Wakefulness-Promoting Agents

Receptors, Adrenergic, alpha-2

Receptors, Adrenergic, beta-2

Receptors, Adrenergic

Receptors, Adrenergic, alpha

Receptors, Adrenergic, beta-1

Receptors, Adrenergic, alpha-1

Receptors, Adrenergic, beta

Receptors, Adrenergic, beta-3

Adrenergic alpha-Agonists

Prazosin

Adrenergic beta-2 Receptor Antagonists

Adrenergic beta-2 Receptor Agonists

Adrenergic alpha-Antagonists

Adrenergic alpha-1 Receptor Antagonists

Adrenergic beta-Agonists

Yohimbine

Adrenergic Antagonists

Isoproterenol

Adrenergic Agonists

Propanolamines

Adrenergic beta-3 Receptor Agonists

Adrenergic alpha-2 Receptor Agonists

Norepinephrine

Clonidine

Adrenergic beta-1 Receptor Agonists

Adrenergic alpha-1 Receptor Agonists

Iodocyanopindolol

Dihydroalprenolol

Epinephrine

Adrenergic alpha-2 Receptor Antagonists

Idazoxan

Adrenergic beta-1 Receptor Antagonists

alpha 1-Antitrypsin

Adrenergic beta-Antagonists

Pindolol

Radioligand Assay

Dioxanes

Arrestins

Phenylephrine

Adenylate Cyclase

GTP-Binding Proteins

Cyclic AMP

Molecular Sequence Data

Signal Transduction

Propranolol

Cricetinae

Hypoxia-Inducible Factor 1, alpha Subunit

Butoxamine

Adrenergic beta-3 Receptor Antagonists

beta-Adrenergic Receptor Kinases

GTP-Binding Protein alpha Subunits, Gs

Clenbuterol

Cyclic AMP-Dependent Protein Kinases

Transfection

Dose-Response Relationship, Drug

Kinetics

Protein Binding

Binding, Competitive

Quinoxalines

Base Sequence

Adrenergic Agents

Cell Line

Alprenolol

Amino Acid Sequence

Oxymetazoline

Rats, Sprague-Dawley

Dopamine (medication)

Post-traumatic amnesia

Table of neurotransmitter actions in the ANS

Pelanserin

Postural orthostatic tachycardia syndrome

Vascular smooth muscle

Bronchospasm

Sympatholytic

Auditory cortex

Olanzapine

Prazosin

2C-H

Synephrine

WB-4101

Amitriptyline

4-NEMD

Postural orthostatic tachycardia syndrome

L-765,314

Rudolph Leibel

Ephedrine

Smooth muscle

Variant angina

Alpha blocker

Alpha-1 blocker

MDMA-assisted psychotherapy

Synephrine

L-765,314 - Википедија, слободна енциклопедија

Repinotan

Alpha-2B adrenergic receptor

Alpha-1D adrenergic receptor

Subtypes30

• α1-adrenergic receptor subtypes increase inhibition in the olfactory system, suggesting a synaptic mechanism for noradrenergic modulation of olfactory driven behaviors. (wikipedia.org)
• Ten commercial antibodies for alpha-1-adrenergic receptor subtypes are nonspecific. (abcam.com)
• The alpha-AR -induced mydriasis in mice is mediated mainly by the alphaA-AR, with a smaller contribution of the alphaB-AR, matching the relative abundance of these subtypes at the mRNA level. (antikoerper-online.de)
• 1 KO of the two main myocardial α1-AR subtypes, the α1A and α1B, impairs normal post-natal cardiac growth, and causes severe dilated cardiomyopathy and death after pressure overload. (pubmedcentralcanada.ca)
• Characterization of alpha-adrenergic receptor subtypes in the rat renal cortex. (aspetjournals.org)
• Guanyl nucleotides decreased the affinity of epinephrine at both receptor subtypes, but this effect was greater at the alpha 2-receptor and, according to computer analysis, occurred through different mechanisms at the two receptor subtypes. (aspetjournals.org)
• Thus, separate alpha 1- and alpha 2-adrenergic receptors can be detected in the rat renal cortex and binding to both receptor subtypes can be regulated by guanyl nucleotides and Na+ X Na+ may directly interact with alpha 2- but not alpha 1-adrenergic receptors in the renal cortex. (aspetjournals.org)
• Our findings with renal cortical membranes indicate that regulation of agonist binding at alpha-adrenergic receptor subtypes by guanyl nucleotides and Na+ is not limited to alpha 2-adrenergic receptors, as previously reported with other tissues. (aspetjournals.org)
• We have cloned cDNAs encoding three human alpha-1 adrenergic receptor (AR) subtypes and characterized pharmacological properties of the expressed receptor protein. (duke.edu)
• Pharmacological characterization was performed simultaneously using six cloned alpha-1AR subtypes (human and rat alpha-1a/d, human and hamster alpha-1b, human and bovine alpha-1c) stably expressed in rat-1 fibroblasts at approximately equal receptor concentrations (1-2 pmol/mg of total protein). (duke.edu)
• In general, human alpha-1AR subtypes have similar pharmacology compared to their rat, hamster and bovine homologs, although a few minor species differences important for alpha-1AR classification are noted. (duke.edu)
• All six alpha-1AR subtypes couple to phosphoinositide hydrolysis in a pertussis toxin-insensitive manner, including the cloned human alpha-1a/dAR which had not been expressed previously. (duke.edu)
• In summary, these data represent the first side-by-side comparison of pharmacological properties between species homologs of alpha-1AR subtypes and should facilitate the development of alpha-1AR subtype selective drugs for clinical use. (duke.edu)
• It consists of three highly homologous subtypes, including α 1A - , α 1B - , and α 1D -adrenergic . (gutenberg.org)
• The research plan follows naturally from the applicant's recent novel work identifying the tissue distribution of the 3 alpha-1-AR subtypes in the human heart. (grantome.com)
• Abundant data from animal studies, including knockout mouse models created by the mentor, show that the alpha-1 A and alpha-IB subtypes play beneficial roles in the heart and protect against HF. (grantome.com)
• Surprisingly, the function of the human cardiac alpha-1-AR subtypes is unknown, and alpha-1-ARs have never been studied in human heart cells. (grantome.com)
• III) Identify the functional alpha-1-AR subtypes in human coronary smooth muscle and endothelial cells. (grantome.com)
• α2-adrenergic receptors include 3 highly homologous subtypes: α2A, α2B, and α2C. (wikipedia.org)
• There are 3 alpha-1 adrenergic receptor subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. (wikipedia.org)
• This study provides definitive evidence for the existence of three alpha 1-adrenergic receptor subtypes. (nih.gov)
• Three distinct alpha-1 adrenergic receptor subtypes (alpha-1a, alpha-1b and alpha-1d) have been identified through molecular cloning. (elsevier.com)
• The results of the present study indicate that alpha-1 adrenergic receptor subtypes are discretely distributed among rat tissues, suggesting independent functions. (elsevier.com)
• There are three families of adrenergic receptors, alpha 1 , alpha 2 and beta, and each family contains three distinct subtypes. (thefreedictionary.com)
• α 2 -adrenergic receptors include 3 highly homologous subtypes: α 2A , α 2B , and α 2C . (wikipedia.org)
• Left ventricular hypertrophy (LVH) is associated with decreased responsiveness of renal α1-adrenoreceptors subtypes to adrenergic agonists. (bireme.br)
• This study investigated the impact of nitric oxide (NO) and its potential interaction with the responsiveness of renal α1-adrenoreceptors subtypes to adrenergic stimulation in rats with left ventricular hypertrophy (LVH). (bireme.br)
• Clonidine and other α-2 agonists used clinically (tizanidine, brimonidine and dexmedetomidine) activate to varying degrees three structurally distinct subtypes of the α-2 receptor: α-2A, α-2B, and α-2C. (asahq.org)
• Further research to define the role of various alpha receptor subtypes is needed to identify strategies for separating the analgesic and sedative effects of α-2 agonists. (asahq.org)
• Adrenergic alpha2 receptors are divided into three subtypes in humans: alpha2A, alpha2B and alpha2C. (genecards.org)

