Adrenergic Uptake Inhibitors
Drugs that block the transport of adrenergic transmitters into axon terminals or into storage vesicles within terminals. The tricyclic antidepressants (ANTIDEPRESSIVE AGENTS, TRICYCLIC) and amphetamines are among the therapeutically important drugs that may act via inhibition of adrenergic transport. Many of these drugs also block transport of serotonin.
Neurotransmitter Uptake Inhibitors
Drugs that inhibit the transport of neurotransmitters into axon terminals or into storage vesicles within terminals. For many transmitters, uptake determines the time course of transmitter action so inhibiting uptake prolongs the activity of the transmitter. Blocking uptake may also deplete available transmitter stores. Many clinically important drugs are uptake inhibitors although the indirect reactions of the brain rather than the acute block of uptake itself is often responsible for the therapeutic effects.
Dopamine Uptake Inhibitors
Benztropine
GABA Uptake Inhibitors
Nomifensine
An isoquinoline derivative that prevents dopamine reuptake into synaptosomes. The maleate was formerly used in the treatment of depression. It was withdrawn worldwide in 1986 due to the risk of acute hemolytic anemia with intravascular hemolysis resulting from its use. In some cases, renal failure also developed. (From Martindale, The Extra Pharmacopoeia, 30th ed, p266)
Zimeldine
Serotonin Uptake Inhibitors
Desipramine
A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine from the neural synapse, and also appears to impair serotonin transport. This compound also possesses minor anticholinergic activity, through its affinity to muscarinic receptors.
Serotonin
A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily in the central nervous system, gastrointestinal tract, and blood platelets. Serotonin mediates several important physiological functions including neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity. Multiple receptor families (RECEPTORS, SEROTONIN) explain the broad physiological actions and distribution of this biochemical mediator.
Cocaine
An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat. It also has powerful central nervous system effects similar to the amphetamines and is a drug of abuse. Cocaine, like amphetamines, acts by multiple mechanisms on brain catecholaminergic neurons; the mechanism of its reinforcing effects is thought to involve inhibition of dopamine uptake.
Clomipramine
Dopamine Plasma Membrane Transport Proteins
Serotonin Antagonists
Mazindol
Dopamine
One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and EPINEPHRINE. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (RECEPTORS, DOPAMINE) mediate its action.
Protriptyline
Metergoline
Fenfluramine
Quipazine
Amphetamines
Biogenic Monoamines
Fluvoxamine
Fluoxetine
Dose-Response Relationship, Drug
Imipramine
Norepinephrine Plasma Membrane Transport Proteins
Sodium chloride-dependent neurotransmitter symporters located primarily on the PLASMA MEMBRANE of noradrenergic neurons. They remove NOREPINEPHRINE from the EXTRACELLULAR SPACE by high affinity reuptake into PRESYNAPTIC TERMINALS. It regulates signal amplitude and duration at noradrenergic synapses and is the target of ADRENERGIC UPTAKE INHIBITORS.
Membrane Transport Proteins
Norepinephrine
Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic.
Rats, Sprague-Dawley
Biological Transport
Citalopram
A furancarbonitrile that is one of the SEROTONIN UPTAKE INHIBITORS used as an antidepressant. The drug is also effective in reducing ethanol uptake in alcoholics and is used in depressed patients who also suffer from tardive dyskinesia in preference to tricyclic antidepressants, which aggravate this condition.
Serotonin Plasma Membrane Transport Proteins
Sodium chloride-dependent neurotransmitter symporters located primarily on the PLASMA MEMBRANE of serotonergic neurons. They are different than SEROTONIN RECEPTORS, which signal cellular responses to SEROTONIN. They remove SEROTONIN from the EXTRACELLULAR SPACE by high affinity reuptake into PRESYNAPTIC TERMINALS. Regulates signal amplitude and duration at serotonergic synapses and is the site of action of the SEROTONIN UPTAKE INHIBITORS.
Dipyridamole
N-Methyl-3,4-methylenedioxyamphetamine
Adenosine
Microdialysis
Receptors, Serotonin
2-Chloroadenosine
Monoamine Oxidase Inhibitors
Tyramine
An indirect sympathomimetic. Tyramine does not directly activate adrenergic receptors, but it can serve as a substrate for adrenergic uptake systems and monoamine oxidase so it prolongs the actions of adrenergic transmitters. It also provokes transmitter release from adrenergic terminals. Tyramine may be a neurotransmitter in some invertebrate nervous systems.
Drug Interactions
Synaptosomes
Endocannabinoids
Cannabinoid Receptor Modulators
Polyunsaturated Alkamides
Amides composed of unsaturated aliphatic FATTY ACIDS linked with AMINES by an amide bond. They are most prominent in ASTERACEAE; PIPERACEAE; and RUTACEAE; and also found in ARISTOLOCHIACEAE; BRASSICACEAE; CONVOLVULACEAE; EUPHORBIACEAE; MENISPERMACEAE; POACEAE; and SOLANACEAE. They are recognized by their pungent taste and for causing numbing and salivation.
Fas/CD95/Apo-I activates the acidic sphingomyelinase via caspases. (1/489)
Fas/CD95/Apo-I has been shown to stimulate a variety of molecules including several members of the caspase family and the acidic sphingomyelinase (Martin and Green 1995; Gulbins et al, 1995). Here, we demonstrate that Fas receptor-triggered activation of the acidic sphingomyelinase, consumption of sphingomyelin, release of ceramide, and subsequent activation of JNK and p38-K are regulated by caspases. Inhibition of caspases by Ac-YVAD-chloromethylketone or transient CrmA transfection prevented stimulation of acidic sphingomyelinase, release of ceramide and activation of JNK and p38-K upon Fas-receptor crosslinking. Likewise, Fas triggered apoptosis was almost completely blocked by Ac-YVAD-chloromethylketone or CrmA mediated inhibition of caspases. The results suggest a new signalling cascade from the Fas receptor via caspases to acidic sphingomyelinase, ceramide and JNK/p38-K. (+info)Effects of imipramine, an uptake inhibitor, on double-peaked constrictor responses to periarterial nerve stimulation in isolated, perfused canine splenic arteries. (2/489)
Using a cannula insertion method, periarterial nerve electrical stimulations were performed at 1 and 10 Hz in the isolated, perfused canine splenic artery. Electrical nerve stimulation readily caused double-peaked vasoconstrictions. The 1st-peak response at 1 Hz was not influenced by treatment with imipramine but the 2nd one was significantly enhanced by it. The 2nd-peak response was markedly blocked by prazosin. An additional treatment with alpha,beta-methylene ATP, a P2X-purinoceptor desensitizer, abolished electrical stimulation-induced vascular responses that remained. At 10 Hz, the responses to electrical stimulation were not significantly influenced by imipramine. On the other hand, the imipramine treatment inhibited the tyramine-induced vasoconstriction but potentiated the noradrenaline-induced one. ATP-induced responses were not modified by imipramine. From these results, it is concluded that 1) the 1st-peaked constriction is mainly due to a P2X-purinoceptor-dependent mechanism, 2) the 2nd one is mainly due to an alpha1-adrenoceptor-dependent mechanism, and 3) presynaptic uptake mechanisms may perform an important role in the regulation of vascular reactivity, especially at a low frequency. (+info)Transmembrane domain I contributes to the permeation pathway for serotonin and ions in the serotonin transporter. (3/489)
Mutation of a conserved Asp (D98) in the rat serotonin (5HT) transporter (rSERT) to Glu (D98E) led to decreased 5HT transport capacity, diminished coupling to extracellular Na+ and Cl-, and a selective loss of antagonist potencies (cocaine, imipramine, and citalopram but not paroxetine or mazindol) with no change in 5HT Km value. D98E, which extends the acidic side chain by one carbon, affected the rank-order potency of substrate analogs for inhibition of 5HT transport, selectively increasing the potency of two analogs with shorter alkylamine side chains, gramine, and dihydroxybenzylamine. D98E also increased the efficacy of gramine relative to 5HT for inducing substrate-activated currents in Xenopus laevis oocytes, but these currents were noticeably dependent on extracellular medium acidification. I-V profiles for substrate-independent and -dependent currents indicated that the mutation selectively impacts ion permeation coupled to 5HT occupancy. The ability of the D98E mutant to modulate selective aspects of substrate recognition, to perturb ion dependence as well as modify substrate-induced currents, suggests that transmembrane domain I plays a critical role in defining the permeation pathway of biogenic amine transporters. (+info)Diurnal variation in 5-HT1B autoreceptor function in the anterior hypothalamus in vivo: effect of chronic antidepressant drug treatment. (4/489)
