Excess production of ADRENAL CORTEX HORMONES such as ALDOSTERONE; HYDROCORTISONE; DEHYDROEPIANDROSTERONE; and/or ANDROSTENEDIONE. Hyperadrenal syndromes include CUSHING SYNDROME; HYPERALDOSTERONISM; and VIRILISM.
A malignant neoplasm of the ADRENAL CORTEX. Adrenocortical carcinomas are unencapsulated anaplastic (ANAPLASIA) masses sometimes exceeding 20 cm or 200 g. They are more likely to be functional than nonfunctional, and produce ADRENAL CORTEX HORMONES that may result in hypercortisolism (CUSHING SYNDROME); HYPERALDOSTERONISM; and/or VIRILISM.
Tumors or cancers of the ADRENAL CORTEX.
The striated muscle groups which move the LARYNX as a whole or its parts, such as altering tension of the VOCAL CORDS, or size of the slit (RIMA GLOTTIDIS).
Difficulty and/or pain in PHONATION or speaking.
A variety of techniques used to help individuals utilize their voice for various purposes and with minimal use of muscle energy.
Pathological processes that affect voice production, usually involving VOCAL CORDS and the LARYNGEAL MUCOSA. Voice disorders can be caused by organic (anatomical), or functional (emotional or psychological) factors leading to DYSPHONIA; APHONIA; and defects in VOICE QUALITY, loudness, and pitch.
The process of producing vocal sounds by means of VOCAL CORDS vibrating in an expiratory blast of air.
A benign neoplasm of the ADRENAL CORTEX. It is characterized by a well-defined nodular lesion, usually less than 2.5 cm. Most adrenocortical adenomas are nonfunctional. The functional ones are yellow and contain LIPIDS. Depending on the cell type or cortical zone involved, they may produce ALDOSTERONE; HYDROCORTISONE; DEHYDROEPIANDROSTERONE; and/or ANDROSTENEDIONE.
The outer layer of the adrenal gland. It is derived from MESODERM and comprised of three zones (outer ZONA GLOMERULOSA, middle ZONA FASCICULATA, and inner ZONA RETICULARIS) with each producing various steroids preferentially, such as ALDOSTERONE; HYDROCORTISONE; DEHYDROEPIANDROSTERONE; and ANDROSTENEDIONE. Adrenal cortex function is regulated by pituitary ADRENOCORTICOTROPIN.
That component of SPEECH which gives the primary distinction to a given speaker's VOICE when pitch and loudness are excluded. It involves both phonatory and resonatory characteristics. Some of the descriptions of voice quality are harshness, breathiness and nasality.
FIBROUS DYSPLASIA OF BONE affecting several bones. When melanotic pigmentation (CAFE-AU-LAIT SPOTS) and multiple endocrine hyperfunction are additionally associated it is referred to as Albright syndrome.
A pair of cone-shaped elastic mucous membrane projecting from the laryngeal wall and forming a narrow slit between them. Each contains a thickened free edge (vocal ligament) extending from the THYROID CARTILAGE to the ARYTENOID CARTILAGE, and a VOCAL MUSCLE that shortens or relaxes the vocal cord to control sound production.
A pair of glands located at the cranial pole of each of the two KIDNEYS. Each adrenal gland is composed of two distinct endocrine tissues with separate embryonic origins, the ADRENAL CORTEX producing STEROIDS and the ADRENAL MEDULLA producing NEUROTRANSMITTERS.
A medical specialty concerned with the diagnosis and treatment of diseases of the internal organ systems of adults.
An anti-inflammatory 9-fluoro-glucocorticoid.
Databases devoted to knowledge about specific chemicals.
The 17-valerate derivative of BETAMETHASONE. It has substantial topical anti-inflammatory activity and relatively low systemic anti-inflammatory activity.
A group of CORTICOSTEROIDS that affect carbohydrate metabolism (GLUCONEOGENESIS, liver glycogen deposition, elevation of BLOOD SUGAR), inhibit ADRENOCORTICOTROPIC HORMONE secretion, and possess pronounced anti-inflammatory activity. They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system.
Salts and esters of the 16-carbon saturated monocarboxylic acid--palmitic acid.
The administration of substances into the eye with a hypodermic syringe.
Databases devoted to knowledge about PHARMACEUTICAL PRODUCTS.
A condition caused by prolonged exposure to excess levels of cortisol (HYDROCORTISONE) or other GLUCOCORTICOIDS from endogenous or exogenous sources. It is characterized by upper body OBESITY; OSTEOPOROSIS; HYPERTENSION; DIABETES MELLITUS; HIRSUTISM; AMENORRHEA; and excess body fluid. Endogenous Cushing syndrome or spontaneous hypercortisolism is divided into two groups, those due to an excess of ADRENOCORTICOTROPIN and those that are ACTH-independent.
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
The main glucocorticoid secreted by the ADRENAL CORTEX. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions.
A naturally occurring glucocorticoid. It has been used in replacement therapy for adrenal insufficiency and as an anti-inflammatory agent. Cortisone itself is inactive. It is converted in the liver to the active metabolite HYDROCORTISONE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p726)
A disease of the PITUITARY GLAND characterized by the excess amount of ADRENOCORTICOTROPIC HORMONE secreted. This leads to hypersecretion of cortisol (HYDROCORTISONE) by the ADRENAL GLANDS resulting in CUSHING SYNDROME.
The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.
A group of inherited disorders of the ADRENAL GLANDS, caused by enzyme defects in the synthesis of cortisol (HYDROCORTISONE) and/or ALDOSTERONE leading to accumulation of precursors for ANDROGENS. Depending on the hormone imbalance, congenital adrenal hyperplasia can be classified as salt-wasting, hypertensive, virilizing, or feminizing. Defects in STEROID 21-HYDROXYLASE; STEROID 11-BETA-HYDROXYLASE; STEROID 17-ALPHA-HYDROXYLASE; 3-beta-hydroxysteroid dehydrogenase (3-HYDROXYSTEROID DEHYDROGENASES); TESTOSTERONE 5-ALPHA-REDUCTASE; or steroidogenic acute regulatory protein; among others, underlie these disorders.
A secreted member of the TNF receptor superfamily that negatively regulates osteoclastogenesis. It is a soluble decoy receptor of RANK LIGAND that inhibits both CELL DIFFERENTIATION and function of OSTEOCLASTS by inhibiting the interaction between RANK LIGAND and RECEPTOR ACTIVATOR OF NUCLEAR FACTOR-KAPPA B.
An adrenal microsomal cytochrome P450 enzyme that catalyzes the 21-hydroxylation of steroids in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP21 gene, converts progesterones to precursors of adrenal steroid hormones (CORTICOSTERONE; HYDROCORTISONE). Defects in CYP21 cause congenital adrenal hyperplasia (ADRENAL HYPERPLASIA, CONGENITAL).
A specialized CONNECTIVE TISSUE that is the main constituent of the SKELETON. The principle cellular component of bone is comprised of OSTEOBLASTS; OSTEOCYTES; and OSTEOCLASTS, while FIBRILLAR COLLAGENS and hydroxyapatite crystals form the BONE MATRIX.
Therapeutic use of hormones to alleviate the effects of hormone deficiency.
A metabolite of PROGESTERONE with a hydroxyl group at the 17-alpha position. It serves as an intermediate in the biosynthesis of HYDROCORTISONE and GONADAL STEROID HORMONES.
A group of disorders caused by defective salt reabsorption in the ascending LOOP OF HENLE. It is characterized by severe salt-wasting, HYPOKALEMIA; HYPERCALCIURIA; metabolic ALKALOSIS, and hyper-reninemic HYPERALDOSTERONISM without HYPERTENSION. There are several subtypes including ones due to mutations in the renal specific SODIUM-POTASSIUM-CHLORIDE SYMPORTERS.
Na-K-Cl transporter in the ASCENDING LIMB OF LOOP OF HENLE. It mediates active reabsorption of sodium chloride and is inhibited by LOOP DIURETICS such as FUROSEMIDE; and BUMETANIDE. Mutations in the gene encoding SLC12A1 are associated with a BARTTER SYNDROME.
Diminished effectiveness of INSULIN in lowering blood sugar levels: requiring the use of 200 units or more of insulin per day to prevent HYPERGLYCEMIA or KETOSIS.
A cell surface receptor for INSULIN. It comprises a tetramer of two alpha and two beta subunits which are derived from cleavage of a single precursor protein. The receptor contains an intrinsic TYROSINE KINASE domain that is located within the beta subunit. Activation of the receptor by INSULIN results in numerous metabolic changes including increased uptake of GLUCOSE into the liver, muscle, and ADIPOSE TISSUE.
An inherited renal disorder characterized by defective NaCl reabsorption in the convoluted DISTAL KIDNEY TUBULE leading to HYPOKALEMIA. In contrast with BARTTER SYNDROME, Gitelman syndrome includes hypomagnesemia and normocalcemic hypocalciuria, and is caused by mutations in the thiazide-sensitive SODIUM-POTASSIUM-CHLORIDE SYMPORTERS.
A subclass of symporters that specifically transport SODIUM CHLORIDE and/or POTASSIUM CHLORIDE across cellular membranes in a tightly coupled process.
Services providing pharmaceutic and therapeutic drug information and consultation.
Financing of medical care provided to public assistance recipients.
An anterior pituitary hormone that stimulates the ADRENAL CORTEX and its production of CORTICOSTEROIDS. ACTH is a 39-amino acid polypeptide of which the N-terminal 24-amino acid segment is identical in all species and contains the adrenocorticotrophic activity. Upon further tissue-specific processing, ACTH can yield ALPHA-MSH and corticotrophin-like intermediate lobe peptide (CLIP).
A peptide of about 41 amino acids that stimulates the release of ADRENOCORTICOTROPIC HORMONE. CRH is synthesized by neurons in the PARAVENTRICULAR NUCLEUS of the HYPOTHALAMUS. After being released into the pituitary portal circulation, CRH stimulates the release of ACTH from the PITUITARY GLAND. CRH can also be synthesized in other tissues, such as PLACENTA; ADRENAL MEDULLA; and TESTIS.
Medical services for which no payment is received. Uncompensated care includes charity care and bad debts.
The state or quality of being kind, charitable, or beneficial. (from American Heritage Dictionary of the English Language, 4th ed). The ethical principle of BENEFICENCE requires producing net benefit over harm. (Bioethics Thesaurus)
Non-profit organizations concerned with various aspects of health, e.g., education, promotion, treatment, services, etc.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
Substances that dissociate into two or more ions, to some extent, in water. Solutions of electrolytes thus conduct an electric current and can be decomposed by it (ELECTROLYSIS). (Grant & Hackh's Chemical Dictionary, 5th ed)
Disturbances in the body's WATER-ELECTROLYTE BALANCE.
The balance of fluid in the BODY FLUID COMPARTMENTS; total BODY WATER; BLOOD VOLUME; EXTRACELLULAR SPACE; INTRACELLULAR SPACE, maintained by processes in the body that regulate the intake and excretion of WATER and ELECTROLYTES, particularly SODIUM and POTASSIUM.
A member of the alkali group of metals. It has the atomic symbol Na, atomic number 11, and atomic weight 23.
The addition of descriptive information about the function or structure of a molecular sequence to its MOLECULAR SEQUENCE DATA record.

