Inactivation of catecholamines by superoxide gives new insights on the pathogenesis of septic shock. (1/19)A major feature of septic shock is the development of a vascular crisis characterized by nonresponsiveness to sympathetic vasoconstrictor agents and the subsequent irreversible fall in blood pressure. In addition, sepsis, like other inflammatory conditions, results in a large increase in the production of free radicals, including superoxide anions (O(2)) within the body. Here we show that O(2) reacts with catecholamines deactivating them in vitro. Moreover, this deactivation would appear to account for the hyporeactivity to exogenous catecholamines observed in sepsis, because administration of a superoxide dismutase (SOD) mimetic to a rat model of septic shock to remove excess O(2) restored the vasopressor responses to norepinephrine. This treatment with the SOD mimetic also reversed the hypotension in these animals; suggesting that deactivation of endogenous norepinephrine by O(2) contributes significantly to this aspect of the vascular crisis. Indeed, the plasma concentrations of both norepinephrine and epinephrine in septic rats treated with the SOD mimetic were significantly higher than in untreated rats. Interestingly, the plasma concentrations for norepinephrine and epinephrine were inversely related to the plasma concentrations of adrenochromes, the product of the autoxidation of catecholamines initiated by O(2). We propose, therefore, that the use of a SOD mimetic represents a new paradigm for the treatment of septic shock. By removing O(2), exogenous and endogenous catecholamines are protected from autoxidation. As a result, both hyporeactivity and hypotension are reversed, generation of potentially toxic adrenochromes is reduced, and survival rate is improved. (+info)
Spectroscopic detection of adrenaline-quinone formation in micelles. (2/19)Spectral changes, from 200 nm to 600 nm, of the oxidation of adrenaline to adrenochrome induced by periodate in electrically charged and neutral micelles at pH 3.77 were studied. The observed variations of the peak position, intensity and shape of the fluorescence spectra indicated that depending on the charge of the micelle adrenaline ion is partially embedded into the micellar core. Fluorescence lifetime measurements using Omnilyzer allowed to calculate partition coefficients of 0.36, 0.05 and 0.01 in sodium dodecyl sulphate, tetradodecyltrimethylammonium bromide and Triton X-100, respectively. Kinetics of adrenaline decay during oxidation were followed by its fluorescence what overcame spectral interference in the absorption spectra of adrenaline from the formed intermediates. Scanning absorption spectroscopy, with 100 ms resolution, allowed the recording of spectral changes during the transformation. With this method, the formation of adrenaline-quinone with absorption maxima at 388 nm and 274 nm was detected. The calculated rate constants of the observed kinetics during oxidation were significantly lowered in both charged micelles compared to buffer solution and in Triton X-100 neutral micelles. The observed phenomena are discussed in terms of the electrostatic forces mechanism and in the frame of the Raper-Mason scheme of adrenaline transformation. (+info)
The fallacy of using adrenochrome reaction for measurement of reactive oxygen species formed during cytochrome p450-mediated metabolism of xenobiotics. (3/19)The adrenochrome reaction (oxidation of epinephrine to adrenochrome) has been widely employed as a standard assay for reactive oxygen species, produced under a variety of conditions, including those produced during cytochrome P450 (CYP)-mediated oxidation of substrates such as cyclosporine. However, it has been reported that epinephrine and adrenochrome can be metabolized by hepatic microsomes and that adrenochrome can also be metabolized by NADPH-CYP reductase. Thus, in the present report, we provide evidence that measurement of adrenochrome cannot be used as an index of reactive oxygen species generated during CYP-mediated metabolism of xenobiotics because adrenochrome and its precursor, epinephrine, interact with the CYP enzyme system as substrates and inhibitors. Our results indicated that adrenochrome was moderately stable in phosphate buffer but degraded rapidly (over 50% consumed in less than 2 min) by (cloned and expressed) CYP3A4 and CYP reductase in the presence of NADPH. Furthermore, both epinephrine and adrenochrome were found to be inhibitors of CYP3A4-mediated oxidation of testosterone. Together, these results lead to the conclusion that the use of adrenochrome reaction for measurement of reactive oxygen species formed during CYP3A4-mediated metabolism of xenobiotics is inappropriate. (+info)