1. Intracerebral microdialysis was used to examine the function of the terminal 5-hydroxytryptamine (5-HT) autoreceptor in the anterior hypothalamus of anaesthetized rats at two points in the light phase of the light-dark cycle. 2. Infusion of the 5-HT1A/1B agonist 5-methoxy-3-(1,2,3,6-tetrahydro-4-pyridyl)-1H-indole (RU24969) 0.1, 1.0 and 10 microM through the microdialysis probe led to a concentration-dependent decrease (49, 56 and 65% respectively) in 5-HT output. The effect of RU24969 (1 and 5 microM) was prevented by concurrent infusion of methiothepin (1 and 10 microM) into the anterior hypothalamus via the microdialysis probe. Infusion of methiothepin alone (1.0 and 10 microM) increased (15 and 142% respectively) 5-HT output. 3. Infusion of RU24969 (5 microM) through the probe at mid-light and end-light resulted in a quantitatively greater decrease in 5-HT output at end-light compared with mid-light. 4. Following treatment with either paroxetine hydrochloride (10 mg kg(-1) i.p.) or desipramine hydrochloride (10 mg kg)(-1) i.p.) for 21 days the function of the terminal 5-HT1B autoreceptor was more markedly attenuated at end-light. 5. The data show that, as defined by the response to RU24969, the function of the 5-HT1B receptors that control 5-HT output in the anterior hypothalamus is attenuated following chronic desipramine or paroxetine treatment in a time-of-day-dependent manner. (+info)Endothelium is required in the vascular spasm induced by tetraethylammonium and endothelin-1 in guinea-pig aorta. (5/489)
1. To investigate the role of endothelium in vascular spasm, we studied the influence of endothelin-1 (ET-1) on the contracting and spasmogenic effect of the K+-channel blocker, tetraethylammonium (TEA), in aorta rings of reserpine-treated guinea-pigs, perfused with either control (5.5 mM) or elevated (50 mM) glucose concentration. 2. Endothelium-dependent relaxation induced by acetylcholine was lost in rings contracted by noradrenaline in the presence of elevated glucose. In control medium, TEA (1-20 mM) induced a sustained tonic contraction, followed by a phasic spasm, characterized by rhythmic contractions. Elevated glucose, ET-1 (3 nM), or both, reduced the EC50 of TEA-induced tonic contraction, without modifying the maximum contractile effect. 3. In control medium, ET-1 reduced the time before TEA-induced spasm and increased the rate of rhythmic contractions. TEA-induced spasm was abolished by elevated glucose, and restored by ET-1. The spasm induced by TEA and ET-1 was amplified by the ETA antagonist, EMD94246, and suppressed by the ET(A)-ET(B) antagonist, bosentan. In endothelium-denuded vessels incubated with high glucose and ET-1, TEA evoked only a tonic contraction. 4. In control medium, L-NAME (N(G)-nitro-L-arginine methyl ester) abolished TEA-induced rhythmic contractions. L-arginine, but not D-arginine, prevented the effect of L-NAME. In the presence of elevated glucose and ET-1, TEA-induced spasm was not affected by L-NAME, whereas verapamil, indomethacin, metyrapone, glybenclamide or apamin abolished the phasic spasm, unmasking the tonic contracture. 5. In conclusion, endothelium plays a regulatory role in the genesis and maintenance of TEA-induced rhythmic contractions, through the release endothelium derived relaxing factor and vasodilating eicosanoids. (+info)Neuronal uptake affects dynamic characteristics of heart rate response to sympathetic stimulation. (6/489)
Recently, studies in our laboratory involving the use of a Gaussian white noise technique demonstrated that the transfer function from sympathetic stimulation frequency to heart rate (HR) response showed dynamic characteristics of a second-order low-pass filter. However, determinants for the characteristics remain to be established. We examined the effect of an increase in mean sympathetic stimulation frequency and that of a blockade of the neuronal uptake mechanism on the transfer function in anesthetized rabbits. We found that increasing mean sympathetic stimulation frequency from 1 to 4 Hz significantly (P < 0.01) decreased the dynamic gain of the transfer function without affecting other parameters, such as the natural frequency, lag time, or damping coefficient. In contrast, the administration of desipramine (0.3 mg/kg iv), a neuronal uptake blocking agent, significantly (P < 0.01) decreased both the dynamic gain and the natural frequency and prolonged the lag time. These results suggest that the removal rate of norepinephrine at the neuroeffector junction, rather than the amount of available norepinephrine, plays an important role in determining the low-pass filter characteristics of the HR response to sympathetic stimulation. (+info)Decrease in hepatic CYP2C11 mRNA and increase in heme oxygenase activity after intracerebroventricular injection of bacterial endotoxin. (7/489)
We previously reported (Arch. Toxcol. 1998, 72, 492-498) that the differential decrease in the levels of hepatic cytochrome P450 (CYP) isozymes in rats was observed 24 hr after intracerebroventricular (i.c.v.) injection of bacterial lipopolysaccharide (LPS) at the dose ineffective (0.1 microgram) when injected intraperitoneally (i.p.). Among CYP isozymes we examined, the male specific CYP isozyme, CYP2C11 was most severely affected by i.c.v. injection of LPS. In this study, we examined the gene expression of CYP2C11, the total P450 contents, the CYP2C11-dependent activity of imipramine N-demethylase (IMND) and protein of CYP2C11 10 hr after i.c.v. or i.p. injections of LPS. Intracerebroventricular injection of LPS significantly decreased the level of CYP2C11 mRNA (to 63% of saline i.c.v. control), the total P450 contents (to 70% of saline i.c.v. control), the IMND activity (to 74% of saline i.c.v. control), but not protein of CYP2C11 in rat liver. In contrast, i.p. injection of LPS at the same dose as i.c.v. did not significantly affect these parameters. Since CYP is a heme protein, we also measured the activity of heme oxygenase (HO) using the same rat liver microsomes. The HO activity was increased to 166% by i.c.v. injection of LPS and 135% by i.p. injection of LPS compared to corresponding saline control. It is suggested that i.c.v. injection of LPS down-regulates the expression of CYP2C11 at transcriptional level and that both the decrease in CYP2C11 mRNA and the increase in heme degradation may be involved in the decreased level of protein and activity of CYP2C11 by i.c.v. injection of LPS in rat liver. (+info)Activities of trovafloxacin compared with those of other fluoroquinolones against purified topoisomerases and gyrA and grlA mutants of Staphylococcus aureus. (8/489)
Frequencies of mutation to resistance with trovafloxacin and four other quinolones were determined with quinolone-susceptible Staphylococcus aureus RN4220 by a direct plating method. First-step mutants were selected less frequently with trovafloxacin (1.1 x 10(-10) at 2 to 4x the MIC) than with levofloxacin or ciprofloxacin (3.0 x 10(-7) to 3.0 x 10(-8) at 2 to 4x the MIC). Mutants with a change in GrlA (Ser80-->Phe or Tyr) were most commonly selected with trovafloxacin, ciprofloxacin, levofloxacin, or pefloxacin. First-step mutants were difficult to select with sparfloxacin; however, second-step mutants with mutations in gyrA were easily selected when a preexisting mutation in grlA was present. Against 29 S. aureus clinical isolates with known mutations in gyrA and/or grlA, trovafloxacin was the most active quinolone tested (MIC at which 50% of isolates are inhibited [MIC(50)] and MIC(90), 1 and 4 microg/ml, respectively); in comparison, MIC(50)s and MIC(90)s were 32 and 128, 16 and 32, 8 and 32, and 128 and 256 microg/ml for ciprofloxacin, sparfloxacin, levofloxacin, and pefloxacin, respectively. Strains with a mutation in grlA only were generally susceptible to all of the quinolones tested. For mutants with changes in both grlA and gyrA MICs were higher and were generally above the susceptibility breakpoint for ciprofloxacin, sparfloxacin, levofloxacin, and pefloxacin. Addition of reserpine (20 microg/ml) lowered the MICs only of ciprofloxacin fourfold or more for 18 of 29 clinical strains. Topoisomerase IV and DNA gyrase genes were cloned from S. aureus RN4220 and from two mutants with changes in GrlA (Ser80-->Phe and Glu84-->Lys). The enzymes were overexpressed in Escherichia coli GI724, purified, and used in DNA catalytic and cleavage assays that measured the relative potency of each quinolone. Trovafloxacin was at least five times more potent than ciprofloxacin, sparfloxacin, levofloxacin, or pefloxacin in stimulating topoisomerase IV-mediated DNA cleavage. While all of the quinolones were less potent in cleavage assays with the altered topoisomerase IV, trovafloxacin retained its greater potency relative to those of the other quinolones tested. The greater intrinsic potency of trovafloxacin against the lethal topoisomerase IV target in S. aureus contributes to its improved potency against clinical strains of S. aureus that are resistant to other quinolones. (+info)
Selective noradrenaline reuptake inhibitors for schizophrenia New | Cochrane Abstracts
Reversal of tetrabenazine induced depression by selective noradrenaline (norepinephrine) reuptake inhibition | Journal of...
