Tissue that supports and binds other tissues. It consists of CONNECTIVE TISSUE CELLS embedded in a large amount of EXTRACELLULAR MATRIX.
Nutrient blood vessels which supply the walls of large arteries or veins.
The middle layer of blood vessel walls, composed principally of thin, cylindrical, smooth muscle cells and elastic tissue. It accounts for the bulk of the wall of most arteries. The smooth muscle cells are arranged in circular layers around the vessel, and the thickness of the coat varies with the size of the vessel.
The innermost layer of an artery or vein, made up of one layer of endothelial cells and supported by an internal elastic lamina.
Either of the two principal arteries on both sides of the neck that supply blood to the head and neck; each divides into two branches, the internal carotid artery and the external carotid artery.
Connective tissue comprised chiefly of elastic fibers. Elastic fibers have two components: ELASTIN and MICROFIBRILS.
The nonstriated involuntary muscle tissue of blood vessels.
The main trunk of the systemic arteries.
The outermost covering of organs, blood vessels, and other such structures in the body.
Arteries arising from the external carotid or the maxillary artery and distributing to the temporal region.
The portion of the descending aorta proceeding from the arch of the aorta and extending to the DIAPHRAGM, eventually connecting to the ABDOMINAL AORTA.
The veins and arteries of the HEART.
The aorta from the DIAPHRAGM to the bifurcation into the right and left common iliac arteries.
Damages to the CAROTID ARTERIES caused either by blunt force or penetrating trauma, such as CRANIOCEREBRAL TRAUMA; THORACIC INJURIES; and NECK INJURIES. Damaged carotid arteries can lead to CAROTID ARTERY THROMBOSIS; CAROTID-CAVERNOUS SINUS FISTULA; pseudoaneurysm formation; and INTERNAL CAROTID ARTERY DISSECTION. (From Am J Forensic Med Pathol 1997, 18:251; J Trauma 1994, 37:473)
An increase in the number of cells in a tissue or organ without tumor formation. It differs from HYPERTROPHY, which is an increase in bulk without an increase in the number of cells.
The main artery of the thigh, a continuation of the external iliac artery.
Any of the tubular vessels conveying the blood (arteries, arterioles, capillaries, venules, and veins).
The application of a caustic substance, a hot instrument, an electric current, or other agent to control bleeding while removing or destroying tissue.
The two principal arteries supplying the structures of the head and neck. They ascend in the neck, one on each side, and at the level of the upper border of the thyroid cartilage, each divides into two branches, the external (CAROTID ARTERY, EXTERNAL) and internal (CAROTID ARTERY, INTERNAL) carotid arteries.
The new and thickened layer of scar tissue that forms on a PROSTHESIS, or as a result of vessel injury especially following ANGIOPLASTY or stent placement.
The vessels carrying blood away from the heart.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
The vessels carrying blood away from the capillary beds.
A group of cells that includes FIBROBLASTS, cartilage cells, ADIPOCYTES, smooth muscle cells, and bone cells.
A proteolytic enzyme obtained from the venom of fer-de-lance (Bothrops atrox). It is used as a plasma clotting agent for fibrinogen and for the detection of fibrinogen degradation products. The presence of heparin does not interfere with the clotting test. Hemocoagulase is a mixture containing batroxobin and factor X activator. EC 3.4.21.-.
Single pavement layer of cells which line the luminal surface of the entire vascular system and regulate the transport of macromolecules and blood components.
Use or insertion of a tubular device into a duct, blood vessel, hollow organ, or body cavity for injecting or withdrawing fluids for diagnostic or therapeutic purposes. It differs from INTUBATION in that the tube here is used to restore or maintain patency in obstructions.
Thickening and loss of elasticity of the walls of ARTERIES of all sizes. There are many forms classified by the types of lesions and arteries involved, such as ATHEROSCLEROSIS with fatty lesions in the ARTERIAL INTIMA of medium and large muscular arteries.
INFLAMMATION of any ARTERIES.
Connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules.
A systemic autoimmune disorder that typically affects medium and large ARTERIES, usually leading to occlusive granulomatous vasculitis with transmural infiltrate containing multinucleated GIANT CELLS. The TEMPORAL ARTERY is commonly involved. This disorder appears primarily in people over the age of 50. Symptoms include FEVER; FATIGUE; HEADACHE; visual impairment; pain in the jaw and tongue; and aggravation of pain by cold temperatures. (From Adams et al., Principles of Neurology, 6th ed)
Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).
The artery formed by the union of the right and left vertebral arteries; it runs from the lower to the upper border of the pons, where it bifurcates into the two posterior cerebral arteries.
Either of two large arteries originating from the abdominal aorta; they supply blood to the pelvis, abdominal wall and legs.
Inflammation of the wall of the AORTA.
A thickening and loss of elasticity of the walls of ARTERIES that occurs with formation of ATHEROSCLEROTIC PLAQUES within the ARTERIAL INTIMA.
The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.
The physiological narrowing of BLOOD VESSELS by contraction of the VASCULAR SMOOTH MUSCLE.
Drugs used to cause constriction of the blood vessels.
A flavoprotein that reversibly oxidizes NADPH to NADP and a reduced acceptor. EC 1.6.99.1.
Non-striated, elongated, spindle-shaped cells found lining the digestive tract, uterus, and blood vessels. They are derived from specialized myoblasts (MYOBLASTS, SMOOTH MUSCLE).
Study of intracellular distribution of chemicals, reaction sites, enzymes, etc., by means of staining reactions, radioactive isotope uptake, selective metal distribution in electron microscopy, or other methods.
The short wide vessel arising from the conus arteriosus of the right ventricle and conveying unaerated blood to the lungs.
Use of a balloon catheter for dilation of an occluded artery. It is used in treatment of arterial occlusive diseases, including renal artery stenosis and arterial occlusions in the leg. For the specific technique of BALLOON DILATION in coronary arteries, ANGIOPLASTY, BALLOON, CORONARY is available.
Veins in the neck which drain the brain, face, and neck into the brachiocephalic or subclavian veins.
The arterial blood vessels supplying the CEREBRUM.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
Inflammation of any one of the blood vessels, including the ARTERIES; VEINS; and rest of the vasculature system in the body.
An abnormal balloon- or sac-like dilatation in the wall of the ABDOMINAL AORTA which gives rise to the visceral, the parietal, and the terminal (iliac) branches below the aortic hiatus at the diaphragm.
The physiological widening of BLOOD VESSELS by relaxing the underlying VASCULAR SMOOTH MUSCLE.
A flavoprotein enzyme that catalyzes the univalent reduction of OXYGEN using NADPH as an electron donor to create SUPEROXIDE ANION. The enzyme is dependent on a variety of CYTOCHROMES. Defects in the production of superoxide ions by enzymes such as NADPH oxidase result in GRANULOMATOUS DISEASE, CHRONIC.
Obstruction of flow in biological or prosthetic vascular grafts.
Non-human animals, selected because of specific characteristics, for use in experimental research, teaching, or testing.
Colorless to yellow dye that is reducible to blue or black formazan crystals by certain cells; formerly used to distinguish between nonbacterial and bacterial diseases, the latter causing neutrophils to reduce the dye; used to confirm diagnosis of chronic granulomatous disease.
An octapeptide that is a potent but labile vasoconstrictor. It is produced from angiotensin I after the removal of two amino acids at the C-terminal by ANGIOTENSIN CONVERTING ENZYME. The amino acid in position 5 varies in different species. To block VASOCONSTRICTION and HYPERTENSION effect of angiotensin II, patients are often treated with ACE INHIBITORS or with ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS.
Resistance and recovery from distortion of shape.
The introduction of functional (usually cloned) GENES into cells. A variety of techniques and naturally occurring processes are used for the gene transfer such as cell hybridization, LIPOSOMES or microcell-mediated gene transfer, ELECTROPORATION, chromosome-mediated gene transfer, TRANSFECTION, and GENETIC TRANSDUCTION. Gene transfer may result in genetically transformed cells and individual organisms.
A purely physical condition which exists within any material because of strain or deformation by external forces or by non-uniform thermal expansion; expressed quantitatively in units of force per unit area.
Device constructed of either synthetic or biological material that is used for the repair of injured or diseased blood vessels.
The vein which drains the foot and leg.
The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)
The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.
Homopolymer of tetrafluoroethylene. Nonflammable, tough, inert plastic tubing or sheeting; used to line vessels, insulate, protect or lubricate apparatus; also as filter, coating for surgical implants or as prosthetic material. Synonyms: Fluoroflex; Fluoroplast; Ftoroplast; Halon; Polyfene; PTFE; Tetron.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
An abnormal balloon- or sac-like dilatation in the wall of AORTA.
The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)
A family of non-enveloped viruses infecting mammals (MASTADENOVIRUS) and birds (AVIADENOVIRUS) or both (ATADENOVIRUS). Infections may be asymptomatic or result in a variety of diseases.
Theoretical representations that simulate the behavior or activity of the cardiovascular system, processes, or phenomena; includes the use of mathematical equations, computers and other electronic equipment.
