediated lympholysis (CML). These CD8-positive cells are distinct from NATURAL KILLER CELLS and NATURAL KILLER T-CELLS. There are two effector phenotypes: TC1 and TC2.
A disease or state in which death is possible or imminent.
A procedure in which a laparoscope (LAPAROSCOPES) is inserted through a small incision near the navel to examine the abdominal and pelvic organs in the PERITONEAL CAVITY. If appropriate, biopsy or surgery can be performed during laparoscopy.
Acute hemorrhage or excessive fluid loss resulting in HYPOVOLEMIA.
Any procedure in which blood is withdrawn from a donor, a portion is separated and retained and the remainder is returned to the donor.
A detailed review and evaluation of selected clinical records by qualified professional personnel for evaluating quality of medical care.
The total number of cases of a given disease in a specified population at a designated time. It is differentiated from INCIDENCE, which refers to the number of new cases in the population at a given time.
Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form.
Yellow discoloration of the SKIN; MUCOUS MEMBRANE; and SCLERA in the NEWBORN. It is a sign of NEONATAL HYPERBILIRUBINEMIA. Most cases are transient self-limiting (PHYSIOLOGICAL NEONATAL JAUNDICE) occurring in the first week of life, but some can be a sign of pathological disorders, particularly LIVER DISEASES.
A mucosal tumor of the urinary bladder or nasal cavity in which proliferating epithelium is invaginated beneath the surface and is more smoothly rounded than in other papillomas. (Stedman, 25th ed)
Period after successful treatment in which there is no appearance of the symptoms or effects of the disease.
A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle.
The body fluid that circulates in the vascular system (BLOOD VESSELS). Whole blood includes PLASMA and BLOOD CELLS.
The preparation of leukocyte concentrates with the return of red cells and leukocyte-poor plasma to the donor.
Acquired degenerative dilation or expansion (ectasia) of normal BLOOD VESSELS, often associated with aging. They are isolated, tortuous, thin-walled vessels and sources of bleeding. They occur most often in mucosal capillaries of the GASTROINTESTINAL TRACT leading to GASTROINTESTINAL HEMORRHAGE and ANEMIA.
A species of protozoa infecting humans via the intermediate tick vector IXODES scapularis. The other hosts are the mouse PEROMYSCUS leucopus and meadow vole MICROTUS pennsylvanicus, which are fed on by the tick. Other primates can be experimentally infected with Babesia microti.
Therapy for the insufficient cleansing of the BLOOD by the kidneys based on dialysis and including hemodialysis, PERITONEAL DIALYSIS, and HEMODIAFILTRATION.
The release of stem cells from the bone marrow into the peripheral blood circulation for the purpose of leukapheresis, prior to stem cell transplantation. Hematopoietic growth factors or chemotherapeutic agents often are used to stimulate the mobilization.
The number of WHITE BLOOD CELLS per unit volume in venous BLOOD. A differential leukocyte count measures the relative numbers of the different types of white cells.
Laboratory tests for evaluating the individual's clotting mechanism.
Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.
A malignant disease characterized by progressive enlargement of the lymph nodes, spleen, and general lymphoid tissue. In the classical variant, giant usually multinucleate Hodgkin's and REED-STERNBERG CELLS are present; in the nodular lymphocyte predominant variant, lymphocytic and histiocytic cells are seen.
Organic and inorganic compounds that contain iron as an integral part of the molecule.
A process of separating particulate matter from a fluid, such as air or a liquid, by passing the fluid carrier through a medium that will not pass the particulates. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
A metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN.
The restoration to life or consciousness of one apparently dead. (Dorland, 27th ed)
White blood cells formed in the body's lymphoid tissue. The nucleus is round or ovoid with coarse, irregularly clumped chromatin while the cytoplasm is typically pale blue with azurophilic (if any) granules. Most lymphocytes can be classified as either T or B (with subpopulations of each), or NATURAL KILLER CELLS.
Precise and detailed plans for the study of a medical or biomedical problem and/or plans for a regimen of therapy.
A glycoprotein of MW 25 kDa containing internal disulfide bonds. It induces the survival, proliferation, and differentiation of neutrophilic granulocyte precursor cells and functionally activates mature blood neutrophils. Among the family of colony-stimulating factors, G-CSF is the most potent inducer of terminal differentiation to granulocytes and macrophages of leukemic myeloid cell lines.
A condition of inadequate circulating red blood cells (ANEMIA) or insufficient HEMOGLOBIN due to premature destruction of red blood cells (ERYTHROCYTES).
Surgery performed on the ear and its parts, the nose and nasal cavity, or the throat, including surgery of the adenoids, tonsils, pharynx, and trachea.
The black, tarry, foul-smelling FECES that contain degraded blood.
The transmission of infectious disease or pathogens. When transmission is within the same species, the mode can be horizontal or vertical (INFECTIOUS DISEASE TRANSMISSION, VERTICAL).
Freedom from exposure to danger and protection from the occurrence or risk of injury or loss. It suggests optimal precautions in the workplace, on the street, in the home, etc., and includes personal safety as well as the safety of property.
A genus of FLAVIVIRIDAE causing parenterally-transmitted HEPATITIS C which is associated with transfusions and drug abuse. Hepatitis C virus is the type species.
The transference of a kidney from one human or animal to another.
Surgical therapy of ischemic coronary artery disease achieved by grafting a section of saphenous vein, internal mammary artery, or other substitute between the aorta and the obstructed coronary artery distal to the obstructive lesion.
A therapeutic approach, involving chemotherapy, radiation therapy, or surgery, after initial regimens have failed to lead to improvement in a patient's condition. Salvage therapy is most often used for neoplastic diseases.
... transfuse products made from allogeneic blood and they also make use of pre-donated blood for autologous transfusion. Interest ... HBOC's such as Polyheme and Hemepure have been discontinued due to severe adverse reactions including death. South Africa was ... but the technique is not an option for patients who refuse autologous blood transfusions. Intraoperative blood salvage is a ... The expression does not mean surgery that makes no use of blood or blood transfusion. Rather, it refers to surgery performed ...
... red blood cells, and platelets. Anemia and thrombocytopenia may require blood transfusion. Neutropenia (a decrease of the ... cells that produce white and red blood cells) are destroyed, meaning allogenic or autologous bone marrow cell transplants are ... As more than half of cancer patients are elderly, this adverse effect is only relevant for a minority of patients. A study in ... Passive targeting exploits the difference between tumor blood vessels and normal blood vessels. Blood vessels in tumors are " ...
... red blood cells, white blood cells, platelets and plasma), and transfusions of stored autologous blood or its primary ... US courts tend not to hold physicians responsible for adverse health effects that a patient incurred out of his or her own ... peri-operative extraction and transfusion of autologous blood). This religious position is due to their belief that blood is ... As a doctrine, Jehovah's Witnesses do not reject transfusion of whole autologous blood so long as it is not stored prior to ...
The other options is using the person's own blood. This is known as autologous blood transfusion. The person's red blood cells ... There is no evidence that a restrictive transfusion strategy affects death or major adverse events (e.g. cardiac events, ... Packed red blood cells, also known as packed cells, are red blood cells that have been separated for blood transfusion. The ... "Single Unit Transfusion Guide , National Blood Authority". Retrieved 2019-03-05. Blackstone, Eugene H.; Starr ...
Journal of Hematology and Blood Transfusion. 30 (Suppl 1): 202-204. doi:10.1007/s12288-013-0327-3. PMC 4192214. PMID 25332578. ... Thereafter the adverse effects of such intravenously administered cytokines lead to the extraction of the lymphocytes from the ... Autologous immune enhancement therapy (AIET) is a treatment method in which immune cells are taken out from the patient's body ... Radiotherapy is also a very effective mode of treatment in certain types of cancer, but it has its own adverse effects as well ...
By definition, autologous cells are obtained from one's own body, just as one may bank his or her own blood for elective ... Transfusion Medicine and Hemotherapy. 43 (4): 247-254. doi:10.1159/000447748. PMC 5040947. PMID 27721700. Ralston, Michelle ( ... A Comprehensive Analysis of Reported Adverse Events in Patients Receiving Unproven Stem Cell-Based Interventions". Stem Cells ... Blood, which requires extraction through apheresis, wherein blood is drawn from the donor (similar to a blood donation), and ...
... deletion syndrome but no other cytogenetic abnormalities and are dependent on red blood cell transfusions, for whom other ... Adverse events more common in people receiving lenalidomide for myeloma include neutropenia, deep vein thrombosis, infections, ... for people with multiple myeloma following autologous stem cell transplant. In 2009, The National Institute for Health and ... Severe side effects may include low blood platelets, low white blood cells, and blood clots. Use during pregnancy may harm the ...
April 1998: p. 30 "Autologous (self-donated) Blood as an Alternative to Allogeneic (donor-donated) Blood Transfusion". AABB. ... Transfusion. 48 (6): 1213-19. doi:10.1111/j.1537-2995.2008.01674.x. PMID 18346014. S2CID 403463. "Adverse Effect of Blood ... "Transfusion handbook, Summary information for Red Blood Cells". National Blood Transfusion Committee. Archived from the ... Blood bank#History (history of blood donation) Blood donation restrictions on men who have sex with men Blood substitute James ...
... this is referred to as autologous blood transfusion. Patients' own blood is collected and washed to produce concentrated red ... "Proposed standard definitions for surveillance of non infectious adverse transfusion reactions" (PDF). ... An allergic transfusion reaction is when a blood transfusion results in allergic reaction. It is among the most common ... Allergic reactions from blood transfusion may occur from the presence of allergy-causing antigens within the donor's blood, or ...
Dearden C (July 2012). "How I treat prolymphocytic leukemia". Blood. 120 (3): 538-51. doi:10.1182/blood-2012-01-380139. PMID ... Adoptive T cell therapy is a form of passive immunization by the transfusion of T-cells (adoptive cell transfer). They are ... Gardner TA, Elzey BD, Hahn NM (April 2012). "Sipuleucel-T (Provenge) autologous vaccine approved for treatment of men with ... suggesting that local administration of the anti-CTLA-4 therapy might result in fewer adverse events. Initial clinical trial ...
Autologous blood injection Autologous conditioned serum Hypoxia preconditioned plasma Platelet-rich fibrin matrix Platelet ... Blood Transfusion = Trasfusione del Sangue. 16 (6): 502-513. doi:10.2450/2018.0111-18. PMC 6214820. PMID 30201082. Zhang, YJ; ... The single systematic review of the literature did not report of the types and number of adverse events. In 2019, Health Canada ... is a concentrate of platelet-rich plasma protein derived from whole blood, centrifuged to remove red blood cells. Though ...
Blood vessels constrict in tissue that becomes cold and dilate in warm tissue, altering blood flow to the area. Thus keeping ... The challenge of any treatment is to address as many adverse factors as possible simultaneously, so each of them receives equal ... Velander PE, Theopold C, Gheerardyn R, Bleiziffer O, Yao F, Eriksson E (2004). "Autologous cultured keratinocytes suspensions ... April 2004). "Platelet gel for healing cutaneous chronic wounds". Transfusion and Apheresis Science. 30 (2): 145-51. doi: ...
Most blood for transfusion is collected as whole blood. Autologous donations are sometimes transfused without further ... to reduce the risk of transfusion related adverse events). However, it sometimes refers to a collection center, and some ... Several types of blood transfusion exist: Whole blood, which is blood transfused without separation. Red blood cells or packed ... A blood bank is a center where blood gathered as a result of blood donation is stored and preserved for later use in blood ...
... is also being studied as a substitute for normal blood transfusions in the developing world. More research is ... Adverse effects are similar to hematopoietic stem cell transplantation, namely graft-versus-host disease if the cord blood is ... The EGE concluded that "[t]he legitimacy of commercial cord blood banks for autologous use should be questioned as they sell a ... Cord blood is composed of all the elements found in whole blood - red blood cells, white blood cells, plasma, platelets. ...