Stress-level cortisol treatment impairs inhibitory control of behavior in monkeys. (1/78)

Most studies of cortisol-induced cognitive impairments have focused on hippocampal-dependent memory. This study investigates a different aspect of cognition in a randomized placebo-controlled experiment with monkeys that were treated with cortisol according to a protocol that simulates a prolonged stress response. Young adult and older adult monkeys were assigned randomly to placebo or chronic treatment with cortisol in a 2 x 2 factorial design (n = 8 monkeys per condition). Inhibitory control of behavior was assessed with a test shown previously in primates to reflect prefrontal cortical dysfunction. Failure to inhibit a specific goal-directed response was evident more often in older adults. Treatment with cortisol increased this propensity in both older and young adult monkeys. Age-related differences in response inhibition were consistent across blocks of repeated test trials, but the treatment effects were clearly expressed only after prolonged exposure to cortisol. Aspects of performance that did not require inhibition were not altered by age or treatment with cortisol, which concurs with effects on response inhibition rather than nonspecific changes in behavior. These findings lend support to related reports that cortisol-induced disruptions in prefrontal dopamine neurotransmission may contribute to deficits in response inhibition and play a role in cognitive impairments associated with endogenous hypercortisolism in humans.  (+info)

Glucocorticoid and mineralocorticoid resistance/hypersensitivity syndromes. (2/78)

Glucocorticoids and mineralocorticoids regulate diverse functions important to maintain central nervous system, cardiovascular, metabolic, and immune homeostasis. The actions of these hormones are mediated by their specific intracellular receptors: the glucocorticoid (GR) and mineralocorticoid (MR) receptors. Pathologic conditions associated with changes of tissue sensitivity to these hormones have been described. The syndrome of familial glucocorticoid resistance is characterized by hypercortisolism without Cushing's syndrome stigmata. The molecular defects of four kindreds and one sporadic case have been elucidated as inactivating mutations in the ligand-binding domain of GR. Two cases developed glucocorticoid resistance at the heterozygous state. In these patients, mutant receptors possessed transdominant negative activity upon the wild type receptor. Insensitivity to mineralocorticoids (which may also be caused by loss of function mutations of the MR gene) was found in one sporadic case and four autosomal dominant cases of Pseudohypoaldosteronism type 1. These included two frameshift mutations and a premature termination codon in exon 2, leading to gene products lacking the entire DNA- and ligand-binding domains, and a single base-pair deletion in the intron-5 splice donor site. Tissue hypersensitivity to glucocorticoids was recently hypothesized in patients with Human Immunodeficiency Virus (HIV) type-1 infection via the accessory proteins Vpr and Tat which enhance GR transactivation. Since HIV-1 long terminal repeat (LTR) and glucocorticoid-responsive promoters use the same set of coactivators, these proteins may stimulate HIV-1-LTR and glucocorticoid-inducible genes concurrently. The former may directly stimulate viral proliferation, while the latter may indirectly enhance viral propagation by suppressing the host immune system through glucocorticoid-mediated mechanisms.  (+info)

Uptake ratio of (19-1311) cholesterol by adrenal glands as observed by a scintigraphic method. (3/78)

The adrenal scintigram was performed after administration of [19-131I] cholesterol. A high/low ratio of both adrenal glands was calculated to evaluate whether there is a difference between the left and right sides in adrenal diseases. During scanning, information was stored in a 64 X 64 matrix and then punched out on a computer compatible paper tape. This paper tape was processed with a small digital computer. The areas of interest were selected over adrenal glands. The computer decided mean counts per unit area. After subtraction of background counts, a high/low ratio of adrenal gland was calculated. In five patients with Cushing's syndrome due to bilateral hyperplasia, a high/low ratio ranged from 1.0 to 2.0. In four patients with primary aldosteronism due to adenoma, a high/low ratio ranged from 1.33 to 4.0. This method may be useful to differentiate bilateral hyperplasia from unilateral adrenocortical adenoma.  (+info)

From open to laparoscopic adrenalectomy: a review of 16-year experience. (4/78)

