Role of nitric oxide-cGMP pathway in adrenomedullin-induced vasodilation in the rat. (1/693)

We previously reported that adrenomedullin (AM), a potent vasodilator peptide discovered in pheochromocytoma cells, stimulates nitric oxide (NO) release in the rat kidney. To further investigate whether the NO-cGMP pathway is involved in the mechanisms of AM-induced vasodilation, we examined the effects of E-4021, a cGMP-specific phosphodiesterase inhibitor, on AM-induced vasorelaxation in aortic rings and perfused kidneys isolated from Wistar rats. We also measured NO release from the kidneys using a chemiluminescence assay. AM (10(-10) to 10(-7) mol/L) relaxed the aorta precontracted with phenylephrine in a dose-dependent manner. Denudation of endothelium (E) attenuated the vasodilatory action of AM (10(-7) mol/L AM: intact (E+) -25.7+/-5.2% versus denuded (E-) -7. 8+/-0.6%, P<0.05). On the other hand, pretreatment with 10(-8) mol/L E-4021 augmented AM-induced vasorelaxation in the intact aorta (-49. 0+/-7.9%, P<0.05) but not in the denuded one. E-4021 also enhanced acetylcholine (ACh)-induced vasorelaxation in the rat intact aorta (10(-7) mol/L ACh -36.6+/-8.4% versus 10(-8) mol/L E-4021+10(-7) mol/L ACh -62.7+/-3.1%, P<0.05). In perfused kidneys, AM-induced vasorelaxation was also augmented by preincubation with E-4021 (10(-9) mol/L AM -15.4+/-0.6% versus 10(-8) mol/L E-4021+10(-9) mol/L AM -23.6+/-1.2%, P<0.01). AM significantly increased NO release from rat kidneys (DeltaNO: +11.3+/-0.8 fmol. min-1. g-1 kidney at 10(-9) mol/L AM), which was not affected by E-4021. E-4021 enhanced ACh-induced vasorelaxation (10(-9) mol/L ACh -9.7+/-1.7% versus 10(-8) mol/L E-4021+10(-9) mol/L ACh -18.8+/-2.9%, P<0.01) but did not affect ACh-induced NO release from the kidneys. In the aorta and the kidney, 10(-4) mol/L of NG-nitro-L-arginine methyl ester, an NO synthase inhibitor, and 10(-5) mol/L of methylene blue, a guanylate cyclase inhibitor, reduced the vasodilatory effect of AM. These results suggest that the NO-cGMP pathway is involved in the mechanism of AM-induced vasorelaxation, at least in the rat aorta and kidney.  (+info)

Adrenomedullin is upregulated in the heart and aorta during the early and late stages of sepsis. (2/693)

Although circulating levels of adrenomedullin (ADM), a newly reported vasodilatory peptide with 52 amino acid residues in the human and 50 amino acid residues in the rat, are elevated during the early and late stages of sepsis, ADM levels in cardiovascular tissues and its precise localization remain to be determined. To study this, rats were subjected to sepsis by cecal ligation and puncture (CLP), followed by administration of 3 ml/100 g b.wt. normal saline to these and sham-operated animals. The heart and thoracic aorta were harvested at 5 h (i.e. the early stage of sepsis) and 20 h (late sepsis) after CLP. Tissue levels of ADM were determined by radioimmunoassay. The localization of ADM in the left ventricle and thoracic aorta was examined by using immunohistochemistry and electron microscopy techniques. The results indicated that ADM levels in the heart and thoracic aorta increased significantly at 5 h after CLP and remained elevated at 20 h after the onset of sepsis. Immunohistochemistry findings showed that ADM immunoreaction products were localized in the cytoplasm of the cardiac myocytes and aortic endothelial cells. Using electron microscopy, ADM immunoreaction products were found in the cytoplasmic matrixes. The immunostainings were also associated with the outer membranes of mitochondria and vesicles of the myocytes as well as vascular endothelial cells. It appears that the cardiovascular tissues, among other organ systems, contribute to the increased levels of plasma ADM under those conditions. Since ADM is localized in different cell populations in the heart and the large blood vessel (i.e. myocytes versus vascular endothelial cells), this peptide may play a differential role in regulating cardiac and vascular functions during sepsis as an autocrine and/or paracrine mediator.  (+info)

Proadrenomedullin N-terminal 20 peptide hyperpolarizes the membrane by activating an inwardly rectifying K+ current in differentiated PC12 cells. (3/693)

The mechanism of proadrenomedullin N-terminal 20 peptide (PAMP)-induced inhibition of catecholamine release from adrenergic nerve was investigated in nerve growth factor-treated PC12 cells that have differentiated characteristics somewhat similar to noradrenergic neurons. The effect of PAMP on the excitability of these cells was investigated with the use of perforated whole-cell clamp. PAMP hyperpolarized the membrane by increasing a K+ conductance in a dose-dependent manner. The current-voltage relationship (I-V) relationship of the PAMP-induced K+ conductance exhibited inward-going rectification. The activation was abolished by microinjecting GDPbetaS into the cells or pretreating the cells with pertussis toxin. These results indicate that a pertussis toxin-sensitive G protein is involved in the signal transduction. The PAMP-induced activation of the K+ conductance was attenuated by microinjecting antibody against the carboxyl terminus of Galphai3, but it was not influenced by microinjecting antibody against the common carboxyl termini of Galphai1 and Galphai2, which indicated that the G protein coupling the PAMP receptor to the inwardly rectifying K+ current is Galphai3. The PAMP-induced hyperpolarization may inhibit the catecholamine release from the neurons by attenuating the action potential frequency.  (+info)

Coronary sinus adrenomedullin rises in response to myocardial injury. (4/693)

Human adrenomedullin (ADM), a peptide comprising 52 amino acids, is a circulating hormone with vasodilator properties. We have evaluated its release by the heart following ischaemic myocardial damage, as indicated by elevated levels of the cardiospecific protein troponin-T (Tn-T) during cardiopulmonary bypass. ADM (pg/ml) and Tn-T (ng/ml) were measured in coronary sinus blood before and after aortic cross-clamp and in venous blood 6 h after surgery in 22 coronary-bypass patients. Based on the pre- and post-clamp Tn-T levels in the coronary sinus, the patients were divided into group I (no change; n=10) and group II (two times increase; n=12). Baseline ADM (362.7+/-106.2 and 303+/-58.7 pg/ml in groups I and II respectively; means+/-S.D.) and Tn-T (0.66+/-0.14 and 0.57+/-0.13 ng/ml respectively) levels were similar in both groups. In group I, the post-clamp ADM (317.6+/-80.8 pg/ml) and Tn-T (0.68+/-0.15 ng/ml) levels did not change significantly. In group II, the post-clamp ADM levels rose significantly above the baseline, mimicking the change in Tn-T (ADM, 541.4+/-89.4 pg/ml; Tn-T, 1.37+/-0.31 ng/ml; P=0.009). After 6 h, the systemic Tn-T levels were similar in both groups (2. 09+/-0.44 and 1.95+/-0.52 ng/ml in groups I and II respectively). We suggest that: (1) minor degrees of myocardial ischaemic damage result in release of ADM by the heart, and (2) ADM may play a protective role in the myocardium during an ischaemic insult. This suggests a possible therapeutic role for ADM in the management of intra-operative myocardial ischaemia.  (+info)

Effects of adrenomedullin and PAMP on adrenal catecholamine release in dogs. (5/693)

We examined the effects of proadrenomedullin-derived peptides on the release of adrenal catecholamines in response to cholinergic stimuli in pentobarbital sodium-anesthetized dogs. Drugs were administered into the adrenal gland through the phrenicoabdominal artery. Splanchnic nerve stimulation (1, 2, and 3 Hz) and ACh injection (0.75, 1.5, and 3 microgram) produced frequency- or dose-dependent increases in adrenal catecholamine output. These responses were unaffected by infusion of adrenomedullin (1, 3, and 10 ng. kg-1. min-1) or its selective antagonist adrenomedullin-(22-52) (5, 15, and 50 ng. kg-1. min-1). Proadrenomedullin NH2-terminal 20 peptide (PAMP; 5, 15, and 50 ng. kg-1. min-1) suppressed both the splanchnic nerve stimulation- and ACh-induced increases in catecholamine output in a dose-dependent manner. PAMP also suppressed the catecholamine release responses to the nicotinic agonist 1, 1-dimethyl-4-phenylpiperazinium (0.5, 1, and 2 microgram) and to muscarine (0.5, 1, and 2 microgram), although the muscarine-induced response was relatively resistant to PAMP. These results suggest that PAMP, but not adrenomedullin, can act as an inhibitory regulator of adrenal catecholamine release in vivo.  (+info)

Hypoxia-induced adrenomedullin production in the kidney. (6/693)

BACKGROUND: Adrenomedullin (AM) is a newly discovered peptide that has a potent vasorelaxant activity. To investigate its potential roles in hypoxia-induced renal injury, we examined whether AM production in the kidney increased under hypoxic conditions. METHODS: The AM transcript levels in Madin-Darby canine kidney (MDCK) cells, rat vascular smooth muscle cells (VSMCs), and rat mesangial cells were assessed by Northern blot analyses under normoxic and hypoxic conditions. The AM peptide in culture media was measured by radioimmunoassay. The effects of hypoxia on accumulation of cAMP in VSMCs were also examined. The stability of AM transcripts under normoxic and hypoxic conditions was compared in the presence of actinomycin D. The effects of hypoxia on AM promoter activity was assessed by transient transfection assays using the AM promoter subcloned upstream of luciferase gene. RESULTS: The expression of AM transcripts increased significantly in MDCK cells, rat VSMCs, and rat mesangial cells under hypoxic conditions without changes in the stability of AM transcripts; however, the AM promoter activity under hypoxic was not elevated significantly. The accumulation of AM peptide in culture media also increased significantly under hypoxic conditions in MDCK cells (2.2 +/- 0.1 fmol/10(5) cells in normoxia vs. 3.5 +/- 0.3 fmol/10(5) cells in hypoxia, 6 hr after hypoxia induction, P < 0.001), and in rat VSMCs (5.5 +/- 0.3 fmol/10(5) cells in normoxia vs. 7.8 +/- 0.4 fmol/10(5) cells in hypoxia, 8 hr after hypoxia induction, P < 0.01). Under hypoxic conditions, cAMP levels in rat VSMCs increased significantly compared with those under normoxic conditions (13.3 +/- 1.4 pmol/well vs. 4.6 +/- 0.4 pmol/well, P < 0.01). CONCLUSIONS: Renal parenchymal cells as well as renal vessels may produce AM under hypoxic conditions.  (+info)

Characterization of receptors for calcitonin gene-related peptide and adrenomedullin on the guinea-pig vas deferens. (7/693)

1. The receptors which mediate the effects of calcitonin gene-related peptide (CGRP), amylin and adrenomedullin on the guinea-pig vas deferens have been investigated. 2. All three peptides cause concentration dependant inhibitions of the electrically stimulated twitch response (pD2s for CGRP, amylin and adrenomedullin of 7.90+/-0.11, 7.70+/-0.19 and 7.25+/-0.10 respectively). 3. CGRP8-37 (1 microM) and AC187 (10 microM) showed little antagonist activity against adrenomedullin. 4. Adrenomedullin22-52 by itself inhibited the electrically stimulated contractions of the vas deferens and also antagonized the responses to CGRP, amylin and adrenomedullin. 5. [125I]-adrenomedullin labelled a single population of binding sites in vas deferens membranes with a pIC50 of 8.91 and a capacity of 643 fmol mg(-1). Its selectivity profile was adrenomedullin> AC187>CGRP=amylin. It was clearly distinct from a site labelled by [125I]-CGRP (pIC50=8.73, capacity=114 fmol mg(-1), selectivity CGRP>amylin=AC187>adrenomedullin). [125I]-amylin bound to two sites with a total capacity of 882 fmol mg(-1). 6. Although CGRP has been shown to act at a CGRP2 receptor on the vas deferens with low sensitivity to CGRP8-37, this antagonist displaced [125I]-CGRP with high affinity from vas deferens membranes. This affinity was unaltered by increasing the temperature from 4 degrees C to 25 degrees C, suggesting the anomalous behaviour of CGRP8-37 is not due to temperature differences between binding and functional assays.  (+info)

Central adrenomedullin augments the baroreceptor reflex in conscious rabbits. (8/693)

We examined the roles of central adrenomedullin, proadrenomedullin N-terminal 20 peptide (PAMP), and calcitonin gene-related peptide (CGRP) on the baroreceptor reflex in conscious rabbits. Intracerebroventricular injection of adrenomedullin (0.2 and 1 nmol/80 microL) elicited dose-related increases in arterial pressure and renal sympathetic nerve activity. On the other hand, a subpressor dose of intracerebroventricular infusion of adrenomedullin (1 nmol/300 microL per hour) caused significant increases in baroreflex sensitivities assessed by renal sympathetic nerve activity and heart rate compared with vehicle infusion (Gmax; -14.9+/-1.7 versus -8.0+/-0.7%/mm Hg, P<0.01, and -8.1+/-0.8 versus -5.1+/-0.5 bpm/mm Hg, P<0.01, respectively). Intracerebroventricular infusion of CGRP (1 nmol/300 microL per hour), which is structurally homologous to adrenomedullin, also enhanced the baroreflex controls of renal sympathetic nerve activity and heart rate. However, the intracerebroventricular infusion of PAMP (30 nmol/300 microL per hour) failed to alter the baseline levels of arterial pressure and baroreflex sensitivities. These results suggest that central adrenomedullin and CGRP, but not PAMP, participate in cardiovascular regulation to augment the baroreflex controls of renal sympathetic nerve activity and heart rate in conscious rabbits.  (+info)

