A benign neoplasm of the ADRENAL CORTEX. It is characterized by a well-defined nodular lesion, usually less than 2.5 cm. Most adrenocortical adenomas are nonfunctional. The functional ones are yellow and contain LIPIDS. Depending on the cell type or cortical zone involved, they may produce ALDOSTERONE; HYDROCORTISONE; DEHYDROEPIANDROSTERONE; and/or ANDROSTENEDIONE.
Tumors or cancers of the ADRENAL CORTEX.
A benign epithelial tumor with a glandular organization.
A malignant neoplasm of the ADRENAL CORTEX. Adrenocortical carcinomas are unencapsulated anaplastic (ANAPLASIA) masses sometimes exceeding 20 cm or 200 g. They are more likely to be functional than nonfunctional, and produce ADRENAL CORTEX HORMONES that may result in hypercortisolism (CUSHING SYNDROME); HYPERALDOSTERONISM; and/or VIRILISM.
A condition caused by prolonged exposure to excess levels of cortisol (HYDROCORTISONE) or other GLUCOCORTICOIDS from endogenous or exogenous sources. It is characterized by upper body OBESITY; OSTEOPOROSIS; HYPERTENSION; DIABETES MELLITUS; HIRSUTISM; AMENORRHEA; and excess body fluid. Endogenous Cushing syndrome or spontaneous hypercortisolism is divided into two groups, those due to an excess of ADRENOCORTICOTROPIN and those that are ACTH-independent.
The outer layer of the adrenal gland. It is derived from MESODERM and comprised of three zones (outer ZONA GLOMERULOSA, middle ZONA FASCICULATA, and inner ZONA RETICULARIS) with each producing various steroids preferentially, such as ALDOSTERONE; HYDROCORTISONE; DEHYDROEPIANDROSTERONE; and ANDROSTENEDIONE. Adrenal cortex function is regulated by pituitary ADRENOCORTICOTROPIN.
A group of hydroxycorticosteroids bearing a hydroxy group at the 17-position. Urinary excretion of these compounds is used as an index of adrenal function. They are used systemically in the free alcohol form, but with esterification of the hydroxy groups, topical effectiveness is increased.
Pathological processes of the ADRENAL CORTEX.
Excision of one or both adrenal glands. (From Dorland, 28th ed)
Tumors or cancer of the ADRENAL GLANDS.
A condition caused by the overproduction of ALDOSTERONE. It is characterized by sodium retention and potassium excretion with resultant HYPERTENSION and HYPOKALEMIA.
The main glucocorticoid secreted by the ADRENAL CORTEX. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions.
An anterior pituitary hormone that stimulates the ADRENAL CORTEX and its production of CORTICOSTEROIDS. ACTH is a 39-amino acid polypeptide of which the N-terminal 24-amino acid segment is identical in all species and contains the adrenocorticotrophic activity. Upon further tissue-specific processing, ACTH can yield ALPHA-MSH and corticotrophin-like intermediate lobe peptide (CLIP).
A pair of glands located at the cranial pole of each of the two KIDNEYS. Each adrenal gland is composed of two distinct endocrine tissues with separate embryonic origins, the ADRENAL CORTEX producing STEROIDS and the ADRENAL MEDULLA producing NEUROTRANSMITTERS.
Examinations that evaluate and monitor hormone production in the adrenal cortex.
An enzyme that catalyzes the reduction of a 3 beta-hydroxy-delta(5)-steroid to 3-oxo-delta(4)-steroid in the presence of NAD. It converts pregnenolone to progesterone and dehydroepiandrosterone to androstenedione. EC 1.1.1.145.
A microsomal cytochrome P450 enzyme that catalyzes the 17-alpha-hydroxylation of progesterone or pregnenolone and subsequent cleavage of the residual two carbons at C17 in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP17 gene, generates precursors for glucocorticoid, androgen, and estrogen synthesis. Defects in CYP17 gene cause congenital adrenal hyperplasia (ADRENAL HYPERPLASIA, CONGENITAL) and abnormal sexual differentiation.
A hormone secreted by the ADRENAL CORTEX that regulates electrolyte and water balance by increasing the renal retention of sodium and the excretion of potassium.
Unanticipated information discovered in the course of testing or medical care. Used in discussions of information that may have social or psychological consequences, such as when it is learned that a child's biological father is someone other than the putative father, or that a person tested for one disease or disorder has, or is at risk for, something else.
A derivative of the insecticide DICHLORODIPHENYLDICHLOROETHANE that specifically inhibits cells of the adrenal cortex and their production of hormones. It is used to treat adrenocortical tumors and causes CNS damage, but no bone marrow depression.
A usually benign, well-encapsulated, lobular, vascular tumor of chromaffin tissue of the ADRENAL MEDULLA or sympathetic paraganglia. The cardinal symptom, reflecting the increased secretion of EPINEPHRINE and NOREPINEPHRINE, is HYPERTENSION, which may be persistent or intermittent. During severe attacks, there may be HEADACHE; SWEATING, palpitation, apprehension, TREMOR; PALLOR or FLUSHING of the face, NAUSEA and VOMITING, pain in the CHEST and ABDOMEN, and paresthesias of the extremities. The incidence of malignancy is as low as 5% but the pathologic distinction between benign and malignant pheochromocytomas is not clear. (Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1298)
Excess production of ADRENAL CORTEX HORMONES such as ALDOSTERONE; HYDROCORTISONE; DEHYDROEPIANDROSTERONE; and/or ANDROSTENEDIONE. Hyperadrenal syndromes include CUSHING SYNDROME; HYPERALDOSTERONISM; and VIRILISM.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
An anti-inflammatory 9-fluoro-glucocorticoid.
A benign, slow-growing tumor, most commonly of the salivary gland, occurring as a small, painless, firm nodule, usually of the parotid gland, but also found in any major or accessory salivary gland anywhere in the oral cavity. It is most often seen in women in the fifth decade. Histologically, the tumor presents a variety of cells: cuboidal, columnar, and squamous cells, showing all forms of epithelial growth. (Dorland, 27th ed)
An adenoma of the large intestine. It is usually a solitary, sessile, often large, tumor of colonic mucosa composed of mucinous epithelium covering delicate vascular projections. Hypersecretion and malignant changes occur frequently. (Stedman, 25th ed)
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
Neoplasms which arise from or metastasize to the PITUITARY GLAND. The majority of pituitary neoplasms are adenomas, which are divided into non-secreting and secreting forms. Hormone producing forms are further classified by the type of hormone they secrete. Pituitary adenomas may also be characterized by their staining properties (see ADENOMA, BASOPHIL; ADENOMA, ACIDOPHIL; and ADENOMA, CHROMOPHOBE). Pituitary tumors may compress adjacent structures, including the HYPOTHALAMUS, several CRANIAL NERVES, and the OPTIC CHIASM. Chiasmal compression may result in bitemporal HEMIANOPSIA.
A benign epithelial tumor of the LIVER.
A mitochondrial cytochrome P450 enzyme that catalyzes the 11-beta-hydroxylation of steroids in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP11B1 gene, is important in the synthesis of CORTICOSTERONE and HYDROCORTISONE. Defects in CYP11B1 cause congenital adrenal hyperplasia (ADRENAL HYPERPLASIA, CONGENITAL).
A synthetic peptide that is identical to the 24-amino acid segment at the N-terminal of ADRENOCORTICOTROPIC HORMONE. ACTH (1-24), a segment similar in all species, contains the biological activity that stimulates production of CORTICOSTEROIDS in the ADRENAL CORTEX.
The wide middle zone of the adrenal cortex. This zone produces a series of enzymes that convert PREGNENOLONE to cortisol (HYDROCORTISONE) via 17-ALPHA-HYDROXYPROGESTERONE.
Conditions in which the production of adrenal CORTICOSTEROIDS falls below the requirement of the body. Adrenal insufficiency can be caused by defects in the ADRENAL GLANDS, the PITUITARY GLAND, or the HYPOTHALAMUS.
A mitochondrial cytochrome P450 enzyme that catalyzes the 18-hydroxylation of steroids in the presence of molecular oxygen and NADPH-specific flavoprotein. This enzyme, encoded by CYP11B2 gene, is important in the conversion of CORTICOSTERONE to 18-hydroxycorticosterone and the subsequent conversion to ALDOSTERONE.
The profession of writing. Also the identity of the writer as the creator of a literary production.
An autosomal dominant familial disorder characterized by recurrent episodes of skeletal muscle weakness associated with falls in serum potassium levels. The condition usually presents in the first or second decade of life with attacks of trunk and leg paresis during sleep or shortly after awakening. Symptoms may persist for hours to days and generally are precipitated by exercise or a meal high in carbohydrates. (Adams et al., Principles of Neurology, 6th ed, p1483)
A complication of PREGNANCY, characterized by a complex of symptoms including maternal HYPERTENSION and PROTEINURIA with or without pathological EDEMA. Symptoms may range between mild and severe. Pre-eclampsia usually occurs after the 20th week of gestation, but may develop before this time in the presence of trophoblastic disease.
Specific enzyme subunits that form the active sites of the type I and type II cyclic-AMP protein kinases. Each molecule of enzyme contains two catalytic subunits.
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
A naturally occurring glucocorticoid. It has been used in replacement therapy for adrenal insufficiency and as an anti-inflammatory agent. Cortisone itself is inactive. It is converted in the liver to the active metabolite HYDROCORTISONE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p726)
A disease of the PITUITARY GLAND characterized by the excess amount of ADRENOCORTICOTROPIC HORMONE secreted. This leads to hypersecretion of cortisol (HYDROCORTISONE) by the ADRENAL GLANDS resulting in CUSHING SYNDROME.
The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.
Pathological processes involving the THYROID GLAND.

Primary aldosteronism with aldosterone-producing adrenal adenoma in a pregnant woman. (1/137)

A 30-year-old pregnant woman complained of muscle weakness at 29 weeks' gestation. She was hypertensive with severe hypokalemia. Lower plasma renin activity and higher aldosterone level than the normal values in pregnancy suggested primary aldosteronism. A cesarean delivery was performed at 31 weeks' gestation because of pulmonary congestion. The neonatal course was uncomplicated. The laparoscopic adrenalectomy for a 2.0-cm right adrenal adenoma resulted in normalizing of her blood pressure and serum potassium level. Although primary aldosteronism is rare, especially during pregnancy, it should be always considered as one of etiologies of hypertension in pregnancy.  (+info)

The expression of inhibin/activin subunits in the human adrenal cortex and its tumours. (2/137)

Inhibins and activins are dimeric proteins of the transforming growth factor-beta superfamily which have been shown to be expressed in the adrenal cortex. Recent studies have suggested a role for these peptides in the pathogenesis and/or function of adrenal tumours. To investigate further their physiological and pathological roles, we have documented immunoreactivity for inhibin alpha, betaA and betaB subunits in normal adult and fetal human adrenals, in hyperplastic adrenals and in adrenal tumours. In the normal and hyperplastic adult gland, diffuse immunopositivity was demonstrated for beta subunits, suggesting that activins (beta beta dimers) can be expressed in all zones. Inhibin alpha was limited to the zona reticularis and the innermost zona fasciculata in the normal gland, extending centripetally into the zona fasciculata in hyperplasia, supporting a role for ACTH in the regulation of expression, and suggesting that expression of inhibins (alpha beta dimers) is restricted. Immunopositivity for all three subunits was seen in both fetal and definitive zones of the fetal cortex, indicating that both inhibins and activins could be expressed in both. Immunopositivity for all three subunits was seen in most adrenocortical tumours. Loss of immunopositivity for inhibin alpha in a subgroup of carcinomas might indicate a role in tumour progression. The greater intensity of staining for inhibin alpha in tumours associated with Cushing's syndrome again suggests a link with cortisol production.  (+info)

Analysis of genomic alterations in sporadic adrenocortical lesions. Gain of chromosome 17 is an early event in adrenocortical tumorigenesis. (3/137)

Genetic changes underlying the tumorigenesis of sporadic adrenocortical tumors are poorly characterized. To search for characteristic genomic imbalances involved in adrenocortical tumors, we examined 41 adrenocortical lesions (12 carcinomas, 23 adenomas, and 6 hyperplasias) by comparative genomic hybridization. Our results show that genetic alterations are more frequent in malignant than in benign lesions and that they rarely occur in hyperplastic lesions. The most frequent DNA copy number changes in adrenocortical carcinomas included losses of 1p21-31, 2q, 3p, 3q, 6q, 9p, and 11q14-qter, as well as gains and amplifications of 5q12, 9q32-qter, 12q, and 20q. The genomic aberrations prevalently occurring in adrenocortical adenomas were gains of 17q, 17p, and 9q32-qter. Gains found in 2 of 6 adrenocortical hyperplastic lesions involved chromosome 17 or 17q only. These data indicate that oncogenes determining the early tumorigenesis of adrenocortical tumors may exist on chromosome 17 and that the number of genomic alterations is closely associated with tumor behavior in adrenocortical tumors.  (+info)

Recurrence of adrenal aldosterone-producing adenoma. (4/137)

Conn's syndrome (adrenal aldosterone-producing adenoma) and bilateral adrenal hyperplasia are the most common causes of primary aldosteronism. The treatment of choice for patients with aldosterone-producing adenoma is unilateral total adrenalectomy. Recurrence after adequate surgery is exceptional. We present a patient with recurrence of an aldosterone-producing adenoma in the right adrenal gland 9 years after adenomectomy of a aldosterone-producing adenoma in the same adrenal gland. We conclude that adenomectomy is not an adequate therapy for patients with adrenal aldosterone-producing adenoma.  (+info)

