Adult Stem Cells: Cells with high proliferative and self renewal capacities derived from adults.Stem Cells: Relatively undifferentiated cells that retain the ability to divide and proliferate throughout postnatal life to provide progenitor cells that can differentiate into specialized cells.Multipotent Stem Cells: Specialized stem cells that are committed to give rise to cells that have a particular function; examples are MYOBLASTS; MYELOID PROGENITOR CELLS; and skin stem cells. (Stem Cells: A Primer [Internet]. Bethesda (MD): National Institutes of Health (US); 2000 May [cited 2002 Apr 5]. Available from: Differentiation: Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.Stem Cell Transplantation: The transfer of STEM CELLS from one individual to another within the same species (TRANSPLANTATION, HOMOLOGOUS) or between species (XENOTRANSPLANTATION), or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). The source and location of the stem cells determines their potency or pluripotency to differentiate into various cell types.Hematopoietic Stem Cells: Progenitor cells from which all blood cells derive.Embryonic Stem Cells: Cells derived from the BLASTOCYST INNER CELL MASS which forms before implantation in the uterine wall. They retain the ability to divide, proliferate and provide progenitor cells that can differentiate into specialized cells.Pluripotent Stem Cells: Cells that can give rise to cells of the three different GERM LAYERS.Cell Lineage: The developmental history of specific differentiated cell types as traced back to the original STEM CELLS in the embryo.Mesenchymal Stromal Cells: Bone-marrow-derived, non-hematopoietic cells that support HEMATOPOETIC STEM CELLS. They have also been isolated from other organs and tissues such as UMBILICAL CORD BLOOD, umbilical vein subendothelium, and WHARTON JELLY. These cells are considered to be a source of multipotent stem cells because they include subpopulations of mesenchymal stem cells.Tissue Engineering: Generating tissue in vitro for clinical applications, such as replacing wounded tissues or impaired organs. The use of TISSUE SCAFFOLDING enables the generation of complex multi-layered tissues and tissue structures.Nuclear Reprogramming: The process that reverts CELL NUCLEI of fully differentiated somatic cells to a pluripotent or totipotent state. This process can be achieved to a certain extent by NUCLEAR TRANSFER TECHNIQUES, such as fusing somatic cell nuclei with enucleated pluripotent embryonic stem cells or enucleated totipotent oocytes. GENE EXPRESSION PROFILING of the fused hybrid cells is used to determine the degree of reprogramming. Dramatic results of nuclear reprogramming include the generation of cloned mammals, such as Dolly the sheep in 1997.Induced Pluripotent Stem Cells: Cells from adult organisms that have been reprogrammed into a pluripotential state similar to that of EMBRYONIC STEM CELLS.Fagopyrum: A plant genus of the family POLYGONACEAE that is used as an EDIBLE GRAIN. Although the seeds are used as cereal, the plant is not one of the cereal grasses (POACEAE).Medical Staff: Professional medical personnel who provide care to patients in an organized facility, institution or agency.Stem Cell Research: Experimentation on STEM CELLS and on the use of stem cells.Cell- and Tissue-Based Therapy: Therapies that involve the TRANSPLANTATION of CELLS or TISSUES developed for the purpose of restoring the function of diseased or dysfunctional cells or tissues.Mesenchymal Stem Cell Transplantation: Transfer of MESENCHYMAL STEM CELLS between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS).Regeneration: The physiological renewal, repair, or replacement of tissue.Embryo Research: Experimentation on, or using the organs or tissues from, a human or other mammalian conceptus during the prenatal stage of development that is characterized by rapid morphological changes and the differentiation of basic structures. In humans, this includes the period from the time of fertilization to the end of the eighth week after fertilization.Newspapers: Publications printed and distributed daily, weekly, or at some other regular and usually short interval, containing news, articles of opinion (as editorials and letters), features, advertising, and announcements of current interest. (Webster's 3d ed)Leasing, Property: Contractual arrangement between the lessor (owner) and the lessee in which the use of equipment or facilities is granted to the lessee for a period of time and at a specified rate.Neural Stem Cells: Self-renewing cells that generate the main phenotypes of the nervous system in both the embryo and adult. Neural stem cells are precursors to both NEURONS and NEUROGLIA.Mass Media: Instruments or technological means of communication that reach large numbers of people with a common message: press, radio, television, etc.MarylandBone Marrow: The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.Bone Marrow Cells: Cells contained in the bone marrow including fat cells (see ADIPOCYTES); STROMAL CELLS; MEGAKARYOCYTES; and the immediate precursors of most blood cells.Bone Marrow Transplantation: The transference of BONE MARROW from one human or animal to another for a variety of purposes including HEMATOPOIETIC STEM CELL TRANSPLANTATION or MESENCHYMAL STEM CELL TRANSPLANTATION.Bone and Bones: A specialized CONNECTIVE TISSUE that is the main constituent of the SKELETON. The principle cellular component of bone is comprised of OSTEOBLASTS; OSTEOCYTES; and OSTEOCLASTS, while FIBRILLAR COLLAGENS and hydroxyapatite crystals form the BONE MATRIX.DNA Repair: The reconstruction of a continuous two-stranded DNA molecule without mismatch from a molecule which contained damaged regions. The major repair mechanisms are excision repair, in which defective regions in one strand are excised and resynthesized using the complementary base pairing information in the intact strand; photoreactivation repair, in which the lethal and mutagenic effects of ultraviolet light are eliminated; and post-replication repair, in which the primary lesions are not repaired, but the gaps in one daughter duplex are filled in by incorporation of portions of the other (undamaged) daughter duplex. Excision repair and post-replication repair are sometimes referred to as "dark repair" because they do not require light.Journalism, Medical: The collection, writing, and editing of current interest material on topics related to biomedicine for presentation through the mass media, including newspapers, magazines, radio, or television, usually for a public audience such as health care consumers.Psychiatry: The medical science that deals with the origin, diagnosis, prevention, and treatment of mental disorders.Library Services: Services offered to the library user. They include reference and circulation.Cardiology: The study of the heart, its physiology, and its functions.Internet: A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.Neurosciences: The scientific disciplines concerned with the embryology, anatomy, physiology, biochemistry, pharmacology, etc., of the nervous system.Russia (Pre-1917)
(1/1106) Adult neural stem/progenitor cells in neurodegenerative repair.