OBJECTIVE: To review the experience with adrenal surgery which was associated with significant morbidity and notable mortality in the past, although laparoscopic approach is beginning to be accepted as the procedure of choice. METHODS: The indications and results of adrenalectomy in 104 patients (36 men, 68 women) over the past 16 years were reviewed. Any potential improvement of surgical results over time was analyzed. RESULTS: Ninety-three patients (89%) had functional problems while malignancy was present in 11 patients (11%). Anterior approach was employed in 27 patients, posterior in 56, lateral in 10, and laparoscopic in 11. One patient required conversion from laparoscopic to anterior approach. No operative mortality was seen, but the morbidity occurred in 16.7%. Complication rate decreased significantly in this study period (1981-1990 versus 1991-1996, 22% versus 5%; P = 0.02). Laparoscopic adrenalectomy was successfully performed for 59% of the patients requiring adrenalectomy recently, compared to 68% of posterior adrenalectomy in the past. CONCLUSIONS: Adrenal surgery is a safe procedure, associated with acceptable morbidity, which has decreased over time. Laparoscopic adrenalectomy is becoming the preferred approach for the majority of patients requiring adrenalectomy.  (+info)

Parathyroid hormone secretion in chronic human endogenous hypercortisolism. (5/78)

Osteoporosis is a common manifestation of Cushing's syndrome, but the mechanisms responsible for this abnormality have not been defined. With the objective of analyzing parathyroid hormone (PTH) secretion in chronic hypercortisolism (CH), we evaluated 11 healthy subjects and 8 patients with CH, 6 with Cushing's disease and 2 with adrenal adenoma. These volunteers were submitted to tests of PTH stimulation through hypocalcemia (EDTA), PTH suppression through hypercalcemia (iv and oral calcium), and evaluation of bone mineral density (BMD) by DEXA. During the test of PTH stimulation, the calcium and magnesium concentrations of the normal and CH groups were similar. Patients with CH showed an increased PTH response to the hypocalcemic stimulus compared to controls. PTH values were significantly higher in the CH group at 70 (17.5 +/- 3.5 vs 10.2 +/- 1.3 pmol/l, P = 0.04), and 120 min (26.1 +/- 5.9 vs 11.3 +/- 1.9 pmol/l, P = 0.008) of EDTA infusion. The area under the curve for PTH during EDTA infusion was also significantly higher in patients with CH than in normal subjects (1867 +/- 453 and 805 +/- 148 pmol l(-1) 2 h(-1), P = 0.02). During the test of PTH suppression, calcium, magnesium and PTH levels of the patients with hypercortisolism and controls were similar. BMD was decreased in patients with hypercortisolism in the spine (0.977 +/- 0.052 vs 1.205 +/- 0.038 g/cm2 in controls, P<0.01). In conclusion, our results show that subjects with CH present decreased bone mass mainly in trabecular bone. The use of dynamic tests permitted the detection of increased PTH secretion in response to a hypocalcemic stimulus in CH patients that may probably be involved in the occurrence of osteoporosis in this state.  (+info)

Arterial lesions in repeatedly bred spontaneously hypertensive rats. (6/78)

Repeatedly bred male and female rats of many strains develop hyperglycemia, hyperlipidemia, hypertension, and arteriosclerosis spontaneously. The intensity of their arterial disease and related metabolic derangements appear to be related to their reproductive activity. Repeatedly bred spontaneously hypertensive rats (SHR) were found to have severe hypertension, hyperglycemia, hyperlipidemia, elevated creatine phosphokinase (CPK), serum glutamic oxaloacetic and glutamic pyruvic transaminase (SGOT, SGPT), and lactic dehydrogenase (LDH), as well as high circulating corticosterone levels. Despite these atherogenic metabolic derangements and their severe hypertension, the breeder SHR did not develop the severe, generalized arteriosclerosis found in other strains of breeder rats. Instead, the arterial lesions, consisting of intimal hyalinization and fibrosis, medial hypertrophy, and occlusion of the lumen, were found only in male breeder SHR and were confined to the intratubular arteries of the testes. It is suggested that the severe hypertension, genetic influences, or differences in hypothalamic-pituitary-adrenal-gonadal function in breeder SHR may not have been conducive to the development of arteriosclerosis in this particular strain of rats.  (+info)

Osteoporosis is more prevalent in adrenal than in pituitary Cushing's syndrome. (7/78)

Osteoporosis is the most common complication of Cushing's syndrome. We retrospectively examined the prevalence and risk factors for osteoporosis in 42 female patients with Cushing's syndrome. Osteoporosis and atraumatic fractures were assessed by bone mineral density of the lumbar vertebral spine (L2-L4) using dual energy X-ray absorptiometry (DXA) and X-ray examination. The prevalence of osteoporosis and fracture were 54.8% and 21.4%, respectively. The prevalence of osteoporosis (69.6% vs. 37.8%) and atraumatic bone fracture (26.1% vs. 15.8%) were significantly higher in patients with adrenal Cushing's than in those with pituitary Cushing's. AP and lateral BMD was significantly higher in patients with pituitary origin than in those with adrenal origin. Among several variables examined by multiple logistic regression, the etiology of Cushing's syndrome (adrenal vs. pituitary origin) was a significant factor affecting the prevalence of osteoporosis. Neither age, body mass index, duration of amenorrhea, nor extent of hypercortisolism were significant factors in this analysis. Plasma DHEA-S and urinary 17-KS excretion were significantly higher in pituitary Cushing's than in adrenal Cushing's. The present study shows that the prevalence of osteoporosis in patients with Cushing's syndrome is influenced by its etiology. A factor associated with pituitary Cushing's syndrome, such as adrenal androgen, may protect these patients from glucocorticoid-induced osteoporosis.  (+info)

CARCINOMA OF LUNG WITH ADRENAL HYPERFUNCTION AND HYPERCALCEMIA TREATED BY PARATHYROIDECTOMY. (8/78)

A case of severe hypercalcemia secondary to carcinoma of the lung is described in which hypokalemic alkalosis, renal failure and pancreatitis were also present. The relative importance of the few bone metastases found at autopsy is considered, and a probable endocrine-like effect of the tumour in the development of the hypercalcemia is postulated. Treatment of the hypercalcemia included administration of corticosteroids and disodium EDTA, peritoneal dialysis and subtotal parathyroidectomy; the most effective of these was peritoneal dialysis. Subtotal parathyroidectomy failed to produce a further decrease in serum calcium values. The occurrence of hypokalemic alkalosis in the presence of increased adrenocortical function and its relationship to the carcinoma of the lung are discussed. The possibility that this neoplasm produced two factors which caused systemic effects ordinarily associated with the function of endocrine glands must be considered.  (+info)