PET imaging of adrenal cortical tumors with the 11beta-hydroxylase tracer 11C-metomidate. (5/137)

The purpose of the study was to evaluate PET with the tracer 11C-metomidate as a method to identify adrenal cortical lesions. METHODS: PET with 11C-metomidate was performed in 15 patients with unilateral adrenal mass confirmed by CT. All patients subsequently underwent surgery, except 2 who underwent biopsy only. The lesions were histopathologically examined and diagnosed as adrenal cortical adenoma (n = 6; 3 nonfunctioning), adrenocortical carcinoma (n = 2), and nodular hyperplasia (n = 1). The remaining were noncortical lesions, including 1 pheochromocytoma, 1 myelolipoma, 2 adrenal cysts, and 2 metastases. RESULTS: All cortical lesions were easily identified because of exceedingly high uptake of 11C-metomidate, whereas the noncortical lesions showed very low uptake. High uptake was also seen in normal adrenal glands and in the stomach. The uptake was intermediate in the liver and low in other abdominal organs. Images obtained immediately after tracer injection displayed high uptake in the renal cortex and spleen. The tracer uptake in the cortical lesions increased throughout the examination. For quantitative evaluation of tracer binding in individual lesions, a model with the splenic radioactivity concentration assigned to represent nonspecific uptake was applied. Values derived with this method, however, did show the same specificity as the simpler standardized uptake value concept, with similar difference observed for cortical versus noncortical lesions. CONCLUSION: PET with 11C-metomidate has the potential to be an attractive method for the characterization of adrenal masses with the ability to discriminate lesions of adrenal cortical origin from noncortical lesions.  (+info)

Expression of inhibin alpha in adrenocortical tumours reflects the hormonal status of the neoplasm. (6/137)

Inhibins are gonadal glycoprotein hormones whose main endocrine function is to inhibit pituitary FSH secretion. In addition to testes and ovaries, other steroid-producing organs are sites of inhibin alpha subunit expression. To study the role of inhibins in human adrenal gland, we screened a panel of 150 adrenals (10 normal adrenals, 25 adrenocortical hyperplasias, 65 adrenocortical adenomas, 30 adrenocortical carcinomas and 20 phaeochromocytomas) for inhibin alpha expression. mRNA levels of inhibin alpha subunit were studied in 57 samples and all tissues were stained immunohistochemically with an inhibin alpha subunit-specific antibody. Inhibin alpha mRNA was detected in all adrenocortical tissues. Virilizing adenomas possessed a 10-fold higher median inhibin alpha mRNA expression than did normal adrenals. Bilaterally and nodularly hyperplastic adrenals and other than virilizing adrenocortical tumours had their median inhibin alpha mRNA levels close to those of normal adrenals. Immunohistochemically, inhibin alpha subunit was detectable in all normal and hyperplastic adrenals, as well as in 73% of the adrenocortical tumours. However, the percentage of inhibin alpha-positive cells varied greatly in different tumour types. The median percentage of positive cells was 10 in non-functional and Conn's adenomas, 30 in Cushing's adenomas and 75 in virilizing adenomas. In malignant adrenocortical tumours the median percentage of inhibin alpha-immunopositive cells was 20 in non-functional carcinomas, 30 in Conn's carcinomas, 65 in Cushing's carcinomas and 75 in virilizing carcinomas. All phaeochromocytomas were negative for inhibin alpha subunit both at the mRNA level and immunohistochemically. Our data show that inhibin alpha subunit is highly expressed in both normal and neoplastic androgen-producing adrenocortical cells, with less expression in cortisol-producing and hardly any in aldosterone-producing cells. This suggests a specific role for inhibins in the regulation of adrenal androgen production. We did not find any significant difference in inhibin alpha expression between benign and malignant adrenocortical tumours. Thus inhibin alpha gene does not seem to have a tumour suppressor role in human adrenal cortex.  (+info)

Molecular analysis of CDKN1C and TP53 in sporadic adrenal tumors. (7/137)

OBJECTIVE: To evaluate the roles of the CDKN1C (P57KIP2) gene, which encodes for the cyclin-dependent kinase inhibitor CDNC, and the TP53 tumor suppressor gene in adrenal tumorigenesis, as a means of investigating the molecular basis of sporadic adrenal tumors, which is unknown. DESIGN: Screening for the presence CDKN1C and TP53 mutations and analyzing the expression pattern of CDNC, P53 and its downstream effector CDN1 (P21WAF1/CIP1) in a series of 79 sporadic adrenal tumors. METHODS: Single-strand conformation polymorphism and sequencing were used for mutation analysis of CDKN1C and TP53 in blood and adrenal tissue samples. In a subgroup of 48 tissues, CDKN1C expression was evaluated by RT-PCR and immunohistochemistry. Immunohistochemical analysis of P53 and CDN1 was performed. RESULTS: No somatic mutations of CDKN1C were found in the tumors analyzed, in spite of low/absent CDNC expression in adrenocortical adenomas and carcinomas. Mutations in the TP53 gene were present in 70% of adrenocortical carcinomas, associated with abnormal P53 and CDN1 expression, but not in benign neoplasms. In the normal adrenal cortex, CDNC expression was strictly nuclear and confined to the cortical zone (i.e. zona glomerulosa and reticularis), with no staining in the medulla. CONCLUSIONS: Mutations in the TP53 gene are frequent in adrenocortical carcinomas and might be used as a marker of malignancy. In the normal adrenal cortex, the zone-specific pattern of expression of CDNC suggests a role in adrenal differentiation.  (+info)

Localization of the endothelin system in aldosterone-producing adenomas. (8/137)

Endothelin-1 (ET-1) could play a role in the regulation of aldosterone secretion of the human adrenal gland. The presence of the endothelin-converting enzyme 1 (ECE-1) and ET-1 suggests that there is a local ET system in the adrenal cortex, but the in situ synthesis of ET-1 remains to be confirmed. The cellular distribution of the whole ET system was evaluated in 20 cases of aldosterone-producing adenomas. Polymerase chain reaction studies gave strong signals for ECE-1 mRNA and the mRNAs for endothelin type A (ET(A)) and B (ET(B)) receptors and faint signals for prepro-ET-1 mRNA. In situ hybridization showed ET(A) receptors scattered throughout the adenoma, in both secretory cells and vascular structures (score, +). There were more ET(B) receptors (score, ++), but they were restricted mainly to the endothelium. ECE-1 mRNA and protein were ubiquitous and abundant in secretory cells (score, +++) and vascular structures (score, ++); the enzyme was active on big ET-1. There was no prepro-ET-1 mRNA in the cortex, except in the thickened precapillary arterioles present in only 30% of the aldosterone-producing adenomas studied. ET-1 immunoreactivity was detected in vascular structures (score, +), probably bound to receptors, suggesting that ET-1 has an endocrine action. The low concentrations of ET-1 could also indicate that it acts in a paracrine-autocrine fashion to control adrenal blood flow. The discrepancy between the concentrations of ECE-1 and its substrate suggests that ECE-1 has another role in the adrenal secretory cells. Our data indicate that ET probably is not a primary cause of the development or maintenance of the adenoma.  (+info)

