Adrenocortical adenoma. Medical search

A benign neoplasm of the ADRENAL CORTEX. It is characterized by a well-defined nodular lesion, usually less than 2.5 cm. Most adrenocortical adenomas are nonfunctional. The functional ones are yellow and contain LIPIDS. Depending on the cell type or cortical zone involved, they may produce ALDOSTERONE; HYDROCORTISONE; DEHYDROEPIANDROSTERONE; and/or ANDROSTENEDIONE.

Tumors or cancers of the ADRENAL CORTEX.

A benign epithelial tumor with a glandular organization.

A malignant neoplasm of the ADRENAL CORTEX. Adrenocortical carcinomas are unencapsulated anaplastic (ANAPLASIA) masses sometimes exceeding 20 cm or 200 g. They are more likely to be functional than nonfunctional, and produce ADRENAL CORTEX HORMONES that may result in hypercortisolism (CUSHING SYNDROME); HYPERALDOSTERONISM; and/or VIRILISM.

A condition caused by prolonged exposure to excess levels of cortisol (HYDROCORTISONE) or other GLUCOCORTICOIDS from endogenous or exogenous sources. It is characterized by upper body OBESITY; OSTEOPOROSIS; HYPERTENSION; DIABETES MELLITUS; HIRSUTISM; AMENORRHEA; and excess body fluid. Endogenous Cushing syndrome or spontaneous hypercortisolism is divided into two groups, those due to an excess of ADRENOCORTICOTROPIN and those that are ACTH-independent.

The outer layer of the adrenal gland. It is derived from MESODERM and comprised of three zones (outer ZONA GLOMERULOSA, middle ZONA FASCICULATA, and inner ZONA RETICULARIS) with each producing various steroids preferentially, such as ALDOSTERONE; HYDROCORTISONE; DEHYDROEPIANDROSTERONE; and ANDROSTENEDIONE. Adrenal cortex function is regulated by pituitary ADRENOCORTICOTROPIN.

A group of hydroxycorticosteroids bearing a hydroxy group at the 17-position. Urinary excretion of these compounds is used as an index of adrenal function. They are used systemically in the free alcohol form, but with esterification of the hydroxy groups, topical effectiveness is increased.

Pathological processes of the ADRENAL CORTEX.

Excision of one or both adrenal glands. (From Dorland, 28th ed)

Tumors or cancer of the ADRENAL GLANDS.

A condition caused by the overproduction of ALDOSTERONE. It is characterized by sodium retention and potassium excretion with resultant HYPERTENSION and HYPOKALEMIA.

The main glucocorticoid secreted by the ADRENAL CORTEX. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions.

An anterior pituitary hormone that stimulates the ADRENAL CORTEX and its production of CORTICOSTEROIDS. ACTH is a 39-amino acid polypeptide of which the N-terminal 24-amino acid segment is identical in all species and contains the adrenocorticotrophic activity. Upon further tissue-specific processing, ACTH can yield ALPHA-MSH and corticotrophin-like intermediate lobe peptide (CLIP).

A pair of glands located at the cranial pole of each of the two KIDNEYS. Each adrenal gland is composed of two distinct endocrine tissues with separate embryonic origins, the ADRENAL CORTEX producing STEROIDS and the ADRENAL MEDULLA producing NEUROTRANSMITTERS.

Examinations that evaluate and monitor hormone production in the adrenal cortex.

An enzyme that catalyzes the reduction of a 3 beta-hydroxy-delta(5)-steroid to 3-oxo-delta(4)-steroid in the presence of NAD. It converts pregnenolone to progesterone and dehydroepiandrosterone to androstenedione. EC 1.1.1.145.

A microsomal cytochrome P450 enzyme that catalyzes the 17-alpha-hydroxylation of progesterone or pregnenolone and subsequent cleavage of the residual two carbons at C17 in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP17 gene, generates precursors for glucocorticoid, androgen, and estrogen synthesis. Defects in CYP17 gene cause congenital adrenal hyperplasia (ADRENAL HYPERPLASIA, CONGENITAL) and abnormal sexual differentiation.

A hormone secreted by the ADRENAL CORTEX that regulates electrolyte and water balance by increasing the renal retention of sodium and the excretion of potassium.

Unanticipated information discovered in the course of testing or medical care. Used in discussions of information that may have social or psychological consequences, such as when it is learned that a child's biological father is someone other than the putative father, or that a person tested for one disease or disorder has, or is at risk for, something else.

A derivative of the insecticide DICHLORODIPHENYLDICHLOROETHANE that specifically inhibits cells of the adrenal cortex and their production of hormones. It is used to treat adrenocortical tumors and causes CNS damage, but no bone marrow depression.

A usually benign, well-encapsulated, lobular, vascular tumor of chromaffin tissue of the ADRENAL MEDULLA or sympathetic paraganglia. The cardinal symptom, reflecting the increased secretion of EPINEPHRINE and NOREPINEPHRINE, is HYPERTENSION, which may be persistent or intermittent. During severe attacks, there may be HEADACHE; SWEATING, palpitation, apprehension, TREMOR; PALLOR or FLUSHING of the face, NAUSEA and VOMITING, pain in the CHEST and ABDOMEN, and paresthesias of the extremities. The incidence of malignancy is as low as 5% but the pathologic distinction between benign and malignant pheochromocytomas is not clear. (Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1298)

Excess production of ADRENAL CORTEX HORMONES such as ALDOSTERONE; HYDROCORTISONE; DEHYDROEPIANDROSTERONE; and/or ANDROSTENEDIONE. Hyperadrenal syndromes include CUSHING SYNDROME; HYPERALDOSTERONISM; and VIRILISM.

Histochemical localization of immunoreactive substances using labeled antibodies as reagents.

An anti-inflammatory 9-fluoro-glucocorticoid.