Although the mammalian brain has long been thought to be entirely postmitotic, the recent discovery has confirmed an existence of neural stem or progenitor cells in various regions of the adult mammalian brain. Like embryonic stem cells, adult neural progenitor cells possess the capacity of self-renewal and differentiation potential for neurogenesis or gliogenesis. In addition to the subventricular zone and hippocampus where active cell division naturally occurs, adult neural progenitors with neurogenic potential exist in the striatum and the vicinity of dopaminergic neurons in the substantia nigra. Normally, progenitors in those regions proliferate at a low level, and most proliferated cells remain uncommitted. In response to the selective lesion of nigrostriatal dopaminergic pathway by the neurotoxins, such as 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) or 6-hydroxydopamine, progenitors in the injured areas markedly increase their proliferation rate. Depending upon the magnitude and kinetics of the lesion, neurogenesis and gliogenesis were induced in the lesion sites at varying extents. A large number of growth and neurotrophic factors influence proliferation and/or differentiation of progenitor cells under normal and lesioned conditions. Some factors (epidermal and basic fibroblast growth factors and brain-derived neurotrophic factor) are facilitatory, while others (usually bone morphogenetic proteins) are inhibitory, for controlling division and fate of neuronal or glial progenitors. Expression of endogenous factors and their respective receptors in existing and newborn cells are also subject to be altered by the lesion. These genomic responses are considered to be important elements for the formation of a local molecular niche for a given phenotypic cell regeneration. Taken together, adult neural progenitor cells in the nigrostriatal dopaminergic system have the ability to respond to the lesion to repopulate missing cells. The regenerative neuro- or gliogenesis in situ can, at least in part, endogenously compensate injured neural elements, and achieve a self-repair of neurodegenerative disorders such as Parkinson's disease.  (+info)

(2/1106) Differentiation versus plasticity: fixing the fate of undetermined adult stem cells.

Adult mesenchymal stem cells own a considerable plasticity, which enables them to respond to various extra- and intracellular cues and exert, at least partially, various differentiation pathways. Recently, we have shown that multipotent adult stem cells (MASCs) derived from the mouse bone marrow (mBM-MASCs) consist of distinct cell populations that have similar differentiation abilities but differ in the expression of several stem cell markers. Despite their remarkable developmental potential MASCs seem to miss crucial components to complete specific differentiation programs necessary to acquire a fully functional phenotype. A thorough analysis of active and inactive regulatory circuits in multipotent adult stem cells might lead the way to a controlled programming of these cells and rational therapeutic applications.  (+info)

(3/1106) The consensus of the task force of the European Society of Cardiology concerning the clinical investigation of the use of autologous adult stem cells for repair of the heart.

A task force has been established by the European Society of Cardiology to investigate the role of progenitor/stem cell therapy in the treatment of cardiovascular disease. This article is the consensus of this group, of what clinical studies are needed in this field, and the challenges to be addressed in the translation of progenitor/stem cell biology to repair of the heart.  (+info)

(4/1106) X inactivation patterns of closely, but not distantly, related cells are highly correlated: little evidence for stem cell plasticity in normal females.

The early, random nature of X inactivation should cause related cells to have similar, but distinctive, active X chromosomes. We assessed the frequency of stem cell plasticity using X inactivation proportions (XIPs), determined at the human androgen receptor locus, in paired tissue samples from healthy individuals. Tissues sampled were stomach (n = 18 informative females), duodenum (n = 18), colon (n = 10) with corresponding peripheral blood samples (n = 33), and varicose veins (n = 28) with corresponding T cells (n = 26) and peripheral blood granulocytes (n = 25). XIPs from samples thought to have common stem cell origins were highly correlated: multiple samples from single vein, r = .80 (n = 24); T cells versus granulocytes, r = .67 (n = 23); duodenum versus stomach, r = .63 (n = 12). Blood cells and vessels are derived from a common hemangioblast, but XIP correlations were moderate or poor: vein versus T cells, r = .42 (n = 26); vein versus granulocytes, r = .11 (n = 25). X inactivation is believed to be a late process in gut, especially hind-gut, with corresponding independence from blood precursors. Correlations with blood cells were low: stomach, r = .23 (18); duodenum, r = .21 (18); colon, r = .034 (10). Any crossover of stem cells between different organs during adult life should increase correlations with age; no such increase was seen. This study confirms that XIPs can be used to track stem cell populations, provides a theoretical basis for the power of such studies, and indicates that hemopoietic stem cell plasticity is, at most, uncommon in normal humans.  (+info)

(5/1106) A role for angiotensin-converting enzyme in the characterization, enrichment, and proliferation potential of adult murine pituitary colony-forming cells.

Recently, we described a rare cell type within the adult murine pituitary gland with progenitor cell hallmarks (PCFCs). PCFCs are contained exclusively within a subpopulation of cells that import fluorescent beta-Ala-Lys-Nepsilon-AMCA (7-amino-4-methylcoumarin-3-acetic acid). Herein, we investigate the utility of cell surface molecules angiotensin-converting enzyme (ACE) and stem cell antigen-1 (Sca-1) to further enrich for PCFCs. ACE and Sca-1 were expressed on 61% and 55% of AMCA(+)CD45(-)CD31(-) cells, respectively, and coexpressed on 38%. ACE(+)Sca-1(+)AMCA(+) cells enriched for PCFCs by 195-fold over unselected cells. ACE(+)AMCA(+) cells enriched for PCFCs by 170-fold, and colonies were twofold larger than for AMCA(+) selection alone. Conversely, ACE(-)-selected cells reduced both colony-forming activity and size. Notably, colonies generated from AMCA(+) cells obtained from ACE(null) mice were 2.7-fold smaller than for wild-type mice. These data identify ACE as a previously unrecognized marker of PCFCs and suggest that ACE is functionally important for PCFC proliferation. Anatomically, the cells that imported AMCA and expressed ACE were situated in the marginal epithelial cell layer of the pituitary cleft and in the adjacent subluminal zone, thus supporting previous proposals that the luminal zone is a source of precursor cells in the adult pituitary.  (+info)

(6/1106) Regrow or repair: potential regenerative therapies for the kidney.

Regenerative medicine is being heralded in a similar way as gene therapy was some 15 yr ago. It is an area of intense excitement and potential, as well as myth and disinformation. However, with the increasing rate of end-stage renal failure and limited alternatives for its treatment, we must begin to investigate seriously potential regenerative approaches for the kidney. This review defines which regenerative options there might be for renal disease, summarizes the progress that has been made to date, and investigates some of the unique obstacles to such treatments that the kidney presents. The options discussed include in situ organ repair via bone marrow recruitment or dedifferentiation; ex vivo stem cell therapies, including both autologous and nonautologous options; and bioengineering approaches for the creation of a replacement organ.  (+info)

(7/1106) Cell cycle quiescence of early lymphoid progenitors in adult bone marrow.

Lymphocyte production in bone marrow (BM) requires substantial cell division, but the relationship between largely quiescent stem cells and dividing lymphoid progenitors is poorly understood. Therefore, the proliferation and cell cycle status of murine hematopoietic progenitors that have just initiated the lymphoid differentiation program represented the focus of this study. Continuous bromo-2'-deoxyuridine (BrdU) incorporation and DNA/RNA analysis by flow cytometry revealed that a surprisingly large fraction of RAG-1(+)c-kit(hi) early lymphoid progenitors (ELPs) and RAG-1(+)c-kit(lo) pro-lymphocytes (Pro-Ls) in adult BM were in cell cycle quiescence. In contrast, their counterparts in 14-day fetal liver actively proliferated. Indeed, the growth fraction (cells in G(1)-S-G(2)-M phases) of fetal ELPs was on average 80% versus only 30% for adult ELPs. After 5-fluorouracil treatment, as many as 60% of the adult ELP-enriched population was in G(1)-S-G(2)-M and 34% incorporated BrdU in 6 hours. Transcripts for Bcl-2, p21Cip1/Waf1, and p27 Kip1 cell cycle regulatory genes correlated inversely well with proliferative activity. Interestingly, adult lymphoid progenitors in rebound had the high potential for B lymphopoiesis in culture typical of their fetal counterparts. Thus, lymphocyte production is sustained during adult life by quiescent primitive progenitors that divide intermittently. Some, but not all, aspects of the fetal differentiation program are reacquired after chemotherapy.  (+info)

(8/1106) Multipotent adult progenitor cells from swine bone marrow.