TY - JOUR. T1 - Primary aldosteronism with bilateral multiple aldosterone-producing adrenal adenomas. AU - Matsuda, Akira. AU - Beniko, Mutsuo. AU - Ikota, Akemi. AU - Yamazaki, Masao. AU - Koizumi, Shigeki. AU - Mizumoto, Hiroaki. AU - Watanabe, Takeo. AU - Matsuya, Kumiko. AU - Kunita, Haruhiko. AU - Mashio, Yasuo. AU - Sasano, Hironobu. N1 - Copyright: Copyright 2017 Elsevier B.V., All rights reserved.. PY - 1996/12. Y1 - 1996/12. N2 - A 41-year-old woman developed primary aldosteronism due to bilateral multiple aldosterone-producing adenomas (APA), She was suspected to have idiopathic hyperaldosferonism (IHA) 7 years previously. Although preoperative data suggested APA and IHA was suspected in a postoperative microscopic specimen, a definite clinical diagnosis could not be made. Cytochrome P-450 and other enzymes involved in aldosterone synthesis were found in the tumor portions but not in the zona glomerulosa of attached adrenals, which histopathologically showed paradoxical hyperplasia. ...
Objective: To test the sensitivity, specificity, accuracy, positive predictive value (PPV) and negative predictive value (NPV) of CT/MR imaging and adrenal vein sampling (AVS) for diagnosis of aldosterone-producing adrenal adenoma (APA).. Material and method: Retrospective study of 14 patients with primary hyperaldosteronism (PAL) who underwent both CT/MR imaging and AVS between June 2007 and June 2012 were performed. The study included 7 male and 7 female patients. Review CT/MR findings of these cases and compared with AVS results were done.. Results: Five of fourteen patients (35%) had unilateral adrenal nodules on CT, and one of fourteen patients (7.1%) had bilateral adrenal nodules on CT[D1]. The remaining eight patients had no significant nodules in both adrenal glands. Among 5 patients who had unilateral adrenal nodule detected from CT, 4 patients (80%) with nodule greater than 10 mm also presented with lateralization from AVS and finally pathological proven APA. The last patient with ...
Hypertension and albuminuria appeared in a pregnant woman simulating pre-eclamptic toxaemia. Hypertension persisted postpartum and periodic paralyses developed.
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Discussion: Adrenal cortical adenomas and carcinomas are rare tumors but with the use of high resolution imaging, such as CT and MRI, incidentally discovered adrenal masses have become a common finding. The diagnostic evaluation of incidental adrenal lesions includes imaging modalities such as CT with and without contrast, MRI and PET, hormonal evaluation, and FNA in certain clinical settings, particularly to exclude metastasis. In up to 20% of cases, these incidental lesions may cause abnormal hormone secretion without obvious clinical manifestations, while nonfunctioning incidental adrenal lesions less than 5 cm are likely to be benign. Distinguishing an adrenal cortical adenoma from carcinoma is a well-known diagnostic challenge in surgical pathology, and thus, in fine needle aspiration cytology. Proposed criteria correlating with subsequent malignant behavior include the combination of three or more of the following: high nuclear grade, greater than 5 mitoses per 50 high-power fields, ...
Exome sequencing was performed for paired tumor/normal samples from patients with corticotropin-independnet Cushings syndrome. Tumor DNA was extracted from adrenocortical adenomas and normal DNA was extracted from adjacent adrenal tissues or periphral blood ...
Ghose and colleagues (1) showed that long-term medical management (5 to 17 years) is a reasonable option for aldosterone-producing adenomas diagnosed by standard biochemistry and computed tomography in terms of blood pressure control and normalization of serum potassium levels in patients who decline or are unfit for surgery. However, I have concerns about the diagnostic accuracy in their cohort of patients. The use of computed tomography alone without adrenal venous sampling is often inadequate in differentiating between aldosterone-producing adenomas and adrenocortical hyperplasia (2, 3), the two major causes of primary hyperaldosteronism. In a series of hypertensive patients with primary hyperaldosteronism, computed tomography alone had a low specificity (58%) and a positive predictive value of only 72% (4). With the additional use of adrenal venous sampling, a significant proportion of patients was found to have nonfunctional adrenal masses with coexisting adrenal hyperplasia (4) ...
A benign Neoplasm of the Adrenal Cortex. It is characterized by a well-defined nodular lesion, usually less than 2.5 cm. Most adrenocortical Adenomas are nonfunctional. The functional ones are yellow and contain Lipids. Depending on the Cell type or cortical zone involved, they may produce Aldosterone; Hydrocortisone; Dehydroepiandrosterone; and/or Androstenedione ...
Somatic mutations in protein kinase A catalytic α subunit (PRKACA) were found to be causative for 30-40% of cortisol-producing adenomas (CPA) of the adrenal gland, rendering PKA signalling constitutively active. In its resting state, PKA is a stable and inactive heterotetramer, consisting of two catalytic and two regulatory subunits with the latter inhibiting PKA activity. The human genome encodes three different PKA catalytic subunits and four different regulatory subunits that are preferentially expressed in different organs. In normal adrenal glands all regulatory subunits are expressed, while CPA exhibit reduced protein levels of the regulatory subunit IIβ. In this study, we linked for the first time the loss of RIIβ protein levels to the PRKACA mutation status and found the down-regulation of RIIβ to arise post-transcriptionally. We further found the PKA subunit expression pattern of different tumours is also present in the zones of the normal adrenal cortex and demonstrate that the different
definition of APA, what does APA mean?, meaning of APA, Aldosterone-Producing Adenoma, APA stands for Aldosterone-Producing Adenoma
TY - JOUR. T1 - Effect of KCNJ5 mutations on gene expression in aldosterone-producing adenomas and adrenocortical cells. AU - Monticone, Silvia. AU - Hattangady, Namita G.. AU - Nishimoto, Koshiro. AU - Mantero, Franco. AU - Rubin, Beatrice. AU - Cicala, Maria Verena. AU - Pezzani, Raffaele. AU - Auchus, Richard J.. AU - Ghayee, Hans K.. AU - Shibata, Hirotaka. AU - Kurihara, Isao. AU - Williams, Tracy A.. AU - Giri, Judith G.. AU - Bollag, Roni J.. AU - Edwards, Michael A.. AU - Isales, Carlos M.. AU - Rainey, William E.. PY - 2012/8/1. Y1 - 2012/8/1. N2 - Context: Primary aldosteronism is a heterogeneous disease that includes both sporadic and familial forms. A point mutation in the KCNJ5 gene is responsible for familial hyperaldosteronism type III. Somatic mutations in KCNJ5 also occur in sporadic aldosterone producing adenomas (APA). Objective: The objective of the study was to define the effect of the KCNJ5 mutations on gene expression and aldosterone production using APA tissue and human ...
Three patients with primary aldosteronism due to adrenocortical carcinoma were studied, two with hyperaldosteronism alone and one also with hypercortisolism; in the later stages all three had hypersecretion of glucocorticoid and androgenic hormones. Although clinical presentations were similar to those of patients with benign adenoma, all had significantly higher concentrations of deoxycorticosterone and aldosterone and more profound hypokalemia. Stimulation with adrenocorticotropin in two patients showed a good cortisol response but no aldosterone response. The circadian rhythm for Cortisol was normal but absent for aldosterone and deoxycorticosterone. Sequential 24-hour circadian studies in one patient showed that as the disease progressed, corticosterone and finally Cortisol lost their circadian rhythms. Treatment with spironolactone, mitotane, or aminoglutethimide had transient clinical effects. The patients died 2 to 13 years later. ...
The adrenal glands are the major source in the body of the steroid hormones. In normal physiology, the pituitary hormone ACTH regulates the secretion of glucocorticoids, while the secretion of mineralocorticoids such as aldosterone is controlled by the renin-angiotensin system. In addition to these two classes of steroids, the adrenal gland secretes lesser amounts of intermediate metabolites as well as dehydroepiandrosterone (DHEA) and its sulfated product (DHEAS) and androstenedione, testosterone, estrogen, and estrone. Dysregulated secretion of any of these hormones can be caused by sporadic adrenocortical adenomas or carcinomas, with the development of specific clinical syndromes depending on the identity of the hormones secreted. In at least a subset of cortisol-producing adrenocortical neoplasms, the presence of ectopic or abnormal receptors has been described, resulting in the regulation of cortisol and/or aldosterone by non-physiologic stimuli. The present study will serve as a mechanism ...
The adrenal glands are the major source in the body of the steroid hormones. In normal physiology, the pituitary hormone ACTH regulates the secretion of glucocorticoids, while the secretion of mineralocorticoids such as aldosterone is controlled by the renin-angiotensin system. In addition to these two classes of steroids, the adrenal gland secretes lesser amounts of intermediate metabolites as well as dehydroepiandrosterone (DHEA) and its sulfated product (DHEAS) and androstenedione, testosterone, estrogen, and estrone. Dysregulated secretion of any of these hormones can be caused by sporadic adrenocortical adenomas or carcinomas, with the development of specific clinical syndromes depending on the identity of the hormones secreted. In at least a subset of cortisol-producing adrenocortical neoplasms, the presence of ectopic or abnormal receptors has been described, resulting in the regulation of cortisol and/or aldosterone by non-physiologic stimuli. The present study will serve as a mechanism ...
Aldosterone-producing adenomas (APAs) cause a sporadic form of primary aldosteronism and somatic mutations in the KCNJ5 gene, which encodes the G-protein-activated inward rectifier K+ channel 4, GIRK4, account for ≈40% of APAs. Additional somatic APA mutations were identified recently in 2 other genes, ATP1A1 and ATP2B3, encoding Na+/K+-ATPase 1 and Ca2+-ATPase 3, respectively, at a combined prevalence of 6.8%. We have screened 112 APAs for mutations in known hotspots for genetic alterations associated with primary aldosteronism. Somatic mutations in ATP1A1, ATP2B3, and KCNJ5 were present in 6.3%, 0.9%, and 39.3% of APAs, respectively, and included 2 novel mutations (Na+/K+-ATPase p.Gly99Arg and GIRK4 p.Trp126Arg). CYP11B2 gene expression was higher in APAs harboring ATP1A1 and ATP2B3 mutations compared with those without these or KCNJ5 mutations. Overexpression of Na+/K+-ATPase p.Gly99Arg and GIRK4 p.Trp126Arg in HAC15 adrenal cells resulted in upregulation of CYP11B2 gene expression and its ...
Adrenal adenomas are the most common adrenal mass lesion and are often found incidentally during abdominal imaging for other reasons. In all cases, but especially in the setting of known current or previous malignancy, adrenal adenomas need to be...
Read Correlation between Lateralization Index of Adrenal Venous Sampling and Standardized Outcome in Primary Aldosteronism, Journal of the Endocrine Society on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
Dec.09-admitted to ER, severe abdominal pain, cause unknown, thought to be apendix, it was not, however, during the ct scan,a 12mm left adrenal adenoma was found, was told to follow up w/ dr.-a week later my primary dr reffered me to an endocrinologist,who ordered blood and urine tests, which i am troubled by, not by the dr, but by the lab tech who took my 24 urine & blood, not knowing the names of the tests ordered, which tubes to use, etc..., also, when my lab results did come in, they all state fasting as NO, when in fact I did fast, when I mentioned this and the lab tech to the endo. he became defensive, even tho i stated no professional disrespect toward him, but wanted him to know my reservations, and i never did get an anser if fasting no instead of yes was a point of concern ...
Adrenal adenomas are nodules that develop on the adrenal glands. They are common, and they usually dont pose a health threat or require treatment.
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Mouse monoclonal antibody raised against a partial recombinant TARBP2. TARBP2 (NP_599150, 141 a.a. ~ 250 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. (H00006895-M04) - Products - Abnova
BACKGROUND: CD44 is a cell surface glycoprotein found on many normal cells, mainly lymphoid and epithelial. Normal cells usually express standard CD44 (CD44-S), whereas malignant tumours may express CD44 variant isoforms (CD44-V). CD44 expression has been described for neural crest derivatives. Characterisation of differences in CD44 expression may help in the diagnosis and differentiation of distinct adrenal tumours. AIMS: To examine CD44 expression in different layers of cortical cortex, in adrenal medulla, and in adrenal tumours. METHODS: CD44-S and CD44-V6 expression were studied in 12 cases of adrenal cortical adenoma, 3 of adrenal cortical carcinoma, 10 of pheochromocytoma, and 4 normal adrenal glands. RESULTS: CD44-V6 staining showed cytoplasmic expression in normal adrenal cortex and in cortical adenomas and carcinomas. Pheochromocytomas also showed CD44-V6 expression but in 5 of the 10 cases it was sparse, focal, and sometimes perinuclear. Strong membranous staining for CD44-S was ...
BACKGROUND: Cosyntropin and metoclopramide can affect the subtyping of primary aldosteronism when used with adrenal vein sampling by exerting hormone- and side-specific effects on cortisol and aldosterone secretion. We investigated how these stimuli affect the selectivity index, the relative aldosterone secretion index, and the lateralization index in consecutive primary aldosteronism patients submitted to adrenal vein sampling. METHODS: We recruited 171 patients; of these, 149 underwent adrenal vein sampling before and after stimulation with cosyntropin (250 µg intravenous bolus, n= 53, 73% with an aldosterone-producing adenoma) or with metoclopramide (10 mg intravenous bolus, n= 96, 65% aldosterone-producing adenoma), and 32 with an aldosterone-producing adenoma were investigated for the relative gene expression of dopamine, melanocortin 2, and 5-hydroxytryptamine (serotonin) 4 receptor with microarrays ...