... towards autologous transfusion, in which patients receive their own blood. Another impetus for autologous transfusion is the ... A greater effort to avoid adverse events due to transfusion has also increased the emphasis on blood conservation (see ... Intraoperative blood salvage (IOS), also known as cell salvage, is a specific type of autologous blood transfusion. ... is a form of autologous transfusion where whole blood is collected from a patient at the start of surgery into a standard blood ...
Further research into this technique should have potential benefits to gene therapy, blood transfusion, and topical medicine. ... Autologous stem cell based treatments for tendon injury, ligament injury, and osteoarthritis in dogs have been available to ... Saki N, Jalalifar MA, Soleimani M, Hajizamani S, Rahim F (2013). "Adverse Effect of High Glucose Concentration on Stem Cell ... The FDA has approved five hematopoietic stem-cell products derived from umbilical-cord blood, for the treatment of blood and ...
Cord Blood for Neonatal Hypoxic-Ischemic Encephalopathy Archived 2011-08-12 at Wikiwix, Autologous Cord Blood Cells for Hypoxic ... better establishment of red blood cell volume, and decreased need for blood transfusion". In January 2017, a revised Committee ... "Perfluorinated Compounds in Umbilical Cord Blood and Adverse Birth Outcomes". PLOS ONE. 7 (8): e42474. Bibcode:2012PLoSO... ... 2008). "Autologous Umbilical Cord Blood Infusion for Type 1 Diabetes". Exp. Hematol. 36 (6): 710-715. doi:10.1016/j.exphem. ...
... red blood cell transfusions or erythropoietin can be used for management of anemia. Chemotherapies and stem cell transplants ... In autologous hematopoietic stem-cell transplantation (ASCT) - the patient's own stem cells are collected from the patient's ... The evidence is very uncertain about the effect and serious adverse events Multiple national cancer treatment guidelines ... doi:10.1182/blood-2011-01-270140. PMC 3316455. PMID 21441462. Kyle RA, Rajkumar SV (2008). "Multiple myeloma". Blood. 111 (6): ...
Autologous transfusion uses patients' own blood which is stored previously. Compared to autologous blood transfusion, the ... These adverse effects facilitate the development of approaches to conserve the blood during cardiac surgery. These methods ... There are two primary methods, homologous blood transfusion and autologous blood transfusion, to reduce the massive blood loss ... During the cardiopulmonary bypass, blood is mixed directly through the homologous blood transfusion, but homologous blood may ...
APTT and PT to measure blood clotting, chest X-rays, ECG, and blood cross-matching for possible transfusion. About a month ... There is no strong evidence that this approach improves knee function, mortality, adverse events, or amount of pain compared to ... Autologous chondrocyte implantation Microfracture surgery Knee osteoarthritis Osseointegration Meniscus transplant Simon H ... less blood loss, lower risk of infection, stiffness, and blood clots, but a harder revision if necessary. Persons with ...
... peripheral blood, or umbilical cord blood. It may be autologous (the patient's own stem cells are used), allogeneic (the stem ... April 2009). "Adverse events among 2408 unrelated donors of peripheral blood stem cells: results of a prospective trial from ... This patient received regular blood transfusions, and an attempt was made to increase her leukocyte and platelet counts by ... Cord blood has a higher concentration of HSCs than is normally found in adult blood, but the small quantity of blood obtained ...
In 2014, type O red blood cells were synthesized at the Scottish National Blood Transfusion Service from iPSC. The cells were ... The benefits of using autologous iPSCs are that there is theoretically no risk of rejection and that it eliminates the need to ... "First serious adverse reaction to iPS-derived retinal cell transplant reported". The Japan Times Online. 17 January 2018. ... Although a pint of donated blood contains about two trillion red blood cells and over 107 million blood donations are collected ...
... is a group of blood malignancies that develop from lymphocytes (a type of white blood cell). The name often refers to ... The evidence is very uncertain about the effect on anxiety and serious adverse events. Lymphoma is the most common form of ... Moreover, it was seen that platelet transfusions for people undergoing a chemotherapy or a stem cell transplantation for the ... For people who relapse, high-dose chemotherapy followed by autologous stem cell transplantation is a proven approach. The ...
It is also possible to use the patient's own blood for transfusion. This is called autologous blood transfusion, which is ... Additionally, red blood cell surface antigens other than A, B and Rh D, might cause adverse reactions and sensitization, if ... for suitability in blood transfusion. A complete blood type would describe each of the 38 blood groups, and an individual's ... possibly a fetomaternal transfusion of blood from a fetus in pregnancy or occasionally a blood transfusion with D positive RBCs ...
"Patient Blood Management Guidelines , National Blood Authority". Archived from the original on 2016-01-15. ... "Transfusion-related adverse events in the Platelet Dose study". Transfusion. 55 (1): 144-53. doi:10.1111/trf.12791. PMC 4293226 ... However, this benefit was only seen in certain patient groups, and people undergoing an autologous stem cell transplant derived ... Unlike other blood products demand for platelet transfusions appears to be increasing in several countries around the world. An ...
Blood Transfusion. 28 (2): 89-96. doi:10.1007/s12288-011-0110-2. PMC 3332273. PMID 23730015. Partial expression: Adriaansen HJ ... December 2014). "Age-related clonal hematopoiesis associated with adverse outcomes". The New England Journal of Medicine. 371 ( ... December 1998). "Chemotherapy compared with autologous or allogeneic bone marrow transplantation in the management of acute ... Velpeau noted the blood of this person had a consistency "like gruel", and speculated the appearance of the blood was due to ...
Blood transfusions use as sources of blood either one's own (autologous transfusion), or someone else's (allogeneic or ... did blood transfusion achieve a scientific basis and became safer. Landsteiner discovered that adverse effects arise from ... Blood Transfusion Leaflets (NHS Blood and Transplant) Blood Transfusion Leaflets (Welsh Blood Service) Blood Transfusion ... Anemia Arnault Tzanck Blood transfusion in Sri Lanka Blood type (non-human) Xenotransfusion AIDS "Blood Transfusion , National ...
No infusion-related adverse events were observed. Metabolic indexes 1 year postinfusion were peak C-peptide median 0.50 ng/ml ( ... CONCLUSIONS Autologous umbilical cord blood transfusion in children with type 1 diabetes is safe but has yet to demonstrate ... Autologous Umbilical Cord Blood Transfusion in Young Children With Type 1 Diabetes Fails to Preserve C-Peptide ... Autologous Umbilical Cord Blood Transfusion in Very Young Children With Type 1 Diabetes. ...
... underwent a single autologous UCB transfusion. No adverse events were observed in association with autologous UCB infusion. All ... Autologous Umbilical Cord Blood Transfusion in Young Children With Type 1 Diabetes Fails to Preserve C-Peptide. ... Autologous Umbilical Cord Blood Transfusion in Young Children With Type 1 Diabetes Fails to Preserve C-Peptide ... Autologous Umbilical Cord Blood Transfusion in Young Children With Type 1 Diabetes Fails to Preserve C-Peptide ...
Majority of patients with the most severe thalassemia are transfusion-free years after gene therapy that uses the patients own ... Treatment-related adverse events were typical of autologous stem cell transplantation. No safety issue could be attributed to ... Gene therapy for blood disorder ends need for transfusions Most patients are transfusion-free after undergoing gene therapy ... Gene therapy for blood disorder ends need for transfusions. Ann & Robert H. Lurie Childrens Hospital of Chicago ...
Allogeneic blood transfusion-induced immunomodulation (TRIM) and its adverse effect on the prognosis of patients treated ... Group H received allogeneic blood transfusion; Group A received autologous whole blood transfusion. * P,0.05, ** P,0.01, ... Allogeneic blood transfusion exacerbates the impaired immune response. Autologous blood transfusion might be significantly ... receiving allogeneic blood transfusion) than those in group A (receiving autologous whole blood transfusion) (P,0.05). On the ...
... reduces the need for red blood cell (RBC) transfusions among cancer patients with chemotherapy-induced anemia, a report ... RBC transfusion, or length of hospital stay. No significant adverse events were noted in the autologous patients. ... In the studies of transplant patients, transfusion supplemented with epoetin was compared with transfusion alone. The analysis ... The frequency of adverse events associated with treatment does not appear to differ markedly between epoetin-treated patients ...
... or whole blood (WB) derived from ,= 900 milliliter (mL) of WB within 48 hours of the bleed (excluding autologous transfusion ... excluding autologous transfusion except for treatment of bleeding adverse event); f) Bleeding leading to bleeding index (BI) ,= ... Volume of Transfusion [ Time Frame: Up to Day 17 ]. The total volume of transfusion (RBCs or WB) received by the participant ... Number of Participants With Adverse Events (AEs), Serious Adverse Events (SAEs) and Deaths [ Time Frame: From first injection ...
Blood transfusion reactions, side effects, risks, and complications include allergic reactions, infections, and lung injuries. ... The type of blood transfusion depends on the situation. ... routine procedure used for blood loss from severe injuries or ... Blood can be provided from two sources: autologous blood (using your own blood) or donor blood (using someone elses blood). ... Volunteer donor blood usually is readily available, and when properly tested has a low incidence of adverse events. ...
There were no adverse effects from using the autologous system and it does reduce the need for a homologous blood transfusion. ... Decreasing the blood transfusion rate in elective hip replacement surgery using an autologous drainage system. ... Thirty-seven units of homologous blood were transfused in the normal drain group and 5 units in the autologous drain group. The ... with the use of autologous drains and the transfusion rate was reduced from 23% to 6% (P < 0.02). The mean length of hospital ...
Postoperative infections following autologous and homologous blood transfusion. Transfusion. 1992;32:27-30. ... Adverse effects of perioperative blood transfusion in patients with colorectal cancer. Eur J Surg. 1992;158:419-425. ... Blood transfusion-modulated tumor recurrence: first results of a randomized study of autologous versus allogeneic blood ... Therefore, autologous transfusion recipients probably received transfusions sooner, after less surgical blood loss, than did ...
... autologous blood transfusion explanation free. What is autologous blood transfusion? Meaning of autologous blood transfusion ... Looking for online definition of autologous blood transfusion in the Medical Dictionary? ... or when the recipient has an adverse reaction to some element of the donor blood. Most commonly, there is an immune-mediated ... autologous blood transfusion. Also found in: Dictionary, Thesaurus, Encyclopedia. autologous blood transfusion. 1. The ...
1991) Adverse reactions in patients transfused with cryopreserved marrow. Transfusion 31:521-6. ... A 30-year-old man, diagnosed with Hodgkins lymphoma, was admitted to our medical center for autologous peripheral blood stem ... Dimethylsulfoxide (DMSO) is a solvent commonly used for the cryopreservation of autologous peripheral blood stem cells (APBSC ... Dimethylsulfoxide (DMSO) is a solvent commonly used for the cryopreservation of autologous peripheral blood stem cells (APBSC ...
Blood Matters better safer transfusion program Essential elements of the Serious Transfusion Incident Reporting system (STIR) - ... This form will assist with your investigation of the adverse event at this stage this is a paper based system but with work in ... From volunteer or family donors or autologous collections. SHOT: The Serious Hazards of Transfusion Scheme *Launched in ... Blood smear examination -. making blood smear . preparation of blood smear. there are three types of blood smears: the cover ...
... is a blood salvage/cell salvage device that is an automated alternative to manual surgical drains and preoperative autologous ... Religious beliefs cause the patient to refuse allogeneic transfusion, but accept autologous transfusion. ... Please refer to the manual for indications for use, contraindications, warnings, precautions and potential adverse events. ... Compatible allogeneic blood is not available.. *The patient is unable to donate sufficient quantities of autologous blood prior ...