We show that multipotent adult progenitor cells (MAPCs) can be derived from both postnatal and fetal swine bone marrow (BM). Although swine MAPC (swMAPC) cultures are initially mixed, cultures are phenotypically homogenous by 50 population doublings (PDs) and can be maintained as such for more than 100 PDs. swMAPCs are negative for CD44, CD45, and major histocompatibility complex (MHC) classes I and II; express octamer binding transcription factor 3a (Oct3a) mRNA and protein at levels close to those seen in human ESCs (hESCs); and have telomerase activity preventing telomere shortening even after 100 PDs. Using quantitative-reverse transcription-polymerase chain reaction (Q-RT-PCR), immunofluorescence, and functional assays, we demonstrate that swMAPCs differentiate into chondrocytes, adipocytes, osteoblasts, smooth muscle cells, endothelium, hepatocyte-like cells, and neuron-like cells. Consistent with what we have shown for human and rodent MAPCs, Q-RT-PCR demonstrated a significant upregulation of transcription factors and other lineage-specific transcripts in a time-dependent fashion similar to development. When swMAPCs were passaged for 3-6 passages at high density (2,000-8,000 cells per cm(2)), Oct3a mRNA levels were no longer detectable, cells acquired the phenotype of mesenchymal stem cells (CD44(+), MHC class I(+)), and could differentiate into typical mesenchymal lineages (adipocytes, osteoblasts, and chondroblasts), but not endothelium, hepatocyte-like cells, or neuron-like cells. Even if cultures were subsequently replated at low density (approximately 100-500 cells per cm(2)) for >20 PDs, Oct3a was not re-expressed, nor were cells capable of differentiating to cells other than mesenchymal-type cells. This suggests that the phenotype and functional characteristics of swMAPCs may not be an in vitro culture phenomenon.  (+info)