Trends and Advances in Separation and Detection of SSRIs and SNRIs in Biological Matrices
Articaine and epinephrine vs Serotonin/Norepinephrine Reuptake Inhibitors drug - drug interaction
Norepinephrine transporter
Strattera raise blood pressure - First Aid University
Abstract W MP39: SSRI/SNRI Use Is Not Associated With Increased Risk Of Delayed Cerebral Ischemia After Aneurysmal Subarachnoid...
Discussion: Presentations Of ADHD | Guide Writers
Apo-Atomoxetine - Uses, Side Effects, Interactions - Drug Factsheets - C-Health
Riva-Atomoxetine - Uses, Side Effects, Interactions - Canoe.com
bluecare.bcbst.com
Edivoxetine | bet-bromodomain.com
Talopram - Wikipedia
Ask the Experts - Red Hot Mamas
Detailed Information (TTD) -- BIDD
The effects of reboxetine on emotional processing in healthy volunteers: an fMRI study. - SCNi
Adrenergic uptake inhibitor - wikidoc
Design, synthesis, and pharmacological evaluation of phenoxy pyridyl derivatives as dual norepinephrine reuptake inhibitors and...
Antinociceptive Effects of the Serotonin and Noradrenaline Reuptake Inhibitors Milnacipran and Duloxetine on Vincristine...
Milnacipran (Savella®): Basic Information - Simple and Practical Mental Health
Edronax (Reboxetine) drug, Edronax Order
Buy Vandral (Venlafaxine) Online
Buy Senexon (Venlafaxine) Online
Buy cheap Cymbalta online without prescription | Visa & MasterCard accepted
Malegra DXT
Buy Venlafaxina (Venlafaxine) Online Cheap
Buy Venex (Venlafaxine) Online
Buy Benolaxe (Venlafaxine) Online
Eye Care - 4
Buy Nervix (Venlafaxine) Online
Canadian-Pharmacy
Prestiq (Pristiq) Information from Drugs.com
Is it safe to take lexopro while taking venalaxafine?
SNRI-præparater - information til borgere - Medicin.dk
Tuesday1st UK: SSRI / SNRI Antidepressant Statistical Politics: Marginal Trends in Prescribing Change 2004 to 2005
Plus it
Tramadol serotonin withdrawal
Using selective noradrenaline reuptake inhibitors (NRIs) to treat schizophrenia | Cochrane
Use of benzodiazepines and selective serotonin reuptake inhibitors in middle-aged and older adults with anxiety disorders: A...
Clinical and Neuropsychological Factors Associated with Treatment Response and Adverse Events of Atomoxetine in Children with...
Express Scripts finds generic antidepressant users as adherent as brand-name counterparts - Drug Store News
Best Place To Buy Atomoxetine cheap * Licensed And Generic Products For Sale * Free Worldwide Shipping | Mjolnir Training
Atomoxetine Cheap Order - Target Pharmacy Atomoxetine - Atomoxetine Pills Purchase
BTC Accepted cheap Atomoxetine Safe Buy Fastest U.S. Shipping - A.P.& A. Poland
Social Network - Blog View - Atomoxetine Ligne Bon Marche Achat Visa - Atomoxetine Baisse Pr
Effects of Atomoxetine on Cognitive Function in Schizophrenia - Full Text View - ClinicalTrials.gov
Order Atomoxetine 25mg Low Price. How to Purchase Strattera Saf - Blog View - MyWorldCircle
Social Network - Blog View - Discount Atomoxetine 40mg Order Online. How Can I Buy Strattera
Acheter Strattera 18 mg :: BTC payment Is Accepted | News
Serotonin and noradrenaline reuptake inhibitors (SNRIs) for fibromyalgia syndrome
Clinical Assessment of Norepinephrine Transporter Blockade Through Biochemical and Pharmacological Profiles | Circulation
SNRI Intro - Psychotropical
What are serotonin norepinephrine reuptake inhibitors? - Alpha Medical
Mail Order 10 mg Strattera cheapest - 24/7 Customer Support - Fastest U.S. Shipping - sobrelasmanos
Plus it
Atomoxetine order without rx - Uk Atomoxetine Cheapest - 留学益友问答
FENS Forum 2004 - Abstracts
Adding SSRIs or SNRIs to Tapentadol Does Not Increase Adverse Events - MPR
duloxetine - WellSpan Health Library
Atomoxetine - Side Effects, Uses, Dosage, Overdose, Pregnancy, Alcohol | RxWiki
Order Atomoxetine Online Cheap - Jap India
Fetzima (Levomilnacipran) - Side Effects, Dosage, Interactions - Drugs - Everyday Health
Psycho-Babble Medication Thread 1095035
Psycho-Babble Medication Thread 1095035
How SNRIs Work to Treat Panic Disorder
Effect of Combined Morphine and Duloxetine on Chronic Pain - AdisInsight
Cymbalta(Duloxetine) :: Information & Dosage: 60mg, 30mg, 20mg - online-cymbalta.com
Blood thinner - Eliquis copay card
ANTI ANXIETY </span> ...
Pills pills everywhere - Southern With Problems
Reboxetine - Wikipedia
magnavolge.com
US6630165B2 - Methods for providing effective reboxetine therapy with once-a-day dosing - Google Patents
Buy Venlafaxine Online
Atomoxetine Dose Adhd | SUPER FAST U.S. DELIVERY!
Atomoxetine Dosage For Adhd. Cheap Generic Pills
Atomoxetine Fda Approval - Low-cost drugstore without prescriptions
Sun Pharma launches Drizalma Sprinkle in US - Pharmaceutical Business review
Buy Atomoxetine online without prescription. Call us!
Atomoxetine Vs Ritalin. Order CHEAP Pills Safety and Securely
Buy Generic Atomoxetine | Different payment options
Atomoxetine Generic Canada >> Free pill...