Exacerbation of autoimmune thyroid dysfunction after unilateral adrenalectomy in patients with Cushings syndrome due to an adrenocortical adenoma
Adrenocortical carcinoma is an unusual tumor that tends to be larger than 100 g at diagnosis. Malignant adrenocortical tumors of less than 50 g have been reported rarely. We studied a small adrenocortical carcinoma that weighed 40 g and metastasized 3 1/2 years following bilateral adrenalectomy. The malignancy of adrenocortical tumors is frequently difficult to determine. Two recent studies have proposed histologic criteria for determining the malignancy of adrenal cortical tumors. Since the tumor we studied was initially judged to be benign, we sought to determine whether an extensive evaluation of this tumor using these recent criteria could have identified the tumors potential for metastasizing ...
TY - JOUR. T1 - The possible role of apoptosis-suppressing genes, bcl-2 and mcl-1/EAT in human adrenal tumors. AU - Ando, Takashi. AU - Shibata, Hirotaka. AU - Suzuki, Toshihiko. AU - Kurihara, Isao. AU - Hayashi, Kouichi. AU - Hayashi, Matsuhiko. AU - Saito, Ikuo. AU - Kawabe, Hiroshi. AU - Tsujioka, Minako. AU - Saruta, Takao. PY - 1998/1/1. Y1 - 1998/1/1. N2 - The expression levels of bcl-2, mcl-1/EAT, and bax were examined by Northern blot analysis and semi-quantitative RT-PCR method in 25 adrenal tumors, including seven adrenal pheochromocytomas (PHE), seven aldosterone- producing adenomas (APA), four adrenal cortisol-producing adenomas (CS), one deoxycorticosterone-producing adenoma (DOC) and six non-hyperfunctioning adrenal cortical adenomas (NF). Northern blot analysis revealed both bcl-2 and mcl-1/EAT mRNAs in all of the adrenal tumors. The expression levels differed greatly among the tumor samples. Mcl-1/EAT mRNA levels were enhanced in APA and CS compared with those in NF. In ...
The majority of people with adrenal adenomas will have no symptoms and the growths will only be discovered during a MRI or CT completed for other reasons. These non-functioning adrenal adenomas do not require follow up treatment.. Functional adrenal adenomas will increase hormones made in the adrenal gland.. ...
Top 10 cancers for NM_000624 (Homo sapiens, RefSeq): cortex of adrenal gland, adrenal cortical adenoma, NOS, cortex of adrenal gland, adrenal gland, cortex of adrenal gland, adrenal cortical carcinoma, adrenal gland, aldosterone-producing adenoma, adrenal gland, unspecified, neoplasms of endocrine glands and related structures, liver, hepatoblastoma, NOS, liver, hepatocellular carcinoma, NOS,metastatic, PDX/CDX, liver, dysplastic nodule
TY - JOUR. T1 - Dopaminergic Regulation of Aldosterone Secretion. T2 - Its Pathophysiologic Significance in Subsets of Primary Aldosteronism. AU - Naruse, Mitsuhide. AU - Naruse, Kiyoko. AU - Yoshimoto, Takanobu. AU - Tanaka, Masami. AU - Tanabe, Akiyo. AU - Imaki, Toshihiro. AU - Shibasaki, Tamotsu. AU - Demura, Reiko. AU - Demura, Hiroshi. PY - 1995/1/1. Y1 - 1995/1/1. N2 - Although aldosterone (Aldo.) secretion is regulated by various humoral factors, evidence has accumulated to support an involvement of dopaminergic system in its regulation. The pathophysiological significance of the dopaminergic system in primary aldosteronism (PA) however remains unknown. In the present study, we examined the effects of metoclopramide (MCP) on Aldo. secretion in normal subjects (w=ll) and patients with essential hypertension (EH, w = 8), aldosterone-producing adenoma (APA, n = 10), and idiopathic hyper aldosteronism (IHA, n = 6). Plasma Aldo., prolactin (PRL), renin, Cortisol, serum sodium, and serum ...
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1. Albert, E., Dalaker, K., Jorde, R., et al. [email protected] disease and pregnancy. Acta Obstet Gynecol Scand, 1989, 68, 2, p. 185-187. 2. Arnaldi, G., Angeli, A., Atkinson, AB., et al. Diagnosis and complications of Cushings syndrome: a consensus statement. JCEM, 2003, 88, p. 5593-5602. 3. De Groot, PC., Van Kamp, IL., Zweers, EJ., et al. Oligohydramnios in a pregnant woman with Cushings syndrome caused by an adrenocortical adenoma. J Matern Fetal Neonatal Med, 2007, 20, p. 431-434. 4. Gradden, C., Lawrence, D., Doyle, PM., et al. Uses of error: Addisons disease in pregnancy. Lancet, 2001, 375, p. 1197. 5. Hammond, TG., Buchanan, JG., Scoggins, BA., et al. Primary hyperaldosteronism in pregnancy. Aus NZ J Med, 1982, 12, p. 537-539. 6. Kar, P., Cummings, M. Pregnancy, hyperaldosteronism and an adrenal mass - were we Conned? Endocrine abstracts, 2007, 13, p. 35. 7. Kita, M., Sakalidou, M., Sarazatis, A., et al. Cushings syndrome in pregnancy: report of a case and reviw of the literature. Hormones ...
Aldosterone-producing adenomas (APAs) are benign tumors of the adrenal gland that constitutively produce the salt-retaining steroid hormone aldosterone and cause millions of cases of severe hypertension worldwide. Either of 2 somatic mutations in the potassium channel KCNJ5 (G151R and L168R, hereafter referred to as KCNJ5MUT) in adrenocortical cells account for half of APAs worldwide. These mutations alter channel selectivity to allow abnormal Na+ conductance, resulting in membrane depolarization, calcium influx, aldosterone production, and cell proliferation. Because APA diagnosis requires a difficult invasive procedure, patients often remain undiagnosed and inadequately treated. Inhibitors of KCNJ5MUT could allow noninvasive diagnosis and therapy of APAs carrying KCNJ5 mutations. Here, we developed a high-throughput screen for rescue of KCNJ5MUT-induced lethality and identified a series of macrolide antibiotics, including roxithromycin, that potently inhibit KCNJ5MUT, but not KCNJ5WT. ...
Aldosterone-producing adenomas (APAs) are benign tumors of the adrenal gland that constitutively produce the salt-retaining steroid hormone aldosterone and cause millions of cases of severe hypertension worldwide. Either of 2 somatic mutations in the potassium channel KCNJ5 (G151R and L168R, hereafter referred to as KCNJ5MUT) in adrenocortical cells account for half of APAs worldwide. These mutations alter channel selectivity to allow abnormal Na+ conductance, resulting in membrane depolarization, calcium influx, aldosterone production, and cell proliferation. Because APA diagnosis requires a difficult invasive procedure, patients often remain undiagnosed and inadequately treated. Inhibitors of KCNJ5MUT could allow noninvasive diagnosis and therapy of APAs carrying KCNJ5 mutations. Here, we developed a high-throughput screen for rescue of KCNJ5MUT-induced lethality and identified a series of macrolide antibiotics, including roxithromycin, that potently inhibit KCNJ5MUT, but not KCNJ5WT. ...
Recent genetic examinations and multisteroid profiles have provided the basis for subclassification of aldosterone-producing adenomas (APAs). The objective of the current study was to produce a comprehensive, high-resolution mass spectrometry imaging (MSI) map of APAs in relation to morphometry, immunohistochemical profiles, mutational status, and clinical outcome. The study cohort comprised 136 patients with unilateral primary aldosteronism. Matrix-assisted laser desorption/ionization-Fourier transform-ion cyclotron resonance MSI was conducted, and metabolite profiles were analyzed with genotype/phenotype information, including digital image analysis from morphometry and IHC of steroidogenic enzymes. Distinct molecular signatures between KCNJ5- and CACNA1D-mutated APAs with significant differences of 137 metabolites, including metabolites of purine metabolism and steroidogenesis, were observed. Intratumor concentration of 18-oxocortisol and 18-hydroxycortisol were inversely correlated with the ...
Adrenal venous sampling probably has its greatest utility when adrenal imaging findings are completely normal despite biochemical evidence for primary aldosteronism and in settings in which bilateral ... more
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It is well known that primary aldosteronism (PA) is the most common form of secondary hypertension, and also that aldosterone-producing adenoma and bilateral are the most common forms of PA.
The Aldosteronoma Resolution Score (ARS) is currently the most accurate prediction model for complete resolution of hypertension after adrenalectomy, taking into account 4 preoperative clinical parame... more
A Weiss unit is based on the T4 DNA ligase catalyzed ATP-PPi exchange reaction as described by Bernard Weiss, Charles Richardson and colleagues (Weiss, B., et. al., (1968) |em|J. Biol. Chem.|/em|, 243, 4556).
Adrenal CT Image shows a tumor on the left adrenal gland of 202 × 127 × 202 mm (white arrow) that displaces ipsilateral kidney and renal cysts.
AB - Steroid glucuronidation was investigated in solubilized female rat and rabbit liver microsomes and in preparations of UDP-glucuronsyltransferase (UDPGT) activity resolved from these organelles. Solubilized rabbit liver microsomes possessed
Incidentaloma is a made-up word that refers to a benign tumor discovered incidentally, usually by some imaging exam such as CT or MRI. Dangers and treatments vary.
Incidentaloma is a made-up word that refers to a benign tumor discovered incidentally, usually by some imaging exam such as CT or MRI. Dangers and treatments vary.
Incidentaloma is a made-up word that refers to a benign tumor discovered incidentally, usually by some imaging exam such as CT or MRI. Dangers and treatments vary.
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View mouse Tarbp2 Chr15:102518192-102523676 with: phenotypes, sequences, polymorphisms, proteins, references, function, expression
Expression of TARBP1 (TRM3, TRP-185) in adrenal gland tissue. Antibody staining with HPA024632 and CAB020810 in immunohistochemistry.
antibody-antibodies.com is the marketplace for research antibodies. Find the right antibody for your research needs. A TARBP2 mutation in human cancer impairs microRNA processing and DICER1 function.
Introductory Statistics 9th edition by Neil A. Weiss Test bank Questions Full Chapters are included Download Free Sample Do you need Solution manual for this
Alison Weiss, PhD is a member of the University of Cincinnati College of Medicine and Professor of Molecular Genetics, Biochemistry and Microbiology
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Fingerprint Fingerprint is based on mining the text of the persons scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher. ...
N Nagot, A Ouedraogo, H A Weiss, I Konate, A Sanon, M-C Defer, A Sawadogo, J-B Andonaba, R Vallo, P Becquart, M Segondy, P Mayaud, P Van de Perre ...
Imaging to detect an Adrenocortical adenoma may also be considered.[citation needed] Aldosterone deficiency should be treated ...
"Primary hyperaldosteronism in a domestic ferret with an adrenocortical adenoma". Journal of the American Veterinary Medical ...
Examples include thyroid adenomas and adrenocortical adenomas. Although most benign tumors are not life-threatening, many types ... Adenomas of the rectum may be treated with sclerotherapy, a treatment in which chemicals are used to shrink blood vessels in ... Pituitary adenomas can cause elevated levels of hormones such as growth hormone and insulin-like growth factor-1, which cause ... A prominent and well studied example of this phenomenon is the tubular adenoma, a common type of colon polyp which is an ...
"Expression of CYP11B2 in Aldosterone-Producing Adrenocortical Adenoma: Regulatory Mechanisms and Clinical Significance". The ...
Molecular basics of aldosterone and cortisol synthesis in normal adrenals and adrenocortical adenomas]". Endokrynologia Polska ... Compare these effects to those seen in Conn's disease, an adrenocortical tumor which causes excess release of aldosterone, that ... October 2004). "[Childhood adrenocortical tumors]". Arquivos Brasileiros de Endocrinologia e Metabologia (in Portuguese). 48 (5 ...
... adrenocortical adenomas and pheochromocytomas". Regulatory Peptides. 104 (1-3): 161-5. doi:10.1016/S0167-0115(01)00359-7. PMID ... "Orexin A stimulates cortisol secretion from human adrenocortical cells through activation of the adenylate cyclase-dependent ...
Functional adrenocortical adenomas are surgically curable.[citation needed] Most of the adrenocortical adenomas are less than 2 ... They should not be confused with adrenocortical "nodules", which are not true neoplasms. Adrenocortical adenomas are uncommon ... Grossly, adrenocortical adenomas are encapsulated, well-circumscribed, solitary tumors with solid, homogeneous yellow-cut ... Most adrenal pheochromocytomas and all adrenocortical adenomas are benign tumors, which do not metastasize or invade nearby ...
Unilateral primary hyperaldosteronism due to an adrenocortical adenoma or adrenocarcinoma can be potentially cured surgically. ... One type is caused by a unilateral aldosterone-producing adenoma or adenocarcinoma. The other type, known as idiopathic ... Bilateral primary hyperaldosteronism due to hyperplasia of the zona glomerulosa or metastasized adrenocortical adenocarcinoma ...
Mir-210 has been suggested as a useful biomarker to distinguish adrenocortical carcinoma from adrenocortical adenoma. in ... "Analysis of circulating microRNAs in adrenocortical tumors". Laboratory Investigation; A Journal of Technical Methods and ...
"Characterization of Serotonin4 Receptors in Adrenocortical Aldosterone-Producing Adenomas: In Vivo and in Vitro Studies". ... Ehrhart-Bornstein, M.; Hilbers, U. (1998). "Neuroendocrine Properties of Adrenocortical Cells" (PDF). Hormone and Metabolic ... acts in this location The expression of neuron-specific proteins in the zona glomerulosa cells of human adrenocortical tissues ... which suggests that calcium-channel blockers may directly influence the adrenocortical biosynthesis of aldosterone in vivo. ...
... esophageal leiomyoma and adrenocortical adenoma. The original description employed the then-prevailing terminology of gastric ...
March 2002). "Characterization of serotonin(4) receptors in adrenocortical aldosterone-producing adenomas: in vivo and in vitro ... The primary mineralocorticoid, aldosterone, is produced in the adrenocortical zona glomerulosa by the action of the enzyme ... Ehrhart-Bornstein M, Hilbers U (1998). "Neuroendocrine properties of adrenocortical cells". Horm. Metab. Res. 30 (6-7): 436-9. ... Adrenal insufficiency (e.g. due to Addison's disease) Cushing's syndrome Cushing's disease Conn's syndrome Adrenocortical ...
