Wakefulness-Promoting Agents: A specific category of drugs that prevent sleepiness by specifically targeting sleep-mechanisms in the brain. They are used to treat DISORDERS OF EXCESSIVE SOMNOLENCE such as NARCOLEPSY. Note that this drug category does not include broadly-acting central nervous system stimulants such as AMPHETAMINES.Receptors, Adrenergic, alpha-2: A subclass of alpha-adrenergic receptors found on both presynaptic and postsynaptic membranes where they signal through Gi-Go G-PROTEINS. While postsynaptic alpha-2 receptors play a traditional role in mediating the effects of ADRENERGIC AGONISTS, the subset of alpha-2 receptors found on presynaptic membranes signal the feedback inhibition of NEUROTRANSMITTER release.Receptors, Adrenergic, beta-2: A subclass of beta-adrenergic receptors (RECEPTORS, ADRENERGIC, BETA). The adrenergic beta-2 receptors are more sensitive to EPINEPHRINE than to NOREPINEPHRINE and have a high affinity for the agonist TERBUTALINE. They are widespread, with clinically important roles in SKELETAL MUSCLE; LIVER; and vascular, bronchial, gastrointestinal, and genitourinary SMOOTH MUSCLE.Receptors, Adrenergic: Cell-surface proteins that bind epinephrine and/or norepinephrine with high affinity and trigger intracellular changes. The two major classes of adrenergic receptors, alpha and beta, were originally discriminated based on their cellular actions but now are distinguished by their relative affinity for characteristic synthetic ligands. Adrenergic receptors may also be classified according to the subtypes of G-proteins with which they bind; this scheme does not respect the alpha-beta distinction.Receptors, Adrenergic, alpha: One of the two major pharmacological subdivisions of adrenergic receptors that were originally defined by the relative potencies of various adrenergic compounds. The alpha receptors were initially described as excitatory receptors that post-junctionally stimulate SMOOTH MUSCLE contraction. However, further analysis has revealed a more complex picture involving several alpha receptor subtypes and their involvement in feedback regulation.Receptors, Adrenergic, beta-1: A subclass of beta-adrenergic receptors (RECEPTORS, ADRENERGIC, BETA). The adrenergic beta-1 receptors are equally sensitive to EPINEPHRINE and NOREPINEPHRINE and bind the agonist DOBUTAMINE and the antagonist METOPROLOL with high affinity. They are found in the HEART, juxtaglomerular cells, and in the central and peripheral nervous systems.Receptors, Adrenergic, alpha-1: A subclass of alpha-adrenergic receptors that mediate contraction of SMOOTH MUSCLE in a variety of tissues such as ARTERIOLES; VEINS; and the UTERUS. They are usually found on postsynaptic membranes and signal through GQ-G11 G-PROTEINS.Receptors, Adrenergic, beta: One of two major pharmacologically defined classes of adrenergic receptors. The beta adrenergic receptors play an important role in regulating CARDIAC MUSCLE contraction, SMOOTH MUSCLE relaxation, and GLYCOGENOLYSIS.Receptors, Adrenergic, beta-3: A subclass of beta-adrenergic receptors (RECEPTORS, ADRENERGIC, BETA). The beta-3 adrenergic receptors are the predominant beta-adrenergic receptor type expressed in white and brown ADIPOCYTES and are involved in modulating ENERGY METABOLISM and THERMOGENESIS.Adrenergic alpha-Agonists: Drugs that selectively bind to and activate alpha adrenergic receptors.Prazosin: A selective adrenergic alpha-1 antagonist used in the treatment of HEART FAILURE; HYPERTENSION; PHEOCHROMOCYTOMA; RAYNAUD DISEASE; PROSTATIC HYPERTROPHY; and URINARY RETENTION.Adrenergic beta-2 Receptor Antagonists: Drugs that bind to and block the activation of ADRENERGIC BETA-2 RECEPTORS.Adrenergic beta-2 Receptor Agonists: Compounds bind to and activate ADRENERGIC BETA-2 RECEPTORS.Adrenergic alpha-Antagonists: Drugs that bind to but do not activate alpha-adrenergic receptors thereby blocking the actions of endogenous or exogenous adrenergic agonists. Adrenergic alpha-antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma.Adrenergic alpha-1 Receptor Antagonists: Drugs that bind to and block the activation of ADRENERGIC ALPHA-1 RECEPTORS.Adrenergic beta-Agonists: Drugs that selectively bind to and activate beta-adrenergic receptors.Yohimbine: A plant alkaloid with alpha-2-adrenergic blocking activity. Yohimbine has been used as a mydriatic and in the treatment of ERECTILE DYSFUNCTION.Adrenergic Antagonists: Drugs that bind to but do not activate ADRENERGIC RECEPTORS. Adrenergic antagonists block the actions of the endogenous adrenergic transmitters EPINEPHRINE and NOREPINEPHRINE.Isoproterenol: Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on the heart, bronchi, skeletal muscle, alimentary tract, etc. It is used mainly as bronchodilator and heart stimulant.Adrenergic Agonists: Drugs that bind to and activate adrenergic receptors.Propanolamines: AMINO ALCOHOLS containing the propanolamine (NH2CH2CHOHCH2) group and its derivatives.Adrenergic beta-3 Receptor Agonists: Compounds that bind to and activate ADRENERGIC BETA-3 RECEPTORS.Adrenergic alpha-2 Receptor Agonists: Compounds that bind to and activate ADRENERGIC ALPHA-2 RECEPTORS.Norepinephrine: Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic.Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.Adrenergic beta-1 Receptor Agonists: Compounds that bind to and activate ADRENERGIC BETA-1 RECEPTORS.Adrenergic alpha-1 Receptor Agonists: Compounds that bind to and activate ADRENERGIC ALPHA-1 RECEPTORS.Iodocyanopindolol: A highly selective and specific beta antagonist that is used to characterize beta-adrenoceptors.Dihydroalprenolol: Hydrogenated alprenolol derivative where the extra hydrogens are often tritiated. This radiolabeled form of ALPRENOLOL, a beta-adrenergic blocker, is used to label the beta-adrenergic receptor for isolation and study.Epinephrine: The active sympathomimetic hormone from the ADRENAL MEDULLA. It stimulates both the alpha- and beta- adrenergic systems, causes systemic VASOCONSTRICTION and gastrointestinal relaxation, stimulates the HEART, and dilates BRONCHI and cerebral vessels. It is used in ASTHMA and CARDIAC FAILURE and to delay absorption of local ANESTHETICS.Adrenergic alpha-2 Receptor Antagonists: Drugs that bind to and block the activation of ADRENERGIC ALPHA-2 RECEPTORS.Idazoxan: A benzodioxane-linked imidazole that has alpha-2 adrenoceptor antagonist activity.Adrenergic beta-1 Receptor Antagonists: Drugs that bind to and block the activation of ADRENERGIC BETA-1 RECEPTORS.alpha 1-Antitrypsin: Plasma glycoprotein member of the serpin superfamily which inhibits TRYPSIN; NEUTROPHIL ELASTASE; and other PROTEOLYTIC ENZYMES.Adrenergic beta-Antagonists: Drugs that bind to but do not activate beta-adrenergic receptors thereby blocking the actions of beta-adrenergic agonists. Adrenergic beta-antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches, and anxiety.Pindolol: A moderately lipophilic beta blocker (ADRENERGIC BETA-ANTAGONISTS). It is non-cardioselective and has intrinsic sympathomimetic actions, but little membrane-stabilizing activity. (From Martindale, The Extra Pharmocopoeia, 30th ed, p638)Radioligand Assay: Quantitative determination of receptor (binding) proteins in body fluids or tissue using radioactively labeled binding reagents (e.g., antibodies, intracellular receptors, plasma binders).Dioxanes: 1,4-Diethylene dioxides. Industrial solvents. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), dioxane itself may "reasonably be anticipated to be a carcinogen." (Merck Index, 11th ed)Arrestins: Regulatory proteins that down-regulate phosphorylated G-protein membrane receptors, including rod and cone photoreceptors and adrenergic receptors.Phenylephrine: An alpha-1 adrenergic agonist used as a mydriatic, nasal decongestant, and cardiotonic agent.Adenylate Cyclase: An enzyme of the lyase class that catalyzes the formation of CYCLIC AMP and pyrophosphate from ATP. EC 22.214.171.124.GTP-Binding Proteins: Regulatory proteins that act as molecular switches. They control a wide range of biological processes including: receptor signaling, intracellular signal transduction pathways, and protein synthesis. Their activity is regulated by factors that control their ability to bind to and hydrolyze GTP to GDP. EC 3.6.1.