Documentation of adverse reactions and potential causes is necessary in order to obtain a more comprehensive risk profile of ... Here, we present a 63-year-old female who suffered an adverse reaction after undergoing an intra-articular PRP knee injection. ... Adverse reactions to PRP injections are extremely rare. In the literature, there are only two documented case reports relating ... Adverse reactions associated with autologous blood transfusion: evaluation and incidence at a large academic hospital. ...
Exclusive or supplemental use of autologous Blood can eliminate or reduce adverse effects of transfusion. Patients who receive ... Autologous Blood - Autologous Blood (donation) is Blood drawn from one individual to be given back to that individual, or a ... Blood cells which comprise the minor portion of whole Blood. Blood Count - The complete Blood count, or CBC. Blood Culture - ... In general, white Blood cells in a Blood transfusion serve no purpose, but are transfused along with the red Blood cells, ...
BACKGROUND: Transfusion of stored red blood cells (RBCs) can be associated with adverse side effects. Recent studies in mice ... Therefore, we here investigated if transfusion of 2 units of cryopreserved autologous RBCs induced a proinflammatory response ... Serum and blood samples taken at 2 hours before and at 2 and 48 hours after transfusion were analyzed for signs of ... Transfusion of cryopreserved human red blood cells into healthy humans is associated with rapid extravascular hemolysis without ...
... for EPO has forced cheating athletes to return to blood transfusion. Autologous blood transfusion with cryopreserved red blood ... BACKGROUND: Transfusion of stored red blood cells (RBCs) can be associated with adverse side effects. Recent studies in mice ... In total, 533 blood samples were included in the study (Clean = 220, Transfused = 313). In response to blood transfusion, the ... Serum and blood samples taken at 2 hours before and at 2 and 48 hours after transfusion were analyzed for signs of ...
Adverse reactions associated with autologous blood transfusion: evaluation and incidence at a large academic hospital. ... Risks and adverse outcomes associated with emergency-release red blood cell transfusion. Transfusion. 2013;53:1416-1420. ... Effect of transfusion of red blood cells with longer vs shorter storage duration on elevated blood lactate levels in children ... An update on mortality and morbidity in patients with very low postoperative hemoglobin levels who decline blood transfusion ( ...
Adverse reactions associated with autologous blood transfusion: evaluation and incidence at a large academic hospital. ... Risks and adverse outcomes associated with emergency-release red blood cell transfusion. Transfusion. 2013;53:1416-1420. ... Effect of transfusion of red blood cells with longer vs shorter storage duration on elevated blood lactate levels in children ... An update on mortality and morbidity in patients with very low postoperative hemoglobin levels who decline blood transfusion ( ...
Predonated autologous blood transfusions after total knee arthroplasty: immediate versus delayed administration. ... Adverse effects of RBC transfusion contrasted with other risks.. Risk is depicted on a logarithmic scale. Shaded bars represent ... Length of Storage of Red Blood Cells and Patient Survival After Blood Transfusion: A Binational Cohort Study Annals of Internal ... Red blood cell transfusion practice in elective orthopedic surgery: a multicenter cohort study. Transfusion. 2010;50(10):2117- ...
Red blood cell transfusion was associated with an adverse prognosis following primary THR, in particular with increased odds of ... Of the 28,087 THR patients, 9,063 (32.3%) received at least one red blood cell transfusion within 8 days of surgery. Transfused ... Blood transfusion was also associated with increased odds of pneumonia (OR 2.1; CI: 1.2-3.8), whereas the associations with ... from which we computed a propensity score for red blood cell transfusion based on detailed data on patient-, procedure-, and ...
But they also say that it is possible that transfusions of blood from whatever source "produce the same adverse reactions". ... They found that patients receiving any type of transfusion, whether of their own blood (autologous) or donated (allogeneic) ... Blood transfusions after cancer surgery may hamper patients survival prospects, according to research from the Netherlands.. ... "It seems beneficial to operate on patients with colorectal cancer in such a way that blood transfusions are either avoided or ...
Transfusion requirements (heterologous and autologous transfusions).. - Amount of blood loss (intraoperative blood loss). - ... Treatment-emergent adverse events. - Treatment-emergent serious adverse events. - Deaths. - Adverse events starting more than 7 ...
However, autologous transfusions were associated with a decreased risk (OR = 0.39, 95% CI: 0.16, 0.94). In summary, these ... to those of prior negative studies and do not support some previous reports of an adverse association between blood transfusion ... Keywords: blood transfusion; case-control studies; lymphoma, non-Hodgkin; risk factors; CI, confidence interval; HIV, human ... In the search for new risk factors, blood transfusions have been investigated and shown to be associated with subsequent ...
ANNEX 2. Notify Library - Adverse occurrence type taxonomy. *REFERENCES. *Background Documents*WORLD HEALTH ORGANISATION (WHO) ...
... the practice of autologous blood transfusions to be present among riders. And why not? While tests have been developed to test ... note that the latter two may be linked to some of the old stuff as hypertension is a known adverse effect of blood transfusion. ... for the use of synthetic EPO and homologous blood transfusions, there is still no definitive test for autologous doping; only ... we revealed that one of Denmarks leading blood researchers believed that Lance Armstrongs blood values from the 2009 Tour de ...
Traditional bleeding management has consisted of transfusion of autologous blood products, however, there is strong evidence ... Especially concerning is the increased reported incidence of noninfectious adverse events such as transfusion-related acute ... avoiding unnecessary transfusion of blood and blood product and limiting transfusion-related side-effects. SUMMARY This article ... avoiding unnecessary transfusion of blood and blood product and limiting transfusion-related side-effects. SUMMARY This article ...
... had donated blood for perioperative autologous transfusion, had adverse reactions to previous erythrocyte transfusions, or ... Hod EA, Spitalnik SL: Harmful effects of transfusion of older stored red blood cells: Iron and inflammation. Transfusion 2011; ... Variability and predictability of large-volume red blood cell transfusion in cardiac surgery: A multicenter study. Transfusion ... A Randomized Controlled Trial on Blood Salvage as Transfusion Alternative Using a Restrictive Transfusion Policy in Patients ...
During the last decades many efforts have been made to reduce transfusion requirements and adverse clinical effects during ... and resulted in significantly higher blood transfusion requirements (p , 0.05). Lactate, serum creatinine, troponin, and ... Retrograde Autologous Priming as a Safe and Easy Method to Reduce Hemodilution and Transfusion Requirements during Cardiac ... cardiopulmonary bypass (CPB). The minimal extracorporeal circulation (MECC) system and the technique of retrograde autologous ...
Transfusion-associated adverse events and implementation of blood safety measures - findings from the 2017 National Blood ... autologous and directed donations and transfusions, platelets, plasma and granulocyte transfusions, pediatric transfusions, ... BACKGROUND: Serious transfusion-associated adverse events are rare in the United States. To enhance blood safety, various ... autologous and directed donations and transfusions, severe donor-related adverse events, platelet and plasma collections and ...
  • The OrthoPAT system helps you avoid unnecessary allogeneic transfusions and returns fresh, high-quality blood throughout the perioperative care continuum in orthopedic surgery, yielding better patient outcomes, reduced reactions, and cost savings. (
  • Although there are no studies done on PRP to corroborate this hypothesis, adverse reactions to autologous blood transfusions have been documented in the literature and perhaps can provide further insight3. (
  • One retrospective review noted adverse reactions related to an antileukocyte antibody-mediated reaction and/or accumulation of pro-inflammatory cytokines4. (
  • Adverse reactions associated with autologous blood transfusion: evaluation and incidence at a large academic hospital. (
  • Pre-operative autologous blood donation and transfusion-related adverse reactions: A 14-year experience at a university hospital- ClinicalKey. (
  • Reactions due to components of Blood such as white Blood cells, platelets and serum protein are eliminated with autologous Blood. (
  • Nonimmunological transfusion reactions include cardiovascular overload, hypocalcemic tetany from citrate (used as the anticoagulant) overload, and disease transmission. (
  • The risks associated with allogenic transfusion, including disease transmission and adverse reactions, are essentially eliminated in the country due to strict blood supply screening and an otherwise homogenous population, hence there is a lack of interest in self-donating blood, Furnes said. (
  • In my series, following the indications of the system strictly, I have not observed any adverse reactions after the reinfusion. (
  • The major adverse reactions associated with the procedure are reduction in the platelet numbers and other haematopoietic elements. (
  • Participants will be able to manage patients receiving blood and blood components, including the identification of adverse reactions, and indications and contraindications for use. (
  • Adverse reactions include postural hypotension, piloerection, nausea, vomiting, and sometimes as short as 35 minutes in prayer or writing in a woman unwell without obvious murmur is valve than one ultrasound is helpful to ligate the hypogastric artery ligation internal iliac vessels can cause kernicterus in newborn, especially in males. (
  • Adverse reactions: The incidence of hepatitis b virus surface antigen (hbsag). (
  • Much more common risks of allogeneic transfusion include allergic transfusion reactions as well as febrile non-hemolytic transfusion reactions. (
  • Many reports have focused on allogenic transfusion risks, such as immunomodulation, transfusion related immune-mediated reactions and infection. (
  • Canadian Blood Services to, Blood Transfusions, Blood Alternatives and Transfusion Reactions A Guide to Transfusion Medicine blood alternatives and transfusion. (
  • Patients who have previously been transfused, multiparous women and patients receiving emergency uncross-matched transfusion are at increased risk of immediate and delayed haemolytic transfusion reactions. (
  • Platelet and granulocyte transfusions are associated with the highest rates of febrile non-haemolytic transfusion reactions. (
  • The incidence of such reactions can be modified by changes to the blood component in the way it is processed and by leucodepletion . (
  • Transfusion of fresh frozen plasma is associated with a higher risk of allergic reactions. (
  • Some reactions are mild, but severe life-threatening reactions such as anaphylaxis and Transfusion-related acute lung injury (TRALI) may occur. (
  • Stop transfusion immediately and follow other steps for managing suspected transfusion reactions . (
  • Chapter 5, Transfusion Reactions. (
  • Bloody Easy 3: Blood Transfusions, Blood Alternatives and Transfusion Reactions: A Guide to Transfusion Medicine, 3rd edition. (
  • Direct costs of transfusion reactions - an expert judgement approach. (
  • Despite increasingly meticulous haemovigilance reporting throughout the world, a systematic assessment of the cost of transfusion reactions is still lacking. (
  • Data on the cost of transfusion reactions could support decision-making regarding blood transfusion safety measures. (
  • Thirteen experts from nine hospitals were asked to estimate the additional care required following various types of transfusion reactions. (
  • When the trial ended after 18 months, no adverse reactions were attributed to the IMP itself. (
  • Since Australia introduced pre-release bacterial screening in early 2008, septic transfusion reactions have greatly declined. (
  • Allogenic blood transfusion (ABT) is associated with complications such as blood-borne infections, immunological reactions and high treatment costs (7-9). (
  • The patient or physician prefers perioperative autotransfusion rather than preoperative autologous donation or transfusion of allogeneic blood. (
  • Autologous Blood - Autologous Blood (donation) is Blood drawn from one individual to be given back to that individual, or a close very Blood match designee, as the need for transfusion arises. (
  • We have found in rats that the donation of blood can decrease natural killer cell activity and stimulate tumour growth. (
  • A number of effective interventions have been developed, such as preoperative autologous donation, cell salvage, or the use of erythropoietin. (
  • These methods contain preoperative autologous blood donation (PABD), acute normovolemic hemodilution (ANH) and cell salvage. (
  • Autologous blood donation and reinfusion is almost non-existent in Norway due to a good allogenic blood bank system. (
  • Athanasios Zacharopoulos, MD, in the Department of Orthopaedics at Greece s General Hospital of Amfissa, said autologous blood donation has been a part of his TKA routine for the past 10 years. (
  • It is cost-effective compared to preoperative erythropoietin and autologous blood donation 6-7 . (