March 2002). "Characterization of serotonin(4) receptors in adrenocortical aldosterone-producing adenomas: in vivo and in vitro ... It is also a secondary site of androgen synthesis.[2] A 1998 study suggests that adrenocortical cells under pathological as ... Ehrhart-Bornstein M, Hilbers U (1998). "Neuroendocrine properties of adrenocortical cells". Horm. Metab. Res. 30 (6-7): 436-9. ... The primary mineralocorticoid, aldosterone, is produced in the adrenocortical zona glomerulosa by the action of the enzyme ...
... adrenocortical adenomas, and adrenocortical carcinoma, as well as adrenal hyperplasia due to pituitary adenomas (as in ...
Other mutations and genetic alterations in the PRKACA gene have been identified in adrenocortical adenomas that also disrupt ...
"Characterization of Serotonin4 Receptors in Adrenocortical Aldosterone-Producing Adenomas: In Vivo and in Vitro Studies". ... which suggests that calcium-channel blockers may directly influence the adrenocortical biosynthesis of aldosterone in vivo.[9] ... The expression of neuron-specific proteins in the zona glomerulosa cells of human adrenocortical tissues has been predicted and ... "Basal Steroidogenic Activity of Adrenocortical Cells is Increased 10-Fold by Coculture with Chromaffin Cells". Endocrinology. ...
"Preproorexin and orexin receptors are expressed in cortisol-secreting adrenocortical adenomas, and orexins stimulate in vitro ... "Orexins stimulate glucocorticoid secretion from cultured rat and human adrenocortical cells, exclusively acting via the OX1 ...
... gene selective Alzheimer's disease indicator-1 in the normal adrenal cortex and in adrenocortical adenomas and carcinomas". J. ...
... adrenocortical adenoma MeSH C19.053.347.500.750 - adrenocortical carcinoma MeSH C19.053.500.263 - addison disease MeSH C19.053. ... adrenocortical adenoma MeSH C19.053.098.265.750 - adrenocortical carcinoma MeSH C19.053.347.500 - adrenal cortex neoplasms MeSH ... adrenocortical adenoma MeSH C19.344.078.265.750 - adrenocortical carcinoma MeSH C19.344.400.500 - multiple endocrine neoplasia ... adenoma, islet cell MeSH C19.344.421.249.500 - insulinoma MeSH C19.344.421.500 - carcinoma, islet cell MeSH C19.344.421.500.124 ...
Bilateral micronodular hyperplasia is more common than unilateral adrenal adenoma. It can be asymptomatic, but these symptoms ... surgery Bilateral adrenocortical hyperplasia: aldosterone antagonist, e.g., spironolactone Secondary hyperaldosteronism (also ... was previously thought to be most commonly caused by an adrenal adenoma, termed Conn's syndrome. However, recent studies have ... Alkalosis Investigations High serum aldosterone Low serum renin High-resolution CT abdomen Management Adrenal adenoma: ...
Adrenocortical adenoma 3: Undetermined 4-9: Adrenocortical carcinoma The only curative treatment is complete surgical excision ... Adrenocortical adenoma Renal cell carcinoma Pheochromocytoma Hepatocellular carcinoma Adrenocortical carcinomas are most ... The presence of invasion and mitotic activity help differentiate small cancers from adrenocortical adenomas. Several relatively ... such as adrenocortical adenoma, and determining the extent of invasion of the tumor into surrounding organs and tissues. On CT ...
... 3: Undetermined 4-9: Adrenocortical carcinoma Non-functioning cases of adrenocortical adenoma can be ... Like most adenomas, the adrenocortical adenoma is considered a benign tumor since the majority of them are non-functioning and ... Adrenocortical adenomas are most commonly distinguished from adrenocortical carcinomas (their malignant counterparts) by the ... protein kinase A pathways have been implicated in the adrenocortical pathophysiology. If functional, adrenocortical adenomas ...
... adrenocortical adenoma MeSH C04.588.322.078.265.750 - adrenocortical carcinoma MeSH C04.588.322.400 - multiple endocrine ... adenoma, bile duct MeSH C04.557.470.035.095 - adenoma, chromophobe MeSH C04.557.470.035.100 - adenoma, islet cell MeSH C04.557. ... adenoma MeSH C04.557.470.035.012 - acth-secreting pituitary adenoma MeSH C04.557.470.035.025 - adenoma, acidophil MeSH C04.557. ... adenoma, oxyphilic MeSH C04.557.470.035.155 - adenoma, pleomorphic MeSH C04.557.470.035.175 - adenoma, sweat gland MeSH C04.557 ...
Adrenocortical adenoma/Adrenocortical carcinoma. *Hurthle cell. Other/multiple. *Neuroendocrine tumor *Carcinoid. *Adenoid ...
Adrenocortical adenoma. *Adrenocortical carcinoma. *Adrenocorticotropic hormone deficiency. *Adrenoleukodystrophy. *Adult ...
Thyroid adenoma. *Struma ovarii. Adrenal tumor. *Cortex *Adrenocortical adenoma. *Adrenocortical carcinoma. *Medulla * ...
Thyroid adenoma. *Struma ovarii. Adrenal tumor. *Cortex *Adrenocortical adenoma. *Adrenocortical carcinoma. *Medulla * ...
The older names, "multiple endocrine adenomas" and "multiple endocrine adenomatosis" (MEA), have been replaced by the current ... Other endocrine and non-endocrine neoplasms including adrenocortical and thyroid tumors, visceral and cutaneous lipomas, ... In 1903 Erdheim described the case of an acromegalic patient with a pituitary adenoma and three enlarged parathyroid glands. ... In 1961 Sipple described a combination of a pheochromocytoma, medullary thyroid carcinoma and parathyroid adenoma. ...
A prolactinoma is a benign tumor (adenoma) of the pituitary gland that produces a hormone called prolactin. It is the most ... In non-selective surgical series, this tumor accounts for approximately 25-30% of all pituitary adenomas.[8] Some growth ... "Demographic differences in incidence for pituitary adenoma". Pituitary. 14 (1): 23-30. doi:10.1007/s11102-010-0253-4. PMC ... Adrenocortical adenoma/Adrenocortical carcinoma. *Hürthle cell. Other/multiple. *Neuroendocrine tumor *Carcinoid. *Adenoid ...
... (also known as hepatic adenoma or hepadenoma) is a rare, benign liver tumor. It most commonly occurs in ... The histologic diagnosis of hepatic adenomas can be aided by reticulin staining. In hepatic adenomas, the reticulin scaffold is ... Pregnancy could cause the adenoma to grow faster, so patients with hepatic adenomas should avoid pregnancy.[10] ... "Hepatocellular Adenoma: eMedicine Gastroenterology".. *^ a b c Anthony S. Fauci; Eugene Braunwald; Dennis L. Kasper; Stephen L ...
Pituitary adenomas are responsible for 80% of endogenous Cushing's syndrome,[3] when excluding Cushing's syndrome from ... The other hypothesis was that Minnie might have suffered from Primary Pigmented Nodular Adrenocortical Disease (PPNAD), which ... The first-line treatment of Cushing's disease is surgical resection of ACTH-secreting pituitary adenoma; this surgery involves ... Ding D, Starke RM, Sheehan JP (May 2014). "Treatment paradigms for pituitary adenomas: defining the roles of radiosurgery and ...
Adrenocortical adenoma/Adrenocortical carcinoma. *Hurthle cell. Other/multiple. *Neuroendocrine tumor *Carcinoid. *Adenoid ...
腎上腺皮質腺瘤(英语:Adrenocortical adenoma). *腎上腺皮質癌(英语:Adrenocortical carcinoma)(ACC) ... 垂體腺瘤(英语:Pituitary adenoma):泌乳
Adrenocortical adenoma(英语:Adrenocortical adenoma)/Adrenocortical carcinoma(英语:Adrenocortical carcinoma) ... 囊性肿瘤: 浆液性微囊性腺癌(英语:Serous microcystic adenoma) ...
Tumors with increased risk in this disorder are colorectal cancer, gastric adenomas and duodenal adenomas. Nevoid basal cell ... Genetic testing should be considered with adrenocortical carcinoma; carcinoid tumors; diffuse gastric cancer; fallopian tube/ ... An individual with this disease will have hundreds to thousands of benign adenomas throughout their colon, which will in most ... Other tumors increased in frequency include; osteomas, adrenal adenomas and carcinomas, thyroid tumors and desmoid tumors. The ...
Adrenocortical carcinoma. *Islet cell carcinoma (endocrine pancreas). *Multiple endocrine neoplasia syndrome. *Parathyroid ... Pituitary adenoma. *Visual pathway and hypothalamic glioma. Breast[edit]. *Breast cancer. *Invasive lobular carcinoma ...
Endocrine disease is characterized by irregulated hormone release (a productive pituitary adenoma), inappropriate response to ... "Adrenocortical control of epinephrine synthesis". Pharmacological Reviews. 23 (1): 1-35. PMID 4941407 ... due to a pituitary adenoma that ultimately causes endogenous hypercortisolism by stimulating the adrenal glands.[10] Some ...
Examples include thyroid adenomas and adrenocortical adenomas.[2]. Although most benign tumors are not life-threatening, many ... Adenomas of the rectum may be treated with sclerotherapy, a treatment in which chemicals are used to shrink blood vessels in ... Insulinomas can produce large amounts of insulin leading to hypoglycemia.[8][9] Pituitary adenomas can cause elevated levels of ... June 1999). "Clinical and morphological features of undifferentiated monomorphous GH/TSH-secreting pituitary adenoma". Eur. J. ...
Most people with the disorder have a single adenoma. This form of the syndrome, known as Cushing's disease. ... "Response of plasma ACTH and adrenocortical hormones to potassium loading in essential hypertension". Japanese Circulation ...
In addition, there appears to be an increased risk of colorectal cancer and pre-malignant tubular adenomas in acromegaly. In ... and adrenocortical function in normal young men". J. Clin. Endocrinol. Metab. 81 (8): 2776-2782. doi:10.1210/jcem.81.8.8768828 ...
Emergencies arising from decompensated pheochromocytomas or parathyroid adenomas are sometimes referred for emergency resection ... acute adrenocortical insufficiency, phaeochromocytoma crisis, hypercalcemic crisis, thyroid storm, myxoedema coma and pituitary ... "A parathyroid adenoma: benign disease presenting with hyperparathyroid crisis". Case Reports in Medicine. 2010: 596185. doi ...
Pleomorphic adenoma. References[edit]. *^ Witt, Robert L., ed. (2005). "Chapter 9 "Benign tumors, cysts, and tumor-like ... Though much less likely to occur than pleomorphic adenoma, Warthin's tumor is the second most common benign parotid tumor. ... Adrenocortical adenoma/Adrenocortical carcinoma. *Hurthle cell. Other/multiple. *Neuroendocrine tumor *Carcinoid. *Adenoid ...
... adrenocortical adenomas, and adrenocortical carcinoma, as well as adrenal hyperplasia due to pituitary adenomas (as in ...
Conn's syndrome is primary hyperaldosteronism caused by an aldosterone-producing adenoma. Depending on cause and other factors ... which suggests that Ca2+ channel blockers may directly influence the adrenocortical biosynthesis of aldosterone in vivo.[20] ... "Aldosterone-to-renin ratio for diagnosing aldosterone-producing adenoma: a multicentre study". Archives of Cardiovascular ... of renin to aldosterone is an effective screening test to screen for primary hyperaldosteronism related to adrenal adenomas.[38 ...
Pohorecky LA, Wurtman RJ (March 1971). "Adrenocortical control of epinephrine synthesis". Pharmacological Reviews. 23 (1): 1-35 ... Endocrine disease is characterized by misregulated hormone release (a productive pituitary adenoma), inappropriate response to ... due to a pituitary adenoma that ultimately causes endogenous hypercortisolism by stimulating the adrenal glands.[11] Some ...
An ACTH-secreting corticotrophic pituitary adenoma should be removed after diagnosis. Regardless of the adenoma's location, ... Fudge EB, von Allmen D, Volmar KE, Calikoglu AS (2009). "Cushing Syndrome in a 6-Month-Old Infant due to Adrenocortical Tumor ... Cases due to a pituitary adenoma are known as Cushing's disease, which is the second most common cause of Cushing's syndrome ... In pituitary Cushing's, a benign pituitary adenoma secretes ACTH. This is also known as Cushing's disease and is responsible ...
The mean percent methylation of H19 CpGs peaked at sites 9 and 10 in normal, hyperplasia, adenoma and carcinoma adrenals and ... In contrast to most other cancers, adrenocortical neoplasms appear to have decreased expression of H19. To determine a possible ... studied the methylation of 12 CpG sites in the H19 promoter in normal, hyperplasia, adenoma and carcinoma adrenals. They found ... The mean percent CpG methylation at site 11 for hyperplasia and adenoma adrenals is significantly different from that of normal ...
544-. ISBN 978-3-642-60107-1. Kovacs K, Stefaneanu L, Ezzat S, Smyth HS (May 1994). "Prolactin-producing pituitary adenoma in a ... "Effect of oestrogen or cyproterone acetate treatment on adrenocortical function in prostate carcinoma patients". Acta ...
"WNT-4 mRNA expression in human adrenocortical tumors and cultured adrenal cells". Hormone and Metabolic Research. 40 (10): 668- ... "Expression of Wnt4 in human pituitary adenomas regulates activation of the beta-catenin-independent pathway". Endocrine ...
Adrenocortical adenoma 3: Undetermined 4-9: Adrenocortical carcinoma Non-functioning cases of adrenocortical adenoma can be ... Like most adenomas, the adrenocortical adenoma is considered a benign tumor since the majority of them are non-functioning and ... Adrenocortical adenomas are most commonly distinguished from adrenocortical carcinomas (their malignant counterparts) by the ... protein kinase A pathways have been implicated in the adrenocortical pathophysiology. If functional, adrenocortical adenomas ...
... Lea F. Surrey,1 Ashesh ... "ACTH-independent Cushings syndrome with bilateral micronodular adrenal hyperplasia and ectopic adrenocortical adenoma," ... S. K. Lau and L. M. Weiss, "The Weiss system for evaluating adrenocortical neoplasms: 25 years later," Human Pathology, vol. 40 ... H. Ohtake, H. Kawamura, M. Matsuzaki et al., "Oncocytic adrenocortical carcinoma," Annals of Diagnostic Pathology, vol. 14, no ...
Adrenocortical Adenoma. A benign Neoplasm of the Adrenal Cortex. It is characterized by a well-defined nodular lesion, usually ... Most adrenocortical Adenomas are nonfunctional. The functional ones are yellow and contain Lipids. Depending on the Cell type ...
Gene context of Adrenocortical Adenoma. *COUP-TFI expression in human adrenocortical adenomas: possible role in steroidogenesis ... High impact information on Adrenocortical Adenoma. *In addition, adrenocortical adenomas, spontaneous to Syrian golden hamsters ... CREB protein status was studied by Western blotting in adrenocortical adenomas (AAs, n = 27) and adrenocortical carcinomas (ACs ... Urotensin II-like immunoreactivity was detected in one of eight adrenocortical adenomas, two of four adrenocortical carcinomas ...