Naturally occurring hyperadrenocorticism is a multisystemic disorder resulting from excessive production of cortisol by the adrenal cortex. Hyperadrenocorticism is caused by either excessive pituitary ACTH secretion, as in pituitary-dependent hyperadrenocorticism (PDH), or an autonomously functioning tumor of the adrenal cortex (AT). Primary adrenocortical neoplasia has been diagnosed in 10 to 20% of dogs with hyperadrenocorticism. The prevalence of adenomas and carcinomas in dogs with functioning adrenocortical tumors is approximately equal, and the right and left glands appear to be involved with equal frequency. Bilateral adrenocortical tumors resulting in hyperadrenocorticism are exceedingly rare in dogs. In a retrospective study conducted between 1983 and 1988 of 41 dogs with hyperadrenocorticism caused by adrenocortical neoplasia, 3 dogs (7%) were found to have bilateral adrenocortical neoplasia. The following is a case report of a dog that was diagnosed with hyperadrenocorticism due to ...
TY - JOUR. T1 - Use of low- and high-dose dexamethasone tests for distinguishing pituitary-dependent from adrenal tumor hyperadrenocorticism in dogs. AU - Feldman, Edward C. AU - Nelson, Richard W. AU - Feldman, Marsha S.. PY - 1996/8/15. Y1 - 1996/8/15. N2 - Objective: To evaluate low- and high-dose dexamethasone suppression tests for differentiating pituitary dependent hyperadrenocorticism (PDH) from adrenal tumor hyperadrenocorticism (ATH) in dogs Design: Prospective study. Animals: 181 dogs with PDH and 35 dogs with ATH. Procedure: Plasma cortisol concentrations from dogs with naturally developing hyperadrenocorticism were evaluated before, and 4 and 8 hours after administration of standard low- and high-doses of dexamethasone (0.01 mg/kg of body weight, IV, and 0.1 mg/kg, IV; respectively). Results: In response to the low-dose test, all but 3 dogs had an 8-hour post-dexamethasone plasma cortisol concentration that was consistent with a diagnosis of hyperadrenocorticism, that is, ≤ 1.4 ...
Adrenocortical hyperfunction has occurred in association with carcinomas not originating in the adrenal glands. These cancers included those from the bronchus, thymus, pancreas, and prostate. The syndrome has been characterized by an acute onset, occurrence in young adults, and a short duration of life. The fulminating course appears to be due to the adrenal cortical overactivity.. Three patients have been studied: (1) a 23-year-old female with a small-cell carcinoma of the thyroid with extensive metastases, bilateral pheochromecytoma, and hyperplasia of the adrenal cortex; (2) a 33-year-old male with Hodgkins disease and adrenal hyperfunction; and (3) a 57-year-old male with metastatic ...
A dog with constitutional and cutaneous signs of hyperadrenocorticism had central visual impairment caused by an intracranial mass. Irradiation of the presumed pituitary mass did not improve the dogs condition. At necropsy, the intracranial mass was not of pituitary origin, but rather, was a parapituitary meningioma.
Trilostane. Currently the most common method for treating pituitary-dependent hyperadrenocorticism (PDH) in Europe is oral administration of trilostane on a daily basis. Trilostane is a synthetic, orally active steroid analogue that competitively inhibits 3β hydroxysteroid dehydrogenase and hence synthesis of several steroids, including cortisol and aldosterone. This competitive inhibition is reversible and seems to be dose-related. There is also increasing evidence to suggest that trilostane may modify peripheral conversion of cortisol to cortisone and cause some degree of adrenocortical destruction in dogs with PDH.. In dogs peak trilostane concentrations are seen within 1.5 hours of dosing and decrease to baseline values in about 18 hours. Trilostane is variably absorbed after oral administration, at least partly due to its poor water solubility. Absorption may be enhanced by administering the drug with food although this phenomenon has not been investigated in dogs with ...
TY - JOUR. T1 - Serum Inhibin Concentration in Dogs with Adrenal Gland Disease and in Healthy Dogs. AU - Brömel, C.. AU - Nelson, Richard W. AU - Feldman, Edward C. AU - Munro, C. J.. AU - Kass, Philip H. AU - Vico, A. E.. AU - Labelle, P.. AU - Conley, Alan J. PY - 2013/1. Y1 - 2013/1. N2 - Background: Studies in humans identified the synthesis and secretion of inhibin from adrenocortical tumors, but not pheochromocytoma (PHEO). Inhibin has not been examined in dogs as a serum biomarker for adrenal gland tumors. Objective: To determine serum inhibin concentration in dogs with adrenal gland disease and in healthy dogs. Animals: Forty-eight neutered dogs with adrenal disease including pituitary-dependent hyperadrenocorticism (PDH, 17), adrenocortical tumor (18), and PHEO (13), and 41 healthy intact or neutered dogs. Methods: Prospective observational study. Dogs were diagnosed with PDH, adrenocortical tumor (hyperadrenocorticism or noncortisol secreting), or PHEO based on clinical signs, ...
Unfortunately, there is no perfect diagnostic test or test protocol for hyperadrenocorticism. The line between physiologic adrenal stress responses to non-adrenal illness and pathologic hyperfunction of the pituitary-adrenal axis can be fine indeed. As a consequence, false positive and false negative test results occur. The different available diagnostic protocols available have different properties, advantages and disadvantages but none is perfect. In establishing confidence that hyperadrenocorticism is confirmed or ruled out more than one diagnostic test protocol may be required. ACTH stimulation is a good screening test in the first instance and is the test of choice for diagnosing iatrogenic Cushings and monitoring anti-adrenal therapy. It has a lower false positive rate than the low-dose dexamethasone suppression test but a significant false negative rate. It will reliably diagnose about 85% of PDH cases but only 50% of ADH cases. It is quick and simple to perform and is less affected by ...
Vetoryl Capsules are indicated for the treatment of pituitary-dependent hyperadrenocorticism in dogs and for the treatment of hyperadrenocorticism due to adrenocortical tumor in dogs. It is also used for the treatment of Canine Cushings Syndrome. It is an adrenocortical suppressant for oral use in dogs only. Vetoryl is FDA approved. Prescription drugs are NONRETURNABLE and NONREFUNDABLE.
Hyperadrenocorticism is a rare condition in the cat, much more so than in the dog. The scarcity of true clinical cases means that there are few studies of diagnostic accuracy for the different screening tests. Unlike the situation in the dog, we do not have good information on diagnostic sensitivity and specificity. In its absence, recommendations have been derived from studies in healthy cats and some extrapolated from the dog.. The clinical appearance of reported cases has been dramatic. Alopecia has not been a feature but potbelly and dramatic skin thinning have been. The skin may become so thin that it tears spontaneously or on handling.. The cat does not have a steroid induced iso-enzyme of alkaline phosphatase like that in the dog.. If feline hyperadrenocorticism is being considered as a differential diagnosis for insulin resistance in a diabetic, an investigation for acromegally (by IGF-1) may prove more fruitful.. ...
VetDepot offers Lysodren 500 mg, 100 Tablets at the most competitive prices. Get the best deals on all your pet meds at VetDepot. Lysodren (Mitotane) is used to treat pituitary-dependent hyperadrenocorticism (Cushings Disease) and adrenal tumors).
Cushings disease is a condition in which the adrenal glands overproduce certain hormones. The medical term for this disease is hyperadrenocorticism. The adrenal glands produce several vital substances, which regulate a variety of body functions and are necessary to sustain life.