  • For religious reasons, Jehovah's Witnesses may choose not to accept any allogeneic transfusions from a volunteer's blood donation but may accept the use of autologous blood salvaged during surgery to restore their blood volume and homeostasis during the course of an operation, although not autologous blood donated beforehand. (
  • You will be asked to sign a consent form to show that the risks, benefits and alternatives for an autologous donation and transfusion have been explained to you, that you have been able to ask any questions and you agree to receive the treatment. (
  • The findings of this trial are important, since the investigators used a number of restrictive transfusion strategies (e.g., autologous donation, low hematocrit trigger for transfusion, blood-salvaging procedures with the exception of no cell saver) that were not always employed in earlier trials involving hemostatic agents. (
  • The body will easily replace the blood cells and volume of the fluid between each donation. (
  • When the patient donates 2 or more units of blood within 3- 10 days before planned surgery in a normal single blood bag is called pre- deposit autologous donation. (
  • Frequent transfusions, however, can cause serious complications due to iron toxicity and viral infections. (
  • It is one of the most serious transfusion complications. (
  • The objective of this large population-based follow-up study was to determine whether allogeneic red blood cell transfusion was associated with increased odds of complications following THR. (
  • In this observational study, intraoperative blood cell transfusion predicted the outcome after cardiac surgery, resulting in more postoperative complications. (
  • The major complications of high-dose chemotherapy supported by autologous bone marrow transplant (BMT) are disease recurrence, infection, the need for red blood cell and platelet transfusions, delayed or incomplete engraftment, organ damage from the ablative regimen, prolonged hospitalization, and high cost treatment. (
  • Mazzei CA, Popovsky MA, Kopko PM. Non-infectious complications of blood transfusion. (
  • Rare systemic complications after PDR (Transfusion transmitted Babesiosis, pituitary apoplexy, and TRALI) and a number of uncommon and unusual other complications are discussed. (
  • Beta-thalassemia is a blood disorder caused by a mutation in the HBB gene that reduces production of the protein hemoglobin, which affects the blood's ability to transport oxygen and is associated with life-threatening complications such as severe anemia and organ damage. (
  • However, transfusion-related complications such as iron overload can be deadly. (
  • These important results show that gene therapy is a promising new option for reducing or eliminating blood transfusions and limiting long-term complications of transfusions in patients with this disease," says Dr. Mark C. Walters, Director of the Blood & Marrow Transplantation (BMT) program at UCSF Benioff Children's Hospital Oakland and lead investigator of the Northstar study. (
  • The priming solutions, which have been previously prepared using high volume of isotonic solutions or colloids may lead to complications such as postoperative fluid overloading and dilutional anemia which deems postoperative blood transfusion mandatory in some cases. (
  • Several studies have highlighted the disadvantages of allogenic blood, including a negative effect on postoperative complications, length of hospital stay, cost and mortality [7,8,9]. (
  • According to the published literature, some of the complications associated with TKA blood loss are postoperative pain, hematoma and seroma formation, arthrofibrosis and persistent bleeding (10,11). (
  • Proper investigation of different techniques used to control blood loss in TKA and the associated complications could lead us to the discovery of the most effective treatment procedures in this regard. (
  • What are the most common symptoms and complications associated with blood loss in TKA? (
  • A prospective analysis for prevalence of complications in Thai non-transfusion-dependent Hb E/β-thalassemia and α-thalassemia (Hb H disease). (
  • Recently, complications in patients with nontransfusion-dependent thalassemia (NTDT), in particular those with β- thalassemia intermedia (β-TI), were found to be significantly different from those in patients with transfusion dependent thalassemia (TDT), mainly β- thalassemia major (β-TM). (
  • The pharmacological methods used to achieve systemic hemostasis have generated much discussion due to concerns of serious adverse effects (e.g., thromboembolic complications) and costs of therapy in addition to efficacy considerations. (
  • With a simple, quick and advantageous process, your clinicians at Amoderm are able to harness a very high concentration of your biological nutrient-rich cells and create autologous platelet-rich plasma (i.e. your blood plasma that has been enriched with your blood platelets and proteins). (
  • Whole blood, packed red blood cells and other blood products replenish volume, oxygen-carrying capacity, platelet volume, and clotting factors. (
  • The advent of plastic bags enabled separation of a unit of blood into component parts-the ready availability of platelet concentrates allowed intensification of chemotherapy regimens and contributed towards improved survival and reduced morbidity. (
  • In our study of healthy dogs receiving autologous RBC transfusions stored for 7 (fresh) and 28 (old) days, administration of old, but not fresh, RBC units was associated with a pro-inflammatory cytokine response, exemplified by monocyte chemoattractant protein (MCP)-1, and accompanied by increased neutrophil counts and decreased platelet counts. (
  • All red cell and platelet components produced by the blood service are leucodepleted. (
  • Blood viscosity significantly increased, whereas platelet and WBC counts significantly decreased after transfusion. (
  • Such examples are autologous transfusion techniques, computer-assisted surgery (CAS), antifibrinolytic drugs, tourniquet, fibrin sealant and autologous platelet gel (APG) (12-16). (
  • 1 year of age, with type 1 diabetes (T1D), and for whom autologous UCB was stored, were recruited for participation (clinical trial reg. (
  • Gene therapy for transfusion-dependent thalassemia, an inherited blood disorder, produced positive outcomes in an interim analysis of two international Phase 1/2 clinical trials, according to the results published in New England Journal of Medicine . (
  • Deleterious clinical effects of transfusion-associated immunomodulation: fact or fiction? (
  • 10 This clinical syndrome, the mechanisms of which remain to be defined, has been referred to in the transfusion medicine literature as allogeneic blood transfusion-associated immunomodulation (TRIM). (
  • Subsequent clinical studies and studies in experimental animals corroborated the results of Opelz et al, 1 and allogeneic blood transfusions were used deliberately in the early 1980s to prevent rejection of renal allografts. (
  • Since 1981, more than 150 clinical studies have examined the association of perioperative allogeneic blood transfusion with cancer recurrence and/or postoperative bacterial infection. (
  • a group of clinical signs due to antibody in the recipient's blood reacting with the transfused red blood cells when blood for transfusion is incorrectly matched, or when the recipient has an adverse reaction to some element of the donor blood. (
  • However, blood cell transfusions are associated with morbidity and mortality in clinical studies with critically ill patients. (
  • The purpose of this study was to evaluate the relationship between blood transfusion in the operative room and clinical outcomes after cardiac surgery. (
  • During the last decades many efforts have been made to reduce transfusion requirements and adverse clinical effects during cardiopulmonary bypass (CPB). (
  • Autologous fibrin glue (a new method of preparation)" Surgical Forum (41st Annual Forum on Fundamental Surgical Problems Held at the 71st Annual Clinical Congress of the American College of Surgeons, Chicago) 36:544-547 (1985). (
  • Cambridge, Massachusetts-based bluebird bio ( BLUE ) soared to an all-time intraday high in Monday action after releasing positive preliminary clinical trial data for its experimental gene therapy to treat the rare blood disorder beta-thalassermia major. (
  • The consequences of transfusion transmitted infections, many of which have a long latent period before clinical expression, to neonates and young children with a normal life expectancy will be much more significant than to the elderly. (
  • This study aimed to evaluate the clinical, haematological and biochemical responses to autologous blood transfusion and the feasibility of this practice in sheep. (
  • The clinical, haematological and biochemical parameters were evaluated before blood collection and reinfusion, after 10 minutes of collection and reinfusion, after 3, 6, 12, 24, 48, 96 and 192 hours after collection and reinfusion. (
  • Autologous transfusion in sheep slightly altered the physiological, biochemical and haematological responses of sheep, indicating that the technique proposed is safe and can be applied in the clinical practice of this species. (
  • Considering the lack of studies related to the use of autologous blood transfusions in sheep, as well as the possible clinical, haematological and biochemical changes caused by this therapeutic practice, coupled with the possible contribution of the technique in veterinary medicine surgical interventions, this study aimed to evaluate the clinical, haematological and biochemical responses of sheep undergoing autologous blood transfusions. (
  • Prospective, randomized clinical trial enrolling 60 client-owned dogs with primary IMHA and 60 dogs with IMT deemed to be in need of a RBC transfusion. (
  • A major problem after clinical autologous islet transplantation (AIT) is the difficulty in achieving insulin independence. (
  • transfusion guidelines, stories from CBS transfusion and highlight presenters from our Canadian transfusion community Choosing Wisely Implementation Guide:, The LearnTransfusion series is the seminar component of and clinical aspects of transfusion via weekly webinars organized by Canadian Blood Services. (
  • Clinical Guide to Transfusion - Questions or Feedback. (
  • We’re here to answer your questions about the Clinical Guide to Transfusion. (
  • please check the items that are common clinical signs and symptoms of adverse transfusion events. (
  • Clinical guide to transfusion: products and practices. (
  • Blood transfusion has well proven clinical benefit in the treatment of anemia where it helps by improving oxygen delivery to tissues [1]. (
  • • Obtaining complete clinical and laboratory TACO vs. TRALI B-type Natriuretic Peptide вЂ" Pre-transfusion to post-transfusion ratio has relatively good sens, Canadian Blood Services has a great resource, its Clinical Guide to Transfusion. (
  • Canadian Blood Services has a great resource, its Clinical Guide to Transfusion. (
  • Musings on transfusion medicine For more information on Choosing Wisely developed with funding from Canadian Blood Services in Clinical Guide to Transfusion. (
  • Electronic Blood Tracking product and ending the transfusion on the ward or in the clinical a quick guide on using the BloodTrack Enquiry system Clinical guide to transfusion: products and practices. (
  • Clear written procedures and adequate staff training are essential for all aspects of the clinical transfusion process-from initial collection of samples for pretransfusion testing through to final documentation of the transfusion process and outcome. (
  • Acute haemolytic reaction or transfusion associated sepsis may have similar initial clinical findings. (
  • Only blood or plasma from male donors is used in the manufacture of clinical plasma products such as FFP or cryoprecipitate. (
  • Although they are very useful agents, they are associated with a number of adverse events and some with considerable clinical significance. (
  • CONCLUSIONS AND CLINICAL RELEVANCE: Results indicated that pRBC transfusion had only small effects on the TEG tracings of hemodynamically stable dogs. (
  • Oakland, CA - Interim results of clinical trials by investigators at UCSF Benioff Children's Hospital Oakland and Ann and Robert H. Lurie Children's Hospital of Chicago reveal that a majority of the 22 patients in two Phase 1/2 studies followed for two years or longer remained free from transfusions. (
  • The results are from two separate, two-year clinical studies using LentiGlobin® gene therapy to stop or reduce chronic blood transfusions in patients with transfusion-dependent β-thalassemia (TDT). (
  • The intraoperative and postoperative conditions, blood transfusion volume, clinical and hematological outcomes, and total blood transfusion cost were examined. (
  • These factors support the need to promote safe and evidence-based clinical transfusion practice. (
  • 4 and new transfusion research, such as trials assessing the clinical effects and logistical implications of the duration of blood storage. (
  • leukocyte transfusion has been effective in augmenting recipient immunity only in limited clinical situations. (
  • With growing clinical experience, however, it is increasingly clear that some adverse immune effects may be exploited for therapeutic benefit. (
  • Placental blood for bone marrow replacement: the New York Blood Center's program and clinical results. (
  • The Placental Blood Program of the New York Blood Center has developed techniques for collecting, testing, freezing and searching units on behalf of unrelated patients in need of hematopoietic stem cell replacement since 1993 and provided analysis of the outcomes of these transplants identified variables associated with clinical outcomes. (
  • In clinical medicine conventional blood and its components are used in supportive therapies dependent on the choice of apparent uncritical trigger factors. (