A benign, slow-growing tumor, most commonly of the salivary gland, occurring as a small, painless, firm nodule, usually of the parotid gland, but also found in any major or accessory salivary gland anywhere in the oral cavity. It is most often seen in women in the fifth decade. Histologically, the tumor presents a variety of cells: cuboidal, columnar, and squamous cells, showing all forms of epithelial growth. (Dorland, 27th ed)

An adenoma of the large intestine. It is usually a solitary, sessile, often large, tumor of colonic mucosa composed of mucinous epithelium covering delicate vascular projections. Hypersecretion and malignant changes occur frequently. (Stedman, 25th ed)

Tomography using x-ray transmission and a computer algorithm to reconstruct the image.

Neoplasms which arise from or metastasize to the PITUITARY GLAND. The majority of pituitary neoplasms are adenomas, which are divided into non-secreting and secreting forms. Hormone producing forms are further classified by the type of hormone they secrete. Pituitary adenomas may also be characterized by their staining properties (see ADENOMA, BASOPHIL; ADENOMA, ACIDOPHIL; and ADENOMA, CHROMOPHOBE). Pituitary tumors may compress adjacent structures, including the HYPOTHALAMUS, several CRANIAL NERVES, and the OPTIC CHIASM. Chiasmal compression may result in bitemporal HEMIANOPSIA.

A benign epithelial tumor of the LIVER.

A mitochondrial cytochrome P450 enzyme that catalyzes the 11-beta-hydroxylation of steroids in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP11B1 gene, is important in the synthesis of CORTICOSTERONE and HYDROCORTISONE. Defects in CYP11B1 cause congenital adrenal hyperplasia (ADRENAL HYPERPLASIA, CONGENITAL).

A synthetic peptide that is identical to the 24-amino acid segment at the N-terminal of ADRENOCORTICOTROPIC HORMONE. ACTH (1-24), a segment similar in all species, contains the biological activity that stimulates production of CORTICOSTEROIDS in the ADRENAL CORTEX.

The wide middle zone of the adrenal cortex. This zone produces a series of enzymes that convert PREGNENOLONE to cortisol (HYDROCORTISONE) via 17-ALPHA-HYDROXYPROGESTERONE.

Conditions in which the production of adrenal CORTICOSTEROIDS falls below the requirement of the body. Adrenal insufficiency can be caused by defects in the ADRENAL GLANDS, the PITUITARY GLAND, or the HYPOTHALAMUS.

Primary aldosteronism with aldosterone-producing adrenal adenoma in a pregnant woman. (1/137)

A 30-year-old pregnant woman complained of muscle weakness at 29 weeks' gestation. She was hypertensive with severe hypokalemia. Lower plasma renin activity and higher aldosterone level than the normal values in pregnancy suggested primary aldosteronism. A cesarean delivery was performed at 31 weeks' gestation because of pulmonary congestion. The neonatal course was uncomplicated. The laparoscopic adrenalectomy for a 2.0-cm right adrenal adenoma resulted in normalizing of her blood pressure and serum potassium level. Although primary aldosteronism is rare, especially during pregnancy, it should be always considered as one of etiologies of hypertension in pregnancy. (+info)

The expression of inhibin/activin subunits in the human adrenal cortex and its tumours. (2/137)

Inhibins and activins are dimeric proteins of the transforming growth factor-beta superfamily which have been shown to be expressed in the adrenal cortex. Recent studies have suggested a role for these peptides in the pathogenesis and/or function of adrenal tumours. To investigate further their physiological and pathological roles, we have documented immunoreactivity for inhibin alpha, betaA and betaB subunits in normal adult and fetal human adrenals, in hyperplastic adrenals and in adrenal tumours. In the normal and hyperplastic adult gland, diffuse immunopositivity was demonstrated for beta subunits, suggesting that activins (beta beta dimers) can be expressed in all zones. Inhibin alpha was limited to the zona reticularis and the innermost zona fasciculata in the normal gland, extending centripetally into the zona fasciculata in hyperplasia, supporting a role for ACTH in the regulation of expression, and suggesting that expression of inhibins (alpha beta dimers) is restricted. Immunopositivity for all three subunits was seen in both fetal and definitive zones of the fetal cortex, indicating that both inhibins and activins could be expressed in both. Immunopositivity for all three subunits was seen in most adrenocortical tumours. Loss of immunopositivity for inhibin alpha in a subgroup of carcinomas might indicate a role in tumour progression. The greater intensity of staining for inhibin alpha in tumours associated with Cushing's syndrome again suggests a link with cortisol production. (+info)

Analysis of genomic alterations in sporadic adrenocortical lesions. Gain of chromosome 17 is an early event in adrenocortical tumorigenesis. (3/137)

Genetic changes underlying the tumorigenesis of sporadic adrenocortical tumors are poorly characterized. To search for characteristic genomic imbalances involved in adrenocortical tumors, we examined 41 adrenocortical lesions (12 carcinomas, 23 adenomas, and 6 hyperplasias) by comparative genomic hybridization. Our results show that genetic alterations are more frequent in malignant than in benign lesions and that they rarely occur in hyperplastic lesions. The most frequent DNA copy number changes in adrenocortical carcinomas included losses of 1p21-31, 2q, 3p, 3q, 6q, 9p, and 11q14-qter, as well as gains and amplifications of 5q12, 9q32-qter, 12q, and 20q. The genomic aberrations prevalently occurring in adrenocortical adenomas were gains of 17q, 17p, and 9q32-qter. Gains found in 2 of 6 adrenocortical hyperplastic lesions involved chromosome 17 or 17q only. These data indicate that oncogenes determining the early tumorigenesis of adrenocortical tumors may exist on chromosome 17 and that the number of genomic alterations is closely associated with tumor behavior in adrenocortical tumors. (+info)

Recurrence of adrenal aldosterone-producing adenoma. (4/137)

