Logical Observation Identifiers Names and Codes: A vocabulary database of universal identifiers for laboratory and clinical test results. Its purpose is to facilitate the exchange and pooling of results for clinical care, outcomes management, and research. It is produced by the Regenstrief Institute. (LOINC and RELMA [Internet]. Indianapolis: The Regenstrief Institute; c1995-2001 [cited 2002 Apr 2]. Available from http://www.regenstrief.org/loinc)Clinical Laboratory Information Systems: Information systems, usually computer-assisted, designed to store, manipulate, and retrieve information for planning, organizing, directing, and controlling administrative and clinical activities associated with the provision and utilization of clinical laboratory services.Copyright: It is a form of protection provided by law. In the United States this protection is granted to authors of original works of authorship, including literary, dramatic, musical, artistic, and certain other intellectual works. This protection is available to both published and unpublished works. (from Circular of the United States Copyright Office, 6/30/2008)Adrenocorticotropic Hormone: An anterior pituitary hormone that stimulates the ADRENAL CORTEX and its production of CORTICOSTEROIDS. ACTH is a 39-amino acid polypeptide of which the N-terminal 24-amino acid segment is identical in all species and contains the adrenocorticotrophic activity. Upon further tissue-specific processing, ACTH can yield ALPHA-MSH and corticotrophin-like intermediate lobe peptide (CLIP).Terminology as Topic: The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.Vocabulary, Controlled: A specified list of terms with a fixed and unalterable meaning, and from which a selection is made when CATALOGING; ABSTRACTING AND INDEXING; or searching BOOKS; JOURNALS AS TOPIC; and other documents. The control is intended to avoid the scattering of related subjects under different headings (SUBJECT HEADINGS). The list may be altered or extended only by the publisher or issuing agency. (From Harrod's Librarians' Glossary, 7th ed, p163)Software: Sequential operating programs and data which instruct the functioning of a digital computer.Clinical Audit: A detailed review and evaluation of selected clinical records by qualified professional personnel to improve the quality of patient care and outcomes. The clinical audit was formally introduced in 1993 into the United Kingdom's National Health Service.IndianaClinical Coding: Process of substituting a symbol or code for a term such as a diagnosis or procedure. (from Slee's Health Care Terms, 3d ed.)Dictionaries, MedicalDictionaries as Topic: Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.Hydrocortisone: The main glucocorticoid secreted by the ADRENAL CORTEX. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions.Adrenal Glands: A pair of glands located at the cranial pole of each of the two KIDNEYS. Each adrenal gland is composed of two distinct endocrine tissues with separate embryonic origins, the ADRENAL CORTEX producing STEROIDS and the ADRENAL MEDULLA producing NEUROTRANSMITTERS.Pituitary-Adrenal System: The interactions between the anterior pituitary and adrenal glands, in which corticotropin (ACTH) stimulates the adrenal cortex and adrenal cortical hormones suppress the production of corticotropin by the anterior pituitary.Hormones: Chemical substances having a specific regulatory effect on the activity of a certain organ or organs. The term was originally applied to substances secreted by various ENDOCRINE GLANDS and transported in the bloodstream to the target organs. It is sometimes extended to include those substances that are not produced by the endocrine glands but that have similar effects.Hypothalamo-Hypophyseal System: A collection of NEURONS, tracts of NERVE FIBERS, endocrine tissue, and blood vessels in the HYPOTHALAMUS and the PITUITARY GLAND. This hypothalamo-hypophyseal portal circulation provides the mechanism for hypothalamic neuroendocrine (HYPOTHALAMIC HORMONES) regulation of pituitary function and the release of various PITUITARY HORMONES into the systemic circulation to maintain HOMEOSTASIS.Pituitary Gland, Anterior: The anterior glandular lobe of the pituitary gland, also known as the adenohypophysis. It secretes the ADENOHYPOPHYSEAL HORMONES that regulate vital functions such as GROWTH; METABOLISM; and REPRODUCTION.Corticotropin-Releasing Hormone: A peptide of about 41 amino acids that stimulates the release of ADRENOCORTICOTROPIC HORMONE. CRH is synthesized by neurons in the PARAVENTRICULAR NUCLEUS of the HYPOTHALAMUS. After being released into the pituitary portal circulation, CRH stimulates the release of ACTH from the PITUITARY GLAND. CRH can also be synthesized in other tissues, such as PLACENTA; ADRENAL MEDULLA; and TESTIS.Pituitary Neoplasms: Neoplasms which arise from or metastasize to the PITUITARY GLAND. The majority of pituitary neoplasms are adenomas, which are divided into non-secreting and secreting forms. Hormone producing forms are further classified by the type of hormone they secrete. Pituitary adenomas may also be characterized by their staining properties (see ADENOMA, BASOPHIL; ADENOMA, ACIDOPHIL; and ADENOMA, CHROMOPHOBE). Pituitary tumors may compress adjacent structures, including the HYPOTHALAMUS, several CRANIAL NERVES, and the OPTIC CHIASM. Chiasmal compression may result in bitemporal HEMIANOPSIA.Hodgkin Disease: A malignant disease characterized by progressive enlargement of the lymph nodes, spleen, and general lymphoid tissue. In the classical variant, giant usually multinucleate Hodgkin's and REED-STERNBERG CELLS are present; in the nodular lymphocyte predominant variant, lymphocytic and histiocytic cells are seen.Neurosurgery: A surgical specialty concerned with the treatment of diseases and disorders of the brain, spinal cord, and peripheral and sympathetic nervous system.Diaphragm: The musculofibrous partition that separates the THORACIC CAVITY from the ABDOMINAL CAVITY. Contraction of the diaphragm increases the volume of the thoracic cavity aiding INHALATION.Adenoma: A benign epithelial tumor with a glandular organization.Growth Hormone-Secreting Pituitary Adenoma: A pituitary tumor that secretes GROWTH HORMONE. In humans, excess HUMAN GROWTH HORMONE leads to ACROMEGALY.Acromegaly: A condition caused by prolonged exposure to excessive HUMAN GROWTH HORMONE in adults. It is characterized by bony enlargement of the FACE; lower jaw (PROGNATHISM); hands; FEET; HEAD; and THORAX. The most common etiology is a GROWTH HORMONE-SECRETING PITUITARY ADENOMA. (From Joynt, Clinical Neurology, 1992, Ch36, pp79-80)Neurosurgical Procedures: Surgery performed on the nervous system or its parts.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.Sphenoid Bone: An irregular unpaired bone situated at the SKULL BASE and wedged between the frontal, temporal, and occipital bones (FRONTAL BONE; TEMPORAL BONE; OCCIPITAL BONE). Sphenoid bone consists of a median body and three pairs of processes resembling a bat with spread wings. The body is hollowed out in its inferior to form two large cavities (SPHENOID SINUS).ArchivesPhysician-Patient Relations: The interactions between physician and patient.Pituitary Gland: A small, unpaired gland situated in the SELLA TURCICA. It is connected to the HYPOTHALAMUS by a short stalk which is called the INFUNDIBULUM.Physicians: Individuals licensed to practice medicine.Empathy: An individual's objective and insightful awareness of the feelings and behavior of another person. It should be distinguished from sympathy, which is usually nonobjective and noncritical. It includes caring, which is the demonstration of an awareness of and a concern for the good of others. (From Bioethics Thesaurus, 1992)Growth Hormone: A polypeptide that is secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Growth hormone, also known as somatotropin, stimulates mitosis, cell differentiation and cell growth. Species-specific growth hormones have been synthesized.Health Personnel: Men and women working in the provision of health services, whether as individual practitioners or employees of health institutions and programs, whether or not professionally trained, and whether or not subject to public regulation. (From A Discursive Dictionary of Health Care, 1976)Prolactin: A lactogenic hormone secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). It is a polypeptide of approximately 23 kD. Besides its major action on lactation, in some species prolactin exerts effects on reproduction, maternal behavior, fat metabolism, immunomodulation and osmoregulation. Prolactin receptors are present in the mammary gland, hypothalamus, liver, ovary, testis, and prostate.Receptors, Prolactin: Labile proteins on or in prolactin-sensitive cells that bind prolactin initiating the cells' physiological response to that hormone. Mammary casein synthesis is one of the responses. The receptors are also found in placenta, liver, testes, kidneys, ovaries, and other organs and bind and respond to certain other hormones and their analogs and antagonists. This receptor is related to the growth hormone receptor.Journal Impact Factor: A quantitative measure of the frequency on average with which articles in a journal have been cited in a given period of time.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Carbohydrate Epimerases: Enzymes that catalyze the epimerization of chiral centers within carbohydrates or their derivatives. EC 5.1.3.
(1/3421) Cortisol in fetal fluids and the fetal adrenal at parturition in the tammar wallaby (Macropus eugenii).