-.Cyclic AMP: An adenine nucleotide containing one phosphate group which is esterified to both the 3'- and 5'-positions of the sugar moiety. It is a second messenger and a key intracellular regulator, functioning as a mediator of activity for a number of hormones, including epinephrine, glucagon, and ACTH.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Signal Transduction: The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.Propranolol: A widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; ANGINA PECTORIS; HYPERTENSION; HYPERTHYROIDISM; MIGRAINE; PHEOCHROMOCYTOMA; and ANXIETY but adverse effects instigate replacement by newer drugs.Cricetinae: A subfamily in the family MURIDAE, comprising the hamsters. Four of the more common genera are Cricetus, CRICETULUS; MESOCRICETUS; and PHODOPUS.Hypoxia-Inducible Factor 1, alpha Subunit: Hypoxia-inducible factor 1, alpha subunit is a basic helix-loop-helix transcription factor that is regulated by OXYGEN availability and is targeted for degradation by VHL TUMOR SUPPRESSOR PROTEIN.Butoxamine: A beta-2 selective adrenergic antagonist. It is used primarily in animal and tissue experiments to characterize BETA-2 ANDRENERGIC RECEPTORS.Adrenergic beta-3 Receptor Antagonists: Drugs that bind to and block the activation of ADRENERGIC BETA-3 RECEPTORS.beta-Adrenergic Receptor Kinases: G-protein-coupled receptor kinases that mediate agonist-dependent PHOSPHORYLATION and desensitization of BETA-ADRENERGIC RECEPTORS.GTP-Binding Protein alpha Subunits, Gs: A family of heterotrimeric GTP-binding protein alpha subunits that activate ADENYLYL CYCLASES.Clenbuterol: A substituted phenylaminoethanol that has beta-2 adrenomimetic properties at very low doses. It is used as a bronchodilator in asthma.Cyclic AMP-Dependent Protein Kinases: A group of enzymes that are dependent on CYCLIC AMP and catalyze the phosphorylation of SERINE or THREONINE residues on proteins. Included under this category are two cyclic-AMP-dependent protein kinase subtypes, each of which is defined by its subunit composition.Transfection: The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.Dose-Response Relationship, Drug: The relationship between the dose of an administered drug and the response of the organism to the drug.Kinetics: The rate dynamics in chemical or physical systems.Protein Binding: The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.Binding, Competitive: The interaction of two or more substrates or ligands with the same binding site. The displacement of one by the other is used in quantitative and selective affinity measurements.QuinoxalinesBase Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Adrenergic Agents: Drugs that act on adrenergic receptors or affect the life cycle of adrenergic transmitters. Included here are adrenergic agonists and antagonists and agents that affect the synthesis, storage, uptake, metabolism, or release of adrenergic transmitters.Cell Line: Established cell cultures that have the potential to propagate indefinitely.Alprenolol: One of the ADRENERGIC BETA-ANTAGONISTS used as an antihypertensive, anti-anginal, and anti-arrhythmic agent.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Oxymetazoline: A direct acting sympathomimetic used as a vasoconstrictor to relieve nasal congestion. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1251)Rats, Sprague-Dawley: A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
Alpha-2 adrenergic receptor agonistsEdit. Central alpha agonists lower blood pressure by stimulating alpha-receptors in the ... an alpha-adrenergic receptor blocker, had a higher incidence of heart failure events, and the doxazosin arm of the study was ... These alpha 2 receptors are known as autoreceptors which provide a negative feedback in neurotransmission (in this case, the ... Endothelium receptor blockersEdit. Bosentan belongs to a new class of drug and works by blocking the receptors of the hormone ...
Postural orthostatic tachycardia syndrome
Antibodies against the Alpha 1 adrenergic receptor and muscarinic acetylcholine M4 receptor. ... Alpha-1 adrenergic receptor agonist Constrict the peripheral blood vessels aiding venous return. Midodrine ... alpha-2 adrenergic receptor agonist Decreases blood pressure and sympathetic nerve traffic. Clonidine, Methyldopa ... elevated levels of autoantibodies against the adrenergic alpha 1 receptor and against the muscarinic acetylcholine M4 receptor. ...
Norepinephrine works by binding and activating alpha adrenergic receptors. Norepinephrine was discovered in 1946 and was ... Norepinephrine acts on beta-1 adrenergic receptors, causing increase in heart rate and cardiac output. Norepinephrine is the ... It stimulates α1 and α2 adrenergic receptors to cause blood vessel contraction, thus increases peripheral vascular resistance ...
Generalized anxiety disorder
... α2-adrenergic receptor agonist. Guanfacine - Sympatholytic, α2-adrenergic receptor agonist. Prazosin - Sympatholytic, alpha ... 5-HT1A receptor partial agonists, such as buspirone and tandospirone. Serotonin-norepinephrine reuptake inhibitors (SNRIs), ... Hydroxyzine - Antihistamine, 5-HT2A receptor antagonist. Propranolol - Sympatholytic, beta blocker. Clonidine - Sympatholytic, ...
Rotarod performance test
Dopamine binds to alpha-1 and beta-1 adrenergic receptors. Mediated through myocardial beta-1 adrenergic receptors, dopamine ... dopamine mainly triggers dopamine receptors and β1-adrenergic receptors while at high doses it works via α-adrenergic receptors ... Alpha-1 adrenergic receptor stimulation on vascular smooth muscle, leads to vasoconstriction and results in an increase in ... Dopamine binds to beta-1, beta-2, alpha-1 and dopaminergic receptors. Pharmacy and pharmacology portal Medicine portal. ...
The alpha-1 adrenergic receptor is specifically implicated. Although it has not yet been thoroughly investigated, there is ... Administering a norepinephrine receptor agonist (a substance that initiates a cell response when it binds with a receptor) to ... these findings are based on the effects of other commonly prescribed drugs that happen to block noradrenergic receptors. ...
Table of neurotransmitter actions in the ANS
"Renal alpha-1 and alpha-2 adrenergic receptors: Biochemical and pharmacological correlations". The Journal of Pharmacology and ... Elliott, J. (1997). "Alpha-adrenoceptors in equine digital veins: Evidence for the presence of both alpha1 and alpha2-receptors ... Sagrada, A; Fargeas, M J; Bueno, L (1987). "Involvement of alpha-1 and alpha-2 adrenoceptors in the postlaparotomy intestinal ... Woodman, OL; Vatner, SF (1987). "Coronary vasoconstriction mediated by alpha 1- and alpha 2-adrenoceptors in conscious dogs". ...
"Effects of iminodibenzyl antipsychotic drugs on cerebral dopamine and alpha-adrenergic receptors". European Journal of ... Clocapramine has been reported to act as an antagonist of the D2, 5-HT2A, α1-adrenergic, and α2-adrenergic receptors, and does ... "Interaction of neuroleptics and antidepressants with rat brain alpha 2-receptors: a possible relationship between alpha 2- ... It has also been shown to have affinity for the σ receptors. Clocapramine's affinity for the 5-HT2A receptor is greater than ...
... drugs with 5-hydroxytryptamine1A and alpha 2-adrenergic receptors". Behavioral Neuroscience. 100 (5): 664-8. doi:10.1037/0735- ... It acts as a D2-like receptor agonist and also has some serotonin and adrenergic agonist effects, as well as some ... Sahin I, Tuncer M, Ilhan M (March 1990). "Dopamine receptor agonists, N,N-dipropyl-2-aminotetralin (TL-68) and 2-di-n- ... Arnerić SP, Long JP (May 1984). "Evidence that a novel dopamine receptor agonist, RDS-127 [2-di-n-propylamino-4,7- ...