*  Embryoid body
"Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors". Cell. 131 (5): 861-872. doi:10.1016/j. ... Scalable Embryonic Stem Cell Differentiation Culture". Stem Cells. 22 (3): 275-282. doi:10.1634/stemcells.22-3-275. PMID ... and BMP Signaling Regulate Distinct Stages in the Developmental Pathway from Embryonic Stem Cells to Blood". Cell Stem Cell. 2 ... "Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors". Cell. 126 (4): 663- ...
*  Adult stem cell
... such as mesenchymal stem cell, adipose-derived stem cell, endothelial stem cell, etc.). A great deal of adult stem cell ... The extracted stem cells are known as human adult germline stem cells (GSCs) Multipotent stem cells have also been derived from ... "Do Pluripotent Stem Cells Exist in Adult Mice as Very Small Embryonic Stem Cells?". Stem Cell Reports. 1 (2): 198-208. doi: ... pluripotent stem cells equivalent to embryonic stem cells have been derived from human adult skin tissue. Other adult stem ...
*  Phoebe S. Leboy
She later focused upon bone-forming adult stem cells. Her research placed her at the forefront of epigenetics and regenerative ... She was promoted to full professor in the dental school and graduate group in cell and molecular biology (1976-2000). Leboy ...
*  2016 in science
16 June - Researchers at Massachusetts General Hospital announce a new method for long-term culturing of adult stem cells. 20 ... pluripotent stem cells can be derived from a human embryo. One of the most flexible types of stem cell, these can develop into ... "New procedure allows long-term culturing of adult stem cells". Science Daily. 16 June 2016. Retrieved 23 June 2016. "China ... Their technique is the first time a new gene has been inserted into a precise DNA location in adult cells that no longer divide ...
*  Cancer stem cell
Origin hypotheses include mutants in developing stem or progenitor cells, mutants in adult stem cells or adult progenitor cells ... "Critical appraisal of the side population assay in stem cell and cancer stem cell research". Cell stem cell. 8 (2): 136-47. doi ... They examined cancer stem cell plasticity in which cancer stem cells can transition between non-cancer stem cells (Non-CSC) and ... a critical review of sphere-formation as an assay for stem cells". Cell stem cell. 8 (5): 486-98. doi:10.1016/j.stem.2011.04. ...
*  Developmental biology
Wagner D.E.; Wang I.E.; Reddien P.W. (2011). "Clonogenic Neoblasts Are Pluripotent Adult Stem Cells That Underlie Planarian ... When cells on one side of a stem grow longer and faster than cells on the other side, the stem will bend to the side of the ... Both of these examples have continuous cell turnover fed by stem cells and, at least in planaria, at least some of the stem ... A single tissue, formed from a single type of progenitor cell or stem cell, often consists of several differentiated cell types ...
*  Neocardiogenesis
"Using Adult Stem Cells to Treat Heart Failure- Fact or Fiction?" Heart, Lung and Circulation 17S:S48-S54. Wollert, K.C. 2008. " ... Features of progenitor cells and stem cells The heart has the potential to repair itself when damaged using progenitor and stem ... a special type of stem cell with long telomeres located in the storage areas of the heart) and circulating stem cells induce ... Cardiomyocytes (muscle cells of the heart) were thought to be terminally differentiated cells that were irreplaceable and thus ...
*  Stem-cell niche
The CSC niche is very similar to normal stem cells niche (Embryonic Stem Cell (ESC), Adult Stem Cell ASC) in function ( ... cell-cell interactions between stem cells, as well as interactions between stem cells and neighbouring differentiated cells, ... It is believed that correct culturing conditions of adult stem cells needs to be improved so that adult stem cells can maintain ... The GSC niche consists of necessary somatic cells-terminal filament cells, cap cells, escort cells, and other stem cells which ...
*  GPR125
2007). "Generation of functional multipotent adult stem cells from GPR125+ germline progenitors". Nature. 449 (7160): 346-50. ... 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635-48. doi:10.1016/ ...
*  Marc Wilkins (geneticist)
This company has established treatments for osteoarthritis using autologous adult stem cells. Dr Wilkins is currently a ...
*  Progerin
Cell Biol. 10 (4): 452-9. doi:10.1038/ncb1708. PMC 2396576 . PMID 18311132. "Adult stem cell changes underlie rare genetic ... Scaffidi P, Misteli T (April 2008). "Lamin A-dependent misregulation of adult stem cells associated with accelerated ageing". ... Progerin activates genes that regulate stem cell differentiation via the Notch signaling pathway. In Hutchinson-Gilford ... Recently, rapamycin has been shown to prevent progerin aggregates in cells and hence delay premature aging. Progerin, which has ...
*  Embryonic stem cell
Pluripotency distinguishes embryonic stem cells from adult stem cells found in adults; while embryonic stem cells can generate ... Embryonic stem cells (ES cells) are pluripotent stem cells derived from the inner cell mass of a blastocyst, an early-stage pre ... Embryoid body Embryonic Stem Cell Research Oversight Committees Fetal tissue implant Stem cell controversy Induced stem cells ... Stem cell banks or more recently by reprogramming of somatic cells with defined factors (e.g. induced pluripotent stem cells). ...
*  Douglas Scherr
2007). "Generation of functional multipotent adult stem cells from GPR125+ germline progenitors". Nature. 449 (7160): 346-50. ... "Decreased expression of the human stem cell marker, Rex-1 (zfp-42), in renal cell carcinoma". Carcinogenesis. 27 (3): 499-507. ... Barocas, DA; Mathew, S; Delpizzo, JJ; Vaughan Ed, ED; Sosa, RE; Fine, RG; Akhtar, M; Scherr, DS (2007). "Renal cell carcinoma ... Barocas, DA; Rabbani, F; Scherr, DS; Vaughan Ed, ED (2006). "A population-based study of renal cell carcinoma and prostate ...
*  Cellular cardiomyoplasty
It has been shown in several studies that adult stem cells do have cardiogenic potential. Presently, the success of adult stem ... A third cell line that shows great promise and has no known safety concerns is the adult stem cell derived from bone marrow or ... September 2003). "Adult cardiac stem cells are multipotent and support myocardial regeneration". Cell. 114 (6): 763-776. doi: ... Human-induced pluripotent stem cells (iPSCs) are a cell line derived from somatic cells which have been induced through a ...
*  Lori Ann Setton
"Chondrocytic differentiation of human adipose-derived adult stem cells in elastin-like polypeptide". Biomaterials. 27 (1): 91- ... "Osmolarity regulates gene expression in intervertebral disc cells determined by gene array and real-time quantitative RT-PCR". ... zonal-specific changes in gene expression for extracellular matrix and cytoskeletal proteins in intervertebral disc cells in ...
*  Inhibitor of DNA-binding protein
An increase in ID expression is seen in embryonic and adult stem cells. ID proteins also promote cell cycle progression, ... Lasorella A, Benezra R, Iavarone A (February 2014). "The ID proteins: master regulators of cancer stem cells and tumour ... ID proteins are key regulators of development where they function to prevent premature differentiation of stem cells. By ... therapies without inhibiting the functioning of most normal cells because they are highly expressed in embryonic stem cells, ...
*  Evolutionary dynamics
... since an understanding of tissue cell kinetics, architecture, and development from adult stem cells has important implications ... "Evolutionary dynamics of adult stem cells: comparison of random and immortal-strand segregation mechanisms". Physical Review E ...
*  Larry Lemanski
He has studied cardiac mutant axolotls, transgenic mice, and induced pluripotent adult stem cells. His goals have been to ... that have the capacity to promote cardiac myofibrillogenesis in non-muscle cells. He is pursuing the mechanism of this exciting ... interests concern a study of myofibrillogenesis and heart inductive processes in developing embryonic hearts at the cell and ...
*  Pluristem Therapeutics
Pluristem has made the strategic decision to work only with adult stem cells, purified from the placenta after birth and, ... According to the company's website, it extracts adult stem cells exclusively from postnatal placentas. Pluristem was founded in ... Nevada corporation Cell therapy Mesenchymal stem cell Acute limb ischemia Buerger's disease List of Israeli companies quoted on ... "Pluristem stem cell therapy saves a patient, shares jump". The Baltimore Sun. Reuters. Retrieved 9 May 2012. "Pluristem stem ...
*  Aneuploidy
"Aneuploidy directly contribute to carcinogenesis by disrupting the asymmetric division of adult stem cells". Medical Hypotheses ... A cell with the correct number of chromosomes is called a euploid cell. An extra or missing chromosome is a common cause of ... One daughter cell would have a normal complement of chromosomes; the second would lack one. A third daughter cell may end up ... suggested that aneuploidy might directly contribute to carcinogenesis by disrupting the asymmetric division of adult stem cells ...
*  Regeneration (biology)