Conn's syndrome (adrenal aldosterone-producing adenoma) and bilateral adrenal hyperplasia are the most common causes of primary aldosteronism. The treatment of choice for patients with aldosterone-producing adenoma is unilateral total adrenalectomy. Recurrence after adequate surgery is exceptional. We present a patient with recurrence of an aldosterone-producing adenoma in the right adrenal gland 9 years after adenomectomy of a aldosterone-producing adenoma in the same adrenal gland. We conclude that adenomectomy is not an adequate therapy for patients with adrenal aldosterone-producing adenoma. (+info)

PET imaging of adrenal cortical tumors with the 11beta-hydroxylase tracer 11C-metomidate. (5/137)

The purpose of the study was to evaluate PET with the tracer 11C-metomidate as a method to identify adrenal cortical lesions. METHODS: PET with 11C-metomidate was performed in 15 patients with unilateral adrenal mass confirmed by CT. All patients subsequently underwent surgery, except 2 who underwent biopsy only. The lesions were histopathologically examined and diagnosed as adrenal cortical adenoma (n = 6; 3 nonfunctioning), adrenocortical carcinoma (n = 2), and nodular hyperplasia (n = 1). The remaining were noncortical lesions, including 1 pheochromocytoma, 1 myelolipoma, 2 adrenal cysts, and 2 metastases. RESULTS: All cortical lesions were easily identified because of exceedingly high uptake of 11C-metomidate, whereas the noncortical lesions showed very low uptake. High uptake was also seen in normal adrenal glands and in the stomach. The uptake was intermediate in the liver and low in other abdominal organs. Images obtained immediately after tracer injection displayed high uptake in the renal cortex and spleen. The tracer uptake in the cortical lesions increased throughout the examination. For quantitative evaluation of tracer binding in individual lesions, a model with the splenic radioactivity concentration assigned to represent nonspecific uptake was applied. Values derived with this method, however, did show the same specificity as the simpler standardized uptake value concept, with similar difference observed for cortical versus noncortical lesions. CONCLUSION: PET with 11C-metomidate has the potential to be an attractive method for the characterization of adrenal masses with the ability to discriminate lesions of adrenal cortical origin from noncortical lesions. (+info)

Expression of inhibin alpha in adrenocortical tumours reflects the hormonal status of the neoplasm. (6/137)

Inhibins are gonadal glycoprotein hormones whose main endocrine function is to inhibit pituitary FSH secretion. In addition to testes and ovaries, other steroid-producing organs are sites of inhibin alpha subunit expression. To study the role of inhibins in human adrenal gland, we screened a panel of 150 adrenals (10 normal adrenals, 25 adrenocortical hyperplasias, 65 adrenocortical adenomas, 30 adrenocortical carcinomas and 20 phaeochromocytomas) for inhibin alpha expression. mRNA levels of inhibin alpha subunit were studied in 57 samples and all tissues were stained immunohistochemically with an inhibin alpha subunit-specific antibody. Inhibin alpha mRNA was detected in all adrenocortical tissues. Virilizing adenomas possessed a 10-fold higher median inhibin alpha mRNA expression than did normal adrenals. Bilaterally and nodularly hyperplastic adrenals and other than virilizing adrenocortical tumours had their median inhibin alpha mRNA levels close to those of normal adrenals. Immunohistochemically, inhibin alpha subunit was detectable in all normal and hyperplastic adrenals, as well as in 73% of the adrenocortical tumours. However, the percentage of inhibin alpha-positive cells varied greatly in different tumour types. The median percentage of positive cells was 10 in non-functional and Conn's adenomas, 30 in Cushing's adenomas and 75 in virilizing adenomas. In malignant adrenocortical tumours the median percentage of inhibin alpha-immunopositive cells was 20 in non-functional carcinomas, 30 in Conn's carcinomas, 65 in Cushing's carcinomas and 75 in virilizing carcinomas. All phaeochromocytomas were negative for inhibin alpha subunit both at the mRNA level and immunohistochemically. Our data show that inhibin alpha subunit is highly expressed in both normal and neoplastic androgen-producing adrenocortical cells, with less expression in cortisol-producing and hardly any in aldosterone-producing cells. This suggests a specific role for inhibins in the regulation of adrenal androgen production. We did not find any significant difference in inhibin alpha expression between benign and malignant adrenocortical tumours. Thus inhibin alpha gene does not seem to have a tumour suppressor role in human adrenal cortex. (+info)

Molecular analysis of CDKN1C and TP53 in sporadic adrenal tumors. (7/137)

OBJECTIVE: To evaluate the roles of the CDKN1C (P57KIP2) gene, which encodes for the cyclin-dependent kinase inhibitor CDNC, and the TP53 tumor suppressor gene in adrenal tumorigenesis, as a means of investigating the molecular basis of sporadic adrenal tumors, which is unknown. DESIGN: Screening for the presence CDKN1C and TP53 mutations and analyzing the expression pattern of CDNC, P53 and its downstream effector CDN1 (P21WAF1/CIP1) in a series of 79 sporadic adrenal tumors. METHODS: Single-strand conformation polymorphism and sequencing were used for mutation analysis of CDKN1C and TP53 in blood and adrenal tissue samples. In a subgroup of 48 tissues, CDKN1C expression was evaluated by RT-PCR and immunohistochemistry. Immunohistochemical analysis of P53 and CDN1 was performed. RESULTS: No somatic mutations of CDKN1C were found in the tumors analyzed, in spite of low/absent CDNC expression in adrenocortical adenomas and carcinomas. Mutations in the TP53 gene were present in 70% of adrenocortical carcinomas, associated with abnormal P53 and CDN1 expression, but not in benign neoplasms. In the normal adrenal cortex, CDNC expression was strictly nuclear and confined to the cortical zone (i.e. zona glomerulosa and reticularis), with no staining in the medulla. CONCLUSIONS: Mutations in the TP53 gene are frequent in adrenocortical carcinomas and might be used as a marker of malignancy. In the normal adrenal cortex, the zone-specific pattern of expression of CDNC suggests a role in adrenal differentiation. (+info)