Glucocorticoid hormones may play a critical role in initiating parturition in tammar wallabies. In this study, we investigated the concentration of cortisol in fetal fluids and cortisol production by fetal adrenals over the last 3 days of the 26-day pregnancy and within 24 h postpartum. The fetal adrenals almost doubled in size between Days 24 and 26 of pregnancy, and their cortisol content increased over 10-fold during this period, from 10 pg to over 100 pg per adrenal pair. After birth, neonatal adrenals continued to grow, but cortisol content fell dramatically to 20 pg. The prepartum increase in adrenal cortisol was reflected by a substantial rise in cortisol concentrations in yolk sac fluid, allantoic fluid, and fetal blood, which were below 10 ng/ml on Day 24 and rose to over 40 ng/ml by Day 26. Cortisol concentrations in neonatal blood decreased postpartum, mirroring decreased cortisol content in neonatal adrenals. Cortisol production by the fetal adrenal was stimulated in vitro by ACTH and prostaglandin E2, suggesting that the in vivo increase may be stimulated by release of ACTH from the fetal hypothalamic-pituitary axis and prostaglandin E2 from the placenta. These results indicate that increasing cortisol production by the fetal adrenal is a characteristic of late pregnancy in the tammar wallaby and support the suggestion that fetal cortisol may trigger the initiation of parturition in this marsupial species.  (+info)

(2/3421) Delay of preterm delivery in sheep by omega-3 long-chain polyunsaturates.

A positive correlation has been shown between dietary intake of long-chain omega-3 fatty acids in late pregnancy and gestation length in pregnant women and experimental animals. To determine whether omega-3 fatty acids have an effect on preterm labor in sheep, a fish oil concentrate emulsion was continuously infused to six pregnant ewes from 124 days gestational age. At 125 days, betamethasone was administered to the fetus to produce preterm labor. Both the onset of labor and the time of delivery were delayed by the fish oil emulsion. Two of the omega-3-infused ewes reverted from contractions to nonlabor, an effect never previously observed for experimental glucocorticoid-induced preterm labor in sheep. Maternal plasma estradiol and maternal and fetal prostaglandin E2 rose in control ewes but not in those infused with omega-3 fatty acid. The ability of omega-3 fatty acids to delay premature delivery in sheep indicates their possible use as tocolytics in humans. Premature labor is the major cause of neonatal death and long-term disability, and these studies present information that may lead to a novel therapeutic regimen for the prevention of preterm delivery in human pregnancy.  (+info)

(3/3421) On the meaning of low-dose ACTH(1-24) tests to assess functionality of the hypothalamic-pituitary-adrenal axis.

To analyse further the ACTH(1-24) low-dose test, which is of clinical interest, we have examined the dose-response relationship between plasma ACTH(1-24) and cortisol concentrations after i.v. administration of increasing doses (1, 5 or 250 microg) of ACTH(1-24) as a bolus. In addition, we have measured plasma ACTH(1-39) and cortisol levels after an insulin tolerance test (ITT). Although there was a dose response relationship between plasma ACTH(1-24) immunoreactivity and the dose injected, cortisol peaks were comparable, but lower than those reached after an ITT. Under these experimental conditions, an increase in plasma ACTH as low as 13 pmol/l (i.e. the increase obtained with the 1 microg dose) induced a near maximal cortisol response. Following injection of 1 microg ACTH(1-24), peak ACTH values were short lasting, similar to physiological daily bursts. After injection of 5 microg ACTH(1-24), plasma ACTH concentrations were higher than those reached during an ITT, but clearly shorter lasting. Injection of 250 microg ACTH(1-24) induced strikingly supraphysiological levels of plasma ACTH. We conclude that neither regular nor low-dose ACTH tests can fully reproduce the ITT. Our observations strongly suggest that the low-dose ACTH(1-24) test (1 microg) can be useful to estimate the adrenal sensitivity under basal, physiological conditions.  (+info)

(4/3421) The treatment of insulin resistance does not improve adrenal cytochrome P450c17alpha enzyme dysregulation in polycystic ovary syndrome.