Agonists16

• Other effects on smooth muscle are contraction in: Ureter Uterus (when pregnant): this is minor compared to the relaxing effects of the β2 receptor, agonists of which - notably albuterol/salbutamol - were formerly[citation needed] used to inhibit premature labor. (wikipedia.org)
• Incubation of these cells with tumor-promoting phorbol esters, which stimulate calcium- and phospholipid-dependent protein kinase, leads to a marked attenuation of the ability of alpha 1-receptor agonists such as norepinephrine to stimulate the turnover of inositol phospholipids. (duke.edu)
• These phorbol ester-treated cells also displayed a decrease in binding affinity of cellular alpha 1 receptors for agonists with no change in antagonist affinity. (duke.edu)
• High affinity for the antagonist WB4101 and agonists phenylephrine and methoxamine suggests that cDNA RA42 encodes the alpha 1A receptor subtype. (nih.gov)
• Shumay E, Gavi S, Wang HY and Malbon CC (2004) Trafficking of beta2‐adrenergic receptors: insulin and beta‐agonists regulate internalisation by distinct cytoskeletal pathways. (els.net)
• The responsiveness of renal α1A, α1B and α1D-adrenoceptors in the low dose and high dose phases of 5-MeU, CEC and BMY7378 to adrenergic agonists was increased along with cGMP in the kidney of LVH-NO group. (bireme.br)
• These findings suggest that exogenous NO precursor up-regulated the renal eNOS/NO/cGMP pathway in LVH rats and resulted in augmented α1A, α1B and α1D adrenoreceptors responsiveness to the adrenergic agonists. (bireme.br)
• Although complete selectivity between receptor agonism is rarely achieved, phenylephrine is an α 1 agonist, while clonidine and methyldopa are α 2 partial agonists [1] . (wikidoc.org)
• Alpha-adrenergic agonists are used in the treatment of glaucoma by decreasing the production of aqueous fluid by the ciliary bodies of the eye. (wikidoc.org)
• α-2-ADRENOCEPTORS are known to mediate analgesia, and α-2-adrenoceptor agonists (such as clonidine) have proven effective in the treatment of pain, such as intractable cancer pain, 1,2 postsurgical pain, 3,4 and sympathetically maintained pain. (asahq.org)
• The α-2A receptor was necessary for the analgesic activity of brimonidine, clonidine, and tizanidine, but a surprising difference identified in the activity of the α-2 agonists in α-2C knockout mice led to investigation of the roles of α-1 and α-2 receptor activation in pain modulation. (asahq.org)
• Here we show that while the carazolol pocket captured in the β 2 AR crystal structure accommodates (-)-isoproterenol and other agonists without steric clashes, a finite movement of the flexible extracellular part of TM-V helix (TM-Ve) obtained by receptor optimization in the presence of docked ligand can further improve the calculated binding affinities for agonist compounds. (pubmedcentralcanada.ca)
• Tilting of TM-Ve towards the receptor axis provides a more complete description of polar receptor/ligand interactions for full and partial agonists, by enabling optimal engagement of agonists with two experimentally identified anchor sites, formed by Asp113/Asn312 and Ser203/Ser204/Ser207 side chains. (pubmedcentralcanada.ca)
• Further, receptor models incorporating a flexible TM-V backbone allow reliable prediction of binding affinities for a set of diverse ligands, suggesting potential utility of this approach to design of effective and subtype-specific agonists for adrenergic receptors. (pubmedcentralcanada.ca)
• The responses mediated through the receptors that are activated by the partial agonists are resistant to myosin light chain kinase inhibitors, while the response through the activation of the other receptors are suppressed by the inhibitors. (nii.ac.jp)
• To further elucidate the significance of NE- and Glu-evoked astrocytic [Ca2+]i signaling to neuron-astrocyte communication in the mature CNS, [Ca2+]i of astrocyte networks within hippocampal slices (P21-42) was measured during bath application of NE and Glu receptor agonists. (jneurosci.org)