Bilateral adrenocortical adenomas causing adrenocorticotropic hormone-independent Cushings syndrome: A case report and review ... Cases of ACTH-independent CS associated with adrenocortical adenoma are secondary to unilateral adrenocortical adenomas in ... Table 1 Endocrinological study at different periods of bilateral adrenocortical adenomas. Baseline. Low-dose dexam test. High- ... A case report of Cushings syndrome due to bilateral adrenocortical adenomas. Zhonghua Neifenmidaixie Zazhi. 2001;17:188-189. [ ...
Keyword(s) : Adrenocortical adenoma, Case report, Conn's syndrome, ECG, Endocrinology, Primary aldosteronism and Surgery ... oa South African Medical Journal - Primary aldosteronism due to adrenocortical adenoma (Conn's syndrome) * Navigate this ...
Virilizing adrenocortical adenoma with a paradoxic response to dexamethasone administration: report of a case. The Journal of ... Gilman D. Virilizing adrenocortical adenoma with a paradoxic response to dexamethasone administration: report of a case. J Am ... Virilizing adrenocortical adenoma with a paradoxic response to dexamethasone administration: report of a case ... Virilizing adrenocortical adenoma with a paradoxic response to dexamethasone administration: report of a case ...
Aldosterone-producing adrenocortical adenoma (APA) is responsible for the majority of cases clinically diagnosed as primary ... Keywords: aldosterone-producing adrenocortical adenoma, CYP11B2, gene mutation, transcription factor, 18-oxocortisol ...
Resolution of the physical features of Cushings syndrome in a patient with a cortisol secreting adrenocortical adenoma after ... Resolution of the physical features of Cushings syndrome in a patient with a cortisol secreting adrenocortical adenoma after ... Histopathology results were consistent with an adrenocortical adenoma (2.5 cm widest dimension). Six months after surgery, ...
Resolution of the physical features of Cushings syndrome in a patient with a cortisol secreting adrenocortical adenoma after ... Resolution of the physical features of Cushings syndrome in a patient with a cortisol secreting adrenocortical adenoma after ...
... endothelial morphology and function in patients with subclinical Cushings syndrome due to single adrenocortical adenomas. ... endothelial morphology and function in patients with subclinical Cushings syndrome due to single adrenocortical adenomas (. ... Background: Subclinical Cushing s syndrome (SCS) due to incidentally discovered adrenal adenomas (AI) has been associated with ...
... of cortisol-producing adenomas (CPA) of the adrenal gland, rendering PKA signalling constitutively active. In its resting state ... Differential expression of the protein kinase A subunits in normal adrenal glands and adrenocortical adenomas. ... of cortisol-producing adenomas (CPA) of the adrenal gland, rendering PKA signalling constitutively active. In its resting state ... of cortisol-producing adenomas (CPA) of the adrenal gland, rendering PKA signalling constitutively active. In its resting state ...
Adenoma, Adrenal Cortical; Conns Disease. On-line free medical diagnosis assistant. Ranked list of possible diseases from ...
Adrenocortical... World Heritage Encyclopedia, the aggregation of the largest online encyclopedias available, and the most ... Adrenocortical adenoma: lt;table class=infobox cellspacing=3 style=border-spacing:3px;width:22em;,,,, ... A adrenocortical adenoma (or adrenal cortical adenoma) is a benign tumor of the adrenal cortex. ... Nevertheless, these apparently non-functioning adenomas are most often encountered in elder obese people. There is some debate ...
Adrenocortical carcinoma in preoperative diagnostic imaging Ziaja Jacek, Hartel Marcin, Król Robert, Kiełtyka Aleksandra, ...
Search for abbreviations and long forms in lifescience, results along with the related PubMed / MEDLINE information and co-occurring abbreviations.
Anomalous Response to Metyrapone in Cushings Syndrome Due to Adrenocortical Adenoma. Posted on June 11, 2017 by MaryO ... 24-hour urinary free cortisol 40 Days abstract ACTH Addisons disease adenoma adrenal adrenalectomy adrenal glands adrenal ... Adrenocortical Carcinoma and Pulmonary Embolism From Tumoral Extension. Cushing syndrome or a mixed picture of excess androgen ... cancer Korlym MaryO message boards mifepristone mortality MRI NIH obesity osteoporosis pasireotide pituitary Pituitary adenoma ...
... and bilateral adrenocortical adenomas (BAAs) or carcinomas. BAAs causing ACTH-independent CS are rare; up to now, fewer than 40 ... Its common causes include primary pigmented nodular adrenocortical disease, ACTH-independent macronodular adrenal hyperplasia, ... Bilateral Adrenocortical Adenomas Causing Adrenocorticotropic Hormone-Independent Cushings Syndrome. Posted on May 27, 2019 by ... and bilateral adrenocortical adenomas (BAAs) or carcinomas. BAAs causing ACTH-independent CS are rare; up to now, fewer than 40 ...
... benign adrenocortical adenomas showed high FDG accumulation (SUVmax ≥ 3). In adrenocortical adenomas with high FDG accumulation ... Nomura K, Saito H, Aiba M, Iihara M, Obara T & Takano K Cushings syndrome due to bilateral adrenocortical adenomas with unique ... Korobkin M, Giordano TJ, Brodeur FJ, Francis IR, Siegelman ES, Quint LE, Dunnick NR, Heiken JP & Wang HH Adrenal adenomas: ... Nakajo M, Nakajo M, Kajiya Y, Tani A, Tsuruta M, Sugita S, Fushitani S & Umekita Y A black adrenal adenoma difficult to be ...
A composite silent corticotroph pituitary adenoma with interspersed adrenocortical cells: Case report. Neurosurgery. 1998 Mar; ... A composite silent corticotroph pituitary adenoma with interspersed adrenocortical cells : Case report. / Coiré, Claire I.; ... keywords = "Adrenocortical cells, Immunohistochemistry, Pathological findings, Pituitary adenoma, Ultrastructure",. author = " ... CONCLUSION: We suggest that the designation composite silent corticotroph pituitary adenoma with adrenocortical cells is an ...
Using RCRFA for adrenocortical adenoma with Cushing syndrome is a feasible, safe, and promising treatment method in selected ... From May 2006 to May 2009, 12 female patients with adrenocortical adenoma and Cushing syndrome underwent RCRFA. Ten tumors were ... Retroperitoneal laparoscopic cool-tip radiofrequency ablation of adrenocortical adenoma with Cushing syndrome. View Poster ... MP03-14: Retroperitoneal laparoscopic cool-tip radiofrequ ... of adrenocortical adenoma with Cushing syndrome. ...
Steroidogenic Acute Regulatory Protein Overexpression Correlates with Protein Kinase A Activation in Adrenocortical Adenoma. . ... The association of pathological features of cortisol-producing adrenocortical adenomas ACAs with somatic driver mutations and ... Steroidogenic Acute Regulatory Protein Overexpression Correlates with Protein Kinase A Activation in Adrenocortical Adenoma. ... Steroidogenic Acute Regulatory Protein Overexpression Correlates with Protein Kinase A Activation in Adrenocortical Adenoma - ...
... hormonally inactive adrenocortical adenoma) and 3 CPA (cortisol producing adrenocortical adenoma) samples. Tissue digestion, ... microRNa expression profiling in adrenal myelolipoma, adrenocortical carcinoma and adrenocortical adenoma. Project description: ... Overall design: miRNA sequencing of 45 adrenocortical carcinomas (ACC), 30 adrenocortical adenomas (ACA) and 3 normal adrenal ... miRNA sequencing of 45 adrenocortical carcinomas (ACC), 30 adrenocortical adenomas (ACA) and 3 normal adrenal samples. ...
Final Diagnosis -- Pheochromocytoma and Adrenocortical Adenoma. FINAL DIAGNOSIS:. CORTICOMEDULLARY TUMOR OF THE LEFT ADRENAL ... These cortical adenomas occur either as a separate tumor, or as a component of CMT consisting of both cortical adenoma cells ... GLAND WITH ELEMENTS OF PHEOCHROMOCYTOMA AND ADRENOCORTICAL ADENOMA. DISCUSSION:. Corticomedullary tumor (CMT) of the adrenal ... Only a few cases have been reported in the literature consisting of nests and cords of pheochromocytoma and cortical adenoma ...
Adrenocortical Adenoma. Disease. Pathologic Processes. Alcohol-Related Disorders. Substance-Related Disorders. Chemically- ... Adrenocortical Hyperfunction. Adrenal Gland Diseases. Endocrine System Diseases. Adrenal Cortex Neoplasms. Endocrine Gland ... Genetic and Rare Diseases Information Center resources: Adenoma of the Adrenal Gland Cushing's Syndrome Hyperadrenalism ...
Adenoma. Adrenocortical Adenoma. Cushing Syndrome. Adrenocortical Hyperfunction. Neoplasms, Glandular and Epithelial. Neoplasms ... Efficacy and Safety of Relacorilant in Patients With Cortisol-Secreting Adrenal Adenomas (GRADIENT). The safety and scientific ... Genetic and Rare Diseases Information Center resources: Adenoma of the Adrenal Gland 21-hydroxylase Deficiency Congenital ... Glucocorticoid Receptor Antagonism in the Treatment of Hypercortisolism in Patients With Cortisol-Secreting Adrenal Adenomas or ...
... of autoimmune thyroid dysfunction after unilateral adrenalectomy in patients with Cushings syndrome due to an adrenocortical ... thyroid dysfunction after unilateral adrenalectomy in patients with Cushings syndrome due to an adrenocortical adenoma. ...
... in adrenocortical adenomas excised from patients with Conn and Cushing syndromes, as well as in adrenocortical adenomas excised ... in adrenocortical adenomas excised from patients with Conn and Cushing syndromes, as well as in adrenocortical adenomas excised ... On the other hand transcriptional activity of the genes within the other adrenocortical adenomas is documented in lesser degree ... On the other hand transcriptional activity of the genes within the other adrenocortical adenomas is documented in lesser degree ...
Feminizing adrenocortical adenoma: a rare cause of isosexual precocious puberty Feminizing adrenocortical adenoma: a rare cause ...
Adenoma, อะดีโนมา (th); acinar cell adenoma, acinar cell adenoma (morphologic abnormality), acinic cell adenoma, adenomas (en ... adenoma (ca); غدومہ (ur); Adenoma (ms); Аденома (ky); Adenoma (lt); Адэнома (be); adenoma (pt); برونح ادەنوماسى (kk-arab); ... Adenoma (tr); Adenomatous, ایڈینوما, ایڈینومیٹوسس, Adenoma, Adenomatosis (ur); Adenome (fr); Körtelsvulst (sv); adenoma (ca); ... adenoma (es); Bronx adenoması (kk-tr); Бронх аденомасы (kk-kz); adenoma (eu); Аденома (ru); Adenom (de); برونح ادەنوماسى (kk-cn ...
  • Giant adrenal myelolipoma associated with 21-hydroxylase deficiency: unusual association mimicking an androgen-secreting adrenocortical carcinoma," Arquivos Brasileiros de Endocrinologia e Metabologia , vol. 54, no. 4, pp. 419-424, 2010. (hindawi.com)
  • Adrenocortical carcinoma (ACC) is an aggressive malignancy with high rates of recurrence following surgical resection. (omicsdi.org)
  • We sought to describe lncRNA expression signatures in adrenocortical carcinoma (ACC), adrenal cortical adenoma (ACA) and normal adrenal cortex (NAC). (omicsdi.org)
  • Due to the variable proportion of fat and hematopoietic elements, it is sometimes challenging to differentiate AML from adrenocortical carcinoma (ACC). (omicsdi.org)
  • In the absence of local invasion or metastases, the preoperative diagnosis of an adrenocortical carcinoma (ACC) is difficult, often leaving size as the principal predictor of malignancy. (springer.com)
  • Barlaskar FM, Hammer GD (2007) The molecular genetics of adrenocortical carcinoma. (springer.com)
  • Else T, Giordano TJ, Hammer GD (2008) Evaluation of telomere length maintenance mechanisms in adrenocortical carcinoma. (springer.com)
  • Adrenal CT scan may be helpful in the diagnosis of Adrenocortical carcinoma (ACC) and in differentiating it from other diseases, such as adrenocortical adenoma . (wikidoc.org)
  • 2011). "Adrenocortical carcinoma: the range of appearances on CT and MRI." . (wikidoc.org)
  • Primary adrenocortical carcinoma: CT evaluation with clinical correlation. (wikidoc.org)
  • Computed tomography of adrenocortical carcinoma containing macroscopic fat. (wikidoc.org)
  • What is the only definite criteria for an adrenocortical carcinoma? (brainscape.com)
  • Adrenocortical carcinoma masquerading as Cushing's disease. (urotoday.com)
  • Actual 10-year survivors following resection of adrenocortical carcinoma. (urotoday.com)
  • Terzolo M et al (Jun 2007) Adjuvant mitotane treatment for adrenocortical carcinoma. (springer.com)
  • Limited prognostic value of the 2004 International Union Against Cancer staging classification for adrenocortical carcinoma: proposal for a Revised TNM Classification. (springer.com)
  • In: Hammer G., Else T. (eds) Adrenocortical Carcinoma. (springer.com)
  • Adrenocortical carcinoma is a rare, malignant tumor that can be associated with hormone secretion or can be nonfunctional. (clinicaladvisor.com)
  • This is associated with the tumor suppressor gene TP53 , which has been implicated in the higher rate of adrenocortical carcinoma in children from southern Brazil. (clinicaladvisor.com)
  • Distinguishing adenoma from carcinoma or metastatic lesion (i.e., benign lesion from malignant lesion) is imperative as the management of malignant disease necessitates surgical removal for primary tumors and treatment of the primary malignancy in the case of metastatic disease. (oncologynurseadvisor.com)
  • Adrenocortical adenomas are classified as ACTH-independent disorders, and are commonly associated with conditions linked to hyperadrenalism such as Cushing's syndrome (hypercortisolism) or Conn's syndrome (hyperaldosteronism), which is also known as primary aldosteronism. (wikipedia.org)
  • The term "Cushing's disease" refers specifically to "secondary hypercortisolism" classified as "ACTH-dependent Cushing's syndrome" caused by pituitary adenomas. (wikipedia.org)
  • In contrast, "Cushing's syndrome" refers specifically to "primary hypercortisolism" classified as "ACTH-independent Cushing's syndrome" caused by adrenal adenomas. (wikipedia.org)
  • In most reported cases of adrenocortical adenoma, patients have presented with one or multiple endocrine syndromes such as hyperaldosteronism/Conn's Syndrome, hypercortisolism/Cushing's syndrome, hyperandrogenism/feminization, virilization, or hirsutism. (wikipedia.org)
  • ACTH-independent Cushing's syndrome with bilateral micronodular adrenal hyperplasia and ectopic adrenocortical adenoma," Journal of Clinical Endocrinology and Metabolism , vol. 95, no. 1, pp. 18-24, 2010. (hindawi.com)