... dopaminergic and alpha-adrenergic receptors. Its specific binding and activation pattern on these receptors leads to a highly, ... dopaminergic and adrenergic receptors". In Vladimír Křen,Ladislav Cvak. Ergot: the genus Claviceps. CRC Press. pp. 411-440. ... due to its agonistic action at the 5HT2A-mGlu2 receptor protomers. Clinical efficacy occurs around 200 µg, ten times lower than ... which is also an agonist at the 5HT2A-mGlu2 receptor protomer and increases the chances of a patient experiencing ...
Hypoxic pulmonary vasoconstriction
... its humoral mediators and alpha-beta adrenergic receptors". Chest. 71 (2 suppl): 249-251. doi:10.1378/chest.71.2_Supplement.249 ... such as transient receptor potential canonical 6 (TRPC6) channels, and transient receptor potential vanilloid 4 (TRPV4) ... "Classical transient receptor potential channel 6 (TRPC6) is essential for hypoxic pulmonary vasoconstriction and alveolar gas ...
Alpha α1 adrenergic receptors: This action accounts for its orthostatic hypotensive effects and perhaps some of the sedating ... Alpha α2 adrenergic receptors: Perhaps greater positive, negative, affective and cognitive symptom control. Histamine H1 ... Hecht EM, Landy DC (2012). "Alpha-2 receptor antagonist add-on therapy in the treatment of schizophrenia; a meta-analysis". ... Serotonin receptors: Its action at these receptors may be responsible for its lower extrapyramidal side effect liability (via ...
McClue SJ, Milligan G (Sep 1990). "The alpha 2B adrenergic receptor of undifferentiated neuroblastoma x glioma hybrid NG108-15 ... Osawa S, Dhanasekaran N, Woon CW, Johnson GL (Nov 1990). "G alpha i-G alpha s chimeras define the function of alpha chain ... "Characterization and distribution of alpha 2-adrenergic receptors in the human intestinal mucosa". The Journal of Clinical ... GNAI2 has been shown to interact with: EYA2, GPSM2, Interleukin 8 receptor, alpha, MDFI, RGS5, and RIC8A. GRCh38: Ensembl ...
Newer, third-generation beta blockers can cause vasodilation through blockade of alpha-adrenergic receptors. ... β2 and β3 receptors. β1-adrenergic receptors are located mainly in the heart and in the kidneys. β2-adrenergic receptors ... β3-adrenergic receptors are located in fat cells. Beta receptors are found on cells of the heart muscles, smooth muscles, ... β-adrenergic receptors and others are selective for one of the three known types of beta receptors, designated β1, ...
... is both a non-selective beta adrenergic receptor blocker (β1, β2) and an alpha adrenergic receptor blocker (α1). The ... Carvedilol reversibly binds to beta adrenergic receptors on cardiac myocytes. Inhibition of these receptors prevents a response ... Carvedilol also blocks alpha receptors, which are found on blood vessels, and relaxes the blood vessels, dilating them, which ... Beta blockers block the beta receptors on heart muscle and other cells, making them more relaxed and less responsive to stress ...
... a specific antagonist radioligand for brain alpha 2-adrenergic receptors". European Journal of Pharmacology. 76 (4): 461-4. doi ... Rauwolscine acts predominantly as a α2-adrenergic receptor antagonist. It has also been shown to function as a 5-HT1A receptor ... Perry BD, U'Prichard DC (December 1981). "[3H]rauwolscine (alpha-yohimbine): ... receptor". Naunyn-Schmiedeberg's Archives of Pharmacology. 357 (1): 17-24. doi:10.1007/PL00005133. PMID 9459568. ...
... alpha inhibitory and beta inhibitory adrenergic receptors in the guinea-pig stomach". Archives internationales de ... S. Guimarães, W. Osswald (1969). "Adrenergic receptors in the veins of the dog". European Journal of Pharmacology. 5 (2): 188- ... "Crosstalk between presynaptic angiotensin receptors, bradykinin receptors and α2-autoreceptors in sympathetic neurons: a study ... Veins and their receptors remained favourites. Guimarães has summarized the knowledge on blood vessels, their nerves and their ...
Klein U, Ramirez MT, Kobilka BK, von Zastrow M (1997). "A novel interaction between adrenergic receptors and the alpha-subunit ... Translation initiation factor eIF-2B subunit alpha is a protein that in humans is encoded by the EIF2B1 gene. EIF2B1 has been ... Flowers KM, Mellor H, Kimball SR, Jefferson LS (1996). "Structure and sequence of the gene encoding the alpha-subunit of rat ... subunit 1 alpha, 26kDa". Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li ...
alpha 2C Adrenergic Receptor抗体|Abcam中国|Anti-alpha 2C Adrenergic Receptor抗体(ab123368)
alpha 2C Adrenergic Receptor兔多克隆抗体(ab123368)可与人样本反应并经WB实验严格验证。 ... Anti-alpha 2C Adrenergic Receptor抗体. 参阅全部 alpha 2C Adrenergic Receptor 一抗. ... The alpha 2C Adrenergic Receptor controls the release of neurotransmitter from central adrenergic neurons and from sympathetic ... Anti-alpha 2C Adrenergic Receptor antibody (ab123368) at 1/100 dilution + HepG2 cell line lysates at
Clonidine For Sleep
3 It is similar to clonidine but is selective for imidazoline I 1 receptors over alpha 2-adrenergic receptors. While many times ... Its an alpha-blocker and it lessens the output of your sympathetic nervous system. But marijuana can cause giddiness that ... Clonidine is an alpha-2 adrenoreceptor agonist. Still, one of the side effects of clonidine is sedation, or sleepiness. ... Clonidine is a centrally acting alpha-agonist hypotensive agent, generally used to treat high blood pressure. Because IR ...
Alpha-2B adrenergic receptor - Wikipedia
"Expansion of the alpha 2-adrenergic receptor family: cloning and characterization of a human alpha 2-adrenergic receptor ... The alpha-2B adrenergic receptor (α2B adrenoceptor), is a G-protein coupled receptor. It is a subtype of the adrenergic ... Klein U, Ramirez MT, Kobilka BK, von Zastrow M (Aug 1997). "A novel interaction between adrenergic receptors and the alpha- ... McClue SJ, Milligan G (Sep 1990). "The alpha 2B adrenergic receptor of undifferentiated neuroblastoma x glioma hybrid NG108-15 ...
Alpha-1D adrenergic receptor - Wikipedia
The alpha-1D adrenergic receptor (α1D adrenoreceptor), also known as ADRA1D, is an alpha-1 adrenergic receptor, and also ... This gene encodes alpha-1D-adrenergic receptor. Similar to alpha-1B-adrenergic receptor gene, this gene comprises 2 exons and a ... 1994). "Cloning, expression and characterization of human alpha adrenergic receptors alpha 1a, alpha 1b and alpha 1c". Biochem ... Receptor. There are 3 alpha-1 adrenergic receptor subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 ...
Alpha-1A adrenergic receptor - Wikipedia
1994). "Cloning, expression and characterization of human alpha adrenergic receptors alpha 1a, alpha 1b and alpha 1c". Biochem ... formerly known also as the alpha-1C adrenergic receptor, is an alpha-1 adrenergic receptor, and also denotes the human gene ... a potent alpha 1-adrenergic receptor agonist, selective for the alpha 1A receptor subtype". J. Pharmacol. Exp. Ther. 274 (1): ... There are 3 alpha-1 adrenergic receptor subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G- ...
Myocardial alpha 1-adrenergic receptor stimulation. | Circulation
alpha-1 adrenergic receptor Protein Superfamily Detail
Alpha-2B adrenergic receptor - Wikipedia
The alpha-2B adrenergic receptor (α2B adrenoceptor), is a G-protein coupled receptor. It is a subtype of the adrenergic ... "Expansion of the alpha 2-adrenergic receptor family: cloning and characterization of a human alpha 2-adrenergic receptor ... ReceptorEdit. α2-adrenergic receptors include 3 highly homologous subtypes: α2A, α2B, and α2C. These receptors have a critical ... adrenergic receptor activity. • protein binding. • alpha2-adrenergic receptor activity. Cellular component. • integral ...
Familial Dysautonomia Medication: Benzodiazepines, H2 receptor antagonists, Alpha-adrenergic agonists, Corticosteroids
Alpha-adrenergic agonists. Class Summary. These agents stimulate alpha-adrenoreceptors in brain stem, activating an inhibitory ... A central alpha-adrenergic agonist that suppresses peripheral release of norepinephrine, resulting in lower blood pressure; ... H2 receptor antagonists. Class Summary. These agents are reversible competitive blockers of histamine at the H2 receptors, ... A pure peripheral alpha-adrenergic agonist, which causes peripheral vasoconstriction and raises blood pressure without ...