A polypeptide substance comprising about one third of the total protein in mammalian organisms. It is the main constituent of SKIN; CONNECTIVE TISSUE; and the organic substance of bones (BONE AND BONES) and teeth (TOOTH).
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
Filamentous proteins that are the main constituent of the thin filaments of muscle fibers. The filaments (known also as filamentous or F-actin) can be dissociated into their globular subunits; each subunit is composed of a single polypeptide 375 amino acids long. This is known as globular or G-actin. In conjunction with MYOSINS, actin is responsible for the contraction and relaxation of muscle.
Methods of preparing tissue for examination and study of the origin, structure, function, or pathology.
Pathological conditions involving the CAROTID ARTERIES, including the common, internal, and external carotid arteries. ATHEROSCLEROSIS and TRAUMA are relatively frequent causes of carotid artery pathology.
Pathological processes of CORONARY ARTERIES that may derive from a congenital abnormality, atherosclerotic, or non-atherosclerotic cause.
A class of protein components which can be found in several lipoproteins including HIGH-DENSITY LIPOPROTEINS; VERY-LOW-DENSITY LIPOPROTEINS; and CHYLOMICRONS. Synthesized in most organs, Apo E is important in the global transport of lipids and cholesterol throughout the body. Apo E is also a ligand for LDL receptors (RECEPTORS, LDL) that mediates the binding, internalization, and catabolism of lipoprotein particles in cells. There are several allelic isoforms (such as E2, E3, and E4). Deficiency or defects in Apo E are causes of HYPERLIPOPROTEINEMIA TYPE III.
A group of enzymes that catalyzes the hydrolysis of terminal, non-reducing beta-D-galactose residues in beta-galactosides. Deficiency of beta-Galactosidase A1 may cause GANGLIOSIDOSIS, GM1.
A species of SWINE, in the family Suidae, comprising a number of subspecies including the domestic pig Sus scrofa domestica.
Elements of limited time intervals, contributing to particular results or situations.
Tear or break of an organ, vessel or other soft part of the body, occurring in the absence of external force.
An intermediate filament protein found predominantly in smooth, skeletal, and cardiac muscle cells. Localized at the Z line. MW 50,000 to 55,000 is species dependent.
Nuclear antigen with a role in DNA synthesis, DNA repair, and cell cycle progression. PCNA is required for the coordinated synthesis of both leading and lagging strands at the replication fork during DNA replication. PCNA expression correlates with the proliferation activity of several malignant and non-malignant cell types.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
A particular zone of tissue composed of a specialized microenvironment where stem cells are retained in a undifferentiated, self-renewable state.
The maximum stress a material subjected to a stretching load can withstand without tearing. (McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed, p2001)
Pathological processes involving any part of the AORTA.
Muscular contractions characterized by increase in tension without change in length.
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
Microscopy using an electron beam, instead of light, to visualize the sample, thereby allowing much greater magnification. The interactions of ELECTRONS with specimens are used to provide information about the fine structure of that specimen. In TRANSMISSION ELECTRON MICROSCOPY the reactions of the electrons that are transmitted through the specimen are imaged. In SCANNING ELECTRON MICROSCOPY an electron beam falls at a non-normal angle on the specimen and the image is derived from the reactions occurring above the plane of the specimen.
Pathological processes involving any of the BLOOD VESSELS in the cardiac or peripheral circulation. They include diseases of ARTERIES; VEINS; and rest of the vasculature system in the body.
The movement of cells from one location to another. Distinguish from CYTOKINESIS which is the process of dividing the CYTOPLASM of a cell.
Relatively undifferentiated cells that retain the ability to divide and proliferate throughout postnatal life to provide progenitor cells that can differentiate into specialized cells.
A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.
Spasm of the large- or medium-sized coronary arteries.
A CALCIUM-dependent, constitutively-expressed form of nitric oxide synthase found primarily in ENDOTHELIAL CELLS.
The condition of an anatomical structure's being constricted beyond normal dimensions.
Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic.
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
The properties, processes, and behavior of biological systems under the action of mechanical forces.
A technique that localizes specific nucleic acid sequences within intact chromosomes, eukaryotic cells, or bacterial cells through the use of specific nucleic acid-labeled probes.
Slender processes of NEURONS, including the AXONS and their glial envelopes (MYELIN SHEATH). Nerve fibers conduct nerve impulses to and from the CENTRAL NERVOUS SYSTEM.
A secreted endopeptidase homologous with INTERSTITIAL COLLAGENASE, but which possesses an additional fibronectin-like domain.
Aneurysm caused by a tear in the TUNICA INTIMA of a blood vessel leading to interstitial HEMORRHAGE, and splitting (dissecting) of the vessel wall, often involving the AORTA. Dissection between the intima and media causes luminal occlusion. Dissection at the media, or between the media and the outer adventitia causes aneurismal dilation.
An NADPH-dependent enzyme that catalyzes the conversion of L-ARGININE and OXYGEN to produce CITRULLINE and NITRIC OXIDE.
Postmortem examination of the body.
ENDOPEPTIDASES which use a metal such as ZINC in the catalytic mechanism.
A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.
A species of the genus MACACA which typically lives near the coast in tidal creeks and mangrove swamps primarily on the islands of the Malay peninsula.
A strain of Rattus norvegicus used as a normotensive control for the spontaneous hypertensive rats (SHR).
Relatively complete absence of oxygen in one or more tissues.
A subtype of endothelin receptor found predominantly in the KIDNEY. It may play a role in reducing systemic ENDOTHELIN levels.
The development of new BLOOD VESSELS during the restoration of BLOOD CIRCULATION during the healing process.
Highly reactive compounds produced when oxygen is reduced by a single electron. In biological systems, they may be generated during the normal catalytic function of a number of enzymes and during the oxidation of hemoglobin to METHEMOGLOBIN. In living organisms, SUPEROXIDE DISMUTASE protects the cell from the deleterious effects of superoxides.
A layer of epithelium that lines the heart, blood vessels (ENDOTHELIUM, VASCULAR), lymph vessels (ENDOTHELIUM, LYMPHATIC), and the serous cavities of the body.
A subtype of endothelin receptor found predominantly in the VASCULAR SMOOTH MUSCLE. It has a high affinity for ENDOTHELIN-1 and ENDOTHELIN-2.
Unstriated and unstriped muscle, one of the muscles of the internal organs, blood vessels, hair follicles, etc. Contractile elements are elongated, usually spindle-shaped cells with centrally located nuclei. Smooth muscle fibers are bound together into sheets or bundles by reticular fibers and frequently elastic nets are also abundant. (From Stedman, 25th ed)
Enzymes that catalyze the degradation of collagen by acting on the peptide bonds.
Arteries which arise from the abdominal aorta and distribute to most of the intestines.
Techniques used for determining the values of photometric parameters of light resulting from LUMINESCENCE.
Granulated cells that are found in almost all tissues, most abundantly in the skin and the gastrointestinal tract. Like the BASOPHILS, mast cells contain large amounts of HISTAMINE and HEPARIN. Unlike basophils, mast cells normally remain in the tissues and do not circulate in the blood. Mast cells, derived from the bone marrow stem cells, are regulated by the STEM CELL FACTOR.
Transplantation between individuals of the same species. Usually refers to genetically disparate individuals in contradistinction to isogeneic transplantation for genetically identical individuals.
The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.
The degree to which BLOOD VESSELS are not blocked or obstructed.
An endopeptidase that is structurally similar to MATRIX METALLOPROTEINASE 2. It degrades GELATIN types I and V; COLLAGEN TYPE IV; and COLLAGEN TYPE V.
A pathologic process consisting of the proliferation of blood vessels in abnormal tissues or in abnormal positions.
A type of stress exerted uniformly in all directions. Its measure is the force exerted per unit area. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
Drugs used to cause dilation of the blood vessels.
Pathologic deposition of calcium salts in tissues.
Pathological processes which result in the partial or complete obstruction of ARTERIES. They are characterized by greatly reduced or absence of blood flow through these vessels. They are also known as arterial insufficiency.
Any of the ruminant mammals with curved horns in the genus Ovis, family Bovidae. They possess lachrymal grooves and interdigital glands, which are absent in GOATS.
White blood cells. These include granular leukocytes (BASOPHILS; EOSINOPHILS; and NEUTROPHILS) as well as non-granular leukocytes (LYMPHOCYTES and MONOCYTES).
Microscopy in which the object is examined directly by an electron beam scanning the specimen point-by-point. The image is constructed by detecting the products of specimen interactions that are projected above the plane of the sample, such as backscattered electrons. Although SCANNING TRANSMISSION ELECTRON MICROSCOPY also scans the specimen point by point with the electron beam, the image is constructed by detecting the electrons, or their interaction products that are transmitted through the sample plane, so that is a form of TRANSMISSION ELECTRON MICROSCOPY.
Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.
Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.
All of the processes involved in increasing CELL NUMBER including CELL DIVISION.
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding.