  • Young female patient with testosterone-producing adrenocortical adenoma alsoshowing sings of subclinical Cushing's syndrome. (nii.ac.jp)
  • Bilateral adrenocortical adenomas causing cushing's syndrome. (biomedsearch.com)
  • Cushing's syndrome , also called hypercortisolism (having abnormally high levels of cortisol), is caused by adrenal adenomas that release excess levels of the hormone cortisol. (nih.gov)
  • ACTH-dependent (secondary) adrenal hyperplasia is most commonly due to an ACTH-secreting pituitary adenoma (Cushing's disease) and ectopic ACTH from a non-pituitary tumor. (renalandurologynews.com)
  • Bilateral adrenal hyperplasia associated with an ACTH-secreting pituitary adenoma is also called Cushing's disease and will also be discussed in this section. (renalandurologynews.com)
  • GIP-dependent Cushing's syndrome is caused by ectopic expression of glucose-dependent insulinotropic polypeptide receptor (GIPR) in cortisol-producing adrenal adenomas or in bilateral macronodular adrenal hyperplasias. (jci.org)
  • Here we performed molecular analyses on adrenocortical adenomas and bilateral macronodular adrenal hyperplasias obtained from 14 patients with GIP-dependent adrenal Cushing's syndrome and one patient with GIP-dependent aldosteronism. (jci.org)
  • Aldosterone- and cortisol-producing adenomas (APAs and CPAs) are benign tumors of the adrenal cortex that cause excess hormone production, leading to primary aldosteronism and Cushing's syndrome, respectively. (frontiersin.org)
  • Overexpression of glutathione S-transferase A1 (GSTA1) in benign adrenocortical adenomas from patients with Cushing's syndrome'Journal Clnical Endocrinology and Metabolism. (nii.ac.jp)
  • Funahashi H,Seo H.: 'Expression of adrenocorticotropin receptor gene in adrenocortical adenomas from patients with Cushing's syndrome : Possible contribution for the autonomous production of cortisol. (nii.ac.jp)
  • The pathology included nonsecreting benign adrenocortical adenoma in 2 patients and pheochromocytoma, subclinical Cushing's and lymphangioma in 1 patient each. (sages.org)
  • Cushing's syndrome is a clinical condition resulting from excessive levels of circulating glucocorticoids and can be caused by adrenocortical adenomas. (oncologynurseadvisor.com)
  • Patients with Cushing's syndrome caused by a hypersecretory adenoma usually have central obesity with thin extremities and weight gain is almost always present. (oncologynurseadvisor.com)
  • Adrenal adenomas are often categorized as endocrine-inactive tumors considering that majority of them are non-functioning and asymptomatic. (wikipedia.org)
  • correspondingly, the developmental physiology of the adrenal cortex is believed to play a pivotal role in formation of the adrenocortical tumors. (wikipedia.org)
  • Adrenocortical oncocytic tumors: report of 10 cases and review of the literature," International Journal of Surgical Pathology , vol. 12, no. 3, pp. 231-243, 2004. (hindawi.com)
  • Although 18 F-FDG PET was originally developed to evaluate benign and malignant tumors, the frequency of detection of benign adrenocortical adenomas showing FDG-PET accumulation has increased. (bioscientifica.com)
  • To elucidate the pathophysiology of FDG-PET-positive cortisol-producing adrenal tumors, we performed clinicopathological and genetic analyses of adrenocortical adenomas examing FDG-PET in 30 operated patients with unilateral cortisol-producing adrenal tumors (26 adrenal adenomas and 4 adrenal cancers). (bioscientifica.com)
  • Black adrenal adenomas should be considered with adrenal tumors showing PET accumulation and low lipid contents. (bioscientifica.com)
  • The new tests being investigated at Houston Methodist not only have the potential to lead to better diagnoses for patients with pituitary adenomas, but also for many other types of brain tumors in the future. (cushieblog.com)
  • MicroRNAs have been identified as promising biomarkers in many tumors, including adrenocortical neoplasms, but the microRNA expression of adrenal myelolipoma has not been investigated, yet. (omicsdi.org)
  • Aims: To perform a large scale microRNA expression profiling in adrenal myelolipoma, benign and malignant adrenocortical tumors to identify potential microRNA biomarkers. (omicsdi.org)
  • Micro-RNA sequencing of adrenocortical tumors and normal adrenal samples. (omicsdi.org)
  • Histology confirmed a cortical adenoma in eight patients, malignant tumors in three, and indeterminate tumors in eight. (springer.com)
  • We provide an algorithm for the approach to adrenocortical tumors ≥ 6 cm. (springer.com)
  • The majority of adrenal tumors are clinically nonfunctioning, benign adrenocortical adenomas and usually do not require surgical intervention. (springer.com)
  • Giordano TJ (2006) Molecular pathology of adrenal cortical tumors: separating adenomas from carcinomas. (springer.com)
  • Adenomas of the adrenal gland are non-cancerous (benign) tumors on the adrenal gland . (nih.gov)
  • Adrenal adenomas are benign tumors of the adrenal glands. (oncologynurseadvisor.com)
  • To provide additional insight into the nature of ACT, we determined the gene expression profiles of 24 pediatric tumors (five adenomas, 18 carcinomas, and one undetermined) and seven normal adrenal glands. (stjuderesearch.org)
  • Adrenocortical tumors can be divided into benign or malignant, as well as "functional" or "nonfunctional" in reference to whether or not they secrete hormones. (clinicaladvisor.com)
  • Pheochromocytomas are tumors that arise from the adrenal medulla and thus are not considered adrenocortical tumors. (clinicaladvisor.com)
  • Most tumors are sporadic, but genetic alterations in adrenal signaling pathways have been implicated in the formation of benign adenomas, both functional and nonfunctional. (clinicaladvisor.com)
  • DHEA-S, testosterone, androstenedione, 17-OH progesterone, serum estradiol (high-sensitivity assay), estrone, as well as urinary 17-ketosteroids, which tend to be elevated in the majority of patients with adrenocortical tumors, and urinary total estrogens should be evaluated. (clinicaladvisor.com)
  • Background Adrenocortical tumors comprise frequent adenomas (ACA) and rare carcinomas (ACC). (uni-wuerzburg.de)
  • Material and Methods CYP2W1 expression was investigated by qRT-PCR in 13 normal adrenal glands, 32 ACA, 25 ACC, and 9 different non-adrenal normal tissue samples and by Background Adrenocortical tumors comprise frequent adenomas (ACA) and rare carcinomas (ACC). (uni-wuerzburg.de)
  • Although pheochromocytomas showed higher apparent diffusion coefficient (ADC) values in this series, ADC value has not been found to have significant utility for differentiating adenomas and metastatic tumors. (appliedradiology.com)
  • Adrenal adenomas are benign tumors of the adrenal glands, which can be either functioning or non-functioning. (oncologynurseadvisor.com)
  • Tumor size and attenuation value in Hounsfield units (HU) are the imaging characteristics that are most useful in differentiating between adenomas and non-adenomas, including adrenocortical cancers, metastases and pheochromocytomas (see Table I ). Tumors smaller than 4 cm with an attenuation value of 10HU or less are highly likely to be adenomas. (oncologynurseadvisor.com)
  • This is a Phase 3, randomized, double-blind, placebo-controlled study to assess the efficacy, and safety of relacorilant to treat hypercortisolism in patients with cortisol-secreting adrenal adenoma or hyperplasia associated with diabetes mellitus/ impaired glucose tolerance and/or uncontrolled systolic hypertension. (clinicaltrials.gov)
  • Surgery is the treatment of choice for the lateralizable variants of primary aldosteronism, including typical aldosteronomas, renin-responsive adenomas (RRAs), and primary adrenal hyperplasia (PAH). (medscape.com)
  • Briefly describe how congenital problems can cause adrenocortical hyperplasia? (brainscape.com)
  • What are the 2 causes of endogenous ACTH production in acquired adrenocortical hyperplasia? (brainscape.com)
  • With adrenocortical hyperplasia, is the adrenal gland enlargement diffuse or nodular? (brainscape.com)
  • What are acquired forms of adrenocortical hyperplasia? (brainscape.com)
  • Moreover, reports have described a rare syndrome of primary aldosteronism characterized by histologic features intermediate between adrenal adenoma and adrenal hyperplasia, which often is unilaterally localized (also referred to earlier literature as "intermediate aldosteronism") (see Etiology). (medscape.com)
  • ACTH-independent (primary) adrenal hyperplasia in bilateral glands ia usually due to two main types of adrenal nodular hyperplasias: ACTH-independent bilateral macronodular adrenal hyperplasia (AIMAH) or primary pigmented adrenocortical disease (PPNAD) and will be discussed here. (renalandurologynews.com)
  • Imaging will also help to identify the presence of an adrenal adenoma, as opposed to hyperplasia of the glands. (renalandurologynews.com)
  • GIPR expression in all adenoma and hyperplasia samples occurred through transcriptional activation of a single allele of the GIPR gene. (jci.org)
  • In 2 adenoma samples, the duplicated 19q13.32 region was rearranged with other chromosome regions, whereas a single tissue sample with hyperplasia had a 19q duplication only. (jci.org)
  • germline mutations in a regulatory subunit of the cyclic adenosine monophosphate (cAMP) signaling pathway have been implicated in a form of bilateral adrenal hyperplasia-primary pigmented nodular adrenocortical disease. (clinicaladvisor.com)
  • Likewise, Conn's syndrome is primary hyperaldosteronism (PH), either from an aldosterone-producing adenoma or bilateral idiopathic hyperplasia. (oncologynurseadvisor.com)
  • Like most adenomas, the adrenocortical adenoma is considered a benign tumor since the majority of them are non-functioning and asymptomatic. (wikipedia.org)
  • Moreover, recent studies suggest that mutations affecting the molecular pathways of the adrenocortical region can stimulate abnormal proliferation and tumor formation. (wikipedia.org)
  • A adrenocortical adenoma (or adrenal cortical adenoma ) is a benign tumor of the adrenal cortex . (worldlibrary.net)
  • OBJECTIVE AND IMPORTANCE: A case report of an extraordinary sellar pituitary tumor composed of corticotrophs and adrenocortical cells is presented. (elsevier.com)
  • The nature of the tumor was revealed by ultrastructural examination, thus highlighting the importance of this technique in the investigation of pituitary adenomas. (elsevier.com)
  • CONCLUSION: We suggest that the designation 'composite silent corticotroph pituitary adenoma with adrenocortical cells' is an appropriate name for this tumor. (elsevier.com)
  • Only a few cases have been reported in the literature consisting of nests and cords of pheochromocytoma and cortical adenoma growing within the same tumor mass (1). (upmc.edu)
  • Microscopically, CMT is characterized by a mixture of medullary pheochromocytoma cells with adrenocortical tumor cells (IMAGE 01 ) creating a composite tumor having both cortical and medullary characteristics. (upmc.edu)
  • These cortical adenomas occur either as a separate tumor, or as a component of CMT consisting of both cortical adenoma cells and pheochromocytoma cells. (upmc.edu)
  • Pheochromocytoma can rarely produce ACTH and a possibility exists that this ectopic ACTH production might initiate the cortical adenoma component of this tumor. (upmc.edu)
  • Ohta TI, Motoyama T, Imai T, Komeyama T, Watanabe H. Cortio-medullary mixed tumor (Pheochromocytoma and cortical adenoma) of the adrenal gland. (upmc.edu)
  • Aiba M, Hirayama A, Ito Y, Fujimoto Y, Nakagami y, Demura H, and Shizume K A compound adrenal medullary tumor (Pheochromocytoma and Ganglioneuroma) and a cortical adenoma in the ipsilateral adrenal gland. (upmc.edu)
  • We first demonstrated that in human adrenal cortex, cells proliferate in the outer zona fasciculata and die as an apoptosis in the zonal reticularis and glomerulosa, consistent with 'cell migration' or considered to play important roles in tumor cell dynamics in adrenocortical neoplasms. (nii.ac.jp)
  • We performed WES for 8 cases with corticotropin-independent Cushing’s syndrome, in whom paired tumor and normal DNA was obtained from fresh frozen adenomas and either normal adrenal tissues or peripheral blood, respectively. (ebi.ac.uk)
  • Tumor DNA was extracted from adrenocortical adenomas and normal DNA was extracted from adjacent adrenal tissues or periphral blood. (ebi.ac.uk)
  • hepatocellular adenoma a large, fleshy, hypervascular tumor of the liver occurring chiefly in women of childbearing age and associated with oral contraceptive use. (thefreedictionary.com)
  • The most common adrenocortical tumor is a benign adenoma or "incidentaloma," which is nonfunctional. (clinicaladvisor.com)
  • Are you sure your patient has an adrenocortical tumor? (clinicaladvisor.com)
  • The patients underwent adrenalectomy, and histology identified adrenocortical adenomas with widespread myelolipomatous metaplasia. (medscape.com)
  • Hyperparathyroidism can be useful in the identification of primary aldosteronism due to aldosterone-producing adenoma. (medscape.com)
  • TGF-alpha expression was detected at both protein and mRNA levels in normal and neoplastic adrenals but not EGF.EGFR immunoreactivity was more widely distributed than TGF-alpha immunoreactivity, TGF-alpha and EGF was considered to be involved in biological function including adrenocortical malignancy. (nii.ac.jp)
  • Adrenocortical adenomas and malignancy are discussed elsewhere. (renalandurologynews.com)
  • However, adrenal mass activity, which is visibly lower than liver activity, is more specific for adenoma, whereas adrenal mass activity visibly greater than liver activity is more specific for malignancy. (appliedradiology.com)
  • In all cases, but especially in the setting of known current or previous malignancy, adrenal adenomas need to be distinguished from adrenal metastases or other adrenal malignancies. (radiopaedia.org)
  • METHODS AND RESULTS: We examined 22 benign and 17 malignant adrenocortical tumours and compared IGFII and CDK4 expression with known immunohistochemical as well as morphological criteria of malignancy. (uzh.ch)