Plasma adrenomedullin as an indicator of prognosis after acute myocardial infarction | HeartPlasma adrenomedullin as an indicator of prognosis after acute myocardial infarction | Heart
We showed that plasma adrenomedullin concentrations on day 2 were markedly increased in patients with heart failure (Killip class II or more) after myocardial infarction and were negatively correlated with left ventricular ejection fraction; that among the non-invasive variables, only plasma adrenomedullin was an independent predictor of mortality by multivariate analysis; and that, using Kaplan-Meier survival curves, patients with plasma adrenomedullin values above the median had a significantly greater mortality than those with values below the median.. Earlier studies have shown that adrenomedullin is produced mainly by endothelial cells and by vascular smooth muscle cells regulating vascular tone.1 4 18-20 More recently, the failing ventricle has also been shown to secrete adrenomedullin into plasma.11 12 Adrenomedullin synthesis is promoted in vitro by a variety of cytokines, such as interleukin-1β and tumour necrosis factor α,18 19 both of which increase in parallel with myocardial ...
http://heart.bmj.com/content/81/5/483
PAMP - proadrenomedullin N-terminal 20 peptide | AcronymAtticPAMP - proadrenomedullin N-terminal 20 peptide | AcronymAttic
How is proadrenomedullin N-terminal 20 peptide abbreviated? PAMP stands for proadrenomedullin N-terminal 20 peptide. PAMP is defined as proadrenomedullin N-terminal 20 peptide rarely.
https://www.acronymattic.com/proadrenomedullin-N_terminal-20-peptide-
Effect of prolonged dynamic exercise on plasma adrenomedullin concentration in healthy young men.
The aim of the study was to find out whether prolonged exercise influences plasma adrenomedullin (ADM) concentration and whether it is related to the hormonal, metabolic and cardiovascular changes. Eighteen healthy subjects (age 25+/-1 yrs) were subm
http://www.biomedsearch.com/nih/Effect-prolonged-dynamic-exercise-plasma/17229982.html
Modulation of cytokine responses by adrenomedullin and adrenomedullin binding protein-1 in macrophages: a novel pathway in...Modulation of cytokine responses by adrenomedullin and adrenomedullin binding protein-1 in macrophages: a novel pathway in...
4. The production of interleukin-6 is mediated by p38-mitogen-activated protein kinase (MAPK), p42/44-MAPK, protein kinase C, and protein kinase K, whereas that of interleukin-10 is mediated by p38-MAPK and protein kinase K ...
http://www.hkmj.org/abstracts/v21%20Suppl%204n/39.htm
Therapeutic efficacy of intra-articular adrenomedullin injection in antigen-induced arthritis in rabbits | Arthritis Research &...Therapeutic efficacy of intra-articular adrenomedullin injection in antigen-induced arthritis in rabbits | Arthritis Research &...
Adrenomedullin is a potent vasodilatory and hypotensive peptide as well as an endogenous immunomodulatory factor with predominantly anti-inflammatory effects. The purpose of the present study was to evaluate the therapeutic effects of adrenomedullin in rabbits with antigen-induced arthritis, an experimental model of rheumatoid arthritis. Following the induction of arthritis in both knee joints by ovalbumin injection into the joint spaces of pre-immunized rabbits, increasing daily doses of adrenomedullin were injected into the knee joint spaces or saline was injected into the contralateral knee joint spaces as the control. For time-course experiments, adrenomedullin and saline were injected into the knee joint spaces daily for 7 days and 20 days. The degree of joint swelling and the histological change in the knee joints injected with adrenomedullin were compared with the control knee joints. Histological evaluation of the infrapatellar fat pads and synovial tissue was performed. TNFα, IL-6, vascular
https://arthritis-research.biomedcentral.com/articles/10.1186/ar2550/email/correspondent/c1/new
Plus itPlus it
There were three main findings in our study. First, plasma MR-proADM concentration was elevated in type 2 diabetic subjects with preserved renal function. This was further accentuated in the presence of established diabetic nephropathy. Second, metabolic and inflammatory factors, namely insulin resistance, LDL cholesterol, adiponectin, and hsCRP, appeared to be significant determinants of plasma MR-proADM concentrations. Third, MR-proADM was well correlated with measurement of resting, unprovoked microcirculatory blood flow, suggesting that it may be one of the determinants of basal vascular perfusion in subjects with type 2 diabetes.. The first finding was interesting because it clarified the relationship between plasma adrenomedullin concentrations and type 2 diabetes. Our data suggested that MR-proADM was mildly elevated in subjects with uncomplicated type 2 diabetes (Fig. 1). However, in the presence of diabetic nephropathy, plasma MR-proADM became markedly deranged (consistent with ...
https://care.diabetesjournals.org/content/30/6/1513
Plasma Concentrations of the Vasoactive Peptide Fragments Mid-Regional Pro-Adrenomedullin, C-Terminal Pro-Endothelin 1 and...Plasma Concentrations of the Vasoactive Peptide Fragments Mid-Regional Pro-Adrenomedullin, C-Terminal Pro-Endothelin 1 and...
Plasma Concentrations of the Vasoactive Peptide Fragments Mid-Regional Pro-Adrenomedullin, C-Terminal Pro-Endothelin 1 and Copeptin in Hemodialysis Patients: Associated Factors and Prediction of ...
https://bibliographie.uni-tuebingen.de/xmlui/handle/10900/55011
Mid-regional pro-adrenomedullin and copeptin to predict short-term pro | COPDMid-regional pro-adrenomedullin and copeptin to predict short-term pro | COPD
Mid-regional pro-adrenomedullin and copeptin to predict short-term prognosis of COPD exacerbations: a multicenter prospective blinded study Martin Dres,1,2 Pierre Hausfater,3,4 Frantz Foissac,5,6 Maguy Bernard,7 Luc-Marie Joly,8 Mustapha Sebbane,9 Anne-Laure Philippon,3,4 Cédric Gil-Jardiné,10 Jeannot Schmidt,11 Maxime Maignan,12 Jean-Marc Treluyer,13 Nicolas Roche14,15 On behalf of the UTAPE Study Investigators and Scientific Committee 1Pulmonary and Critical Care Department, Pitié-Salpêtrière Hospital, AP-HP, 2UMRS1158: Clinical and Experimental Respiratory Neurophysiology, Paris 6 University, 3Emergency Department, Hôpital Pitié-Salpêtrière, AP-HP, 4Sorbonne Universités UPMC Univ-Paris06, GRC-14 BIOSFAST, 5Clinical Research Department, Necker Cochin Hospital, AP-HP, 6EA 7323, Sorbonne Paris-Cité, 7Biochemistry Department, Pitié-Salpêtrière Hospital, AP-HP, Paris, 8Emergency Department, Charles Nicolle
https://www.dovepress.com/mid-regional-pro-adrenomedullin-and-copeptin-to-predict-short-term-pro-peer-reviewed-article-COPD
Haemodynamic effects of adrenomedullin in human resistance and capacitance vessels - Enlighten: PublicationsHaemodynamic effects of adrenomedullin in human resistance and capacitance vessels - Enlighten: Publications
Aims The haemodynamic effects of adrenomedullin and calcitonin gene-related peptide (CGRP) were studied in resistance and capacitance vessels of healthy volunteers.. Methods Adrenomedullin and CGRP were infused into the brachial artery of eight healthy subjects on two separate occasions at doses between 0.3-30 pmol min−1. Forearm blood flow was measured using venous occlusion plethysmography. Venodilatation to adrenomedullin and CGRP was assessed in a further eight subjects by infusing the peptides at doses between 0.3-10 pmol min−1 into a dorsal hand vein preconstricted with noradrenaline. Venodilator responses were measured as percentage reduction in noradrenaline preconstriction.. Results Adrenomedullin and CGRP at a dose of 30 pmol min−1, produced an increase in forearm blood flow of 288±42% and 252±30% respectively (mean±s.e. mean, P,0.001). At doses between 3 and 10 pmol min−1 adrenomedullin was significantly more potent than CGRP. The vasodilatation to both peptides was of ...
http://eprints.gla.ac.uk/64078/
Plus itPlus it
I have read with great interest the article by Harmancey et al. (1) on inhibition of adipogenesis by adrenomedullin. Previous studies, including ours (2-4), have shown that adrenomedullin is produced and secreted by adipocytes and adipose tissues, whereas the reported effects of adrenomedullin on lipolysis are conflicting (5,6). Harmancey et al. (1) have clearly shown inhibition of adipogenesis by adrenomedullin using small interfering RNA technology. However, I have several concerns regarding this article. First, the concentration of exogenously added adrenomedullin (100 nmol/l) was very high in the experiment on the inhibitory effects on adipogenesis (Fig. 1 in article). The adrenomedullin concentrations in the medium of cultured adipocytes rarely exceed 1 nmol/l (2,4). Second, the authors used 3T3-F442A preadipocytes but not adipocytes in the transfection study (Fig. 6 in article). There is a considerable difference in the adrenomedullin promoter activity between preadipocytes and adipocytes, ...
http://diabetes.diabetesjournals.org/content/56/9/e15
Adrenomedullin refines mortality prediction by the BODE index in COPD: the BODE-A index.<...
TY - JOUR. T1 - Adrenomedullin refines mortality prediction by the BODE index in COPD: the BODE-A index.. AU - Stolz, D.. AU - Kostikas, K.. AU - Blasi, F.. AU - Boersma, W.. AU - Milenkovic, B.. AU - Lacoma, A.. AU - Louis, R.. AU - Aerts, J.G.. AU - Welte, T.. AU - Torres, A.. AU - Rohde, G.G.. AU - Boeck, L.. AU - Rakic, J.. AU - Scherr, A.. AU - Hertel, S.. AU - Giersdorf, S.. AU - Tamm, M.. PY - 2014/1/1. Y1 - 2014/1/1. N2 - The BODE index is well-validated for mortality prediction in COPD. of plasma proadrenomedullin, a surrogate for mature adrenomedullin, predicted 2-year mortality among inpatients with COPD exacerbation.We accuracy of initial proadrenomedullin level, BODE, and BODE components, combined, in predicting 1-year or 2-year all-cause mortality in a multinational observational cohort with stable, moderate to very severe COPD.Proadrenomedullin was significantly associated (P,0.001) with 1- mortality (4.7%) and 2-year mortality (7.8%), and comparably predictive regarding both (C ...
https://cris.maastrichtuniversity.nl/en/publications/adrenomedullin-refines-mortality-prediction-by-the-bode-index-in-
Adrenomedullin<...
TY - CHAP. T1 - Adrenomedullin. AU - Abel, Peter. AU - Rorabaugh, Boyd. PY - 2007/1/1. Y1 - 2007/1/1. N2 - Adrenomedullin is a member of the calcitonin family of peptides. It is produced by vascular smooth muscle cells, vascular endothelial cells, cardiomyocytes, adrenal chromaffin cells, macrophages, bronchial epithelium, and many other cell types. This peptide is a potent vasodilator in most vascular beds and has been implicated in the regulation of blood pressure, ..... AB - Adrenomedullin is a member of the calcitonin family of peptides. It is produced by vascular smooth muscle cells, vascular endothelial cells, cardiomyocytes, adrenal chromaffin cells, macrophages, bronchial epithelium, and many other cell types. This peptide is a potent vasodilator in most vascular beds and has been implicated in the regulation of blood pressure, ..... UR - http://www.scopus.com/inward/record.url?scp=84884021496&partnerID=8YFLogxK. UR - ...
https://creighton.pure.elsevier.com/en/publications/adrenomedullin
Application of MR-ProADM to predict prevention of hospitalisation, derived from a multi-centre study | Critical Care | Full TextApplication of MR-ProADM to predict prevention of hospitalisation, derived from a multi-centre study | Critical Care | Full Text
We read with interest the paper presented by Saeed et al [1], The early identification of disease progression in patients with suspected infection presenting to the emergency department: a multi-centre derivation and validation study. We retrospectively applied the cut-offs for mid-regional pro-adrenomedullin (MR-proADM) and C-reactive protein (CRP) derived in this study to the cohort used in our paper, Can mid-regional pro-adrenomedullin (MR-proADM) increase the prognostic accuracy of NEWS in predicting deterioration in patients admitted to hospital with mild to moderately severe illness? A prospective single-centre observational study [2] to see if we could replicate the sensitivity and specificity obtained for predicting avoidance of hospitalisation, defined as a discharge to community care within 24 h of presentation. ...
https://ccforum.biomedcentral.com/articles/10.1186/s13054-019-2402-0
Protective Effects of Endogenous Adrenomedullin on Cardiac Hypertrophy, Fibrosis, and Renal Damage | CirculationProtective Effects of Endogenous Adrenomedullin on Cardiac Hypertrophy, Fibrosis, and Renal Damage | Circulation
Using AM knockout mice, we have been able to make 3 key observations: (1) that reduced expression of endogenous AM exacerbates the cardiac hypertrophy and fibrosis caused by pressure overload (aortic constriction) or Ang II infusion, leading to diminished cardiac function; (2) that reduced AM expression exacerbates the renal damage caused by Ang II infusion; and (3) that AM suppresses development of cardiac hypertrophy via suppression of ERK activation.. In the present study, we found that although the respective heart, kidney, and body weights were similar in AM+/− and wild-type mice, cardiac and renal expression of AM in AM+/− mice was only approximately half that seen in wild-type mice. Moreover, AM+/− mice exhibited wider left ventricular diastolic diameter than wild-type mice, even under basal conditions, which suggests that AM is necessary for proper development of the heart.. The differences between AM+/− and wild-type mice became much more apparent when stress was applied to the ...