  • Blood loss prevention in total knee arthroplasty (TKA): a systematic review', Reviews in Clinical Medicine , 4(3), pp. 102-123. (
  • 23, 2017-- bluebird bio, Inc. ( Nasdaq: BLUE ), a clinical-stage company committed to developing potentially transformative gene therapies for serious genetic diseases and T cell-based immunotherapies for cancer, announced new data from the ongoing HGB-205 clinical study evaluating its LentiGlobin gene therapy product candidate in patients with transfusion-dependent β-thalassemia (TDT) and severe sickle cell disease (SCD). (
  • Recently evidenced by these preclinical results, clinical trials using autologous myoblast sheets have been started in ICM and DCM patients and some patients showed LV reverse remodelling, improved symptoms, and exercise tolerance. (
  • Peripheral blood and an aliquot of UCB from potential subjects were shipped to the University of Florida for infectious disease testing, HLA confirmation, and viability screening. (
  • Dimethylsulfoxide (DMSO) is a solvent commonly used for the cryopreservation of autologous peripheral blood stem cells (APBSC). (
  • A 30-year-old man, diagnosed with Hodgkin's lymphoma, was admitted to our medical center for autologous peripheral blood stem cell transplantation. (
  • Comparison of transplant outcomes from matched sibling bone marrow or peripheral blood stem cell and unrelated cord blood in patients 50 years or older pp. (
  • The requirement of blood transfusion during open-heart surgical operations is almost inevitable because the metabolism must be continuously kept working through the peripheral blood flow. (
  • Surprisingly, the number of circulating hematopoietic progenitor cells was higher when measured in the peripheral blood of infants following immediate versus delayed cord clamping although the differences were not statistically significant. (
  • The mobilization of peripheral blood progenitor cells (PBPC) substitutes the autologous BMT. (
  • These include: Minimally invasive surgical techniques Erythropoietin (a hormone that stimulates peripheral stem cells in the bone marrow to produce red blood cells) Blood salvage procedures Blood substitutes such as blood volume expanders and oxygen carriers (the latter as yet unlicensed in North America) Regardless of manufacturer, there are many types of cell processors. (
  • Peripheral blood mononuclear cells were isolated from 6 elderly MDS patients and were stimulated by cytokines in vitro to form CIK cells. (
  • For many decades, bone marrow (BM) transplantation was the only viable method for transplanting hematopoietic stem cells, although their presence had been demonstrated in peripheral blood. (
  • Under steady-state conditions, a small amount of hematopoietic stem cells constantly leave the BM and penetrate tissues, returning to the BM or peripheral niches via the blood or lymphatic system [ 2 ]. (
  • The use of mobilized peripheral blood is now the method of choice in autologous transplantation for various reasons, including an elevated production of immature cells, and, in comparison to the utilization of BM, the shorter time period required for a satisfactory repopulation, the more rapid engraftment, fewer technical difficulties, lower risk, and considerably less pain [ 6 ]. (
  • Although BM and peripheral blood are both still considered a source of stem/progenitor cells for this purpose [ 8 , 9 ], peripheral blood is used in 71% of allogeneic transplantations [ 6 ]. (
  • The hemoglobin was 6.7 g/dL and dropped to 5 g/dL on day two, and marked spherocytosis was noted on peripheral smear while red blood cell indices were normal. (
  • Administer busulfan injection in combination with cyclophosphamide as a conditioning regimen prior to bone marrow or peripheral blood progenitor cell replacement. (
  • Activation of the immune system was assessed by measuring peripheral blood CD4 + , CD8 + , and CD69 + lymphocytes. (
  • Sustained elevation in the percentage of peripheral blood CD4 + lymphocytes was observed up to 21 days following CT-011 treatment. (
  • Importantly, immunomodulatory capacity was intact, as Crohn's disease MSCs significantly reduced peripheral blood mononuclear cell proliferation in vitro. (
  • Volunteer donor blood usually is readily available, and when properly tested has a low incidence of adverse events. (
  • Evidence from a variety of sources indicates that allogeneic blood transfusion enhances the survival of renal allografts 1 and may increase the recurrence rate of resected malignancies 2 and the incidence of postoperative bacterial infections, 3-7 as well as reduce the recurrence rate of Crohn disease 8 and/or activate infections with cytomegalovirus 9 or human immunodeficiency virus. (
  • Especially concerning is the increased reported incidence of noninfectious adverse events such as transfusion-related acute lung injury, transfusion-related circulatory overload and transfusion-related immunomodulation. (
  • The invasive nature of coronary artery bypass grafting (CABG), the associated decrease of body temperature and the use of cardiopulmonary bypass (CPB) are major reasons for increased blood loss and high incidence for blood transfusions during and after this procedures. (
  • The true incidence is unknown but variably reported between 1:1200 to 1:190 000 transfusions(1) with estimates around 1:10 000 most commonly reported. (
  • In order to reduce the incidence of adverse events resulting from AB transfusion and to cope with increasing blood shortage and medical costs, IBS has been recently applied in the field of cardiac surgery. (
  • There is evidence that allogenic transfusions are associated with immunomodulation, and an increased incidence of infection [5]. (
  • It is composed of Blood cells, platelets, and plasma. (
  • Apheresis - A procedure where whole Blood is removed from the body and desired component(s), such as plasma or platelets is retained and the remainder of the Blood is returned to the donor. (
  • Among the elements transfused, in addition to whole blood, are packed red blood cells, plasma, platelets, granulocytes and cryoprecipitate, a plasma protein rich in antihemophilic factor VIII. (
  • Leukemia depletes the numbers of red blood cells, platelets, or other blood components. (
  • The cells travel to bone marrow sites throughout the body and slowly repopulate numbers of red or white blood cells, or platelets. (
  • Your clinician will place the blood into a centrifuge machine and spin the blood at a very rapid rate to separate various components of blood, namely the plasma and the platelets from other components of the blood. (
  • A procedure that supplies the body with a specific types of blood cells (red blood cells or platelets) that are low in number. (
  • TRALI has been implicated in transfusion of unfractionated plasma-containing components (red cells, platelets and plasma). (
  • To reduce the risk of antibody-mediated TRALI, donors with a possibility of having HLA or HNA antibodies either because of a history of pregnancy or transfusion are not used for plasma products or apheresis platelets. (
  • To further reduce the TRALI risk associated with apheresis platelets the Blood Service has moved to a plateletpheresis panel comprised of male donors and female donors who have never been pregnant (nulligravida). (
  • This change was introduced during the 2014/15 financial year and since July 2016 100% of apheresis platelets issued by the Blood Service have been from male or nulligravida female donors. (
  • Measures introduced in Australia and elsewhere to minimise bacterial contamination include diversion pouches used during donor blood collection, and routine pre-release bacterial screening of platelets. (
  • Red blood cells, white blood cells and platelets are constantly being made in your bone marrow. (
  • Whenever the patient requires blood transfusion, already collected autologous fresh blood is transfused back to patient with fresh platelets and coagulation factors. (
  • CONCLUSIONS Autologous umbilical cord blood transfusion in children with type 1 diabetes is safe but has yet to demonstrate efficacy in preserving C-peptide. (
  • Directed donor blood allows the patient to receive blood from known donors. (
  • A blood transfusion is the transfer of blood or blood products from one person (donor) into another person's bloodstream (recipient). (
  • autologous blood (using your own blood) or donor blood (using someone else's blood). (
  • Allogeneic or Allogeneic Blood - Blood from someone else that matches yours, usually from a volunteer Blood donor. (
  • The blood comes from a donor. (
  • Though donor and recipient blood is tested for type, you will be monitored for any signs of an adverse reaction during the transfusion. (
  • for example, the National Blood Service is currently revising its donor questionnaire in relation to recent travel to take account of the possible risks of West Nile Virus and severe acute respiratory syndrome (SARS). (
  • It has been used for many years and gained greater attention over time as risks associated with allogenic (separate-donor) blood transfusion have seen greater publicity and become more fully appreciated. (
  • Notify your Transfusion Service Provider to contact the Blood Service so we can quarantine and test related components from the same donor and prevent TRALI in other recipients. (
  • We report two separate episodes of transfusion-related acute lung injury (TRALI) in two thalassaemia patients who received red blood cell transfusions from the same multiparous donor. (
  • Login using your online or NZ Blood Service Donor App login details. (
  • Once registered, your login details will be the same for both the website and the NZ Blood Service Donor app. (
  • Historically, studies that established frozen repositories of transfusion recipient and/or blood donor samples were important in establishing the risk of many TTI agents, including the human immunodeficiency virus (HIV), hepatitis B virus (HBV) and hepatitis C virus (HCV). (
  • Allogeneic blood transfusion-induced immunomodulation (TRIM) and its adverse effect on the prognosis of patients treated surgically for cancer remain complex and controversial. (
  • Additional risks include transfusion related acute lung injury (TRALI), transfusion associated circulatory overload (TACO) and transfusion-associated immunomodulation. (
  • Transfusion-associated immunomodulation, which may suppress the immune response and cause adverse effects such as a small increase in the risk of postoperative infection. (
  • the practice of autologous blood transfusions to be present among riders. (
  • Adverse effects of low hematocrit during cardiopulmonary bypass in the adult: should current practice be changed? (
  • At the same time, new guidelines have recently been published to optimise transfusion practice for children. (
  • A closer examination of our practice indicates that little of our paediatric transfusion practice is well grounded in satisfactory evidence by today's standards. (
  • Furthermore, a cross functional group of medical and support staff is charged with the responsibility to take the leadership role in improving transfusion practice when indicated. (
  • Successful performance of these functions requires that the medical staff agree to some set of practice guidelines for ordering blood transfusion. (
  • If we document that transfusion of "older" RBCs to dogs with IMHA and IMT is associated with an increased inflammatory response, this study would provide the basis for a larger multi-center study to evaluate the effect of duration of RBC storage on morbidity and mortality in anemic canine patients, potentially changing our current transfusion practice. (
  • B lood transfusion is often lifesaving but not without risk, and many aspects of transfusion practice lack a sound evidence base when compared with other areas of medicine. (
  • Although these and other initiatives contribute to safer transfusion, avoidance of unnecessary transfusion is essential to ensuring safe transfusion practice. (
  • Such trials in critical care areas would be of enormous value, not only in recording adverse effects and under-transfusion, but also indicating the value of decision analysis and cost-effectiveness in transfusion practice. (
  • Going into the 2009 Tour de France, many predicted the practice of autologous blood transfusions to be present among riders. (
  • We saw remarkable outcomes using LentiGlobin gene therapy, with most patients no longer needing monthly transfusions," said leading author Alexis Thompson, MD, Head of Hematology and Director of the Comprehensive Thalassemia Program at Ann & Robert H. Lurie Children's Hospital of Chicago, as well as Professor of Pediatrics at Northwestern University Feinberg School of Medicine. (
  • The study reviewed the outcomes in published studies comparing epoetin with transfusion alone in patients with therapy- or cancer-related anemia. (
  • The most robust evidence that epoetin improves transfusion outcomes in these patients comes from trials in patient groups with baseline Hb of 10 g/dL or less,' the report found. (
  • Allogenic blood transfusions are often given and considered necessary in such operations, in spite of increased mortality, morbidity and major adverse outcomes resulting from transfusion. (
  • In other patient populations, erythrocyte transfusion has been associated with increased risk of adverse outcomes including sepsis, multisystem organ dysfunction, and death. (
  • A proactive approach to blood management will have a positive effect on early- and long-term outcomes and greater success in the management of total joint arthroplasty patients. (
  • Thereby the risks of transfusion are removed and hemoglobin status is maximized, leading a positive effect on the patient's recovery and early- and long-term outcomes. (