Narrowing or stricture of any part of the CAROTID ARTERIES, most often due to atherosclerotic plaque formation. Ulcerations may form in atherosclerotic plaques and induce THROMBUS formation. Platelet or cholesterol emboli may arise from stenotic carotid lesions and induce a TRANSIENT ISCHEMIC ATTACK; CEREBROVASCULAR ACCIDENT; or temporary blindness (AMAUROSIS FUGAX). (From Adams et al., Principles of Neurology, 6th ed, pp 822-3)
Generating tissue in vitro for clinical applications, such as replacing wounded tissues or impaired organs. The use of TISSUE SCAFFOLDING enables the generation of complex multi-layered tissues and tissue structures.
DNA molecules capable of autonomous replication within a host cell and into which other DNA sequences can be inserted and thus amplified. Many are derived from PLASMIDS; BACTERIOPHAGES; or VIRUSES. They are used for transporting foreign genes into recipient cells. Genetic vectors possess a functional replicator site and contain GENETIC MARKERS to facilitate their selective recognition.
PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.
Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
A neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system.
Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.
The range or frequency distribution of a measurement in a population (of organisms, organs or things) that has not been selected for the presence of disease or abnormality.
The number of CELLS of a specific kind, usually measured per unit volume or area of sample.
An immune response with both cellular and humoral components, directed against an allogeneic transplant, whose tissue antigens are not compatible with those of the recipient.
The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
Techniques and strategies which include the use of coding sequences and other conventional or radical means to transform or modify cells for the purpose of treating or reversing disease conditions.
Differentiation antigens residing on mammalian leukocytes. CD stands for cluster of differentiation, which refers to groups of monoclonal antibodies that show similar reactivity with certain subpopulations of antigens of a particular lineage or differentiation stage. The subpopulations of antigens are also known by the same CD designation.
Highly specialized EPITHELIAL CELLS that line the HEART; BLOOD VESSELS; and lymph vessels, forming the ENDOTHELIUM. They are polygonal in shape and joined together by TIGHT JUNCTIONS. The tight junctions allow for variable permeability to specific macromolecules that are transported across the endothelial layer.
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.
A technique of inputting two-dimensional images into a computer and then enhancing or analyzing the imagery into a form that is more useful to the human observer.
A meshwork-like substance found within the extracellular space and in association with the basement membrane of the cell surface. It promotes cellular proliferation and provides a supporting structure to which cells or cell lysates in culture dishes adhere.
A common name used for the genus Cavia. The most common species is Cavia porcellus which is the domesticated guinea pig used for pets and biomedical research.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. The TGF-beta proteins are synthesized as precursor proteins.
Proteins prepared by recombinant DNA technology.
An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.
Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.
Test for tissue antigen using either a direct method, by conjugation of antibody with fluorescent dye (FLUORESCENT ANTIBODY TECHNIQUE, DIRECT) or an indirect method, by formation of antigen-antibody complex which is then labeled with fluorescein-conjugated anti-immunoglobulin antibody (FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT). The tissue is then examined by fluorescence microscopy.
The relationship between the dose of an administered drug and the response of the organism to the drug.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.

Gene profile for differentiation of vascular adventitial myofibroblasts. (1/30)

Our previous study demonstrated that TGF-beta1 could induce the differentiation of vascular adventitial fibroblasts (AFs) to myofibroblasts (MFs). The aim of this study was to identify the genes which might be responsible for the cell phenotypic change using genechips. Cultured rat AFs were treated with TGF-beta1 (10 ng/ml) for 0 min, 5 min, 15 min, 2 h, 12 h and 24 h, respectively. Then the cells were gathered to prepare total RNA. We examined TGF-beta1-induced gene expression profiling using Affymetrix oligonucleotide microarrays and analyzed data by GCOS1.2 software. Moreover, expressional similarity was measured by hierarchical clustering. Some of genechip results were confirmed by real-time quantitative RT-PCR. Microarray analysis identified 2121 genes with a 2-fold change or above after TGF-beta1 stimulation. 1318 genes showed a greater than 2-fold increase and 761 genes were reduced 2 folds or more at mRNA levels, whereas a small portion of the total regulated genes (42 genes) displayed dynamically up- and down-regulated pattern. Genes were further segregated for early (peak at 5 min, 15 min and/or 2 h), late (peak at 12 h and/or 24 h), and sustained (2-fold change or above at five time points) temporal response groups according to the time of their peak expression level. Among 1318 up-regulated genes, 333 genes (25.3%) responded rapidly to TGF-beta1 and 159 genes (12.1%) responded in a sustained manner. Most genes (826, 62.6%) were regulated at 12 h or later. For the 761 down-regulated genes, numbers of early and late responsive genes were 335 (44%) and 267 (36.1%), respectively. There were also 159 genes, 19.9% of total down-regulated genes, decreased at five time points treated by TGF-beta1. The results suggested that the gene expressions of secreted phosphoprotein 1 (APP1) and Rho-associated coiled-coil forming kinase 2 (ROCK2) had the same trends as alpha-smooth muscle-actin, a marker of MF differentiation. In addition, the gene expression of potassium voltage-gated channel, Shal-related family and member 2 (KCND2) was up-regulated. Furthermore, it was found that endothelin 1 (EDN1), some complement components, NADPH oxidase 4 (NOX4) and NAD(P)H dehydrogenase, quinone 1 (NQO1) might be involved in MF differentiation. Using microarrary technique, we confirmed some genes that have been identified by other techniques were implicated in MF differentiation and observed new genes involved in this process. Our results suggest that gene expression profiling study is helpful in identifying genes and pathways potentially involved in cell differentiation.  (+info)

Neovascularization of coronary tunica intima (DIT) is the cause of coronary atherosclerosis. Lipoproteins invade coronary intima via neovascularization from adventitial vasa vasorum, but not from the arterial lumen: a hypothesis. (2/30)

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Hypoxia induces unique proliferative response in adventitial fibroblasts by activating PDGFbeta receptor-JNK1 signalling. (3/30)

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Adventitial inversion with graft telescopic insertion for distal anastomosis in acute type a aortic dissection. (4/30)

PURPOSE: One current method of anastomosis in aortic dissection type A is the adventitial inversion technique. To improve hemostasis at the anastomotic site, we have developed a novel technique for distal anastomosis involving adventitial inversion employing graft telescopic insertion. METHODS: The adventitia was inverted into the aortic lumen and the anastomosis with a Dacron tube-graft was made in a telescopic method, covering the inverted adventitia. RESULTS: Five patients have undergone emergency ascending aortic replacement for aortic dissection by one surgeon using this technique. There have been no reoperations for bleeding or false aneurysm. CONCLUSION: Complete coverage of the inverted adventitia eliminated the potential risk of thrombus formation. Graft telescopic insertion lead to complete hemostasis.  (+info)

Ultrasound-guided percutaneous delivery of tissue-engineered endothelial cells to the adventitia of stented arteries controls the response to vascular injury in a porcine model. (5/30)

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Fluid flow along venous adventitia in rabbits: is it a potential drainage system complementary to vascular circulations? (6/30)

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Dynamic T cell-APC interactions sustain chronic inflammation in atherosclerosis. (7/30)

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Single-walled carbon nanotubes promote rat vascular adventitial fibroblasts to transform into myofibroblasts by SM22-alpha expression. (8/30)

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Figure 2: Oncostatin M and TLR-4 Ligand Synergize to Induce MCP-1, IL-6, and VEGF in Human Aortic Adventitial Fibroblasts and Smooth Muscle Cells
In order to find the difference between human lung tissue-derived fibroblasts and human vascular adventitial fibroblasts for enhancing tumor formation ablity of human lung adenocarcinoma cell line A549, we found that human vascular adventitial fibroblasts enhance A549 tumor formation in vivo compared to human lung tissue-derived fibroblasts. To find the responsible genes for this phenomena, we used microarray analysis to find the expression difference between lung tissue-derived fibroblasts and vascular adventitial fibroblas Cultured human lung tissue-derived fibroblasts and human vascular adventitial fibroblasts were analyzed in replicates.. ...
Adventitial fibroblasts have been described to exhibit the earliest, most dramatic, and most sustained proliferative, fibrotic, and inflammatory responses to vascular stress and thus to play a key role in PH process.4,9,10,44,45 Failure of activated fibroblasts to deactivate contributes to chronic inflammatory and fibrotic diseases.9,11 The mechanisms contributing to sustained activation of vascular adventitial fibroblasts in PH are yet to be defined. Numerous studies have shown that miRNAs are pivotal in the gene regulation process, playing important roles in controlling development, tissue-specific cell differentiation, cell proliferation and migration, apoptosis, and stress responses.22,23,46,47 However, it was previously not known whether changes in miRNA expression directly control the activated phenotype of pulmonary fibroblasts in PH.. The present study demonstrates an important role for miR-124 and its direct downstream target, the alternative splicing factor PTBP1, in the generation of ...
CMV is thought to be a key pathogen involved in the pathogenesis of TV in human allografts. To evaluate the direct effect of CMV infection on vascular biology, we used a rat model in which aortic allografts were infected ex vivo with RCMV prior to transplantation. We chose 2 time points after transplantation to investigate the development of TV, 2 weeks that represented the early phase of TV in rats; and 8 weeks, when TV was fully developed. We found that RCMV influenced vascular remodeling by increased apoptosis of SM-α-actin positive cells in the media layer, decreased extracellular matrix deposits and increased intimal hyperplasia. Moreover, RCMV induced a strong infiltration of CD68-positive macrophages mainly in the adventitia and resulted in an increase of MCP-1 in the allograft, which resulted in migration of adventitial cells towards the intima that most likely also contributed to intimal hyperplasia.. Vessel stability is sustained by a balance between cellular proliferation and ...