... the use of adult somatic stem cells and the dedifferentiation and/or transdifferentiation of cells, and more than one mode can ... "Robust G2 Pausing of Adult Stem Cells in Hydra". Differentiation. Elsevier. 87: 83-99. doi:10.1016/j.diff.2014.03.001. T.H. ... Wagner, D. E.; Wang, I. E.; Reddien, P. W. "Clonogenic Neoblasts Are Pluripotent Adult Stem Cells That Underlie Planarian ... First, adult cells de-differentiate into progenitor cells which will replace the tissues they are derived from. Second, these ...
*  Stem cell controversy
Not all stem cell research involves the human embryos. For example, adult stem cells, amniotic stem cells, and induced ... embryonic stem cells are likely to be easier to isolate and grow ex vivo than adult stem cells. Embryonic stem cells divide ... some evidence suggests that adult stem cell plasticity may exist, increasing the number of cell types a given adult stem cell ... there have been many advances in adult stem cell research, including a recent study where pluripotent adult stem cells were ...
*  Amniotic stem cells
Their enhanced stability and plasticity compared to adult stem cells may also be an advantage. Stem cells from both the ... This characteristic differentiates them from embryonic stem cells but indicates similarities with adult stem cells. However, ... Evidence in favour of their embryonic stem cell nature is the cells' ability to produce clones. The use of amniotic stem cells ... Amniotic stem cells are the mixture of stem cells that can be obtained from the amniotic fluid as well as the amniotic membrane ...
*  María Blasco Marhuenda
Identification of the longest telomeres as a universal feature of adult stem cell niches; The finding that telomerase ... a general signature of adult stem cell compartments". Genes & Development. 22: 654-667. doi:10.1101/gad.451008. PMC 2259034 . ... Demonstration that telomerase activity and telomere length determine the regenerative capacity of adult stem cells; ... Cell. 135 (4): 609-622. doi:10.1016/j.cell.2008.09.034. PMID 19013273. arion, R.M.; Strati, K.; Li, H.; Murga, M.; Blanco, R.; ...
*  Azacitidine
In research, 5-azacitidine is commonly used for promoting cardiomyocyte differentiation of adult stem cells. However, it has ... Azacitidine causes anemia (low red blood cell counts), neutropenia (low white blood cell counts), and thrombocytopenia (low ... doi:10.1089/cell.2014.0021. PMID 25090621. Martens, U.M., ed. (2010). "11 5-Azacytidine/Azacitidine". Small molecules in ... resulting in cell death. Azacitidine is a ribonucleoside, so it is incorporated into RNA to a larger extent than into DNA. In ...
*  Scarring hair loss
If the stem cells and sebaceous gland are destroyed, there is then no possibility for regeneration of the hair follicle, and ... Cicatricial alopecias affect both men and women, most commonly adults, although all ages may be affected. Epidemiologic studies ... However, all cicatricial alopecias involve inflammation directed at the upper part of the hair follicle where the stem cells ... The goal of treatment is to decrease or eliminate the lymphocytic inflammatory cells that are attacking and destroying the hair ...
*  Facial Autologous Muscular Injection
FAMI consists of an autograft of adult stem cells in order to rebuild muscles and bones. The adult stem cells are taken from an ... The collected fat and stem cells are concentrated and refined. The stem cells are then re-injected into the muscles of the face ... FAMI is an Adult stem cell procedure used to address the loss of volume in the face due to aging or surgery repair in restoring ... The procedure involves removing adult stem cells of fatty tissue from lower body, and refining it to be able to re-inject ...
Multipotent adult progenitor cells are a recently described population of stem - Progress in the Preclinical Discovery and...  Multipotent adult progenitor cells are a recently described population of stem - Progress in the Preclinical Discovery and...
Multipotent adult progenitor cells are a recently described population of stem cells derived from the bone marrow stroma. ... Multipotent adult progenitor cells are a recently described population of stem. February 13, 2018. ground ... multipotent adult progenitor cells along mesodermal lineages and exhibited the enhanced expression of alkaline phosphatase and ... Our results indicate that multipotent adult progenitor cells have the potential to better promote tissue regeneration and ...
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Adipose-Derived Mesenchymal Stem Cells; Normal, Human ATCC ® PCS-5  Adipose-Derived Mesenchymal Stem Cells; Normal, Human ATCC ® PCS-5
... when grown in Mesenchymal Stem Cell Basal Media supplemented with Mesenchymal Stem Cell Growth Kit Low serum components, ... provide an ideal cell system to propagate mesenchymal stem cells in low serum (2% FBS) conditions. When maintained under ... The cells are cryopreserved at the second passage to ensure the highest viability and plating efficiency. ATCC ® Primary Cell ... ATCC Normal Human Adipose-Derived Mesenchymal Stem Cells have been shown to be multipotent, capable of differentiating down the ...
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In vitro and in vivo arterial differentiation of human multipotent adult progenitor cells  In vitro and in vivo arterial differentiation of human multipotent adult progenitor cells
These results represent the first demonstration of adult stem cells with the potential to be differentiated into different ... Many stem cell types have been shown to differentiate into endothelial cells (ECs); however, their specification to arterial or ... 2) Stem Cell Institute, University of Minnesota Medical School, Minneapolis. (3) Center for Molecular and Vascular Biology, ... We tested whether a specific arterial or venous EC fate could be induced in human multipotent adult progenitor cells (hMAPCs) ...
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UConn Advance - November 28, 2006 - State gives $12 million to UConn for stem cell research  UConn Advance - November 28, 2006 - State gives $12 million to UConn for stem cell research
20 million awarded by the Connecticut Stem Cell Research Advisory Committee to advance embryonic and human adult stem cell ... The grants also will expand UConn's cross-campus Stem Cell Institute, which is committed to stem cell biology, while allowing ... Stem cells are the 'building blocks' for every type of cell in the body, capable of maturing into any tissue type including ... Research on stem cells promises to advance human health care by developing innovative cell transplantation therapies for ...
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INH1 IC50  INH1 IC50
Multipotent adult progenitor cells are a recently described population of stem cells derived from the bone marrow stroma. ... Multipotent adult progenitor cells are a recently described population of stem. February 13, 2018. ground ... multipotent adult progenitor cells along mesodermal lineages and exhibited the enhanced expression of alkaline phosphatase and ... In combination with a demineralized bone matrix scaffold, multipotent adult progenitor cells exhibited enhanced ...
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Papers against stem cell research  Papers against stem cell research
... embryonic stem cell research has not produced a single medical treatment, where ethical, adult stem cell research has produced ... embryonic stem cell research has not produced a single medical treatment, where ethical, adult stem cell research has produced ... Papers against stem cell research. 22.02.2010EssayComments: 0. E Stem Cell Debates: Lessons for Science and Politics. Pendices ... Cells Weekly is a digest of the most interesting news and events in stem cell research, cell therapy and regenerative medicine ...
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Adult stem cells - Conservapedia  Adult stem cells - Conservapedia
Adult stem cells are multipotent, semi-differentiated, cells that exist in all tissues. "Adult stem cell", however, is not the ... Functionally, adult stem cells are very different from embryonic stem cells. Whereas embryonic stem cells are omnipotent, and ... The two most well-studied examples of adult stem cells are the hematopoietic stem cells, which give rise to blood cells, and ... As multipotent cells, most adult stem cell types can generate cells of several different types. However, because they are ...
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Adult stem cells produce treatment breakthroughs - Washington Times  Adult stem cells produce treatment breakthroughs - Washington Times
... but medical breakthroughs have been made using adult stem cells and other body cells. ... Debate continues over human embryonic stem cell research, ... Adult bone marrow stem cells also were shown to help heal three ... Debate continues over human embryonic stem cell research, but medical breakthroughs have been made using adult stem cells and ... that adult stem cells and other types of body cells hold more promise for medical treatments then do human embryonic stem cells ...
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adult stem cells |  adult stem cells |
Adult or Repair Stem Cells: The Future of Healing November 16, 2014 Health Problems 0 ...
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Corneas Grown Via Adult Stem Cells  Corneas Grown Via Adult Stem Cells