OBJECTIVE: To determine whether metformin. when given to non-diabetic women with polycystic ovary syndrome (PCOS), results in a reduction of insulin resistance and hyperinsulinemia while body weight is maintained. Also we aimed to see whether the reduction in insulin levels attenuates the activity of adrenal P450c17alpha enzyme in patients with PCOS. DESIGN: We investigated the 17-hydroxyprogesterone (17-OHP) and androstenedione responses to ACTH, insulin responses to an oral glucose tolerance test (OGTT) and glucose disposal rate in an insulin tolerance test before and after metformin therapy (500 mg, orally, twice daily, for 12 weeks). METHODS: The presence of hyperinsulinemia in 15 women with PCOS was demonstrated by an OGTT and results were compared with those of 10 healthy women. Insulin sensitivity was measured by the rate of endogenous glucose disposal after i.v. bolus injection of insulin. 17-OHP and androstenedione responses to ACTH were measured in all the women with PCOS and the normal women. RESULTS: Women with PCOS were hyperinsulinemic (102.0+/-13.0 (S.E.M.) VS 46.2+/-4.4 pmol/l) and hyperandrogenemic (free testosterone 15.3+/-1.7 vs 7.9+/-0.6 nmol/l; androstenedione 11.8+/-0.8 vs 8.2+/-0.6 nmol/l) and more hirsute (modified Ferriman-Gallwey score, 17.7+/-1.6 vs 3.0+/-0.3) than healthy women. In addition, women with PCOS had higher 17-OHP and androstenedione responses to ACTH when compared with healthy women. Metformin therapy resulted in some improvement in insulin sensitivity and reduced the basal and post-glucose load insulin levels. But 17-OHP and androstenedione responses to ACTH were unaltered in response to metformin. CONCLUSIONS: PCOS is characterized by hyperactivity of the adrenal P450c17alpha enzyme and insulin resistance. It seems that there is no direct relationship between insulin resistance and adrenal P450c17alpha enzyme dysregulation.  (+info)

(5/3421) Primary hypoadrenocorticism in a dog receiving glucocorticoid supplementation.

A 5-year-old, spayed, female husky-Labrador retriever cross was diagnosed with primary hypoadrenocorticism, an uncommon endocrine disorder caused by a deficiency of glucocorticoid and mineralocorticoid hormones. Subtle clinical signs and previous treatment with exogenous glucocorticoid drugs required an adrenocorticotropic hormone stimulation test to confirm the diagnosis.  (+info)

(6/3421) Central administration of rat IL-6 induces HPA activation and fever but not sickness behavior in rats.

Interleukin (IL)-6 has been proposed to mediate several sickness responses, including brain-mediated neuroendocrine, temperature, and behavioral changes. However, the exact mechanisms and sites of action of IL-6 are still poorly understood. In the present study, we describe the effects of central administration of species-homologous recombinant rat IL-6 (rrIL-6) on the induction of hypothalamic-pituitary-adrenal (HPA) activity, fever, social investigatory behavior, and immobility. After intracerebroventricular administration of rrIL-6 (50 or 100 ng/rat), rats demonstrated HPA and febrile responses. In contrast, rrIL-6 alone did not induce changes in social investigatory and locomotor behavior at doses of up to 400 ng/rat. Coadministration of rrIL-6 (100 ng/rat) and rrIL-1beta (40 ng/rat), which alone did not affect the behavioral responses, reduced social investigatory behavior and increased the duration of immobility. Compared with rhIL-6, intracerebroventricular administration of rrIL-6 (100 ng/rat) induced higher HPA responses and early-phase febrile responses. This is consistent with a higher potency of rrIL-6, compared with rhIL-6, in the murine B9 bioassay. We conclude that species-homologous rrIL-6 alone can act in the brain to induce HPA and febrile responses, whereas it only reduces social investigatory behavior and locomotor activity in the presence of IL-1beta.  (+info)

(7/3421) Suppression of the secretion of luteinizing hormone due to isolation/restraint stress in gonadectomised rams and ewes is influenced by sex steroids.

In this study we used an isolation/restraint stress to test the hypothesis that stress will affect the secretion of LH differently in gonadectomised rams and ewes treated with different combinations of sex steroids. Romney Marsh sheep were gonadectomised two weeks prior to these experiments. In the first experiment male and female sheep were treated with vehicle or different sex steroids for 7 days prior to the application of the isolation/restraint stress. Male sheep received either i.m. oil (control rams) or 6 mg testosterone propionate injections every 12 h. Female sheep were given empty s.c. implants (control ewes), or 2x1 cm s.c. implants containing oestradiol, or an intravaginal controlled internal drug release device containing 0.3 g progesterone, or the combination of oestradiol and progesterone. There were four animals in each group. On the day of application of the isolation/restraint stress, blood samples were collected every 10 min for 16 h for the subsequent measurement of plasma LH and cortisol concentrations. After 8 h the stress was applied for 4 h. Two weeks later, blood samples were collected for a further 16 h from the control rams and ewes, but on this day no stress was imposed. In the second experiment, separate control gonadectomised rams and ewes (n=4/group) were studied for 7 h on 3 consecutive days, when separate treatments were applied. On day 1, the animals received no treatment; on day 2, isolation/restraint stress was applied after 3 h; and on day 3, an i. v. injection of 2 microg/kg ACTH1-24 was given after 3 h. On each day, blood samples were collected every 10 min and the LH response to the i.v. injection of 500 ng GnRH administered after 5 h of sampling was measured. In Experiment 1, the secretion of LH was suppressed during isolation/restraint in all groups but the parameters of LH secretion (LH pulse frequency and amplitude) that were affected varied between groups. In control rams, LH pulse amplitude, and not frequency, was decreased during isolation/restraint whereas in rams treated with testosterone propionate the stressor reduced pulse frequency and not amplitude. In control ewes, isolation/restraint decreased LH pulse frequency but not amplitude. Isolation/restraint reduced both LH pulse frequency and amplitude in ewes treated with oestradiol, LH pulse frequency in ewes treated with progesterone and only LH pulse amplitude in ewes treated with both oestradiol and progesterone. There was no change in LH secretion during the day of no stress. Plasma concentrations of cortisol were higher during isolation/restraint than on the day of no stress. On the day of isolation/restraint maximal concentrations of cortisol were observed during the application of the stressor but there were no differences between groups in the magnitude of this response. In Experiment 2, isolation/restraint reduced the LH response to GnRH in rams but not ewes and ACTH reduced the LH response to GnRH both in rams and ewes. Our results show that the mechanism(s) by which isolation/restraint stress suppresses LH secretion in sheep is influenced by sex steroids. The predominance of particular sex steroids in the circulation may affect the extent to which stress inhibits the secretion of GnRH from the hypothalamus and/or the responsiveness of the pituitary gland to the actions of GnRH. There are also differences between the sexes in the effects of stress on LH secretion that are independent of the sex steroids.  (+info)