http://circ.ahajournals.org/content/109/14/1789
Adrenomedullin promotes formation of xenografted endometrial t...Adrenomedullin promotes formation of xenografted endometrial t...
Adrenomedullin promotes formation of xenografted endometrial tumors by stimulation of autocrine growth and angiogenesis.: The angiogenic peptide adrenomedullin
https://www.mysciencework.com/publication/show/adrenomedullin-promotes-formation-xenografted-endometrial-tumors-stimulation-autocrine-growth-angiogenesis-6b2f9576
adrenomedullin - oi
A hypotensive vasodilator peptide (ADM, 52 aa) found in blood in significant amounts. It has diuretic and natriuretic effects on the kidney where it inhibits aldosterone secretion and in the pituitary it inhibits basal ACTH secretion. Together with adrenomedullin-binding protein-1 (AMBP-1) it has been shown to reduce tissue damage in inflammation and appears to protect cells against oxidative stress. Adrenomedullin-2 (intermedin, 148 aa) may regulate gastrointestinal and cardiovascular activities through a cAMP-dependent pathway. The receptor is G-protein coupled. See proadrenomedullin. ...
http://oxfordindex.oup.com/view/10.1093/oi/authority.20110803095352399
The effect of adrenomedullin and proadrenomedullin N- terminal 20 peptide on angiotensin II induced vascular smooth muscle cell...The effect of adrenomedullin and proadrenomedullin N- terminal 20 peptide on angiotensin II induced vascular smooth muscle cell...
aorta tissues and then cultured. In vitro cultured VSMCs were stimulated with Ang II (10†8 mol/l) followed by various doses of PAMP or ADM (10†9, 10†8, or 10†7 mol/l). Cell proliferation as assessed by 3H†TdR incorporation. Protein kinase C (PKC) activity was measured by counting γ†32P radioactivity with liquid scintillation. In a separate cohort, in vitro cultured rat aortic vessels were treated with different doses of Ang II or PAMP (10†9, 10†8, or 10†7 mol/l). Cellular and secreted levels of PAMP, ADM and Ang II were measured using radioimmunoassay in the tissues and intubation mediums, respectively.. Ang II (10†8 mol/l) treatment significantly increased both 3H†TdR incorporation and PKC activity in VSMCs (by 2.68 and 1.02†fold, respectively; both P,0.01 vs. the control). However, Ang II†induced elevation of 3H†TdR incorporation, and PKC activity was significantly inhibited by various doses of ADM and PAMP (all P,0.01 ...
https://www.peptide.com/2016/04/22/the-effect-of-adrenomedullin-and-proadrenomedullin-n-terminal-20-peptide-on-angiotensin-ii-induced-vascular-smooth-muscle-cell-proliferation/
Mid-regional pro-adrenomedullin and ST2 in heart failure: Contributions to diagnosis and prognosis
Monitoring of sST2 values through serial measurements appears to be particularly useful, increasing the prognostic power of this biomarker.39 Bayes-Genis et al.40 studied a small group of patients with acute HF and measured their sST2 values at discharge and two weeks later. Patients with a greater decrease in sST2 two weeks after discharge had a better prognosis.40 Another study measured sST2 at admission in the ED and 48 hours later, concluding that sST2 levels clearly separated those who survived from those who did not.40 Likewise, the percentage of sST2 decrease predicted long term mortality.41. It can be concluded that sST2 is a good prognostic marker, both short- and long-term, in patients hospitalized for acute HF. Also, the addition of sST2 to natriuretic peptides is superior to the use of natriuretic peptides alone. It is important to emphasize that repeated monitoring of sST2 levels is more useful than a single measurement, and its low biological variability increases its potential for ...
http://elsevier.pt/en/revistas/revista-portuguesa-cardiologia-english-edition--434/artigo/mid-regional-pro-adrenomedullin-st2-in-heart-failure-contributions-diagnosis-S0870255116302323
View source for Adrenomedullin - wikidocView source for Adrenomedullin - wikidoc
Infobox_gene}} Adrenomedullin (ADM or AM) is a [[vasodilator]] [[peptide hormone]] of uncertain significance in human health and disease. It was initially isolated in 1993 from a [[pheochromyctoma,pheochromocytoma]], a tumor of the [[adrenal medulla]]: hence the name.,ref name=Kitamura_1998>{{cite journal , vauthors = Kitamura K, Kato J, Kawamoto M, Tanaka M, Chino N, Kangawa K, Eto T , title = The intermediate form of glycine-extended adrenomedullin is the major circulating molecular form in human plasma , journal = Biochem. Biophys. Res. Commun. , volume = 244 , issue = 2 , pages = 551-5 ,date=March 1998 , pmid = 9514956 , doi = 10.1006/bbrc.1998.8310 }},/ref> In humans ADM is encoded by the ADM [[gene]]. ADM is a peptide expressed by all tissues, and found in the circulation. A similar peptide named adreomedullin2 was reported in rats in 2004 which exhibits a similar function.,ref name=pmid15321737>{{cite journal , vauthors = Fujisawa Y, Nagai Y, Miyatake A, Takei Y, ...
http://wikidoc.org/index.php?title=Adrenomedullin&action=edit
Adrenomedullin Reduces Endothelial Hyperpermeability | Circulation ResearchAdrenomedullin Reduces Endothelial Hyperpermeability | Circulation Research
Recent studies have demonstrated elevated plasma levels of ADM in vertebrates with a systemic inflammatory response.15-19⇓⇓⇓⇓ However, the role of ADM in the complex and dynamic disease process of sepsis is still largely undefined. On the one hand, the high ADM plasma levels observed in septic humans may contribute to hypotension and hyperdynamic circulatory response in sepsis, thereby contributing to disease progress.18 On the other hand, transgenic mice overexpressing ADM in their vasculature turned out to be resistant against lipopolysaccharide-induced shock, suggesting a rather beneficial effect of elevated ADM levels in sepsis.26. Considering that endothelial hyperpermeability is the hallmark of an inflammatory reaction1,2⇓ and that mice lacking a functional ADM gene displayed an extreme hydrops fetalis,27 we tested the hypothesis that elevated ADM levels stabilized endothelial barrier function, thereby acting as a protective peptide in the systemic inflammatory response. Our ...
http://circres.ahajournals.org/content/91/7/618
No relation between biomarkers at age 47-49 and aortic diameter after 14-19 years of follow-up - a population-based study |...No relation between biomarkers at age 47-49 and aortic diameter after 14-19 years of follow-up - a population-based study |...
BACKGROUND: Biomarkers reflecting diverse pathophysiological pathways may play an important role in the pathogenesis of abdominal aortic aneurysm (aortic diameter ≥30 mm, AAA), levels of many biomarkers are elevated and correlated to aortic diameter among 65-year-old men undergoing ultrasound (US) screening for AAA.. PROBANDS AND METHODS: To evaluate potential relationships between biomarkers and aortic dilatation after long-term follow-up, levels of C-reactive protein (CRP), proneurotensin (PNT), copeptin (CPT), lipoprotein-associated phospholipase 2 (Lp-PLA2), cystatin C (Cyst C), midregional proatrial natriuretic peptide (MR-proANP), and midregional proadrenomedullin (MR-proADM) were measured in 117 subjects (114 [97 %] men) aged 47-49 in a prospective population-based cohort study, and related to aortic diameter at US examination of the aorta after 14-19 years of follow-up.. RESULTS: Biomarker levels at baseline did not correlate with aortic diameter after 14-19 years of follow up (CRP [r ...
https://www.ludc.lu.se/j-gustav-smith-pi-md-phd/publication/89b3ddb7-71f7-4d56-b910-c44767f5c7c6
SISA - Società Italiana per lo Studio dellAterosclerosi - Novel and conventional biomarkers for prediction of incident...
CONTEXT: Prior studies have demonstrated conflicting results regarding how much information novel biomarkers add to cardiovascular risk assessment. OBJECTIVE: To evaluate the utility of contemporary biomarkers for predicting cardiovascular risk when added to conventional risk factors. DESIGN, SETTING, AND PARTICIPANTS: Cohort study of 5067 participants (mean age, 58 years; 60% women) without cardiovascular disease from Malmö, Sweden, who attended a baseline examination between 1991 and 1994. Participants underwent measurement of C-reactive protein (CRP), cystatin C, lipoprotein-associated phospholipase 2, midregional proadrenomedullin (MR-proADM), midregional proatrial natriuretic peptide, and N-terminal pro-B-type natriuretic peptide (N-BNP) and underwent follow-up until 2006 using the Swedish national hospital discharge and cause-of-death registers and the Stroke in Malmö register for first cardiovascular events (myocardial infarction, stroke, coronary death). MAIN OUTCOME MEASURES: ...
http://www.sisa.it/index.php?class=Comp&className=Content&op=Show¶m=cid,104,preview,0
adrenomedullin 2/intermedin | Ligand page | IUPHAR/BPS Guide to PHARMACOLOGYadrenomedullin 2/intermedin | Ligand page | IUPHAR/BPS Guide to PHARMACOLOGY
The IUPHAR/BPS Guide to Pharmacology. adrenomedullin 2/intermedin ligand page. Quantitative data and detailed annnotation of the targets of licensed and experimental drugs.
https://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=684
adrenomedullin 2/intermedin | Ligand page | IUPHAR/BPS Guide to PHARMACOLOGYadrenomedullin 2/intermedin | Ligand page | IUPHAR/BPS Guide to PHARMACOLOGY
The IUPHAR/BPS Guide to Pharmacology. adrenomedullin 2/intermedin ligand page. Quantitative data and detailed annnotation of the targets of licensed and experimental drugs.
https://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=3591
KAKEN - Research Projects | Effect of adrenomedullin on excitation-contraction coupling and abnormal automaticity in excised...KAKEN - Research Projects | Effect of adrenomedullin on excitation-contraction coupling and abnormal automaticity in excised...
Principal Investigator：IMANISHI Sunao, Project Period (FY)：1997 - 1998, Research Category：Grant-in-Aid for Scientific Research (C), Section：一般, Research Field：Circulatory organs internal medicine
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09670767/
KAKEN - Research Projects | The effect of adrenomedullin on Th17 cells in periodontal disease. (KAKENHI-PROJECT-25893158)KAKEN - Research Projects | The effect of adrenomedullin on Th17 cells in periodontal disease. (KAKENHI-PROJECT-25893158)
Principal Investigator：HOSOKAWA Ikuko, Project Period (FY)：2013-08-30 - 2015-03-31, Research Category：Grant-in-Aid for Research Activity start-up, Research Field：Periodontology
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-25893158/
Adrenomedullin/ADM Mouse anti-Human, Clone: OTI8A1, Novus Biologicals 100 | Fisher ScientificAdrenomedullin/ADM Mouse anti-Human, Clone: OTI8A1, Novus Biologicals 100 | Fisher Scientific
Shop a large selection of products and learn more about Adrenomedullin/ADM Mouse anti-Human, Clone: OTI8A1, Novus Biologicals. 100 μg Unconjugated.
https://www.fishersci.com/shop/products/adrenomedullin-adm-100-ug/nbp270100
Anti-Adrenomedullin [HTA 91a/G2] | Monoclonal Antibodies - XimbioAnti-Adrenomedullin [HTA 91a/G2] | Monoclonal Antibodies - Ximbio
Adrenomedullin is a member of the calcitonin family of peptides and functions as a vasodilator. Adrenomedullin may also function in
https://ximbio.com/reagent/151264/anti-adrenomedullin-hta-91ag2
Evaluation of adrenomedullin and endothelin-1: are they factors in the adaptation of maternal vascular system in normotensive...
INTRODUCTION: The aim of our study was to analyse the role of adrenomedullin (AM) and endothelin-1 (ET-1) in the adaptation of the maternal vascular system in normotensive pregnancy. METHODS: Twenty-eight pregnant women, who were normotensive through
http://www.biomedsearch.com/nih/Evaluation-adrenomedullin-endothelin-1-Are/18463805.html
Reliability of Pro-adrenomedullin and Interleukin 1β in Predicting Severity of Community-Acquired Pneumonia in Pediatric...Reliability of Pro-adrenomedullin and Interleukin 1β in Predicting Severity of Community-Acquired Pneumonia in Pediatric...
Serum Pro-ADM and IL-1β levels may offer additional risk/severity stratification in children with CAP. In addition, they may be helpful in predicting the development of complications, requirements for ntensive care unit admission, and intervention procedures.
https://pubmed.ncbi.nlm.nih.gov/29531001/
Antioxidative effects of adrenomedullin and vascular endotheli...Antioxidative effects of adrenomedullin and vascular endotheli...
Antioxidative effects of adrenomedullin and vascular endothelial growth factor on lung injury induced by skeletal muscle ischemia-reperfusion.: These findings i
https://www.mysciencework.com/publication/show/antioxidative-effects-adrenomedullin-vascular-endothelial-growth-factor-lung-injury-induced-skeletal-muscle-ischemia-re-0a6a6400
Adrenomedullin in synovial fluids from patients with rheumatoid arthritis inhibits interleukin 6 production from synoviocytes |...Adrenomedullin in synovial fluids from patients with rheumatoid arthritis inhibits interleukin 6 production from synoviocytes |...
Adrenomedullin in synovial fluids from patients with rheumatoid arthritis inhibits interleukin 6 production from synoviocytes ...
https://ard.bmj.com/content/62/1/82.altmetrics
Adrenomedullin抗体|Abcam中国|Anti-Adrenomedullin抗体(ab125409)Adrenomedullin抗体|Abcam中国|Anti-Adrenomedullin抗体(ab125409)
Adrenomedullin兔多克隆抗体(ab125409)可与人样本反应并经WB实验严格验证。中国75%以上现货，所有产品均提供质保服务，可通过电话、电邮或微信获得本地专属技术支持。
http://www.abcam.cn/adrenomedullin-antibody-ab125409.html
Most recent papers with the keyword Acquired pneumonia | Read by QxMDMost recent papers with the keyword Acquired pneumonia | Read by QxMD