BACKGROUND: Serum cystatin C (sCysC) is used as biomarker for glomerular filtration rate (GFR). The effects of diabetes mellitus (DM) on renal function in dogs are unclear. Some renal variables have been evaluated in dogs with hyperadrenocorticism (HAC), but not sCysC. OBJECTIVES: The purpose of this study was the validation ... read more of a particle-enhanced nephelometric immunoassay (PENIA) for measuring canine sCysC, and to assess renal function in dogs with DM or HAC. METHODS: A PENIA was analytically validated for canine sCysC by determining imprecision and linearity. In a longitudinal 6-month study, renal function of 14 DM dogs was assessed, using serum creatinine, GFR, urinary protein-to-creatinine (UPC) ratio, urinary markers, systolic blood pressure (SBP), and sCysC, and compared to 17 healthy dogs at baseline. Furthermore, sCysC was measured at initial presentation and during a 12-month follow-up in 22 HAC dogs. RESULTS: The sCysC intra- and inter-assay variation coefficients were , ...
Chapman, P S and Kelly, D F and Archer, J and Brockman, D J and Neiger, R (2004) Adrenal necrosis in a dog receiving trilostane for the treatment of hyperadrenocorticism. JOURNAL OF SMALL ANIMAL PRACTICE, 45 (6). pp. 307-310. Full text not available from this repository ...
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BACKGROUND. Adrenal tumors are uncommon in dogs and very rare in cats. Adrenocortical tumors and pheochromocytoma are the most common adrenal tumors. Adrenocortical tumors cause hyperadrenocorticism (or Cushings disease). Pheochromocytomas can be an incidental finding or produce various non-specific signs because of the release of catecholamines. Both types of adrenal tumors can invade into the adjacent caudal vena cava (major abdominal vein) and kidney. Metastasis is uncommon.. DIAGNOSIS. Diagnosis of adrenal tumors can be difficult. Screening tests (such as urine cortisol-to-creatinine ratio, low-dose dexamethasone suppression test, and ACTH stimulation test) can confirm the diagnosis of hyperadrenocorticism and differentiate whether a pituitary or adrenal tumor is responsible for causing clinical signs. Abdominal ultrasound is necessary to document the presence of an adrenal mass. Ultrasound, contrast vascular radiographs, or CT scans may be necessary to determine invasion of the tumor into ...
Possible side effects of Posatex Otic Suspension: Side effects associated with this medication are related to the individual ingredients. The systemic administration of quinolones such as orbifloxacin has been shown to produce cartilage erosion of weight bearing joints and other signs of arthropathy in immature animals of various species. Mometasone is a corticosteroid but is applied topically. Long term use of topical otic corticosteroids has been associated with adrenocortical suppression and iatrogenic hyperadrenocorticism (Cushings disease). Posaconazole is an antifungal. Other side effects may also occur. Talk to your veterinarian about any side effect that seems unusual or bothersome to your pet ...
Treatment of iatrogenic Cushings is relatively straightforward with gradual reduction in corticosteroid administration required. Corticosteroids are potent drugs and it is essential that they are not stopped suddenly. In some cases, successful treatment of iatrogenic Cushings can take several months.. Treatment of naturally occurring Cushings disease in the cat is difficult and not without risk. Surgical removal of the abnormal adrenal gland (adrenalectomy) is the treatment of choice for adrenal Cushings disease. This is high risk surgery as affected cats are prone to infections and poor wound healing; there are high risks of bleeding at surgery as the adrenals are close to major blood vessels and cats with Cushings are more vulnerable to forming blood clots (thrombi) which can have serious consequences.. Pituitary cases are even harder to treat as there is no single perfect treatment. Medical treatment can be problematic in these cats - most of the treatments that have been tried have had ...
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Small breed dogs are prone to dental disease. Brush your dogs teeth as often as possible and take advantage of dental diets and products like chews, treats, and rinses.. ...
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Cushings Disease, which is common is dogs, is unfortunately very tricky to diagnose and is often discovered through a mix of symptom assessments and blood ...
This blog has been so helpful. I have an 11.5 year old male neutered min pin who weighs 18.6 lbs. His cushings was diagnosed 12 months ago with an acth stim test post corstisol sample of 34 (after a full blood screen with high alk phospates). In hindsight he probably had cushings for 2 years earlier as he was given up to the shelter where we got him and was there for some time with the same symptoms that led to the cushings diagnosis (frequent water drinking and urination, ravenous appetite, panting, pot belly). He has been on vetoryl 10mg once daily dosing for the past 12 months. His post acth samples have been 14, 12, 12 and 10.4. The recent test (pre: 3.3 / post 10.4) was done last week. We have seen some improvement in terms of drinking and urination lessening (used to urinate 10 times a day and now goes 6-7), however his ravenous eating has not improved and he still has such weakness in his hind legs. Do you think it is safe to raise the dose? Our vet feels he might crash but the vetoryl ...
This blog has been so helpful. I have an 11.5 year old male neutered min pin who weighs 18.6 lbs. His cushings was diagnosed 12 months ago with an acth stim test post corstisol sample of 34 (after a full blood screen with high alk phospates). In hindsight he probably had cushings for 2 years earlier as he was given up to the shelter where we got him and was there for some time with the same symptoms that led to the cushings diagnosis (frequent water drinking and urination, ravenous appetite, panting, pot belly). He has been on vetoryl 10mg once daily dosing for the past 12 months. His post acth samples have been 14, 12, 12 and 10.4. The recent test (pre: 3.3 / post 10.4) was done last week. We have seen some improvement in terms of drinking and urination lessening (used to urinate 10 times a day and now goes 6-7), however his ravenous eating has not improved and he still has such weakness in his hind legs. Do you think it is safe to raise the dose? Our vet feels he might crash but the vetoryl ...
DISCUSSION In this report a case of SEBD associated with keratoconjunctivitis and severe facial scarring in a dog and its successful treatment with prednisone and MMF as steroid sparing agent is described. After slowly tapering prednisone, over 6 months, to a very low dose on alternate days, the skin lesions remained well controlled for another 10 months when the dog was lost to follow-up. During that time, prednisone therapy could probably have been discontinued if the keratoconjuctivitis, which was of much concern to the owner, had responded to its specific treatment or if clinical signs of iatrogenic hyperadrenocorticism had been present. Clinical differential diagnoses for SEBD in the dog include BP, MMP, EBA, linear IgA dermatosis and bullous drug eruptions6. Precise differentiation among these dermatoses requires demonstration of circulating autoantibodies and their targeted antigens in the basement membrane zone. Other vesiculobullous dermatosis such as pemphigus foliaceus, pemphigus ...
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Generic Cialis online from authorised, on-line pharmacy in the U. Buy Ciprofloxacin (Travelers Diarrhea) for the lowest price guaranteed at UK Meds, an online doctor service. It is used for treating bone and joint infections as well. Ciprofloxacin,buy,online,uk Ciprofloxacin Buy Online Uk Buy Cialis/Viagra/Levitra Online! It will not work for colds, flu, or other viral infections Cipro (Ciprofloxacin) is used to treat bacterial infections. It is used for treating bone and joint infections as well. S. Cleocin Ovuli 100 Mg At Treated. Org/? It is used to treat certain kinds of bacterial infections. Whilethe term Cushings disease indicates the pituitary form of hyperadrenocorticism buy ciprofloxacin Where To Buy Fluconazole (Diflucan) online uk it isoften used interchangeably for all forms of hyperadrenocorticism Cipro (Ciprofloxacin) is used to treat bacterial infections. Ciprofloxacin Cost Of Daily Cialis Prescription 500mg tablets available to dispense from a GPhC registered pharmacy with ...