Localization of the endothelin system in aldosterone-producing adenomas. (8/137)

Endothelin-1 (ET-1) could play a role in the regulation of aldosterone secretion of the human adrenal gland. The presence of the endothelin-converting enzyme 1 (ECE-1) and ET-1 suggests that there is a local ET system in the adrenal cortex, but the in situ synthesis of ET-1 remains to be confirmed. The cellular distribution of the whole ET system was evaluated in 20 cases of aldosterone-producing adenomas. Polymerase chain reaction studies gave strong signals for ECE-1 mRNA and the mRNAs for endothelin type A (ET(A)) and B (ET(B)) receptors and faint signals for prepro-ET-1 mRNA. In situ hybridization showed ET(A) receptors scattered throughout the adenoma, in both secretory cells and vascular structures (score, +). There were more ET(B) receptors (score, ++), but they were restricted mainly to the endothelium. ECE-1 mRNA and protein were ubiquitous and abundant in secretory cells (score, +++) and vascular structures (score, ++); the enzyme was active on big ET-1. There was no prepro-ET-1 mRNA in the cortex, except in the thickened precapillary arterioles present in only 30% of the aldosterone-producing adenomas studied. ET-1 immunoreactivity was detected in vascular structures (score, +), probably bound to receptors, suggesting that ET-1 has an endocrine action. The low concentrations of ET-1 could also indicate that it acts in a paracrine-autocrine fashion to control adrenal blood flow. The discrepancy between the concentrations of ECE-1 and its substrate suggests that ECE-1 has another role in the adrenal secretory cells. Our data indicate that ET probably is not a primary cause of the development or maintenance of the adenoma. (+info)

... with focal high grade nuclear atypia Adrenocortical adenoma with focal necrosis Adrenocortical adenomas ... Adrenocortical adenoma 3: Undetermined 4-9: Adrenocortical carcinoma Non-functioning cases of adrenocortical adenoma can be ... Like most adenomas, the adrenocortical adenoma is considered a benign tumor since the majority of them are non-functioning and ... protein kinase A pathways have been implicated in the adrenocortical pathophysiology. If functional, adrenocortical adenomas ...

https://en.wikipedia.org/wiki/Adrenocortical_adenoma

Imaging to detect an Adrenocortical adenoma may also be considered.[citation needed] Aldosterone deficiency should be treated ...

https://en.wikipedia.org/wiki/Hypoaldosteronism

"Primary hyperaldosteronism in a domestic ferret with an adrenocortical adenoma". Journal of the American Veterinary Medical ...

https://en.wikipedia.org/wiki/Leuprorelin

"Expression of CYP11B2 in Aldosterone-Producing Adrenocortical Adenoma: Regulatory Mechanisms and Clinical Significance". The ...

https://en.wikipedia.org/wiki/Aldosterone_synthase

Molecular basics of aldosterone and cortisol synthesis in normal adrenals and adrenocortical adenomas]". Endokrynologia Polska ... Compare these effects to those seen in Conn's disease, an adrenocortical tumor which causes excess release of aldosterone, that ... October 2004). "[Childhood adrenocortical tumors]". Arquivos Brasileiros de Endocrinologia e Metabologia (in Portuguese). 48 (5 ...

https://en.wikipedia.org/wiki/Secondary_hypertension

March 2002). "Cellular localization of orexin receptors in human adrenal gland, adrenocortical adenomas and pheochromocytomas ... "Orexin A stimulates cortisol secretion from human adrenocortical cells through activation of the adenylate cyclase-dependent ...

https://en.wikipedia.org/wiki/Hypocretin_(orexin)_receptor_2

Unilateral primary hyperaldosteronism due to an adrenocortical adenoma or adrenocarcinoma can be potentially cured surgically. ... One type is caused by a unilateral aldosterone-producing adenoma or adenocarcinoma. The other type, known as idiopathic ... Bilateral primary hyperaldosteronism due to hyperplasia of the zona glomerulosa or metastasized adrenocortical adenocarcinoma ...

https://en.wikipedia.org/wiki/Feline_hyperaldosteronism

Mir-210 has been suggested as a useful biomarker to distinguish adrenocortical carcinoma from adrenocortical adenoma. in ... "Analysis of circulating microRNAs in adrenocortical tumors". Laboratory Investigation; A Journal of Technical Methods and ...

https://en.wikipedia.org/wiki/Mir-181_microRNA_precursor

Mir-210 has been suggested as a useful biomarker to distinguish adrenocortical carcinoma from adrenocortical adenoma. mir-210 ... "Analysis of circulating microRNAs in adrenocortical tumors". Laboratory Investigation; A Journal of Technical Methods and ...

https://en.wikipedia.org/wiki/Mir-210_microRNA

Adrenocortical adenoma 3: Undetermined 4-9: Adrenocortical carcinoma The only curative treatment is complete surgical excision ... Adrenocortical adenoma Renal cell carcinoma Pheochromocytoma Hepatocellular carcinoma Adrenocortical carcinomas are most ... The presence of invasion and mitotic activity help differentiate small cancers from adrenocortical adenomas. Several relatively ... such as adrenocortical adenoma, and determining the extent of invasion of the tumor into surrounding organs and tissues. On CT ...

https://en.wikipedia.org/wiki/Adrenocortical_carcinoma

In people with hyperaldosteronism due to unilateral aldosterone-producing adrenocortical adenoma, adrenalectomy should be ...