Acute dyspnea is a common chief complaint among patients who visit an emergency room and presents diagnostic challenges for clinicians in both identifying the etiology and determining the clinical severity. The study of biomarkers in the prognostication and risk stratification of these patients has been increasing, including the investigation of the prognostic value for mid-regional pro-adrenomedullin (MR-proADM). Areas Covered: In this review, the authors cover what is known about MR-proADM testing in patients presenting with acute dyspnea and the supporting evidence of its prognostic value in common conditions in medical patients with acute dyspnea, including acute heart failure, community acquired pneumonia, acute exacerbation of chronic obstructive pulmonary disease, and acute pulmonary embolism ...
https://www.readbyqxmd.com/keyword/85112
Conference Highlights: The AHA 2008 Annual Meeting | Physicians WeeklyConference Highlights: The AHA 2008 Annual Meeting | Physicians Weekly
The Particulars: Shortness of breath is a common patient symptom that presents in the ED but may be due to several causes, including asthma, respiratory infections, and congestive heart failure. The BACH Multinational Trial assessed Mid-Regional pro Adrenomedullin MR-proADM, a new blood test recently approved for use in Europe. It indirectly measures adrenomedullin, a hormone that affects blood vessel dilation and is associated with cardiac and infectious disease.. Data Breakdown: The trial was a prospective, 15-center, international multiple serum biomarker study of 1,641 patients presenting to the ED with shortness of breath. It compared the B-Natriuretic peptide (BNP) and N-terminal pro-B-type natriuretic peptide (NTproBNP) tests to MR-proADM. Researchers found that 34.6% of patients had a diagnosis of heart failure, of which 11.4% died within 90 days. For all 1,641 enrolled patients, the prognostic accuracy of MRproADM was 73.1% compared with a 60.6% rate for BNP and a 63.0% rate for ...
https://www.physiciansweekly.com/conference-highlights-the-aha-2008-annual-meeting/
IJMS | Free Full-Text | Immune-Response Patterns and Next Generation Sequencing Diagnostics for the Detection of Mycoses in...IJMS | Free Full-Text | Immune-Response Patterns and Next Generation Sequencing Diagnostics for the Detection of Mycoses in...
Fungi are of increasing importance in sepsis. However, culture-based diagnostic procedures are associated with relevant weaknesses. Therefore, culture- and next-generation sequencing (NGS)-based fungal findings as well as corresponding plasma levels of β-d-glucan, interferon gamma (INF-γ), tumor necrosis factor alpha (TNF-α), interleukin (IL)-2, -4, -6, -10, -17A, and mid-regional proadrenomedullin (MR-proADM) were evaluated in 50 septic patients at six consecutive time points within 28 days after sepsis onset. Furthermore, immune-response patterns during infections with Candida spp. were studied in a reconstituted human epithelium model. In total, 22% (n = 11) of patients suffered from a fungal infection. An NGS-based diagnostic approach appeared to be suitable for the identification of fungal pathogens in patients suffering from fungemia as well as in patients with negative blood cultures. Moreover, MR-proADM and IL-17A in plasma proved suitable for the identification of patients with a fungal
http://www.mdpi.com/1422-0067/18/8/1796
MR-proADM in the ED - B·R·A·H·M·S MR-proADMMR-proADM in the ED - B·R·A·H·M·S MR-proADM
Patient subgroups with high MR-proADM concentrations (≥ 1.54 nmol/L) and low biomarker (PCT , 0.25 ng/mL, lactate , 2.0 mmol/L or CRP , 67 mg/L) or clinical score (SOFA , 2 points, qSOFA , 2 points, NEWS , 4 points or CRB-65 , 2 points) values were characterized by a significantly longer length of hospitalization (p , 0.001), rate of ICU admission (p , 0.001), elevated mortality risk (e.g. SOFA, qSOFA and NEWS HR [95%CI], 45.5 [10.0-207.6], 23.4 [11.1-49.3] and 32.6 [9.4-113.6], respectively) and a greater number of disease progression events (p , 0.001), compared to similar subgroups with low MR-proADM concentrations (, 1.54 nmol/L ...
https://www.mrproadm.com/sepsis-ed/mr-proadm-ed.html
Adrenomedullin, a new peptide, in patients with insulinoma. | Sigma-AldrichAdrenomedullin, a new peptide, in patients with insulinoma. | Sigma-Aldrich
Sigma-Aldrich offers abstracts and full-text articles by [C Letizia, G Tamburrano, P Alo, A Paoloni, C Caliumi, E Marinoni, R di Iorio, E dErasmo].
https://www.sigmaaldrich.com/catalog/papers/11331218
Most ADM-201 Reliable Questions - ADM-201 Premium Exam, Reliable ADM-201 Exam Sample - Cuzco-Peru
ADM-201 Test Simulates: Salesforce Certified Administrator & ADM-201 Study Guide, Salesforce ADM-201 Most Reliable Questions Besides, our aftersales services also make us irreplaceable compared to peers, {{sitename}} delivers up to date ADM-201 exam products and modify them time to time, After you pay for the dumps, you will receive an email attached with ADM-201 exam dumps download which is very easy to download, and you can start the learning, Salesforce ADM-201 Most Reliable Questions The population in the world is growing constantly, so the competition is more radical for anyone who wants to be successful in their career.
http://mail.cuzco-peru.com/test-Most--Reliable-Questions-840505/ADM-201-exam.html
ADM5 Gene - GeneCards | ADM5 Protein | ADM5 AntibodyADM5 Gene - GeneCards | ADM5 Protein | ADM5 Antibody
Complete information for ADM5 gene (Protein Coding), Adrenomedullin 5 (Putative), including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
http://www.genecards.org/cgi-bin/carddisp.pl?gene=ADM5
ADM-201 Best Study Material, Actual ADM-201 Test Pdf | Test ADM-201 Dates - FastrackidsADM-201 Best Study Material, Actual ADM-201 Test Pdf | Test ADM-201 Dates - Fastrackids
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https://www.fastrackids.com/example-Best-Study-Material-840505/ADM-201-pdf/
GPR182 - Википедија, слободна енциклопедијаGPR182 - Википедија, слободна енциклопедија
GPR182 (ili G protein spregnuti receptor 182) je ljudski gen (i asocirani protein) koji je orfan GPCR.[1] Kad je ovaj gen bio kloniran prvi put, pretpostavljeno je da kodira adrenomedulin receptor.[2] Međutim kad je korespondirajući protein izražen, utvrđeno je da ne proizvodi respons na adrenomedulin (ADM).[3] Naknadno je bilo pokazano da jedan drugi GPCR receptor, CALCRL u kompleksu sa RAMP2 može da funkcioniše kao ADM receptor.[4] ...
https://sr.wikipedia.org/wiki/GPR182
ADM in Ingredients (World)ADM in Ingredients (World)
ADM is a global supplier of ingredients derived from agricultural sources and its portfolio includes both commodity-style basics as well as more highly
https://marketpublishers.com/report/industry/chemicals_petrochemicals/adm_in_ingredients_world.html
2,5-Dichloronicotinic acid | 59782-85-32,5-Dichloronicotinic acid | 59782-85-3
Visit ChemicalBook To find more 2,5-Dichloronicotinic acid(59782-85-3) information like chemical properties,Structure,melting point,boiling point,density,molecular formula,molecular weight, physical properties,toxicity information,customs codes. You can also browse global suppliers,vendor,prices,Price,manufacturers of 2,5-Dichloronicotinic acid(59782-85-3). At last,2,5-Dichloronicotinic acid(59782-85-3) safety, risk, hazard and MSDS, CAS,cas number,Use,cas no may also be you need.
http://www.chemicalbook.com/ChemicalProductProperty_EN_CB3480612.htm
Genome-Wide Association Study on Plasma Levels of Midregional-Proadrenomedullin and C-Terminal-Pro-Endothelin-1 | HypertensionGenome-Wide Association Study on Plasma Levels of Midregional-Proadrenomedullin and C-Terminal-Pro-Endothelin-1 | Hypertension
Endothelin-1 (ET-1) and adrenomedullin (ADM) are circulating vasoactive peptides involved in vascular homeostasis and endothelial function. Elevated levels of plasma ET-1 and ADM, and their biologically stable surrogates, C-terminal-pro-endothelin-1 (CT-pro-ET-1) and midregional proadrenomedullin (MR-pro-ADM), are predictors of cardiac death and heart failure. We studied the association of common genetic variation with MR-pro-ADM and CT-pro-ET-1 by genome-wide association analyses in 3444 participants of European ancestry. We performed follow-up genotyping of single nucleotide polymorphisms (SNPs) that showed suggestive or significant association in the discovery stage in additional 3230 participants. The minor variants in KLKB1 (rs4253238) and F12 (rs2731672), both part of the kallikrein-kinin system, were associated with higher MR-pro-ADM (P=4.46E-52 and P=5.90E-24, respectively) and higher CT-pro-ET-1 levels (P=1.23E-122 and P=1.26E-67, respectively). Epistasis analyses showed a significant ...
http://hyper.ahajournals.org/content/early/2013/02/04/HYPERTENSIONAHA.111.203117
Adrenomedullin regulated by miRNA-574-3p protects premature infants with bronchopulmonary dysplasia | Bioscience Reports |...Adrenomedullin regulated by miRNA-574-3p protects premature infants with bronchopulmonary dysplasia | Bioscience Reports |...
Bronchopulmonary dysplasia (BPD) is the most common chronic lung disease (CLD) in premature infants. This study was designed to elucidate the regulation of miRNA-547-3p on adrenomedullin (ADM) during the pathogenesis of BPD. We used Agilent Human 4x44K Gene Expression Microarrays v2 and miRCURY LNA™ microRNA Array to identify the differently expressed miRNA and its potential target genes, and certified them again by luciferase reporter gene analysis. We only retained target genes that met the following two conditions: first, coexisting in two databases, and second, expressing differences, and then identifying target genes by luciferase reporter gene analysis. Thus, we selected miRNA-574-3p and its target gene ADM for further research. We used real-time q-PCR to determine the expression of miRNA-574-3p and its target gene ADM in premature infants with BPD. We used microarray expression to analyze BPD samples and non-BPD samples and found that there were 516 differently expressed probes between ...
https://portlandpress.com/bioscirep/article/doi/10.1042/BSR20191879/224160/Adrenomedullin-regulated-by-miRNA5743p-protects
Altered mRNA expression levels of vaspin and adiponectin in peripheral blood mononuclear cells of systemic lupus erythematosus...Altered mRNA expression levels of vaspin and adiponectin in peripheral blood mononuclear cells of systemic lupus erythematosus...
p,Objectives,/p, ,p,Increasing studies have indicated the association between adipokines and multiple autoimmune diseases. This study aimed to evaluate the mRNA expression levels of vaspin, adiponectin and adrenomedullin in peripheral blood mononuclear cells (PBMCs) of patients with systemic lupus erythematosus (SLE), as well as their clinical associations. ,/p, ,p,Methods,/p, ,p,A total of 46 SLE patients and 51 normal controls were recruited. The three adipokines expression levels in PBMCs from SLE patients were measured by qRT-PCR, and their associations with major clinical and laboratory parameters of SLE patients were also analyzed. ,/p, ,p,Results,/p, ,p,Compared with normal controls, vaspin expression level in PBMCs was significantly decreased (P , 0.001), whereas adiponectin expression level was significantly higher in SLE patients (P , 0.001). There was no significant difference in adrenomedullin expression level between SLE patients and normal controls. Vaspin and adrenomedullin ...
http://epubs.surrey.ac.uk/849946/
ELISA Kit for Complement Factor H (CFH) | SEA635Mu | Mus musculus (Mouse) CLOUD-CLONE CORP.(CCC)ELISA Kit for Complement Factor H (CFH) | SEA635Mu | Mus musculus (Mouse) CLOUD-CLONE CORP.(CCC)
SEA635Mu, CF-H; FH; FHL1; ARMD4; ARMS1; CFHL3; HF1; HF2; HUS; H Factor 2; Age-Related Maculopathy Susceptibility 1; Adrenomedullin binding protein | Products for research use only!
http://cloud-clone.com/products/SEA635Mu.html
Adrenomedullin enhances invasion of human extravillous cytotrophoblast-derived cell lines by regulation of urokinase...
PubMedID: 23242529 | Adrenomedullin enhances invasion of human extravillous cytotrophoblast-derived cell lines by regulation of urokinase plasminogen activator expression and s-nitrosylation. | Biology of reproduction | 2/1/2013
https://www.docphin.com/research/article-detail/1001352/PubMedID-23242529/Adrenomedullin-enhances-invasion-of-human-extravillous-cytotrophoblast-derived-cell-lines-by-regulation-of-urokinase-plasminogen-activator-expression-and-s-nitrosylation
Renin-angiotensin CV physiologyRenin-angiotensin CV physiology
From Miller Cardiac hormones are polypeptides secreted by cardiac tissues into the circulation in the normal heart. Natriuretic peptides, aldosterone, and adrenomedullin are hormones secreted by cardiomyocytes. Angiotensin II, the effector hormone in the renin-angiotensin system, is also produced by cardiomyocytes. The renin-angiotensin system is one of the most important regulators of cardiovascular physiology. It is a key modulator of cardiac growth and function. Angiotensin II stimulates two separate receptor subtypes, AT1 and AT2, both of which are present in the heart. AT1 receptors are the predominant subtype expressed in the normal adult human heart. Stimulation of AT1 receptors induces a positive chronotropic and inotropic effect. Angiotensin II also mediates cell growth and proliferation in cardiomyocytes and fibroblasts and induces release of the growth factors aldosterone and catecholamines through stimulation of AT1 receptors. Activation of AT1 receptors is directly involved in the ...
http://www.openanesthesia.org/renin-angiotensin_cv_physiology/
Study: Cardiac biomarkers predicted CV events in CAP | Global Academy for Medical EducationStudy: Cardiac biomarkers predicted CV events in CAP | Global Academy for Medical Education
