Adrenomedullin: A 52-amino acid peptide with multi-functions. It was originally isolated from PHEOCHROMOCYTOMA and ADRENAL MEDULLA but is widely distributed throughout the body including lung and kidney tissues. Besides controlling fluid-electrolyte homeostasis, adrenomedullin is a potent vasodilator and can inhibit pituitary ACTH secretion.Hydrops Fetalis: Abnormal accumulation of serous fluid in two or more fetal compartments, such as SKIN; PLEURA; PERICARDIUM; PLACENTA; PERITONEUM; AMNIOTIC FLUID. General fetal EDEMA may be of non-immunologic origin, or of immunologic origin as in the case of ERYTHROBLASTOSIS FETALIS.Capillary Permeability: The property of blood capillary ENDOTHELIUM that allows for the selective exchange of substances between the blood and surrounding tissues and through membranous barriers such as the BLOOD-AIR BARRIER; BLOOD-AQUEOUS BARRIER; BLOOD-BRAIN BARRIER; BLOOD-NERVE BARRIER; BLOOD-RETINAL BARRIER; and BLOOD-TESTIS BARRIER. Small lipid-soluble molecules such as carbon dioxide and oxygen move freely by diffusion. Water and water-soluble molecules cannot pass through the endothelial walls and are dependent on microscopic pores. These pores show narrow areas (TIGHT JUNCTIONS) which may limit large molecule movement.Systemic Inflammatory Response Syndrome: A systemic inflammatory response to a variety of clinical insults, characterized by two or more of the following conditions: (1) fever >38 degrees C or HYPOTHERMIA 90 beat/minute; (3) tachypnea >24 breaths/minute; (4) LEUKOCYTOSIS >12,000 cells/cubic mm or 10% immature forms. While usually related to infection, SIRS can also be associated with noninfectious insults such as TRAUMA; BURNS; or PANCREATITIS. If infection is involved, a patient with SIRS is said to have SEPSIS.Endothelial Cells: Highly specialized EPITHELIAL CELLS that line the HEART; BLOOD VESSELS; and lymph vessels, forming the ENDOTHELIUM. They are polygonal in shape and joined together by TIGHT JUNCTIONS. The tight junctions allow for variable permeability to specific macromolecules that are transported across the endothelial layer.Shock, Septic: Sepsis associated with HYPOTENSION or hypoperfusion despite adequate fluid resuscitation. Perfusion abnormalities may include, but are not limited to LACTIC ACIDOSIS; OLIGURIA; or acute alteration in mental status.Sepsis: Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.Cell Membrane Permeability: A quality of cell membranes which permits the passage of solvents and solutes into and out of cells.Endothelium, Vascular: Single pavement layer of cells which line the luminal surface of the entire vascular system and regulate the transport of macromolecules and blood components.Cells, Cultured: Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.Insulinoma: A benign tumor of the PANCREATIC BETA CELLS. Insulinoma secretes excess INSULIN resulting in HYPOGLYCEMIA.Peptides: Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.Receptors, Adrenomedullin: G-protein-coupled cell surface receptors for ADRENOMEDULLIN. They are formed by the heterodimerization of CALCITONIN RECEPTOR-LIKE PROTEIN and either RECEPTOR ACTIVITY-MODIFYING PROTEIN 2 or RECEPTOR ACTIVITY-MODIFYING PROTEIN 3.Abstracting and Indexing as Topic: Activities performed to identify concepts and aspects of published information and research reports.Data Mining: Use of sophisticated analysis tools to sort through, organize, examine, and combine large sets of information.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.MEDLINE: The premier bibliographic database of the NATIONAL LIBRARY OF MEDICINE. MEDLINE® (MEDLARS Online) is the primary subset of PUBMED and can be searched on NLM's Web site in PubMed or the NLM Gateway. MEDLINE references are indexed with MEDICAL SUBJECT HEADINGS (MeSH).PubMed: A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.Adenoma, Islet Cell: A benign tumor of the pancreatic ISLET CELLS. Usually it involves the INSULIN-producing PANCREATIC BETA CELLS, as in INSULINOMA, resulting in HYPERINSULINISM.Cardiomegaly: Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the left, or both HEART VENTRICLES or HEART ATRIA. Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES.Hypertrophy: General increase in bulk of a part or organ due to CELL ENLARGEMENT and accumulation of FLUIDS AND SECRETIONS, not due to tumor formation, nor to an increase in the number of cells (HYPERPLASIA).Hypertrophy, Left Ventricular: Enlargement of the LEFT VENTRICLE of the heart. This increase in ventricular mass is attributed to sustained abnormal pressure or volume loads and is a contributor to cardiovascular morbidity and mortality.Heart: The hollow, muscular organ that maintains the circulation of the blood.Myocardium: The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.Myocytes, Cardiac: Striated muscle cells found in the heart. They are derived from cardiac myoblasts (MYOBLASTS, CARDIAC).Fibrosis: Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other injury.Angiotensin II: An octapeptide that is a potent but labile vasoconstrictor. It is produced from angiotensin I after the removal of two amino acids at the C-terminal by ANGIOTENSIN CONVERTING ENZYME. The amino acid in position 5 varies in different species. To block VASOCONSTRICTION and HYPERTENSION effect of angiotensin II, patients are often treated with ACE INHIBITORS or with ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS.Myocardial Infarction: NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).Atrial Natriuretic Factor: A potent natriuretic and vasodilatory peptide or mixture of different-sized low molecular weight PEPTIDES derived from a common precursor and secreted mainly by the HEART ATRIUM. All these peptides share a sequence of about 20 AMINO ACIDS.Radioimmunoassay: Classic quantitative assay for detection of antigen-antibody reactions using a radioactively labeled substance (radioligand) either directly or indirectly to measure the binding of the unlabeled substance to a specific antibody or other receptor system. Non-immunogenic substances (e.g., haptens) can be measured if coupled to larger carrier proteins (e.g., bovine gamma-globulin or human serum albumin) capable of inducing antibody formation.Heart Failure: A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.Biological Markers: Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.Stroke Volume: The amount of BLOOD pumped out of the HEART per beat, not to be confused with cardiac output (volume/time). It is calculated as the difference between the end-diastolic volume and the end-systolic volume.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Aldosterone: A hormone secreted by the ADRENAL CORTEX that regulates electrolyte and water balance by increasing the renal retention of sodium and the excretion of potassium.Adrenocorticotropic Hormone: An anterior pituitary hormone that stimulates the ADRENAL CORTEX and its production of CORTICOSTEROIDS. ACTH is a 39-amino acid polypeptide of which the N-terminal 24-amino acid segment is identical in all species and contains the adrenocorticotrophic activity. Upon further tissue-specific processing, ACTH can yield ALPHA-MSH and corticotrophin-like intermediate lobe peptide (CLIP).Calcitonin Gene-Related Peptide: Calcitonin gene-related peptide. A 37-amino acid peptide derived from the calcitonin gene. It occurs as a result of alternative processing of mRNA from the calcitonin gene. The neuropeptide is widely distributed in neural tissue of the brain, gut, perivascular nerves, and other tissue. The peptide produces multiple biological effects and has both circulatory and neurotransmitter modes of action. In particular, it is a potent endogenous vasodilator.Blood Pressure: PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.Heart Rate: The number of times the HEART VENTRICLES contract per unit of time, usually per minute.Protein PrecursorsExercise: Physical activity which is usually regular and done with the intention of improving or maintaining PHYSICAL FITNESS or HEALTH. Contrast with PHYSICAL EXERTION which is concerned largely with the physiologic and metabolic response to energy expenditure.Exercise Test: Controlled physical activity which is performed in order to allow assessment of physiological functions, particularly cardiovascular and pulmonary, but also aerobic capacity. Maximal (most intense) exercise is usually required but submaximal exercise is also used.Physical Exertion: Expenditure of energy during PHYSICAL ACTIVITY. Intensity of exertion may be measured by rate of OXYGEN CONSUMPTION; HEAT produced, or HEART RATE. Perceived exertion, a psychological measure of exertion, is included.ArchivesBiological Science Disciplines: All of the divisions of the natural sciences dealing with the various aspects of the phenomena of life and vital processes. The concept includes anatomy and physiology, biochemistry and biophysics, and the biology of animals, plants, and microorganisms. It should be differentiated from BIOLOGY, one of its subdivisions, concerned specifically with the origin and life processes of living organisms.Cumulus Cells: The granulosa cells of the cumulus oophorus which surround the OVUM in the GRAAFIAN FOLLICLE. At OVULATION they are extruded with OVUM.Directories as Topic: Lists of persons or organizations, systematically arranged, usually in alphabetic or classed order, giving address, affiliations, etc., for individuals, and giving address, officers, functions, and similar data for organizations. (ALA Glossary of Library and Information Science, 1983)Publishing: "The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.Serial Publications: Publications in any medium issued in successive parts bearing numerical or chronological designations and intended to be continued indefinitely. (ALA Glossary of Library and Information Science, 1983, p203)Ventilator-Induced Lung Injury: Lung damage that is caused by the adverse effects of PULMONARY VENTILATOR usage. The high frequency and tidal volumes produced by a mechanical ventilator can cause alveolar disruption and PULMONARY EDEMA.Lung Injury: Damage to any compartment of the lung caused by physical, chemical, or biological agents which characteristically elicit inflammatory reaction. These inflammatory reactions can either be acute and dominated by NEUTROPHILS, or chronic and dominated by LYMPHOCYTES and MACROPHAGES.Lung: Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.Ventilators, Mechanical: Mechanical devices used to produce or assist pulmonary ventilation.Acute Lung Injury: A condition of lung damage that is characterized by bilateral pulmonary infiltrates (PULMONARY EDEMA) rich in NEUTROPHILS, and in the absence of clinical HEART FAILURE. This can represent a spectrum of pulmonary lesions, endothelial and epithelial, due to numerous factors (physical, chemical, or biological).Respiration, Artificial: Any method of artificial breathing that employs mechanical or non-mechanical means to force the air into and out of the lungs. Artificial respiration or ventilation is used in individuals who have stopped breathing or have RESPIRATORY INSUFFICIENCY to increase their intake of oxygen (O2) and excretion of carbon dioxide (CO2).Respiratory Distress Syndrome, Adult: A syndrome characterized by progressive life-threatening RESPIRATORY INSUFFICIENCY in the absence of known LUNG DISEASES, usually following a systemic insult such as surgery or major TRAUMA.Tidal Volume: The volume of air inspired or expired during each normal, quiet respiratory cycle. Common abbreviations are TV or V with subscript T.Cytokines: Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner.
(1/693) Role of nitric oxide-cGMP pathway in adrenomedullin-induced vasodilation in the rat.