(8/3421) Tests of adrenal insufficiency.

AIM: In suspected adrenal insufficiency, the ideal test for assessing the hypothalamo-pituitary-adrenal axis is controversial. Therefore, three tests were compared in patients presenting with symptoms suggestive of adrenal insufficiency. METHOD: Responses to the standard short Synacthen test (SSST), the low dose Synacthen test (LDST), and the 08:00 hour serum cortisol concentration were measured in 32 patients. A normal response to the synacthen test was defined as a peak serum cortisol of >/= 500 nmol/l and/or incremental concentration of >/= 200 nmol/l. The sensitivity and specificity of the 08:00 hour serum cortisol concentration compared with other tests was calculated. RESULTS: Three patients had neither an adequate peak nor increment after the SSST and LDST. All had a serum 08:00 hour cortisol concentration of < 200 nmol/l. Eight patients had abnormal responses by both criteria to the LDST but had normal responses to the SSST. Three reported amelioration of their symptoms on hydrocortisone replacement. Twenty one patients had a normal response to both tests (of these, 14 achieved adequate peak and increment after both tests and seven did not have an adequate peak after the LDST but had a normal increment). The lowest 08:00 hour serum cortisol concentration above which patients achieved normal responses to both the LDST and SSST was 500 nmol/l. At this cut off value (compared with the LDST), the serum 08:00 hour cortisol concentration had a sensitivity of 100% but specificity was only 33%. CONCLUSION: The LDST revealed mild degrees of adrenal insufficiency not detected by the SSST. The value of a single 08:00 hour serum cortisol concentration is limited.  (+info)