Quinone reductase 2 is a catechol quinone reductase. (4/19)(+info)
Generation of the superoxide radical during autoxidation of oxymyoglobin. (5/19)Autoxidation of bovine oxymyoglobin to metmyoglobin induces co-oxidation of epinephrine to adrenochrome. This co-oxidation is markedly inhibited by superoxide dismutase [EC 18.104.22.168]. Electron transfer from oxymyoglobin to ferricytochrome c is partially inhibited by superoxide dismutase. These results indicate that autoxidation of oxymyoglobin results in generation of superoxide radicals. Autoxidation of oxymyoglobin is accelerated by superoxide dismutase and partially inhibited by catalase [EC 22.214.171.124]. (+info)
Rapid methods for high-throughput detection of sulfoxides. (6/19)(+info)
Effect of furosemide and furosemide-carbazochrome combination on exercise-induced pulmonary hemorrhage in Standardbred racehorses. (7/19)The objective was to quantify the effect of furosemide and carbazochrome on exercise-induced pulmonary hemorrhage (EIPH) in Standardbred horses using red blood cell count and hemoglobin concentration in bronchoalveolar lavage (BAL) fluid. Six healthy Standardbred horses with prior evidence of EIPH performed a standardized treadmill test 4 h after administration of placebo, furosemide, or furosemide-carbazochrome combination. Red blood cell (RBC) counts and hemoglobin concentrations were determined on the BAL fluid. The RBC count in BAL ranges were (2903-26,025 cells/microL), (45-24,060 cells/microL), and (905-3045 cells/microL) for placebo, furosemide, and furosemide-carbazochrome, respectively. Hemoglobin concentration ranges were (0.03-0.59 mg/mL), (0.01-0.55 mg/mL), and (0.007-0.16 mg/mL) for placebo, furosemide, and furosemide-carbazochrome groups, respectively. No significant differences were detected among treatments. However, there was great variability among horses, suggesting that a larger sample size or better selection of horses was needed. (+info)
Free radical signalling underlies inhibition of CaV3.2 T-type calcium channels by nitrous oxide in the pain pathway. (8/19)(+info)
The adrenochrome theory of schizophrenia waned, despite some evidence that it may be psychotomimetic, as adrenochrome was not ... Adrenochrome Commentary at erowid.org Adrenochrome deposits resulting from the use of epinephrine-containing eye drops used to ... using the adrenochrome they "harvest" from their victims' blood as a drug or as an elixir of youth. In reality, adrenochrome ... as pure adrenochrome is deep violet. The oxidation reaction that converts adrenaline into adrenochrome occurs both in vivo and ...
Appetite for Adrenochrome
"Groovie Ghoulies - Appetite For Adrenochrome [Reissue]". www.punknews.org. "Groovie Ghoulies: Appetite For Adrenochrome". Music ... Appetite for Adrenochrome is the debut album by the Sacramento punk rock band the Groovie Ghoulies. It was released in 1989 on ... Appetite for Adrenochrome was remastered and reissued by Lookout! Records in September 1996. This version was re-released by ... A cover of Kiss' 1976 top-ten hit "Beth" appears as an unlisted track at the end of Appetite for Adrenochrome. The Groovie ...
"XP8 presents Adrenochrome". Indiegogo.com. 2013-05-09. Retrieved 2013-05-09. "Interview: XP8". intravenous.co.uk. 2015-02-05. ... In 2013, XP8 released the crowd-funded concept album Adrenochrome, which they described as their best effort to date, without ... Adrenochrome (2013, 2393 Records) RE_Productions (2004, Black Flames Records) Synthphony REMIXed! Vol.4 (2005, Synthphony ...