Buy Generic Atomoxetine >> Purchase Tabs...
Ohfarm Research and Development - 第362页 - innovative farm - learn, share, and help build a better world that people want to...
Buy Atomoxetine Online Uk | Safe and securely
Cyanodothiepin
... over norepinephrine and dopamine uptake) inhibitor of the reuptake of serotonin that was never marketed. It also has moderate ... affinity for the muscarinic acetylcholine receptors and weak/negligible affinity for the α1-adrenergic, 5-HT2A, D1, and D2 ... Selective serotonin reuptake inhibitors, Tricyclic antidepressants, All stub articles, Nervous system drug stubs). ... a Selective 5-Hydroxytryptamine Reuptake Inhibitor". Drug Development Research. 29 (3): 235-248. doi:10.1002/ddr.430290311. ...
Adrenergic agonist
Two uptake mechanisms exist for terminating the action of adrenergic catecholamines - uptake 1 and uptake 2. Uptake 1 occurs at ... Inhibitors of these enzymes act as indirect agonists of adrenergic receptors as they prolong the action of catecholamines at ... the adrenergic receptors). Directly acting adrenergic agonists act on adrenergic receptors. All adrenergic receptors are G- ... Indirectly acting adrenergic agonists affect the uptake and storage mechanisms involved in adrenergic signalling. ...
Xylazine
... appears to reduce sensitivity to insulin and glucose uptake in humans. Yohimbine, an α2 adrenergic receptor antagonist ... Xylazine also serves as a transport inhibitor by suppressing norepinephrine transport function through competitive inhibition ... Xylazine is a potent α2 adrenergic agonist. When xylazine and other α2 adrenergic receptor agonists are administered, they ... It is an analog of clonidine and an agonist at the α2 class of adrenergic receptor. In veterinary anesthesia, xylazine is often ...
Serotonin-norepinephrine reuptake inhibitor
Assays have shown that SNRIs have insignificant penchant for mACh, α1 and α2 adrenergic, or H1 receptors. Agents with dual ... Active transport system regulates the uptake of tryptophan across the blood-brain barrier. Serotonergic pathways are classified ... Monoamine reuptake inhibitor List of antidepressants Serotonin releasing agent Selective serotonin reuptake inhibitor (SSRI) ... Selective serotonin reuptake inhibitors (SSRIs) selectively inhibit the reuptake of serotonin and are a widely used group of ...
Serotonin-norepinephrine-dopamine reuptake inhibitor
2008). "In-vitro and in-vivo characterization of JNJ-7925476, a novel triple monoamine uptake inhibitor". European Journal of ... at functionally important adrenergic receptor sites in the brain. However, elation may be associated with an excess of such ... Wong, DT; Bymaster, FP (1978). "An inhibitor of dopamine uptake, LR5182, cis-3-(3,4-dichlorophenyl)-2-n,n-dimethylaminomethyl- ... Wong DT, Bymaster FP, Engleman EA (1995). "Prozac (fluoxetine, Lilly 110140), the first selective serotonin uptake inhibitor ...
List of MeSH codes (D27)
... adrenergic uptake inhibitors MeSH D27.505.519.625.600.220 - dopamine uptake inhibitors MeSH D27.505.519.625.600.850 - serotonin ... adrenergic uptake inhibitors MeSH D27.505.696.577.600.220 - dopamine uptake inhibitors MeSH D27.505.696.577.600.850 - serotonin ... adrenergic beta-antagonists MeSH D27.505.519.625.050.601 - adrenergic uptake inhibitors MeSH D27.505.519.625.120 - cholinergic ... adrenergic beta-antagonists MeSH D27.505.696.577.050.601 - adrenergic uptake inhibitors MeSH D27.505.696.577.120 - cholinergic ...
Diclofensine
Nakachi N, Kiuchi Y, Inagaki M, Inazu M, Yamazaki Y, Oguchi K (August 1995). "Effects of various dopamine uptake inhibitors on ... Gasić S, Korn A, Eichler HG (May 1986). "Effect of diclofensine, a novel antidepressant, on peripheral adrenergic function". ... 1982). "Diclofensine (Ro 8-4650)--a potent inhibitor of monoamine uptake: biochemical and behavioural effects in comparison ... Di Renzo G, Amoroso S, Taglialatela M, Canzoniero LM, Maida P, Lombardi G, Annunziato L (1988). "Pure uptake blockers of ...
Besipirdine
... like acetylcholinesterase inhibitors. Other treatments target the adrenergic system and have been shown to improve memory ... and inhibits norepinephrine uptake. The exact pathway is not yet understood but it has been shown that besipirdine does not ... Interest in besipirdine as a treatment for OAB was piqued by its known effects on the adrenergic system. In isolated studies, ... Besipirdine was originally suggested as a treatment for OCD due to its effects on the adrenergic and serotonergic systems. "In ...
Agomelatine
Binding studies indicate that it has no effect on monoamine uptake and no affinity for adrenergic, histamine, cholinergic, ... Inhibitors of these enzymes, e.g. the SSRI antidepressant fluvoxamine, reduce its clearance and can therefore lead to an ... blockade of which enhances the activity of frontocortical dopaminergic and adrenergic pathways". The Journal of Pharmacology ...
Nortriptyline
Schmidt AW, Hurt SD, Peroutka SJ (1989). "'[3H]quipazine' degradation products label 5-HT uptake sites". Eur. J. Pharmacol. 171 ... Bylund DB, Snyder SH (1976). "Beta adrenergic receptor binding in membrane preparations from mammalian brain". Mol. Pharmacol. ... 1996). "Interactions of selective serotonin reuptake inhibitors with the serotonin 5-HT2c receptor". Psychopharmacology. 126 (3 ... guanethidine reserpine Nortriptyline is a strong norepinephrine reuptake inhibitor and a moderate serotonin reuptake inhibitor ...
Phospholamban
When phosphorylated (by PKA) - disinhibition of Ca2+-ATPase of SR leads to faster Ca2+ uptake into the sarcoplasmic reticulum, ... Thus, activators of PKA, such as the beta-adrenergic agonist epinephrine (released by sympathetic stimulation), may enhance the ... In the unphosphorylated state, phospholamban is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca2+-ATPase (SERCA2) ...
Mepiprazole
It acts as a 5-HT2A and α1-adrenergic receptor antagonist and inhibits the reuptake and induces the release of serotonin, ... effects on uptake and retention of monoamines in rat brain synaptosomes". Psychopharmacology. 48 (3): 295-301. doi:10.1007/ ... dopamine, and norepinephrine to varying extents, and has been described as a serotonin antagonist and reuptake inhibitor (SARI ...
Agmatine
... specific-selective uptake sites, organic cation transporters (mostly OCT2 subtype), extraneuronal monoamine ... Agmatine binds to α2-adrenergic receptor and imidazoline receptor binding sites, and blocks NMDA receptors and other cation ... Agmatine is a precursor for polyamine synthesis, competitive inhibitor of polyamine transport, inducer of spermidine/spermine ... It is synthesized in the brain, stored in synaptic vesicles, accumulated by uptake, released by membrane depolarization, and ...
Cocaine intoxication
Plasminogen activator inhibitor is also increased following cocaine use, thereby promoting thrombosis. Cocaine acts like a ... Fareed, Fareed N.; Chan, Gar; Hoffman, Robert S. (2007-12-01). "Death temporally related to the use of a Beta adrenergic ... This drug binds and blocks monoamine (dopamine, epinephrine, norepinephrine, and serotonin) re-uptake transporters with equal ... Cocaine-induced platelet activation and thrombus formation is another deleterious effect, caused by alpha-adrenergic- and ...