We previously reported that adrenomedullin (AM), a potent vasodilator peptide discovered in pheochromocytoma cells, stimulates nitric oxide (NO) release in the rat kidney. To further investigate whether the NO-cGMP pathway is involved in the mechanisms of AM-induced vasodilation, we examined the effects of E-4021, a cGMP-specific phosphodiesterase inhibitor, on AM-induced vasorelaxation in aortic rings and perfused kidneys isolated from Wistar rats. We also measured NO release from the kidneys using a chemiluminescence assay. AM (10(-10) to 10(-7) mol/L) relaxed the aorta precontracted with phenylephrine in a dose-dependent manner. Denudation of endothelium (E) attenuated the vasodilatory action of AM (10(-7) mol/L AM: intact (E+) -25.7+/-5.2% versus denuded (E-) -7. 8+/-0.6%, P<0.05). On the other hand, pretreatment with 10(-8) mol/L E-4021 augmented AM-induced vasorelaxation in the intact aorta (-49. 0+/-7.9%, P<0.05) but not in the denuded one. E-4021 also enhanced acetylcholine (ACh)-induced vasorelaxation in the rat intact aorta (10(-7) mol/L ACh -36.6+/-8.4% versus 10(-8) mol/L E-4021+10(-7) mol/L ACh -62.7+/-3.1%, P<0.05). In perfused kidneys, AM-induced vasorelaxation was also augmented by preincubation with E-4021 (10(-9) mol/L AM -15.4+/-0.6% versus 10(-8) mol/L E-4021+10(-9) mol/L AM -23.6+/-1.2%, P<0.01). AM significantly increased NO release from rat kidneys (DeltaNO: +11.3+/-0.8 fmol. min-1. g-1 kidney at 10(-9) mol/L AM), which was not affected by E-4021. E-4021 enhanced ACh-induced vasorelaxation (10(-9) mol/L ACh -9.7+/-1.7% versus 10(-8) mol/L E-4021+10(-9) mol/L ACh -18.8+/-2.9%, P<0.01) but did not affect ACh-induced NO release from the kidneys. In the aorta and the kidney, 10(-4) mol/L of NG-nitro-L-arginine methyl ester, an NO synthase inhibitor, and 10(-5) mol/L of methylene blue, a guanylate cyclase inhibitor, reduced the vasodilatory effect of AM. These results suggest that the NO-cGMP pathway is involved in the mechanism of AM-induced vasorelaxation, at least in the rat aorta and kidney.  (+info)