Në Repartin e Emergjencës të Spitalit të Përgjithshëm - Mitrovicë, për 2 ditë kanë marr trajtim mjekësor 129 pacientë.
RESULTS: Intra- and inter-reader agreement for grading adventitial enhancement were good to excellent. IPH was present in 49% of patients and was associated with events (P = .03). Patients grouped by categories 0, 1, and 2 adventitial enhancement had increasing frequencies of events (14% category 0, 48% category 1, 65% category 2; P = .02). Events were associated with IPH (OR, 10.18; 95% CI, 1.42-72.21) and adventitial enhancement (compared with category 0: OR, 14.90, 95% CI, 0.98-225.93 for category 1; OR, 51.17, 95% CI, 3.4-469.8 for category 2) after controlling for age, sex, cardiovascular risk factors, wall thickness, and stenosis. Stenosis was not associated with events. ...
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Zie voor- en na-fotos van de resultaten van de CoolSculpting-procedure, waarop te zien is hoe dit alternatief voor chirurgische vetreductie korte metten maakt met vet dat moeilijk weg te krijgen is.
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We zijn allemaal anders. Toch moeten we het nog steeds doen met algemene voedingsadviezen. Maar dit gaat veranderen. Er is in de wetenschap een trend
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Background/Purpose: A key unmet need in the monitoring of disease activity in large vessel vasculitides (LVV), i.e., giant cell arteritis (GCA) and Takayasu arteritis (TAK), is the ability to differentiate active vasculitic disease activity from atherosclerotic damage through the use of noninvasive imaging modalities. In LVV, the inflammatory process begins at the vasa vasorum in the adventitia, with vasa vasoritis and inflammatory cell recruitment. Thickened adventitia and medial fibrosis are key features that differentiate vasculitis from atherosclerosis. A novel imaging modality that can noninvasively detect increased neovascularization and thickening in large vessels adventitia is microbubble contrast-enhanced carotid ultrasonography (CU). In animal and human studies using CU, higher densities of vasa vasorum correlated with plaque vulnerability and atherosclerosis progression. Our objective was to establish feasibility of measuring adventitial vasa vasorum density (aVVD) in LVV patients; ...
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Dit is de agenda van de NVSHA met betrekking tot deze landelijke onderwijsdagen.. Op deze pagina van de NVSHA staat een omschrijving van de huidige landelijke onderwijsdagen en de bijbehorende onderwerpen/themas.. ...
Get this from a library! Electron Paramagnetic Resonance of d Transition Metal Compounds.. [F E Mabbs; D Collison] -- Electron paramagnetic resonance (epr) spectroscopy is a sensitive and versatile method of studying paramagnets, which is finding increasing use in chemistry, biochemistry, earth and materials ...
Background: The density of vasa vasorum (VV) within atherosclerotic plaque correlates with histologic features of plaque vulnerability. Contrast enhanced ultrasound (CEUS) is a promising tool to visualize VV. We evaluated the diagnostic utility of CEUS for identifying abnormal adventitial neovascularization during atherosclerosis progression.. Methods: New Zealand rabbits (n=20) were fed a high-fat diet for 3 weeks. After 1 week on the diet, bilateral femoral artery balloon injury was used to cause accelerated atherosclerosis. Non-linear femoral CEUS (10 MHz, MI 0.3) was performed at 0, 2, 4, and 6 weeks post-injury. Peak videointensity (VI) in adventitial regions of interest was normalized to luminal VI. At each study time point, 5 rabbits were euthanized, yielding 10 arterial lesions that were sectioned for immunohistology. Adventitial VV was quantified by counting the number of microvessels and their total cross-sectional area (VVCSA).. Results: Plaque size (% lumen area) progressed over ...
Definition of adventitial neuritis. Provided by Stedmans medical dictionary and Drugs.com. Includes medical terms and definitions.
Under normal conditions, the thickness of the vascular wall is maintained at an optimal level by a fine balance between proliferation and apoptosis of the resident cell types. If this balance is disturbed in favour of proliferation, the vascular wall thickens and eventually obliterates the vessel lumen, leading to increased resistance. This structural change of the vascular bed is termed vascular remodelling 3. Pulmonary artery (PA) remodelling leads to an increase in pulmonary pressure resulting in further remodelling. Proliferation of adventitial fibroblasts increases within hours of hypoxic exposure 4, but, a few days after exposure (to hypoxia), thickening of the medial layer (hypertrophy and hyperplasia) begins to develop 5. It is known that hypertrophy of SMC makes a greater contribution than hyperplasia in the larger, more proximal arteries, whereas hyperplasia is more prevalent in the smaller resistance arteries 6, 7. Furthermore, fibroblasts migrate into the medial layer and can ...
Një vakt i tillë origjinal sigurisht do të zgjojë oreksin e mysafirëve tuaj të rinj. Për ta, ruani 200 g djathë djathë të fortë: ajo do të jetë e mjaftueshme për 6-8 servings. Mbuloni fletën e pjekjes me letër pjekje, fshini djathin me një rende dhe vendoseni në një fletë pjekjeje në formën e qarqeve, të cilat duhet të vendosen në një furrë me një temperaturë prej 200 gradë. Pas 5 minutash, djathi do të shkrihet. Merrni një gotë të zakonshme, e ktheni dhe formoni një shportë me qarqe djathi derisa djathi nuk është ftohur. Nëse dyshoni se shijoni gatimin e shpejtë për ditëlindjen e fëmijës - kjo është një opsion i favorshëm. Pas të gjitha, shporta mund të mbushet me ndonjë sallatë sipas pëlqimit tuaj, për shembull, të listuara më poshtë (për fëmijët nga 7 vjeç). ...
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Meerdere linken in de vroegere artikelen zullen vermoedelijk niet werken, maar u kan de titel dan kopiëren en plakken in het Zoek venster om zo bij het juiste artikel te komen. Ik maak ere wrek van om de artikelen vanaf 2005 terug te editen en daarin de linken te vernieuwen zodat zij terug zullen werken. Maar dit vraagt enige tijd. Daarom verzoek ik hiervoor begrip teh hebben indien u een link tegen komt die niet meer werkt ...
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TY - JOUR. T1 - Dynamic contrast-enhanced MRI in oncology: how we do it. T2 - Radiologia Medica. AU - Petralia, G.. AU - Summers, P.E.. AU - Agostini, A.. AU - Ambrosini, R.. AU - Cianci, R.. AU - Cristel, G.. AU - Calistri, L.. AU - Colagrande, S.. N1 - Export Date: 4 March 2021 CODEN: RAMEA Correspondence Address: Colagrande, S.; Struttura Complessa di Radiodiagnostica Universitaria (SOD 2), Largo Brambilla 3, Italy; email: [email protected] Chemicals/CAS: Contrast Media References: Hanahan, D., Weinberg, R., The hallmarks of cancer (2000) Cell, 144 (5), pp. 646-674; Radue, E.W., Kendall, B.E., Xenon enhancement in tumours and infarcts (1978) Neuroradiology, 16, pp. 224-227. , COI: 1:STN:280:DyaE1M7hsVykuw%3D%3D; Cherry, S.R., Carnochan, P., Babich, J.W., Serafini, F., Rowell, N.P., Watson, I.A., Quantitative in vivo measurements of tumor perfusion using rubidium-81 and positron emission tomography (1990) J Nucl Med, 31 (8), pp. 1307-1315. , COI: 1:CAS:528:DyaK3cXls1yiurg%3D, PID: ...
Pretreatment dynamic contrast-enhanced MRI biomarkers correlate with progression-free survival in primary central nervous system lymphoma Academic Article ...
acquisition acquisitions administered aetiology affected agent association body breathing cardiac challenge channel chest chronic class clear clinical coil content contrast core coronal days defined dependent diagnosis distinguish dose dynamic either enabling endothelial endpoint endpoints enhanced enrolled established evaluable evaluate evaluated evaluation exercise existing experimental explore failure female fluid fraction free gradient graph graves half healthy heart hospitals included index induced injected injector interpolated interstitial intravenous king kingdom leakage leaving lung lungs male mapping maps martin mass matrix measures measuring mechanism medicine mild minute model moderate novel parker patient patients permeability plasma population position post potential power previously primary problematic proof protocol pulmonary quantification quantifying ranging redistribution registration remains repeat repeatability repeated resolution respective respectively rest rosemary saline ...
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Dit da jow is an ancient Chinese healing remedy In response to many questions from my articles on shin conditioning and treating shin injuries, I have decided to write an article about dit da jow. Dit da jow is an ancient Chinese herbal healing...