*  Pituitary adenoma
... adrenocorticotropic hormone (ACTH), follicle-stimulating hormone (FSH), luteinizing hormone (LH), growth hormone (GH), and ... luteinizing hormone; follicle stimulating hormone; and adrenocorticotropic hormone. Pituitary apoplexy is a condition that ... For example, insufficient adrenocorticotropic hormone means that the adrenal glands will not produce sufficient cortisol, ... CD results when a pituitary adenoma causes excessive secretion of adrenocorticotropic hormone (ACTH) that stimulates the ...
*  Adrenocorticotropic hormone
... (ACTH, also adrenocorticotropin, corticotropin) is a polypeptide tropic hormone produced and ... PMID 20148687 "Adrenocorticotropic Hormone (ACTH)". "Pro-opiomelocortin precursor". Retrieved April 8, 2013. Yalow RS, Glick SM ... doi:10.1016/S0140-6736(00)44463-6. CS1 maint: Uses authors parameter (link) Adrenocorticotropic Hormone at the US National ... "cDNA cloning and sequence analysis of the bovine adrenocorticotropic hormone (ACTH) receptor". Biochimica et Biophysica Acta. ...
*  Adrenocorticotropic hormone (medication)
Adrenocorticotropic hormone is used as a medication and as diagnostic agent in the ACTH stimulation test. The form that is ... Adrenocorticotropic Hormone at the US National Library of Medicine Medical Subject Headings (MeSH) Cosyntropin at the US ... "Treatment of nephrotic syndrome with adrenocorticotropic hormone (ACTH) gel". Drug Design, Development and Therapy. 5: 147-53. ... Both versions of the hormone are also used to perform the ACTH stimulation test to diagnose hypoadrenocorticism in dogs and ...
*  Adrenocorticotropic hormone deficiency
... (ACTH deficiency) is a result of a decreased or absent production of adrenocorticotropic ... hormone (ACTH) by the pituitary gland. It can be associated with TBX19. Symptoms include weakness, hypoglycemia, weight loss ...
*  Mifepristone
ISBN 0-07-142280-3. Schimmer, Bernard P.; Parker, Keith L. (2006). "Adrenocorticotropic Hormone; Adrenocortical Steroids and ... with a correlative assessment of androgen-related hormones". BJU Int. 101 (9): 1084-9. doi:10.1111/j.1464-410X.2008.07509.x. ... is a synthetic estrane steroid and a derivative of steroid hormones like progesterone, cortisol, and testosterone. It has ... Their Synthetic Analogs; Inhibitors of the Synthesis and Actions of Adrenocortical Hormones". In in Brunton, Laurence L.; Lazo ...
*  List of OMIM disorder codes
DAX1 Adrenocorticotropic hormone deficiency; 201400; TBS19 Adrenoleukodystrophy; 300100; ABCD1 Adrenoleukodystrophy, neonatal; ... SECISBP2 Thyroid hormone resistance; 188570; THRB Thyroid hormone resistance, autosomal recessive; 274300; THRB Thyroid hormone ... HESX1 Growth hormone deficiency, isolated, type IA; 262400; GH1 Growth hormone deficiency, isolated, type IB; 612781; GH1 ... GHRHR Growth hormone deficiency, isolated, type II; 173100; GH1 Growth hormone insensitivity with immunodeficiency; 245590; ...
*  ACTH receptor
The adrenocorticotropic hormone receptor or ACTH receptor also known as the melanocortin receptor 2 or MC2 receptor is a type ... "ACTH - Clinical: Adrenocorticotropic Hormone (ACTH), Plasma". www.mayomedicallaboratories.com. Retrieved 2016-10-25. Gallo- ... adrenocorticotropic hormone) and melanocortin-3 receptors to chromosomes 18p11.2 and 20q13.2-q13.3 by fluorescence in situ ... "cDNA cloning and sequence analysis of the bovine adrenocorticotropic hormone (ACTH) receptor". Biochimica et Biophysica Acta. ...
*  ACTH stimulation test
"Mosby's Diagnostic and Laboratory Test Reference 2nd ed.: Adrenocorticotropic hormone stimulation test": 17-18. Ashley B. ... Progesterone - precursor to cortisol and aldosterone Luteinizing hormone - a pituitary hormone that stimulates sex hormone ... "GENERIC NAME: COSYNTROPIN - INJECTABLE (koe-sin-TROW-pin)". Hormones (Athens). 2012 Oct-Dec;11(4):428-35. Is the 250 μg ACTH ... assess the functioning of the adrenal glands stress response by measuring the adrenal response to adrenocorticotropic hormone ( ...
*  Carbohydrate metabolism
Glucagon, adrenocorticotropic hormone, and ATP encourage gluconeogenesis. Gluconeogenesis is inhibited by AMP, ADP, and insulin ... Hormones released from the pancreas regulate the overall metabolism of glucose. Insulin and glucagon are the primary hormones ...
*  Psychoneuroimmunology
CRH Regulates secretion of Adrenocorticotropic hormone (ACTH). CRH is widely distributed in the brain and periphery CRH also ... HPA axis activity and cytokines are intrinsically intertwined: inflammatory cytokines stimulate adrenocorticotropic hormone ( ... Anti-inflammatory hormones that enhance the organism's response to a stressor. Prevent the overreaction of the body's own ... Release of corticotropin-releasing hormone (CRH) from the hypothalamus is influenced by stress. CRH is a major regulator of the ...
*  Steroidogenic acute regulatory protein
Krueger RJ, Orme-Johnson NR (August 1983). "Acute adrenocorticotropic hormone stimulation of adrenal corticosteroidogenesis". J ... Hormones that stimulate its production depend on the cell type and include luteinizing hormone (LH), ACTH and angiotensin II. ... Srivastava VK, Vijayan E, Hiney JK, Dees WL (October 2005). "Effect of ethanol on follicle stimulating hormone-induced ... which is the rate-limiting step in the production of steroid hormones. It is primarily present in steroid-producing cells, ...
*  Posterior pituitary
It comprises corticotropin-releasing factor (CRF), released by the hypothalamus; adrenocorticotropic hormone (ACTH), released ... the anterior pituitary hormone thyroid-stimulating hormone (TSH); and the thyroid hormones T3 and T4. •The hypothalamic- ... Two hormones are classically considered as being related to the posterior pituitary: oxytocin and vasopressin. These hormones ... the anterior pituitary luteinizing hormone (LH) and follicle-stimulating hormone (FSH), and the gonadal steroids. Hatton, GI ( ...
*  Neuroendocrine cell
It comprises corticotropin-releasing factor (CRF), released by the hypothalamus; adrenocorticotropic hormone (ACTH), released ... the anterior pituitary hormone thyroid-stimulating hormone (TSH); and the thyroid hormones T3 and T4. •The hypothalamic- ... the anterior pituitary luteinizing hormone (LH) and follicle-stimulating hormone (FSH), and the gonadal steroids. Chong S, Lee ... control the secretion of pituitary hormones, while others (the hormones oxytocin and vasopressin) are released directly into ...
*  Stress in early childhood