(2/693) Adrenomedullin is upregulated in the heart and aorta during the early and late stages of sepsis.

Although circulating levels of adrenomedullin (ADM), a newly reported vasodilatory peptide with 52 amino acid residues in the human and 50 amino acid residues in the rat, are elevated during the early and late stages of sepsis, ADM levels in cardiovascular tissues and its precise localization remain to be determined. To study this, rats were subjected to sepsis by cecal ligation and puncture (CLP), followed by administration of 3 ml/100 g b.wt. normal saline to these and sham-operated animals. The heart and thoracic aorta were harvested at 5 h (i.e. the early stage of sepsis) and 20 h (late sepsis) after CLP. Tissue levels of ADM were determined by radioimmunoassay. The localization of ADM in the left ventricle and thoracic aorta was examined by using immunohistochemistry and electron microscopy techniques. The results indicated that ADM levels in the heart and thoracic aorta increased significantly at 5 h after CLP and remained elevated at 20 h after the onset of sepsis. Immunohistochemistry findings showed that ADM immunoreaction products were localized in the cytoplasm of the cardiac myocytes and aortic endothelial cells. Using electron microscopy, ADM immunoreaction products were found in the cytoplasmic matrixes. The immunostainings were also associated with the outer membranes of mitochondria and vesicles of the myocytes as well as vascular endothelial cells. It appears that the cardiovascular tissues, among other organ systems, contribute to the increased levels of plasma ADM under those conditions. Since ADM is localized in different cell populations in the heart and the large blood vessel (i.e. myocytes versus vascular endothelial cells), this peptide may play a differential role in regulating cardiac and vascular functions during sepsis as an autocrine and/or paracrine mediator.  (+info)

(3/693) Proadrenomedullin N-terminal 20 peptide hyperpolarizes the membrane by activating an inwardly rectifying K+ current in differentiated PC12 cells.

The mechanism of proadrenomedullin N-terminal 20 peptide (PAMP)-induced inhibition of catecholamine release from adrenergic nerve was investigated in nerve growth factor-treated PC12 cells that have differentiated characteristics somewhat similar to noradrenergic neurons. The effect of PAMP on the excitability of these cells was investigated with the use of perforated whole-cell clamp. PAMP hyperpolarized the membrane by increasing a K+ conductance in a dose-dependent manner. The current-voltage relationship (I-V) relationship of the PAMP-induced K+ conductance exhibited inward-going rectification. The activation was abolished by microinjecting GDPbetaS into the cells or pretreating the cells with pertussis toxin. These results indicate that a pertussis toxin-sensitive G protein is involved in the signal transduction. The PAMP-induced activation of the K+ conductance was attenuated by microinjecting antibody against the carboxyl terminus of Galphai3, but it was not influenced by microinjecting antibody against the common carboxyl termini of Galphai1 and Galphai2, which indicated that the G protein coupling the PAMP receptor to the inwardly rectifying K+ current is Galphai3. The PAMP-induced hyperpolarization may inhibit the catecholamine release from the neurons by attenuating the action potential frequency.  (+info)

(4/693) Coronary sinus adrenomedullin rises in response to myocardial injury.

Human adrenomedullin (ADM), a peptide comprising 52 amino acids, is a circulating hormone with vasodilator properties. We have evaluated its release by the heart following ischaemic myocardial damage, as indicated by elevated levels of the cardiospecific protein troponin-T (Tn-T) during cardiopulmonary bypass. ADM (pg/ml) and Tn-T (ng/ml) were measured in coronary sinus blood before and after aortic cross-clamp and in venous blood 6 h after surgery in 22 coronary-bypass patients. Based on the pre- and post-clamp Tn-T levels in the coronary sinus, the patients were divided into group I (no change; n=10) and group II (two times increase; n=12). Baseline ADM (362.7+/-106.2 and 303+/-58.7 pg/ml in groups I and II respectively; means+/-S.D.) and Tn-T (0.66+/-0.14 and 0.57+/-0.13 ng/ml respectively) levels were similar in both groups. In group I, the post-clamp ADM (317.6+/-80.8 pg/ml) and Tn-T (0.68+/-0.15 ng/ml) levels did not change significantly. In group II, the post-clamp ADM levels rose significantly above the baseline, mimicking the change in Tn-T (ADM, 541.4+/-89.4 pg/ml; Tn-T, 1.37+/-0.31 ng/ml; P=0.009). After 6 h, the systemic Tn-T levels were similar in both groups (2. 09+/-0.44 and 1.95+/-0.52 ng/ml in groups I and II respectively). We suggest that: (1) minor degrees of myocardial ischaemic damage result in release of ADM by the heart, and (2) ADM may play a protective role in the myocardium during an ischaemic insult. This suggests a possible therapeutic role for ADM in the management of intra-operative myocardial ischaemia.  (+info)

(5/693) Effects of adrenomedullin and PAMP on adrenal catecholamine release in dogs.