Oxidopamine
After the uptake, oxidation of oxidopamine takes place by monoamine oxidase and hydrogen peroxide (H2O2) is generated. Hydrogen ... The real purpose of 6-hydroxydopamine is to increase sensitivity to alpha- and beta-adrenergic agonists. The supersensitivity ... Oxidopamine is often used in conjunction with a selective noradrenaline reuptake inhibitor (such as desipramine) to selectively ... It is also thought that toxic effects of 6-OHDA are caused by the uptake of the substance into the catecholaminergic nerve ...
Atomoxetine
... 's status as a serotonin transporter (SERT) inhibitor at clinical doses in humans is uncertain. A PET imaging study ... Supporting atomoxetine's selectivity, a human study found no effects on platelet serotonin uptake (a marker of SERT inhibition ... but could be potentiated by NMDA or an α1-adrenergic receptor antagonist, suggesting a glutaminergic mechanism. In Sprague ... Kasi PM, Mounzer R, Gleeson GH (2011). "Cardiovascular side effects of atomoxetine and its interactions with inhibitors of the ...
Oxaprotiline
Waldmeier PC, Baumann PA, Hauser K, Maitre L, Storni A (June 1982). "Oxaprotiline, a noradrenaline uptake inhibitor with an ... It has negligible affinity for the serotonin transporter, dopamine transporter, α2-adrenergic receptor, and muscarinic ... Dextroprotiline acts as a potent norepinephrine reuptake inhibitor and H1 receptor antagonist, as well as a very weak α1- ... Oxaprotiline (developmental code name C 49-802 BDA), also known as hydroxymaprotiline, is a norepinephrine reuptake inhibitor ...
Dopexamine
It also inhibits of neuronal re-uptake of norepinephrine (Uptake-1). These activities increase cardiac output and increase ... It is not an α-adrenergic agonist, does not cause vasoconstriction, and is not a pressor agent. As of 2004 there was some ... It should not be used in people taking monoamine oxidase inhibitors, nor in people who have certain adrenal cancers, low ... It also inhibits the neuronal re-uptake of norepinephrine. The most common adverse effects include fast heart beats and nausea ...
Amitriptyline
Another active metabolite is (E)-10-hydroxynortriptyline, which is a norepinephrine uptake inhibitor four times weaker than ... Amitriptyline additionally acts as a potent inhibitor of the serotonin 5-HT2A, 5-HT2C, the α1A-adrenergic, the histamine H1 and ... A case of clinically significant interaction with potent CYP2D6 inhibitor terbinafine has been reported. A potent inhibitor of ... Schmidt AW, Hurt SD, Peroutka SJ (1989). "'[3H]quipazine' degradation products label 5-HT uptake sites". Eur. J. Pharmacol. 171 ...
Fluacizine
It is known to act as a norepinephrine reuptake inhibitor, antihistamine, and anticholinergic. The drug was developed in the ... 190-. ISBN 978-1-4831-4673-7. Arefolov VA, Panasyuk LV, Raevskii KS, Kostyukov VI (1974). "Effect of fluacizine on the uptake ... Arefolov VA, Panasiuk LV, Firsov VK (1975). "[Neuromediator content in the synaptic vesicles of rat adrenergic nerves in some ... Arefolov VA, Panasyuk LV (1974). "Effect of fluacizine on the uptake of exogenous noradrenalin". Bull. Exp. Biol. Med. 77 (5): ...
Serotonin
Selective serotonin reuptake inhibitors (SSRI's) are a class of drugs demonstrated to be an effective treatment in major ... Some drugs inhibit the re-uptake of serotonin, making it stay in the synaptic cleft longer. The tricyclic antidepressants (TCAs ... Additionally, it inhibits the release of norepinephrine from adrenergic nerves. Serotonin is also a growth factor for some ... Popa D, Léna C, Alexandre C, Adrien J (April 2008). "Lasting syndrome of depression produced by reduction in serotonin uptake ...
Clovoxamine
A double-blind comparative study of diazepam and clovoxamine, a novel inhibitor of noradrenaline and serotonin reuptake". ... Saletu B, Grünberger J, Rajna P, Karobath M (1980). "Clovoxamine and fluvoxamine-2 biogenic amine re-uptake inhibiting ... adrenergic, and serotonin receptors. The compound is structurally related to fluvoxamine. Freeman HL, Wakelin JS, Calanca A, ... It acts as a serotonin-norepinephrine reuptake inhibitor (SNRI), with little affinity for the muscarinic acetylcholine, ...
Guanethidine
Adrenergic release inhibitors, Azocanes, Guanidines, Ophthalmology drugs). ... uptake 1), and uptake is essential for the drug's action. Once guanethidine has entered the nerve, it is concentrated in ... Guanethidine is transported by uptake 1 into the presynaptic terminal transported by norepinephrine transporter (NET). (In this ...
Ciclazindol
It acts as a norepinephrine reuptake inhibitor, and to a lesser extent as a dopamine reuptake inhibitor. Ciclazindol has no ... Oh VM, Ehsanullah RS, Leighton M, Kirby MJ (January 1979). "Influence of ciclazindol on monoamine uptake and CNS function in ... effects on the SERT, 5-HT receptors, mACh receptors, or α-adrenergic receptors, and has only weak affinity for the H1 receptor ... Norepinephrine reuptake inhibitors, Chloroarenes, All stub articles, Gastrointestinal system drug stubs, Nervous system drug ...
Hyperkalemia
Beta2-adrenergic agonists act on beta-2 receptors to drive potassium into the cells. Therefore, beta blockers can raise ... Calcineurin inhibitors such as cyclosporine, tacrolimus, diazoxide, and minoxidil can cause hyperkalemia. Box jellyfish venom ... Insulin deficiency can cause hyperkalemia as the hormone insulin increases the uptake of potassium into the cells. ... Hwa Lee, Chang; Ho Kim, Gheun (31 December 2007). "Electrolyte and Acid-Base Disturbances Induced by Clacineurin Inhibitors". ...
Guanadrel
... is a postganglionic adrenergic blocking agent. Uptake of guanadrel and storage in sympathetic neurons occurs via the ... Adrenergic release inhibitors, Antihypertensive agents, Guanidines, Ketals, Spiro compounds). ...
Chlorprothixene
... has also been found to act as FIASMA (functional inhibitor of acid sphingomyelinase). One metabolite of ... Bylund DB, Snyder SH (1976). "Beta adrenergic receptor binding in membrane preparations from mammalian brain". Mol. Pharmacol. ... Haunsø A, Buchanan D (2007). "Pharmacological characterization of a fluorescent uptake assay for the noradrenaline transporter ... the amelioration of anxiety and agitation due to use of selective serotonin reuptake inhibitors for depression and, off-label, ...
Neuromodulation
Monoamine oxidase inhibitors allow reuptake of biogenic amine neurotransmitters from the synapse, but inhibit an enzyme which ... Noradrenaline is released from the neurons, and acts on adrenergic receptors. Noradrenaline is often released steadily so that ... regulation of glutamate uptake by astrocytes and LTD, and consolidation of memory. The dopamine or dopaminergic system consists ... Selective serotonin reuptake inhibitors (SSRIs) such as fluoxetine are widely used antidepressants that specifically block the ...
Central nervous system fatigue
This may be due to a counter-acting mechanism: BCAAs also limit the uptake of tyrosine, another aromatic amino acid, like ... This may be explained by a paradoxical decrease in adrenergic activity led by feedback mechanisms. In the brain, serotonin is a ... In 2008, Roelands and colleagues53 studied the effect of reboxetine, a pure NE reuptake inhibitor, similar to atomoxetine, in 9 ... Further supporting this theory is the fact that dopamine reuptake inhibitors as well as norepinephrine dopamine reuptake ...