Researchers at Massachusetts Eye and Ear Research Institute revealed that they have been able to regrow corneas from adult stem ... Stem Cells - Cord Blood Stem Cells - Fundamentals Parkinsons Disease Surgical Treatment Genetics and Stem Cells Bone Marrow ... Stem Cells - Fundamentals. Encyclopedia section of medindia gives general info about Stem Cells ... Preferred Term is Hematopoietic stem cell transplantation. In this stem cell from bone marrow are injected into a recipient ...
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New Hurdle for Adult Stem Cells  New Hurdle for Adult Stem Cells
The safety of reprogramming adult cells, an experimental technique which supporters say could one day lead to the growing of ... Stem Cells - Cord Blood Stem Cells - Fundamentals Parkinsons Disease Surgical Treatment Genetics and Stem Cells Stem Cells ... Stem Cells - Fundamentals. Encyclopedia section of medindia gives general info about Stem Cells ... found that the transformation from adult cell to stem cell was incomplete. DNA errors pop up in an area of the genome called ...
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Researchers Find Adult Stem Cells in Skin - Scientific American  Researchers Find Adult Stem Cells in Skin - Scientific American
... noncontroversial source of stem cells. Researchers at McGill University isolated adult stem cells able to differentiate into a ... The newly discovered cells are distinct from other adult-derived stem cells, such as those originating from bone marrow, and ... muscle cells and fat cells. "We believe our discovery is important as we have identified an exciting new stem cell from a ... In the wake of the federal governments recent decision to limit embryonic stem cell research to existing cell lines, Canadian ...
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Protocols for adult stem cells (eBook, 2010) []  Protocols for adult stem cells (eBook, 2010) []
Protocols for adult stem cells. [Irina M Conboy;] -- The study of adult stem cells has surged in recent years. Because they are ... stem_cells> # Adult Stem Cells a schema:Intangible ;. schema:name "Adult Stem Cells"@en ;. . ... Stem Cells schema:about adult_stem_cells> ; # Adult Stem Cells ... cells> # Stem Cells a schema:Intangible ;. schema:name "Stem Cells"@en ;. . ...
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Adult stem cells offer ethical, effective cures, speakers say  Adult stem cells offer ethical, effective cures, speakers say
... that was the message of a three-day conference at the Vatican on adult stem-cell thera... ... the church supports research and therapies utilizing adult stem cells, which can develop into a variety of specialized cells, ... Adult stem cells offer ethical, effective cures, speakers say. by Carol Glatz by Catholic News Service ... But he said, "I wouldn't have made that call had I known what I learned" about adult stem-cell science. Now that that science ...
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Study finds adult stem cells can replicate -  Study finds adult stem cells can replicate -
... stem cells have the same ability as embryonic stem cells to multiply, a previously unknown characteristic indicating that post- ... natal stem cells may play an important therapeutic role. ... at Children's Hospital of Pittsburgh have discovered that adult ... Adult and post-natal stem cells are often overlooked in favor of embryonic stem cells in the national debate over the ... "Scientists have typically believed that adult or post-natal stem cells grow old and die much sooner than embryonic stem cells, ...
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Adult Stem Cells: Its Not Pie-in-the-Sky  Adult Stem Cells: It's Not Pie-in-the-Sky
June 12, 2003: Hearing on Advances in Adult and Non-Embryonic Stem Cell Research July 14, 2004: Adult Stem Cell Research ... Reports of 'Master Stem Cell' discoveries 'A stem cell has been found in adults that can turn into every single tissue in the ... In a sense they have the potential to act like tumor cells. This is how adult stem cells, and even some umbilical cells, are ... I agree with you...all this damn money and time going into embryonic stem cell research could be going into adult stem cell ...
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adult stem cells Protocols and Video...  'adult stem cells' Protocols and Video...
Xenotransplantation of Human Stem Cells into the Chicken Embryo', 'Isolation and Culture of Adult Epithelial Stem Cells from ... Isolation of Early Hematopoietic Stem Cells from Murine Yolk Sac and AGM', 'Embryonic Stem Cell-Derived Endothelial Cells for ... Differentiation of Newborn Mouse Skin Derived Stem Cells into Germ-like Cells In vitro', 'Programming Stem Cells for ... Dissection of the Adult Zebrafish Kidney', 'Isolation and Culture of Neural Crest Stem Cells from Human Hair Follicles', 'Stem ...
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Multiple Adult Stem Cells May Make Treatment Trickier  Multiple Adult Stem Cells May Make Treatment Trickier
... a University of Utah researcher finds-which means therapies based on the cells could be more complicated... Health News ... There is probably more than one type of adult stem cell in the intestines and other organs, ... Multiple Adult Stem Cells May Make Treatment Trickier Researchers find different types in organs, complicating search for ... Newser) - There is probably more than one type of adult stem cell in the intestines and other organs, a University of Utah ...
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New Lease on Life for Adult Stem Cells | ALZFORUM  New Lease on Life for Adult Stem Cells | ALZFORUM
Adult stem cells in the intestine and skin of mice can be induced to multiply massively by the introduction of a master gene ... The remarkable expansion of adult stem cells was induced by forced expression of the protein Oct-4, a transcription factor that ... There is much optimism that neural stem cells may help to treat cell losses associated with a variety of neurodegenerative ... to stem cells and their differentiation in mammals. Their data strongly suggest that ectopic expression of Oct-4 in adult mice ...
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holistic wellness in Adult Stem Cells Repair Body |  'holistic wellness' in Adult Stem Cells Repair Body |
Everybody in the world has Adult Stem Cells, and every body uses adult stem cells every day.  Fact: Adult Stem Cells are ... If you want more circulating Adult Stem Cells in your blood .. investigate stem cell nutrition and stem cell enhancer ... nbsp;I am a Stem Cells for Wellness Researcher and I am here to answer your stem cell options questions. filtered by holistic ... Adult Stem Cells Repair Body "Stem Cells for All" ... Everybody in the world has Adult Stem Cells, and every body uses adult ...
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Shuttle Atlantis Carries Adult Stem Cells Into Space - Pioneering Experiments for NASA  Shuttle Atlantis Carries Adult Stem Cells Into Space - Pioneering Experiments for NASA
... the shuttle Atlantis carried the stem cells of six adults to the ... Shuttle Atlantis Carries Adult Stem Cells Into Space - ... Sant Antonio expects that some of the stem cells may remain on the International Space Station, while some of the stem cells ... Not until the final shuttle mission did the adult stem cells end up in space. "NASA came through in a huge way," said Dr. Sant ... On its 135th and final flight in NASA's shuttle program, the shuttle Atlantis carried the stem cells of six adults to the ...
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Adult Stem Cells Can Repair Damaged Heart - MedNews  Adult Stem Cells Can Repair Damaged Heart - MedNews
The phase 1 study of 53 patients found that stem cells from donor bone marrow pro ... Adult stem cells appear to help repair heart attack damage, a new study shows. ... Adult Stem Cells Can Repair Damaged Heart. Print this page FRIDAY, Dec. 4 -- Adult stem cells appear to help repair heart ... This is the strongest evidence so far that adult stem cells can repair heart attack damage, the Rush University Medical Center ...
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Adult stem cells: the better option  Adult stem cells: the better option
... kidney cells, nerve cells, blood cells, skin cells, etc. They have been called master cells.. Embryonic stem cells = found ... Inner cell mass = the stem cells found inside a blastocyst.. Outer cell mass = the protective layer of cells surrounding a ... For example umbilical-cord blood and placenta blood are both rich in stem cells. Scientists have found stem cells in adults in ... The stem cells may have the capacity to do this.. More specifically, stem cells are the cells from which different kinds of ...
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Medical Xpress - adult stem cells  Medical Xpress - adult stem cells
Adult stem cell. Adult stem cells are undifferentiated cells, found throughout the body after embryonic development, that ... Related topics: stem cells · embryonic stem cells · cells · stem cell research · bone marrow Sorry, no news articles match your ... potentially regenerating the entire organ from a few cells. Unlike embryonic stem cells, the use of adult stem cells in ... Also known as somatic stem cells (from Greek Σωματικóς, meaning of the body), they can be found in juvenile as well as adult ...