We examined the effects of proadrenomedullin-derived peptides on the release of adrenal catecholamines in response to cholinergic stimuli in pentobarbital sodium-anesthetized dogs. Drugs were administered into the adrenal gland through the phrenicoabdominal artery. Splanchnic nerve stimulation (1, 2, and 3 Hz) and ACh injection (0.75, 1.5, and 3 microgram) produced frequency- or dose-dependent increases in adrenal catecholamine output. These responses were unaffected by infusion of adrenomedullin (1, 3, and 10 ng. kg-1. min-1) or its selective antagonist adrenomedullin-(22-52) (5, 15, and 50 ng. kg-1. min-1). Proadrenomedullin NH2-terminal 20 peptide (PAMP; 5, 15, and 50 ng. kg-1. min-1) suppressed both the splanchnic nerve stimulation- and ACh-induced increases in catecholamine output in a dose-dependent manner. PAMP also suppressed the catecholamine release responses to the nicotinic agonist 1, 1-dimethyl-4-phenylpiperazinium (0.5, 1, and 2 microgram) and to muscarine (0.5, 1, and 2 microgram), although the muscarine-induced response was relatively resistant to PAMP. These results suggest that PAMP, but not adrenomedullin, can act as an inhibitory regulator of adrenal catecholamine release in vivo.  (+info)

(6/693) Hypoxia-induced adrenomedullin production in the kidney.

BACKGROUND: Adrenomedullin (AM) is a newly discovered peptide that has a potent vasorelaxant activity. To investigate its potential roles in hypoxia-induced renal injury, we examined whether AM production in the kidney increased under hypoxic conditions. METHODS: The AM transcript levels in Madin-Darby canine kidney (MDCK) cells, rat vascular smooth muscle cells (VSMCs), and rat mesangial cells were assessed by Northern blot analyses under normoxic and hypoxic conditions. The AM peptide in culture media was measured by radioimmunoassay. The effects of hypoxia on accumulation of cAMP in VSMCs were also examined. The stability of AM transcripts under normoxic and hypoxic conditions was compared in the presence of actinomycin D. The effects of hypoxia on AM promoter activity was assessed by transient transfection assays using the AM promoter subcloned upstream of luciferase gene. RESULTS: The expression of AM transcripts increased significantly in MDCK cells, rat VSMCs, and rat mesangial cells under hypoxic conditions without changes in the stability of AM transcripts; however, the AM promoter activity under hypoxic was not elevated significantly. The accumulation of AM peptide in culture media also increased significantly under hypoxic conditions in MDCK cells (2.2 +/- 0.1 fmol/10(5) cells in normoxia vs. 3.5 +/- 0.3 fmol/10(5) cells in hypoxia, 6 hr after hypoxia induction, P < 0.001), and in rat VSMCs (5.5 +/- 0.3 fmol/10(5) cells in normoxia vs. 7.8 +/- 0.4 fmol/10(5) cells in hypoxia, 8 hr after hypoxia induction, P < 0.01). Under hypoxic conditions, cAMP levels in rat VSMCs increased significantly compared with those under normoxic conditions (13.3 +/- 1.4 pmol/well vs. 4.6 +/- 0.4 pmol/well, P < 0.01). CONCLUSIONS: Renal parenchymal cells as well as renal vessels may produce AM under hypoxic conditions.  (+info)

(7/693) Characterization of receptors for calcitonin gene-related peptide and adrenomedullin on the guinea-pig vas deferens.

1. The receptors which mediate the effects of calcitonin gene-related peptide (CGRP), amylin and adrenomedullin on the guinea-pig vas deferens have been investigated. 2. All three peptides cause concentration dependant inhibitions of the electrically stimulated twitch response (pD2s for CGRP, amylin and adrenomedullin of 7.90+/-0.11, 7.70+/-0.19 and 7.25+/-0.10 respectively). 3. CGRP8-37 (1 microM) and AC187 (10 microM) showed little antagonist activity against adrenomedullin. 4. Adrenomedullin22-52 by itself inhibited the electrically stimulated contractions of the vas deferens and also antagonized the responses to CGRP, amylin and adrenomedullin. 5. [125I]-adrenomedullin labelled a single population of binding sites in vas deferens membranes with a pIC50 of 8.91 and a capacity of 643 fmol mg(-1). Its selectivity profile was adrenomedullin> AC187>CGRP=amylin. It was clearly distinct from a site labelled by [125I]-CGRP (pIC50=8.73, capacity=114 fmol mg(-1), selectivity CGRP>amylin=AC187>adrenomedullin). [125I]-amylin bound to two sites with a total capacity of 882 fmol mg(-1). 6. Although CGRP has been shown to act at a CGRP2 receptor on the vas deferens with low sensitivity to CGRP8-37, this antagonist displaced [125I]-CGRP with high affinity from vas deferens membranes. This affinity was unaltered by increasing the temperature from 4 degrees C to 25 degrees C, suggesting the anomalous behaviour of CGRP8-37 is not due to temperature differences between binding and functional assays.  (+info)

(8/693) Central adrenomedullin augments the baroreceptor reflex in conscious rabbits.

We examined the roles of central adrenomedullin, proadrenomedullin N-terminal 20 peptide (PAMP), and calcitonin gene-related peptide (CGRP) on the baroreceptor reflex in conscious rabbits. Intracerebroventricular injection of adrenomedullin (0.2 and 1 nmol/80 microL) elicited dose-related increases in arterial pressure and renal sympathetic nerve activity. On the other hand, a subpressor dose of intracerebroventricular infusion of adrenomedullin (1 nmol/300 microL per hour) caused significant increases in baroreflex sensitivities assessed by renal sympathetic nerve activity and heart rate compared with vehicle infusion (Gmax; -14.9+/-1.7 versus -8.0+/-0.7%/mm Hg, P<0.01, and -8.1+/-0.8 versus -5.1+/-0.5 bpm/mm Hg, P<0.01, respectively). Intracerebroventricular infusion of CGRP (1 nmol/300 microL per hour), which is structurally homologous to adrenomedullin, also enhanced the baroreflex controls of renal sympathetic nerve activity and heart rate. However, the intracerebroventricular infusion of PAMP (30 nmol/300 microL per hour) failed to alter the baseline levels of arterial pressure and baroreflex sensitivities. These results suggest that central adrenomedullin and CGRP, but not PAMP, participate in cardiovascular regulation to augment the baroreflex controls of renal sympathetic nerve activity and heart rate in conscious rabbits.  (+info)