At this location, adrenocorticotropic hormone (ACTH) is released. ACTH binds to the receptors in the adrenal glands, which are ... Because cortisol hormone enters the cell's nucleus, the effects of change take longer to occur, and last for a longer period of ... The hormone then reacts with receptors inside of the cell. The activated receptors reach the nucleus of the cells and regulate ... The changes include an increase in heart rate and a change in hormone cortisol levels. The first day of school, a family ...
*  Reference ranges for blood tests
Adrenocorticotropic hormone, on the other hand, with a molar mass of 4540, is 0.7 decades to the right in the mass image. ... This molar mass was taken from: PROOPIOMELANOCORTIN; NCBI --> POMC Retrieved on September 28, 2009 "Adrenocorticotropic Hormone ... Häggström, Mikael (2014). "Reference ranges for estradiol, progesterone, luteinizing hormone and follicle-stimulating hormone ... Hormones predominate at the left part of the scale, shown with a red at ng/L or pmol/L, being in very low concentration. There ...
*  Effects of stress on memory
The anterior pituitary in turn releases adrenocorticotropic hormone (ACTH). ACTH induces the release of corticosteriods and ... Stress hormones influence the processes carried out in the hippocampus and amygdala which are also associated with emotional ... These stress hormones are also hindering the hippocampus from receiving enough energy by diverting glucose levels to ... The varying effects of stress on performance or stress hormones are often compared to or known as "inverted-u" which induce ...
*  Tuberous sclerosis
Adrenocorticotropic hormone was approved in 2010 to treat infantile spasms. Everolimus was approved for treatment of TSC- ...
*  Italian crested newt
This hormone is regulated by another major hormone - adrenocorticotropic hormone (ACTH). Arginine vasotocin not only increases ... Arginine, vasotocin, and adrenocorticotropic are hormones secreted by the adrenal glands and are a key component in a newt's ... Generally these hormones are secreted from two types of chromaffin cells, but in T. carnifex they are only secreted from one ... An increase of this hormone results in the decreased permeability of the skin as well as a reduction of active sodium uptake, ...
*  Osteoblast
Two of these are adrenocorticotropic hormone (ACTH) and follicle stimulating hormone. The physiological role for responses to ... A particularly important bone-targeted hormonal regulator is parathyroid hormone (PTH). Parathyroid hormone is a protein made ... The skeleton is also modified for reproduction and in response to nutritional and other hormone stresses; it responds to ... Nicks KM, Fowler TW, Gaddy D. (2010). "Reproductive hormones and bone." Curr Osteoporos Rep. 8: 60-7. doi: 10.1007/s11914-010- ...
*  Corticotropin-releasing factor family
Urocortin acts in vitro to stimulate the secretion of adrenocorticotropic hormone. Urotensin is found in the teleost caudal ... The paraventricular nucleus transports CRH to the anterior pituitary, stimulating adrenocorticotropic hormone (ACTH) release ... Corticotropin-releasing hormone (CRH) is a releasing hormone found mainly in the paraventricular nucleus of the mammalian ... This family includes corticotropin-releasing hormone, urotensin-I, urocortin, and sauvagine. The family can be grouped into 2 ...
*  Influenza
p. 7 Jefferies WM, Turner JC, Lobo M, Gwaltney JM (1998). "Low plasma levels of adrenocorticotropic hormone in patients with ...
*  Nelson's syndrome
During the disorder the patient develops macroadenomas that secrete adrenocorticotropic hormone (ACTH). The severity of the ... disease is dependent upon the effect of ACTH release on the skin, pituitary hormone loss, and the effect the tumor has on the ...
*  Israel Hanukoglu
Raikhinstein M, Zohar M, Hanukoglu I (Feb 1994). "cDNA cloning and sequence analysis of the bovine adrenocorticotropic hormone ... Hanukoglu I (Dec 1992). "Steroidogenic enzymes: structure, function, and role in regulation of steroid hormone biosynthesis". ... in regulating steroid hormone synthesis in the adrenal cortex, regulation of adrenal steroidogenic capacity in disease states, ... Israel isolated the mitochondrial enzymes that catalyze the first step in the synthesis of steroid hormones in all ...
*  Tropic hormone
... stimulates the thyroid gland to make and release thyroid hormone. Adrenocorticotropic hormone (ACTH or corticotropin) - ... Tropic hormones are hormones that have other endocrine glands as their target. Most tropic hormones are produced and secreted ... Tropic hormones are contrasted with non-tropic hormones, which directly stimulate target cells. Tropic hormones from the ... Luteinizing hormone (LH) - stimulates the release of steroid hormones in gonads-the ovary and testes. Follicle-stimulating ...
*  Beta-Endorphin
... adrenocorticotropic hormone (ACTH) and β-lipotropin. The formation of β-endorphin is then the result of cleavage of the C- ... However, POMC also gives rise to other peptide hormones, including α- and γ-melanocyte-stimulating hormone (MSH), resulting ... β-Endorphin is an endogenous opioid neuropeptide and peptide hormone that is produced in certain neurons within the central ... β-endorphin and other enkephalins are often released with ACTH to modulate hormone system functioning. Neuroregulation by β- ...
*  Cushing's syndrome
... adrenocorticotropic hormone). Excessive ACTH stimulates the adrenal cortex to produce high levels of cortisol, producing the ... Other pituitary hormone levels may need to be ascertained. Performing a physical examination to determine any visual field ... However, the total free cortisol, which is the active hormone in the body, as measured by a 24-hour urine collection for ... This is due to Melanocyte-Stimulating Hormone production as a byproduct of ACTH synthesis from Pro-opiomelanocortin (POMC). ...
*  Urotensin-II
This leads to increased plasma levels of adrenocorticotropic hormones and adrenaline. Rats and mice exhibit many stress related ... Balment RJ, Song W, Ashton N (Apr 2005). "Urotensin II: ancient hormone with new functions in vertebrate body fluid regulation ...
Adrenocorticotropic hormone - Wikipedia  Adrenocorticotropic hormone - Wikipedia
This article is about adrenocorticotropic hormone as a natural hormone. For adrenocorticotropic hormone as a medication and ... Adrenocorticotropic hormone (ACTH, also adrenocorticotropin, corticotropin) is a polypeptide tropic hormone produced by and ... Reference ranges for blood tests, showing adrenocorticotropic hormone (green at left) among the hormones with smallest ... Adrenocorticotropic+Hormone at the US National Library of Medicine Medical Subject Headings (MeSH) ...