  • Orthopedic surgery may be associated with substantial blood loss requiring transfusion of erythrocytes.Transfusion of allogeneic erythrocytes is not free of adverse events and has been associated with transmission of infectious diseases, increased postoperative bacterial infection, immune sensitization, and transfusion related acute lung injury. (
  • Individuals with the human neutrophil antigen (HNA)-3b/3b type can produce HNA-3a antibodies, which have been reported to cause severe, sometimes fatal transfusion-related acute lung injury (TRALI). (
  • CONCLUSIONS: Transfusion of erythrocytes to patients with acute lung injury had no effect on the development of acute kidney injury. (
  • compare the positive post-transfusion DAT to pre-transfusion DAT Post antibody screen to identify antibody, elution of DAT (+) cells Re-do pre antibody screening. (
  • Patient post-transfusion samples: 10mL serum and 20mL EDTA or ACD. (
  • In order for bone marrow transplant to be successful, certain markers (called HLA types) on the donor's and recipient's blood cells and bone marrow cells must match. (
  • Lesser amounts of intraoperative and postoperative blood and blood product transfusions as well as postoperative drainage were observed in the study (ROP) group. (
  • The purpose was to further evaluate the effect of autologous versus allogeneic blood transfusion on immunological status in patients undergoing surgery for gastric cancer. (
  • Some circumstances will clearly dictate when banking the cord blood stem cells for future therapeutic needs (e.g., family history of malignant, genetic or immunological disorders) is preferable to infusing additional red blood cells to the infant at birth (e.g., for suspected iron-deficient anemia). (
  • 24 hours), immunological transfusion reaction. (
  • From leukocyte reduction to leukocyte transfusion: the immunological effects of transfused leukocytes. (
  • Studies in leukocyte reduction and leukocyte transfusion have progressed separately as if the leukocytes' adverse and therapeutic effects result from different immunological mechanisms. (
  • RESEARCH DESIGN AND METHODS Fifteen patients diagnosed with type 1 diabetes and for whom autologous umbilical cord blood was stored underwent a single intravenous infusion of autologous cells and completed 1 year of postinfusion follow-up. (
  • RESEARCH DESIGN AND METHODS A total of 24 T1D patients (median age 5.1 years) received a single intravenous infusion of autologous UCB cells and underwent metabolic and immunologic assessments. (
  • Acute hemolytic transfusion reaction (HTR or AHTR) - Acute hemolytic transfusion reaction can cause serious, potentially fatal consequences. (
  • 9. TRANSFUSION REACTION LABORATORY INVESTIGATION  After the initial measure , the 3 basic preliminary test Clerical check Visual check Serology check Purpose : to determine the likelihood the occurrence of hemolytic transfusion reaction. (
  • An acute hemolytic transfusion reaction due to ABO incompatibility is specifically identified as a reviewable sentinel event for which a comprehensive analysis of cause, corrective action, preventive action and reporting are required. (
  • The patient was diagnosed with drug-induced autoimmune hemolytic anemia (DIIHA) secondary to fluoroquinolone use and was treated supportively with intravenous hydration and red blood cells transfusions. (
  • Autoimmune hemolytic anemia is an immune disorder caused by antibodies directed against autologous red cells. (
  • Here, our patient had no identifiable prior triggers, yet experienced an adverse reaction to PRP. (
  • One hypothesis to consider is if erythrocyte shearing or blood extravasation from a difficult blood draw could lead to this adverse reaction. (
  • 1. The collection of a patient's own blood before surgery, to be used if the patient needs a transfusion during or after the surgery, to reduce the possibility of needing banked blood, and with it the risk of having a transfusion reaction or contracting a transmissible infection. (
  • Furthermore, since all constitutes retrieved in PRP are exclusively from your own body (autologous in origin), there is virtually no risk of an allergic reaction or intolerance. (
  • When to suspect this adverse reaction? (
  • The antigen-antibody reaction activates neutrophils in the lung microcirculation, releasing oxidases and proteases that damage blood vessels and make them leak. (
  • This is partly caused by the fact that such an assessment requires a subjective expert assessment of the additional costs linked to the adverse reaction. (
  • A subsequent hypothesis proposed that, if allogeneic blood transfusion causes immunosuppression, then recipients of perioperative allogeneic blood transfusion could be at increased risk for postoperative bacterial infection. (
  • Our OrthoPAT ® orthopedic perioperative autotransfusion system is a fully automated device that collects, washes, and returns your patients' blood during and after orthopedic surgery helping to give them the best chance at avoiding unnecessary allogeneic transfusions and related risks of infection. (
  • By consistently delivering fresh red blood cells with high hematocrit, the OrthoPAT system helps to ensure that your patients receive their own high-quality blood with a reduced risk of infection. (
  • This helps with treating anemia symptoms, and improving infection control and blood clotting. (
  • Once the procedure is done, the recipient is isolated to reduce the chance of infection while the healthy stem cells repopulate the blood cell count. (
  • Compared to autologous blood transfusion, the homologous blood transfusion has more side effects, such as postoperative Infection, immunosuppression and viral transmission. (
  • There continues to be concerns about transfusion transmitted infection, most recently in relation to variant Creutzfeldt-Jakob disease (vCJD). (
  • Transfusion transmitted infection is probably the best publicised of the hazards of transfusion, certainly in the minds of parents who may ask about HIV transmission. (
  • West Nile Virus has recently emerged as a significant problem in the USA with 23 cases of infection confirmed transmitted by transfusion. (
  • As a result, the blood collection industry in the USA initiated a voluntary withdrawal of stored units of FFP and cryoprecipitate that might contain the infection-as there was no test available at that time. (
  • Providing safe blood for transfusion remains a challenge despite advances in preventing transmission of hepatitis B virus (HBV), hepatitis C virus (HCV), AIDS/HIV, HTLV-I/II, West Nile virus (WNV), syphilis, Chagas disease, Zika virus, and transfusion-transmitted bacterial infection. (
  • Transfusion of RBCs stored ≥ 14 days may be associated with increased rates of infection, thrombosis, morbidity, and mortality in hospitalized human patients, especially those with trauma, after surgery, or in an ICU. (
  • While historically the focus has been on prevention of transfusion-transmitted infection, other major hazards have been highlighted through haemovigilance programs. (
  • The risks of transfusion-transmitted infection: direct estimation and mathematical modelling. (
  • Direct measurement of the risk of transfusion-transmitted infection (TTI) is practical and accurate only if the level of risk is high. (
  • The residual risk of transfusion-transmitted viral infection in developed countries is considered minimal or negligible. (
  • Bierbaum reported transfusion rates of 57% for total hip arthroplasty (THA) and 39% for total knee arthroplasty (TKA), with an increased risk of fluid overload, infection rate, and duration of hospitalization in the patients who received allogenic transfusion [6]. (
  • Treatment by injection of autologous blood into the epidural space has gained wide acceptance since its introduction in 1960, though it is contraindicated by blood dyscrasias, anticoagulant therapy, bleeding, and localized infection. (
  • It is also generally considered a blood conservation method used in most patients during the cardiopulmonary bypass (CPB). (
  • Cardiopulmonary bypass (CPB) is a medical technique to oxygenate the blood and remove the carbon dioxide during the cardiac operation. (
  • Direct transfusion is a blood salvaging method associated with cardiopulmonary bypass (CPB) circuits or other extracorporeal circuits (ECC) that are used in surgery such as coronary artery bypass grafts (CABG), valve replacement, or surgical repair of the great vessels. (
  • During the cardiopulmonary bypass, blood is mixed directly through the homologous blood transfusion, but homologous blood may be not compatible, acceptable or available. (
  • RAP is a blood conservation technique to decrease the priming volume of cardiopulmonary bypass and then reduce the level of the hemodilution. (
  • To be more specific, some cardiopulmonary bypass circuit prime are replaced by autologous circulating blood at the beginning of bypass in both venous cannula and arterial cannula. (
  • Quality of intraoperative autologous blood withdrawal used for retransfusion after cardiopulmonary bypass. (
  • To address an increase in blood product usage since the discontinuation of aprotinin, blood conservation strategies were initiated at a tertiary hospital in Oakland, CA. Improving transfusion rates for open heart surgery patients requiring Cardiopulmonary bypass (CPB) involved multiple departments in coordination. (
  • The aim was to evaluate the predictive value of thromboelastometry for postoperative blood loss in adult cardiac surgery with cardiopulmonary bypass. (
  • One of the most important techniques in order to avoid the hemodilution caused by priming solutions during Cardiopulmonary Bypass (CPB) is Retrograde Autologous Priming (ROP). (
  • In recent years, the risks of blood transfusion have been highlighted by the reports of the Serious Hazards of Transfusion scheme (SHOT), which collects data on adverse events related to transfusion. (
  • We conducted an open-label phase I study using autologous umbilical cord blood infusion to ameliorate type 1 diabetes. (
  • No infusion-related adverse events were observed. (
  • CONCLUSIONS Autologous UCB infusion in children with T1D is safe and induces changes in Treg frequency but fails to preserve C-peptide. (
  • On the basis of preclinical efficacy and safety data, we performed an unblinded observational pilot study to determine whether autologous UCB infusion could preserve remaining endogenous insulin production. (
  • No adverse events were observed in association with autologous UCB infusion. (
  • Allogeneic blood transfusion results in the infusion into the recipient of large amounts of foreign antigens in both soluble and cell-associated forms. (
  • A possible compromise may be to delay clamping for sufficient time to allow a transient infusion of blood to the infant (30-60 seconds) without significantly compromising the volume of cord blood obtained for banking. (
  • Stored RBCs were analyzed for in vivo 24-hour recovery, hemolysis, metabolic variables, blood group antigen expression, neoantigen formation, and safety after autologous infusion. (
  • No serious or unexpected adverse events were observed after infusion of P-Capt-filtered full-volume RBC units. (
  • During stable stage of disease, the CIK cell infusion could reduce the red blood cell infusion amount and stabilize hemoglobin level. (
  • It is concluded that the autologous CIK cell infusion is a safe and effective therapy for geriatric myelodysplastic syndrome. (
  • The present invention relates to a system for the collection and re-infusion of blood in to a human body just before surgery. (
  • More specifically, it is a system and method for the collection and re-infusion blood to human body. (
  • It is used for collecting the blood just before the surgery within a short span of time and anti-coagulating patient's blood for re-infusion in to the same patient. (
  • More specifically, it is a system for the collection of blood from human body (an eligible patient) just before surgery and re-infusion to the same person. (
  • The proposed invention will be used for collecting blood just before surgery within a short span of time and anti-coagulating patient's blood for re-infusion in to the same patient on the operation theater (OT) table prior to the surgery. (
  • Ways to avoid the adverse events associated with allogenic transfusion are often grouped under the umbrella phrase bloodless surgery. (
  • Two important risk factors are preoperative anemia and perioperative erythrocyte transfusion. (
  • The purpose of this study was to determine the effect of erythrocyte transfusion on the development of acute kidney injury. (
  • Conclusions Administration of autologous bone marrow derived MSCs appears safe and feasible in the treatment of refractory Crohn's disease. (
  • The overall 'number needed to treat' derived for patients receiving epoetin subcutaneously was 4.4, which suggests that 4 to 5 patients must be treated with epoetin to spare one patient from transfusion. (
  • This is usually done as a lifesaving maneuver to replace blood cells or blood products lost through severe bleeding, during surgery when blood loss occurs or to increase the blood count in an anemic patient. (
  • This assures the blood is given to the correct patient. (
  • The patient is expected to lose sufficient blood in the perioperative period so as to require RBC transfusion, and autotransfusion will likely reduce or eliminate the need for allogeneic blood transfusion. (
  • Religious beliefs cause the patient to refuse allogeneic transfusion, but accept autologous transfusion. (
  • The patient is unable to donate sufficient quantities of autologous blood prior to surgery to adequately cover the anticipated transfusion requirement. (
  • The mean number of units of homologous blood transfused per patient was reduced from 0.86 to 0.12 (P (P (
  • HTRs are most often caused by ABO Blood type incompatibility between the Blood product needed by the patient and red Blood cells given the patient during transfusion. (