Insulin Downregulates Alpha-2 Adrenergic Receptors in Cultured Glial Cells | SpringerLink
Richards E.M., Raizada M.K., Sumners C. (1987) Insulin Downregulates Alpha-2 Adrenergic Receptors in Cultured Glial Cells. In: ... Using [3H]-yohimbine as a ligand for α2-adrenergic receptors, we have demonstrated that insulin is able to decrease [3H]- ... These results suggest that insulin, by modulating α2adrenergic receptor levels, is able to regulate the amount of NE present in ... Neuronal and glial cells in culture contain a2-adrenergic receptors, in preparation.Google Scholar ...
alpha 1 Adrenergic Receptor peptide (ab41797) | Abcam
Buy our alpha 1 Adrenergic Receptor peptide. Ab41797 is a blocking peptide for ab3462 and has been validated in Neut, BL. Abcam ... alpha 1 Adrenergic Receptor peptide. See all alpha 1 Adrenergic Receptor proteins and peptides. ... This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium. ... Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1D sub-subfamily. ...
Alpha-2A adrenergic receptor - DrugBank
Alpha-2B adrenergic receptor - DrugBank
Alpha-2BAR. Gene Name. ADRA2B. Organism. Human. Amino acid sequence. ,lcl,BSEQ0010396,Alpha-2B adrenergic receptor ... Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins ... lcl,BSEQ0010397,Alpha-2B adrenergic receptor (ADRA2B) ATGGACCACCAGGACCCCTACTCCGTGCAGGCCACAGCGGCCATAGCGGCGGCCATCACC ... blood coagulation / activation of MAPK activity by adrenergic receptor signaling pathway / activation of protein kinase B ...
Anti-alpha 1b Adrenergic Receptor antibody (ab15851) | Abcam
Chicken polyclonal alpha 1b Adrenergic Receptor antibody validated for WB and tested in Human. Referenced in 1 publication. ... Anti-alpha 1b Adrenergic Receptor antibody. See all alpha 1b Adrenergic Receptor primary antibodies. ... This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium ... Ten commercial antibodies for alpha-1-adrenergic receptor subtypes are nonspecific.. Naunyn Schmiedebergs Arch Pharmacol 379: ...
ADRA2A - Alpha-2A adrenergic receptor - Homo sapiens (Human) - ADRA2A gene & protein
The rank order of potency for agonists of this receptor is oxymetazoline > clonidine > epinephrine > norepinephrine > ... Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins ... alpha-1B adrenergic receptor binding Source: BHF-UCL. *alpha-2C adrenergic receptor binding Source: BHF-UCLInferred from ... alpha-1B adrenergic receptor binding Source: BHF-UCL. *alpha2-adrenergic receptor activity Source: BHF-UCL ,p>Inferred from ...
ADRA2C - Adrenergic, alpha-2C-, receptor - Homo sapiens (Human) - ADRA2C gene & protein
Adrenergic, alpha-2C-, receptorImported. ,p>Information which has been imported from another database using automatic ... tr,Q4W594,Q4W594_HUMAN Adrenergic, alpha-2C-, receptor OS=Homo sapiens OX=9606 GN=ADRA2C PE=2 SV=1 ... G-protein coupled receptorUniRule annotation. ,p>Information which has been generated by the UniProtKB automatic annotation ... Belongs to the G-protein coupled receptor 1 family.UniRule annotation. Automatic assertion according to rulesi ...
3H]rauwolscine (alpha-yohimbine): a specific antagonist radioligand for brain alpha 2-adrenergic receptors. - PubMed - NCBI
3H]rauwolscine (alpha-yohimbine): a specific antagonist radioligand for brain alpha 2-adrenergic receptors.. Perry BD, ... 3H]Rauwolscine, a specific and potent alpha 2-antagonist radioligand, was used to characterize alpha 2-receptor binding in ... These results suggest that [3H]rauwolscine specifically labels both the high and low affinity states of the alpha 2-receptor in ... rauwolscine labeled the alpha 2-receptor. Agonists inhibited [3H]rauwolscine binding in a shallow, GTP-sensitive manner. ...
Produktübersicht alpha 1 Adrenergic Receptor ELISA
alpha 1 Adrenergic Receptor ELISA Kits vergleichen und bestellen. ... alpha 1 Adrenergic Receptor ELISA Kits für viele Reaktivitäten ... alpha-1C adrenergic receptor , adrenergic alpha 1c receptor , adrenergic receptor alpha 1c subtype , adrenergic receptor, alpha ... adrenergic, alpha-1A-, receptor variant 5 , adrenergic, alpha-1A-, receptor variant 8 , alpha-1A adrenergic receptor , alpha-1A ... alpha 1C-adrenergic receptor , alpha 1a-adrenoceptor , alpha-1A-adrenergic receptor , adrenergic receptor alpha-1A ...
Selective modification of renal alpha 2-adrenergic receptors in Milan hypertensive rat strain. | Hypertension
In the cerebral cortex, no between-strain differences in alpha 1-adrenergic and alpha 2-adrenergic receptor density and ... Cerebral and renal alpha-adrenergic receptors play an important role in the control of blood pressure. We studied alpha- ... Binding of the selective alpha 1-adrenergic antagonist [3H]prazosin and the alpha 2-adrenergic antagonist [3H]rauwolscine was ... Selective modification of renal alpha 2-adrenergic receptors in Milan hypertensive rat strain.. A Parini, L Diop, P Ferrari, G ...
beta-Adrenergic regulation of alpha 2-adrenergic receptors in the central nervous system | Science
beta-Adrenergic regulation of alpha 2-adrenergic receptors in the central nervous system ... beta-Adrenergic regulation of alpha 2-adrenergic receptors in the central nervous system ... beta-Adrenergic regulation of alpha 2-adrenergic receptors in the central nervous system ... beta-Adrenergic regulation of alpha 2-adrenergic receptors in the central nervous system ...
alpha 1b Adrenergic Receptor Proteins
Order alpha 1b Adrenergic Receptor Proteins from many different species. Find the right product on antibodies-online.com. ... alpha-1B-adrenergic receptor , Adrenergic alpha 1B- receptor , adrenergic receptor, alpha 1b , alpha 1B-adrenoceptor , alpha 1B ... alpha-1B adrenoceptor , adrenergic, alpha-1B-, receptor , alpha-1B adrenergic receptor-like , alpha-1B adrenergic receptor , ... alpha 1b Adrenergic Receptor (ADRA1B) Protein Überblick Protein Überblick Alpha-1-adrenergic receptors (alpha-1-ARs) are ...
Changes in brain alpha-adrenergic receptors after alpha-methyldopa administration to spontaneously hypertensive rats. |...
The down regulation of alpha 2-adrenergic receptors and the up regulation of alpha 1-adrenergic receptors are compatible with ... larger up regulation of alpha 1-adrenergic receptors, and greater down regulation of alpha 2-adrenergic receptors than did the ... Changes in brain alpha-adrenergic receptors after alpha-methyldopa administration to spontaneously hypertensive rats.. C R ... Changes in brain alpha-adrenergic receptors after alpha-methyldopa administration to spontaneously hypertensive rats. ...
Alpha-2B adrenergic receptor | definition of alpha-2B adrenergic receptor by Medical dictionary
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Role of adrenergic alpha-2-receptors on feeding behavior in layer-type chicks.
Intracerebroventricular injection of the adrenergic alpha-2-receptor agonist, clonidine, stimulated food intake. ... The present study was designed to investigate the role of brain adrenergic alpha-2-receptors on feeding regulation of layer- ... 0/Adrenergic alpha-Agonists; 0/Adrenergic alpha-Antagonists; 0/Neuropeptide Y; 0/Neurotransmitter Agents; 0/Receptors, ... Adrenergic alpha-Agonists / pharmacology. Adrenergic alpha-Antagonists / pharmacology. Animals. Chickens / physiology*. ...
p-[125I]iodoclonidine is a partial agonist at the alpha 2-adrenergic receptor.