more infohttps://en.wikipedia.org/wiki/Adrenocorticotropic_hormone
Adrenocorticotropic Hormone  Adrenocorticotropic Hormone
... Test Overview. An adrenocorticotropic hormone test measures the level of adrenocorticotropic ... An adrenocorticotropic hormone test measures the level of adrenocorticotropic hormone (ACTH) in the blood. ... ACTH is made in the pituitary gland in response to the release of another hormone, called corticotropin-releasing hormone (CRH ... In turn, the adrenal glands then make a hormone called cortisol, which helps your body manage stress. Cortisol is needed for ...
more infohttps://www.rexhealth.com/rh/health-library/document-viewer/?id=hw1613
267708: Adrenocorticotropic Hormone (ACTH), Plasma,... | LabCorp  267708: Adrenocorticotropic Hormone (ACTH), Plasma,... | LabCorp
2018 Laboratory Corporation of America® Holdings and Lexi-Comp Inc. All Rights Reserved.. CPT Statement/Profile Statement. The LOINC® codes are copyright © 1994-2018, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. Additional information regarding LOINC® codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf. ...
more infohttps://www.labcorp.com/test-menu/18856/adrenocorticotropic-hormone-acth-plasma-eight-specimens
225268: Adrenocorticotropic Hormone (ACTH), Plasma,... | LabCorp  225268: Adrenocorticotropic Hormone (ACTH), Plasma,... | LabCorp
2017 Laboratory Corporation of America® Holdings and Lexi-Comp Inc. All Rights Reserved.. CPT Statement/Profile Statement. The LOINC® codes are copyright © 1994-2017, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. Additional information regarding LOINC® codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf. ...
more infohttps://www.labcorp.com/test-menu/18836/adrenocorticotropic-hormone-acth-plasma-four-specimens
Adrenocorticotropic Hormone & ACTH Test: purpose, Procedure, Risks, Results  Adrenocorticotropic Hormone & ACTH Test: purpose, Procedure, Risks, Results
Your pituitary is a pea-sized gland at the base of the brain that produces ACTH (adrenocorticotropic hormone). This hormone, in ... Dartmouth-Hitchcock: "Adrenocorticotropic Hormone.". John's Hopkins Medicine: "Pituitary Gland," "Overactive Adrenal Glands/ ... Poor hormone production by your pituitary and adrenal glands. How Should I Prepare for the Test?. If you take steroids, you'll ... Because your hormone levels change during the day, you may have to have this done in the morning and once more later in the day ...
more infohttps://www.webmd.com/a-to-z-guides/acth-test
Adrenocorticotropic hormone (medication) - Wikipedia  Adrenocorticotropic hormone (medication) - Wikipedia
Adrenocorticotropic hormone is used as a medication and as diagnostic agent in the ACTH stimulation test. The form that is ... Adrenocorticotropic Hormone at the US National Library of Medicine Medical Subject Headings (MeSH) Cosyntropin at the US ... "Treatment of nephrotic syndrome with adrenocorticotropic hormone (ACTH) gel". Drug Design, Development and Therapy. 5: 147-53. ... Both versions of the hormone are also used to perform the ACTH stimulation test to diagnose hypoadrenocorticism in dogs and ...
more infohttps://en.wikipedia.org/wiki/Adrenocorticotropic_hormone_(medication)
Adrenocorticotropic Hormone - WellSpan Health Library  Adrenocorticotropic Hormone - WellSpan Health Library
ACTH is made in the pituitary gland in response to the release of another hormone, called corticotropin-releasing hormone (CRH ... An adrenocorticotropic hormone test measures the level of adrenocorticotropic hormone (ACTH) in the blood to check for problems ... An adrenocorticotropic hormone test measures the level of adrenocorticotropic hormone (ACTH) in the blood to check for problems ... An adrenocorticotropic hormone test measures the level of adrenocorticotropic hormone (ACTH) in the blood. ...
more infohttps://www.wellspan.org/health-library/Document.aspx?id=hw1613
Lab Test: Adrenocorticotropic Hormone | Akron Childrens Hospital  Lab Test: Adrenocorticotropic Hormone | Akron Children's Hospital
Collect on Ice. Spin down in a refrigerated centrifuge and immediately separate plasma from cells. Morning (6 a.m. -10:30 a.m.) specimen is desirable. For Outpatients, test should only be drawn in outpatient locations within a Hospital (Akron or Beeghly) Patient Preparation: 12 hours before this blood test do not take multivitamins or dietary supplements containing biotin or vitamin B7, which are commonly found in hair, skin, and nail supplements and multivitamins ...
more infohttps://www.akronchildrens.org/lab_tests/Adrenocorticotropic-Hormone.html
Adrenocorticotropic hormone - definition of adrenocorticotropic hormone by The Free Dictionary  Adrenocorticotropic hormone - definition of adrenocorticotropic hormone by The Free Dictionary
adrenocorticotropic hormone synonyms, adrenocorticotropic hormone pronunciation, adrenocorticotropic hormone translation, ... English dictionary definition of adrenocorticotropic hormone. also adrenocorticotrophic hormone n. ACTH. a hormone of the ... Related to adrenocorticotropic hormone: Adrenocorticotropic Hormone Test, follicle stimulating hormone, Adrenocorticotropic ... Examples of secreted hormones include prolactin, adrenocorticotropic hormone (ACTH), and growth hormone (GH).. Pharmacological ...
more infohttp://www.thefreedictionary.com/adrenocorticotropic+hormone
Adrenocorticotropic Hormone |omicsgroup|journal Of Autacoids  Adrenocorticotropic Hormone |omicsgroup|journal Of Autacoids
... is a polypeptide hormone produced by the anterior pituitary gland. It is an essential element of the hypothalamic-pituit.. ... Adrenocorticotropic Hormone Adrenocorticotropic hormone (ACTH) is a polypeptide hormone produced by the anterior pituitary ...
more infohttps://www.omicsonline.org/autacoids/adrenocorticotropic-hormone-journals.php
Adrenocorticotropic Hormone | Springer for Research & Development  Adrenocorticotropic Hormone | Springer for Research & Development
Corticotropin A tropic hormone released from the anterior pituitary gland resulting in the production and release of cortisol ... 2010) Adrenocorticotropic Hormone. In: Preedy V.R., Watson R.R. (eds) Handbook of Disease Burdens and Quality of Life Measures ... Public Health Stress Response Social Policy Pituitary Gland Adrenocorticotropic Hormone These keywords were added by machine ... A tropic hormone released from the anterior pituitary gland resulting in the production and release of cortisol from the ...
more infohttps://rd.springer.com/referenceworkentry/10.1007/978-0-387-78665-0_5037
CiNii 論文 - 
 		