*  Adrenomedullin
... (ADM or AM) is a vasodilator peptide hormone of uncertain significance in human health and disease. It was ... The adrenomedullin knockout is an embryonic lethal phenotype and dies mid gestation from a condition known as hydrops fetalis. ... Adrenomedullin at the US National Library of Medicine Medical Subject Headings (MeSH) Human ADM genome location and ADM gene ... "Entrez Gene: Adrenomedullin". Meeran K, O'Shea D, Upton PD, Small CJ, Ghatei MA, Byfield PH, Bloom SR (January 1997). " ...
*  ADM2
"Entrez Gene: ADM2 adrenomedullin 2". Human ADM2 genome location and ADM2 gene details page in the UCSC Genome Browser. Kawai M ... 2006). "Immunocytochemical localization of adrenomedullin 2/intermedin-like immunoreactivity in human hypothalamus, heart and ... "Identification of novel adrenomedullin in mammals: a potent cardiovascular and renal regulator". FEBS Lett. 556 (1-3): 53-8. ...
*  RAMP2
In the presence of this (RAMP2) protein, CRLR functions as an adrenomedullin receptor. The RAMP2 protein is involved in core ... Fritz-Six KL, Dunworth WP, Li M, Caron KM (January 2008). "Adrenomedullin signaling is necessary for murine lymphatic vascular ... Kuwasako K, Kitamura K, Nagoshi Y, Eto T (2003). "Novel calcitonin-(8-32)-sensitive adrenomedullin receptors derived from co- ... 2008). "Lack of linkage and association of adrenomedullin and its receptor genes in French Caucasian rheumatoid arthritis trio ...
*  Sodium nitroprusside
"Possible role of nitric oxide and adrenomedullin in bipolar affective disorder". Neuropsychobiology. 45 (2): 57-61. doi:10.1159 ...
*  Calcitonin gene-related peptide
The mammalian calcitonin gene-related peptides, adrenomedullin, amylin, and calcitonin receptors". Pharmacol Rev. 54 (2): 233- ...
*  RAMP3
Kuwasako K, Kitamura K, Nagoshi Y, Eto T (2003). "Novel calcitonin-(8-32)-sensitive adrenomedullin receptors derived from co- ... In the presence of this (RAMP3) protein, CRLR functions as an adrenomedullin receptor. GRCh38: Ensembl release 89: ... 2005). "Receptor activity-modifying protein (RAMP) isoform-specific regulation of adrenomedullin receptor trafficking by NHERF- ... receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. ...
*  BCL2L10
Li Z, Takeuchi S, Ohara N, Maruo T (2003). "Paradoxically abundant expression of Bcl-2 and adrenomedullin in invasive cervical ...
*  Chromogranin A
"High plasma levels of human chromogranin A and adrenomedullin in patients with pheochromocytoma". Tumori. 91 (1): 53-8. PMID ...
*  GPR182
1998). "Expression of the rat adrenomedullin receptor or a putative human adrenomedullin receptor does not correlate with ... 2004). "[Study of the expression and role of adrenomedullin and adrenomedullin receptor in patients with chronic obstructive ... of the rat adrenomedullin receptor or a putative human adrenomedullin receptor does not correlate with adrenomedullin binding ... 1997). "Expression of adrenomedullin and its receptor in normal and malignant human skin: a potential pluripotent role in the ...
*  RCP9
2000). "CGRP-RCP, a novel protein required for signal transduction at calcitonin gene-related peptide and adrenomedullin ... in adrenomedullin receptor signal transduction". Peptides. 22 (11): 1773-81. doi:10.1016/S0196-9781(01)00517-4. PMID 11754963. ...
*  Eclampsia
Li H, Dakour J, Kaufman S, Guilbert LJ, Winkler-Lowen B, Morrish DW (November 2003). "Adrenomedullin is decreased in ... The placenta produces the potent vasodilator adrenomedullin: it is reduced in pre-eclampsia and eclampsia. Other vasodilators ...
*  RAMP1
Kuwasako K, Kitamura K, Nagoshi Y, Eto T (2003). "Novel calcitonin-(8-32)-sensitive adrenomedullin receptors derived from co- ... 2004). "Tumor necrosis factor-alpha downregulates adrenomedullin receptors in human coronary artery smooth muscle cells". ... receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In combination with the ... adrenomedullin, and amylin receptor function". Mol. Pharmacol. 74 (4): 1059-71. doi:10.1124/mol.108.047142. PMID 18593822. " ...
*  Stress in medical students
Stress can cause high levels of the following hormones: norepinephrine, leptin, NPY, nitrite, ACTH and adrenomedullin. Elevated ...
*  CALCRL
Born W, Muff R, Fischer JA (2002). "Functional interaction of G protein-coupled receptors of the adrenomedullin peptide family ... 1999). "The RAMP2/CRLR complex is a functional adrenomedullin receptor in human endothelial and vascular smooth muscle cells". ... 2000). "CGRP-RCP, a novel protein required for signal transduction at calcitonin gene-related peptide and adrenomedullin ... Hill H, Pioszak A (2013). "Bacterial expression and purification of a heterodimeric adrenomedullin receptor extracellular ...
*  Receptor activity-modifying protein
The likelihood is that the phenotype of RAMP2 KO mice is more connected with the abolition of most adrenomedullin (AM) ... "The RAMP2/CRLR complex is a functional adrenomedullin receptor in human endothelial and vascular smooth muscle cells". FEBS ...
*  Factor H
... and physiological actions of factor H as an adrenomedullin binding protein present in human plasma". Microscopy Research and ...
*  Sacubitril/valsartan
... and adrenomedullin. Thus, sacubitril increases the levels of these peptides, causing blood vessel dilation and reduction of ECF ...
*  Natriuretic peptide precursor C
2002). "Effects of endothelin-1 on release of adrenomedullin and C-type natriuretic peptide from individual human vascular ...
*  Debbie Lucy Hay
"CL/RAMP2 and CL/RAMP3 produce pharmacologically distinct adrenomedullin receptors: a comparison of effects of adrenomedullin22- ...