Agonist27

• In the mouse bleomycin model of right ventricular failure, the alpha1A -adrenergic receptor subtype agonist A61603 prevents right ventricular failure. (antikoerper-online.de)
• alpha 2 Agonist binding (p-amino-clonidine) declined in both hypothalamus and brain stem, and the fall was greater in hypertensive than in normotensive rats. (ahajournals.org)
• The down regulation of alpha 2-adrenergic receptors and the up regulation of alpha 1-adrenergic receptors are compatible with increased alpha 2-adrenergic agonist presynaptic inhibition of catecholamine release with resultant postsynaptic alpha 1-adrenergic receptor supersensitivity. (ahajournals.org)
• Is the attenuation of beta-adrenergic agonist efficacy during labor caused by elevated prostaglandin E levels? (biomedsearch.com)
• OBJECTIVE: Our purpose was to investigate whether attenuation of beta-adrenergic agonist efficacy during labor is due to elevated prostaglandin E levels. (biomedsearch.com)
• STUDY DESIGN: beta-Receptor function (response to beta-agonist or forskolin) was tested in mononuclear leukocytes collected from women at term before or during labor. (biomedsearch.com)
• An optical section of the fluorescent receptors is obtained by epifluorescence confocal microscopy from insulin‐treated (a), untreated (b) and β‐adrenergic agonist‐treated (c) cells. (els.net)
• Hadcock JR and Malbon CC (1988) Down‐regulation of beta‐adrenergic receptors: agonist‐induced reduction in receptor mRNA levels. (els.net)
• Kallal L, Gagnon AW, Penn RB and Benovic JL (1998) Visualization of agonist‐induced sequestration and down‐regulation of a green fluorescent protein‐tagged beta2‐adrenergic receptor. (els.net)
• 2004) Characterization of agonist stimulation of cAMP‐dependent protein kinase and G protein‐coupled receptor kinase phosphorylation of the beta2‐adrenergic receptor using phosphoserine‐specific antibodies. (els.net)
• An adrenergic alpha-agonist is a drug which selectively stimulates alpha adrenergic receptors . (wikidoc.org)
• Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. (uniprot.org)
• However, the extent of beta-arrestin involvement appears to vary significantly depending on the receptor, agonist and cell type. (uniprot.org)
• The 2.4 Å crystal structure of the β 2 -adrenergic receptor (β 2 AR) in complex with the high-affinity inverse agonist (-)-carazolol provides a detailed structural framework for the analysis of ligand recognition by adrenergic receptors. (pubmedcentralcanada.ca)
• Xylometazoline is a direct acting sympathomimetic adrenergic alpha-agonist used to induce systemic vasoconstriction, thereby decreasing nasal congestion. (hmdb.ca)
• Biocompatible intraocular implants include an alpha-2 adrenergic receptor agonist and a polymer associated with the alpha-2 adrenergic receptor agonist to facilitate release of the alpha-2 adrenergic receptor agonist into an eye for an extended period of time. (freepatentsonline.com)
• The alpha-2 adrenergic receptor agonist may be associated with a biodegradable polymer matrix, such as a matrix of a two biodegradable polymers. (freepatentsonline.com)
• 1. A biodegradable intraocular implant for improving vision, the implant comprising an alpha-2 adrenergic receptor agonist and a biodegradable polymer, the implant capable of releasing the alpha-2 adrenergic receptor agonist from the polymer, upon intravitreal placement of the implant, in an amount effective to improve the vision of the eye in which the implant is placed. (freepatentsonline.com)
• 2. The implant of claim 1, wherein the alpha-2 adrenergic receptor agonist is selected from the group consisting of quinoxalines, (2-imidozolin-2-ylamino) quinoxalines, 5-bromo-6-(2-imidozolin-2-ylamino) quinoxalines, derivatives thereof and mixtures thereof. (freepatentsonline.com)
• 4. The implant of claim 1, wherein the alpha-2 adrenergic receptor agonist is brimonidine tartrate. (freepatentsonline.com)
• 5. The implant of claim 1, wherein the alpha-2 adrenergic receptor agonist is dispersed within the biodegradable polymer. (freepatentsonline.com)
• 7. The implant of claim 1, wherein the polymer releases drug at a rate effective to sustain release of an amount of the alpha-2 adrenergic receptor agonist from the implant for more than one month from the time the implant is placed in the vitreous of the eye. (freepatentsonline.com)
• 8. The implant of claim 1, wherein the polymer releases drug at a rate effective to sustain release of an amount of the alpha-2 adrenergic receptor agonist from the implant for more than forty days from the time the implant is placed in the vitreous of the eye. (freepatentsonline.com)
• In virgin rats, the PKC activator phorbol 12,13-dibutyrate (PDBu, 10 − 6 M) and the α-adrenergic agonist phenylephrine (Phe, 10 − 5 M) caused significant increases in active stress and PKC activity that were inhibited by the PKC inhibitors staurosporine and calphostin C. Western blot analysis in aortic strips of virgin rats showed significant amount of the α-PKC isoform. (physiology.org)
• The alpha 1- agonist phenylephrine (PE) (10-100 microM) evoked complex [Ca2+]i signals (22 of 26 slices, 90 of 90 cells in responding slices) composed of both a prolonged component (5.1 +/- 1.8 min), synchronized in neighboring cells, and multiple, mainly asynchronous [Ca2+]i spikes (25.0 +/- 11.6 sec). (jneurosci.org)
• The alpha 2-agonist clonidine (10- 100 microM) did not increase [Ca2+]i (n = 4 slices). (jneurosci.org)
• The metabotropic agonist t-ACPD (30 or 50 microM) did not increase astrocytic [Ca2+]i in hippocampal slices (0 of 5), while kainate (200 microM or 1 mM) induced brief (1-2 min) [Ca2+]i increases only rarely (2 of 8 applications in 6 slices). (jneurosci.org)

Subtype9

• At one time, there was a subtype known as α1C, but it was found to be identical to the previously discovered α1A receptor subtype. (wikipedia.org)
• However, the alpha receptor mediating renal arteriolar vasoconstriction appeared to be of the alpha-1 subtype as there was a close correlation between the in vitro results and the binding data determined with [3H]prazosin (r = 0.93). (aspetjournals.org)
• Expression of alpha 1 adrenergic receptor subtype mRNAs in the rat cardiovascular system with aging. (harvard.edu)
• Subtype alpha-1 adrenergic receptors consist of Alpha-1A adrenergic receptor , Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor . (bio-rad.com)
• We have used the subtype-selective radioligands [3H]prazosin (an alpha 1-adrenergic antagonist) and [3H]yohimbine (an alpha 2-adrenergic antagonist) to examine alpha-adrenergic receptors in rat renal cortical membranes. (aspetjournals.org)
• To examine the PLC subtype mediating the alpha(1)-adrenergic receptor response, PLC-beta(1) and PLC-beta(3) were overexpressed in NCM using adenoviral infection (Ad-PLC-beta(1) NCM and Ad-PLC-beta(3) NCM, respectively) and PLC responses assessed from [(3)H]inositol phosphate (InsP) generation in the presence of 10 mm LiCl. (garvan.org.au)
• It is a subtype of the adrenergic receptor family. (wikipedia.org)
• Northern blot analysis of various rat tissues also shows the distribution expected of the alpha 1A receptor subtype with abundant expression in vas deferens followed by hippocampus, cerebral cortex, aorta, brainstem, heart and spleen. (nih.gov)
• The second alpha 1-adrenergic receptor cloned represents the rat homolog of the hamster alpha 1B subtype. (nih.gov)

Antagonists5

• Alpha-1 adrenergic antagonists increased the probability of calculus expulsion by 27% (NNT=4). (scielo.br)
• Hoffman BB (2001) Catecholamines, sympathetic drugs, and adrenergic receptor antagonists. (els.net)
• This structure, followed by other co-crystals of β 2 AR ( Hanson and others 2008b ) and β 1 AR ( Warne and others 2008 ) with the antagonists (-)-timolol (PDB code 3D4S) and (-)-cyanopindolol (PDB code 2VT4) respectively, represents a leap forward in the understanding of the inactive state of adrenergic GPCRs. (pubmedcentralcanada.ca)
• Alpha antagonists are used to treat what? (studystack.com)
• non-selective adrenergic antagonists are used to treat what? (studystack.com)