Methamphetamine
... is also an agonist of the alpha-2 adrenergic receptors and sigma receptors with a greater affinity for σ1 than ... Owing to the effect pH has on absorption, proton pump inhibitors, which reduce gastric acid, are known to interact with ... which prevents monoamine uptake into the vesicles and promotes their release. This results in the outflow of monoamines from ... Methamphetamine is metabolized by the liver enzyme CYP2D6, so CYP2D6 inhibitors will prolong the elimination half-life of ...
Pheochromocytoma
... monoamine oxidase inhibitors, serotonin norepinephrine reuptake inhibitors (SNRI), and methyldopa.[non-primary source needed] ... Adrenergic (Epinephrine and metanephrine) More likely to indicate an adrenal tumor[non-primary source needed] When plasma ... MIBG was well-suited for uptake by most neuroendocrine tumors. Furthermore, if a patient was found to be positive on an MIBG ... Monoamine Oxidase Inhibitors, Clonidine Withdrawal Including but not limited to cocaine use Misuse of over-the-counter ...
Glaucoma
Echothiophate, an acetylcholinesterase inhibitor, is used in chronic glaucoma. Carbonic anhydrase inhibitors, such as ... Alpha2-adrenergic agonists, such as brimonidine and apraclonidine, work by a dual mechanism, decreasing aqueous humor ... correlating disease distribution with service provision and uptake in a population in Northern England, UK". Eye. 24 (9): 1478- ... Rho kinase inhibitors, such as ripasudil, work by inhibition of the actin cytoskeleton, resulting in the morphological changes ...
Norepinephrine transporter
... norepinephrine-dopamine reuptake inhibitors (NDRIs), norepinephrine reuptake inhibitors (NRIs or NERIs) and the tricyclic ... Morón JA, Brockington A, Wise RA, Rocha BA, Hope BT (January 2002). "Dopamine uptake through the norepinephrine transporter in ... This suggests that in schizophrenia, the alpha-2 adrenergic receptor, a presynaptic inhibitory receptor, may be less sensitive ... A study reported that the NET inhibitor reboxetine reduced the stimulant effects of MDMA in humans, demonstrating the crucial ...
Cystic fibrosis transmembrane conductance regulator
Other members of the ABC transporter superfamily are involved in the uptake of nutrients in prokaryotes, or in the export of a ... Thiagarajah JR, Verkman AS (September 2012). "CFTR inhibitors for treating diarrheal disease". Clinical Pharmacology and ... "A C-terminal motif found in the beta2-adrenergic receptor, P2Y1 receptor and cystic fibrosis transmembrane conductance ... it also simultaneously inhibits the uptake of sodium ions by another channel protein. Both of these functions help to maintain ...
Methylenedioxypyrovalerone
... a promising class of monoamine uptake inhibitors". Journal of Medicinal Chemistry. 49 (4): 1420-32. doi:10.1021/jm050797a. PMC ... that the use of beta blockers to treat hypertension in these patients can cause an unopposed peripheral alpha-adrenergic effect ... is a stimulant of the cathinone class that acts as a norepinephrine-dopamine reuptake inhibitor (NDRI). It was first developed ... Norepinephrine-dopamine reuptake inhibitors, Pyrrolidinophenones, Euphoriants, Stimulants, Designer drugs). ...
Lamotrigine
"Lamotrigine inhibits monoamine uptake in vitro and modulates 5-hydroxytryptamine uptake in rats". European Journal of ... It is known that lamotrigine is a weak inhibitor of human dihydrofolate reductase (DHFR) and other, more powerful, human DHFR ... adrenergic, dopamine D1 and D2, muscarinic, GABA, histaminergic H1, serotonin 5-HT2, and N-methyl-D-aspartate). Inhibitory ... Lamotrigine is a weak inhibitor of dihydrofolate reductase, but whether this effect is sufficient to contribute to a mechanism ...
Iprindole
... is unique compared to most other TCAs in that it is a very weak and negligible inhibitor of the reuptake of serotonin ... Horn AS, Trace RC (July 1974). "Structure-activity relations for the inhibition of 5-hydroxytryptamine uptake by tricyclic ... Bylund DB, Snyder SH (1976). "Beta adrenergic receptor binding in membrane preparations from mammalian brain". Mol. Pharmacol. ... It is presumed to act as an inhibitor or antagonist/inverse agonist of all sites. Considering the range of its therapeutic ...
Butriptyline
... moderate 5-HT2 and α1-adrenergic receptor antagonist, and very weak or negligible monoamine reuptake inhibitor. These actions ... Richelson E, Pfenning M (September 1984). "Blockade by antidepressants and related compounds of biogenic amine uptake into rat ... The drug has relatively weak effects as an alpha-1 blocker and has no effects as a norepinephrine reuptake inhibitor, so is ... Randrup A, Braestrup C (August 1977). "Uptake inhibition of biogenic amines by newer antidepressant drugs: relevance to the ...
Biochemical cascade
In the absence of mitogenic signals, cyclin-CDKs and the G1-S transition are suppressed by cell cycle inhibitors including Ink4 ... mitochondrial dysfunction and impaired glucose uptake in vulnerable neuronal populations. Studies of animal and cell culture ... Signaling Pathway The Sonic hedgehog Signaling Pathway The Wnt signaling pathway The JAK-STAT signaling pathway The Adrenergic ... Cruciat, CM.; Niehrs, C. (19 October 2012). "Secreted and Transmembrane Wnt Inhibitors and Activators". Cold Spring Harbor ...
Adrenergic receptor
2012-09-21). "Paroxetine is a direct inhibitor of g protein-coupled receptor kinase 2 and increases myocardial contractility". ... lipolysis in adipose tissue anabolism in skeletal muscle uptake of potassium into cells relax non-pregnant uterus relax ... Beta adrenergic receptor kinase Beta adrenergic receptor kinase-2 There is no α1C receptor. There was a subtype known as C, but ... The adrenergic receptors or adrenoceptors are a class of G protein-coupled receptors that are targets of many catecholamines ...
Trimipramine
... α1-adrenergic Moderate: D2, mACh Weak: 5-HT2C, D1, α2-adrenergic In spite of its atypical nature and different profile of ... monoamine oxidase inhibitors (MAOIs) (e.g., phenelzine, isocarboxazid), and selective serotonin reuptake inhibitors (e.g., ... Randrup A, Braestrup C (1977). "Uptake inhibition of biogenic amines by newer antidepressant drugs: relevance to the dopamine ... That said, blockade of the 5-HT2A, 5-HT2C, and α2-adrenergic receptors, as with mirtazapine, has also been implicated in ...
Modafinil
September 2012). "R-modafinil (armodafinil): a unique dopamine uptake inhibitor and potential medication for psychostimulant ... Warot D, Corruble E, Payan C, Weil JS, Puech AJ (1993). "Subjective effects of modafinil, a new central adrenergic stimulant in ... a dopamine re-uptake inhibitor) do not reduce cocaine self-administration. Modafinil is available in the form of 100 and 200 mg ... "Modafinil and its structural analogs as atypical dopamine uptake inhibitors and potential medications for psychostimulant use ...
Neurotransmitter
Fluoxetine is a selective serotonin re-uptake inhibitor (SSRI), which blocks re-uptake of serotonin by the presynaptic cell ... LC firing may also increase anxiety ...Stimulation of β-adrenergic receptors in the amygdala results in enhanced memory for ... This can be accomplished by blocking re-uptake or inhibiting degradative enzymes. Lastly, drugs can also prevent an action ... Cocaine, for example, blocks the re-uptake of dopamine back into the presynaptic neuron, leaving the neurotransmitter molecules ...
Adult attention deficit hyperactivity disorder
The uptake transporters for dopamine and norepinephrine are overly active and clear these neurotransmitters from the synapse a ... Viloxazine is a selective norepinephrine reuptake inhibitor that was FDA-approved to treat ADHD in children, adolescents, and ... psychological interventions have identified alterations in the dopaminergic and adrenergic pathways of individuals with ADHD. ... reversal of uptake transporters and reversible MAO inhibition. Thus amphetamines actively increases the release of these ...