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Die onderstaande video ontbloot die wreedaardige wyse waarop diere toegelaat word om te ly terwyl hulle aan bloedverlies sterf. Die gorrelpyp word uit die stomme diere gesny terwyl hulle nog lewe. Sensitiewe kykers moet asb nie die video oopmaak nie. Kinders moet onder geen omstandighede hieraan blootgestel word nie, omdat dit n uiters traumatiese ervaring vir die dier en die kyker meebring. Die feit dat die jaloerse Jahweh hierdie wrede metode gelas, beteken nie dat dit aanvaarbaar is
Meerdere linken in de vroegere artikelen zullen vermoedelijk niet werken, maar u kan de titel dan kopiëren en plakken in het Zoek venster om zo bij het juiste artikel te komen. Ik maak ere wrek van om de artikelen vanaf 2005 terug te editen en daarin de linken te vernieuwen zodat zij terug zullen werken. Maar dit vraagt enige tijd. Daarom verzoek ik hiervoor begrip teh hebben indien u een link tegen komt die niet meer werkt ...
Als je het land of de regio waar je winkelt verandert, kan dit van invloed zijn op bepaalde factoren, zoals de prijs en de beschikbaarheid van het product. ...
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Een prominent kenmerk van veroudering in het gezicht is het hangen van huid en subcutane weefsels. Om dit te verminderen en zo een jeugdiger uiterlijk te...
Cystic adventitial disease is a rare disorder that occurs in peripheral arteries. Calf claudication caused by compression of the popliteal artery is a typical presentation of this disease. This is a report of two cases of occluded popliteal artery decompression by percutaneous ultrasound-guided cyst aspiration. In both cases, decompression of the artery was achieved with a significant decrease in the size of adventitial cysts and restoration of flow. Both patients reported complete resolution of symptoms and no calf pain 5 years after the procedure. MR findings and resolution of symptoms in these two patients show the efficacy of percutaneous adventitial cyst aspiration in a 5-year follow-up ...
Based on our previous results implicating CaMKIIδ2 as regulator of cell migration and proliferation in cultured rat aortic VSM cells,16,18 we investigated the function of CaMKIIδ2 in the vascular response to injury. Consistent with results using an in vitro system,18 we observed a rapid and marked modulation in vascular wall CaMKII isoform expression after balloon injury in vivo, coinciding with acquisition of a migratory/proliferative phenotype in both carotid artery medial VSM and adventitial fibroblasts. Inhibiting acute upregulation of the CaMKIIδ2 isoform attenuated migration and proliferation, and functionally suppressed neointima formation and adventitial thickening. We conclude from these studies that CaMKIIδ isoforms specifically couple Ca2+ signals to regulate cell migration and proliferation, and that increased expression of these isoforms in VSM or adventitial myofibroblasts is an important component of injury induced vascular wall remodeling.. Potential sources of neointimal VSM ...
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Om te kunnen inloggen, moet je geregistreerd zijn. Registreren duurt slechts enkele minuten en daardoor krijg je ook veel meer mogelijkheden op dit forum. De beheerder kan geregistreerde gebruikers ook extra permissies verlenen. Neem voordat je inlogt eerst kennis van onze gebruikersvoorwaarden en bijhorende regels. Op het forum dienen de regels altijd te worden nageleefd.. Gebruikersvoorwaarden , Privacybeleid. ...
Een posttraumatische stressstoornis (PTSS) gaat vaak gepaard met cognitieve problemen, die door patiënten als hinderlijk kunnen worden ervaren. Neuropsychologische studies laten zien dat deze zich voornamelijk voordoen in het verbale (hippocampaal gemedieerde) declaratieve geheugen, het aandachtsdomein, het werkgeheugen en het executief functioneren, en bevestigen de impact op het dagelijks functioneren. Ook is in diverse studies aangetoond dat deze cognitieve problemen van invloed zijn op de effectiviteit van traumagerelateerde psychotherapie en werden in studies aanwijzingen gevonden dat deze cognitieve disfuncties deels omkeerbaar zijn door een succesvolle behandeling. In dit artikel wordt stilgestaan bij deze cognitieve problemen, worden inzichten hierover gedeeld vanuit de neurobiologie en worden er adviezen aangereikt voor de clinicus om rekening te houden met deze problemen tijdens de behandeling.. ...
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Zhang, L; Li, Y; Chen, M; Su, X; Yi, D; Lu, P; Zhu, D (2014). "15-LO/15-HETE mediated vascular adventitia fibrosis via p38 MAPK ... rat PA adventitia fibroblasts; Baby hamster kidney cells; and diverse types of vascular endothelial cells. These growth- ...
Two types of dowry were known-dos profectitia and dos adventitia. That dos is profectitia which was given by the father or ... All other dos is adventitia. Roman law also allowed for a species of dowry, called dos receptitia, which was given by some ...
Drosophila adventitia. *Drosophila aenicta. *Drosophila aethostoma. *Drosophila afer. *Drosophila affinidisjuncta. *Drosophila ...
The GI tract can be divided into four concentric layers in the following order: Mucosa Submucosa Muscular layer Adventitia or ... In addition, the oral cavity has adventitia. Approximately 20,000 protein coding genes are expressed in human cells and 75% of ... Retroperitoneal parts are covered with adventitia. They blend into the surrounding tissue and are fixed in position. For ...
The arteries that supply the ureters end in a network of vessels within the adventitia of the ureters. There are many ... The plexus is in the adventitia. These nerves travel in individual bundles and along small blood vessels to form the ureteric ... Beyond these layers sits an adventitia containing blood vessels, lymphatic vessels, and veins. The ureters develop from the ... the ureteric plexus that lies in the adventitia of the ureters. This plexus is formed from a number of nerve roots directly (T9 ...
The serosa is present if the tissue is within the peritoneum, and the adventitia if the tissue is retroperitoneal. When viewed ... From the inner cavity of the gut (the lumen) outwards, these are: Mucosa Submucosa Muscular layer Serosa or adventitia The ... In between the two layers of muscle lies the myenteric plexus (also called Auerbach's plexus). The serosa/adventitia are the ... The outermost layer of the gastrointestinal wall consists of several layers of connective tissue and is either adventitia or ...
1st part serosa, 2nd-4th adventitia. Normal. Normal Muscularis externa. Longitudinal and circular layers, with Auerbach's ( ...
Other more muscular parts are lined with adventitia. The digestive system is supplied by the celiac artery. The celiac artery ...
... the tunica adventitia, composed of loose collagen fibers. Innervated by barometric nerve terminals, the aortic arch is ...
Other more muscular parts are lined with adventitia. Blood supply. Arteries and veins around the pancreas and spleen ...
بَنداره (اسفنکتر) بالایی مری UES • بنداره پایینی مری LES • غدد مری Esophageal glands سروز Serosa • رویه Adventitia • لایه ...
The vaginal wall has three layers: tunica mucosa, muscularis, adventitia. When prolapse occurs, smooth fibers of the muscularis ...
Opposite to outermost (the adventitia, serosa, or the cavity's wall). Parietal (from Latin paries 'wall'): pertaining to the ...
Plantae subspontaneae vel in tempore recentiore adventitiae. Första litteraturuppgift för Sveriges vildväxande kärlväxter jämte ...
The outer layer, the adventitia, is a thin dense layer of connective tissue and it blends with loose connective tissue ... is an outer layer of connective tissue called the adventitia. Some texts list four layers by counting the two sublayers of the ... comes from muscles in the pelvic floor that are attached to the adventitia around the vagina. The lamina propria is rich in ...
As they proceed forward and in their course are joined by other capillaries, they grow larger and first take on an adventitia, ... Lymph vessels are lined by endothelial cells, and have a thin layer of smooth muscle, and adventitia that binds the lymph ... The outermost layer is the adventitia that consists of fibrous tissue. The general structure described here is seen only in ... The smallest vessels (lymphatic or lymph capillaries) lack both the muscular layer and the outer adventitia. ...
Specimens of Bipalium adventitium are characterized by a single dark dorsal stripe. They were first discovered in the US in ... B. adventitium reproduces sexually and creates egg capsules, which hatch around 3 weeks post-deposition. The egg capsules have ... Juveniles of this species, unlike B. adventitium, do not appear the same coloration as parents in their early days. Recently, ... Currently, four invasive species of Bipalium are known in the United States: B. adventitium, B. kewense, B. pennsylvanicum, and ...
"Presence of angiotensin converting enzyme in the adventitia of large blood vessels". J. Hypertens. 10 (7): 615-20. doi:10.1097/ ...
... adventitia and associated adipose tissue". The International Medical Journal. 7: 43-49. Chaldakov GN, Stankulov IS, Aloe L ( ...
The outer layer is the tunica adventitia and the thickest layer in veins. It is entirely made of connective tissue. It also ...
False diverticula (also known as "pseudodiverticula") do not involve muscular layers or adventitia. False diverticula, in the ... including muscularis propria and adventitia, such as Meckel's diverticulum. ...
The outside of the bladder is protected by a serous membrane called adventitia. Vertical section of bladder wall Layers of the ... and an outer adventitia. The inner wall of the bladder is called urothelium, a type of transitional epithelium formed by three ...