Antagonist9

• 3H]Dihydroergocryptine, a nonselective alpha adrenergic antagonist, the alpha-1 selective antagonist, [3H]prazosin and the alpha-2 selective antagonist, [3H]yohimbine, were used to study binding sites in rat renal membranes. (aspetjournals.org)
• In addition, in both the functional and [3H]prazosin binding studies, unlabeled prazosin ws 5 to 40-fold more potent than the nonselective antagonist, phentolamine, and 400- to 1500-fold more potent than the alpha-2 antagonist, yohimbine. (aspetjournals.org)
• The effects of phenoxybenzamine on alpha 1- and alpha 2-adrenergic receptor binding sites were examined directly using radioligand binding assays of the antagonist drugs [125I]BE 2254 and [3H]rauwolscine, respectively, in homogenates of rat cerebral cortex. (meta.org)
• This review analyzed the outcome of alpha adrenergic antagonist in children with ureteral calculi. (scielo.br)
• Studies on RX 781094: a selective, potent and specific antagonist of alpha 2-adrenoceptors. (semanticscholar.org)
• RAPAFLO (TM) is an effective, uniquely selective alpha-1 adrenergic receptor antagonist. (bio-medicine.org)
• Binding of the selective alpha 1-adrenergic antagonist [3H]prazosin and the alpha 2-adrenergic antagonist [3H]rauwolscine was used for receptor studies in tissues of prehypertensive (24-day-old) and hypertensive (60-day-old) rats. (ahajournals.org)
• Compared with their age-matched normotensive controls, MHS rats showed 1) a lower affinity for the antagonist (p less than 0.05) in the prehypertensive period, 2) absence of the normal age-related increase in receptor density, and 3) a lower density of [3H]rauwolscine binding sites (p less than 0.001) in the hypertensive period. (ahajournals.org)
• PE responses were completely blocked by the alpha 1-antagonist prazosin (200 nM, n = 4 slices), but not by the alpha 2- antagonist yohimbine (n = 3 slices). (jneurosci.org)

Beta-adrenergic9

• RESULTS: Mononuclear leukocytes from women in active labor exhibited a significant attenuation of beta-adrenergic receptor function as a result of reduced adenylyl cyclase activity. (biomedsearch.com)
• This effect could be induced in mononuclear leukocytes from nonlaboring women by preincubation with prostaglandin E but not oxytocin or prostaglandin F. CONCLUSIONS: Prostaglandin E induces heterologous desensitization of the beta-adrenergic receptor system in mononuclear leukocytes, comparable to that seen during labor. (biomedsearch.com)
• Beta-adrenergic receptor interactions. (biomedsearch.com)
• alpha-adrenergic, which act in response to sympathomimetic stimuli, and beta-adrenergic, which block sympathomimetic activity. (thefreedictionary.com)
• 1996) The beta‐adrenergic receptor is a substrate for the insulin receptor tyrosine kinase. (els.net)
• 1987) Ligand binding to the beta‐adrenergic receptor involves its rhodopsin‐like core. (els.net)
• alpha- and beta-adrenergic pathways differentially regulate cell type-specific apoptosis in rat cardiac myocytes. (semanticscholar.org)
• However, it is unknown if alpha- and beta-adrenergic pathways coordinately or differentially regulate apoptosis and if this apoptotic pathway uses common or cell type-specific apoptotic signals. (semanticscholar.org)
• Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. (uniprot.org)

Pharmacology4

• Analysis of the ligand binding properties of RA42 expressed in COS-7 cells with a variety of adrenergic ligands demonstrates a unique alpha 1-adrenergic receptor pharmacology. (nih.gov)
• Journal of Pharmacology and Experimental Therapeutics , 244 (1), 226-230. (elsevier.com)
• Minneman, KP, Mumford, GK & Abel, PW 1988, ' High efficiency coupling of alpha-1 adrenergic receptors to inositol phospholipid metabolism revealed by denervation of rat vas deferens ', Journal of Pharmacology and Experimental Therapeutics , vol. 244, no. 1, pp. 226-230. (elsevier.com)
• We investigated the α-adrenergic pharmacology of analgesia using models of tactile hypersensitivity induced with chemical stimuli that sensitize pain pathways at spinal or peripheral sites. (asahq.org)

Vasoconstriction7

• In smooth muscle cells of blood vessels the principal effect of activation of these receptors is vasoconstriction. (wikipedia.org)
• In contrast to α2-adrenergic receptors, α1-adrenergic-receptors in the arterial vasculature of skeletal muscle are more resistant to inhibition, and attenuation of α1-adrenergic-receptor-mediated vasoconstriction only occurs during heavy exercise. (wikipedia.org)
• Resting muscle will not have its α1-adrenergic receptors blocked, and hence the overall effect will be α1-adrenergic-mediated vasoconstriction. (wikipedia.org)
• To establish a correlation between binding and a biological function, the ability of alpha adrenergic agents to stimulate or inhibit vasoconstriction was quantified in vitro using an isolated perfused kidney preparation. (aspetjournals.org)
• Despite the preponderance of alpha-2 receptors, the alpha receptor mediating renal vasoconstriction appears to be of the alpha-1 type. (aspetjournals.org)
• Alpha receptor effects Vasoconstriction, reduced GI tract motility. (thefreedictionary.com)
• Which adrenergic receptor is responsible for vasoconstriction of the arterioles in the skin and viscera, and intestinal relaxation? (studystack.com)

Regulation7

• Autonomic Receptor-mediated Regulation of Production and Release of Nitric Oxide in Normal and Malignant Human Urothelial Cells. (abcam.com)
• Differential regulation of alpha 1- and alpha 2-adrenergic receptors by guanyl nucleotides and Na. (aspetjournals.org)
• Operating via heterotrimeric G proteins, adrenergic receptors constitute one of the most intensely studied classes of membrane proteins, whose expression and function are subject to regulation at many different levels, including transcriptional, posttranscriptional and posttranslational. (els.net)
• Kohout TA and Lefkowitz RJ (2003) Regulation of G protein‐coupled receptor kinases and arrestins during receptor desensitization. (els.net)
• Krupnick JG and Benovic JL (1998) The role of receptor kinases and receptors in G‐protein‐coupled receptor regulation. (els.net)
• Shenoy SK, McDonal PH, Kohout TA and Lefkowitz RJ (2001) Regulation of receptor fate by ubiquitination of activated beta2‐adrenergic receptor and beta‐arrestin. (els.net)
• Inhibitory presynaptic receptor regulation in ANS and ENS. (studystack.com)