https://en.wikipedia.org/wiki/Spironolactone

"Characterization of Serotonin4 Receptors in Adrenocortical Aldosterone-Producing Adenomas: In Vivo and in Vitro Studies". ... Ehrhart-Bornstein, M.; Hilbers, U. (1998). "Neuroendocrine Properties of Adrenocortical Cells" (PDF). Hormone and Metabolic ... acts in this location The expression of neuron-specific proteins in the zona glomerulosa cells of human adrenocortical tissues ... which suggests that calcium-channel blockers may directly influence the adrenocortical biosynthesis of aldosterone in vivo. ...

https://en.wikipedia.org/wiki/Zona_glomerulosa

... esophageal leiomyoma and adrenocortical adenoma. The original description employed the then-prevailing terminology of gastric ...

https://en.wikipedia.org/wiki/Carney's_triad

... endocrine tumors such as thyroid adenomas and adrenocortical adenomas may overproduce certain hormones. Many types of benign ... Adenomas of the rectum may be treated with sclerotherapy, in which chemicals are used to shrink blood vessels in order to cut ... Pituitary adenomas can cause elevated levels of hormones such as growth hormone and insulin-like growth factor-1, which cause ... A prominent and well studied example of this phenomenon is the tubular adenoma, a common type of colon polyp which is an ...

https://en.wikipedia.org/wiki/Benign_tumor

March 2002). "Characterization of serotonin(4) receptors in adrenocortical aldosterone-producing adenomas: in vivo and in vitro ... The primary mineralocorticoid, aldosterone, is produced in the adrenocortical zona glomerulosa by the action of the enzyme ... Ehrhart-Bornstein M, Hilbers U (1998). "Neuroendocrine properties of adrenocortical cells". Horm. Metab. Res. 30 (6-7): 436-9. ... Adrenal insufficiency (e.g. due to Addison's disease) Cushing's syndrome Cushing's disease Conn's syndrome Adrenocortical ...

https://en.wikipedia.org/wiki/Adrenal_cortex

Functional adrenocortical adenomas are surgically curable.[citation needed] Most of the adrenocortical adenomas are less than 2 ... They should not be confused with adrenocortical "nodules", which are not true neoplasms. Adrenocortical adenomas are uncommon ... Grossly, adrenocortical adenomas are encapsulated, well-circumscribed, solitary tumors with solid, homogeneous yellow-cut ... Most adrenal pheochromocytomas and all adrenocortical adenomas are benign tumors, which do not metastasize or invade nearby ...

https://en.wikipedia.org/wiki/Adrenal_tumor

... adrenocortical adenomas, and adrenocortical carcinoma, as well as adrenal hyperplasia due to pituitary adenomas (as in ... Radi, Suhaib; Tamilia, Michael (2019-12-30). "Adrenocortical carcinoma: an ominous cause of hirsutism". BMJ Case Reports. 12 ( ... "Sex steroids in androgen-secreting adrenocortical tumors: clinical and hormonal features in comparison with non-tumoral causes ...

https://en.wikipedia.org/wiki/Hirsutism

Other mutations and genetic alterations in the PRKACA gene have been identified in adrenocortical adenomas that also disrupt ...

https://en.wikipedia.org/wiki/PRKACA

"Preproorexin and orexin receptors are expressed in cortisol-secreting adrenocortical adenomas, and orexins stimulate in vitro ... "Orexins stimulate glucocorticoid secretion from cultured rat and human adrenocortical cells, exclusively acting via the OX1 ...

https://en.wikipedia.org/wiki/Hypocretin_(orexin)_receptor_1

... gene selective Alzheimer's disease indicator-1 in the normal adrenal cortex and in adrenocortical adenomas and carcinomas". J. ...

https://en.wikipedia.org/wiki/24-Dehydrocholesterol_reductase

... adrenocortical adenoma MeSH C19.053.347.500.750 - adrenocortical carcinoma MeSH C19.053.500.263 - addison disease MeSH C19.053. ... adrenocortical adenoma MeSH C19.053.098.265.750 - adrenocortical carcinoma MeSH C19.053.347.500 - adrenal cortex neoplasms MeSH ... adrenocortical adenoma MeSH C19.344.078.265.750 - adrenocortical carcinoma MeSH C19.344.400.500 - multiple endocrine neoplasia ... adenoma, islet cell MeSH C19.344.421.249.500 - insulinoma MeSH C19.344.421.500 - carcinoma, islet cell MeSH C19.344.421.500.124 ...

https://en.wikipedia.org/wiki/List_of_MeSH_codes_(C19)

Holmes was familiar with a similar case that had been treated by surgical removal of an adrenocortical adenoma (a tumour of the ...

https://en.wikipedia.org/wiki/Lennox_Broster

Bilateral micronodular hyperplasia is more common than unilateral adrenal adenoma. It can be asymptomatic, but these symptoms ... surgery Bilateral adrenocortical hyperplasia: aldosterone antagonist, e.g., spironolactone Secondary hyperaldosteronism (also ... was previously thought to be most commonly caused by an adrenal adenoma, termed Conn's syndrome. However, recent studies have ... Alkalosis Investigations High serum aldosterone Low serum renin High-resolution CT abdomen Management Adrenal adenoma: ...

https://en.wikipedia.org/wiki/Hyperaldosteronism

... adrenocortical adenoma MeSH C04.588.322.078.265.750 - adrenocortical carcinoma MeSH C04.588.322.400 - multiple endocrine ... adenoma, bile duct MeSH C04.557.470.035.095 - adenoma, chromophobe MeSH C04.557.470.035.100 - adenoma, islet cell MeSH C04.557. ... adenoma MeSH C04.557.470.035.012 - acth-secreting pituitary adenoma MeSH C04.557.470.035.025 - adenoma, acidophil MeSH C04.557. ... adenoma, oxyphilic MeSH C04.557.470.035.155 - adenoma, pleomorphic MeSH C04.557.470.035.175 - adenoma, sweat gland MeSH C04.557 ...

https://en.wikipedia.org/wiki/List_of_MeSH_codes_(C04)