Selective serotonin reuptake inhibitor
Weinrieb RM, Auriacombe M, Lynch KG, Lewis JD (March 2005). "Selective serotonin re-uptake inhibitors and the risk of bleeding ... While trazodone (an antidepressant with alpha adrenergic receptor blockade) is a notorious cause of priapism, cases of priapism ... Selective serotonin reuptake inhibitors (SSRIs) are a class of drugs that are typically used as antidepressants in the ... Taking monoamine oxidase inhibitors (MAOIs) in combination with SSRIs can be fatal, since MAOIs disrupt monoamine oxidase, an ...
Octreotide
ISBN 978-3-7741-9846-3. Hovind P, Simonsen L, Bülow J (March 2010). "Decreased leg glucose uptake during exercise contributes ... Attempts at caloric restriction or pharmacotherapy with adrenergic or serotonergic agents have previously met with little or ... though it is a more potent inhibitor of growth hormone, glucagon, and insulin than the natural hormone. It was first ...
Perilipin-1
"Entrez Gene: PLIN perilipin". Mobilization and Cellular Uptake of Stored Fats (with Animation) Brasaemle DL, Subramanian V, ... In times of energy deficit, Perilipin is hyperphosphorylated by PKA following β-adrenergic receptor activation. Phosphorylated ... "In silico discovery of a perilipin 1 inhibitor to be used as a new treatment for obesity". European Review for Medical and ...
Para-Methoxyamphetamine
Many amphetamines and adrenergic compounds raise body temperatures, whereas some tend to produce more euphoric activity or ... Green AL, El Hait MA (April 1980). "p-Methoxyamphetamine, a potent reversible inhibitor of type-A monoamine oxidase in vitro ... Tseng LF, Menon MK, Loh HH (May 1976). "Comparative actions of monomethoxyamphetamines on the release and uptake of biogenic ... reversible inhibitor of the enzyme MAO-A with no significant effects on MAO-B, and the combination of this property and ...
Red blood cell
6-1 Uptake and Delivery of the Respiratory Gasses". In Brobeck, John R., PhD, M.D. (ed.). Best & Taylor's Physiological basis ... Inhibitors of eryptosis include erythropoietin, nitric oxide, catecholamines and high concentrations of urea. Much of the ... and β-adrenergic receptors. Lipid rafts that have been implicated in cell signaling events in nonerythroid cells have been ... Iron Transport and Cellular Uptake by Kenneth R. Bridges, Information Center for Sickle Cell and Thalassemic Disorders. ...
Anxiolytic
Selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs) are new generations of ... SSRIs increase the serotonin level in the brain by inhibiting serotonin uptake pumps on serotonergic systems, without ... SNRIs can target serotonin and norepinephrine transporters while imposing insignificant effect on other adrenergic (α1, α2, and ... Antidepressants including selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs ...
Browsing Journal Articles by Subject "Adrenergic Uptake Inhibitors"
Browsing Journal Articles by Subject
d-MDMA during vitamin E deficiency: effects on dopaminergic neurotoxicity and hepatotoxicity
Four-week Study of the Safety and Efficacy of NLS-2 (Mazindol Extended Release) in the Treatment of Narcolepsy - Full Text View...
Current version of study NCT03527316 on ClinicalTrials.gov
Reserpine
Alpha adrenergic uptake inhibitor. *Depletes CNS and peripheral Catecholamine stores (Norepinephrine, Serotonin, Dopamine). * ... ACE Inhibitor ACE Inhibitor in CHF Acetazolamide Adenosine Alpha Adrenergic Antagonist Amiodarone Amiodarone Pulmonary Toxicity ... An alkaloid, derived from the roots of Rauwolfia serpentine and vomitoria, and an adrenergic uptake inhibitor with ... Presynaptic Adrenergic Release Inhibitor Hypertension in Diabetes Mellitus Rhinitis Medicamentosa Toxin Induced Vital Sign ...
2020 Binge Eating Disorder Drug Pipeline Report- Current Status, Phase, Mechanism, Route of Administration, and Companies, of...
Diverse types of targeted therapies are being explored through clinical trials including Adrenergic uptake inhibitors; Aldehyde ... PDE7 inhibitor; Trace Amine-Associated Receptor 1 (TAAR1) Agonists; Dopamine uptake inhibitors; Serotonin uptake inhibitors. ... dehydrogenase 2 (ALDH2) inhibitors; Glucagon-like peptide 1 (GLP-1) receptor agonist; Orexin-1 Antagonist; ...
electronic library - Norepinephrine transporter inhibition alters the hemodynamic response to hypergravity
MESH TREE NUMBER CHANGES - 2015 MeSH
A11.671.501.75 Adrenergic Neurons A8.663.100 A8.675.100 Adrenergic Uptake Inhibitors D27.505.519.562.437.50 Adsorption G2.149. ... A8.675.703.550 Neurotransmitter Uptake Inhibitors D27.505.519.562.437 Nissl Bodies A8.663.712 A8.675.712 Nitrergic Neurons ... A8.675.895 Serotonin Uptake Inhibitors D27.505.519.562.437.850 Siblings I1.880.225.500.505 I1.880.853.150.500.505 Sigmoidoscopy ... A8.186.211.730.885.287.500.345.600 GABA Uptake Inhibitors D27.505.519.562.437.535 GABAergic Neurons A8.663.289 A8.675.289 ...
H₂-receptor antagonist
Beta2-adrenergic receptor agonist) - adrenergic antagonist (Alpha blocker, Beta blocker) - Adrenergic uptake inhibitor. ... Serotonin receptor agonist - Serotonin antagonist (5-HT3 antagonist) - Serotonin uptake inhibitor (SSRI). ... Adrenergic receptor. adrenergic agonist (Adrenergic alpha-agonist, ... Proton pump inhibitors. Esomeprazole, Lansoprazole, Omeprazole, Pantoprazole, Rabeprazole, Tenatoprazole. Other. Carbenoxolone ...
DeCS
Inhibitors, Adrenergic Reuptake Inhibitors, Adrenergic Uptake Reuptake Inhibitors, Adrenergic Uptake Inhibitors, Adrenergic ... Inhibitors, Adrenergic Reuptake. Inhibitors, Adrenergic Uptake. Reuptake Inhibitors, Adrenergic. Uptake Inhibitors, Adrenergic ... Adrenergic Uptake Inhibitors Entry term(s). Adrenergic Reuptake Inhibitors ... Adrenergic Uptake Inhibitors - Preferred Concept UI. M0028095. Scope note. Drugs that block the transport of adrenergic ...
Code System Concept
DeCS
Adrenergic Uptake Inhibitors [D27.505.519.562.437.050] Adrenergic Uptake Inhibitors * Dopamine Uptake Inhibitors [D27.505. ... Inhibitor, Serotonin Uptake Inhibitors, 5 HT Uptake Inhibitors, 5 Hydroxytryptamine Uptake Inhibitors, 5-HT Uptake Inhibitors, ... Uptake Inhibitor, 5-HT Uptake Inhibitor, 5-Hydroxytryptamine Uptake Inhibitor, Serotonin Uptake Inhibitors, 5 HT Uptake ... Uptake Inhibitor, 5-HT. Uptake Inhibitor, 5-Hydroxytryptamine. Uptake Inhibitor, Serotonin. Uptake Inhibitors, 5 HT. Uptake ...
IMSEAR at SEARO: Search
mazindol
Adrenergic Uptake Inhibitors. MeSH PA. D002491. Central Nervous System Agents. MeSH PA. D000697. Central Nervous System ... Neurotransmitter Uptake Inhibitors. Drug Use , Suggest Off label Use Form, ,View source of the data, Disease. Relation. SNOMED_ ... It inhibits uptake of catecholamines and blocks the binding of cocaine to the dopamine uptake transporter. *Molecular weight: ...