  • Antigen - A substance on the surface of red Blood cells that elicits an immune response when transfused into a patient who lacks that antigen. (
  • 2. The collection and reinfusion into the patient of blood lost during an operation. (
  • We identified 28,087 primary THR procedures performed from 1999 to 2007, from which we computed a propensity score for red blood cell transfusion based on detailed data on patient-, procedure-, and hospital-related characteristics. (
  • They speculate that those deemed to need transfusions might have been more at risk anyway: "The need for a transfusion could be an indicator of other prognostic factors that are either unknown or difficult to quantify, such as the extent of the tumour and the dissection, the skill of the surgeon, and the nutritional state of the patient. (
  • The current approach in perioperative bleeding management of the pediatric patient should focus on the diagnosis and treatment of anemia and coagulopathy with the transfusion of blood products only when clinically indicated and guided by goal-directed strategies. (
  • RECENT FINDINGS Current guidelines recommend that a comprehensive multimodal patient blood management strategy is critical in optimizing patient care, avoiding unnecessary transfusion of blood and blood product and limiting transfusion-related side-effects. (
  • the patient refused transfusion of stored autologous or allogeneic blood products for religious reasons. (
  • Specifically IOS is a medical procedure involving recovering blood lost during surgery and re-infusing it into the patient. (
  • Reduction in the use of blood products should therefore be a general desire for every patient due to the associated risk factors. (
  • The evolution of less invasive cardiac surgical approaches, such as CABG without CPB (OPCAB) may contribute to a further reduction of blood transfusion and although these minimally invasive techniques may benefit every patient, they might be particularly valuable for JW. (
  • In this report, we present our initial experience in JW patient undergoing OPCAB and the way to use patient blood management for improved surgical outcome in such patient. (
  • Transfusion-associated graft-versus-host disease (TAGVHD) occurs more frequently in certain immunocompromised patient groups. (
  • Interim results also showed that all but one patient with a non-β0/β0 genotype (12 of 13 patients) stopped receiving regular red blood cell (RBC) transfusions, with a median time since last transfusion of 27 months. (
  • Dr. Walters collected stem cells from transfusion-dependent beta-thalassemia major patients, inserted the healthy gene, and then infused the cells back into the patient after first giving high-dose chemotherapy to destroy the thalassemia-producing blood cells. (
  • Blood that a patient donates for his own use in a blood transfusion. (
  • Blood taken and given to the same patient to eliminate transfusion problems. (
  • Autologous blood donations are a method by which a patient donates their own blood which will later be used for themselves. (
  • A strategy for blood management is one of a number of critical components for successful patient care in joint arthroplasty. (
  • Hip and knee arthroplasty can result in substantial perioperative blood loss, putting the patient at risk for a blood transfusion [1,2]. (
  • Such a strategy should be individualized and based on patient-specific risk factors, including preoperative hemoglobin level, anticipated difficulty of the procedure and blood loss, and associated medical co-morbidities. (
  • The ultimate transfusion trigger should also be individualized based on the risks and benefits for each patient. (
  • In addition, this type of blood loss may increase the number of allogenic blood units transfused to each patient (3-4 per person) (5,6). (
  • As with Patient 1204, the first patient with SCD treated in HGB-205, these two patients received a more stringent busulfan conditioning regimen and regular blood transfusions prior to stem cell harvest. (
  • It is exciting to see the outcome in the patient with TDT with the longest follow-up in HGB-205, who has gone from years of regular transfusions to 3.5 years without a single blood transfusion after a one-time treatment with LentiGlobin gene therapy. (
  • To avoid these problems, blood from the same patient is collected just before the surgery on the OT table and transfused to the same patient during or after the surgery as per requirement To avoid drawbacks of conventional blood transfusions, autologous blood transfusion is highly suggested by Transfusion Medicine text books. (
  • Blood from the eligible patient is collected (before, during or after the surgery), stored temporarily and reinfused as needed during or after the surgery. (
  • As own blood is easily accepted by the body, it is an extremely safe way to help the patient in the recovery process. (
  • In this case, 2 or more units of autologous blood are collected from the patient on the OT table just before the surgery and the same volume is replaced with normal saline. (
  • The main idea of this normo volumic hemodilution is that whatever blood is lost by the patient (during surgery) is diluted blood. (
  • Lastly, the healthy stem cells are returned to the body to repopulate the blood cell count. (
  • The PRP procedure relies on the naturally-occurring growth factors and stem cells that are present in your blood. (
  • Renewed interest in this question comes from the potential impact that DCC may have on banking of the baby's cord blood and the concentration of stem cells returned to the infant versus cryopreserved for potential later use. (
  • While any reduction in volume can have an affect on the number of stem cells, an advanced cord blood-processing method called PrepaCyte-CB has been shown to be unaffected by volume. (
  • The aim of our study was to evaluate the levels of cytokines (osteopontin and angiopoietins 1 and 2) active in the bone marrow niche during the mobilisation of haematopoietic stem cells for autologous transplantation. (
  • Dr. Mark C. Walters of UCSF Benioff Children's Hospital Oakland has been the lead researcher for the Northstar Study (HGB-204): A Phase I/II Study of Gene Therapy for Beta-Thalassemia Major via Transplantation of Autologous Hematopoietic Stem Cells Transduced Ex-Vivo with a Lentiviral Beta AT87Q-Globin Vector (LentiGlobin BB305 Drug Product). (
  • LentiGlobin BB305, produced by BlueBird Bio, uses a non-communicable virus to deliver a fully functioning HBB gene to a patient's own blood-producing stem cells. (
  • The OrthoPAT orthopedic perioperative autotransfusion system is indicated for use to salvage RBCs from blood lost intraoperatively and postoperatively during surgical procedures where the expected rate of processing of salvaged blood and fluid aspirated from the surgical site is less than or equal to 2 liters per hour. (
  • On the basis of the immunomodulatory effect of allogeneic blood transfusion in renal allograft recipients, Gantt 14 raised the question in 1981 whether the TRIM effect might also be associated with an increased risk of cancer recurrence in patients undergoing resection of a malignancy. (
  • They found that patients receiving any type of transfusion, whether of their own blood (autologous) or donated (allogeneic) were at "significantly increased" risk of a recurrence of the disease compared with those not receiving blood. (
  • Several medical devices have been developed to assist in salvaging the patient's own blood in the perioperative setting. (
  • The patient's own blood. (
  • Autologous transfusion is defined as the collection and subsequent reinfusion of patient's own blood or blood ^ component. (
  • Use of patient's own blood that was withdrawn just before the surgery to replace the blood lost during surgery has been found to provide better perfusion and reduced blood loss due to the dilution of patient's blood. (
  • ROCKVILLE, Md-Epoetin alfa, or recombinant human erythropoietin (Epogen, Procrit), reduces the need for red blood cell (RBC) transfusions among cancer patients with chemotherapy-induced anemia, a report prepared for the Agency for Healthcare Research and Quality (AHRQ) concludes. (
  • Anemia - weakness, fatigue, and paleness resulting from a deficiency of red Blood cells or insufficient amounts of hemoglobin molecules within the red cells. (
  • Aplastic Anemia - An anemia caused by deficient red Blood cell production by the bone marrow. (
  • 7 , 12 - 16 In one study, moderate preoperative anemia (hemoglobin 10-12 g/dL) conferred a 60% increase and perioperative erythrocyte transfusions conferred an 8% per-unit increase in the odds of developing AKI. (
  • 7 In another study, the deleterious effects of perioperative transfusions were found to be more pronounced in patients with preexisting anemia than in those without anemia. (
  • For total hip arthroplasty (THA) and total knee arthroplasty (TKA), surgeons preoperatively screen hemoglobin levels to identify possible anemia cases and predict which patients may need postoperative transfusions. (
  • Transfusions of blood and blood products may be necessary to treat severe thrombocytopenia, leucopenia, and anemia resulting from a disease process or from treatment. (
  • Beta-thalassermia major, sometimes called Cooley's anemia, is a hereditary disorder caused by a genetic abnormality of the beta globin gene that results in defective red blood cells, the cells that carry oxygen to cells throughout the body via hemoglobin. (
  • The condition is characterized by patients suffering from chronic anemia, an increased risk for blood clots and generally requires a lifetime of regular transfusions. (
  • Dogs with blood loss anemia due to IMT will be included for comparison since they are hypothesized to have less inflammation than dogs with IMHA prior to transfusion. (
  • The major adverse effects of combination therapy were rash, asthenia, edema and musculoskeletal events, and combination therapy was more prone to inducing neutropenia, thrombocytopenia and mild anemia. (
  • A Phase 3, Multicenter, Randomized, Double-blind Study to Compare the Efficacy and Safety of Oral Azacitidine Plus Best Supportive Care Versus Placebo Plus Best Supportive Care in Subjects With Red Blood Cell Transfusion-dependent Anemia and Thrombocytopenia Due to IPSS Lower-risk Myelodysplastic Syndromes. (
  • OBJECTIVE: To assess the effect of packed RBC (pRBC) transfusion on thromboelastographic (TEG) tracings in dogs with naturally occurring anemia. (
  • Hemodilution leads to a decrease in the formed elements of the blood, especially in erythrocytes, and the blood's oxygen transport capacity is reduced due to hemodilutional anemia. (
  • The fundamental aim of a blood management strategy is to eliminate the need for allogenic blood while at the same time preventing anemia. (
  • Correcting anemia not only reduces the risk of allogenic transfusion, but it also has a positive impact on the patient's rehabilitation and functional recovery. (
  • Although several techniques are available to reduce blood loss in TKA, ABT is frequently practiced and might lead to anemia in TKA patients. (
  • Is preoperative anemia or perioperative ABT responsible for the adverse side effects of this technique? (
  • Hematologic tests show: mild to severe normocytic anemia normochromic anemia elevated, normal, or reduced white blood cell count differential with any combination of neutrophilia, lymphocytopenia, monocytosis, and eosinophilia. (
  • People with thalassemia cannot make enough hemoglobin in their red blood cells, which interferes with oxygen getting to all parts of the body. (
  • Most of the time a transfusion is not a 'whole blood' transfusion, but rather certain blood products, with red blood cells being the most common. (
  • Gantt's hypothesis was based on the premise that, if allogeneic blood transfusion down-regulated the host's immune surveillance mechanism that targets malignant cells, the receipt of allogeneic blood transfusion could enhance tumor growth. (
  • Agglutination - The clumping together of red cells in blood as a result of antibodies attaching to antigens on the surface of the cells. (
  • When different types of blood come into contact within the body as a result of a mismatched transfusion, the alien red cells usually burst instead of agglutinate. (
  • These cells are part of the formed elements of whole Blood. (
  • Antibody - Proteins that react with antigens on red Blood cells and may destroy transfused red Blood cells. (
  • Anisocytosis - Condition which is characterized by a considerable variation in the size of cells, especially red Blood cells. (
  • The cells were preserved in 10% DMSO/30% Plasmalyte A/22.5% autologous irradiated plasma and stored in liquid nitrogen. (
  • Where you would normally see a decline in red blood cells, hematocrit, and hemoglobin over the period of several days racing, someone transfusing themselves with their own blood would always have that same fresh and replenished baseline they started with. (
  • Hypotension and acute pulmonary insufficiency following transfusion of autologous red blood cells during surgery: a case report and review of the literature. (
  • Blood transfusions are a way to replace cells and healthy blood cell counts. (
  • Resistent, recurring, or advanced leukemia, and chemotherapy can significantly reduce the number of healthy blood cells in bone marrow. (
  • These factors are known to stimulate key skin cells such as fibroblasts and keratinocytes and can promote synthesis and remodeling of collagen and proteoglycans and sprouting of new blood vessels, vital for supporting healthy and youthful skin. (
  • Thanks to advances in medicine, we now know that blood is a complex "tissue" consisting of several types of cells and thousands of factors suspended in a liquid medium, known as plasma. (