*  Atrial natriuretic peptide
... and adrenomedullin. Neutral endopeptidase (NEP) also known as neprilysin is the enzyme that metabolizes natriuretic peptides. ...
*  Calcitonin
... and the precursor of adrenomedullin. Secretion of calcitonin is stimulated by: an increase in serum [Ca2+] gastrin and ...
*  Neuroendocrine differentiation
... and adrenomedullin. The physiology of their secretion and its regulation is incompletely understood. Regulatory cues might come ...
*  ADM
... a computer terminal manufactured by Lear Siegler Adrenomedullin, a vasodilator peptide hormone of uncertain significance in ...
*  Amylin family
... and adrenomedullin. Calcitonin is a 32 amino acid polypeptide hormone that causes a rapid but short-lived drop in the level of ...
*  Rhodopsin-like receptors
Adrenomedullin receptor (GPR182) Duffy blood group, chemokine receptor (DARC, DUFF) G Protein-coupled Receptor 30 (GPER, CML2, ...
Plasma adrenomedullin as an indicator of prognosis after acute myocardial infarction | Heart  Plasma adrenomedullin as an indicator of prognosis after acute myocardial infarction | Heart
Immunoreactive adrenomedullin has been detected in human plasma, and human adrenomedullin messenger RNA has been reported to be ... PLASMA ADRENOMEDULLIN AND CLINICAL, HAEMODYNAMIC, AND CARDIAC FUNCTION VARIABLES. Plasma adrenomedullin on day 2 was ... In the present study, we examined the prognostic value of plasma adrenomedullin on day 2, because plasma adrenomedullin ... Plasma adrenomedullin in non-survivors was markedly increased compared with survivors (fig 1). Plasma adrenomedullin correlated ...
more infohttp://heart.bmj.com/content/81/5/483
Effect of prolonged dynamic exercise on plasma adrenomedullin concentration in healthy young men.  Effect of prolonged dynamic exercise on plasma adrenomedullin concentration in healthy young men.
The aim of the study was to find out whether prolonged exercise influences plasma adrenomedullin (ADM) concentration and ... Adrenomedullin / blood*. Adult. Blood Pressure / physiology. Exercise / physiology*. Exercise Test. Heart Rate / physiology. ... The aim of the study was to find out whether prolonged exercise influences plasma adrenomedullin (ADM) concentration and ...
more infohttp://www.biomedsearch.com/nih/Effect-prolonged-dynamic-exercise-plasma/17229982.html
Comment on: Harmancey et al. (2007) Adrenomedullin Inhibits Adipogenesis Under Transcriptional Control of Insulin: Diabetes 56...  Comment on: Harmancey et al. (2007) Adrenomedullin Inhibits Adipogenesis Under Transcriptional Control of Insulin: Diabetes 56...
1) on inhibition of adipogenesis by adrenomedullin. Previous studies, including ours (2-4), have shown that adrenomedullin is ... the authors placed too much emphasis on the inhibition of adrenomedullin expression by insulin in adipocytes. Adrenomedullin ... 1 in article). The adrenomedullin concentrations in the medium of cultured adipocytes rarely exceed 1 nmol/l (2,4). Second, the ... Li Y, Totsune K, Takeda K, Furuyama K, Shibahara S, Takahashi K: Differential expression of adrenomedullin and resistin in 3T3- ...
more infohttp://diabetes.diabetesjournals.org/content/56/9/e15
Modulation of cytokine responses by adrenomedullin and adrenomedullin binding protein-1 in macrophages: a novel pathway in...  Modulation of cytokine responses by adrenomedullin and adrenomedullin binding protein-1 in macrophages: a novel pathway in...
Modulation of cytokine responses by adrenomedullin and adrenomedullin binding protein-1 in macrophages: a novel pathway in ... 1. Adrenomedullin augments the production of interleukin-10, a cytokine that limits inflammation.. 2. Interferon-γ, a cytokine ... 3. Cyclic AMP mediates the increased expression of adrenomedullin, interleukin-6, and interleukin-10 in response to endotoxin. ... that is increased in inflammation, downregulates the receptor and binding protein of adrenomedullin.. ...
more infohttp://www.hkmj.org/abstracts/v21%20Suppl%204n/39.htm
Adrenomedullin - Wikipedia  Adrenomedullin - Wikipedia
Adrenomedullin (ADM or AM) is a vasodilator peptide hormone of uncertain significance in human health and disease. It was ... The adrenomedullin knockout is an embryonic lethal phenotype and dies mid gestation from a condition known as hydrops fetalis. ... Adrenomedullin at the US National Library of Medicine Medical Subject Headings (MeSH) Human ADM genome location and ADM gene ... "Entrez Gene: Adrenomedullin". Meeran K, O'Shea D, Upton PD, Small CJ, Ghatei MA, Byfield PH, Bloom SR (January 1997). " ...
more infohttps://en.wikipedia.org/wiki/Adrenomedullin
Adrenomedullin in heart failure: potential therapeutic implications.  - PubMed - NCBI  Adrenomedullin in heart failure: potential therapeutic implications. - PubMed - NCBI
Adrenomedullin in heart failure: potential therapeutic implications.. Charles CJ1, Rademaker MT, Nicholls MG, Richards AM. ... Adrenomedullin (AM) may play a role in the pathophysiology of heart failure. Plasma levels of AM are raised in cardiovascular ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed?cmd=search&term=19804168
Adrenomedullin | Springer for Research & Development  Adrenomedullin | Springer for Research & Development
Hinson JP, Kapas S, Smith DM (2000) Adrenomedullin, a multifunctional regulatory peptide. Endocr Rev 21:138-167PubMedGoogle ... Adrenomedullin wurde im Jahr 1993 erstmalig aus einem Phäochromozytom im Nebenierenmark extrahiert. Nach der „adrenal medulla" ... Adrenomedullin ist ein Peptid aus 52 Aminosäuren mit zahlreichen Wirkungen auf Herz-Kreislauf-System, Hormonsysteme, Atmung, ... Hubl W. (2019) Adrenomedullin. In: Gressner A.M., Arndt T. (eds) Lexikon der Medizinischen Laboratoriumsdiagnostik. Springer ...