List of pop-punk albums
"Appetite for Adrenochrome". AllMusic. Retrieved 14 December 2015. Mike DaRonco. "Snuff Said". AllMusic. Retrieved 31 December ...
... "adrenochrome harvest". One version of the QAnon theory posits that the child abusers use adrenochrome as an elixir to remain ... Adrenochrome has become the subject of a number of myths since Hunter S. Thompson mentioned it in his 1971 book Fear and ... Added to this is the belief that politicians and Hollywood elites engage in "adrenochrome harvesting", in which adrenalin is ... Adams J (April 7, 2020). "The truth about adrenochrome". The Spinoff. Retrieved June 28, 2020. "QAnon: A Glossary". Anti- ...
Subsequent research suggested that Hoffer's adrenochrome theory had merit as people with schizophrenia have defects in the ... Hoffer called his theory the "adrenochrome hypothesis". In 1967, Hoffer resigned some of his academic and administrative ... Hoffer, A (1990). "The Adrenochrome Hypothesis and Psychiatry". Retrieved July 25, 2011. "ACS : Orthomolecular Medicine". ... when oxidized to adrenochrome was an endogenous neurotoxin that could cause schizophrenia. At the same time, another Canadian ...
Green DE, Richter D (1937) Adrenaline and adrenochrome. Biochem J 31:596-616 Richter D (1937) Adrenaline and amine oxidase. ...
Liquid Sky (band)
Their first release was the EP Adrenochrome in 2001. In 2002, Emily was replaced by Fiona Creaby and the band subsequently ... Adrenochrome (2001) (Emily Garrard - Vocals) "Liquid Sky". Room 13. "Liquid Sky Biography". Liquid Sky. (Use British English ...
Fear and Loathing in Las Vegas (film)
For ether, Pecorini said they used a "loose depth of field; everything becomes non-defined"; for adrenochrome, "everything gets ... as Duke attempts to mellow out by trying some of Gonzo's stash of adrenochrome. However, the trip spirals out of control, and ...
Examples of the former include the Corey-Chaykovsky reagent and adrenochrome. In biomedical engineering, protein nanogels made ...
"Floorshow" (Eldritch/Adams/Marx) - 3:20 "Lights" (Eldritch) - 5:30 "Teachers/Adrenochrome" (Cohen/Eldritch) - 7:35 Andrew ... ", "Lights" and "Adrenochrome" were later rerecorded and released on singles. The Leonard Cohen cover, "Teachers", remained ...
... it is a derivative of adrenochrome, which is a product of adrenaline oxidation. It is a serotonin antagonist both in vitro and ...
Pizzagate conspiracy theory
Hitt, Tarpley (August 14, 2020). "How QAnon Became Obsessed With 'Adrenochrome,' an Imaginary Drug Hollywood Is 'Harvesting' ... the adrenochrome from their blood, which they then use as a drug or as an elixir to remain youthful. A related conspiracy ... drinking her adrenochrome-rich blood in a Satanic ritual, and "tak[ing] turns wearing the little girl's face like a mask". ...
The Sisters of Mercy
In 1982, the band recorded "The Body Electric" b/w "Adrenochrome" single for the CNT label. The band's singles were regularly ...
Don't Go Out into the Rain (You're Going to Melt)
... for their 1989 album Appetite for Adrenochrome. "spectropop.com". Spectropop.com. Retrieved 4 February 2021. Whitburn, Joel ( ...
Born in the Basement
... from the band's preceding album Appetite for Adrenochrome. Like Appetite for Adrenochrome, Born in the Basement includes five ...
In February 2022, a sculpture of Simon of Trent depicting the blood libel was used to promote the adrenochrome-harvesting ... theory has been accused of advancing blood libel tropes through its belief that Hollywood elites are harvesting adrenochrome ...