0/Adrenergic alpha-Agonists; 0/Iodine Radioisotopes; 0/Receptors, Adrenergic, alpha; 108294-53-7/4-iodoclonidine; 146-48-5/ ... 125I]PIC bound to the same number of high affinity sites as the alpha 2-adrenergic receptor (alpha 2-AR) full agonist [3H] ... Adrenergic alpha-Agonists / pharmacokinetics*. Blood Platelets / metabolism*. Cell Membrane / metabolism. Chromatography, Thin ... 6147954 - Adrenergic nerves and the alpha 2-adrenoceptor system regulating melanosome aggregation.... 14557414 - Prevention of ...
Molecular cloning and expression of the cDNA for the alpha 1A-adrenergic receptor. The gene for which is located on human...
The second alpha 1-adrenergic receptor cloned represents the rat homolog of the hamster alpha 1B subtype. Expression of mRNA ... We have now cloned two alpha 1-adrenergic receptors from a rat cerebral cortex cDNA library, using the hamster alpha 1B- ... Molecular cloning and expression of the cDNA for the alpha 1A-adrenergic receptor. The gene for which is located on human ... The primary structure though most closely resembles that of an alpha 1-adrenergic receptor, having approximately 73% amino acid ...
Platelet alpha 2-adrenergic receptors in hypercholesterolemia: relationship between binding studies and epinephrine-induced...
Platelet alpha 2-adrenergic receptor density is increased in hypercholesterolemia and directly correlates with plasma total and ... Conclusion: Platelet alpha 2-adrenergic receptor density is increased in hypercholesterolemia and directly correlates with ... Platelet alpha 2-adrenergic receptors in hypercholesterolemia: relationship between binding studies and epinephrine-induced ... A statistically significantly higher alpha 2-adrenergic receptor density was observed in a subgroup of 13 patients with ...
Involvement of alpha-2 adrenergic receptor subtypes in hyperglycemia. | Journal of Pharmacology and Experimental Therapeutics
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RCSB PDB - 1HOD: NMR STRUCTURE OF D130I MUTANT T3-I2, A 32 RESIDUE PEPTIDE FROM THE ALPHA 2A ADRENERGIC RECEPTOR...
NMR structure of the second intracellular loop of the alpha 2A adrenergic receptor: evidence for a novel cytoplasmic helix. ... alpha-2a adrenergic receptor pepride t3-i2 alpha-2a adrenergic receptor pepride t3-i2 alpha-2a adrenergic receptor pepride t3- ... NMR STRUCTURE OF D130I MUTANT T3-I2, A 32 RESIDUE PEPTIDE FROM THE ALPHA 2A ADRENERGIC RECEPTOR. ...
anti-alpha 2c Adrenergic Receptor antibody | GeneTex
... adrenergic, alpha-2C-, receptor) for IHC-P. Anti-alpha 2c Adrenergic Receptor pAb (GTX71833) is tested in Human samples. 100% ... adrenergic, alpha-2C-, receptor. Background. The Alpha 2c- Adrenergic Receptor controls the release of neurotransmitter from ... alpha 2c Adrenergic Receptor antibody See all alpha 2c Adrenergic Receptor products ... Storage Conditions: alpha 2c Adrenergic Receptor antibody. Storage Buffer. Phosphate buffered saline, pH 7.4 containing 0.01% ...
Human Alpha-1B Adrenergic Receptor | Cell Sciences
... alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins. ... There are 3 alpha-1 adrenergic receptor subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G- ... The majority of alpha-1 receptors are directed toward the function of epinephrine, a hormone that has to do with the fight-or- ... The receptor is available in the following formats: stable over-expression cell line, membrane preparation, or purified ...
Adrenergic, alpha-1A-, receptor | definition of adrenergic, alpha-1A-, receptor by Medical dictionary
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ClenbuterolMuscleAgonistsSubtypeAdrenoceptorADRA1APathwaysMediatesYohimbinePrazosinCatecholaminesInhibitorsAdrenoreceptorEpinephrinePolyclonalProteinPeptideSubtypes increase inhibitionRegulationLigandAdenylate cyclaseCoding sequenceEncodes the alpha-1A-adrenADRA2BNeuronsHamster alpha 1BADRA2AMetabolismSmooth muscle contractionMolecularRauwolscineBovineDopamineVasoconstrictionGenesADRA1BMediateBlockadePlatelet AggregationPhysiologicalDensityNeuroblastoma x gliomaGene on chromosomeMembranesBlockersClonidinePropranolol
- High affinity for the antagonist WB4101 and agonists phenylephrine and methoxamine suggests that cDNA RA42 encodes the alpha 1A receptor subtype. (nih.gov)
- In our study we have determined that UK-14304 (UK) and norepinephrine (NE), both alpha 2-adrenergic agonists, can augment LPS-stimulated TNF from elicited macrophages (MO). (jimmunol.org)
- These investigations support the role of alpha 2 adrenergic agonists as immunostaining compounds that may regulate cytokine production during an inflammatory response. (jimmunol.org)
- The synthesis of melatonin in mammalian pineal glands is stimulated by beta 1-adrenergic receptor agonists and is potentiated by alpha 1-adrenergic receptor agonists, whereas in the avian pineal gland alpha 2-adrenergic receptor agonists inhibit its synthesis. (aspetjournals.org)
- Incubation of these cells with tumor-promoting phorbol esters, which stimulate calcium- and phospholipid-dependent protein kinase, leads to a marked attenuation of the ability of alpha 1-receptor agonists such as norepinephrine to stimulate the turnover of inositol phospholipids. (duke.edu)
- These phorbol ester-treated cells also displayed a decrease in binding affinity of cellular alpha 1 receptors for agonists with no change in antagonist affinity. (duke.edu)
- Agonists induce the formation of a guanine nucleotide-sensitive high-affinity state of alpha 2 but not alpha 1 receptors. (meta.org)
- The alpha 2 adrenergic receptor agonists can be provided in liquid-containing formulations and/or bioerodible and/or non-bioerodible polymeric implants and microparticles. (justia.com)
- In ocular therapies, alpha agonists (e.g., agonists of alpha adrenergic receptors) are used to reduce aqueous humor production and increase aqueous humor outflow through the trabecular meshwork. (justia.com)
- Two examples of alpha agonists used for ocular therapy include apraclonidine (IOPIDINE) and brimonidine-P (ALPHAGAN-P). (justia.com)
- We observed that Na+ decreases receptor affinity for the agonists epinephrine, norepinephrine, and UK14304 and slightly increases receptor affinity for the antagonists yohimbine and idazoxan in digitonin-solubilized preparations from porcine brain cortex. (elsevier.com)
- Increases in [H+] also decrease receptor affinity for agonists and cause either a slight increase or no change in receptor affinity for antagonists. (elsevier.com)
- α2 adrenergic receptor (α2-AR) agonists have been used as antihypertensive agents, in the management of drug withdrawal, and as sedative analgesics. (jneurosci.org)
- It is a subtype of the adrenergic receptor family. (wikipedia.org)
- There is no longer a subtype α1C receptor. (wikipedia.org)
- At one time, there was a subtype known as α1C, but it was found to be identical to the previously discovered α1A receptor subtype. (wikipedia.org)
- Northern blot analysis of various rat tissues also shows the distribution expected of the alpha 1A receptor subtype with abundant expression in vas deferens followed by hippocampus, cerebral cortex, aorta, brainstem, heart and spleen. (nih.gov)
- The second alpha 1-adrenergic receptor cloned represents the rat homolog of the hamster alpha 1B subtype. (nih.gov)
- The bovine pineal alpha 2-adrenergic receptor appears to represent a pharmacological subtype distinct from the three currently proposed subtypes, i.e., alpha 2A found in a human colonic adenocarcinoma cell line (HT29 cell), alpha 2B found in rat lung, and alpha 2C found in an opossum kidney cell line (OK cell). (aspetjournals.org)
- We suggest that the bovine pineal receptor may represent a fourth pharmacological subtype, which would be designated as alpha 2D. (aspetjournals.org)
- Subtype alpha-1 adrenergic receptors consist of Alpha-1A adrenergic receptor , Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor . (bio-rad.com)
- To examine the PLC subtype mediating the alpha(1)-adrenergic receptor response, PLC-beta(1) and PLC-beta(3) were overexpressed in NCM using adenoviral infection (Ad-PLC-beta(1) NCM and Ad-PLC-beta(3) NCM, respectively) and PLC responses assessed from [(3)H]inositol phosphate (InsP) generation in the presence of 10 mm LiCl. (garvan.org.au)