Stimulation9

• DDT1 MF-2 cells, which are derived from hamster vas deferens smooth muscle, contain alpha 1-adrenergic receptors (54,800 +/- 2700 sites per cell) that are coupled to stimulation of inositol phospholipid metabolism. (duke.edu)
• PLC-delta(1) overexpression selectively reduced NE-induced [(3)H]InsP responses, without affecting the ATP stimulation. (garvan.org.au)
• alpha(1)-Adrenergic receptor activation caused phosphorylation of PLC-beta(1) but not PLC-beta(3), whereas stimulation by ATP induced phosphorylation of PLC-beta(3) but not PLC-beta(1. (garvan.org.au)
• These data indicate (i) that the regions of the alpha 1AR that determine coupling to phosphatidylinositol metabolism are similar to those previously shown to be involved in coupling of beta 2AR to adenylate cyclase stimulation and (ii) that point mutations of a G-protein-coupled receptor can cause remarkable increases in sensitivity of biological response. (duke.edu)
• Receptor activation leads to stimulation of PLC. (duke.edu)
• a site in a sympathetic effector cell that reacts to adrenergic stimulation. (thefreedictionary.com)
• In general, stimulation of alpha receptors is excitatory of the function of the host organ or tissue, and stimulation of the beta receptors is inhibitory. (thefreedictionary.com)
• Compounds that bind to and block the stimulation of ADENOSINE A1 RECEPTORS. (nih.gov)
• These results support a primary role of NE release and alpha 1-adrenoceptor stimulation in neuron-astrocyte communication in the mature CNS. (jneurosci.org)

Adrenoceptor4

• Auf www.antikoerper-online.de finden Sie aktuell 44 Adrenoceptor alpha 1A (ADRA1A) ELISA Kits von 10 unterschiedlichen Herstellern. (antikoerper-online.de)
• Chez www.anticorps-enligne.fr sont 7 Adrenoceptor alpha 1A (ADRA1A) Protéines de 4 de différents fournisseurs disponibles. (anticorps-enligne.fr)
• The alpha-2B adrenergic receptor (α2B adrenoceptor), is a G-protein coupled receptor. (wikipedia.org)
• ADRA2B (Adrenoceptor Alpha 2B) is a Protein Coding gene. (genecards.org)

Mediate4

• α1-receptors primarily mediate smooth muscle contraction, but have important functions elsewhere as well. (wikipedia.org)
• During exercise, α1-adrenergic receptors in active muscles are attenuated in an exercise intensity-dependent manner, allowing the β2-adrenergic receptors which mediate vasodilation to dominate. (wikipedia.org)
• alpha(1)-adrenergic receptors mediate LH-releasing hormone secretion through phospholipases C and A(2) in immortalized hypothalamic neurons. (duke.edu)
• Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. (drugbank.ca)

Alpha2-adrenergic recept1

• GO annotations related to this gene include G-protein coupled receptor activity and alpha2-adrenergic receptor activity . (genecards.org)

Adenylate Cyclase2

• Although binding of epinephrine to both alpha 1- and alpha 2-receptors could be modulated by guanyl nucleotides, we were unable to detect inhibition by epinephrine of basal or hormone-stimulated adenylate cyclase activity. (aspetjournals.org)
• Beta receptors are divided into beta1, beta2, beta3, which are linked to Gs, and adenylate cyclase, increasing cAMP, which in turn drives cAMP-dependent protein kinase that mediates intracellular events. (thefreedictionary.com)

Selective5

• this effect was more Na+-selective at alpha 2- than at alpha 1-receptors. (aspetjournals.org)
• The reduced NE response was associated with a selective loss of PLC-beta(1) expression in Ad-PLC-delta(1) NCM. (garvan.org.au)
• RAPAFLO (TM) is a new, uniquely selective alpha blocker for the treatment of the signs and symptoms of BPH, launched earlier this month by Watson Pharmaceuticals, a leader in generic and specialty branded pharmaceuticals. (bio-medicine.org)
• Selective modification of renal alpha 2-adrenergic receptors in Milan hypertensive rat strain. (ahajournals.org)
• Trazodone hydrochloride is a selective serotonin reuptake inhibitor indicated for the treatment of major depressive disorder (MDD) ( 1 ). (nih.gov)

Phosphorylation4

• Phorbol esters promote alpha 1-adrenergic receptor phosphorylation and receptor uncoupling from inositol phospholipid metabolism. (duke.edu)
• The effect of phorbol esters on norepinephrine-stimulated inositol phospholipid turnover and alpha 1-receptor phosphorylation showed the same rapid time course with a t1/2 less than 2 min. (duke.edu)
• Counterregulation by growth factor receptor tyrosine kinases and homologous desensitization by GRKs share many similarities in receptor phosphorylation, use of accessory proteins and sequestration of the receptors. (els.net)
• Here, we report the effects of constitutive activation of α 1 -adrenergic signaling on connexin phosphorylation and cardiac conduction. (ahajournals.org)

Murine2

• H-Ras then activates v-raf-1 murine leukemia viral oncogene homolog 1 ( c-Raf-1 ) / Mitogen-activated protein kinase kinases 1 and 2 ( MEK1(MAP2K1) and MEK2(MAP2K2) )/ Mitogen activated protein kinase 1 ( ERK2(MAPK1) ) [ 1 ], [ 10 ]. (bio-rad.com)
• The role of adrenergic activation on murine luteal cell viability and progesterone production. (semanticscholar.org)

Vasodilation2

• It inhibits postsynaptic alpha-adrenergic receptors, resulting in vasodilation of veins and arterioles and a decrease in total peripheral resistance and blood pressure. (medscape.com)
• Which adrenergic receptor causes vasodilation of skeletal muscle and liver, intestinal relaxation, bronchodilation, and increased metabolic rate? (studystack.com)

Arterioles1

• Xylometazoline is a direct acting sympathomimetic drug, which acts on alpha-adrenergic receptors in the arterioles of the nasal mucosa. (hmdb.ca)