Adventitia and serosaEdit. Main articles: Serous membrane and Adventitia. The outermost layer of the gastrointestinal tract ... In addition, the oral cavity has adventitia. Gene and protein expressionEdit. Approximately 20,000 protein coding genes are ... Retroperitoneal parts are covered with adventitia. They blend into the surrounding tissue and are fixed in position. For ...
... in describing the external coat or tunica adventitia of an artery, Gray says: "...consists mainly of fine and closely felted ...
"Computer vision analysis of collagen fiber bundles in the adventitia of human blood vessels". Studies in Health Technology and ...
May 2004). "Abundant progenitor cells in the adventitia contribute to atherosclerosis of vein grafts in ApoE-deficient mice". ...
The pubovesical ligament is the continuation of the detrusor muscle and the adventitia surrounding the urinary bladder. It ...
... and adventitia. Atheroma and changes in the artery wall usually result in small aneurysms (enlargements) just large enough to ...
Like other structures of the gastrointestinal tract, the duodenum has a mucosa, submucosa, muscularis externa, and adventitia. ...
Most AAA are true aneurysms that involve all three layers (tunica intima, tunica media and tunica adventitia). The prevalence ...
Adventitia definition, the external covering of an organ or other structure, derived from connective tissue, especially the ... adventitia. in Medicine. adventitia. [ăd′vĕn-tĭsh′ə]. n.. *The outermost membranous covering of an organ or structure, ... adventitia. Historical Examples. of adventitia. *. Up to the third decade there is only a strengthening of the media and ... The adventitia varies much in thickness, being better developed in the medium-sized than in the large arteries. ...
... it is covered by adventitia. The connective tissue of the gallbladder is covered by adventitia where the gallbladder bounds the ... The adventitia, (advɛnˈtɪʃə) is the outer layer of fibrous connective tissue surrounding an organ. The outer layer of ... In the abdomen, whether an organ is covered in adventitia or serosa depends upon whether it is peritoneal or retroperitoneal: ... the muscular layer is instead bounded by adventitia. The muscular layer of the duodenum is bounded by both tissue types. ...
Bipalium adventitium is known to prey on earthworms. In order to catch its prey, it follows a chemical trail given off by the ... Bipalium adventitium is believed to have been introduced in the last century to the United States from Asia. It is believed ... Bipalium adventitium is a land planarian in the subfamily Bipaliinae. It has been accidentally introduced in the United States ... Most adult individuals of B. adventitium are 5-8 cm (2.0-3.1 in) in length. The head is expanded and fan-shaped, being easily ...
adventitia at eMedicine Dictionary. *Organology at UC Davis Digestive/mammal/system1/system10 - "Mammal, whole system (LM, Low ... 4. Adventitia. 5. Striated muscle. 6. Striated and smooth. 7. Smooth muscle. 8. Lamina muscularis mucosae. 9. Esophageal glands ... Adventitia is the outermost connective tissue covering of any organ, vessel, or other structure. ... In the abdomen, whether an organ is covered in adventitia or serosa depends upon whether it is peritoneal or retroperitoneal: * ...
What is membrana adventitia? Meaning of membrana adventitia medical term. What does membrana adventitia mean? ... Looking for online definition of membrana adventitia in the Medical Dictionary? membrana adventitia explanation free. ... Synonym(s): tunica adventitia [TA], membrana adventitia (1) [L. adventicius, coming from abroad, foreign, fr. ad, to + venio, ... membrana adventitia. (1) Tunica externa (see there); tunica adventitia [NA6].. (2) Capsular decidua; decidua capsularis [[NE3 ...
In model rats, hyperplasia in the intima was mild but obvious in the adventitia; CRP heightened; expressions of MCP-1, CD68, ... Therefore, reducing inflammation reaction and connexins expression in adventitia may become a new target to prevent vascular ... obviously diminished the expressions of CD68 and Cx43 in the adventitia, and reduced CRP but did not lower MCP-1. These results ... The area of adventitia 7 days after balloon injury. with sham group, . with model group, . ...
Elastic elements in the media and adventitia of human intracranial extracerebral arteries.. F T Mérei, F Gallyas, Z Horváth ... We find that the media and adventitia of adult human cerebral arteries contain elastic fibers forming a dense, coherent network ... Elastic elements in the media and adventitia of human intracranial extracerebral arteries. ... Elastic elements in the media and adventitia of human intracranial extracerebral arteries. ...
NE had no effect on expression of these proteins in day-4 injured adventitia. Adventitia for day-12 injured aorta was not ... and in adventitia by 12±3%, 49±5%, and 23±5% (Figure 3A). The increased sensitivity of IM and adventitia to NE remained evident ... In adventitia of uninjured aorta, there was a trend toward similar but smaller effects on protein synthesis and content (Figure ... In adventitia of day-12 aorta, DNA returned to uninjured levels but protein remained reduced (Figure 2A), suggesting that ...
... and periarterial adipose tissue intima media adventitia index in morbidly obese patients undergoing bariatric surgery. Justyna ... and periarterial adipose tissue intima media adventitia index in morbidly obese patients undergoing bariatric surgery. ... and periarterial adipose tissue intima media adventitia index in morbidly obese patients undergoing bariatric surgery. ... and periarterial adipose tissue intima media adventitia index in morbidly obese patients undergoing bariatric surgery". ...
Sim, M.K. (1990). Angiotensin converting enzyme in the endothelium and smooth muscle cum adventitia of the normo- and ... Angiotensin converting enzyme in the endothelium and smooth muscle cum adventitia of the normo- and hypertensive rat aorta. ...
... the external covering of an organ or other structure, derived from connective tissue, especially the ... Definithing > Dictionary > a > Adventitia. Adventitia. the external covering of an organ or other structure, derived from ... adventitia ad·ven·ti·tia (ādvěn-tĭshə, -vən-). n.. The outermost membranous covering of an organ or structure, especially the ... Disclaimer: Adventitia definition / meaning should not be considered complete, up to date, and is not intended to be used in ...
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Adventitia Scissors, 15cm long Round Handle 8mm diameter, Straight Serrated Blade 9mm ...
Adventitia. Autonomic nerves located in the tunica adventitia have connections with these subendothelial structures via ... Within the adventitia, loose connective tissue surrounds autonomic nerve fibers, and all vessel wall structures are enclosed by ... A rete vasorum in the adventitia is permeable to large proteins, allowing ingress or exchange with the CSF in the subarachnoid ... Cerebrospinal fluid may nourish cerebral vessels through pathways in the adventitia that may be analogous to systemic vasa ...
Adventitia of abdominal part of ureter. C0736511 View more…. Muscles and fasciae of abdomen by Henry Gray. Part 1 Audio book. ...
The investigator hypothesizes that the adventitia which is enriched in fibroblasts, plays a major role in vascular lesion ... Adventitia and Vascular Lesion Formation. Wilcox, Josiah N. / Emory University. $306,584. NIH 1999. R01 HL. Adventitia and ... by a reduction of adventitia blood supply by the vasa vasorum caused by balloon inflation resulting in adventitia ischemia. His ... Adventitia and Vascular Lesion Formation Wilcox, Josiah N. Emory University, Atlanta, GA, United States ...
Adventitia vs Serosa Serosa is different from adventitia because serosa is for lubrication where as adventitia is to bind ... What is Adventitia?. Adventitia is a connective tissue. It is the outermost connective tissue layer that surrounds any ... What is the difference between Adventitia and Serosa?. • Serosa secretes serous fluid where as adventitia does not secrete a ... Filed Under: Biology Tagged With: Adventitia, connective tissue, epicardium, pericardium, perimetrium, serosa, serous, serous ...
Title browse > Conferences > Proceedings of 11th International Vascular Neuroef... > Role of adventitia in vascular oxidative ... Our group has shown that the adventitia is also an important site of suoeroxide anion production in normal rat aorta and NADPH ...
Adventitia. *. On sepsis and defining words (1 October, 1993) Free Cory Franklin ...
Adventitia. *. Surgery at the Brompton Hospital in 1932-3 (1 July, 1992) Free Guy Scadding ...
Characterization of the arterial adventitia as a Sonic Hedgehog responsive niche. 2019-04-11. Public. Press to Select an action ... While formerly viewed as merely connective tissue, the emerging view of the arterial adventitia is that of a complex and ... Previously, our lab has identified a domain of Sonic Hedgehog (Shh) signaling restricted to the adventitia. This domain is ... Characterization of the Arterial Adventitia as a Sonic Hedgehog Responsive Niche Public Deposited ...
The adventitia and the media vasa vasorum. Pedro R. Moreno of Mount Sinai Medical Center provided an overview of work on the ... Moreno studied the interactions between the tunica media and the adventitia in advanced human atherosclerosis. His observations ...
What Is the Difference Between Adventitia and Serosa?. A: The exterior layer of the gastrointestinal tract is the adventitia ...
Adventitia. The adventitia consists of several layers of epithelia.. When the adventitia is facing the mesentery or peritoneal ... fold, the adventitia is covered by a mesothelium supported by a thin connective tissue layer, together forming a serosa, or ...