These biomarkers were also used to predict late cardiovascular events at day 30 of community-acquired pneumonia (CAP) in patients who did not have a history of cardiovascular disease, according to Rosario Menéndez, MD, from the Hospital Universitario y Politécnico La Fe and Instituto de Investigación Sanitaria La Fe in Valencia, Spain, and colleagues.. Some patients have still high levels of inflammatory and cardiac biomarkers at 30 days, when they are usually referred to primary care without receiving any specific additional recommendations, Dr. Menéndez and colleagues wrote in CHEST. Our results suggest that a change in usual practice is needed to reduce current and further cardiovascular CAP complications.. Dr. Menéndez and colleagues prospectively followed 730 patients for 1 year who were hospitalized for CAP, measuring the cardiac biomarkers proadrenomedullin (proADM), pro b-type natriuretic peptide (proBNP), proendothelin-1, and troponin T, and the inflammatory biomarkers ...
https://www.globalacademycme.com/click-for-credit/study-cardiac-biomarkers-predicted-cv-events-cap
Epitope specificity of anti-Adrenomedullin antibodies determines efficacy of mortality reduction in a cecal ligation and...Epitope specificity of anti-Adrenomedullin antibodies determines efficacy of mortality reduction in a cecal ligation and...
Adrenomedullin (ADM), a circulating vasodilatory peptide, plays an important role in the development of sepsis-associated hemodynamic and microcirculatory disorders. While administration of exogenous ADM had beneficial effects in several septic animal models, elevated ADM concentrations are associated with a bad outcome. This prompted us to test the effect of various anti-ADM antibodies in a cecal ligation and puncture (CLP) mouse model. To gain new potential compounds for the treatment or prevention of septic shock we followed an alternative strategy to influence the ADM system: High-affinity anti-ADM antibodies with different epitope specificities were developed and their antagonist activity in vitro and their ability to reduce mortality in a CLP mouse model were assessed. An anti-ADM antibody directed against the N-terminus substantially increased the survival of mice in a CLP model (HR = 0.077 (CI = 0.0189 to 0.315), p = 0.0004), whereas other antibodies with similar affinities but different epitope
https://icm-experimental.springeropen.com/articles/10.1186/2197-425X-1-3/figures/1
THE MOLECULAR PHARMACOLOGY OF RECEPTORS FOR CGRP, AMYLIN AND ADRENOMEDULLIN | Biochemical Society TransactionsTHE MOLECULAR PHARMACOLOGY OF RECEPTORS FOR CGRP, AMYLIN AND ADRENOMEDULLIN | Biochemical Society Transactions
Thank you for your interest in spreading the word about Biochemical Society Transactions.. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.. ...
http://www.biochemsoctrans.org/content/25/3/428S.6
Adrenomedullin: a marker of impaired hemodynamics, organ dysfunction, and poor prognosis in cardiogenic shockAdrenomedullin: a marker of impaired hemodynamics, organ dysfunction, and poor prognosis in cardiogenic shock
Both bio-ADM and lactate were higher in 90-day non-survivors compared to survivors at all time points (P , 0.05 for all). Lactate showed good prognostic value during the initial 24 h (AUC 0.78 at admission and 0.76 at 24 h). Subsequently, lactate returned normal (≤2 mmol/L) in most patients regardless of later outcome with lower prognostic value. By contrast, bio-ADM showed increasing prognostic value from 48 h and beyond (AUC 0.71 at 48 h and 0.80 at 5-10 days). Serial measurements of either bio-ADM or lactate were independent of and provided added value to CardShock risk score (P , 0.001 for both). Ninety-day mortality was more than double higher in patients with high levels of bio-ADM (,55.7 pg/mL) at 48 h compared to those with low bio-ADM levels (49.1 vs. 22.6%, P = 0.001). High levels of bio-ADM were associated with impaired cardiac index, mean arterial pressure, central venous pressure, and systolic pulmonary artery pressure during the study period. Furthermore, high levels of bio-ADM ...
https://erepo.uef.fi/handle/123456789/4315
Adrecizumab-LPS Study - Full Text View - ClinicalTrials.govAdrecizumab-LPS Study - Full Text View - ClinicalTrials.gov
Adrenomedullin (ADM) is a natural occurring 52 amino acid peptide which is mainly expressed in endothelial and smooth muscle cells. ADM plasma levels are increased in patients with sepsis and related with severity of disease. ADM is a key regulator of vasotonus and of endothelial integrity in sepsis. Adrecizumab is an antibody against the N-terminus of ADM which only partially inhibits the bioactivity of ADM. Several septic animal studies have shown that administration of Adrecizumab leads to stabilization of hemodynamics in mice and pigs, improved renal function, reduced catecholamine demand, improved fluid balance and improved survival. The administration of Adrecizumab to rodents, non-human primates and recently humans, has been tolerated very well.. The experimental human endotoxemia model, in which healthy male volunteers receive a low dose of lipopolysaccharide (LPS) derived from Escherichia coli, is widely used to study the effects of systemic inflammation in humans in vivo and is ...
https://www.clinicaltrials.gov/ct2/show/NCT03083171
Male-female differences in fertility and blood pressure in ACE-deficient miceMale-female differences in fertility and blood pressure in ACE-deficient mice
Angiotensin-converting enzyme (ACE) is a dipeptidyl carboxy-peptidase that generates the vasoconstricting peptide angiotensin II and inactivates the vasodilating peptide bradykinin. The gene encoding ACE is composed of two homologous regions and codes for both a somatic and testis isoenzyme. Experim …
https://pubmed.ncbi.nlm.nih.gov/7753170/?dopt=Abstract
Plus itPlus it
We read the insightful article by Cherney and Sochett (1) with interest. The authors carefully compared changes in kidney hemodynamic function and arterial stiffness in young subjects with type 1 diabetes with and without renal hyperfiltration. During the transition from adolescence to early adulthood, hyperfiltration was not sustained, whereas glomerular filtration rate remained stable in normofiltering subjects. In contrast, arterial stiffness decreased in all patients regardless of filtration status, suggesting that age-related increases in arterial stiffness occur at older ages. It was also mentioned that a variety of factors influence hyperfiltration including the renin-angiotensin system (measured in the study by Cherney and Sochett), cyclo-oxygenase 2, reduced bioavailability of nitric oxide, etc. However, it was unclear why only a subgroup of type 1 diabetes attained hyperfiltration.. We would like to highlight another hormonal system, adrenomedullin (ADM), a powerful endothelial-derived ...
http://care.diabetesjournals.org/content/34/12/e182
Plus itPlus it
Diabetes may be a consequence of pancreatic cancer, preceding cancer diagnosis. The underlying mechanism is the release exosomes delivering adrenomedullin to β-cells, inducing endoplasmic reticulum stress and perturbations in the unfolded protein response, leading to β-cell dysfunction and death. This knowledge could lead to improved diagnostic strategies for pancreatic cancer. ...
http://clincancerres.aacrjournals.org/content/early/2015/01/31/1078-0432.CCR-14-2990
Solaris sadmind adm build path - Remote Buffer Overflow (Metasploit)Solaris sadmind adm build path - Remote Buffer Overflow (Metasploit)
Solaris sadmind adm_build_path - Remote Buffer Overflow (Metasploit). CVE-2008-4556. Remote exploit for Solaris platform. Tags: Metasploit Framework (MSF)
https://www.exploit-db.com/exploits/9920/
AdrenomedullinAdrenomedullin
... (ADM or AM) is a vasodilator peptide hormone of uncertain significance in human health and disease. It was ... Adrenomedullin may function as a hormone in the circulation control because it is found in blood in a considerable ... The adrenomedullin knockout is an embryonic lethal phenotype and dies mid gestation from a condition known as hydrops fetalis. ... Adrenomedullin at the US National Library of Medicine Medical Subject Headings (MeSH) Human ADM genome location and ADM gene ...
https://en.wikipedia.org/wiki/Adrenomedullin
ADM2ADM2
"Entrez Gene: ADM2 adrenomedullin 2". Human ADM2 genome location and ADM2 gene details page in the UCSC Genome Browser. Kawai M ... Takei Y, Inoue K, Ogoshi M, Kawahara T, Bannai H, Miyano S (Jan 2004). "Identification of novel adrenomedullin in mammals: a ... 2006). "Immunocytochemical localization of adrenomedullin 2/intermedin-like immunoreactivity in human hypothalamus, heart and ...
https://en.wikipedia.org/wiki/ADM2
Heme oxygenaseHeme oxygenase
Endogenous inducers include i) lipids such as lipoxin and epoxyeicosatrienoic acid; and ii) peptides such as adrenomedullin and ...
https://en.wikipedia.org/wiki/Heme_oxygenase
Jillian CornishJillian Cornish
"Treatment of bone disorders with adrenomedullin or adrenomedullin agonists." U.S. Patent 6,440,421, issued 27 August 2002. Reid ...
https://en.wikipedia.org/wiki/Jillian_Cornish
RAMP2RAMP2
In the presence of this (RAMP2) protein, CRLR functions as an adrenomedullin receptor. The RAMP2 protein is involved in core ... Fritz-Six KL, Dunworth WP, Li M, Caron KM (January 2008). "Adrenomedullin signaling is necessary for murine lymphatic vascular ... Kuwasako K, Kitamura K, Nagoshi Y, Eto T (2003). "Novel calcitonin-(8-32)-sensitive adrenomedullin receptors derived from co- ... 2008). "Lack of linkage and association of adrenomedullin and its receptor genes in French Caucasian rheumatoid arthritis trio ...
https://en.wikipedia.org/wiki/RAMP2
Calcitonin gene-related peptideCalcitonin gene-related peptide
... adrenomedullin, adrenomedullin 2 (intermedin) and calcitonin‑receptor‑stimulating peptide. Calcitonin is mainly produced by ... The CGRP family includes calcitonin (CT), adrenomedullin (AM), and amylin (AMY). CGRP is produced in both peripheral and ... The mammalian calcitonin gene-related peptides, adrenomedullin, amylin, and calcitonin receptors". Pharmacological Reviews. 54 ... which is necessary for CGRP and adrenomedullin (AM receptors). For function CGRP, CALCRL must coincide with RAMP1 where the ...
https://en.wikipedia.org/wiki/Calcitonin_gene-related_peptide
Sodium nitroprussideSodium nitroprusside
2002). "Possible role of nitric oxide and adrenomedullin in bipolar affective disorder". Neuropsychobiology. 45 (2): 57-61. doi ...
https://en.wikipedia.org/wiki/Sodium_nitroprusside
BCL2L10BCL2L10
Li Z, Takeuchi S, Ohara N, Maruo T (2003). "Paradoxically abundant expression of Bcl-2 and adrenomedullin in invasive cervical ...
https://en.wikipedia.org/wiki/BCL2L10
GPR182GPR182
1998). "Expression of the rat adrenomedullin receptor or a putative human adrenomedullin receptor does not correlate with ... 2004). "[Study of the expression and role of adrenomedullin and adrenomedullin receptor in patients with chronic obstructive ... of the rat adrenomedullin receptor or a putative human adrenomedullin receptor does not correlate with adrenomedullin binding ... 1997). "Expression of adrenomedullin and its receptor in normal and malignant human skin: a potential pluripotent role in the ...
https://en.wikipedia.org/wiki/GPR182
RCP9RCP9
2000). "CGRP-RCP, a novel protein required for signal transduction at calcitonin gene-related peptide and adrenomedullin ... in adrenomedullin receptor signal transduction". Peptides. 22 (11): 1773-81. doi:10.1016/S0196-9781(01)00517-4. PMID 11754963. ...
https://en.wikipedia.org/wiki/RCP9
Chromogranin AChromogranin A
2005). "High plasma levels of human chromogranin A and adrenomedullin in patients with pheochromocytoma". Tumori. 91 (1): 53-8 ...
https://en.wikipedia.org/wiki/Chromogranin_A
RAMP3RAMP3
In the presence of this (RAMP3) protein, CRLR functions as an adrenomedullin receptor with low affinity for CGRP. GRCh38: ... Kuwasako K, Kitamura K, Nagoshi Y, Eto T (2003). "Novel calcitonin-(8-32)-sensitive adrenomedullin receptors derived from co- ... 2005). "Receptor activity-modifying protein (RAMP) isoform-specific regulation of adrenomedullin receptor trafficking by NHERF- ... receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In humans and other ...
https://en.wikipedia.org/wiki/RAMP3
RAMP1RAMP1
Kuwasako K, Kitamura K, Nagoshi Y, Eto T (2003). "Novel calcitonin-(8-32)-sensitive adrenomedullin receptors derived from co- ... 2004). "Tumor necrosis factor-alpha downregulates adrenomedullin receptors in human coronary artery smooth muscle cells". ... receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In combination with the ... adrenomedullin, and amylin receptor function". Mol. Pharmacol. 74 (4): 1059-71. doi:10.1124/mol.108.047142. PMID 18593822. ...
https://en.wikipedia.org/wiki/RAMP1
Stress in medical studentsStress in medical students
Stress can cause high levels of the following hormones: norepinephrine, leptin, NPY, nitrite, ACTH and adrenomedullin. Elevated ...
https://en.wikipedia.org/wiki/Stress_in_medical_students
EclampsiaEclampsia
The placenta normally produces the potent vasodilator adrenomedullin but it is reduced in pre-eclampsia and eclampsia. Other ... "Adrenomedullin is decreased in preeclampsia because of failed response to epidermal growth factor and impaired syncytialization ...
https://en.wikipedia.org/wiki/Eclampsia
CALCRLCALCRL