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Early Successes   Adult Stem Cells (Mesenchymal Stem Cells)  Early Successes Adult Stem Cells (Mesenchymal Stem Cells)
These cells have shown the potential to form many different kinds of cell types and tissues, including functional hepatocyte- ... Adult stem cells have shown great promise in many published studies. ... Early Successes Adult Stem Cells. *Human mesenchymal stem cells turned on Functional and physical units of heredity passed from ... Adult stem cells have shown great promise in many published studies. These cells have shown the potential to form many ...
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  • Until now, it has been generally believed that embryonic stem cells had a greater capacity to multiply than post-natal stem cells, making them more desirable to research as a potential treatment, according to Johnny Huard, PhD, director of the Growth and Development Laboratory at Children's Hospital of Pittsburgh. (
  • With post-natal stem cells taken from the recipient and then reintroduced in an autologous manner, rejection would not be an issue. (
  • Strauer BE, Brehm M, Zeus T, Kostering M, Hernandez A, Sorg RV, Kogler G and Wernet P. Repair of infarcted myocardium by autologous intracoronary mononuclear bone marrow cell transplantation in humans. (
  • This company has established treatments for osteoarthritis using autologous adult stem cells. (
  • In a study that is currently underway (February 2012), however, more positive results were being reported: In the SCIPIO trial, patients treated with autologous cardiac stem cells post MI have been reported to be showing statistically significant increases in LVEF and reduction in infarct size over the control group at four months after implant. (
  • The embryo s stem cells are then harvested a process that always destroys the embryo. (
  • Instead of implanting the embryo into a woman's uterus, it is used to harvest stem cells. (
  • Pope Benedict XVI has reaffirmed his opposition to embryonic stem cell research, saying it's morally wrong to destroy an embryo no matter how beneficial the resulting treatment is. (
  • While NIH continues to waste more taxpayer funds on destructive embryo research, adult stem cells are the only stem cell treating patients, with more and more published evidence accumulating every week. (
  • For example, in the neural plate of the embryo this system operates to generate a population of neuronal precursor cells in which NeuroD is highly expressed. (
  • Embryonic stem cells (ES cells) are pluripotent stem cells derived from the inner cell mass of a blastocyst, an early-stage pre-implantation embryo. (
  • Only cells from an embryo at the morula stage or earlier are truly totipotent, meaning that they are able to form all cell types including placental cells. (
  • Is it just to destroy an embryo cell if it has the potential to cure countless numbers of patients? (
  • Political leaders are debating how to regulate and fund research studies that involve the techniques used to remove the embryo cells. (
  • Originally it was proposed that the MSCs were discarded from the embryo at the end of their life cycle but since the cells remained viable in the amniotic fluid and were able to proliferate in culture this hypothesis was overturned. (
  • As scientists in the field devise better ways to generate these cells (new techniques are a current area of much research--there have been at least 40 published since 2009), they may become more clinically useful. (
  • Toronto scientists are taking stem cells from the eye, using them to generate new cells in a lab and transplanting the new cells into damaged eyes, hoping to improve function, Canada's Edmonton Journal reported Nov. 30. (
  • In the wake of the federal governments recent decision to limit embryonic stem cell research to existing cell lines, Canadian scientists announced they have discovered a new, noncontroversial source of stem cells. (
  • The newly discovered cells are distinct from other adult-derived stem cells, such as those originating from bone marrow, and retain their ability to morph into diverse cell types for up to a year, the scientists report. (
  • Scientists have typically believed that adult or post-natal stem cells grow old and die much sooner than embryonic stem cells, but this study demonstrates that is not the case," said Dr. Huard, senior author of the study. (
  • My belief is that this study should erase doubts scientists may have had about the potential effectiveness of post-natal stem cells. (
  • Scientists had hoped a single stem cell could fix damage to an entire organ, but the findings suggest the power of one cell could be limited, the BBC notes. (
  • Because many diseases result from the death or dysfunction of a single cell type, scientists believe that the introduction of healthy cells of this type into a patient may restore lost or compromised function. (
  • Now that human embryonic stem cells can be isolated and multiplied in the laboratory, some scientists believe that treatments for a variety of diseases may be within reach. (
  • They have the potential to become any type of cell, if scientists can prod and program them in the right direction. (
  • 7 January Scientists report that, about 800 million years ago, a minor genetic change in a single molecule, called GK-PID, may have allowed organisms to go from a single cell organism to one of many cells. (
  • Cell therapy originated in the nineteenth century when scientists experimented by injecting animal material in an attempt to prevent and treat illness. (
  • In addition to searching for a cure for DMD, Dr. Huard's laboratory also is researching the use of stem cells to repair injured muscle following sports-related injuries, as well as to treat cardiac, joint and bone injuries. (
  • Neocardiogenesis replaces dead cardiac muscle cells with living cells so that both the structure and function of the heart are maintained. (
  • Cardiomyocytes (muscle cells of the heart) were thought to be terminally differentiated cells that were irreplaceable and thus required to maintain cardiac function throughout life. (
  • The activation of cardiac progenitor cells (a special type of stem cell with long telomeres located in the storage areas of the heart) and circulating stem cells induce cardiomyocytes to proliferate. (
  • Quaini F, Cigola E, Lagrasta C, Saccani G, Quaini E, Rossi C, Olivetti G and Anversa P. End-stage cardiac failure in humans is coupled with the induction of proliferating cell nuclear antigen and nuclear mitotic division in ventricular myocytes. (
  • He has studied cardiac mutant axolotls, transgenic mice, and induced pluripotent adult stem cells. (
  • He is known for discovering unique and specific ribonucleic acids (RNAs) that have the capacity to promote cardiac myofibrillogenesis in non-muscle cells. (
  • However, it has been suggested that this drug has a compromised efficacy as a cardiac differentiation factor because it promotes the transdifferentiation of cardiac cells to skeletal myocytes. (
  • Cardiac and vascular - Cells are administered locally with the aim of improving heart anatomy and function. (
  • When they switched the gene on in grown mice, within a few days the animal's intestines were full of immature epithelial cells due to the expansion of progenitor cells and a block in their differentiation. (
  • It was reassuring to see that the abnormal accumulation of progenitors was completely reversible, because when the Oct-4 gene was switched off, the immature cells differentiated, and the mice returned to normal. (
  • However, because they are already epigenetically programmed to favor a particular fate, they generally cannot generate cell types outside of their lineage without genetic manipulation. (
  • Whereas embryonic stem cells are omnipotent, and may be coaxed with growth factors into producing any known cell type, adult stem cells are already partially committed to a particular fate and, without genetic manipulation, will only generate a limited number of cell types. (
  • The team tested human skin to determine if it could generate SKPs and concluded that "similar precursors may be present within adult human skin. (
  • Scientific interest in adult stem cells has centered on their ability to divide or self-renew indefinitely, and generate all the cell types of the organ from which they originate, potentially regenerating the entire organ from a few cells. (
  • Andreadis previously showed that the capacity of adult stem cells to form muscle and generate force declines with aging. (
  • The theory suggests that conventional chemotherapies kill differentiated or differentiating cells, which form the bulk of the tumor but do not generate new cells. (
  • while embryonic stem cells can generate all cell types in the body, adult stem cells are multipotent and can produce only a limited number of cell types. (
  • This would generate a daughter cell lacking a copy and a daughter cell with an extra copy. (
  • Debate continues over human embryonic stem cell research, but medical breakthroughs have been made using adult stem cells and other body cells. (