  • CONCLUSIONS: IGFII and MIB1 are helpful immunohistochemical markers to predict malignancy in adrenocortical neoplasms. (uzh.ch)
  • Though no definitive test can distinguish between adenoma and malignancy, imaging is the most useful modality, with computed tomography (CT) being the preferred imaging test. (oncologynurseadvisor.com)
  • Very occasionally, a true adrenal cortical adenoma is associated with the clinical manifestations of Conn's syndrome, and can be shown to be excreting mineralocorticoids. (worldlibrary.net)
  • We report a case of PA due to adrenocortical adenoma (Conn's syndrome) coexisting with Graves' disease in the same patient and review the available literature in view of identifying possible associations. (hindawi.com)
  • ACTH-secreting adenoma ( adrenocorticotrophic hormone-secreting adenoma ) corticotroph adenoma . (thefreedictionary.com)
  • Called also ACTH-secreting or adrenocorticotropic hormone-secreting adenoma and corticotropinoma . (thefreedictionary.com)
  • Possible mutations in p53 and ACTH-R genes were screened in benign adrenocortical adenomas producing cortisol. (nii.ac.jp)
  • Immunohistochemical stains for chromogranin (IMAGE 06 ), synaptophysin (IMAGE 07 ) and neuron specific enolase (IMAGE 08 ) are positive for the pheochromocytoma cells, and negative for the cortical adenoma cells. (upmc.edu)
  • In addition, review of the literature demonstrates that the pheochromocytoma and cortical adenoma components of CMT are easily distinguished by the antibody to the mitochondrial antigen 113-1. (upmc.edu)
  • All cortical adenoma cells showed strong and diffuse reactivity for this antibody, while pheochromocytoma cells only showed very weak reactivity (1). (upmc.edu)
  • Rare cases of pheochromocytoma can arise in association with cortical adenoma. (upmc.edu)
  • The question of whether the cortical adenoma and pheochromocytoma components of CMT grow independently, or their growth is interrelated is difficult to resolve. (upmc.edu)
  • Miyazawa K, Kigoshi T, Nakano S, Kobayashi Y, Suzuki K, Tsugawa R, and Uchida K Hypertension due to coexisting pheochromocytoma and aldosterone producing adrenal cortical adenoma. (upmc.edu)
  • Slapa RZ, Jakubowski W, Feltynowski T, and Januszewicz A. Multiple adrenal masses: MRI tissue differentiation of pheochromocytoma and adenoma at 1.5 T. Eur Radiol. (upmc.edu)
  • Though adrenocortical adenomas are considered challenging to differentiate from the normal adrenal cortex, they appear as well-circumscribed lesions once isolated. (wikipedia.org)
  • The majority of these lesions are benign adrenocortical adenomas (80%), characterized in 10-40% of the cases by autonomous cortisol hypersecretion, and in 1-10% by aldosterone hypersecretion. (nih.gov)
  • Histopathology confirmed that all 66 adrenal masses with imaging characteristics suggesting benign adenoma were indeed benign lesions and included 61 benign adrenal adenomas and 5 benign nonadenomatous lesions (3 myelolipomas, 1 composite myelolipoma/adenoma, and 1 ganglioliponeuroma). (medscape.com)
  • Pathologically, 2 of the lesions were classified as adrenocortical neoplasms of uncertain malignant potential, and 1 lesion was classified as an adrenocortical adenoma. (medscape.com)
  • While no abnormality was detected in proximal GIPR promoter methylation, we identified somatic duplications in chromosome region 19q13.32 containing the GIPR locus in the adrenocortical lesions derived from 3 patients. (jci.org)
  • Among hormone-producing lesions, besides pheochromocytomas, cortisol-producing and aldosterone-producing adenomas (CPAs and APAs) of the adrenal cortex are frequently diagnosed ( 2 ). (frontiersin.org)
  • 1 Use of contrast enhancement washout values would help to further distinguish adenomas from malignant lesions. (appliedradiology.com)
  • Adrenal adenomas are the most common adrenal lesions, found in 3% of cases at autopsy. (appliedradiology.com)
  • Imaging plays a key role in assessing the vast number of incidental adrenal lesions, the majority of which are adrenal adenomas. (radiopaedia.org)
  • On evaluation of persistent hypokalemia and hypertension, primary hyperaldosteronism due to right-sided adrenal adenoma was diagnosed. (hindawi.com)
  • Background: Subclinical Cushing s syndrome (SCS) due to incidentally discovered adrenal adenomas (AI) has been associated with increased prevalence of hypertension, obesity, and impaired glucose tolerance which are established risk factors for cardiovascular morbidity. (endocrine-abstracts.org)
  • To evaluate the feasibility, safety, and therapeutic effects of retroperitoneoscopic-guided cool-tip radiofrequency ablation (RCRFA) used for the treatment of adrenocortical adenoma with Cushing syndrome. (auanet.org)
  • From May 2006 to May 2009, 12 female patients with adrenocortical adenoma and Cushing syndrome underwent RCRFA. (auanet.org)
  • Using RCRFA for adrenocortical adenoma with Cushing syndrome is a feasible, safe, and promising treatment method in selected patients. (auanet.org)
  • The aim of the study is to present genes encoding enzymatic proteins of aldosterone and cortisol synthesis pathway, methods of their transcriptional activity measurement, mRNA expression of the genes in normal adrenal cortex, in adrenocortical adenomas excised from patients with Conn and Cushing syndromes, as well as in adrenocortical adenomas excised from patients, in which hormonal activity of the tumour was not confirmed. (viamedica.pl)
  • The most common disease states caused by functioning adenomas are Cushing syndrome (due to excess cortisol production), Conn syndrome (due to excess aldosterone production) or sex hormone-related symptoms 4 . (radiopaedia.org)
  • Adrenocortical carcinomas and adenomas can be hard to tell apart. (brainscape.com)
  • This slide show features adrenocortical carcinomas and adenomas, and various pheochromocytomas at different magnifications. (cancernetwork.com)
  • Through these studies, the cyclic AMP-dependent protein kinase A signaling has been identified as a key mediator of cortisol secretion, and the mutations associated with the dysregulation of cyclic AMP - protein kinase A pathways have been implicated in the adrenocortical pathophysiology. (wikipedia.org)
  • Somatic mutations in protein kinase A catalytic α subunit (PRKACA) were found to be causative for 30-40% of cortisol-producing adenomas (CPA) of the adrenal gland, rendering PKA signalling constitutively active. (uni-wuerzburg.de)
  • The association of pathological features of cortisol-producing adrenocortical adenomas ACAs with somatic driver mutations and their molecular classification remain unclear. (duhnnae.com)
  • Somatic mutations in KCNJ5 also occur in sporadic aldosterone producing adenomas (APA). (elsevier.com)
  • Objective: The objective of the study was to define the effect of the KCNJ5 mutations on gene expression and aldosterone production using APA tissue and human adrenocortical cells. (elsevier.com)
  • K+ channel mutations in adrenal aldosterone-producing adenomas and hereditary hypertension. (medscape.com)
  • In these cases, affected people usually have multiple adenomas and other characteristic features of the condition that are all caused by changes ( mutations ) in a gene . (nih.gov)
  • Activating somatic mutations in the β-catenin gene have been implicated in a number of benign adenomas as well as adrenal carcinomas. (clinicaladvisor.com)
  • Montone et al presented pathologic and radiographic features of 3 patients with adrenocortical neoplasms. (medscape.com)
  • however, in a few cases, bilateral functional adrenocortical adenomas cause spontaneous disease , and thrombotic events are considered uncommon complications . (bvsalud.org)
  • Diseases associated with SULT2A1 include Sex Differentiation Disease and Adrenal Cortical Adenoma . (genecards.org)
  • However, the patient in our case presented with only atypical hypertension, and her stimulated cortisol and aldosterone levels were within normal limits, which demonstrated that the component of cortical adenoma of the CMT was nonfunctioning. (upmc.edu)
  • In clinical practice, patients with unexplained osteoporosis, particularly when associated with other features such as impaired glucose tolerance or hypertension, should be investigated for the possible presence of autonomous cortisol or aldosterone secretion due to an adrenal adenoma. (nih.gov)
  • Benign cortisol-secreting adenomas can also produce small amounts of androgens (steroid hormones, such as testosterone), although androgen levels in the blood are usually not elevated. (nih.gov)
  • Approximately 60% of adrenocortical carcinomas are functional and can produce androgens, cortisol, or both. (clinicaladvisor.com)
  • Excess production of androgens from adrenal adenomas is rare, but can occur. (oncologynurseadvisor.com)
  • Immunohistochemistry with a panel of steroidogenic dehydrogenases and hydroxylases was positive in the large cells, confirming these as adrenocortical cells. (elsevier.com)
  • The combination of IGFII immunohistochemistry with MIB1 index led to high sensitivity and specificity in detecting adrenocortical carcinomas. (uzh.ch)
  • Functional adrenocortical adenomas demonstrate symptoms consistent with mixed endocrine syndromes. (wikipedia.org)
  • If functional, adrenocortical adenomas can affect the normal activities of the adrenal cortex. (wikipedia.org)
  • Hence, functional adrenocortical adenomas can induce over-secretion of adrenal steroids associated with pure or mixed endocrine syndromes, a condition commonly known as hyperadrenalism. (wikipedia.org)
  • Are most adrenocortical adenomas functional or non-functional? (brainscape.com)
  • Are most adrenocortical carcinomas more likely to be functional? (brainscape.com)
  • Though the majority are clinically silent, functional adenomas from either the cortex of medulla can lead to overproduction of any of their associated hormones. (oncologynurseadvisor.com)
  • The primary hormone found in excess, as many adenomas arise from a discrete zone of the adrenal cortex and may overproduce a single hormone, delineates these syndromes. (oncologynurseadvisor.com)
  • Corticosteroids are administered in physiologic dosages to replace deficient endogenous hormones in patients with adrenocortical insufficiency. (drugs.com)
  • Patients with hyperfunctioning adrenal gland adenomas present with manifestations of excess hormone secretion. (radiopaedia.org)
  • Differences in gene expression were also identified between adrenocortical adenomas and carcinomas. (stjuderesearch.org)
  • In addition, pediatric adrenocortical carcinomas were found to share similar patterns of gene expression when compared with those published for adult ACT. (stjuderesearch.org)
  • What is the most common presentation of adrenocortical tumours? (brainscape.com)
  • Genetics of adrenocortical tumours. (urotoday.com)
  • Adenomas derived from the medulla of the adrenal gland are called pheochromocytomas and may result in overproduction of one or both catecholamines. (oncologynurseadvisor.com)
  • Methods: Next-generation sequencing (NGS) on 30 formalin-fixed paraffin-embedded archived tissue samples (discovery cohort: 10 adrenocortical adenoma (ACA), 10 ACC and 10 myelolipoma) was performed by Illumina MiSeq. (omicsdi.org)
  • Lipid-poor adenomas are more difficult to diagnose because the CT density increases and approaches that of soft tissue. (radiopaedia.org)
  • The aim of this report was to describe a case of bilateral adrenocortical adenoma in a dog with hyperadrenocorticism associated with distal aortic and iliac thrombosis , with emphasis on clinical and pathological aspects. (bvsalud.org)
  • Hence, they have earned the title incidentaloma referring to small adenoma discovered incidentally. (wikipedia.org)
  • The term incidental adrenal lesion (also colloquially known as an incidentaloma ) is sometimes used interchangeably with adrenal adenoma, although in truth an incidental adrenal lesion includes all pathologies (including malignancies). (radiopaedia.org)
  • nonsecreting adenoma ( nonsecretory adenoma ) endocrine-inactive adenoma . (thefreedictionary.com)
  • some contain hormone-secreting cells ( endocrine-active adenomas ) but some are not secretory ( endocrine-inactive adenomas ) . (thefreedictionary.com)
  • see prolactinoma , corticotroph adenoma , gonadotroph adenoma , growth hormone-secreting adenoma , and thyrotroph adenoma . (thefreedictionary.com)
  • eosinophilic adenoma growth hormone-secreting adenoma . (thefreedictionary.com)
  • plurihormonal adenoma an endocrine-active adenoma that secretes more than one kind of hormone. (thefreedictionary.com)
  • Adrenocortical adenoma is commonly described as a benign neoplasm emerging from the cells that comprise the adrenal cortex. (wikipedia.org)
  • A higher SUVmax showed a clear black adenoma appearance with predominantly compact cells, which exhibited high T1 and T2 signals, a lack of signal drop on out-of-phase imaging on MRI, and less accumulation on 131 -I adsterol scintigraphy. (bioscientifica.com)
  • Two theories are considered, as were proposed by the authors of the previous case report regarding the same entity (10), i.e., 1) the possibility of misplaced embryonic adrenocortical cells and 2) the presence of uncommitted stem cells that differentiate into adrenocortical cells. (elsevier.com)
  • Feig, Denice S. / A composite silent corticotroph pituitary adenoma with interspersed adrenocortical cells : Case report . (elsevier.com)
  • Cortical adenoma cells have clear cytoplasm (IMAGE 03 ). (upmc.edu)
  • Histological evaluation revealed a well-differentiated neoplastic proliferation of cortical epithelial cells , consistent with bilateral adenoma , and muscular necrosis in the pelvic limbs was also observed. (bvsalud.org)
  • In the upper right quadrant of the cortex is a dark blue nodule that is an adrenal cortical adenoma since it does not stain brown, is located within the adrenal cortex, and has cellular features consistent with the cortical cells. (jax.org)
  • We demonstrated that juxtaposition with cis-acting regulatory sequences such as glucocorticoid response elements in the newly identified genomic environment drives abnormal expression of the translocated GIPR allele in adenoma cells. (jci.org)
  • The pathophysiology of aldosterone-producing adenomas (APA) has been investigated intensively through genetic and genomic approaches. (cancerindex.org)