Born W, Muff R, Fischer JA (2002). "Functional interaction of G protein-coupled receptors of the adrenomedullin peptide family ... 1999). "The RAMP2/CRLR complex is a functional adrenomedullin receptor in human endothelial and vascular smooth muscle cells". ... 2000). "CGRP-RCP, a novel protein required for signal transduction at calcitonin gene-related peptide and adrenomedullin ... Hill H, Pioszak A (2013). "Bacterial expression and purification of a heterodimeric adrenomedullin receptor extracellular ...
https://en.wikipedia.org/wiki/CALCRL
Receptor activity-modifying proteinReceptor activity-modifying protein
The likelihood is that the phenotype of RAMP2 KO mice is more connected with the abolition of most adrenomedullin (AM) ... "The RAMP2/CRLR complex is a functional adrenomedullin receptor in human endothelial and vascular smooth muscle cells". FEBS ... to AM KO mice and mice lacking the Calcitonin-like receptor which are unable to form either AM1 or AM-2 adrenomedullin ...
https://en.wikipedia.org/wiki/Receptor_activity-modifying_protein
Factor HFactor H
... and physiological actions of factor H as an adrenomedullin binding protein present in human plasma". Microscopy Research and ...
https://en.wikipedia.org/wiki/Factor_H
Natriuretic peptide precursor CNatriuretic peptide precursor C
Evans JJ, Youssef AH, Yandle TG, Lewis LK, Nicholls MG (October 2002). "Effects of endothelin-1 on release of adrenomedullin ...
https://en.wikipedia.org/wiki/Natriuretic_peptide_precursor_C
A. Mark RichardsA. Mark Richards
"Mid-regional pro-adrenomedullin outperforms N-terminal pro-B-type natriuretic peptide for the diagnosis of acute heart failure ... Plasma N-terminal pro-brain natriuretic peptide and adrenomedullin: new neurohormonal predictors of left ventricular function ...
https://en.wikipedia.org/wiki/A._Mark_Richards
Debbie Lucy HayDebbie Lucy Hay
"CL/RAMP2 and CL/RAMP3 produce pharmacologically distinct adrenomedullin receptors: a comparison of effects of adrenomedullin22- ...
https://en.wikipedia.org/wiki/Debbie_Lucy_Hay
Atrial natriuretic peptideAtrial natriuretic peptide
... and adrenomedullin. Neutral endopeptidase (NEP) also known as neprilysin is the enzyme that metabolizes natriuretic peptides. ...
https://en.wikipedia.org/wiki/Atrial_natriuretic_peptide
CalcitoninCalcitonin
... and the precursor of adrenomedullin. Secretion of calcitonin is stimulated by: an increase in serum [Ca2+] gastrin and ...
https://en.wikipedia.org/wiki/Calcitonin
Signaling peptide receptorSignaling peptide receptor
PHI PHM PHV Endogenous Adrenomedullin Apelin Asprosin Bombesin Calcitonin Carnosine CART CLIP DSIP Enteroglucagon Formyl ...
https://en.wikipedia.org/wiki/Signaling_peptide_receptor
Neuroendocrine differentiationNeuroendocrine differentiation
... and adrenomedullin. The physiology of their secretion and its regulation is incompletely understood. Regulatory cues might come ...
https://en.wikipedia.org/wiki/Neuroendocrine_differentiation
ADMADM
... the national authority managing Morocco's expressways Abductor digiti minimi muscle of hand Adrenomedullin, a vasodilator ...
https://en.wikipedia.org/wiki/ADM
Amylin familyAmylin family
... and adrenomedullin. Calcitonin is a 32 amino acid polypeptide hormone that causes a rapid but short-lived drop in the level of ...
https://en.wikipedia.org/wiki/Amylin_family
Rhodopsin-like receptorsRhodopsin-like receptors
Adrenomedullin receptor (GPR182) Duffy blood group, chemokine receptor (DARC, DUFF) G Protein-coupled Receptor 30 (GPER, CML2, ...
https://en.wikipedia.org/wiki/Rhodopsin-like_receptors
Tumor-associated macrophageTumor-associated macrophage
... adrenomedullin, and semaphorin 4D. Moreover, cytokines produced by TAMs induce tumor cells to produce pro-angiogenic factors, ...
https://en.wikipedia.org/wiki/Tumor-associated_macrophage
Arthur ChristopoulosArthur Christopoulos
Structure and dynamics of the adrenomedullin (AM) receptors, AM1 and AM2, reveals key mechanisms in the control of receptor ...
https://en.wikipedia.org/wiki/Arthur_Christopoulos
Adrenomedullin in the treatment of pulmonary hypertension | HeartAdrenomedullin in the treatment of pulmonary hypertension | Heart
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Centers RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.. ...
https://heart.bmj.com/content/84/6/575.share
WikiGenes - ADM - adrenomedullinWikiGenes - ADM - adrenomedullin
Adrenomedullin and calcitonin gene-related peptide interact with the same receptor in cultured human neuroblastoma SK-N-MC ... Adrenomedullin is expressed in pancreatic cancer and stimulates cell proliferation and invasion in an autocrine manner via the ... Interaction of human adrenomedullin 13-52 with calcitonin gene-related peptide receptors in the microvasculature of the rat and ... The seven amino acids of human RAMP2 (86) and RAMP3 (59) are critical for agonist binding to human adrenomedullin receptors. ...
https://www.wikigenes.org/e/gene/e/133.html
Mouse adrenomedullin, ADM ELISA Kit | CSB-E10061m | CusabioMouse adrenomedullin, ADM ELISA Kit | CSB-E10061m | Cusabio
Mouse adrenomedullin, ADM ELISA Kit from Cusabio. Cat#: CSB-E10061m. US, UK & Europe Distribution. Online Order or Request ... Mouse adrenomedullin, ADM ELISA Kit , CSB-E10061m Cusabio Elisa Mouse adrenomedullin, ADM ELISA Kit , CSB-E10061m. (No reviews ... Dog adrenomedullin, ADM ELISA Kit , CSB-E09836c , CusabioDog adrenomedullin, ADM ELISA Kit is Available at Gentaur Genprice ... Dog adrenomedullin, ADM ELISA Kit , CSB-E09836c , CusabioDog adrenomedullin, ADM ELISA Kit is Available at Gentaur Genprice ...
https://joplink.net/mouse-adrenomedullin-adm-elisa-kit-csb-e10061m/
Preventive Effect of TU-100 on a Type-2 Model of Colitis in Mice: Possible Involvement of Enhancing Adrenomedullin in...Preventive Effect of TU-100 on a Type-2 Model of Colitis in Mice: Possible Involvement of Enhancing Adrenomedullin in...
... induced type-1 model colitis exhibiting histopathological features of CD through adrenomedullin (ADM) enhancement. Our current ... Adrenomedullin (ADM) in the culture fluid was determined by ADM-specific EIA. (a), 3 (b). *. versus control by Dunnett test. ... Adrenomedullin-enhancing activity of TU-100 in intestinal epithelial cells. Intestinal epithelial cell lines IEC-6 (a) and IEC- ... V. A. Cameron and A. M. Fleming, "Novel sites of adrenomedullin gene expression in mouse and rat tissues," Endocrinology, vol. ...
https://www.hindawi.com/journals/grp/2013/384057/
Therapeutic effect of urocortin and adrenomedullin in a murine model of Crohns disease | GutTherapeutic effect of urocortin and adrenomedullin in a murine model of Crohn's disease | Gut
Urocortin (UCN) and adrenomedullin (AM) induce the appearance of CD4+CD25+Foxp3+ T cells in 2,4,6-trinitrobenzene sulfonic acid ... Kubo A, Minamino N, Isumi Y, et al. Production of adrenomedullin in macrophage cell line and peritoneal macrophage. J Biol Chem ... Urocortin (UCN) and adrenomedullin (AM) suppress Th1 cytokine response and stimulate interleukin (IL)-10 production in 2,4,6- ... Urocortin (UCN) and adrenomedullin (AM) decrease mucosal and systemic inflammatory responses in mice with 2,4,6-trinitrobenzene ...
https://gut.bmj.com/content/55/6/824
Adrenomedullin in synovial fluids from patients with rheumatoid arthritis inhibits interleukin 6 production from synoviocytes |...Adrenomedullin in synovial fluids from patients with rheumatoid arthritis inhibits interleukin 6 production from synoviocytes |...
Adrenomedullin in synovial fluids from patients with rheumatoid arthritis inhibits interleukin 6 production from synoviocytes ... Adrenomedullin in synovial fluids from patients with rheumatoid arthritis inhibits interleukin 6 production from synoviocytes ... Adrenomedullin in synovial fluids from patients with rheumatoid arthritis inhibits interleukin 6 production from synoviocytes ...
https://ard.bmj.com/content/62/1/82.share
Effects of adrenomedullin on acute ischaemia-induced collateral development and mobilization of bone-marrow-derived cells |...Effects of adrenomedullin on acute ischaemia-induced collateral development and mobilization of bone-marrow-derived cells |...
In the present study, we investigated the effects of adrenomedullin on collate ... Adrenomedullin exerts not only vasodilatory effects, but also angiogenic effects. ... Effects of adrenomedullin on acute ischaemia-induced collateral development and mobilization of bone-marrow-derived cells. Clin ... Adrenomedullin for steroid-resistant ulcerative colitis: a randomized, double-blind, placebo-controlled phase-2a clinical trial ...
https://portlandpress.com/clinsci/crossref-citedby/68135
Elevated plasma adrenomedullin and vascular manifestations in patients with systemic sclerosis. | The Journal of RheumatologyElevated plasma adrenomedullin and vascular manifestations in patients with systemic sclerosis. | The Journal of Rheumatology
Elevated plasma adrenomedullin and vascular manifestations in patients with systemic sclerosis.. Mo Yin Mok, Bernard Man Yung ... Elevated plasma adrenomedullin and vascular manifestations in patients with systemic sclerosis.. Mo Yin Mok, Bernard Man Yung ... Elevated plasma adrenomedullin and vascular manifestations in patients with systemic sclerosis.. Mo Yin Mok, Bernard Man Yung ... Elevated plasma adrenomedullin and vascular manifestations in patients with systemic sclerosis. Message Subject (Your Name) has ...
https://www.jrheum.org/content/34/11/2224
Adrenomedullin suppresses mitogenesis in rat mesangial cells via cAMP pathway<...
title = "Adrenomedullin suppresses mitogenesis in rat mesangial cells via cAMP pathway",. abstract = "Adrenomedullin (ADM) is a ... Adrenomedullin suppresses mitogenesis in rat mesangial cells via cAMP pathway. Eduardo N. Chini, Eunhee Choi, Joseph P. Grande ... Adrenomedullin suppresses mitogenesis in rat mesangial cells via cAMP pathway. / Chini, Eduardo N.; Choi, Eunhee; Grande, ... Chini, E. N., Choi, E., Grande, J. P., Burnett, J. C., & Dousa, T. P. (1995). Adrenomedullin suppresses mitogenesis in rat ...
https://mayoclinic.pure.elsevier.com/en/publications/adrenomedullin-suppresses-mitogenesis-in-rat-mesangial-cells-via-
RePub, Erasmus University Repository: Adrenomedullin and arterial stiffness integrative approach combining monocyte adm...RePub, Erasmus University Repository: Adrenomedullin and arterial stiffness integrative approach combining monocyte adm...
Adrenomedullin, Gene expression, Genome wide association scan, Vascular stiffness Persistent URL doi.org/10.1161/CIRCGENETICS. ... Adrenomedullin and arterial stiffness integrative approach combining monocyte adm expression, plasma MR-Pro-ADM, and genome- ... Background: Adrenomedullin (ADM) is a circulating vasoactive peptide involved in vascular homeostasis and endothelial function ... Beygui, F, Wild, P.S, Zeller, T, Germain, M, Castagne, R, Lackner, K.J, … Tiret, L. (2014). Adrenomedullin and arterial ...
https://repub.eur.nl/pub/85156
Endothelin 1, its endothelin type a receptor, connective tissue growth factor, platelet-derived growth factor, and...Endothelin 1, its endothelin type a receptor, connective tissue growth factor, platelet-derived growth factor, and...
... and adrenomedullin expression in lungs of pulmonary hypertensive and nonhypertensive chickens ... Interaction of adrenomedullin and platelet-derived growth factor on rat mesangial cell production of endothelin. Hypertension ... Adrenomedullin mRNA levels in the lungs of PHB were significantly higher than in NPHB (P < 0.01). It has been demonstrated for ... and adrenomedullin expression in lungs of pulmonary hypertensive and nonhypertensive chickens. Gomez, A.P.; Moreno, M.J.; ...
https://eurekamag.com/research/013/242/013242593.php
Adrenomedullin as a potential biomarker involved in patients with hereditary hemorrhagic telangiectasia | European Federation...
Adrenomedullin as a potential biomarker involved in patients with hereditary hemorrhagic telangiectasia. ...
https://efim.org/education/ejim/june-2021/adrenomedullin-potential-biomarker-involved-patients-hereditary-hemorrhagic
TRPV2 Mediates Adrenomedullin Stimulation of Prostate and Urothelial Cancer Cell Adhesion, Migration and Invasion - Aix...
Adrenomedullin (AM) is a 52-amino acid peptide initially isolated from human pheochromocytoma. AM is expressed in a variety of ... TRPV2 Mediates Adrenomedullin Stimulation of Prostate and Urothelial Cancer Cell Adhesion, Migration and Invasion Agathe Oulidi ... Abstract : Adrenomedullin (AM) is a 52-amino acid peptide initially isolated from human pheochromocytoma. AM is expressed in a ... TRPV2 Mediates Adrenomedullin Stimulation of Prostate and Urothelial Cancer Cell Adhesion, Migration and Invasion. PLoS ONE, ...
https://hal-amu.archives-ouvertes.fr/hal-01708095
Adrenomedullin (Human) › PeptaNovaAdrenomedullin (Human) › PeptaNova
Adrenomedullin (Human) 4278-s 0.1 mg , 205.00 EURSynthetic Product (Disulfide bond between Cys16-Cys21)Tyr - Arg - Gln - Ser - ... In addition Adrenomedullin is suspected to play a role in the early stages of sepsis. Circulating Adrenomedullin can be easily ... Adrenomedullin was first described in 1993 as an ubiquitous peptide expressed by numbers of different cell types. It has been ... The biological activity of human Adrenomedullin offered by PeptaNova is examined by the Division of Pharmacology of Peptide ...
https://peptanova.de/product/adrenomedullin-human/
miR-1297 sensitizes glioma cells to temozolomide (TMZ) treatment through targeting adrenomedullin (ADM) | Journal of...miR-1297 sensitizes glioma cells to temozolomide (TMZ) treatment through targeting adrenomedullin (ADM) | Journal of...