Norepinephrine12

• To avoid confusion, naming was continued with the letter D. Catecholamines like norepinephrine (noradrenaline) and epinephrine (adrenaline) signal through the α1-adrenergic receptor in the central and peripheral nervous systems. (wikipedia.org)
• The neurotransmitter norepinephrine has higher affinity for the α1 receptor than does the hormone epinephrine/adrenaline. (wikipedia.org)
• In particular, norepinephrine decreases glutamatergic excitatory postsynaptic potentials by the activation of α1-adrenergic receptors. (wikipedia.org)
• Norepinephrine also stimulates serotonin release by binding α1-adrenergic receptors located on serotonergic neurons in the raphe. (wikipedia.org)
• The functional status of these alpha-1 adrenergic receptors was also assessed by measuring the norepinephrine-induced accumulation of inositol phosphates in myometrial tissue. (aspetjournals.org)
• However, norepinephrine-induced increases in inositol 1,4,5-triphosphate were only observed in the outer layer. (aspetjournals.org)
• At higher doses, olanzapine increased the concentrations of the norepinephrine metabolite, MHPG-SO4, probably by blocking alpha 1-adrenergic receptors. (nih.gov)
• Activation of phospholipase C (PLC) in neonatal rat cardiomyocytes (NCM) generates primarily inositol 1,4,5-trisphosphate (Ins(1,4,5)P(3)) in response to rises in intracellular Ca(2+), or inositol 1,4-bisphosphate (Ins(1,4)P(2)) in response to norepinephrine (NE) (Matkovich, S. J. and Woodcock, E. A. (2000) J. Biol. (garvan.org.au)
• Catecholamines like norepinephrine (noradrenaline) and epinephrine (adrenaline) signal through the α 1 -adrenergic receptor in the central and peripheral nervous systems . (gutenberg.org)
• In denervated tissues, the potency of norepinephrine in stimulating [ 3 H]IP accumulation was decreased about 40-fold after receptor inactivation with 1 μM phenoxybenzamine. (elsevier.com)
• These results suggest that there is a substantial alpha-1 adrenergic receptor reserve for stimulating [ 3 H]IP accumulation in rat vas deferens which is normally obscured by rapid inactivation of norepinephrine. (elsevier.com)
• This receptor binds epinephrine and norepinephrine with approximately equal affinity. (uniprot.org)

Neurons4

• With the immortalized hypothalamic LHRH neurons, we have found that alpha(1)-adrenergic agents directly stimulate the secretion of LHRH in a dose-dependent manner. (duke.edu)
• PLC beta 1 and PLC beta 3 are expressed in GT1 neurons, and these PLCs are probably responsible for the release of diacylglycerol and IP as well as the increase in intracellular calcium. (duke.edu)
• These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. (wikipedia.org)
• This protein is a member of a subfamily of G protein-coupled receptors that regulate neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. (genecards.org)

Cerebral cortex3

• We have now cloned two alpha 1-adrenergic receptors from a rat cerebral cortex cDNA library, using the hamster alpha 1B-adrenergic receptor as a probe. (nih.gov)
• Expression of mRNA for this receptor is strongly detected in liver followed by heart, cerebral cortex, brain stem, kidney, lung, and spleen. (nih.gov)
• In the cerebral cortex, no between-strain differences in alpha 1-adrenergic and alpha 2-adrenergic receptor density and affinity were observed in prehypertensive and hypertensive periods. (ahajournals.org)

Myocardium2

• The myocardium contains adrenergic receptors (ARs) of two main classes, β and α1. (pubmedcentralcanada.ca)
• 15,16 Increased α 1 -adrenergic signaling in the myocardium of heart failure patients might contribute to defective cardiac conduction and to arrhythmias. (ahajournals.org)

Protein-coupled receptor3

• The alpha-1 (α1) adrenergic receptor is a G protein-coupled receptor (GPCR) associated with the Gq heterotrimeric G-protein. (wikipedia.org)
• α1-Adrenergic receptors are members of the G protein-coupled receptor superfamily. (wikipedia.org)
• Marchese A, Chen C, Kim YM and Benovic JL (2003) The ins and outs of G‐protein‐coupled receptor trafficking. (els.net)

Characterization of human1

• Cloning and pharmacological characterization of human alpha-1 adrenergic receptors: sequence corrections and direct comparison with other species homologues. (duke.edu)

Gene7

• A mutation of rs2322333, located in the intronic and 3' UTR (zeige UTS2R ELISA Kits ) part of the gene ADRA1A in chromosome 8, has a probability of being deleterious the abolition of ELAV-like protein 1 (ELAVL1 (zeige ELAVL1 ELISA Kits )) binding site rs2695260. (antikoerper-online.de)
• The human gene encoding this receptor has the symbol ADRA2B. (wikipedia.org)
• The alpha-1D adrenergic receptor (α 1D adrenoreceptor), also known as ADRA1D , is an alpha-1 adrenergic receptor , and also denotes the human gene encoding it. (wikipedia.org)
• This gene encodes alpha-1D-adrenergic receptor. (wikipedia.org)
• Similar to alpha-1B-adrenergic receptor gene, this gene comprises 2 exons and a single intron that interrupts the coding region. (wikipedia.org)
• α 1 -Adrenergic signaling targets the transcription factor RTEF-1 (transcription enhancer factor-1-related factor) to upregulate gene expression in cultured cardiac myocytes. (ahajournals.org)
• 17,18 To better understand how RTEF-1 regulates cardiac gene expression and affects cardiac function in vivo, we made transgenic mice that overexpress RTEF-1 in the heart. (ahajournals.org)

MRNA3

• Expression of alpha-1 adrenergic receptor mRNA has been detected in several tissues, but previous studies with Northern blot analysis or RNase protection assays have provided only semiquantitative information. (elsevier.com)
• In the present study, we quantified alpha-1a, alpha-1b and alpha-1d adrenergic receptor mRNA in 19 adult rat tissues through the use of reverse transcription (RT) and a competitive polymerase chain reaction (PCR). (elsevier.com)
• Competitive RT-PCR is an accurate and sensitive method for the measurement of alpha-1 adrenergic receptor mRNA in small tissue samples. (elsevier.com)

Encodes1

• The deduced amino acid sequence of clone RA42 encodes a protein of 560 amino acids whose putative topology is similar to that of the family of G-protein-coupled receptors. (nih.gov)

Intracellular3

• Internalized arrestin-receptor complexes traffic to intracellular endosomes, where they remain uncoupled from G-proteins. (uniprot.org)
• Beta-arrestins function as multivalent adapter proteins that can switch the GPCR from a G-protein signaling mode that transmits short-lived signals from the plasma membrane via small molecule second messengers and ion channels to a beta-arrestin signaling mode that transmits a distinct set of signals that are initiated as the receptor internalizes and transits the intracellular compartment. (uniprot.org)
• alpha 1-mediated [Ca2+]i transients were observed after removal of extracellular [Ca2+]o (n = 8 of 9 slices), indicating PE-induced Ca2+ release from intracellular stores. (jneurosci.org)

Benign Prostatic H2

• In addition to this newly issued patent Synaptic has 16 applications pending on its alpha adrenergic receptor and benign prostatic hyperplasia technology. (thefreedictionary.com)
• The alpha adrenergic receptor system, which responds to the neurotransmitter adrenaline, is an important signaling mechanism in the body and is believed to be involved in such diverse therapeutic indications as cardiovascular disease, benign prostatic hyperplasia (BPH), pain and glaucoma. (thefreedictionary.com)

GPCR1

• While detailed knowledge of ligand-receptor interactions would be instrumental in design of new and improved clinical candidates, the insight into spatial structure of GPCR has been limited to ab initio models ( Goddard and Abrol 2007 ) or models based on rhodopsin crystal structure ( Palczewski and others 2000 ). (pubmedcentralcanada.ca)