Atomoxetine Hydrochloride | Colorado PROFILES
Parkinson Disease Treatment & Management: Approach Considerations, Symptomatic Therapy, Early Disease, Symptomatic Therapy,...
... a predominantly noradrenergic reuptake inhibitor TCA), venlafaxine (a serotonin-noradrenaline uptake inhibitor), citalopram (an ... with serotoninergic and adrenergic activity), desipramine ( ... MAO-B inhibitors. MAO-B inhibitors, such as selegiline and ... These characteristics make MAO-B inhibitors a good choice as initial treatment for many patients. When the MAO-B inhibitor ... Adding a dopamine agonist, catechol-O -methyltransferase (COMT) inhibitor, monoamine oxidase (MAO)-B inhibitor, or selective ...
Parkinson Disease Treatment & Management: Approach Considerations, Symptomatic Therapy, Early Disease, Symptomatic Therapy,...
... a predominantly noradrenergic reuptake inhibitor TCA), venlafaxine (a serotonin-noradrenaline uptake inhibitor), citalopram (an ... with serotoninergic and adrenergic activity), desipramine ( ... MAO-B inhibitors. MAO-B inhibitors, such as selegiline and ... These characteristics make MAO-B inhibitors a good choice as initial treatment for many patients. When the MAO-B inhibitor ... Adding a dopamine agonist, catechol-O -methyltransferase (COMT) inhibitor, monoamine oxidase (MAO)-B inhibitor, or selective ...
Publications | Cervo Brain Research Centre
7 Causes of Night Sweats and Hot Flashes | Rose Wellness
OPUS 4 | Untersuchung zur verkehrsmedizinischen Relevanz der Antidepressiva der neueren Generation : Auswertung der aktuellen...
... selective serotonin noradrenaline re-uptake inhibitors) NASSAs (nor-adrenergic and specific serotonergic antidepressants ). The ... selective serotonin re-uptake inhibitors) SNARIs ( selective noradrenaline re-uptake inhibitors) SNRIs ( ... selective serotonin re-uptake inhibitors) SNARIs ( selective noradrenaline re-uptake inhibitors) SNRIs ( selective serotonin ... noradrenaline re-uptake inhibitors) NASSAs (nor-adrenergic and specific serotonergic antidepressants ). The individual drugs in ...
Protriptyline: Uses, Interactions, Mechanism of Action | DrugBank Online
Adrenergic Uptake Inhibitors. *Agents that produce hypertension. *Agents that reduce seizure threshold ... TCAs are potent inhibitors of serotonin and norepinephrine reuptake. In addition, TCAs down-regulate cerebral cortical β- ... TCAs also block histamine H1 receptors, alpha1-adrenergic receptors and muscarinic receptors, which accounts for their sedative ... Kovachich GB, Aronson CE, Brunswick DJ: Effect of repeated administration of antidepressants on serotonin uptake sites in ...
Ashley MacLean | Profiles RNS
Another reminder that there is no autism epidemic - RESPECTFUL INSOLENCE
MESH TREE NUMBER CHANGES - 2015 MeSH
A11.671.501.75 Adrenergic Neurons A8.663.100 A8.675.100 Adrenergic Uptake Inhibitors D27.505.519.562.437.50 Adsorption G2.149. ... A8.675.703.550 Neurotransmitter Uptake Inhibitors D27.505.519.562.437 Nissl Bodies A8.663.712 A8.675.712 Nitrergic Neurons ... A8.675.895 Serotonin Uptake Inhibitors D27.505.519.562.437.850 Siblings I1.880.225.500.505 I1.880.853.150.500.505 Sigmoidoscopy ... A8.186.211.730.885.287.500.345.600 GABA Uptake Inhibitors D27.505.519.562.437.535 GABAergic Neurons A8.663.289 A8.675.289 ...
MESH TREE NUMBER CHANGES - 2015 MeSH
A11.671.501.75 Adrenergic Neurons A8.663.100 A8.675.100 Adrenergic Uptake Inhibitors D27.505.519.562.437.50 Adsorption G2.149. ... A8.675.703.550 Neurotransmitter Uptake Inhibitors D27.505.519.562.437 Nissl Bodies A8.663.712 A8.675.712 Nitrergic Neurons ... A8.675.895 Serotonin Uptake Inhibitors D27.505.519.562.437.850 Siblings I1.880.225.500.505 I1.880.853.150.500.505 Sigmoidoscopy ... A8.186.211.730.885.287.500.345.600 GABA Uptake Inhibitors D27.505.519.562.437.535 GABAergic Neurons A8.663.289 A8.675.289 ...
MESH TREE NUMBER CHANGES - 2015 MeSH
A11.671.501.75 Adrenergic Neurons A8.663.100 A8.675.100 Adrenergic Uptake Inhibitors D27.505.519.562.437.50 Adsorption G2.149. ... A8.675.703.550 Neurotransmitter Uptake Inhibitors D27.505.519.562.437 Nissl Bodies A8.663.712 A8.675.712 Nitrergic Neurons ... A8.675.895 Serotonin Uptake Inhibitors D27.505.519.562.437.850 Siblings I1.880.225.500.505 I1.880.853.150.500.505 Sigmoidoscopy ... A8.186.211.730.885.287.500.345.600 GABA Uptake Inhibitors D27.505.519.562.437.535 GABAergic Neurons A8.663.289 A8.675.289 ...
MESH TREE NUMBER CHANGES - 2015 MeSH
A11.671.501.75 Adrenergic Neurons A8.663.100 A8.675.100 Adrenergic Uptake Inhibitors D27.505.519.562.437.50 Adsorption G2.149. ... A8.675.703.550 Neurotransmitter Uptake Inhibitors D27.505.519.562.437 Nissl Bodies A8.663.712 A8.675.712 Nitrergic Neurons ... A8.675.895 Serotonin Uptake Inhibitors D27.505.519.562.437.850 Siblings I1.880.225.500.505 I1.880.853.150.500.505 Sigmoidoscopy ... A8.186.211.730.885.287.500.345.600 GABA Uptake Inhibitors D27.505.519.562.437.535 GABAergic Neurons A8.663.289 A8.675.289 ...
MESH TREE NUMBER CHANGES - 2015 MeSH
A11.671.501.75 Adrenergic Neurons A8.663.100 A8.675.100 Adrenergic Uptake Inhibitors D27.505.519.562.437.50 Adsorption G2.149. ... A8.675.703.550 Neurotransmitter Uptake Inhibitors D27.505.519.562.437 Nissl Bodies A8.663.712 A8.675.712 Nitrergic Neurons ... A8.675.895 Serotonin Uptake Inhibitors D27.505.519.562.437.850 Siblings I1.880.225.500.505 I1.880.853.150.500.505 Sigmoidoscopy ... A8.186.211.730.885.287.500.345.600 GABA Uptake Inhibitors D27.505.519.562.437.535 GABAergic Neurons A8.663.289 A8.675.289 ...
MESH TREE NUMBER CHANGES - 2015 MeSH
A11.671.501.75 Adrenergic Neurons A8.663.100 A8.675.100 Adrenergic Uptake Inhibitors D27.505.519.562.437.50 Adsorption G2.149. ... A8.675.703.550 Neurotransmitter Uptake Inhibitors D27.505.519.562.437 Nissl Bodies A8.663.712 A8.675.712 Nitrergic Neurons ... A8.675.895 Serotonin Uptake Inhibitors D27.505.519.562.437.850 Siblings I1.880.225.500.505 I1.880.853.150.500.505 Sigmoidoscopy ... A8.186.211.730.885.287.500.345.600 GABA Uptake Inhibitors D27.505.519.562.437.535 GABAergic Neurons A8.663.289 A8.675.289 ...