"Adrenocortical Carcinoma". National Cancer Institute. 27 February 2019. "Adenoma of the Adrenal Gland". Genetic and Rare ... In rare cases, however, some adrenal adenomas may become activated. When activated, the adenoma begins to produce hormones in ... Adrenal adenomas are benign tumors of the adrenal gland. In most cases, the tumors display no symptoms and require no treatment ... Adrenocortical carcinoma occurs rarely; the average incidence rate is estimated to be 1-2 cases per million annually. The ...

https://en.wikipedia.org/wiki/Hyperandrogenism

2010) The role of microRNA deregulation in the pathogenesis of adrenocortical carcinoma. Endocr Relat Cancer. (2011) Primary ... primary parathyroid hyperplasia versus adenoma. (2006) Evaluación del impacto funcional e intensidad del dolor antes y después ... 2004) Expression Profiling of Adrenocortical Tumors Suggests a Molecular Signature of Malignancy. (2005) Differential RNA ... 2008) Transcriptional profiling enables molecular classification of adrenocortical tumours. European Journal of Endocrinology ...

https://en.wikipedia.org/wiki/David_Velázquez_Fernández

... tubulovillous adenoma - tumor - tumor antigen vaccine - tumor board review - tumor burden - tumor debulking - tumor ... adrenocortical - Adriamycin - adult T-cell leukemia/lymphoma - AE-941 - AEE788 - aerobic metabolism - aerobic respiration - ... villous adenoma - villus - vinblastine - vinca alkaloid - vincristine - vindesine - vinorelbine - viral vector - virotherapy - ... adenoma - adenopathy - adenosine triphosphate - adenovirus - adjunct agent - adjunctive therapy - adjuvant therapy - ...

https://en.wikipedia.org/wiki/Index_of_oncology_articles

These mutations tend to occur in young women with the adenoma in the cortisol secreting zona fasciculata. Adenomas without this ... of cases Aldosterone-producing adrenocortical carcinoma: < 0.1% of cases 40% of people with an adrenal aldosterone producing ... About 33% of cases are due to an adrenal adenoma that produces aldosterone, and 66% of cases are due to an enlargement of both ... Some cases may be cured by removing the adenoma by surgery after localization with adrenal venous sampling (AVS). A single ...

https://en.wikipedia.org/wiki/Primary_aldosteronism

Adrenal adenoma, a benign tumor of the adrenal gland which may result in overproduction of one or more adrenal hormones, or may ... be inactive Adrenocortical carcinoma, cancer of the adrenal cortex Adrenal incidentaloma, an adrenal tumor (of any type) ...

https://en.wikipedia.org/wiki/Adrenal_gland_disorder

The mean percent methylation of H19 CpGs peaked at sites 9 and 10 in normal, hyperplasia, adenoma and carcinoma adrenals and ... In contrast to most other cancers, adrenocortical neoplasms appear to have decreased expression of H19. To determine a possible ... studied the methylation of 12 CpG sites in the H19 promoter in normal, hyperplasia, adenoma and carcinoma adrenals. They found ... The mean percent CpG methylation at site 11 for hyperplasia and adenoma adrenals is significantly different from that of normal ...

https://en.wikipedia.org/wiki/H19_(gene)

An ACTH-secreting corticotrophic pituitary adenoma should be removed after diagnosis. Regardless of the adenoma's location, ... Fudge EB, von Allmen D, Volmar KE, Calikoglu AS (2009). "Cushing Syndrome in a 6-Month-Old Infant due to Adrenocortical Tumor ... When Cushing's syndrome is caused by an increase of cortisol at the level of the adrenal glands (via an adenoma or hyperplasia ... Cases due to a pituitary adenoma are known as Cushing's disease, which is the second most common cause of Cushing's syndrome ...

https://en.wikipedia.org/wiki/Cushing's_syndrome

544-. ISBN 978-3-642-60107-1. Kovacs K, Stefaneanu L, Ezzat S, Smyth HS (May 1994). "Prolactin-producing pituitary adenoma in a ... "Effect of oestrogen or cyproterone acetate treatment on adrenocortical function in prostate carcinoma patients". Acta ...

https://en.wikipedia.org/wiki/Side_effects_of_cyproterone_acetate

"WNT-4 mRNA expression in human adrenocortical tumors and cultured adrenal cells". Hormone and Metabolic Research. 40 (10): 668- ... "Expression of Wnt4 in human pituitary adenomas regulates activation of the beta-catenin-independent pathway". Endocrine ...

https://en.wikipedia.org/wiki/WNT4

TCF4 Pituitary adenoma, ACTH-secreting; 219090; AIP Pituitary adenoma, growth hormone-secreting; 102200; AIP Pituitary adenoma ... LAMB2 Pigmented adrenocortical disease, primary, 1; 610489; PRKAR1A Pigmented nodular adrenocortical disease, primary, 2; ... PRKN Adenomas, multiple colorectal; 608456; MUTYH Adenomas, salivary gland pleomorphic; 181030; PLAG1 Adenomatous polyposis ... EIF2B4 Leydig cell adenoma, somatic, with precocious puberty; 176410; LHCGR Leydig cell hypoplasia with hypergonadotropic ...

https://en.wikipedia.org/wiki/List_of_OMIM_disorder_codes

Cushing's disease is characterized by the hypersecretion of the adrenocorticotropic hormone (ACTH) due to a pituitary adenoma ... Pohorecky LA, Wurtman RJ (March 1971). "Adrenocortical control of epinephrine synthesis". Pharmacological Reviews. 23 (1): 1-35 ... Endocrine disease is characterized by misregulated hormone release (a productive pituitary adenoma), inappropriate response to ...