Adrenomedullin (ADM) has been reported to induce glioblastoma cell growth. Cell viability was measured using the CCK-8 assay. ... Adrenomedullin (ADM) has been reported to induce glioblastoma cell growth.. Methods. Cell viability was measured using the CCK- ... miR-1297 sensitizes glioma cells to temozolomide (TMZ) treatment through targeting adrenomedullin (ADM). *Zongze He1,2 na1, ... Neutralization of adrenomedullin inhibits the growth of human glioblastoma cell lines in vitro and suppresses tumor xenograft ...
https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-022-03647-6
Adrenomedullin (24-50) (Mouse)
Structure-function analysis of amino acid 74 of human RAMP1 and RAMP3 and its role in peptide interactions with adrenomedullin...Structure-function analysis of amino acid 74 of human RAMP1 and RAMP3 and its role in peptide interactions with adrenomedullin...
Structure-function analysis of amino acid 74 of human RAMP1 and RAMP3 and its role in peptide interactions with adrenomedullin ... Structure-function analysis of amino acid 74 of human RAMP1 and RAMP3 and its role in peptide interactions with adrenomedullin ... Structure-function analysis of amino acid 74 of human RAMP1 and RAMP3 and its role in peptide interactions with adrenomedullin ... Structure-function analysis of amino acid 74 of human RAMP1 and RAMP3 and its role in peptide interactions with adrenomedullin ...
https://research.aston.ac.uk/en/publications/structure-function-analysis-of-amino-acid-74-of-human-ramp1-and-r
Cattle ADM(Adrenomedullin) ELISA Kit - Orbital Biosciences onlineCattle ADM(Adrenomedullin) ELISA Kit - Orbital Biosciences online
Description: A sandwich ELISA kit for detection of Adrenomedullin from Rat in samples from blood, serum, plasma, cell culture ... Description: A sandwich quantitative ELISA assay kit for detection of Rat Adrenomedullin (ADM) in samples from serum, plasma or ... Description: A sandwich quantitative ELISA assay kit for detection of Rat Adrenomedullin (ADM) in samples from serum, plasma or ... Description: A sandwich quantitative ELISA assay kit for detection of Mouse Adrenomedullin (ADM) in samples from serum, plasma ...
https://orbitalbiosciences.com/cattle-admadrenomedullin-elisa-kit/
Human Adrenomedullin (ADM) ELISA Kit, Cat#EKU11666 - BiomatikHuman Adrenomedullin (ADM) ELISA Kit, Cat#EKU11666 - Biomatik
Human Adrenomedullin (ADM) ELISA Kit, Cat#EKU11666. Write a Review Write a Review. × ... Human Adrenomedullin (ADM) ELISA Kit, Cat#EKU11666. Rating Required Select Rating. 1 star (worst). 2 stars. 3 stars (average). ... This assay has high sensitivity and excellent specificity for detection of Adrenomedullin (ADM). No significant cross- ... reactivity or interference between Adrenomedullin (ADM) and analogues was observed.. Test principle. The test principle applied ...
https://www.biomatik.com/elisa-kits/human-adrenomedullin-adm-elisa-kit-cat-eku11666/
Human ADM2(Adrenomedullin 2) ELISA Kit - ELISA KitsHuman ADM2(Adrenomedullin 2) ELISA Kit - ELISA Kits
Human ADM2(Adrenomedullin 2) ELISA Kit. Human ADM2(Adrenomedullin 2) ELISA Kit. Contact us: [email protected] ... Description: A competitive Inhibition ELISA kit for detection of Adrenomedullin 2 from Human in samples from blood, serum, ... Description: A sandwich quantitative ELISA assay kit for detection of Human Adrenomedullin (ADM) in samples from serum, plasma ... Description: A sandwich quantitative ELISA assay kit for detection of Human Adrenomedullin (ADM) in samples from serum, plasma ...
https://myelisakit.com/human-adm2adrenomedullin-2-elisa-kit/
Kounis SyndromeKounis Syndrome
Adrenomedullin. Angiogenin/angiopoietin. Endothelial growth factor. Fibroblast growth factor α and basic. ...
https://www.medscape.com/viewarticle/732843
Penurunan Kadar Pro-adrenomedullin Mencit Balb/C Model Sepsis dengan Kortikosteroid Dosis Rendah | Prasetyo | Majalah...Penurunan Kadar Pro-adrenomedullin Mencit Balb/C Model Sepsis dengan Kortikosteroid Dosis Rendah | Prasetyo | Majalah...
Penurunan Kadar Pro-adrenomedullin Mencit Balb/C Model Sepsis dengan Kortikosteroid Dosis Rendah ... Kata kunci: Kortikosteroid dosis rendah, pro-adrenomedullin, sepsis. Pro-adrenomedullin Level Reduction in Balb/C Sepsis Model ... Pro-adrenomedullin (pro-ADM) is a biomarker of sepsis severity. This study aimed to analyze the effects of the use of low-dose ... Pro-adrenomedullin (pro-ADM) merupakan biomarker keparahan sepsis. Penelitian ini bertujuan untuk menganalisis efek penggunaan ...
http://journal.fk.unpad.ac.id/index.php/mkb/article/view/276
Effect of intermedin/adrenomedullin(2) on the pulmonary vascular bed in hypoxia-induced pulmonary hypertensive rats | AVESİSEffect of intermedin/adrenomedullin(2) on the pulmonary vascular bed in hypoxia-induced pulmonary hypertensive rats | AVESİS
Effect of intermedin/adrenomedullin(2) on the pulmonary vascular bed in hypoxia-induced pulmonary hypertensive rats ... Keywords: Intermedin/adrenomedullin(2), Hypoxia-induced pulmonary hypertension, Isolated rat lung, Pulmonary artery, GENE- ... RELATED PEPTIDE, ARTERIAL-HYPERTENSION, NITRIC-OXIDE, FAMILY PEPTIDE, ADRENOMEDULLIN, VASODILATION, INTERMEDIN, MAMMALS, ...
https://avesis.hacettepe.edu.tr/yayin/b656118b-f5b1-4a2d-8703-a56a7cff73d2/effect-of-intermedin-adrenomedullin2-on-the-pulmonary-vascular-bed-in-hypoxia-induced-pulmonary-hypertensive-rats
Neuroscience Elisa | Gentaur Elisa Kits | US - UK & Europe SupplyNeuroscience Elisa | Gentaur Elisa Kits | US - UK & Europe Supply
Rat ADM (Adrenomedullin) ELISA Kit , G-EC-05861 MSRP: Was: Now: $248.00 - $3,702.00 ...
https://caslab.com/neuroscience-elisa/
PTEN function: how normal cells control it and tumour cells lose it. - National Centers for Biomedical ComputingPTEN function: how normal cells control it and tumour cells lose it. - National Centers for Biomedical Computing
In Part II of this paper we give a complete evaluate each of tissues and cell traces secreting adrenomedullin and of the ... Because the discovery of adrenomedullin in 1993 a number of hundred papers have been printed relating to the regulation of its ... It has been proven to be an nearly ubiquitous peptide, with the variety of tissues and cell sorts synthesizing adrenomedullin ... In Part IV the assorted actions of adrenomedullin are mentioned: its actions on mobile progress, the cardiovascular system, the ...
https://www.ncbcs.org/pten-function-how-normal-cells-control-it-and-tumour-cells-lose-it/
Frontiers | Soluble Mediators Regulating Immunity in Early LifeFrontiers | Soluble Mediators Regulating Immunity in Early Life
Zudaire E, Portal-Nunez S, Cuttitta F. The central role of adrenomedullin in host defense. J Leukoc Biol (2006) 80(2):237-44. ... Allaker RP, Zihni C, Kapas S. An investigation into the antimicrobial effects of adrenomedullin on members of the skin, oral, ... Adrenomedullin (AM), a cleavage product of preproadrenomedullin, is a circulatory neuropeptide hormone. AM stimulates ... Gonzalez-Rey E, Chorny A, Varela N, Robledo G, Delgado M. Urocortin and adrenomedullin prevent lethal endotoxemia by down- ...
https://www.frontiersin.org/articles/10.3389/fimmu.2014.00457/full
Adrenomedullin enhances baroreceptor reflex response via cAMP/PKA signaling in nucleus tractus solitarii of rats<...
Ho, LK, Chen, K, Ho, IC, Shen, YC, Yen, DHT, Li, FCH, Lin, YC, Kuo, WK, Lou, YJ & Yen, JC 2008, Adrenomedullin enhances ... Adrenomedullin enhances baroreceptor reflex response via cAMP/PKA signaling in nucleus tractus solitarii of rats. / Ho, L. K.; ... Adrenomedullin enhances baroreceptor reflex response via cAMP/PKA signaling in nucleus tractus solitarii of rats. In: ... keywords = "Adrenomedullin, Baroreceptor reflex, Nucleus tractus solitarii, Protein kinase A, Rat",. author = "Ho, {L. K.} and ...
https://scholar.nycu.edu.tw/en/publications/adrenomedullin-enhances-baroreceptor-reflex-response-via-camppka-
Potensi terapi kombinasi Liver Growth Factor (LGF) dan Adrenomedullin (ADM) sebagai harapan baru penatalaksanaan Azoospermia...Potensi terapi kombinasi Liver Growth Factor (LGF) dan Adrenomedullin (ADM) sebagai harapan baru penatalaksanaan Azoospermia...
CL/RAMP2 and CL/RAMP3 produce pharmacologically distinct adrenomedullin receptors: a comparison of effects of adrenomedullin 22 ... Coexpression of adrenomedullin and its receptors in the reproductive system of the rat: effects on steroid secretion in rat ... Adrenomedullin regulates sperm motility and oviductal ciliary beat via cyclic adenosine 5-monophosphate/protein kinase A and ... Adrenomedullin regulates sperm motility and oviductal ciliary beat via cyclic adenosine 5-monophosphate/protein kinase A and ...
https://isainsmedis.id/index.php/ism/article/view/1363
Early predictors of perinatal brain damage: the role of neurobiomarkersEarly predictors of perinatal brain damage: the role of neurobiomarkers
... adrenomedullin), brain biomarkers (activin A, neuron specific enolase, glial fibrillary acidic protein, ubiquitin carboxyl- ... Increased gene expression of adrenomedullin and adrenomedullin-receptor complexes, receptor-activity modifying protein (RAMP) 2 ... Hypoxia-induced adrenomedullin production in the kidney. Kidney Int 1999;55:1259-67.10.1046/j.1523-1755.1999.00361.xSearch in ... Adrenomedullin: its role in perinatal adaptation. Acta Paediatr 1998;87:235-6.10.1111/j.1651-2227.1998.tb01430.xSearch in ...
https://www.degruyter.com/document/doi/10.1515/cclm-2019-0725/html
Hyponatremia in the Emergency Department: Could Biomarkers Help in Diagnosis and Treatment?Hyponatremia in the Emergency Department: Could Biomarkers Help in Diagnosis and Treatment?
Mid-regional pro-adrenomedullin (MR-proADM) andproendothelin-1 (proET-1) was also analysed. No association was found between ... Levels of mid-regional pro-atrial natriuretic peptide (MR-proANP), copeptin, mid-regional pro-adrenomedullin (MR-proADM), pro- ... Mid-regional pro-atrial natriuretic peptide (MR-proANP), copeptin, mid-regional pro-adrenomedullin (MR-proADM) and pro-endothe ...
https://www.scirp.org/journal/paperinformation.aspx?paperid=64817
PeptideSepsisPeptidesCGRPPotent vasodilatorReceptorsElisaADM21993AnaloguesVascularProteinsDetectionHumanPlasmaEffectCellPatientsLevelsGrowthMedicinePeptidesEffect of adrenomedullinPrognosticTotal adrenomedullinBiologicallyPotentReceptor activitConcentrationsMRNAPlasmaGeneEndogenousPharmacologicalMediatesNitricVascular smooth musclOrgan DamageCRLRSeveral tissuesHumanTherapeuticRegulationRoleEffectsBiomarkersHormoneAcute
Peptide13
  • TU-100 activates transient receptor potential ankyrin 1 (TRPA1) expressed on intestinal epithelial cells, followed by release of the vasodilator peptide adrenomedullin (ADM). (hindawi.com)
  • OBJECTIVE: Adrenomedullin (ADM), a vasodilating peptide that possesses antiinflammatory properties, may have a regulatory role in the vascular manifestations of scleroderma (systemic sclerosis, SSc). (jrheum.org)
  • Adrenomedullin (ADM) is a vasoactive peptide that was recently localized in renal glomeruli. (elsevier.com)
  • Background: Adrenomedullin (ADM) is a circulating vasoactive peptide involved in vascular homeostasis and endothelial function. (eur.nl)
  • Adrenomedullin (AM) is a 52-amino acid peptide initially isolated from human pheochromocytoma. (archives-ouvertes.fr)
  • The biological activity of human Adrenomedullin offered by PeptaNova is examined by the Division of Pharmacology of Peptide Institute, Inc. (peptanova.de)
  • Adrenomedullin was first described in 1993 as an ubiquitous peptide expressed by numbers of different cell types. (peptanova.de)
  • Adrenomedullin (ADM), an effective vasodilator peptide composed of 52 amino acids, is first found in human pheochromocytoma. (biomedcentral.com)
  • The receptors for calcitonin gene-related peptide (CGRP) and adrenomedullin (AM) are complexes of the calcitonin receptor-like receptor (CLR) and receptor activity-modifying proteins (RAMP). (aston.ac.uk)
  • Adrenomedullin, a multifunctional regulatory peptide. (ncbcs.org)
  • It has been proven to be an nearly ubiquitous peptide, with the variety of tissues and cell sorts synthesizing adrenomedullin far exceeding these that don't. (ncbcs.org)
  • Adrenomedullin (ADM), a 52-amino acid peptide, elicits differential cardiovascular responses when it is administered systemically or directly to the brain. (nycu.edu.tw)
  • Calcitonin gene-related peptide antagonizes the protective effect of adrenomedullin on histamine-induced bronchoconstriction. (nih.gov)
Sepsis6
  • In addition Adrenomedullin is suspected to play a role in the early stages of sepsis. (peptanova.de)
  • Pro-adrenomedullin (pro-ADM) merupakan biomarker keparahan sepsis. (unpad.ac.id)
  • Pro-adrenomedullin (pro-ADM) is a biomarker of sepsis severity. (unpad.ac.id)
  • Bioactive Adrenomedullin (bio-ADM) is a hormone regulating endothelial function and has been previously validated in over 35.000 patients with diseases where endothelial dysfunction plays a key role, such as sepsis, septic shock, cardiogenic shock, and acute heart failure. (ukaachen.de)
  • Circulating adrenomedullin estimates survival and reversibility of organ failure in sepsis: the prospective observational multinational Adrenomedullin and Outcome in Sepsis and Septic Shock-1 (AdrenOSS-1) study. (ukaachen.de)
  • Circulating Biologically Active Adrenomedullin (bio-ADM) Predicts Hemodynamic Support Requirement and Mortality During Sepsis. (ukaachen.de)
Peptides1
  • Lower levels of complement proteins and anti-microbial proteins and peptides contribute to neonatal susceptibility to infection, while elevated levels of adenosine, adiponectin, and adrenomedullin in neonatal blood may influence immune cell polarization. (frontiersin.org)
CGRP1