more infohttps://rd.springer.com/chapter/10.1007%2F978-3-662-48986-4_104
Adrenomedullin: a novel hypotensive peptide isolated from human pheochromocytoma.  - PubMed - NCBI  Adrenomedullin: a novel hypotensive peptide isolated from human pheochromocytoma. - PubMed - NCBI
These data suggest that adrenomedullin is a new hormone participating in blood pressure control. Occurrence of adrenomedullin ... Adrenomedullin: a novel hypotensive peptide isolated from human pheochromocytoma.. Kitamura K1, Kangawa K, Kawamoto M, Ichiki Y ... "adrenomedullin". The peptide, consisting of 52 amino acids, has one intramolecular disulfide bond and shows slight homology ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/8387282?dopt=Abstract
Adrenomedullin Reduces Endothelial Hyperpermeability | Circulation Research  Adrenomedullin Reduces Endothelial Hyperpermeability | Circulation Research
Adrenomedullin Reduces Endothelial Hyperpermeability. Stefan Hippenstiel, Martin Witzenrath, Bernd Schmeck, Andreas Hocke, ... Adrenomedullin acts via stimulation of cyclic AMP and not via calcium signalling in vascular cells in culture. J Hum Hypertens ... Adrenomedullin and the control of fluid and electrolyte homeostasis. Annu Rev Physiol. 1999; 61: 363-389. ... Vijay P. Adrenomedullin in the treatment of pulmonary hypertension. Heart. 2000; 84: 575-576. ...
more infohttp://circres.ahajournals.org/content/91/7/618
Adrenomedullin, a new peptide, in patients with insulinoma. | Sigma-Aldrich  Adrenomedullin, a new peptide, in patients with insulinoma. | Sigma-Aldrich
... plasma adrenomedullin decreased from 6.3 +/- 2.9 fmol/ml to 3.0 +/- 1.6 fmol/ml. Immunoreactive adrenomedullin was localized ... Adrenomedullin, a new peptide, in patients with insulinoma.. [C Letizia, G Tamburrano, P Alo, A Paoloni, C Caliumi, E Marinoni ... To investigate whether adrenomedullin secretion is modified in patients with insulin-secreting islet cell tumours. The study ... Circulating adrenomedullin was assayed using a specific radioimmunoassay and its localization and distribution in the tumour ...
more infohttps://www.sigmaaldrich.com/catalog/papers/11331218
Catalog Peptides  Catalog Peptides
a leading provider for Adrenomedullin Peptides, Chemotactic Peptides, Melanotan Peptides, Ova Peptides, Obesity Peptides, ...
more infohttps://www.biosyn.com/catalog-peptides.aspx
Adrenomedullin attenuates ventilator-induced lung injury in mice | Thorax  Adrenomedullin attenuates ventilator-induced lung injury in mice | Thorax
Results Adrenomedullin dramatically reduced lung permeability in VILI in mice, leading to improved oxygenation. Adrenomedullin ... Adrenomedullin reduces vascular hyperpermeability and improves survival in rat septic shock. Intensive Care Med 2007;33:703-10. ... Mice were ventilated with a tidal volume (VT) of 12 ml/kg for 6 h (6 h vent). Adrenomedullin was infused for 4 h starting 2 h ... Adrenomedullin ameliorates lipopolysaccharide-induced acute lung injury in rats. Am J Physiol Lung Cell Mol Physiol 2007;293: ...
more infohttps://thorax.bmj.com/content/65/12/1077
Adrenomedullin in Cardiovascular Disease | Springer for Research & Development  Adrenomedullin in Cardiovascular Disease | Springer for Research & Development
Adrenomedullin has attracted considerable interest among cardiologists due ... Adrenomedullin was discovered in 1993 in an extract of human pheochromocytoma while monitoring cAMP levels in rat platelets. ... Adrenomedullin in Cardiovascular Disease is an up-to-date review of the most relevant aspects of adrenomedullin. It encompasses ... Pleiotropic Effect of Adrenomedullin: Lessons from Pure Adrenomedullin Knockout Mouse Tatsuo Shimosawa, Katsuyuki Ando, Toshiro ...
more infohttps://rd.springer.com/book/10.1007/b107323
Targeting Adrenomedullin to Improve Lipid Homeostasis in Diabetic Pregnancies  Targeting Adrenomedullin to Improve Lipid Homeostasis in Diabetic Pregnancies
To determine the role of adrenomedullin (AM), a multifunctional peptide, in lipid metabolism in GDM. ...
more infohttps://insights.ovid.com/pubmed?PMID=28666334
Adrenomedullin modulates TGF-beta1 and beta1-induced MMP-2 in HSCs - ScienceBlog.com  Adrenomedullin modulates TGF-beta1 and beta1-induced MMP-2 in HSCs - ScienceBlog.com
Adrenomedullin (AM) may intervene the activation of hepatic stellate cells by inhibiting TGF-beta1 production and TGF-beta1- ... Home Uncategorized Adrenomedullin modulates TGF-beta1 and beta1-induced MMP-2 in HSCs ... Adrenomedullin modulates TGF-beta1 and beta1-induced MMP-2 in HSCs. July 23, 2006. ...
more infohttps://scienceblog.com/11076/adrenomedullin-modulates-tgf-beta1-and-beta1-induced-mmp-2-in-hscs/
ADM (adrenomedullin) - KOMP (Knockout Mouse Project)  ADM (adrenomedullin) - KOMP (Knockout Mouse Project)
OMIM: ADRENOMEDULLIN; ADM, HYDROPS FETALIS, IDIOPATHIC*Gene Ontology: Adm *Mouse Phenome DB: Adm *UCSC: Chr.7:110,627,669- ... adrenomedullin. Synonyms: AM. Gene nomenclature, locus information, and GO, OMIM, and PMID associations are updated daily from ...
more infohttps://www.komp.org/geneinfo.php?geneid=18430
Sphingotec reveals novel results on bioactive adrenomedullin at the 39th ISICEM | EurekAlert! Science News  Sphingotec reveals novel results on bioactive adrenomedullin at the 39th ISICEM | EurekAlert! Science News