https://en.wikipedia.org/wiki/Endocrine_system

... was upregulated in adrenocortical carcinoma and salivary gland cancer, but downregulated in patients with colorectal ... 22 April 2014). "Identification of Unique miRNA Biomarkers in Colorectal Adenoma and Carcinoma Using Microarray: Evaluation of ... Knott EL, Leidenheimer NJ (November 2020). "A Targeted Bioinformatics Assessment of Adrenocortical Carcinoma Reveals Prognostic ... "Role of GABA and glutamate circuitry in hypothalamo-pituitary-adrenocortical stress integration". Annals of the New York ...

https://en.wikipedia.org/wiki/GABRB2

Rarely (5-12%), the adrenal tumor may be cancerous (adrenocortical carcinoma), requiring adrenalectomy. Rarer still, the mass ... After adrenalectomy for a cortisol-producing adenoma, patients should be treated with exogenous glucocorticoids such as ... and in adrenocortical carcinoma where there is a risk of not fully removing the cancerous tissue. However, at least one meta- ...

https://en.wikipedia.org/wiki/Adrenalectomy

Tumors with increased risk in this disorder are colorectal cancer, gastric adenomas and duodenal adenomas. Nevoid basal cell ... Genetic testing should be considered with adrenocortical carcinoma; carcinoid tumors; diffuse gastric cancer; fallopian tube/ ... An individual with this disease will have hundreds to thousands of benign adenomas throughout their colon, which will in most ... Other tumors increased in frequency include; osteomas, adrenal adenomas and carcinomas, thyroid tumors and desmoid tumors. The ...

https://en.wikipedia.org/wiki/Cancer_syndrome

Adenocarcinoma of the lung Bronchial adenomas/carcinoids Small cell lung cancer Mesothelioma Non-small cell lung cancer Non- ... carcinoma Male breast cancer Phyllodes tumor Mammary secretory carcinoma Papillary carcinomas of the breast Adrenocortical ... Cerebral astrocytoma Glioblastoma Glioma Medulloblastoma Neuroblastoma Oligodendroglioma Pineal astrocytoma Pituitary adenoma ...

https://en.wikipedia.org/wiki/List_of_cancer_types

Most people with the disorder have a single adenoma. This form of the syndrome, known as Cushing's disease Forbis P (2005). ... "Response of plasma ACTH and adrenocortical hormones to potassium loading in essential hypertension". Japanese Circulation ...

https://en.wikipedia.org/wiki/Cortisol

Reprinted in Cushing H (April 1969). "The basophil adenomas of the pituitary body". Ann R Coll Surg Engl. 44 (4): 180-1. PMC ... The other hypothesis was that Minnie might have had Primary Pigmented Nodular Adrenocortical Disease (PPNAD), which when ... Pituitary adenomas are responsible for 80% of endogenous Cushing's syndrome, when excluding Cushing's syndrome from exogenously ... Ding D, Starke RM, Sheehan JP (May 2014). "Treatment paradigms for pituitary adenomas: defining the roles of radiosurgery and ...

https://en.wikipedia.org/wiki/Cushing's_disease

Addison's disease - primary adrenocortical insufficiency Cushing's syndrome - overproduction of cortisol Insulin tolerance test ... Principal causes include: Pituitary adenoma or craniopharyngioma: Tumors in the pituitary gland can suppress production of ... pituitary adenoma, craniopharyngioma) which can take up space and interfere with the secretion of pituitary hormones such as ... adenoma (tumor) of the adrenal gland Deposition disease: e.g. hemochromatosis, amyloidosis, sarcoidosis Idiopathic: ...

https://en.wikipedia.org/wiki/Adrenal_insufficiency

... Di ... PATIENTS: We collected fresh-frozen tissues from patients with benign adrenocortical adenomas (n = 48) (nonfunctioning n = 9, ... PATIENTS: We collected fresh-frozen tissues from patients with benign adrenocortical adenomas (n = 48) (nonfunctioning n = 9, ... of this work is to investigate DNA methylation and expression of genes encoding steroidogenic enzymes in benign adrenocortical ...

https://cris.unibo.it/handle/11585/778365

Anam J, Uday K, Shetty P, Moiyadi A, Epari S, Jalali R. Aggressive spinal glioblastoma in a child with adrenocortical adenoma ... Aggressive spinal glioblastoma in a child with adrenocortical adenoma ‑ Case report and review of literature. ...

https://imsear.searo.who.int/handle/123456789/176748?locale=fr

Adrenocortical adenoma and carcinoma: histopathological and molecular comparative analysis. Stojadinovic A, Brennan MF, Hoos A ... Adrenocortical carcinoma. Brennan MF. Brennan MF. CA Cancer J Clin. 1987 Nov-Dec;37(6):348-65. doi: 10.3322/canjclin.37.6.348. ... Adrenocortical carcinoma. Schulick RD, Brennan MF. Schulick RD, et al. Among authors: brennan mf. World J Urol. 1999 Feb;17(1): ... An eleven-year experience with adrenocortical carcinoma. Pommier RF, Brennan MF. Pommier RF, et al. Among authors: brennan mf. ...

https://pubmed.ncbi.nlm.nih.gov/?term=Brennan+MF&cauthor_id=12920217

Unilateral enlargement is more consistent with an adrenal adenoma or adrenocortical carcinoma. ... Somatotroph adenomas take on the character of typical pituitary adenomas. Somatotroph tumors lack true capsules, with the ... Individuals with somatotroph adenomas due to GNAS1 mutations have detectable elevations of GH, insulinlike growth factor 1 (IGF ... CT of the skull (see the image below) may show pituitary adenoma. Pathologic bone findings may be solitary (MFD) or multiple ( ...

https://www.medscape.com/answers/127233-155910/what-are-the-initial-studies-in-the-workup-of-mccune-albright-syndrome-mas