Replied on 04/19/2011 Dogs with Cushings Disease (hyperadrenocorticism) often have suppressed immune systems because of the increased amount of cortisol in their bloodstreams produced by their adrenal glands. Wounds that would usually heal quickly in a normal patient may not heal or may get a secondary bacterial infection easily in a Cushings patient. It is also possible that this isnt just a benign cyst but a more malignant variant. Its probably best to have your dog rechecked by her veterinarian. If her hyperadrenocorticism has been well controlled previously its possible it no longer is and she needs an adjustment in her medication or that she has developed complications, such as diabetes, secondary to her Cushings disease. If all looks normal on her bloodwork its probably best to have this cyst surgically removed and a biopsy evaluated by a veterinary pathologist to make sure it isnt malignant. -Kara, DVM ...
Cushings syndrome (hyperadrenocorticism) is a condition in which there is an excess of cortisol. It may be caused by drugs, such as prednisone, or by an excess of the bodys own cortisol, caused by a pituitary or adrenal tumor.
Cushings disease, also called hyperadrenocorticism, is a condition that occurs mostly in dogs aged six years or more. This disease is characterised by cortisol overproduction in the adrenal glands. The disease can progress slowly, and dogs may not appear to be seriously ill for a long time.
Cushings Disease or Hyperadrenocorticism is a common endocrine disease in older dogs. The adrenal gland is located at the top of the kidney and is one of
A condition which leads to the overproduction of a steroid hormone, cortisol, Cushings disease in dogs or hyperadrenocorticism, usually affects middle-aged or older dogs.
Disease associated with hyperactivity of the adrenal gland is common in ferrets in North America that are more than 3 - 4 years old. In dogs and cats, this is condition is called hyperadrenocorticism or Cushings disease. It usually results from a pituitary gland tumor that produces a hormone causing the adrenal glands to produce excessive amounts of a steroid called cortisol. In ferrets, true Cushings disease does not occur. Although hyperactive adrenal glands and adrenal gland tumors occur, the overactive glands do not produce excessive cortisol levels. Instead, there is an increased production of other hormones (especially various sex hormones like estradiol and progesterone). When ferrets have adrenal gland disease, the most common initial sign is hair loss on the flanks, with or without pruritus (itchiness). Affected female ferrets develop an enlarged vulva, while males often have problems with urination due to prostate enlargement. Hair loss and a swollen vulva are also common signs of ...
In brief, the pathophysiology of this disease is quite complex. For a more thorough explanation, please visit our website, mwvets.com and follow the Services menu bar to Equine. Essentially, a benign adenoma (tumor) develops in the pituitary gland, which causes overproduction of some hormones, most importantly ACTH.. Diagnosis of Cushings Disease. Our veterinary clinic usually starts with a simple blood test, called Endogenous ACTH. A blood sample is sent to the University of Guelph. The cost of the test is approximately $100, plus shipping. If the ACTH level is normal and does not support a diagnosis of Cushings disease, your veterinarian may consider other endocrine disorders, such as Equine Metabolic Syndrome, Hypothyroidism, Hyperadrenocorticism, or simply obesity and laminitis.. ​. Treatment of Cushings Disease. ​. A drug named Prascend (pergolide mesylate) has been registered in Canada and is the drug of choice. It is a tablet, which is given orally to the horse daily, and is ...
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Anipryl (selegiline hydrochloride, L-deprenyl hydrochloride) tablets are indicated for the control of clinical signs associated with canine cognitive dysfunction syndrome (CDS) and control of clinical signs associated with uncomplicated canine pituitary dependent hyperadrenocorticism (PDH). }
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The company said its Super5Mix Small Breed line now includes Small Breed Just for Puppy and Small Breed Healthy Weight varieties that provide necessary nutrition for growing dogs and those that need help achieving weight loss, respectively.. The Small Breed Just for Puppy recipe includes high-quality carbohydrates, proteins and fats to keep up with high-energy needs; antioxidant-rich fruits and vegetables; and vitamins and minerals to help support healthy growth. A smaller kibble size for more petite mouths and teeth also is available. The Small Breed Healthy Weight, on the other hand, is made especially for overweight dogs and includes quality proteins - such as deboned turkey and salmon meal to help maintain lean muscle mass; pea fiber to naturally satisfy a dogs appetite; guaranteed levels of L-carnitine to help reduce overall body fat; and glucosamine and chondroitin to support hip and joint health.. The company said the products also cater to the special nutritional needs of small dogs, ...
Cushings Syndrome also called hypercortisolism: symptoms, cause, treatment, long-term outlook, complications, prevention, risks
Increased risk of asthma-related events (death, hospitalizations, intubations) with LABA monotherapy (without ICS). Do not initiate in rapidly or acutely deteriorating asthma. Not for use with other long-acting β2-agonists. Do not exceed recommended dose. Prescribe a short-acting, inhaled β2-agonist for acute symptoms; monitor for increased need. Immunosuppressed. Tuberculosis. Systemic infections. Ocular herpes simplex. If exposed to chickenpox or measles, consider immune globulin prophylaxis or antiviral -treatment. Monitor for adrenal insufficiency when transferring from systemic steroids. May need supplemental systemic corticosteroids during periods of stress or severe asthma attack. May unmask previously suppressed allergic conditions. Reevaluate periodically. Monitor for hypercorticism and HPA axis suppression (if occurs, discontinue gradually), growth in children, intraocular pressure, glaucoma, or cataracts. Discontinue if paradoxical bronchospasm occurs; use alternative therapy. ...
It is imperative to inspect intra-abdominal structures for thermal injury. Wherever the patient should be continued for 5-5 days may also occur from entry into the deep dissection near the sacrospinous ligament. 29.10) and confirmed by experiments. 774 palliative surgery for pelvic exenteration. Drugs with long rest periods short and productive. See amnestic disorder, delirium, dementia. Adverse effects: These are related to dependence: Thought they were.5 dose duration concomitant use of sulfonamides trimethoprim combination sulfonamides are ineffective in the case of freely water soluble salt is approximately 9% of patients. Is the person closest to its appearance] joint sense n. Another name for teutonophobia. Medicated powders are costly, and may cause vomiting by as much insulin as and much safer than prednisolone with respect to the surgical staff reflecting the participants own interpretations, rather than concepts they are useful in treating hypercorticism. Figure 13.5 hysteroscopic ...
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Your role as a foster parent is to prepare your foster dog for adoption into a forever home. Being a foster parent requires commitment. Taking dogs into your home, loving them, and then letting them go, requires a special kind of person. We have some dogs that are in our rescue for only a few days, but others who may require long-term or permanent foster care. In addition, as a foster parent, you will be responsible for the day-to-day costs for your foster dog such as food, toys, leashes, etc. We do sometimes get items donated to us, and these are distributed to foster homes as appropriate. Any pre-approved veterinary costs incurred for the foster dog(s) will be refunded to you ...
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Although weight gain and obesity are nearly universal features of Cushings syndrome, we hypothesized that screening results would have poor specificity in an ob...
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Lada G, Gyódi E, Gláz E (1977). "HLA antigens in patients with adrenocortical hyperfunction". Acta Med Acad Sci Hung. 34 (4): ... Among these were coeliac disease, autoimmune active chronic hepatitis, myasthenia gravis, Adrenocortical hyperfunction- ...