Catecholamines4

• We have studied the effect of long-term (72 hour) intravenous infusions of methyldopa to awake restrained spontaneously hypertensive rats and normotensive Wistar-Kyoto control animals to look for differences in hypotensive effect, differences in concentrations of natural and alpha-methylated catecholamines, and differences in alpha 1 and alpha 2-adrenergic receptor populations. (ahajournals.org)
• 1) Alpha receptors, which evoke an excitatory response of smooth muscle cells to catecholamines. (thefreedictionary.com)
• 2) Beta receptors, which dampen the response to catecholamines. (thefreedictionary.com)
• In patients with heart failure, chronically elevated catecholamines upset the balance between β- and α 1 -adrenergic receptors. (ahajournals.org)

Nonselective alpha adrenergic2

• Phenoxybenzamine is a nonselective alpha-adrenergic receptor blocker that antagonizes both alpha-1 and alpha-2 receptors. (medscape.com)
• The advantage of prazosin over nonselective alpha-adrenergic blockers includes a lower incidence of adverse effects. (medscape.com)

Blockers5

• However, literature about the use of alpha-1 adrenergic blockers in pediatric population with distal ureterolithiasis is still scarce. (scielo.br)
• This review has the objective to evaluate the use of alpha-1 adrenergic blockers as medical expulsive treatment in children with distal ureterolithiasis. (scielo.br)
• In the adult patient, there are various conservative treatments to treat calculi smaller than 12mm, such as the use of calcium blockers, non-steroidal anti-inflammatory agents, or alpha-1 adrenergic blockers, which is the better approach ( 9 ). (scielo.br)
• The agents used include alpha-adrenergic blockers, 5-alpha-reductase inhibitors, phosphodiesterase-5 enzyme inhibitors, and various combinations. (medscape.com)
• What is the suffix for alpha blockers? (studystack.com)

Cardiac9

• α1-AR gain-of-function in cardiac transgenic models generally supports the KO results, although phenotypes vary greatly with receptor level, promoter, and absence or presence of an activating mutation. (pubmedcentralcanada.ca)
• Dr. Simpson is highly respected in the field of molecular cardiology and internationally-recognized for his contributions to our understanding of cardiac hypertrophy and alpha-1-adrenergic receptor (AR) biology. (grantome.com)
• Collectively these Aims will establish a broader understanding of human cardiac alpha-1-AR biology and the mechanisms of HF. (grantome.com)
• Cardiac alpha1-adrenergic receptors: novel aspects of expression, signaling mechanisms, physiologic function, and clinical importance. (semanticscholar.org)
• In animal models of heart failure, cardiac α 1 -adrenergic signaling is constitutively activated. (ahajournals.org)
• Methods and Results- Transgenic mice were generated with cardiac-specific overexpression of the transcription factor RTEF-1 (transcription enhancer factor-1-related factor), which mediates α 1 -adrenergic signaling in cardiac myocytes. (ahajournals.org)
• Intercellular dye transfer between RTEF-1 transgenic cardiac myocytes confirmed impaired conduction at the cellular level. (ahajournals.org)
• Confocal microscopy revealed increased levels of dephosphorylated connexin43 at the cardiac gap junctions in RTEF-1 mice, suggesting that defective conduction is a result of impaired gap-junction conductance rather than assembly. (ahajournals.org)
• 1 Connexin40, 43, and 45 encode the cardiac gap-junction proteins. (ahajournals.org)

Muscarinic receptors2

• The ability of the atypical antipsychotic drug candidate olanzapine to antagonize dopamine, serotonin, alpha-adrenergic and muscarinic receptors in vivo was assessed by various neurochemical measurements in rat brain. (nih.gov)
• The findings provide evidence that olanzapine antagonized dopamine, serotonin, alpha-adrenergic and muscarinic receptors in vivo, consistent with its high affinity for these receptor sites in vitro. (nih.gov)

Antibodies5

• Antibodies directed predominantly against the alpha(1)-adrenergig receptor were detected in patients suffering from widespread diseases such as hypertension and type 2 diabetes. (mdc-berlin.de)
• We postulate that antibodies to the alpha(1)-adrenergig receptor are relevant pathomolecules in diseases of the central nervous system associated with vascular impairments. (mdc-berlin.de)
• METHODOLOGY/PRINCIPAL FINDINGS: Using a rat model we studied the long-term action of antibodies against the alpha(1)-adrenergig receptor either induced by immunization with a receptor peptide or applied by intravenous injection. (mdc-berlin.de)
• CONCLUSION/SIGNIFICANCE: We present evidence that antibodies to the α(1)-adrenergig receptor cause cerebrovascular impairments in the rat. (mdc-berlin.de)
• 81 Adrenergic, alpha-1B-, Receptor (ADRA1B) Antibodies from 13 manufacturers are available on www.antibodies-online.com. (antibodies-online.com)

Phenoxybenzamine2

• Treatment with phenoxybenzamine caused an irreversible, dose-dependent decrease in the density of both alpha 1- and alpha 2-adrenergic receptors. (meta.org)
• Phenoxybenzamine was approximately 250-fold more potent at decreasing alpha 1-adrenergic receptor density than it was at decreasing alpha 2-adrenergic receptor density. (meta.org)

Variety of adrenergic1

• Moreover, the order of potencies of a variety of adrenergic agents, determined by competitive inhibition studies, suggested that the binding of each radioligand was to sites with alpha adrenergic specificity. (aspetjournals.org)

Renal6

• Blood vessels with α1-adrenergic receptors are present in the skin, the sphincters of gastrointestinal system, kidney (renal artery) and brain. (wikipedia.org)
• Renal alpha-1 and alpha-2 adrenergic receptors: biochemical and pharmacological correlations. (aspetjournals.org)
• These studies suggest that rat renal plasma membranes contain binding sites with both alpha-1 and alpha-2 adrenergic receptor specificity, in a ratio of approximately 1:3. (aspetjournals.org)
• Cerebral and renal alpha-adrenergic receptors play an important role in the control of blood pressure. (ahajournals.org)
• We studied alpha-adrenergic receptors in the cerebral and renal cortex of Milan hypertensive strain (MHS) and normotensive strain (MNS) rats, a genetic model of spontaneous hypertension linked to a kidney abnormality. (ahajournals.org)
• In the renal cortex, the differences between MHS and MNS rats concerned alpha 2-adrenergic receptors only. (ahajournals.org)

Beta22

• Tao J, Wang HY and Malbon CC (2003) Protein kinase A regulates AKAP250 (gravin) scaffold binding to the beta2‐adrenergic receptor. (els.net)
• Adrenergic alpha2 receptors (alpha2-adrenoceptors) are members of the adrenergic receptor group of G-protein-coupled receptors that also includes alpha1A, alpha1B, alpha1D, beta1, beta2 and beta3. (genecards.org)