... or primary pigmented adrenocortical disease (PPNAD) and will be discussed here. Adrenocortical adenomas and malignancy are ... Imaging will also help to identify the presence of an adrenal adenoma, as opposed to hyperplasia of the glands. ... ACTH-dependent (secondary) adrenal hyperplasia is most commonly due to an ACTH-secreting pituitary adenoma (Cushings disease) ... Bilateral adrenal hyperplasia associated with an ACTH-secreting pituitary adenoma is also called Cushings disease and will ...

https://www.renalandurologynews.com/home/decision-support-in-medicine/hospital-medicine/adrenal-hyperplasia-2/

Introduction: Adrenocortical tumours comprise frequent adenomas (ACA) and rare highly malignant carcinoma (ACC). Livin/ML-IAP/ ... Other indications for BA are: bilateral adrenocortical adenomas, congenital adrenal hyperplasia and bilateral phaeochromocytoma ... Magmas was found to be over-expressed in human pituitary adenomas. Silencing Magmas in ACTH secreting rat pituitary adenoma ... Real-time shear wave elastography in the evaluation of parathyroid adenomas. Vlad Mihaela , Golu Ioana , Amzar Daniela , Balas ...

https://www.endocrine-abstracts.org/ea/0037/abstracts/eposter-presentations/endocrine-tumours/

adrenocortical adenoma autonomous production of cortisol from one adrenal gland suppresses CRH, ACTH. less stimulation of the ...

https://www.brainscape.com/flashcards/test-36-427-2264031/packs/3729903

An adrenocortical oncocytoma (an oncocytic variant of the adrenal cortical adenoma) is typically well-circumscribed with a ... The differential diagnosis includes neoplasms of adrenal origin (such as adrenal cortical adenoma or adrenocortical oncocytoma ... Adenomas tend to be smaller and homogenous, whereas carcinomas tend to be larger with gross necrosis. Functional tumors are ... Adrenocortical neoplasms are typically well-circumscribed with a widely variable gross appearance from pink to yellow-tan. ...

https://www.cap.org/member-resources/pathology-case-challenge/right-kidney-and-retroperitoneum

start str = Benign adrenal adenoma. sql str = Benign adrenal adenoma. start str = Adrenocortical carcinoma. sql str = ... result sql = Adrenocortical carcinoma. Adrenocortical carcinoma 82. char = T;code = 84. char = h;code = 104. char = y;code = ... See more studies on Benign adrenal adenoma and.... How is this determined? The order of these related concepts is determined by ...

https://science.naturalnews.com/related/Benign_adrenal_adenoma_and_Adrenocortical_carcinoma.html

Adrenocortical adenoma, Adenomatoid tumor, Myelolipoma, Schwannoma. Overview. Adrenal carcinoma or adrenal tumor is an ... Adrenocortical carcinoma. *Gross pathology of adrenocortical carcinomas shows often a large mass (,5 cm in largest diameter), ... "Mechanism of abnormal production of adrenal androgens in patients with adrenocortical adenomas and carcinomas , The Journal of ... Pathologic criterias for adrenocortical carcinoma. *Different pathological criterias for adrenocortical carcinoma are given in ...

https://www.wikidoc.org/index.php/Adrenal_carcinoma

... level may be a useful clinical marker for differential diagnosis between aldosterone-producing adrenocortical adenoma and ...

https://k-ris.keio.ac.jp/html/100001598_en.html

Adrenocortical Adenoma Medicine & Life Sciences 23% * Glandular and Epithelial Neoplasms Medicine & Life Sciences 18% ... 2 adrenal cortical adenomas, and 2 pheochromocytomas. One pheochromocytoma case was identified in association with an ... 2 adrenal cortical adenomas, and 2 pheochromocytomas. One pheochromocytoma case was identified in association with an ... 2 adrenal cortical adenomas, and 2 pheochromocytomas. One pheochromocytoma case was identified in association with an ...

https://mayoclinic.pure.elsevier.com/en/publications/cystic-adrenal-neoplasms

The histologic diagnosis of the resected adrenal tumor was adrenocortical adenoma. Pre- and post-operative serum samples were ... This study is the first to describe and characterize an adrenocortical adenoma that co-secretes glucocorticoids and 11- ... Herein, we report a case of adrenocortical adenoma that caused marked hyperandrogenemia and mild autonomous cortisol secretion ... ACTH-independent production of 11-oxygenated androgens and glucocorticoids in an adrenocortical adenoma ...

https://eje.bioscientifica.com/search?f_0=author&q_0=Yuto+Yamazaki

The differential diagnoses for such a mass are: adrenal metastases adrenal adenoma pheochromocytoma adrenal hemorrhage The ... adrenal adenoma. *pheochromocytoma. *adrenal hemorrhage. The laboratory tests for pheochromocytoma were found to be normal ( ... The histopathological result of this mass was found to be an adrenocortical carcinoma. ... Mohsen S, Adrenocortical carcinoma. Case study, Radiopaedia.org (Accessed on 08 Dec 2022) https://doi.org/10.53347/rID-80134 ...

https://radiopaedia.org/cases/adrenocortical-carcinoma-4?lang=us

Adenomas, Adrenocortical Adrenal Cortical Adenoma Adrenal Cortical Adenomas Adrenocortical Adenomas Conn Adenoma - Narrower ... Adenomas, Conn. Adrenal Cortical Adenoma. Adrenal Cortical Adenomas. Adrenocortical Adenomas. Conn Adenoma. Conn Adenomas. Conn ... Adenoma, Adrenal Cortical. Adenoma, Adrenocortical. Adenoma, Conn. Adenomas, Adrenal Cortical. Adenomas, Adrenocortical. ... Adrenocortical Adenoma Entry term(s). Adenoma, Adrenal Cortical Adenoma, Adrenocortical Adenomas, Adrenal Cortical ...

https://decs.bvsalud.org/en/ths/resource/?id=31681&filter=ths_exact_term&q=ADRENOCORTICAL+ADENOMA