Hennigsdorf/Berlin - Diagnostics company sphingotec GmbH reports novel applications of bio-ADM® (bio-active adrenomedullin), ... Sphingotec reveals novel results on bioactive adrenomedullin at the 39th ISICEM. sphingotec GmbH ...
more infohttps://eurekalert.org/pub_releases/2019-03/sg-srn031919.php
Anti-Inflammatory Effects of Adrenomedullin on Acute Lung Injury Induced by Carrageenan in Mice  Anti-Inflammatory Effects of Adrenomedullin on Acute Lung Injury Induced by Carrageenan in Mice
Adrenomedullin (AM) is a 52 amino acid peptide that has shown predominant anti-inflammatory activities. In the present study, ... Anti-Inflammatory Effects of Adrenomedullin on Acute Lung Injury Induced by Carrageenan in Mice. Talero Elena,1 Di Paola ...
more infohttps://www.hindawi.com/journals/mi/2012/717851/abs/
Comparative actions of adrenomedullin and nitroprusside: interactions with ANG II and norepinephrine.  Comparative actions of adrenomedullin and nitroprusside: interactions with ANG II and norepinephrine.
The role of adrenomedullin (ADM) in volume and pressure homeostasis remains undefined. Accordingly, we compared the biological ... Adrenomedullin. Angiotensin II / metabolism*. Animals. Atrial Natriuretic Factor / metabolism. Blood Pressure / drug effects. ... The role of adrenomedullin (ADM) in volume and pressure homeostasis remains undefined. Accordingly, we compared the biological ... 0/Endothelins; 0/Peptides; 11128-99-7/Angiotensin II; 114471-18-0/Natriuretic Peptide, Brain; 148498-78-6/Adrenomedullin; 15078 ...
more infohttp://www.biomedsearch.com/nih/Comparative-actions-adrenomedullin-nitroprusside-interactions/11705774.html
Protective Effects of Endogenous Adrenomedullin on Cardiac Hypertrophy, Fibrosis, and Renal Damage | Circulation  Protective Effects of Endogenous Adrenomedullin on Cardiac Hypertrophy, Fibrosis, and Renal Damage | Circulation
Adrenomedullin expression in human tumor cell lines: its potential role as an autocrine growth factor. J Biol Chem. 1996; 271: ... Effects of adrenomedullin on cultured rat cardiac myocytes and fibroblasts. Eur J Pharmacol. 1999; 382: 1-9. ... Adrenomedullin (AM) is a vasodilator peptide originally isolated from the extract of human pheochromocytoma.1 It has also been ... Adrenomedullin: a possible autocrine or paracrine inhibitor of hypertrophy of cardiomyocytes. Hypertension. 1998; 31: 505-510. ...
more infohttp://circ.ahajournals.org/content/109/14/1789
  • Adrenomedullin-2 (intermedin, 148 aa) may regulate gastrointestinal and cardiovascular activities through a cAMP-dependent pathway. (oup.com)
  • Based on genomic screening and studies of COCs cultured in vitro , we showed that intermedin (IMD)/adrenomedullin 2 (ADM2) is a novel oocyte-derived ligand important for the regulation of cell interactions in COCs that functions, in part, by suppressing cumulus cell apoptosis. (pubmedcentralcanada.ca)
  • We previously observed protection against VILI by Adrenomedullin (AM). Here we analyzed impact VILI on lung injury, pulmonary and systemic inflammation, bacterial burden and end-organ injury in established pneumonia. (ersjournals.com)
  • Adrenomedullin exhibited endothelial barrier-stabilising properties in vitro and in vivo. (bmj.com)
  • Adrenomedullin (AM), an endogenous 52 amino acid peptide belonging to the calcitonin gene-related peptide family, plays a crucial role in endothelial barrier integrity, which is underlined by the observation that AM deficiency in mice is lethal due to midgestation death as a result of hydrops fetalis. (bmj.com)
  • OBJECTIVE To elucidate whether prognosis after acute myocardial infarction can be predicted by measuring plasma adrenomedullin, a novel vasorelaxant peptide. (bmj.com)
  • 9 10 Thus it is still unclear whether plasma adrenomedullin measured in the acute phase after myocardial infarction is a good indicator of mortality. (bmj.com)
  • Results Adrenomedullin dramatically reduced lung permeability in VILI in mice, leading to improved oxygenation. (bmj.com)
  • Moreover, adrenomedullin protected against VILI even when treatment was initiated 2 h after the beginning of mechanical ventilation in a 6 h VILI mouse model. (bmj.com)
  • Conclusion Adjuvant treatment with adrenomedullin may be a promising new pharmacological approach to attenuate VILI. (bmj.com)
  • Hennigsdorf/Berlin - Diagnostics company sphingotec GmbH reports novel applications of bio-ADM® (bio-active adrenomedullin), the very first biomarker capable to diagnose the onset of septic shock, allowing physicians earliest life-saving therapeutic interventions in sepsis critical care. (eurekalert.org)
  • The aim of the present study was to investigate the pathophysiological significance of adrenomedullin in hypoxaemia caused by congenital cyanotic heart disease. (portlandpress.com)
  • By RNA-blot analysis, human adrenomedullin mRNA was found to be expressed in all tissues, and most highly expressed in the placenta, fat cells, lung, pancreatic islets, smooth muscle, and skin. (wikipedia.org)
  • Adrenomedullin (ADM) is a mitogen for human retinal pigment epithelial cells (hRPE) and stimulates cAMP in rat2 fibroblasts. (arvojournals.org)
  • These data suggest that adrenomedullin is a new hormone participating in blood pressure control. (nih.gov)
  • Intrinsically increased adrenomedullin levels may function as a compensatory mechanism for hypoxaemia in congenital cyanotic heart disease. (portlandpress.com)
  • Our findings indicate that circulating adrenomedullin is increased in insulinoma and that this increase is related to the neoplastic phenotype. (sigmaaldrich.com)