  • These cells also have shown promise in treating human heart patients. (
  • Some say these advancements show that adult stem cells and other types of body cells hold more promise for medical treatments then do human embryonic stem cells. (
  • Embryonic stem cell research has shown positive results in animals but hasn't produced successful human studies. (
  • Even aside from the serious moral issues, embryonic stem cells are very far away from helping any human patient," said Richard Doerflinger, deputy director of the Secretariat for Pro-Life Activities at the U.S. Conference of Catholic Bishops. (
  • The assumption that cells derived from iPSCs are totally immune-tolerant has to be re-evaluated before considering human trials," warned lead investigator Yang Xu, a professor of biology at the University of California at San Diego. (
  • Among the dozens of speakers invited to help translate the new developments into layman's terms were Nobel Prize winner John B. Gurdon -- a pioneer of adult stem-cell research -- and Tommy G. Thompson -- former U.S. secretary of Health and Human Services and former governor of Wisconsin. (
  • Speculation regarding the scientific promise of human embryonic stem cells leads some to dismiss the ethical questions raised by the embryo's destruction. (
  • However, embryonic stem cells (human or animal) have not cured or treated a single human patient. (
  • Fortunately, there are alternative sources of stem cells for research that do not require the destruction of human life. (
  • NASA is hopeful the Human adult stem cell experiments will lead to the reversal of the rapid aging process that zero gravity has on astronauts. (
  • They can transform into about 250 types of specialised cells that make up a human being. (
  • Totipotent cells have the capacity to develop into a complete human being. (
  • NIH Director Francis Collins has approved another human embryonic stem cell line for federal taxpayer funding. (
  • At the end of September, Collins approved three more human embryonic stem cell lines for taxpayer funding . (
  • Prior to that the Obama administration last approved more federal funding for embryonic stem cell research on August 19, when Collins approved four more human embryonic stem cell (hESC) lines for the embryonic stem cell registry. (
  • Human embryonic stem cells are often grown in fibroblastic growth factor-2 containing, fetal bovine serum supplemented media. (
  • Human ES cells measure approximately 14 μm while mouse ES cells are closer to 8 μm. (
  • The ability of transplanted progenitor cells to improve function within the failing heart has been shown in experimental animal models and in some human clinical trials. (
  • Presently, the success of adult stem cells in regenerating human myocardium is just a fraction of what it could be. (
  • Pluristem Therapeutics is an Israeli company engaged in the development of human placental adherent stromal cells for commercial use in disease treatment. (
  • Aneuploidy is the presence of an abnormal number of chromosomes in a cell, for example a human cell having 45 or 47 chromosomes instead of the usual 46. (
  • Most cells in the human body have 23 pairs of chromosomes, or a total of 46 chromosomes. (
  • In early 2009, the FDA approved the first human clinical trials using embryonic stem cells. (
  • Many of the debates surrounding human embryonic stem cells concern issues such as what restrictions should be made on studies using these types of cells. (
  • Much of the criticism has been a result of religious beliefs, and in the most high-profile case, US President George W Bush signed an executive order banning the use of federal funding for any cell lines other than those already in existence, stating at the time, "My position on these issues is shaped by deeply held beliefs," and "I also believe human life is a sacred gift from our creator. (
  • Human leukocyte antigen testing has been utilised to confirm that the MSCs stem from the fetus and not from the mother. (
  • Goodell has been on the faculty of Baylor College of Medicine since 1997 as a member of the Center for Cell and Gene Therapy, and the Departments of Pediatrics, Molecular and Human Genetic, and Immunology. (
  • Although the funds could be used to finance all kinds of stem cell research, it gives priority to human embryonic stem cell research. (
  • In recent times, cell therapy using human material has been recognized as an important field in the treatment of human disease. (
  • Research into human embryonic stem cells is controversial, and regulation varies from country to country, with some countries banning it outright. (
  • In a previous clinical review published in the Journal of the American Medical Association in 2008 , the evidence indicated that adult stem cells were showing success for many diseases , including multiple sclerosis. (
  • The positive effects observed in clinical trials today are a result of the work of donated stem cells that persist in the damaged myocardium for just days to weeks after delivery. (
  • Cell therapy is targeted at many clinical indications in multiple organs and by several modes of cell delivery. (
  • Published scientific evidence over the last few months shows effectiveness of adult stem cells in helping patients with angina pain , aggressive multiple sclerosis , enlarged hearts , systemic sclerosis , and creating new windpipes , to name just a few examples of adult stem cell successes. (
  • In addition, evidence indicated that embryonic stem cells are part of the fluid, although in very small quantities. (
  • Because these CD34+ cells already exist in normal bone marrow, they offer a vast source for potential cell replacement therapy, particularly because they come from a person's own body, eliminating the need to suppress the immune system, which is sometimes required when using adults stem cells derived from other sources," explains Paul Fishman, MD, PhD, professor of neurology at the University of Maryland School of Medicine. (
  • Houston Wellness Clinic offers Stem Cell Therapy, helping many patients restore their aging, sick body back to living a healthy, enjoyable life. (
  • Cell Therapy for Acute Myocardial Infarction. (
  • She is also a member of the Center for Cell and Gene Therapy. (
  • Today two distinct categories of cell therapy are recognized. (
  • The first category is cell therapy in mainstream medicine. (
  • Cell therapy can be defined as therapy in which cellular material is injected into a patient. (
  • The origins of cell therapy can perhaps be traced to the nineteenth century, when Charles-Édouard Brown-Séquard (1817-1894) injected animal testicle extracts in an attempt to stop the effects of aging. (
  • The experimental field of Stem cell therapy has shown promise for new types of treatment. (
  • In mainstream medicine, cell therapy is supported by a distinct healthcare industry which sees strong prospects for future growth. (
  • The proliferative potential of the two groups was unequal and correlated with the cells' location (central or border). (
  • Embryonic stem cell's properties include having a normal karyotype, maintaining high telomerase activity, and exhibiting remarkable long-term proliferative potential. (
  • He currently is working with the stem cells he discovered while searching for a cure for Duchene muscular dystrophy (DMD), a genetic disease that is estimated to affect one in every 3,500 boys. (
  • The investigators also found that the CD34+ cells had a limited lifespan and did not produce teratomas, tumors that sometimes form with the use of embryonic stem cells and adult stem cells cultivated from other methods that require some genetic manipulation. (
  • Such a scenario could result in each daughter cell possessing a disjoint set of genetic material. (
  • Pattern formation in the morphogenesis of an animal is regulated by genetic induction factors that put cells to work after damage has occurred. (
  • The presence of embryonic and foetal cells from all germ layers in the amniotic fluid was gradually determined since the 1980s. (
  • Pluristem is in the process of clinically testing the use of its PLX (PLacental eXpanded) cells in Phase I, Phase II and Phase III trials. (
  • In May 2012, Pluristem reported that its experimental PLacental eXpanded cells were injected into the muscles of a 7-year-old Romanian girl undergoing treatment for bone marrow aplasia disease at the Hadassah Medical Center in Jerusalem. (
  • In September 2012 Pluristem reported saving the life of a third bone marrow disease patient using its PLacental eXpanded cell treatment, again at Jerusalem's Hadassah Medical Center and again under the terms of compassionate use. (
  • Previous research has found that embryonic stem cells could undergo more than 200 population doublings before the cells began to die. (
  • Dr. Deasy, a research assistant professor in the Department of Orthopaedic Surgery at the University of Pittsburgh School of Medicine, discovered that a unique population of muscle-derived stem cells was able to undergo more than 200 population doublings, as well. (
  • In order for a cell to become cancerous it must undergo a significant number of alterations to its DNA sequence. (