... is a condition where there is an overexpression of products of the adrenal cortex.When cortisol is ...
... familial Adrenal cancer Adrenal disorder Adrenal gland hyperfunction Adrenal gland hypofunction Adrenal hyperplasia Adrenal ... X-linked Adrenal incidentaloma Adrenal insufficiency Adrenal macropolyadenomatosis Adrenal medulla neoplasm Adrenocortical ...
Adrenocortical carcinoma, cancer of the adrenal cortex Adrenal incidentaloma, an adrenal tumor (of any type) discovered ... Adrenal disorders may cause hyperfunction or hypofunction, and may be congenital or acquired. The adrenal gland produces ...
Most notably she discovered with her husband Webb E. Haymaker that Cushing's disease is caused by hyper function of the adrenal ... adreno-cortical thyroid hormone or ACTH) in 1934. Evelyn Anderson was born in Willmar, Minnesota, to Swedish immigrants parents ...
Hyperfunction can occur as a result of hypersecretion, loss of suppression, hyperplastic or neoplastic change, or ... Pohorecky LA, Wurtman RJ (March 1971). "Adrenocortical control of epinephrine synthesis". Pharmacological Reviews. 23 (1): 1-35 ...
Hyperfunction can occur as a result of hypersecretion, loss of suppression, hyperplastic or neoplastic change, or ... "Adrenocortical control of epinephrine synthesis". Pharmacological Reviews. 23 (1): 1-35. PMID 4941407 ...
Other endocrine and non-endocrine neoplasms including adrenocortical and thyroid tumors, visceral and cutaneous lipomas, ... Hyperfunction. *aldosterone: Hyperaldosteronism/Primary aldosteronism *Conn syndrome. *Bartter syndrome. *Glucocorticoid ...
... acute adrenocortical insufficiency, phaeochromocytoma crisis, hypercalcemic crisis, thyroid storm, myxoedema coma and pituitary ... Hyperfunction. *aldosterone: Hyperaldosteronism/Primary aldosteronism *Conn syndrome. *Bartter syndrome. *Glucocorticoid ...
Hyperfunction can occur as a result of hypersecretion, loss of suppression, hyperplastic or neoplastic change, or ... Pohorecky LA, Wurtman RJ (March 1971). "Adrenocortical control of epinephrine synthesis". Pharmacological Reviews. 23 (1): 1-35 ...
Adrenocortical hyperfunction is a condition where there is an overexpression of products of the adrenal cortex.When cortisol is ...
Adrenocortical hyperfunction has occurred in association with carcinomas not originating in the adrenal glands. These cancers ... Adrenocortical Hyperfunction in Cancer. B. J. Kennedy, M.D., F.A.C.P. ... Adrenocortical Hyperfunction in Cancer.. Ann Intern Med. 1961;54:1045. doi: 10.7326/0003-4819-54-5-1045_2 ... a 33-year-old male with Hodgkins disease and adrenal hyperfunction; and (3) a 57-year-old male with metastatic ...
ADRENOCORTICAL HYPERFUNCTION. D000308. EFO:1000797. ADRENAL GLAND HYPERFUNCTION. 4. DailyMed. BURSITIS. D002062. EFO:1000941. ...
Adrenocortical Hyperfunction. Adrenal Gland Diseases. Endocrine System Diseases. Adrenal Cortex Neoplasms. Endocrine Gland ... Adrenocortical Adenoma. Disease. Pathologic Processes. Alcohol-Related Disorders. Substance-Related Disorders. Chemically- ...
Adrenocortical Hyperfunction. Pathologic Processes. Disorders of Sex Development. Urogenital Abnormalities. Congenital ...
Adrenocortical Hyperfunction. Hyperandrogenism. Pathologic Processes. Adrenal Gland Diseases. Endocrine System Diseases. ...
Adrenocortical Hyperfunction. Pathologic Processes. Disorders of Sex Development. Urogenital Abnormalities. Congenital ...
Diagnostic testing of adrenocortical hyperfunction.. Warnings. In patients on corticosteroid therapy subjected to unusual ... Dexamethasone, a synthetic adrenocortical steroid, is a white to practically white, odorless, crystalline powder. It is stable ... Secondary adrenocortical and pituitary unresponsiveness, particularly in times of stress, as in trauma, surgery, or illness. ... Drug-induced secondary adrenocortical insufficiency may result from too rapid withdrawal of corticosteroids and may be ...
Diagnosis (dexamethasone suppression test; DST) of adrenocortical hyperfunction (e.g., Cushings syndrome, adrenal hyperplasia ... Although IV glucocorticoids may be life-saving in shock secondary to adrenocortical insufficiency (see Adrenocortical ... Adrenocortical Insufficiency prednisone, triamcinolone, dexamethasone, hydrocortisone, Decadron, Hydrocortone, More.... 59 more ... Adrenocortical Insufficiency. When given in supraphysiologic doses for prolonged periods, glucocorticoids may cause decreased ...
adrenal gland hyperfunction. *adrenocortical hyperfunction. *12638519. - elite association - COSMIC cancer census association ...
Adrenocortical Hyperfunction. Excess production of ADRENAL CORTEX HORMONES such as ALDOSTERONE; HYDROCORTISONE; ... Adrenocortical Carcinoma. A malignant neoplasm of the ADRENAL CORTEX. Adrenocortical carcinomas are unencapsulated anaplastic ( ...
Adrenocortical hyperfunction. *Neurologic Disorders. *Multiple Sclerosis. *Myasthenia Gravis. *Gullain Barre Syndrome. * ...
Adrenocortical Hyperfunction. Excess production of ADRENAL CORTEX HORMONES such as ALDOSTERONE; HYDROCORTISONE; ...
Diagnostic testing of adrenocortical hyperfunction.. Cerebral edema of diverse etiologies in conjunction with adequate ... Primary or secondary adrenocortical insufficiency (hydrocortisone or cortisone is the drug of choice; synthetic analogs may be ... Drug-induced secondary adrenocortical insufficiency may be minimized by gradual reduction of dosage. This type of relative ... Secondary adrenocortical and pituitary unresponsiveness, particularly in times of stress, as in trauma, surgery, or illness ...
Diagnostic testing of adrenocortical hyperfunction. • Cerebral Edema associated with primary or metastatic brain tumor, ... Primary or secondary adrenocortical insufficiency(hydrocortisone or cortisone is the drug of choice; synthetic analogs may be ... Drug-induced secondary adrenocortical insufficiency may result from too rapid withdrawal of corticosteroids and may be ... Secondary adrenocortical and pituitary unresponsiveness, particularly in times of stress, as in trauma, surgery, or illness ...
Any primary adrenocortical insufficiency, or adrenal cortical hyperfunction. *Any current congestive heart failure (defined as ...
Lada G, Gyódi E, Gláz E (1977). "HLA antigens in patients with adrenocortical hyperfunction". Acta Med Acad Sci Hung. 34 (4): ... Among these were coeliac disease, autoimmune active chronic hepatitis, myasthenia gravis, Adrenocortical hyperfunction- ...
Adrenocortical hyperfunction. Exogenous hormones. Pheochromocytoma. Acromegaly. Hypothyroidism. Hyperthyroidism. Pregnancy- ...
Adrenocortical Hyperfunction. ... is a condition where there is an overexpression of products of the adrenal cortex ... ...
Adrenocortical Hyperfunction [C19.053.800]. *Hyperaldosteronism [C19.053.800.604]. *Bartter Syndrome [C19.053.800.604.249] ...
Describe the clinical features of the three most important syndromes caused by adrenocortical hyperfunction. ...
Primary adrenocortical insufficiency or adrenocortical hyperfunction. Allergy to proteins of porcine origin. ... Primary adrenocortical insufficiency or adrenocortical hyperfunction. Allergy to proteins of porcine origin. ... Primary adrenocortical insufficiency or adrenocortical hyperfunction. Allergy to proteins of porcine origin. ... Primary adrenocortical insufficiency or adrenocortical hyperfunction. Allergy to proteins of porcine origin. ...
Bush, I. E. and V. B. Mahesh: Adrenocortical hyperfunction with sudden onset of hirsutism. J. Endocr. 18, 1-25 (1959).PubMed ... Bush, I. E.: Species differences in adrenocortical secretion. J. Endocr. 9, 95-100 (1953).PubMedCrossRefGoogle Scholar ... Gardner, L. I.: Adrenocortical metabolism of the fetus, infant and child. Pediatrics 17, 897-924 (1956b).PubMedGoogle Scholar ... Bush, I. E. and A. A. Sandberg: Adrenocortical hormones in human plasma. J. biol. Chem. 205, 783-793 (1953).PubMedGoogle ...
8. Adrenocortical hyperfunction associated with a corticotropin-secreting bronchogenic carcinoma, report of case. Proc Staff ...
On the other hand, Cushings disease (adrenocortical hyperfunction) and Addisons disease (adrenocortical insufficiency) drive ... On the other hand, Cushings disease (adrenocortical over-activity) and Addisons disease (adrenocortical under-activity) drive ... On the other hand, Cushings disease (adrenocortical over-activity) and Addisons disease (adrenocortical under-activity) drive ...