  • AMG 334 fully inhibited CGRP-stimulated cAMP production with an IC 50 of 2.3 nM in cell-based functional assays (human CGRP receptor) and was 5000-fold more selective for the CGRP receptor than other human calcitonin family receptors, including adrenomedullin, calcitonin, and amylin receptors. (aspetjournals.org)
Potent vasodilator1
  • Besides controlling fluid-electrolyte homeostasis, adrenomedullin is a potent vasodilator and can inhibit pituitary ACTH secretion. (bvsalud.org)
Receptors1
  • Urocortin 1 (UCN) and adrenomedullin (AM) are two recently discovered neuropeptides that, due to their distribution and binding to receptors in immune cells, have emerged as potential endogenous anti-inflammatory factors. (bmj.com)
Elisa7
  • Mouse adrenomedullin, ADM ELISA Kit is Available at Gentaur Genprice with the fastest delivery. (joplink.net)
  • CusabioDog adrenomedullin, ADM ELISA Kit is Available at Gentaur Genprice with the fastest delivery.Online Order Payment is possible or send. (joplink.net)
  • CusabioHuman adrenomedullin, ADM ELISA Kit is Available at Gentaur Genprice with the fastest delivery.Online Order Payment is possible or send. (joplink.net)
  • Description: A sandwich quantitative ELISA assay kit for detection of Bovine Adrenomedullin (ADM) in samples from serum, plasma, tissue homogenates or other biological fluids. (orbitalbiosciences.com)
  • Description: A competitive ELISA for quantitative measurement of Human adrenomedullin 2 (ADM2) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (myelisakit.com)
  • Description: Quantitativesandwich ELISA kit for measuring Human adrenomedullin 2 (ADM2) in samples from serum, plasma, cell culture supernates. (myelisakit.com)
  • Description: A competitive ELISA for quantitative measurement of Rat adrenomedullin 2 (ADM2) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (myelisakit.com)
ADM21
  • Description: This is Competitive Enzyme-linked immunosorbent assay for detection of Human Adrenomedullin 2 (ADM2) in serum, plasma, tissue homogenates and other biological fluids. (myelisakit.com)
19931
  • Because the discovery of adrenomedullin in 1993 a number of hundred papers have been printed relating to the regulation of its secretion and the multiplicity of its actions. (ncbcs.org)
Analogues2
  • Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Cattle Adrenomedullin (ADM) in samples from serum, plasma, tissue homogenates and other biological fluids with no significant corss-reactivity with analogues from other species. (orbitalbiosciences.com)
  • No significant cross-reactivity or interference between Adrenomedullin (ADM) and analogues was observed. (biomatik.com)
Vascular1
  • Elevated plasma adrenomedullin and vascular manifestations in patients with systemic sclerosis. (jrheum.org)
Proteins1
  • In the present review we offer an up-to-date overview of the most promising developments in the use of biomarkers in the perinatal period such as calcium binding proteins (S100B protein), vasoactive agents (adrenomedullin), brain biomarkers (activin A, neuron specific enolase, glial fibrillary acidic protein, ubiquitin carboxyl-terminal hydrolase-L1) and oxidative stress markers. (degruyter.com)
Detection1
  • This assay has high sensitivity and excellent specificity for detection of Adrenomedullin (ADM). (biomatik.com)
Human1
  • Comparison of peri-implant crevicular fluid levels of adrenomedullin and human beta defensins 1 and 2 from mandibular implants with different implant stability quotient levels in nonsmoker patients. (osstell.com)
Plasma2
  • Recently it was reported that an increased plasma level of Adrenomedullin could be a potential biochemical indicator for recurrent pregnancy loss. (peptanova.de)
  • Five-week yin yoga-based interventions decreased plasma adrenomedullin and increased psychological health in stressed adults: A randomized controlled trial. (bvsalud.org)
Effect1
Cell1
  • Adrenomedullin (ADM) has been reported to induce glioblastoma cell growth. (biomedcentral.com)
Patients2
  • To further support the management of critically ill patients, we have made available the assay for bioactive Adrenomedullin as a rapid near-patient test. (ukaachen.de)
  • Bio-adrenomedullin as a marker of congestion in patients with new-onset and worsening heart failure. (ukaachen.de)
Levels1
  • Adrenomedullin mRNA levels in the lungs of PHB were significantly higher than in NPHB (P (eurekamag.com)
Growth3
  • Twenty-four 1-d-old broilers were distributed in 2 groups, pulmonary hypertensive broilers (PHB) and pulmonary nonhypertensive broilers (NPHB), to estimate possible differences between them in the expression of endothelin 1 (ET-1) and its type A receptor, connective tissue growth factor, platelet-derived growth factor, and adrenomedullin expression in the lungs. (eurekamag.com)
  • It has been demonstrated for the first time that ET-1, connective tissue growth factor, and adrenomedullin are upregulated in the lungs of PHB. (eurekamag.com)
  • Referring to the problems above, non-obstructive azoospermia is an urgent health issue and requires effective and efficient management with minimal side effects, as the combination of Liver Growth Factor (LGF) and Adrenomedullin (ADM). (isainsmedis.id)
Medicine1
  • We previously reported that a traditional Japanese medicine, daikenchuto (TU-100), ameliorated a trinitrobenzenesulfonic acid- (TNBS-) induced type-1 model colitis exhibiting histopathological features of CD through adrenomedullin (ADM) enhancement. (hindawi.com)
Peptides3
  • The aim of this paper is to investigate whether urosepsis is related to irrigation pressure of ureteroscopy (URS) and evaluate the prognostic value of adrenomedullin (ADM) and atrial and brain natriuretic peptides (ANP and BNP) in URS-induced uroseptic patients. (hindawi.com)
  • Kita T, Kitamura K . Translational studies of adrenomedullin and related peptides regarding cardiovascular diseases. (neurotree.org)
  • Several of the peptides that influence feeding such as orexin, adrenomedullin and α-melanocyte-stimulating hormone (α-MSH), also have an impact on cardiovascular function. (bachem.com)
Effect of adrenomedullin1
  • 2. Coexpression of calcitonin receptor-like receptor and receptor activity-modifying protein 2 or 3 mediates the antimigratory effect of adrenomedullin. (nih.gov)
Prognostic3
  • CONCLUSION: Mid-regional pro-adrenomedullin is an independent predictor of mortality in CHF patients, which adds prognostic information to NT-proBNP. (phoenixpeptide.com)
  • 7. Expression and role of adrenomedullin in renal tumors and value of its mRNA levels as prognostic factor in clear-cell renal carcinoma. (nih.gov)
  • Prognostic value of mid-regional pro-adrenomedullin in patients with heart failure after an acute myocardial infarction. (uib.no)
Total adrenomedullin1
  • Levels of plasma total adrenomedullin are related with two acute phase inflammatory reactants (fibrinogen and sialic acid) but not with markers of endothelial dysfunction in Type 1 diabetes Adrenomedullin and vascular risk factors in Type 1 DM. (phoenixpeptide.com)
Biologically1
  • The goodness of the association was confirmed across all New York Heart Association (NYHA) functional classes and with other markers of congestion, such as bio-ADM (biologically active adrenomedullin) and the presence of peripheral oedema. (medscape.com)
Potent2
  • In addition, adrenomedullin has potent vasodilatory properties. (brahms.de)
  • Besides controlling fluid-electrolyte homeostasis, adrenomedullin is a potent vasodilator and can inhibit pituitary ACTH secretion. (nih.gov)
Receptor activit2
  • 9, 10 However, the interaction of adrenomedullin and CGRP with this receptor depends upon the coexpression of a so called receptor activity modifying protein (RAMP). (bmj.com)
  • Structural basis for extracellular interactions between calcitonin receptor-like receptor and receptor activity-modifying protein 2 for adrenomedullin-specific binding. (riken.jp)
Concentrations2
  • 5. On Rat 2 cells, expressing rat CRLR and RAMP2, BIBN4096BS was unable to antagonize adrenomedullin at concentrations up to 10 μM. (aston.ac.uk)
  • At concentrations of up to 10 μM, it has no antagonist actions at the adrenomedullin, CRLR/RAMP2 receptor, unlike CGRP 8-37 . (aston.ac.uk)
MRNA1
  • By RNA-blot analysis, human adrenomedullin mRNA was found to be highly expressed in several tissues. (ageing-map.org)
Plasma5
  • Cite this: Study of Plasma Adrenomedullin Level In Normal Pregnancy and Preclampsia - Medscape - Feb 06, 2008. (medscape.com)
  • Description: A sandwich quantitative ELISA assay kit for detection of Mouse Adrenomedullin (ADM) in samples from serum, plasma or other biological fluids. (orbitalbiosciences.com)
  • Description: This is Competitive Enzyme-linked immunosorbent assay for detection of Pig Adrenomedullin (ADM) in serum, plasma and other biological fluids. (orbitalbiosciences.com)
  • Plasma and urinary adrenomedullin levels in children with renal parenchymal scar and vesicoureteral reflux. (gazi.edu.tr)
  • Plasma and urinary adrenomedullin levels. (gazi.edu.tr)
Gene3
  • This study aimed to examine the associations between genetic variants of the adrenomedullin (ADM) gene and essential hypertension, as well as BP levels, in a Chinese Han population. (nih.gov)
  • Microsatellite DNA polymorphism of adrenomedullin gene and atherosclerotic cerebral infarction]. (cdc.gov)
  • 2010, Association of a functional polymorphism in the adrenomedullin gene (ADM) with response to paroxetine. (wustl.edu)
Endogenous2
  • Addition of 8bromo-cAMP or adrenomedullin (AM), an endogenous ligand-elevating cAMP, enhanced VEGF-induced EC differentiation. (elsevier.com)
  • The expression of the receptor in endothelial cells and in astrocytic tumour cells is consistent with the evidence that its endogenous ligand, adrenomedullin, may influence glioma growth by means of both direct mitogenic and indirect angiogenic effects. (bmj.com)
Pharmacological1
  • Adrenomedullin: a new target for the design of small moleculemodulators with promising pharmacological activities. (phoenixpeptide.com)
Mediates1
  • There is some evidence that the calcitonin receptor-like receptor (CRLR) mediates the tumorigenic actions of adrenomedullin. (bmj.com)
Nitric1
  • Vasodilator responses to endomorphin 1, PL017, and DAMGO, and the endothelium-dependent vasodilators acetylcholine and adrenomedullin were attenuated by the nitric oxide synthase inhibitor L-NAME (50 mg/kg IV) at a time when vasodilator responses to nociceptin/OFQ were not altered. (elsevier.com)
Vascular smooth muscl1
  • 19. Alterations of adrenomedullin and its receptor system components in calcified vascular smooth muscle cells. (nih.gov)
Organ Damage1
  • İseri SÖ , Ersoy Y, Gedik N, Ercan F, Alican İ. Protective role of adrenomedullin in burn-induced remote organ damage in the rat. (wjgnet.com)
CRLR1
  • To determine whether CRLR is expressed in human gliomas and the probable cellular targets of adrenomedullin. (bmj.com)
Several tissues1
  • Adrenomedullin is produced by several tissues including the heart, and portends a poor prognosis in heart diseases. (elsevier.com)
Human2
  • Adrenomedullin (ADM) was first isolated from human pheochromocytoma [ 6 ]. (hindawi.com)
  • Adrenomedullin is an important tumour survival factor in human carcinogenesis. (bmj.com)
Therapeutic1
  • In part A of the study two active doses of inhaled pegylated adrenomedullin (PEG-ADM) will be compared regarding safety and efficacy to a substance that has no therapeutic effect (placebo) in order to find an optimal and safe of the study drug. (centerwatch.com)
Regulation3
  • Regulation of uterine contractility by adrenomedullin in pregnant rat uterus'Japanese Journal of Pharmacology. (nii.ac.jp)
  • p Resumen en inglés Objective To assess the role of the anterior hypothalamic area in blood pressure regulation in a rat model of hypertension (HTN) and insulin resistance. (worldwidescience.org)
  • These studies suggested alternate regulatory routes that are independent of PKA and led to her consideration of the role of the vasoactive hormone adrenomedullin in the regulation of urea transporter and water channel activities. (emory.edu)
Role3
  • To clarify the role of adrenomedullin (AM) in the female reproductive system, we examined the effects of AM on periodic uterine contraction in nonpregnant and pregnant rats. (nii.ac.jp)
  • 3. The role of adrenomedullin and its receptor system in cardiovascular calcification of rat induced by Vitamin D(3) plus nicotine. (nih.gov)
  • 5 Adrenomedullin has also been identified as playing an important role in tumour pathogenesis. (bmj.com)
Effects1
  • REFERENCE 6 (residues 1 to 185) AUTHORS Allaker RP, Zihni C and Kapas S. TITLE An investigation into the antimicrobial effects of adrenomedullin on members of the skin, oral, respiratory tract and gut microflora JOURNAL FEMS Immunol. (nih.gov)
Biomarkers1
  • The partnership involves evaluation of biomarkers proenkephalin (penKid), proneurotensin (pro-NT), adrenomedullin (bio-ADM), and high-sensitivity growth hormone (vr-hGH). (medicaldevice-network.com)
Hormone1
  • Adrenomedullin (ADM) is a multifunctional hormone that regulates processes as diverse as blood pressure and cell growth. (elsevier.com)
Acute1
  • In part B of the study the highest dose that is considered safe and has demonstrated efficacy will be taken forward to collect information how well patients suffering from Acute Respiratory Distress Syndrome (ARDS) respond to treatment with inhaled pegylated adrenomedullin (PEG-ADM) compared to treatment with placebo. (centerwatch.com)
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