- PURPOSE: To examine the localization of a novel alpha 1-adrenergic receptor subtype of alpha 1C receptor in the eye, we compared the amount of alpha 1C receptor transcripts in bovine retinal pigment epithelium (RPE) and in neural retina by employing reverse transcription of mRNA and the polymerase chain reaction (RT-PCR) assay. (arvojournals.org)
- In summary, these data represent the first side-by-side comparison of pharmacological properties between species homologs of alpha-1AR subtypes and should facilitate the development of alpha-1AR subtype selective drugs for clinical use. (duke.edu)
- The antagonist profile from the current study is most consistent with the theory that the α 2B -adrenergic receptor subtype mediates the analgesic effect of intrathecally administered tizanidine on CCI-associated neuropathic pain. (thejns.org)
- These GPCR interacting proteins (or GIPs) are largely receptor subtype and cell context specific, include both membrane and cytosolic proteins, and typically play a highly specific supporting role for GPCR function (i.e., trafficking, ligand binding, enhancing signaling, signal termination, and/or degradation) ( 2 - 4 ). (pnas.org)
- The alpha-2B adrenergic receptor (α2B adrenoceptor), is a G-protein coupled receptor. (wikipedia.org)
- Auf www.antikoerper-online.de finden Sie aktuell 44 Adrenoceptor alpha 1A (ADRA1A) ELISA Kits von 10 unterschiedlichen Herstellern. (antikoerper-online.de)
- Alpha-2 adrenoceptor stimulation induces in the mouse a hyperglycemic response which is accompanied by a concomitant inhibition of insulin secretion. (aspetjournals.org)
- To test the possibility that one of the postulated subtypes of alpha-2 adrenoceptors is preferentially implicated in this response, we compared the interaction of several drugs with known selectivity toward alpha-2A or alpha-2B adrenoceptor subtypes in our model. (aspetjournals.org)
- Both the effect on glycemic level and the inhibition of insulin release by oxymetazoline were antagonized by the alpha-2 adrenoceptor antagonist idazoxan. (aspetjournals.org)
- Alpha 2c-Adrenoceptor has been reported extensively in the brain. (genetex.com)
- Also known as Alpha-1B adrenergic receptor (Alpha-1B adrenoreceptor) (Alpha-1B adrenoceptor). (mybiosource.com)
- Chez www.anticorps-enligne.fr sont 7 Adrenoceptor alpha 1A (ADRA1A) Protéines de 4 de différents fournisseurs disponibles. (anticorps-enligne.fr)
- Recent studies have suggested that brimonidine can promote survival of injured retinal ganglion nerve cells by activation of the alpha-2-adrenoceptor in the retina and/or optic nerve. (justia.com)
- Your search returned 48 adrenoceptor alpha 2A ELISA ELISA Kit across 4 suppliers. (biocompare.com)
- Mirtazapine displays serotonin 5-HT2 and 5-HT3, receptor blocking properties, while its putative earlier onset of action is thought to be related to its 2-adrenoceptor lytic action (at 2-adrenergic autoreceptors and heteroreceptors), thereby modulating central serotonergic and noradrenergic neurotransmission. (nwu.ac.za)
- This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium. (abcam.com)
- This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. (abcam.com)
- Activation of α 1 -adrenergic receptors produces anorexia and partially mediates the efficacy of appetite suppressants like phenylpropanolamine and amphetamine in the treatment of obesity . (gutenberg.org)
- A cell membrane protein that mediates the effects of adrenergic stimulation on target organs by catecholamines. (tabers.com)
- Using [ 3 H]-yohimbine as a ligand for α 2 -adrenergic receptors, we have demonstrated that insulin is able to decrease [ 3 H]-yohimbine binding to glia in a time- and dose-dependent manner. (springer.com)
- 3H]rauwolscine (alpha-yohimbine): a specific antagonist radioligand for brain alpha 2-adrenergic receptors. (nih.gov)
- This effect was blocked by co-injection of the alpha-2-receptor antagonist, yohimbine, demonstrating that the alpha-2-receptor is related to stimulation of feeding in layer-type chicks. (biomedsearch.com)
- The concentration-effect curve for UK and NE was shifted to the right by the alpha 2-antagonist yohimbine (10(-6) M), with new EC50 of 49.7 +/- 12.2 (p less than 0.001) nM and 10.3 +/- 22 nM. (jimmunol.org)
- The presence of a MO alpha-adrenergic receptor was established by demonstrating binding of the alpha 2-adrenergic antagonist 3H-yohimbine to membranes prepared from MO. (jimmunol.org)
- Home / Test Division / Reference Database / 1990 to 1999 / 1990 / Platelet alpha-sub-2-adrenergic receptor binding to -3H-yohimbine and personality. (umn.edu)
- The epinephrine response was mediated by alpha 1 adrenergic receptors based on the greater potency of the alpha 1 adrenergic selective antagonist prazosin compared to that of the alpha 2 adrenergic selective antagonist yohimbine. (arvojournals.org)
- The results of the paw-pinch test on the affected side were compared with binding data cited in the existing literature for the three different α 2 -adrenergic receptor subtypes (α 2A , α 2B , and α 2C ) with yohimbine, prazosin, and WB4101. (thejns.org)
- Amiloride analogs accelerate the rate of [3H] yohimbine dissociation from digitonin-solubilized receptors with a relative effectiveness that parallels their ability to block Na+/H+ exchange in other systems. (elsevier.com)
- Binding of the selective alpha 1-adrenergic antagonist [3H]prazosin and the alpha 2-adrenergic antagonist [3H]rauwolscine was used for receptor studies in tissues of prehypertensive (24-day-old) and hypertensive (60-day-old) rats. (ahajournals.org)
- alpha 1-Adrenergic receptor binding (prazosin) was increased, again more in hypertensive than in normotensive rats. (ahajournals.org)
- Alpha-1 adrenergic receptors were examined in both inner and outer layers of human pregnant myometrium using radioligand binding of [3H]prazosin. (aspetjournals.org)
- 0.05) cleistanthins A and B exert a significant antihypertensive effect through alphaâ adrenergic receptor blockade similar to prazosin. (jbclinpharm.org)
- We have studied the effect of long-term (72 hour) intravenous infusions of methyldopa to awake restrained spontaneously hypertensive rats and normotensive Wistar-Kyoto control animals to look for differences in hypotensive effect, differences in concentrations of natural and alpha-methylated catecholamines, and differences in alpha 1 and alpha 2-adrenergic receptor populations. (ahajournals.org)
- The role of beta and alpha adrenergic receptors in the lipolytic effect of catecholamines on dog adipocytes. (thefreedictionary.com)
- Alpha-1-adrenergic receptors (ARs) are G protein-coupled receptors activated by catecholamines. (umn.edu)
- There are far fewer alpha-1-ARs than beta-ARs in the nonfailing heart, but their abundance is maintained or increased in the setting of heart failure, which is characterized by pronounced chronic elevation of catecholamines and beta-AR dysfunction. (umn.edu)
- Ahmed S. Ragab , Effect of alpha I adrenergic receptor inhibitors on lipid pattern in hypertensive patients, Sci. (who.int)
- Apart from the well-known angioedema/urticaria from ACE inhibitors, lichen planus / lichenoid reaction from beta adrenergic blockers and photosensitivity from thiazid diuretics, ACDR from CV drugs might be seen in a wide spectrum extending to rare but life-threatening conditions such as erythroderma, Stevens-Johnson syndrome, toxic epidermal necrolysis or drug hypersensitivity syndrome. (springer.com)
- Regulation of porcine brain alpha 2-adrenergic receptors by Na+,H+ and inhibitors of Na+/H+ exchange. (elsevier.com)
- The majority of alpha-1 receptors are directed toward the function of epinephrine, a hormone that has to do with the fight-or-flight response. (wikipedia.org)
- In addition, the lack of any guanylylimidodiphosphate effect on the l-epinephrine competition curve observed in MHS rats suggests the uncoupling of these receptors from the guanosine 5'-triphosphate binding protein. (ahajournals.org)
- Platelet alpha 2-adrenergic receptor density is increased in hypercholesterolemia and directly correlates with plasma total and levels of LDL cholesterol, providing at least a partial explanation for the enhanced platelet response to epinephrine that is observed in hypercholesterolemia. (nih.gov)