Fear and Loathing in Las Vegas
... adrenochrome, and cannabis. This leads to a series of bizarre hallucinogenic experiences, during which they destroy hotel rooms ...
... along with his invention of adrenochrome's psychedelic effects later in the book. Dr. Wilbur Larch, in John Irving's novel The ...
... adrenochrome) which was written during the Covid-19 lockdown. It was also the first record being released by their own record ...
The use of epinephrine based eye-drops, commonly used to treat glaucoma, may also lead to a buildup of adrenochrome pigments in ...
Adrenochrome)" Final: "Hide" Lull: "Thoughts" Thomas Köner: "Kanon (Part One: Brohuk)" Bush, John. "Various Artists - Ambient 4 ...
List of MeSH codes (D03)
... adrenochrome MeSH D03.438.473.050 - alcian blue MeSH D03.438.473.133 - captan MeSH D03.438.473.155 - carbolines MeSH D03.438. ...
The molecular formula C9H9NO3 (molar mass: 179.175 g/mol) may refer to: Acedoben N-Acetylanthranilic acid Adrenochrome Hippuric ...
... ranging from cannabis to amyl nitrite to adrenochrome - in an attempt to keep the spirit of the 1960s, a time which he speaks ...
List of drug films
... adrenochrome) Club Paradise (1986) - cannabis Clubbed to Death (1996) - MDMA Clueless (1995) - cannabis, cocaine Cocaine Bear ( ... adrenochrome Federal Fugitives (1941) - pills Fifty Pills (2006) - MDMA The Final Programme (1973) Flashback (1990) - LSD ...
... that she has abolished utility bills or other debts and has ended adrenochrome extraction in Canada. To effectuate these claims ...
Simon of Trent
... libel was used by QAnon conspiracy theorists to promote the conspiracy theory that Hollywood elites are harvesting adrenochrome ...
A Well Respected Man (Defiance)
... a human lab technician who is harvesting their adrenochrome to use as an illegal drug. Nolan and Amanda confront Datak, who ...
... to Adrenochrome and alleged satanist child abuse. The OCG maintains its own youth organization, the OCG Youth, with its own web ...
The Adrenochrome Crisis | F!Box
The Adrenochrome Crisis Jan 23, 2023 NATO, Vladimir Putin, Volodymyr Zelenskyy, White Hats ... Adrenochrome is said to be endemic to political and Hollywood elites, and recipients claim it prolongs life, wards off illness ... Adrenal fluid is a crucial ingredient of Adrenochrome.. An FSB agent named Andrei Zakharov told Real Raw News that one of the ... Zakharov claims Adrenochrome produced in Ukraine is being flown in refrigerated containers to the U.S. and other Western ...
HOLLYWOOD MOVIE STAR EXPOSES ADRENOCHROME & CHILD SEX TRAFFICKING - Philosophers Stone
Child Adrenochrome: Globalist Cabal's Immortality Drug of Choice - PARADIGM SHYFT
What is Adrenochrome?. Adrenochrome is the powerful hormonal precursor for adrenaline secreted by the body in large amounts in ... Science of Adrenochrome. While much of the clinical testing and conclusions of published research surrounding adrenochrome, ... driven by adrenochrome frenzy among the world elite always frantically working to avoid the ravages of adrenochrome withdrawal. ... adrenochromeAwakeningAwarenessCabalcelebritieschild abuseChild sacrificefree choicefreemasonHarvestingHuman BeingsHuman ...
Hollywood Movie Star Exposes Adrenochrome & Child Sex Trafficking - Socio-Economics History Blog
Remember when adrenochrome was a "conspiracy theory?" Now it's conspiracy FACT in the form of "youth
Remember when adrenochrome was a "conspiracy theory?" Now its conspiracy FACT in the form of "youth transplants". ... Remember when adrenochrome was a "conspiracy theory?" Now its conspiracy FACT in the form of "youth. ... But the reality is that youth transplants are akin to the adrenochrome scandal that cropped up during the Trump years.. ... https://www.newstarget.com/2022-06-12-adrenochrome-conspiracy-theory-fact-youth-transplants.html ...