  • While blood is normally contained within the circulation and cannot reach the cells and tissues of your skin, PRP procedure makes it possible to supply your skin with all those essential and revitalizing factors in a controlled and safe manner. (
  • In most situations, this is done as a lifesaving maneuver to replace blood cells or blood products lost through severe bleeding. (
  • It can be seen as a "pump" to serve as a heart-lung machine whose function is sustaining blood circulatory and transporting oxygen to red blood cells before blood is flowing backwards the arterial circulation. (
  • Homologous blood transfusion refers to using blood from other compatible donors to improve the oxygen-carrying capacity for blood by raising the number and concentration of blood red cells. (
  • There are two main ways to salvage red blood cells. (
  • Cell processors are red cell washing devices like the Cell Saver that collect anticoagulated shed or recovered blood, wash and separate the red blood cells (RBC) by centrifugation. (
  • The P-Capt filter has been shown to remove around 4 log ID 50 prion infectivity from prion-spiked human red blood cells (RBCs). (
  • Whole Blood consists of red blood cells (RBC), plasma, plasma proteins, and about 60 mL anticoagulant/preservative solution in a total volume of about 500 mL. (
  • The shelf-life of stored red blood cells (RBCs) is typically 42 and 35 days for human and canine RBCs, respectively. (
  • Objective of this study was to evaluate the effectiveness and safety of autologous cytokine induced killer (CIK) cells combined with IL-2 in treatment of elderly patients with myelodysplastic syndromes (MDS). (
  • The autologous CIK cells were then infused back into the corresponding patients. (
  • Filtration devices like HemoClear microfilter, constitute the second major type of blood salvage in operating rooms. (
  • Intraoperative blood salvage (IOS), also known as cell salvage, is a specific type of autologous blood transfusion. (
  • There are other religious/ non-religious individuals besides Jehovah's Witnesses that would refuse allogeneic blood products but may choose to accept intraoperative blood salvage. (
  • This study investigated the value and safety of salvage-type autologous blood transfusion during the endoscopic resection of juvenile nasopharyngeal angiofibromas (JNA). (
  • In all cases the intraoperative blood salvage apparatus was used. (
  • The use of cell salvage allows for single stage surgery without the need to abandon surgery due to excessive blood loss and its future use is promising. (
  • We sought to evaluate the safety, efficacy, and cost-effectiveness of intraoperative blood salvage (IBS) in off-pump coronary artery bypass grafting (OPCABG) surgery with different amount of bleeding. (
  • Autologous blood transfusion might be significantly beneficial for immune-compromised patients in the perioperative period, clearly showing its superiority over allogeneic blood transfusion. (
  • According to the results of our study, autologous blood transfusion is an efficient method that reduces allogeneic blood usage significantly in our circumstances as well. (
  • The disease free survival was significantly worse in patients in both groups who received transfusions than in the 143 patients who did not, whereas the disease free survival of the patients who received transfusions in both groups did not differ significantly from each other. (
  • The total blood loss in the TXA group was significantly lower than that in the control group 13 . (
  • Maximum amplitude significantly decreased from 74.9 to 73.8 mm and clot strength significantly decreased from 14,906 to 14,119 dynes/s after pRBC transfusion. (
  • When the amount of bleeding was 600-1000 ml, IBS can significantly reduce the demand for allogeneic blood, and has no direct adverse effects on coagulation function and recuperation, and is cost-effective in OPCABG. (
  • This may avoid the use of bank blood from unknown donors and significantly reduces the risk of acquiring transmitted diseases. (
  • Between 15 December 2003 and 21 November 2008, 24 children with T1D (10 males, 14 females) underwent a single autologous UCB transfusion. (
  • Blood Coagulation & Fibrinolysis. (
  • The blood is collected into a sterile and sealed special tube to avoid coagulation (formation of blood clots) and contamination, which will bear your name to avoid any mix-up. (
  • Retrograde Autologous Priming as a Safe and Easy Method to Reduce Hemodilution and Transfusion Requirements during Cardiac Surgery. (
  • Retrograde autologous priming (RAP) is a means to effectively and safely restrict the hemodilution caused by the direct homologous blood transfusion and reduce the blood transfusion requirements during cardiac surgery. (
  • These adverse effects facilitate the development of approaches to conserve the blood during cardiac surgery. (
  • Furthermore, the number of patients requiring red blood transfusions could be anticipated by observing a variety of variables before cardiac surgery. (
  • The use of TXA has been shown to be effective in reducing postoperative blood loss in cardiac 9 , dental 10 and spinal surgery 11 . (
  • Blood product usage is a quality outcome for patients undergoing cardiac surgery. (
  • There were no adverse effects from using the autologous system and it does reduce the need for a homologous blood transfusion. (
  • Exclusive or supplemental use of autologous Blood can eliminate or reduce adverse effects of transfusion. (
  • Traditional bleeding management has consisted of transfusion of autologous blood products, however, there is strong evidence that transfusion-related side-effects are associated with increased morbidity and mortality in children. (
  • The aim of this study is to investigate the effects of tranexamic acid on hemorrhage, blood transfusion, fibrin degradation products and kidney functions for total hip arthroplasty. (
  • Tranexamic acid compared with high-dose aprotinin in primary elective heart operations: effects on perioperative bleeding and allogeneic transfusions. (
  • Adverse effects of anaemia include need for transfusion, longer hospital stay and associated increased costs. (
  • We performed a randomized controlled trial of 99 patients who underwent a TKA, comparing the local effects of TXA in reducing postoperative blood loss and reducing the need for postoperative transfusion. (
  • Discussing Adverse Effects. (
  • Effector cell proportion changes, adverse effects, effects on inflammation, hemoglobin level and blood transfusion were assessed after treatment. (
  • No severe adverse effects were observed in all patients. (
  • For a dissociative disorder characterized by intense fear, impending disaster or death accompanied by local antimicrobial susceptibility data, as more relevant than other lubricating preparations, and among the most serious adverse effects. (
  • Clinically significant adverse effects were not detected. (
  • On the other hand, the effectiveness of new methods used to prevent blood loss remains a matter of question since all these methods are associated with certain adverse side effects. (
  • Larger randomized studies as well as 2-year postinfusion follow-up of this cohort are needed to determine whether autologous cord blood-based approaches can be used to slow the decline of endogenous insulin production in children with type 1 diabetes. (
  • All blood components are administered through specifically designed intravenous giving sets, which incorporate a 170-200 micron filter to remove debris and clots that may have accumulated during storage. (
  • Crystalloid and colloid solutions containing calcium (eg, Haemaccel) must never be added to or administered through the same intravenous line as blood or component collected in an anticoagulant containing citrate because they interfere with the anticoagulant effect, resulting in clotting. (
  • ICS autologous blood transfusions reduce the need for allogenic blood transfusions. (
  • The phenotype/genotype relationship of patients with transfusion-dependent thalassaemia (TDT) is particularly complex and variable, thus generating different levels of severity and of annual transfusion volume (ATV). (
  • We collected data on one-hundred and twenty-seven patients with transfusion-dependent ß-thalassaemia followed at Rare Blood Cell Disease Unit, AORN Cardarelli Hospital. (
  • Deferasirox and deferiprone are the only two oral chelators used in adult patients with transfusion-dependent haemoglobinopathies. (
  • The results of the trials "Gene Therapy in Patients with Transfusion-Dependentβ-Thalassemia," are published today in the New England Journal of Medicine (NEJM). (
  • Randomized controlled trials are needed to determine whether initiating treatment at baseline hemoglobin levels greater than 10 g/dL provides additional benefits in reducing the need for transfusions or improving quality of life,' the report stated. (
  • The research showed that one dose of bluebird's autologous therapy successfully replaced malfunctioning genes with functional ones, leading to substantial increases in hemoglobin levels within 2 - 4.5 months. (
  • Several studies have highlighted the significant influence of preoperative hemoglobin on the requirement for transfusion in total joint arthroplasty [10,12]. (
  • Salido et al demonstrated that few patients with a preoperative hemoglobin level greater than 150 g/L need allogenic blood, while patients with preoperative hemoglobin level less than 110 g/L had a 100% transfusion rate [12]. (
  • Similarly, Pierson et al showed that an algorithm-based strategy aimed at improving the preoperative hemoglobin level was effective in reducing transfusion rate [10]. (
  • A postoperative hemoglobin level of between 80 and 100 g/dL may not be low enough to warrant transfusion, but these patients often feel lethargic and have a higher risk of syncopal episodes, impairing their ability to mobilize and participate in rehabilitation. (
  • However, the new study finds that epoetin is unlikely to spare such patients from transfusion because they are uniformly anemic following bone marrow ablation, and their response to erythropoietin, whether natural or recombinant, is not immediate. (
  • Autologous blood transfusion with recombinant erythropoietin treatment. (
  • To avoid allogeneic transfusions, beneficial blood saving methods include various strategies, such as autologous deposits, normovolemic haemodilution and various agents including aprotinin, tranecamic acid, desmopressin and erythropoietin, but their use in hospital shows considerable variations. (
  • People with Type O, negative blood are considered universal donors as it is safe to transfuse to nearly everyone. (
  • The National Blood Service currently collects about 2.5 million donations of blood from voluntary unremunerated donors in the UK every year, but only about 3% of the blood and blood products are transfused to children under 16 years of age. (
  • So in terms of viral transmission, blood transfusion is much safer than in the 1960s when the risk of contracting hepatitis was as high as 1 in 5 associated with the use of paid donors in the USA. (
  • Other risks such as classic or variant Creutzfeldt-Jakob disease (vCJD), an invariably fatal disease, remain worrisome as there are currently no approved tests for which to screen blood donors for this disease. (
  • Blood centers worldwide have instituted criteria to reject donors who may have been exposed to classic CJD and vCJD. (
  • In many industrialized countries 5% or less of the eligible population are blood donors. (
  • This stratagem was first introduced in 2007 and since July 2012, 100% of FFP and cryoprecipitate issued by the Blood Service has come from male donors. (
  • Allogeneic hematopoietic cell transplantation (HCT) is currently the only cure but it has several limitations including the paucity of human leukocyte antigen-matched related donors and a high risk of adverse events. (
  • The minimal extracorporeal circulation (MECC) system and the technique of retrograde autologous priming (RAP) of a conventional CPB circuit have been associated with decreased hemodilution. (
  • There are two primary methods, homologous blood transfusion and autologous blood transfusion, to reduce the massive blood loss resulted from different surgeries. (
  • Furthermore, a significant risk caused by the homologous blood transfusion in open-heart surgeries is hemodilution. (
  • Homologous blood transfusion could be avoided in all cases. (
  • Homologous blood transfusion can be avoided by using this technique. (
  • In conclusion, RAP is compared with cCPB and MECC a safe and low-cost technique in reducing the priming volume of the CPB system, causes less hemodilution, and reduces the need for intra- and postoperative blood transfusion. (
  • There are other multiple risks of blood transfusion when blood from individual is transfused to another individual (homologous or ordinary blood transfusion). (
  • Antiserum - Human Blood serum containing antibodies that are specific for one or more antigens. (
  • Most commonly, there is an immune-mediated hemolysis involving alloantibodies, which may be naturally occurring or the result of an earlier transfusion, in the recipient's serum and the donor's erythrocytes. (
  • Generally, a minimum of 6 mL of whole blood yielding at least 3 mL of serum required to provide adequate specimen volume for antibody and compatibility testing. (
  • We hypothesized that the use of amniotic membrane, topical autologous serum eye drops and systemic immunosuppression may have therapeutic benefit," Prof. Campbell explained. (
  • These findings suggest that the criteria for perioperative blood transfusion should be revised, considering potential risks. (
  • Pharmacologic agents such as aprotinin, tranexamic acid, or epsilon-aminocaproic acid (EACA) could reduce perioperative blood loss by interfering with fibrinolysis. (
  • studied the efficacy of TXA in reducing perioperative blood loss following cervical laminoplasty. (