- CONCLUSIONS: Ca2+ is mobilized from intracellular stores in the sheep lens by ATP and epinephrine acting through P2U purinergic and the alpha 1A adrenergic receptors, respectively. (arvojournals.org)
- Rabbit Polyclonal to Adrenergic Receptor alpha-2A However, the pancytopenia gradually worsened, and protein anabolic steroids (metenolone, 20 mg/day time) were added to the treatment in 2009 2009. (bostonscienceandengineeringlectures.com)
- Rabbit Polyclonal to PKC alpha (phospho-Tyr657). (researchreportone.com)
- Belongs to the G-protein coupled receptor 1 family. (abcam.com)
- Association, dissociation, and saturation studies revealed one site interactions (k -1/k+1 = 1.2 nM, KD = 2.5 nM, Bmax = 160 fmol/mg protein) and competition studies indicated that [3H]rauwolscine labeled the alpha 2-receptor. (nih.gov)
- Zusätzlich bieten wir Ihnen alpha 1 Adrenergic Receptor Antikörper (92) und alpha 1 Adrenergic Receptor Proteine (7) und viele weitere Produktgruppen zu diesem Protein an. (antikoerper-online.de)
- protein kinase C modulates alpha1B-adrenergic receptor transfer to late endosomes and that Rab9 regulates this process and participates in G protein -mediated signaling turn-off. (antikoerper-online.de)
- A gene on chromosome 2p13-q13 that encodes alpha-2B-adrenergic receptor, a member of the G protein-coupled receptor superfamily, which plays a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the CNS, smooth muscle contraction and thermoregulation. (thefreedictionary.com)
- The deduced amino acid sequence of clone RA42 encodes a protein of 560 amino acids whose putative topology is similar to that of the family of G-protein-coupled receptors. (nih.gov)
- A gene on chromosome 8p21.2 that encodes alpha-1A-adrenergic receptor, a member of the G protein-coupled receptor superfamily, which activates a phosphatidylinositol-calcium second messenger system, triggering mitogenic responses and regulating growth, proliferation and signalling through the Gq/11 family of G proteins. (thefreedictionary.com)
- Receptor subtypes within families of G protein-coupled receptors that are activated by similar ligands can regulate distinct intracellular effectors. (nih.gov)
- We identified conserved motifs within intracellular domains 2 and 3 of selective subtypes of several G protein-coupled receptor families that confer coupling to the Na-H exchanger, NHE1. (nih.gov)
- These findings indicate that motifs shared by different subfamilies of G protein-coupled receptors, but not necessarily by receptor subtypes within a subfamily, can confer coupling to a common effector. (nih.gov)
- 3H] Rauwolscine bound in a saturable manner to a single class of receptors, with an equilibrium dissociation constant (KD) of 1.4 nM and a density (Bmax) of 71 fmol/mg of protein, in crude synaptic membrane preparations from bovine pineal gland. (aspetjournals.org)
- BACKGROUND: Circulating agonistic autoantibodies acting at G protein-coupled receptors have been associated with numerous sever pathologies in humans. (mdc-berlin.de)
- Alpha-1B adrenergic receptor acts through G-protein beta/gamma of pertussis toxin-sensitive Alpha activating activity polypeptide O ( G-protein alpha-o ) [ 3 ], [ 5 ]. (bio-rad.com)
- These results indicate that calcium- and phospholipid-dependent protein kinase may play an important role in regulating the function of receptors that are coupled to the inositol phospholipid cycle by phosphorylating and deactivating them. (duke.edu)
- The focus of work in this laboratory is on the elucidation of the molecular properties and regulatory mechanisms controlling the function of G protein-coupled receptors. (duke.edu)
- 100 µ g) The α -2-adrenergic receptor is a member of the G-protein coupled receptor superfamily. (allelebiotech.com)
- Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. (nih.gov)
- This protein is a member of a subfamily of G protein-coupled receptors that regulate neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. (nih.gov)
- We have cloned cDNAs encoding three human alpha-1 adrenergic receptor (AR) subtypes and characterized pharmacological properties of the expressed receptor protein. (duke.edu)
- Pharmacological characterization was performed simultaneously using six cloned alpha-1AR subtypes (human and rat alpha-1a/d, human and hamster alpha-1b, human and bovine alpha-1c) stably expressed in rat-1 fibroblasts at approximately equal receptor concentrations (1-2 pmol/mg of total protein). (duke.edu)
- The alpha-1 ( α 1 ) adrenergic receptor is a G protein-coupled receptor (GPCR) associated with the G q heterotrimeric G-protein . (gutenberg.org)
- ABBR: CCR Any of several protein receptors for chemokines that spans the cell membrane and links to intracellular G proteins. (tabers.com)
- Interestingly, these modulatory effects of Na+,H+ and 5-amino-substituted analogs of amiloride are retained in homogeneous preparations of the alpha 2-adrenergic receptor, suggesting that the allosteric-binding sites for these agents are on the receptor-binding protein itself. (elsevier.com)
- Both proteins showed typical alpha 2-adrenergic binding characteristics with specific binding activities of 13.85 nmol/mg and 14.17 nmol/mg protein. (cshl.edu)
- These values are close to the theoretical binding activity of 15.6 nmol/mg protein for 1 mol of the ligand binding 1 mol of the receptor protein. (cshl.edu)
- G protein-coupled receptors (GPCRs) are seven-transmembrane spanning proteins that are responsible for communicating information in the form of extracellular stimuli across lipid membranes into distinct intracellular signals with precise accuracy. (pnas.org)
- The alpha-1A and alpha-1B subtypes are expressed in mouse and human myocardium, whereas the alpha-1D protein is found only in coronary arteries. (umn.edu)
- In the present study we have investigated this further by examining the actions of this peptide on the regulation of α 2 -adrenergic receptors in glial cells. (springer.com)
- Synthetic peptide, corresponding to amino acids 200-299 of Human alpha 1b Adrenergic Receptor. (abcam.com)
- METHODOLOGY/PRINCIPAL FINDINGS: Using a rat model we studied the long-term action of antibodies against the alpha(1)-adrenergig receptor either induced by immunization with a receptor peptide or applied by intravenous injection. (mdc-berlin.de)
- Gentaur Molecular :Neuromi \ Alpha 2a Adrenergic Receptor, control peptide, 50 ul. (antibody-antibodies.com)
- Product Detail : P14110 Alpha 2a Adrenergic Receptor, control peptide, 50 ul. (antibody-antibodies.com)
- We have also other products like : Alpha 2a Adrenergic Receptor, control peptide, 50 ul. (antibody-antibodies.com)
- However, the peptide maps of the radioiodinated alpha 2-adrenergic receptors from rat adrenocortical carcinoma and human blood platelets reveal some distinct differences which may relate to the differences in the pharmacological specificities between rodent and non-rodent alpha 2-adrenergic receptors. (cshl.edu)
Subtypes increase inhibition2
- good selectivity over α1B, α1D and α2A subtypes further partial agonistic imidazole compounds A-61603 Tamsulosin: for treatment of benign prostatic hyperplasia Silodosin: for treatment of benign prostatic hyperplasia Risperidone WB-4101 Ziprasidone α1A-adrenergic receptor subtypes increase inhibition at dendrodendritic synapses, suggesting a synaptic mechanism for noradrenergic modulation of olfactory driven behaviors. (wikipedia.org)
- α1-adrenergic receptor subtypes increase inhibition in the olfactory system, suggesting a synaptic mechanism for noradrenergic modulation of olfactory driven behaviors. (gutenberg.org)
- Analysis of the ligand binding properties of RA42 expressed in COS-7 cells with a variety of adrenergic ligands demonstrates a unique alpha 1-adrenergic receptor pharmacology. (nih.gov)
- As assessed by NaDodSO4/polyacrylamide gel electrophoresis, the Mr 80,000 alpha 1-receptor ligand-binding subunit is a phosphopeptide containing 1.2 mol of phosphate per mol of alpha 1 receptor. (duke.edu)
- In spite of significant sequence differences between human alpha-1ARs and their other species counterparts, previously established ligand selectivity remains fairly comparable. (duke.edu)