Dopamine1

• Inactivation of dopamine D1 and D2 receptors by EEDQ was antagonized by olanzapine. (nih.gov)

Phospholipase2

• G-proteins also activate Phospholipase C beta 1 ( PLC-beta1 ) [ 6 ]. (bio-rad.com)
• Regions of the hamster alpha 1-adrenergic receptor (alpha 1 AR) that are important in GTP-binding protein (G protein)-mediated activation of phospholipase C were determined by studying the biological functions of mutant receptors constructed by recombinant DNA techniques. (duke.edu)

Responses2

• Adrenergic receptors are cell‐surface receptors for two major catecholamine hormones and neurotransmitters that regulate key physiological responses, including cardiovascular and pulmonary functions. (els.net)
• Adrenergic responses were mediated by alpha 1- receptors localized to astrocytes because PE and NE increased [Ca2+]i of acutely isolated hippocampal astrocytes. (jneurosci.org)

Cholinergic1

• Cholinergic receptors are receptive to what? (studystack.com)

Hamster1

• The primary structure though most closely resembles that of an alpha 1-adrenergic receptor, having approximately 73% amino acid identity in the putative transmembrane domains with the previously isolated hamster alpha 1B receptor. (nih.gov)

Plasma membrane2

• Class A receptors, like ADRB2, OPRM1, ENDRA, D1AR and ADRA1B dissociate from beta-arrestin at or near the plasma membrane and undergo rapid recycling. (uniprot.org)
• Receptor resensitization then requires that receptor-bound arrestin is removed so that the receptor can be dephosphorylated and returned to the plasma membrane. (uniprot.org)

Neurotransmitter1

• [1] The neurotransmitter noradrenaline has higher affinity for the α1 receptor than does adrenaline (which is a hormone). (gutenberg.org)

Inositol phosphate1

• The effect of surgical denervation on alpha-1 adrenergic receptor-stimulated inositol phosphate (IP) formation was examined in rat vas deferens. (elsevier.com)

Trafficking2

• Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. (meta.org)
• Discover the latest research on adrenergic receptor trafficking here. (meta.org)

Antibody2

• In ELISA experiment, the ELISA microwell plate was first coated with anti-FLAG M2 antibody, which recognizes the FLAG-tagged alpha(1A)-AR, then the cell lysis, anti-HA rabbit polyclonal antibody and HRP conjugated anti- rabbit antibody were added in turn. (bvsalud.org)
• In co-immunoprecipitation experiments, HEK293 cells expressing alpha(1A)-AR or/and segment of BMP-1 were lysed and incubated with anti-FLAG M2 antibody, then the immunoprecipitation pellet was immunoblotted with either the HRP conjugated anti-FLAG antibody or the anti-HA antibody, which recognizes the HA-tagged segment of BMP-1. (bvsalud.org)

Stably expressed1

• alpha1A -adrenergic receptors are stably expressed and stimulate cell migration and TGF-beta1 (zeige TGFB1 ELISA Kits ), IGF-1 (zeige IGF1 ELISA Kits ), hyaluronan and PIP (zeige PIP ELISA Kits ) production in human skin fibroblasts. (antikoerper-online.de)

Molecular5

• The focus of work in this laboratory is on the elucidation of the molecular properties and regulatory mechanisms controlling the function of G protein-coupled receptors. (duke.edu)
• Molecular cloning and expression of the cDNA for the alpha 1A-adrenergic receptor. (nih.gov)
• Pharmacological and molecular cloning studies have demonstrated heterogeneity of alpha 1-adrenergic receptors. (nih.gov)
• This procedure used internal cRNA standards as competitive templates that contained sequences complementary to the primers for alpha-1a, alpha-1b and alpha-1d adrenergic receptors and that differed in molecular size from the native sequences. (elsevier.com)
• 1989) Molecular characterization of the human beta 3‐adrenergic receptor. (els.net)

Rats6

• Pre-diabetes augments neuropeptide Y1- and a1-receptor control of basal hindlimb vascular tone in young ZDF rats. (abcam.com)
• Changes in brain alpha-adrenergic receptors after alpha-methyldopa administration to spontaneously hypertensive rats. (ahajournals.org)
• alpha 1-Adrenergic receptor binding (prazosin) was increased, again more in hypertensive than in normotensive rats. (ahajournals.org)
• The density of these receptors increased similarly with age in MHS and MNS rats. (ahajournals.org)
• In addition, the lack of any guanylylimidodiphosphate effect on the l-epinephrine competition curve observed in MHS rats suggests the uncoupling of these receptors from the guanosine 5'-triphosphate binding protein. (ahajournals.org)
• This is supported by reports that the expression and specific actions of NO synthase are elevated during late gestation in rats ( 1 , 5 ) and that the plasma level, metabolic production, and urinary excretion of cGMP, a second messenger of NO and a cellular mediator of vascular smooth muscle relaxation, are increased during pregnancy ( 4 ). (physiology.org)

Stimulate1

• Counterregulation by growth factor receptor tyrosine kinases and homologous desensitization by GRKs both stimulate the sequestration of β2‐AR. (els.net)

Ligand4

• As assessed by NaDodSO4/polyacrylamide gel electrophoresis, the Mr 80,000 alpha 1-receptor ligand-binding subunit is a phosphopeptide containing 1.2 mol of phosphate per mol of alpha 1 receptor. (duke.edu)
• In spite of significant sequence differences between human alpha-1ARs and their other species counterparts, previously established ligand selectivity remains fairly comparable. (duke.edu)
• Ligand binding and RNA studies demonstrate that the GT1 cells contain both alpha(1A)- and alpha(1B)-ARs. (duke.edu)
• Involved in the degradation of cAMP by recruiting cAMP phosphodiesterases to ligand-activated receptors. (uniprot.org)

Vascular1

• These results demonstrate a critical role for the alpha(1B (zeige CACNA1B Proteine ))AR in baroreceptor-mediated adrenergic signaling at the vascular neuroeffector junction. (antikoerper-online.de)

Signaling3

• Conclusion- Constitutive activation of α 1 -adrenergic signaling through the RTEF-1 transcription factor results in chronic elevation of PP1β expression and connexin dephosphorylation. (ahajournals.org)
• Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling (By similarity). (uniprot.org)
• protein kinase C modulates alpha1B-adrenergic receptor transfer to late endosomes and that Rab9 regulates this process and participates in G protein -mediated signaling turn-off. (antikoerper-online.de)

Produkte1

• Insgesamt sind aktuell 149 alpha 1 Adrenergic Receptor Produkte verfügbar. (antikoerper-online.de)