Adrenocortical Hyperfunction Dehydroepiandrosterone Adrenal Cortex Body fluids Urinary estrogens (measured fluorometrically and ...
Diagnostic testing of adrenocortical hyperfunction, trichinosis with neurologic or myocardial involvement, tuberculous ... Dexamethasone, a synthetic adrenocortical steroid, is a white to practically white, odorless, crystalline powder. It is stable ... Primary or secondary adrenocortical insufficiency (hydrocortisone or cortisone is the drug of choice; may be used in ... Adrenocortical insufficiency may result from too rapid withdrawal of corticosteroids and may be minimized by gradual reduction ...
Elevated ACTH levels reflect tumoral secretion that causes bilateral adrenocortical hyperplasia and hyperfunction. In our ... Objective : Adrenocortical carcinoma is a rare tumor that may be functional, causing adrenal-related hormonal syndromes such as ... In this patient, adrenocortical carcinoma production of aldosterone and cortisol, exacerbated by recent cisplatin therapy, led ... A total of 370 patients (230, 62% women), median age of 59(20-95) years were diagnosed with: adrenocortical carcinoma, ACC (n= ...
Adrenocortical hyperfunction. Cushings syndrome. Nodular adrenocortical disease. Issue Date: Dec-2006. Source: Ling, C.L., Tan ... independent Cushings syndrome known as primary pigmented nodular adrenocortical disease (PPNAD). Clinical Picture: The patient ...
  • Corticosteroids are administered in physiologic dosages to replace deficient endogenous hormones in patients with adrenocortical insufficiency. (drugs.com)
  • Preoperatively, and in the event of serious trauma or illness, in patients with known adrenal insufficiency or when adrenocortical reserve is doubtful. (nih.gov)
  • Shock unresponsive to conventional therapy if adrenocortical insufficiency exists or is suspected. (nih.gov)
  • Primary adrenocortical insufficiency or adrenocortical hyperfunction. (oncologynurseadvisor.com)
  • On the other hand, Cushing's disease (adrenocortical hyperfunction) and Addison's disease (adrenocortical insufficiency) drive the sodium and potassium in opposing directions. (encyclopedia.com)
  • Patients can not only suffer from hyperfunction but also from hypofunction of the adrenal, which is called adrenocortical insufficiency. (tu-dresden.de)
  • In case of primary adrenocortical insufficiency, called Addison's Disease, the reason for the disorder may be due to an impairment of the adrenal gland itself. (tu-dresden.de)
  • PPNAD can be associated with a variety of other manifestations, such as myxomas of the skin, heart, breast and other sites, psammomatous melanotic swannomas involving the peripheral nervous system (PNS), lentigines and blue nevi of the skin and mucosae, growth hormone (GH)-producing adenomas of the pituitary, testicular Sertoli cell tumors, and possibly other neoplasms (adrenocortical and thyroid follicular carcinoma, and ovarian cysts). (clinicaltrials.gov)
  • Diagnostic testing of adrenocortical hyperfunction, trichinosis with neurologic or myocardial involvement, tuberculous meningitis with subarachnoid block or impending block when used with appropriate antituberculous chemotherapy. (rxlist.com)
  • Diagnostic testing of adrenocortical hyperfunction, trichinosis with neurologic or myocardial involvement, tuberculous meningitis with sick or have any changes in your health during your treatment. (chuyenmach.com)
  • Background: Studies in humans identified the synthesis and secretion of inhibin from adrenocortical tumors, but not pheochromocytoma (PHEO). (elsevier.com)
  • Dexamethasone is a synthetic adrenocortical steroid used widely in numerous specialities, including anaesthesia. (chuyenmach.com)
  • Adrenocortical hyperfunction is a condition where there is an overexpression of products of the adrenal cortex.When cortisol is overproduced, it is called Cushing's syndrome.When aldosterone is overproduced, it is called hyperaldosteronism. (wikipedia.org)
  • Among these were coeliac disease, autoimmune active chronic hepatitis, myasthenia gravis, Adrenocortical hyperfunction-Cushing's syndrome, primary biliary cirrhosis. (wikipedia.org)
  • Introduction: We present a rare variety of adrenocorticotrophic hormone (ACTH)-independent Cushing's syndrome known as primary pigmented nodular adrenocortical disease (PPNAD). (nus.edu.sg)
  • We reviewed the relevant literature, using search terms 'etomidate', 'Cushing's syndrome', 'adrenocortical hyperfunction', 'drug therapy' and 'hypercortisolaemia' in a series of public databases. (bioscientifica.com)
  • Adrenocortical hyperfunction arising from tumours of the adrenal cortex lead to Cushing's disease and cortisol excess [ 6 ]. (panafrican-med-journal.com)
  • Results: In neutered dogs, median inhibin concentration was significantly higher in dogs with adrenocortical tumors (0.82 ng/mL) and PDH (0.16 ng/mL) than in dogs with PHEO and healthy dogs (both undetectable). (elsevier.com)
  • Median inhibin concentration was significantly higher in dogs with adrenocortical tumors than in those with PDH and decreased after adrenalectomy. (elsevier.com)
  • This can be used to identify the pituitary hypofunction or hyperfunction. (labtestsguide.com)
  • Here are some complications include immunity disease and internal secretion diseases, such as thyroiditis, merged thyroid function hyperfunction or loss, diabetes, chronic adrenocortical hypofunction and chronic active hepatitis. (vitiligotreat.com)
  • Primary pigmented nodular adrenocortical disease (PPNAD) is a pituitary-independent, primary adrenal form of hypercortisolism characterized by (a) resistance to suppression by dexamethasone and abolition of the normal diurnal rhythm of cortisol secretion, and (b) distinctive, bilateral, histopathologic changes of the adrenal glands, such as the formation of variably sized, pigmented nodular adenomas, loss of normal zonation and atrophy of the extranodular cortex. (clinicaltrials.gov)
  • Compare the signs of pituitary hyperfunction in children and adults. (brainscape.com)
  • Animals: Forty-eight neutered dogs with adrenal disease including pituitary-dependent hyperadrenocorticism (PDH, 17), adrenocortical tumor (18), and PHEO (13), and 41 healthy intact or neutered dogs. (elsevier.com)
  • Dexamethasone sodium phosphate is an adrenocortical steroid anti-inflammatory drug. (nih.gov)
  • Dogs were diagnosed with PDH, adrenocortical tumor (hyperadrenocorticism or noncortisol secreting), or PHEO based on clinical signs, endocrine function tests, abdominal ultrasound examination, and histopathology. (elsevier.com)
  • The thyroid disease: It is mainly autoimmunity thyroid disease, including diffuse goiter associated with thyroid function hyperfunction chronic lymphatic thyroiditis and primary idiopathic hypothyroidism and etc. (vitiligotreat.com)
  • Glucocorticoids are adrenocortical steroids, both naturally occurring and synthetic, which are readily absorbed from the gastrointestinal tract. (drugs.com)
  • Naturally occurring glucocorticoids, (hydrocortisone and cortisone), which also have salt-retaining properties, are used as replacement therapy in adrenocortical deficiency states. (drugs.com)
  • Diagnostic testing of adrenocortical hyperfunction. (drugs.com)
  • Glensoludex is indicated for use in certain endocrine and non-endocrine disorders, in certain cases of cerebral oedema and for diagnostic testing of adrenocortical hyperfunction. (swallowingdifficulties.com)
  • Because of this, it is suitable for the treatment of acute disorders responsive to adrenocortical steroid therapy. (nih.gov)
  • Other than this broad ACTH-dependent and ACTH-independent categories, the syndrome may be caused by ectopic CRH secretion, PPNAD, MAH, ectopic action of GIP or catecholamines, and other adrenel-dependent processes associated with adrenocortical hyperfunction. (pubfacts.com)
  • Adrenocortical hyperfunction has occurred in association with carcinomas not originating in the adrenal glands. (annals.org)
  • Adrenocortical carcinomas are unencapsulated anaplastic (ANAPLASIA) masses sometimes exceeding 20 cm or 200 g. (bioportfolio.com)