- The present studies were designed to examine whether agents that interact with Na+/H+ antiporters also might influence alpha 2-adrenergic receptor-ligand interactions. (elsevier.com)
- These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. (wikipedia.org)
- The Alpha 2c- Adrenergic Receptor controls the release of neurotransmitter from central adrenergic neurons and from sympathetic nerves in the heart. (genetex.com)
Hamster alpha 1B3
- We have now cloned two alpha 1-adrenergic receptors from a rat cerebral cortex cDNA library, using the hamster alpha 1B-adrenergic receptor as a probe. (nih.gov)
- The primary structure though most closely resembles that of an alpha 1-adrenergic receptor, having approximately 73% amino acid identity in the putative transmembrane domains with the previously isolated hamster alpha 1B receptor. (nih.gov)
- Molecular dynamics simulations of the hamster alpha(1B)-adrenergic and the rat m3-muscarinic seven-helix bundle receptor models have been carried out. (unimore.it)
- These regional and strain differences in the metabolism of alpha-methyldopa suggest that the production of methylnorepinephrine in brain stem nuclei is most correlated with the hypotensive action of methyldopa. (ahajournals.org)
- Phorbol esters promote alpha 1-adrenergic receptor phosphorylation and receptor uncoupling from inositol phospholipid metabolism. (duke.edu)
Smooth muscle contraction1
- Pharmacological and molecular cloning studies have demonstrated heterogeneity of alpha 1-adrenergic receptors. (nih.gov)
- Bruno JF, Whittaker J, Song JF, Berelowitz M: Molecular cloning and sequencing of a cDNA encoding a human alpha 1A adrenergic receptor. (drugbank.com)
- Dr. Simpson is highly respected in the field of molecular cardiology and internationally-recognized for his contributions to our understanding of cardiac hypertrophy and alpha-1-adrenergic receptor (AR) biology. (grantome.com)
- 3H]Rauwolscine, a specific and potent alpha 2-antagonist radioligand, was used to characterize alpha 2-receptor binding in bovine cerebral cortex. (nih.gov)
- By using [3H]rauwolscine, a selective alpha 2-adrenergic receptor antagonist, we have identified for the first time alpha 2-adrenergic receptor sites in a mammalian pineal gland. (aspetjournals.org)
- The effects of phenoxybenzamine on alpha 1- and alpha 2-adrenergic receptor binding sites were examined directly using radioligand binding assays of the antagonist drugs [125I]BE 2254 and [3H]rauwolscine, respectively, in homogenates of rat cerebral cortex. (meta.org)
- Identification and characterization of alpha 2D-adrenergic receptors in bovine pineal gland. (aspetjournals.org)
- Identification of alpha 1C-adrenergic receptor mRNA in bovine retinal pigment epithelium. (arvojournals.org)
- Using the alpha 1C receptor as a model, we demonstrated the usefulness of this assay by showing the uneven distribution of the alpha 1C receptor transcripts in bovine RPE cells and neural retina. (arvojournals.org)
- In general, human alpha-1AR subtypes have similar pharmacology compared to their rat, hamster and bovine homologs, although a few minor species differences important for alpha-1AR classification are noted. (duke.edu)
- In addition, much lower inactivation (approximately 20%) by the alkylating agent chloroethylclonidine is noted in this study compared to previous reports for both human and bovine alpha-1cAR membrane preparations. (duke.edu)
- Both motifs are present in D(2)-dopamine receptors, which inhibit NHE1, and in alpha(2B)-adrenergic receptors, which couple to the inhibition of NHE1, but not in alpha(2A)-adrenergic receptors, which do not regulate NHE1. (nih.gov)
- At the end of the experiment alphaâ adrenergic receptor response of drugs like adrenaline, nor adrenaline, dopamine (doses 1 µg and 2 µg) was recorded invasively. (jbclinpharm.org)
- Any of at least six receptors that bind dopamine in the brain. (tabers.com)
- Any of a group of receptors on cell membranes that are thought to be associated with vasoconstriction, relaxation of intestinal muscle, and contraction of the nictitating membrane, iris dilator muscle, smooth muscle of the spleen, and muscular layer of the uterine wall. (thefreedictionary.com)
- In smooth muscle cells of blood vessels the principal effect of activation of these receptors is vasoconstriction . (gutenberg.org)
- In contrast to α 2 -adrenergic receptors, α 1 -adrenergic-receptors in the arterial vasculature of skeletal muscle are more resistant to inhibition, and attenuation of α1-adrenergic-receptor-mediated vasoconstriction only occurs during heavy exercise. (gutenberg.org)
- Endogenous production of NO actively dilates pulmonary vessels at rest and opposes potent alpha-mediated pulmonary vasoconstriction during exercise. (jci.org)
- It is therefore likely that brain adrenergic alpha-2-receptors mediate the orexigenic effects of neuropeptide Y and beta-endorphin in layer-type chicks. (biomedsearch.com)
- During exercise, α 1 -adrenergic receptors in active muscles are attenuated in an exercise intensity-dependent manner, allowing the β 2 -adrenergic receptors which mediate vasodilation to dominate. (gutenberg.org)
- The investigators intend to determine the effect of adrenergic blockade on 1) short-term physiology, behavior, and cognition and 2) long-term neuropsychological outcomes after severe Traumatic Brain Injury (TBI). (clinicaltrials.gov)
- The primary hypothesis is that adrenergic blockade after severe TBI will be associated with increased ventilator-free days. (clinicaltrials.gov)
- We studied the effects of inhibition of nitric oxide (NO) (endothelium-derived relaxation factor) synthase in combination with alpha and beta adrenergic receptor blockade on pulmonary vascular tone during exercise. (jci.org)
- In paired studies, we exercised sheep on a treadmill at a speed of 4 mph, and measured blood flow and pressures across the pulmonary circulation with and without inhibition of NO synthase (N omega-nitro-L-arginine 20 mg/kg intravenous [i.v.]), alpha receptor blockade (phentolamine 5 mg i.v.), beta receptor blockade (propranolol 1 mg i.v.), and combined alpha and beta receptor blockade. (jci.org)
- Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. (meta.org)
- Decades of evidence from gain and loss-of-function studies in isolated cardiac myocytes and numerous animal models demonstrate important adaptive functions for cardiac alpha-1-ARs to include physiological hypertrophy, positive inotropy, ischemic preconditioning, and protection from cell death. (umn.edu)
- The density of these receptors increased similarly with age in MHS and MNS rats. (ahajournals.org)
- 125I]PIC should prove useful in binding assays involving tissues with a low receptor density or in small tissue samples and in studies of cloned and expressed alpha 2-AR. (biomedsearch.com)
- 5) At that time, it was shown that aerobic exercisers had greater alpha-adrenergic receptor density and significantly lower beta-adrenergic receptor density than weight trainers. (freethesaurus.com)
- Treatment with phenoxybenzamine caused an irreversible, dose-dependent decrease in the density of both alpha 1- and alpha 2-adrenergic receptors. (meta.org)
- Phenoxybenzamine was approximately 250-fold more potent at decreasing alpha 1-adrenergic receptor density than it was at decreasing alpha 2-adrenergic receptor density. (meta.org)
- Furthermore, 5-HT1A receptor density is not a good marker for antidepressant action. (nwu.ac.za)
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- These agents are reversible competitive blockers of histamine at the H2 receptors, particularly those in the gastric parietal cells where they inhibit acid secretion. (medscape.com)
- An appropriate therapy for RH can be achieved by the addition of second line antihypertensive drugs: antialdosteronic diuretics, central agents, alpha blockers, direct vasodilating agents, and exogenous nitric oxide donors. (eurekaselect.com)
- It is concluded that clonidine produces (or potentiates) analgesic effects of various drugs and that the analgesic effect of nitrous oxide is attributed to the effect on the central noradrenergic system, possibly by an activation of the descending inhibitory system and/or inhibition of the primary sensory afferent neuron via alpha-2 adrenergic receptors. (nii.ac.jp)