Adventitia. The adventitia consists of several layers of epithelia. When the adventitia is facing the mesentery or peritoneal ... Adventitia or serosa Mucosa. The mucosa is the innermost layer of the gastrointestinal tract, surrounding the lumen, or space ... fold, the adventitia is covered by a mesothelium supported by a thin connective tissue layer, together forming a serosa, or ...
Adventitia. The adventitia consists of several layers of epithelia.. When the adventitia is facing the mesentery or peritoneal ... Adventitia. The adventitia consists of several layers of epithelia. When the adventitia is facing the mesentery or peritoneal ... Adventitia or serosa Mucosa. The mucosa is the innermost layer of the gastrointestinal tract that is surrounding the lumen, or ... fold, the adventitia is covered by a mesothelium supported by a thin connective tissue layer, together forming a serosa, or ...
Adventitia is the outermost connective tissue covering of an organ, vessel, or other structure.[1] It is also called the tunica ... In the abdomen, whether an organ is covered in adventitia or serosa depends upon whether it is peritoneal or retroperitoneal: * ... The connective tissue of the gallbladder is covered by adventitia where the gallbladder bounds the liver, but by serosa for the ... retroperitoneal organs are covered in adventitia (loose connective tissue) In the gastrointestinal tract, the muscularis ...
ADVENTITIA OR SEROSA. Composition: *thick layer of dense connective tissue with large blood vessels, extensive lymphatic ...
The addition of a vasa vasorum to the tissue-engineered adventitia did not influence the burst pressure of these constructs. ... Tissue-Engineered Vascular Adventitia with Vasa Vasorum Improves Graft Integration and Vascularization Through Inosculation. ... Tissue-Engineered Vascular Adventitia with Vasa Vasorum Improves Graft Integration and Vascularization Through Inosculation ... Characterization of the mechanical properties of both control and vascularized adventitia demonstrated that the ultimate ...
N, neointima; M, media; A, adventitia. (A and B) H&E staining. (Scale bar, 20 μm.) (C and D) Movat Pentachrome staining. (Scale ... L, lumen; N, neointima; M, media; A, adventitia; IEL, internal elastic lamina; EEL, external elastic lamina. ...
  • Therefore, reducing inflammation reaction and connexins expression in adventitia may become a new target to prevent vascular remodeling. (hindawi.com)
  • For a long time, vascular smooth muscle cells (VSMCs) in the media have been regarded as a central link and the adventitia has been known to play only supportive functions [ 1 ]. (hindawi.com)
  • However, the adventitia is an essential regulator of vascular wall structure and function. (hindawi.com)
  • Adventitial fibroblasts (AFs, the major component of the adventitia) are activated and transfer into myofibroblasts, proliferate, and migrate to media and intima to participate in the progression of vascular remodeling [ 2 , 3 ]. (hindawi.com)
  • The investigator hypothesizes that the adventitia which is enriched in fibroblasts, plays a major role in vascular lesion formation after angioplasty and during the atherosclerosis process. (grantome.com)
  • Finally, the Principal Investigator will determine the role of adventitia inflammation which is associated with angioplasty in the early growth responses in the vascular wall after injury. (grantome.com)
  • While formerly viewed as merely connective tissue, the emerging view of the arterial adventitia is that of a complex and organized vascular progenitor cell niche. (unc.edu)
  • Thus, we characterize the adventitia as a Shh responsive vascular niche. (unc.edu)
  • Such a vascularization could play an important role in graft perfusion and host integration of tissue-engineered vascular adventitia. (ulaval.ca)
  • Virtually all arteries are surrounded by amounts of perivascular adipose tissue (PVAT), which is juxtaposed to the vascular adventitia. (diabetesjournals.org)
  • Whether the adventitia component of blood vessels directly participates in the regulation of vascular tone remains to be demonstrated. (ulaval.ca)
  • To investigate the role of the adventitia in the modulation of vascular tone, this tissue-engineering method was used to produce three vascular constructs from cells explanted and proliferated from donor vessel tunicae 1) an adventitia + a media, or only 2) an adventitia, or 3) a media. (ulaval.ca)
  • The middle tunica, termed media, is mainly composed of vascular smooth muscle cells (VSMCs) in an extracellular matrix (ECM) and corresponds to the muscular portion of the blood vessel, whereas the tunica adventitia is mainly composed of vascular fibroblasts (VFs) and ECM. (ulaval.ca)
  • The first vascular construct was composed of only an adventitia (TEVA), a second vascular construct contained only a media (TEVM), and the third contained a media and an adventitia (TEVMA). (ulaval.ca)
  • The spillover of cytokines and fatty acids into the vascular adventitia, which is facilitated by the lack of a connective tissue barrier between PVAT and the adjacent artery, promotes arterial inflammation that may augment atherosclerosis and increase risk of plaque rupture [12]. (tak-700.info)
  • Adventitial inflammation and the pro-inflammatory phenotype of PVAT The location of PVAT, abutting the nearby adventitia of blood R547 inhibitor vessels without a physical anatomical barrier, facilitates its ability to govern the focal vascular milieu via paracrine and vasocrine routes [1,6,8]. (tak-700.info)
  • For instance, in hyperlipidemic atherosclerosis-prone apolipoprotein E (ApoE)-lacking mice, the main site of vascular inflammatory cell accumulation was reported to be the adventitia as opposed to the intima, and in atherosclerotic human being aorta, inflammatory cells were noticed to become clustered in PVAT in the adventitial margin densely, suggesting that PVAT gets the potential to foster vascular inflammation [8,17]. (tak-700.info)
  • The aim of the present study was to investigate the effect of removal of the adventitia on vascular remodeling and vasoconstriction of the carotid artery in New Zealand rabbit . (bvsalud.org)
  • Removal of the adventitia caused a remarkable proliferation of the vascular media and formed the neointima . (bvsalud.org)
  • Adventitia removal promoted the neointima formation and decreased vasoconstriction of the carotid artery , indicating that the adventitia is involved in the regulation of vascular remodeling and vasoconstriction . (bvsalud.org)
  • Generation of Cardiomyocytes From Vascular Adventitia-Resident Stem Cells. (uibk.ac.at)
  • In the abdomen, whether an organ is covered in adventitia or serosa depends upon whether it is peritoneal or retroperitoneal: intraperitoneal organs are covered in serosa (a layer of mesothelium, the visceral peritoneum) retroperitoneal organs are covered in adventitia (loose connective tissue) In the gastrointestinal tract, the muscular layer is bounded in most cases by serosa. (wikipedia.org)
  • Generally, if it is a part of the digestive tract that is free to move, it is covered by serosa, and if it is relatively rigidly fixed, it is covered by adventitia. (wikipedia.org)
  • The connective tissue of the gallbladder is covered by adventitia where the gallbladder bounds the liver, but by serosa for the rest of its surface. (wikipedia.org)
  • Serosa is different from adventitia because serosa is for lubrication where as adventitia is to bind structures together. (differencebetween.com)
  • In the abdomen, surrounding an organ with serosa or adventitia depends on whether the organ is peritoneal or retroperitoneal. (differencebetween.com)
  • Peritoneal organs are surrounded by serosa, and retroperitoneal organs are surrounded by adventitia. (differencebetween.com)
  • In the duodenum, the muscularis externa is bound by both adventitia and serosa. (differencebetween.com)
  • Serosa secretes serous fluid where as adventitia does not secrete a fluid. (differencebetween.com)
  • Main function of adventitia is to bind structures whereas, the main function of serosa is lubrication. (differencebetween.com)
  • The exterior layer of the gastrointestinal tract is the adventitia where the tract goes through the body wall, but it is the serosa where the tract goes th. (reference.com)
  • In this video, Dr Mike explores the differences between serosa and adventitia within GIT. (digitalpodcast.com)
  • However, large- and medium-sized arteries, where usually atherosclerotic lesions develop, are consistently surrounded by periadventitial adipose tissue (PAAT), we recently designated tunica adiposa (in brief, adiposa like intima, media, and adventitia). (frontiersin.org)
  • The adventitia, (advɛnˈtɪʃə) is the outer layer of fibrous connective tissue surrounding an organ. (wikipedia.org)
  • The outer layer of connective tissue that surrounds an artery, or vein - the tunica externa, is also called the tunica adventitia. (wikipedia.org)
  • The outer layer of a blood vessel consists of collagen and elastin and is known as the tunica adventitia. (medicalnewstoday.com)
  • and an outer layer, or tunica adventitia . (britannica.com)
  • The outer layer (tunica adventitia) consists chiefly of connective tissue and is the thickest layer of the vein. (britannica.com)
  • As AAAs progress, abundant numbers of macrophages accumulate in the adventitia [ 9 ]. (clinsci.org)
  • However, at the oral cavity, thoracic esophagus, ascending colon, descending colon and the rectum, the muscular layer is instead bounded by adventitia. (wikipedia.org)
  • These findings define cytokine profiles in the A-II infusion model and demonstrate that IL-6, produced by activated macrophages and fibroblasts in the adventitia, induces the Jak-STAT3 pathway during early A-II-induced atherosclerosis. (utmb.edu)