 		
 			
 		 	
 		 		
 		 			Supradiaphragmatic ectopic adrenocorticotropic hormone-secreting adenoma
 		 		
 	...  CiNii 論文 - Supradiaphragmatic ectopic adrenocorticotropic hormone-secreting adenoma ...
Supradiaphragmatic ectopic adrenocorticotropic hormone-secreting adenoma * * Jung Shin JUNG Shin * Departments of Neurosurgery ... Ectopic Growth Hormone-Releasing Adenoma in the Cavernous Sinus : Case Report MITSUYA Koichi , NAKASU Yoko , NIOKA Hirofumi , ... Growth of hormone and prolactin secretion by a tumor of the pharyngeal pituitary WARNER BA. ...
more infohttps://ci.nii.ac.jp/naid/10008542025
Adrenocorticotropic Hormone - Lawrence Memorial Hospital  Adrenocorticotropic Hormone - Lawrence Memorial Hospital
Adrenocorticotropic Hormone. Test Overview. An adrenocorticotropic hormone test measures the level of adrenocorticotropic ... An adrenocorticotropic hormone test measures the level of adrenocorticotropic hormone (ACTH) in the blood. ... ACTH is made in the pituitary gland in response to the release of another hormone, called corticotropin-releasing hormone (CRH ... In turn, the adrenal glands then make a hormone called cortisol, which helps your body manage stress. Cortisol is needed for ...
more infohttps://www.lmh.org/wellness/health-library/document-viewer/?id=hw1613
Corticosteroids | Adrenal Gland | Adrenocorticotropic Hormone  Corticosteroids | Adrenal Gland | Adrenocorticotropic Hormone
Corticosteroids - Free download as Powerpoint Presentation (.ppt / .pptx), PDF File (.pdf), Text File (.txt) or view presentation slides online. Corticosteroids
more infohttps://pt.scribd.com/presentation/275336446/Corticosteroids
EMF-Portal | adrenocorticotropic hormone  EMF-Portal | adrenocorticotropic hormone
It is produced by the anterior pituitary gland induced by the corticotropin-releasing hormone (CRH) of the hypothalamus. ACTH ... A peptide hormone containing 39 amino acids, the first 24 of which are identical in all species and responsible for the ...
more infohttps://www.emf-portal.org/en/glossary/2045
Adrenocorticotropic Hormone Fragment 4-10 human, rat ≥97% (HPLC) | Sigma-Aldrich  Adrenocorticotropic Hormone Fragment 4-10 human, rat ≥97% (HPLC) | Sigma-Aldrich
Adrenocorticotropic Hormone Fragment 4-10 human, rat ≥97% (HPLC); CAS Number: 4037-01-8; Synonym: ACTH4-10; Linear Formula: ... Lacks adrenocorticotropic activity. Biochem/physiol Actions Adrenocorticotropic Hormone Fragment 4-10 (ACTH (4-10)) attenuates ... Adrenocorticotropic Hormone Fragment 4-10 human, rat ≥97% (HPLC) Synonym: ACTH4-10 ... Adrenocorticotropic Hormones (ACTH), Cell Biology, Cell Signaling and Neuroscience, Peptides and Proteins, Peptides for Cell ...
more infohttps://www.sigmaaldrich.com/catalog/product/sigma/A0401?lang=en®ion=US
Potassium, Corticosterone, and Adrenocorticotropic Hormone Release in vitro | Science  Potassium, Corticosterone, and Adrenocorticotropic Hormone Release in vitro | Science
Potassium, Corticosterone, and Adrenocorticotropic Hormone Release in vitro. By Jacob Kraicer, J. V. Milligan, J. L. Gosbee, R ... Potassium, Corticosterone, and Adrenocorticotropic Hormone Release in vitro. By Jacob Kraicer, J. V. Milligan, J. L. Gosbee, R ... Potassium, Corticosterone, and Adrenocorticotropic Hormone Release in vitro Message Subject. (Your Name) has forwarded a page ... Incubation of rat adenohypophyses in a high concentration of potassium increases adrenocorticotropic hormone release. This ...
more infohttps://science.sciencemag.org/content/164/3878/426
Horse ACTH (adrenocorticotropic hormone) ELISA Kit  Horse ACTH (adrenocorticotropic hormone) ELISA Kit
Due to their limited shelf life, the ImmunoTag™ ELISA kits are not typically stocked as finished goods. Please allow 2-3 weeks for delivery. Upon receipt of an order each kit is assembled and tested to ensure that it meets specifications before shipping. Minor changes may occur to the Range, Sensitivity, and Precision and is reflected in the manual supplied with the kit (online manuals are for reference only). In the event of a significant change the order would be confirmed with the customer before shipping ...
more infohttps://www.gbiosciences.com/Horse_ACTH_adrenocorticotropic_hormone_ELISA_Kit
Archives of Adrenocorticotropic hormone-producing tumors from the Brain/Pituitary Tumors Forum - MedHelp  Archives of Adrenocorticotropic hormone-producing tumors from the Brain/Pituitary Tumors Forum - MedHelp
The Archives of Adrenocorticotropic hormone-producing tumors Questions. Listed below are our archive of questions and answers ...
more infohttp://www.medhelp.org/topics/show/5117
Adrenocorticotropic Hormone (Acth) Tests | Massachusetts  Adrenocorticotropic Hormone (Acth) Tests | Massachusetts
You can use this list to find local Adrenocorticotropic Hormone (Acth) testing. ... Adrenocorticotropic Hormone (acth) testing in Massachusetts use the list of cities that we have Adrenocorticotropic Hormone ( ... List of all cities in Massachusetts with Adrenocorticotropic Hormone (acth) testing centers ... Adrenocorticotropic Hormone (Acth) Test - Massachusetts Locations By City Do you live in Massachusetts and need a ...
more infohttps://www.personalabs.com/adrenocorticotropic-hormone-
  • However, POMC also gives rise to other peptide hormones, including α- and γ-melanocyte-stimulating hormone (MSH), resulting from intracellular processing by internal enzymes known as prohormone convertases. (wikipedia.org)
  • The question is raised as to whether the marked lymphoid atrophy produced by these hormones may be related to the interference with antibody production. (rupress.org)
  • It is the common mechanism for interactions among glands, hormones, and parts of the midbrain that mediate the general adaptation syndrome (GAS). (wikipedia.org)
  • A family of related receptors mediates the actions of these hormones, the MCR, or melanocortin receptor family. (wikipedia.org)
  • The neurons send processes to a region connecting to the pituitary stalk and releasing hormones are delivered into the bloodstream. (wikipedia.org)
  • β-Endorphin is an endogenous opioid neuropeptide and peptide hormone that is produced in certain neurons within the central nervous system and peripheral nervous system. (wikipedia.org)
  • During times of stress, the body reacts by secreting stress hormones into the bloodstream. (wikipedia.org)
  • Melanotropic ligands such as a-melanocyte-stimulating hormone and adrenocorticotropic hormone act via MC1R and regulate the proportion of the photo-protective melanins eumelanin and pheomelanin, which may contribute to ultraviolet (UV) radiation-induced skin damage (1) by favoring the synthesis of eumelanin. (thefreedictionary.com)
  • The steroidogenic acute regulatory protein, commonly referred to as StAR (STARD1), is a transport protein that regulates cholesterol transfer within the mitochondria, which is the rate-limiting step in the production of steroid hormones. (wikipedia.org)
  • Follicle-stimulating hormone (FSH) - stimulates the maturation of eggs and production of sperm. (wikipedia.org)