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"Young Blood" - The Emerging Market for Products Made from the Blood of...
ADRENOCHROME The Elites Super Drug (Jay Myers Documentaries), is still available on YouTube here. It is also on Bitchute.com ... How Big is the Illegal Underground Adrenochrome Market?. As we mentioned last year, the knowledge of the black market ... The Marketing of Childrens Blood: Adrenochrome Goes Mainstream on Turkish TV News. While the corporate media in the U.S. would ... We also reported how the drug "adrenochrome," harvested from terrorized young children who produce blasts of adrenalin, ...
Bombshell: The 2020 Election Took Place Under a Trump-Declared "National Emergency" That Set an Election Day Trap for the ...
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- Hallucinogens as hard science: the adrenochrome hypothesis for the biogenesis of schizophrenia. (moleculardepot.com)
- 95%) Adrenochrome, a product of oxidation of adrenaline. (moleculardepot.com)
- Adrenochrome is the powerful hormonal precursor for adrenaline secreted by the body in large amounts in moments of intense fear, anger or perceived life threatening danger. (paradigmshyft.com)
- While much of the clinical testing and conclusions of published research surrounding adrenochrome, also known as "Pink Adrenaline," or oxidized adrenaline, has been hidden from public view, a number of published studies quantifying the basic properties and capabilities of the substance are in the public domain. (paradigmshyft.com)
- In a 1939 study, perfusion of adrenochrome was found to regenerate and restart a frog's heart, bringing the animal back to life and making adrenaline/epinephrine application in heart attack patients standard of care to this very moment. (paradigmshyft.com)
- What's more, repeated overexposure to adult adrenochrome oxidized adrenaline leads to nefarious mental and physical side effects including epileptic seizure, Parksinsonian symptoms, schizophrenia and delusional psychosis. (paradigmshyft.com)
- We also reported how the drug "adrenochrome," harvested from terrorized young children who produce blasts of adrenalin, including children murdered in Satanic Ritual Abuse, was beginning to get mainstream media coverage outside the U.S. back in 2020. (healthimpactnews.com)
- Effects of adrenochrome on calcium accumulating and adenosine triphosphatase activities of the rat heart microsomes. (moleculardepot.com)
- Equal parts spa treatment and party drug, news of the regenerative powers of adrenochrome spread quickly among the world scientific community and the global elite, sparking massive demand for the recreational use of the substance, regardless of manner of extraction, by the rich, powerful and scandalously wealthy who remain perpetually obsessed with finding ways of extending lifespan and prolonging their grasp on earthly influence and pleasure. (paradigmshyft.com)
- Drinking the blood of children that contains adrenochrome is the drug these satanist famous people and politicians have been involved with for decades. (fourwinds10.com)
- He talks about the horror of adrenochrome and child trafficking. (philosophers-stone.info)
- Adrenochrome harvest and acquisition is the WHY of everything else in the emerging and pernicious realm of unspeakable acts of child sex trafficking, abduction, abuse exploitation and even child sacrifice by the world elite. (paradigmshyft.com)
- While the corporate media in the U.S. would like to ignore and censor anything related to adrenochrome, "young blood" is a concept that they apparently want to bring mainstream and condition the public to accept. (healthimpactnews.com)
- Very quickly, scientists discovered the power of adrenochrome to turn back the clock in restoring youthful function of the human body, especially nervous system and glandular functions that determine the rapidity of the aging process. (paradigmshyft.com)
- In one noted Belgian study published in 1946, clinicians were able to use a perfusion of aqueous adrenochrome to bring an intentionally frostbitten rabbit's ear back to life with only a few exposures, allowing doctors to restore vascularity and nerve stimulus response to previously necrotized tissue. (paradigmshyft.com)
- This red substance is a pigment called adrenochrome. (medscape.com)