  • Intima-media and adventitia were separated and DNA content, protein synthesis, and protein content measured. (ahajournals.org)
  • In uninjured aorta, NE increased DNA and protein content similarly in adventitia, and increased only protein content in intima-media, suggesting AFB proliferation and SMC hypertrophy. (ahajournals.org)
  • Milutinović A, Šuput D, Zorc-Pleskovič R. Pathogenesis of atherosclerosis in the tunica intima, media, and adventitia of coronary arteries: An updated review. (bjbms.org)
  • intima, media, and adventitia. (frontiersin.org)
  • We studied whether iNOS is expressed after collar-induced intimal thickening, and if so, its localization (intima, media, and/or adventitia) and whether collar-induced intimal thickening is affected by local treatment with the selective iNOS inhibitor l - N 6 -(1-iminoethyl)-lysine-HCl (L-NIL). (ahajournals.org)
  • Coordinates ρ = 0 and ρ = 1 correspond to the intima-media and media-adventitia interfaces, respectively. (royalsocietypublishing.org)
  • Terminologia Anatomica lists adventitia (tunica adventitia) of the following organs: blood vessels, ductus deferens, esophagus, renal pelvis, seminal glands, and ureters. (thefreedictionary.com)
  • Or the tumour has grown into the layer of connective tissue that supports and covers the outside of the esophagus (adventitia). (cancer.ca)
  • The adventitia varies much in thickness, being better developed in the medium-sized than in the large arteries. (dictionary.com)
  • Elastic elements in the media and adventitia of human intracranial extracerebral arteries. (ahajournals.org)
  • We find that the media and adventitia of adult human cerebral arteries contain elastic fibers forming a dense, coherent network, similar to that found in muscular arteries of the same size in other organs. (ahajournals.org)
  • Features of atherosclerosis in the tunica adventitia of coronary and carotid arteries in a black kenyan population. (ac.ke)
  • Ogeng'o J, Ongeti K, Obimbo M, Olabu B, Mwachaka P. "Features of atherosclerosis in the tunica adventitia of coronary and carotid arteries in a black kenyan population. (ac.ke)
  • This study aimed at describing the features of atherosclerosis in the tunica adventitia of two of the commonly afflicted arteries, namely, left anterior descending coronary and common carotid in black Kenyans. (ac.ke)
  • Features of atherosclerosis were present in the tunica adventitia of 14.8% of left anterior descending arteries and 11.1% of common carotid arteries. (ac.ke)
  • In the left anterior descending and common carotid arteries, 6.5% and 3.7% of cases, respectively, the tunica adventitia thickened without intimal hyperplasia. (ac.ke)
  • Features of atherosclerosis occur in the tunica adventitia of coronary and carotid arteries in over 10% of the black Kenyans studied. (ac.ke)
  • In vehicle-treated injured arteries, mast cell count in the adventitia showed a great increase, which was completely prevented by the tranilast treatment. (ahajournals.org)
  • Furthermore, collars were connected to osmotic minipumps for local delivery (5 μL · h −1 , 14 days, n=12) of saline or the iNOS inhibitor l - N 6 -(1-iminoethyl)-lysine-HCl (L-NIL, 10 mmol/L). In the adventitia and the periadventitial granulation tissue of collared arteries, iNOS-positive macrophages and T lymphocytes were present from 18 hours onward. (ahajournals.org)
  • Meanwhile myofibroblasts release various proinflammatory cytokines, for instance, MCP-1, recruiting macrophages and neutrophils to infiltrate into the adventitia [ 10 , 11 ]. (hindawi.com)
  • The infiltration of inflammatory cells, including macrophages, lymphocytes, and mast cells, is mainly observed in the tunica adventitia of human aneurismal tissues ( 18 ). (diabetesjournals.org)
  • Histologic changes which occur in the tunica adventitia during initiation, progression, and complications of atherosclerosis are seldom reported. (ac.ke)
  • Tunica adventitia should therefore be prioritized in evaluation for atherosclerosis, in individuals at risk. (ac.ke)
  • During the development of atherosclerosis, the microvessels from the tunica adventitia or from the lumen may penetrate thickened media to provide nutrition and oxygenation. (bjbms.org)
  • Recent data indicate that the major responses immediately after angioplasty are inflammation of the adventitia and proliferation of adventitial myofibroblasts. (grantome.com)
  • These studies will determine the extent of adventitia myofibroblast migration into the restenotic lesion, the extent of the adventitia ischemia caused by balloon inflation, and its effects on fibrosis and inflammation in the adventitia. (grantome.com)
  • Increased cholesterol monohydrate area, internal elastic lamina area, positive remodeling, fibrous cap inflammation, adventitia breakdown, and inflammation were independent predictors of plaque disruption. (nih.gov)
  • The protective effect of tanshinoneⅡA is probably mediated through reducing the number and activation percentage of mast cells, decreasing the release of inflammatory cytokines and inflammation of carotid artery in adventitia. (bvsalud.org)
  • Adventitia is the outermost connective tissue covering of any organ , vessel , or other structure. (wikidoc.org)
  • Of or relating to the adventitia of an organ or blood vessel. (definithing.com)
  • Sometimes it is also referred to as the tunica externa especially when it is the adventitia of artery. (differencebetween.com)
  • [ 1 ] It is also called the tunica adventitia [ 1 ] or the tunica externa. (omicsgroup.org)
  • Adventitia of carotid artery was removed mechanically. (bvsalud.org)
  • The histology , morphology and reactivity of the carotid artery was observed by immunohistochemistry and measurement of carotid ring tension immediately, 1 week and 2 weeks after removal of the adventitia . (bvsalud.org)
  • Local IL-6 production was confirmed by in situ mRNA hybridization and immunostaining, where the most abundant IL-6 was found in the aortic adventitia, with lesser production by the medial and intimal layers. (utmb.edu)
  • Experimental data from [ 58 ] on the compliance properties of thoracic aortic segments (where the tunica adventitia has been excised) are reported as benchmark for the homeostatic case (S0). (royalsocietypublishing.org)
  • The adventitia, media, and intima of the aortic wall. (nih.gov)
  • Yiqihuoxuejiedu formula relieved intimal hyperplasia and adventitial area, obviously diminished the expressions of CD68 and Cx43 in the adventitia, and reduced CRP but did not lower MCP-1. (hindawi.com)
  • The lack of appropriate technical procedures to separate the adventitia tunica from the other components of a native blood vessel (stripping) has prevented direct investigations on the possible role of that layer in the regulation of vasomotor tone. (ulaval.ca)
  • The degree of inflammatory cell infiltration into the adventitia, which can lead to the formation of tertiary lymphoid organs, correlates with the severity of atherosclerotic plaques. (bjbms.org)
  • In addition to the immune response occurring in the spleen and lymph nodes, it has been shown that lymphoid neogenesis takes place in the adventitia of atherosclerotic vessels, leading to the formation of tertiary lymphoid organs where an adaptive immune response can be mounted. (springer.com)
  • For example, the connective tissue that surrounds an artery is called the tunica adventitia because it is considered extraneous to the artery. (wikidoc.org)
  • Characterization of the mechanical properties of both control and vascularized adventitia demonstrated that the ultimate tensile strength, modulus, and failure strain were in the same order of magnitude of a pig coronary artery. (ulaval.ca)
  • As depicted in Figure 1 , the perivascular nerves are positioned at the media-adventitia border. (frontiersin.org)
  • The addition of a vasa vasorum to the tissue-engineered adventitia did not influence the burst pressure of these constructs. (ulaval.ca)
  • Activation of downstream IL-6 signaling mediated by the Jak-STAT3 pathway was demonstrated by inducible phospho-Tyr 705 -STAT3 formation in the adventitia and endothelium (of IL-6 +/+ mice only). (utmb.edu)
  • The adventitia contracted to endothelin-1, -2, whereas the media and the media+adventitia contracted to all three endothelins. (ulaval.ca)
  • Endothelin-induced contraction of the adventitia was dependent on ETA receptors, whereas that of the media and the adventitia+media was ETA and ETB receptor-dependent. (ulaval.ca)
  • No damage of intima and media was observed after removing the adventitia . (bvsalud.org)
  • 9 10 The adventitia is a layered collagen fabric with a strong dominance of circumferential fibers adjacent to the media and a wide range of orientations in the outer layers. (ahajournals.org)
  • which separates the tunica media from the tunica adventitia. (coursera.org)
  • Additional data from Dr. Wilcox's laboratory indicate that adventitia myofibroblasts have the potential to migrate into the neointima after angioplasty and contribute to the mass of the restenotic lesion. (grantome.com)
  • The hypothesis is that these responses are stimulated, in part, by a reduction of adventitia blood supply by the vasa vasorum caused by balloon inflation resulting in adventitia ischemia. (grantome.com)
  • Thirdly, the hypothesis that angioplasty causes a reduction of adventitia blood flow resulting in ischemia will be tested. (grantome.com)
  • The present study suggests that the adventitia of a blood vessel could play a greater role than expected in the modulation of blood vessel tone. (ulaval.ca)
  • Nonetheless, whether the adventitia can directly participate in the regulation of vasomotor tone of blood vessels still remains to be demonstrated. (ulaval.ca)
  • The tunica adventitia anchors blood vessels to surrounding structures. (ideafit.com)